Science.gov

Sample records for malle mandre mari

  1. Marie

    NASA Image and Video Library

    2003-02-03

    Marie Curie rover drives down the rear ramp during Operational Readiness Test ORT 4. NASA Pathfinder, a low-cost Discovery mission, is the first of a new fleet of spacecraft that are planned to explore Mars.

  2. It's a Mall, Mall, Mall, Mall World: Jobs in Shopping Malls.

    ERIC Educational Resources Information Center

    Green, Kathleen

    1996-01-01

    Provides information about a variety of nonsales jobs available in shopping malls: mall management, customer service, marketing, operations, security, maintenance, and administration. Includes information about educational requirements. (JOW)

  3. It's a Mall, Mall, Mall, Mall World: Jobs in Shopping Malls.

    ERIC Educational Resources Information Center

    Green, Kathleen

    1996-01-01

    Provides information about a variety of nonsales jobs available in shopping malls: mall management, customer service, marketing, operations, security, maintenance, and administration. Includes information about educational requirements. (JOW)

  4. Marie

    NASA Image and Video Library

    2003-02-03

    Marie Curie sits on the lander petal prior to deployment during the pre-launch Operations Readiness Test ORT 6. NASA Pathfinder, a low-cost Discovery mission, is the first of a new fleet of spacecraft that are planned to explore Mars.

  5. The Mall

    NASA Image and Video Library

    2016-10-27

    This archival image was released as part of a gallery comparing JPL's past and present, commemorating the 80th anniversary of NASA's Jet Propulsion Laboratory on Oct. 31, 2016. This photograph from 1971 shows the open-air gathering area at NASA's Jet Propulsion Laboratory known as "The Mall." It looks east towards the Applied Mechanics building (the blocky white building now numbered 157). The person in the foreground is Robert Steinbacher, the project scientist for the Mariner 9 mission to Mars. The concrete bridge crossing the ponds remains, even though the ponds have been removed. Many trees and another building, the Central Engineering Building (301), block the view to Building 157 now. http://photojournal.jpl.nasa.gov/catalog/PIA21125

  6. MALL: The Pedagogical Challenges

    ERIC Educational Resources Information Center

    Burston, Jack

    2014-01-01

    In this paper the development of mobile-assisted language learning (MALL) over the past 20 years is reviewed with a particular focus on the pedagogical challenges facing its exploitation. Following a consideration of the definition of mobile learning, the paper describes the dominant mobile technologies upon which MALL applications have been…

  7. MALL: The Pedagogical Challenges

    ERIC Educational Resources Information Center

    Burston, Jack

    2014-01-01

    In this paper the development of mobile-assisted language learning (MALL) over the past 20 years is reviewed with a particular focus on the pedagogical challenges facing its exploitation. Following a consideration of the definition of mobile learning, the paper describes the dominant mobile technologies upon which MALL applications have been…

  8. Strip malls, city trees, and community values

    Treesearch

    Kathleen L. Wolf

    2009-01-01

    Strip malls (also known as mini-malls) are a common urban land use, historically promoted by U.S. zoning practices that concentrate retail and commercial development in a narrow band along arterials and major streets. More recently, communities are redeveloping mini-mall zones, expanding landscape plantings as biotechnology, and attempting to create a sense of place....

  9. Functional Morphology at the Mall

    ERIC Educational Resources Information Center

    Hippensteel, Scott P.

    2012-01-01

    The primary decorative flooring tile in the Southpark Mall in Charlotte, North Carolina, is fossiliferous limestone that contains Jurassic ammonoids and belemnoids. Visible in these tiles are more than 500 ammonoids, many of which have been cross sectioned equatorially perpendicular to the plane of coiling. Upper-level undergraduate students from…

  10. Functional Morphology at the Mall

    ERIC Educational Resources Information Center

    Hippensteel, Scott P.

    2012-01-01

    The primary decorative flooring tile in the Southpark Mall in Charlotte, North Carolina, is fossiliferous limestone that contains Jurassic ammonoids and belemnoids. Visible in these tiles are more than 500 ammonoids, many of which have been cross sectioned equatorially perpendicular to the plane of coiling. Upper-level undergraduate students from…

  11. On call at the mall: a mixed methods study of U.S. medical malls.

    PubMed

    Uscher-Pines, Lori; Mehrotra, Ateev; Chari, Ramya

    2013-11-09

    The decline of the traditional U.S. shopping mall and a focus on more consumer- centered care have created an opportunity for "medical malls". Medical malls are defined as former retail spaces repurposed for healthcare tenants or mixed-use medical/retail facilities.We aimed to describe the current reach of healthcare services in U.S. malls, characterize the medical mall model and emerging trends, and assess the potential of these facilities to serve low-income populations. We used a mixed methods approach which included a comprehensive literature review, key informant interviews, and a descriptive analysis of the Directory of Major Malls, an online retail database. Six percent (n = 89) of large, enclosed shopping malls in the U.S. include at least one non-optometry or dental healthcare tenant. We identified a total of 28 medical malls across the U.S., the majority of which opened in the past five years and serve middle or high income populations. Stakeholders felt the key strengths of medical malls were more convenient access including public transportation, greater familiarity for patients, and "one stop shopping" for primary care and specialty services as well as retail needs. While medical malls currently account for a small fraction of malls in the US, they are a new model for healthcare with significant potential for growth.

  12. Ibn Battuta Mall: Edutaining the World?

    ERIC Educational Resources Information Center

    Lee, Chae Ho

    2010-01-01

    Nakheel, a Dubai World Company has created the world's largest themed mall based on the narrative of Ibn Battuta, a 14th century Muslim explorer whose world travels are well documented. The Ibn Battuta Mall is located in the city of Dubai in the United Arab Emirates and utilizes a communication strategy called edutainment: a neologistic…

  13. "They Put a Library in the Mall!"

    ERIC Educational Resources Information Center

    Johnston, James R.

    1996-01-01

    Describes the experiences of the Joliet Public Library Outlet (Illinois), which was opened in a mall. Highlights include rent, access to the library and increased patronage, criteria for deciding between enclosed and strip malls, other location considerations. funding, and marketing. (AEF)

  14. Ibn Battuta Mall: Edutaining the World?

    ERIC Educational Resources Information Center

    Lee, Chae Ho

    2010-01-01

    Nakheel, a Dubai World Company has created the world's largest themed mall based on the narrative of Ibn Battuta, a 14th century Muslim explorer whose world travels are well documented. The Ibn Battuta Mall is located in the city of Dubai in the United Arab Emirates and utilizes a communication strategy called edutainment: a neologistic…

  15. The Shopping Mall: A Teenager Hangout.

    ERIC Educational Resources Information Center

    Anthony, Kathryn H.

    1985-01-01

    Investigated teenagers' use of the shopping mall as a "hangout" through interviews with 51 adolescents using the mall, and 10 hours of behavioral observations. Results indicated that many teenagers visit the shopping center regularly to watch members of the opposite sex, play video games, see friends, shop, and people-watch. (Author/NRB)

  16. The Shopping Mall: A Teenager Hangout.

    ERIC Educational Resources Information Center

    Anthony, Kathryn H.

    1985-01-01

    Investigated teenagers' use of the shopping mall as a "hangout" through interviews with 51 adolescents using the mall, and 10 hours of behavioral observations. Results indicated that many teenagers visit the shopping center regularly to watch members of the opposite sex, play video games, see friends, shop, and people-watch. (Author/NRB)

  17. Ivy-Covered Malls and Creeping Commercialism

    ERIC Educational Resources Information Center

    Molnar, Alex

    2005-01-01

    The Simon Property Group, United States' largest mall developer, since 1998 has partnered with local public school systems to open 19 alternative public schools in malls in 11 states through its nonprofit Simon Youth Foundation. Lafayette Square's school, with a 200-student capacity is the newest and largest, which according to a watchdog group,…

  18. On call at the mall: a mixed methods study of U.S. medical malls

    PubMed Central

    2013-01-01

    Background The decline of the traditional U.S. shopping mall and a focus on more consumer- centered care have created an opportunity for “medical malls”. Medical malls are defined as former retail spaces repurposed for healthcare tenants or mixed-use medical/retail facilities. We aimed to describe the current reach of healthcare services in U.S. malls, characterize the medical mall model and emerging trends, and assess the potential of these facilities to serve low-income populations. Methods We used a mixed methods approach which included a comprehensive literature review, key informant interviews, and a descriptive analysis of the Directory of Major Malls, an online retail database. Results Six percent (n = 89) of large, enclosed shopping malls in the U.S. include at least one non-optometry or dental healthcare tenant. We identified a total of 28 medical malls across the U.S., the majority of which opened in the past five years and serve middle or high income populations. Stakeholders felt the key strengths of medical malls were more convenient access including public transportation, greater familiarity for patients, and “one stop shopping” for primary care and specialty services as well as retail needs. Conclusions While medical malls currently account for a small fraction of malls in the US, they are a new model for healthcare with significant potential for growth. PMID:24209495

  19. 3. AERIAL VIEW OF THE MALL BETWEEN TWELFTH STREET AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. AERIAL VIEW OF THE MALL BETWEEN TWELFTH STREET AND THE WASHINGTON MONUMENT, LOOKING NORTH UP THE 14TH STREET AXIS FROM OVER THE WASHINGTON CHANNEL. - National Mall & Monument Grounds, Washington, District of Columbia, DC

  20. Same Time Same Place: Do MALL Classrooms Exist?

    ERIC Educational Resources Information Center

    Byrne, Jason

    2016-01-01

    This paper seeks to help clarify whether Mobile-Assisted Language Learning (MALL) is primarily an independent self-study activity or whether MALL classrooms exist. The research hypothesised that a large number of users frequently using specific MALL apps, at the same time and in the same city location, may indicate the existence of MALL…

  1. Analysis of Jingdong Mall Logistics Distribution Model

    NASA Astrophysics Data System (ADS)

    Shao, Kang; Cheng, Feng

    In recent years, the development of electronic commerce in our country to speed up the pace. The role of logistics has been highlighted, more and more electronic commerce enterprise are beginning to realize the importance of logistics in the success or failure of the enterprise. In this paper, the author take Jingdong Mall for example, performing a SWOT analysis of their current situation of self-built logistics system, find out the problems existing in the current Jingdong Mall logistics distribution and give appropriate recommendations.

  2. Distinguishing a University from a Shopping Mall.

    ERIC Educational Resources Information Center

    Moses, Daniel Noah

    2000-01-01

    Describes changes and program cuts at the University of Rochester as an illustration of a university being invaded by the corporate ethos, with the result that the school resembles an airport mall more than an institution of learning and community. Asserts that academics have a particular role to play in creating alternatives to a homogenizing…

  3. Mall Walking Program Environments, Features, and Participants: A Scoping Review.

    PubMed

    Farren, Laura; Belza, Basia; Allen, Peg; Brolliar, Sarah; Brown, David R; Cormier, Marc L; Janicek, Sarah; Jones, Dina L; King, Diane K; Marquez, David X; Rosenberg, Dori E

    2015-08-13

    Walking is a preferred and recommended physical activity for middle-aged and older adults, but many barriers exist, including concerns about safety (ie, personal security), falling, and inclement weather. Mall walking programs may overcome these barriers. The purpose of this study was to summarize the evidence on the health-related value of mall walking and mall walking programs. We conducted a scoping review of the literature to determine the features, environments, and benefits of mall walking programs using the RE-AIM framework (reach, effectiveness, adoption, implementation, and maintenance). The inclusion criteria were articles that involved adults aged 45 years or older who walked in indoor or outdoor shopping malls. Exclusion criteria were articles that used malls as laboratory settings or focused on the mechanics of walking. We included published research studies, dissertations, theses, conference abstracts, syntheses, nonresearch articles, theoretical papers, editorials, reports, policy briefs, standards and guidelines, and nonresearch conference abstracts and proposals. Websites and articles written in a language other than English were excluded. We located 254 articles on mall walking; 32 articles met our inclusion criteria. We found that malls provided safe, accessible, and affordable exercise environments for middle-aged and older adults. Programmatic features such as program leaders, blood pressure checks, and warm-up exercises facilitated participation. Individual benefits of mall walking programs included improvements in physical, social, and emotional well-being. Limited transportation to the mall was a barrier to participation. We found the potential for mall walking programs to be implemented in various communities as a health promotion measure. However, the research on mall walking programs is limited and has weak study designs. More rigorous research is needed to define best practices for mall walking programs' reach, effectiveness, adoption

  4. Mall Walking Program Environments, Features, and Participants: A Scoping Review

    PubMed Central

    Belza, Basia; Allen, Peg; Brolliar, Sarah; Brown, David R.; Cormier, Marc L.; Janicek, Sarah; Jones, Dina L.; King, Diane K.; Marquez, David X.; Rosenberg, Dori E.

    2015-01-01

    Introduction Walking is a preferred and recommended physical activity for middle-aged and older adults, but many barriers exist, including concerns about safety (ie, personal security), falling, and inclement weather. Mall walking programs may overcome these barriers. The purpose of this study was to summarize the evidence on the health-related value of mall walking and mall walking programs. Methods We conducted a scoping review of the literature to determine the features, environments, and benefits of mall walking programs using the RE-AIM framework (reach, effectiveness, adoption, implementation, and maintenance). The inclusion criteria were articles that involved adults aged 45 years or older who walked in indoor or outdoor shopping malls. Exclusion criteria were articles that used malls as laboratory settings or focused on the mechanics of walking. We included published research studies, dissertations, theses, conference abstracts, syntheses, nonresearch articles, theoretical papers, editorials, reports, policy briefs, standards and guidelines, and nonresearch conference abstracts and proposals. Websites and articles written in a language other than English were excluded. Results We located 254 articles on mall walking; 32 articles met our inclusion criteria. We found that malls provided safe, accessible, and affordable exercise environments for middle-aged and older adults. Programmatic features such as program leaders, blood pressure checks, and warm-up exercises facilitated participation. Individual benefits of mall walking programs included improvements in physical, social, and emotional well-being. Limited transportation to the mall was a barrier to participation. Conclusion We found the potential for mall walking programs to be implemented in various communities as a health promotion measure. However, the research on mall walking programs is limited and has weak study designs. More rigorous research is needed to define best practices for mall walking

  5. "Lost in a shopping mall" -- a breach of professional ethics.

    PubMed

    Crook, Lynn S; Dean, Martha C

    1999-01-01

    The "lost in a shopping mall" study has been cited to support claims that psychotherapists can implant memories of false autobiographical information of childhood trauma in their patients. The mall study originated in 1991 as 5 pilot experiments involving 3 children and 2 adult participants. The University of Washington Human Subjects Committee granted approval for the mall study on August 10, 1992. The preliminary results with the 5 pilot subjects were announced 4 days laters. An analysis of the mall study shows that beyond the external misrepresentions, internal scientific methodological errors cast doubt on the validity of the claims that have been attributed to the mall study within scholarly and legal arenas. The minimal involvement -- or, in some cases, negative impact -- of collegial consultation, acadmic supervision, and peer review throughout the evolution of the mall study are reviewed.

  6. The Shopping Mall: Film Chronotope of the 1980s.

    ERIC Educational Resources Information Center

    Montgomery, Michael V.

    This paper examines the portrayal of shopping malls in the films of the 1980s and attempts to "narrativize" the trend found between the films as the story of a subculture as it adopts and develops a belief system based on consumerism. The paper begins with an exploration of the evolution of the mall as a modern meeting place and center…

  7. Rats and Bunnies: Core Kids in an American Mall.

    ERIC Educational Resources Information Center

    Lewis, George H.

    1989-01-01

    Extensively interviewed over a six-week period regular, day-to-day adolescent frequenters (N=23) at a shopping mall. Found that subjects exhibited good deal of alienation from both family and school and used the mall as neutral ground on which to create fragile but mutually supportive community of kind. (Author/NB)

  8. A New Look for the Shopping Mall

    NASA Technical Reports Server (NTRS)

    1985-01-01

    STRUCTO-FAB, a product of Owens-Corning Fiberglas Corporation, is a lightweight but extremely durable tent-like material made of Fiberglas coated with Teflon. It transmits daylight with a reduced need for artificial lighting. It is an outgrowth of a material formulated by NASA in 1967 as a new space suit fabric. Owens-Corning and DuPont provided the original material, which was the basis for Structo-Fab, a permanent architectural fabric used for shopping malls, sports stadiums, etc.

  9. Astronomy Festival on the National Mall

    NASA Astrophysics Data System (ADS)

    Lubowich, D.

    2015-11-01

    The annual Astronomy Festival on the National Mall (AFNM) takes place on 11 acres north of the Washington Monument in June (previous AFNM were April and July). AFNM, sponsored by Hofstra University, features optical and radio telescope viewing of the Sun, Moon, planets, stars, clusters, and nebulae; a live large-screen image, a cell phone imaging mount; exhibits; hands-on activities; videos; large outdoor banners and posters; citizen science activities; hand-outs; bookmarks, and teacher information materials. With no tall buildings almost the entire sky is visible and 10th mag. moons of Saturn and the Ring Nebula (9.75 mag.) were easily visible on clear nights. Representatives from some of the nation's foremost scientific and educational institutions presented exciting demonstrations and activities; and answered questions about careers in science, celestial objects, and the latest astronomical discoveries. Local amateur astronomers set up twenty telescopes on the Mall and long lines of 20-30 people waited to look through the telescopes. Visitors met astronaut Dr. John Grunsfeld (Associate Administrator, NASA) and astronomers Dr. Lisse, Dr. Livengood, Dr. Warren, and Dr. Paul Hertz (Director, Astrophysics Division, NASA). Important historical astronomers spoke to the attendees: Caroline Herschel (Lynn King); Tycho Brahe (Dean Howarth); and Johannes Kepler (Jeff Jones). Free telescopes, donated by Celestron, were raffled off.

  10. 75 FR 1406 - National Mall and Memorial Parks, Washington, DC; Notice of Availability of an Environmental...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-11

    ... National Park Service National Mall and Memorial Parks, Washington, DC; Notice of Availability of an... Mall Plan, within the National Mall and Memorial Parks in Washington, DC. The National Mall Plan is a..., SW., Washington, DC 20024, and at local libraries around Washington, DC. SUPPLEMENTARY...

  11. Lost in the mall: misrepresentations and misunderstandings.

    PubMed

    Loftus, Elizabeth F

    1999-01-01

    Readers of Ethics and Behavior have been treated to a misrepresentation of my research on planting false memories, to a misstatement of the actual empirical finidngs, and to a distortion of the history of the development of the idea for this line of research. The partisan essay by Crook and Dean which appears in this issue ("'Lost in a Shopping Mall' -- A Breach of Professional Ethics") is disturbing not only because of its errors, exaggerations, and omissions, but because, in some instances, the quality of the argument makes one wonder whether these were innocent mistakes or a deliberate attempt to distort my work. Some of these errors can be explained by simple lack of scientific competence. However, others are sufficiently bizarre that they cast doubt on the process that led to the acceptance of a manuscript written by an individual who has continually made her animosity toward me very publicly known (e.g., Boerner, 1996; Neimark, 1996).

  12. 4. INTERIOR VIEW, WATERSIDE MALL Southwest Washington, Urban Renewal ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. INTERIOR VIEW, WATERSIDE MALL - Southwest Washington, Urban Renewal Area, Bounded by Independence Avenue, Washington Avenue, South Capitol Street, Canal Street, P Street, Maine Avenue & Washington Channel, Fourteenth Street, D Street, & Twelfth Street, Washington, District of Columbia, DC

  13. 38. STAIRS FROM ENTRANCE AT SIXTEENTH STREET TO UPPER MALL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    38. STAIRS FROM ENTRANCE AT SIXTEENTH STREET TO UPPER MALL PARK, LOOKING SOUTH, summer 1985 - Meridian Hill Park, Bounded by Fifteenth, Sixteenth, Euclid & W Streets, Northwest, Washington, District of Columbia, DC

  14. 37. STAIRS TO ENTRANCE AT SIXTEENTH STREET FROM UPPER MALL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    37. STAIRS TO ENTRANCE AT SIXTEENTH STREET FROM UPPER MALL PARK, LOOKING NORTH, August 1976 - Meridian Hill Park, Bounded by Fifteenth, Sixteenth, Euclid & W Streets, Northwest, Washington, District of Columbia, DC

  15. Context, view to north from mall; from left to right, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Context, view to north from mall; from left to right, flight markers, camp buildings, and visitor center - Wright Brothers National Memorial Visitor Center, Highway 158, Kill Devil Hills, Dare County, NC

  16. Indoor air quality at nine shopping malls in Hong Kong.

    PubMed

    Li, W M; Lee, S C; Chan, L Y

    2001-06-12

    Hong Kong is one of the most attractive shopping paradises in the world. Many local people and international tourists favor to spend their time in shopping malls in Hong Kong. Good indoor air quality is, therefore, very essential to shoppers. In order to characterize the indoor air quality in shopping malls, nine shopping malls in Hong Kong were selected for this study. The indoor air pollutants included carbon dioxide (CO2), carbon monoxide (CO), total hydrocarbons (THC), formaldehyde (HCHO), respirable particulate matter (PM10) and total bacteria count (TBC). More than 40% of the shopping malls had 1-h average CO2 levels above the 1000 ppm of the ASHRAE standard on both weekdays and weekends. Also, they had average weekday PM10 concentrations that exceeded the Hong Kong Indoor Air Quality Objective (HKIAQO). The highest indoor PM10 level at a mall was 380 microg/m3. Of the malls surveyed, 30% had indoor airborne bacteria levels above 1000 cfu/m3 set by the HKIAQO. The elevated indoor CO2 and bacteria levels could result from high occupancy combined with insufficient ventilation. The increased PM10 levels could be probably attributed to illegal smoking inside these establishments. In comparison, the shopping malls that contained internal public transport drop-off areas, where vehicles were parked with idling engines and had major entry doors close to heavy traffic roads had higher CO and PM10 indoor levels. In addition, the extensive use of cooking stoves without adequate ventilation inside food courts could increase indoor CO2, CO and PM10 levels.

