Involving Teachers in Data-Driven Decision Making: Using Computer Data Systems to Support Teacher Inquiry and Reflection

ERIC Educational Resources Information Center

Wayman, Jeffrey C.

2005-01-01

Accountability mandates such as No Child Left Behind (NCLB) have drawn attention to the practical use of student data for school improvement. Nevertheless, schools may struggle with these mandates because student data are often stored in forms that are difficult to access, manipulate, and interpret. Such access barriers additionally preclude the…

The Influence of Visual and Spatial Reasoning in Interpreting Simulated 3D Worlds.

ERIC Educational Resources Information Center

Lowrie, Tom

2002-01-01

Explores ways in which 6-year-old children make sense of screen-based images on the computer. Uses both static and relatively dynamic software programs in the investigation. Suggests that young children should be exposed to activities that establish explicit links between 2D and 3D objects away from the computer before attempting difficult links…

Phase transitions and dynamics of bulk and interfacial water.

PubMed

Franzese, G; Hernando-Martínez, A; Kumar, P; Mazza, M G; Stokely, K; Strekalova, E G; de los Santos, F; Stanley, H E

2010-07-21

New experiments on water at the surface of proteins at very low temperature display intriguing dynamic behaviors. The extreme conditions of these experiments make it difficult to explore the wide range of thermodynamic state points needed to offer a suitable interpretation. Detailed simulations suffer from the same problem, where equilibration times at low temperature become extremely long. We show how Monte Carlo simulations and mean field calculations using a tractable model of water help interpret the experimental results. Here we summarize the results for bulk water and investigate the thermodynamic and dynamic properties of supercooled water at an interface.

Design and interpretation of cell trajectory assays

PubMed Central

Bowden, Lucie G.; Simpson, Matthew J.; Baker, Ruth E.

2013-01-01

Cell trajectory data are often reported in the experimental cell biology literature to distinguish between different types of cell migration. Unfortunately, there is no accepted protocol for designing or interpreting such experiments and this makes it difficult to quantitatively compare different published datasets and to understand how changes in experimental design influence our ability to interpret different experiments. Here, we use an individual-based mathematical model to simulate the key features of a cell trajectory experiment. This shows that our ability to correctly interpret trajectory data is extremely sensitive to the geometry and timing of the experiment, the degree of motility bias and the number of experimental replicates. We show that cell trajectory experiments produce data that are most reliable when the experiment is performed in a quasi-one-dimensional geometry with a large number of identically prepared experiments conducted over a relatively short time-interval rather than a few trajectories recorded over particularly long time-intervals. PMID:23985736

Beaked Whale Group Deep Dive Behavior from Passive Acoustic Monitoring

DTIC Science & Technology

2015-09-30

1 DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. Beaked Whale Group Deep Dive Behavior from Passive...N000141512649 LONG-TERM GOALS While a significant body of knowledge regarding individual beaked whale behavior at depth has been established in the...last decade, little is known about how beaked whales interact as a group at depth. This lack of information makes it difficult to interpret the

Biasing, acquisition, and interpretation of a dense Langmuir probe array in NSTX.

PubMed

Jaworski, M A; Kallman, J; Kaita, R; Kugel, H; LeBlanc, B; Marsala, R; Ruzic, D N

2010-10-01

A dense array of 99 Langmuir probes has been installed in the lower divertor region of the National Spherical Torus Experiment (NSTX). This array is instrumented with a system of electronics that allows flexibility in the choice of probes to bias as well as the type of measurement (including standard swept, single probe, triple probe, and operation as passive floating potential and scrape-off-layer SOL current monitors). The use of flush-mounted probes requires careful interpretation. The time dependent nature of the SOL makes swept-probe traces difficult to interpret. To overcome these challenges, the single- and triple-Langmuir probe signals are used in complementary fashion to determine the temperature and density at the probe location. A comparison to midplane measurements is made.

Analysis and interpretation of electrical resistivity tomography data of alluvial aquifer of Tamanrasset Southern Algeria

NASA Astrophysics Data System (ADS)

Zeddouri, Aziez; Elkheir, Abderrahmane Ben; Hadj-Said, Samia; Taupin, Jean-Denis; Leduc, Christian; Patris, Nicholas

2018-05-01

A groundwater exploration work in the Tamanrasset region in southern Algeria was started in August 2016 to assess the water reserves in the hydrogeological system related to the Oued Tamanrasset underflow water table which overcomes a volcanic basement. Five (05) electrical resistivity tomography (ERT) surveys were conducted in Tamanrasset area by using ABEM Terrameter LS system. the low electrical contrast between wet alluvium and water saturated alterites makes difficult the electrical response interpretation. to overcome the difficulties of interpretation of ERT profiles, field investigations, laboratory tests and software simulations, were carried out in order to clearly identify the structure of the hydrogeological system. The experimental investigation of the electrical characteristics of the alluvium as a function of water saturation was carried by the use of two devices (Wenner α and Schlumberger). Samples true resistivity values varies between 50 Ω.m for a 100% saturated sample and 1250 Ω.m for a 25% saturation sample. The interpretation of the measurements by the RES2DINV software made it possible to give 2D images of the subsoil up to a depth of 50 m. the electrical contrast between the bedrock and the overlying formations made it possible to identify it, however, it was difficult to distinguish alterites from alluvium. A methodology combining piezometric survey, geo-electrical measurements and field observations improves the interpretation of electrical tomography profiles and the application of the ERT method for accurate characterization of water resources in the Tamanrasset region.

New ideas for teaching electrocardiogram interpretation and improving classroom teaching content.

PubMed

Zeng, Rui; Yue, Rong-Zheng; Tan, Chun-Yu; Wang, Qin; Kuang, Pu; Tian, Pan-Wen; Zuo, Chuan

2015-01-01

Interpreting an electrocardiogram (ECG) is not only one of the most important parts of diagnostics but also one of the most difficult areas to teach. Owing to the abstract nature of the basic theoretical knowledge of the ECG, its scattered characteristics, and tedious and difficult-to-remember subject matter, teaching how to interpret ECGs is as difficult for teachers to teach as it is for students to learn. In order to enable medical students to master basic knowledge of ECG interpretation skills in a limited teaching time, we modified the content used for traditional ECG teaching and now propose a new ECG teaching method called the "graphics-sequence memory method." A prospective randomized controlled study was designed to measure the actual effectiveness of ECG learning by students. Two hundred students were randomly placed under a traditional teaching group and an innovative teaching group, with 100 participants in each group. The teachers in the traditional teaching group utilized the traditional teaching outline, whereas the teachers in the innovative teaching group received training in line with the proposed teaching method and syllabus. All the students took an examination in the final semester by analyzing 20 ECGs from real clinical cases and submitted their ECG reports. The average ECG reading time was 32 minutes for the traditional teaching group and 18 minutes for the innovative teaching group. The average ECG accuracy results were 43% for the traditional teaching group and 77% for the innovative teaching group. Learning to accurately interpret ECGs is an important skill in the cardiac discipline, but the ECG's mechanisms are intricate and the content is scattered. Textbooks tend to make the students feel confused owing to the restrictions of the length and the format of the syllabi, apart from many other limitations. The graphics-sequence memory method was found to be a useful method for ECG teaching.

How accurate are leukocyte indices and C-reactive protein for diagnosis of neonatal sepsis?

PubMed Central

da Silva, Orlando; Ohlsson, Arne

1998-01-01

Early diagnosis of neonatal sepsis is often difficult to make. Treatment on the basis of clinical suspicion and risk factors may result in overtreatment. A previous review of the usefulness of C-reactive protein and leukocyte indices concluded that these test results should be interpreted with caution. The present paper reviews and, when appropriate, revises, in light of new information, the conclusions reached in the previous systematic review of the topic. PMID:20401235

Crystal Graph Convolutional Neural Networks for an Accurate and Interpretable Prediction of Material Properties

NASA Astrophysics Data System (ADS)

Xie, Tian; Grossman, Jeffrey C.

2018-04-01

The use of machine learning methods for accelerating the design of crystalline materials usually requires manually constructed feature vectors or complex transformation of atom coordinates to input the crystal structure, which either constrains the model to certain crystal types or makes it difficult to provide chemical insights. Here, we develop a crystal graph convolutional neural networks framework to directly learn material properties from the connection of atoms in the crystal, providing a universal and interpretable representation of crystalline materials. Our method provides a highly accurate prediction of density functional theory calculated properties for eight different properties of crystals with various structure types and compositions after being trained with 1 04 data points. Further, our framework is interpretable because one can extract the contributions from local chemical environments to global properties. Using an example of perovskites, we show how this information can be utilized to discover empirical rules for materials design.

Expertise and decision-making in American football

PubMed Central

Woods, Adam J.; Kranjec, Alexander; Lehet, Matt; Chatterjee, Anjan

2015-01-01

In American football, pass interference calls can be difficult to make, especially when the timing of contact between players is ambiguous. American football history contains many examples of controversial pass interference decisions, often with fans, players, and officials interpreting the same event differently. The current study sought to evaluate the influence of experience with concepts important for officiating decisions in American football on the probability (i.e., response criteria) of pass interference calls. We further investigated the extent to which such experience modulates perceptual biases that might influence the interpretation of such events. We hypothesized that observers with less experience with the American football concepts important for pass interference would make progressively more pass interference calls than more experienced observers, even when given an explicit description of the necessary criteria for a pass interference call. In a go/no-go experiment using photographs from American football games, three groups of participants with different levels of experience with American football (Football Naïve, Football Player, and Football Official) made pass interference calls for pictures depicting left-moving and right-moving events. More experience was associated with progressively and significantly fewer pass interference calls [F(2,48) = 10.4, p < 0.001], with Football Naïve participants making the most pass interference calls, and Football Officials the least. In addition, our data replicated a prior finding of spatial biases for interpreting left-moving images more harshly than identical right-moving images, but only in Football Players. These data suggest that experience with the concepts important for making a decision may influence the rate of decision-making, and may also play a role in susceptibility to spatial biases. PMID:26217294

Expertise and decision-making in American football.

PubMed

Woods, Adam J; Kranjec, Alexander; Lehet, Matt; Chatterjee, Anjan

2015-01-01

In American football, pass interference calls can be difficult to make, especially when the timing of contact between players is ambiguous. American football history contains many examples of controversial pass interference decisions, often with fans, players, and officials interpreting the same event differently. The current study sought to evaluate the influence of experience with concepts important for officiating decisions in American football on the probability (i.e., response criteria) of pass interference calls. We further investigated the extent to which such experience modulates perceptual biases that might influence the interpretation of such events. We hypothesized that observers with less experience with the American football concepts important for pass interference would make progressively more pass interference calls than more experienced observers, even when given an explicit description of the necessary criteria for a pass interference call. In a go/no-go experiment using photographs from American football games, three groups of participants with different levels of experience with American football (Football Naïve, Football Player, and Football Official) made pass interference calls for pictures depicting left-moving and right-moving events. More experience was associated with progressively and significantly fewer pass interference calls [F (2,48) = 10.4, p < 0.001], with Football Naïve participants making the most pass interference calls, and Football Officials the least. In addition, our data replicated a prior finding of spatial biases for interpreting left-moving images more harshly than identical right-moving images, but only in Football Players. These data suggest that experience with the concepts important for making a decision may influence the rate of decision-making, and may also play a role in susceptibility to spatial biases.

Ethics in perioperative practice--patient advocacy.

PubMed

Schroeter, Kathryn

2002-05-01

Though often difficult, ethical decision making is necessary when caring for surgical patients. Perioperative nurses have to recognize ethical dilemmas and be prepared to take action based on the ethical code outlined in the American Nurses Association's (ANA's) Code of Ethics for Nurses with Interpretive Statements. In this second of a nine-part series that will help perioperative nurses relate the ANA code to their own area of practice, the author looks at the third provision statement, which addresses nurses' position as patient advocates.

Assessing the significance of Palaeolithic engraved cortexes. A case study from the Mousterian site of Kiik-Koba, Crimea

PubMed Central

d’Errico, Francesco; Stepanchuk, Vadim

2018-01-01

Twenty-Seven Lower and Middle Paleolithic sites from Europe and the Middle East are reported in the literature to have yielded incised stones. At eleven of these sites incisions are present on flint cortexes. Even when it is possible to demonstrate that the engravings are ancient and human made, it is often difficult to distinguish incisions resulting from functional activities such as butchery or use as a cutting board, from those produced deliberately, and even more difficult to identify the scope of the latter. In this paper we present results of the analysis of an engraved cortical flint flake found at Kiik-Koba, a key Mousterian site from Crimea, and create an interpretative framework to guide the interpretation of incised cortexes. The frame of inference that we propose allows for a reasoned evaluation of the actions playing a role in the marking process and aims at narrowing down the interpretation of the evidence. The object comes from layer IV, the same layer in which a Neanderthal child burial was unearthed, which contains a para-Micoquian industry of Kiik-Koba type dated to between c.35 and 37 cal kyr BP. The microscopic analysis and 3D reconstruction of the grooves on the cortex of this small flint flake, demonstrate that the incisions represent a deliberate engraving made by a skilled craftsman, probably with two different points. The lines are nearly perfectly framed into the cortex, testifying of well controlled motions. This is especially the case considering the small size of the object, which makes this a difficult task. The production of the engraving required excellent neuromotor and volitional control, which implies focused attention. Evaluation of the Kiik-Koba evidence in the light of the proposed interpretative framework supports the view that the engraving was made with a representational intent. PMID:29718916

Assessing the significance of Palaeolithic engraved cortexes. A case study from the Mousterian site of Kiik-Koba, Crimea.

PubMed

Majkić, Ana; d'Errico, Francesco; Stepanchuk, Vadim

2018-01-01

Twenty-Seven Lower and Middle Paleolithic sites from Europe and the Middle East are reported in the literature to have yielded incised stones. At eleven of these sites incisions are present on flint cortexes. Even when it is possible to demonstrate that the engravings are ancient and human made, it is often difficult to distinguish incisions resulting from functional activities such as butchery or use as a cutting board, from those produced deliberately, and even more difficult to identify the scope of the latter. In this paper we present results of the analysis of an engraved cortical flint flake found at Kiik-Koba, a key Mousterian site from Crimea, and create an interpretative framework to guide the interpretation of incised cortexes. The frame of inference that we propose allows for a reasoned evaluation of the actions playing a role in the marking process and aims at narrowing down the interpretation of the evidence. The object comes from layer IV, the same layer in which a Neanderthal child burial was unearthed, which contains a para-Micoquian industry of Kiik-Koba type dated to between c.35 and 37 cal kyr BP. The microscopic analysis and 3D reconstruction of the grooves on the cortex of this small flint flake, demonstrate that the incisions represent a deliberate engraving made by a skilled craftsman, probably with two different points. The lines are nearly perfectly framed into the cortex, testifying of well controlled motions. This is especially the case considering the small size of the object, which makes this a difficult task. The production of the engraving required excellent neuromotor and volitional control, which implies focused attention. Evaluation of the Kiik-Koba evidence in the light of the proposed interpretative framework supports the view that the engraving was made with a representational intent.

Monitoring and Identifying in Real time Critical Patients Events.

PubMed

Chavez Mora, Emma

2014-01-01

Nowadays pervasive health care monitoring environments, as well as business activity monitoring environments, gather information from a variety of data sources. However it includes new challenges because of the use of body and wireless sensors, nontraditional operational and transactional sources. This makes the health data more difficult to monitor. Decision making in this environment is typically complex and unstructured as clinical work is essentially interpretative, multitasking, collaborative, distributed and reactive. Thus, the health care arena requires real time data management in areas such as patient monitoring, detection of adverse events and adaptive responses to operational failures. This research presents a new architecture that enables real time patient data management through the use of intelligent data sources.

Heart Rate Variability and Cardiac Vagal Tone in Psychophysiological Research – Recommendations for Experiment Planning, Data Analysis, and Data Reporting

PubMed Central

Laborde, Sylvain; Mosley, Emma; Thayer, Julian F.

2017-01-01

Psychophysiological research integrating heart rate variability (HRV) has increased during the last two decades, particularly given the fact that HRV is able to index cardiac vagal tone. Cardiac vagal tone, which represents the contribution of the parasympathetic nervous system to cardiac regulation, is acknowledged to be linked with many phenomena relevant for psychophysiological research, including self-regulation at the cognitive, emotional, social, and health levels. The ease of HRV collection and measurement coupled with the fact it is relatively affordable, non-invasive and pain free makes it widely accessible to many researchers. This ease of access should not obscure the difficulty of interpretation of HRV findings that can be easily misconstrued, however, this can be controlled to some extent through correct methodological processes. Standards of measurement were developed two decades ago by a Task Force within HRV research, and recent reviews updated several aspects of the Task Force paper. However, many methodological aspects related to HRV in psychophysiological research have to be considered if one aims to be able to draw sound conclusions, which makes it difficult to interpret findings and to compare results across laboratories. Those methodological issues have mainly been discussed in separate outlets, making difficult to get a grasp on them, and thus this paper aims to address this issue. It will help to provide psychophysiological researchers with recommendations and practical advice concerning experimental designs, data analysis, and data reporting. This will ensure that researchers starting a project with HRV and cardiac vagal tone are well informed regarding methodological considerations in order for their findings to contribute to knowledge advancement in their field. PMID:28265249

Data and graph interpretation practices among preservice science teachers

NASA Astrophysics Data System (ADS)

Bowen, G. Michael; Roth, Wolff-Michael

2005-12-01

The interpretation of data and construction and interpretation of graphs are central practices in science, which, according to recent reform documents, science and mathematics teachers are expected to foster in their classrooms. However, are (preservice) science teachers prepared to teach inquiry with the purpose of transforming and analyzing data, and interpreting graphical representations? That is, are preservice science teachers prepared to teach data analysis and graph interpretation practices that scientists use by default in their everyday work? The present study was designed to answer these and related questions. We investigated the responses of preservice elementary and secondary science teachers to data and graph interpretation tasks. Our investigation shows that, despite considerable preparation, and for many, despite bachelor of science degrees, preservice teachers do not enact the (authentic) practices that scientists routinely do when asked to interpret data or graphs. Detailed analyses are provided of what data and graph interpretation practices actually were enacted. We conclude that traditional schooling emphasizes particular beliefs in the mathematical nature of the universe that make it difficult for many individuals to deal with data possessing the random variation found in measurements of natural phenomena. The results suggest that preservice teachers need more experience in engaging in data and graph interpretation practices originating in activities that provide the degree of variation in and complexity of data present in realistic investigations.

Monitoring a restless volcano: The 2004 eruption of Mount St. Helens

USGS Publications Warehouse

Gardner, C.

2005-01-01

Although the precise course of volcanic activity is difficult to predict, volcanologists are pretty adept at interpreting volcanic signals from well-monitored volcanoes in order to make short-term forecasts. Various monitoring tools record effects to give us warning before eruptions, changes in eruptive behavior during eruptions, or signals that an eruption is ending. Foremost among these tools is seismic monitoring. The character, size, depth and rate of earthquakes are all important to the interpretation of what is happening belowground. The first inkling of renewed activity at Mount St. Helens began in the early hours of Sept. 23, when a seismic swarm - tens to hundreds of earthquakes over days to a week - began beneath the volcano. This article details the obervations made during the eruptive sequence.

Information Extraction of Tourist Geological Resources Based on 3d Visualization Remote Sensing Image

NASA Astrophysics Data System (ADS)

Wang, X.

2018-04-01

Tourism geological resources are of high value in admiration, scientific research and universal education, which need to be protected and rationally utilized. In the past, most of the remote sensing investigations of tourism geological resources used two-dimensional remote sensing interpretation method, which made it difficult for some geological heritages to be interpreted and led to the omission of some information. This aim of this paper is to assess the value of a method using the three-dimensional visual remote sensing image to extract information of geological heritages. skyline software system is applied to fuse the 0.36 m aerial images and 5m interval DEM to establish the digital earth model. Based on the three-dimensional shape, color tone, shadow, texture and other image features, the distribution of tourism geological resources in Shandong Province and the location of geological heritage sites were obtained, such as geological structure, DaiGu landform, granite landform, Volcanic landform, sandy landform, Waterscapes, etc. The results show that using this method for remote sensing interpretation is highly recognizable, making the interpretation more accurate and comprehensive.

Interpreter-mediated diabetes consultations: a qualitative analysis of physician communication practices

PubMed Central

2013-01-01

Background Patient-provider communication, in particular physicians’ ability to listen to their patients, and support them in making difficult lifestyle changes, is an essential component of effective diabetes care. Clinical communication around diabetes can be especially challenging when language barriers are present, and may contribute to poor diabetes management and outcomes. Clinicians need to be aware of and address potential communication difficulties associated with interpreter-mediated consultations. The purpose of our study was to explore how physicians communicate in interpreter-mediated consultations with diabetic patients, and how their communication behaviors may impact diabetes communication and care. Method We analyzed transcripts from 8 audio recorded, outpatient consultations at the Basel University Hospital general medicine outpatient clinic involving Turkish-speaking patients, German-speaking physicians, and Turkish-German interpreters (both community interpreters and family members). Results Clinicians used closed questions when asking about symptoms and glucose control. When providing information and explanation, they spoke in long and complex speech turns. They often directed their speech to interpreters or became sidetracked by family members’ questions or requests for information. Patients’ participation in the consultation was minimal, and limited to brief answers to clinicians’ questions. Conclusions Clinicians need to be aware of common pitfalls that diminish patient-centeredness during interpreter-mediated consultations, and learn strategies to avoid them. Attention to established guidelines on triadic communication is recommended, as is hands-on training with interpreters. PMID:24152539

Spectral signature of alpine snow cover from the Landsat Thematic Mapper

NASA Technical Reports Server (NTRS)

Dozier, Jeff

1989-01-01

In rugged terrain, snow in the shadows can appear darker than soil or vegetation in the sunlight, making it difficult to interpret satellite data images of rugged terrains. This paper discusses methods for using Thematic Mapper (TM) and SPOT data for automatic analyses of alpine snow cover. Typical spectral signatures of the Landsat TM are analyzed for a range of snow types, atmospheric profiles, and topographic illumination conditions. A number of TM images of Sierra Nevada are analyzed to distinguish several classes of snow from other surface covers.

Elastic strain and twist analysis of protein structural data and allostery of the transmembrane channel KcsA

NASA Astrophysics Data System (ADS)

Mitchell, Michael R.; Leibler, Stanislas

2018-05-01

The abundance of available static protein structural data makes the more effective analysis and interpretation of this data a valuable tool to supplement the experimental study of protein mechanics. Structural displacements can be difficult to analyze and interpret. Previously, we showed that strains provide a more natural and interpretable representation of protein deformations, revealing mechanical coupling between spatially distinct sites of allosteric proteins. Here, we demonstrate that other transformations of displacements yield additional insights. We calculate the divergence and curl of deformations of the transmembrane channel KcsA. Additionally, we introduce quantities analogous to bend, splay, and twist deformation energies of nematic liquid crystals. These transformations enable the decomposition of displacements into different modes of deformation, helping to characterize the type of deformation a protein undergoes. We apply these calculations to study the filter and gating regions of KcsA. We observe a continuous path of rotational deformations physically coupling these two regions, and, we propose, underlying the allosteric interaction between these regions. Bend, splay, and twist distinguish KcsA gate opening, filter opening, and filter-gate coupling, respectively. In general, physically meaningful representations of deformations (like strain, curl, bend, splay, and twist) can make testable predictions and yield insights into protein mechanics, augmenting experimental methods and more fully exploiting available structural data.

Clinical assessment of decision-making capacity in acquired brain injury with personality change.

PubMed

Owen, Gareth S; Freyenhagen, Fabian; Martin, Wayne; David, Anthony S

2017-01-01

Assessment of decision-making capacity (DMC) can be difficult in acquired brain injury (ABI) particularly with the syndrome of organic personality disorder (OPD) (the "frontal lobe syndrome"). Clinical neuroscience may help but there are challenges translating its constructs to the decision-making abilities considered relevant by law and ethics. An in-depth interview study of DMC in OPD was undertaken. Six patients were purposefully sampled and rich interview data were acquired for scrutiny using interpretative phenomenological analysis. Interview data revealed that awareness of deficit and thinking about psychological states can be present. However, the awareness of deficit may not be "online" and effectively integrated into decision-making. Without this online awareness of deficit the ability to appreciate or use and weigh information in the process of deciding some matters appeared absent. We argue that the decision-making abilities discussed are: (1) necessary for DMC, (2) threatened by ABI , and (3) assessable at interview. Some advice for practically incorporating these abilities within assessments of DMC in patients with OPD is outlined.

Set-free Markov state model building

NASA Astrophysics Data System (ADS)

Weber, Marcus; Fackeldey, Konstantin; Schütte, Christof

2017-03-01

Molecular dynamics (MD) simulations face challenging problems since the time scales of interest often are much longer than what is possible to simulate; and even if sufficiently long simulations are possible the complex nature of the resulting simulation data makes interpretation difficult. Markov State Models (MSMs) help to overcome these problems by making experimentally relevant time scales accessible via coarse grained representations that also allow for convenient interpretation. However, standard set-based MSMs exhibit some caveats limiting their approximation quality and statistical significance. One of the main caveats results from the fact that typical MD trajectories repeatedly re-cross the boundary between the sets used to build the MSM which causes statistical bias in estimating the transition probabilities between these sets. In this article, we present a set-free approach to MSM building utilizing smooth overlapping ansatz functions instead of sets and an adaptive refinement approach. This kind of meshless discretization helps to overcome the recrossing problem and yields an adaptive refinement procedure that allows us to improve the quality of the model while exploring state space and inserting new ansatz functions into the MSM.

Visualizing tumor evolution with the fishplot package for R.

PubMed

Miller, Christopher A; McMichael, Joshua; Dang, Ha X; Maher, Christopher A; Ding, Li; Ley, Timothy J; Mardis, Elaine R; Wilson, Richard K

2016-11-07

Massively-parallel sequencing at depth is now enabling tumor heterogeneity and evolution to be characterized in unprecedented detail. Tracking these changes in clonal architecture often provides insight into therapeutic response and resistance. In complex cases involving multiple timepoints, standard visualizations, such as scatterplots, can be difficult to interpret. Current data visualization methods are also typically manual and laborious, and often only approximate subclonal fractions. We have developed an R package that accurately and intuitively displays changes in clonal structure over time. It requires simple input data and produces illustrative and easy-to-interpret graphs suitable for diagnosis, presentation, and publication. The simplicity, power, and flexibility of this tool make it valuable for visualizing tumor evolution, and it has potential utility in both research and clinical settings. The fishplot package is available at https://github.com/chrisamiller/fishplot .

Adaptive decision making in a dynamic environment: a test of a sequential sampling model of relative judgment.

PubMed

Vuckovic, Anita; Kwantes, Peter J; Neal, Andrew

2013-09-01

Research has identified a wide range of factors that influence performance in relative judgment tasks. However, the findings from this research have been inconsistent. Studies have varied with respect to the identification of causal variables and the perceptual and decision-making mechanisms underlying performance. Drawing on the ecological rationality approach, we present a theory of the judgment and decision-making processes involved in a relative judgment task that explains how people judge a stimulus and adapt their decision process to accommodate their own uncertainty associated with those judgments. Undergraduate participants performed a simulated air traffic control conflict detection task. Across two experiments, we systematically manipulated variables known to affect performance. In the first experiment, we manipulated the relative distances of aircraft to a common destination while holding aircraft speeds constant. In a follow-up experiment, we introduced a direct manipulation of relative speed. We then fit a sequential sampling model to the data, and used the best fitting parameters to infer the decision-making processes responsible for performance. Findings were consistent with the theory that people adapt to their own uncertainty by adjusting their criterion and the amount of time they take to collect evidence in order to make a more accurate decision. From a practical perspective, the paper demonstrates that one can use a sequential sampling model to understand performance in a dynamic environment, allowing one to make sense of and interpret complex patterns of empirical findings that would otherwise be difficult to interpret using standard statistical analyses. PsycINFO Database Record (c) 2013 APA, all rights reserved.

Perspectives in quantum physics: Epistemological, ontological and pedagogical An investigation into student and expert perspectives on the physical interpretation of quantum mechanics, with implications for modern physics instruction

NASA Astrophysics Data System (ADS)

Baily, Charles Raymond

A common learning goal for modern physics instructors is for students to recognize a difference between the experimental uncertainty of classical physics and the fundamental uncertainty of quantum mechanics. Our studies suggest this notoriously difficult task may be frustrated by the intuitively realist perspectives of introductory students, and a lack of ontological flexibility in their conceptions of light and matter. We have developed a framework for understanding and characterizing student perspectives on the physical interpretation of quantum mechanics, and demonstrate the differential impact on student thinking of the myriad ways instructors approach interpretive themes in their introductory courses. Like expert physicists, students interpret quantum phenomena differently, and these interpretations are significantly influenced by their overall stances on questions central to the so-called measurement problem: Is the wave function physically real, or simply a mathematical tool? Is the collapse of the wave function an ad hoc rule, or a physical transition not described by any equation? Does an electron, being a form of matter, exist as a localized particle at all times? These questions, which are of personal and academic interest to our students, are largely only superficially addressed in our introductory courses, often for fear of opening a Pandora's Box of student questions, none of which have easy answers. We show how a transformed modern physics curriculum (recently implemented at the University of Colorado) may positively impact student perspectives on indeterminacy and wave-particle duality, by making questions of classical and quantum reality a central theme of our course, but also by making the beliefs of our students, and not just those of scientists, an explicit topic of discussion.

Conceptual framework of knowledge management for ethical decision-making support in neonatal intensive care.

PubMed

Frize, Monique; Yang, Lan; Walker, Robin C; O'Connor, Annette M

2005-06-01

This research is built on the belief that artificial intelligence estimations need to be integrated into clinical social context to create value for health-care decisions. In sophisticated neonatal intensive care units (NICUs), decisions to continue or discontinue aggressive treatment are an integral part of clinical practice. High-quality evidence supports clinical decision-making, and a decision-aid tool based on specific outcome information for individual NICU patients will provide significant support for parents and caregivers in making difficult "ethical" treatment decisions. In our approach, information on a newborn patient's likely outcomes is integrated with the physician's interpretation and parents' perspectives into codified knowledge. Context-sensitive content adaptation delivers personalized and customized information to a variety of users, from physicians to parents. The system provides structuralized knowledge translation and exchange between all participants in the decision, facilitating collaborative decision-making that involves parents at every stage on whether to initiate, continue, limit, or terminate intensive care for their infant.

Cognitive function in hot environments: a question of methodology.

PubMed

Gaoua, N

2010-10-01

The physiological responses of thermal stress and its consequences on health have been well documented. However, the effect on cognitive function remains equivocal despite a substantial number of studies conducted in the area. Methodological discrepancies across different studies have made it difficult to conclude whether or not heat exposure per se has an adverse effect upon cognitive function and under what specific environmental and physiological conditions these alterations appear. This article gives an overview of the different confounding factors that have made it difficult to make conclusive interpretations. In addition, the current state of knowledge is presented and discussed with reference to the Global Workspace theory. Although previously presented conclusions are promising, much remains to be completed before understanding the mechanisms that could explain the relationship between heat exposure and cognitive function. Finally, recommendations are presented for further research in this area. © 2010 John Wiley & Sons A/S.

COMSKIL Communication Training in Oncology-Adaptation to German Cancer Care Settings.

PubMed

Hartung, Tim J; Kissane, David; Mehnert, Anja

2018-01-01

Medical communication is a skill which can be learned and taught and which can substantially improve treatment outcomes, especially if patients' communication preferences are taken into account. Here, we give an overview of communication training research and outline the COMSKIL program as a state-of-the-art communication skills training in oncology. COMSKIL has a solid theoretical foundation and teaches core elements of medical communication in up to ten fully operationalized modules. These address typical situations ranging from breaking bad news to responding to difficult emotions, shared decision-making, and communicating via interpreters.

Psychiatric side effects of antihypertensive drugs other than reserpine.

PubMed

Paykel, E S; Fleminger, R; Watson, J P

1982-02-01

The psychiatric side effects of the major antihypertensive drugs other than reserpine are reviewed, including centrally acting drugs such as methyldopa and clonidine, peripheral adrenergic drugs such as guanethidine, beta-adrenoceptor blockers such as propranolol, and diuretics. Problems with differential diagnosis and with the interpretation of case reports make assessment of psychiatric side effects difficult. Sedation and sleep disturbances are the most common side effects, occurring with methyldopa, clonidine, and propranolol. Only methyldopa is clearly associated with depression. Other reported effects are toxic confusional states and psychotic reactions. These are rare, however, and no clear patterns of development have been recognized.

The development of a modified spectral ripple test.

PubMed

Aronoff, Justin M; Landsberger, David M

2013-08-01

Poor spectral resolution can be a limiting factor for hearing impaired listeners, particularly for complex listening tasks such as speech understanding in noise. Spectral ripple tests are commonly used to measure spectral resolution, but these tests contain a number of potential confounds that can make interpretation of the results difficult. To measure spectral resolution while avoiding those confounds, a modified spectral ripple test with dynamically changing ripples was created, referred to as the spectral-temporally modulated ripple test (SMRT). This paper describes the SMRT and provides evidence that it is sensitive to changes in spectral resolution.

Acute toxicities of toxaphene and endrin to larvae of seven species of amphibians

USGS Publications Warehouse

Hall, R.J.; Swineford, D.M.

1981-01-01

Seven species of amphibian larvae were exposed to toxaphene and endrin in a continuous-flow dosing system to determine differences in sensitivity to the two compounds, EC50 and LC50 estimates varied from those for Rana sphenocephala by no more than one order of magnitude when calculated on the basis of intended concentrations. Removal of pesticides from water by the test animals was significant and it makes interpretation of results difficult. Continuous-flow toxicity tests conflict with the adaptations of amphibian larvae for static water; use of such tests for amphibians requires further evaluation.

Proteomics, lipidomics, metabolomics: a mass spectrometry tutorial from a computer scientist's point of view.

PubMed

Smith, Rob; Mathis, Andrew D; Ventura, Dan; Prince, John T

2014-01-01

For decades, mass spectrometry data has been analyzed to investigate a wide array of research interests, including disease diagnostics, biological and chemical theory, genomics, and drug development. Progress towards solving any of these disparate problems depends upon overcoming the common challenge of interpreting the large data sets generated. Despite interim successes, many data interpretation problems in mass spectrometry are still challenging. Further, though these challenges are inherently interdisciplinary in nature, the significant domain-specific knowledge gap between disciplines makes interdisciplinary contributions difficult. This paper provides an introduction to the burgeoning field of computational mass spectrometry. We illustrate key concepts, vocabulary, and open problems in MS-omics, as well as provide invaluable resources such as open data sets and key search terms and references. This paper will facilitate contributions from mathematicians, computer scientists, and statisticians to MS-omics that will fundamentally improve results over existing approaches and inform novel algorithmic solutions to open problems.

Models of volcanic eruption hazards

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wohletz, K.H.

1992-01-01

Volcanic eruptions pose an ever present but poorly constrained hazard to life and property for geothermal installations in volcanic areas. Because eruptions occur sporadically and may limit field access, quantitative and systematic field studies of eruptions are difficult to complete. Circumventing this difficulty, laboratory models and numerical simulations are pivotal in building our understanding of eruptions. For example, the results of fuel-coolant interaction experiments show that magma-water interaction controls many eruption styles. Applying these results, increasing numbers of field studies now document and interpret the role of external water eruptions. Similarly, numerical simulations solve the fundamental physics of high-speed fluidmore » flow and give quantitative predictions that elucidate the complexities of pyroclastic flows and surges. A primary goal of these models is to guide geologists in searching for critical field relationships and making their interpretations. Coupled with field work, modeling is beginning to allow more quantitative and predictive volcanic hazard assessments.« less

Determination and interpretation of the optical constants for solar cell materials

NASA Astrophysics Data System (ADS)

Fujiwara, Hiroyuki; Fujimoto, Shohei; Tamakoshi, Masato; Kato, Masato; Kadowaki, Hideyuki; Miyadera, Tetsuhiko; Tampo, Hitoshi; Chikamatsu, Masayuki; Shibata, Hajime

2017-11-01

Solar cell materials in thin film form often exhibit quite rough surface, which makes the accurate determination of the optical constants using spectroscopic ellipsometry (SE) quite difficult. In this study, we investigate the effect of the rough surface on the SE analysis and establish an analysis procedure, which is quite helpful for the correction of the underestimated roughness contribution. As examples, the roughness analyses for CuInSe2 and CH3NH3PbI3 hybrid-perovskite thin films are presented. Moreover, to interpret the dielectric functions of emerging solar cell materials, such as CH3NH3PbI3 and Cu2ZnSnSe4, the optical transition analyses are performed based on density functional theory (DFT). The excellent agreement observed between the experimental and DFT results allows the detailed assignment of the transition peaks, confirming the importance of DFT for revealing fundamental optical characteristics.

Biasing, Acquisition and Interpretation of a Dense Langmuir Probe Array in NSTX

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jaworski, M. A.; Kallman, J.; Kaita, R.

2010-09-22

A dense array of 99 Langmuir probes has been installed in the lower divertor region of the National Spherical Torus Experiments (NSTX). This array is instrumented with a system of elec- tronics that allows flexibility in the choice of probes to bias as well as the type of measurement (including standard swept, single probe, triple probe and operation as passive floating potential and scrape-off-layer (SOL) current monitors). The use of flush-mounted probes requires careful inter- pretation. The time dependent nature of the SOL makes swept-probe traces difficult to interpret. To overcome these challenges, the single- and triple-Langmuir probe signals aremore » used in comple- mentary fashion to determine the temperature and density at the probe location. A comparison to mid-plane measurements is made. Work is supported by DOE contracts DE-AC02-09CHI1466 and DE-PS02-07ER07-29.« less

Recent Changes of Classification for Squamous Intraepithelial Lesions of the Head and Neck.

PubMed

Cho, Kyung-Ja; Song, Joon Seon

2018-05-18

- Interpretation of atypical squamous lesions of the head and neck has always been a nettlesome task for pathologists. Moreover, many different grading systems for squamous intraepithelial lesions have been proposed in past decades. The recent World Health Organization 2017 classification presents 2 types of 2-tier systems for laryngeal and oral precursor lesions. - To review the recent changes in classification and the clinical significance for squamous intraepithelial lesions of the head and neck. - Personal experience and data from the literature. - The 2-tier grading system for laryngeal dysplasia, presented by World Health Organization in 2017, is expected to improve diagnostic reproducibility and clinical implication. However, the diagnostic criteria for low-grade dysplasia do not distinguish it clearly from basal cell hyperplasia. The World Health Organization 2017 classification of oral epithelial dysplasia remains unclear, and complicated and variable grading systems still make head and neck intraepithelial lesions difficult to interpret.

Models of volcanic eruption hazards

NASA Astrophysics Data System (ADS)

Wohletz, K. H.

Volcanic eruptions pose an ever present but poorly constrained hazard to life and property for geothermal installations in volcanic areas. Because eruptions occur sporadically and may limit field access, quantitative and systematic field studies of eruptions are difficult to complete. Circumventing this difficulty, laboratory models and numerical simulations are pivotal in building our understanding of eruptions. For example, the results of fuel-coolant interaction experiments show that magma-water interaction controls many eruption styles. Applying these results, increasing numbers of field studies now document and interpret the role of external water eruptions. Similarly, numerical simulations solve the fundamental physics of high-speed fluid flow and give quantitative predictions that elucidate the complexities of pyroclastic flows and surges. A primary goal of these models is to guide geologists in searching for critical field relationships and making their interpretations. Coupled with field work, modeling is beginning to allow more quantitative and predictive volcanic hazard assessments.

Hematology and biochemistry reference intervals for Ontario commercial nursing pigs close to the time of weaning

PubMed Central

Perri, Amanda M.; O’Sullivan, Terri L.; Harding, John C.S.; Wood, R. Darren; Friendship, Robert M.

2017-01-01

The evaluation of pig hematology and biochemistry parameters is rarely done largely due to the costs associated with laboratory testing and labor, and the limited availability of reference intervals needed for interpretation. Within-herd and between-herd biological variation of these values also make it difficult to establish reference intervals. Regardless, baseline reference intervals are important to aid veterinarians in the interpretation of blood parameters for the diagnosis and treatment of diseased swine. The objective of this research was to provide reference intervals for hematology and biochemistry parameters of 3-week-old commercial nursing piglets in Ontario. A total of 1032 pigs lacking clinical signs of disease from 20 swine farms were sampled for hematology and iron panel evaluation, with biochemistry analysis performed on a subset of 189 randomly selected pigs. The 95% reference interval, mean, median, range, and 90% confidence intervals were calculated for each parameter. PMID:28373729

Visualizing Parallel Computer System Performance

NASA Technical Reports Server (NTRS)

Malony, Allen D.; Reed, Daniel A.

1988-01-01

Parallel computer systems are among the most complex of man's creations, making satisfactory performance characterization difficult. Despite this complexity, there are strong, indeed, almost irresistible, incentives to quantify parallel system performance using a single metric. The fallacy lies in succumbing to such temptations. A complete performance characterization requires not only an analysis of the system's constituent levels, it also requires both static and dynamic characterizations. Static or average behavior analysis may mask transients that dramatically alter system performance. Although the human visual system is remarkedly adept at interpreting and identifying anomalies in false color data, the importance of dynamic, visual scientific data presentation has only recently been recognized Large, complex parallel system pose equally vexing performance interpretation problems. Data from hardware and software performance monitors must be presented in ways that emphasize important events while eluding irrelevant details. Design approaches and tools for performance visualization are the subject of this paper.

Readmission prediction via deep contextual embedding of clinical concepts.

PubMed

Xiao, Cao; Ma, Tengfei; Dieng, Adji B; Blei, David M; Wang, Fei

2018-01-01

Hospital readmission costs a lot of money every year. Many hospital readmissions are avoidable, and excessive hospital readmissions could also be harmful to the patients. Accurate prediction of hospital readmission can effectively help reduce the readmission risk. However, the complex relationship between readmission and potential risk factors makes readmission prediction a difficult task. The main goal of this paper is to explore deep learning models to distill such complex relationships and make accurate predictions. We propose CONTENT, a deep model that predicts hospital readmissions via learning interpretable patient representations by capturing both local and global contexts from patient Electronic Health Records (EHR) through a hybrid Topic Recurrent Neural Network (TopicRNN) model. The experiment was conducted using the EHR of a real world Congestive Heart Failure (CHF) cohort of 5,393 patients. The proposed model outperforms state-of-the-art methods in readmission prediction (e.g. 0.6103 ± 0.0130 vs. second best 0.5998 ± 0.0124 in terms of ROC-AUC). The derived patient representations were further utilized for patient phenotyping. The learned phenotypes provide more precise understanding of readmission risks. Embedding both local and global context in patient representation not only improves prediction performance, but also brings interpretable insights of understanding readmission risks for heterogeneous chronic clinical conditions. This is the first of its kind model that integrates the power of both conventional deep neural network and the probabilistic generative models for highly interpretable deep patient representation learning. Experimental results and case studies demonstrate the improved performance and interpretability of the model.

Paleoenvironmental interpretation of section of Rosario Formation in Ensenada, Baja California, Mexico

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tellez-Duarte, M.A.; Ferman-Almada, J.L.

In contrast to previous interpretations of the Rosario Formation in other parts of Baja California, a stratigraphic section 6 km north of Ensenada, Baja California, Mexico, contains evidences for deposition in shallow waters during a regressive event in a steep slope basin. Among the sedimentary evidence, the section shows a coarse, shoaling-upward sequence, with high-angle cross-stratification and planar bed lamination. Load structures with a westward orientation were found only at the base. The fossils assemblages support the same shoaling-upward interpretation as the sedimentary evidence, with ammonoids and deposit feeder trace fossils (such as Chondrites) at the bottom to mollusks andmore » suspension feeder trace fossils (such as Scolicia and Ophiomorpha, characteristic of shallower waters) at the top. This sedimentologic and paleontologic evidence suggests nearshore to beach coastal deposits. The contact between the section and a discontinuous thin limestone bed at the top of the section shows an unconformity. The absence of well-preserved fossils makes this limestone difficult to date, but the lithology is similar to that of Paleocene Sepultura Formation limestones.« less

Surgeon-level reporting presented by funnel plot is understood by doctors but inaccurately interpreted by members of the public.

PubMed

Bhalla, Ashish; Mehrotra, Prerna; Amawi, Falah; Lund, Jonathan N

2015-01-01

Risk-adjusted outcome data for general surgeons practicing in the United Kingdom were published for the first time in 2013 with the aim of increasing transparency, improving standards, and providing the public with information to aid decision making. Most specialties used funnel plots to present their data. We assess the ability of members of the public (MoP), medical students, nonsurgical doctors (NSD), and surgeons to understand risk-adjusted surgical outcome data. A fictitious outcome dataset was created and presented in the form of a funnel plot to 10 participants from each of the aforementioned group. Standard explanatory text was provided. Each participant was given 5 minutes to review the funnel plot and complete a questionnaire. For each question, there was only 1 correct answer. Completion rate was 100% (n = 40). No difference existed between NSD and surgeons. A significant difference for identification of the "worst performing surgeon" was noted between surgeons and MoP (p < 0.01) and between NSD and MoP (p < 0.01). Half of medical students and MoP claimed they would use this information to aid decision making compared with 80% of doctors. MoP reported the funnel plot significantly "more difficult" to interpret than surgeons did (p < 0.01) and NSD (p < 0.01). MoP found these data significantly more "difficult to understand" and were less likely to both spot "outliers" and use this data to inform decisions than doctors. Surgeons should be aware that outcome data may require an alternative method of presentation to be understood by MoP. Copyright © 2015 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

The emergency patient's participation in medical decision-making.

PubMed

Wang, Li-Hsiang; Goopy, Suzanne; Lin, Chun-Chih; Barnard, Alan; Han, Chin-Yen; Liu, Hsueh-Erh

2016-09-01

The purpose of this research was to explore the medical decision-making processes of patients in emergency departments. Studies indicate that patients should be given enough time to acquire relevant information and receive adequate support when they need to make medical decisions. It is difficult to satisfy these requirements in emergency situations. Limited research has addressed the topic of decision-making among emergency patients. This qualitative study used a broadly defined grounded theory approach to explore decision-making in an emergency department in Taiwan. Thirty emergency patients were recruited between June and December 2011 for semi-structured interviews that were audio-taped and transcribed verbatim. The study identified three stages in medical decision-making by emergency patients: predecision (interpreting the problem); decision (a balancing act) and postdecision (reclaiming the self). Transference was identified as the core category and pattern of behaviour through which patients resolved their main concerns. This transference around decision-making represents a type of bricolage. The findings fill a gap in knowledge about the decision-making process among emergency patients. The results inform emergency professionals seeking to support patients faced with complex medical decision-making and suggest an emphasis on informed patient decision-making, advocacy, patient-centred care and in-service education of health staff. © 2016 John Wiley & Sons Ltd.

What Makes Difficult History Difficult?

ERIC Educational Resources Information Center

Gross, Magdalena H.; Terra, Luke

2018-01-01

All modern nation-states have periods of difficult history that teachers fail to address or address inadequately. The authors present a framework for defining difficult histories and understanding what makes them difficult. These events 1) are central to a nation's history, 2) contradict accepted histories or values, 3) connect with present…

Distinguishing Between Supra-Arcade Downflows and Plasmoids

NASA Technical Reports Server (NTRS)

Savage, Sabrina

2015-01-01

Supra-arcade downflows (SADs) and downflowing loops (SADLs), observed as sunward-traveling voids and thin flux tubes in the current sheet region above developing flare arcades, are considered indicators of magnetic reconnection fueling long­-duration solar eruptions. These flows are located in regions of very low signal-­to-noise in the corona where high cadence magnetic field measurements are not yet achievable, making observations difficult to fully interpret with respect to reconnection. Several models have been developed to explain their characteristics and behaviors, but most do not successfully recreate the observations. We will present a variety of downflow observations and provide comparisons to a number of the more prominent models.

An Intelligent Active Video Surveillance System Based on the Integration of Virtual Neural Sensors and BDI Agents

NASA Astrophysics Data System (ADS)

Gregorio, Massimo De

In this paper we present an intelligent active video surveillance system currently adopted in two different application domains: railway tunnels and outdoor storage areas. The system takes advantages of the integration of Artificial Neural Networks (ANN) and symbolic Artificial Intelligence (AI). This hybrid system is formed by virtual neural sensors (implemented as WiSARD-like systems) and BDI agents. The coupling of virtual neural sensors with symbolic reasoning for interpreting their outputs, makes this approach both very light from a computational and hardware point of view, and rather robust in performances. The system works on different scenarios and in difficult light conditions.

Correlation, necessity, and sufficiency: Common errors in the scientific reasoning of undergraduate students for interpreting experiments.

PubMed

Coleman, Aaron B; Lam, Diane P; Soowal, Lara N

2015-01-01

Gaining an understanding of how science works is central to an undergraduate education in biology and biochemistry. The reasoning required to design or interpret experiments that ask specific questions does not come naturally, and is an essential part of the science process skills that must be learned for an understanding of how scientists conduct research. Gaps in these reasoning skills make it difficult for students to become proficient in reading primary scientific literature. In this study, we assessed the ability of students in an upper-division biochemistry laboratory class to use the concepts of correlation, necessity, and sufficiency in interpreting experiments presented in a format and context that is similar to what they would encounter when reading a journal article. The students were assessed before and after completion of a laboratory module where necessary vs. sufficient reasoning was used to design and interpret experiments. The assessment identified two types of errors that were commonly committed by students when interpreting experimental data. When presented with an experiment that only establishes a correlation between a potential intermediate and a known effect, students frequently interpreted the intermediate as being sufficient (causative) for the effect. Also, when presented with an experiment that tests only necessity for an intermediate, they frequently made unsupported conclusions about sufficiency, and vice versa. Completion of the laboratory module and instruction in necessary vs. sufficient reasoning showed some promise for addressing these common errors. © 2015 The International Union of Biochemistry and Molecular Biology.

Faculty Teaching Diversity through Difficult Dialogues: Stories of Challenges and Success

ERIC Educational Resources Information Center

Gayles, Joy Gaston; Kelly, Bridget Turner; Grays, Shaefny; Zhang, Jing Jing; Porter, Kamaria P.

2015-01-01

Teaching diversity courses in graduate preparation programs is likely to trigger difficult dialogues that evoke a range of emotional responses. Difficult dialogues on diversity topics must be managed effectively in order to enhance multicultural competence. This interpretive study examined the experiences of faculty who teach diversity courses in…

[Microarray CGH: principle and use for constitutional disorders].

PubMed

Sanlaville, D; Lapierre, J M; Coquin, A; Turleau, C; Vermeesch, J; Colleaux, L; Borck, G; Vekemans, M; Aurias, A; Romana, S P

2005-10-01

Chips technology has allowed to miniaturize process making possible to realize in one step and using the same device a lot of chemical reactions. The application of this technology to molecular cytogenetics resulted in the development of comparative genomic hybridization (CGH) on microarrays technique. Using this technique it is possible to detect very small genetic imbalances anywhere in the genome. Its usefulness has been well documented in cancer and more recently in constitutional disorders. In particular it has been used to detect interstitial and subtelomeric submicroscopic imbalances, to characterize their size at the molecular level or to define the breakpoints of translocation. The challenge today is to transfer this technology in laboratory medicine. Nevertheless this technology remains expensive and the existence of numerous sequence polymorphisms makes its interpretation difficult. Finally its is unlikely that it will make karyotyping obsolete as it does not allow to detect balanced rearrangements which after meiotic segregation might result in genome imbalance in the progeny.

Inferring data-specific micro-RNA function through the joint ranking of micro-RNA and pathways from matched micro-RNA and gene expression data.

PubMed

Patrick, Ellis; Buckley, Michael; Müller, Samuel; Lin, David M; Yang, Jean Y H

2015-09-01

In practice, identifying and interpreting the functional impacts of the regulatory relationships between micro-RNA and messenger-RNA is non-trivial. The sheer scale of possible micro-RNA and messenger-RNA interactions can make the interpretation of results difficult. We propose a supervised framework, pMim, built upon concepts of significance combination, for jointly ranking regulatory micro-RNA and their potential functional impacts with respect to a condition of interest. Here, pMim directly tests if a micro-RNA is differentially expressed and if its predicted targets, which lie in a common biological pathway, have changed in the opposite direction. We leverage the information within existing micro-RNA target and pathway databases to stabilize the estimation and annotation of micro-RNA regulation making our approach suitable for datasets with small sample sizes. In addition to outputting meaningful and interpretable results, we demonstrate in a variety of datasets that the micro-RNA identified by pMim, in comparison to simpler existing approaches, are also more concordant with what is described in the literature. This framework is implemented as an R function, pMim, in the package sydSeq available from http://www.ellispatrick.com/r-packages. jean.yang@sydney.edu.au Supplementary data are available at Bioinformatics online. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Unlocking interpretation in near infrared multivariate calibrations by orthogonal partial least squares.

PubMed

Stenlund, Hans; Johansson, Erik; Gottfries, Johan; Trygg, Johan

2009-01-01

Near infrared spectroscopy (NIR) was developed primarily for applications such as the quantitative determination of nutrients in the agricultural and food industries. Examples include the determination of water, protein, and fat within complex samples such as grain and milk. Because of its useful properties, NIR analysis has spread to other areas such as chemistry and pharmaceutical production. NIR spectra consist of infrared overtones and combinations thereof, making interpretation of the results complicated. It can be very difficult to assign peaks to known constituents in the sample. Thus, multivariate analysis (MVA) has been crucial in translating spectral data into information, mainly for predictive purposes. Orthogonal partial least squares (OPLS), a new MVA method, has prediction and modeling properties similar to those of other MVA techniques, e.g., partial least squares (PLS), a method with a long history of use for the analysis of NIR data. OPLS provides an intrinsic algorithmic improvement for the interpretation of NIR data. In this report, four sets of NIR data were analyzed to demonstrate the improved interpretation provided by OPLS. The first two sets included simulated data to demonstrate the overall principles; the third set comprised a statistically replicated design of experiments (DoE), to demonstrate how instrumental difference could be accurately visualized and correctly attributed to Wood's anomaly phenomena; the fourth set was chosen to challenge the MVA by using data relating to powder mixing, a crucial step in the pharmaceutical industry prior to tabletting. Improved interpretation by OPLS was demonstrated for all four examples, as compared to alternative MVA approaches. It is expected that OPLS will be used mostly in applications where improved interpretation is crucial; one such area is process analytical technology (PAT). PAT involves fewer independent samples, i.e., batches, than would be associated with agricultural applications; in addition, the Food and Drug Administration (FDA) demands "process understanding" in PAT. Both these issues make OPLS the ideal tool for a multitude of NIR calibrations. In conclusion, OPLS leads to better interpretation of spectrometry data (e.g., NIR) and improved understanding facilitates cross-scientific communication. Such improved knowledge will decrease risk, with respect to both accuracy and precision, when using NIR for PAT applications.

Nostradamus (1503-66)

NASA Astrophysics Data System (ADS)

Murdin, P.

2000-11-01

Doctor, astrologer, born in St Rémy, France. Took on the role of a prophet and wrote Centuries, a collection of predictions in rhyme (1555-8). The predictions are expressed in obscure and enigmatic terms, which are both difficult to interpret and open to many interpretations, and so can be interpreted as successful prophesies, including what Catherine of Medici interpreted as the manner of deat...

Post-decision biases reveal a self-consistency principle in perceptual inference.

PubMed

Luu, Long; Stocker, Alan A

2018-05-15

Making a categorical judgment can systematically bias our subsequent perception of the world. We show that these biases are well explained by a self-consistent Bayesian observer whose perceptual inference process is causally conditioned on the preceding choice. We quantitatively validated the model and its key assumptions with a targeted set of three psychophysical experiments, focusing on a task sequence where subjects first had to make a categorical orientation judgment before estimating the actual orientation of a visual stimulus. Subjects exhibited a high degree of consistency between categorical judgment and estimate, which is difficult to reconcile with alternative models in the face of late, memory related noise. The observed bias patterns resemble the well-known changes in subjective preferences associated with cognitive dissonance, which suggests that the brain's inference processes may be governed by a universal self-consistency constraint that avoids entertaining 'dissonant' interpretations of the evidence. © 2018, Luu et al.

Scientific and conceptual flaws of coercive treatment models in addiction.

PubMed

Uusitalo, Susanne; van der Eijk, Yvette

2016-01-01

In conceptual debates on addiction, neurobiological research has been used to support the idea that addicted drug users lack control over their addiction-related actions. In some interpretations, this has led to coercive treatment models, in which, the purpose is to 'restore' control. However, neurobiological studies that go beyond what is typically presented in conceptual debates paint a different story. In particular, they indicate that though addiction has neurobiological manifestations that make the addictive behaviour difficult to control, it is possible for individuals to reverse these manifestations through their own efforts. Thus, addicted individuals should not be considered incapable of making choices voluntarily, simply on the basis that addiction has neurobiological manifestations, and coercive treatment models of addiction should be reconsidered in this respect. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Experience and Sentence Processing: Statistical Learning and Relative Clause Comprehension

PubMed Central

Wells, Justine B.; Christiansen, Morten H.; Race, David S.; Acheson, Daniel J.; MacDonald, Maryellen C.

2009-01-01

Many explanations of the difficulties associated with interpreting object relative clauses appeal to the demands that object relatives make on working memory. MacDonald and Christiansen (2002) pointed to variations in reading experience as a source of differences, arguing that the unique word order of object relatives makes their processing more difficult and more sensitive to the effects of previous experience than the processing of subject relatives. This hypothesis was tested in a large-scale study manipulating reading experiences of adults over several weeks. The group receiving relative clause experience increased reading speeds for object relatives more than for subject relatives, whereas a control experience group did not. The reading time data were compared to performance of a computational model given different amounts of experience. The results support claims for experience-based individual differences and an important role for statistical learning in sentence comprehension processes. PMID:18922516

Bone Sarcoma Pathology: Diagnostic Approach for Optimal Therapy.

PubMed

Rosenberg, Andrew E

2017-01-01

The pathologic interpretation of malignant bone tumors is one of the more challenging areas in surgical pathology. This is based on the reality that primary bone sarcomas are uncommon, demonstrate significant morphologic heterogeneity, and have a broad spectrum of biology. Accordingly, it is difficult for pathologists to acquire the necessary experience to confidently and accurately diagnose bone sarcomas. The task is further complicated by the fact that it requires the integration of clinical and radiologic information into the diagnostic process. Lastly, molecular aberrations in sarcomas are being newly discovered and their identification is often critical to make specific diagnoses. The pathologist's role in guiding optimal treatment in biopsy specimens is to make an accurate diagnosis and provide the grade and molecular aberrations when appropriate. The pathology report of resected tumors must confirm this information and assess the surgical resection margins and the percentage of necrosis if the sarcoma has been treated with neoadjuvant systemic therapy.

Patents and the obligation to protect health: examining the significance of human rights considerations in the protection of pharmaceutical patents.

PubMed

Owoeye, Olasupo Ayodeji

2014-06-01

This article discusses the human right to health in the context of patent protection and access to medicines. It considers the limitations in international human rights law, especially in relation to socioeconomic rights, that make it difficult for the right to health to be a potent justification for derogation from trade or intellectual property agreements. It concludes by taking the view that while the right to health may be somewhat unenforceable in international law, its close association with enforceable rights such as the right to life can be a legitimate basis for making maximum use of the flexibilities in the international intellectual property regime to protect public health. The article takes the view that trade and intellectual property agreements must be interpreted in a way that endeavours as much as possible to resolve any seeming inconsistency with the right to health.

Bias and sensitivity in the placement of fossil taxa resulting from interpretations of missing data.

PubMed

Sansom, Robert S

2015-03-01

The utility of fossils in evolutionary contexts is dependent on their accurate placement in phylogenetic frameworks, yet intrinsic and widespread missing data make this problematic. The complex taphonomic processes occurring during fossilization can make it difficult to distinguish absence from non-preservation, especially in the case of exceptionally preserved soft-tissue fossils: is a particular morphological character (e.g., appendage, tentacle, or nerve) missing from a fossil because it was never there (phylogenetic absence), or just happened to not be preserved (taphonomic loss)? Missing data have not been tested in the context of interpretation of non-present anatomy nor in the context of directional shifts and biases in affinity. Here, complete taxa, both simulated and empirical, are subjected to data loss through the replacement of present entries (1s) with either missing (?s) or absent (0s) entries. Both cause taxa to drift down trees, from their original position, toward the root. Absolute thresholds at which downshift is significant are extremely low for introduced absences (two entries replaced, 6% of present characters). The opposite threshold in empirical fossil taxa is also found to be low; two absent entries replaced with presences causes fossil taxa to drift up trees. As such, only a few instances of non-preserved characters interpreted as absences will cause fossil organisms to be erroneously interpreted as more primitive than they were in life. This observed sensitivity to coding non-present morphology presents a problem for all evolutionary studies that attempt to use fossils to reconstruct rates of evolution or unlock sequences of morphological change. Stem-ward slippage, whereby fossilization processes cause organisms to appear artificially primitive, appears to be a ubiquitous and problematic phenomenon inherent to missing data, even when no decay biases exist. Absent characters therefore require explicit justification and taphonomic frameworks to support their interpretation. © The Author(s) 2014. Published by Oxford University Press, on behalf of the Society of Systematic Biologists.

Post-mortem clinical pharmacology

PubMed Central

Ferner, R E

2008-01-01

Clinical pharmacology assumes that deductions can be made about the concentrations of drugs from a knowledge of the pharmacokinetic parameters in an individual; and that the effects are related to the measured concentration. Post-mortem changes render the assumptions of clinical pharmacology largely invalid, and make the interpretation of concentrations measured in post-mortem samples difficult or impossible. Qualitative tests can show the presence of substances that were not present in life, and can fail to detect substances that led to death. Quantitative analysis is subject to error in itself, and because post-mortem concentrations vary in largely unpredictable ways with the site and time of sampling, as a result of the phenomenon of post-mortem redistribution. Consequently, compilations of ‘lethal concentrations’ are misleading. There is a lack of adequate studies of the true relationship between fatal events and the concentrations that can be measured subsequently, but without such studies, clinical pharmacologists and others should be wary of interpreting post-mortem measurements. PMID:18637886

Academic detailing can play a key role in assessing and implementing comparative effectiveness research findings.

PubMed

Fischer, Michael A; Avorn, Jerry

2012-10-01

Comparative effectiveness research evaluates the relative effectiveness, safety, and value of competing treatment options in clinically realistic settings. Such evaluations can be methodologically complex and difficult to interpret. There will be a growing need for critical evaluation of comparative effectiveness studies to assess the adequacy of their design and to put new information into a broader context. Equally important, this knowledge will have to be communicated to clinicians in a way that will actually change practice. We identify three challenges to effective dissemination of comparative effectiveness research findings: the difficulty of interpreting comparative effectiveness research data, the need for trusted sources of information, and the challenge of turning research results into clinical action. We suggest that academic detailing-direct outreach education that gives clinicians an accurate and unbiased synthesis of the best evidence for practice in a given clinical area-can translate comparative effectiveness research findings into actions that improve health care decision making and patient outcomes.

Integrating individual movement behaviour into dispersal functions.

PubMed

Heinz, Simone K; Wissel, Christian; Conradt, Larissa; Frank, Karin

2007-04-21

Dispersal functions are an important tool for integrating dispersal into complex models of population and metapopulation dynamics. Most approaches in the literature are very simple, with the dispersal functions containing only one or two parameters which summarise all the effects of movement behaviour as for example different movement patterns or different perceptual abilities. The summarising nature of these parameters makes assessing the effect of one particular behavioural aspect difficult. We present a way of integrating movement behavioural parameters into a particular dispersal function in a simple way. Using a spatial individual-based simulation model for simulating different movement behaviours, we derive fitting functions for the functional relationship between the parameters of the dispersal function and several details of movement behaviour. This is done for three different movement patterns (loops, Archimedean spirals, random walk). Additionally, we provide measures which characterise the shape of the dispersal function and are interpretable in terms of landscape connectivity. This allows an ecological interpretation of the relationships found.

Medico-economic evaluation of healthcare products. Methodology for defining a significant impact on French health insurance costs and selection of benchmarks for interpreting results.

PubMed

Dervaux, Benoît; Baseilhac, Eric; Fagon, Jean-Yves; Biot, Claire; Blachier, Corinne; Braun, Eric; Debroucker, Frédérique; Detournay, Bruno; Ferretti, Carine; Granger, Muriel; Jouan-Flahault, Chrystel; Lussier, Marie-Dominique; Meyer, Arlette; Muller, Sophie; Pigeon, Martine; De Sahb, Rima; Sannié, Thomas; Sapède, Claudine; Vray, Muriel

2014-01-01

Decree No. 2012-1116 of 2 October 2012 on medico-economic assignments of the French National Authority for Health (Haute autorité de santé, HAS) significantly alters the conditions for accessing the health products market in France. This paper presents a theoretical framework for interpreting the results of the economic evaluation of health technologies and summarises the facts available in France for developing benchmarks that will be used to interpret incremental cost-effectiveness ratios. This literature review shows that it is difficult to determine a threshold value but it is also difficult to interpret then incremental cost effectiveness ratio (ICER) results without a threshold value. In this context, round table participants favour a pragmatic approach based on "benchmarks" as opposed to a threshold value, based on an interpretative and normative perspective, i.e. benchmarks that can change over time based on feedback. © 2014 Société Française de Pharmacologie et de Thérapeutique.

Distant Galaxy Clusters Hosting Extreme Central Galaxies

NASA Astrophysics Data System (ADS)

McDonald, Michael

2014-09-01

The recently-discovered Phoenix cluster harbors the most star-forming central cluster galaxy of any cluster in the known Universe, by nearly a factor of 10. This extreme system appears to be fulfilling early cooling flow predictions, although the lack of similar systems makes any interpretation difficult. In an attempt to find other "Phoenix-like" clusters, we have cross-correlated archival all-sky surveys (in which Phoenix was detected) and isolated 4 similarly-extreme systems which are also coincident in position and redshift with an overdensity of red galaxies. We propose here to obtain Chandra observations of these extreme, Phoenix-like systems, in order to confirm them as relaxed, rapidly-cooling galaxy clusters.

Gamma Radiation from PSR B1055-52

NASA Technical Reports Server (NTRS)

Thompson, D. J.; Bailes, M.; Bertsch, D. L.; Cordes, J.; DAmico, N. D.; Esposito, J. A.; Finley, J.; Hartman, R. C.; Hermsen, W.; Kanbach, G.;

Achieving trustworthiness in qualitative research: a pan-paradigmatic perspective.

PubMed

Williams, Elizabeth Nutt; Morrow, Susan L

2009-07-01

In this article, as two researchers from different traditions in qualitative research (consensual qualitative research and grounded theory), the authors present their shared views on the critical elements of trustworthiness in qualitative data. In addition to making specific recommendations about the integrity of data, the balance between participant meaning and researcher interpretation, and clear communication and application of the findings, they identify ways in which these issues are difficult to negotiate within and across different qualitative approaches. The authors present examples from various qualitative studies, emphasize the need for a shared language to reduce confusion between qualitative traditions and with researchers from a more strictly quantitative orientation, and recommend particular approaches to establishing trustworthiness in qualitative research.

Differences in the molecular biology of adenocarcinoma of the esophagus, gastric cardia, and upper gastric third.

PubMed

Lehmann, Kuno; Schneider, Paul M

2010-01-01

Adenocarcinoma of the distal esophagus, gastric cardia, and upper gastric third are grouped in type I-III by the Siewert classification. This classification is based on the endoscopic localisation of the tumor center, and is the most important diagnostic tool to group these tumors. On a molecular level, there is currently no marker that would allow to differentiate the three different types. Furthermore, the Siewert classification was not uniformly used in the recent literature, making interpretation and generalization of these results difficult. However, several potential targets have been identified that may help to separate these tumors by molecular markers, and are summarized in this chapter.

Gamma Radiation from PSR B1055-52

NASA Technical Reports Server (NTRS)

Thompson, D. J.; Bailes, M.; Bertsch, D. L.; Cordes, J.; DAmico, N.; Esposito, J. A.; Finley, J.; Hartman, R. C.; Hermsen, W.; Kanbach, G.;

The World According to de Finetti: On de Finetti's Theory of Probability and Its Application to Quantum Mechanics

NASA Astrophysics Data System (ADS)

Berkovitz, Joseph

Bruno de Finetti is one of the founding fathers of the subjectivist school of probability, where probabilities are interpreted as rational degrees of belief. His work on the relation between the theorems of probability and rationality is among the corner stones of modern subjective probability theory. De Finetti maintained that rationality requires that degrees of belief be coherent, and he argued that the whole of probability theory could be derived from these coherence conditions. De Finetti's interpretation of probability has been highly influential in science. This paper focuses on the application of this interpretation to quantum mechanics. We argue that de Finetti held that the coherence conditions of degrees of belief in events depend on their verifiability. Accordingly, the standard coherence conditions of degrees of belief that are familiar from the literature on subjective probability only apply to degrees of belief in events which could (in principle) be jointly verified; and the coherence conditions of degrees of belief in events that cannot be jointly verified are weaker. While the most obvious explanation of de Finetti's verificationism is the influence of positivism, we argue that it could be motivated by the radical subjectivist and instrumental nature of probability in his interpretation; for as it turns out, in this interpretation it is difficult to make sense of the idea of coherent degrees of belief in, and accordingly probabilities of unverifiable events. We then consider the application of this interpretation to quantum mechanics, concentrating on the Einstein-Podolsky-Rosen experiment and Bell's theorem.

Practical guidelines for interpreting copy number gains detected by high-resolution array in routine diagnostics

PubMed Central

Hanemaaijer, Nicolien M; Sikkema-Raddatz, Birgit; van der Vries, Gerben; Dijkhuizen, Trijnie; Hordijk, Roel; van Essen, Anthonie J; Veenstra-Knol, Hermine E; Kerstjens-Frederikse, Wilhelmina S; Herkert, Johanna C; Gerkes, Erica H; Leegte, Lamberta K; Kok, Klaas; Sinke, Richard J; van Ravenswaaij-Arts, Conny M A

2012-01-01

The correct interpretation of copy number gains in patients with developmental delay and multiple congenital anomalies is hampered by the large number of copy number variations (CNVs) encountered in healthy individuals. The variable phenotype associated with copy number gains makes interpretation even more difficult. Literature shows that inheritence, size and presence in healthy individuals are commonly used to decide whether a certain copy number gain is pathogenic, but no general consensus has been established. We aimed to develop guidelines for interpreting gains detected by array analysis using array CGH data of 300 patients analysed with the 105K Agilent oligo array in a diagnostic setting. We evaluated the guidelines in a second, independent, cohort of 300 patients. In the first 300 patients 797 gains of four or more adjacent oligonucleotides were observed. Of these, 45.4% were de novo and 54.6% were familial. In total, 94.8% of all de novo gains and 87.1% of all familial gains were concluded to be benign CNVs. Clinically relevant gains ranged from 288 to 7912 kb in size, and were significantly larger than benign gains and gains of unknown clinical relevance (P<0.001). Our study showed that a threshold of 200 kb is acceptable in a clinical setting, whereas heritability does not exclude a pathogenic nature of a gain. Evaluation of the guidelines in the second cohort of 300 patients revealed that the interpretation guidelines were clear, easy to follow and efficient. PMID:21934709

User's manual for LSTSQR-1.

DOT National Transportation Integrated Search

1976-01-01

This manual details the preparation of data for and the interpretation of output from the least squares computer program LSTSQR-1. The material presented here will be somewhat difficult for the non-computer oriented professional to interpret on the f...

Calibrated Peer Review for Interpreting Linear Regression Parameters: Results from a Graduate Course

ERIC Educational Resources Information Center

Enders, Felicity B.; Jenkins, Sarah; Hoverman, Verna

2010-01-01

Biostatistics is traditionally a difficult subject for students to learn. While the mathematical aspects are challenging, it can also be demanding for students to learn the exact language to use to correctly interpret statistical results. In particular, correctly interpreting the parameters from linear regression is both a vital tool and a…

Interpretation of Renal Quality of Life Profile scores in routine clinical practice: an aid to treatment decision-making.

PubMed

Aawar, Nadine; Moore, Richard; Riley, Stephen; Salek, Sam

2016-07-01

High Renal Quality of Life Profile (RQLP) scores are associated with impaired health-related quality of life; however, the clinical meaning of the scores is difficult for clinicians and healthcare planners to interpret. The aim of this study was to determine clinical significance of RQLP scores which could be used to aid clinical decision-making. The anchor-based technique (a method for categorizing numeric scores to ease interpretation) was used to develop a categorization system for the RQLP scores using a global question (GQ). The GQ scores (i.e. no effect to extremely large effect) were mapped against the RQLP scores, and intraclass correlation coefficient (ICC) was used to test their agreement. The RQLP and the GQ were administered to 260 adult patients (males = 165 and females = 95) with chronic renal failure (CRF). The mean RQLP score was 67.2, median = 61, SD = 41.5, and range 0-172. The mean GQ score was 1.74, median = 2, SD = 1.27, and range 0-4. The mean, mode, and median of the GQ scores for each RQLP score were used to devise several sets of categories of RQLP score, and the ICC test of agreement was calculated. The proposed set of RQLP score banding for adoption includes: 0-20 = no effect on patient's life (GQ = 0, n = 35); 21-51 = small effect on patient's life (GQ = 1, n = 66); 52-93 = moderate effect on patient's life (GQ = 2, n = 87); 94-134 = very large effect on patient's life (GQ = 3, n = 54); and 135-172 = extremely large effect on patient's life (GQ = 4, n = 18). The ICC coefficient for the proposed banding system was 0.80. The proposed categorization of the RQLP will aid the clinical interpretation of change in RQLP score informing treatment decision-making in routine practice.

Sport medicine and the ethics of boxing.

PubMed

Leclerc, S; Herrera, C D

1999-12-01

In the light of medical evidence of the health risks associated with boxing, a watchful agnostic position among sport physicians is no longer justifiable. The normal activity in a boxing match places the athletes at risk of head injury, some of which may be difficult to detect and impossible to repair. This suggests that sport physicians and others expert in the prevention and diagnosis of such injuries should take a public stand against boxing, as other medical associations have. Although there is a need for continuing research into the health risks, doctors can in the interim take steps to increase public awareness of these risks. Sport physicians in particular can make a strong public statement by also ending their professional involvement with boxing. This need not be interpreted as paternalism; doctors are qualified neither to make laws nor to restrict private behaviour. Sport physicians are, however, well equipped to advise those who do make laws and those who choose to engage in boxing. In the end, because this stance against boxing will probably reduce the number of brain injuries in certain athletes, autonomy will be preserved, rather than restricted.

Analysing data from patient-reported outcome and quality of life endpoints for cancer clinical trials: a start in setting international standards.

PubMed

Bottomley, Andrew; Pe, Madeline; Sloan, Jeff; Basch, Ethan; Bonnetain, Franck; Calvert, Melanie; Campbell, Alicyn; Cleeland, Charles; Cocks, Kim; Collette, Laurence; Dueck, Amylou C; Devlin, Nancy; Flechtner, Hans-Henning; Gotay, Carolyn; Greimel, Eva; Griebsch, Ingolf; Groenvold, Mogens; Hamel, Jean-Francois; King, Madeleine; Kluetz, Paul G; Koller, Michael; Malone, Daniel C; Martinelli, Francesca; Mitchell, Sandra A; Moinpour, Carol M; Musoro, Jammbe; O'Connor, Daniel; Oliver, Kathy; Piault-Louis, Elisabeth; Piccart, Martine; Pimentel, Francisco L; Quinten, Chantal; Reijneveld, Jaap C; Schürmann, Christoph; Smith, Ashley Wilder; Soltys, Katherine M; Taphoorn, Martin J B; Velikova, Galina; Coens, Corneel

2016-11-01

Measures of health-related quality of life (HRQOL) and other patient-reported outcomes generate important data in cancer randomised trials to assist in assessing the risks and benefits of cancer therapies and fostering patient-centred cancer care. However, the various ways these measures are analysed and interpreted make it difficult to compare results across trials, and hinders the application of research findings to inform publications, product labelling, clinical guidelines, and health policy. To address these problems, the Setting International Standards in Analyzing Patient-Reported Outcomes and Quality of Life Endpoints Data (SISAQOL) initiative has been established. This consortium, directed by the European Organisation for Research and Treatment of Cancer (EORTC), was convened to provide recommendations on how to standardise the analysis of HRQOL and other patient-reported outcomes data in cancer randomised trials. This Personal View discusses the reasons why this project was initiated, the rationale for the planned work, and the expected benefits to cancer research, patient and provider decision making, care delivery, and policy making. Copyright © 2016 Elsevier Ltd. All rights reserved.

Foundations of Formative Assessment: Introducing a Learning Progression to Guide Preservice Physics Teachers' Video-Based Interpretation of Student Thinking

ERIC Educational Resources Information Center

von Aufschnaiter, Claudia; Alonzo, Alicia C.

2018-01-01

Establishing nuanced interpretations of student thinking is central to formative assessment but difficult, especially for preservice teachers. Learning progressions (LPs) have been proposed as a framework for promoting interpretations of students' thinking; however, research is needed to investigate whether and how an LP can be used to support…

A streaming birefringence study of the flow at the junction of the aorta and the renal arteries

NASA Astrophysics Data System (ADS)

Rankin, G. W.; Sabbah, H. N.; Stein, P. D.

1989-11-01

Streaming birefringence with an organic dye (Milling Yellow) was used to investigate the flow near the junction of the renal arteries and the descending aorta in a model of human vessels. The dye concentration was adjusted to give fluid rheological properties, typical of blood. Steady and pulsatile flow were investigated at branch-to-trunk flow ratios of 0.050 0.350. The flow ratio range over which flow separation and simple secondary flows were identified during systole near the renal ostia are reported. Streaming birefringence has the advantage of allowing visualization of the entire flow field. Also, the fluid rather than suspended particles are observed. An important disadvantage, however, is that three-dimensional flows make interpretation difficult.

A review of pipe and bamboo artificial refugia as sampling tools in anuran studies

USGS Publications Warehouse

Glorioso, Brad M.; Waddle, J. Hardin

2014-01-01

Artificial pipe-like refugia have been used for more than 40 years in anuran studies, and have captured 28 species, primarily (82%) hylid treefrogs. Early pipe-like refugia were made using cut pieces of bamboo in the tropical forests of Puerto Rico, but most recent studies have used synthetic pipes and have occurred primarily in the southeastern United States. Characteristics of artificial refugia (e.g., color, length, and diameter), and their placement in the environment have varied greatly among studies, making comparisons difficult. Here, we summarize and evaluate different pipe designs and placement, address potential concerns when using artificial pipe-like refugia, and suggest studies necessary to better interpret the data gained from this technique in anuran studies.

ECG Signal Analysis and Arrhythmia Detection using Wavelet Transform

NASA Astrophysics Data System (ADS)

Kaur, Inderbir; Rajni, Rajni; Marwaha, Anupma

2016-12-01

Electrocardiogram (ECG) is used to record the electrical activity of the heart. The ECG signal being non-stationary in nature, makes the analysis and interpretation of the signal very difficult. Hence accurate analysis of ECG signal with a powerful tool like discrete wavelet transform (DWT) becomes imperative. In this paper, ECG signal is denoised to remove the artifacts and analyzed using Wavelet Transform to detect the QRS complex and arrhythmia. This work is implemented in MATLAB software for MIT/BIH Arrhythmia database and yields the sensitivity of 99.85 %, positive predictivity of 99.92 % and detection error rate of 0.221 % with wavelet transform. It is also inferred that DWT outperforms principle component analysis technique in detection of ECG signal.

Characterization of Escherichia coli isolates from different fecal sources by means of classification tree analysis of fatty acid methyl ester (FAME) profiles.

PubMed

Seurinck, Sylvie; Deschepper, Ellen; Deboch, Bishaw; Verstraete, Willy; Siciliano, Steven

2006-03-01

Microbial source tracking (MST) methods need to be rapid, inexpensive and accurate. Unfortunately, many MST methods provide a wealth of information that is difficult to interpret by the regulators who use this information to make decisions. This paper describes the use of classification tree analysis to interpret the results of a MST method based on fatty acid methyl ester (FAME) profiles of Escherichia coli isolates, and to present results in a format readily interpretable by water quality managers. Raw sewage E. coli isolates and animal E. coli isolates from cow, dog, gull, and horse were isolated and their FAME profiles collected. Correct classification rates determined with leaveone-out cross-validation resulted in an overall low correct classification rate of 61%. A higher overall correct classification rate of 85% was obtained when the animal isolates were pooled together and compared to the raw sewage isolates. Bootstrap aggregation or adaptive resampling and combining of the FAME profile data increased correct classification rates substantially. Other MST methods may be better suited to differentiate between different fecal sources but classification tree analysis has enabled us to distinguish raw sewage from animal E. coli isolates, which previously had not been possible with other multivariate methods such as principal component analysis and cluster analysis.

Twenty-first century approaches to toxicity testing, biomonitoring, and risk assessment: perspectives from the global chemical industry.

PubMed

Phillips, Richard D; Bahadori, Tina; Barry, Brenda E; Bus, James S; Gant, Timothy W; Mostowy, Janet M; Smith, Claudia; Willuhn, Marc; Zimmer, Ulrike

2009-09-01

The International Council of Chemical Associations' Long-Range Research Initiative (ICCA-LRI) sponsored a workshop, titled Twenty-First Century Approaches to Toxicity Testing, Biomonitoring, and Risk Assessment, on 16 and 17 June 2008 in Amsterdam, The Netherlands. The workshop focused on interpretation of data from the new technologies for toxicity testing and biomonitoring, and on understanding the relevance of the new data for assessment of human health risks. Workshop participants articulated their concerns that scientific approaches for interpreting and understanding the emerging data in a biologically relevant context lag behind the rapid advancements in the new technologies. Research will be needed to mitigate these lags and to develop approaches for communicating the information, even in a context of uncertainty. A collaborative, coordinated, and sustained research effort is necessary to modernize risk assessment and to significantly reduce current reliance on animal testing. In essence, this workshop was a call to action to bring together the intellectual and financial resources necessary to harness the potential of these new technologies towards improved public health decision making. Without investment in the science of interpretation, it will be difficult to realize the potential that the advanced technologies offer to modernize toxicity testing, exposure science, and risk assessment.

Ediacaran developmental biology

PubMed Central

Liu, Alexander G.; Donoghue, Philip C. J.

2017-01-01

ABSTRACT Rocks of the Ediacaran System (635–541 Ma) preserve fossil evidence of some of the earliest complex macroscopic organisms, many of which have been interpreted as animals. However, the unusual morphologies of some of these organisms have made it difficult to resolve their biological relationships to modern metazoan groups. Alternative competing phylogenetic interpretations have been proposed for Ediacaran taxa, including algae, fungi, lichens, rhizoid protists, and even an extinct higher‐order group (Vendobionta). If a metazoan affinity can be demonstrated for these organisms, as advocated by many researchers, they could prove informative in debates concerning the evolution of the metazoan body axis, the making and breaking of axial symmetries, and the appearance of a metameric body plan. Attempts to decipher members of the enigmatic Ediacaran macrobiota have largely involved study of morphology: comparative analysis of their developmental phases has received little attention. Here we present what is known of ontogeny across the three iconic Ediacaran taxa Charnia masoni, Dickinsonia costata and Pteridinium simplex, together with new ontogenetic data and insights. We use these data and interpretations to re‐evaluate the phylogenetic position of the broader Ediacaran morphogroups to which these taxa are considered to belong (rangeomorphs, dickinsoniomorphs and erniettomorphs). We conclude, based on the available evidence, that the affinities of the rangeomorphs and the dickinsoniomorphs lie within Metazoa. PMID:29105292

Deep learning for single-molecule science

NASA Astrophysics Data System (ADS)

Albrecht, Tim; Slabaugh, Gregory; Alonso, Eduardo; Al-Arif, SM Masudur R.

2017-10-01

Exploring and making predictions based on single-molecule data can be challenging, not only due to the sheer size of the datasets, but also because a priori knowledge about the signal characteristics is typically limited and poor signal-to-noise ratio. For example, hypothesis-driven data exploration, informed by an expectation of the signal characteristics, can lead to interpretation bias or loss of information. Equally, even when the different data categories are known, e.g., the four bases in DNA sequencing, it is often difficult to know how to make best use of the available information content. The latest developments in machine learning (ML), so-called deep learning (DL) offer interesting, new avenues to address such challenges. In some applications, such as speech and image recognition, DL has been able to outperform conventional ML strategies and even human performance. However, to date DL has not been applied much in single-molecule science, presumably in part because relatively little is known about the ‘internal workings’ of such DL tools within single-molecule science as a field. In this Tutorial, we make an attempt to illustrate in a step-by-step guide how one of those, a convolutional neural network (CNN), may be used for base calling in DNA sequencing applications. We compare it with a SVM as a more conventional ML method, and discuss some of the strengths and weaknesses of the approach. In particular, a ‘deep’ neural network has many features of a ‘black box’, which has important implications on how we look at and interpret data.

Moving from the laboratory to the field: Adding natural environmental conditions to toxicology testing

EPA Science Inventory

While laboratory toxicology tests are generally easy to perform, cost effective and readily interpreted, they have been criticized for being unrealistic. In contrast, field tests are considered realistic while producing results that are difficult to interpret and expensive. To ...

Identifying climate risk perceptions, information needs, and barriers to information exchange among public land managers.

PubMed

Peters, Casey B; Schwartz, Mark W; Lubell, Mark N

2018-03-01

Meeting ecosystem management challenges posed by climate change requires building effective communication channels among researchers, planners and practitioners to focus research on management issues requiring new knowledge. We surveyed resource managers within two regions of the western United States regions to better understand perceived risks and vulnerabilities associated with climate change and barriers to obtaining and using relevant climate science information in making ecosystem management decisions. We sought to understand what types of climate science information resource managers find most valuable, and the formats in which they prefer to receive climate science information. We found broad concern among natural resource managers in federal agencies that climate change will make it more difficult for them to achieve their management goals. Primary barriers to incorporating climate science into planning are distributed among challenges identifying, receiving, and interpreting appropriate science and a lack of direction provided by agency leadership needed to meaningfully use this emerging science in resource planning. Copyright © 2017 Elsevier B.V. All rights reserved.

More of an art than a science: Using microbial DNA sequences to compose music

DOE PAGES

Larsen, Peter E.

2016-03-01

Bacteria are everywhere. Microbial ecology is emerging as a critical field for understanding the relationships between these ubiquitous bacterial communities, the environment, and human health. Next generation DNA sequencing technology provides us a powerful tool to indirectly observe the communities by sequencing and analyzing all of the bacterial DNA present in an environment. The results of the DNA sequencing experiments can generate gigabytes to terabytes of information however, making it difficult for the citizen scientist to grasp and the educator to convey this data. Here, we present a method for interpreting massive amounts of microbial ecology data as musical performances,more » easily generated on any computer and using only commonly available or freely available software and the ‘Microbial Bebop’ algorithm. Furthermore, using this approach citizen scientists and biology educators can sonify complex data in a fun and interactive format, making it easier to communicate both the importance and the excitement of exploring the planet earth’s largest ecosystem.« less

Creating value in health by understanding and overcoming resistance to de-innovation.

PubMed

Ubel, Peter A; Asch, David A

2015-02-01

As hard as it may be for clinicians to adopt new practices, it is often harder for them to "de-innovate," or give up old practices, even when new evidence reveals that those practices offer little value. In this article we explore recent controversies over screening for breast and prostate cancer and testing for sleep disorders. We show that these controversies are not caused solely by a lack of clinical data on the harms and benefits of these tests but are also influenced by several psychological biases that make it difficult for clinicians to de-innovate. De-innovation could be fostered by making sure that advisory panels and guideline committees include experts who have competing biases; emphasizing evidence over clinical judgment; resisting "indication creep," or the premature extension of innovations into unproven areas; and encouraging clinicians to explicitly consider how their experiences bias their interpretations of clinical evidence. Project HOPE—The People-to-People Health Foundation, Inc.

More of an art than a science: Using microbial DNA sequences to compose music

DOE Office of Scientific and Technical Information (OSTI.GOV)

Larsen, Peter E.

Bacteria are everywhere. Microbial ecology is emerging as a critical field for understanding the relationships between these ubiquitous bacterial communities, the environment, and human health. Next generation DNA sequencing technology provides us a powerful tool to indirectly observe the communities by sequencing and analyzing all of the bacterial DNA present in an environment. The results of the DNA sequencing experiments can generate gigabytes to terabytes of information however, making it difficult for the citizen scientist to grasp and the educator to convey this data. Here, we present a method for interpreting massive amounts of microbial ecology data as musical performances,more » easily generated on any computer and using only commonly available or freely available software and the ‘Microbial Bebop’ algorithm. Furthermore, using this approach citizen scientists and biology educators can sonify complex data in a fun and interactive format, making it easier to communicate both the importance and the excitement of exploring the planet earth’s largest ecosystem.« less

Follow-Up Research on Agoraphobics.

ERIC Educational Resources Information Center

Chambless, Dianne L.

In vivo exposure is the most commonly used and generally the most effective behavioral treatment for agoraphobia. Follow-up studies are difficult to interpret because additional treatment does not necessarily indicate relapse and non-treatment does not necessarily indicate non-relapse. Relapse rates are difficult to estimate because of lack of…

Effective Compiler Error Message Enhancement for Novice Programming Students

ERIC Educational Resources Information Center

Becker, Brett A.; Glanville, Graham; Iwashima, Ricardo; McDonnell, Claire; Goslin, Kyle; Mooney, Catherine

2016-01-01

Programming is an essential skill that many computing students are expected to master. However, programming can be difficult to learn. Successfully interpreting compiler error messages (CEMs) is crucial for correcting errors and progressing toward success in programming. Yet these messages are often difficult to understand and pose a barrier to…

Including values in evidence-based policy making for breast screening: An empirically grounded tool to assist expert decision makers.

PubMed

Parker, Lisa

2017-07-01

Values are an important part of evidence-based decision making for health policy: they guide the type of evidence that is collected, how it is interpreted, and how important the conclusions are considered to be. Experts in breast screening (including clinicians, researchers, consumer advocates and senior administrators) hold differing values in relation to what is important in breast screening policy and practice, and committees may find it difficult to incorporate the complexity and variety of values into policy decisions. The decision making tool provided here is intended to assist with this process. The tool is modified from more general frameworks that are intended to assist with ethical decision making in public health, and informed by data drawn from previous empirical studies on values amongst Australian breast screening experts. It provides a structured format for breast screening committees to consider and discuss the values of themselves and others, suggests relevant topics for further inquiry and highlights areas of need for future research into the values of the public. It enables committees to publicly explain and justify their decisions with reference to values, improving transparency and accountability. It is intended to act alongside practices that seek to accommodate the values of individual women in the informed decision making process for personal decision making about participation in breast screening. Copyright © 2017 Elsevier B.V. All rights reserved.

Learning lessons from field surveys in humanitarian contexts: a case study of field surveys conducted in North Kivu, DRC 2006-2008

PubMed Central

Grais, Rebecca F; Luquero, Francisco J; Grellety, Emmanuel; Pham, Heloise; Coghlan, Benjamin; Salignon, Pierre

2009-01-01

Survey estimates of mortality and malnutrition are commonly used to guide humanitarian decision-making. Currently, different methods of conducting field surveys are the subject of debate among epidemiologists. Beyond the technical arguments, decision makers may find it difficult to conceptualize what the estimates actually mean. For instance, what makes this particular situation an emergency? And how should the operational response be adapted accordingly. This brings into question not only the quality of the survey methodology, but also the difficulties epidemiologists face in interpreting results and selecting the most important information to guide operations. As a case study, we reviewed mortality and nutritional surveys conducted in North Kivu, Democratic Republic of Congo (DRC) published from January 2006 to January 2009. We performed a PubMed/Medline search for published articles and scanned publicly available humanitarian databases and clearinghouses for grey literature. To evaluate the surveys, we developed minimum reporting criteria based on available guidelines and selected peer-review articles. We identified 38 reports through our search strategy; three surveys met our inclusion criteria. The surveys varied in methodological quality. Reporting against minimum criteria was generally good, but presentation of ethical procedures, raw data and survey limitations were missed in all surveys. All surveys also failed to consider contextual factors important for data interpretation. From this review, we conclude that mechanisms to ensure sound survey design and conduct must be implemented by operational organisations to improve data quality and reporting. Training in data interpretation would also be useful. Novel survey methods should be trialled and prospective data gathering (surveillance) employed wherever feasible. PMID:19744319

Interpreting semantic clustering effects in free recall.

PubMed

Manning, Jeremy R; Kahana, Michael J

2012-07-01

The order in which participants choose to recall words from a studied list of randomly selected words provides insights into how memories of the words are represented, organised, and retrieved. One pervasive finding is that when a pair of semantically related words (e.g., "cat" and "dog") is embedded in the studied list, the related words are often recalled successively. This tendency to successively recall semantically related words is termed semantic clustering (Bousfield, 1953; Bousfield & Sedgewick, 1944; Cofer, Bruce, & Reicher, 1966). Measuring semantic clustering effects requires making assumptions about which words participants consider to be similar in meaning. However, it is often difficult to gain insights into individual participants' internal semantic models, and for this reason researchers typically rely on standardised semantic similarity metrics. Here we use simulations to gain insights into the expected magnitudes of semantic clustering effects given systematic differences between participants' internal similarity models and the similarity metric used to quantify the degree of semantic clustering. Our results provide a number of useful insights into the interpretation of semantic clustering effects in free recall.

Consumer subjectivity and U.S. health care reform.

PubMed

West, Emily

2014-01-01

Health care consumerism is an important frame in U.S. health care policy, especially in recent media and policy discourse about federal health care reform. This article reports on qualitative fieldwork with health care users to find out how people interpret and make sense of the identity of "health care consumer." It proposes that while the term consumer is normally understood as a descriptive label for users who purchase health care and insurance services, it should actually be understood as a metaphor, carrying with it a host of associations that shape U.S. health care policy debates in particular ways. Based on interviews with 36 people, patient was the dominant term people used to describe themselves, but consumer was the second most popular. Informants interpreted the health care consumer as being informed, proactive, and having choices, but there were also "semiotic traps," or difficult-to-resolve tensions for this identity. The discourse of consumerism functions in part as code for individual responsibility, and therefore as a classed moral discourse, with implications for U.S. health care policy.

Dynamic calibration and analysis of crack tip propagation in energetic materials using real-time radiography

NASA Astrophysics Data System (ADS)

Butt, Ali

Crack propagation in a solid rocket motor environment is difficult to measure directly. This experimental and analytical study evaluated the viability of real-time radiography for detecting bore regression and propellant crack propagation speed. The scope included the quantitative interpretation of crack tip velocity from simulated radiographic images of a burning, center-perforated grain and actual real-time radiographs taken on a rapid-prototyped model that dynamically produced the surface movements modeled in the simulation. The simplified motor simulation portrayed a bore crack that propagated radially at a speed that was 10 times the burning rate of the bore. Comparing the experimental image interpretation with the calibrated surface inputs, measurement accuracies were quantified. The average measurements of the bore radius were within 3% of the calibrated values with a maximum error of 7%. The crack tip speed could be characterized with image processing algorithms, but not with the dynamic calibration data. The laboratory data revealed that noise in the transmitted X-Ray intensity makes sensing the crack tip propagation using changes in the centerline transmitted intensity level impractical using the algorithms employed.

The translational metaphor in psychoanalysis.

PubMed

Kirshner, Lewis

2015-02-01

The translational metaphor in psychoanalysis refers to the traditional method of interpreting or restating the meaning of verbal and behavioral acts of a patient in other, presumably more accurate terms that specify the forces and conflicts underlying symptoms. The analyst translates the clinical phenomenology to explain its true meaning and origin. This model of analytic process has been challenged from different vantage points by authors presenting alternative conceptions of therapeutic action. Although the temptation to find and make interpretations of clinical material is difficult to resist, behaving in this way places the analyst in the position of a teacher or diagnostician, seeking a specific etiology, which has not proven fruitful. Despite its historical appeal, I argue that the translational model is a misleading and anachronistic version of what actually occurs in psychoanalysis. I emphasize instead the capacity of analysis to promote the emergence of new forms of representation, or figuration, from the unconscious, using the work of Lacan, Laplanche, and Modell to exemplify this reformulation, and provide clinical illustrations of how it looks in practice. Copyright © 2014 Institute of Psychoanalysis.

Influence of make-up on facial recognition.

PubMed

Ueda, Sayako; Koyama, Takamasa

2010-01-01

Make-up may enhance or disguise facial characteristics. The influence of wearing make-up on facial recognition could be of two kinds: (i) when women do not wear make-up and then are seen with make-up, and (ii) when women wear make-up and then are seen without make-up. A study is reported which shows that light make-up makes it easier to recognise a face, and heavy make-up makes it more difficult. Seeing initially a made-up face makes any subsequent facial recognition more difficult than initially seeing that face without make-up.

Risk perception & strategic decision making :general insights, a framework, and specific application to electricity generation using nuclear energy.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brewer, Jeffrey D.

The objective of this report is to promote increased understanding of decision making processes and hopefully to enable improved decision making regarding high-consequence, highly sophisticated technological systems. This report brings together insights regarding risk perception and decision making across domains ranging from nuclear power technology safety, cognitive psychology, economics, science education, public policy, and neural science (to name a few). It forms them into a unique, coherent, concise framework, and list of strategies to aid in decision making. It is suggested that all decision makers, whether ordinary citizens, academics, or political leaders, ought to cultivate their abilities to separate themore » wheat from the chaff in these types of decision making instances. The wheat includes proper data sources and helpful human decision making heuristics; these should be sought. The chaff includes ''unhelpful biases'' that hinder proper interpretation of available data and lead people unwittingly toward inappropriate decision making ''strategies''; obviously, these should be avoided. It is further proposed that successfully accomplishing the wheat vs. chaff separation is very difficult, yet tenable. This report hopes to expose and facilitate navigation away from decision-making traps which often ensnare the unwary. Furthermore, it is emphasized that one's personal decision making biases can be examined, and tools can be provided allowing better means to generate, evaluate, and select among decision options. Many examples in this report are tailored to the energy domain (esp. nuclear power for electricity generation). The decision making framework and approach presented here are applicable to any high-consequence, highly sophisticated technological system.« less

Linguistic and pragmatic constraints on utterance interpretation

NASA Astrophysics Data System (ADS)

Hinkelman, Elizabeth A.

1990-05-01

In order to model how people understand language, it is necessary to understand not only grammar and logic but also how people use language to affect their environment. This area of study is known as natural language pragmatics. Speech acts, for instance, are the offers, promises, announcements, etc., that people make by talking. The same expression may be different acts in different contexts, and yet not every expression performs every act. We want to understand how people are able to recognize other's intentions and implications in saying something. Previous plan-based theories of speech act interpretation do not account for the conventional aspect of speech acts. They can, however, be made sensitive to both linguistic and propositional information. This dissertation presents a method of speech act interpretation which uses patterns of linguistic features (e.g., mood, verb form, sentence adverbials, thematic roles) to identify a range of speech act interpretations for the utterance. These are then filtered and elaborated by inferences about agents' goals and plans. In many cases the plan reasoning consists of short, local inference chains (that are in fact conversational implicatures) and, extended reasoning is necessary only for the most difficult cases. The method is able to accommodate a wide range of cases, from those which seem very idiomatic to those which must be analyzed using knowledge about the world and human behavior. It explains how, Can you pass the salt, can be a request while, Are you able to pass the salt, is not.

Statistical Hypothesis Testing in Intraspecific Phylogeography: NCPA versus ABC

PubMed Central

Templeton, Alan R.

2009-01-01

Nested clade phylogeographic analysis (NCPA) and approximate Bayesian computation (ABC) have been used to test phylogeographic hypotheses. Multilocus NCPA tests null hypotheses, whereas ABC discriminates among a finite set of alternatives. The interpretive criteria of NCPA are explicit and allow complex models to be built from simple components. The interpretive criteria of ABC are ad hoc and require the specification of a complete phylogeographic model. The conclusions from ABC are often influenced by implicit assumptions arising from the many parameters needed to specify a complex model. These complex models confound many assumptions so that biological interpretations are difficult. Sampling error is accounted for in NCPA, but ABC ignores important sources of sampling error that creates pseudo-statistical power. NCPA generates the full sampling distribution of its statistics, but ABC only yields local probabilities, which in turn make it impossible to distinguish between a good fitting model, a non-informative model, and an over-determined model. Both NCPA and ABC use approximations, but convergences of the approximations used in NCPA are well defined whereas those in ABC are not. NCPA can analyze a large number of locations, but ABC cannot. Finally, the dimensionality of tested hypothesis is known in NCPA, but not for ABC. As a consequence, the “probabilities” generated by ABC are not true probabilities and are statistically non-interpretable. Accordingly, ABC should not be used for hypothesis testing, but simulation approaches are valuable when used in conjunction with NCPA or other methods that do not rely on highly parameterized models. PMID:19192182

Working with Child Prostitutes in Thailand: Problems of Practice and Interpretation

ERIC Educational Resources Information Center

Montgomery, Heather

2007-01-01

Conducting anthropological fieldwork on the emotive issue of child prostitution raises difficult issues for anthropologists and other researchers. This article examines the ethical dilemmas of working with these extremely vulnerable children, focusing on the difference between the researcher's own interpretations and those given by the children…

Effects of low levels of herbicides on potatoes, soybeans and peas grown in a greenhouse and outside

EPA Science Inventory

While laboratory toxicology tests are generally easy to perform, cost effective and readily interpreted, they have been questioned for their environmental relevance. In contrast, field tests are considered realistic while producing results that are difficult to interpret and exp...

Applying the Bootstrap to Taxometric Analysis: Generating Empirical Sampling Distributions to Help Interpret Results

ERIC Educational Resources Information Center

Ruscio, John; Ruscio, Ayelet Meron; Meron, Mati

2007-01-01

Meehl's taxometric method was developed to distinguish categorical and continuous constructs. However, taxometric output can be difficult to interpret because expected results for realistic data conditions and differing procedural implementations have not been derived analytically or studied through rigorous simulations. By applying bootstrap…

Recognising and responding to suicidal crisis within family and social networks: qualitative study.

PubMed

Owens, Christabel; Owen, Gareth; Belam, Judith; Lloyd, Keith; Rapport, Frances; Donovan, Jenny; Lambert, Helen

2011-10-18

To shed light on the difficulties faced by relatives, friends, and colleagues in interpreting signs of suicidality and deciding whether and how to intervene. Qualitative study of completed suicides, based on in-depth interviews with multiple informants. London, southwest England, and south Wales. 31 lay informants (one to five for each case), including parents, partners, siblings, friends, and colleagues of 14 cases of suicide in which the deceased was aged 18-34 and was not in contact with secondary mental health services. Informants described both intellectual and emotional barriers to awareness and intervention within the family and social network. They reported that signs and communications of distress were often oblique and difficult to interpret, that they may have disregarded warning signals and focused instead on positive signs, and that, even when they were aware that something was seriously wrong, taking any action at all involved considerable personal risks. As the suicidal process unfolds, significant others are faced with a highly complex task. Their proximity to the suicidal person and their emotional investment in the relationship make it difficult for them to see what is happening, to say anything to the person or to other members of the network, or to seek help outside the network. Efforts to strengthen the capacity of lay people to play a role in preventing suicide are urgently needed and should be informed by a thorough understanding of these difficulties. They should highlight the ambiguous nature of warning signs and should focus on helping people to acknowledge and overcome their fears about intervening.

An assessment of thin cloud detection by applying bidirectional reflectance distribution function model-based background surface reflectance using Geostationary Ocean Color Imager (GOCI): A case study for South Korea

NASA Astrophysics Data System (ADS)

Kim, Hye-Won; Yeom, Jong-Min; Shin, Daegeun; Choi, Sungwon; Han, Kyung-Soo; Roujean, Jean-Louis

2017-08-01

In this study, a new assessment of thin cloud detection with the application of bidirectional reflectance distribution function (BRDF) model-based background surface reflectance was undertaken by interpreting surface spectra characterized using the Geostationary Ocean Color Imager (GOCI) over a land surface area. Unlike cloud detection over the ocean, the detection of cloud over land surfaces is difficult due to the complicated surface scattering characteristics, which vary among land surface types. Furthermore, in the case of thin clouds, in which the surface and cloud radiation are mixed, it is difficult to detect the clouds in both land and atmospheric fields. Therefore, to interpret background surface reflectance, especially underneath cloud, the semiempirical BRDF model was used to simulate surface reflectance by reflecting solar angle-dependent geostationary sensor geometry. For quantitative validation, Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO) data were used to make a comparison with the proposed cloud masking result. As a result, the new cloud masking scheme resulted in a high probability of detection (POD = 0.82) compared with the Moderate Resolution Imaging Spectroradiometer (MODIS) (POD = 0.808) for all cloud cases. In particular, the agreement between the CALIPSO cloud product and new GOCI cloud mask was over 94% when detecting thin cloud (e.g., altostratus and cirrus) from January 2014 to June 2015. This result is relatively high in comparison with the result from the MODIS Collection 6 cloud mask product (MYD35).

Classification and regression tree analysis vs. multivariable linear and logistic regression methods as statistical tools for studying haemophilia.

PubMed

Henrard, S; Speybroeck, N; Hermans, C

2015-11-01

Haemophilia is a rare genetic haemorrhagic disease characterized by partial or complete deficiency of coagulation factor VIII, for haemophilia A, or IX, for haemophilia B. As in any other medical research domain, the field of haemophilia research is increasingly concerned with finding factors associated with binary or continuous outcomes through multivariable models. Traditional models include multiple logistic regressions, for binary outcomes, and multiple linear regressions for continuous outcomes. Yet these regression models are at times difficult to implement, especially for non-statisticians, and can be difficult to interpret. The present paper sought to didactically explain how, why, and when to use classification and regression tree (CART) analysis for haemophilia research. The CART method is non-parametric and non-linear, based on the repeated partitioning of a sample into subgroups based on a certain criterion. Breiman developed this method in 1984. Classification trees (CTs) are used to analyse categorical outcomes and regression trees (RTs) to analyse continuous ones. The CART methodology has become increasingly popular in the medical field, yet only a few examples of studies using this methodology specifically in haemophilia have to date been published. Two examples using CART analysis and previously published in this field are didactically explained in details. There is increasing interest in using CART analysis in the health domain, primarily due to its ease of implementation, use, and interpretation, thus facilitating medical decision-making. This method should be promoted for analysing continuous or categorical outcomes in haemophilia, when applicable. © 2015 John Wiley & Sons Ltd.

The use (or misuse) of microsatellite allelic distances in the context of inbreeding and conservation genetics.

PubMed

Hansson, Bengt

2010-03-01

In line with inbreeding theory, genetic diversity at a set of molecular markers may explain variation in fitness-associated traits in partially inbred populations, and such associations will appear as 'genotype-fitness correlations'. An individual genetic diversity index specifically used for microsatellites is 'mean d(2)', i.e. the mean squared distance between alleles. The original hypothesis for mean d(2)-fitness correlations assumes that mean d(2) captures fitness effects at both ends of the inbreeding-outbreeding spectrum. This hypothesis received strong criticism from work showing that even a plain diversity estimate such as multi-locus heterozygosity (MLH) outperforms mean d(2) as a predictor of the inbreeding coefficient and fitness in most realistic situations. Despite this critique, the mean d(2)-approach is still used frequently in ecological and evolutionary research, producing results suggesting that mean d(2) sometimes provides a stronger prediction of fitness than does MLH. In light of the critique, such results are unexpected, but potential explanations for them may exist (at least hypothetically), including scenarios based on close linkage and recent admixture. Nevertheless, a major caveat is that it is very difficult to predict a priori if mean d(2) will improve the genotype-fitness correlation, which in turn makes objective interpretations difficult. Mean d(2)-fitness associations are potentially interesting, but the fact that we cannot easily understand them is problematic and should be thoroughly addressed in each study. Therefore, instead of hastily reached interpretations of mean d(2)-fitness correlations, conclusions need support from complementary analyses, e.g. verifying admixture of genetically structured populations.

Public participation and environmental impact assessment: Purposes, implications, and lessons for public policy making

DOE Office of Scientific and Technical Information (OSTI.GOV)

O'Faircheallaigh, Ciaran, E-mail: Ciaran.Ofaircheallaigh@griffith.edu.a

In recent years the need to enhance public participation in Environmental Impact Assessment (EIA), and the efficacy of alternative mechanisms in achieving this goal, have been central themes in the EIA literature. The benefits of public participation are often taken for granted, and partly for this reason the underlying rationale for greater public participation is sometimes poorly articulated, making it more difficult to determine how to pursue it effectively. The reasons for seeking public participation are also highly diverse and not always mutually consistent. There has been limited analysis of the implications of different forms and degrees of public participationmore » for public decision making based on EIA, and little discussion of how experience with public participation in EIA relates to debates about participation in policy making generally. This paper distinguishes various purposes for public participation in EIA, and discusses their implications for decision making. It then draws on some general models of public participation in policy making to consider how approaches to participation in EIA can be interpreted and valued, and asks what EIA experience reveals about the utility of these models. It argues that the models pay insufficient attention to the interaction that can occur between different forms of public participation; and to the fact that public participation raises issues regarding control over decision making that are not subject to resolution, but must be managed through ongoing processes of negotiation.« less

[Lymphoscintigrams with anatomical landmarks obtained with vector graphics].

PubMed

Rubini, Giuseppe; Antonica, Filippo; Renna, Maria Antonia; Ferrari, Cristina; Iuele, Francesca; Stabile Ianora, Antonio Amato; Losco, Matteo; Niccoli Asabella, Artor

2012-11-01

Nuclear medicine images are difficult to interpret because they do not include anatomical details. The aim of this study was to obtain lymphoscintigrams with anatomical landmarks that could be easily interpreted by General Physicians. Traditional lymphoscintigrams were processed with Adobe© Photoshop® CS6 and converted into vector images created by Illustrator®. The combination with a silhouette vector improved image interpretation, without resulting in longer radiation exposure or acquisition times.

Time-frequency analysis of GPR data to investigate the damage of monumental buildings

NASA Astrophysics Data System (ADS)

Leucci, Giovanni; Masini, Nicola; Persico, Raffaele

2012-08-01

The presence of particular microclimatic conditions inside monumental buildings is responsible for bio-deterioration processes. In many cases, efflorescence and moulds are visible on the facades of several monuments of historical importance. In many other cases, the effects of decay processes are not visible, thus making difficult the diagnosis and the consequent setup of effective rehabilitation and preservation interventions, especially in the presence of a complex geometry and/or a large variability of construction materials. In such cases, a valuable contribution could be provided by geophysical methods (such as electrical resistivity, electromagnetic conductivity, ground-penetrating radar (GPR), etc), which have been proved to be successful tools for sub-surface investigation and characterization of historical buildings. In old monumental buildings, the masonry structures frequently exhibit cracks, voids, detachments and high moisture contrasts that can give rise to reflection events in radar signals. However, the complexity of the geometry and the structural heterogeneity that characterize these old structures often make the GPR results difficult to analyse and interpret. In particular, the spatial variation in GPR signal attenuation can provide important information about the electrical properties of the investigated materials that, in turn, can be used to assess the physical parameters associated with damage. In this paper, we propose an approach that analyses the data in the form of ‘frequency maps’ to evidence absorption losses probably linked to higher moisture content. Two real case histories back up the proposed method.

[Medical expert systems and clinical needs].

PubMed

Buscher, H P

1991-10-18

The rapid expansion of computer-based systems for problem solving or decision making in medicine, the so-called medical expert systems, emphasize the need for reappraisal of their indication and value. Where specialist knowledge is required, in particular where medical decisions are susceptible to error these systems will probably serve as a valuable support. In the near future computer-based systems should be able to aid the interpretation of findings of technical investigations and the control of treatment, especially where rapid reactions are necessary despite the need of complex analysis of investigated parameters. In the distant future complete support of diagnostic procedures from the history to final diagnosis is possible. It promises to be particularly attractive for the diagnosis of seldom diseases, for difficult differential diagnoses, and in the decision making in the case of expensive, risky or new diagnostic or therapeutic methods. The physician needs to be aware of certain dangers, ranging from misleading information up to abuse. Patient information depends often on subjective reports and error-prone observations. Although basing on problematic knowledge computer-born decisions may have an imperative effect on medical decision making. Also it must be born in mind that medical decisions should always combine the rational with a consideration of human motives.

Sport medicine and the ethics of boxing

PubMed Central

Leclerc, S.; Herrera, C. D.

1999-01-01

In the light of medical evidence of the health risks associated with boxing, a watchful agnostic position among sport physicians is no longer justifiable. The normal activity in a boxing match places the athletes at risk of head injury, some of which may be difficult to detect and impossible to repair. This suggests that sport physicians and others expert in the prevention and diagnosis of such injuries should take a public stand against boxing, as other medical associations have. Although there is a need for continuing research into the health risks, doctors can in the interim take steps to increase public awareness of these risks. Sport physicians in particular can make a strong public statement by also ending their professional involvement with boxing. This need not be interpreted as paternalism; doctors are qualified neither to make laws nor to restrict private behaviour. Sport physicians are, however, well equipped to advise those who do make laws and those who choose to engage in boxing. In the end, because this stance against boxing will probably reduce the number of brain injuries in certain athletes, autonomy will be preserved, rather than restricted. 


 PMID:10597855

PubMed Central

Perreault, C

1981-01-01

Human leukocyte antigens (HLA) are transmembrane bicatenar glycoproteins; their heavy chain is coded by chromosome 6 and carries allotypic determinants. These molecules are present in nearly every cell, tissue and biologic fluid. Their congenital absence from fibroblasts is associated with progeria, while their absence from lymphocytes is associated with immunodeficiency. HLA antigens are usually studied microlymphocytotoxicity tests. The numerous cross-reactions encountered make the interpretation of results quite difficult. To clearly understand these reactions a complex-complex model is mandatory. The antigen, the HLA molecule, is complex since it carries many antigenic determinants; some of them are private ("subtypic"), while others are public ("subtypic"). Anti-HLA antibodies are also complex since they are heterogeneous, reacting with variable affinity with different antigenic determinants. The in vitro cross-reactions represent a partial explanation for varying cross-immunogenicity in vivo. PMID:7008927

GOMA: functional enrichment analysis tool based on GO modules

PubMed Central

Huang, Qiang; Wu, Ling-Yun; Wang, Yong; Zhang, Xiang-Sun

2013-01-01

Analyzing the function of gene sets is a critical step in interpreting the results of high-throughput experiments in systems biology. A variety of enrichment analysis tools have been developed in recent years, but most output a long list of significantly enriched terms that are often redundant, making it difficult to extract the most meaningful functions. In this paper, we present GOMA, a novel enrichment analysis method based on the new concept of enriched functional Gene Ontology (GO) modules. With this method, we systematically revealed functional GO modules, i.e., groups of functionally similar GO terms, via an optimization model and then ranked them by enrichment scores. Our new method simplifies enrichment analysis results by reducing redundancy, thereby preventing inconsistent enrichment results among functionally similar terms and providing more biologically meaningful results. PMID:23237213

Understanding the Pathophysiology of Portosystemic Shunt by Simulation Using an Electric Circuit.

PubMed

Kim, Moonhwan; Lee, Keon-Young

2016-01-01

Portosystemic shunt (PSS) without a definable cause is a rare condition, and most of the studies on this topic are small series or based on case reports. Moreover, no firm agreement has been reached on the definition and classification of various forms of PSS, which makes it difficult to compare and analyze the management. The blood flow can be seen very similar to an electric current, governed by Ohm's law. The simulation of PSS using an electric circuit, combined with the interpretation of reported management results, can provide intuitive insights into the underlying mechanism of PSS development. In this article, we have built a model of PSS using electric circuit symbols and explained clinical manifestations as well as the possible mechanisms underlying a PSS formation.

Cautionary tales in the interpretation of observational studies of effects of clinical interventions.

PubMed

Scott, I A; Attia, J

2017-02-01

Observational studies of the effectiveness of clinical interventions are proliferating as more 'real-world' clinical data (so called 'big data') are gathered from clinical registries, administrative datasets and electronic health records. While well-conducted randomised controlled trials (RCT) remain the scientific standard in assessing the efficacy of clinical interventions, well-designed observational studies may add to the evidence base of effectiveness in situations where RCT are of limited value or very difficult to perform. Rather than dismissing observational studies, we need to determine what circumstances may justify doing an observational study and when the study is sufficiently rigorous to be considered reasonably trustworthy. This article proposes criteria by which users of the literature might make such determinations. © 2016 Royal Australasian College of Physicians.

On the density and field sensitivities of dielectronic recombination. [rates in coronal plasmas of late stars and sun

NASA Technical Reports Server (NTRS)

Reisenfeld, Daniel B.; Raymond, John C.; Young, Albert R.; Kohl, John L.

1992-01-01

Dielectronic recombination dominates the recombination rates of most ions in coronal plasmas at their temperatures of peak concentration. Because dielectronic recombination goes by way of high nl doubly excited levels, it is susceptible to collisional excitation and ionization, leading to a decreased rate. On the other hand, theoretical studies show that Stark mixing of the nl levels by a modest electric field enhances the dielectronic recombination rate severalfold. The ionization balance is computed here as as function of density, and it is found that the new results require increased emission measures to match the C IV emission line intensities observed in the sun and in late-type stars. They also make it more difficult to interpret the overall EUV emission line spectrum of the sun.

Population substructure in Cache County, Utah: the Cache County study

PubMed Central

2014-01-01

Background Population stratification is a key concern for genetic association analyses. In addition, extreme homogeneity of ethnic origins of a population can make it difficult to interpret how genetic associations in that population may translate into other populations. Here we have evaluated the genetic substructure of samples from the Cache County study relative to the HapMap Reference populations and data from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Results Our findings show that the Cache County study is similar in ethnic diversity to the self-reported "Whites" in the ADNI sample and less homogenous than the HapMap CEU population. Conclusions We conclude that the Cache County study is genetically representative of the general European American population in the USA and is an appropriate population for conducting broadly applicable genetic studies. PMID:25078123

Redox biotransformation and delivery of anthracycline anticancer antibiotics: How interpretable structure-activity relationships of lethality using electrophilicity and the London formula for dispersion interaction work.

PubMed

Pang, Siu-Kwong

2017-03-30

Quantum chemical methods and molecular mechanics approaches face a lot of challenges in drug metabolism study because of their either insufficient accuracy or huge computational cost, or lack of clear molecular level pictures for building computational models. Low-cost QSAR methods can often be carried out even though molecular level pictures are not well defined; however, they show difficulty in identifying the mechanisms of drug metabolism and delineating the effects of chemical structures on drug toxicity because a certain amount of molecular descriptors are difficult to be interpreted. In order to make a breakthrough, it was proposed that mechanistically interpretable molecular descriptors were used to correlate with biological activity to establish structure-activity plots. The mechanistically interpretable molecular descriptors used in this study include electrophilicity and the mathematical function in the London formula for dispersion interaction, and they were calculated using quantum chemical methods. The biological activity is the lethality of anthracycline anticancer antibiotics denoted as log LD50, which were obtained by intraperitoneal injection into mice. The results reveal that the plots for electrophilicity, which can be interpreted as redox reactivity of anthracyclines, can describe oxidative degradation for detoxification and reductive bioactivation for toxicity induction. The plots for the dispersion interaction function, which represent the attraction between anthracyclines and biomolecules, can describe efflux from and influx into target cells of toxicity. The plots can also identify three structural scaffolds of anthracyclines that have different metabolic pathways, resulting in their different toxicity behavior. This structure-dependent toxicity behavior revealed in the plots can provide perspectives on design of anthracycline anticancer antibiotics. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Structure of general-population antibody titer distributions to influenza A virus.

PubMed

Nhat, Nguyen Thi Duy; Todd, Stacy; de Bruin, Erwin; Thao, Tran Thi Nhu; Vy, Nguyen Ha Thao; Quan, Tran Minh; Vinh, Dao Nguyen; van Beek, Janko; Anh, Pham Hong; Lam, Ha Minh; Hung, Nguyen Thanh; Thanh, Nguyen Thi Le; Huy, Huynh Le Anh; Ha, Vo Thi Hong; Baker, Stephen; Thwaites, Guy E; Lien, Nguyen Thi Nam; Hong, Tran Thi Kim; Farrar, Jeremy; Simmons, Cameron P; Chau, Nguyen Van Vinh; Koopmans, Marion; Boni, Maciej F

2017-07-20

Seroepidemiological studies aim to understand population-level exposure and immunity to infectious diseases. Their results are normally presented as binary outcomes describing the presence or absence of pathogen-specific antibody, despite the fact that many assays measure continuous quantities. A population's natural distribution of antibody titers to an endemic infectious disease may include information on multiple serological states - naiveté, recent infection, non-recent infection, childhood infection - depending on the disease in question and the acquisition and waning patterns of immunity. In this study, we investigate 20,152 general-population serum samples from southern Vietnam collected between 2009 and 2013 from which we report antibody titers to the influenza virus HA1 protein using a continuous titer measurement from a protein microarray assay. We describe the distributions of antibody titers to subtypes 2009 H1N1 and H3N2. Using a model selection approach to fit mixture distributions, we show that 2009 H1N1 antibody titers fall into four titer subgroups and that H3N2 titers fall into three subgroups. For H1N1, our interpretation is that the two highest-titer subgroups correspond to recent and historical infection, which is consistent with 2009 pandemic attack rates. Similar interpretations are available for H3N2, but right-censoring of titers makes these interpretations difficult to validate.