  17. Pulling Mobile Assisted Language Learning (MALL) into the Mainstream: MALL in Broad Practice

    PubMed Central

    Wu, Qun

    2015-01-01

    The researcher designed a smartphone app to help college students to learn English (L2) vocabulary. The app contained 3,402 English words that were compiled into an alphabetic wordlist with each word displayed on three features; namely: spelling, pronunciation and Chinese definitions. To test the effectiveness of the app, an experimental group (with app) was compared with a control group (without app) and knowledge of words was tested before and after the research. The study revealed that the students using the program significantly outperformed those in the control group in vocabulary acquisition. This paper introduced a research design method and set up a pedagogical paradigm which can be followed as a way to practice MALL. PMID:26010606

  18. Pulling Mobile Assisted Language Learning (MALL) into the Mainstream: MALL in Broad Practice.

    PubMed

    Wu, Qun

    2015-01-01

    The researcher designed a smartphone app to help college students to learn English (L2) vocabulary. The app contained 3,402 English words that were compiled into an alphabetic wordlist with each word displayed on three features; namely: spelling, pronunciation and Chinese definitions. To test the effectiveness of the app, an experimental group (with app) was compared with a control group (without app) and knowledge of words was tested before and after the research. The study revealed that the students using the program significantly outperformed those in the control group in vocabulary acquisition. This paper introduced a research design method and set up a pedagogical paradigm which can be followed as a way to practice MALL.

  19. Jean-Marie Straub.

    ERIC Educational Resources Information Center

    Roud, Richard

    This book covers the life and aesthetic qualities of the work of the European film-maker Jean-Marie Straub (1933- ). It contains introductory chapters on the biography and artistic milieu of Straub and continues with a chapter-by-chapter critical treatment of each of his films: "Machorka-Muff"; "Not Reconciled"; "Chronicle…

  20. Jean-Marie Straub.

    ERIC Educational Resources Information Center

    Roud, Richard

    This book covers the life and aesthetic qualities of the work of the European film-maker Jean-Marie Straub (1933- ). It contains introductory chapters on the biography and artistic milieu of Straub and continues with a chapter-by-chapter critical treatment of each of his films: "Machorka-Muff"; "Not Reconciled"; "Chronicle…

  1. MARI mini-manual

    NASA Astrophysics Data System (ADS)

    Bennington, S. M.; Eccleston, R. S.

    1994-09-01

    The MARI spectrometer is funded by the Japanese Ministry of Education, Culture and Science (Monbusho) as part of the UK-Japan collaboration in neutron scattering. MARI is a direct geometry chopper spectrometer. It uses a Fermi chopper to monochromatic the incident neutron beam to give incident energies in the range 10 to 2000 meV. It is very similar in design to its sister machine HET, but with a detector bank that continuously covers the angular range from 3 to 135 degrees, MARI is able to map large regions of Q-E space in a single measurement. At present about 600 of the full complement of 1000 detectors are installed. All are 10 bar (3)He gas proportional counters and all come from the same manufacturer, this means that their efficiency and background are almost the same. The beam size at the sample position is 50 by 50 mm, but motorized jaws in the Fermi chopper pit and in the sample tank can be used to reduce this size. Chapter headings are the following: Introduction; The hardware on MARI; Controlling the Instrument; Data Analysis and Visualization; Appendices.

  2. Virtual Learning Environments on the Go: CALL Meets MALL

    ERIC Educational Resources Information Center

    Arús Hita, Jorge

    2016-01-01

    This paper presents "Eating out," a Moodle-based digital learning resource for English as a Foreign Language (EFL) teaching that can be run both on computers and mobile devices. It is argued that Mobile Assisted Language Learning (MALL) resources do not necessarily need to be specifically designed for such platforms. Rather, a carefully…

  3. 3. VIEW OF WATERSIDE MALL SHOPPING CENTER (M STREET SIDE) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. VIEW OF WATERSIDE MALL SHOPPING CENTER (M STREET SIDE) DESIGNED BY CHLOETHIEL WOODARD SMITH & ASSOCIATES AND BUILT IN 1972 - Southwest Washington, Urban Renewal Area, Bounded by Independence Avenue, Washington Avenue, South Capitol Street, Canal Street, P Street, Maine Avenue & Washington Channel, Fourteenth Street, D Street, & Twelfth Street, Washington, District of Columbia, DC

  4. 5. VIEW OF THE REAR OF WATERSIDE MALL Southwest ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. VIEW OF THE REAR OF WATERSIDE MALL - Southwest Washington, Urban Renewal Area, Bounded by Independence Avenue, Washington Avenue, South Capitol Street, Canal Street, P Street, Maine Avenue & Washington Channel, Fourteenth Street, D Street, & Twelfth Street, Washington, District of Columbia, DC

  5. 12. CLOSER VIEW ALONG TENTH STREET MALL LOOKING TO FORRESTAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. CLOSER VIEW ALONG TENTH STREET MALL LOOKING TO FORRESTAL BUILDING - Southwest Washington, Urban Renewal Area, Bounded by Independence Avenue, Washington Avenue, South Capitol Street, Canal Street, P Street, Maine Avenue & Washington Channel, Fourteenth Street, D Street, & Twelfth Street, Washington, District of Columbia, DC

  6. Adolescents and Adults at the Mall: Dyadic Interactions.

    ERIC Educational Resources Information Center

    Readdick, Christine A.; Mullis, Ronald L.

    1997-01-01

    Examines differences in interpersonal engagements between teen-teen dyads (n=865) and teen-adults dyads (n=190) in a mall. Results indicate that teen-teen dyads differed from teen-adult dyads on two variables: conversation and shopping evidence. Within teen-teen dyad comparisons yielded gender and racial differences, but only one age difference.…

  7. Let's Go to the Mall: Thinking outside the Neighborhood Branch, Libraries in Malls Make for Happy Partnerships and Patrons

    ERIC Educational Resources Information Center

    Blankinship, Donna Gordon

    2005-01-01

    Branches in shopping malls help build community by attracting new patrons to the library. They help libraries offer exciting new venues with a retail-like approach and raise awareness of the work libraries are doing. In some cases, though not at Glendale, the library is more cost-effective owing to the smaller space used to serve patrons. These…

  8. Return to Flight activities at The Mall at Cortana

    NASA Technical Reports Server (NTRS)

    2005-01-01

    Christian Gonzales, 11 (right), watches as his little brother Walter, 2, adds his own brand of good wishes to a banner encouraging the crew of Space Shuttle Discovery on NASA's Return to Flight mission, scheduled to launch in summer 2005. The brothers, of Baton Rouge, were participating in a Camp Kids event at The Mall at Cortana, where Return to Flight activities were presented by NASA's Stennis Space Center (SSC).

  9. Return to Flight activities at The Mall at Cortana

    NASA Image and Video Library

    2005-06-28

    Christian Gonzales, 11 (right), watches as his little brother Walter, 2, adds his own brand of good wishes to a banner encouraging the crew of Space Shuttle Discovery on NASA's Return to Flight mission, scheduled to launch in summer 2005. The brothers, of Baton Rouge, were participating in a Camp Kids event at The Mall at Cortana, where Return to Flight activities were presented by NASA's Stennis Space Center (SSC).

  10. Area contingency plan Sault Ste. Marie. (COTP Sault Ste. Marie)

    SciTech Connect

    1995-06-01

    The Area Contingency Plan, mandated under the Oil Pollution Act, was developed by Sault Ste. Marie Area Committee, which is chaired by the U.S. Coast Guard and consists of local, state, federal, and private members. The plan prepares in advance for an oil or hazardous substance spill in the CTOP Sault Ste. Marie Coastal Zone.

  11. Environmental Assessment: Proposed Construction of Army and Air Force Exchange Service Mini-Mall

    DTIC Science & Technology

    2003-10-01

    fast food style restaurant would be accommodated in the mini- mall . Data on electrical consumption for the Burger King restaurant at MAFB (Building...proposed action, a new fast food restaurant would be accommodated in the mini- mall . Data on water consumption for the Burger King restaurant at MAFB...treatment plant in FY 2001. Under the proposed action, a new fast food restaurant would be accommodated in the mini- mall . The Burger King restaurant

  12. Rehabilitation in the real-life environment of a shopping mall.

    PubMed

    Labbé, Delphine; Poldma, Tiiu; Fichten, Catherine; Havel, Alice; Kehayia, Eva; Mazer, Barbara; McKinley, Patricia; Rochette, Annie; Swaine, Bonnie

    2017-01-27

    The aim of this study was to explore how shopping malls could be used during rehabilitation and to identify the facilitators and barriers to their use. Two focus groups, conducted with 15 rehabilitation professionals from various disciplines and working with people with disabilities of all ages were structured around two topics: (i) The usage of malls for rehabilitation and (ii) Factors that facilitate or limit rehabilitation professionals' use of the mall as an environment for clinical assessment and/or intervention. The thematic analysis revealed that shopping malls were used to achieve several rehabilitation goals targeting physical and cognitive skills, psychological health and socialization. This real-life environment is motivating and helps foster independence and normalization. Factors affecting mall use during rehabilitation included personal factors (e.g. clients' personality and level of readiness) and environmental factors (e.g. clinical context, accessibility of the mall and social attitudes of store owners). Shopping malls may be a relevant rehabilitation assessment and treatment environment that could contribute to optimizing community integration of people with disabilities. Implications for rehabilitation To ensure successful community reintegration, clients could be trained at some point during their rehabilitation, to perform activities in real-life settings, such as a shopping mall. Shopping malls appear to enable the attainment of rehabilitation goals targeting a variety of skills. This real-life environment appears to be motivating and helps foster independence and normalization. Factors felt to affect mall use during rehabilitation include personal factors (e.g. clients' personality and level of readiness) and environmental factors (e.g. clinical context, accessibility of the mall and social attitudes of store owners). The shopping mall may be an untapped resource as it appears to be a relevant rehabilitation assessment and treatment

  13. Vancouver shopping mall liable for discrimination against Aboriginal and disabled people.

    PubMed

    Betteridge, Glenn

    2005-12-01

    In a decision released on 13 July 2005, the British Columbia Human Rights Tribunal (the Tribunal) found that the owners of a mall and the security company contracted by the mall had engaged in both individual and systemic discrimination. Among other findings, the Tribunal determined that Henderson Development (Canada) Limited (Henderson) and Securiguard Services Limited (Securiguard) discriminated against mall patrons who were Aboriginal, or who were perceived to be living with a disability, including drug dependence and HIV/AIDS.

  14. Discrimination against teenagers in the mall environment: a case from Ankara, Turkey.

    PubMed

    Mugan, Guliz; Erkip, Feyzan

    2009-01-01

    Teenagers spend much of their leisure time at shopping malls which is a result of factors such as parental constraints due to the incivility of the streets, financial dependence, and limited financial resources. Migros, a shopping mall in Ankara was chosen as the site for this research with the main purpose of studying discrimination patterns against teenagers in the mall environment. The research was carried out through observation and in-depth interviews with 104 teenagers. Results indicate that, although they have some complaints, most of the teenagers do not perceive discrimination in the mall, unlike their foreign counterparts.

  15. Mary, dogma, and psychoanalysis.

    PubMed

    Todd, E H

    1985-06-01

    Why does Mary hold her prominent place in Catholic theology to the extent that five specific dogmas have developed around her? Psychoanalytic theory suggests dogma arises out of the psychic needs of people and psychic needs of people are expressed in dogma. The early views of Erich Fromm, a disciple of Freud, are presented to demonstrate that Marian dogma arose from the psychic needs of the people. The views of both Catholic and Protestant thinkers are presented, as well as theological and psychiatric views.

  16. AN ELECTRICAL HAIL MARY.

    PubMed

    Neubert, David

    2016-05-01

    Double sequential defibrillation is currently being employed in a number of EMS systems across the United States, including Wake County, N.C.; Fort Worth, Texas; and New Orleans. Even though there isn't a large body of literature surrounding this technique, it's been demonstrated successful in the electrophysiology lab, ED and prehospital settings. Since access to procainamide--another treatment for refractory v fib--is limited, this may be the only available option when faced with a patient who's failed standard ACLS defibrillation and medication administration. It's an intervention that has little chance to do harm, and it may represent the "hail Mary" pass to a successful ROSC touchdown.

  17. Exploring the Application of a Conceptual Framework in a Social MALL App

    ERIC Educational Resources Information Center

    Read, Timothy; Bárcena, Elena; Kukulska-Hulme, Agnes

    2016-01-01

    This article presents a prototype social Mobile Assisted Language Learning (henceforth, MALL) app based on Kukulska-Hulme's (2012) conceptual framework. This research allows the exploration of time, place and activity type as key factors in the design of MALL apps, and is the first step toward a systematic analysis of such a framework in this type…

  18. A Survey of MALL Curriculum Integration: What the Published Research Doesn't Tell

    ERIC Educational Resources Information Center

    Burston, Jack

    2014-01-01

    Despite the large number of published articles dealing with Mobile-Assisted Language Learning (MALL) applications over the past two decades, very few relate to the curricular integration of mobile technologies beyond initial projects. This situation raises a primary research question as to whether or not MALL implementation publications reflect…

  19. Community context and strip mall retail: public response to the roadside landscape

    Treesearch

    Kathleen. Wolf

    2008-01-01

    Strip malls (or mini-malls) are a common land use, historically promoted by U.S. zoning practices that concentrate retail and commercial development in a narrow band along urban arterials and major streets. They are an entry-level retail niche offering opportunity for independent, start-up businesses that serve a limited market....

  20. Going to the Mall: A Leisure Activity of Urban Elderly People.

    ERIC Educational Resources Information Center

    Graham, Dawn Fowler; And Others

    1991-01-01

    Telephone interviews with 300 elderly Montreal residents found that 67 percent use shopping malls to fulfill social and leisure needs. Predisposing variables (age, gender, education, and loneliness) and environmental/encouraging variables (design and ambiance of the malls) were found to be related to this activity. (SK)

  1. 76 FR 66960 - Record of Decision on the Final Environmental Impact Statement for the National Mall Plan...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-28

    ... Plan, National Mall and Memorial Parks, Washington, DC AGENCY: National Park Service, Interior. ACTION... Mall Plan, National Mall and Memorial Parks, Washington, DC. SUMMARY: Pursuant to the National... Memorial Parks, 900 Ohio Drive SW., Washington, DC 20024-2000. Copies are also posted online at...

  2. MALL liposuction: the natural evolution of subdermal superficial liposuction.

    PubMed

    Gasperoni, C; Salgarello, M

    1994-01-01

    Subdermal superficial liposuction, first presented by the authors at the ISAPS Congress at Zurich in 1989, is performed with thin three-hole Mercedes cannulas (diameter ranges from 1.8 to 2 mm) to treat small and secondary adiposities and to allow better skin retraction. Suction of the subdermal layer of fat reduces the thickness and consistency of the superficial fat and enhances the possibility of skin retraction. In cases where there is a large adiposity of the abdomen, arms, or inner thighs, there is a conspicuous volume of fat whose weight tends to overstretch and to carry the overlying skin downward. In these cases we need to reduce the large fat volume to permit effective skin retraction. Therefore, we apply the principles of traditional liposuction with those of subdermal superficial liposuction to aspirate large amounts of fat from all the adipose layers. We call this technique Massive All Layer Liposuction (MALL). The amount of skin shrinkage after this "defatting" procedure is remarkable and the clinical results are very good. The MALL technique can be applied to other areas as well. In our experience this new liposuction technique has dramatically reduced the indications of abdominoplasties and dermolipectomies of inner thighs and arms.

  3. Mary Shelley: Teaching and Learning through "Frankenstein"

    ERIC Educational Resources Information Center

    Girard, Theresa M.

    2009-01-01

    In the writing of "Frankenstein", Mary Shelley was able to change the course of women's learning, forever. Her life started from an elite standpoint as the child of Mary Wollstonecraft and William Godwin. As such, she was destined to grow to be a major influence in the world. Mary Shelley's formative years were spent with her father and his many…

  4. Teens: Want a Brighter Smile? Visit the Dentist, Not the Shopping Mall

    MedlinePlus

    ... Looking for a Better Job? Start by Visiting the Dentist Long ago, most men worked for one ... desktop! more... Teens: Want a Brighter Smile? Visit the Dentist, not the Shopping Mall Article Chapters Teens: ...

  5. Adolescents with disabilities participate in the shopping mall: facilitators and barriers framed according to the ICF.

    PubMed

    Dahan-Oliel, Noémi; Shikako-Thomas, Keiko; Mazer, Barbara; Majnemer, Annette

    2016-10-01

    Community participation is restricted for youth with disabilities. The mall is an important gathering place where adolescents often socialise and develop community living skills, yet participation may be restricted. The aim of this study was to evaluate the facilitators and barriers to participation in a shopping mall through the perspectives of adolescents with disabilities. Semi-structured individual interviews were conducted with adolescents aged 12-19 years with a physical and/or sensory disability. Audio recordings were transcribed verbatim and coded following a template analysis using the International Classification of Functioning Disability and Health (ICF). Eleven youth (six females, mean age = 17.0 years) participated. Medical conditions included visual impairment, hearing impairment, cerebral palsy, hemiplegia, osteogenesis imperfecta and congenital amputations. Six themes were identified by the adolescents: what the shopping mall means to me, physical environment, transportation, social factors, attitudes and the person. The majority of themes mapped to the ICF's 'environmental factors'. Facilitators and barriers identified were either generic or disability-specific, implying that some modifications to shopping malls may be beneficial across disability types. Changes made to the physical, social and attitudinal environment are required to enable full participation of youth with disabilities within a shopping mall and other built environments of high public access. Implications for Rehabilitation The meaning of the shopping mall according to youth with disabilities includes socialisation, shopping, getting out of the home and employment. The majority of themes mapped to 'environmental factors' indicating that most obstacles to participation are caused by environmental barriers. Facilitators and barriers identified were either generic or disability-specific implying that some modifications to shopping malls may be beneficial across disability types

  6. Charcot-Marie-Tooth Disease

    MedlinePlus

    Charcot-Marie-Tooth disease (CMT) is a group of genetic nerve disorders. It is named after the three doctors who first identified it. ... a nerve biopsy. There is no cure. The disease can be so mild you don't realize ...

  7. The Displacement of Mary Jones.

    ERIC Educational Resources Information Center

    McCaslin, Sharon

    1990-01-01

    Describes the experiences of Mary Jones as librarian at the University of Nebraska (1892-97), her resignation attributed to sex discrimination, the impact of her resignation on the library, and her subsequent positions at the University of Illinois, University of Iowa, and Los Angeles Public Library. A sidebar discusses women's career paths in the…

  8. M-ary Laguerre detection.

    NASA Technical Reports Server (NTRS)

    Mohanty, N. C.

    1973-01-01

    In a communication system using optical devices, the receiver is modeled as a counter of electrons which are emitted from a photodetector when a modulated optical wave is incident on it. The synthesis of the optimal receiver processing and its resulting performance depend upon the statistics associated with this counting. In an M-ary system, the transmitter selects one of a set of M intensities for the optical process. Questions of error probability are investigated.

  9. Martian Radiation Environment Experiment (MARIE)

    NASA Astrophysics Data System (ADS)

    Lee, Kerry T.

    The radiation environment between Earth and Mars and particularly at Mars, must be known prior to sending astronauts on lengthy exploratory missions. In an effort to understand the radiation environment that future astronauts will be exposed to, the Martian Radiation Environment Experiment (MARIE) was sent to Mars aboard the 2001 Odyssey spacecraft. Odyssey left Earth April 7, 2001 and arrived at Mars on October 23, 2001. MARIE collected data from April 2001 - August 2001 and from March 2002 - October 2003. MARIE is capable of detecting charged nuclei with energies greater than 30 MeV/u, and elements can be distinguished for charges of Z < 11. The average dose at Mars is about twice that measured by instruments aboard the International Space Station. Although the radiation level at Mars is higher than that experienced in low-Earth orbit (LEO), the measured radiation level does not necessarily preclude a manned Mars mission. However, the measurement does conclude that proper shielding materials must be used in the habitation module of any spacecraft and a highly shielded area must be provided as shelter from intense solar particle events (SPE) in order to minimize the total radiation dose received by any exploration crew. The data presented here are the absolute flux measurements of protons and He in Mars orbit in the energy range of 50 - 240 MeV/u.