Linking clinical measurements and kinematic gait patterns of toe-walking using fuzzy decision trees.

PubMed

Armand, Stéphane; Watelain, Eric; Roux, Emmanuel; Mercier, Moïse; Lepoutre, François-Xavier

2007-03-01

Toe-walking is one of the most prevalent gait deviations and has been linked to many diseases. Three major ankle kinematic patterns have been identified in toe-walkers, but the relationships between the causes of toe-walking and these patterns remain unknown. This study aims to identify these relationships. Clearly, such knowledge would increase our understanding of this gait deviation, and could help clinicians plan treatment. The large quantity of data provided by gait analysis often makes interpretation a difficult task. Artificial intelligence techniques were used in this study to facilitate interpretation as well as to decrease subjective interpretation. Of the 716 limbs evaluated, 240 showed signs of toe-walking and met inclusion criteria. The ankle kinematic pattern of the evaluated limbs during gait was assigned to one of three toe-walking pattern groups to build the training data set. Toe-walker clinical measurements (range of movement, muscle spasticity and muscle strength) were coded in fuzzy modalities, and fuzzy decision trees were induced to create intelligible rules allowing toe-walkers to be assigned to one of the three groups. A stratified 10-fold cross validation situated the classification accuracy at 81%. Twelve rules depicting the causes of toe-walking were selected, discussed and characterized using kinematic, kinetic and EMG charts. This study proposes an original approach to linking the possible causes of toe-walking with gait patterns.

Braving difficult choices alone: children's and adolescents' medical decision making.

PubMed

Ruggeri, Azzurra; Gummerum, Michaela; Hanoch, Yaniv

2014-01-01

What role should minors play in making medical decisions? The authors examined children's and adolescents' desire to be involved in serious medical decisions and the emotional consequences associated with them. Sixty-three children and 76 adolescents were presented with a cover story about a difficult medical choice. Participants were tested in one of four conditions: (1) own informed choice; (2) informed parents' choice to amputate; (3) informed parents' choice to continue a treatment; and (4) uninformed parents' choice to amputate. In a questionnaire, participants were asked about their choices, preference for autonomy, confidence, and emotional reactions when faced with a difficult hypothetical medical choice. Children and adolescents made different choices and participants, especially adolescents, preferred to make the difficult choice themselves, rather than having a parent make it. Children expressed fewer negative emotions than adolescents. Providing information about the alternatives did not affect participants' responses. Minors, especially adolescents, want to be responsible for their own medical decisions, even when the choice is a difficult one. For the adolescents, results suggest that the decision to be made, instead of the agent making the decision, is the main element influencing their emotional responses and decision confidence. For children, results suggest that they might be less able than adolescents to project how they would feel. The results, overall, draw attention to the need to further investigate how we can better involve minors in the medical decision-making process.

Movement patterns and study area boundaries: Influences on survival estimation in capture-mark-recapture studies

USGS Publications Warehouse

Horton, G.E.; Letcher, B.H.

2008-01-01

The inability to account for the availability of individuals in the study area during capture-mark-recapture (CMR) studies and the resultant confounding of parameter estimates can make correct interpretation of CMR model parameter estimates difficult. Although important advances based on the Cormack-Jolly-Seber (CJS) model have resulted in estimators of true survival that work by unconfounding either death or recapture probability from availability for capture in the study area, these methods rely on the researcher's ability to select a method that is correctly matched to emigration patterns in the population. If incorrect assumptions regarding site fidelity (non-movement) are made, it may be difficult or impossible as well as costly to change the study design once the incorrect assumption is discovered. Subtleties in characteristics of movement (e.g. life history-dependent emigration, nomads vs territory holders) can lead to mixtures in the probability of being available for capture among members of the same population. The result of these mixtures may be only a partial unconfounding of emigration from other CMR model parameters. Biologically-based differences in individual movement can combine with constraints on study design to further complicate the problem. Because of the intricacies of movement and its interaction with other parameters in CMR models, quantification of and solutions to these problems are needed. Based on our work with stream-dwelling populations of Atlantic salmon Salmo salar, we used a simulation approach to evaluate existing CMR models under various mixtures of movement probabilities. The Barker joint data model provided unbiased estimates of true survival under all conditions tested. The CJS and robust design models provided similarly unbiased estimates of true survival but only when emigration information could be incorporated directly into individual encounter histories. For the robust design model, Markovian emigration (future availability for capture depends on an individual's current location) was a difficult emigration pattern to detect unless survival and especially recapture probability were high. Additionally, when local movement was high relative to study area boundaries and movement became more diffuse (e.g. a random walk), local movement and permanent emigration were difficult to distinguish and had consequences for correctly interpreting the survival parameter being estimated (apparent survival vs true survival). ?? 2008 The Authors.

Software Reliability 2002

NASA Technical Reports Server (NTRS)

Wallace, Dolores R.

2003-01-01

In FY01 we learned that hardware reliability models need substantial changes to account for differences in software, thus making software reliability measurements more effective, accurate, and easier to apply. These reliability models are generally based on familiar distributions or parametric methods. An obvious question is 'What new statistical and probability models can be developed using non-parametric and distribution-free methods instead of the traditional parametric method?" Two approaches to software reliability engineering appear somewhat promising. The first study, begin in FY01, is based in hardware reliability, a very well established science that has many aspects that can be applied to software. This research effort has investigated mathematical aspects of hardware reliability and has identified those applicable to software. Currently the research effort is applying and testing these approaches to software reliability measurement, These parametric models require much project data that may be difficult to apply and interpret. Projects at GSFC are often complex in both technology and schedules. Assessing and estimating reliability of the final system is extremely difficult when various subsystems are tested and completed long before others. Parametric and distribution free techniques may offer a new and accurate way of modeling failure time and other project data to provide earlier and more accurate estimates of system reliability.

Review of splanchnic oximetry in clinical medicine

NASA Astrophysics Data System (ADS)

Bailey, Sean M.; Mally, Pradeep V.

2016-09-01

Global tissue perfusion and oxygenation are important indicators of physiologic function in humans. The monitoring of splanchnic oximetry through the use of near-infrared spectroscopy (NIRS) is an emerging method used to assess tissue oxygenation status. Splanchnic tissue oxygenation (SrS) is thought to be potentially of high value in critically ill patients because gastrointestinal organs can often be the first to suffer ischemic injury. During conditions of hypovolemia, cardiac dysfunction, or decreased oxygen-carrying capacity, blood flow is diverted toward vital organs, such as the brain and the heart at the expense of the splanchnic circulation. While monitoring SrS has great potential benefit, there are limitations to the technology and techniques. SrS has been found to have a relatively high degree of variability that can potentially make it difficult to interpret. In addition, because splanchnic organs only lie near the skin surface in children and infants, and energy from currently available sensors only penetrates a few centimeters deep, it can be difficult to use clinically in a noninvasive manner in adults. Research thus far is showing that splanchnic oximetry holds great promise in the ability to monitor patient oxygenation status and detect disease states in humans, especially in pediatric populations.

ReSeqTools: an integrated toolkit for large-scale next-generation sequencing based resequencing analysis.

PubMed

He, W; Zhao, S; Liu, X; Dong, S; Lv, J; Liu, D; Wang, J; Meng, Z

2013-12-04

Large-scale next-generation sequencing (NGS)-based resequencing detects sequence variations, constructs evolutionary histories, and identifies phenotype-related genotypes. However, NGS-based resequencing studies generate extraordinarily large amounts of data, making computations difficult. Effective use and analysis of these data for NGS-based resequencing studies remains a difficult task for individual researchers. Here, we introduce ReSeqTools, a full-featured toolkit for NGS (Illumina sequencing)-based resequencing analysis, which processes raw data, interprets mapping results, and identifies and annotates sequence variations. ReSeqTools provides abundant scalable functions for routine resequencing analysis in different modules to facilitate customization of the analysis pipeline. ReSeqTools is designed to use compressed data files as input or output to save storage space and facilitates faster and more computationally efficient large-scale resequencing studies in a user-friendly manner. It offers abundant practical functions and generates useful statistics during the analysis pipeline, which significantly simplifies resequencing analysis. Its integrated algorithms and abundant sub-functions provide a solid foundation for special demands in resequencing projects. Users can combine these functions to construct their own pipelines for other purposes.

The use of Spanish language skills by physicians and nurses: policy implications for teaching and testing.

PubMed

Diamond, Lisa C; Tuot, Delphine S; Karliner, Leah S

2012-01-01

Language barriers present a substantial communication challenge in the hospital setting. To describe how clinicians with various levels of Spanish language proficiency work with interpreters or their own Spanish skills in common clinical scenarios. Survey of physicians and nurses who report ever speaking Spanish with patients on a general medicine hospital floor. Spanish proficiency rated on a 5-point scale, self-reported use of specific strategies (own Spanish skills, professional or ad-hoc interpreters) to overcome the language barrier. Sixty-eight physicians and 65 nurses participated. Physicians with low-level Spanish proficiency reported frequent use of ad-hoc interpreters for all information-based scenarios, except pre-rounding in the morning when most reported using their own Spanish skills. For difficult conversations and procedural consent, most used professional interpreters. Comparatively, physicians with medium proficiency reported higher rates of using their own Spanish skills for information-based scenarios, lower rates of professional interpreter use, and little use of ad-hoc interpreters. They rarely used their own Spanish skills or ad-hoc interpreters for difficult conversations. Physicians with high-level Spanish proficiency almost uniformly reported using their own Spanish skills. The majority (82%) of nurses had low-level Spanish proficiency, and frequently worked with professional interpreters for educating patients, but more often used ad hoc interpreters and their own Spanish skills for information-based scenarios, including medication administration. Physicians and nurses with limited Spanish proficiency use these skills, even in important clinical circumstances in the hospital. Health-care organizations should evaluate clinicians' non-English language proficiency and set policies about use of language skills in clinical care.

The need for performance criteria in evaluating the durability of wood products

Treesearch

Stan Lebow; Bessie Woodward; Patricia Lebow; Carol Clausen

2010-01-01

Data generated from wood-product durability evaluations can be difficult to interpret. Standard methods used to evaluate the potential long-term durability of wood products often provide little guidance on interpretation of test results. Decisions on acceptable performance for standardization and code compliance are based on the judgment of reviewers or committees....

Identification and Small Sample Estimation of Thurstone's Unrestricted Model for Paired Comparisons Data

ERIC Educational Resources Information Center

Maydeu-Olivares, Alberto; Hernandez, Adolfo

2007-01-01

The interpretation of a Thurstonian model for paired comparisons where the utilities' covariance matrix is unrestricted proved to be difficult due to the comparative nature of the data. We show that under a suitable constraint the utilities' correlation matrix can be estimated, yielding a readily interpretable solution. This set of identification…

Deriving allowable properties of lumber : a practical guide for interpretation of ASTM standards

Treesearch

Alan Bendtsen; William L. Galligan

1978-01-01

The ASTM standards for establishing clear wood mechanical properties and for deriving structural grades and related allowable properties for visually graded lumber can be confusing and difficult for the uninitiated to interpret. This report provides a practical guide to using these standards for individuals not familiar with their application. Sample stress...

Comparing effects of low levels of herbicides on greehouse- and field-grown potatoes (Solanum tuberosum L.), soybeans (Glycine max L.) and peas (Pisum sataivum L.)

EPA Science Inventory

While laboratory toxicology tests are generally easy to perform, cost effective and readily interpreted, they have been questioned for their environmental relevance. In contrast, field tests are considered realistic while producing results that are difficult to interpret and exp...

Cognition and Self-Efficacy of Stratigraphy and Geologic Time: Implications for Improving Undergraduate Student Performance in Geological Reasoning

ERIC Educational Resources Information Center

Burton, Erin Peters; Mattietti, G. K.

2011-01-01

In general, integration of spatial information can be difficult for students. To study students' spatial thinking and their self-efficacy of interpreting stratigraphic columns, we designed an exercise that asks college-level students to interpret problems on the principles of superposition, original horizontality and lateral continuity, and…

AFOSR Contractors Meeting in Propulsion Held in Atlantic City, New Jersey on 14 - 18 June 1993

DTIC Science & Technology

1994-04-20

number is found to be much weaker, but not universal. Previous results in compressible shear layers are difficult to interpret as a con- sequence of...turbulence. Reference 9 provides new interpretation of measured spectra of reacting species in turbulence. RKF RENCES 1. Bilger, RW., Phys. Fluids A...A simple interpretation of Eq. (2) is that 0(n) (t) is drawn to its two neighbors at a rate proportional to its separation from them. Note that as

Abortion rights down under.

PubMed

Kirkby, M

1994-08-01

State and federal governments in Australia fear actively trying to ensure access to abortion. No federal abortion law in Australia exists. Abortion is a state matter. The federal government's health care system does reimburse women for abortion services, however. State laws prohibit unlawful abortions but they do not define what they mean by unlawful abortion. Victoria, New South Wales, and Queensland have had common law interpretations of their Crimes Acts, which allow greater access to abortion. Tasmania and Western Australia have not had common law interpretations. Thus, even though abortion is available, women and providers are not secure. Abortion reform in South Australia and the Northern Territory has made access to abortion more difficult. A woman must be a resident in South Australia for 2 months before she can obtain an abortion. Abortions are allowed only in a clinic or a hospital. Women in metropolitan Melbourne and Sydney have good access to abortion services, while those in the country or in an isolated part of NSW or Victoria may have an antiabortion physician serving their area. Women in Queensland, Tasmania, and Western Australia pay a lot for an abortion because they also have to pay for airfare to a large city. Only a gynecologist can perform abortions in the Northern Territory. Social workers often coerce Aboriginal women into an abortion. The few antiabortion physicians have a big impact on whether women receive abortion information or not. Research at Adelaide and Flinders Universities show that abortion-related trauma is linked to obtaining information and access to abortion services. Physicians are nervous about performing abortions because abortion is still in the Crimes Acts and Criminal Codes, making it difficult to recruit high quality and empathetic practitioners. Antiabortion groups are small and tend not to adopt extreme tactics. The Abortion Rights Network of Australia has recently been formed.

Magnetic resonance imaging evaluation after implantation of a titanium cervical disc prosthesis: a comparison of 1.5 and 3 Tesla magnet strength.

PubMed

Sundseth, Jarle; Jacobsen, Eva A; Kolstad, Frode; Nygaard, Oystein P; Zwart, John A; Hol, Per K

2013-10-01

Cervical disc prostheses induce significant amount of artifact in magnetic resonance imaging which may complicate radiologic follow-up after surgery. The purpose of this study was to investigate as to what extent the artifact, induced by the frequently used Discover(®) cervical disc prosthesis, impedes interpretation of the MR images at operated and adjacent levels in 1.5 and 3 Tesla MR. Ten subsequent patients were investigated in both 1.5 and 3 Tesla MR with standard image sequences one year following anterior cervical discectomy with arthroplasty. Two neuroradiologists evaluated the images by consensus. Emphasis was made on signal changes in medulla at all levels and visualization of root canals at operated and adjacent levels. A "blur artifact ratio" was calculated and defined as the height of the artifact on T1 sagittal images related to the operated level. The artifacts induced in 1.5 and 3 Tesla MR were of entirely different character and evaluation of the spinal cord at operated level was impossible in both magnets. Artifacts also made the root canals difficult to assess at operated level and more pronounced in the 3 Tesla MR. At the adjacent levels however, the spinal cord and root canals were completely visualized in all patients. The "blur artifact" induced at operated level was also more pronounced in the 3 Tesla MR. The artifact induced by the Discover(®) titanium disc prosthesis in both 1.5 and 3 Tesla MR, makes interpretation of the spinal cord impossible and visualization of the root canals difficult at operated level. Adjusting the MR sequences to produce the least amount of artifact is important.

A Practical Guide to Interpretation of Large Collections of Incident Narratives Using the QUORUM Method

NASA Technical Reports Server (NTRS)

McGreevy, Michael W.

1997-01-01

Analysis of incident reports plays an important role in aviation safety. Typically, a narrative description, written by a participant, is a central part of an incident report. Because there are so many reports, and the narratives contain so much detail, it can be difficult to efficiently and effectively recognize patterns among them. Recognizing and addressing recurring problems, however, is vital to continuing safety in commercial aviation operations. A practical way to interpret large collections of incident narratives is to apply the QUORUM method of text analysis, modeling, and relevance ranking. In this paper, QUORUM text analysis and modeling are surveyed, and QUORUM relevance ranking is described in detail with many examples. The examples are based on several large collections of reports from the Aviation Safety Reporting System (ASRS) database, and a collection of news stories describing the disaster of TWA Flight 800, the Boeing 747 which exploded in mid- air and crashed near Long Island, New York, on July 17, 1996. Reader familiarity with this disaster should make the relevance-ranking examples more understandable. The ASRS examples illustrate the practical application of QUORUM relevance ranking.

Cell differentiation and germ-soma separation in Ediacaran animal embryo-like fossils

NASA Astrophysics Data System (ADS)

Chen, Lei; Xiao, Shuhai; Pang, Ke; Zhou, Chuanming; Yuan, Xunlai

2014-12-01

Phosphorites of the Ediacaran Doushantuo Formation (~600 million years old) yield spheroidal microfossils with a palintomic cell cleavage pattern. These fossils have been variously interpreted as sulphur-oxidizing bacteria, unicellular protists, mesomycetozoean-like holozoans, green algae akin to Volvox, and blastula embryos of early metazoans or bilaterian animals. However, their complete life cycle is unknown and it is uncertain whether they had a cellularly differentiated ontogenetic stage, making it difficult to test their various phylogenetic interpretations. Here we describe new spheroidal fossils from black phosphorites of the Doushantuo Formation that have been overlooked in previous studies. These fossils represent later developmental stages of previously published blastula-like fossils, and they show evidence for cell differentiation, germ-soma separation, and programmed cell death. Their complex multicellularity is inconsistent with a phylogenetic affinity with bacteria, unicellular protists, or mesomycetozoean-like holozoans. Available evidence also indicates that the Doushantuo fossils are unlikely crown-group animals or volvocine green algae. We conclude that an affinity with cellularly differentiated multicellular eukaryotes, including stem-group animals or algae, is likely but more data are needed to constrain further the exact phylogenetic affinity of the Doushantuo fossils.

Cell differentiation and germ-soma separation in Ediacaran animal embryo-like fossils.

PubMed

Chen, Lei; Xiao, Shuhai; Pang, Ke; Zhou, Chuanming; Yuan, Xunlai

2014-12-11

Phosphorites of the Ediacaran Doushantuo Formation (∼600 million years old) yield spheroidal microfossils with a palintomic cell cleavage pattern. These fossils have been variously interpreted as sulphur-oxidizing bacteria, unicellular protists, mesomycetozoean-like holozoans, green algae akin to Volvox, and blastula embryos of early metazoans or bilaterian animals. However, their complete life cycle is unknown and it is uncertain whether they had a cellularly differentiated ontogenetic stage, making it difficult to test their various phylogenetic interpretations. Here we describe new spheroidal fossils from black phosphorites of the Doushantuo Formation that have been overlooked in previous studies. These fossils represent later developmental stages of previously published blastula-like fossils, and they show evidence for cell differentiation, germ-soma separation, and programmed cell death. Their complex multicellularity is inconsistent with a phylogenetic affinity with bacteria, unicellular protists, or mesomycetozoean-like holozoans. Available evidence also indicates that the Doushantuo fossils are unlikely crown-group animals or volvocine green algae. We conclude that an affinity with cellularly differentiated multicellular eukaryotes, including stem-group animals or algae, is likely but more data are needed to constrain further the exact phylogenetic affinity of the Doushantuo fossils.

Figuring Out Gas and Galaxies in Enzo (FOGGIE): Simulating effects of feedback on galactic outflows

NASA Astrophysics Data System (ADS)

Morris, Melissa Elizabeth; Corlies, Lauren; Peeples, Molly; Tumlinson, Jason; O'Shea, Brian; Smith, Britton

2018-01-01

The circumgalactic medium (CGM) is the region beyond the galactic disk in which gas is accreted through pristine inflows from the intergalactic medium and expelled from the galaxy by stellar feedback in large outflows that can then be recycled back onto the disk. These gas cycles connect the galactic disk with its cosmic environment, making the CGM a vital component of galaxy evolution. However, the CGM is primarily observed in absorption, which can be difficult to interpret. In this study, we use high resolution cosmological hydrodynamic simulations of a Milky Way mass halo evolved with the code Enzo to aid the interpretation of these observations. In our simulations, we vary feedback strength and observe the effect it has on galactic outflows and the evolution of the galaxy’s CGM. We compare the star formation rate of the galaxy with the velocity flux and mass outflow rate as a function of height above the plane of the galaxy in order to measure the strength of the outflows and how far they extend outside of the galaxy.This work was supported by The Space Astronomy Summer Program at STScI and NSF grant AST-1517908.

Ecosystem performance monitoring of rangelands by integrating modeling and remote sensing

USGS Publications Warehouse

Wylie, Bruce K.; Boyte, Stephen P.; Major, Donald J.

2012-01-01

Monitoring rangeland ecosystem dynamics, production, and performance is valuable for researchers and land managers. However, ecosystem monitoring studies can be difficult to interpret and apply appropriately if management decisions and disturbances are inseparable from the ecosystem's climate signal. This study separates seasonal weather influences from influences caused by disturbances and management decisions, making interannual time-series analysis more consistent and interpretable. We compared the actual ecosystem performance (AEP) of five rangeland vegetation types in the Owyhee Uplands for 9 yr to their expected ecosystem performance (EEP). Integrated growing season Normalized Difference Vegetation Index data for each of the nine growing seasons served as a proxy for annual AEP. Regression-tree models used long-term site potential, seasonal weather, and land cover data sets to generate annual EEP, an estimate of ecosystem performance incorporating annual weather variations. The difference between AEP and EEP provided a performance measure for each pixel in the study area. Ecosystem performance anomalies occurred when the ecosystem performed significantly better or worse than the model predicted. About 14% of the Owyhee Uplands showed a trend of significant underperformance or overperformance (P<0.10). Land managers can use results from weather-based rangeland ecosystem performance models to help support adaptive management strategies.

Auditory processing theories of language disorders: past, present, and future.

PubMed

Miller, Carol A

2011-07-01

The purpose of this article is to provide information that will assist readers in understanding and interpreting research literature on the role of auditory processing in communication disorders. A narrative review was used to summarize and synthesize the literature on auditory processing deficits in children with auditory processing disorder (APD), specific language impairment (SLI), and dyslexia. The history of auditory processing theories of these 3 disorders is described, points of convergence and controversy within and among the different branches of research literature are considered, and the influence of research on practice is discussed. The theoretical and clinical contributions of neurophysiological methods are also reviewed, and suggested approaches for critical reading of the research literature are provided. Research on the role of auditory processing in communication disorders springs from a variety of theoretical perspectives and assumptions, and this variety, combined with controversies over the interpretation of research results, makes it difficult to draw clinical implications from the literature. Neurophysiological research methods are a promising route to better understanding of auditory processing. Progress in theory development and its clinical application is most likely to be made when researchers from different disciplines and theoretical perspectives communicate clearly and combine the strengths of their approaches.

Automatic epileptic seizure detection using scalp EEG and advanced artificial intelligence techniques.

PubMed

Fergus, Paul; Hignett, David; Hussain, Abir; Al-Jumeily, Dhiya; Abdel-Aziz, Khaled

2015-01-01

The epilepsies are a heterogeneous group of neurological disorders and syndromes characterised by recurrent, involuntary, paroxysmal seizure activity, which is often associated with a clinicoelectrical correlate on the electroencephalogram. The diagnosis of epilepsy is usually made by a neurologist but can be difficult to be made in the early stages. Supporting paraclinical evidence obtained from magnetic resonance imaging and electroencephalography may enable clinicians to make a diagnosis of epilepsy and investigate treatment earlier. However, electroencephalogram capture and interpretation are time consuming and can be expensive due to the need for trained specialists to perform the interpretation. Automated detection of correlates of seizure activity may be a solution. In this paper, we present a supervised machine learning approach that classifies seizure and nonseizure records using an open dataset containing 342 records. Our results show an improvement on existing studies by as much as 10% in most cases with a sensitivity of 93%, specificity of 94%, and area under the curve of 98% with a 6% global error using a k-class nearest neighbour classifier. We propose that such an approach could have clinical applications in the investigation of patients with suspected seizure disorders.

Modeling resident error-making patterns in detection of mammographic masses using computer-extracted image features: preliminary experiments

NASA Astrophysics Data System (ADS)

Mazurowski, Maciej A.; Zhang, Jing; Lo, Joseph Y.; Kuzmiak, Cherie M.; Ghate, Sujata V.; Yoon, Sora

2014-03-01

Providing high quality mammography education to radiology trainees is essential, as good interpretation skills potentially ensure the highest benefit of screening mammography for patients. We have previously proposed a computer-aided education system that utilizes trainee models, which relate human-assessed image characteristics to interpretation error. We proposed that these models be used to identify the most difficult and therefore the most educationally useful cases for each trainee. In this study, as a next step in our research, we propose to build trainee models that utilize features that are automatically extracted from images using computer vision algorithms. To predict error, we used a logistic regression which accepts imaging features as input and returns error as output. Reader data from 3 experts and 3 trainees were used. Receiver operating characteristic analysis was applied to evaluate the proposed trainee models. Our experiments showed that, for three trainees, our models were able to predict error better than chance. This is an important step in the development of adaptive computer-aided education systems since computer-extracted features will allow for faster and more extensive search of imaging databases in order to identify the most educationally beneficial cases.

Between violation and competent care--lived experiences of dependency on care in the ICU.

PubMed

Lykkegaard, Kristina; Delmar, Charlotte

2015-01-01

This study explores the perceived meaning of dependency on care as experienced by intensive care patients. Research from non-intensive settings shows that dependency is often experienced negatively, but literature on the subject experienced by patients in the ICU is sparse. The study is based on in-depth qualitative semi-structured interviews of lived experience with three former patients admitted to an intensive care unit at a Danish university hospital. The in-depth interviews have been characterized as narratives. The main inspiration for the analysis method is Ricoeur's phenomenological hermeneutical interpretation theory. The study has found that dependency is experienced as difficult, and the relationship with the nurses seems to be ambivalent. The good relationship is experienced to make dependency easier, whereas negative experiences make it harder to cope with dependency. The participants deal with dependency by accepting negative experiences in gratitude for having recovered from critical illness. The findings might be influenced by studies being conducted in a western country setting where independence is valued. They can be used as means of reflection on nursing practice and matters such as communication and patient participation.

Depression and embodiment: phenomenological reflections on motility, affectivity, and transcendence.

PubMed

Aho, Kevin A

2013-11-01

This paper integrates personal narratives with the methods of phenomenology in order to draw some general conclusions about 'what it means' and 'what it feels like' to be depressed. The analysis has three parts. First, it explores the ways in which depression disrupts everyday experiences of spatial orientation and motility. This disruption makes it difficult for the person to move and perform basic functional tasks, resulting in a collapse or contraction of the life-world. Second, it illustrates how depression creates a situational atmosphere of emotional indifference that reduces the person's ability to qualitatively distinguish what matters in his or her life because nothing stands out as significant or important anymore. In this regard, depression is distinct from other feelings because it is not directed towards particular objects or situations but to the world as a whole. Finally, the paper examines how depression diminishes the possibility for 'self-creation' or 'self-making'. Restricted by the illness, depression becomes something of a destiny, preventing the person from being open and free to access a range of alternative self-interpretations, identities, and possible ways of being-in-the-world.

Characterization of Synthetic and Natural Manganese Oxides as Martian Analogues

NASA Technical Reports Server (NTRS)

Fox, V. K.; Arvidson, R. E.; Jolliff, B. L.; Carpenter, P. K.; Catalano, J. G.; Hinkle, M. A. G.; Morris, R. V.

2015-01-01

Recent discoveries of highly concentrated manganese oxides in Gale Crater and on the rim of Endeavour Crater by the Mars Science Laboratory Curiosity and Mars Exploration Rover Opportunity, respectively, imply more highly oxidizing aqueous conditions than previously recognized. Manganese oxides are a significant environmental indicator about ancient aqueous conditions, provided the phases can be characterized reliably. Manganese oxides are typically fine-grained and poorly crystalline, making the mineral structures difficult to determine, and they generally have very low visible reflectance with few distinctive spectral features in the visible to near infrared, making them a challenge for interpretation from remote sensing data. Therefore, these recent discoveries motivate better characterization using methods available on Mars, particularly visible to near infrared (VNIR) spectroscopy, X-ray diffractometry (XRD), and compositional measurements. Both rovers have complementary instruments in this regard. Opportunity is equipped with its multispectral visible imager, Pancam, and an Alpha Particle X-ray Spectrometer (APXS), and Curiosity has the multispectral Mastcam, ChemCam (laser-induced breakdown spectroscopy and passive spectroscopy), and APXS for in situ characterization, and ChemMin (XRD) for collected samples.

related: an R package for analysing pairwise relatedness from codominant molecular markers.

PubMed

Pew, Jack; Muir, Paul H; Wang, Jinliang; Frasier, Timothy R

2015-05-01

Analyses of pairwise relatedness represent a key component to addressing many topics in biology. However, such analyses have been limited because most available programs provide a means to estimate relatedness based on only a single estimator, making comparison across estimators difficult. Second, all programs to date have been platform specific, working only on a specific operating system. This has the undesirable outcome of making choice of relatedness estimator limited by operating system preference, rather than being based on scientific rationale. Here, we present a new R package, called related, that can calculate relatedness based on seven estimators, can account for genotyping errors, missing data and inbreeding, and can estimate 95% confidence intervals. Moreover, simulation functions are provided that allow for easy comparison of the performance of different estimators and for analyses of how much resolution to expect from a given data set. Because this package works in R, it is platform independent. Combined, this functionality should allow for more appropriate analyses and interpretation of pairwise relatedness and will also allow for the integration of relatedness data into larger R workflows. © 2014 John Wiley & Sons Ltd.

Measuring HPV vaccination coverage in Australia: comparing two alternative population-based denominators.

PubMed

Barbaro, Bianca; Brotherton, Julia M L

2015-08-01

To compare the use of two alternative population-based denominators in calculating HPV vaccine coverage in Australia by age groups, jurisdiction and remoteness areas. Data from the National HPV Vaccination Program Register (NHVPR) were analysed at Local Government Area (LGA) level, by state/territory and by the Australian Standard Geographical Classification Remoteness Structure. The proportion of females vaccinated was calculated using both the ABS ERP and Medicare enrolments as the denominator. HPV vaccine coverage estimates were slightly higher using Medicare enrolments than using the ABS estimated resident population nationally (70.8% compared with 70.4% for 12 to 17-year-old females, and 33.3% compared with 31.9% for 18 to 26-year-old females, respectively.) The greatest differences in coverage were found in the remote areas of Australia. There is minimal difference between coverage estimates made using the two denominators except in Remote and Very Remote areas where small residential populations make interpretation more difficult. Adoption of Medicare enrolments for the denominator in the ongoing program would make minimal, if any, difference to routine coverage estimates. © 2015 Public Health Association of Australia.

URBANIFE: a geographical information system for monitoring internal developments in an African traditional urban area

NASA Astrophysics Data System (ADS)

Nkambwe, Musisi

Data acquisition and information organization are major constraits in monitoring developments in traditional African urban environments. The internal arrangements and developments of housing units, land uses, communication routes, etc., in these urban areas make it difficult to use cadastral mapping techniques from other continents in building an information base useful for planning. In particular, sub-divisions of plots eventually make the "plot" less meaningful for planning as they are not recorded over time. Ideas expressed in an earlier proposal for a framework for an urban information system that included a temporal component to partially overcome this problem were used to build URBANIFE, a geographical information systemfor mapping and monitoring internal developments in the urban area of Ile-Ife, in southwestern Nigeria. URBANIFE provides an information system in which x- y coordinates from cadastral maps are used to identify the location of individual buildings, while multidate aerial photographs are interpreted and supplemented with field work to provide the temporal dimensions of some of the buildings' attributes considered important in planning and administration.

Challenges for a Sustainable Financial Foundation for Antimicrobial Stewardship.

PubMed

Dik, Jan-Willem H; Sinha, Bhanu

2017-03-30

Antimicrobial resistance is a worldwide threat and a problem with large clinical and economic impact. Antimicrobial Stewardship Programs are a solution to curb resistance development. A problem of resistance is a separation of actions and consequences, financial and clinical. Such a separation makes it difficult to create support among stakeholders leading to a lack of sense of responsibility. To counteract the resistance development it is important to perform diagnostics and know how to interpret the results. One should see diagnostics, therapy and resistance as one single process. Within this process all involved stakeholders need to work together on a more institutional level. We suggest therefore a solution: combining diagnostics and therapy into one single financial product . Such a product should act as an incentive to perform correct diagnostics. It also makes it easier to cover the costs of an antimicrobial stewardship program, which is often overlooked. Finally, such a product involves all stakeholders in the process and does not lay the costs at one stakeholder and the benefits somewhere else, solving the misbalance that is present nowadays.

Braving Difficult Choices Alone: Children's and Adolescents' Medical Decision Making

PubMed Central

Ruggeri, Azzurra; Gummerum, Michaela; Hanoch, Yaniv

2014-01-01

Objective What role should minors play in making medical decisions? The authors examined children's and adolescents' desire to be involved in serious medical decisions and the emotional consequences associated with them. Methods Sixty-three children and 76 adolescents were presented with a cover story about a difficult medical choice. Participants were tested in one of four conditions: (1) own informed choice; (2) informed parents' choice to amputate; (3) informed parents' choice to continue a treatment; and (4) uninformed parents' choice to amputate. In a questionnaire, participants were asked about their choices, preference for autonomy, confidence, and emotional reactions when faced with a difficult hypothetical medical choice. Results Children and adolescents made different choices and participants, especially adolescents, preferred to make the difficult choice themselves, rather than having a parent make it. Children expressed fewer negative emotions than adolescents. Providing information about the alternatives did not affect participants' responses. Conclusions Minors, especially adolescents, want to be responsible for their own medical decisions, even when the choice is a difficult one. For the adolescents, results suggest that the decision to be made, instead of the agent making the decision, is the main element influencing their emotional responses and decision confidence. For children, results suggest that they might be less able than adolescents to project how they would feel. The results, overall, draw attention to the need to further investigate how we can better involve minors in the medical decision-making process. PMID:25084274

The Effects of Aging on Clinical Vestibular Evaluations

PubMed Central

Maheu, Maxime; Houde, Marie-Soleil; Landry, Simon P.; Champoux, François

2015-01-01

Balance disorders are common issues for aging populations due to the effects of normal aging on peripheral vestibular structures. These changes affect the results of vestibular function evaluations and make the interpretation of these results more difficult. The objective of this article is to review the current state of knowledge of clinically relevant vestibular measures. We will first focus on otolith function assessment methods cervical-VEMP (cVEMP) and ocular-VEMP (oVEMP), then the caloric and video-head impulse test (vHIT) methods for semicircular canals assessment. cVEMP and oVEMP are useful methods, though research on the effects of age for some parameters are still inconclusive. vHIT results are largely independent of age as compared to caloric stimulation and should therefore be preferred for the evaluation of the semicircular canals function. PMID:26441824

C++ and data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Naumann, Axel; /CERN; Canal, Philippe

2008-01-01

High performance computing with a large code base and C++ has proved to be a good combination. But when it comes to storing data, C++ is a problematic choice: it offers no support for serialization, type definitions are amazingly complex to parse, and the dependency analysis (what does object A need to be stored?) is incredibly difficult. Nevertheless, the LHC data consists of C++ objects that are serialized with help from ROOT's reflection database and interpreter CINT. The fact that we can do it on that scale, and the performance with which we do it makes this approach unique andmore » stirs interest even outside HEP. I will show how CINT collects and stores information about C++ types, what the current major challenges are (dictionary size), and what CINT and ROOT have done and plan to do about it.« less

Group size in social-ecological systems.

PubMed

Casari, Marco; Tagliapietra, Claudio

2018-03-13

Cooperation becomes more difficult as a group becomes larger, but it is unclear where it will break down. Here, we study group size within well-functioning social-ecological systems. We consider centuries-old evidence from hundreds of communities in the Alps that harvested common property resources. Results show that the average group size remained remarkably stable over about six centuries, in contrast to a general increase in the regional population. The population more than doubled, but although single groups experienced fluctuations over time, the average group size remained stable. Ecological factors, such as managing forest instead of pasture land, played a minor role in determining group size. The evidence instead indicates that factors related to social interactions had a significant role in determining group size. We discuss possible interpretations of the findings based on constraints in individual cognition and obstacles in collective decision making.

Uncertain responses by humans and rhesus monkeys (Macaca mulatta) in a psychophysical same-different task

NASA Technical Reports Server (NTRS)

Shields, W. E.; Smith, J. D.; Washburn, D. A.; Rumbaugh, D. M. (Principal Investigator)

1997-01-01

The authors asked whether animals, like humans, use an uncertain response adaptively to escape indeterminate stimulus relations. Humans and monkeys were placed in a same-different task, known to be challenging for animals. Its difficulty was increased further by reducing the size of the stimulus differences, thereby making many same and different trials difficult to tell apart. Monkeys do escape selectively from these threshold trials, even while coping with 7 absolute stimulus levels concurrently. Monkeys even adjust their response strategies on short time scales according to the local task conditions. Signal-detection and optimality analyses confirm the similarity of humans' and animals' performances. Whereas associative interpretations account poorly for these results, an intuitive uncertainty construct does so easily. The authors discuss the cognitive processes that allow uncertainty's adaptive use and recommend further comparative studies of metacognition.

Formalin preservation of avian blood for organochlorine analysis

USGS Publications Warehouse

Stafford, C.J.; Stickel, W.H.; Lamb, D.W.; Kenaga, E.E.

1981-01-01

Blood biopsy for chemical analysis is a valuable technique for evaluating chemical exposure of birds in the wild without harming the birds. Field conditions, however, often make sample storage difficult. Better methods than freezing are needed to improve the interpretive value of chemical analysis of the sample. The use of formalin was explored for this purpose. A pooled sample of blood containing naturally incorporated 1,1-bis-(p-chlorophenyl)-2,2,2-trichloroethane (DDT), 2,2-bis-(p-chlorophenyl)1,1 dichloroethylene (DDE), and dieldrin was subdivided into 30 samples, of which 10 were frozen, 10 more were kept at room temperature, and 10 were formalinized by adding I part of chemically pure formalin to 20 parts of blood. The formalinized samples yielded the highest and least variable concentrations of chemicals. The field procedures are outlined.

The Power of Refutational Text: Changing Intuitions about the Interpretation of Box Plots

ERIC Educational Resources Information Center

Lem, Stephanie; Onghena, Patrick; Verschaffel, Lieven; Van Dooren, Wim

2017-01-01

Graphicacy is an important skill in today's society; however, the interpretation of graphs proofs to be more difficult than it might seem. In this study, we focus on one specific misinterpretation, the area misinterpretation of box plots, which is caused by incorrect heuristic processing of salient features of the box plot. In this study, we tried…

The Ability of Grade 5 Students To Use Radarsat Satellite Images.

ERIC Educational Resources Information Center

Kirman, Joseph M.; Busby, Stephanie

2000-01-01

A study examined the ability of 32 grade-5 students in Alberta (Canada) to interpret Radarsat satellite radar images. The students were able to interpret most elements of the images, but working directly with the CD-ROM proved too difficult for them. The Radarsat images have limited value as a geographic resource at the grade-5 level. (TD)

Quantitative Ultrasound Imaging Using Acoustic Backscatter Coefficients.

NASA Astrophysics Data System (ADS)

Boote, Evan Jeffery

Current clinical ultrasound scanners render images which have brightness levels related to the degree of backscattered energy from the tissue being imaged. These images offer the interpreter a qualitative impression of the scattering characteristics of the tissue being examined, but due to the complex factors which affect the amplitude and character of the echoed acoustic energy, it is difficult to make quantitative assessments of scattering nature of the tissue, and thus, difficult to make precise diagnosis when subtle disease effects are present. In this dissertation, a method of data reduction for determining acoustic backscatter coefficients is adapted for use in forming quantitative ultrasound images of this parameter. In these images, the brightness level of an individual pixel corresponds to the backscatter coefficient determined for the spatial position represented by that pixel. The data reduction method utilized rigorously accounts for extraneous factors which affect the scattered echo waveform and has been demonstrated to accurately determine backscatter coefficients under a wide range of conditions. The algorithms and procedures used to form backscatter coefficient images are described. These were tested using tissue-mimicking phantoms which have regions of varying scattering levels. Another phantom has a fat-mimicking layer for testing these techniques under more clinically relevant conditions. Backscatter coefficient images were also formed of in vitro human liver tissue. A clinical ultrasound scanner has been adapted for use as a backscatter coefficient imaging platform. The digital interface between the scanner and the computer used for data reduction are described. Initial tests, using phantoms are presented. A study of backscatter coefficient imaging of in vivo liver was performed using several normal, healthy human subjects.

Helping Resource Managers Understand Hydroclimatic Variability and Forecasts: A Case Study in Research Equity

NASA Astrophysics Data System (ADS)

Hartmann, H. C.; Pagano, T. C.; Sorooshian, S.; Bales, R.

2002-12-01

Expectations for hydroclimatic research are evolving as changes in the contract between science and society require researchers to provide "usable science" that can improve resource management policies and practices. However, decision makers have a broad range of abilities to access, interpret, and apply scientific research. "High-end users" have technical capabilities and operational flexibility capable of readily exploiting new information and products. "Low-end users" have fewer resources and are less likely to change their decision making processes without clear demonstration of benefits by influential early adopters (i.e., high-end users). Should research programs aim for efficiency, targeting high-end users? Should they aim for impact, targeting decisions with high economic value or great influence (e.g., state or national agencies)? Or should they focus on equity, whereby outcomes benefit groups across a range of capabilities? In this case study, we focus on hydroclimatic variability and forecasts. Agencies and individuals responsible for resource management decisions have varying perspectives about hydroclimatic variability and opportunities for using forecasts to improve decision outcomes. Improper interpretation of forecasts is widespread and many individuals find it difficult to place forecasts in an appropriate regional historical context. In addressing these issues, we attempted to mitigate traditional inequities in the scope, communication, and accessibility of hydroclimatic research results. High-end users were important in prioritizing information needs, while low-end users were important in determining how information should be communicated. For example, high-end users expressed hesitancy to use seasonal forecasts in the absence of quantitative performance evaluations. Our subsequently developed forecast evaluation framework and research products, however, were guided by the need for a continuum of evaluation measures and interpretive materials to enable low-end users to increase their understanding of probabilistic forecasts, credibility concepts, and implications for decision making. We also developed an interactive forecast assessment tool accessible over the Internet, to support resource decisions by individuals as well as agencies. The tool provides tutorials for guiding forecast interpretation, including quizzes that allow users to test their forecast interpretation skills. Users can monitor recent and historical observations for selected regions, communicated using terminology consistent with available forecast products. The tool also allows users to evaluate forecast performance for the regions, seasons, forecast lead times, and performance criteria relevant to their specific decision making situations. Using consistent product formats, the evaluation component allows individuals to use results at the level they are capable of understanding, while offering opportunity to shift to more sophisticated criteria. Recognizing that many individuals lack Internet access, the forecast assessment webtool design also includes capabilities for customized report generation so extension agents or other trusted information intermediaries can provide material to decision makers at meetings or site visits.

CrossTalk, The Journal of Defense Software Engineering. Volume 27, Number 4. July/August 2014

DTIC Science & Technology

2014-07-01

hires him for the work.” To do this with a development project, isolate parts of the sys- tem the development of which is not obvious and develop...class. Coupling makes it more difficult to isolate units of code for testing. The interdependence also makes code comprehension more difficult and...coupled, it is more difficult or impossible to isolate the module under test to ensure the test is focusing only on the desired code and producing

Current understanding of decision-making in adolescents with cancer: A narrative systematic review

PubMed Central

Day, Emma; Jones, Louise; Langner, Richard; Bluebond-Langner, Myra

2016-01-01

Background: Policy guidance and bioethical literature urge the involvement of adolescents in decisions about their healthcare. It is uncertain how roles and expectations of adolescents, parents and healthcare professionals influence decision-making and to what extent this is considered in guidance. Aims: To identify recent empirical research on decision-making regarding care and treatment in adolescent cancer: (1) to synthesise evidence to define the role of adolescents, parents and healthcare professionals in the decision-making process and (2) to identify gaps in research. Design: A narrative systematic review of qualitative, quantitative and mixed-methods research. We adopted a textual approach to synthesis, using a theoretical framework of interactionism to interpret findings. Data Sources: The databases MEDLINE, PsycINFO, SCOPUS, EMBASE and CINHAL were searched from 2001 through May 2015 for publications on decision-making for adolescents (13–19 years) with cancer. Results: Twenty-eight articles were identified. Adolescents and parents initially find it difficult to participate in decision-making due to a lack of options in the face of protocol-driven care. Parent and adolescent preferences for information and response to loss of control vary between individuals and over time. No studies indicate parental or adolescent preference for a high degree of independence in decision-making. Conclusion: Striving to make parents and adolescents fully informed or urge them towards more independence than they prefer may add to distress and confusion. This may interfere with their ability to participate in their preferred way in decisions about care and treatment. Future research should include analysis of on-ground interactions among parents, adolescents and clinicians across the trajectory. PMID:27160700

DAFi: A directed recursive data filtering and clustering approach for improving and interpreting data clustering identification of cell populations from polychromatic flow cytometry data.

PubMed

Lee, Alexandra J; Chang, Ivan; Burel, Julie G; Lindestam Arlehamn, Cecilia S; Mandava, Aishwarya; Weiskopf, Daniela; Peters, Bjoern; Sette, Alessandro; Scheuermann, Richard H; Qian, Yu

2018-04-17

Computational methods for identification of cell populations from polychromatic flow cytometry data are changing the paradigm of cytometry bioinformatics. Data clustering is the most common computational approach to unsupervised identification of cell populations from multidimensional cytometry data. However, interpretation of the identified data clusters is labor-intensive. Certain types of user-defined cell populations are also difficult to identify by fully automated data clustering analysis. Both are roadblocks before a cytometry lab can adopt the data clustering approach for cell population identification in routine use. We found that combining recursive data filtering and clustering with constraints converted from the user manual gating strategy can effectively address these two issues. We named this new approach DAFi: Directed Automated Filtering and Identification of cell populations. Design of DAFi preserves the data-driven characteristics of unsupervised clustering for identifying novel cell subsets, but also makes the results interpretable to experimental scientists through mapping and merging the multidimensional data clusters into the user-defined two-dimensional gating hierarchy. The recursive data filtering process in DAFi helped identify small data clusters which are otherwise difficult to resolve by a single run of the data clustering method due to the statistical interference of the irrelevant major clusters. Our experiment results showed that the proportions of the cell populations identified by DAFi, while being consistent with those by expert centralized manual gating, have smaller technical variances across samples than those from individual manual gating analysis and the nonrecursive data clustering analysis. Compared with manual gating segregation, DAFi-identified cell populations avoided the abrupt cut-offs on the boundaries. DAFi has been implemented to be used with multiple data clustering methods including K-means, FLOCK, FlowSOM, and the ClusterR package. For cell population identification, DAFi supports multiple options including clustering, bisecting, slope-based gating, and reversed filtering to meet various autogating needs from different scientific use cases. © 2018 International Society for Advancement of Cytometry. © 2018 International Society for Advancement of Cytometry.

Comparative Effectiveness of a Mnemonic-Use Approach vs. Self-Study to Interpret a Lateral Chest X-Ray

ERIC Educational Resources Information Center

Thompson, Michael; Johansen, Dallin; Stoner, Russell; Jarsted, Allison; Sorrells, Robert; McCarroll, Michele L.; Justice, Wade

2017-01-01

The chest X-ray is the most commonly performed medical imaging study; however, the lateral chest film intimidates many physicians and medical students. The lateral view is more difficult to interpret than the frontal view but provides important information that is either not visible or not as evident on frontal view, and inability to read it may…

Making sense of sexual orientation measures: findings from a cognitive processing study with adolescents on health survey questions.

PubMed

Austin, S Bryn; Conron, Kerith; Patel, Aarti; Freedner, Naomi

2007-01-01

To carry out a study using cognitive processing interview methods to explore ways in which adolescents understand sexual orientation questions currently used on epidemiologic surveys. In-depth, individual interviews were conducted to probe cognitive processes involved in answering four self-report survey questions assessing sexual identity, sexual attraction, and sex of sexual partners.A semi-structured interview guide was used to explore variation in question interpretation, information retrieval patterns and problems, item clarity, valence of reactions to items (positive, negative, neutral), respondent burden, and perceived threat associated with the measures. Thirty adolescents aged 15 to 21 of diverse sexual orientations and race/ethnicities participated in the study, including female, male, and transgender youth. A question on sexual attraction was the most consistently understood and thus was easy for nearly all youth to answer. In contrast, a measure of sexual identity with options heterosexual, bisexual, gay/lesbian, and unsure was the most difficult to answer. Most preferred a sexual identity item that also provided the intermediate options mostly heterosexual and mostly homosexual, which many said reflected their experience of feeling between categories. Participants had varying and inconsistent interpretations of sexual behavior terms, such as sex and sexual intercourse, used in assessing the sex of sexual partners. Differences in understanding could affect interpretation of survey data in important ways. Development of valid measures of sexual orientation will be essential to better monitor health disparities.

Ecobat: An online resource to facilitate transparent, evidence-based interpretation of bat activity data.

PubMed

Lintott, Paul R; Davison, Sophie; van Breda, John; Kubasiewicz, Laura; Dowse, David; Daisley, Jonathan; Haddy, Emily; Mathews, Fiona

2018-01-01

Acoustic surveys of bats are one of the techniques most commonly used by ecological practitioners. The results are used in Ecological Impact Assessments to assess the likely impacts of future developments on species that are widely protected in law, and to monitor developments' postconstruction. However, there is no standardized methodology for analyzing or interpreting these data, which can make the assessment of the ecological value of a site very subjective. Comparisons of sites and projects are therefore difficult for ecologists and decision-makers, for example, when trying to identify the best location for a new road based on relative bat activity levels along alternative routes. Here, we present a new web-based, data-driven tool, Ecobat, which addresses the need for a more robust way of interpreting ecological data. Ecobat offers users an easy, standardized, and objective method for analyzing bat activity data. It allows ecological practitioners to compare bat activity data at regional and national scales and to generate a numerical indicator of the relative importance of a night's worth of bat activity. The tool is free and open-source; because the underlying algorithms are already developed, it could easily be expanded to new geographical regions and species. Data donation is required to ensure the robustness of the analyses; we use a positive feedback mechanism to encourage ecological practitioners to share data by providing in return high quality, contextualized data analysis, and graphical visualizations for direct use in ecological reports.

You are lost without a map: Navigating the sea of protein structures.

PubMed

Lamb, Audrey L; Kappock, T Joseph; Silvaggi, Nicholas R

2015-04-01

X-ray crystal structures propel biochemistry research like no other experimental method, since they answer many questions directly and inspire new hypotheses. Unfortunately, many users of crystallographic models mistake them for actual experimental data. Crystallographic models are interpretations, several steps removed from the experimental measurements, making it difficult for nonspecialists to assess the quality of the underlying data. Crystallographers mainly rely on "global" measures of data and model quality to build models. Robust validation procedures based on global measures now largely ensure that structures in the Protein Data Bank (PDB) are largely correct. However, global measures do not allow users of crystallographic models to judge the reliability of "local" features in a region of interest. Refinement of a model to fit into an electron density map requires interpretation of the data to produce a single "best" overall model. This process requires inclusion of most probable conformations in areas of poor density. Users who misunderstand this can be misled, especially in regions of the structure that are mobile, including active sites, surface residues, and especially ligands. This article aims to equip users of macromolecular models with tools to critically assess local model quality. Structure users should always check the agreement of the electron density map and the derived model in all areas of interest, even if the global statistics are good. We provide illustrated examples of interpreted electron density as a guide for those unaccustomed to viewing electron density. Copyright © 2014 Elsevier B.V. All rights reserved.

Baking a mass-spectrometry data PIE with McMC and simulated annealing: predicting protein post-translational modifications from integrated top-down and bottom-up data.

PubMed

Jefferys, Stuart R; Giddings, Morgan C

2011-03-15

Post-translational modifications are vital to the function of proteins, but are hard to study, especially since several modified isoforms of a protein may be present simultaneously. Mass spectrometers are a great tool for investigating modified proteins, but the data they provide is often incomplete, ambiguous and difficult to interpret. Combining data from multiple experimental techniques-especially bottom-up and top-down mass spectrometry-provides complementary information. When integrated with background knowledge this allows a human expert to interpret what modifications are present and where on a protein they are located. However, the process is arduous and for high-throughput applications needs to be automated. This article explores a data integration methodology based on Markov chain Monte Carlo and simulated annealing. Our software, the Protein Inference Engine (the PIE) applies these algorithms using a modular approach, allowing multiple types of data to be considered simultaneously and for new data types to be added as needed. Even for complicated data representing multiple modifications and several isoforms, the PIE generates accurate modification predictions, including location. When applied to experimental data collected on the L7/L12 ribosomal protein the PIE was able to make predictions consistent with manual interpretation for several different L7/L12 isoforms using a combination of bottom-up data with experimentally identified intact masses. Software, demo projects and source can be downloaded from http://pie.giddingslab.org/

A Generalized Approach for the Interpretation of Geophysical Well Logs in Ground-Water Studies - Theory and Application

USGS Publications Warehouse

Paillet, Frederick L.; Crowder, R.E.

1996-01-01

Quantitative analysis of geophysical logs in ground-water studies often involves at least as broad a range of applications and variation in lithology as is typically encountered in petroleum exploration, making such logs difficult to calibrate and complicating inversion problem formulation. At the same time, data inversion and analysis depend on inversion model formulation and refinement, so that log interpretation cannot be deferred to a geophysical log specialist unless active involvement with interpretation can be maintained by such an expert over the lifetime of the project. We propose a generalized log-interpretation procedure designed to guide hydrogeologists in the interpretation of geophysical logs, and in the integration of log data into ground-water models that may be systematically refined and improved in an iterative way. The procedure is designed to maximize the effective use of three primary contributions from geophysical logs: (1) The continuous depth scale of the measurements along the well bore; (2) The in situ measurement of lithologic properties and the correlation with hydraulic properties of the formations over a finite sample volume; and (3) Multiple independent measurements that can potentially be inverted for multiple physical or hydraulic properties of interest. The approach is formulated in the context of geophysical inversion theory, and is designed to be interfaced with surface geophysical soundings and conventional hydraulic testing. The step-by-step procedures given in our generalized interpretation and inversion technique are based on both qualitative analysis designed to assist formulation of the interpretation model, and quantitative analysis used to assign numerical values to model parameters. The approach bases a decision as to whether quantitative inversion is statistically warranted by formulating an over-determined inversion. If no such inversion is consistent with the inversion model, quantitative inversion is judged not possible with the given data set. Additional statistical criteria such as the statistical significance of regressions are used to guide the subsequent calibration of geophysical data in terms of hydraulic variables in those situations where quantitative data inversion is considered appropriate.

Computer model analysis of the radial artery pressure waveform.

PubMed

Schwid, H A; Taylor, L A; Smith, N T

1987-10-01

Simultaneous measurements of aortic and radial artery pressures are reviewed, and a model of the cardiovascular system is presented. The model is based on resonant networks for the aorta and axillo-brachial-radial arterial system. The model chosen is a simple one, in order to make interpretation of the observed relationships clear. Despite its simplicity, the model produces realistic aortic and radial artery pressure waveforms. It demonstrates that the resonant properties of the arterial wall significantly alter the pressure waveform as it is propagated from the aorta to the radial artery. Although the mean and end-diastolic radial pressures are usually accurate estimates of the corresponding aortic pressures, the systolic pressure at the radial artery is often much higher than that of the aorta due to overshoot caused by the resonant behavior of the radial artery. The radial artery dicrotic notch is predominantly dependent on the axillo-brachial-radial arterial wall properties, rather than on the aortic valve or peripheral resistance. Hence the use of the radial artery dicrotic notch as an estimate of end systole is unreliable. The rate of systolic upstroke, dP/dt, of the radial artery waveform is a function of many factors, making it difficult to interpret. The radial artery waveform usually provides accurate estimates for mean and diastolic aortic pressures; for all other measurements it is an inadequate substitute for the aortic pressure waveform. In the presence of low forearm peripheral resistance the mean radial artery pressure may significantly underestimate the mean aortic pressure, as explained by a voltage divider model.

Effectiveness of communication strategies for deaf or hard of hearing workers in group settings.

PubMed

Haynes, Scott

2014-01-01

In group settings, background noise and an obstructed view of the speaker are just a few of the issues that can make workplace communication difficult for an individual who is deaf or hard of hearing. Accommodation strategies such as amplification of the speaker's voice or the use of text-based alternatives exist to address these issues. However, recent studies have shown that there are still unmet needs related to workplace communication in group settings for individuals who are deaf or hard of hearing. Identify the most common strategies used by individuals who are deaf or hard of hearing to improve communication in group settings and gauge the perceived effectiveness of those strategies. An online survey was conducted with individuals who self-identified as deaf or hard of hearing. The survey presented specific communication strategies based on three functional approaches (aural/oral, text, visual). The strategies applied to both receptive and expressive communication in five different meeting types ranging in size and purpose. 161 adults (age 22-90 yrs.) with limited hearing ability completed the survey. Text-based strategies were typically the least frequently used strategies in group settings, yet they ranked high in perceived effectiveness for receptive and expressive communication. Those who used an interpreter demonstrated a strong preference for having a qualified interpreter present in the meeting rather than an interpreter acting remotely. For expressive communication, participants in general preferred to use their own voice or signing abilities and ranked those strategies as highly effective. A more accessible workplace for individuals who are deaf or hard of hearing would incorporate more ubiquitous text-based strategy options. Also, qualified interpreters, when used, should be present in the meeting for maximum effectiveness.

Cancer Counseling of Low-Income Limited English Proficient Latina Women Using Medical Interpreters: Implications for Shared Decision-Making.

PubMed

Kamara, Daniella; Weil, Jon; Youngblom, Janey; Guerra, Claudia; Joseph, Galen

2018-02-01

In cancer genetic counseling (CGC), communication across language and culture challenges the model of practice based on shared decision-making. To date, little research has examined the decision-making process of low-income, limited English proficiency (LEP) patients in CGC. This study identified communication patterns in CGC sessions with this population and assessed how these patterns facilitate or inhibit the decision-making process during the sessions. We analyzed 24 audio recordings of CGC sessions conducted in Spanish via telephone interpreters at two public hospitals. Patients were referred for risk of hereditary breast and ovarian cancer; all were offered genetic testing. Audio files were coded by two bilingual English-Spanish researchers and analyzed using conventional content analysis through an iterative process. The 24 sessions included 13 patients, 6 counselors, and 18 interpreters. Qualitative data analyses identified three key domains - Challenges Posed by Hypothetical Explanations, Misinterpretation by the Medical Interpreter, and Communication Facilitators - that reflect communication patterns and their impact on the counselor's ability to facilitate shared decision-making. Overall, we found an absence of patient participation in the decision-making process. Our data suggest that when counseling LEP Latina patients via medical interpreter, prioritizing information with direct utility for the patient and organizing information into short- and long-term goals may reduce information overload and improve comprehension for patient and interpreter. Further research is needed to test the proposed counseling strategies with this population and to assess how applicable our findings are to other populations.

VIIRS captures phytoplankton vertical migration in the NE Gulf of Mexico.

PubMed

Qi, Lin; Hu, Chuanmin; Barnes, Brian B; Lee, Zhongping

2017-06-01

In summer 2014, a toxic Karenia brevis bloom (red tide) occurred in the NE Gulf of Mexico, during which vertical migration of K. brevis has been observed from glider measurements. The current study shows that satellite observations from the Visible Infrared Imaging Radiometer Suite (VIIRS) can capture changes in surface reflectance and chlorophyll concentration occurring within 2h, which may be attributed this K. brevis vertical migration. The argument is supported by earlier glider measurements in the same bloom, by the dramatic changes in the VIIRS-derived surface chlorophyll, and by the consistency between the short-term reflectance changes and those reported earlier from field-measured K. brevis vertical migration. Estimates using the quasi-analytical algorithm also indicate significant increases in both total absorption coefficient and backscattering coefficient in two hours. The two observations in a day from a single polar-orbiting satellite sensor are thus shown to be able to infer phytoplankton vertical movement within a short timeframe, a phenomenon difficult to capture with other sensors as each sensor can provide at most one observation per day, and cross-sensor inconsistency may make interpretation of merged-sensor data difficult. These findings strongly support geostationary satellite missions to study short-term bloom dynamics. Copyright © 2017 Elsevier B.V. All rights reserved.

Persistence of an Oncogenic Papillomavirus Genome Requires cis Elements from the Viral Transcriptional Enhancer

PubMed Central

Van Doorslaer, Koenraad; Chen, Dan; Chapman, Sandra; Khan, Jameela

2017-01-01

ABSTRACT Human papillomavirus (HPV) genomes are replicated and maintained as extrachromosomal plasmids during persistent infection. The viral E2 proteins are thought to promote stable maintenance replication by tethering the viral DNA to host chromatin. However, this has been very difficult to prove genetically, as the E2 protein is involved in transcriptional regulation and initiation of replication, as well as its assumed role in genome maintenance. This makes mutational analysis of viral trans factors and cis elements in the background of the viral genome problematic and difficult to interpret. To circumvent this problem, we have developed a complementation assay in which the complete wild-type HPV18 genome is transfected into primary human keratinocytes along with subgenomic or mutated replicons that contain the minimal replication origin. The wild-type genome provides the E1 and E2 proteins in trans, allowing us to determine additional cis elements that are required for long-term replication and partitioning of the replicon. We found that, in addition to the core replication origin (and the three E2 binding sites located therein), additional sequences from the transcriptional enhancer portion of the URR (upstream regulatory region) are required in cis for long-term genome replication. PMID:29162712

BAYESIAN PROTEIN STRUCTURE ALIGNMENT.

PubMed

Rodriguez, Abel; Schmidler, Scott C

The analysis of the three-dimensional structure of proteins is an important topic in molecular biochemistry. Structure plays a critical role in defining the function of proteins and is more strongly conserved than amino acid sequence over evolutionary timescales. A key challenge is the identification and evaluation of structural similarity between proteins; such analysis can aid in understanding the role of newly discovered proteins and help elucidate evolutionary relationships between organisms. Computational biologists have developed many clever algorithmic techniques for comparing protein structures, however, all are based on heuristic optimization criteria, making statistical interpretation somewhat difficult. Here we present a fully probabilistic framework for pairwise structural alignment of proteins. Our approach has several advantages, including the ability to capture alignment uncertainty and to estimate key "gap" parameters which critically affect the quality of the alignment. We show that several existing alignment methods arise as maximum a posteriori estimates under specific choices of prior distributions and error models. Our probabilistic framework is also easily extended to incorporate additional information, which we demonstrate by including primary sequence information to generate simultaneous sequence-structure alignments that can resolve ambiguities obtained using structure alone. This combined model also provides a natural approach for the difficult task of estimating evolutionary distance based on structural alignments. The model is illustrated by comparison with well-established methods on several challenging protein alignment examples.

Inherited structure and coupled crust-mantle lithosphere evolution: Numerical models of Central Australia

NASA Astrophysics Data System (ADS)

Heron, Philip J.; Pysklywec, Russell N.

2016-05-01

Continents have a rich tectonic history that have left lasting crustal impressions. In analyzing Central Australian intraplate orogenesis, complex continental features make it difficult to identify the controls of inherited structure. Here the tectonics of two types of inherited structures (e.g., a thermally enhanced or a rheologically strengthened region) are compared in numerical simulations of continental compression with and without "glacial buzzsaw" erosion. We find that although both inherited structures produce deformation in the upper crust that is confined to areas where material contrasts, patterns of deformation in the deep lithosphere differ significantly. Furthermore, our models infer that glacial buzzsaw erosion has little impact at depth. This tectonic isolation of the mantle lithosphere from glacial processes may further assist in the identification of a controlling inherited structure in intraplate orogenesis. Our models are interpreted in the context of Central Australian tectonics (specifically the Petermann and Alice Springs orogenies).

Mass Spectrometry Imaging Can Distinguish on a Proteomic Level Between Proliferative Nodules Within a Benign Congenital Nevus and Malignant Melanoma.

PubMed

Lazova, Rossitza; Yang, Zhe; El Habr, Constantin; Lim, Young; Choate, Keith Adam; Seeley, Erin H; Caprioli, Richard M; Yangqun, Li

2017-09-01

Histopathological interpretation of proliferative nodules occurring in association with congenital melanocytic nevi can be very challenging due to their similarities with congenital malignant melanoma and malignant melanoma arising in association with congenital nevi. We hereby report a diagnostically challenging case of congenital melanocytic nevus with proliferative nodules and ulcerations, which was originally misdiagnosed as congenital malignant melanoma. Subsequent histopathological examination in consultation by one of the authors (R.L.) and mass spectrometry imaging analysis rendered a diagnosis of congenital melanocytic nevus with proliferative nodules. In this case, mass spectrometry imaging, a novel method capable of distinguishing benign from malignant melanocytic lesions on a proteomic level, was instrumental in making the diagnosis of a benign nevus. We emphasize the importance of this method as an ancillary tool in the diagnosis of difficult melanocytic lesions.

[Addison disease during pregnancy--a diagnostic dilemma. Symptoms are similar to normal pregnancy problems].

PubMed

Wålinder, Olov

The symptoms of primary adrenocortical insufficiency (Addison's disease) such as fatigue, anorexia, hypotension and hyperpigmentation are similar to those of normal pregnancy. Addison's disease is rare and the diagnosis can easily be overlooked during pregnancy. The concentration of corticosteroid-binding globulin (CBG) and cortisol in serum as well as urinary free cortisol increase 2-3 times during pregnancy. Therefore, the reference ranges for nonpregnant persons cannot be used during pregnancy. The diagnosis of Addison's disease in pregnancy should be based on analysis of p-ACTH which remains within the reference range in normal pregnancy until delivery. A case of Addison's disease diagnosed during pregnancy is presented and it illustrates the diagnostic difficulties. In patients taking oral estrogen containing contraceptives, serum levels of CBG and cortisol also increase 2-3 times, making s-cortisol values difficult to interpret. Also in these patients, analysis of p-ACTH is of value when suspecting Addison's disease.

Small-signal modulation characteristics of a polariton laser

PubMed Central

Zunaid Baten, Md; Frost, Thomas; Iorsh, Ivan; Deshpande, Saniya; Kavokin, Alexey; Bhattacharya, Pallab

2015-01-01

Use of large bandgap materials together with electrical injection makes the polariton laser an attractive low-power coherent light source for medical and biomedical applications or short distance plastic fiber communication at short wavelengths (violet and ultra-violet), where a conventional laser is difficult to realize. The dynamic properties of a polariton laser have not been investigated experimentally. We have measured, for the first time, the small signal modulation characteristics of a GaN-based electrically pumped polariton laser operating at room temperature. A maximum −3 dB modulation bandwidth of 1.18 GHz is measured. The experimental results have been analyzed with a theoretical model based on the Boltzmann kinetic equations and the agreement is very good. We have also investigated frequency chirping during such modulation. Gain compression phenomenon in a polariton laser is interpreted and a value is obtained for the gain compression factor. PMID:26154681

The dorsal anterior cingulate cortex is selective for pain: Results from large-scale reverse inference

PubMed Central

Lieberman, Matthew D.; Eisenberger, Naomi I.

2015-01-01

Dorsal anterior cingulate cortex (dACC) activation is commonly observed in studies of pain, executive control, conflict monitoring, and salience processing, making it difficult to interpret the dACC’s specific psychological function. Using Neurosynth, an automated brainmapping database [of over 10,000 functional MRI (fMRI) studies], we performed quantitative reverse inference analyses to explore the best general psychological account of the dACC function P(Ψ process|dACC activity). Results clearly indicated that the best psychological description of dACC function was related to pain processing—not executive, conflict, or salience processing. We conclude by considering that physical pain may be an instance of a broader class of survival-relevant goals monitored by the dACC, in contrast to more arbitrary temporary goals, which may be monitored by the supplementary motor area. PMID:26582792

The Role of Text Messaging in Cardiovascular Risk Factor Optimization.

PubMed

Klimis, Harry; Khan, Mohammad Ehsan; Kok, Cindy; Chow, Clara K

2017-01-01

Many cases of CVD may be avoidable through lowering behavioural risk factors such as smoking and physical inactivity. Mobile health (mHealth) provides a novel opportunity to deliver cardiovascular prevention programs in a format that is potentially scalable. Here, we provide an overview of text messaging-based mHealth interventions in cardiovascular prevention. Text messaging-based interventions appear effective on a range of behavioural risk factors and can effect change on multiple risk factors-e.g. smoking, weight, blood pressure-simultaneously. For many texting studies, there are challenges in interpretation as many texting interventions are part of larger complex interventions making it difficult to determine the benefits of the separate components. Whilst there is evidence for text messaging improving cardiovascular risk factor levels in the short-term, future studies are needed to examine the durability of these effects and whether they can be translated to improvements in clinical care and outcomes.

DOE Office of Scientific and Technical Information (OSTI.GOV)

T. H. Brikowski; D. L. Norton; D. D. Blackwell

Final project report of natural state modeling effort for The Geysers geothermal field, California. Initial models examined the liquid-dominated state of the system, based on geologic constraints and calibrated to match observed whole rock delta-O18 isotope alteration. These models demonstrated that the early system was of generally low permeability (around 10{sup -12} m{sup 2}), with good hydraulic connectivity at depth (along the intrusive contact) and an intact caprock. Later effort in the project was directed at development of a two-phase, supercritical flow simulation package (EOS1sc) to accompany the Tough2 flow simulator. Geysers models made using this package show that ''simmering'',more » or the transient migration of vapor bubbles through the hydrothermal system, is the dominant transition state as the system progresses to vapor-dominated. Such a system is highly variable in space and time, making the rock record more difficult to interpret, since pressure-temperature indicators likely reflect only local, short duration conditions.« less

Multi-objective game-theory models for conflict analysis in reservoir watershed management.

PubMed

Lee, Chih-Sheng

2012-05-01

This study focuses on the development of a multi-objective game-theory model (MOGM) for balancing economic and environmental concerns in reservoir watershed management and for assistance in decision. Game theory is used as an alternative tool for analyzing strategic interaction between economic development (land use and development) and environmental protection (water-quality protection and eutrophication control). Geographic information system is used to concisely illustrate and calculate the areas of various land use types. The MOGM methodology is illustrated in a case study of multi-objective watershed management in the Tseng-Wen reservoir, Taiwan. The innovation and advantages of MOGM can be seen in the results, which balance economic and environmental concerns in watershed management and which can be interpreted easily by decision makers. For comparison, the decision-making process using conventional multi-objective method to produce many alternatives was found to be more difficult. Copyright © 2012 Elsevier Ltd. All rights reserved.

Physiologic basis for understanding quantitative dehydration assessment.

PubMed

Cheuvront, Samuel N; Kenefick, Robert W; Charkoudian, Nisha; Sawka, Michael N

2013-03-01

Dehydration (body water deficit) is a physiologic state that can have profound implications for human health and performance. Unfortunately, dehydration can be difficult to assess, and there is no single, universal gold standard for decision making. In this article, we review the physiologic basis for understanding quantitative dehydration assessment. We highlight how phenomenologic interpretations of dehydration depend critically on the type (dehydration compared with volume depletion) and magnitude (moderate compared with severe) of dehydration, which in turn influence the osmotic (plasma osmolality) and blood volume-dependent compensatory thresholds for antidiuretic and thirst responses. In particular, we review new findings regarding the biological variation in osmotic responses to dehydration and discuss how this variation can help provide a quantitative and clinically relevant link between the physiology and phenomenology of dehydration. Practical measures with empirical thresholds are provided as a starting point for improving the practice of dehydration assessment.

CT, MRI and PET imaging in peritoneal malignancy

PubMed Central

Sahdev, Anju; Reznek, Rodney H.

2011-01-01

Abstract Imaging plays a vital role in the evaluation of patients with suspected or proven peritoneal malignancy. Nevertheless, despite significant advances in imaging technology and protocols, assessment of peritoneal pathology remains challenging. The combination of complex peritoneal anatomy, an extensive surface area that may host tumour deposits and the considerable overlap of imaging appearances of various peritoneal diseases often makes interpretation difficult. Contrast-enhanced multidetector computed tomography (MDCT) remains the most versatile tool in the imaging of peritoneal malignancy. However, conventional and emerging magnetic resonance imaging (MRI) and positron emission tomography (PET)/CT techniques offer significant advantages over MDCT in detection and surveillance. This article reviews established and new techniques in CT, MRI and PET imaging in both primary and secondary peritoneal malignancies and provides an overview of peritoneal anatomy, function and modes of disease dissemination with illustration of common sites and imaging features of peritoneal malignancy. PMID:21865109

Quantitative radiographic analysis of fiber reinforced polymer composites.

PubMed

Baidya, K P; Ramakrishna, S; Rahman, M; Ritchie, A

2001-01-01

X-ray radiographic examination of the bone fracture healing process is a widely used method in the treatment and management of patients. Medical devices made of metallic alloys reportedly produce considerable artifacts that make the interpretation of radiographs difficult. Fiber reinforced polymer composite materials have been proposed to replace metallic alloys in certain medical devices because of their radiolucency, light weight, and tailorable mechanical properties. The primary objective of this paper is to provide a comparable radiographic analysis of different fiber reinforced polymer composites that are considered suitable for biomedical applications. Composite materials investigated consist of glass, aramid (Kevlar-29), and carbon reinforcement fibers, and epoxy and polyether-ether-ketone (PEEK) matrices. The total mass attenuation coefficient of each material was measured using clinical X-rays (50 kev). The carbon fiber reinforced composites were found to be more radiolucent than the glass and kevlar fiber reinforced composites.

Gene Delivery to Postnatal Rat Brain by Non-ventricular Plasmid Injection and Electroporation

PubMed Central

Molotkov, Dmitry A.; Yukin, Alexey Y.; Afzalov, Ramil A.; Khiroug, Leonard S.

2010-01-01

Creation of transgenic animals is a standard approach in studying functions of a gene of interest in vivo. However, many knockout or transgenic animals are not viable in those cases where the modified gene is expressed or deleted in the whole organism. Moreover, a variety of compensatory mechanisms often make it difficult to interpret the results. The compensatory effects can be alleviated by either timing the gene expression or limiting the amount of transfected cells. The method of postnatal non-ventricular microinjection and in vivo electroporation allows targeted delivery of genes, siRNA or dye molecules directly to a small region of interest in the newborn rodent brain. In contrast to conventional ventricular injection technique, this method allows transfection of non-migratory cell types. Animals transfected by means of the method described here can be used, for example, for two-photon in vivo imaging or in electrophysiological experiments on acute brain slices. PMID:20972387

Patrescence in Southern Thailand: cosmological and social dimensions of fatherhood among the Malay-Muslims.

PubMed

Merli, Claudia

2011-12-01

This paper examines fatherhood among the Malay Muslims of Southern Thailand (representing a minority at the national level, but constituting the majority population in the region). Traditional practices related to birth and the postpartum period are upheld as a marker of ethnic and religious identity by such groups. Building on the concept of patrescence as 'becoming a father', proposed by Dana Raphael, the data presented show how the process of assuming fatherhood develops during pregnancy and continues after birth through a series of ritual practices in which a man contributes to female postpartum practices. The medicalisation of birth in synergy with recent literalist interpretations of Islam has impacted on these practices, making it difficult to comply with the ritual burial of the afterbirth, which constitutes the cosmological and physical anchoring of individual and ethnic identity to the soil.

Harmonisation of microbial sampling and testing methods for distillate fuels

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hill, G.C.; Hill, E.C.

1995-05-01

Increased incidence of microbial infection in distillate fuels has led to a demand for organisations such as the Institute of Petroleum to propose standards for microbiological quality, based on numbers of viable microbial colony forming units. Variations in quality requirements, and in the spoilage significance of contaminating microbes plus a tendency for temporal and spatial changes in the distribution of microbes, makes such standards difficult to implement. The problem is compounded by a diversity in the procedures employed for sampling and testing for microbial contamination and in the interpretation of the data obtained. The following paper reviews these problems andmore » describes the efforts of The Institute of Petroleum Microbiology Fuels Group to address these issues and in particular to bring about harmonisation of sampling and testing methods. The benefits and drawbacks of available test methods, both laboratory based and on-site, are discussed.« less

The Rise and Fall of Pentaquarks in Experiments

NASA Astrophysics Data System (ADS)

Schumacher, Reinhard A.

2006-07-01

Experimental evidence for and against the existence of pentaquarks has accumulated rapidly in the last three years. If they exist, they would be dramatic examples of hadronic states beyond our well-tested and successful particle models. The positive evidence suggests existence of baryonic objects with widths of at most a few MeV, some displaying exotic quantum numbers, such as baryons with strangeness S = +1. The non-observations of these states have often come from reaction channels very different from the positive evidence channels, making comparisons difficult. The situation has now been largely clarified, however, by high-statistics repetitions of the positive sightings, with the result that none of the positive sightings have been convincingly reproduced. The most recent unconfirmed positive sightings suffer again from low statistics and large backgrounds. It seems that a kind of "bandwagon" effect led to the overly-optimistic interpretation of numerous experiments in the earlier reports of exotic pentaquarks.

Regulating pharmaceutical advertising: What will work?

PubMed Central

Shapiro, M F

1997-01-01

As Dr. Joel Lexchin makes painfully obvious in this issue (see pages 351 to 356), regulatory processes governing pharmaceutical advertising in Canada and elsewhere are seriously compromised. However, the remedial measures Lexchin proposes are not sufficient. Financial sanctions against improper advertising are likely to be regarded by manufacturers as the cost of doing business, and any regulatory body that includes drug industry representatives or individuals receiving financial support from the drug industry cannot be genuinely independent. Moreover, manufacturers are now using promotional strategies that are particularly difficult to regulate. These include providing drugs at lower than the usual cost to ensure their inclusion in managed-care formularies, and using direct-to-consumer advertising to take advantage of the public's lack of sophistication in interpreting scientific evidence. Our best hope of counteracting the power and influence of the drug industry lies in regulation by government agencies, whose interest is the protection of the public. PMID:9033416

Recovery of damage in rad-hard MOS devices during and after irradiation by electrons, protons, alphas, and gamma rays

NASA Technical Reports Server (NTRS)

Brucker, G. J.; Van Gunten, O.; Stassinopoulos, E. G.; Shapiro, P.; August, L. S.; Jordan, T. M.

1983-01-01

This paper reports on the recovery properties of rad-hard MOS devices during and after irradiation by electrons, protons, alphas, and gamma rays. The results indicated that complex recovery properties controlled the damage sensitivities of the tested parts. The results also indicated that damage sensitivities depended on dose rate, total dose, supply bias, gate bias, transistor type, radiation source, and particle energy. The complex nature of these dependencies make interpretation of LSI device performance in space (exposure to entire electron and proton spectra) difficult, if not impossible, without respective ground tests and analyses. Complete recovery of n-channel shifts was observed, in some cases within hours after irradiation, with equilibrium values of threshold voltages greater than their pre-irradiation values. This effect depended on total dose, radiation source, and gate bias during exposure. In contrast, the p-channel shifts recovered only 20 percent within 30 days after irradiation.

Risk in the pursuit of benefit

DOE Office of Scientific and Technical Information (OSTI.GOV)

Terra, S.

1978-11-01

A summer conference was held by the Electric Power Research Institute (EPRI) Advisory Council to discuss the impact of energy production on health and the environment. The government's role as a funding agent for energy research includes disseminating risk assessments to the public. This was faulted by some, particularly in the area of nuclear energy. Conferees disagreed over the quality and interpretation of data that government agencies release to the public, but agreed that public confusion over goals and acceptable risks makes it difficult for regulators. Legislation and court decisions, often responding to pressure-group influence, are constantly shifting the balancemore » between individual and societal goals even though there is often little correlation between statistical and perceived risks. A refocusing of the concept of hazards and the criteria for risks was recommended, and a set of new guidelines for technology risk assessment was suggested that ignores minor risks, bans large risks and actively studies all others.« less

The Long Way Toward Cooperation

PubMed Central

Block, Karen; Stamer, Maren; Schmacke, Norbert

2015-01-01

To better understand why cooperation between health care professionals is still often problematic, we carried out 25 semistructured face-to-face expert interviews with physicians and nurses in different rural and urban areas in northern Germany. Using Mayring’s qualitative content analysis method to analyze the data collected, we found that doctors and nurses interpreted interprofessional conflicts differently. Nursing seems to be caught in a paradoxical situation: An increasing emphasis is placed on achieving interprofessional cooperation but the core areas of nursing practice are subject to increasing rationalization in the current climate of health care marketization. The subsequent and systematic devaluation of nursing work makes it difficult for physicians to acknowledge nurses’ expertise. We suggest that to ameliorate interprofessional cooperation, nursing must insist on its own logic of action thereby promoting its professionalization; interprofessional cooperation cannot take place until nursing work is valued by all members of the health care system. PMID:28462297

Regulating pharmaceutical advertising: what will work?

PubMed

Shapiro, M F

1997-02-01

As Dr. Joel Lexchin makes painfully obvious in this issue (see pages 351 to 356), regulatory processes governing pharmaceutical advertising in Canada and elsewhere are seriously compromised. However, the remedial measures Lexchin proposes are not sufficient. Financial sanctions against improper advertising are likely to be regarded by manufacturers as the cost of doing business, and any regulatory body that includes drug industry representatives or individuals receiving financial support from the drug industry cannot be genuinely independent. Moreover, manufacturers are now using promotional strategies that are particularly difficult to regulate. These include providing drugs at lower than the usual cost to ensure their inclusion in managed-care formularies, and using direct-to-consumer advertising to take advantage of the public's lack of sophistication in interpreting scientific evidence. Our best hope of counteracting the power and influence of the drug industry lies in regulation by government agencies, whose interest is the protection of the public.

Significant Scales in Community Structure

NASA Astrophysics Data System (ADS)

Traag, V. A.; Krings, G.; van Dooren, P.

2013-10-01

Many complex networks show signs of modular structure, uncovered by community detection. Although many methods succeed in revealing various partitions, it remains difficult to detect at what scale some partition is significant. This problem shows foremost in multi-resolution methods. We here introduce an efficient method for scanning for resolutions in one such method. Additionally, we introduce the notion of ``significance'' of a partition, based on subgraph probabilities. Significance is independent of the exact method used, so could also be applied in other methods, and can be interpreted as the gain in encoding a graph by making use of a partition. Using significance, we can determine ``good'' resolution parameters, which we demonstrate on benchmark networks. Moreover, optimizing significance itself also shows excellent performance. We demonstrate our method on voting data from the European Parliament. Our analysis suggests the European Parliament has become increasingly ideologically divided and that nationality plays no role.

Mapping the function of neuronal ion channels in model and experiment

PubMed Central

Podlaski, William F; Seeholzer, Alexander; Groschner, Lukas N; Miesenböck, Gero; Ranjan, Rajnish; Vogels, Tim P

2017-01-01

Ion channel models are the building blocks of computational neuron models. Their biological fidelity is therefore crucial for the interpretation of simulations. However, the number of published models, and the lack of standardization, make the comparison of ion channel models with one another and with experimental data difficult. Here, we present a framework for the automated large-scale classification of ion channel models. Using annotated metadata and responses to a set of voltage-clamp protocols, we assigned 2378 models of voltage- and calcium-gated ion channels coded in NEURON to 211 clusters. The IonChannelGenealogy (ICGenealogy) web interface provides an interactive resource for the categorization of new and existing models and experimental recordings. It enables quantitative comparisons of simulated and/or measured ion channel kinetics, and facilitates field-wide standardization of experimentally-constrained modeling. DOI: http://dx.doi.org/10.7554/eLife.22152.001 PMID:28267430

Experiences of mental health nursing staff working with voice hearers in an acute setting: An interpretive phenomenological approach.

PubMed

McMullan, E; Gupta, A; Collins, S C

2018-04-01

WHAT IS KNOWN ON THE SUBJECT?: Community mental health staff and their service users have reported mixed views on the importance of talking about the content of voices. Community staff have reported feeling that they do not have the skills to explore voice content and worry about making things worse. Voice hearers experiencing extreme distress due to the content of their voices can access support through acute inpatient mental health services. No previous studies have focused on the experiences of staff who nurse voice hearers at a time of acute distress. WHAT DOES THIS STUDY ADD TO EXISTING KNOWLEDGE?: MHNs and HSWs working with voice hearers in acute distress report feeling powerless and helpless, as they feel that they cannot lessen the distress experienced by the voice hearer. Despite these difficult feelings, staff report finding ways of coping, including using structured tools to help make sense of their service users' voice-hearing experiences and accessing reflective practice forums. WHAT ARE THE IMPLICATIONS FOR PRACTICE?: Due to the current context of increased acuity and limited resources in acute services, there may be a need to further protect time for staff to access reflective practice groups and supervision forums to help them manage the difficult feelings arising from their work with voice hearers. Introduction Mental health nursing (MHN) staff in acute settings work with voice hearers at times of crises when they experience high levels of distress. Previous research has focused on community mental health staff's experiences and their service users views on exploring the content of voices. No studies have explored this from an acute mental health service perspective. Aim This study therefore sought to explore the experiences of staff working with voice hearers in an acute mental health service. Method Due to the exploratory nature of the research, a qualitative design was chosen. Three MHNs and five healthcare support workers (HSWs) were interviewed. The data were analysed using Interpretative Phenomenological Analysis. Results A group analysis elicited three master themes: "It's quite scary really, not unlike a horror movie;" "I can only influence what's in front of me;" and "Just chipping away". Discussion Staff working with voice hearers in acute settings experience feelings of powerlessness and helplessness, as they feel unable to reduce the distress experienced by voice hearers in their care. Staff employ coping strategies to help manage these difficult feelings, including using structured tools in their work with voice hearers and attending reflective practice forums. Implications for Practice Acute mental health services may need to protect time for staff to access regular reflective practice and other supervision forums to help manage their feelings of powerlessness and helplessness arising from their work with voice hearers. © 2017 John Wiley & Sons Ltd.

Collegiate Connections: Music Education Budget Crisis

ERIC Educational Resources Information Center

Slaton, Emily Dawn

2012-01-01

Due to the current recession, the American economy within the last few years has taken a nosedive, making it difficult for national, state, and local governments to support all the programs they currently have in place. There are difficult choices that need to be made about where to make sacrifices in their budgets so things can still run…

Explaining Difficult Ideas: Spotting, Tackling, and Rendering Them Sensible for Lay Readers.

ERIC Educational Resources Information Center

Rowan, Katherine E.

1990-01-01

Offers a definition of explanatory text, and summarizes research on why abstract concepts and principles are difficult for lay readers to understand. Describes a three-week unit for composition classes on spotting difficult ideas, diagnosing the type of difficulty they pose, and selecting the text features most likely to make them less difficult.…

Making Sense of the ECG - Cases for Self-Assessment Houghton Andrew R Gray David Making Sense of the ECG - Cases for Self-Assessment 290pp Hodder Education 9780340946893 034094689X [Formula: see text].

PubMed

2010-10-27

This practical, pocket-book approach to ECG interpretation accompanies the well-known text Making Sense of the ECG, by the same authors. It is also designed to be used alone to test knowledge of ECG interpretation and to make clinical decisions based on presented scenarios.

Making sense of the ECG: cases for self-assessment Making Sense of the ECG: Cases for Self-Assessment Houghton Andrew and Gray David Hodder Education £18.99 290pp 9780340946893 034094689X [Formula: see text].

PubMed

2011-02-10

This practical pocket-book approach to electrocardiogram (ECG) interpretation accompanies Making sense of the eCg by the same authors. it is also designed to be used alone to test knowledge of ECG interpretation and to make clinical decisions based on presented scenarios.

Human Information Behavior, Coping, and Decision-Making in the Context of a Personal Crisis: An Interpretative Phenomenological Analysis of the Voices of Birthmothers on Relinquishing a Child for Adoption

ERIC Educational Resources Information Center

Clemens, Rachael Annette

2017-01-01

This qualitative and interpretive inquiry explores the information behavior of birthmothers surrounding the processes of decision-making, coping, and living with the act of child relinquishment to adoption. An interpretative phenomenological analysis methodology is used to reveal the phenomenon as experienced by eight birthmothers, women who…

Where systems biology meets postharvest

USDA-ARS?s Scientific Manuscript database

Interpreting fruit metabolism, particularly tree fruit metabolism, presents unique challenges. Long periods from tree establishment to fruiting render techniques directed towards reducing the complexity of metabolic mechanisms, such as genomic modification, relatively difficult. Consequently, holi...

Voltammetric and Mathematical Evidence for Dual Transport Mediation of Serotonin Clearance In Vivo

PubMed Central

Wood, Kevin M.; Zeqja, Anisa; Nijhout, H. Frederik; Reed, Michael C.; Best, Janet; Hashemi, Parastoo

2014-01-01

The neurotransmitter serotonin underlies many of the brain’s functions. Understanding serotonin neurochemistry is important for improving treatments for neuropsychiatric disorders such as depression. Antidepressants commonly target serotonin clearance via serotonin transporters (SERTs) and have variable clinical effects. Adjunctive therapies, targeting other systems including serotonin autoreceptors, also vary clinically and carry adverse consequences. Fast scan cyclic voltammetry (FSCV) is particularly well suited for studying antidepressant effects on serotonin clearance and autoreceptors by providing real-time chemical information on serotonin kinetics in vivo. However, the complex nature of in vivo serotonin responses makes it difficult to interpret experimental data with established kinetic models. Here, we electrically stimulated the mouse medial forebrain bundle (MFB) to provoke and detect terminal serotonin in the substantia nigra reticulata (SNr). In response to MFB stimulation we found three dynamically distinct serotonin signals. To interpret these signals we developed a computational model that supports two independent serotonin reuptake mechanisms (high affinity, low efficiency reuptake mechanism and low affinity, high efficiency reuptake system) and bolsters an important inhibitory role for the serotonin autoreceptors. Our data and analysis, afforded by the powerful combination of voltammetric and theoretical methods, gives new understanding of the chemical heterogeneity of serotonin dynamics in the brain. This diverse serotonergic matrix likely contributes to clinical variability of antidepressants. PMID:24702305

Characterizing Adversity of Lysosomal Accumulation in Nonclinical Toxicity Studies: Results from the 5th ESTP International Expert Workshop.

PubMed

Lenz, B; Braendli-Baiocco, A; Engelhardt, J; Fant, P; Fischer, H; Francke, S; Fukuda, R; Gröters, S; Harada, T; Harleman, H; Kaufmann, W; Kustermann, S; Nolte, T; Palazzi, X; Pohlmeyer-Esch, G; Popp, A; Romeike, A; Schulte, A; Lima, B Silva; Tomlinson, L; Willard, J; Wood, C E; Yoshida, M

2018-02-01

Lysosomes have a central role in cellular catabolism, trafficking, and processing of foreign particles. Accumulation of endogenous and exogenous materials in lysosomes represents a common finding in nonclinical toxicity studies. Histologically, these accumulations often lack distinctive features indicative of lysosomal or cellular dysfunction, making it difficult to consistently interpret and assign adverse dose levels. To help address this issue, the European Society of Toxicologic Pathology organized a workshop where representative types of lysosomal accumulation induced by pharmaceuticals and environmental chemicals were presented and discussed. The expert working group agreed that the diversity of lysosomal accumulations requires a case-by-case weight-of-evidence approach and outlined several factors to consider in the adversity assessment, including location and type of cell affected, lysosomal contents, severity of the accumulation, and related pathological effects as evidence of cellular or organ dysfunction. Lysosomal accumulations associated with cytotoxicity, inflammation, or fibrosis were generally considered to be adverse, while those found in isolation (without morphologic or functional consequences) were not. Workshop examples highlighted the importance of thoroughly characterizing the biological context of lysosomal effects, including mechanistic data and functional in vitro readouts if available. The information provided here should facilitate greater consistency and transparency in the interpretation of lysosomal effects.

X-ray astronomy in the laboratory with a miniature compact object produced by laser-driven implosion

NASA Astrophysics Data System (ADS)

Fujioka, Shinsuke; Takabe, Hideaki; Yamamoto, Norimasa; Salzmann, David; Wang, Feilu; Nishimura, Hiroaki; Li, Yutong; Dong, Quanli; Wang, Shoujun; Zhang, Yi; Rhee, Yong-Joo; Lee, Yong-Woo; Han, Jae-Min; Tanabe, Minoru; Fujiwara, Takashi; Nakabayashi, Yuto; Zhao, Gang; Zhang, Jie; Mima, Kunioki

2009-11-01

X-ray spectroscopy is an important tool for understanding the extreme photoionization processes that drive the behaviour of non-thermal equilibrium plasmas in compact astrophysical objects such as black holes. Even so, the distance of these objects from the Earth and the inability to control or accurately ascertain the conditions that govern their behaviour makes it difficult to interpret the origin of the features in astronomical X-ray measurements. Here, we describe an experiment that uses the implosion driven by a 3TW, 4kJ laser system to produce a 0.5keV blackbody radiator that mimics the conditions that exist in the neighbourhood of a black hole. The X-ray spectra emitted from photoionized silicon plasmas resemble those observed from the binary stars Cygnus X-3 (refs 7, 8) and Vela X-1 (refs 9, 10 11) with the Chandra X-ray satellite. As well as demonstrating the ability to create extreme radiation fields in a laboratory plasma, our theoretical interpretation of these laboratory spectra contrasts starkly with the generally accepted explanation for the origin of similar features in astronomical observations. Our experimental approach offers a powerful means to test and validate the computer codes used in X-ray astronomy.

Giant Planets in Reflected Light: What Science Can We Expect?

NASA Technical Reports Server (NTRS)

Marley, Mark

2016-01-01

Interpreting the reflection spectra of cool giant planets will be a challenge. Spectra of such worlds are expected to be primarily shaped by scattering from clouds and hazes and punctuated by absorption bands of methane, water, and ammonia. While the warmest giants may be cloudless, their atmospheres will almost certainly sport substantial photochemical hazes. Furthermore the masses of most direct imaging targets will be constrained by radial velocity observations, their radii, and thus atmospheric gravity, will be imperfectly known. The uncertainty in planet radius and gravity will compound with uncertain aerosol properties to make estimation of key absorber abundances difficult. To address such concerns our group is developing atmospheric retrieval tools to constrain quantities of interest, particular gas mixing ratios. We have applied our Markov Chain Monte Carlo methods to simulated data of the quality expected from the WFIRST CGI instrument and found that given sufficiently high SNR data we can confidentially identify and constrain the abundance of methane, cloud top pressures, gravity, and the star-planet-observer phase angle. In my presentation I will explain the expected characteristics of cool extrasolar giant planet reflection spectra, discuss these and other challenges in their interpretation, and summarize the science results we can expect from direct imaging observations.

The distribution of particulate material on Mars

NASA Technical Reports Server (NTRS)

Christensen, Philip R.

1991-01-01

The surface materials on Mars were extensively studied using a variety of spacecraft and Earth-based remote sensing observations. These measurements include: (1) diurnal thermal measurements, used to determine average particle size, rock abundance, and the presence of crusts; (2) radar observations, used to estimate the surface slope distributions, wavelength scale roughness, and density; (3) radio emission observations, used to estimate subsurface density; (4) broadband albedo measurements, used to study the time variation of surface brightness and dust deposition and removal; and (5) color observations, used to infer composition, mixing, and the presence of crusts. Remote sensing observations generally require some degree of modeling to interpret, making them more difficult to interpret than direct observations from the surface. They do, however, provide a means for examining the surface properties over the entire planet and a means of sampling varying depths within the regolith. Albedo and color observations only indicate the properties of the upper-most few microns, but are very sensitive to thin, sometimes emphemeral dust coatings. Thermal observations sample the upper skin depth, generally 2 to 10 cm. Rock abundance measurements give an indirect indication of surface mantling, where the absence of rocks suggests mantles of several meters. Finally, radar and radio emission data can penetrate several meters into the surface, providing an estimate of subsurface density and roughness.

Sustainability of prevention practices at the workplace: safety, simplification, productivity and effectiveness.

PubMed

Messineo, A; Cattaruzza, M S; Prestigiacomo, C; Giordano, F; Marsella, L T

2017-01-01

Traditional full-time employment has evolved into various types of occupational situations, and, nowadays, new work organization strategies have been developed. Previously overlooked risk factors have emerged, such as traffic accidents while commuting or during work hours, poor work organization, and detrimental lifestyles (like alcohol and substance abuse, although recent statistics seem to show a declining trend for the latter). The global scenario shows greater attention to occupational risks, but also, to the reduced degree of protection. Moreover, the elevated costs, the unacceptably high fatal accident rates in some sectors, the complexity of the prevention systems, the lack of prevention training, the inadequate controls (despite the numerous independent supervisory bodies) and the obsolescence of certain precepts, call for a prompt review of the regulatory system. This is especially needed for general simplification, streamlining certification bodies and minimizing references to other provisions in the legislation that make it difficult for Italian and foreign workers to read and understand the rules "without legal interpreters". "New" occupational diseases and occupational risk factors have also been reported in addition to pollution. There are concerns for continued economic and social destabilization, unemployment, commuting, temporary and precarious contracts. All of these contribute to the lack of wellbeing in the working population. Thus, the timing, duration, and types of prevention training should be carefully assessed, making prevention more appealing by evaluating costs and benefits with a widespread use of indicators that make appropriate actions for health promotion "visible", thus encouraging awareness. Although reducing prevention is never justified, it should still be "sustainable" economically in order to avoid waste of resources. It is also essential to have laws which are easily and consistently interpreted and to work on the ethics of employers and employees to ensure that they conform to the standards of other European countries that currently operate with greater effectiveness and lower costs.

Getting By: Underuse of Interpreters by Resident Physicians

PubMed Central

Schenker, Yael; Curry, Leslie; Bradley, Elizabeth H.; Fernandez, Alicia

2008-01-01

Background Language barriers complicate physician–patient communication and adversely affect healthcare quality. Research suggests that physicians underuse interpreters despite evidence of benefits and even when services are readily available. The reasons underlying the underuse of interpreters are poorly understood. Objective To understand the decision-making process of resident physicians when communicating with patients with limited English proficiency (LEP). Design Qualitative study using in-depth interviews. Participants Internal medicine resident physicians ( = 20) from two urban teaching hospitals with excellent interpreter services. Approach An interview guide was used to explore decision making about interpreter use. Results Four recurrent themes emerged: 1) Resident physicians recognized that they underused professional interpreters, and described this phenomenon as “getting by;” 2) Resident physicians made decisions about interpreter use by weighing the perceived value of communication in clinical decision making against their own time constraints; 3) The decision to call an interpreter could be preempted by the convenience of using family members or the resident physician’s use of his/her own second language skills; 4) Resident physicians normalized the underuse of professional interpreters, despite recognition that patients with LEP are not receiving equal care. Conclusions Although previous research has identified time constraints and lack of availability of interpreters as reasons for their underuse, our data suggest that the reasons are far more complex. Residents at the study institutions with interpreters readily available found it easier to “get by” without an interpreter, despite misgivings about negative implications for quality of care. Findings suggest that increasing interpreter use will require interventions targeted at both individual physicians and the practice environment. PMID:19089503

Penultimate interpretation.

PubMed

Neuman, Yair

2010-10-01

Interpretation is at the center of psychoanalytic activity. However, interpretation is always challenged by that which is beyond our grasp, the 'dark matter' of our mind, what Bion describes as ' O'. O is one of the most central and difficult concepts in Bion's thought. In this paper, I explain the enigmatic nature of O as a high-dimensional mental space and point to the price one should pay for substituting the pre-symbolic lexicon of the emotion-laden and high-dimensional unconscious for a low-dimensional symbolic representation. This price is reification--objectifying lived experience and draining it of vitality and complexity. In order to address the difficulty of approaching O through symbolization, I introduce the term 'Penultimate Interpretation'--a form of interpretation that seeks 'loopholes' through which the analyst and the analysand may reciprocally save themselves from the curse of reification. Three guidelines for 'Penultimate Interpretation' are proposed and illustrated through an imaginary dialogue. Copyright © 2010 Institute of Psychoanalysis.

Communication and Decision-Making About End-of-Life Care in the Intensive Care Unit.

PubMed

Brooks, Laura Anne; Manias, Elizabeth; Nicholson, Patricia

2017-07-01

Clinicians in the intensive care unit commonly face decisions involving withholding or withdrawing life-sustaining therapy, which present many clinical and ethical challenges. Communication and shared decision-making are key aspects relating to the transition from active treatment to end-of-life care. To explore the experiences and perspectives of nurses and physicians when initiating end-of-life care in the intensive care unit. The study was conducted in a 24-bed intensive care unit in Melbourne, Australia. An interpretative, qualitative inquiry was used, with focus groups as the data collection method. Intensive care nurses and physicians were recruited to participate in a discipline-specific focus group. Focus group discussions were audio-recorded, transcribed, and subjected to thematic data analysis. Five focus groups were conducted; 17 nurses and 11 physicians participated. The key aspects discussed included communication and shared decision-making. Themes related to communication included the timing of end-of-life care discussions and conducting difficult conversations. Implementation and multidisciplinary acceptance of end-of-life care plans and collaborative decisions involving patients and families were themes related to shared decision-making. Effective communication and decision-making practices regarding initiating end-of-life care in the intensive care unit are important. Multidisciplinary implementation and acceptance of end-of-life care plans in the intensive care unit need improvement. Clear organizational processes that support the introduction of nurse and physician end-of-life care leaders are essential to optimize outcomes for patients, family members, and clinicians. ©2017 American Association of Critical-Care Nurses.

"A Scientist Has Many Things to Do:" EPO Strategies that Focus on the Processes of Science

NASA Astrophysics Data System (ADS)

Laursen, S. L.; Brickley, A. L.

2011-09-01

Scientists' effort in education and public outreach (EPO) is best invested in sharing their expertise on the nature and processes of science - the "understandings of science" that are emphasized in the National Science Education Standards, but that are difficult to teach and poorly supported by existing curricular materials. These understandings address the intellectual process of science - posing questions, gathering and interpreting evidence - and the social process of science as a human endeavor for building knowledge. We share several ways of incorporating concepts about the nature and processes of science into EP/O activities and making them focal points in their own right. Hands-on activities used at science festivals and in classrooms and professional development workshops illustrate key scientific thinking skills such as observing, classifying, making predictions, and drawing inferences. A more comprehensive approach is exemplified by Upward and Outward: Scientific Inquiry on the Tibetan Plateau, a 20-minute educational documentary film for school science classrooms and teacher professional development. The film portrays the intellectual and human processes of science through an inside view of a research project; classroom assessments offer evidence of its impact on students' ideas about these processes.

Between violation and competent care—Lived experiences of dependency on care in the ICU

PubMed Central

Lykkegaard, Kristina; Delmar, Charlotte

2015-01-01

This study explores the perceived meaning of dependency on care as experienced by intensive care patients. Research from non-intensive settings shows that dependency is often experienced negatively, but literature on the subject experienced by patients in the ICU is sparse. The study is based on in-depth qualitative semi-structured interviews of lived experience with three former patients admitted to an intensive care unit at a Danish university hospital. The in-depth interviews have been characterized as narratives. The main inspiration for the analysis method is Ricoeur's phenomenological hermeneutical interpretation theory. The study has found that dependency is experienced as difficult, and the relationship with the nurses seems to be ambivalent. The good relationship is experienced to make dependency easier, whereas negative experiences make it harder to cope with dependency. The participants deal with dependency by accepting negative experiences in gratitude for having recovered from critical illness. The findings might be influenced by studies being conducted in a western country setting where independence is valued. They can be used as means of reflection on nursing practice and matters such as communication and patient participation. PMID:25765881

Decision-making for destination therapy left ventricular assist devices: implications for caregivers.

PubMed

McIlvennan, Colleen K; Jones, Jacqueline; Allen, Larry A; Lindenfeld, JoAnn; Swetz, Keith M; Nowels, Carolyn; Matlock, Daniel D

2015-03-01

Implanting centers often require the identification of a dedicated caregiver before destination therapy left ventricular assist device (DT LVAD) implantation; however, the caregiver experience surrounding this difficult decision is relatively unexplored. From October 2012 through July 2013, we conducted semistructured, in-depth interviews with caregivers of patients considering DT LVAD. Data were analyzed using a mixed inductive and deductive approach. We interviewed 17 caregivers: 10 caregivers of patients living with DT LVAD, 6 caregivers of patients who had died with DT LVAD, and 1 caregiver of a patient who had declined DT LVAD. The themes identified, which could also be considered dialectical tensions, are broadly interpreted under 3 domains mapping to decision context, process, and outcome: (1) the stark decision context, with tension between hope and reality; (2) the challenging decision process, with tension between wanting loved ones to live and wanting to respect loved ones' wishes; and (3) the downstream decision outcome, with tension between gratitude and burden. Decision-making surrounding DT LVAD should incorporate decision support for patients and caregivers. This should include a focus on caregiver burden and the predictable tensions that caregivers experience. © 2015 American Heart Association, Inc.

Process perspective on image quality evaluation

NASA Astrophysics Data System (ADS)

Leisti, Tuomas; Halonen, Raisa; Kokkonen, Anna; Weckman, Hanna; Mettänen, Marja; Lensu, Lasse; Ritala, Risto; Oittinen, Pirkko; Nyman, Göte

2008-01-01

The psychological complexity of multivariate image quality evaluation makes it difficult to develop general image quality metrics. Quality evaluation includes several mental processes and ignoring these processes and the use of a few test images can lead to biased results. By using a qualitative/quantitative (Interpretation Based Quality, IBQ) methodology, we examined the process of pair-wise comparison in a setting, where the quality of the images printed by laser printer on different paper grades was evaluated. Test image consisted of a picture of a table covered with several objects. Three other images were also used, photographs of a woman, cityscape and countryside. In addition to the pair-wise comparisons, observers (N=10) were interviewed about the subjective quality attributes they used in making their quality decisions. An examination of the individual pair-wise comparisons revealed serious inconsistencies in observers' evaluations on the test image content, but not on other contexts. The qualitative analysis showed that this inconsistency was due to the observers' focus of attention. The lack of easily recognizable context in the test image may have contributed to this inconsistency. To obtain reliable knowledge of the effect of image context or attention on subjective image quality, a qualitative methodology is needed.

Interpreting anomalously low voltage noise in two-channel measurement systems.

PubMed

Ivanov, Eugene N; Walls, Fred L

2002-01-01

In this work we 1) analyze and give a theoretical explanation for the anomalously low cross-spectral density of voltage fluctuations that is observed when two thermal noise sources with matched intensities are coupled to the inputs of two-channel phase modulation (PM) or amplitude modulation (AM) noise measurement systems (NMS), 2) empirically evaluate spectral resolutions of different types of measurement systems, and 3) discuss noise measurement techniques involving cross-correlation signal processing. Our work shows that the statistical uncertainty, which sets the ultimate spectral resolution in the thermal noise limited regime, is approximately the same for both systems. However, in practical terms, the non-stationary nature of the noise, the temporal separation of calibration and measurement, and the difficulty of reproducing the calibrations for two measurements make it extremely difficult to resolve noise that is more than 10 dB below the noise floor in a single channel NMS. In a two-channel NMS, however, the calibrations of the two channels are carried out simultaneously, and one can take full advantage of a large number of averages and make reproducible noise measurements with resolution 10 dB below the noise floor of a single channel NMS.

Good practice for conducting and reporting MEG research

PubMed Central

Gross, Joachim; Baillet, Sylvain; Barnes, Gareth R.; Henson, Richard N.; Hillebrand, Arjan; Jensen, Ole; Jerbi, Karim; Litvak, Vladimir; Maess, Burkhard; Oostenveld, Robert; Parkkonen, Lauri; Taylor, Jason R.; van Wassenhove, Virginie; Wibral, Michael; Schoffelen, Jan-Mathijs

2013-01-01

Magnetoencephalographic (MEG) recordings are a rich source of information about the neural dynamics underlying cognitive processes in the brain, with excellent temporal and good spatial resolution. In recent years there have been considerable advances in MEG hardware developments and methods. Sophisticated analysis techniques are now routinely applied and continuously improved, leading to fascinating insights into the intricate dynamics of neural processes. However, the rapidly increasing level of complexity of the different steps in a MEG study make it difficult for novices, and sometimes even for experts, to stay aware of possible limitations and caveats. Furthermore, the complexity of MEG data acquisition and data analysis requires special attention when describing MEG studies in publications, in order to facilitate interpretation and reproduction of the results. This manuscript aims at making recommendations for a number of important data acquisition and data analysis steps and suggests details that should be specified in manuscripts reporting MEG studies. These recommendations will hopefully serve as guidelines that help to strengthen the position of the MEG research community within the field of neuroscience, and may foster discussion in order to further enhance the quality and impact of MEG research. PMID:23046981

Context in Generalized Conversational Implicatures: The Case of Some

PubMed Central

Dupuy, Ludivine E.; Van der Henst, Jean-Baptiste; Cheylus, Anne; Reboul, Anne C.

2016-01-01

There is now general agreement about the optionality of scalar implicatures: the pragmatic interpretation will be accessed depending on the context relative to which the utterance is interpreted. The question, then, is what makes a context upper- (vs. lower-) bounding. Neo-Gricean accounts should predict that contexts including factual information will enhance the rate of pragmatic interpretations. Post-Gricean accounts should predict that contexts including psychological attributions will enhance the rate of pragmatic interpretations. We tested two factors using the quantifier scale : (1) the existence of factual information that facilitates the computation of pragmatic interpretations in the context (here, the cardinality of the domain of quantification) and (2) the fact that the context makes the difference between the semantic and the pragmatic interpretations of the target sentence relevant, involving psychological attributions to the speaker (here a question using all). We did three experiments, all of which suggest that while cardinality information may be necessary to the computation of the pragmatic interpretation, it plays a minor role in triggering it; highlighting the contrast between the pragmatic and the semantic interpretations, while it is not necessary to the computation of the pragmatic interpretation, strongly mandates a pragmatic interpretation. These results favor Sperber and Wilson's (1995) post-Gricean account over Chierchia's (2013) neo-Gricean account. Overall, this suggests that highlighting the relevance of the pragmatic vs. semantic interpretations of the target sentence makes a context upper-bounding. Additionally, the results give a small advantage to the post-Gricean account. PMID:27047413

Are Lung Imaging Reporting and Data System Categories Clear to Radiologists? A Survey of the Korean Society of Thoracic Radiology Members on Ten Difficult-to-Classify Scenarios.

PubMed

Han, Dae Hee; Goo, Jin Mo; Chong, Semin; Ahn, Myeong Im

2017-01-01

To evaluate possible variability in chest radiologists' interpretations of the Lung Imaging Reporting and Data System (Lung-RADS) on difficult-to-classify scenarios. Ten scenarios of difficult-to-classify imaginary lung nodules were prepared as an online survey that targeted Korean Society of Thoracic Radiology members. In each question, a description was provided of the size, consistency, and interval change (new or growing) of a lung nodule observed using annual repeat computed tomography, and the respondent was instructed to choose one answer from five choices: category 2, 3, 4A, or 4B, or "un-categorizable." Consensus answers were established by members of the Korean Imaging Study Group for Lung Cancer. Of the 420 answers from 42 respondents (excluding multiple submissions), 310 (73.8%) agreed with the consensus answers; eleven (26.2%) respondents agreed with the consensus answers to six or fewer questions. Assigning the imaginary nodules to categories higher than the consensus answer was more frequent (16.0%) than assigning them to lower categories (5.5%), and the agreement rate was below 50% for two scenarios. When given difficult-to-classify scenarios, chest radiologists showed large variability in their interpretations of the Lung-RADS categories, with high frequencies of disagreement in some specific scenarios.

Evidence Relating Subjective Contours and Interpretations Involving Occlusion.

DTIC Science & Technology

1981-06-01

This article describes a patient with visual agnosia who is both unable to make the usual occlusion interpretations and is unable to see subjective...article describes a patient with visual agnosia who is both unable to make the usual occlusion interpretions and is unable to see subjective contours...Dr. Howard Gardner for providing access to the facilities at Boston Veterans Administration Hospital for examination of the agnosia patient J.R. Also

Diagnosis of Osteoporosis.

ERIC Educational Resources Information Center

Wahner, H. W.

1987-01-01

Early recognition of osteoporosis is difficult because symptoms are lacking and there are no distinct, readily accessible diagnostic features. This article reviews the standard approach, radiographic and laboratory diagnosis, bone mass measurement techniques, and interpretation of bone mineral data. (MT)

The role of the bioethicist in family meetings about end of life care.

PubMed

Watkins, Liza T; Sacajiu, Galit; Karasz, Alison

2007-12-01

There has been little study of the content of bioethicists' communication during family meeting consultations about end of life care. In the literature, two roles for bioethicists are usually described: the "consultant" role, in which bioethicists define and support ethical principles such as those enshrined in the "rational choice" model; and the "mediator" role, which focuses on the enhancement of communication in order to reduce conflict. In this study, we use observational data to explore how bioethicists support the practice of decision making during family meetings about end of life care. In a study conducted in the Bronx, New York, USA, researchers observed and recorded 24 decision-making meetings between hospital staff and family members of elderly patients identified as being in the last stages of illness, who were unable or unwilling to make the decision for themselves. Bioethics consultants were present during five of those meetings. Although bioethicists referred to the "rational choice" decision-making hierarchy, we did not see the systematic exploration described in the literature. Rather, our data show that bioethicists tended to employ elements of the rational model at particular turning points in the decision-making process in order to achieve pragmatic goals. As mediators, bioethicists worked to create consensus between family and staff and provided invaluable sympathy and comfort to distressed family members. We also found evidence of a context-dependent approach to mediation, with bioethicists' contributions generally supporting staff views about end of life care. Bioethicists' called to consult on family meetings about end of life care do not appear to adhere to a strict interpretation of the official guidelines. In order to negotiate the difficult terrain of end of life decision making, our data show that bioethicists often add a third role, "persuader", to official roles of "consultant" and "mediator".

Genotype × Environment Interaction in Smoking Behaviors: A Systematic Review.

PubMed

Do, Elizabeth K; Maes, Hermine H

2017-04-01

There has been rapid growth in research exploring gene-environment interaction (G×E) contributing to smoking behaviors. Yet, no systematic review exists to date. This article aims to review evidence on the contribution of G×E to the risk of smoking. Through a search of electronic databases (ie, Google Scholar, PubMed, ScienceDirect, and Elsevier) up until May 2014, 16 studies of G×E focused on smoking behaviors were identified. These studies were compared in terms of: research design and sample studied, measure of smoking behavior and environments used, genes explored, and G×E in relation to these factors. Thirteen of 16 studies (81.2%) found at least one significant G×E association. Wide variation in analytic methods was found across studies, especially with respect to the phenotypes of interest, environmental measures used, and tests conducted to estimate G×E. Heterogeneity across studies made it difficult to compare findings and evaluate the strength of evidence for G×E. G×E research on smoking contains studies that are methodologically different, making it difficult to assess the current state of the evidence. To decrease heterogeneity, we offer recommendations related to: (1) choice of measurement for environmental variables, (2) testing and reporting of main and interaction effects, (3) treatment of covariates, (4) reporting gene-environment correlation, and (5) conducting sensitivity analyses and checking for scaling artifacts. Continued study is needed to identify mechanisms by which genes and environmental factors combine to influence smoking behaviors. No comprehensive review of G×E studies of smoking behavior has previously been published. The present article seeks to fill this gap by providing a comprehensive review of: how G×E has been defined, how twin and molecular genetic methodologies have been used to test for G×E, and which genes and environmental factors are associated with smoking behaviors. Variations in methodological approaches make it difficult to interpret and summarize findings, so recommendations for future research are provided as a means to more easily compare and replicate findings across studies. © The Author 2016. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Bridging the gap between evidence and policy for infectious diseases: How models can aid public health decision-making.

PubMed

Knight, Gwenan M; Dharan, Nila J; Fox, Gregory J; Stennis, Natalie; Zwerling, Alice; Khurana, Renuka; Dowdy, David W

2016-01-01

The dominant approach to decision-making in public health policy for infectious diseases relies heavily on expert opinion, which often applies empirical evidence to policy questions in a manner that is neither systematic nor transparent. Although systematic reviews are frequently commissioned to inform specific components of policy (such as efficacy), the same process is rarely applied to the full decision-making process. Mathematical models provide a mechanism through which empirical evidence can be methodically and transparently integrated to address such questions. However, such models are often considered difficult to interpret. In addition, models provide estimates that need to be iteratively re-evaluated as new data or considerations arise. Using the case study of a novel diagnostic for tuberculosis, a framework for improved collaboration between public health decision-makers and mathematical modellers that could lead to more transparent and evidence-driven policy decisions for infectious diseases in the future is proposed. The framework proposes that policymakers should establish long-term collaborations with modellers to address key questions, and that modellers should strive to provide clear explanations of the uncertainty of model structure and outputs. Doing so will improve the applicability of models and clarify their limitations when used to inform real-world public health policy decisions. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

Mapping and monitoring changes in vegetation communities of Jasper Ridge, CA, using spectral fractions derived from AVIRIS images

NASA Technical Reports Server (NTRS)

Sabol, Donald E., Jr.; Roberts, Dar A.; Adams, John B.; Smith, Milton O.

1993-01-01

An important application of remote sensing is to map and monitor changes over large areas of the land surface. This is particularly significant with the current interest in monitoring vegetation communities. Most of traditional methods for mapping different types of plant communities are based upon statistical classification techniques (i.e., parallel piped, nearest-neighbor, etc.) applied to uncalibrated multispectral data. Classes from these techniques are typically difficult to interpret (particularly to a field ecologist/botanist). Also, classes derived for one image can be very different from those derived from another image of the same area, making interpretation of observed temporal changes nearly impossible. More recently, neural networks have been applied to classification. Neural network classification, based upon spectral matching, is weak in dealing with spectral mixtures (a condition prevalent in images of natural surfaces). Another approach to mapping vegetation communities is based on spectral mixture analysis, which can provide a consistent framework for image interpretation. Roberts et al. (1990) mapped vegetation using the band residuals from a simple mixing model (the same spectral endmembers applied to all image pixels). Sabol et al. (1992b) and Roberts et al. (1992) used different methods to apply the most appropriate spectral endmembers to each image pixel, thereby allowing mapping of vegetation based upon the the different endmember spectra. In this paper, we describe a new approach to classification of vegetation communities based upon the spectra fractions derived from spectral mixture analysis. This approach was applied to three 1992 AVIRIS images of Jasper Ridge, California to observe seasonal changes in surface composition.

Ordo ab Chao: framework for an integrated disease report.

PubMed

de Baca, Monica E; Arnaout, Ramy; Brodsky, Victor; Birdsong, George G

2015-02-01

The volume of information that must be assimilated to appropriately manage patients with complex or chronic disease can make this task difficult because of the number of data points, their variable temporal availability, and the fact that they may reside in different systems or even institutions. OBJECTIVE .- To outline a framework for building an integrated disease report (IDR) that takes advantage of the capabilities of electronic reporting to create a single, succinct, interpretative report comprising all disease pertinent data. Disease pertinent data of an IDR include pathology results, laboratory and radiology data, pathologic correlations, risk profiles, and therapeutic implications. We used cancer herein as a representative process for proposing what is, to our knowledge, the first example of standardized guidelines for such a report. The IDR was defined as a modular, dynamic, electronic summary of the most current state of a patient in regard to a particular illness such as lung cancer or diabetes, which includes all information relevant for patient management. We propose the following 11 core data concepts that an IDR should include: patient identification; patient demographics; disease, diagnosis, and prognosis; tumor board dispositions and decisions; graphic timeline; preresection workup and therapy; resection workup; interpretative comment summarizing pertinent findings; biobanking data; postresection workup; and disease and patient status at follow-up. A well-executed IDR should improve patient care and efficiency for health care team members. It would demonstrate the added value of pathology interpretation and likely contribute to a reduction in errors and improved patient safety by decreasing the risk that important data will be overlooked.