  10. Learning English Vocabulary in a Mobile Assisted Language Learning (MALL) Environment: A Sociocultural Study of Migrant Women

    ERIC Educational Resources Information Center

    Ahmad, Kham Sila; Sudweeks, Fay; Armarego, Jocelyn

    2015-01-01

    This paper reports on a case study of a group of six non-native English speaking migrant women's experiences learning English vocabulary in a mobile assisted language learning (MALL) environment at a small community centre in Western Australia. A sociocultural approach to learning vocabulary was adopted in designing the MALL lessons that the women…

  11. Learning English Vocabulary in a Mobile Assisted Language Learning (MALL) Environment: A Sociocultural Study of Migrant Women

    ERIC Educational Resources Information Center

    Ahmad, Kham Sila; Sudweeks, Fay; Armarego, Jocelyn

    2015-01-01

    This paper reports on a case study of a group of six non-native English speaking migrant women's experiences learning English vocabulary in a mobile assisted language learning (MALL) environment at a small community centre in Western Australia. A sociocultural approach to learning vocabulary was adopted in designing the MALL lessons that the women…

  12. Creating an inclusive mall environment with the PRECEDE-PROCEED model: a living lab case study.

    PubMed

    Ahmed, Sara; Swaine, Bonnie; Milot, Marc; Gaudet, Caroline; Poldma, Tiiu; Bartlett, Gillian; Mazer, Barbara; Le Dorze, Guylaine; Barbic, Skye; Rodriguez, Ana Maria; Lefebvre, Hélène; Archambault, Philippe; Kairy, Dahlia; Fung, Joyce; Labbé, Delphine; Lamontagne, Anouk; Kehayia, Eva

    2017-10-01

    Although public environments provide opportunities for participation and social inclusion, they are not always inclusive spaces and may not accommodate the wide diversity of people. The Rehabilitation Living Lab in the Mall is a unique, interdisciplinary, and multi-sectoral research project with an aim to transform a shopping complex in Montreal, Canada, into an inclusive environment optimizing the participation and social inclusion of all people. The PRECEDE-PROCEDE Model (PPM), a community-oriented and participatory planning model, was applied as a framework. The PPM is comprised of nine steps divided between planning, implementation, and evaluation. The PPM is well suited as a framework for the development of an inclusive mall. Its ecological approach considers the environment, as well as the social and individual factors relating to mall users' needs and expectations. Transforming a mall to be more inclusive is a complex process involving many stakeholders. The PPM allows the synthesis of several sources of information, as well as the identification and prioritization of key issues to address. The PPM also helps to frame and drive the implementation and evaluate the components of the project. This knowledge can help others interested in using the PPM to create similar enabling and inclusive environments world-wide. Implication for rehabilitation While public environments provide opportunities for participation and social inclusion, they are not always inclusive spaces and may not accommodate the wide diversity of people. The PRECEDE PROCEDE Model (PPM) is well suited as a framework for the development, implementation, and evaluation of an inclusive mall. Environmental barriers can negatively impact the rehabilitation process by impeding the restoration and augmentation of function. Removing barriers to social participation and independent living by improving inclusivity in the mall and other environments positively impacts the lives of people with disabilities.

  13. Food consumption and buying patterns of students from a Philippine university fastfood mall.

    PubMed

    Patricia, M; Azanza, V

    2001-11-01

    A consumer survey was conducted in a university fastfood mall to determine the food consumption and buying patterns of Philippine university students. The survey established that a typical fastfood consumer in the test university foodmall is female between 16 and 22 years old, with a purchasing capability of < or = US$1.79 for a complete meal, and who generally frequents the mall only once a day during weekdays. Wholesomeness, affordability and variety of the foods were the general basis for satisfaction of the typical student consumer.

  14. Nunaput Negeqlirmi (Our Village of St. Mary's).

    ERIC Educational Resources Information Center

    Alaska State Dept. of Education, Juneau.

    Yup'ik Eskimo children from the fifth and sixth grades of St. Mary's Public School, St. Mary's, Alaska, wrote this collection of 28 short stories. The 55 page book is printed in both Yup'ik and English. It features large type and illustrations drawn by the children and is intended for use in a bilingual education program. Some of the stories deal…

  15. Theresa Marie Schiavo's Long Road to Peace

    ERIC Educational Resources Information Center

    Cerminara, Kathy L.

    2006-01-01

    The death of Theresa Marie Schiavo came about only after almost 7 years of argument among her family members. Her husband, Michael Schiavo, was convinced that she would have refused the medically supplied nutrition and hydration maintaining her life. Her parents, Robert and Mary Schindler, and her siblings were equally convinced that her condition…

  16. Impact of Mobile Assisted Language Learning (MALL) on EFL: A Meta-Analysis

    ERIC Educational Resources Information Center

    Taj, Imtiaz Hassan; Sulan, Norrihan Binti; Sipra, Muhammad Aslam; Ahmad, Waqar

    2016-01-01

    Mobile Assisted Language Learning (MALL) has emerged as a potential tool in the instruction of English as a foreign language (EFL). Meta-analysis of 13 studies published between year 2008 and 2015 was conducted. Four point criteria for the selection of studies for analysis is based on the year of publication, quasi-experimental design, pretest and…

  17. Pedestrian Choice Behavior at Shopping Mall Intersections in China and the United States

    ERIC Educational Resources Information Center

    Bitgood, Stephen; Davey, Gareth; Huang, Xiaoyi; Fung, Holly

    2013-01-01

    Pedestrian navigation through public spaces reflects the nature of interaction between behavior and environment. This study compared pedestrian choice behavior at shopping mall intersections in China and the United States. The study found that in both countries (a) pedestrians chose movement patterns that involved the fewest steps and (b) there…

  18. Design and Implementation of BusinessApp, a MALL Application to Make Successful Business Presentations

    ERIC Educational Resources Information Center

    Calle-Martínez, Cristina; Yanes, Lourdes Pomposo; Pareja-Lora, Antonio

    2016-01-01

    Little by little, (or, simply, MALL) is taking force in the field of education, as it supports language blended learning and language learning ubiquity. The study presented here belongs in the Social Ontology-based Cognitively Augmented Language Learning Mobile Environment (SO-CALL-ME) research project, whose final aim is to design and create…

  19. A comparison of molecular mass determination of hyaluronic acid using SEC/MALLS and sedimentation equilibrium.

    PubMed

    Hokputsa, Sanya; Jumel, Kornelia; Alexander, Catherine; Harding, Stephen E

    2003-08-01

    Hyaluronic acid (HA) is a natural polysaccharide with importance in the pharmaceutical, medical and cosmetic industries. Determining factors in its final applications are its physicochemical properties, particularly molecular mass. A high molecular mass HA was degraded using five different hydroxyl free-radical starting concentrations chemically produced from ascorbic acid and hydrogen peroxide. The aims of the study were to investigate the effect of different hydroxyl free-radical concentrations on the chain length of HA and compare the molecular masses obtained from analytical ultracentrifugation using sedimentation equilibrium experiments and size exclusion chromatography/multi-angle laser light scattering (SEC/MALLS). The results indicated that their molecular masses varied, depending on the degree of hydroxyl free-radical starting concentration. Molecular mass values obtained from sedimentation equilibrium experiments for each sample showed the same trend as those obtained from the SEC/MALLS in the range of molecular masses studied. The molecular masses obtained from sedimentation equilibrium for high molecular mass samples from reciprocal plots of apparent weight average molecular mass against concentration gave values similar to those obtained by SEC/MALLS. In contrast, the molecular mass from conventional plots for high molecular mass samples were much lower than those from SEC/MALLS, even when high ionic strength buffers were used.

  20. Online Mall: How One District Got Started in E-Purchasing.

    ERIC Educational Resources Information Center

    Barclay, Brian

    2001-01-01

    To address the problem of outdated vendor catalogs, Edmonton (Alberta) Public Schools created a view-only online shopping mall that evolved into an electronic shopping program. Buyers can use credit cards for some transactions and cost coding for others. They can also sell unwanted items online. (MLH)

  1. Online Mall: How One District Got Started in E-Purchasing.

    ERIC Educational Resources Information Center

    Barclay, Brian

    2001-01-01

    To address the problem of outdated vendor catalogs, Edmonton (Alberta) Public Schools created a view-only online shopping mall that evolved into an electronic shopping program. Buyers can use credit cards for some transactions and cost coding for others. They can also sell unwanted items online. (MLH)

  2. Concierge or Information Desk: Teaching Social Stratification through the Malling of America.

    ERIC Educational Resources Information Center

    Manning, Robert D.; Price, Derek V.; Rich, Henry J.

    1997-01-01

    Describes an undergraduate sociology project in which students conducted research at working class and upper-middle class shopping malls. The research focused on social stratification and its manifestation in architectural character, spatial relationships, advertising, and consumer behavior. Includes an appendix that reproduces the fieldwork…

  3. Comparing Food Label Experiments Using Samples from Web Panels versus Mall Intercepts

    ERIC Educational Resources Information Center

    Chang, LinChiat; Lin, Chung-Tung Jordan

    2015-01-01

    To regulate health messages on food labels, the U.S. Food and Drug Administration (FDA) traditionally relied on mall intercepts to collect consumer data. In recent years, web surveys have presented a viable alternative for presenting visual stimuli with more control and efficiency in data collection. However, there is a paucity of empirical data…

  4. Winning at Child Caring: Easier Ways with Young Children in Child Care Centers, Homes and Malls.

    ERIC Educational Resources Information Center

    Simons, Bette

    This booklet is a compilation of articles from a column in the "Warner Center News" written by an experienced early childhood educator on various topics related to child care. The brief articles describe the problems and pleasures that preschool children bring to child care centers, homes, markets, and malls. The articles are grouped…

  5. Of Mega-Malls and Soft-Shelled Turtles: Deep Ecological Education To Counter Homogeneity.

    ERIC Educational Resources Information Center

    Quinn, Michael S.; Scott, Jennifer R.

    1997-01-01

    Attempts to compare the modern retail/entertainment experience of the mega-mall to a singular encounter with a wild animal in its native community context. Explores the differences between seeking amusement and seeking happiness as well as the capacity for experiencing joy. Concludes with some implications of these experiences to the…

  6. Negotiating Liberalism and Bio-Politics: Stylizing Power in Defense of the Mall Curfew

    ERIC Educational Resources Information Center

    Amsden, Brian

    2008-01-01

    While Michel Foucault's "technologies of the self" are useful in explaining the convergence of liberalism and bio-politics, they fail to account for the appeal of juridical mechanisms that administer the conventions of bio-political control. A productive site from which to explore this convergence is provided by the "mall curfew," a bio-political…

  7. The Effect of MALL-Based Tasks on EFL Learners' Grammar Learning

    ERIC Educational Resources Information Center

    Khodabandeh, Farzaneh; Alian, Jalal ed-din; Soleimani, Hassan

    2017-01-01

    Many studies have confirmed the importance of tasks on language learning. Nowadays, many teachers apply different kinds of tasks in their classrooms. The current study investigated the effect of mobile assisted language learning tasks (MALL) on participants' English grammar learning. The researcher administered a pre-validated grammar test to 90…

  8. MALL Technology: Use of Academic Podcasting in the Foreign Language Classroom

    ERIC Educational Resources Information Center

    Abdous, M'hammed; Camarena, Margaret M.; Facer, Betty Rose

    2009-01-01

    Integrating Mobile Assisted Language Learning (MALL) technology (personal multimedia players, cell phones, and handheld devices) into the foreign language curriculum is becoming commonplace in many secondary and higher education institutions. Current research has identified both pedagogically sound applications and important benefits to students.…

  9. Negotiating Liberalism and Bio-Politics: Stylizing Power in Defense of the Mall Curfew

    ERIC Educational Resources Information Center

    Amsden, Brian

    2008-01-01

    While Michel Foucault's "technologies of the self" are useful in explaining the convergence of liberalism and bio-politics, they fail to account for the appeal of juridical mechanisms that administer the conventions of bio-political control. A productive site from which to explore this convergence is provided by the "mall curfew," a bio-political…

  10. For Our Kids, Going to the Mall Is a Real Education.

    ERIC Educational Resources Information Center

    Ellis, Patti

    1989-01-01

    The Storefront School for mentally disabled youth in Ottawa (Ontario) serves as both a classroom and a headquarters for students who are assigned work in the shopping mall. Visibility of the program makes the public more aware of the potential of the mentally handicapped. (MLF)

  11. Pedestrian Choice Behavior at Shopping Mall Intersections in China and the United States

    ERIC Educational Resources Information Center

    Bitgood, Stephen; Davey, Gareth; Huang, Xiaoyi; Fung, Holly

    2013-01-01

    Pedestrian navigation through public spaces reflects the nature of interaction between behavior and environment. This study compared pedestrian choice behavior at shopping mall intersections in China and the United States. The study found that in both countries (a) pedestrians chose movement patterns that involved the fewest steps and (b) there…

  12. Concierge or Information Desk: Teaching Social Stratification through the Malling of America.

    ERIC Educational Resources Information Center

    Manning, Robert D.; Price, Derek V.; Rich, Henry J.

    1997-01-01

    Describes an undergraduate sociology project in which students conducted research at working class and upper-middle class shopping malls. The research focused on social stratification and its manifestation in architectural character, spatial relationships, advertising, and consumer behavior. Includes an appendix that reproduces the fieldwork…

  13. 18. Photocopy, 'St. Mary's School,' from the commemorative booklet published ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. Photocopy, 'St. Mary's School,' from the commemorative booklet published for the 125th anniversary of St. Mary's Parish, 1980. View Southwest, North Front and East Side, at St. John Street and Church Street (Original in possession of St. Mary's Parish) - St. Mary's Roman Catholic School, Northwest corner of Church Avenue & Guthrie Street, McKees Rocks, Allegheny County, PA

  14. Rehabilitation strategies enhancing participation in shopping malls for persons living with a disability.

    PubMed

    Alary Gauvreau, Christine; Kairy, Dahlia; Mazer, Barbara; Guindon, Andréanne; Le Dorze, Guylaine

    2017-01-27

    After rehabilitation, it is not clear the extent to which persons living with a disability return to their former activities in the community, such as going to shopping malls. Rehabilitation professionals are faced with the challenge to adequately prepare their clients to resume community participation. The purpose of this study was to identify rehabilitation strategies aimed at preparing clients to engage in activities in shopping malls. Twenty-two participants including 16 rehabilitation clinicians and 6 persons living with a disability participated in four nominal group sessions. Participants were questioned on current or potential rehabilitation strategies carried out to enhance participation in shopping malls for persons living with a disability. Discussions were audio-recorded and qualitative content analysis was conducted. Participants mentioned strategies that were either carried out by the clinician, or in collaboration with other parties. The latter type of strategies was either carried out with the collaboration of the client, the interdisciplinary team, the relatives, or community organizations. Rehabilitation clinicians have a role to play in preparing persons living with a disability to resume activities in a shopping mall. Additionally, therapeutic interventions in community settings may enhance the participation of rehabilitation clients in their everyday activities. Implications for rehabilitation Many strategies are currently used in rehabilitation to prepare persons living with a disability to resume shopping activities. Clinicians could implement shopping-oriented rehabilitation strategies with the client and/or with other rehabilitation partners. Involving clients in activities related to shopping might enhance their participation in shopping malls after rehabilitation. Rehabilitation clinicians can be facilitators for people living with a disability to reach optimal participation.

  15. Marie Curie during ORT6

    NASA Technical Reports Server (NTRS)

    2003-01-01

    Marie Curie sits on the lander petal prior to deployment during the pre launch Operations Readiness Test (ORT) 6.

    Pathfinder, a low-cost Discovery mission, is the first of a new fleet of spacecraft that are planned to explore Mars over thenext ten years. Mars Global Surveyor, already en route, arrives at Mars on September 11 to begin a two year orbital reconnaissance of the planet's composition, topography, and climate. Additional orbiters and landers will follow every 26 months.

    The Jet Propulsion Laboratory, Pasadena, CA, developed and manages the Mars Pathfinder mission for NASA's Office of Space Science, Washington, D.C. JPL is an operating division of the California Institute of Technology (Caltech). The Imager for Mars Pathfinder (IMP) was developed by the University of Arizona Lunar and Planetary Laboratory under contract to JPL. Peter Smith is the Principal Investigator.

  16. Marie Curie during ORT4

    NASA Technical Reports Server (NTRS)

    2003-01-01

    Marie Curie rover drives down the rear ramp during Operational Readiness Test (ORT) 4.

    Pathfinder, a low-cost Discovery mission, is the first of a new fleet of spacecraft that are planned to explore Mars over thenext ten years. Mars Global Surveyor, already en route, arrives at Mars on September 11 to begin a two year orbital reconnaissance of the planet's composition, topography, and climate. Additional orbiters and landers will follow every 26 months.

    The Jet Propulsion Laboratory, Pasadena, CA, developed and manages the Mars Pathfinder mission for NASA's Office of Space Science, Washington, D.C. JPL is an operating division of the California Institute of Technology (Caltech). The Imager for Mars Pathfinder (IMP) was developed by the University of Arizona Lunar and Planetary Laboratory under contract to JPL. Peter Smith is the Principal Investigator.

  17. Radium, Marie Curie and modern science.

    PubMed

    Langevin-Joliot, H

    1998-11-01

    In 1898, the discovery of two new elements, polonium and radium, reawakened interest in the topic of uranic rays discovered 2 years before by H. Becquerel. Radioactivity, a name coined by Marie Curie, became a major research field for decades. The contrasting personalities of Pierre Curie, already a first-rank physicist, and of the young Marie Curie-Sklodowska as they undertook their common work are described. It is shown how a well-chosen quantitative method and a systematic approach combining physics and chemistry led to the discovery within less than 1 year. The special role of radium and the determination of its atomic weight by Marie Curie followed by her long-term program for accumulating pure radium salts are emphasized. The first woman with a full professorship at a French University, Marie Curie created and managed the Radium Institute.

  18. [When Marie Bonaparte turned a deaf ear].

    PubMed

    Amouroux, Rémy; Stouten, Hanna

    2014-01-01

    Between 1927 and 1931 Marie Bonaparte had herself operated upon her clitoris three times. She did so against Freud's advice with whom she was in analysis. Among psychoanalysts these operations are still often regarded as "errors" or aberrations. But for Marie Bonaparte, who was in various ways familiar with physics and a somatic approach, surgery was the first choice, psychoanalysis only a possible alternative. She was not impressed by the scepticism of her colleagues, and adhered even more emphatically to her own strategy.

  19. Charcot-Marie-Tooth disease: an update.

    PubMed

    Shy, Michael E

    2004-10-01

    The purpose of this review is to assist neurologists, neuroscientists and other interested readers in following the expanding volume of information relating to the inherited peripheral neuropathies collectively referred to as Charcot-Marie-Tooth disease. Currently, mutations in multiple different genes expressed in Schwann cells and neurons cause a variety of overlapping clinical phenotypes. Recent articles clarify molecular pathways involved in the pathogenesis of these disorders, and for the first time provide rational treatment strategies for the most common form of Charcot-Marie-Tooth disease. The identification of many new genes associated with neuropathy demonstrate the role of axonal transport and abnormal protein trafficking in causing various forms of Charcot-Marie-Tooth. They also further define the role of axonal signaling and the molecular architecture of both Schwann cells and neurons in maintaining normal peripheral nervous system function. Finally, recent reports have shown that progesterone antagonists and ascorbic acid can successfully treat rodent models of Charcot-Marie-Tooth disease type 1A. Taken together, results from these articles support the concept that genetic causes of Charcot-Marie-Tooth disease serve as a living microarray system to identify molecules necessary for normal peripheral nervous system function. When we can make sense of these microarrays we are likely to understand the pathogenesis and develop rational therapies for many neurodegenerative diseases including Charcot-Marie-Tooth.