Using bioimpedance spectroscopy parameters as real-time feedback during tDCS.

PubMed

Nejadgholi, Isar; Caytak, Herschel; Bolic, Miodrag

2016-08-01

An exploratory analysis is carried out to investigate the feasibility of using BioImpedance Spectroscopy (BIS) parameters, measured on scalp, as real-time feedback during Transcranial Direct Current Stimulation (tDCS). TDCS is shown to be a potential treatment for neurological disorders. However, this technique is not considered as a reliable clinical treatment, due to the lack of a measurable indicator of treatment efficacy. Although the voltage that is applied on the head is very simple to measure during a tDCS session, changes of voltage are difficult to interpret in terms of variables that affect clinical outcome. BIS parameters are considered as potential feedback parameters, because: 1) they are shown to be associated with the DC voltage applied on the head, 2) they are interpretable in terms of conductive and capacitive properties of head tissues, 3) physical interpretation of BIS measurements makes them prone to be adjusted by clinically controllable variables, 4) BIS parameters are measurable in a cost-effective and safe way and do not interfere with DC stimulation. This research indicates that a quadratic regression model can predict the DC voltage between anode and cathode based on parameters extracted from BIS measurements. These parameters are extracted by fitting the measured BIS spectra to an equivalent electrical circuit model. The effect of clinical tDCS variables on BIS parameters needs to be investigated in future works. This work suggests that BIS is a potential method to be used for monitoring a tDCS session in order to adjust, tailor, or personalize tDCS treatment protocols.

Lupus anticoagulant: a multicenter study for a standardized and harmonized reporting.

PubMed

Poz, Alessandra; Pradella, Paola; Azzarini, Gabriella; Santarossa, Liliana; Bardin, Cristina; Zardo, Lorena; Giacomello, Roberta

2016-03-01

Laboratory assessment of Lupus anticoagulant (LAC) is very challenging because of inter and intralaboratory variability, which makes it difficult to standardize and harmonize results expression. Five hospital laboratories in North-eastern Italy shared their efforts and their experience in a cross-laboratory study, conducting the diagnostic process as homogeneously as possible and providing a better interpretation for LAC positivity. Hundred normal samples from healthy subjects (20 from each center) were processed to confirm negative upper limits and calculate positivity cutoffs of LAC integrated assays, that is dilute Russell's viper venom time (dRVVT) and silica clotting time (SCT). Moreover, 311 samples previously diagnosed by the laboratories as positive for LAC were analyzed to characterize different positivity levels for each assay. As far as the analysis of healthy subjects is concerned, negative upper limits are set at 1.17 and 1.19 for dRVVT and SCT screen ratio, respectively. Positivity cutoffs are set at 1.20 for dRVVT and 1.23 for SCT, expressed as Test Ratio calculated on screen and confirm integrated tests. Positive results for each integrated assay are subsequently divided into three subgroups: weak, moderate and strong; the results obtained are presented as a score proposal that can provide LAC interpretation. The combined use of both dRVVT and SCT assays and the definition of different positivity levels may lead to clearer, more objective LAC reporting. An interpretative table for LAC-proposed score provides LAC-positive results and it is now adopted by all centers involved in the study.

Lithologic Coring in the Lower Anacostia Tidal Watershed, Washington, D.C., July 2002

USGS Publications Warehouse

Tenbus, Frederick J.

2003-01-01

Little is known about the volumetric flux of ground water to the lower tidal Anacostia River, or whether ground-water flow is an important component of the contaminant load in this part of the Anacostia River. The watershed is in the eastern part of Washington, D.C., and has been subjected to over 200 years of urbanization and modifications of the river channel and nearby land areas. These anthropogenic factors, along with tidal fluctuations in the river, make ground-water data collection and interpretations difficult. The U.S. Geological Survey is cooperating with the District of Columbia Department of Health, Environmental Health Administration, Bureau of Environmental Quality, Water Quality Division, in a study to assess nonpoint-source pollution from ground water into the lower tidal Anacostia River. Lithologic cores from drilling activities conducted during July 2002 in the study area have been interpreted in the context of geologic and hydrogeologic information from previous studies in the lower Anacostia tidal watershed. These interpretations can help achieve the overall project goals of characterizing ground-water flow and contaminant load in the study area. Hydrostratigraphic units encountered during drilling generally consisted of late Pleistocene to Holocene fluvial deposits overlying Cretaceous fluvial/deltaic deposits. Cores collected in Beaverdam Creek and the Anacostia River indicated high- and low-energy environments of deposition, respectively. Two cores collected near the river showed different types of anthropogenic fill underlain by low-energy deposits, which were in turn underlain by sand and gravel. A third core collected near the river consisted primarily of sand and gravel with no artificial fill.

More superconductivity questions than answers.

PubMed

Robinson, A L

1987-07-17

Although making liquid nitrogen-temperature superconductors is easy enough that high school science projects already feature them, researchers still have little idea how the new ceramic oxides work and therefore little guidance for improving them. At the International Workshop on Novel Mechanisms of Superconductivity, held from 22 to 26 June in Berkeley, California, theorists reviewed a host of competing explanations of how these materials come by their remarkable properties, but they could not, get far in sifting through the candidates for the best one. One cause of the unsettled situation is that theorists have not yet pushed their models far enough to make many specific predictions about physical properties and therefore to provide a reason to choose one theory over another. But experimental data for comparison with theory are lacking, too. For example, experimentalists are just now succeeding in being able to grow single crystals and thin films of the ceramic oxide superconductors, whose properties were shown at the workshop to be highly anisotropic. Measurements already made on the polycrystalline sintered material available up to now are difficult to interpret and therefore need to be repeated on good-quality crystals and films, where the variation of properties with crystallographic orientation can be mapped out. Given the high level of Japanese activity in the field, it was surprising that no researchers from industrial laboratories in Japan presented their findings at the workshop. In the light of a budding international competition in commercializing superconductors, some American scientists interpreted the absence as an attempt to protect proprietary advances. A more pleasant surprise was the attendance of a delegation of six Soviet scientists, although one of the fathers of superconductivity theory, Vitaly Ginzburg of the P.N.Lebedev Institute of Physics in Moscow, who was expected, did not come.

Emerging communications technologies for outer-planet exploration

NASA Technical Reports Server (NTRS)

Stelzried, C.; Lesh, J.

2001-01-01

Communication over long free space distances is extremely difficult due to the inverse squared propagation losses associated with link distance. That makes communications particularly difficult from outer planet destinations.

What do large scale studies of medication in schizophrenia add to our management strategies?

PubMed

Agius, Mark; Davis, Abigail; Gilhooley, Michael; Chapman, Shelley; Zaman, Rashid

2010-06-01

A number of large naturalistic trials have reported in recent years comparing second generation antipsychotic drugs with their predecessors. The conclusions they draw have rightly sparked much debate, but are these studies truly comparable? If not, which of them are most methodologically robust and are these the studies most suitable as a foundation for clinical care guidelines with a strong evidence base. We aimed to conduct a review of the current literature to establish the appropriateness of several recent major clinical studies being used as the basis for clinical guidelines. A literature search using the PUBMED database was carried out. Five major studies comparing antipsychotic efficacy were selected as possible candidates and subjected to further analysis. The studies were: * CUTLASS (Cost Utility of the Latest Antipsychotic Drugs in Schizophrenia study); * CATIE (Clinical Antipsychotic Trials of Intervention Effectiveness study); * SOHO (Schizophrenia outpatients Health Outcomes study); * CAFE (Comparison of Atypicals in First Episode study); * EUFEST (European First Episode Schizophrenia Trial). The trials: * CAFE - the trial, although well randomised and blinded, uses discontinuation as a primary endpoint - this is hard to draw conclusions from: patients may discontinue due to side effects, due to lack of efficacy or with against medical advice for a multitude of reasons. As a secondary endpoint, the study does make use of a PANSS scoring system to measure efficacy, adding some weight to the conclusion that olanzapine, quetiaine and risperidone in early psychosis patients have equivalent efficacies. * CATIE - This trial was a comparative study, and so lacked a control arm and used discontinuation of medication an inverse measure of efficacy - an easily quantifiable event, but making for difficult interpretation. However most criticism has been directed at the unusually low (quitiapine, ziprasidone) and high (olanzapine and perphenazine) doses of drug used, which were reflected in their differing rates of efficacy. * CUtLASS This trial allows for less generalisation of its findings to the general population as it makes use a specific sub-population (those switching from one medication to another after a period of treatment). Also some patients were prescribed oral medications and some depot injections - making comparisons difficult due to possible differences in compliance. * EUFEST This trial makes use of discontinuation as an endpoint with the weaknesses we have described. Treatment of first episodes of psychosis is shown to be feasible, but it could not suggest if haloperidol or second generation drugs may be more efficacious. * SOHO - This trial hindered by the observational design of the study and small numbers reaching the primary end point (4%) caution should be exercised in the conclusion that olanzapine is superior to risperidone, quetiapine or typical antipsychotics. There is much information useful for clinical practice to be gathered from the results of these major studies, however, interpretation is hampered by both variations and weakness in study design. On balance it does appear that different antipsychotics possess differing efficacy, but also of relevance to the development of sound clinical guidelines is their differing side effects profile.

The relationship between symbolic interactionism and interpretive description.

PubMed

Oliver, Carolyn

2012-03-01

In this article I explore the relationship between symbolic interactionist theory and interpretive description methodology. The two are highly compatible, making symbolic interactionism an excellent theoretical framework for interpretive description studies. The pragmatism underlying interpretive description supports locating the methodology within this cross-disciplinary theory to make it more attractive to nonnursing researchers and expand its potential to address practice problems across the applied disciplines. The theory and method are so compatible that symbolic interactionism appears to be part of interpretive description's epistemological foundations. Interpretive description's theoretical roots have, to date, been identified only very generally in interpretivism and the philosophy of nursing. A more detailed examination of its symbolic interactionist heritage furthers the contextualization or forestructuring of the methodology to meet one of its own requirements for credibility.

Interpretations of Quantum Theory in the Light of Modern Cosmology

NASA Astrophysics Data System (ADS)

Castagnino, Mario; Fortin, Sebastian; Laura, Roberto; Sudarsky, Daniel

2017-11-01

The difficult issues related to the interpretation of quantum mechanics and, in particular, the "measurement problem" are revisited using as motivation the process of generation of structure from quantum fluctuations in inflationary cosmology. The unessential mathematical complexity of the particular problem is bypassed, facilitating the discussion of the conceptual issues, by considering, within the paradigm set up by the cosmological problem, another problem where symmetry serves as a focal point: a simplified version of Mott's problem.

Improving the effectiveness of ecological site descriptions: General state-and-transition models and the Ecosystem Dynamics Interpretive Tool (EDIT)

USGS Publications Warehouse

Bestelmeyer, Brandon T.; Williamson, Jeb C.; Talbot, Curtis J.; Cates, Greg W.; Duniway, Michael C.; Brown, Joel R.

2016-01-01

State-and-transition models (STMs) are useful tools for management, but they can be difficult to use and have limited content.STMs created for groups of related ecological sites could simplify and improve their utility. The amount of information linked to models can be increased using tables that communicate management interpretations and important within-group variability.We created a new web-based information system (the Ecosystem Dynamics Interpretive Tool) to house STMs, associated tabular information, and other ecological site data and descriptors.Fewer, more informative, better organized, and easily accessible STMs should increase the accessibility of science information.

Measuring pretest-posttest change with a Rasch Rating Scale Model.

PubMed

Wolfe, E W; Chiu, C W

1999-01-01

When measures are taken on the same individual over time, it is difficult to determine whether observed differences are the result of changes in the person or changes in other facets of the measurement situation (e.g., interpretation of items or use of rating scale). This paper describes a method for disentangling changes in persons from changes in the interpretation of Likert-type questionnaire items and the use of rating scales (Wright, 1996a). The procedure relies on anchoring strategies to create a common frame of reference for interpreting measures that are taken at different times and provides a detailed illustration of how to implement these procedures using FACETS.

Assessing cancer drugs for reimbursement: methodology, relationship between effect size and medical need.

PubMed

de Sahb-Berkovitch, Rima; Woronoff-Lemsi, Marie-Christine; Molimard, Mathieu

2010-01-01

Reimbursement is assessed by the Transparency Commission from the Health Authority (HAS) using a medical benefit (SMR) score that gives access to reimbursement, an "improvement of medical service rendered" (ASMR) that determines the added therapeutic value, and the target population. Assessing cancer drugs for reimbursement raises the same issues as other therapeutic classes, with some key differences. Overall survival (OS) is considered by the Transparency Commission as the endpoint for assessing clinical benefit, and yet it is not an applicable primary endpoint in all types of cancer. Later lines of treatment, particularly during the development process, may make it difficult to interpret OS as the primary endpoint. Therefore, progression-free survival (PFS) for metastatic situations and disease-free survival (DFS) in adjuvant situations are wholly relevant endpoints for decisions on the reimbursement of a new cancer drug. Effect size is assessed using actuarial survival curves of the product versus the comparator, and it is difficult to summarise them into one single parameter. Results are generally interpreted based on median survival, which is fragmented because it only measures one point of the curve. The hazard ratio measures the effect of treatment throughout the duration of survival and is therefore more comprehensive in quantifying clinical benefit. Determining an effect size threshold for granting reimbursement is difficult given the diversity of cancer settings and the level of medical need, which influences assessment of the clinical relevance of the observed difference. Rapid progress in comparators (700 molecules in development) and the identification of predictive factors of efficacy (biomarkers, histology, etc.) during development may lead to different ASMR scores per population, or to the restriction of the target population to a subgroup of the marketing authorisation (MA) population in which the expected effect size is greater. To address these issues, the roundtable recommends the possibility of early scientific opinions by the office of the Transparency Commission in order to discuss comparators and the relevance of responder subgroups. It also recommends the possibility of granting a temporary ASMR, on condition of subsequent confirmation by production of data, when reimbursement appears justified in a subpopulation of the MA for which only subgroup analysis is available. © 2010 Société Française de Pharmacologie et de Thérapeutique.

Understanding and Interpreting Career Decision-Making Difficulties

ERIC Educational Resources Information Center

Amir, Tamar; Gati, Itamar; Kleiman, Tali

2008-01-01

This research develops and tests a procedure for interpreting individuals' responses in multiscale career assessments, using the Career Decision-Making Difficulties Questionnaire (CDDQ). In Study 1, criteria for ascertaining the credibility of responses were developed, based on the judgments of 39 career-counseling experts. In Study 2, the…

Ship detection leveraging deep neural networks in WorldView-2 images

NASA Astrophysics Data System (ADS)

Yamamoto, T.; Kazama, Y.

2017-10-01

Interpretation of high-resolution satellite images has been so difficult that skilled interpreters must have checked the satellite images manually because of the following issues. One is the requirement of the high detection accuracy rate. The other is the variety of the target, taking ships for example, there are many kinds of ships, such as boat, cruise ship, cargo ship, aircraft carrier, and so on. Furthermore, there are similar appearance objects throughout the image; therefore, it is often difficult even for the skilled interpreters to distinguish what object the pixels really compose. In this paper, we explore the feasibility of object extraction leveraging deep learning with high-resolution satellite images, especially focusing on ship detection. We calculated the detection accuracy using the WorldView-2 images. First, we collected the training images labelled as "ship" and "not ship". After preparing the training data, we defined the deep neural network model to judge whether ships are existing or not, and trained them with about 50,000 training images for each label. Subsequently, we scanned the evaluation image with different resolution windows and extracted the "ship" images. Experimental result shows the effectiveness of the deep learning based object detection.

Are Africans, Europeans, and Asians Different "Races"? A Guided-Inquiry Lab for Introducing Undergraduate Students to Genetic Diversity and Preparing Them to Study Natural Selection

ERIC Educational Resources Information Center

Kalinowski, Steven T.; Andrews, Tessa M.; Leonard, Mary J.; Snodgrass, Meagan

2012-01-01

Many students do not recognize that individual organisms within populations vary, and this may make it difficult for them to recognize the essential role variation plays in natural selection. Also, many students have weak scientific reasoning skills, and this makes it difficult for them to recognize misconceptions they might have. This paper…

An Interpretative Phenomenological Analysis of Sense-Making by Department of Defense Employees

ERIC Educational Resources Information Center

Harrison, John L., Sr.

2011-01-01

The purpose of this qualitative, phenomenological study was to explore the perceptions and lived experiences of Department of Defense (DOD) civilian employees to identify how their personal sense-making affects their coaching of adult students. The author used an interpretative phenomenological analysis (IPA) method involving personal interviews…

Infants and Toddlers as Members, Makers, Interpreters: A Philosophical Journey.

ERIC Educational Resources Information Center

Handler, June Moss

This book explores how young children, within their cultural imperatives, struggle to discover who they are as cultural "members" interacting with others, as "makers" trying out and creating, and as "interpreters" making meaning and making new connections. Chapters in Part 1 emphasize the significance of a…

Teachers' Perception, Interpretation, and Decision-Making: A Systematic Review of Empirical Mathematics Education Research

ERIC Educational Resources Information Center

Stahnke, Rebekka; Schueler, Sven; Roesken-Winter, Bettina

2016-01-01

Research in mathematics education has investigated teachers' professional knowledge in depth, comprising two different approaches: a cognitive and a situated perspective. Linking these two perspectives leads to addressing situation-specific skills such as perception, interpretation and decision-making, indicative of revealing a teacher's knowledge…

Making Pedagogical Adaptability Less Obvious

ERIC Educational Resources Information Center

Vagle, Mark D.

2016-01-01

In this article, I try to make pedagogical adaptability a bit less obvious. In particular, I use some post-structural philosophical ideas and some concepts at the intersections of social class and race to re-interpret Dylan Wiliam's conception of formative assessment. I suggest that this interpretation can provide opportunities to resist the urge…

A review of computer aided interpretation technology for the evaluation of radiographs of aluminum welds

NASA Technical Reports Server (NTRS)

Lloyd, J. F., Sr.

1987-01-01

Industrial radiography is a well established, reliable means of providing nondestructive structural integrity information. The majority of industrial radiographs are interpreted by trained human eyes using transmitted light and various visual aids. Hundreds of miles of radiographic information are evaluated, documented and archived annually. In many instances, there are serious considerations in terms of interpreter fatigue, subjectivity and limited archival space. Quite often it is difficult to quickly retrieve radiographic information for further analysis or investigation. Methods of improving the quality and efficiency of the radiographic process are being explored, developed and incorporated whenever feasible. High resolution cameras, digital image processing, and mass digital data storage offer interesting possibilities for improving the industrial radiographic process. A review is presented of computer aided radiographic interpretation technology in terms of how it could be used to enhance the radiographic interpretation process in evaluating radiographs of aluminum welds.

ASB Clinical Biomechanics Award Paper 2010: Virtual Pre-Operative Reconstruction Planning for Comminuted Articular Fractures

PubMed Central

Thomas, Thaddeus P.; Anderson, Donald D.; Willis, Andrew R.; Liu, Pengcheng; Marsh, J. Lawrence; Brown, Thomas D.

2010-01-01

Background Highly comminuted intra-articular fractures are complex and difficult injuries to treat. Once emergent care is rendered, the definitive treatment objective is to restore the original anatomy while minimizing surgically induced trauma. Operations that use limited or percutaneous approaches help preserve tissue vitality, but reduced visibility makes reconstruction more difficult. A pre-operative plan of how comminuted fragments would best be re-positioned to restore anatomy helps in executing a successful reduction. Methods In this study, methods for virtually reconstructing a tibial plafond fracture were developed and applied to clinical cases. Building upon previous benchtop work, novel image analysis techniques and puzzle solving algorithms were developed for clinical application. Specialty image analysis tools were used to segment the fracture fragment geometries from CT data. The original anatomy was then restored by matching fragment native (periosteal and subchondral) bone surfaces to an intact template, generated from the uninjured contralateral limb. Findings Virtual reconstructions obtained for ten tibial plafond fracture cases had average alignment errors of 0.39 (0.5 standard deviation) mm. In addition to precise reduction planning, 3D puzzle solutions can help identify articular deformities and bone loss. Interpretation The results from this study indicate that 3D puzzle solving provides a powerful new tool for planning the surgical reconstruction of comminuted articular fractures. PMID:21215501

Column Experiments to Interpret Weathering in Columbia Hills

NASA Technical Reports Server (NTRS)

Hausrath, E. M.; Morris, R.V.; Ming, D.W.; Golden, D.C.; Galindo, C.; Sutter, B.

2009-01-01

Phosphate mobility has been postulated as an indicator of early aqueous activity on Mars. In addition, rock surfaces analyzed by the Mars Exploration Rover Spirit are consistent with the loss of a phosphate- containing mineral To interpret phosphate alteration behavior on Mars, we performed column dissolution experiments leaching the primary phases Durango fluorapatite, San Carlos olivine, and basalt glass (Stapafjell Volcano, courtesy of S. Gislason, University of Iceland) [3,4]) with acidic solutions. These phases were chosen to represent quickly dissolving phases likely present in Columbia Hills. Column dissolution experiments are closer to natural dissolution conditions than batch experiments, although they can be difficult to interpret. Acidic solutions were used because the leached layers on the surfaces of these rocks have been interpreted as resulting from acid solutions [5].

Notation system and overlay diagrams for the analysis of paced electrocardiograms.

PubMed

Bernstein, A D; Parsonnet, V

1983-01-01

With the advent of adaptive dual-chamber pacing, the interaction between the pacemaker and the heart is becoming increasingly complex and the interpretation of paced electrocardiograms more difficult. We have developed a set of notation conventions for use in teaching and rhythm-strip analysis. Easily-drawn symbols delineate successful, unsuccessful, and inhibited pacing and sensing events as well as refractory and blanking periods. Another application is to generate movable transparent overlays after programming a pacemaker, to be used in interpreting subsequent rhythm strips.

[Lead poisoning: towards a paleo-epidemiologic re-interpretation?].

PubMed

Bourdieu, Anne

2014-01-01

Lead is a major public health issue. Its use has been increasing since Neolithic times, climaxing in the Ancient Rome and the nineteenth century. Defining the frequency of plumbism before modern times proves to be a difficult matter because of its various and delayed symptoms, and of diagenetic processes affecting bones. After reviewing various methods of lead measurement in bone and tooth, we will expose ways to ascertain lead measurement interpretation in order to estimate the epidemiology of plumbism in ancient times.

A Community Database of Quartz Microstructures: Can we make measurements that constrain rheology?

NASA Astrophysics Data System (ADS)

Toy, Virginia; Peternell, Mark; Morales, Luiz; Kilian, Ruediger

2014-05-01

Rheology can be explored by performing deformation experiments, and by examining resultant microstructures and textures as links to naturally deformed rocks. Certain deformation processes are assumed to result in certain microstructures or textures, of which some might be uniquely indicative, while most cannot be unequivocally used to interpret the deformation mechanism and hence rheology. Despite our lack of a sufficient understanding of microstructure and texture forming processes, huge advances in texture measurements and quantification of microstructural parameters have been made. Unfortunately, there are neither standard procedures nor a common consensus on interpretation of many parameters (e.g. texture, grain size, shape preferred orientation). Textures (crystallographic preferred orientations) have been extensively correlated to the interpretation of deformation mechanisms. For example the strength of textures can be measured either from the orientation distribution function (e.g. the J-index (Bunge, 1983) or texture entropy (Hielscher et al., 2007) or via the intensity of polefigures. However, there are various ways to identify a representative volume, to measure, to process the data and to calculate an odf and texture descriptors, which restricts their use as a comparative and diagnostic measurement. Microstructural parameters such as grain size, grain shape descriptors and fabric descriptors are similarly used to deduce and quantify deformation mechanisms. However there is very little consensus on how to measure and calculate some of these very important parameters, e.g. grain size which makes comparison of a vast amount of precious data in the literature very difficult. We propose establishing a community database of a standard set of such measurements, made using typical samples of different types of quartz rocks through standard methods of microstructural and texture quantification. We invite suggestions and discussion from the community about the worth of proposed parameters, methodology and usefulness and willingness to contribute to a database with free access of the community. We further invite institutions to participate on a benchmark analysis of a set of 'standard' thin sections. Bunge, H.J. 1983, Texture Analysis in Materials Science: mathematical methods. Butterworth-Heinemann, 593pp. Hielscher, R., Schaeben, H., Chateigner, D., 2007, On the entropy to texture index relationship in quantitative texture analysis: Journal of Applied Crystallography 40, 371-375.

Autoadaptivity and optimization in distributed ECG interpretation.

PubMed

Augustyniak, Piotr

2010-03-01

This paper addresses principal issues of the ECG interpretation adaptivity in a distributed surveillance network. In the age of pervasive access to wireless digital communication, distributed biosignal interpretation networks may not only optimally solve difficult medical cases, but also adapt the data acquisition, interpretation, and transmission to the variable patient's status and availability of technical resources. The background of such adaptivity is the innovative use of results from the automatic ECG analysis to the seamless remote modification of the interpreting software. Since the medical relevance of issued diagnostic data depends on the patient's status, the interpretation adaptivity implies the flexibility of report content and frequency. Proposed solutions are based on the research on human experts behavior, procedures reliability, and usage statistics. Despite the limited scale of our prototype client-server application, the tests yielded very promising results: the transmission channel occupation was reduced by 2.6 to 5.6 times comparing to the rigid reporting mode and the improvement of the remotely computed diagnostic outcome was achieved in case of over 80% of software adaptation attempts.

On Test-Wiseness and Some Related Constructs

ERIC Educational Resources Information Center

Nilsson, Ingvar; Wedman, Ingemar

1976-01-01

States that, due to confusion of concepts and lack of systemization, "previous studies are often difficult to interpret and consequently...afford little possibility of formulating more precise statements about those errors the concepts represent...." A proposal for systematization is presented. (Author/RW)

Knowledge Management for Shared Awareness

DTIC Science & Technology

2013-05-01

how to think about behavior and operating status of difficult chemical plants (when the operator says : “It is unstable today”), the frame of...are used in a number of applications where the knowledge is amorphous and ill understood, like handwriting interpretation, seismic data

RESPONSE OF PLANT COMMUNITIES TO MULTIPLE STRESSES

EPA Science Inventory

Single species tests lack the ecological realism necessary to predict the effects of toxicants in natural environments. Field tests are expensive and the results can be difficult to interpret. To address these conflicting problems, open top chambers were modified to contain pla...

Acupuncture and Deaf-Mutism--An Essay in Cross-Cultural Defectology

ERIC Educational Resources Information Center

Sutton, Andrew

1977-01-01

Describes reportedly successful treatment of deaf-mutes in China by acupuncture, and suggests that the disorders might have been more psychological than physical. The author comments that interpretation of poorly documented reports from unfamiliar cultures is extremely difficult. (AV)

Collaborative Learning and Interpretation of Literature.

ERIC Educational Resources Information Center

Mayo, Wendell

Although there is abundant theoretical matter concerning the critical role that various interpretive communities play in making meanings of literary texts, most scholars do not take up the matter of the composition of these interpretive groups in their university classrooms. How may the interpretive strategies of groups of students change over the…

Experiencing cancer treatment decision-making in managed care.

PubMed

Wenzel, Jennifer; Shaha, Maya

2008-09-01

This paper is a report of a study to explore women's perceptions of and experiences with breast cancer treatment decision-making in managed care organizations (MCOs). Managed care organizations are the predominant form of employer-sponsored healthcare insurance in the United States of America. These healthcare financing entities minimize cost by streamlining healthcare delivery and may impose choice restrictions. The extent of these restrictions has not previously been studied from an in-depth patient perspective. A qualitative descriptive approach was adopted using interviews with a purposive sample of 14 managed care enrollees diagnosed with breast cancer at all stages. The data were collected between 2003 and 2005. Data analysis involved a reflexive process of transcript reading, categorization, data reduction and interpretation. The findings are presented as a single theme: 'decisional conflict in managed care', with two distinct categories: decisions regarding (1) the MCOs and (2) treatment. MCO selection was perceived to be limited by employer constraints, cost issues or healthcare plan providers. For study participants, selecting a MCO was less difficult than issues surrounding treatment decision-making. Women reported that their most important treatment-related decisions surrounded diagnosis and involved selecting a treatment facility and provider. Once a satisfactory facility and provider were selected, these women preferred to defer treatment decisions to their healthcare providers. Decision interventions should be focused on assisting women with provider and treatment facility selection early in diagnosis. Our findings might also serve as a basis for policy/practice changes to address healthcare financing limitations and to expand cancer treatment-related choices while providing desired treatment decision-making support.

A Rhizotextual Analysis of Philippine Secondary Textbooks in History

ERIC Educational Resources Information Center

Nery-Cura, Ma. Lourdes S.; de Guzman, Allan B.

2018-01-01

Textbooks, as a curriculum document text, are subject to nonlinear entry and points of interpretation and implementation. The interpretation of its content is dependent on the reader or the writer, thus making it open to multimodal ways of meaning-making that underscore rhizomatic tendencies. Delueze and Guattari ("A thousand plateaus:…

29 CFR 471.21 - Who will make rulings and interpretations under Executive Order 13496 and this part?

Code of Federal Regulations, 2010 CFR

2010-07-01

...-MANAGEMENT STANDARDS, DEPARTMENT OF LABOR NOTIFICATION OF EMPLOYEE RIGHTS UNDER FEDERAL LABOR LAWS OBLIGATIONS OF FEDERAL CONTRACTORS AND SUBCONTRACTORS; NOTIFICATION OF EMPLOYEE RIGHTS UNDER FEDERAL LABOR... 29 Labor 2 2010-07-01 2010-07-01 false Who will make rulings and interpretations under Executive...

Perception, Interpretation and Decision Making: Understanding Gaps between Competence and Performance--A Commentary

ERIC Educational Resources Information Center

Mason, John

2016-01-01

This papers comments on the contributions of "ZDM Mathematics Education" dedicated to the theme "Perception, interpretation and decision making: understanding the missing link between competence and performance". The papers within this issue are brought together under the perspective of the stated aims of this issue, and then…

The quality of emergency room radiograph interpretations.

PubMed

McLain, P L; Kirkwood, C R

1985-05-01

Primary care physicians often make patient management decisions based in part on their own interpretations of radiographs. This important area of clinical decision making has not been previously analyzed in the literature. In this series of 294 consecutive radiographs from rural practice, interpretative disagreement between primary care providers and backup radiologists occurred 9.2 percent of the time, a discordance rate similar to that seen among radiologists in other studies. Although a majority of the films for which interpretative disagreement occurred had potential implications for influencing patient management, in only seven cases did actual case management vary from appropriate norms. Follow-up of cases where interpretative disagreement occurred revealed that in only two cases did unsatisfactory outcomes occur. Primary care physicians can provide high-quality radiographic interpretations that, when coupled with clinical information, yield extremely low rates of error or potential for poor patient outcomes.

Structural interpretation and physical property estimates based on COAST 2012 seismic reflection profiles offshore central Washington, Cascadia subduction zone

NASA Astrophysics Data System (ADS)

Webb, S. I.; Tobin, H. J.; Everson, E. D.; Fortin, W.; Holbrook, W. S.; Kent, G.; Keranen, K. M.

2014-12-01

The Cascadia subduction zone has a history of large magnitude earthquakes, but a near-total lack of plate interface seismicity, making the updip limit of the seismogenic zone difficult to locate. In addition, the central Cascadia accretionary prism is characterized by an extremely low wedge taper angle, landward vergent initial thrusting, and a flat midslope terrace between the inner and outer wedges, unlike most other accretionary prisms (e.g. the Nankai Trough, Japan). The Cascadia Open Access Seismic Transect (COAST) lines were shot by R/V Marcus Langseth in July of 2012 off central Washington to image this subduction zone. Two trench-parallel and nine trench-perpendicular lines were collected. In this study, we present detailed seismic interpretation of both time- and depth-migrated stacked profiles, focused on elucidating the deposition and deformation of both pre- and syn-tectonic sediment in the trench and slope. Distribution and timing of sediments and their deformation is used to unravel the evolution of the wedge through time. Initially, interpretation of the time-sections is carried out to support the building of tomographic velocity models to aid in the pre-stack depth migration (PSDM) of selected lines. In turn, we use PSDM velocity models to estimate porosity and pore pressure conditions at the base of the wedge and across the basal plate interface décollement where possible, using established velocity-porosity transforms. Interpretation in this way incorporates both accurate structural relationships and robust porosity models to document wedge development and present-day stress state, in particular regions of potential overpressure. Results shed light on the origin and evolution of the mid-slope terrace and the low taper angle for the forearc wedge. This work may shed light ultimately on the position of the potential updip limit of the seismogenic zone beneath the wedge.

The Junction of Hellenic and Cyprus Arcs: a Detailed Study of the Morphology and Neogene Tectonic Evolution of the Anaximander Mountains

NASA Astrophysics Data System (ADS)

Cranshaw, J.; Aksu, A.; Hall, J.; Cifci, G.; Dondurur, D.; Yaltirak, C.

2009-05-01

The Anaximander Mountains are enigmatic highs located at the complex corner that links the Cyprus and Hellenic Arcs in the eastern Mediterranean. They are made up of several different highs: Anaximander (sensu stricto), Anaxagoras and Anaximenes. Previous work had shown that rock samples from the Anaximander Mountain have affinity with rocks exposed on land nearby in southern Turkey. This had been explained by rifting of the Mountain away from Turkey. In contrast to that, our interpretation of around 1750 km of high-resolution multi-channel seismic reflection data acquired in 2001 showed that Anaximander Mountain is part of a broadly south-verging Miocene thrust system associated with relative southward motion of the Tauride Mountains in southern Turkey. Post-Miocene motion also involves thrusting but is accompanied by transpression and rotation. The 3-dimensional nature of the geology makes mapping of the linkage of structures difficult, so we collected an additional 500 km of multi-channel seismic reflection data acquired in 2007, extending our 2001 survey further southwards into the Mediterranean Ridge. These new profiles are shot in a grid oblique to that obtained in 2001, such that the new profile intersections provide a basis for better correlation of the earlier data. We are testing our earlier interpretation through processing and interpretation of these new profiles. Here, we present examples of the new profiles and give first indications of how our earlier interpretation is broadly corroborated by the new data, but with minor adjustments. Anaximenes Mountain is imaged to the south of our previously- mapped area and is characterized as a large south-verging thrust lifting pre-Messinian strata by up to 2 km in a 12-km wide pop-up structure. Internally, Anaximenes is dissected by several splays from the bounding thrusts.

The junction of Hellenic and Cyprus arcs: a detailed study of the morphology and Neogene tectonic evolution of the Anaximander Mountains

NASA Astrophysics Data System (ADS)

Cranshaw, J.; Aksu, A.; Hall, J.; Çifçi, G.; Dondurur, D.; Yaltırak, C.

2009-04-01

The Anaximander Mountains are enigmatic highs located at the complex corner that links the Cyprus and Hellenic Arcs in the eastern Mediterranean. They are made up of several different highs: Anaximander (sensu stricto), Anaxagoras and Anaximenes. Previous work had shown that rock samples from the Anaximander Mountain have affinity with rocks exposed on land nearby in southern Turkey. This had been explained by rifting of the Mountain away from Turkey. In contrast to that, our interpretation of around 1750 km of high-resolution multi-channel seismic reflection data acquired in 2001 showed that Anaximander Mountain is part of a broadly south-verging Miocene thrust system associated with relative southward motion of the Tauride Mountains in southern Turkey. Post-Miocene motion also involves thrusting but is accompanied by transpression and rotation. The 3-dimensional nature of the geology makes mapping of the linkage of structures difficult, so we collected an additional 500 km of multi-channel seismic reflection data acquired in 2007, extending our 2001 survey further southwards into the Mediterranean Ridge. These new profiles are shot in a grid oblique to that obtained in 2001, such that the new profile intersections provide a basis for better correlation of the earlier data. We are testing our earlier interpretation through processing and interpretation of these new profiles. Here, we present examples of the new profiles and give first indications of how our earlier interpretation is broadly corroborated by the new data, but with minor adjustments. Anaximenes Mountain is imaged to the south of our previously-mapped area and is characterized as a large south-verging thrust lifting pre-Messinian strata by up to 2 km in a 12-km wide pop-up structure. Internally, Anaximenes is dissected by several splays from the bounding thrusts.

FreeWalker: a smart insole for longitudinal gait analysis.

PubMed

Wang, Baitong; Rajput, Kuldeep Singh; Tam, Wing-Kin; Tung, Anthony K H; Yang, Zhi

2015-08-01

Gait analysis is an important diagnostic measure to investigate the pattern of walking. Traditional gait analysis is generally carried out in a gait lab, with equipped force and body tracking sensors, which needs a trained medical professional to interpret the results. This procedure is tedious, expensive, and unreliable and makes it difficult to track the progress across multiple visits. In this paper, we present a smart insole called FreeWalker, which provides quantitative gait analysis outside the confinement of traditional lab, at low- cost. The insole consists of eight pressure sensors and two motion tracking sensors, i.e. 3-axis accelerometer and 3-axis gyroscope. This enables measurement of under-foot pressure distribution and motion sequences in real-time. The insole is enabled with onboard SD card as well as wireless data transmission, which help in continuous gait-cycle analysis. The data is then sent to a gateway, for analysis and interpretation of data, using a user interface where gait features are graphically displayed. We also present validation result of a subject's left foot, who was asked to perform a specific task. Experiment results show that we could achieve a data-sampling rate of over 1 KHz, transmitting data up to a distance of 20 meter and maintain a battery life of around 24 hours. Taking advantage of these features, FreeWalker can be used in various applications, like medical diagnosis, rehabilitation, sports and entertainment.

Wavelet theory applied to the study of spectra of trans-Neptunian objects

NASA Astrophysics Data System (ADS)

Souza-Feliciano, A. C.; Alvarez-Candal, A.; Jiménez-Teja, Y.

2018-06-01

Context. Reflection spectroscopy in the near-infrared (NIR) is used to investigate the surface composition of trans-Neptunian objects (TNOs). In general, these spectra are difficult to interpret due to the low apparent brightness of the TNOs, causing low signal-to-noise ratio even in spectra obtained with the largest telescopes available on Earth, making it necessary to use filtering techniques to analyze and interpret them. Aims: The purpose of this paper is to present a methodology to analyze the spectra of TNOs. Specifically, our aim was to filter these spectra in the best possible way: maximizing noise removal, while minimizing the loss of signal. Methods: We used wavelets to filter the spectra. Wavelets are a mathematical tool that decompose the signal into its constituent parts, allowing us to analyze the data in different areas of frequencies with the resolution of each component tied to its scale. To check the reliability of our method, we compared the filtered spectra with the spectra of water and methanol ices to identify some common structures between them. Results: Of the 50 TNOs in our sample, we identify traces of water ices and methanol in the spectra of several of them, some with previous reports, while for other objects there were no previous reports. Conclusions: We conclude that the wavelet technique is successful in filtering spectra of TNOs.

Behavior-based aggregation of land categories for temporal change analysis

NASA Astrophysics Data System (ADS)

Aldwaik, Safaa Zakaria; Onsted, Jeffrey A.; Pontius, Robert Gilmore, Jr.

2015-03-01

Comparison between two time points of the same categorical variable for the same study extent can reveal changes among categories over time, such as transitions among land categories. If many categories exist, then analysis can be difficult to interpret. Category aggregation is the procedure that combines two or more categories to create a single broader category. Aggregation can simplify interpretation, and can also influence the sizes and types of changes. Some classifications have an a priori hierarchy to facilitate aggregation, but an a priori aggregation might make researchers blind to important category dynamics. We created an algorithm to aggregate categories in a sequence of steps based on the categories' behaviors in terms of gross losses and gross gains. The behavior-based algorithm aggregates net gaining categories with net gaining categories and aggregates net losing categories with net losing categories, but never aggregates a net gaining category with a net losing category. The behavior-based algorithm at each step in the sequence maintains net change and maximizes swap change. We present a case study where data from 2001 and 2006 for 64 land categories indicate change on 17% of the study extent. The behavior-based algorithm produces a set of 10 categories that maintains nearly the original amount of change. In contrast, an a priori aggregation produces 10 categories while reducing the change to 9%. We offer a free computer program to perform the behavior-based aggregation.

Serological diagnosis of Epstein-Barr virus infection: Problems and solutions

PubMed Central

De Paschale, Massimo; Clerici, Pierangelo

2012-01-01

Serological tests for antibodies specific for Epstein-Barr virus (EBV) antigens are frequently used to define infection status and for the differential diagnosis of other pathogens responsible for mononucleosis syndrome. Using only three parameters [viral capsid antigen (VCA) IgG, VCA IgM and EBV nuclear antigen (EBNA)-1 IgG],it is normally possible to distinguish acute from past infection: the presence of VCA IgM and VCA IgG without EBNA-1 IgG indicates acute infection, whereas the presence of VCA IgG and EBNA-1 IgG without VCA IgM is typical of past infection. However, serological findings may sometimes be difficult to interpret as VCA IgG can be present without VCA IgM or EBNA-1 IgG in cases of acute or past infection, or all the three parameters may be detected simultaneously in the case of recent infection or during the course of reactivation. A profile of isolated EBNA-1 IgG may also create some doubts. In order to interpret these patterns correctly, it is necessary to determine IgG avidity, identify anti-EBV IgG and IgM antibodies by immunoblotting, and look for heterophile antibodies, anti-EA (D) antibodies or viral genome using molecular biology methods. These tests make it possible to define the status of the infection and solve any problems that may arise in routine laboratory practice. PMID:24175209

Noble Gas Leak Detector for Use in the SNS Neutron Electric Dipole Moment Experiment

NASA Astrophysics Data System (ADS)

Barrow, Chad; Huffman, Paul; Leung, Kent; Korobkina, Ekaterina; White, Christian; nEDM Collaboration Collaboration

2017-09-01

Common practice for leak-checking high vacuum systems uses helium as the probing gas. However, helium may permeate some materials at room temperature, making leak characterization difficult. The experiment to find a permanent electric dipole moment of the neutron (nEDM), to be conducted at Oak Ridge National Laboratories, will employ a large volume of liquid helium housed by such a helium-permeable composite material. It is desirable to construct a leak detector that can employ alternative test gases. The purpose of this experiment is to create a leak detector that can quantify the argon gas flux in a high vacuum environment and interpret this flux as a leak-rate. This apparatus will be used to check the nEDM volumes for leaks at room temperature before cooling down to cryogenic temperatures. Our leak detector uses a residual gas analyzer and a vacuum pumping station to characterize the gas present in an evacuated volume. The introduction of argon gas into the system is interpreted as a leak-rate into the volume. The device has been calibrated with NIST certified calibrated leaks and the machine's sensitivity has been calculated using background gas analysis. As a result of the device construction and software programming, we are able to leak-check composite and polyamide volumes This work was supported in part by the US Department of Energy under Grant No. DE-FG02-97ER41042.

Cardiovascular disease among atomic bomb survivors.

PubMed

Ozasa, Kotaro; Takahashi, Ikuno; Grant, Eric J; Kodama, Kazunori

2017-10-01

The profile of cardiovascular disease in Japan has been different from that in Western countries. Hypertension was the major cause not only for hemorrhagic stroke but also for ischemic stroke and heart disease in the past, and the influence of hypertension has decreased with calendar years because of reduced salt intake and westernization of lifestyle, and also improved medical care. The health status of atomic bomb survivors has reflected this profile as well as radiation effects. It is also likely that this cohort has been affected by the difficult conditions experienced in the aftermath of the war and atomic bombings. In this article, we tried to make a consistent interpretation of epidemiological findings of atomic bomb radiation effects on cardiovascular disease. Among the atomic bomb survivors, radiation exposure was associated with some cardiovascular diseases that are often associated with hypertension, and dose response appeared to be primarily non-linear among those who were exposed at younger ages. These effects are thought to reflect the nature of whole body irradiation. But, some findings remain inconsistent, possibly because of possible misclassification in death certificate diagnoses in the Life Span Study as well as selected information from the Adult Health Study which was limited to participants, focused on specific outcomes, and gathered in selected periods of follow-up. Therefore, a comprehensive and balanced interpretation of the results from both groups is necessary.

The Opera Instrument: An Advanced Curation Development for Mars Sample Return Organic Contamination Monitoring

NASA Technical Reports Server (NTRS)

Fries, M. D.; Fries, W. D.; McCubbin, F. M.; Zeigler, R. A.

2018-01-01

Mars Sample Return (MSR) requires strict organic contamination control (CC) and contamination knowledge (CK) as outlined by the Mars 2020 Organic Contamination Panel (OCP). This includes a need to monitor surficial organic contamination to a ng/sq. cm sensitivity level. Archiving and maintaining this degree of surface cleanliness may be difficult but has been achieved. MSR's CK effort will be very important because all returned samples will be studied thoroughly and in minute detail. Consequently, accurate CK must be collected and characterized to best interpret scientific results from the returned samples. The CK data are not only required to make accurate measurements and interpretations for carbon-depleted martian samples, but also to strengthen the validity of science investigations performed on the samples. The Opera instrument prototype is intended to fulfill a CC/CK role in the assembly, cleaning, and overall contamination history of hardware used in the MSR effort, from initial hardware assembly through post-flight sample curation. Opera is intended to monitor particulate and organic contamination using quartz crystal microbalances (QCMs), in a self-contained portable package that is cleanroom-compliant. The Opera prototype is in initial development capable of approximately 100 ng/sq. cm organic contamination sensitivity, with additional development planned to achieve 1 ng/sq. cm. The Opera prototype was funded by the 2017 NASA Johnson Space Center Innovation Charge Account (ICA), which provides funding for small, short-term projects.

Morphological diagnostics of star formation in molecular clouds

NASA Astrophysics Data System (ADS)

Beaumont, Christopher Norris

Molecular clouds are the birth sites of all star formation in the present-day universe. They represent the initial conditions of star formation, and are the primary medium by which stars transfer energy and momentum back to parsec scales. Yet, the physical evolution of molecular clouds remains poorly understood. This is not due to a lack of observational data, nor is it due to an inability to simulate the conditions inside molecular clouds. Instead, the physics and structure of the interstellar medium are sufficiently complex that interpreting molecular cloud data is very difficult. This dissertation mitigates this problem, by developing more sophisticated ways to interpret morphological information in molecular cloud observations and simulations. In particular, I have focused on leveraging machine learning techniques to identify physically meaningful substructures in the interstellar medium, as well as techniques to inter-compare molecular cloud simulations to observations. These contributions make it easier to understand the interplay between molecular clouds and star formation. Specific contributions include: new insight about the sheet-like geometry of molecular clouds based on observations of stellar bubbles; a new algorithm to disambiguate overlapping yet morphologically distinct cloud structures; a new perspective on the relationship between molecular cloud column density distributions and the sizes of cloud substructures; a quantitative analysis of how projection effects affect measurements of cloud properties; and an automatically generated, statistically-calibrated catalog of bubbles identified from their infrared morphologies.

Challenge of biomechanics.

PubMed

Volokh, K Y

2013-06-01

The application of mechanics to biology--biomechanics--bears great challenges due to the intricacy of living things. Their dynamism, along with the complexity of their mechanical response (which in itself involves complex chemical, electrical, and thermal phenomena) makes it very difficult to correlate empirical data with theoretical models. This difficulty elevates the importance of useful biomechanical theories compared to other fields of engineering. Despite inherent imperfections of all theories, a well formulated theory is crucial in any field of science because it is the basis for interpreting observations. This is all-the-more vital, for instance, when diagnosing symptoms, or planning treatment to a disease. The notion of interpreting empirical data without theory is unscientific and unsound. This paper attempts to fortify the importance of biomechanics and invigorate research efforts for those engineers and mechanicians who are not yet involved in the field. It is not aimed here, however, to give an overview of biomechanics. Instead, three unsolved problems are formulated to challenge the readers. At the micro-scale, the problem of the structural organization and integrity of the living cell is presented. At the meso-scale, the enigma of fingerprint formation is discussed. At the macro-scale, the problem of predicting aneurysm ruptures is reviewed. It is aimed here to attract the attention of engineers and mechanicians to problems in biomechanics which, in the author's opinion, will dominate the development of engineering and mechanics in forthcoming years.

Gender boundaries and sexual categories in the Arab world.

PubMed

Abukhalil, A

1997-01-01

This essay considers the construction of gender and sexual images in the Arab world and how Western responses to Islam have affected the way Islam is perceived and interpreted. After a brief introduction, the essay discusses the problems of using Islam as a standard methodological yardstick in the face of the diversity of Muslim lifestyles and interpretations. The next section describes gender boundaries and social barriers in Islam that involve rigid segregation of the sexes. While Islam is shown not to favor full gender equality, the dynamic interaction between a Middle Eastern culture and the Islamic religion, each of which promote the ostensible inferiority of women, makes it difficult to determine whether culture or religion has had more influence on gender relations. The essay continues with a look at controversies about homosexuality, the condition that defined the difference between Christianity and Islam. Characteristics of present-day sexism and sexuality among the Arabs are highlighted in a look at the persistence of male dominance, the restriction of women from the public sphere, theories about the toleration of homosexuality, and the taboo extended towards lesbians and others practicing free sex. It is concluded that the study of gender and sexuality in the Middle East remains incomplete and preliminary, although gender studies have progressed in the past two decades. Social and sexual tensions have been exacerbated by the rise of fundamentalism, and homosexuality remains a forbidden topic for Muslim scholars.

Mendelian randomization analyses in cardiometabolic disease: challenges in evaluating causality

PubMed Central

Holmes, Michael V; Ala-Korpela, Mika; Davey Smith, George

2017-01-01

Mendelian randomization (MR) is a burgeoning field that involves the use of genetic variants to assess causal relationships between exposures and outcomes. MR studies can be straightforward; for example, genetic variants within or near the encoding locus that is associated with protein concentrations can help to assess their causal role in disease. However, a more complex relationship between the genetic variants and an exposure can make findings from MR more difficult to interpret. In this Review, we describe some of these challenges in interpreting MR analyses, including those from studies using genetic variants to assess causality of multiple traits (such as branched-chain amino acids and risk of diabetes mellitus); studies describing pleiotropic variants (for example, C-reactive protein and its contribution to coronary heart disease); and those investigating variants that disrupt normal function of an exposure (for example, HDL cholesterol or IL-6 and coronary heart disease). Furthermore, MR studies on variants that encode enzymes responsible for the metabolism of an exposure (such as alcohol) are discussed, in addition to those assessing the effects of variants on time-dependent exposures (extracellular superoxide dismutase), cumulative exposures (LDL cholesterol), and overlapping exposures (triglycerides and non-HDL cholesterol). We elaborate on the molecular features of each relationship, and provide explanations for the likely causal associations. In doing so, we hope to contribute towards more reliable evaluations of MR findings. PMID:28569269

The difficult mountain: enriched composition in adjective–noun phrases

PubMed Central

Pickering, Martin J.; McElree, Brian

2012-01-01

When readers need to go beyond the straightforward compositional meaning of a sentence (i.e., when enriched composition is required), costly additional processing is the norm. However, this conclusion is based entirely on research that has looked at enriched composition between two phrases or within the verb phrase (e.g., the verb and its complement in … started the book …) where there is a discrepancy between the semantic expectations of the verb and the semantics of the noun. We carried out an eye-tracking experiment investigating enriched composition within a single noun phrase, as in the difficult mountain. As compared with adjective–noun phrases that allow a straightforward compositional interpretation (the difficult exercise), the coerced phrases were more difficult to process. These results indicate that coercion effects can be found in the absence of a typing violation and within a single noun phrase. PMID:21826403

Ameloblastic fibrosarcoma. Report of a case in a Nigerian.

PubMed

Adekeye, E O; Edwards, M B; Goubran, G F

1978-08-01

Ameloblastic fibrosarcoma is very rare and has not previously been reported from Nigeria. The case described here had typical clinical features, but the microscopic findings were unusual and difficult to interpret. The pathogenetic relationship between ameloblastic fibroma and fibrosarcoma is discussed.

Linkage of genomic biomarkers to whole organism endpoints in a Toxicity Identification Evaluation (TIE).

EPA Science Inventory

Aquatic organisms are exposed to many toxic chemicals and interpreting the cause and effect relationships between occurrence and impairment is difficult. Toxicity Identification Evaluation (TIE) provides a systematic approach for identifying responsible toxicants. TIE relies on ...

Evaluation of Reagent-Impregnated Coagulase-Mannitol Test Strip for Speciation of Staphylococci

PubMed Central

Washington, John A.; Yu, Pauline K. W.

1970-01-01

A new coagulase-mannitol reagent-impregnated strip test has been evaluated with 322 Micrococcaceae. Mannitol fermentation was determined accurately by this test; however, the coagulase reaction was difficult to interpret and was subject to significant error. PMID:5418952

Human evolution in the age of the intelligent machine

NASA Technical Reports Server (NTRS)

Mclaughlin, W. I.

1983-01-01

A systems analysis of the future evolution of man can be conducted by analyzing the biological material of the galaxy into three subsystems: man, intelligent machines, and intelligent extraterrestrial organisms. A binomial interpretation is applied to this system wherein each of the subsystems is assigned a designation of success or failure. For man the two alternatives are, respectively, 'decline' or 'flourish', for machine they are 'become intelligent' or 'stay dumb', while for extraterrestrial intelligence the dichotomy is that of 'existence' or 'nonexistence'. The choices for each of three subsystems yield a total of eight possible states for the system. The relative lack of integration between brain components makes man a weak evolutionary contestant compared to machines. It is judged that machines should become dominant on earth within 100 years, probably by means of continuing development of existing man-machine systems. Advanced forms of extraterrestrial intelligence may exist but are too difficult to observe. The prospects for communication with extraterrestrial intelligence are reviewed.

Mutant mouse models and their contribution to our knowledge of corpus luteum development, function and regression.

PubMed

Henkes, Luiz E; Davis, John S; Rueda, Bo R

2003-11-10

The corpus luteum is a unique organ, which is transitory in nature. The development, maintenance and regression of the corpus luteum are regulated by endocrine, paracrine and autocrine signaling events. Defining the specific mediators of luteal development, maintenance and regression has been difficult and often perplexing due to the complexity that stems from the variety of cell types that make up the luteal tissue. Moreover, some regulators may serve dual functions as a luteotropic and luteolytic agent depending on the temporal and spatial environment in which they are expressed. As a result, some confusion is present in the interpretation of in vitro and in vivo studies. More recently investigators have utilized mutant mouse models to define the functional significance of specific gene products. The goal of this mini-review is to identify and discuss mutant mouse models that have luteal anomalies, which may provide some clues as to the significance of specific regulators of corpus luteum function.

Peer Influence, Genetic Propensity, and Binge Drinking: A Natural Experiment and a Replication.

PubMed

Guo, Guang; Li, Yi; Wang, Hongyu; Cai, Tianji; Duncan, Greg J

2015-11-01

The authors draw data from the College Roommate Study (ROOM) and the National Longitudinal Study of Adolescent Health to investigate gene-environment interaction effects on youth binge drinking. In ROOM, the environmental influence was measured by the precollege drinking behavior of randomly assigned roommates. Random assignment safeguards against friend selection and removes the threat of gene-environment correlation that makes gene-environment interaction effects difficult to interpret. On average, being randomly assigned a drinking peer as opposed to a nondrinking peer increased college binge drinking by 0.5-1.0 episodes per month, or 20%-40% the average amount of binge drinking. However, this peer influence was found only among youths with a medium level of genetic propensity for alcohol use; those with either a low or high genetic propensity were not influenced by peer drinking. A replication of the findings is provided in data drawn from Add Health. The study shows that gene-environment interaction analysis can uncover social-contextual effects likely to be missed by traditional sociological approaches.

Software phantom with realistic speckle modeling for validation of image analysis methods in echocardiography

NASA Astrophysics Data System (ADS)

Law, Yuen C.; Tenbrinck, Daniel; Jiang, Xiaoyi; Kuhlen, Torsten

2014-03-01

Computer-assisted processing and interpretation of medical ultrasound images is one of the most challenging tasks within image analysis. Physical phenomena in ultrasonographic images, e.g., the characteristic speckle noise and shadowing effects, make the majority of standard methods from image analysis non optimal. Furthermore, validation of adapted computer vision methods proves to be difficult due to missing ground truth information. There is no widely accepted software phantom in the community and existing software phantoms are not exible enough to support the use of specific speckle models for different tissue types, e.g., muscle and fat tissue. In this work we propose an anatomical software phantom with a realistic speckle pattern simulation to _ll this gap and provide a exible tool for validation purposes in medical ultrasound image analysis. We discuss the generation of speckle patterns and perform statistical analysis of the simulated textures to obtain quantitative measures of the realism and accuracy regarding the resulting textures.

Identification of non-technical skills from the resilience engineering perspective: a case study of an electricity distributor.

PubMed

Wachs, Priscila; Righi, Angela Weber; Saurin, Tarcisio Abreu

2012-01-01

Training in non-technical skills (NTS) does not usually question the design of the work system, and thus focuses narrowly on workers as the unit of analysis. This study discusses how the identification of NTS, a major step for developing an NTS training program, might be re-interpreted from the perspective of resilience engineering (RE). This discussion is based on a case study of identifying NTS for electricians who perform emergency maintenance activities in an electricity distribution power line. The results of the case study point out that four data analysis procedures might operationalize the RE perspective: (a) identifying factors that make the work difficult and which could be integrated into NTS training scenarios; (b) identifying recommendations for re-designing the system, in order either to reduce or eliminate the need for NTS; (c) classifying the NTS into pragmatic categories, which are meaningful for workers; and (d) regarding the identification of NTS as an opportunity to give visibility to adaptations carried out by workers.

3D Animations for Exploring Nucleon Structure

NASA Astrophysics Data System (ADS)

Gorman, Waverly; Burkardt, Matthias

2016-09-01

Over the last few years many intuitive pictures have been developed for the interpretation of electron hadron scattering experiments, such as a mechanism for transverse single-spin asymmetries in semi-inclusive deep-inelastic scattering experiments. While Dr. Burkardt's pictures have been helpful for many researchers in the field, they are still difficult to visualize for broader audiences since they rely mostly on 2-dimensional static images. In order to make more accessible for a broader audience what can be learned from Jefferson Lab experiments, we have started to work on developing 3-dimensional animations for these processes. The goal is to enable the viewer to repeatedly look at the same microscopic mechanism for a specific reaction, with the viewpoint of the observer changing. This should help an audience that is not so familiar with these reactions to better understand what can be learned from various experiments at Jefferson Lab aimed at exploring the nucleon structure. Jefferson Lab Minority/Female Undergraduate Research Assistantship.

Simulation of RBS spectra with known 3D sample surface roughness

NASA Astrophysics Data System (ADS)

Malinský, Petr; Siegel, Jakub; Hnatowicz, Vladimir; Macková, Anna; Švorčík, Václav

2017-09-01

The Rutherford Backscattering Spectrometry (RBS) is a technique for elemental depth profiling with a nanometer depth resolution. Possible surface roughness of analysed samples can deteriorate the RBS spectra and makes their interpretation more difficult and ambiguous. This work describes the simulation of RBS spectra which takes into account real 3D morphology of the sample surface obtained by AFM method. The RBS spectrum is calculated as a sum of the many particular spectra obtained for randomly chosen particle trajectories over sample 3D landscape. The spectra, simulated for different ion beam incidence angles, are compared to the experimental ones measured with 2.0 MeV 4He+ ions. The main aim of this work is to obtain more definite information on how a particular surface morphology and measuring geometry affects the RBS spectra and derived elemental depth profiles. A reasonable agreement between the measured and simulated spectra was found and the results indicate that the AFM data on the sample surface can be used for the simulation of RBS spectra.

An Evaluation of Sea Surface Temperature as Measured by the Nimbus 1 High Resolution Infrared Radiometer

NASA Technical Reports Server (NTRS)

Allison, Lewis J.; Kennedy, James S.

1967-01-01

An analysis of Nimbus I HRIR data over various parts of the world indicated limited success in deriving sea surface temperatures to within 3 to 6 K of aircraft radiation measurements (8- 13 microns) and synoptic-climatological ship sea surface temperature data. The areas studied included the east, west and Gulf coasts of the United States, West Greenland, Nova Scotia, southern Japan, the eastern Mediterranean Sea, Caspian Sea, Persian Gulf, and the Indian Ocean. At night, thin clouds which may fill the radiometer's field of view make it difficult to interpret the absolute values of derived sea surface temperature. During the daytime, the HRIR data is unusable for oceanographic temperature analysis because the contamination by reflected solar radiation mixes with the emitted radiation. Future satellite instrumentation, consisting of a HFUR radiometer (10-11 microns) when used in conjunction with television. data, will delineate cloud free ocean areas and permit the daily derivation of sea surface temperatures from approximately 10 to 30 Percent of the world's oceanic regions.

[Significance of sex and gender studies for anthropology].

PubMed

Kirchengast, Sylvia

2004-09-01

The formation of a special working group for gender studies within the German Anthropological Society (GfA) makes necessary a description of history as well as topics of gender studies within science and biological anthropology. In German speaking countries, gender studies are predominantly associated with social and cultural sciences, although very successful working groups belonging to natural sciences already exist. Unfortunately, up to now gender studies within natural sciences are often interpreted negatively and the existence of sex is denied. This may be due to the long and difficult history of gender studies in natural sciences. For a long time, pseudoscientific misinterpretations of results of gender studies were used to manifest the inferior social position of women. However, since more than thirty years respectable gender studies are integrated in social as well as natural sciences. Gender studies are integrative parts of nearly all subdisciplines of biological anthropology. The formation of a working group for gender studies within the GfA seems therefore to be useful.

Anisotropic surface physicochemical properties of spodumene and albite crystals: Implications for flotation separation

NASA Astrophysics Data System (ADS)

Xu, Longhua; Peng, Tiefeng; Tian, Jia; Lu, Zhongyuan; Hu, Yuehua; Sun, Wei

2017-12-01

Aluminosilicate minerals (e.g., spodumene, albite) have complex crystal structures and similar surface chemistries, but they have poor selectivity compared to traditional fatty acid collectors, making flotation separation difficult. Previous research has mainly considered the mineral crystal structure as a whole. In contrast, the surface characteristics at the atomic level and the effects of different crystal interfaces on the flotation behavior have rarely been investigated. This study focuses on investigating the surface anisotropy quantitatively, including the chemical bond characteristics, surface energies, and broken bond densities, using density functional theory and classical theoretical calculations. In addition, the anisotropy of the surface wettability and adsorption characteristics were examined using contact angle, zeta potential, and Fourier-transform infrared measurements. Finally, these surface anisotropies with different flotation behaviors were investigated and interpreted using molecular dynamics simulations, scanning electron microscopy, and X-ray photoelectron spectroscopy. This systematic research offers new ideas concerning the selective grinding and stage flotation of aluminosilicate minerals based on the crystal characteristics.

Environmental contaminants in tissues, foods, and feces of California condors

USGS Publications Warehouse

Wiemeyer, Stanley N.; Krynitsky, A.J.; Wilbur, S.R.; Wilbur, Sanford R.; Jackson, Jerome A.

1983-01-01

Two wild California Condors contained moderate to high levels of DDE in their tissues. The levels found could be high enough to cause reproductive problems in adult condors, if the assumption is made that condors are as susceptible to DDE as many other species of birds of prey. Other organochlorines occurred at low levels and probably were not high enough to cause deleterious effects. Metal residues in tissues of one bird were generally low except for copper in liver and lead in bone. Normal background levels of these metals in cathartids are unknown, making interpretation of the results difficult. Organochlorine residues in biopsy samples from a captive condor were low and probably would not have an adverse effect on reproduction if the bird were used for captive breeding. Organochlorines were not detected in food items used in the supplemental feeding program, and mercury and lead residues in these items were generally low. Information is needed on current contaminant levels in natural condor prey throughout the condor range.

Complement C5-inhibiting therapy for the thrombotic microangiopathies: accumulating evidence, but not a panacea

PubMed Central

Brocklebank, Vicky

2017-01-01

Abstract Thrombotic microangiopathy (TMA), characterized by organ injury occurring consequent to severe endothelial damage, can manifest in a diverse range of diseases. In complement-mediated atypical haemolytic uraemic syndrome (aHUS) a primary defect in complement, such as a mutation or autoantibody leading to over activation of the alternative pathway, predisposes to the development of disease, usually following exposure to an environmental trigger. The elucidation of the pathogenesis of aHUS resulted in the successful introduction of the complement inhibitor eculizumab into clinical practice. In other TMAs, although complement activation may be seen, its role in the pathogenesis remains to be confirmed by an interventional trial. Although many case reports in TMAs other than complement-mediated aHUS hint at efficacy, publication bias, concurrent therapies and in some cases the self-limiting nature of disease make broader interpretation difficult. In this article, we will review the evidence for the role of complement inhibition in complement-mediated aHUS and other TMAs. PMID:28980670

On the use of external burning to reduce aerospace vehicle transonic drag

NASA Technical Reports Server (NTRS)

Trefny, Charles J.

1990-01-01

The external combustion of hydrogen to reduce the transonic drag of aerospace vehicles is currently being investigated. A preliminary analysis based on a constant pressure control volume is discussed. Results indicate that the specific impulse of the external burning process rivals that of a turbojet and depends on the severity of the initial base drag as well as on the Mach flight number and the equivalence ratio. A test program was conducted to investigate hydrogen-air flame stability at the conditions of interest and to demonstrate drag reduction on a simple expansion ramp. Initial test results are presented and compared with the control-volume analysis. The expansion ramp surface pressure coefficient showed little variation with fuel pressure and altitude, in disagreement with the analysis. Flame stability results were encouraging and indicate that stable combustion is possible over an adequate range of conditions. Facility interference and chemical kinetics phenomena that make interpretation of subscale ground test data difficult are discussed.

A framework for the interpretation of de novo mutation in human disease

PubMed Central

Samocha, Kaitlin E.; Robinson, Elise B.; Sanders, Stephan J.; Stevens, Christine; Sabo, Aniko; McGrath, Lauren M.; Kosmicki, Jack A.; Rehnström, Karola; Mallick, Swapan; Kirby, Andrew; Wall, Dennis P.; MacArthur, Daniel G.; Gabriel, Stacey B.; dePristo, Mark; Purcell, Shaun M.; Palotie, Aarno; Boerwinkle, Eric; Buxbaum, Joseph D.; Cook, Edwin H.; Gibbs, Richard A.; Schellenberg, Gerard D.; Sutcliffe, James S.; Devlin, Bernie; Roeder, Kathryn; Neale, Benjamin M.; Daly, Mark J.

2014-01-01

Spontaneously arising (‘de novo’) mutations play an important role in medical genetics. For diseases with extensive locus heterogeneity – such as autism spectrum disorders (ASDs) – the signal from de novo mutations (DNMs) is distributed across many genes, making it difficult to distinguish disease-relevant mutations from background variation. We provide a statistical framework for the analysis of DNM excesses per gene and gene set by calibrating a model of de novo mutation. We applied this framework to DNMs collected from 1,078 ASD trios and – while affirming a significant role for loss-of-function (LoF) mutations – found no excess of de novo LoF mutations in cases with IQ above 100, suggesting that the role of DNMs in ASD may reside in fundamental neurodevelopmental processes. We also used our model to identify ~1,000 genes that are significantly lacking functional coding variation in non-ASD samples and are enriched for de novo LoF mutations identified in ASD cases. PMID:25086666

Morphology of the jaw, suspensorial, and opercle musculature of Beloniformes and related species (Teleostei: Acanthopterygii), with a special reference to the m. adductor mandibulae complex.

PubMed

Werneburg, Ingmar

2015-01-01

The taxon Beloniformes represents a heterogeneous group of teleost fishes that show an extraordinary diversity of jaw morphology. I present new anatomical descriptions of the jaw musculature in six selected beloniforms and four closely related species. A reduction of the external jaw adductor (A1) and a changed morphology of the intramandibular musculature were found in many Beloniformes. This might be correlated with the progressively reduced mobility of the upper and lower jaw bones. The needlefishes and sauries, which are characterised by extremely elongated and stiffened jaws, show several derived characters, which in combination enable the capture of fish at high velocity. The ricefishes are characterised by several derived and many plesiomorphic characters that make broad scale comparisons difficult. Soft tissue characters are highly diverse among hemiramphids and flying fishes reflecting the uncertainty about their phylogenetic position and interrelationship. The morphological findings presented herein may help to interpret future phylogenetic analyses using cranial musculature in Beloniformes.

How report cards on physicians, physician groups, and hospitals can have greater impact on consumer choices.

PubMed

Sinaiko, Anna D; Eastman, Diana; Rosenthal, Meredith B

2012-03-01

Public report cards with quality and cost information on physicians, physician groups, and hospital providers have proliferated in recent years. However, many of these report cards are difficult for consumers to interpret and have had little impact on the provider choices consumers are making. To gain a more focused understanding of why these reports cards have not been more successful and what improvements could be made, we interviewed experts and surveyed registrants at the March 2011 AHRQ National Summit on Public Reporting for Consumers in Health Care. We found broad agreement that public reporting has been disconnected from consumer decisions about providers because of weaknesses in report card content, design, and accessibility. Policy makers have an opportunity to change the landscape of public reporting by taking advantage of advances in measurement, data collection, and information technology to deliver a more consumer-centered report card. Overcoming the constraint of limited public funding, and achieving the acceptance of providers, is critical to realizing future success.

Ensoulment and IVF embryos.

PubMed Central

Shea, M C

1987-01-01

This paper examines the metaphysical question of 'ensoulment' in relation to the theory, put forward in an earlier paper, that human life begins when the newly formed body organs and systems of the embryo begin to function as an organised whole, at which stage there is evidence of a change of nature. Although Roman Catholic theology teaches that a human being is a union of physical body and spiritual soul, it is incorrect to interpret this in a dualistic sense. The meaning of 'soul' is considered and the conclusion reached that although both in the religious context and apart from it abortion is difficult to justify at any stage after conception, it does not follow that the use of 'spare' In Vitro Fertilisation (IVF) embryos should be rejected. If 'ensoulment' does not occur until the new organism functions as a whole then a decision not to make use of IVF embryos for medical purposes would be a heavy responsibility and not a 'safe' way out. PMID:3612702

A class of compact dwarf galaxies from disruptive processes in galaxy clusters.

PubMed

Drinkwater, M J; Gregg, M D; Hilker, M; Bekki, K; Couch, W J; Ferguson, H C; Jones, J B; Phillipps, S

2003-05-29

Dwarf galaxies have attracted increased attention in recent years, because of their susceptibility to galaxy transformation processes within rich galaxy clusters. Direct evidence for these processes, however, has been difficult to obtain, with a small number of diffuse light trails and intra-cluster stars being the only signs of galaxy disruption. Furthermore, our current knowledge of dwarf galaxy populations may be very incomplete, because traditional galaxy surveys are insensitive to extremely diffuse or compact galaxies. Aware of these concerns, we recently undertook an all-object survey of the Fornax galaxy cluster. This revealed a new population of compact members, overlooked in previous conventional surveys. Here we demonstrate that these 'ultra-compact' dwarf galaxies are structurally and dynamically distinct from both globular star clusters and known types of dwarf galaxy, and thus represent a new class of dwarf galaxy. Our data are consistent with the interpretation that these are the remnant nuclei of disrupted dwarf galaxies, making them an easily observed tracer of galaxy disruption.

A distal earthquake cluster concurrent with the 2006 explosive eruption of Augustine Volcano, Alaska

USGS Publications Warehouse

Fisher, M.A.; Ruppert, N.A.; White, R.A.; Wilson, Frederic H.; Comer, D.; Sliter, R.W.; Wong, F.L.

2009-01-01

Clustered earthquakes located 25??km northeast of Augustine Volcano began about 6??months before and ceased soon after the volcano's 2006 explosive eruption. This distal seismicity formed a dense cluster less than 5??km across, in map view, and located in depth between 11??km and 16??km. This seismicity was contemporaneous with sharply increased shallow earthquake activity directly below the volcano's vent. Focal mechanisms for five events within the distal cluster show strike-slip fault movement. Cluster seismicity best defines a plane when it is projected onto a northeast-southwest cross section, suggesting that the seismogenic fault strikes northwest. However, two major structural trends intersect near Augustine Volcano, making it difficult to put the seismogenic fault into a regional-geologic context. Specifically, interpretation of marine multichannel seismic-reflection (MCS) data shows reverse faults, directly above the seismicity cluster, that trend northeast, parallel to the regional geologic strike but perpendicular to the fault suggested by the clustered seismicity. The seismogenic fault could be a reactivated basement structure.

The occupational physician's point of view: the model of man-made vitreous fibers.

PubMed Central

Brochard, P; Pairon, J C; Bignon, J

1994-01-01

This article gives a detailed description of the procedure the occupational physician uses in interpreting the available scientific data to provide useful information for prevention of pulmonary diseases related to man-made mineral fibers, particularly lung cancer and mesothelioma. As it is difficult to reach definite conclusions from human data on the toxicity of specific fibers, an experimental approach is needed. Concerning animal data, we emphasize that adequate inhalation studies are the "gold standard" for extrapolating to humans. However, experiments using intracavitary injection or cells in vitro may represent indicative tests for a possible carcinogenic effect. Such tests should be used to assess the intrinsic carcinogenicity of fibers, but they must be confirmed by adequate inhalation models. Despite the present uncertainties, a proposal is made that could make it possible to classify fibers according to their toxicologic potential, grading them in accordance with physicochemical parameters, in vitro testing, and animal experiments. This procedure may be applicable to nonvitreous fibers and to organic fibers. PMID:7882952

Time for a neonatal–specific consensus definition for sepsis

PubMed Central

Wynn, James L.; Wong, Hector R.; Shanley, Thomas P.; Bizzarro, Matthew J.; Saiman, Lisa; Polin, Richard A.

2014-01-01

Objective To review the accuracy of the pediatric consensus definition of sepsis in term neonates and to determine the definition of neonatal sepsis used. Study selection The review focused primarily on pediatric literature relevant to the topic of interest. Conclusions Neonatal sepsis is variably defined based on a number of clinical and laboratory criteria that make the study of this common and devastating condition very difficult. Diagnostic challenges and uncertain disease epidemiology necessarily result from a variable definition of disease. In 2005, intensivists caring for children recognized that as new drugs became available, children would be increasingly studied and thus, pediatric-specific consensus definitions were needed. Pediatric sepsis criteria are not accurate for term neonates and have not been examined in preterm neonates for whom the developmental stage influences aberrations associated with host immune response. Thus, specific consensus definitions for both term and preterm neonates are needed. Such definitions are critical for the interpretation of observational studies, future training of scientists and practitioners, and implementation of clinical trials in neonates. PMID:24751791

[Interpretation of ultrasound findings in otorhinolaryngology. Salivary glands, paraganglioma, angioma, esophagus, hypopharynx, extra cranial vessels and temporomandibular joint].

PubMed

Bozzato, A

2015-06-01

The second part of this continuing medical education article focuses on sonographic assessment of the salivary glands, cervical paraganglioma, angioma, esophagus, extra cranial blood vessels and the temporomandibular joint. The currently available minimally invasive therapeutic options (e. g. sialendoscopy, lithotripsy, therapeutic duct lavage and extracapsular dissection) for salivary gland disease presuppose a precise imaging modality. Modern ultrasound is able to meet this challenge, making additional imaging a rare necessity. Regions of the neck with a difficult topography (esophagus and hypopharynx) can often be successfully portrayed sonographically. Furthermore, ultrasound enables functional evaluation of swallowing in the cervical parts of the esophagus in dysphagia patients. In addition to the branchial cleft anomalies and lymph nodes discussed in part 1, paraganglioma, angiomatosis and neurogenic tumors are important differential diagnoses of solid lesions of the neck. Finally, venous and arterial alterations of the extracranial vessels of the neck relevant to clinical routine are depicted, as are pathological conditions of the temporomandibular joint relevant to the otorhinolaryngologist.

MRI abnormalities of peripheral nerve and muscle are common in amyotrophic lateral sclerosis and share features with multifocal motor neuropathy

PubMed Central

Staff, Nathan P.; Amrami, Kimberly K.; Howe, Benjamin M.

2015-01-01

Introduction MRI of peripheral nerve and muscle in patients with ALS may be performed to investigate alternative diagnoses including multifocal motor neuropathy (MMN). MRI findings of peripheral nerve and muscle are not well described in these conditions, making interpretation of results difficult. Methods We examined systematically the peripheral nerve and muscle MRI findings in patients with ALS (n=60) and MMN (n=8). Results In patients with ALS and MMN, abnormal MRIs were common (85% and 75%, respectively) but did not correlate with disease severity. Peripheral nerve MRI abnormalities were similar in frequency (ALS: 58% vs. MMN: 63%) with most changes being of mild-to-moderate severity. Muscle MRI changes were more common in ALS (57% vs. 33%), and no muscle atrophy was seen in patients with MMN. Discussion MRI abnormalities of peripheral nerve and muscle in ALS and MMN are common and share some features. PMID:25736373

The Future of Contextual Fear Learning for PTSD Research: A Methodological Review of Neuroimaging Studies.

PubMed

Glenn, Daniel E; Risbrough, Victoria B; Simmons, Alan N; Acheson, Dean T; Stout, Daniel M

2017-10-21

There has been a great deal of recent interest in human models of contextual fear learning, particularly due to the use of such paradigms for investigating neural mechanisms related to the etiology of posttraumatic stress disorder. However, the construct of "context" in fear conditioning research is broad, and the operational definitions and methods used to investigate contextual fear learning in humans are wide ranging and lack specificity, making it difficult to interpret findings about neural activity. Here we will review neuroimaging studies of contextual fear acquisition in humans. We will discuss the methodology associated with four broad categories of how contextual fear learning is manipulated in imaging studies (colored backgrounds, static picture backgrounds, virtual reality, and configural stimuli) and highlight findings for the primary neural circuitry involved in each paradigm. Additionally, we will offer methodological recommendations for human studies of contextual fear acquisition, including using stimuli that distinguish configural learning from discrete cue associations and clarifying how context is experimentally operationalized.

Failure Bounding And Sensitivity Analysis Applied To Monte Carlo Entry, Descent, And Landing Simulations

NASA Technical Reports Server (NTRS)

Gaebler, John A.; Tolson, Robert H.

2010-01-01

In the study of entry, descent, and landing, Monte Carlo sampling methods are often employed to study the uncertainty in the designed trajectory. The large number of uncertain inputs and outputs, coupled with complicated non-linear models, can make interpretation of the results difficult. Three methods that provide statistical insights are applied to an entry, descent, and landing simulation. The advantages and disadvantages of each method are discussed in terms of the insights gained versus the computational cost. The first method investigated was failure domain bounding which aims to reduce the computational cost of assessing the failure probability. Next a variance-based sensitivity analysis was studied for the ability to identify which input variable uncertainty has the greatest impact on the uncertainty of an output. Finally, probabilistic sensitivity analysis is used to calculate certain sensitivities at a reduced computational cost. These methods produce valuable information that identifies critical mission parameters and needs for new technology, but generally at a significant computational cost.

Progressive Learning of Topic Modeling Parameters: A Visual Analytics Framework.

PubMed

El-Assady, Mennatallah; Sevastjanova, Rita; Sperrle, Fabian; Keim, Daniel; Collins, Christopher

2018-01-01

Topic modeling algorithms are widely used to analyze the thematic composition of text corpora but remain difficult to interpret and adjust. Addressing these limitations, we present a modular visual analytics framework, tackling the understandability and adaptability of topic models through a user-driven reinforcement learning process which does not require a deep understanding of the underlying topic modeling algorithms. Given a document corpus, our approach initializes two algorithm configurations based on a parameter space analysis that enhances document separability. We abstract the model complexity in an interactive visual workspace for exploring the automatic matching results of two models, investigating topic summaries, analyzing parameter distributions, and reviewing documents. The main contribution of our work is an iterative decision-making technique in which users provide a document-based relevance feedback that allows the framework to converge to a user-endorsed topic distribution. We also report feedback from a two-stage study which shows that our technique results in topic model quality improvements on two independent measures.

Human evolution in the age of the intelligent machine

NASA Astrophysics Data System (ADS)

McLaughlin, W. I.

A systems analysis of the future evolution of man can be conducted by analyzing the biological material of the galaxy into three subsystems: man, intelligent machines, and intelligent extraterrestrial organisms. A binomial interpretation is applied to this system wherein each of the subsystems is assigned a designation of success or failure. For man the two alternatives are, respectively, 'decline' or 'flourish', for machine they are 'become intelligent' or 'stay dumb', while for extraterrestrial intelligence the dichotomy is that of 'existence' or 'nonexistence'. The choices for each of three subsystems yield a total of eight possible states for the system. The relative lack of integration between brain components makes man a weak evolutionary contestant compared to machines. It is judged that machines should become dominant on earth within 100 years, probably by means of continuing development of existing man-machine systems. Advanced forms of extraterrestrial intelligence may exist but are too difficult to observe. The prospects for communication with extraterrestrial intelligence are reviewed.

Ultracold Polar Molecules

DTIC Science & Technology

2016-04-01

large positive scattering lengths make clouds difficult to overlap (but 85RbCs looked promising), but 85RbCs is difficult because 85Rb is hard to...produce at high densities. We revealed broad Feshbach resonances that we hope will allow production of higher-density 85Rb clouds . We are now...and this makes clouds of 87Rb and Cs hard to overlap. We therefore investi- gated 85RbCs, using the potentials we had developed for 85RbCs, and showed

Theorizing "Difficult Knowledge" in the Aftermath of the "Affective Turn": Implications for Curriculum and Pedagogy in Handling Traumatic Representations

ERIC Educational Resources Information Center

Zembylas, Michalinos

2014-01-01

This essay draws on the concept of "difficult knowledge" to think with some of the interventions and arguments of affect theory and discusses the implications for curriculum and pedagogy in handling traumatic representations. The author makes an argument that affect theory enables the theorization of difficult knowledge as an…

An investigation of developmental changes in interpretation and construction of graphic AAC symbol sequences through systematic combination of input and output modalities.

PubMed

Trudeau, Natacha; Sutton, Ann; Morford, Jill P

2014-09-01

While research on spoken language has a long tradition of studying and contrasting language production and comprehension, the study of graphic symbol communication has focused more on production than comprehension. As a result, the relationships between the ability to construct and to interpret graphic symbol sequences are not well understood. This study explored the use of graphic symbol sequences in children without disabilities aged 3;0 to 6;11 (years; months) (n=111). Children took part in nine tasks that systematically varied input and output modalities (speech, action, and graphic symbols). Results show that in 3- and 4-year-olds, attributing meaning to a sequence of symbols was particularly difficult even when the children knew the meaning of each symbol in the sequence. Similarly, while even 3- and 4-year-olds could produce a graphic symbol sequence following a model, transposing a spoken sentence into a graphic sequence was more difficult for them. Representing an action with graphic symbols was difficult even for 5-year-olds. Finally, the ability to comprehend graphic-symbol sequences preceded the ability to produce them. These developmental patterns, as well as memory-related variables, should be taken into account in choosing intervention strategies with young children who use AAC.

Composition in the Quantum World

NASA Astrophysics Data System (ADS)

Hall, Edward Jonathan

This thesis presents a problem for the foundations of quantum mechanics. It arises from the way that theory describes the composition of larger systems in terms of smaller ones, and renders untenable a wide range of interpretations of quantum mechanics. That quantum mechanics is difficult to interpret is old news, given the well-known Measurement Problem. But the problem I raise is quite different, and in important respects more fundamental. In brief: The physical world exhibits mereological structure: physical objects have parts, which in turn have parts, and so on. A natural way to try to represent this structure is by means of a particle theory, according to which the physical world consists entirely enduring physical objects which themselves have no proper parts, but aggregates of which are, or compose, all physical objects. Elementary, non-relativistic quantum mechanics can be cast in this mold--at least, according to the usual expositions of that theory. But herein lies the problem: the standard attempt to give a systematic particle interpretation to elementary quantum mechanics results in nonsense, thanks to the well-established principle of Permutation Invariance, which constrains the quantum -mechanical description of systems containing identical particles. Specifically, it follows from the most minimal principles of a particle interpretation (much weaker than those needed to generate the Measurement Problem), together with Permutation Invariance, that systems identical in composition must have the same physical state. In other words, systems which merely have the same numbers of the same types of particles are therefore, at all times, perfect physical duplicates. This conclusion is absurd: e.g., it is quite plausible that some of those particles which compose my body make up a system identical in composition to some pepperoni pizza. Yet no part of me is a qualitative physical duplicate of any pepperoni pizza. Perhaps "you are what you eat" --but not in this sense! In what follows I develop the principles needed to explore this problem, contrast it with the Measurement Problem, and consider, finally, how it should influence our judgments of the relative merits of the many extant interpretations of quantum mechanics.

Understanding Infants: Characteristics of Early Childhood Practitioners' Interpretations of Infants and Their Behaviours

ERIC Educational Resources Information Center

Degotardi, Sheila; Davis, Belinda

2008-01-01

This research explored the nature of early childhood practitioners' interpretations of infants in their programs on the basis that such interpretations guide practitioner-infant interactions and curriculum decision-making processes. Twenty-four infant practitioners were asked to describe a nominated infant in their program and to interpret video…

Quality of communication in interpreted versus noninterpreted PICU family meetings.

PubMed

Van Cleave, Alisa C; Roosen-Runge, Megan U; Miller, Alison B; Milner, Lauren C; Karkazis, Katrina A; Magnus, David C

2014-06-01

To describe the quality of physician-family communication during interpreted and noninterpreted family meetings in the PICU. Prospective, exploratory, descriptive observational study of noninterpreted English family meetings and interpreted Spanish family meetings in the pediatric intensive care setting. A single, university-based, tertiary children's hospital. Participants in PICU family meetings, including medical staff, family members, ancillary staff, and interpreters. Thirty family meetings (21 English and nine Spanish) were audio-recorded, transcribed, de-identified, and analyzed using the qualitative method of directed content analysis. Quality of communication was analyzed in three ways: 1) presence of elements of shared decision-making, 2) balance between physician and family speech, and 3) complexity of physician speech. Of the 11 elements of shared decision-making, only four occurred in more than half of English meetings, and only three occurred in more than half of Spanish meetings. Physicians spoke for a mean of 20.7 minutes, while families spoke for 9.3 minutes during English meetings. During Spanish meetings, physicians spoke for a mean of 14.9 minutes versus just 3.7 minutes of family speech. Physician speech complexity received a mean grade level score of 8.2 in English meetings compared to 7.2 in Spanish meetings. The quality of physician-family communication during PICU family meetings is poor overall. Interpreted meetings had poorer communication quality as evidenced by fewer elements of shared decision-making and greater imbalance between physician and family speech. However, physician speech may be less complex during interpreted meetings. Our data suggest that physicians can improve communication in both interpreted and noninterpreted family meetings by increasing the use of elements of shared decision-making, improving the balance between physician and family speech, and decreasing the complexity of physician speech.

Some decks are better than others: the effect of reinforcer type and task instructions on learning in the Iowa Gambling Task.

PubMed

Fernie, Gordon; Tunney, Richard J

2006-02-01

The Iowa Gambling Task (Bechara, Damasio, Damasio, & Anderson, 1994) has become widely used as a laboratory test of "real-life" decision-making. However, aspects of its administration that have been varied by researchers may differentially affect performance and the conclusions researchers can draw. Some researchers have used facsimile money reinforcers while others have used real money reinforcers. More importantly, the instructions participants receive have also been varied. While no differences have been reported in performance dependent on reinforcer type, no previous comparison of participants' instructions has been conducted. This is despite one set of instructions giving participants a clear hint about the nature of the task. Additionally, in previous research one set of instructions have not been used exclusively with one reinforcer type making any differential or cumulative effects of these factors difficult to interpret. The present study compared the effects of instruction and reinforcer type on IGT performance. When participants received instructions without a hint performance was affected by reinforcer type. This was not the case when the instructions included a hint. In a second IGT session performance was improved in participants who had received the hint instructions compared with those who had not.

[Patient-centered approaches to understanding, transformation and solution of team conflicts in the psychiatric clinic within the scope of the Balint group concept].

PubMed

Drees, A

1987-08-01

The working climate and therapeutic possibilities in a hospital are determined, among other factors, by emotional processes in everyday ward routine. Team conflicts and their solution are not infrequently reflections of the open-mindedness of a hospital towards the complexity of these processes. However, the complex interlocking of transference processes with rôle-specific and personality-conditioned behaviour patterns makes it more difficult to understand and make use of these emotional processes within the team. We present a specific attempt to working up emotional conflicts in a patient-centred approach via focussing on self-rating of the team workers in respect of mood, feeling tone and imagination. Specific internal Balint groups are the fulcrum. To distinguish this method from the theory of object-directed transference of emotions and constructions of relations, the theoretical basis of this group method is seen in the systemic paradigm with which patient-focussed solution functions are obtained in respect of process orientation and instrumental part functions of the team workers. In this connection it was explored to what extent the following factors can be interpreted as patient-induced phenomena: therapeutic and rôle behaviour, hospital structures and administrative squabbles, internal and external walls of a mental hospital.

Application of the laser capture microdissection technique for molecular definition of skeletal cell differentiation in vivo.

PubMed

Benayahu, Dafna; Socher, Rina; Shur, Irena

2008-01-01

Laser capture microdissection (LCM) method allows selection of individual or clustered cells from intact tissues. This technology enables one to pick cells from tissues that are difficult to study individually, sort the anatomical complexity of these tissues, and make the cells available for molecular analyses. Following the cells' extraction, the nucleic acids and proteins can be isolated and used for multiple applications that provide an opportunity to uncover the molecular control of cellular fate in the natural microenvironment. Utilization of LCM for the molecular analysis of cells from skeletal tissues will enable one to study differential patterns of gene expression in the native intact skeletal tissue with reliable interpretation of function for known genes as well as to discover novel genes. Variability between samples may be caused either by differences in the tissue samples (different areas isolated from the same section) or some variances in sample handling. LCM is a multi-task technology that combines histology, microscopy work, and dedicated molecular biology. The LCM application will provide results that will pave the way toward high throughput profiling of tissue-specific gene expression using Gene Chip arrays. Detailed description of in vivo molecular pathways will make it possible to elaborate on control systems to apply for the repair of genetic or metabolic diseases of skeletal tissues.

[Climacteric--medicalization, minimalization or normalization?].

PubMed

Hovelius, B; Ekström, H; Esseveld, J; Landgren, B M; Vinge, E

2000-12-13

Women's experiences and ideas about the climacteric are not in accord with the biomedical model, in which the climacteric and the menopause are characterized as being a risk factor for various diseases and a cause of "estrogen deficiency", a hormonal disease which is assumed to persist during the rest of life. The biomedical model may lead to medicalization and pathologizing, increasing the subordination of women and making them dependent on the health care system. Women who use hormonal therapy during the climacteric have many characteristics differentiating them from women who do not use such therapy. Thus, epidemiological studies will be difficult to interpret with respect to the long term effects of hormonal therapy. It is argued that the consultation for women of middle-age should be characterized by a holistic view of the woman taking account of her gender identity, life conditions and life situation. Such a view should focus on the woman's own ideas as to diagnostic procedures, treatment and solutions. In view of the lack of knowledge about the pros and cons of hormonal therapy, women themselves should make the decision, and such decisions should be encouraged. Also, the efforts directed towards women's compliance to hormonal therapy can be questioned. Women's climacteric symptoms should neither be medicalized, pathologized or minimized.

Stochastic simulation of ecohydrological interactions between vegetation and groundwater

NASA Astrophysics Data System (ADS)

Dwelle, M. C.; Ivanov, V. Y.; Sargsyan, K.

2017-12-01

The complex interactions between groundwater and vegetation in the Amazon rainforest may yield vital ecophysiological interactions in specific landscape niches such as buffering plant water stress during dry season or suppression of water uptake due to anoxic conditions. Representation of such processes is greatly impacted by both external and internal sources of uncertainty: inaccurate data and subjective choice of model representation. The models that can simulate these processes are complex and computationally expensive, and therefore make it difficult to address uncertainty using traditional methods. We use the ecohydrologic model tRIBS+VEGGIE and a novel uncertainty quantification framework applied to the ZF2 watershed near Manaus, Brazil. We showcase the capability of this framework for stochastic simulation of vegetation-hydrology dynamics. This framework is useful for simulation with internal and external stochasticity, but this work will focus on internal variability of groundwater depth distribution and model parameterizations. We demonstrate the capability of this framework to make inferences on uncertain states of groundwater depth from limited in situ data, and how the realizations of these inferences affect the ecohydrological interactions between groundwater dynamics and vegetation function. We place an emphasis on the probabilistic representation of quantities of interest and how this impacts the understanding and interpretation of the dynamics at the groundwater-vegetation interface.

Late-night salivary cortisol measurement in the diagnosis of Cushing's syndrome.

PubMed

Carroll, Ty; Raff, Hershel; Findling, James W

2008-06-01

Making a definite diagnosis of Cushing's syndrome is a challenging problem. Unsuspected Cushing's syndrome occurs in 2-3% of patients with poorly controlled diabetes, 0.5-1% with hypertension, 6-9% with incidental adrenal masses, and 11% with unexplained osteoporosis and vertebral fractures. The increasing recognition of this syndrome highlights the need for a simple, sensitive, and specific diagnostic test. Patients with Cushing's syndrome consistently do not reach a normal nadir of cortisol secretion at night. The measurement of late-night salivary cortisol levels might, therefore, provide a new diagnostic approach for this disorder. Salivary cortisol concentrations reflect those of active free cortisol in plasma and saliva samples can easily be obtained in a nonstressful environment (e.g. at home). Late-night salivary cortisol measurement yields excellent overall diagnostic accuracy for Cushing's syndrome, with a sensitivity of 92-100% and a specificity of 93-100%. Several factors can, however, make interpretation of results difficult; these factors include disturbed sleep-wake cycles, contamination of samples (particularly by topical corticosteroids), and illnesses known to cause physiologic activation of the pituitary-adrenal axis. In this Review, we discuss the methods and value of measuring salivary cortisol for the diagnosis of Cushing's syndrome, and put forward some recommendations to maximize accuracy of results.

Multiscale approach to the determination of the photoactive yellow protein signaling state ensemble.

PubMed

A Rohrdanz, Mary; Zheng, Wenwei; Lambeth, Bradley; Vreede, Jocelyne; Clementi, Cecilia

2014-10-01

The nature of the optical cycle of photoactive yellow protein (PYP) makes its elucidation challenging for both experiment and theory. The long transition times render conventional simulation methods ineffective, and yet the short signaling-state lifetime makes experimental data difficult to obtain and interpret. Here, through an innovative combination of computational methods, a prediction and analysis of the biological signaling state of PYP is presented. Coarse-grained modeling and locally scaled diffusion map are first used to obtain a rough bird's-eye view of the free energy landscape of photo-activated PYP. Then all-atom reconstruction, followed by an enhanced sampling scheme; diffusion map-directed-molecular dynamics are used to focus in on the signaling-state region of configuration space and obtain an ensemble of signaling state structures. To the best of our knowledge, this is the first time an all-atom reconstruction from a coarse grained model has been performed in a relatively unexplored region of molecular configuration space. We compare our signaling state prediction with previous computational and more recent experimental results, and the comparison is favorable, which validates the method presented. This approach provides additional insight to understand the PYP photo cycle, and can be applied to other systems for which more direct methods are impractical.

Addressing the "other" health literacy competencies--knowledge, dispositions, and oral/aural communication: development of TALKDOC, an intervention assessment tool.

PubMed

Helitzer, Deborah; Hollis, Christine; Sanders, Margaret; Roybal, Suzanne

2012-01-01

Most health literacy assessments evaluate literacy skills including reading, writing; numeracy and interpretation of tables, graphs, diagrams and charts. Some assess understanding of health systems, and the ability to adequately apply one's skills to specific health-related tasks or demands in health situations. However, to achieve functional health literacy, the ability to "obtain, process, and understand basic health information and services needed to make appropriate health decisions," other health literacy dimensions should be assessed: a person's knowledge and attitudes about a health issue affects his or her ability to and interest in participating in his or her own care. In patient care settings, the abilities to listen, ask questions and check one's understanding are crucial to making appropriate decisions and carrying out instructions. Although literacy is a skill associated with educational attainment and therefore difficult to change in a short time, health education interventions can address health literacy domains such as knowledge, attitudes and oral communication skills. For this reason, an instrument that can assess these constructs is a valuable part of a health educator's toolbox. The authors describe the development and process and outcomes of testing a novel instrument targeted to assess HPV and cervical cancer health literacy competencies, TALKDOC, including its validation with the Health Activities Literacy Scale.

Fluorescence from graphene oxide and the influence of ionic, π-π interactions and heterointerfaces: electron or energy transfer dynamics.

PubMed

Vempati, Sesha; Uyar, Tamer

2014-10-21

2D crystals such as graphene and its oxide counterpart have sought good research attention for their application as well as fundamental interest. Especially graphene oxide (GO) is quite interesting because of its versatility and diverse application potential. However the mechanism of fluorescence from GO is under severe discussion. To explain the emission in general two interpretations were suggested, viz localization of sp(2) clusters and involvement of oxygeneous functional groups. Despite this disagreement, it should be acknowledged that the heterogeneous atomic structure, synthesis dependent and uncontrollable implantation of oxygen functional groups on the basal plane make such explanations more difficult. Nevertheless, a suitable explanation enhances the applicability of the material which also enables the design of novel materials. At this juncture we believe that given the complexity in understanding the emission mechanism it would be very useful to review the literature. In this perspective we juxtapose various results related to fluorescence and influencing factors so that a conclusive interpretation may be unveiled. Apparently, the existing interpretations have largely ignored the factors such as self-rolling, byproduct formation etc. Vis-a-vis previous reviews did not discuss the interfacial charge transfer across heterostructures and the implication on the optical properties of GO or reduced graphene oxide (rGO). Such analysis would be very insightful to determine the energetic location of sub band gap states. Moreover, ionic and π-π type interactions are also considered for their influence on emission properties. Apart from these, quantum dots, covalent modifications and nonlinear optical properties of GO and rGO were discussed for completeness. Finally we made concluding remarks with outlook.

Social perception in children with intellectual disabilities: the interpretation of benign and hostile intentions.

PubMed

Leffert, J S; Siperstein, G N; Widaman, K F

2010-02-01

A key aspect of social perception is the interpretation of others' intentions. Children with intellectual disabilities (IDs) have difficulty interpreting benign intentions when a negative event occurs. From a cognitive processing perspective, interpreting benign intentions can be challenging because it requires integration of conflicting information, as the social cues accompanying the negative event convey non-hostile intentions. The present study examined how children with ID process conflicting social information in a more diverse set of situational circumstances than was investigated previously, including situations involving hostile intentions. We hypothesised that when conflicting information in a social situation consists of mixed social cues that convey insincere benign intentions (a type of hostile intentions), children with ID would have difficulty arriving at an accurate interpretation, just as they do when a negative event is accompanied by cues that convey benign intentions. We also hypothesised that when a negative event is accompanied by cues that convey benign intentions, the presence of a highly salient negative event would pose added interpretation difficulty for these children. Methods Participants (58 children with ID and 189 children without ID in grades 2-6) viewed 13 videotaped vignettes. In each vignette, social cues that accompanied a negative event provided information about the intentions of the character that caused the event. After presenting each vignette, we asked the child questions designed to assess aspects of social perception, including his/her interpretation of intentions. Vignettes represented three types of situations that pose conflicting information: (1) a conflict between a negative event and social cues, which conveyed benign intentions (five items); (2) the presence of conflicting social cues that conveyed insincere benign intentions (four items); and (3) additional items designed to examine the effect of the salience of negative event and cues on accurate interpretation of benign intentions (four items). Teachers completed rating scales of social behaviour, enabling us to examine whether the ability to interpret intentions when conflicting information is present is related to children's social behaviour. Results Children with ID had lower interpretation accuracy than children without ID for all three social situations that presented conflicting information. Children with ID appeared to have particular difficulty interpreting benign intentions when a negative event (but not the social cue) was made salient. For children with ID, interpretation accuracy and teacher-rated social behaviour were related. Conclusions Results demonstrated that the presence of conflicting information poses cognitive processing challenges in a variety of social situations, making it difficult for children with ID to arrive at accurate interpretations. Children with ID were less likely than children without ID to interpret intentions accurately, not just when the social cues conveyed benign intentions, but also when mixed social cues conveyed hostile intentions. In addition, when social cues accompanying a negative event convey benign intentions, the relative salience of the negative event and the cues can affect interpretation accuracy for children with ID. Discussion focuses on implications for understanding the cognitive component of the social domain of adaptive behaviour, for explaining gullibility in children with ID and for instructional practices.

78 FR 58160 - Certification Process for State Capital Counsel System

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-23

... make such independent assessments in the context of making certification decisions under chapter 154... decisions concerning the objectives of representation,'' ABA Model Rule 1.2(a), making it difficult to... certification procedures. The Attorney General determined that chapter 154 gave him greater discretion in making...

Widening Possibilities of Interpretation When Observing Learning and Teaching through the Use of a Dynamic Visual Notation

ERIC Educational Resources Information Center

Kell, Clare; Sweet, John

2017-01-01

This paper shows how peer observation of learning and teaching (POLT) discussions can be augmented through the use of a dynamic visual notation that makes visible for interpretation, elements of teacher-learner and learner-earner nonverbal interactions. Making visible the nonverbal, physical, spatial and kinesics (eye-based) elements of…

Looking for Ideas: Observation, Interpretation and Hypothesis-Making by 12-Year-Old Pupils Undertaking Science Investigations.

ERIC Educational Resources Information Center

Tomkins, Stephen P.; Tunnicliffe, Sue Dale

2001-01-01

Studies English comprehensive secondary school students' interpretation and hypothesis-making while 12 year-old students are observing a bottle ecosystem of brine shrimps without any prior instruction and keeping diaries. Studies students through the task of open-ended diary writing and through small group discussions about the scientific…

Making Payton's Rocket: Heterotopia and Lines of Flight

ERIC Educational Resources Information Center

MacRae, Christina

2011-01-01

This article explores the potential of heterotopia as a way to prompt us to think differently about children's art-making. Foucault uses the term to describe a space of difference. As something that is not easily located within a system of representation, a heterotopia is not amenable to interpretation. It is this resistance to interpretation that…

Developing a Tele-Robotic Platform for Bridge Inspection

DOT National Transportation Integrated Search

2011-05-01

There are many bridges in Virginia with high traffic volumes or difficult access conditions which make these bridges difficult and expensive to inspect. In addition, the inspection of many bridges exposes the inspectors to hazardous conditions such a...

eMovie: a storyboard-based tool for making molecular movies.

PubMed

Hodis, Eran; Schreiber, Gideon; Rother, Kristian; Sussman, Joel L

2007-05-01

The 3D structures of macromolecules are difficult to grasp and also to communicate. By their nature, movies or animations are particularly useful for highlighting key features by offering a 'guided tour' of structures and conformation changes. However, high-quality movies are rarely seen because they are currently difficult and time consuming to make. By adopting the traditional movie 'storyboard' concept, which gives guidance and direction to filming, eMovie makes the creation of lengthy molecular animations much easier. This tool is a plug-in for the open-source molecular graphics program PyMOL, and enables experts and novices alike to produce informative and high-quality molecular animations.

[Diagnosis and treatment guidelines for difficult-to-control asthma in children].

PubMed

Navarro Merino, M; Andrés Martín, A; Asensio de la Cruz, O; García García, M L; Liñán Cortes, S; Villa Asensi, J R

2009-12-01

Children suffering from difficult-to-control asthma (DCA) require frequent appointments with their physician, complex treatment regimes and often admissions to hospital. Less than 5% of the asthmatic population suffer this condition. DCA must be correctly characterised to rule out false causes of DCA and requires making a differential diagnosis from pathologies that mimic asthma, comorbidity, environmental and psychological factors, and analysing the factors to determine poor treatment compliance. In true DCA cases, inflammation studies (exhaled nitric oxide, induced sputum, broncho-alveolar lavage and bronchial biopsy), pulmonary function and other clinical aspects can classify DCA into different phenotypes which could make therapeutic decision-making easier.

Inference from the small scales of cosmic shear with current and future Dark Energy Survey data

DOE PAGES

MacCrann, N.; Aleksić, J.; Amara, A.; ...

2016-11-05

Cosmic shear is sensitive to fluctuations in the cosmological matter density field, including on small physical scales, where matter clustering is affected by baryonic physics in galaxies and galaxy clusters, such as star formation, supernovae feedback and AGN feedback. While muddying any cosmological information that is contained in small scale cosmic shear measurements, this does mean that cosmic shear has the potential to constrain baryonic physics and galaxy formation. We perform an analysis of the Dark Energy Survey (DES) Science Verification (SV) cosmic shear measurements, now extended to smaller scales, and using the Mead et al. 2015 halo model tomore » account for baryonic feedback. While the SV data has limited statistical power, we demonstrate using a simulated likelihood analysis that the final DES data will have the statistical power to differentiate among baryonic feedback scenarios. We also explore some of the difficulties in interpreting the small scales in cosmic shear measurements, presenting estimates of the size of several other systematic effects that make inference from small scales difficult, including uncertainty in the modelling of intrinsic alignment on nonlinear scales, `lensing bias', and shape measurement selection effects. For the latter two, we make use of novel image simulations. While future cosmic shear datasets have the statistical power to constrain baryonic feedback scenarios, there are several systematic effects that require improved treatments, in order to make robust conclusions about baryonic feedback.« less

The color of complexes and UV-vis spectroscopy as an analytical tool of Alfred Werner's group at the University of Zurich.

PubMed

Fox, Thomas; Berke, Heinz

2014-01-01

Two PhD theses (Alexander Gordienko, 1912; Johannes Angerstein, 1914) and a dissertation in partial fulfillment of a PhD thesis (H. S. French, Zurich, 1914) are reviewed that deal with hitherto unpublished UV-vis spectroscopy work of coordination compounds in the group of Alfred Werner. The method of measurement of UV-vis spectra at Alfred Werner's time is described in detail. Examples of spectra of complexes are given, which were partly interpreted in terms of structure (cis ↔ trans configuration, counting number of bands for structural relationships, and shift of general spectral features by consecutive replacement of ligands). A more complete interpretation of spectra was hampered at Alfred Werner's time by the lack of a light absorption theory and a correct theory of electron excitation, and the lack of a ligand field theory for coordination compounds. The experimentally difficult data acquisitions and the difficult spectral interpretations might have been reasons why this method did not experience a breakthrough in Alfred Werner's group to play a more prominent role as an important analytical method. Nevertheless the application of UV-vis spectroscopy on coordination compounds was unique and novel, and witnesses Alfred Werner's great aptitude and keenness to always try and go beyond conventional practice.

Hidden Markov Models as a tool to measure pilot attention switching during simulated ILS approaches

DOT National Transportation Integrated Search

2003-04-14

The pilot's instrument scanning data contain information about not only the pilot's eye movements, but also the pilot's : cognitive process during flight. However, it is often difficult to interpret the scanning data at the cognitive level : because:...

Constructive Ontology Engineering

ERIC Educational Resources Information Center

Sousan, William L.

2010-01-01

The proliferation of the Semantic Web depends on ontologies for knowledge sharing, semantic annotation, data fusion, and descriptions of data for machine interpretation. However, ontologies are difficult to create and maintain. In addition, their structure and content may vary depending on the application and domain. Several methods described in…

Enhancing Undergraduate Chemistry Learning by Helping Students Make Connections among Multiple Graphical Representations

ERIC Educational Resources Information Center

Rau, Martina A.

2015-01-01

Multiple representations are ubiquitous in chemistry education. To benefit from multiple representations, students have to make connections between them. However, connection making is a difficult task for students. Prior research shows that supporting connection making enhances students' learning in math and science domains. Most prior research…

Remote Sensing of Aerosols from Satellites: Why Has It Been Do Difficult to Quantify Aerosol-Cloud Interactions for Climate Assessment, and How Can We Make Progress?

NASA Technical Reports Server (NTRS)

Kahn, Ralph A.

2015-01-01

The organizers of the National Academy of Sciences Arthur M. Sackler Colloquia Series on Improving Our Fundamental Understanding of the Role of Aerosol-Cloud Interactions in the Climate System would like to post Ralph Kahn's presentation entitled Remote Sensing of Aerosols from Satellites: Why has it been so difficult to quantify aerosol-cloud interactions for climate assessment, and how can we make progress? to their public website.

Alphabet soup: making sense of genetic testing in CMT.

PubMed

Lawson, Victoria; Gharibshahi, Shahram

2010-09-01

The diagnosis of inherited neuropathies can be challenging in several ways. First, a hereditary neuropathy must be suspected. Although some family histories are clear with multiple members affected, other families require directed inquiry. Second, even when a hereditary neuropathy is clear, it can be difficult to make a genetic characterization. The field of genotyping is expanding so rapidly, it is difficult to know what tests to order. The authors share their guidelines for the diagnosis of inherited neuropathies. © Thieme Medical Publishers.

User's guide to the LLL BASIC interpreter. [For 8080-based MCS-80 microcomputer system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Allison, T.; Eckard, R.; Barber, J.

1977-06-09

Scientists are finding increased applications for microcomputers as process controllers in their experiments. However, while microcomputers are small and inexpensive, they are difficult to program in machine or assembly language. A high-level language is needed to enable scientists to develop their own microcomputer programs for their experiments on location. Recognizing this need, LLL contracted to have such a language developed. This report describes the result--the LLL BASIC interpreter, which operates with LLL's 8080-based MCS-80 microcomputer system. 4 tables.

What is a natural wildfire regime in the Mediterranean? A comparison of Holocene and Eemian fire history at Ioannina, Greece

NASA Astrophysics Data System (ADS)

Lawson, Ian; Venevsky, Sergey; Sitch, Stephen; Tzedakis, Pc; Roucoux, Kh; Frogley, Mr

2010-05-01

Wildfire is an important element of the Earth system, responsible to a large extent for determining vegetation structure, contributing to global carbon cycling, and destructive of human life and property. Understanding wildfire behaviour can help us to predict how fire regimes are likely to change in future and to devise appropriate management strategies. One challenge in studying wildfire is to unpick the relative importance of human activity as a factor; in many densely-populated areas of the world, such as the Mediterranean, the majority of vegetation fires are thought to be started accidentally or deliberately by people. This makes it difficult to establish whether the fire frequency and/or intensity experienced today are unusual, in historical terms; whether ecosystems are in equilibrium with modern fire regimes, or are in the process of adjusting to them; and it makes it difficult to determine what an "appropriate" level of burning should be, given that complete elimination of fire is likely in the long run to be detrimental to plant communities that have evolved in environments where burning occurred naturally. Here we present new data from a lake sediment sequence from Lake Ioannina in NW Greece. The sequence contains varying amounts of charcoal, which can be interpreted as a proxy for the intensity and/or frequency of burning in the lake's catchment. Sub-fossil pollen allow us to reconstruct past vegetation communities, and stable isotope data provide some indication of local variations in past climate, supplemented by regional syntheses of other palaeoclimatic data and results of climate modelling experiments. The sediment sequence spans several interglacial-glacial cycles. Here we compare the charcoal, pollen and stable isotope records of the present interglacial, the Holocene, with the last interglacial, the Eemian. Although there are some known climatic differences between the two periods, the overwhelming difference between them is that hominin activity is thought to have been much more limited during the Eemian: the archaeological record from Greece before c. 40,000 years ago is exceedingly sparse, suggesting very little human activity. We argue therefore that the Eemian record can be used to give a reasonably good indication of what modern vegetation and fire conditions might be like without human influence. A detailed interpretation of the interaction between climate, vegetation and fire regime, informed by insights from the fire modules of the LPJ dynamic global vegetation model, provides further assessment of the main controls on Mediterranean fire regimes both with and without significant human influence.

Interpreting Character Emotions for Literature Comprehension.

ERIC Educational Resources Information Center

Barton, James

1996-01-01

Argues that readers learn about emotions from stories, and emotional awareness helps readers understand stories. Offers four instructional approaches for interpreting emotions. Discusses how to find clues to characters' emotions; emotional complexity; how to use emotional information; and interpreting emotions to make connections. (SR)

Working with the Hmong Population in a Genetics Setting: an Interpreter Perspective.

PubMed

Krieger, Meghan; Agather, Aime; Douglass, Kathryn; Reiser, Catherine A; Petty, Elizabeth M

2018-06-01

The aim of this pilot qualitative study was to describe the experiences and beliefs of medical interpreters when working with genetic counselors and other genetic providers caring for Hmong patients who are not native English speakers. Specific goals were to identify interpreters' thoughts and perceptions on (a) their roles during sessions, (b) unique challenges in a genetics session, (c) knowledge genetics providers need when working with Hmong patients and interpreters, and (d) supports and training needed to effectively interpret in a genetics setting. Hmong medical interpreters from Wisconsin and Minnesota were invited by email to participate in the study. Six were interviewed by telephone. Participants had worked with a variety of providers including geneticists, genetic counselors, primary care physicians, and oncologists. Factors identified by Hmong interpreters that made interpretation of content difficult in clinical genetics sessions included: time constraints, technical terms, and unique cultural perspectives of Hmong patients. While all respondents felt their primary role was to interpret session content as close to verbatim as possible, there was notable variation in the description of their interpretation style and other perceived roles in the genetic counseling session. Cultural issues genetics providers could consider when working with Hmong patients and different style issues when working with Hmong interpreters are discussed. Ideas for future studies and suggestions to improve communication with Hmong patients are explored.

An Inquiry-Oriented Curriculum in Map Making and Map Interpretation for the Intermediate Grades.

ERIC Educational Resources Information Center

Janeway, W. Whitney

This publication contains class activities and provocative inquiry questions for intermediate-grade teachers to use to involve students in map making and map interpretation. The author believes that the only things that are needed to develop an inquiry-oriented unit on mapping are a good map, a small group of students, and a perceptive teacher who…

Diffusion Modelling Reveals the Decision Making Processes Underlying Negative Judgement Bias in Rats.

PubMed

Hales, Claire A; Robinson, Emma S J; Houghton, Conor J

2016-01-01

Human decision making is modified by emotional state. Rodents exhibit similar biases during interpretation of ambiguous cues that can be altered by affective state manipulations. In this study, the impact of negative affective state on judgement bias in rats was measured using an ambiguous-cue interpretation task. Acute treatment with an anxiogenic drug (FG7142), and chronic restraint stress and social isolation both induced a bias towards more negative interpretation of the ambiguous cue. The diffusion model was fit to behavioural data to allow further analysis of the underlying decision making processes. To uncover the way in which parameters vary together in relation to affective state manipulations, independent component analysis was conducted on rate of information accumulation and distances to decision threshold parameters for control data. Results from this analysis were applied to parameters from negative affective state manipulations. These projected components were compared to control components to reveal the changes in decision making processes that are due to affective state manipulations. Negative affective bias in rodents induced by either FG7142 or chronic stress is due to a combination of more negative interpretation of the ambiguous cue, reduced anticipation of the high reward and increased anticipation of the low reward.

The effect of variation in interpretation of the La Trobe radiographic foot atlas on the prevalence of foot osteoarthritis in older women: the Chingford general population cohort.

PubMed

McQueen, Peter; Gates, Lucy; Marshall, Michelle; Doherty, Michael; Arden, Nigel; Bowen, Catherine

2017-01-01

The prevalence of foot osteoarthritis (OA) is much less understood than hip, knee and hand OA. The foot is anatomically complex and different researchers have investigated different joints with lack of methodological standardisation across studies. The La Trobe Foot Atlas (LFA) is the first to address these issues in providing quantitative assessment of radiographic foot OA, but has not been tested externally. The aim of this study was to evaluate three different interpretive approaches to using the LFA for grading OA when scoring is difficult due to indistinct views of interosseous space and joint contour. Foot radiographs of all remaining participants ( n  = 218) assessed in the Chingford Women Study 23 year visit (mean (SD) for age: 75.5 years (5.1)) were scored using the LFA defined protocol (Technique 1). Two revised scoring strategies were applied to the radiographs in addition to the standard LFA analyses. Technique 2 categorised joints that were difficult to grade as 'missing'. Technique 3 included joints that were difficult to grade as an over estimated score. Radiographic OA prevalence was defined for the foot both collectively and separately for individual joints. When radiographs were scored using the LFA (Technique 1), radiographic foot OA was present in 89.9%. For Technique 2 the presence of radiographic foot OA was 83.5% and for Technique 3 it was 97.2%. At the individual joint level, using Technique 1, the presence of radiographic foot OA was higher with a wider range (18.3-74.3%) than Technique 2 (17.9-46.3%) and lower with a wider range (18.3-74.3%) than Technique 3 (39.9-79.4%). The three different ways of interpreting the LFA scoring system when grading of individual joints is technically difficult and result in very different estimates of foot OA prevalence at both the individual joint and global foot level. Agreement on the best strategy is required to improve comparability between studies.

Interpretation of way-finding healthcare symbols by a multicultural population: navigation signage design for global health.

PubMed

Hashim, Muhammad Jawad; Alkaabi, Mariam Salem Khamis Matar; Bharwani, Sulaiman

2014-05-01

The interpretation of way-finding symbols for healthcare facilities in a multicultural community was assessed in a cross-sectional study. One hundred participants recruited from Al Ain city in the United Arab Emirates were asked to interpret 28 healthcare symbols developed at Hablamos Juntos (such as vaccinations and laboratory) as well as 18 general-purpose symbols (such as elevators and restrooms). The mean age was 27.6 years (16-55 years) of whom 84 (84%) were females. Healthcare symbols were more difficult to comprehend than general-purpose signs. Symbols referring to abstract concepts were the most misinterpreted including oncology, diabetes education, outpatient clinic, interpretive services, pharmacy, internal medicine, registration, social services, obstetrics and gynecology, pediatrics and infectious diseases. Interpretation rates varied across cultural backgrounds and increased with higher education and younger age. Signage within healthcare facilities should be tested among older persons, those with limited literacy and across a wide range of cultures. Copyright © 2013 Elsevier Ltd and The Ergonomics Society. All rights reserved.

Interpretations of Probability in Quantum Mechanics: A Case of "Experimental Metaphysics"

NASA Astrophysics Data System (ADS)

Hellman, Geoffrey

After reviewing paradigmatic cases of "experimental metaphysics" basing inferences against local realism and determinism on experimental tests of Bells theorem (and successors), we concentrate on clarifying the meaning and status of "objective probability" in quantum mechanics. The terms "objective" and "subjective" are found ambiguous and inadequate, masking crucial differences turning on the question of what the numerical values of probability functions measure vs. the question of the nature of the "events" on which such functions are defined. This leads naturally to a 2×2 matrix of types of interpretations, which are then illustrated with salient examples. (Of independent interest are the splitting of "Copenhagen interpretation" into "objective" and "subjective" varieties in one of the dimensions and the splitting of Bohmian hidden variables from (other) modal interpretations along that same dimension.) It is then explained why Everett interpretations are difficult to categorize in these terms. Finally, we argue that Bohmian mechanics does not seriously threaten the experimental-metaphysical case for ultimate randomness and purely physical probabilities.

Differences in spirometry interpretation algorithms: influence on decision making among primary-care physicians.

PubMed

He, Xiao-Ou; D'Urzo, Anthony; Jugovic, Pieter; Jhirad, Reuven; Sehgal, Prateek; Lilly, Evan

2015-03-12

Spirometry is recommended for the diagnosis of asthma and chronic obstructive pulmonary disease (COPD) in international guidelines and may be useful for distinguishing asthma from COPD. Numerous spirometry interpretation algorithms (SIAs) are described in the literature, but no studies highlight how different SIAs may influence the interpretation of the same spirometric data. We examined how two different SIAs may influence decision making among primary-care physicians. Data for this initiative were gathered from 113 primary-care physicians attending accredited workshops in Canada between 2011 and 2013. Physicians were asked to interpret nine spirograms presented twice in random sequence using two different SIAs and touch pad technology for anonymous data recording. We observed differences in the interpretation of spirograms using two different SIAs. When the pre-bronchodilator FEV1/FVC (forced expiratory volume in one second/forced vital capacity) ratio was >0.70, algorithm 1 led to a 'normal' interpretation (78% of physicians), whereas algorithm 2 prompted a bronchodilator challenge revealing changes in FEV1 that were consistent with asthma, an interpretation selected by 94% of physicians. When the FEV1/FVC ratio was <0.70 after bronchodilator challenge but FEV1 increased >12% and 200 ml, 76% suspected asthma and 10% suspected COPD using algorithm 1, whereas 74% suspected asthma versus COPD using algorithm 2 across five separate cases. The absence of a post-bronchodilator FEV1/FVC decision node in algorithm 1 did not permit consideration of possible COPD. This study suggests that differences in SIAs may influence decision making and lead clinicians to interpret the same spirometry data differently.