  20. VisitSense: Sensing Place Visit Patterns from Ambient Radio on Smartphones for Targeted Mobile Ads in Shopping Malls

    PubMed Central

    Kim, Byoungjip; Kang, Seungwoo; Ha, Jin-Young; Song, Junehwa

    2015-01-01

    In this paper, we introduce a novel smartphone framework called VisitSense that automatically detects and predicts a smartphone user’s place visits from ambient radio to enable behavioral targeting for mobile ads in large shopping malls. VisitSense enables mobile app developers to adopt visit-pattern-aware mobile advertising for shopping mall visitors in their apps. It also benefits mobile users by allowing them to receive highly relevant mobile ads that are aware of their place visit patterns in shopping malls. To achieve the goal, VisitSense employs accurate visit detection and prediction methods. For accurate visit detection, we develop a change-based detection method to take into consideration the stability change of ambient radio and the mobility change of users. It performs well in large shopping malls where ambient radio is quite noisy and causes existing algorithms to easily fail. In addition, we proposed a causality-based visit prediction model to capture the causality in the sequential visit patterns for effective prediction. We have developed a VisitSense prototype system, and a visit-pattern-aware mobile advertising application that is based on it. Furthermore, we deploy the system in the COEX Mall, one of the largest shopping malls in Korea, and conduct diverse experiments to show the effectiveness of VisitSense. PMID:26193275

  1. Safe, Affordable, Convenient: Environmental Features of Malls and Other Public Spaces Used by Older Adults for Walking

    PubMed Central

    King, Diane K.; Allen, Peg; Jones, Dina L.; Marquez, David X.; Brown, David R.; Rosenberg, Dori; Janicek, Sarah; Allen, Laila; Belza, Basia

    2016-01-01

    Background Midlife and older adults use shopping malls for walking, but little research has examined mall characteristics that contribute to their walkability. Methods We used modified versions of the Centers for Disease Control and Prevention (CDC)-Healthy Aging Research Network (HAN) Environmental Audit and the System for Observing Play and Recreation in Communities (SOPARC) tool to systematically observe 443 walkers in 10 shopping malls. We also observed 87 walkers in 6 community-based nonmall/nongym venues where older adults routinely walked for physical activity. Results All venues had public transit stops and accessible parking. All malls and 67% of nonmalls had wayfinding aids, and most venues (81%) had an established circuitous walking route and clean, well-maintained public restrooms (94%). All venues had level floor surfaces, and one-half had benches along the walking route. Venues varied in hours of access, programming, tripping hazards, traffic control near entrances, and lighting. Conclusions Despite diversity in location, size, and purpose, the mall and nonmall venues audited shared numerous environmental features known to promote walking in older adults and few barriers to walking. Future research should consider programmatic features and outreach strategies to expand the use of malls and other suitable public spaces for walking. PMID:26181907

  2. Safe, Affordable, Convenient: Environmental Features of Malls and Other Public Spaces Used by Older Adults for Walking.

    PubMed

    King, Diane K; Allen, Peg; Jones, Dina L; Marquez, David X; Brown, David R; Rosenberg, Dori; Janicek, Sarah; Allen, Laila; Belza, Basia

    2016-03-01

    Midlife and older adults use shopping malls for walking, but little research has examined mall characteristics that contribute to their walkability. We used modified versions of the Centers for Disease Control and Prevention (CDC)-Healthy Aging Research Network (HAN) Environmental Audit and the System for Observing Play and Recreation in Communities (SOPARC) tool to systematically observe 443 walkers in 10 shopping malls. We also observed 87 walkers in 6 community-based nonmall/nongym venues where older adults routinely walked for physical activity. All venues had public transit stops and accessible parking. All malls and 67% of nonmalls had wayfinding aids, and most venues (81%) had an established circuitous walking route and clean, well-maintained public restrooms (94%). All venues had level floor surfaces, and one-half had benches along the walking route. Venues varied in hours of access, programming, tripping hazards, traffic control near entrances, and lighting. Despite diversity in location, size, and purpose, the mall and nonmall venues audited shared numerous environmental features known to promote walking in older adults and few barriers to walking. Future research should consider programmatic features and outreach strategies to expand the use of malls and other suitable public spaces for walking.

  3. VisitSense: Sensing Place Visit Patterns from Ambient Radio on Smartphones for Targeted Mobile Ads in Shopping Malls.

    PubMed

    Kim, Byoungjip; Kang, Seungwoo; Ha, Jin-Young; Song, Junehwa

    2015-07-16

    In this paper, we introduce a novel smartphone framework called VisitSense that automatically detects and predicts a smartphone user's place visits from ambient radio to enable behavioral targeting for mobile ads in large shopping malls. VisitSense enables mobile app developers to adopt visit-pattern-aware mobile advertising for shopping mall visitors in their apps. It also benefits mobile users by allowing them to receive highly relevant mobile ads that are aware of their place visit patterns in shopping malls. To achieve the goal, VisitSense employs accurate visit detection and prediction methods. For accurate visit detection, we develop a change-based detection method to take into consideration the stability change of ambient radio and the mobility change of users. It performs well in large shopping malls where ambient radio is quite noisy and causes existing algorithms to easily fail. In addition, we proposed a causality-based visit prediction model to capture the causality in the sequential visit patterns for effective prediction. We have developed a VisitSense prototype system, and a visit-pattern-aware mobile advertising application that is based on it. Furthermore, we deploy the system in the COEX Mall, one of the largest shopping malls in Korea, and conduct diverse experiments to show the effectiveness of VisitSense.

  4. Mall Walking as a Physical Activity Option: Results of a Pilot Project

    ERIC Educational Resources Information Center

    Culos-Reed, S. Nicole; Stephenson, Lynette; Doyle-Baker, Patricia K.; Dickinson, James A.

    2008-01-01

    The purpose of this study was to assess the feasibility and benefits (fitness and quality of life) of an 8-week mall-walking program. A total of 52 participants ( n = 39 at post-testing) took part in the pilot project (mean age = 66.4; range 46-83 years), with an overall attendance rate of 62.4 per cent. Participants self-selected pace, time, and…

  5. Mall Walking as a Physical Activity Option: Results of a Pilot Project

    ERIC Educational Resources Information Center

    Culos-Reed, S. Nicole; Stephenson, Lynette; Doyle-Baker, Patricia K.; Dickinson, James A.

    2008-01-01

    The purpose of this study was to assess the feasibility and benefits (fitness and quality of life) of an 8-week mall-walking program. A total of 52 participants ( n = 39 at post-testing) took part in the pilot project (mean age = 66.4; range 46-83 years), with an overall attendance rate of 62.4 per cent. Participants self-selected pace, time, and…

  6. Case study of total energy system, Sher-Den Mall, Sherman, Texas

    SciTech Connect

    Myrtetus, G.B.; Levey, M.D.

    1980-12-01

    The Sher-Den Mall shopping center receives all of its electricity and heating and cooling energy from a total energy plant located within the shopping center proper. Four engine-generator units are fueled primarily by natural gas, with some fuel oil use. The following are presented: initial corporate planning, investigation, and feasibility studies; a description of the total energy system; capital costs; plant operations, and revenue structure. Tables, figures, exhibits, and equipment specification lists are presented. (MHR)

  7. 11. VIEW LOOKING NORTH ON THE TENTH STREET MALL (L'ENFANT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. VIEW LOOKING NORTH ON THE TENTH STREET MALL (L'ENFANT PROMENADE) TOWARD THE JAMES FORRESTAL BUILDING (FEDERAL OFFICE BUILDING NO. 5) AT 1000 INDEPENDENCE AVENUE; THE FORRESTAL BUILDING WAS DESIGNED BY CURTIS & DAVIS AND COMPLETED IN 1969 - Southwest Washington, Urban Renewal Area, Bounded by Independence Avenue, Washington Avenue, South Capitol Street, Canal Street, P Street, Maine Avenue & Washington Channel, Fourteenth Street, D Street, & Twelfth Street, Washington, District of Columbia, DC

  8. Photographic documentation of the STS-107 Memorial at the JSC Mall

    NASA Image and Video Library

    2003-02-04

    JSC2003-E-05938 (4 February 2003) --- President George W. Bush addresses the crowd on the mall of the Johnson Space Center during the memorial for the Columbia astronauts. Seated from the left are Captain Gene Theriot, Chaplain Corps (USN); NASA Administrator Sean O’Keefe; and astronaut Kent V. Rominger, Chief of the Astronaut Office. A portrait of the STS-107 Columbia crew is visible at left.

  9. Prevalence and construct validity of compulsive buying disorder in shopping mall visitors.

    PubMed

    Maraz, Aniko; van den Brink, Wim; Demetrovics, Zsolt

    2015-08-30

    Compulsive buying is a relatively new psychopathological concept and very few data are currently available regarding the prevalence and validity of compulsive buying disorder. In this cross-sectional study, we establish the prevalence of compulsive buying disorder in shopping mall visitors and explore the construct validity of the concept using the revised version of the Edwards Compulsive Buying Scale in 1441 shopping mall visitors looking at shopping habits, current substance use (smoking, alcohol and illicit drug) and various psychological characteristics. Overall, 8.7% (95% CI: 7.3-10.3) of our sample was classified as having a compulsive buying disorder. Compulsive buyers were younger, less educated and more likely to be female than non-compulsive buyers. They were also more likely to have used licit and illicit substances. Compulsive buyers also reported higher levels of impulsivity and obsessive-compulsive symptoms, lower levels of well-being and self-esteem and more psychological distress. Finally, compulsive buyers were five times more likely to meet criteria for borderline personality disorder than non-compulsive buyers. Compulsive buying is a frequent disorder in shopping mall visitors and is associated with important and robust indicators of psychopathology thus supporting the validity of the construct. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  10. Meet EPA Scientist Marie O'Shea, Ph.D.

    EPA Pesticide Factsheets

    EPA Scientist Dr. Marie O'Shea is Region 2's Liaison to the Agency's Office of Research and Development (ORD). Marie has a background in research on urban watershed management, focused on characterizing and controlling nutrients in stormwater runoff.

  11. 21. Photocopy of drawing (from Sault Ste. Marie, MI city ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    21. Photocopy of drawing (from Sault Ste. Marie, MI city archives) showing ROADWAY ACROSS SECTION DETAILS - Spruce Street Bridge, East Spruce Street, 500 Block, spanning Power Canal, Sault Ste. Marie, Chippewa County, MI

  12. Bit Error Rate of Coherent M-ary PSK

    NASA Technical Reports Server (NTRS)

    Lee, P. J.

    1985-01-01

    The bit error rate (BER) for the coherent detection of M-ary PSK signals with Gray code bit mapping is considered. A closed-form expression for the exact BER of M-ary PSK is presented. Tight upper and lower bounds on BER are also obtained for M-ary PSK with larger M.

  13. Precise and Efficient Retrieval of Captioned Images: The MARIE Project.

    ERIC Educational Resources Information Center

    Rowe, Neil C.

    1999-01-01

    The MARIE project explores knowledge-based information retrieval of captioned images of the kind found in picture libraries and on the Internet. MARIE's five-part approach exploits the idea that images are easier to understand with context, especially descriptive text near them, but it also does image analysis. Experiments show MARIE prototypes…

  14. Precise and Efficient Retrieval of Captioned Images: The MARIE Project.

    ERIC Educational Resources Information Center

    Rowe, Neil C.

    1999-01-01

    The MARIE project explores knowledge-based information retrieval of captioned images of the kind found in picture libraries and on the Internet. MARIE's five-part approach exploits the idea that images are easier to understand with context, especially descriptive text near them, but it also does image analysis. Experiments show MARIE prototypes…

  15. 17. Photocopy, 'St. Mary's New School,' from the commemorative booklet ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. Photocopy, 'St. Mary's New School,' from the commemorative booklet published for the dedication of the school, September 1923. View Southeast, North Front and West Side perspective at Church and Guthrie Street, including Rectory and Church (Original in possession of St. Mary's Parish) - St. Mary's Roman Catholic School, Northwest corner of Church Avenue & Guthrie Street, McKees Rocks, Allegheny County, PA

  16. MaRIE Undulator & XFEL Systems

    SciTech Connect

    Nguyen, Dinh Cong; Marksteiner, Quinn R.; Anisimov, Petr Mikhaylovich; Buechler, Cynthia Eileen

    2015-03-23

    The 22 slides in this presentation treat the subject under the following headings: MaRIE XFEL Performance Parameters, Input Electron Beam Parameters, Undulator Design, Genesis Simulations, Risks, and Summary It is concluded that time-dependent Genesis simulations show the MaRIE XFEL can deliver the number of photons within the required bandwidth, provided a number of assumptions are met; the highest risks are associated with the electron beam driving the XFEL undulator; and risks associated with the undulator and/or distributed seeding technique may be evaluated or retired by performing early validation experiments.

  17. Charcot-Marie-Tooth disease and vincristine.

    PubMed

    Orejana-García, Angel M; Pascual-Huerta, Javier; Pérez-Melero, Andrés

    2003-01-01

    This article reports on a case of sensorimotor neuropathy in a 55-year-old man that developed after vincristine therapy. Subsequent biopsy of the sural nerve and electromyographic studies revealed the presence of Charcot-Marie-Tooth disease. Only 17 patients who developed severe neuropathy with very low accumulated doses of vincristine have been described in the literature. Pain and lateral ankle instability were treated with a functional orthosis. Orthopedic treatment and the biomechanical basis of foot and ankle problems in patients with vincristine therapy-induced Charcot-Marie-Tooth disease are discussed.

  18. [The meadow Mari: inbreeding and endogamy].

    PubMed

    El'chinova, G I; Startseva, E A; Moshkina, I S; Rassanov, V P; Ginter, E K

    1996-09-01

    The genetic structure of Lugovye Maris was studied on the basis of marital migration. Malecot's parameters of isolation and endogamy index were estimated in four rations of the Marii El Republic, which is populated by Maris. High values of the endogamy index (0.80 and 0.88) never observed previously in any Russian populations, were revealed in two rations. The lack of significant correlation between endogamy and local inbreeding was analyzed. A significant correlation (0.70) between endogamy and effective population size was revealed.

  19. Women in History--Mary Seacole

    ERIC Educational Resources Information Center

    Harmer, Bonnie

    2005-01-01

    Born in Jamaica in 1805, Mary Seacole (nee Grant), was the daughter of a Black Creole boarding house owner and a Scottish Army officer. Like many Creole doctress women, Seacole was taught African herbal medicine arts from her mother. In addition to understanding traditional herbal medicine, she gleaned an understanding of Western medicine from the…

  20. Mary Wollstonecraft and Catharine Macaulay on Education

    ERIC Educational Resources Information Center

    Frazer, Elizabeth

    2011-01-01

    Catharine Macaulay and Mary Wollstonecraft are linked by intellectual and political bonds; for both, education is a philosophical and political preoccupation in its own right, and also interacts with philosophical questions of morality, social power, theology, truth and human action. Macaulay's philosophical and political engagements with Hobbes,…

  1. Mary Wollstonecraft and Catharine Macaulay on Education

    ERIC Educational Resources Information Center

    Frazer, Elizabeth

    2011-01-01

    Catharine Macaulay and Mary Wollstonecraft are linked by intellectual and political bonds; for both, education is a philosophical and political preoccupation in its own right, and also interacts with philosophical questions of morality, social power, theology, truth and human action. Macaulay's philosophical and political engagements with Hobbes,…

  2. Mary Slessor (1848-1915), Pedagogue Extraordinary.

    ERIC Educational Resources Information Center

    Taylor, W. H.

    1993-01-01

    Mary Slessor was a Scottish missionary who established many schools in Nigeria and developed close relationships with Nigerian chiefs and tribal members. She championed women's rights and focused her educational endeavors on vocational training relevant to the local economy. Slessor incorporated her knowledge of Nigerian culture into her teaching…

  3. Fumarolic activity in marie byrd land, antarctica.

    PubMed

    Lemasurier, W E; Wade, F A

    1968-10-18

    Ice towers, probably formed by recent fumarolic activity, have been found around the summit calderas of two volcanoes in Marie Byrd Land. These active (?) volcanoes lie within a broad belt of Mesozoic intrusion and late Cenozoic extrusion that appears to be part of the circum-Pacific orogenic province.

  4. Women in History--Mary Seacole

    ERIC Educational Resources Information Center

    Harmer, Bonnie

    2005-01-01

    Born in Jamaica in 1805, Mary Seacole (nee Grant), was the daughter of a Black Creole boarding house owner and a Scottish Army officer. Like many Creole doctress women, Seacole was taught African herbal medicine arts from her mother. In addition to understanding traditional herbal medicine, she gleaned an understanding of Western medicine from the…

  5. Mary Bidwell Breed: The Educator as Dean.

    ERIC Educational Resources Information Center

    Fley, Jo Ann; Jaramillo, George R.

    1979-01-01

    Mary Bidwell Breed predicted that midwestern universities would probably "pass through a stage of educational development in which the liberal arts are entirely feminized, the men are entirely commercialized." We can appreciate how close she came to pinpointing trends which did not begin to be reversed until sixty years later.…

  6. Mary Budd Rowe: A Storyteller of Science

    ERIC Educational Resources Information Center

    Bianchini, Julie A.

    2008-01-01

    This article examines Mary Budd Rowe's groundbreaking and far-reaching contributions to science education. Rowe is best known for her research on wait-time: the idea that teachers can improve the quality and length of classroom discussions by waiting at least 3 s before and after student responses. Her wait-time research grew from and helped…

  7. Mary Somerville: a scientist and her ship.

    PubMed

    Fara, Patricia

    2008-09-01

    Mary Somerville enjoyed posing for busts and portraits, yet just as in her autobiography, she chose how she wished to be seen. A powerful advocate for scientific progress, Somerville gave her name to a ship that carried British products around the world, and portrayed herself as an ideal role model for women and also an exemplar of European civilisation.

  8. Mary Elizabeth Hickox Mandels, 90, bioenergy leader

    PubMed Central

    Allen, Fred; Andreotti, Raymond; Eveleigh, Douglas E; Nystrom, John

    2009-01-01

    Mary E H Mandels, who spearheaded the US Army's national bioconversion studies for four decades and was an early proponent of conversion of waste biomass to readily bioconvertible sugars for the production of chemicals and transportation fuels such as ethanol, died 17 February 2008 at Natick, MA, USA. She was 90. PMID:19723299

  9. Classroom Instruction: The Influences of Marie Clay

    ERIC Educational Resources Information Center

    McNaughton, Stuart

    2014-01-01

    Marie Clay's body of work has influenced classroom instruction in direct and indirect ways, through large overarching themes in our pedagogical content knowledge as well as specific smart practices. This paper focuses on her the contributions to our thinking about instruction which come from two broad theoretical concepts; emergent literacy…

  10. The Saint Mary's Woman: toward Intellectual Leadership.

    ERIC Educational Resources Information Center

    White, Patrick E.

    This two-year project at Saint Mary's College, a women's college in Notre Dame (Indiana), focused on building intellectual community and fostering student leadership skills. The study targeted two student groups: (1) students with much to contribute to the intellectual life of the college but alienated from traditional forms of leadership, and (2)…

  11. Classroom Instruction: The Influences of Marie Clay

    ERIC Educational Resources Information Center

    McNaughton, Stuart

    2014-01-01

    Marie Clay's body of work has influenced classroom instruction in direct and indirect ways, through large overarching themes in our pedagogical content knowledge as well as specific smart practices. This paper focuses on her the contributions to our thinking about instruction which come from two broad theoretical concepts; emergent literacy…

  12. Visions of Mary Wollstonecraft: Implications for Education.

    ERIC Educational Resources Information Center

    Manus, Alice L.

    This paper discusses the educational and social philosophy of Mary Wollstonecraft, an English writer of the 18th century. Her works included "Vindication of the Rights of Man," and her best know work, "Vindication of the Rights of Woman" which was published in 1792 and consisted of the first sustained argument for female…

  13. View of the STS 51-L Memorial service on JSC's main mall

    NASA Technical Reports Server (NTRS)

    1986-01-01

    Memorial services for the Challenger Seven were conducted on the morning of Jan. 31, 1986 at JSC's main mall. Among those in attendance were former and present astronauts and Space Shuttle payload specialists (PS). U.S. Sen. Jake Garn (R., Utah) vists at center with Sultan Salman Abdelazize Al-Saud of Saudi Arabia. Others pictured include German PS Ulf Merbold, French PS Patrick Baudry and NASA Astronauts Robert L. Stewart, Marsha S. Ivins, David C. Leestma and C. Gordon Fullerton, along with former astronaut Eugene A. Cernan.