Multiculturalism: Beyond Food, Festival, Folklore, and Fashion

ERIC Educational Resources Information Center

Meyer, Calvin F.; Rhoades, Elizabeth Kelley

2006-01-01

Despite overall trends toward increasing student diversity, geographic areas in the United States vary widely in their ethnic composition. In areas where the population is predominately European American, grasping a realistic meaning of "multiculturalism" can be difficult. Often, interpretations of the concept result in a mix of…

PubMed Central

Grégoire, J.

1993-01-01

Between five and 20% of preschool age children have language problems. These can be related to the child's hearing, socioeconomic status, intellectual development, or a psychiatric disorder. Even when it is difficult to recommend a formal screening program, family physicians can interpret delays in speech and language as "indicators" of underlying disorders. PMID:8495143

Continued pheromone release by boll weevils (Coleoptera: curculionidae) following host removal

USDA-ARS?s Scientific Manuscript database

Pheromone traps are a key component of management and eradication programs directed against the boll weevil, Anthonomus grandis (Boheman), but trap data remain difficult to interpret because of the day-to-day variability in captures. Our prior observations suggested a substantial proportion of boll...

Litter accumulation and nutrient content of roadside plant communities in Sichuan Basin, China

USDA-ARS?s Scientific Manuscript database

It is widely recognized that plant community composition strongly influences plant litter, but this relationship is difficult to interpret over heterogeneous conditions typical of modified environments such as roadways. We characterized litter accumulation and nutrient content (i.e., organic C, tota...

Use of interpreters in individual psychotherapy.

PubMed

Baxter, H; Cheng, L Y

1996-02-01

This paper was written after one of the authors treated a case by individual therapy using an interpreter, as patient and therapist spoke different languages. There is little literature on this subject, and this paper describes our findings and recommendations for using this approach. A 15-year-old Chinese, Cantonese-speaking in-patient in Hong Kong was treated with individual psychodynamic psychotherapy by an English-speaking Caucasian psychotherapist. The Chinese interpreter attended each session, and therapy was supervised by a bilingual Chinese supervisor. The alternative was to not carry out any therapy, as there was no other therapist available. The patient was treated for a total of 32 sessions. Issues involving language and culture differences between therapist and patient, issues of therapy in a triadic situation involving group dynamics, and specific therapy difficulties raised by the presence of the interpreter are discussed. Therapy was not as effective as hoped, but the patient made some improvements. Finding a suitable interpreter is difficult and their role must be well defined. A bilingual supervisor is also needed to monitor the translation as well as supervising the therapist. Psychotherapy through an interpreter is feasible but not ideal.

The Mental Status Expert (MSE): an expert system for scoring and interpreting the mental status examination.

PubMed Central

Hier, D. B.; Jao, C. S.; Brint, S. U.

1994-01-01

The mental status examination is the most difficult and time-consuming portion of the neurological examination. A complete mental status examination requires the examiner to assess alertness, memory, language, praxis, gnosis, attention, and visual-spatial functions. Findings of the mental status need to be interpreted in terms of severity of deficits, nature of the deficits, likely etiology, and likely area of corresponding brain injury. The performance of an accurate, complete, and detailed mental status examination is a daunting task for the medical student or resident in training. Traditional mental status examinations show considerable inter-examiner variability for items administered and for interpretation of abnormalities. Even in academic settings, mental status examinations have little educational content. PMID:7949891

Prominence oscillations

NASA Astrophysics Data System (ADS)

Arregui, Iñigo; Oliver, Ramón; Ballester, José Luis

2018-04-01

Prominences are intriguing, but poorly understood, magnetic structures of the solar corona. The dynamics of solar prominences has been the subject of a large number of studies, and of particular interest is the study of prominence oscillations. Ground- and space-based observations have confirmed the presence of oscillatory motions in prominences and they have been interpreted in terms of magnetohydrodynamic waves. This interpretation opens the door to perform prominence seismology, whose main aim is to determine physical parameters in magnetic and plasma structures (prominences) that are difficult to measure by direct means. Here, we review the observational information gathered about prominence oscillations as well as the theoretical models developed to interpret small and large amplitude oscillations and their temporal and spatial attenuation. Finally, several prominence seismology applications are presented.

Brain regions involved in observing and trying to interpret dog behaviour.

PubMed

Desmet, Charlotte; van der Wiel, Alko; Brass, Marcel

2017-01-01

Humans and dogs have interacted for millennia. As a result, humans (and especially dog owners) sometimes try to interpret dog behaviour. While there is extensive research on the brain regions that are involved in mentalizing about other peoples' behaviour, surprisingly little is known of whether we use these same brain regions to mentalize about animal behaviour. In this fMRI study we investigate whether brain regions involved in mentalizing about human behaviour are also engaged when observing dog behaviour. Here we show that these brain regions are more engaged when observing dog behaviour that is difficult to interpret compared to dog behaviour that is easy to interpret. Interestingly, these results were not only obtained when participants were instructed to infer reasons for the behaviour but also when they passively viewed the behaviour, indicating that these brain regions are activated by spontaneous mentalizing processes.

Brain regions involved in observing and trying to interpret dog behaviour

PubMed Central

Desmet, Charlotte; van der Wiel, Alko; Brass, Marcel

2017-01-01

Humans and dogs have interacted for millennia. As a result, humans (and especially dog owners) sometimes try to interpret dog behaviour. While there is extensive research on the brain regions that are involved in mentalizing about other peoples’ behaviour, surprisingly little is known of whether we use these same brain regions to mentalize about animal behaviour. In this fMRI study we investigate whether brain regions involved in mentalizing about human behaviour are also engaged when observing dog behaviour. Here we show that these brain regions are more engaged when observing dog behaviour that is difficult to interpret compared to dog behaviour that is easy to interpret. Interestingly, these results were not only obtained when participants were instructed to infer reasons for the behaviour but also when they passively viewed the behaviour, indicating that these brain regions are activated by spontaneous mentalizing processes. PMID:28931030

Teaching thoughtful practice: narrative pedagogy in addictions education.

PubMed

Vandermause, Roxanne K; Townsend, Ryan P

2010-07-01

Preparing practitioners for this rapidly changing and demanding health care environment is challenging. A surge in knowledge development and scientific advancement has placed a priority on technical skill and a focus on content driven educational processes that prepare students for evidence-based practice. However, the most difficult health care scenarios require thinking-in-action and thoughtfulness as well as didactic knowledge. It is our contention that interpretive educational methods, like narrative pedagogy, will promote judgment-based practice that includes use of evidence and delivery of thoughtful care. In this article, we describe and interpret a narrative approach to addictions content and teaching thoughtful practice. We present our pedagogical process, including observations and field notes, to show how interpretive pedagogies can be introduced into nursing curricula. By presenting this process, the reader is invited to consider interpretive methods as a way to inspire and habituate thoughtful practice and judgment-based care. Copyright 2009 Elsevier Ltd. All rights reserved.

Postmodern Bioethics through Literature.

ERIC Educational Resources Information Center

Goldstein, Daniel

1994-01-01

Explores a hermeneutical perspective of modern medicine. The author suggests that good medical decision making requires interpretation, and bioethics will be well served by incorporating this interpretive element. (LZ)

Uncertainty Representation and Interpretation in Model-Based Prognostics Algorithms Based on Kalman Filter Estimation

NASA Technical Reports Server (NTRS)

Galvan, Jose Ramon; Saxena, Abhinav; Goebel, Kai Frank

2012-01-01

This article discusses several aspects of uncertainty representation and management for model-based prognostics methodologies based on our experience with Kalman Filters when applied to prognostics for electronics components. In particular, it explores the implications of modeling remaining useful life prediction as a stochastic process, and how it relates to uncertainty representation, management and the role of prognostics in decision-making. A distinction between the interpretations of estimated remaining useful life probability density function is explained and a cautionary argument is provided against mixing interpretations for two while considering prognostics in making critical decisions.

Field and laboratory analyses of water from the Columbia aquifer in Eastern Maryland

USGS Publications Warehouse

Bachman, L.J.

1984-01-01

Field and laboratory analyses of pH, alkalinity, and specific conductance from water samples collected from the Columbia aquifer on the Delmarva Peninsula in eastern Maryland were compared to determine if laboratory analyses could be used for making regional water-quality interpretations. Kruskal-Wallis tests of field and laboratory data indicate that the difference between field and laboratory values is usually not enough to affect the outcome of the statistical tests. Thus, laboratory measurements of these constituents may be adequate for making certain regional water-quality interpretations, although they may result in errors if used for geochemical interpretations.

Despite Best Intentions: A Critical Analysis of Social Justice Leadership and Decision Making

ERIC Educational Resources Information Center

DeMatthews, David E.; Mungal, Angus Shiva; Carrola, Paul A.

2015-01-01

The purpose of this article is to explore the relationship between social justice leadership and organizational decision making in order to make recommendations for how principals can make more socially just decisions in difficult school contexts. This article begins with a discussion of social justice leadership, facets and theories associated…

Interpretation in reproductive genetic counseling: a methodological framework.

PubMed

Tóth, Adél; Szeverényi, Péter

2007-09-01

In case of genetic risk, parents are often faced with reproductive decisions affecting their life essentially, so it is advisable to pursue careful deliberation. For this reason, the genetic counselor is expected to help the counselee make well-informed and well-considered decisions, which requires the understanding of the patient as an individual. To reach emphatic understanding, physicians can use the results of the Gadamerian theory of interpretation that contains the idea -- as it has been summarized by V. Arnason -- that four aspects of openness are necessary to fully understand the other, such as openness to oneself, to the other, to the subject matter and to tradition. In our paper, we are applying the four-openness model of interpretation to genetic consultation, and we argue that during counseling double interpretation takes place: the physician interprets the patient, and the patient interprets the physician. Double interpretation leads to the clarification of those factors which influence the patient's decision-making: the counselor's attitude and prejudices, the counselee's values and needs, the medical, social, and moral implications of the genetic disease, and the social expectations. By adopting the theory of interpretation, counselors can also advance the provision of emotional support patients need in hard situations.

Percutaneous treatment of Lutembacher syndrome in a case with difficult mitral valve crossing.

PubMed

Bhambhani, Anupam; Somanath, H S

2012-03-01

Most cases of combination congenital cardiac anomalies are treated with open-heart surgeries because the coexisting anomalies change the cardiac anatomy in an adverse way, making catheter manipulations complex. Lutembacher syndrome is a combination of acquired mitral stenosis and congenital ostium secundum atrial septal defect. The large defect in the septum makes an Inoue balloon catheter unstable, which provides excessive space for free floatation of the catheter, making its passage into the left ventricle difficult by Inoue technique. We present a case of elective definitive percutaneous treatment of Lutembacher syndrome, discussing the technical difficulties faced in mitral valve crossing and reviewing the possible strategies to improve chances of success.

Charting taxonomic knowledge through ontologies and ranking algorithms

NASA Astrophysics Data System (ADS)

Huber, Robert; Klump, Jens

2009-04-01

Since the inception of geology as a modern science, paleontologists have described a large number of fossil species. This makes fossilized organisms an important tool in the study of stratigraphy and past environments. Since taxonomic classifications of organisms, and thereby their names, change frequently, the correct application of this tool requires taxonomic expertise in finding correct synonyms for a given species name. Much of this taxonomic information has already been published in journals and books where it is compiled in carefully prepared synonymy lists. Because this information is scattered throughout the paleontological literature, it is difficult to find and sometimes not accessible. Also, taxonomic information in the literature is often difficult to interpret for non-taxonomists looking for taxonomic synonymies as part of their research. The highly formalized structure makes Open Nomenclature synonymy lists ideally suited for computer aided identification of taxonomic synonyms. Because a synonymy list is a list of citations related to a taxon name, its bibliographic nature allows the application of bibliometric techniques to calculate the impact of synonymies and taxonomic concepts. TaxonRank is a ranking algorithm based on bibliometric analysis and Internet page ranking algorithms. TaxonRank uses published synonymy list data stored in TaxonConcept, a taxonomic information system. The basic ranking algorithm has been modified to include a measure of confidence on species identification based on the Open Nomenclature notation used in synonymy list, as well as other synonymy specific criteria. The results of our experiments show that the output of the proposed ranking algorithm gives a good estimate of the impact a published taxonomic concept has on the taxonomic opinions in the geological community. Also, our results show that treating taxonomic synonymies as part of on an ontology is a way to record and manage taxonomic knowledge, and thus contribute to the preservation our scientific heritage.

Is advising food allergic patients to avoid food with precautionary allergen labelling out of date?

PubMed

Zurzolo, Giovanni A; de Courten, Maximilian; Koplin, Jennifer; Mathai, Michael L; Allen, Katrina J

2016-06-01

Precautionary allergen labelling (PAL) continues to be used by the food manufacturing industry to alert the food allergic consumer that cross-contact may have occurred during the supply chain for ingredients or the manufacturing process. This review will summarize recent evidence regarding use and interpretation of precautionary labels by industry, healthcare professionals, and food allergic consumers. Consumers find precautionary labels difficult to interpret and often distrust them as disclaimers of product liability. It is unclear from a clinician's perspective how healthcare professionals should advise their patients regarding these statements. Recent studies suggest that consumers do not always read food labels and that these labels are difficult to interpret and are often distrusted by consumers as disclaimers of liability. There is evidence to suggest that this behaviour occurs in all countries assessed that use PAL. The healthcare professional remains confused about the interpretation and value of the current PAL system as it is unclear whether foods that contain no advisory labels are safe to consume. There is a need for improvement in the value and use of precautionary labelling for allergen risk assessment for allergic consumers. New studies have shown the confusion that currently exists in regard to PAL for the healthcare professional and the consumer alike. The studies have also highlighted certain gaps in the literature that, once addressed, will improve the uniformity of PAL and provide the healthcare professional with appropriate advice which they can in turn relay to the allergic consumer. Because of the global supply of food products there is a need for an international approach in improving PAL.

Laboratory testing in hyperthyroidism.

PubMed

Grebe, Stefan K G; Kahaly, George J

2012-09-01

The clinical diagnosis of hypo- or hyperthyroidism is difficult (full text available online: http://education.amjmed.com/pp1/272). Clinical symptoms and signs are often non-specific, and there is incomplete correlation between structural and functional thyroid gland changes. Laboratory testing is therefore indispensible in establishing the diagnosis of thyrotoxicosis. Similar considerations apply to treatment monitoring. Laboratory testing also plays a crucial role in establishing the most likely cause for a patient's hyperthyroidism. Finally, during pregnancy, when isotopic scanning is relatively contraindicated and ultrasound is more difficult to interpret, laboratory testing becomes even more important. Copyright © 2012. Published by Elsevier Inc.

Improved scintimammography using a high-resolution camera mounted on an upright mammography gantry

NASA Astrophysics Data System (ADS)

Itti, Emmanuel; Patt, Bradley E.; Diggles, Linda E.; MacDonald, Lawrence; Iwanczyk, Jan S.; Mishkin, Fred S.; Khalkhali, Iraj

2003-01-01

99mTc-sestamibi scintimammography (SMM) is a useful adjunct to conventional X-ray mammography (XMM) for the assessment of breast cancer. An increasing number of studies has emphasized fair sensitivity values for the detection of tumors >1 cm, compared to XMM, particularly in situations where high glandular breast densities make mammographic interpretation difficult. In addition, SMM has demonstrated high specificity for cancer, compared to various functional and anatomic imaging modalities. However, large field-of-view (FOV) gamma cameras are difficult to position close to the breasts, which decreases spatial resolution and subsequently, the sensitivity of detection for tumors <1 cm. New dedicated detectors featuring small FOV and increased spatial resolution have recently been developed. In this setting, improvement in tumor detection sensitivity, particularly with regard to small cancers is expected. At Division of Nuclear Medicine, Harbor-UCLA Medical Center, we have performed over 2000 SMM within the last 9 years. We have recently used a dedicated breast camera (LumaGEM™) featuring a 12.8×12.8 cm 2 FOV and an array of 2×2×6 mm 3 discrete crystals coupled to a photon-sensitive photomultiplier tube readout. This camera is mounted on a mammography gantry allowing upright imaging, medial positioning and use of breast compression. Preliminary data indicates significant enhancement of spatial resolution by comparison with standard imaging in the first 10 patients. Larger series will be needed to conclude on sensitivity/specificity issues.

Crystal pathologies in macromolecular crystallography.

PubMed

Dauter, Zbigniew; Jaskólski, Mariusz

Macromolecules, such as proteins or nucleic acids, form crystals with a large volume fraction of water, ~50% on average. Apart from typical physical defects and rather trivial poor quality problems, macromolecular crystals, as essentially any crystals, can also suffer from several kinds of pathologies, in which everything seems to be perfect, except that from the structural point of view the interpretation may be very difficult, sometimes even impossible. A frequent nuisance is pseudosymmetry, or non-crystallographic symmetry (NCS), which is particularly nasty when it has translational character. Lattice-translocation defects, also called order-disorder twinning (OD-twinning), occur when molecules are packed regularly in layers but the layers are stacked (without rotation) in two (or more) discrete modes, with a unique translocation vector. Crystal twinning arises when twin domains have different orientations, incompatible with the symmetry of the crystal structure. There are also crystals in which the periodic (lattice) order is broken or absent altogether. When the strict short-range translational order from one unit cell to the next is lost but the long-range order is restored by a periodic modulation, we have a modulated crystal structure. In quasicrystals (not observed for macromolecules yet), the periodic order (in 3D space) is lost completely and the diffraction pattern (which is still discrete) cannot be even indexed using three hkl indices. In addition, there are other physical defects and phenomena (such as high mosaicity, diffraction anisotropy, diffuse scattering, etc.) which make diffraction data processing and structure solution difficult or even impossible.

Substance use disorder and compulsory commitment to care: a care-ethical decision-making framework.

PubMed

Nicolini, Marie; Vandenberghe, Joris; Gastmans, Chris

2017-11-29

In the era of deinstitutionalisation of psychiatric patients, steady or even increasing rates of compulsory commitment to care (CCC) are an intriguing phenomenon to analyse. From a clinical, legal and ethical perspective, CCC continues to be a controversial practice in psychiatry, and perhaps even more so when applied to patients with severe substance use disorder (SUD). Several reasons make it controversial. The lack of consensus about the benefits of CCC and professional disagreement about what mental illness and autonomy mean in the case of SUD make it difficult to apply ethically sound clinical decision-making in CCC. Also, the medico-legal framework underlying CCC use sometimes appears to foster the use of reductionist clinical evaluation. Layered on top of these issues is how stakeholders view coercion. There is a discrepancy between clinicians' and patients' perception of coercion, which leads to clinician-patient differences on whether CCC is necessary. Moreover, the way in which the evaluation is typically carried out influences patients' perception of coercion and subsequently their motivation for participating fully in treatment. In this article, we explore the value of care ethics, often applied to care practices such as nursing, when applied to more procedural medical practices, such as decision-making regarding CCC. The care-ethical approach views decision-making as part of a dynamic care process, within which the lived experience, interpretative dialogue and promotion of dignity are core features. Embracing this new framework means a paradigm shift in when the therapeutic relationship begins, namely, investing in it occurs while conducting an evaluation for a possible CCC procedure. Unlike in current typical evaluations, early cultivation of the therapeutic relationship enables the patient to participate in the definition of his needs, reduces perceived coercion and negative emotions and enhances treatment motivation. Finally, implications of this novel approach for clinical practice are formulated and discussed. © 2017 Nordic College of Caring Science.

Use of ultrasonography to make management decisions

USDA-ARS?s Scientific Manuscript database

Transrectal ultrasonography has been available for making management decisions since the mid 1980’s. This technology allows for the real-time visualization of internal structures (i.e. ovary and fetus) that are otherwise difficult to evaluate. The use of this technology in making reproductive manag...

Making Difficult Things Easy and Easy Things Difficult.

ERIC Educational Resources Information Center

Campbell, J. Arthur; Bent, Henry A.

1982-01-01

Suggestions are offered to illustrate concepts and processes by using simple materials such as paper, paper clip, rubber band (bonding, entropy, endothermic processes). Also suggests using basic terminology: elementary ratios, percent, reaction chemistry for entropy function; equilibrium constants for Gibbs energies; and chemical mechanics for…

A Critique and Defense of Gamification

ERIC Educational Resources Information Center

Hung, Aaron Chia Yuan

2017-01-01

Gamification has received increased attention in education in recent years, and is seen as a way to improve student engagement, motivation, attendance, and academic performance. While empirical studies on gamification in higher education are showing modest gains in some areas, this data can be difficult to interpret because of the many ways that…

Interpreting the Value of Ecosystem Services in a Great Lakes Estuary from the Behavior of Individuals and Communities

EPA Science Inventory

Fundamentally, economists study human behavior. Financial and political investments are justified in terms of the real, perceived, or potential value of benefits. Unlike economic systems, investments in and benefits from ecosystems are difficult to monetize. We are applying alter...

When 95% Accurate Isn't: Exploring Bayes's Theorem

ERIC Educational Resources Information Center

CadwalladerOlsker, Todd D.

2011-01-01

Bayes's theorem is notorious for being a difficult topic to learn and to teach. Problems involving Bayes's theorem (either implicitly or explicitly) generally involve calculations based on two or more given probabilities and their complements. Further, a correct solution depends on students' ability to interpret the problem correctly. Most people…

Deficit irrigation: Arriving at the crop water stress index via gas exchange measurements

USDA-ARS?s Scientific Manuscript database

Plant gas exchange provides a highly sensitive measure of the degree of drought stress. Canopy temperature (Tc) provides a much easier to acquire indication of crop water deficit that has been used in irrigation scheduling systems, but interpretation of this measurement has proven difficult. Our goa...

Immunogenomics: a foundation for intelligent immune design.

PubMed

Holt, Robert A

2015-11-19

The complexity of the immune system is now being interrogated using methodologies that generate extensive multi-dimensional data. Effective collection, integration and interpretation of these data remain difficult, but overcoming these important challenges will provide new insights into immune function and opportunities for the rational design of new immune interventions.

Gentle Interventions

ERIC Educational Resources Information Center

Halas, Joannie; van Ingen, Cathy

2009-01-01

By examining specific examples of how teachers at an adolescent treatment centre interpret the day to day challenges that shape the lives of their students, insights can be gained about how schools can effectively re-connect even the most difficult students to a school environment. This article describes a story about an adolescent treatment…

Thermogravimetric and differential thermal analysis of potassium bicarbonate contaminated cellulose

Treesearch

A. Broido

1966-01-01

When samples undergo a complicated set of simultaneous and sequential reactions, as cellulose does on heating, results of thermogravimetric and differential thermal analyses are difficult to interpret. Nevertheless, careful comparison of pure and contaminated samples, pyrolyzed under identical conditions, can yield useful information. In these experiments TGA and DTA...

Ultimate Realities: Deterministic and Evolutionary

ERIC Educational Resources Information Center

Moxley, Roy A.

2007-01-01

References to ultimate reality commonly turn up in the behavioral literature as references to determinism. However, this determinism is often difficult to interpret. There are different kinds of determinisms as well as different kinds of ultimate realities for a behaviorist to consider. To clarify some of the issues involved, the views of ultimate…

Exploration of Heterogeneity in Distributed Research Network Drug Safety Analyses

ERIC Educational Resources Information Center

Hansen, Richard A.; Zeng, Peng; Ryan, Patrick; Gao, Juan; Sonawane, Kalyani; Teeter, Benjamin; Westrich, Kimberly; Dubois, Robert W.

2014-01-01

Distributed data networks representing large diverse populations are an expanding focus of drug safety research. However, interpreting results is difficult when treatment effect estimates vary across datasets (i.e., heterogeneity). In a previous study, risk estimates were generated for selected drugs and potential adverse outcomes. Analyses were…

DETECTABILITY AND UNCERTAINTIES IN THE ESTIMATION OF THE IMPACTS OF LAND DISTURBANCES ON CATCHMENT RUNOFF

EPA Science Inventory

Interpretation of the impacts of land disturbances on hydrology is confounded by climate variations. Clear definition of the anthropogenic impacts has been difficult, especially in cases where a clearly defined base line or reference point is absent. This study investigates the d...

Speed Pairs, a Spoken Exercise

ERIC Educational Resources Information Center

Kishi, Adrienne

2017-01-01

While written exercises may serve students adequately on tests, the structures they emphasize can remain elusive or difficult for students to master in conversation. Students tend to interpret their difficulty in applying what they have learned as a lack of language ability, and they can quickly lose confidence when speaking. Producing a target…

Understanding Deaf Readers: An Interpretative Phenomenological Analysis

ERIC Educational Resources Information Center

Kelstone, Aaron Weir

2013-01-01

The development of reading skills, beyond a functional level, is difficult for most deaf readers. Standardized testing demonstrates a median 4th grade reading level that remains consistent even after national norming of the Stanford Achievement test on the population of deaf school children. Deaf education continues to generate various educational…

High-mass stars in Milky Way clusters

NASA Astrophysics Data System (ADS)

Negueruela, Ignacio

2017-11-01

Young open clusters are our laboratories for studying high-mass star formation and evolution. Unfortunately, the information that they provide is difficult to interpret, and sometimes contradictory. In this contribution, I present a few examples of the uncertainties that we face when confronting observations with theoretical models and our own assumptions.

Artificial neural networks in mammography interpretation and diagnostic decision making.

PubMed

Ayer, Turgay; Chen, Qiushi; Burnside, Elizabeth S

2013-01-01

Screening mammography is the most effective means for early detection of breast cancer. Although general rules for discriminating malignant and benign lesions exist, radiologists are unable to perfectly detect and classify all lesions as malignant and benign, for many reasons which include, but are not limited to, overlap of features that distinguish malignancy, difficulty in estimating disease risk, and variability in recommended management. When predictive variables are numerous and interact, ad hoc decision making strategies based on experience and memory may lead to systematic errors and variability in practice. The integration of computer models to help radiologists increase the accuracy of mammography examinations in diagnostic decision making has gained increasing attention in the last two decades. In this study, we provide an overview of one of the most commonly used models, artificial neural networks (ANNs), in mammography interpretation and diagnostic decision making and discuss important features in mammography interpretation. We conclude by discussing several common limitations of existing research on ANN-based detection and diagnostic models and provide possible future research directions.

Validation of educational assessments: a primer for simulation and beyond.

PubMed

Cook, David A; Hatala, Rose

2016-01-01

Simulation plays a vital role in health professions assessment. This review provides a primer on assessment validation for educators and education researchers. We focus on simulation-based assessment of health professionals, but the principles apply broadly to other assessment approaches and topics. Validation refers to the process of collecting validity evidence to evaluate the appropriateness of the interpretations, uses, and decisions based on assessment results. Contemporary frameworks view validity as a hypothesis, and validity evidence is collected to support or refute the validity hypothesis (i.e., that the proposed interpretations and decisions are defensible). In validation, the educator or researcher defines the proposed interpretations and decisions, identifies and prioritizes the most questionable assumptions in making these interpretations and decisions (the "interpretation-use argument"), empirically tests those assumptions using existing or newly-collected evidence, and then summarizes the evidence as a coherent "validity argument." A framework proposed by Messick identifies potential evidence sources: content, response process, internal structure, relationships with other variables, and consequences. Another framework proposed by Kane identifies key inferences in generating useful interpretations: scoring, generalization, extrapolation, and implications/decision. We propose an eight-step approach to validation that applies to either framework: Define the construct and proposed interpretation, make explicit the intended decision(s), define the interpretation-use argument and prioritize needed validity evidence, identify candidate instruments and/or create/adapt a new instrument, appraise existing evidence and collect new evidence as needed, keep track of practical issues, formulate the validity argument, and make a judgment: does the evidence support the intended use? Rigorous validation first prioritizes and then empirically evaluates key assumptions in the interpretation and use of assessment scores. Validation science would be improved by more explicit articulation and prioritization of the interpretation-use argument, greater use of formal validation frameworks, and more evidence informing the consequences and implications of assessment.

Intercultural Interpretations: Making Public Relations Education Culturally Relevant

ERIC Educational Resources Information Center

Chia, Joy

2009-01-01

Public relations educators delivering courses to international students find that each cohort of students interprets and understands public relations theory and its application to practice according to their respective cultures. The premise of this paper is to reflect on some of the interpretations and expectations of public relations students…

Theoretical, observational, and isotopic estimates of the lifetime of the solar nebula

NASA Technical Reports Server (NTRS)

Podosek, Frank A.; Cassen, Patrick

1994-01-01

There are a variety of isotopic data for meteorites which suggest that the protostellar nebula existed and was involved in making planetary materials for some 10(exp 7) yr or more. Many cosmochemists, however, advocate alternative interpretations of such data in order to comply with a perceived constraint, from theoretical considerations, that the nebula existed only for a much shorter time, usually stated as less than or equal to 10(exp 6) yr. In this paper, we review evidence relevant to solar nebula duration which is available through three different disciplines: theoretical modeling of star formation, isotopic data from meteorites, and astronomical observations of T Tauri stars. Theoretical models based on observations of present star-forming regions indicate that stars like the Sun form by dynamical gravitational collapse of dense cores of cold molcular clouds in the interstellar clouds in the interstellar medium. The collapse to a star and disk occurs rapidly, on a time scale of the order 10(exp 5) yr. Disks evolve by dissipating energy while redistributing angular momentum, but it is difficult to predict the rate of evolution, particularly for low mass (compared to the star) disks which nonetheless still contain enough material to account for the observed planetary system. There is no compelling evidence, from available theories of disk structure and evolution, that the solar nebula must have evolved rapidly and could not have persisted for more than 1 Ma. In considering chronoloically relevant isotopic data for meteorites, we focus on three methodologies: absolute ages by U-Pb/Pb-Pb, and relative ages by short-lived radionuclides (especially Al-26) and by evolution of Sr-87/Sr-86. Two kinds of meteoritic materials-refractory inclusions such as CAIs and differential meteorites (eucrites and augrites) -- appear to have experienced potentially dateable nebular events. In both cases, the most straightforward interpretations of the available data indicate nebular events spanning several Ma. We also consider alternative interpretations, particularly the hypothesis of radically heterogeneous distribution of Al-26, which would avoid these chronological interpretations. The principal impetus for such alternative interpretations seems to be precisely the obviation of the chronological interpretation (i.e., the presumption rather than the inference of a short (less than or equal to 1 Ma) lifetime of the nebula). Astronomical observations of T Tauri stars indicate that the presence of dusty disks is a common if not universal feature, that the disks are massive enough to accomodate a planetary system such as ours, and that at least some persist for 110(exp 7) yr or more. The results are consistent with the time scales inferred from the meteoritic isotopic data. They cannot be considered conclusive with regard to solar nebula time scales, however, in part because it is difficult to relate disk observations to processes that affect meteorites, and in part because the ages assigned for these stars could be wrong by a factor of several in either direction. We conclude that the balance of available evidence favors the view that the nebula existed and was active for at least several Ma. However, because the evidence is not definitive, it is important that the issue be perceived to be an open question, whose answer should be sought rather than presumed.

Theoretical, observational, and isotopic estimates of the lifetime of the solar nebula

NASA Technical Reports Server (NTRS)

Podosek, Frank A.; Cassen, Patrick

1994-01-01

There are a variety of isotopic data for meteorites which suggest that the protostellar nebula existed and was involved in making planetary materials for some 10(exp 7) yr or more. Many cosmochemists, however, advocate alternative interpretations of such data in order to comply with a perceived constraint, from theoretical considerations, that the nebula existed only for a much shorter time, usually stated as less than or = 10(exp 6) yr. In this paper, we review evidence relevant to solar nebula duration which is available through three different disciplines: theoretical modelling of star formation, isotopic data from meteorites, and astronomical observations of T Tauri stars. Theoretical models based on observations of present star-forming regions indicate that stars like the Sun form by dynamical gravitational collapse of dense cores of cold molecular clouds in the interstellar medium. The collapse to a star and disk occurs rapidly on a time scale of the order 10(exp 5) yr. Disks evolve by dissipating energy while redistributing angular momentum, but it is difficult to predict the rate of evolution, particularly for low mass (compared to the star) disks which nonetheless still contain enough material to account for the observed planetary system. There is no compelling evidence, from available theories of disk structure and evolution, that the solar nebula must have evolved rapidly and could not have persisted for more than 1 Ma. In considering chronologically relevant isotopic data for meteorites, we focus on three methodologies: absolute ages by U-Pb/Pb-Pb, and relative ages by short-lived radionuclides (especially Al-26) and by evolution of Sr-87/Sr-86. Two kinds of meteoritic materials-refractory inclusions such as CAIs and differentiated meteorites (eucrites and angrites) - appear to have experience potentially dateable nebular events. In both case, the most straightforward interpretations of the available data indicate nebular events spanning several Ma. We also consider alternative interpretations, particularly the hypothesis of radically heterogeneous distribution of Al-26, which would avoid these chronological interpretations. The principal impetus for such alternative interpretations seems to be precisely the obviation of the chronological interpretation (i.e., the presumption rather than the inference of a short (less than or = Ma) lifetime of the nebula). Astronomical observations of T Tauri stars indicate that the presence of dusty disks is a common if not universal feature, that the disks are massive enough to accomodate a planetary system such as ours, and that at least some persist for 10(exp 7) yr or more. The results are consistent with the time scales inferred from the meteorite isotopic data. They cannot be considered conclusive with regard to solar nebula time scales, however,in part because it is difficult to relate disk observations to processes that affect meteorites, and in part because the ages assigned for these stars could be wrong by a factor of several in either direction. We conclude that the balance of available evidence favors the view that the nebula existed and was active for at least several Ma. However, because the evidence is not definitive, it is important that the issue be perceived to be an open question, whose answer should be sought rather than presumed.

Use of ultrasonography to make reproductive management decisions

USDA-ARS?s Scientific Manuscript database

Transrectal ultrasonography has been available for making management decisions since the mid 1980’s. This technology allows for the real-time visualization of internal structures (i.e. ovary and fetus) that are otherwise difficult to evaluate. The use of this technology in making reproductive manag...

Differences in spirometry interpretation algorithms: influence on decision making among primary-care physicians

PubMed Central

He, Xiao-Ou; D’Urzo, Anthony; Jugovic, Pieter; Jhirad, Reuven; Sehgal, Prateek; Lilly, Evan

2015-01-01

Background: Spirometry is recommended for the diagnosis of asthma and chronic obstructive pulmonary disease (COPD) in international guidelines and may be useful for distinguishing asthma from COPD. Numerous spirometry interpretation algorithms (SIAs) are described in the literature, but no studies highlight how different SIAs may influence the interpretation of the same spirometric data. Aims: We examined how two different SIAs may influence decision making among primary-care physicians. Methods: Data for this initiative were gathered from 113 primary-care physicians attending accredited workshops in Canada between 2011 and 2013. Physicians were asked to interpret nine spirograms presented twice in random sequence using two different SIAs and touch pad technology for anonymous data recording. Results: We observed differences in the interpretation of spirograms using two different SIAs. When the pre-bronchodilator FEV1/FVC (forced expiratory volume in one second/forced vital capacity) ratio was >0.70, algorithm 1 led to a ‘normal’ interpretation (78% of physicians), whereas algorithm 2 prompted a bronchodilator challenge revealing changes in FEV1 that were consistent with asthma, an interpretation selected by 94% of physicians. When the FEV1/FVC ratio was <0.70 after bronchodilator challenge but FEV1 increased >12% and 200 ml, 76% suspected asthma and 10% suspected COPD using algorithm 1, whereas 74% suspected asthma versus COPD using algorithm 2 across five separate cases. The absence of a post-bronchodilator FEV1/FVC decision node in algorithm 1 did not permit consideration of possible COPD. Conclusions: This study suggests that differences in SIAs may influence decision making and lead clinicians to interpret the same spirometry data differently. PMID:25763716

Strengthening forensic DNA decision making through a better understanding of the influence of cognitive bias.

PubMed

Jeanguenat, Amy M; Budowle, Bruce; Dror, Itiel E

2017-11-01

Cognitive bias may influence process flows and decision making steps in forensic DNA analyses and interpretation. Currently, seven sources of bias have been identified that may affect forensic decision making with roots in human nature; environment, culture, and experience; and case specific information. Most of the literature and research on cognitive bias in forensic science has focused on patterned evidence; however, forensic DNA testing is not immune to bias, especially when subjective interpretation is involved. DNA testing can be strengthened by recognizing the existence of bias, evaluating where it influences decision making, and, when applicable, implementing practices to reduce or control its effects. Elements that may improve forensic decision making regarding bias include cognitively informed education and training, quality assurance procedures, review processes, analysis and interpretation, and context management of irrelevant information. Although bias exists, reliable results often can be (and have been) produced. However, at times bias can (and has) impacted the interpretation of DNA results negatively. Therefore, being aware of the dangers of bias and implementing measures to control its potential impact should be considered. Measures and procedures that handicap the workings of the crime laboratory or add little value to improving the operation are not advocated, but simple yet effective measures are suggested. This article is meant to raise awareness of cognitive bias contamination in forensic DNA testing and to give laboratories possible pathways to make sound decisions to address its influences. Copyright © 2017 The Chartered Society of Forensic Sciences. Published by Elsevier B.V. All rights reserved.

Diffusion Modelling Reveals the Decision Making Processes Underlying Negative Judgement Bias in Rats

PubMed Central

Hales, Claire A.; Robinson, Emma S. J.; Houghton, Conor J.

2016-01-01

Human decision making is modified by emotional state. Rodents exhibit similar biases during interpretation of ambiguous cues that can be altered by affective state manipulations. In this study, the impact of negative affective state on judgement bias in rats was measured using an ambiguous-cue interpretation task. Acute treatment with an anxiogenic drug (FG7142), and chronic restraint stress and social isolation both induced a bias towards more negative interpretation of the ambiguous cue. The diffusion model was fit to behavioural data to allow further analysis of the underlying decision making processes. To uncover the way in which parameters vary together in relation to affective state manipulations, independent component analysis was conducted on rate of information accumulation and distances to decision threshold parameters for control data. Results from this analysis were applied to parameters from negative affective state manipulations. These projected components were compared to control components to reveal the changes in decision making processes that are due to affective state manipulations. Negative affective bias in rodents induced by either FG7142 or chronic stress is due to a combination of more negative interpretation of the ambiguous cue, reduced anticipation of the high reward and increased anticipation of the low reward. PMID:27023442

From Learning to Decision-Making: A Cross-Sectional Survey of a Clinical Pharmacist-Steered Journal Club

PubMed Central

Ismail, Sherine; Al Khansa, Sara; Aseeri, Mohammed; Alhamdan, Hani; Quadri, K. H. Mujtaba

2017-01-01

Journal clubs have been traditionally incorporated into academic training programs to enhance competency in the interpretation of literature. We designed a structured journal club (JC) to improve skills in the interpretation of literature; however, we were not aware of how learners (interns, residents, clinical pharmacists, etc.) would perceive it. We aimed to assess the perception of learners at different levels of pharmacy training. A cross-sectional design was used. A self-administered online survey was emailed to JC attendees from 2010–2014 at King Abdulaziz Medical City, Jeddah, Saudi Arabia. The survey questions included: introduction sessions, topic selection, JC layout, interaction with the moderator, and decision-making skills by clinical pharmacists. The response rate was 58/89 (65%); 52/54 (96%) respondents believed that JC adds to their knowledge in interpreting literature. Topic selection met the core curriculum requirements for credentials exams for 16/36 (44.4%), while 16/22 (73%) presenters had good to excellent interaction with the moderator. JC facilitated decision-making for 10/12 (83%) of clinical pharmacists. The results suggest that clinical pharmacist-steered JC may serve as an effective tool to empower learners at different levels of pharmacy practice, with evidence-based principles for interpretation of literature and guide informed decision-making. PMID:28970415

Studying extragalactic background fluctuations with the Cosmic Infrared Background ExpeRiment 2 (CIBER-2)

NASA Astrophysics Data System (ADS)

Lanz, Alicia; Arai, Toshiaki; Battle, John; Bock, James; Cooray, Asantha; Hristov, Viktor; Korngut, Phillip; Lee, Dae Hee; Mason, Peter; Matsumoto, Toshio; Matsuura, Shuji; Morford, Tracy; Onishi, Yosuke; Shirahata, Mai; Tsumura, Kohji; Wada, Takehiko; Zemcov, Michael

2014-08-01

Fluctuations in the extragalactic background light trace emission from the history of galaxy formation, including the emission from the earliest sources from the epoch of reionization. A number of recent near-infrared measure- ments show excess spatial power at large angular scales inconsistent with models of z < 5 emission from galaxies. These measurements have been interpreted as arising from either redshifted stellar and quasar emission from the epoch of reionization, or the combined intra-halo light from stars thrown out of galaxies during merging activity at lower redshifts. Though astrophysically distinct, both interpretations arise from faint, low surface brightness source populations that are difficult to detect except by statistical approaches using careful observations with suitable instruments. The key to determining the source of these background anisotropies will be wide-field imaging measurements spanning multiple bands from the optical to the near-infrared. The Cosmic Infrared Background ExpeRiment 2 (CIBER-2) will measure spatial anisotropies in the extra- galactic infrared background caused by cosmological structure using six broad spectral bands. The experiment uses three 2048 x 2048 Hawaii-2RG near-infrared arrays in three cameras coupled to a single 28.5 cm telescope housed in a reusable sounding rocket-borne payload. A small portion of each array will also be combined with a linear-variable filter to make absolute measurements of the spectrum of the extragalactic background with high spatial resolution for deep subtraction of Galactic starlight. The large field of view and multiple spectral bands make CIBER-2 unique in its sensitivity to fluctuations predicted by models of lower limits on the luminosity of the first stars and galaxies and in its ability to distinguish between primordial and foreground anisotropies. In this paper the scientific motivation for CIBER-2 and details of its first flight instrumentation will be discussed, including detailed designs of the mechanical, cryogenic, and electrical systems. Plans for the future will also be presented.

The JCMT Transient Survey: Detection of Submillimeter Variability in a Class I Protostar EC 53 in Serpens Main

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yoo, Hyunju; Cho, Jungyeon; Lee, Jeong-Eun

During the protostellar phase of stellar evolution, accretion onto the star is expected to be variable, but this suspected variability has been difficult to detect because protostars are deeply embedded. In this paper, we describe a submillimeter luminosity burst of the Class I protostar EC 53 in Serpens Main, the first variable found during our dedicated JCMT/SCUBA-2 monitoring program of eight nearby star-forming regions. EC 53 remained quiescent for the first six months of our survey, from 2016 February to August. The submillimeter emission began to brighten in 2016 September, reached a peak brightness of 1.5 times the faint state,more » and has been decaying slowly since 2017 February. The change in submillimeter brightness is interpreted as dust heating in the envelope, generated by a luminosity increase of the protostar of a factor of ≥4. The 850 μ m light curve resembles the historical K -band light curve, which varies by a factor of ∼6 with a 543 period and is interpreted as accretion variability excited by interactions between the accretion disk and a close binary system. The predictable detections of accretion variability observed at both near-infrared and submillimeter wavelengths make the system a unique test-bed, enabling us to capture the moment of the accretion burst and to study the consequences of the outburst on the protostellar disk and envelope.« less

Correction of motion artifacts in OCT-AFI data collected in airways (Conference Presentation)

NASA Astrophysics Data System (ADS)

Abouei, Elham; Lane, Pierre M.; Pahlevaninezhad, Hamid; Lee, Anthony; Lam, Stephen; MacAulay, Calum E.

2016-03-01

Abstract: Optical coherence tomography (OCT) provides in vivo imaging with near-histologic resolution of tissue morphology. OCT has been successfully employed in clinical practice in non-pulmonary fields of medicine such as ophthalmology and cardiology. Studies suggest that OCT has the potential to be a powerful tool for the detection and localization of malignant and non-malignant pulmonary diseases. The combination of OCT with autofluorescence imaging (AFI) provides valuable information about the structural and metabolic state of tissues. Successful application of OCT or OCT-AFI to the field of pulmonary medicine requires overcoming several challenges. This work address those associated with motion: cardiac cycle, breathing and non-uniform rotation distortion (NURD) artifacts. Mechanically rotated endoscopic probes often suffer from image degradation due to NURD. In addition cardiac and breathing motion artifacts may be present in-vivo that are not seen ex-vivo. These motion artifacts can be problematic in OCT-AFI systems with slower acquisition rates and have been observed to generate identifiable prominent artifacts which make confident interpretation of observed structures (blood vessels, etc) difficult. Understanding and correcting motion artifact could improve the image quality and interpretation. In this work, the motion artifacts in pulmonary OCT-AFI data sets are estimated in both AFI and OCT images using a locally adaptive registration algorithm that can be used to correct/reduce such artifacts. Performance of the algorithm is evaluated on images of a NURD phantom and on in-vivo OCT-AFI datasets of peripheral lung airways.

Phylogenetically resolving epidemiologic linkage

PubMed Central

Romero-Severson, Ethan O.; Bulla, Ingo; Leitner, Thomas

2016-01-01

Although the use of phylogenetic trees in epidemiological investigations has become commonplace, their epidemiological interpretation has not been systematically evaluated. Here, we use an HIV-1 within-host coalescent model to probabilistically evaluate transmission histories of two epidemiologically linked hosts. Previous critique of phylogenetic reconstruction has claimed that direction of transmission is difficult to infer, and that the existence of unsampled intermediary links or common sources can never be excluded. The phylogenetic relationship between the HIV populations of epidemiologically linked hosts can be classified into six types of trees, based on cladistic relationships and whether the reconstruction is consistent with the true transmission history or not. We show that the direction of transmission and whether unsampled intermediary links or common sources existed make very different predictions about expected phylogenetic relationships: (i) Direction of transmission can often be established when paraphyly exists, (ii) intermediary links can be excluded when multiple lineages were transmitted, and (iii) when the sampled individuals’ HIV populations both are monophyletic a common source was likely the origin. Inconsistent results, suggesting the wrong transmission direction, were generally rare. In addition, the expected tree topology also depends on the number of transmitted lineages, the sample size, the time of the sample relative to transmission, and how fast the diversity increases after infection. Typically, 20 or more sequences per subject give robust results. We confirm our theoretical evaluations with analyses of real transmission histories and discuss how our findings should aid in interpreting phylogenetic results. PMID:26903617

Phylogenetically resolving epidemiologic linkage

DOE PAGES

Romero-Severson, Ethan O.; Bulla, Ingo; Leitner, Thomas

2016-02-22

The use of phylogenetic trees in epidemiological investigations has become commonplace, but their epidemiological interpretation has not been systematically evaluated. Here, we use an HIV-1 within-host coalescent model to probabilistically evaluate transmission histories of two epidemiologically linked hosts. Previous critique of phylogenetic reconstruction has claimed that direction of transmission is difficult to infer, and that the existence of unsampled intermediary links or common sources can never be excluded. The phylogenetic relationship between the HIV populations of epidemiologically linked hosts can be classified into six types of trees, based on cladistic relationships and whether the reconstruction is consistent with the truemore » transmission history or not. We show that the direction of transmission and whether unsampled intermediary links or common sources existed make very different predictions about expected phylogenetic relationships: (i) Direction of transmission can often be established when paraphyly exists, (ii) intermediary links can be excluded when multiple lineages were transmitted, and (iii) when the sampled individuals’ HIV populations both are monophyletic a common source was likely the origin. Inconsistent results, suggesting the wrong transmission direction, were generally rare. In addition, the expected tree topology also depends on the number of transmitted lineages, the sample size, the time of the sample relative to transmission, and how fast the diversity increases after infection. Typically, 20 or more sequences per subject give robust results. Moreover, we confirm our theoretical evaluations with analyses of real transmission histories and discuss how our findings should aid in interpreting phylogenetic results.« less

[Nutrigenetics and nutrigenomics - application of „omics” technologies in optimization of human nutrition].

PubMed

Panczyk, Mariusz

2013-01-01

Nowadays nutrigenetics and nutrigenomics are perceived as one of the most important research areas ensuring better understanding of an impact of nutrition on human health. Since such researches are interdisciplinary in type, there is a problem with their widespread acceptance and practical clinical application of obtained results. Understanding the new ideas and hypotheses published in researches on nutrigenetics/nutrigenomics requires some knowledge of genetics, biochemistry, molecular biology, and capabilities and limitations that are associated with the use of statistical and bioinformatic analysis, and above all „omics” research technologies (genomics, transcriptomics, proteomics, metabolomics). Highly efficient genome and proteome analysis techniques allow to obtain data necessary for profiling of an individual patient. The main problem is still our insufficient knowledge of cell physiology and biochemistry. The vast amount of information is obtained with the use of „omics” technologies what makes it difficult to interpret and infer. An unquestionable advantage of this type of research is the possibility to utilize system analysis (system biology) which is important in the context of a holistic interpretation of biological phenomena. This review is an attempt to present the main hypotheses and objectives which are carried out by researchers in nutrigenetics/nutrigenomics. This article describes the most important directions of research and anticipated results that are related to the practical use of nutritional genomics as well as the critical assessment of the possible impact of future developments on public health.

Prescribing without evidence – pregnancy

PubMed Central

Thomas, Simon H L; Yates, Laura M

2012-01-01

Prescribing of medicines during pregnancy is common, and for some groups of women is essential for maintaining maternal and therefore fetal health. Pregnant women and prescribers are rightly concerned, however, about the potential adverse fetal effects of medicines. These may include fetal death or stillbirth, congenital malformations, developmental impairment, neonatal effects or late carcinogenesis. It is therefore essential that the risks and benefits for mother and fetus are considered carefully before prescribing in pregnancy. This is often challenging because of the paucity of information available. To complicate the issue further, drug pharmacokinetics are commonly altered in pregnancy, potentially affecting optimal dosing as well as interpretation of plasma concentration measurements, with specific information on individual drugs seldom available. Most drugs cross the placenta, especially lipophilic drugs and those with low plasma protein binding. Active membrane transporters also have an important role in enhancing or preventing drug transfer, although this is not yet clearly understood. Animal studies have limited applicability to humans because of species-specific effects, and clinical trials in pregnancy are only undertaken in special circumstances. Prescribers therefore need to rely on observational studies of fetal outcomes following drug exposure in human pregnancy. These often involve limited numbers, and data are also subject to confounding and bias, making interpretation difficult. It therefore remains essential that appropriate mechanisms for systematic data collection, including congenital malformation registries, teratology information services, pregnancy registers and linked population registries, are maintained and enhanced to increase the amount and quality of information available. PMID:22607226

DOE Office of Scientific and Technical Information (OSTI.GOV)

Romero-Severson, Ethan O.; Bulla, Ingo; Leitner, Thomas

The use of phylogenetic trees in epidemiological investigations has become commonplace, but their epidemiological interpretation has not been systematically evaluated. Here, we use an HIV-1 within-host coalescent model to probabilistically evaluate transmission histories of two epidemiologically linked hosts. Previous critique of phylogenetic reconstruction has claimed that direction of transmission is difficult to infer, and that the existence of unsampled intermediary links or common sources can never be excluded. The phylogenetic relationship between the HIV populations of epidemiologically linked hosts can be classified into six types of trees, based on cladistic relationships and whether the reconstruction is consistent with the truemore » transmission history or not. We show that the direction of transmission and whether unsampled intermediary links or common sources existed make very different predictions about expected phylogenetic relationships: (i) Direction of transmission can often be established when paraphyly exists, (ii) intermediary links can be excluded when multiple lineages were transmitted, and (iii) when the sampled individuals’ HIV populations both are monophyletic a common source was likely the origin. Inconsistent results, suggesting the wrong transmission direction, were generally rare. In addition, the expected tree topology also depends on the number of transmitted lineages, the sample size, the time of the sample relative to transmission, and how fast the diversity increases after infection. Typically, 20 or more sequences per subject give robust results. Moreover, we confirm our theoretical evaluations with analyses of real transmission histories and discuss how our findings should aid in interpreting phylogenetic results.« less

Repeatability and reproducibility of ribotyping and its computer interpretation.

PubMed

Lefresne, Gwénola; Latrille, Eric; Irlinger, Françoise; Grimont, Patrick A D

2004-04-01

Many molecular typing methods are difficult to interpret because their repeatability (within-laboratory variance) and reproducibility (between-laboratory variance) have not been thoroughly studied. In the present work, ribotyping of coryneform bacteria was the basis of a study involving within-gel and between-gel repeatability and between-laboratory reproducibility (two laboratories involved). The effect of different technical protocols, different algorithms, and different software for fragment size determination was studied. Analysis of variance (ANOVA) showed, within a laboratory, that there was no significant added variance between gels. However, between-laboratory variance was significantly higher than within-laboratory variance. This may be due to the use of different protocols. An experimental function was calculated to transform the data and make them compatible (i.e., erase the between-laboratory variance). The use of different interpolation algorithms (spline, Schaffer and Sederoff) was a significant source of variation in one laboratory only. The use of either Taxotron (Institut Pasteur) or GelCompar (Applied Maths) was not a significant source of added variation when the same algorithm (spline) was used. However, the use of Bio-Gene (Vilber Lourmat) dramatically increased the error (within laboratory, within gel) in one laboratory, while decreasing the error in the other laboratory; this might be due to automatic normalization attempts. These results were taken into account for building a database and performing automatic pattern identification using Taxotron. Conversion of the data considerably improved the identification of patterns irrespective of the laboratory in which the data were obtained.

Background Signal as an in Situ Predictor of Dopamine Oxidation Potential: Improving Interpretation of Fast-Scan Cyclic Voltammetry Data.

PubMed

Meunier, Carl J; Roberts, James G; McCarty, Gregory S; Sombers, Leslie A

2017-02-15

Background-subtracted fast-scan cyclic voltammetry (FSCV) has emerged as a powerful analytical technique for monitoring subsecond molecular fluctuations in live brain tissue. Despite increasing utilization of FSCV, efforts to improve the accuracy of quantification have been limited due to the complexity of the technique and the dynamic recording environment. It is clear that variable electrode performance renders calibration necessary for accurate quantification; however, the nature of in vivo measurements can make conventional postcalibration difficult, or even impossible. Analyte-specific voltammograms and scaling factors that are critical for quantification can shift or fluctuate in vivo. This is largely due to impedance changes, and the effects of impedance on these measurements have not been characterized. We have previously reported that the background current can be used to predict electrode-specific scaling factors in situ. In this work, we employ model circuits to investigate the impact of impedance on FSCV measurements. Additionally, we take another step toward in situ electrode calibration by using the oxidation potential of quinones on the electrode surface to accurately predict the oxidation potential for dopamine at any point in an electrochemical experiment, as both are dependent on impedance. The model, validated both in adrenal slice and live brain tissue, enables information encoded in the shape of the background voltammogram to determine electrochemical parameters that are critical for accurate quantification. This improves data interpretation and provides a significant next step toward more automated methods for in vivo data analysis.

Pediatric cervical spine in emergency: radiographic features of normal anatomy, variants and pitfalls.

PubMed

Adib, Omar; Berthier, Emeline; Loisel, Didier; Aubé, Christophe

2016-12-01

Injuries of the cervical spine are uncommon in children. The distribution of injuries, when they do occur, differs according to age. Young children aged less than 8 years usually have upper cervical injuries because of the anatomic and biomechanical properties of their immature spine, whereas older children, whose biomechanics more closely resemble those of adults, are prone to lower cervical injuries. In all cases, the pediatric cervical spine has distinct radiographic features, making the emergency radiological analysis of it difficult. Such features as hypermobility between C2 and C3, pseudospread of the atlas on the axis, pseudosubluxation, the absence of lordosis, anterior wedging of vertebral bodies, pseudowidening of prevertebral soft tissue and incomplete ossification of synchondrosis can be mistaken for traumatic injuries. The interpretation of a plain radiograph of the pediatric cervical spine following trauma must take into account the age of the child, the location of the injury and the mechanism of trauma. Comprehensive knowledge of the specific anatomy and biomechanics of the childhood spine is essential for the diagnosis of suspected cervical spine injury. With it, the physician can, on one hand, differentiate normal physes or synchondroses from pathological fractures or ligamentous disruptions and, on the other, identify any possible congenital anomalies that may also be mistaken for injury. Thus, in the present work, we discuss normal radiological features of the pediatric cervical spine, variants that may be encountered and pitfalls that must be avoided when interpreting plain radiographs taken in an emergency setting following trauma.

Developmental changes in facial expressions of emotions in the strange situation during the second year of life.

PubMed

Izard, Carroll E; Abe, Jo Ann A

2004-09-01

Infants' expressions of discrete emotions were coded during the more stressful episodes (4 through 8) of the Strange Situation at 13 and 18 months. The data showed a significant decrease in full-face expressions (more complex configurations of movements) and a significant increase in component expressions (simpler and more constrained patterns of movements). The authors interpreted this trend as a developmental change toward more regulated and less intense emotions. Consistent with this view, the aggregate index of infants' full-face negative emotion expressions, interpreted as reflecting relatively unregulated intense emotions, correlated significantly with maternal ratings of difficult temperament. The authors discuss alternative interpretations of the findings in terms of changes in reactivity/arousability and the emerging capacity for self-regulation. (c) 2004 APA, all rights reserved

Type-Separated Bytecode - Its Construction and Evaluation

NASA Astrophysics Data System (ADS)

Adler, Philipp; Amme, Wolfram

A lot of constrained systems still use interpreters to run mobile applications written in Java. These interpreters demand for only a few resources. On the other hand, it is difficult to apply optimizations during the runtime of the application. Annotations could be used to achieve a simpler and faster code analysis, which would allow optimizations even for interpreters on constrained devices. Unfortunately, there is no viable way of transporting annotations to and verifying them at the code consumer. In this paper we present type-separated bytecode as an intermediate representation which allows to safely transport annotations as type-extensions. We have implemented several versions of this system and show that it is possible to obtain a performance comparable to Java Bytecode, even though we use a type-separated system with annotations.

Use of global ionospheric maps for HF Doppler measurements interpretation

NASA Astrophysics Data System (ADS)

Petrova, I. R.; Bochkarev, V. V.; Latypov, R. R.

2018-04-01

The HF Doppler technique, a method of measurement of Doppler frequency shift of ionospheric signal, is one of the well-known and widely used techniques of ionosphere research. It allows investigation of various disturbances in the ionosphere. There are different sources of disturbances in the ionosphere such as geomagnetic storms, solar flashes, meteorological effects and atmospheric waves. The HF Doppler technique allows us to find out the influence of earthquakes, explosions and other processes on the ionosphere, which occurs near the Earth. HF Doppler technique has high sensitivity to small frequency variations and high time resolution but interpretation of results is difficult. In this paper, we attempt to use GPS data for Doppler measurements interpretation. Modeling of Doppler frequency shift variations with use of TEC allows separation of ionosphere disturbances of medium scale.

Ambulatory Assessment in Panic Disorder and Specific Phobia

ERIC Educational Resources Information Center

Alpers, Georg W.

2009-01-01

Anxiety disorders are among the most prevalent mental disorders. In panic disorder, panic attacks often occur at unpredictable times, making it difficult to study these episodes in the laboratory. In specific phobias, symptoms occur in very circumscribed situations and specific triggers are sometimes difficult to reproduce in the laboratory.…

Educational principles and techniques for interpreters.

Treesearch

F. David Boulanger; John P. Smith

1973-01-01

Interpretation is in large part education, since it attempts to convey information, concepts, and principles while creating attitude changes and such emotional states as wonder, delight, and appreciation. Although interpreters might profit greatly by formal training in the principles and techniques of teaching, many have not had such training. Some means of making the...

Comparative Sacred Texts and Interactive Interpretation: Another Alternative to the "World Religions" Class

ERIC Educational Resources Information Center

Patton, Laurie L.; Robbins, Vernon K.; Newby, Gordon D.

2009-01-01

In this article we argue for an introductory course in the study of religion that proceeds through interactive interpretation as a responsible form of comparison. Interactive interpretation proceeds provisionally, and encourages students to formulate new questions of the materials instead of making final categories about the materials. We use…

The Interpretive Approach to Religious Education: Challenging Thompson's Interpretation

ERIC Educational Resources Information Center

Jackson, Robert

2012-01-01

In a recent book chapter, Matthew Thompson makes some criticisms of my work, including the interpretive approach to religious education and the research and activity of Warwick Religions and Education Research Unit. Against the background of a discussion of religious education in the public sphere, my response challenges Thompson's account,…

The Impact of Positive and Negative Affect and Issue Framing on Issue Interpretation and Risk Taking.

PubMed

Mittal; Ross

1998-12-01

Two studies examined the influence of transient affective states and issue framing on issue interpretation and risk taking within the context of strategic decision making. In Study 1, participants in whom transient positive or negative affective states were induced by reading a short story showed systematic differences in issue interpretation and risk taking in a strategic decision making context. Compared to negative mood participants, those in a positive mood were more likely to interpret the strategic issue as an opportunity and displayed lower levels of risk taking. Study 2 replicated and extended these results by crossing affective states with threat and opportunity frames. Results showed that framing an issue (as a threat or an opportunity) had a stronger impact on issue interpretation among negative affect participants than among positive affect participants. Affective states also moderated the impact of issue framing on risk taking: the effect of framing on risk-taking was stronger under negative rather than positive affect. These results are interpreted via information-processing and motivational effects of affect on a decision maker. Copyright 1998 Academic Press.

High-Resolution Climate Data Visualization through GIS- and Web-based Data Portals

NASA Astrophysics Data System (ADS)

WANG, X.; Huang, G.

2017-12-01

Sound decisions on climate change adaptation rely on an in-depth assessment of potential climate change impacts at regional and local scales, which usually requires finer resolution climate projections at both spatial and temporal scales. However, effective downscaling of global climate projections is practically difficult due to the lack of computational resources and/or long-term reference data. Although a large volume of downscaled climate data has been make available to the public, how to understand and interpret the large-volume climate data and how to make use of the data to drive impact assessment and adaptation studies are still challenging for both impact researchers and decision makers. Such difficulties have become major barriers preventing informed climate change adaptation planning at regional scales. Therefore, this research will explore new GIS- and web-based technologies to help visualize the large-volume regional climate data with high spatiotemporal resolutions. A user-friendly public data portal, named Climate Change Data Portal (CCDP, http://ccdp.network), will be established to allow intuitive and open access to high-resolution regional climate projections at local scales. The CCDP offers functions of visual representation through geospatial maps and data downloading for a variety of climate variables (e.g., temperature, precipitation, relative humidity, solar radiation, and wind) at multiple spatial resolutions (i.e., 25 - 50 km) and temporal resolutions (i.e., annual, seasonal, monthly, daily, and hourly). The vast amount of information the CCDP encompasses can provide a crucial basis for assessing impacts of climate change on local communities and ecosystems and for supporting better decision making under a changing climate.

Strategy of Surgical Resection for Glioma Based on Intraoperative Functional Mapping and Monitoring

PubMed Central

TAMURA, Manabu; MURAGAKI, Yoshihiro; SAITO, Taiichi; MARUYAMA, Takashi; NITTA, Masayuki; TSUZUKI, Shunsuke; ISEKI, Hiroshi; OKADA, Yoshikazu

2015-01-01

A growing number of papers have pointed out the relationship between aggressive resection of gliomas and survival prognosis. For maximum resection, the current concept of surgical decision-making is in “information-guided surgery” using multimodal intraoperative information. With this, anatomical information from intraoperative magnetic resonance imaging (MRI) and navigation, functional information from brain mapping and monitoring, and histopathological information must all be taken into account in the new perspective for innovative minimally invasive surgical treatment of glioma. Intraoperative neurofunctional information such as neurophysiological functional monitoring takes the most important part in the process to acquire objective visual data during tumor removal and to integrate these findings as digitized data for intraoperative surgical decision-making. Moreover, the analysis of qualitative data and threshold-setting for quantitative data raise difficult issues in the interpretation and processing of each data type, such as determination of motor evoked potential (MEP) decline, underestimation in tractography, and judgments of patient response for neurofunctional mapping and monitoring during awake craniotomy. Neurofunctional diagnosis of false-positives in these situations may affect the extent of resection, while false-negatives influence intra- and postoperative complication rates. Additionally, even though the various intraoperative visualized data from multiple sources contribute significantly to the reliability of surgical decisions when the information is integrated and provided, it is not uncommon for individual pieces of information to convey opposing suggestions. Such conflicting pieces of information facilitate higher-order decision-making that is dependent on the policies of the facility and the priorities of the patient, as well as the availability of the histopathological characteristics from resected tissue. PMID:26185825

Renewing Audience Response in Study of Medieval Literature.

ERIC Educational Resources Information Center

Harrington, David V.

Although modern readers often find the interpretation of medieval literature difficult, they should be encouraged to use their imagination to resolve the dilemmas they encounter. Often, these are the same issues with which medieval audiences had to wrestle and which the poets intended to raise. W. Iser's and H. R. Jauss's principles of…

Exploring Complex Social Phenomena with Computer Simulations

ERIC Educational Resources Information Center

Berson, Ilene R.; Berson, Michael J.

2007-01-01

In social studies classes, there is a longstanding interest in how societies evolve and change over time. However, as stories of the past unfold, it is often difficult to identify a direct link between causes and effects, so students are forced to accept at face value the interpretations of economists, political scientists, historians,…

Vapor-Liquid Equilibria Using the Gibbs Energy and the Common Tangent Plane Criterion

ERIC Educational Resources Information Center

Olaya, Maria del Mar; Reyes-Labarta, Juan A.; Serrano, Maria Dolores; Marcilla, Antonio

2010-01-01

Phase thermodynamics is often perceived as a difficult subject with which many students never become fully comfortable. The Gibbsian geometrical framework can help students to gain a better understanding of phase equilibria. An exercise to interpret the vapor-liquid equilibrium of a binary azeotropic mixture, using the equilibrium condition based…

Teacher Self-Efficacy in Understanding Standards-Based Curriculum: Finding the Gap between Curriculum and Instructional Design

ERIC Educational Resources Information Center

James, Richard A.

2013-01-01

In standards-based education the importance of interpreting standards and effectively embedding them into instructional design is critical in connecting curriculum and instruction. Finding the link between standards and instruction while striving to engage students has proven difficult. Too often instructional design does not meet the cognitive…

A Balancing Act: Interpreting Tragedy at the 9/11 Memorial Museum

ERIC Educational Resources Information Center

Rauch, Noah

2018-01-01

The 9/11 Memorial Museum's docent program offers visitors artifact-based entry-points into a difficult, emotional history. The program's launch raised a host of questions, many centered on how to balance and convey strongly held, often traumatic, and sometimes conflicting experiences with a newly constructed institutional narrative. This article…

Modeling of the Global Water Cycle - Analytical Models

Treesearch

Yongqiang Liu; Roni Avissar

2005-01-01

Both numerical and analytical models of coupled atmosphere and its underlying ground components (land, ocean, ice) are useful tools for modeling the global and regional water cycle. Unlike complex three-dimensional climate models, which need very large computing resources and involve a large number of complicated interactions often difficult to interpret, analytical...

Functional versus non-functional intratumor heterogeneity in cancer

PubMed Central

Williams, Marc J.; Werner, Benjamin; Graham, Trevor A.; Sottoriva, Andrea

2016-01-01

ABSTRACT Next-generation sequencing data from human cancers are often difficult to interpret within the context of tumor evolution. We developed a mathematical model describing the accumulation of mutations under neutral evolutionary dynamics and showed that 323/904 cancers (∼30%) from multiple types were consistent with the neutral model of tumor evolution. PMID:27652316

Postscript: Split Spatial Attention? The Data Remain Difficult to Interpret

ERIC Educational Resources Information Center

Jans, Bert; Peters, Judith C.; De Weerd, Peter

2010-01-01

A growing number of studies claim that spatial attention can be split "on demand" into several, segregated foci of enhanced processing. Intrigued by the theoretical ramifications of this proposal, we analyzed 19 relevant sets of experiments using four methodological criteria. We typically found several methodological limitations in each study that…

Standardizing School Dropout Measures. CPRE Research Report Series.

ERIC Educational Resources Information Center

Williams, Patricia A.

Dropout rates reported by states and school districts are produced by a variety of accounting procedures. Since these rates are difficult to compare and interpret, they fail to correctly measure the dropout rate. A uniform definition of school dropout is needed. The degree of variation was examined by analyzing 21 local definitions. The five…

Genetics at School Level: Addressing the Difficulties

ERIC Educational Resources Information Center

Chu, Yu-Chien; Reid, Norman

2012-01-01

Background: A wide range of studies has offered suggestions why genetics is difficult and some of their key findings are summarised. Underpinning all of this is the way the brain works when handling information. The limitations of working memory capacity offer an interpretation of these difficulties. Purpose: The aim is to confirm that working…

Discovering Reliable Sources of Biochemical Thermodynamic Data to Aid Students' Understanding

ERIC Educational Resources Information Center

Me´ndez, Eduardo; Cerda´, María F.

2016-01-01

Students of physical chemistry in biochemical disciplines need biochemical examples to capture the need, not always understood, of a difficult area in their studies. The use of thermodynamic data in the chemical reference state may lead to incorrect interpretations in the analysis of biochemical examples when the analysis does not include relevant…

Vocabulary Learning at Primary School: A Comparison of EFL and CLIL

ERIC Educational Resources Information Center

Tragant, Elsa; Marsol, Anna; Serrano, Raquel; Llanes, Àngels

2016-01-01

Comparative studies in content and language integrated learning (CLIL) often show CLIL students to be at something of an advantage over their non-CLIL peers. However, such studies are often difficult to interpret given problems of cross-group comparability (different schooling systems, different number of instructional hours, bias attributable to…

Family Involvement in Creative Teaching Practices for All in Small Rural Schools

ERIC Educational Resources Information Center

Vigo Arrazola, Begoña; Soriano Bozalongo, Juana

2015-01-01

Parental involvement is interpreted as a key form of support that can contribute to the establishment of inclusive practices in schools, but this can be difficult in sparsely populated areas. Using ethnographic methods of participant observation, informal conversations and document analysis, this article therefore focuses on family involvement…

Imagining Complex Numbers by Generating, Interpreting and Representing Them

ERIC Educational Resources Information Center

Vozzo, Enzo

2017-01-01

Ever since their serendipitous discovery by Italian mathematicians trying to solve cubic equations in the 16th century, imaginary and complex numbers have been difficult topics to understand. Here the word complex is used to describe something consisting of a number of interconnecting parts. The different parts of a complex number are the…

Data Mining in Earth System Science (DMESS 2011)

Treesearch

Forrest M. Hoffman; J. Walter Larson; Richard Tran Mills; Bhorn-Gustaf Brooks; Auroop R. Ganguly; William Hargrove; et al

2011-01-01

From field-scale measurements to global climate simulations and remote sensing, the growing body of very large and long time series Earth science data are increasingly difficult to analyze, visualize, and interpret. Data mining, information theoretic, and machine learning techniques—such as cluster analysis, singular value decomposition, block entropy, Fourier and...

The Pursuit of Language Appropriate Care: Remote Simultaneous Medical Interpretation Use

ERIC Educational Resources Information Center

Logan, Debra M.

2010-01-01

Background: The U.S. government mandates nurses to deliver linguistically appropriate care to hospital patients. It is difficult for nurses to implement the language mandates because there are 6,912 active living languages spoken in the world. Language barriers appear to place limited English proficient (LEP) patients at increased risk for harm…

Degradation and Characterization of Antimisting Kerosene (AMK).

DTIC Science & Technology

1982-12-01

EXECUTIVE SUMMARY ................................................... I. INTRODUCTION ............................................... 2 II. DEGRADER...P - density Pll-P22 - normal stress difference P12 - shear stress x EXECUTIVE SI-9ARY CSingle pass degradation of Antinmisting Kerosene (ANIK) has...While the jet thrust experiment is more difficult to execute and interpret than flow experiments, a quality control test based on normal stresses would

The Effects of Test Difficulty Manipulation in Computerized Adaptive Testing and Self-Adapted Testing.

ERIC Educational Resources Information Center

Ponsoda, Vicente; Olea, Julio; Rodriguez, Maria Soledad; Revuelta, Javier

1999-01-01

Compared easy and difficult versions of self-adapted tests (SAT) and computerized adapted tests. No significant differences were found among the tests for estimated ability or posttest state anxiety in studies with 187 Spanish high school students, although other significant differences were found. Discusses implications for interpreting test…

Assigning and Combining Probabilities in Single-Case Studies

ERIC Educational Resources Information Center

Manolov, Rumen; Solanas, Antonio

2012-01-01

There is currently a considerable diversity of quantitative measures available for summarizing the results in single-case studies. Given that the interpretation of some of them is difficult due to the lack of established benchmarks, the current article proposes an approach for obtaining further numerical evidence on the importance of the results,…

Presentation and Impact of Experimental Techniques in Chemistry

ERIC Educational Resources Information Center

Sojka, Zbigniew; Che, Michel

2008-01-01

Laboratory and practical courses, where students become familiar with experimental techniques and learn to interpret data and relate them to appropriate theory, play a vital role in chemical education. In the large panoply of currently available techniques, it is difficult to find a rational and easy way to classify the techniques in relation to…

The Role of Perspective Shifts for Processing and Translating Discourse Relations

ERIC Educational Resources Information Center

Zufferey, Sandrine; Gygax, Pascal M.

2016-01-01

Previous research has suggested that some discourse relations are easier to convey implicitly than others due to cognitive biases in the interpretation of discourse. In this article we argue that relations involving a perspective shift, such as confirmation relations, are difficult to convey implicitly. We assess this claim with two empirical…

[Labeling of vitamin and mineral supplements: a revision of the federal normative regulations].

PubMed

de Carvalho, Patricia Borges; Araújo, Wilma Maria Coelho

2008-04-01

In Brazil, there is a steadily increasing offer and demand for products on the basis of vitamins and minerals. According to Brazilian law, the differences in the dosages offered to the consumer in each product are the parameter for its classification as alimentary supplement or medicament. The limit between these two concepts, however, is confusing and lacks clearness. Considering the risk posed by imprudent consumption of such products and seeking to facilitate the interpretation and consolidation of the norms dealing with vitamin and mineral products as well as to create the basis for a master's degree dissertation, a bibliographical survey and evaluation of the entire juridical basis regarding the labeling of these products was conducted. It was concluded that the normative regulations are extensive, complex and of difficult understanding, with a great number of norms dealing with the same subject issued by different authorities. These norms are not consolidated leading to difficult interpretation by retailers, health professionals and consumers and even to failures in the application of these norms by the control authorities. Suggestions are made for helping to correct the failures identified in the study.

Monitoring challenges and innovative ideas

DOE Office of Scientific and Technical Information (OSTI.GOV)

O'Neill, R.V.; Hunsaker, C.T.; Levine, D.A.

1990-01-01

Monitoring programs are difficult to design even when they focus on specific problems. Ecosystems are complex, and it is often impossible to predetermine what aspects of system structure or dynamics will respond to a specific insult. It is equally difficult to interpret whether a response is a stabilizing compensatory mechanism or a real loss of capacity to maintain the ecosystem. The problems are compounded in a broad monitoring program designed to assess ecosystem health'' at regional and continental scales. It is challenging in the extreme to monitor ecosystem response, at any scale, to past insults as well as an unknownmore » future array of impacts. The present paper will examine some of the fundamental issues and challenges raised by large-scale monitoring efforts. The challenges will serve as a framework and as an excuse to discuss several important topics in more detail. Following the discussion of challenges, we suggest some basic innovations that could be important across a range of monitoring programs. The innovations include integrative measures, innovative methodology, and creative interpretation. 59 refs., 1 tab.« less

Fully Bayesian tests of neutrality using genealogical summary statistics.

PubMed

Drummond, Alexei J; Suchard, Marc A

2008-10-31

Many data summary statistics have been developed to detect departures from neutral expectations of evolutionary models. However questions about the neutrality of the evolution of genetic loci within natural populations remain difficult to assess. One critical cause of this difficulty is that most methods for testing neutrality make simplifying assumptions simultaneously about the mutational model and the population size model. Consequentially, rejecting the null hypothesis of neutrality under these methods could result from violations of either or both assumptions, making interpretation troublesome. Here we harness posterior predictive simulation to exploit summary statistics of both the data and model parameters to test the goodness-of-fit of standard models of evolution. We apply the method to test the selective neutrality of molecular evolution in non-recombining gene genealogies and we demonstrate the utility of our method on four real data sets, identifying significant departures of neutrality in human influenza A virus, even after controlling for variation in population size. Importantly, by employing a full model-based Bayesian analysis, our method separates the effects of demography from the effects of selection. The method also allows multiple summary statistics to be used in concert, thus potentially increasing sensitivity. Furthermore, our method remains useful in situations where analytical expectations and variances of summary statistics are not available. This aspect has great potential for the analysis of temporally spaced data, an expanding area previously ignored for limited availability of theory and methods.

Addressing the “Other” Health Literacy Competencies—Knowledge, Dispositions, and Oral/Aural Communication: Development of TALKDOC, an Intervention Assessment Tool

PubMed Central

HELITZER, DEBORAH; HOLLIS, CHRISTINE; SANDERS, MARGARET; ROYBAL, SUZANNE

2013-01-01

Most health literacy assessments evaluate literacy skills including reading, writing; numeracy and interpretation of tables, graphs, diagrams and charts. Some assess understanding of health systems, and the ability to adequately apply one’s skills to specific health-related tasks or demands in health situations. However, to achieve functional health literacy, the ability to “obtain, process, and understand basic health information and services needed to make appropriate health decisions,” other health literacy dimensions should be assessed: a person’s knowledge and attitudes about a health issue affects his or her ability to and interest in participating in his or her own care. In patient care settings, the abilities to listen, ask questions and check one’s understanding are crucial to making appropriate decisions and carrying out instructions. Although literacy is a skill associated with educational attainment and therefore difficult to change in a short time, health education interventions can address health literacy domains such as knowledge, attitudes and oral communication skills. For this reason, an instrument that can assess these constructs is a valuable part of a health educator’s toolbox. The authors describe the development and process and outcomes of testing a novel instrument targeted to assess HPV and cervical cancer health literacy competencies, TALKDOC, including its validation with the Health Activities Literacy Scale. PMID:23030568

Law machines: scale models, forensic materiality and the making of modern patent law.

PubMed

Pottage, Alain

2011-10-01

Early US patent law was machine made. Before the Patent Office took on the function of examining patent applications in 1836, questions of novelty and priority were determined in court, within the forum of the infringement action. And at all levels of litigation, from the circuit courts up to the Supreme Court, working models were the media through which doctrine, evidence and argument were made legible, communicated and interpreted. A model could be set on a table, pointed at, picked up, rotated or upended so as to display a point of interest to a particular audience within the courtroom, and, crucially, set in motion to reveal the 'mode of operation' of a machine. The immediate object of demonstration was to distinguish the intangible invention from its tangible embodiment, but models also'machined' patent law itself. Demonstrations of patent claims with models articulated and resolved a set of conceptual tensions that still make the definition and apprehension of the invention difficult, even today, but they resolved these tensions in the register of materiality, performativity and visibility, rather than the register of conceptuality. The story of models tells us something about how inventions emerge and subsist within the context of patent litigation and patent doctrine, and it offers a starting point for renewed reflection on the question of how technology becomes property.

A Phenomenological Two-Ribbon Model for Spatially Unresolved Observations of Stellar Flares

NASA Astrophysics Data System (ADS)

Kowalski, Adam

2018-06-01

Solar flares and flares that occur in much more magnetically active stars share some striking properties, such as the observed Neupert effect. However, stellar flares with the most impressive multi-wavelength data sets are typically much more energetic than solar flares, thus making robust connections difficult to establish. Whereas solar data have the advantage of high spatial resolution providing critical information about the development of flare ribbons, the major advantage of stellar flare data is the readily available broad-wavelength coverage of the white-light radiation and the Balmer jump spectral region. Due to the lack of direct spatial resolution for stellar flares and rarely coverage of the Balmer jump region for solar flares, it is not clear how to make a direct comparison. I will present a new method for modeling stellar flares based on high spatial resolution information of solar flare two-ribbon development for comparisons of the physics of their observed phenomena, such as the red-wing asymmetries in chromospheric lines and the white-light continuum radiation. The new modeling method combines aspects of "multi-thread" modeling and 1D radiative-hydrodynamic modeling. Our algorithm is important for interpreting the impulsive phase of superflares in young G dwarfs in Kepler and understanding how hour-long decay timescales are attained in the gradual phase of some very energetic stellar flares.

Nascent RNA kinetics: Transient and steady state behavior of models of transcription

NASA Astrophysics Data System (ADS)

Choubey, Sandeep

2018-02-01

Regulation of transcription is a vital process in cells, but mechanistic details of this regulation still remain elusive. The dominant approach to unravel the dynamics of transcriptional regulation is to first develop mathematical models of transcription and then experimentally test the predictions these models make for the distribution of mRNA and protein molecules at the individual cell level. However, these measurements are affected by a multitude of downstream processes which make it difficult to interpret the measurements. Recent experimental advancements allow for counting the nascent mRNA number of a gene as a function of time at the single-inglr cell level. These measurements closely reflect the dynamics of transcription. In this paper, we consider a general mechanism of transcription with stochastic initiation and deterministic elongation and probe its impact on the temporal behavior of nascent RNA levels. Using techniques from queueing theory, we derive exact analytical expressions for the mean and variance of the nascent RNA distribution as functions of time. We apply these analytical results to obtain the mean and variance of nascent RNA distribution for specific models of transcription. These models of initiation exhibit qualitatively distinct transient behaviors for both the mean and variance which further allows us to discriminate between them. Stochastic simulations confirm these results. Overall the analytical results presented here provide the necessary tools to connect mechanisms of transcription initiation to single-cell measurements of nascent RNA.

Investigation of prefrontal cerebral hemodynamics during quantitative autonomic testing using NIRS (Conference Presentation)

NASA Astrophysics Data System (ADS)

Phillips, Zephaniah; Paik, Seung-Ho; Kim, Yoohwan; Kim, Byung-Jo; Choi, Youngwoon; Kim, Beop-Min

2017-02-01

In this work, we analyzed the clinical applicability of NIRS for use during Quantitative Autonomic Testing (QAT). QAT is a protocol consisting of deep breathing, Valsalva maneuver, and tilt table examination. It is used to diagnose a patient with disorders of the autonomic nervous system (ANS). Disorders of ANS includes orthostatic hyper/hypotension, vasovagal syncope, and postural orthostatic tachycardia syndrome. The results of QAT are typically analyzed with the use of blood pressure and heart rate data, however these metrics may be influenced by factors such as arrhythmia, making the data interpretation and diagnosis difficult for clinicians. We tested our custom built 108-channel NIRS probe on 26 elderly patients during the QAT protocol with various ANS disorders. We found that prefrontal cerebral oxygenation correlated well with blood pressure and heart rate changes for all three tasks, making it a clinically feasible tool for observing ANS functionality. During the Valsalva maneuver, we observed a longer delayed and lower amplitude response of cerebral oxygenation to the prefrontal area in orthostatic intolerant patients. During the tilt table examination, we saw a larger response in cerebral oxygenation and less equal transient cerebral oxygenation during tilt up and tilt down in tilt table examinations that were positive (unhealthy), compared to tilt table examinations that were negative (healthy). Overall, our study showcases NIRS as an enhanced tool for understanding ANS disorders.

The potential for non-invasive study of mummies: validation of the use of computerized tomography by post factum dissection and histological examination of a 17th century female Korean mummy

PubMed Central

Lim, Do-Seon; Lee, In Sun; Choi, Ki-Ju; Lee, Soong Deok; Oh, Chang Seok; Kim, Yi-Suk; Bok, Gi Dae; Kim, Myeung Ju; Yi, Yang Su; Lee, Eun-Joo; Shin, Dong Hoon

2008-01-01

The socio-cultural antipathies of some descendants with regard to invasive examinations of age-old human remains make permission for dissection of Korean mummies of the Joseon Dynasty (1392–1910) difficult to obtain. Overcoming this obstacle necessitated the use of non-invasive techniques, such as multi-detector computerized tomography (MDCT) and endoscopic examination, enabling determination of the preservation status of internal organs of mummies without significantly damaging the mummies themselves. However, MDCT alone cannot clearly differentiate specific mummified organs. Therefore, in much the same way as diagnostic radiologists make their MDCT readings on living patients more reliable by means of comparison with accumulated post-factum data from autopsies or histological studies, examinations of mummies by invasive techniques should not be decried as mere destruction of age-old human remains. Rather, providing that due permission from descendants and/or other relevant authorities can be obtained, dissection and histological examination should be performed whenever opportunities arise. Therefore, in this study, we compared the radiological data acquired from a 17th century mummy with our dissection results for the same subject. As accumulation of this kind of data could be very crucial for correct interpretation of MDCT findings on Korean mummies, we will perform similar trials on other Korean mummies found in forthcoming days if conditions permit. PMID:19014355

Plant Uptake of Atmospheric Carbonyl Sulfide in Coast Redwood Forests

NASA Astrophysics Data System (ADS)

Campbell, J. E.; Whelan, M. E.; Berry, J. A.; Hilton, T. W.; Zumkehr, A.; Stinecipher, J.; Lu, Y.; Kornfeld, A.; Seibt, U.; Dawson, T. E.; Montzka, S. A.; Baker, I. T.; Kulkarni, S.; Wang, Y.; Herndon, S. C.; Zahniser, M. S.; Commane, R.; Loik, M. E.

2017-12-01

The future resilience of coast redwoods (Sequoia sempervirens) is now of critical concern due to the detection of a 33% decline in California coastal fog over the 20th century. However, ecosystem-scale measurements of photosynthesis and stomatal conductance are challenging in coast redwood forests, making it difficult to anticipate the impacts of future changes in fog. To address this methodological problem, we explore coastal variations in atmospheric carbonyl sulfide (COS or OCS), which could potentially be used as a tracer of these ecosystem processes. We conducted atmospheric flask campaigns in coast redwood sites, sampling at surface heights and in the canopy ( 70 m), at the University of California Landels-Hill Big Creek Reserve and Big Basin State Park. We simulated COS atmosphere-biosphere exchange with a high-resolution 3-D model to interpret these data. Flask measurements indicated a persistent daytime drawdown between the coast and the downwind forest (45 ± 6 ppt COS) that is consistent with the expected relationship between COS plant uptake, stomatal conductance, and gross primary production. Other sources and sinks of COS that could introduce noise to the COS tracer technique (soils, anthropogenic activity, nocturnal plant uptake, and surface hydrolysis on leaves) are likely to be small relative to daytime COS plant uptake. These results suggest that COS measurements may be useful for making ecosystem-scale estimates of carbon, water, and energy exchange in coast redwood forests.

A multifactorial obesity model developed from nationwide public health exposome data and modern computational analyses.

PubMed

Gittner, LisaAnn S; Kilbourne, Barbara J; Vadapalli, Ravi; Khan, Hafiz M K; Langston, Michael A

Obesity is both multifactorial and multimodal, making it difficult to identify, unravel and distinguish causative and contributing factors. The lack of a clear model of aetiology hampers the design and evaluation of interventions to prevent and reduce obesity. Using modern graph-theoretical algorithms, we are able to coalesce and analyse thousands of inter-dependent variables and interpret their putative relationships to obesity. Our modelling is different from traditional approaches; we make no a priori assumptions about the population, and model instead based on the actual characteristics of a population. Paracliques, noise-resistant collections of highly-correlated variables, are differentially distilled from data taken over counties associated with low versus high obesity rates. Factor analysis is then applied and a model is developed. Latent variables concentrated around social deprivation, community infrastructure and climate, and especially heat stress were connected to obesity. Infrastructure, environment and community organisation differed in counties with low versus high obesity rates. Clear connections of community infrastructure with obesity in our results lead us to conclude that community level interventions are critical. This effort suggests that it might be useful to study and plan interventions around community organisation and structure, rather than just the individual, to combat the nation's obesity epidemic. Copyright © 2017 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.

Multi-layered foil capture of micrometeoroids and orbital debris in low Earth orbit

NASA Astrophysics Data System (ADS)

Kearsley, A.; Graham, G.

Much of our knowledge concerning the sub-millimetre orbital debris population that poses a threat to orbiting satellites has been gleaned from examination of surfaces retrieved and subsequently analysed as part of post-flight investigations. The preservation of the hypervelocity impact-derived remnants located on these surfaces is very variable, whether of space debris or micrometeoroid origin. Whilst glass and metallic materials show highly visible impact craters when examined using optical and electron microscopes, complex mixing between the target material and the impacting particle may make unambiguous interpretation of the impactor origin difficult or impossible. Our recent detailed examination of selected multi-layered insulation (MLI) foils from the ISAS Space Flyer Unit (SFU), and our preliminary study of NASA's Trek blanket, exposed on the Mir station, show that these constructions have the potential to preserve abundant residue material of a quality sufficient for detailed analysis. Although there are still limitations on the recognition of certain sources of orbital debris, the foils complement the metal and glass substrates. We suggest that a purpose-built multi-layered foil structure may prove to be extremely effective for rapid collection and unambiguous analysis of impact- derived residues. Such a collector could be used an environmental monitor for ISS, as it would have low mass, high durability, easy deployment, recovery and storage, making it an economically viable and attractive option.

Three-dimensional tertiary structure of yeast phenylalanine transfer RNA

NASA Technical Reports Server (NTRS)

Kim, S. H.; Sussman, J. L.; Suddath, F. L.; Quigley, G. J.; Mcpherson, A.; Wang, A. H. J.; Seeman, N. C.; Rich, A.

1974-01-01

Results of an analysis and interpretation of a 3-A electron density map of yeast phenylalanine transfer RNA. Some earlier detailed assignments of nucleotide residues to electron density peaks are found to be in error, even though the overall tracing of the backbone conformation of yeast phenylalanine transfer RNA was generally correct. A new, more comprehensive interpretation is made which makes it possible to define the tertiary interactions in the molecule. The new interpretation makes it possible to visualize a number of tertiary interactions which not only explain the structural role of most of the bases which are constant in transfer RNAs, but also makes it possible to understand in a direct and simple fashion the chemical modification data on transfer RNA. In addition, this pattern of tertiary interactions provides a basis for understanding the general three-dimensional folding of all transfer RNA molecules.

Multi-objective decision-making under uncertainty: Fuzzy logic methods

NASA Technical Reports Server (NTRS)

Hardy, Terry L.

1994-01-01

Selecting the best option among alternatives is often a difficult process. This process becomes even more difficult when the evaluation criteria are vague or qualitative, and when the objectives vary in importance and scope. Fuzzy logic allows for quantitative representation of vague or fuzzy objectives, and therefore is well-suited for multi-objective decision-making. This paper presents methods employing fuzzy logic concepts to assist in the decision-making process. In addition, this paper describes software developed at NASA Lewis Research Center for assisting in the decision-making process. Two diverse examples are used to illustrate the use of fuzzy logic in choosing an alternative among many options and objectives. One example is the selection of a lunar lander ascent propulsion system, and the other example is the selection of an aeration system for improving the water quality of the Cuyahoga River in Cleveland, Ohio. The fuzzy logic techniques provided here are powerful tools which complement existing approaches, and therefore should be considered in future decision-making activities.

CNV-WebStore: online CNV analysis, storage and interpretation.

PubMed

Vandeweyer, Geert; Reyniers, Edwin; Wuyts, Wim; Rooms, Liesbeth; Kooy, R Frank

2011-01-05

Microarray technology allows the analysis of genomic aberrations at an ever increasing resolution, making functional interpretation of these vast amounts of data the main bottleneck in routine implementation of high resolution array platforms, and emphasising the need for a centralised and easy to use CNV data management and interpretation system. We present CNV-WebStore, an online platform to streamline the processing and downstream interpretation of microarray data in a clinical context, tailored towards but not limited to the Illumina BeadArray platform. Provided analysis tools include CNV analsyis, parent of origin and uniparental disomy detection. Interpretation tools include data visualisation, gene prioritisation, automated PubMed searching, linking data to several genome browsers and annotation of CNVs based on several public databases. Finally a module is provided for uniform reporting of results. CNV-WebStore is able to present copy number data in an intuitive way to both lab technicians and clinicians, making it a useful tool in daily clinical practice.

Dissecting the effects of nitrate, sucrose and osmotic potential on Arabidopsis root and shoot system growth in laboratory assays

PubMed Central

Roycewicz, Peter; Malamy, Jocelyn E.

2012-01-01

Studying the specific effects of water and nutrients on plant development is difficult because changes in a single component can often trigger multiple response pathways. Such confounding issues are prevalent in commonly used laboratory assays. For example, increasing the nitrate concentration in growth media alters both nitrate availability and osmotic potential. In addition, it was recently shown that a change in the osmotic potential of media alters the plant's ability to take up other nutrients such as sucrose. It can also be difficult to identify the initial target tissue of a particular environmental cue because there are correlated changes in development of many organs. These growth changes may be coordinately regulated, or changes in development of one organ may trigger changes in development of another organ as a secondary effect. All these complexities make analyses of plant responses to environmental factors difficult to interpret. Here, we review the literature on the effects of nitrate, sucrose and water availability on root system growth and discuss the mechanisms underlying these effects. We then present experiments that examine the impact of nitrate, sucrose and water on root and shoot system growth in culture using an approach that holds all variables constant except the one under analysis. We found that while all three factors also alter root system size, changes in sucrose and osmotic potential also altered shoot system size. In contrast, we found that, when osmotic effects are controlled, nitrate specifically inhibits root system growth while having no effect on shoot system growth. This effectively decreases the root : shoot ratio. Alterations in root : shoot ratio have been widely observed in response to nitrogen starvation, where root growth is selectively increased, but the present results suggest that alterations in this ratio can be triggered across a wide spectrum of nitrate concentrations. PMID:22527391

Behavioral genetics and criminal responsibility at the courtroom.

PubMed

Tatarelli, Roberto; Del Casale, Antonio; Tatarelli, Caterina; Serata, Daniele; Rapinesi, Chiara; Sani, Gabriele; Kotzalidis, Georgios D; Girardi, Paolo

2014-04-01

Several questions arise from the recent use of behavioral genetic research data in the courtroom. Ethical issues concerning the influence of biological factors on human free will, must be considered when specific gene patterns are advocated to constrain court's judgment, especially regarding violent crimes. Aggression genetics studies are both difficult to interpret and inconsistent, hence, in the absence of a psychiatric diagnosis, genetic data are currently difficult to prioritize in the courtroom. The judge's probabilistic considerations in formulating a sentence must take into account causality, and the latter cannot be currently ensured by genetic data. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Simple Data Sets for Distinct Basic Summary Statistics

ERIC Educational Resources Information Center

Lesser, Lawrence M.

2011-01-01

It is important to avoid ambiguity with numbers because unfortunate choices of numbers can inadvertently make it possible for students to form misconceptions or make it difficult for teachers to tell if students obtained the right answer for the right reason. Therefore, it is important to make sure when introducing basic summary statistics that…

SPATIALLY RESOLVED SPECTROSCOPY OF EUROPA: THE DISTINCT SPECTRUM OF LARGE-SCALE CHAOS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fischer, P. D.; Brown, M. E.; Hand, K. P., E-mail: pfischer@caltech.edu

2015-11-15

We present a comprehensive analysis of spatially resolved moderate spectral resolution near-infrared spectra obtained with the adaptive optics system at the Keck Observatory. We identify three compositionally distinct end member regions: the trailing hemisphere bullseye, the leading hemisphere upper latitudes, and a third component associated with leading hemisphere chaos units. We interpret the composition of the three end member regions to be dominated by irradiation products, water ice, and evaporite deposits or salt brines, respectively. The third component is associated with geological features and distinct from the geography of irradiation, suggesting an endogenous identity. Identifying the endogenous composition is ofmore » particular interest for revealing the subsurface composition. However, its spectrum is not consistent with linear mixtures of the salt minerals previously considered relevant to Europa. The spectrum of this component is distinguished by distorted hydration features rather than distinct spectral features, indicating hydrated minerals but making unique identification difficult. In particular, it lacks features common to hydrated sulfate minerals, challenging the traditional view of an endogenous salty component dominated by Mg-sulfates. Chloride evaporite deposits are one possible alternative.« less

Warthin tumor with signet-ring cell features as a pitfall in salivary gland cytopathology.

PubMed

Bellevicine, Claudio; Iaccarino, Antonino; Malapelle, Umberto; Troncone, Giancarlo

2013-01-01

Warthin tumor (WT) is a common parotid lesion reliably diagnosed by fine-needle aspiration (FNA). Worrisome metaplastic changes may occur in WT. Their interpretation as mucoepidermoid carcinoma represents a diagnostic pitfall. Moreover, WT and mucoepidermoid carcinoma may coexist, making this distinction difficult. So it is worthwhile to report unusual WT features. We describe a WT with signet-ring cells (SRCs). A 61-year-old male presenting with a 3.6-cm right parotid gland mass underwent FNA with rapid on-site evaluation. DiffQuik-stained smears showed groups of oncocytic cells with abundant granular cytoplasm in a background rich with debris, foamy macrophages and lymphoid cells. SRCs were observed on Papanicolaou-stained smears prepared from a second pass. A WT with SRC features was diagnosed. Histology revealed a WT with post-FNA infarctual changes. To avoid false-positive diagnoses, the cytopathologist should be aware that SRC features may occur in WT. The concomitant presence of oncocytes and SRCs is useful to correctly diagnose this unusual WT variant. Copyright © 2013 S. Karger AG, Basel.

Value for money of changing healthcare services? Economic evaluation of quality improvement

PubMed Central

Severens, J

2003-01-01



 There are many instances of perceived or real inefficiencies in health service delivery. Both healthcare providers and policy makers need to know the impact and cost of applying strategies to change the behaviour of individuals or organisations. Quality improvement or implementation research is concerned with evaluating the methods of behavioural change. Addressing inefficiencies in healthcare services raises a series of issues, beginning with how inefficiency itself should be defined. The basic concepts of cost analysis and economic evaluations are explained and a model for working through the economic issues of quality improvement is discussed. This model combines the costs and benefits of corrected inefficiency with the costs and degree of behavioural change achieved by a quality improvement method in the policy maker's locality. It shows why it may not always be cost effective for policy makers to address suboptimal behaviour. Both the interpretation of quality improvement research findings and their local application need careful consideration. The limited availability of applicable quality improvement research may make it difficult to provide robust advice on the value for money of many behavioural quality improvement strategies. PMID:14532369

Characterising switching behaviour in perceptual multi-stability.

PubMed

Denham, Susan; Bendixen, Alexandra; Mill, Robert; Tóth, Dénes; Wennekers, Thomas; Coath, Martin; Bőhm, Tamás; Szalardy, Orsolya; Winkler, István

2012-09-15

When people experience an unchanging sensory input for a long period of time, their perception tends to switch stochastically and unavoidably between alternative interpretations of the sensation; a phenomenon known as perceptual bi-stability or multi-stability. The huge variability in the experimental data obtained in such paradigms makes it difficult to distinguish typical patterns of behaviour, or to identify differences between switching patterns. Here we propose a new approach to characterising switching behaviour based upon the extraction of transition matrices from the data, which provide a compact representation that is well-understood mathematically. On the basis of this representation we can characterise patterns of perceptual switching, visualise and simulate typical switching patterns, and calculate the likelihood of observing a particular switching pattern. The proposed method can support comparisons between different observers, experimental conditions and even experiments. We demonstrate the insights offered by this approach using examples from our experiments investigating multi-stability in auditory streaming. However, the methodology is generic and thus widely applicable in studies of multi-stability in any domain. Copyright © 2012 Elsevier B.V. All rights reserved.

Synthesis of linear regression coefficients by recovering the within-study covariance matrix from summary statistics.

PubMed

Yoneoka, Daisuke; Henmi, Masayuki

2017-06-01

Recently, the number of regression models has dramatically increased in several academic fields. However, within the context of meta-analysis, synthesis methods for such models have not been developed in a commensurate trend. One of the difficulties hindering the development is the disparity in sets of covariates among literature models. If the sets of covariates differ across models, interpretation of coefficients will differ, thereby making it difficult to synthesize them. Moreover, previous synthesis methods for regression models, such as multivariate meta-analysis, often have problems because covariance matrix of coefficients (i.e. within-study correlations) or individual patient data are not necessarily available. This study, therefore, proposes a brief explanation regarding a method to synthesize linear regression models under different covariate sets by using a generalized least squares method involving bias correction terms. Especially, we also propose an approach to recover (at most) threecorrelations of covariates, which is required for the calculation of the bias term without individual patient data. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

Radiation exposure and breast cancer: lessons from Chernobyl.

PubMed

Ogrodnik, Aleksandra; Hudon, Tyler W; Nadkarni, Prakash M; Chandawarkar, Rajiv Y

2013-04-01

The lessons learned from the Chernobyl disaster have become increasingly important after the second anniversary of the Fukushima, Japan nuclear accident. Historically, data from the Chernobyl reactor accident 27 years ago demonstrated a strong correlation with thyroid cancer, but data on the radiation effects of Chernobyl on breast cancer incidence have remained inconclusive. We reviewed the published literature on the effects of the Chernobyl disaster on breast cancer incidence, using Medline and Scopus from the time of the accident to December of 2010. Our findings indicate limited data and statistical flaws. Other confounding factors, such as discrepancies in data collection, make interpretation of the results from the published literature difficult. Re-analyzing the data reveals that the incidence of breast cancer in Chernobyl-disaster-exposed women could be higher than previously thought. We have learned little of the consequences of radiation exposure at Chernobyl except for its effects on thyroid cancer incidence. Marking the 27th year after the Chernobyl event, this report sheds light on a specific, crucial and understudied aspect of the results of radiation from a gruesome nuclear power plant disaster.

[Artificial intelligence in medicine: limits and obstacles.

PubMed

Santoro, Eugenio

2017-12-01

Data scientists and physicians are starting to use artificial intelligence (AI) even in the medical field in order to better understand the relationships among the huge amount of data coming from the great number of sources today available. Through the data interpretation methods made available by the recent AI tools, researchers and AI companies have focused on the development of models allowing to predict the risk of suffering from a specific disease, to make a diagnosis, and to recommend a treatment that is based on the best and most updated scientific evidence. Even if AI is used to perform unimaginable tasks until a few years ago, the awareness about the ongoing revolution has not yet spread through the medical community for several reasons including the lack of evidence about safety, reliability and effectiveness of these tools, the lack of regulation accompanying hospitals in the use of AI by health care providers, the difficult attribution of liability in case of errors and malfunctions of these systems, and the ethical and privacy questions that they raise and that, as of today, are still unanswered.

Assessment of oxidative stress in serum by d-ROMs test.

PubMed

Kilk, K; Meitern, R; Härmson, O; Soomets, U; Hõrak, P

2014-08-01

Assessment of oxidative stress is an important but technically challenging procedure in medical and biological research. The reactive oxygen metabolites (d-ROMs) test is a simple assay marketed for analyzing the total amount of hydroperoxides in serum via the Fenton's reaction. Earlier reports have raised a suspicion that a part of the signal detected in the assay comes from sources other than metabolites generated by oxidative stress. The aim of this study was to identify which serum components interfere with the d-ROMs signal. By application of sodium azide, ethylenediaminetetraacetic acid, sodium dodecylsulphate, varying temperature, and spiking endogenous substances we demonstrate that in the case of mammalian sera the assay determines ceruloplasmin (CP) activity with potential interferences from hydroperoxides, iron level, thiols, and albumin. In sera of avian species hydroperoxides contribute more to the test outcome, but the CP part is insensitive to inhibition by azide. In conclusion, this assay has deficiencies in terms of detecting realistic concentrations of hydroperoxides, is mostly measuring CP and is also interfered with other serum components, making it very difficult to interpret in most biological systems.

SNPhylo: a pipeline to construct a phylogenetic tree from huge SNP data.

PubMed

Lee, Tae-Ho; Guo, Hui; Wang, Xiyin; Kim, Changsoo; Paterson, Andrew H

2014-02-26

Phylogenetic trees are widely used for genetic and evolutionary studies in various organisms. Advanced sequencing technology has dramatically enriched data available for constructing phylogenetic trees based on single nucleotide polymorphisms (SNPs). However, massive SNP data makes it difficult to perform reliable analysis, and there has been no ready-to-use pipeline to generate phylogenetic trees from these data. We developed a new pipeline, SNPhylo, to construct phylogenetic trees based on large SNP datasets. The pipeline may enable users to construct a phylogenetic tree from three representative SNP data file formats. In addition, in order to increase reliability of a tree, the pipeline has steps such as removing low quality data and considering linkage disequilibrium. A maximum likelihood method for the inference of phylogeny is also adopted in generation of a tree in our pipeline. Using SNPhylo, users can easily produce a reliable phylogenetic tree from a large SNP data file. Thus, this pipeline can help a researcher focus more on interpretation of the results of analysis of voluminous data sets, rather than manipulations necessary to accomplish the analysis.

Automatic query formulations in information retrieval.

PubMed

Salton, G; Buckley, C; Fox, E A

1983-07-01

Modern information retrieval systems are designed to supply relevant information in response to requests received from the user population. In most retrieval environments the search requests consist of keywords, or index terms, interrelated by appropriate Boolean operators. Since it is difficult for untrained users to generate effective Boolean search requests, trained search intermediaries are normally used to translate original statements of user need into useful Boolean search formulations. Methods are introduced in this study which reduce the role of the search intermediaries by making it possible to generate Boolean search formulations completely automatically from natural language statements provided by the system patrons. Frequency considerations are used automatically to generate appropriate term combinations as well as Boolean connectives relating the terms. Methods are covered to produce automatic query formulations both in a standard Boolean logic system, as well as in an extended Boolean system in which the strict interpretation of the connectives is relaxed. Experimental results are supplied to evaluate the effectiveness of the automatic query formulation process, and methods are described for applying the automatic query formulation process in practice.

3D Magnetic Reconnection

NASA Astrophysics Data System (ADS)

Parnell, Clare E.; Maclean, Rhona C.; Haynes, Andrew L.; Galsgaard, Klaus

2011-08-01

Magnetic reconnection is an important process that is prevalent in a wide range of astrophysical bodies. It is the mechanism that permits magnetic fields to relax to a lower energy state through the global restructuring of the magnetic field and is thus associated with a range of dynamic phenomena such as solar flares and CMEs. The characteristics of three-dimensional reconnection are reviewed revealing how much more diverse it is than reconnection in two dimensions. For instance, three-dimensional reconnection can occur both in the vicinity of null points, as well as in the absence of them. It occurs continuously and continually throughout a diffusion volume, as opposed to at a single point, as it does in two dimensions. This means that in three-dimensions field lines do not reconnect in pairs of lines making the visualisation and interpretation of three-dimensional reconnection difficult. By considering particular numerical 3D magnetohydrodynamic models of reconnection, we consider how magnetic reconnection can lead to complex magnetic topologies and current sheet formation. Indeed, it has been found that even simple interactions, such as the emergence of a flux tube, can naturally give rise to `turbulent-like' reconnection regions.

Site Alteration Effects from Rocket Exhaust Impingement During a Simulated Viking Mars Landing. Part 2: Chemical and Biological Site Alteration

NASA Technical Reports Server (NTRS)

Husted, R. R.; Smith, I. D.; Fennessey, P. V.

1977-01-01

Chemical and biological alteration of a Mars landing site was investigated experimentally and analytically. The experimental testing was conducted using a specially designed multiple nozzle configuration consisting of 18 small bell nozzles. The chemical test results indicate that an engine using standard hydrazine fuel will contaminate the landing site with ammonia (50-500ppm), nitrogen (5-50ppm), aniline (0.01-0.5ppm), hydrogen cyanide (0.01-0.5ppm), and water. A purified fuel, with impurities (mostly aniline) reduced by a factor of 50-100, limits the amount of hydrogen cyanide and aniline to below detectable limits for the Viking science investigations and leaves the amounts of ammonia, nitrogen, and water in the soil unchanged. The large amounts of ammonia trapped in the soil will make interpretation of the organic analysis investigation results more difficult. The biological tests indicate that the combined effects of plume gases, surface heating, surface erosion, and gas composition resulting from the retrorockets will not interfere with the Viking biology investigation.

Cultural Determinants of Help Seeking: A model for research and practice

PubMed Central

2007-01-01

Increasing access to, and use of, health promotion strategies and health care services for diverse cultural groups is a National priority. While theories about the structural determinants of help seeking have received empirical testing, studies about cultural determinants have been primarily descriptive, making theoretical and empirical analysis difficult. This article synthesizes concepts and research by the author and others from diverse disciplines to develop the mid-range theoretical model called the Cultural Determinants of Help Seeking (CDHS). The multidimensional construct of culture, which defines the iterative dimensions of ideology, political-economy, practice and the body, is outlined. The notion of cultural models of wellness and illness as cognitive guides for perception, emotion and behavior; as well as the synthesized concept of idioms of wellness and distress, are introduced. Next, the CDHS theory proposes that sign and symptom perception, the interpretation of their meaning and the dynamics of the social distribution of resources, are all shaped by cultural models. Then, the CDHS model is applied to practice using research with Asians. Lastly, implications for research and practice are discussed. PMID:19999745

The effectiveness of physical and organisational ergonomic interventions on low back pain and neck pain: a systematic review.

PubMed

Driessen, Maurice T; Proper, Karin I; van Tulder, Maurits W; Anema, Johannes R; Bongers, Paulien M; van der Beek, Allard J

2010-04-01

Ergonomic interventions (physical and organisational) are used to prevent or reduce low back pain (LBP) and neck pain among workers. We conducted a systematic review of randomised controlled trials (RCTs) on the effectiveness of ergonomic interventions. A total of 10 RCTs met the inclusion criteria. There was low to moderate quality evidence that physical and organisational ergonomic interventions were not more effective than no ergonomic intervention on short and long term LBP and neck pain incidence/prevalence, and short and long term LBP intensity. There was low quality evidence that a physical ergonomic intervention was significantly more effective for reducing neck pain intensity in the short term (ie, curved or flat seat pan chair) and the long term (ie, arm board) than no ergonomic intervention. The limited number of RCTs included make it difficult to answer our broad research question and the results should be interpreted with care. This review, however, provides a solid overview of the high quality epidemiological evidence on the (usually lack of) effectiveness of ergonomic interventions on LBP and neck pain.

The Species Delimitation Uncertainty Principle

PubMed Central

Adams, Byron J.

2001-01-01

If, as Einstein said, "it is the theory which decides what we can observe," then "the species problem" could be solved by simply improving our theoretical definition of what a species is. However, because delimiting species entails predicting the historical fate of evolutionary lineages, species appear to behave according to the Heisenberg Uncertainty Principle, which states that the most philosophically satisfying definitions of species are the least operational, and as species concepts are modified to become more operational they tend to lose their philosophical integrity. Can species be delimited operationally without losing their philosophical rigor? To mitigate the contingent properties of species that tend to make them difficult for us to delimit, I advocate a set of operations that takes into account the prospective nature of delimiting species. Given the fundamental role of species in studies of evolution and biodiversity, I also suggest that species delimitation proceed within the context of explicit hypothesis testing, like other scientific endeavors. The real challenge is not so much the inherent fallibility of predicting the future but rather adequately sampling and interpreting the evidence available to us in the present. PMID:19265874

Preliminary normative data on the BORB for children aged 3-8.

PubMed

Brunsdon, Ruth; Joy, Pamela; Patten, Erin; Burton, Karen

2018-05-09

The Birmingham Object Recognition Battery (BORB) is a theoretically based test battery that is used in adult cognitive neuropsychology in research and for clinical assessment. It allows a detailed analysis of underlying impairments in individuals with brain injury who have visual object recognition difficulties. The BORB's usefulness in pediatrics is supported by numerous research studies. However, there is no published normative data for children, making clinical use of the test difficult. The aim of this brief report is to publish some preliminary normative data in 70 children aged between 3 and 8 years to assist both researchers and clinicians with interpretation of test scores. Results indicate that children's performance on individual BORB subtests varies according to task demands and age. For some subtests there is improvement in performance with increasing age. However, very young children (age 3-4 years) perform at adult levels on some subtests, or alternatively on other subtests they perform at the level of chance. The current paper supports the need for pediatric data for the BORB due to large normal individual variation in performance and varying age-related performance on individual BORB subtests.

[Methodological approach to the use of artificial neural networks for predicting results in medicine].

PubMed

Trujillano, Javier; March, Jaume; Sorribas, Albert

2004-01-01

In clinical practice, there is an increasing interest in obtaining adequate models of prediction. Within the possible available alternatives, the artificial neural networks (ANN) are progressively more used. In this review we first introduce the ANN methodology, describing the most common type of ANN, the Multilayer Perceptron trained with backpropagation algorithm (MLP). Then we compare the MLP with the Logistic Regression (LR). Finally, we show a practical scheme to make an application based on ANN by means of an example with actual data. The main advantage of the RN is its capacity to incorporate nonlinear effects and interactions between the variables of the model without need to include them a priori. As greater disadvantages, they show a difficult interpretation of their parameters and large empiricism in their process of construction and training. ANN are useful for the computation of probabilities of a given outcome based on a set of predicting variables. Furthermore, in some cases, they obtain better results than LR. Both methodologies, ANN and LR, are complementary and they help us to obtain more valid models.

Arcjet space thrusters

NASA Astrophysics Data System (ADS)

Keefer, Dennis; Rhodes, Robert

1993-05-01

Electrically powered arc jets which produce thrust at high specific impulse could provide a substantial cost reduction for orbital transfer and station keeping missions. There is currently a limited understanding of the complex, nonlinear interactions in the plasma propellant which has hindered the development of high efficiency arc jet thrusters by making it difficult to predict the effect of design changes and to interpret experimental results. A computational model developed at the University of Tennessee Space Institute (UTSI) to study laser powered thrusters and radio frequency gas heaters has been adapted to provide a tool to help understand the physical processes in arc jet thrusters. The approach is to include in the model those physical and chemical processes which appear to be important, and then to evaluate our judgement by the comparison of numerical simulations with experimental data. The results of this study have been presented at four technical conferences. The details of the work accomplished in this project are covered in the individual papers included in the appendix of this report. We present a brief description of the model covering its most important features followed by a summary of the effort.

Two interacting current model of holographic Dirac fluid in graphene

NASA Astrophysics Data System (ADS)

Rogatko, Marek; Wysokinski, Karol I.

2018-02-01

The electrons in graphene for energies close to the Dirac point have been found to form strongly interacting fluid. Taking this fact into account we have extended previous work on the transport properties of graphene by taking into account possible interactions between the currents and adding the external magnetic field directed perpendicularly to the graphene sheet. The perpendicular magnetic field B severely modifies the transport parameters. In the present approach the quantization of the spectrum and formation of Landau levels is ignored. Gauge/gravity duality has been used in the probe limit. The dependence on the charge density of the Seebeck coefficient and thermoelectric parameters αi j nicely agree with recent experimental data for graphene. The holographic model allows for the interpretation of one of the fields representing the currents as resulting from the dark matter sector. For the studied geometry with electric field perpendicular to the thermal gradient the effect of the dark sector has been found to modify the transport parameters but mostly in a quantitative way only. This makes difficult the detection of this elusive component of the Universe by studying transport properties of graphene.

The assessment of creativity in creativity/psychopathology research - a systematic review.

PubMed

Thys, E; Sabbe, B; De Hert, M

2014-01-01

The possible link between creativity and psychopathology has been a long time focus of research up to the present day. However, this research is hampered by methodological problems, especially the definition and assessment of creativity. This makes interpretation and comparison of studies difficult and possibly accounts for the contradictory results of this research. In this systematic review of the literature, research articles in the field of creativity and psychopathology were searched for creativity assessment tools. The tools used in the collected articles are presented and discussed. The results indicate that a multitude of creativity assessment tools were used, that many studies only used one tool to assess creativity and that most of these tools were only used in a limited number of studies. A few assessment tools stand out by a more frequent use, also outside psychopathological research, and more solid psychometric properties. Most scales used to evaluate creativity have poor psychometric properties. The scattered methodology to assess creativity compromises the generalizability and validity of this research. The field should creatively develop new validated instruments.

Midwives׳ clinical reasoning during second stage labour: Report on an interpretive study.

PubMed

Jefford, Elaine; Fahy, Kathleen

2015-05-01

clinical reasoning was once thought to be the exclusive domain of medicine - setting it apart from 'non-scientific' occupations like midwifery. Poor assessment, clinical reasoning and decision-making skills are well known contributors to adverse outcomes in maternity care. Midwifery decision-making models share a common deficit: they are insufficiently detailed to guide reasoning processes for midwives in practice. For these reasons we wanted to explore if midwives actively engaged in clinical reasoning processes within their clinical practice and if so to what extent. The study was conducted using post structural, feminist methodology. to what extent do midwives engage in clinical reasoning processes when making decisions in the second stage labour? twenty-six practising midwives were interviewed. Feminist interpretive analysis was conducted by two researchers guided by the steps of a model of clinical reasoning process. Six narratives were excluded from analysis because they did not sufficiently address the research question. The midwives narratives were prepared via data reduction. A theoretically informed analysis and interpretation was conducted. using a feminist, interpretive approach we created a model of midwifery clinical reasoning grounded in the literature and consistent with the data. Thirteen of the 20 participant narratives demonstrate analytical clinical reasoning abilities but only nine completed the process and implemented the decision. Seven midwives used non-analytical decision-making without adequately checking against assessment data. over half of the participants demonstrated the ability to use clinical reasoning skills. Less than half of the midwives demonstrated clinical reasoning as their way of making decisions. The new model of Midwifery Clinical Reasoning includes 'intuition' as a valued way of knowing. Using intuition, however, should not replace clinical reasoning which promotes through decision-making can be made transparent and be consensually validated. Copyright © 2015 Elsevier Ltd. All rights reserved.

[Interpretative method as a synthesis of explicative, teleologic and analogic models].

PubMed

Yáñez Cortés, R

1980-06-01

To establish the basis of the interpretative method is congruous with finding a solid basis--epistemologically speaking--to the analytic theory. This basis would be the means to transform this theory into a real science with its necessary adecuation among method, act and object of knowledge. It is only from a scientific stand that the psychoanalytic theory will be able to face successfully the reductionisms that menace it, be it the biologist-naturalism with its explanations of the psychic phenomena by means of mechanisms and biologic models or be it the speculative ideologies with their nucleus of technical praxis which make it impossible for the social-factic sciences to become real sciences. We propose as interpretative method the union of two models: the teleologic one which makes possible the appearance of intelligible, contingent and variable explanations between an antecedent and a consequent on one side, and on the other, the analogic model with its two moments: the comparative and the symbolic one. These moments makes possible the comparison and the union between antecedent and consequent baring in mind the "natural" ambiguity of the subject-object in question. The principal objective of the method--as a regulative idea in the Kantian sense--would be the search of univocity as regards the choice of one and only one sense from all the possible senses that "explain" the motive relationship or motive-end relationship in order to make the interpretation scientific. This status of scientificity should obey the rules of explanation: that the interpretations be derived effectively from the presupposed theory, that they really explain what they claim to explain, that they are not contradictory or contrary in the same ontologic level. We postulate that the synthesis of the two mentioned models, the teleologic-explanative and the analogic one allows us to find a possibility to make clear the "dark" sense of the noun interpretation and in this way the factibility of speaking of an interpretative method that develops the real concrete object by producing the formal and abstract one--which for us is the behaviour of the subject--. In this way the interpretations come to be teleological explanations overdetermined by an analogical relationship. This means that they produce the formal and abstract object -the method--which is in itself an intelligible, continguent and variable relationship between an antecedent and a consequent permitting in this way the emergence of a symbolic comparison to explain the real concrete. The symbolic explanations and comparisons are strictly derived from the presupposed theory, the theoretical body of psychoanalysis.

An ERP analysis of recognition and categorization decisions in a prototype-distortion task.

PubMed

Tunney, Richard J; Fernie, Gordon; Astle, Duncan E

2010-04-12

Theories of categorization make different predictions about the underlying processes used to represent categories. Episodic theories suggest that categories are represented in memory by storing previously encountered exemplars in memory. Prototype theories suggest that categories are represented in the form of a prototype independently of memory. A number of studies that show dissociations between categorization and recognition are often cited as evidence for the prototype account. These dissociations have compared recognition judgements made to one set of items to categorization judgements to a different set of items making a clear interpretation difficult. Instead of using different stimuli for different tests this experiment compares the processes by which participants make decisions about category membership in a prototype-distortion task and with recognition decisions about the same set of stimuli by examining the Event Related Potentials (ERPs) associated with them. Sixty-three participants were asked to make categorization or recognition decisions about stimuli that either formed an artificial category or that were category non-members. We examined the ERP components associated with both kinds of decision for pre-exposed and control participants. In contrast to studies using different items we observed no behavioural differences between the two kinds of decision; participants were equally able to distinguish category members from non-members, regardless of whether they were performing a recognition or categorisation judgement. Interestingly, this did not interact with prior-exposure. However, the ERP data demonstrated that the early visual evoked response that discriminated category members from non-members was modulated by which judgement participants performed and whether they had been pre-exposed to category members. We conclude from this that any differences between categorization and recognition reflect differences in the information that participants focus on in the stimuli to make the judgements at test, rather than any differences in encoding or process.