  14. 8. GENERAL VIEW ALONG L'ENFANT PROMENADE OR TENTH STREET MALL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. GENERAL VIEW ALONG L'ENFANT PROMENADE OR TENTH STREET MALL DESIGNED BY I.M. PEI & PARTNERS LOOKING SOUTH; VIEW INCLUDES THE L'ENFANT PLAZA WEST BUILDING (USPS) AT 475 L'ENFANT PLAZA WAS DESIGNED BY VLASTIMIL KOUBEK AND COMPLETED IN 1971 AND, TO THE EAST, THE NASA BUILDING AS WELL AS THE ASTRAL BUILDING AND COMSAT BUILDING, BOTH OF WHICH WERE DESIGNED BY ARALDO A. COSSUTTA, OF I.M. PEI & PARTNERS, IN 1968 - Southwest Washington, Urban Renewal Area, Bounded by Independence Avenue, Washington Avenue, South Capitol Street, Canal Street, P Street, Maine Avenue & Washington Channel, Fourteenth Street, D Street, & Twelfth Street, Washington, District of Columbia, DC

  15. Volatile organic compounds in a multi-storey shopping mall in guangzhou, South China

    NASA Astrophysics Data System (ADS)

    Tang, Jianhui; Chan, C. Y.; Wang, Xinming; Chan, L. Y.; Sheng, Guoying; Fu, Jiamo

    Volatile organic compounds (VOCs) specified in the USEPA TO-14 list were analysed in microenvironments of a multi-storey shopping mall in Guangzhou city, South China. The microenvironments studied include both indoor (department store, supermarket, fast-food court, electronic games room, children's playground, gallery and book store) and outdoor ones (rooftop and ground level entrance). The characteristics and concentration of VOCs varied widely in differing microenvironments. The average concentrations of the total VOCs in the indoor microenvironments ranged from 178.5 to 457.7 μg m -3 with a maximum of 596.8 μg m -3. The fast-food court and a leather products department store had the highest concentrations of benzene, toluene, ethylbenzene, xylenes and chlorinated hydrocarbons. A high level of 1,4-dichlorobenzene was found in all indoor microenvironments with an average of 12.3 μg m -3 and a maximum of 44.3 μg m -3. The ratios of average indoor to outdoor concentrations (I/O ratio) in all indoor microenvironments fell between 1 and 3, except an average of 24.6 and a maximum of 77.8 in the fashion department store for 1,4-dichlorobenzene. Indoor emission sources of monocyclic aromatic hydrocarbons in the shopping mall might include cooking stoves, leather products and building materials. Chlorinated hydrocarbons, however, were possibly connected with their use as cleaning agents or deodorizers.

  16. SEC-MALLS ANALYSIS OF HYALURONAN SIZE DISTRIBUTIONS MADE BY MEMBRANE-BOUND HYALURONAN SYNTHASE

    PubMed Central

    Baggenstoss, Bruce A.; Weigel, Paul H.

    2006-01-01

    SEC-MALLS analyses of E. coli membranes expressing Streptococcus equisimilis hyaluronan synthase (seHAS) demonstrated an inherent artifact (10–100 MDa) that co-eluted with HA, and skewed the apparent weight-average mass of HA to erroneously high values. Briefly heating samples to 65–75°C eliminated this artifact and increased the yield of recovered HA, due to the release of HA chains that were attached to membrane-bound HAS. Inclusion of alkaline phosphatase, which removed UDP produced during the reaction, improved the linearity of HA synthesis - even at high substrate utilization. Surprisingly, addition of EDTA, to chelate Mg+2 ions, did not completely stop the HAS reaction at 30°C or at 4°C. The best conditions for stopping the reaction without altering SEC-MALLS profiles of the product HA were to chill samples on ice in the presence of both EDTA and UDP. Even with excess substrate, the maximum size of product HA decreased as the enzyme concentration increased. Therefore, the maximum HA size made by HAS was determined by extrapolation to zero enzyme concentration. Using the above conditions, membrane-bound seHAS synthesized a cohort of HA products that steadily increased in weight-average molar mass, reaching a final maximal steady-state size of 4–6 MDa within 2–4 hours. PMID:16476403

  17. Automatic detection of suspicious behavior of pickpockets with track-based features in a shopping mall

    NASA Astrophysics Data System (ADS)

    Bouma, Henri; Baan, Jan; Burghouts, Gertjan J.; Eendebak, Pieter T.; van Huis, Jasper R.; Dijk, Judith; van Rest, Jeroen H. C.

    2014-10-01

    Proactive detection of incidents is required to decrease the cost of security incidents. This paper focusses on the automatic early detection of suspicious behavior of pickpockets with track-based features in a crowded shopping mall. Our method consists of several steps: pedestrian tracking, feature computation and pickpocket recognition. This is challenging because the environment is crowded, people move freely through areas which cannot be covered by a single camera, because the actual snatch is a subtle action, and because collaboration is complex social behavior. We carried out an experiment with more than 20 validated pickpocket incidents. We used a top-down approach to translate expert knowledge in features and rules, and a bottom-up approach to learn discriminating patterns with a classifier. The classifier was used to separate the pickpockets from normal passers-by who are shopping in the mall. We performed a cross validation to train and evaluate our system. In this paper, we describe our method, identify the most valuable features, and analyze the results that were obtained in the experiment. We estimate the quality of these features and the performance of automatic detection of (collaborating) pickpockets. The results show that many of the pickpockets can be detected at a low false alarm rate.

  18. Women who Worked with Marie Curie.

    PubMed

    Pigeard-Micault, Natalie

    2015-06-01

    Marie Curie directed a research laboratory for 28 years. Between 1906 and 1934, forty five women worked under her guidance. Some were, and are, well-known in their own countries as their first woman full professor such as Ellen Gleditsch or Margaret von Wrangel, but for twenty eight of them, who were often French, nothing has ever been written. The strong presence of women in Marie Curie's laboratory has often been highlighted and has been considered as an exception, and the result of deliberate choice. Of course, these women did not choose this workplace by accident. They knew its director was a woman, a laureate of one, and after 1911, two Nobel Prizes, who was leading a well-equipped laboratory with an important radioactive source. But how did Marie Curie selected her collaborators among the many applications she received? Was her choice influenced by gender? A prosopographical research based on genealogical researches and new sources explains this presence contextually and sheds light on several questions : where did these women come from, what were their social and geographic origins, did they occupy any specific cultural or technical area inside Curie's lab, what future did they have after the laboratory? Through their lives, we can question the existence, or not, of a one profile of the female researcher in scientific areas in France.

  19. Mary Grant Seacole: the first nurse practitioner.

    PubMed

    Messmer, P R; Parchment, Y

    1998-01-01

    Mary Grant Seacole was born in 1805, in Kingston, Jamaica, to a Jamaican doctress (medicine woman) and a Scottish naval officer. Later Seacole became a doctress, nursing British soldiers during epidemics of cholera, dysentery, and yellow fever in Jamaica, Cuba, and Panama. After refusals by both the British government and Florence Nightingale to be allowed to practice in Scutari, she financed her own way to the scene of the Crimean War and then established the British Hotel to serve both the comfort and medical needs of the wounded soldiers. At night, Seacole worked side by side with Nightingale at Scutari as a volunteer nurse. Seacole's fame grew proportionately after she was seen helping wounded soldiers on the battlefields even while the battles were still raging. Seacole died on May 14, 1881, in London. One hundred years later, many members of the London black community, a few members of the Nurses Association of Jamaica and the Friends of Mary Seacole marched to her grave, honoring her as one of the greatest women of all times. Mary Grant Seacole rose above the barriers of racial prejudice and demonstrated the determinism, compassion, and caring that have became the hallmark of nurse practitioners.

  20. MALL--Somewhere between the Tower, the Field, the Classroom and the Market: A Reply to Professor Stockwell's Response

    ERIC Educational Resources Information Center

    Ballance, Oliver James

    2013-01-01

    In the previous issue of "LLT", I commented upon Stockwell (2010), suggesting that the learning activities investigated limited the scope of his research on the effects of the MALL platform. Professor Stockwell responded in the same issue with a spirited riposte. However, it became clear that much of the disagreement lay in a matter of definition.…

  1. The Impact of Utilising Mobile Assisted Language Learning (MALL) on Vocabulary Acquisition among Migrant Women English Learners

    ERIC Educational Resources Information Center

    Ahmad, Kham Sila; Armarego, Jocelyn; Sudweeks, Fay

    2017-01-01

    Aim/Purpose: To develop a framework for utilizing Mobile Assisted Language Learning (MALL) to assist non-native English migrant women to acquire English vocabulary in a non-formal learning setting. Background: The women in this study migrated to Australia with varied backgrounds including voluntary or forced migration, very low to high levels of…

  2. NASA and Mary J. Blige Encourage Exciting Careers For Women

    NASA Image and Video Library

    NASA is collaborating with award-winning recording artist Mary J. Blige to encourage young women to pursue exciting experiences and career choices through studying science, technology, engineering ...

  3. RAINWATER FLOODING AND ITS COUNTER MEASURES IN URBAN AREA OF MEGA-UNDERGROUND MALL

    NASA Astrophysics Data System (ADS)

    Morikane, Masayuki; Ishigaki, Taisuke; Ozaki, Taira; Toda, Keiichi

    Frequency of rainfalls over the capacity of drainage system is increasing and underground inundations occurred in some Japanese cities in recent years. It is an urgent matter that managers of underground spaces plan for safe evacuation of users. In order to make the plan, they should know when and from which entrances the rainwater will flow into there. In this paper, inflow discharge was calculated by using 1D-2D urban drainage model in a drainage basin where one of mega-underground mall is located. And appropriate counter measures were investigated. From the results, it is found that peak discharge of inflow appears behind the rainfall peak and that the delay time is from 0.5 to 2.5 hours and depends on the rainfall conditions. It means that several rainfalls should be considered for planning of counter measures and evacuation.

  4. STS-101 Crew Interview / Mary Ellen Weber

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Live footage of a preflight interview with Mission Specialist Mary Ellen Weber is seen. The interview addresses many different questions including why Weber became an astronaut, the events that led to her interest in chemistry and sky diving. Other interesting information that this one-on-one interview discusses is the reaction and reasons for the change of the mission objectives. Weber also mentions the scheduled space-walk, docking with the International Space Station (ISS), the repairs of equipment and change of the batteries, and the installation of handrails. Weber also discusses her responsibilities during the space-walk, and docking of the spacecraft.

  5. Marie Curie's contribution to Medical Physics.

    PubMed

    Jean-Claude, Rosenwald; Nüsslin, Fridtjof

    2013-09-01

    On occasion of its 50th anniversary, the International Organization for Medical Physics (IOMP) from now on is going to celebrate annually an International Day of Medical Physics for which the 7th November, the birthday of Marie Sklodowska Curie, a most exceptional character in science at all and a pioneer of medical physics, has been chosen. This article briefly outlines her outstanding personality, sketches her fundamental discovery of radioactivity and emphasizes the impact of her various achievements on the development of medical physics at large. © 2013 Published by Elsevier Ltd on behalf of Associazione Italiana di Fisica Medica.

  6. Gifts from Mary Ainsworth and John Bowlby.

    PubMed

    Crittenden, Patricia M

    2017-07-01

    Attachment theory has developed over many decades - and continues to develop. Its roots lie in several seminal publications of John Bowlby (the basis of attachment theory) and Mary D. S. Ainsworth (the notion of individual differences in attachment). This paper identifies the prescient contributions of these early publications and two processes (a long-term dialogue and reflection on discrepancy) that underlay emergent theory. Because I was a student of Ainsworth when both attachment theory and individual differences in attachment organization were becoming better known, I offer some of my recollections of that period, suggesting how that period may have affected current work in attachment.

  7. Mary Budd Rowe: a storyteller of science

    NASA Astrophysics Data System (ADS)

    Bianchini, Julie A.

    2008-12-01

    This article examines Mary Budd Rowe's groundbreaking and far-reaching contributions to science education. Rowe is best known for her research on wait-time: the idea that teachers can improve the quality and length of classroom discussions by waiting at least 3 s before and after student responses. Her wait-time research grew from and helped inform her staunch advocacy of science education as inquiry; Rowe saw wonder and excitement as central to the teaching and learning of science. She spent much of her professional life designing professional development experiences and innovative curriculum materials to help teachers, particularly elementary school teachers, enact inquiry in their classrooms.

  8. Pediatric Charcot-Marie-Tooth disease.

    PubMed

    Jani-Acsadi, Agnes; Ounpuu, Sylvia; Pierz, Kristan; Acsadi, Gyula

    2015-06-01

    Heritable diseases of the peripheral nerves (Charcot-Marie-Tooth disease [CMT]) affect the motor units and sensory nerves, and they are among the most prevalent genetic conditions in the pediatric patient population. The typical clinical presentation includes distal muscle weakness and atrophy, but the severity and progression are largely variable. Improvements in supportive treatment have led to better preservation of patients' motor functions. More than 80 genes have been associated with CMT. These genetic discoveries, along with the developments of cellular and transgenic disease models, have allowed clinicians to better understand the disease mechanisms, which should lead to more specific treatments.

  9. Jean-Marie Mariotti Center for Interferometry

    NASA Astrophysics Data System (ADS)

    Chelli, Alain; Duvert, Gilles; Bonneau, Daniel; Perrin, Guy S.; Thiebaut, Eric M.; Mourard, Denis; Petrov, Romain G.; Cruzalebes, Pierre; Lopez, Bruno; Malbet, Fabien; Daigne, Gerard; Ollivier, Marc

    2003-02-01

    The Jean-Marie Mariotti Center is a network of 11 French Institutes, Laboratories or Observatories, appointed by CNRS in 2000. It coordinates the efforts of the member institutes to offer all the potential users of interferometric facilities the best operational environment, providing software, academic formation and stimulating the prospective on new interferometric developments. At present, besides academic formation, the major effort is focused on the development of the software to prepare the observations, to reduce the data and to interpret the results in terms of models or reconstructed images. In this contribution, we describe the achievements and the future plans of the Mariotti Center.

  10. Water resources of St. Mary Parish, Louisiana

    USGS Publications Warehouse

    Prakken, Lawrence B.; White, Vincent E.; Lovelace, John K.

    2014-01-01

    Information concerning the availability, use, and quality of water in St. Mary Parish, Louisiana, is critical for proper water-supply management. The purpose of this fact sheet is to present information that can be used by water managers, parish residents, and others for management of this vital resource. Information on the availability, past and current use, use trends, and water quality from groundwater and surface-water sources in the parish is presented. Previously published reports and data stored in the U.S. Geological Survey’s National Water Information System (http://waterdata.usgs.gov/nwis) are the primary sources of the information presented here.

  11. 33 CFR 117.329 - St. Marys River.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false St. Marys River. 117.329 Section 117.329 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Florida § 117.329 St. Marys River. The draws of US17...

  12. Genetics Home Reference: Charcot-Marie-Tooth disease

    MedlinePlus

    ... Roussy-Lévy syndrome Genetic Testing Registry: X-linked hereditary motor and sensory neuropathy Other Diagnosis and Management Resources (16 links) GeneReview: Charcot-Marie-Tooth Hereditary Neuropathy Overview GeneReview: Charcot-Marie-Tooth Neuropathy Type ...

  13. 33 CFR 117.653 - St. Mary's Falls Canal.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false St. Mary's Falls Canal. 117.653 Section 117.653 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Michigan § 117.653 St. Mary's Falls Canal. The draw...

  14. Marie and Pierre Curie and radium: history, mystery, and discovery.

    PubMed

    Mould, R F

    1999-09-01

    Commencing with Marie Curie's early life in Poland and the discovery of radium in the rue l'Homond "shed" in Paris in 1898, this paper includes some little known facts. It ends with some unusual uses of and claims for radium, and finally, because Medical Physics is an American journal, details are included of Marie Curie's two visits to the USA.

  15. Exploration of the Mars Radiation Environment Using MARIE

    NASA Technical Reports Server (NTRS)

    Cucinotta, F.; Badhwar, G.; Zeitlin, C.; Cleghorn, T.; Bahr, J.; Beyer, T.; Chambellan, C.; Delaune, P.; Dunn, R.; Flanders, J.

    2002-01-01

    One of three science instruments onboard Mars Odyssey is the Mars Radiation Environment Experiment (MARIE), which is described here. MARIE is an energetic particle spectrometer which will characterize the space radiation environment of Mars and determine its risk to human exploration. Additional information is contained in the original extended abstract.

  16. Results from the Martian Radiation Environment Experiment MARIE

    NASA Technical Reports Server (NTRS)

    Zeitlin, C.; Cleghorn, T.; Cucinotta, F.; Saganti, P.; Andersen, V.; Lee, K.; Pinsky, L.; Atwell, W.; Turner, R.

    2003-01-01

    One of the three science instruments aboard the 2001 Mars Odyssey spacecraft is the Martian Radiation Environment Experiment, MARIE. MARIE consists of a stack of silicon detectors, augmented by a Cerenkov detector. MARIE is designed to measure a portion of the particle spectrum of the Galactic Cosmic Rays (GCR), as well as the high fluxes of low-energy protons (energies less than about 100 MeV) that are intermittently produced by active regions on the sun in Solar Particle Events (SPE). MARIE is providing the first detailed information about the radiation environment near Mars.measurements. MARIE has been operating successfully for nearly a year. Solar particle events of considerable interest have been observed, and data have been obtained that will yield GCR spectra from a novel observation point in the solar system.

  17. Roadmap to MaRIE March 2015

    SciTech Connect

    Barnes, Cris William

    2015-03-30

    Los Alamos National Laboratory’s proposed MaRIE facility is slated to introduce the world’s highest energy hard x-ray free electron laser (XFEL). As the light source for the Matter-Radiation Interactions in Extremes experimental facility (MaRIE), the 42-keV XFEL, with bursts of x-ray pulses at gigahertz repetition for studying fast dynamical processes, will help accelerate discovery and design of the advanced materials needed to meet 21st-century national security and energy security challenges. Yet the science of free-electron lasers has a long and distinguished history at Los Alamos National Laboratory (LANL), where for nearly four decades Los Alamos scientists have been performing research, design, development, and collaboration work in FEL science. The work at Los Alamos has evolved from low-gain amplifier and oscillator FEL development to highbrightness photoinjector development, and later, self-amplified spontaneous emission (SASE) and high-gain amplifier FEL development.

  18. A simple health sign increases stair use in a shopping mall and two train stations in Flanders, Belgium.

    PubMed

    Boen, Filip; Maurissen, Katrien; Opdenacker, Joke

    2010-06-01

    The aim of this study was to test the impact of a simple health-promotion sign on stair use in three community settings in Flanders, Belgium. A health sign was placed at the junction between the stairs and an escalator in a shopping mall and two train stations. Observations took place on four days: baseline, first intervention, post-intervention and second intervention. In the second station, a second post-intervention phase was added. In total, 1437 choices of shoppers were registered in the mall, while 2869 and 2025 choices of commuters were recorded in the two stations, respectively. Despite the different baselines of stair use, the introduction of the health sign in the first intervention phase resulted in a significant increase in all three settings: 10.0% increase in the mall, 8.6% in the first station and 18.0% in the second station. In the second station, the increase during the second intervention exceeded that of the first intervention. Moreover, in this station stair use in the second post-intervention phase was significantly higher than at baseline. An inexpensive health-promoting sign has a substantial effect on the proportion of stair users among shoppers and commuters. Preliminary evidence was found that repeated exposure to a health sign might have a longer term effect on stair use.

  19. Diagnosis of Charcot-Marie-Tooth Disease

    PubMed Central

    Banchs, Isabel; Casasnovas, Carlos; Albertí, Antonia; De Jorge, Laura; Povedano, Mónica; Montero, Jordi; Martínez-Matos, Juan Antonio; Volpini, Victor

    2009-01-01

    Charcot-Marie-Tooth (CMT) disease or hereditary motor and sensory neuropathy (HMSN) is a genetically heterogeneous group of conditions that affect the peripheral nervous system. The disease is characterized by degeneration or abnormal development of peripheral nerves and exhibits a range of patterns of genetic transmission. In the majority of cases, CMT first appears in infancy, and its manifestations include clumsiness of gait, predominantly distal muscular atrophy of the limbs, and deformity of the feet in the form of foot drop. It can be classified according to the pattern of transmission (autosomal dominant, autosomal recessive, or X linked), according to electrophysiological findings (demyelinating or axonal), or according to the causative mutant gene. The classification of CMT is complex and undergoes constant revision as new genes and mutations are discovered. In this paper, we review the most efficient diagnostic algorithms for the molecular diagnosis of CMT, which are based on clinical and electrophysiological data. PMID:19826499

  20. The life and legacy of Marie Curie.

    PubMed Central

    Rockwell, Sara

    2003-01-01

    Marie Curie was a remarkable woman whose discoveries broke new ground in physics and chemistry and also opened the door for advances in engineering, biology, and medicine. She broke new ground for women in science: she was, for example, the first woman to receive a doctor of science degree in France, the first woman to win Nobel Prize, the first woman to lecture at the Sorbonne, the first person to win two Nobel Prizes, and the first Nobel Laureate whose child also won a Nobel Prize. Her life offers insights into the changing role of women in science and academia over the past century. It also offers examples of many ways in which scientists can, and should, work to improve the educational programs and career opportunities available to those who follow in their footsteps. Images Figure 1 Figure 2 Figure 3 PMID:15482656

  1. The life and legacy of Marie Curie.

    PubMed

    Rockwell, Sara

    2003-01-01

    Marie Curie was a remarkable woman whose discoveries broke new ground in physics and chemistry and also opened the door for advances in engineering, biology, and medicine. She broke new ground for women in science: she was, for example, the first woman to receive a doctor of science degree in France, the first woman to win Nobel Prize, the first woman to lecture at the Sorbonne, the first person to win two Nobel Prizes, and the first Nobel Laureate whose child also won a Nobel Prize. Her life offers insights into the changing role of women in science and academia over the past century. It also offers examples of many ways in which scientists can, and should, work to improve the educational programs and career opportunities available to those who follow in their footsteps.

  2. Update on Charcot-Marie-Tooth Disease

    PubMed Central

    Patzkó, Ágnes; Shy, Michael E.

    2011-01-01

    Charcot-Marie-Tooth disease (CMT) disease encompasses a genetically heterogeneous group of inherited neuropathies, also known as hereditary motor and sensory neuropathies. CMT results from mutations in more than 40 genes expressed in Schwann cells and neurons causing overlapping phenotypes. The classic CMT phenotype reflects length-dependent axonal degeneration characterized by distal sensory loss and weakness, deep tendon reflex abnormalities, and skeletal deformities. Recent articles have provided insight into the molecular pathogenesis of CMT, which, for the first time, suggest potential therapeutic targets. Although there are currently no effective medications for CMT, multiple clinical trials are ongoing or being planned. This review will focus on the underlying pathomechanisms and diagnostic approaches of CMT and discuss the emerging therapeutic strategies. PMID:21080241

  3. Mary Anning: the fossilist as exegete.

    PubMed

    Goodhue, Thomas W

    2005-03-01

    The fossil hunter Mary Anning began collecting her 'curiosities' at a time when the age and nature of these relics from the past were little understood. Her spectacular discoveries of prehistoric marine reptiles, fossilized fish and a pterosaur touched off a geology-mania around the world. Two documents that have escaped previous analysis cast light on the religious journey of this remarkable woman. An eight-page manuscript at the Natural History Museum in London indicates a fascination with Benjamin West's painting 'Christ Rejected' and sophistication in Biblical interpretation; and a commonplace book at the Dorset County Museum in Dorchester tracks the shift in her Christian denomination from dissent to the Established Church, providing further indication of her spiritual depth - a piety that furthered, rather than hindered, her scientific progress.

  4. Exploring the Universe with John Milton and Mary Shelley.

    ERIC Educational Resources Information Center

    Poston, David

    1989-01-01

    Presents an approach to teaching John Milton's "Paradise Lost" in conjunction with Mary Shelley's "Frankenstein." Notes that a study of these works stimulates vigorous discussions on theological and moral issues, human nature, and the cultural past and future. (MM)

  5. 4. VIEW OF SILVER BRIDGE (ST. MARY'S BRIDGE), CARRYING COUNTY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. VIEW OF SILVER BRIDGE (ST. MARY'S BRIDGE), CARRYING COUNTY ROAD OVER SOURIS RIVER NEAR SOUTH END OF REFUGE, LOOKING NORTHEAST - Upper Souris National Wildlife Refuge Dams, Souris River Basin, Foxholm, Surrey (England), ND

  6. Deployment of Autonomous GPS Stations in Marie Byrd Land, Antartica

    NASA Technical Reports Server (NTRS)

    Donnellan, A.; Luyendyk, B.; Smith, M.; Dace, G.

    1999-01-01

    During the 1998-1999 Antarctic field season, we installed three autonomous GPS stations in Marie Byrd Land, West Antarctica to measure glacio-isostatic rebound and rates of spreading across the West Antartic Rift System.

  7. Marie Curie's Doctoral Thesis: Prelude to a Nobel Prize.

    ERIC Educational Resources Information Center

    Wolke, Robert L.

    1988-01-01

    Traces the life and research techniques of Marie Curie's doctoral dissertation leading to the discovery and purification of radium from ore. Reexamines the discoveries of other scientists that helped lead to this separation. (ML)

  8. Exploring the Universe with John Milton and Mary Shelley.

    ERIC Educational Resources Information Center

    Poston, David

    1989-01-01

    Presents an approach to teaching John Milton's "Paradise Lost" in conjunction with Mary Shelley's "Frankenstein." Notes that a study of these works stimulates vigorous discussions on theological and moral issues, human nature, and the cultural past and future. (MM)

  9. 10. Historic American Buildings Survey W. N. Manning, Photographer, Mary ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Historic American Buildings Survey W. N. Manning, Photographer, Mary 17, 1935 FIREPLACE IN LIVING ROOM, N.E. ROOM - Lewis Llewellyn Cato House, 823 West Barbour Street, Eufaula, Barbour County, AL

  10. Students Speak With Vacuum Chamber Project Manager Mary Cerimele

    NASA Image and Video Library

    From the International Space Station Flight Control Room at NASA's Johnson Space Center, Vacuum Chamber A Project Manager Mary Cerimele participates in a Digital Learning Network (DLN) event with s...

  11. Mary Carpenter: 19th Century English Correctional Education Hero.

    ERIC Educational Resources Information Center

    Gehring, Thom; Bowers, Fredalene B.

    2003-01-01

    Describes Mary Carpenter's (1807-1877) work in prison reform and correctional education. Provides biographical information and selections from her writings. (Contains 11 references and a chronology of her work.) (JOW)

  12. Mary Carpenter: 19th Century English Correctional Education Hero.

    ERIC Educational Resources Information Center

    Gehring, Thom; Bowers, Fredalene B.

    2003-01-01

    Describes Mary Carpenter's (1807-1877) work in prison reform and correctional education. Provides biographical information and selections from her writings. (Contains 11 references and a chronology of her work.) (JOW)

  13. 3. Photocopy of photograph (location of original unknown) Mary Mather, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Photocopy of photograph (location of original unknown) Mary Mather, photographer, ca. 1920 PARTIAL EAST ELEVATION, OBSCURED BY FOLIAGE - Bagatelle Plantation, East River Road (moved to Iberville Parish), Donaldsonville, Ascension Parish, LA

  14. 2. Photocopy of photograph (location of original unknown) Mary Mather, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Photocopy of photograph (location of original unknown) Mary Mather, photographer, ca. 1920 GENERAL VIEW OF WEST (LEFT) AND SOUTH (RIGHT) FACADES, TAKEN FROM LEVEE - Bagatelle Plantation, East River Road (moved to Iberville Parish), Donaldsonville, Ascension Parish, LA

  15. Marie Curie's Doctoral Thesis: Prelude to a Nobel Prize.

    ERIC Educational Resources Information Center

    Wolke, Robert L.

    1988-01-01

    Traces the life and research techniques of Marie Curie's doctoral dissertation leading to the discovery and purification of radium from ore. Reexamines the discoveries of other scientists that helped lead to this separation. (ML)

  16. Martian Radiation Environment: Model Calculations and Recent Measurements with "MARIE"

    NASA Technical Reports Server (NTRS)

    Saganti, P. B.; Cucinotta, F. A.; zeitlin, C. J.; Cleghorn, T. F.

    2004-01-01

    The Galactic Cosmic Ray spectra in Mars orbit were generated with the recently expanded HZETRN (High Z and Energy Transport) and QMSFRG (Quantum Multiple-Scattering theory of nuclear Fragmentation) model calculations. These model calculations are compared with the first eighteen months of measured data from the MARIE (Martian Radiation Environment Experiment) instrument onboard the 2001 Mars Odyssey spacecraft that is currently in Martian orbit. The dose rates observed by the MARIE instrument are within 10% of the model calculated predictions. Model calculations are compared with the MARIE measurements of dose, dose-equivalent values, along with the available particle flux distribution. Model calculated particle flux includes GCR elemental composition of atomic number, Z = 1-28 and mass number, A = 1-58. Particle flux calculations specific for the current MARIE mapping period are reviewed and presented.

  17. MACKINAW UNDERWAY ON MARCH 21, 1994, FROM SAULTE SAINTE MARIE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    MACKINAW UNDERWAY ON MARCH 21, 1994, FROM SAULTE SAINTE MARIE TO WHITEFISH BAY AND BACK; LOOKING AFT FROM BRIDGE WING, FIRST DAY OF BREAK UP OF SHIPPING CHANNEL - U.S. Coast Guard Icebreaker Mackinaw, Cheboygan, Cheboygan County, MI

  18. Mary Tyler Moore Helps Launch NIH MedlinePlus Magazine

    MedlinePlus

    ... Issues Mary Tyler Moore Helps Launch NIH MedlinePlus Magazine Past Issues / Winter 2007 Table of Contents For ... Javascript on. Among those attending the NIH MedlinePlus magazine launch on Capitol Hill were (l-r) NIH ...

  19. Molecular Identification of a Dietzia maris Hip Prosthesis Infection Isolate

    PubMed Central

    Pidoux, O.; Argenson, J.-N.; Jacomo, V.; Drancourt, M.

    2001-01-01

    Dietzia maris, an environmental actinomycete, has been implicated only once in human disease. We herein report the first D. maris isolate from a bone biopsy specimen in a patient hospitalized for a total hip prosthesis replacement. Cell wall fatty acid analysis and 16S ribosomal DNA gene sequencing were utilized to achieve its definite identification. This case report illustrates the usefulness of such methods for the accurate identification of actinomycetes. PMID:11427581

  20. Monte Carlo Simulations of the Response of the MARIE Instrument

    NASA Technical Reports Server (NTRS)

    Andersen, V.; Lee, K.; Pinsky, L.; Atwell, W.; Cleghorn, T.; Cucinotta, F.; Saganti, P.; Turner, R.; Zeitlin, C.

    2003-01-01

    The MARIE instrument aboard Mars Odyssey functions as a telescope for the detection of charged, energetic, nuclei. The directionality that leads to the telescope description is achieved by requiring coincident signals in two designated detectors in MARIE s silicon detector stack for the instrument to trigger. Because of this, MARIE is actually a bi directional telescope. Triggering particles can enter the detector stack by passing through the lightly shielded front of the instrument, but can also enter the back of the instrument by passing through the bulk of Odyssey. Because of this, understanding how to relate the signals recorded by MARIE to astrophysically important quantities such as particle fluxes or spectra exterior to the spacecraft clearly requires detailed modeling of the physical interactions that occur as the particles pass through the spacecraft and the instrument itself. In order to facilitate in the calibration of the MARIE data, we have begun a program to simulate the response of MARIE using the FLUKA [1] [2] Monte Carlo radiation transport code.

  1. Monte Carlo Simulations of the Response of the MARIE Instrument

    NASA Technical Reports Server (NTRS)

    Andersen, V.; Lee, K.; Pinsky, L.; Atwell, W.; Cleghorn, T.; Cucinotta, F.; Saganti, P.; Turner, R.; Zeitlin, C.

    2003-01-01

    The MARIE instrument aboard Mars Odyssey functions as a telescope for the detection of charged, energetic, nuclei. The directionality that leads to the telescope description is achieved by requiring coincident signals in two designated detectors in MARIE s silicon detector stack for the instrument to trigger. Because of this, MARIE is actually a bi directional telescope. Triggering particles can enter the detector stack by passing through the lightly shielded front of the instrument, but can also enter the back of the instrument by passing through the bulk of Odyssey. Because of this, understanding how to relate the signals recorded by MARIE to astrophysically important quantities such as particle fluxes or spectra exterior to the spacecraft clearly requires detailed modeling of the physical interactions that occur as the particles pass through the spacecraft and the instrument itself. In order to facilitate in the calibration of the MARIE data, we have begun a program to simulate the response of MARIE using the FLUKA [1] [2] Monte Carlo radiation transport code.

  2. MaRIE theory, modeling and computation roadmap executive summary

    SciTech Connect

    Lookman, Turab

    2010-01-01

    The confluence of MaRIE (Matter-Radiation Interactions in Extreme) and extreme (exascale) computing timelines offers a unique opportunity in co-designing the elements of materials discovery, with theory and high performance computing, itself co-designed by constrained optimization of hardware and software, and experiments. MaRIE's theory, modeling, and computation (TMC) roadmap efforts have paralleled 'MaRIE First Experiments' science activities in the areas of materials dynamics, irradiated materials and complex functional materials in extreme conditions. The documents that follow this executive summary describe in detail for each of these areas the current state of the art, the gaps that exist and the road map to MaRIE and beyond. Here we integrate the various elements to articulate an overarching theme related to the role and consequences of heterogeneities which manifest as competing states in a complex energy landscape. MaRIE experiments will locate, measure and follow the dynamical evolution of these heterogeneities. Our TMC vision spans the various pillar science and highlights the key theoretical and experimental challenges. We also present a theory, modeling and computation roadmap of the path to and beyond MaRIE in each of the science areas.

  3. Referrals to the Marie Curie nursing service in North Yorkshire.

    PubMed

    Hanratty, B; Feather, J; Ward, C

    2000-01-01

    District and Marie Curie nurses participated in a small-scale study to describe referrals to a Marie Curie service in one English health district over a 3-month period. The number of new patients referred was small; they were geographically clustered and had widely differing life expectancies. Anecdotal reports of difficulties with the 'Nurselink' referral system were not confirmed, and in situations where the system was in operation, Marie Curie nurses were more likely to speak directly to the referring nurse. The most frequently cited reason for referral was general nursing needs; however, Marie Curie nurses felt that they were most often involved to provide family support. These findings suggest that there may not be a shared understanding of the Marie Curie nurse's role, and that equity in community palliative nursing care merits examination. Defining and publicizing the role of the Marie Curie nurse, providing guidance for referrals and prioritizing communication between professionals are proposed not only to enhance the service locally but to ensure that the service is available to all. This article illustrates the value of research to identify ways to improve service delivery.

  4. LONG-TERM ELECTROMAGNETIC FIELD MEASUREMENT AND ASSESSMENT FOR A SHOPPING MALL.

    PubMed

    Engiz, Begum Korunur; Kurnaz, Cetin

    2017-07-01

    As a result of the dense deployment of wireless devices and base stations, measuring and evaluating the electromagnetic (EM) exposure levels they emit have become important to human health especially if they exceed the limits defined in the standards. Base stations, Wi-Fi equipment and other electronic devices are used heavily, especially in densely crowded places like shopping centers. In this study, electric field strength (E) measurements were conducted at one of the largest shopping malls in Turkey. Broadband E measurements were performed using PMM 8053 EM field strength meter for 24 h a day for the duration of one week while frequency selective measurements were carried out with SRM-3006 EM field strength meter. It is concluded from the measurements that the mean measured total E in the band between 100 kHz and 3 GHz is 0.59 V/m while the maximum E is 7.88 V/m, which are both below the limit determined by International Commission on Non-Ionizing Radiation Protection. Evolutions show that E can increase by up to 55% during the daytime. Analyses demonstrate that 71.3% of total E is caused by UMTS2100, 16.3% is produced by GSM900, 6.2% by LTE, 3.5% by Wi-Fi, and 2.7% is generated by devices that use the remaining frequency bands. Based on the detailed statistical analysis of long-term E measurement results, it can be concluded that the measured E levels are not in normal distribution and that they are statistically different with respect to days. Furthermore, distribution of E can be best modeled with the non-parametric approach. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  5. Update on Charcot-Marie-Tooth disease.

    PubMed

    Gutmann, Laurie; Shy, Michael

    2015-10-01

    Charcot-Marie-Tooth disease (CMT) is the common terminology used to describe the hereditary neuropathies. This update reviews advances in the past year in our understanding of these diseases, including some important earlier references. In the past year, advances in next-generation sequencing continued to increase the number of genes associated with CMT. The connection between genotype and phenotype has become more complicated. New insights into the pathogenesis of the diseases are reviewed. Treatment and clinical trial updates coming from these new insights, as well as use of high-throughput screening to match potential treatments with targets, are moving the field forward. There is a discussion of potential next steps, including the use of patient-derived induced pluripotent stem cells, to enhance our understanding of individual genotypes and phenotypes. The use of high-throughput screens, and techniques such as RNAi and induced pluripotent stem cell continue to push forward other therapies for specific genetic forms of CMT and are potentially more generalizable to peripheral neuropathies. These developments, along with the development of improved outcome measures and longitudinal natural history data, advance CMT, making the future for finding treatments and/or cures closer than it has ever been.

  6. [Pathology of Charcot-Marie-Tooth Disease].

    PubMed

    Oka, Nobuyuki

    2016-01-01

    Although genetic testing is available, nerve biopsy is useful in selected patients for the diagnosis of Charcot-Marie-Tooth disease (CMT). These are sporadic cases of hereditary neuropathy, or familial cases in which genetic testing is negative. CMT is caused by mutations of various genes. The pathological features of CMT have mostly been investigated using nerve biopsy, which may shed light on the presumed functions of mutated gene products. PMP22 duplication in CMT1A induces numerous large onion bulb lesions (OB). Compared to chronic inflammatory demyelinating polyradiculoneuropathy, the differential features of CMT1A are patchy distribution of OB and non-inflammatory lesions. CMT1B also manifests as OB, but presents abnormal compaction of myelin sheaths caused by uncompacted myelin or excessive myelin folding. CMT2 includes axonal neuropathies and many causative genes have been found. CMT2A (MFN2 mutation) shows abnormal mitochondria with a spherical morphology instead of tubular in the longitudinal direction. CMT4 consists of autosomal recessive forms with demyelinating pathology. Most subtypes have mutations of genes relating to myelin maintenance, and pathologically, they show abnormal folding of the myelin structure.

  7. Astronaut Mary Ellen Weber with BDS

    NASA Image and Video Library

    1995-08-08

    STS070-301-025 (13-22 July 1995) --- Astronaut Mary Ellen Weber works with a syringe related to the Bioreactor Development System (BDS). The almost weightless state of space travel provides life science researchers with the opportunity to grow cells into three-dimensional tissue pieces that are not achievable using conventional tissue culture methods on Earth. At specified times during the STS-70 mission, crew members injected color producing substances to document fluid movement in the reactor, and various-sized beads to estimate the tissue size that could be supported in the Bioreactor. The photo was among NASA's first release of still photography from the STS-70 mission. The mission was launched from the Kennedy Space Center (KSC) on July 13, 1995, and ended when Discovery landed on Runway 33 there on July 22, 1995. The crew members were astronauts Terence T. (Tom) Henricks, commander; Kevin R. Kregel, pilot; and Donald A. Thomas, Nancy J. Currie and Weber, all mission specialists.

  8. Saint Mary of Nazareth Hospital Center. Chicago, Illinois.

    PubMed

    1985-01-01

    Saint Mary of Nazareth Hospital has been serving the ethnic community on Chicago's near-northwest side since 1894. The city's first Polish hospital, it was founded by the Sisters of the Holy Family of Nazareth to care for many Polish immigrants who settled in the area. Although the surrounding neighborhood is now predominantly comprised of 56% hispanic, 9% black and 37% white ethnic residents, the hospital retains strong ties to the Polish community, as witnessed by a visit to Saint Marys by Cardinal Karol Wojtyla shortly before his election as Pope John Paul II. The hospital's first site was a vacant three-story brick apartment building which the Sisters remodeled into a 24-bed hospital. This facility was quickly outgrown, even after purchase of the two-story frame house next door which increased Saint Marys capacity to 44 beds. Eight years after its founding, a brand new hospital was built. Over the years, Saint Marys continued to experience steady growth requiring the periodic addition of new buildings and wings. By the early 1970s, the need for another brand-new facility was evident. In 1975, a new hospital opened, based on some of the Friesen supply concepts. Today, Saint Marys operates a nearby family practice center, a home health care service, a satellite lab and an intensive care emergency helicopter serving patients in a 120 mile radius.

  9. Auditory function in children with Charcot-Marie-Tooth disease.

    PubMed

    Rance, Gary; Ryan, Monique M; Bayliss, Kristen; Gill, Kathryn; O'Sullivan, Caitlin; Whitechurch, Marny

    2012-05-01

    The peripheral manifestations of the inherited neuropathies are increasingly well characterized, but their effects upon cranial nerve function are not well understood. Hearing loss is recognized in a minority of children with this condition, but has not previously been systemically studied. A clear understanding of the prevalence and degree of auditory difficulties in this population is important as hearing impairment can impact upon speech/language development, social interaction ability and educational progress. The aim of this study was to investigate auditory pathway function, speech perception ability and everyday listening and communication in a group of school-aged children with inherited neuropathies. Twenty-six children with Charcot-Marie-Tooth disease confirmed by genetic testing and physical examination participated. Eighteen had demyelinating neuropathies (Charcot-Marie-Tooth type 1) and eight had the axonal form (Charcot-Marie-Tooth type 2). While each subject had normal or near-normal sound detection, individuals in both disease groups showed electrophysiological evidence of auditory neuropathy with delayed or low amplitude auditory brainstem responses. Auditory perception was also affected, with >60% of subjects with Charcot-Marie-Tooth type 1 and >85% of Charcot-Marie-Tooth type 2 suffering impaired processing of auditory temporal (timing) cues and/or abnormal speech understanding in everyday listening conditions.

  10. Recent advances in Charcot-Marie-Tooth disease.

    PubMed

    Baets, Jonathan; De Jonghe, Peter; Timmerman, Vincent

    2014-10-01

    This article focuses on recent advances in Charcot-Marie-Tooth disease, in particular additions to the genetic spectrum, novel paradigms in molecular techniques and an update on therapeutic strategies. Several new Charcot-Marie-Tooth disease-causing genes have been recently identified, further enlarging the genetic diversity and phenotypic variability, including: SBF1, DHTKD1, TFG, MARS, HARS, HINT1, TRIM1, AIFM1, PDK3 and GNB4. The increasing availability and affordability of next-generation sequencing technologies has ramped up gene discovery and drastically changed genetic screening strategies. All large-scale trials studying the effect of ascorbic acid in Charcot-Marie-Tooth 1A have now been completed and were negative. Efforts have been made to design more robust outcome-measures for clinical trials. Promising results with lonaprisan, curcumin and histone deacetylase 6 inhibitors have been obtained in animal models. Charcot-Marie-Tooth is the most common form of inherited peripheral neuropathy and represents the most prevalent hereditary neuromuscular disorder. The genetic spectrum spans more than 70 genes. Gene discovery has been revolutionized recently by new high-throughput molecular technologies. In addition, the phenotypic diversity has grown tremendously. This is a major challenge for geneticists and neurologists. No effective therapy is available for Charcot-Marie-Tooth. Several large trials with ascorbic acid were negative but research into novel compounds continues.

  11. Soils of Marie Byrd Land, West Antarctica

    NASA Astrophysics Data System (ADS)

    Lupachev, A. V.; Abakumov, E. V.

    2013-10-01

    Soils of Marie Byrd Land-one of the remotest and difficultly accessible regions of Antarctica-were investigated in the area of the mothballed Russkaya station located to the south of 74° S. Despite the extremely severe wind regime (the average wind velocity is 13 m/s, and the maximum wind velocity is up to 60 m/s), the projective cover of vegetation in the area of the station averages 25-40% and reaches 60-80% in some places. The phenomena of physical weathering of the bedrock-exfoliation, stone pavements, residual rocks exposed by wind (hoodoos), and others-are clearly manifested. In most of the described soils, normal organic and organomineral horizons are absent. The soil profiles represent the mixture of the residues of mosses and lichens and the gravelly eluvium. The fine earth material is blown out of the surface horizons by strong winds; its residual accumulation takes place in the middle and lower parts of the profiles. The classification position of these soils is open to argument; they are close to Petrozems and Lithozems. Most of the profiles are underlain by the massive or slightly disintegrated bedrock with dry permafrost at a depth of 20 to 50 cm. Soils with dry permafrost comprise about 75% of the surveyed area. In separate loci in the depressions of the local mesorelief and on gentle slopes, the soils with clearly expressed cryoturbation features are developed; their profiles are underlain by the ice-rich permafrost and compose about 15% of the surveyed area. Anthropogenically disturbed soils and soils polluted with petroleum hydrocarbons, heavy metals, and other pollutants occupy about 10% of the surveyed area.

  12. 78 FR 14653 - Amendment of Class E Airspace; Sault Ste Marie, ON

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-07

    ... control zone over Sault Ste Marie Airport. The FAA is taking this action to enhance the safety and... Airport, Sault Ste Marie, ON, to coincide with that portion of the control zone in Canadian airspace....

  13. 105. Catalog OPark Structure/Construction & Maintenance, 23 Marys Rock Tunnel, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    105. Catalog O-Park Structure/Construction & Maintenance, 23 Marys Rock Tunnel, Negative No. 6306 ca. late 1930s MARYS ROCK TUNNEL, SOUTH PORTAL. - Skyline Drive, From Front Royal, VA to Rockfish Gap, VA , Luray, Page County, VA

  14. 77 FR 25013 - Requested Administrative Waiver of the Coastwise Trade Laws: Vessel MARIE ELENA; Invitation for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-26

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Maritime Administration Requested Administrative Waiver of the Coastwise Trade Laws: Vessel MARIE ELENA... the vessel MARIE ELENA is: Intended Commercial Use of Vessel: ``Sailboat passenger charter...

  15. AmeriFlux US-MRf Mary's River (Fir) site

    DOE Data Explorer

    Law, Bev [Oregon State University

    2016-01-01

    This is the AmeriFlux version of the carbon flux data for the site US-MRf Mary's River (Fir) site. Site Description - The Marys River Fir site is part of the "Synthesis of Remote Sensing and Field Observations to Model and Understand Disturbance and Climate Effects on the Carbon Balance of Oregon and Northern California (ORCA)". Located in the western region of Oregon the Marys River site represents the western extent of the climate gradient that spans eastward into the semi-arid basin of central Oregon. The sites that make up the eastern extent of the ORCA climate gradient is the Metolius site network (US-Me1, US-ME2, US-ME4, US-Me5) all of which are part of the TERRA PNW project at Oregon State University.

  16. MARIE Dose and Flux Measurements in Mars Orbit

    NASA Technical Reports Server (NTRS)

    Zeitlin, C.; Cleghorn, T.; Cucinotta, F. A.; Saganti, P.; Andersen, V.; Lee, K. T.; Pinsky, L. S.; Turner, R.; Atwell, W.

    2004-01-01

    We present results from the Martian Radiation Environment Experiment (MARIE), aboard the 2001 Mars Odyssey spacecraft in orbit around Mars. MARIE operated successfully from March 2002 through October 2003. At the time of this writing, the instrument is off due to a loss of communications during an extremely intense Solar Particle Event. Efforts to revive MARIE are planned for Spring 2004, when Odyssey's role as a communications relay for the MER rovers is completed. During the period of successful operation, MARIE returned the first detailed energetic charged particle data from Mars. Due to limitations of the instrument, normalizing MARIE data to flux or dose is not straightforward - several large corrections are needed. Thus normalized results (like dose or flux) have large uncertainties and/or significant model-dependence. The problems in normalization are mainly due to inefficiency in detecting high-energy protons (signal-to-noise problems force the trigger threshold to be higher than optimal), to the excessively high gains employed in the signal processing electronics (many ions deposit energy sufficient to saturate the electronics, and dE/dx information is lost), and to artifacts associated with the two trigger detectors (incomplete registration of dE/dx). Despite these problems, MARIE is efficient for detecting helium ions with kinetic energies above about 30 MeV/nucleon, and for detecting high-energy ions (energies above about 400 MeV/nucleon) with charges from 5 to 10. Fluxes of these heavier ions can be compared to fluxes obtained from the ACE/CRIS instrument, providing at least one area of direct comparison between data obtained at Earth and at Mars; this analysis will be presented as a work in progress. We will also present dose-rate data, with a detailed explanation of the many sources of uncertainty in normalization. The results for both flux and dose will be compared to predictions of the HZETRN model of the GCR.

  17. MARIE Dose and Flux Measurements in Mars Orbit

    NASA Astrophysics Data System (ADS)

    Zeitlin, C.; Cleghorn, T.; Cucinotta, F.; Saganti, P.; Andersen, V.; Lee, K.; Pinsky, L.; Turner, R.; Atwell, W.

    We present results from the Martian Radiation Environment Experiment (MARIE), aboard the 2001 Mars Odyssey spacecraft in orbit around Mars. MARIE operated successfully from March 2002 through October 2003. At the time of this writing, the instrument is off due to a loss of communications during an extremely intense Solar Particle Event. Efforts to revive MARIE are planned for Spring 2004, when Odyssey's role as a communications relay for the MER rovers is completed. During the period of successful operation, MARIE returned the first detailed energetic charged particle data from Mars. Due to limitations of the instrument, normalizing MARIE data to flux or dose is not straightforward - several large corrections are needed. Thus normalized results (like dose or flux) have large uncertainties and/or significant model-dependence. The problems in normalization are mainly due to inefficiency in detecting high-energy protons (signal-to-noise problems force the trigger threshold to be higher than optimal), to the excessively high gains employed in the signal processing electronics (many ions deposit energy sufficient to saturate the electronics, and dE/dx information is lost), and to artifacts associated with the two trigger detectors (incomplete registration of dE/dx). Despite these problems, MARIE is efficient for detecting helium ions with kinetic energies above about 30 MeV/nucleon, and for detecting high-energy ions (energies above about 400 MeV/nucleon) with charges from 5 to 10. Fluxes of these heavier ions can be compared to fluxes obtained from the ACE/CRIS instrument, providing at least one area of direct comparison between data obtained at Earth and at Mars; this analysis will be presented as a work in progress. We will also present dose-rate data, with a detailed explanation of the many sources of uncertainty in normalization. The results for both flux and dose will be compared to predictions of the HZETRN model of the GCR environment.

  18. 33 CFR 207.441 - St. Marys Falls Canal and Locks, Mich.; security.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false St. Marys Falls Canal and Locks... OF THE ARMY, DEPARTMENT OF DEFENSE NAVIGATION REGULATIONS § 207.441 St. Marys Falls Canal and Locks... the conduct of crew and passengers while transiting St. Marys Falls Canal and Locks and for...

  19. 33 CFR 207.440 - St. Marys Falls Canal and Locks, Mich.; use, administration, and navigation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false St. Marys Falls Canal and Locks.... Marys Falls Canal and Locks, Mich.; use, administration, and navigation. (a) The use, administration... by radiotelephone to the Corps of Engineers Chief Lockmaster at St. Marys Falls Canal dispatch...

  20. 75 FR 51945 - Safety Zone; Potomac River, St. Mary's River, St. Inigoes, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-24

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Potomac River, St. Mary's River, St... establishing a temporary safety zone upon specified waters of the St. Mary's River, a tributary of the Potomac... certain waters of the St. Mary's River, near its confluence with the Potomac River, within a one nautical...

  1. An algorithm for generating an m-ary summation tree

    NASA Technical Reports Server (NTRS)

    Sievers, M.

    1978-01-01

    An algorithm is presented for generating an m-ary summation tree. The algorithm is completely general and may be applied to any length input string. For an N length sequence summed in groups of m sub l at each level l a maximum of 3L - 2 storage is required. A special case of the general m-ary tree where all m sub l are equal is used to smooth data in a radio frequency interference experiment. The maximum storage required when m l sub l = m for all l reduces to the closed form 3 log m N - 2.

  2. ANESTHESIA FOR CHARCOT-MARIE-TOOTH DISEASE: CASE REPORT.

    PubMed

    Alzaben, Khalid R; Samarah, Omar Q; Obeidat, Salameh S; Halhouli, Oday; Al Kharabsheh, Murad

    2016-06-01

    Charcot-Marie-Tooth disease comprises a group of disorders characterized by progressive muscle weakness and wasting. Reviewing the anaesthetic literature produced conflicting reports about the best anaesthetic options for patients with CMTD; as they are at increased risk of prolonged response to muscle relaxants, malignant hyperthermia and risks of regional anaesthesia. We present a case of the successful use of total intravenous anaesthesia with dexmedetomidine and propofol combined with caudal block using bupivacaine mixed with dexmedetomidine without any complications, for a 17 year old male patient with Charcot Marie-Tooth disease who underwent a lower limb orthopedic surgery.

  3. [Charcot-Marie-Tooth disease and bilateral vitritis].

    PubMed

    Anaya-Pava, E J; Cárdenas-Hernández, R I

    2015-04-01

    We describe a patient diagnosed with Charcot-Marie-Tooth disease, with a 4 months history of bilateral decreased visual acuity and floaters. On examination, he had severe bilateral vitreous opacity and sectoral diffuse vascular sheathing. It could not be linked to some underlying aetiology and did not respond to oral steroids. Publications relating to ocular findings in patients with Charcot-Marie-Tooth disease exclude bilateral vitritis. In this case we were unable to test the association with another disease as the cause of vitritis. Copyright © 2013 Sociedad Española de Oftalmología. Published by Elsevier España, S.L.U. All rights reserved.

  4. 77 FR 33094 - Safety Zone; International Bridge 50th Anniversary Celebration Fireworks, St. Mary's River, U.S...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-05

    ... Celebration Fireworks, St. Mary's River, U.S. Army Corps of Engineers Locks, Sault Sainte Marie, MI AGENCY..., Sault Sainte Marie, MI; in the Federal Register (77 FR 21893). We received 1 public submission... Locks, Sault Sainte Marie, MI; in the Federal Register (76 FR 22064). We received 1 public...

  5. Mary Edwards Walker: the soul ahead of her time.

    PubMed

    Rehman, Atiq; Rahman, Naba G; Harris, Sharon M; Cheema, Faisal H

    2015-02-01

    Mary Edwards Walker was a gallant woman who stood for women's rights, embodied the true American spirit, and served the Union Army in the Civil War as a surgeon. She later became the first and only woman in United States history to be awarded the Congressional Medal of Honor.

  6. Mary Petroline Lovato: Courage and Compassion Conquer Cancer.

    ERIC Educational Resources Information Center

    Yuhas, Stephanie

    1998-01-01

    A survivor of leukemia, Mary Lovato has used support groups, fundraising, and workshops to educate Pueblo and other Native people about treatment and management of cancer and has made significant progress in breaking the silence that surrounds the disease among her people. (SAS)

  7. Stirring the Waters: The Influence of Marie Clay.

    ERIC Educational Resources Information Center

    Gaffney, Janet S., Ed.; Askew, Billie J., Ed.

    Celebrating Marie Clay as a major theorist of child literacy acquisition, this book presents 15 essays by distinguished scholars that reflect on her contributions to the field of early literacy; early childhood, bilingual, and special education; developmental, cognitive, and school psychology; assessment; teacher education; professional…

  8. Mary E. Hall: Dawn of the Professional School Librarian

    ERIC Educational Resources Information Center

    Alto, Teresa

    2012-01-01

    A century ago, a woman named Mary E. Hall convinced school leaders of the need for the professional school librarian--a librarian who cultivated a love of reading, academic achievement, and independent learning skills. After graduating from New York City's Pratt Institute Library School in 1895, Hall developed her vision for the high school…

  9. Mary Lyon and Mount Holyoke. Opening the Gates.

    ERIC Educational Resources Information Center

    Green, Elizabeth Alden

    The efforts of Mary Lyon, virtually singlehandedly, to raise money, recruit students, and plan the academic development of Mount Holyoke Female Seminary, founded in 1837, are detailed in this book. The founder sought to educate women through rigorous application of the intellect, which she believed to lead to salvation. In doing so she…

  10. Mary's Story: A Curriculum for Teaching Medical Terminology.

    ERIC Educational Resources Information Center

    Pennsylvania State Univ., University Park. Inst. for the Study of Adult Literacy.

    This packet of materials for a class on medical terminology consists of a collection of stories with highlighted vocabulary, teacher's guide, and student's guide. The materials teach medical terms in a series of stories about a woman named Mary Consola. Each story begins with a list of word parts that will be learned; after the story, new word…

  11. Case Study of a College that Closed: Saint Mary's College

    ERIC Educational Resources Information Center

    Brown, Alice W.

    2011-01-01

    Few colleges choose to close. One that did was Saint Mary's College in Raleigh, North Carolina. Although trustees resisted for a decade, they ultimately made the decision before an anticipated denial of accreditation, allowing the college to control its final days in ways not possible for those who wait until an outside agency forces closure. This…

  12. 6. Photo copy of photograph, (original owned by Mary Gaudineer, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Photo copy of photograph, (original owned by Mary Gaudineer, Beckley, WV, copy at National Forest Office, Elkins, WV), Don Gaudineer, 1934. CONSTRUCTION OF FERNOW EXPERIMENTAL FOREST BUNKHOUSE AND GARAGE. (see also historic photograph WV-237-13) - Parsons Nursery, Fernow Experimental Forest Residence, South side of U.S. Route 219, Parsons, Tucker County, WV

  13. A Day in the Life of Mary Cassatt.

    ERIC Educational Resources Information Center

    Stoppel, Julie

    2002-01-01

    Offers a way to present art history to classroom students where the art teacher pretends to be an artist. Focuses on a lesson where the teacher pretended to be Mary Cassatt. States that the students used pastels when drawing their artwork, in conjunction with the art history lesson. (CMK)

  14. Collection Development Policy: Academic Library, St. Mary's University. Revised.

    ERIC Educational Resources Information Center

    Sylvia, Margaret

    This guide spells out the collection development policy of the library of St. Mary's University in San Antonio, Texas. The guide is divided into the following five topic areas: (1) introduction to the community served, parameters of the collection, cooperation in collection development, and priorities of the collection; (2) considerations in…

  15. 39. Photographic copy of photographs (orignals in possession of Mary ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    39. Photographic copy of photographs (orignals in possession of Mary A. Vreeland), photographer not stated UPPER LEFT AND RIGHT: DINING ROOM AND PARLOR DECORATED FOR CHRISTMAS, CIRCA 1979 LOWER LEFT: VIEW SOUTHEAST, REAR DOOR, CIRCA 1930s LOWER RIGHT: VIEW NORTHWEST, FRONT ELEVATION, CIRCA 1930s - Cadmus House, 159 Fairfield Avenue, West Caldwell, Essex County, NJ

  16. Diaphragm weakness in Charcot-Marie-Tooth disease.

    PubMed Central

    Laroche, C M; Carroll, N; Moxham, J; Stanley, N N; Evans, R J; Green, M

    1988-01-01

    Two patients are described with Charcot-Marie-Tooth disease and chronic peripheral neuropathy. Both had dyspnoea, orthopnoea, and evidence of severe diaphragm weakness. Expiratory muscle function was well preserved and abnormalities of gas exchange during sleep were only minor. PMID:3420560

  17. The "Special" Way: Mary Paxton and Her Journalism Degree.

    ERIC Educational Resources Information Center

    Flocke, Elizabeth Lynne

    The only woman in the first graduating class of the world's first school of journalism at the University of Missouri, Mary Paxton Keeley was offered a position as a special reporter for the "Kansas City Post" in 1910. As was typical for female journalists at the time, most of Paxton's assignments during her 15 months with the…

  18. Response to Mary J. Reichling, "Intersections: Form, Feeling, and Isomorphism"

    ERIC Educational Resources Information Center

    Stevenson, David

    2004-01-01

    David Stevenson's thoughts regarding Reichling's essay are offered in this article, and he begins his response by saying that Mary J. Reichling's essay regarding the three concepts, form, feeling, and isomorphism, is lucid, well structured, and aptly supported by research of other music education philosophers. He points out that Reichling states…

  19. Case Study of a College that Closed: Saint Mary's College

    ERIC Educational Resources Information Center

    Brown, Alice W.

    2011-01-01

    Few colleges choose to close. One that did was Saint Mary's College in Raleigh, North Carolina. Although trustees resisted for a decade, they ultimately made the decision before an anticipated denial of accreditation, allowing the college to control its final days in ways not possible for those who wait until an outside agency forces closure. This…

  20. Mari Belajar Sopan Santun Bahasa Indonesia. [Multimedia Kit

    ERIC Educational Resources Information Center

    DuFon, Margaret A.

    2004-01-01

    Filmed on location in East Java, Indonesia, the Mari Belajar Sopan Santun Bahasa Indonesia set consists of two videotapes, a manual, and extended notes on the individual video scenarios. The videos present interactions among Indonesian native speakers and foreign language learners as they engage in tasks and activities of everyday life. The…

  1. The "Special" Way: Mary Paxton and Her Journalism Degree.

    ERIC Educational Resources Information Center

    Flocke, Elizabeth Lynne

    The only woman in the first graduating class of the world's first school of journalism at the University of Missouri, Mary Paxton Keeley was offered a position as a special reporter for the "Kansas City Post" in 1910. As was typical for female journalists at the time, most of Paxton's assignments during her 15 months with the…

  2. Lift as You Climb: A Profile of President Mary Vosevich

    ERIC Educational Resources Information Center

    Blumenthal, Anita

    2012-01-01

    "My thumb got me into this!" declares the new APPA President Mary Vosevich when asked how she entered the field of educational facilities management. It was 1984, and Vosevich, a Midwest native, was working at Monsanto in St. Louis as a research biologist, having earned her B.S. in horticulture/agriculture from the University of…

  3. Astronaut Mary Ellen Weber during training session in WETF

    NASA Image and Video Library

    1994-05-01

    Attired in a training version of the Extravehicular Mobility Unit (EMU), Astronaut Mary Ellen Weber participates in a training session at JSC's Weightless Environment Training Facility (WETF). Training as a mission specialist for the STS-70 mission, Weber was about to rehearse a contingency space walk. One of several SCUBA-equipped divers waits to assist in the rehearsal in the water.

  4. William and Mary's President Exits on His Own Terms

    ERIC Educational Resources Information Center

    Fain, Paul

    2008-01-01

    The president and governing board at the College of William and Mary have parted ways in an unusually public split with a deeply partisan undercurrent. Gene R. Nichol says that the Board of Visitors forced him out for defending free speech and diversity on the campus, and that he turned down a generous severance package to go quietly. Board…

  5. Lift as You Climb: A Profile of President Mary Vosevich

    ERIC Educational Resources Information Center

    Blumenthal, Anita

    2012-01-01

    "My thumb got me into this!" declares the new APPA President Mary Vosevich when asked how she entered the field of educational facilities management. It was 1984, and Vosevich, a Midwest native, was working at Monsanto in St. Louis as a research biologist, having earned her B.S. in horticulture/agriculture from the University of…

  6. Romanticism or Reality? An Exploration of Frances Mary Hendry's "Chandra."

    ERIC Educational Resources Information Center

    Johnson, Jilaine

    This paper singles out a novel written for children about India, "Chandra" (1995) by Frances Mary Hendry, as a powerful and useful novel to present to today's 11 to 14 year old students. The paper contends that the novel allows students to explore and consider different value systems, challenges them to become aware of prejudice and the…

  7. The Mary Kay Way: The Feminization of a Corporate Discourse.

    ERIC Educational Resources Information Center

    Banks, Jane; Zimmerman, Patricia R.

    1987-01-01

    Investigates the strategies by which corporations adapt to social and cultural change. Argues that the contradiction between the ideology of the nuclear family and women's real needs for economic sustenance and autonomy are separated and deflected into a specific discursive strategy in the operation of Mary Kay Cosmetics. (JD)

  8. The Mary Kay Way: The Feminization of a Corporate Discourse.

    ERIC Educational Resources Information Center

    Banks, Jane; Zimmerman, Patricia R.

    1987-01-01

    Investigates the strategies by which corporations adapt to social and cultural change. Argues that the contradiction between the ideology of the nuclear family and women's real needs for economic sustenance and autonomy are separated and deflected into a specific discursive strategy in the operation of Mary Kay Cosmetics. (JD)

  9. Mary Somerville, mathematician and astronomer of underused talents

    NASA Astrophysics Data System (ADS)

    Bruck, M. T.

    1996-08-01

    Mary Somerville (1780-1872), self-taught mathematician, expert on theoretical astronomy and successful writer, has been described as `the most remarkable woman of her generation'. The publication of her mathematical treatise The Mechanism of the Heavens in 1831, followed by the more popular Connexion of the Physical Sciences in 1834, made her an international celebrity. Her life and work is described.

  10. William and Mary's President Exits on His Own Terms

    ERIC Educational Resources Information Center

    Fain, Paul

    2008-01-01

    The president and governing board at the College of William and Mary have parted ways in an unusually public split with a deeply partisan undercurrent. Gene R. Nichol says that the Board of Visitors forced him out for defending free speech and diversity on the campus, and that he turned down a generous severance package to go quietly. Board…

  11. Astronaut Mary Ellen Weber deploys life raft during bailout training

    NASA Image and Video Library

    1995-02-16

    S95-03501 (16 FEB 1995) --- Astronaut Mary Ellen Weber prepares to deploy a life raft during a training session at the Johnson Space Center's (JSC) Weightless Environment Training Facility (WET-F). Training as a mission specialist for the STS-70 mission, Weber was joined by four crew mates in the emergency bailout rehearsal.

  12. Astronaut Mary Ellen Weber during training session in WETF

    NASA Image and Video Library

    1994-05-01

    Attired in a training version of the Extravehicular Mobility Unit (EMU), astronaut Mary Ellen Weber gets help with the final touches of suit donning during a training session at JSC's Weightless Environment Training Facility (WETF). Training as a mission specialist for the STS-70 mission, Weber was about to rehearse a contingency space walk.

  13. The Rhetoric of Mary Daly: The Rhetoric of Naming.

    ERIC Educational Resources Information Center

    Larson, Suzanne

    As an initial step toward discovering whether a separate genre of women's rhetoric exists, this paper analyzes rhetorical forms used by Mary Daly in the book "Gyn/Ecology." The paper first outlines criteria for determining whether a form has rhetorical significance and traces the historical background of the contemporary feminist…

  14. Missionary Education in Colonial Africa: The Critique of Mary Kingsley.

    ERIC Educational Resources Information Center

    Pearce, Robert

    1988-01-01

    Discussing missionary education in colonial Africa, Pearce examines the ideas of Mary Kingsley, one of the major influences on British thinking towards Africa from the late 1890's. Focusing attention on her educational views, Pearce states that she had influence on all areas of British policy in Africa, and especially West Africa. (GEA)

  15. Measuring Ankle Instability in Pediatric Charcot-Marie-Tooth Disease.

    PubMed

    Mandarakas, Melissa; Hiller, Claire E; Rose, Kristy J; Burns, Joshua

    2013-11-01

    Children with Charcot-Marie-Tooth disease frequently suffer ankle sprain and experience chronic ankle instability; however, no pediatric self-reported measures of chronic ankle instability exist. The aim was to modify and validate the most reliable measure of chronic ankle instability in adults: the Cumberland Ankle Instability Tool. The Cumberland Ankle Instability Tool-Youth was tested for reliability, construct validity, and sensitivity to discriminate between 104 children aged 8 to 16 years: 31 children with Charcot-Marie-Tooth disease, 31 unaffected children with a history of ankle sprains, and 42 controls. Children with Charcot-Marie-Tooth disease had lower scores compared to unaffected children with a history of sprains (χ(2) = 15.10; P < .001) and controls (χ(2) = 33.69; P < .001). Scores moderately correlated to visual analog scale scores of ankle steadiness (r s = 0.684; P < .001), and "good" test-retest reliability was identified (ICC2,1 = 0.73). The Cumberland Ankle Instability Tool-Youth demonstrated excellent sensitivity and construct validity, identifying chronic ankle instability as a common problem for children with Charcot-Marie-Tooth disease.

  16. Mary Petroline Lovato: Courage and Compassion Conquer Cancer.

    ERIC Educational Resources Information Center

    Yuhas, Stephanie

    1998-01-01

    A survivor of leukemia, Mary Lovato has used support groups, fundraising, and workshops to educate Pueblo and other Native people about treatment and management of cancer and has made significant progress in breaking the silence that surrounds the disease among her people. (SAS)

  17. Missionary Education in Colonial Africa: The Critique of Mary Kingsley.

    ERIC Educational Resources Information Center

    Pearce, Robert

    1988-01-01

    Discussing missionary education in colonial Africa, Pearce examines the ideas of Mary Kingsley, one of the major influences on British thinking towards Africa from the late 1890's. Focusing attention on her educational views, Pearce states that she had influence on all areas of British policy in Africa, and especially West Africa. (GEA)

  18. M-ARY POISSON DETECTION AND OPTICAL COMMUNICATIONS.

    DTIC Science & Technology

    noise. When the observables correspond to counts of emitted photoelectrons, the problem models a discrete version of a coherent M-ary optical ... communication system using photon counters in the presence of background radiation. Consideration is given to an average distance and a detection probability

  19. Mary E. Hall: Dawn of the Professional School Librarian

    ERIC Educational Resources Information Center

    Alto, Teresa

    2012-01-01

    A century ago, a woman named Mary E. Hall convinced school leaders of the need for the professional school librarian--a librarian who cultivated a love of reading, academic achievement, and independent learning skills. After graduating from New York City's Pratt Institute Library School in 1895, Hall developed her vision for the high school…

  20. Mari Belajar Sopan Santun Bahasa Indonesia. [Multimedia Kit

    ERIC Educational Resources Information Center

    DuFon, Margaret A.

    2004-01-01

    Filmed on location in East Java, Indonesia, the Mari Belajar Sopan Santun Bahasa Indonesia set consists of two videotapes, a manual, and extended notes on the individual video scenarios. The videos present interactions among Indonesian native speakers and foreign language learners as they engage in tasks and activities of everyday life. The…

  1. Stirring the Waters: The Influence of Marie Clay.

    ERIC Educational Resources Information Center

    Gaffney, Janet S., Ed.; Askew, Billie J., Ed.

    Celebrating Marie Clay as a major theorist of child literacy acquisition, this book presents 15 essays by distinguished scholars that reflect on her contributions to the field of early literacy; early childhood, bilingual, and special education; developmental, cognitive, and school psychology; assessment; teacher education; professional…

  2. Sister Mary Joseph's nodule that originated from lung adenocarcinoma.

    PubMed

    Haruki, Tomohiro; Nakamura, Hiroshige; Kubouchi, Yasuaki; Taniguchi, Yuji; Miwa, Ken; Adachi, Yoshin; Fujioka, Shinji; Ito, Hisao

    2011-03-01

    Umbilical metastasis of cancer, known as Sister Mary Joseph's nodule (SMJN), is a rare phenomenon. It is usually due to intraabdominal malignancies and is quite rare from lung cancer. Here we describe a case of SMJN that originated from advanced lung adenocarcinoma. SMJN should be noted as an important sign of some hidden malignancy including lung cancer.

  3. The Rhetoric of Mary Daly: The Rhetoric of Naming.

    ERIC Educational Resources Information Center

    Larson, Suzanne

    As an initial step toward discovering whether a separate genre of women's rhetoric exists, this paper analyzes rhetorical forms used by Mary Daly in the book "Gyn/Ecology." The paper first outlines criteria for determining whether a form has rhetorical significance and traces the historical background of the contemporary feminist…

  4. 75 FR 23589 - Safety Zones; Blasting Operations and Movement of Explosives, St. Marys River, Sault Sainte Marie...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-04

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zones; Blasting Operations and Movement of... operations and the movement of explosives for those operations. The danger posed by the volume of marine... also require the movement of explosives via barge from Sault Sainte Marie, Michigan to the work site...

  5. 33 CFR 165.T09-0290 - Safety Zones; Blasting Operations and Movement of Explosives, St. Marys River, Sault Sainte Marie...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Safety Zones; Blasting Operations and Movement of Explosives, St. Marys River, Sault Sainte Marie, MI. 165.T09-0290 Section 165.T09-0290 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY REGULATED NAVIGATION AREAS AN...

  6. Overview of environmental and hydrogeologic conditions at Saint Marys, Alaska

    USGS Publications Warehouse

    Nakanishi, Allan S.; Dorava, Joseph M.

    1994-01-01

    The Federal Aviation Administration (FAA) owns or operates airway support facilities near Saint Marys along the Yukon River in west-central Alaska. The FAA is evaluating the severity of environmental contamination and options for remediation of environmental contamination at their facilities. Saint Marys is on a flood plain near the continence of the Yukon and Andreafsky Rivers and has long cold winters and short summers. Residents obtain their drinking water from an infiltration gallery fed by a creek near the village. Surface spills and disposal of hazardous materials combined with potential flooding may affect the quality of the surface and ground water. Alternative drinking-water sources are available, but would likely cost more than existing supplies to develop.

  7. Experimental Physical Sciences Vistas: MaRIE (draft)

    SciTech Connect

    Shlachter, Jack

    2010-09-08

    To achieve breakthrough scientific discoveries in the 21st century, a convergence and integration of world-leading experimental facilities and capabilities with theory, modeling, and simulation is necessary. In this issue of Experimental Physical Sciences Vistas, I am excited to present our plans for Los Alamos National Laboratory's future flagship experimental facility, MaRIE (Matter-Radiation Interactions in Extremes). MaRIE is a facility that will provide transformational understanding of matter in extreme conditions required to reduce or resolve key weapons performance uncertainties, develop the materials needed for advanced energy systems, and transform our ability to create materials by design. Our unique role in materials science starting with the Manhattan Project has positioned us well to develop a contemporary materials strategy pushing the frontiers of controlled functionality - the design and tailoring of a material for the unique demands of a specific application. Controlled functionality requires improvement in understanding of the structure and properties of materials in order to synthesize and process materials with unique characteristics. In the nuclear weapons program today, improving data and models to increase confidence in the stockpile can take years from concept to new knowledge. Our goal with MaRIE is to accelerate this process by enhancing predictive capability - the ability to compute a priori the observables of an experiment or test and pertinent confidence intervals using verified and validated simulation tools. It is a science-based approach that includes the use of advanced experimental tools, theoretical models, and multi-physics codes, simultaneously dealing with multiple aspects of physical operation of a system that are needed to develop an increasingly mature predictive capability. This same approach is needed to accelerate improvements to other systems such as nuclear reactors. MaRIE will be valuable to many national security

  8. Mary Shelley's Frankenstein: what made the Monster monstrous?

    PubMed

    Britton, Ronald

    2015-02-01

    This paper discusses the genesis of the famous story of Frankenstein which arose from a dream experienced by Mary Shelley whilst on a holiday shared with her husband Percy Shelley, Lord Byron, Dr Polidori and her step sister Claire Clairmont. The novel relates how the creature created by Victor Frankenstein horrifies him, is rejected by him and called a monster. The monster's ensuing despair and subsequent murderousness is eloquently described. The whole book is clearly connected to Mary Shelley's experience as an infant whose mother died after giving birth to her and her subsequent loss, as a mother, of her own new born infant. It is suggested that the novel imaginatively describes what it is to have been primarily rejected as an infant and to feel regarded as a monster. © 2015, The Society of Analytical Psychology.

  9. Charcot Marie Tooth disease (CMT): historical perspectives and evolution.

    PubMed

    Kazamel, Mohamed; Boes, Christopher J

    2015-01-01

    Prior to Charcot and Marie's and Tooth's reports, patients with peroneal muscular atrophy had been described by Virchow, Eulenburg, Friedreich, Osler, and others. In February 1886, Charcot and Marie published their original description of five patients who had what they called Progressive Muscular Atrophy. They surmised that the lesion could be in the spinal cord. Three months later, Tooth presented his M.D. degree thesis entitled "Peroneal Type of Progressive Muscular Atrophy", to the University of Cambridge, UK. Tooth localized the pathology to the peripheral nerves. Dyck and Lambert (Arch Neurol 18:619-625, 1968) classified several CMT kinships based on differences in modes of inheritance, natural history, biochemical features, nerve conduction velocity, and pathologic characteristics. This article will focus on historical landmarks and major discoveries pertinent to the disease since its original description through the second half of the twentieth century.

  10. Unilateral opercular infarction presenting with Foix-Chavany-Marie syndrome

    PubMed Central

    Sá, Francisca; Menezes Cordeiro, Inês; Mestre, Susana; Nzwalo, Hipólito

    2014-01-01

    Foix-Chavany-Marie syndrome (FCMS) also known as bilateral anterior opercular syndrome is a form of suprabulbar palsy defined by the presence of bilateral voluntary facial, pharyngeal, lingual and masticatory paralysis with automatic–voluntary movement dissociation. We report an extremely rare case of FCMS in a patient with a unilateral left opercular lesion associated with a chronic asymptomatic contralateral cerebellar lesion. Despite intensive rehabilitation, little improvement was noticed at hospital discharge. PMID:25427932

  11. Jean-Marie Mariotti (1955 - 28 July 1998).

    NASA Astrophysics Data System (ADS)

    Léna, P.

    1998-09-01

    Jean-Marie Mariotti, head of the VLTI programme at ESO since the fall of 1997, passed away at the age of 43 on July 28 in Munich, taken by a sudden and acute leukaemia. Together with his wife, Françoise, and their children, Appolline and Octave (6 and 3 years old), a brief ceremony was held on July 31 at the Ost-Friedhof in Munich, attended by his family and a number of his ESO friends and colleagues.

  12. View of 'Cape St. Mary' from 'Cape Verde' (Altered Contrast)

    NASA Technical Reports Server (NTRS)

    2006-01-01

    As part of its investigation of 'Victoria Crater,' NASA's Mars Exploration Rover Opportunity examined a promontory called 'Cape St. Mary' from the from the vantage point of 'Cape Verde,' the next promontory counterclockwise around the crater's deeply scalloped rim. This view of Cape St. Mary combines several exposures taken by the rover's panoramic camera into an approximately true-color mosaic with contrast adjusted to improve the visibility of details in shaded areas.

    The upper portion of the crater wall contains a jumble of material tossed outward by the impact that excavated the crater. This vertical cross-section through the blanket of ejected material surrounding the crater was exposed by erosion that expanded the crater outward from its original diameter, according to scientists' interpretation of the observations. Below the jumbled material in the upper part of the wall are layers that survive relatively intact from before the crater-causing impact. Near the base of the Cape St. Mary cliff are layers with a pattern called 'crossbedding,' intersecting with each other at angles, rather than parallel to each other. Large-scale crossbedding can result from material being deposited as wind-blown dunes.

    The images combined into this mosaic were taken during the 970th Martian day, or sol, of Opportunity's Mars-surface mission (Oct. 16, 2006). The panoramic camera took them through the camera's 750-nanometer, 530-nanometer and 430-nanometer filters.

  13. The Pasteurization of Marie Curie: A (meta)biographical experiment.

    PubMed

    Wirtén, Eva Hemmungs

    2015-08-01

    Biographies of scientists occupy a liminal space, highly popular with general readers but questioned in academia. Nonetheless, in recent years, historians of science have not only embraced the genre with more enthusiasm and less guilt, they have also turned to the metabiography in order to renew the study and story of scientists' roles. This essay focuses on Marie Curie, the world's most famous female scientist, in order to unpack some of the theoretical and methodological claims of the science biography, and especially to address the sexing mechanisms at play in the construction of the biographical subject. Pierre Curie (1923), Marie's biography of her husband Pierre, paid tribute to her dead husband and collaborator, but also allowed Curie a legitimate outlet to construct her own persona and legacy. Categories such as personhood, person, and persona are not only central to the biography genre but also are essential to the sense of self and self-fashioning of scientists. Looking at how Marie Curie negotiated these categories in Pierre Curie not only gives new insight into Curie's self-fashioning strategies but may also shed some light on the more general analytical lacunae of the science biography.

  14. [The umbilical metastasis. Sister Mary Joseph and her time].

    PubMed

    Trebing, D; Göring, H-D

    2004-02-01

    Although Baluff in 1854 and Nelaton in 1860 had already described umbilical metastases, the best known description of the metastasis of carcinomas to this site as "trouser button navel" was published in 1928 by William James Mayo (1861-1939), son of William Worrall Mayo (1815-1911), the founder of the Mayo Clinic in Rochester, Minnesota, This phenomenon is supposed to have been pointed out to Mayo by his long-serving head surgical nurse Sister Mary Joseph (1856-1939). The English surgeon Hamilton Bailey, in his famous textbook "Physical Signs in Clinical Surgery" in 1949, coined the term "Sister Joseph's nodule" for an umbilical metastasis. The expression has become widely accepted and used. Sister Mary Joseph, daughter of Irish immigrants, belonged to the 3rd order of the Holy Francis, was distinguished for her skills, intelligence and devotion to nursing which was also her calling. She worked for many decades at the world-famous Mayo Clinic and taught generations of young nurses. In recent years, the original surgical building at Saint Mary's Hospital has been named "Joseph Building" in her memory. Among the numerous eponyms occurring in the dermatology and the medicine, the association with the name of a nurse represents beyond doubt a special feature.

  15. A different voice: Mary Hays's the Memoirs of Emma Courtney.

    PubMed

    Sharma, A

    2001-01-01

    Mary Hays wrote in the decade of the 1790s, a period of intense creative flowering in England. Writing in a period enshrined to the works of the canonical Wordsworth and Coleridge, Hays explored through her Jacobinical novel, The Memoirs of Emma Courtney, the contentious relationship between self and society. Like other Jacobin women writers - Elizabeth Inchbald, Charlotte Smith and Mary Wollstonecraft - Mary Hays too used her novel to explode the insidious connection between education and gender construction. Emma Courtney is a landmark novel that wrestles with the paradigm of decorum and propriety which disallows women from voicing their aspirations. In the process, Hays merges the plots of the domestic novel of courtship and love with the novel of ideas to create a searing portrait of women's intellectual confinement and psychic dissonance in a society that only projects them in terms of their gender construction. Memoirs of Emma Courtney is a remarkable novel in its depiction of the emotional imbalance created by thwarted desire: intellectual and sexual.

  16. Stratigraphy, sedimentology, and geothermal reservoir potential of the volcaniclastic Cura-Mallín succession at Lonquimay, Chile

    NASA Astrophysics Data System (ADS)

    Pedroza, Viviana; Le Roux, Jacobus P.; Gutiérrez, Néstor M.; Vicencio, Vladimir E.

    2017-08-01

    The Tolhuaca Volcano near Lonquimay in south-central Chile has been the subject of several studies due to its geothermal manifestations, but little is known about the stratigraphy and reservoir potential of the Cura-Mallín Formation forming its basement. Field work and U-Pb dating of detrital zircons allow us to redefine this succession as the Cura-Mallín Group, consisting of the volcano-sedimentary Guapitrío Formation, sedimentary Río Pedregoso Formation, and volcano-sedimentary Mitrauquén Formation. The Río Pedregoso Formation can be subdivided into three formal units, namely the Quilmahue Member, Rucañanco Member, and Bío-Bío Member. The base of the Quilmahue Member interfingers laterally with the base of the Guapitrío Formation, for which a previous K/Ar date of 22.0 ± 0.9 Ma was apparently discarded by the original authors. However, this date is consistent with the stratigraphic position of the Quilmahue Member and new zircon dates from the overlying units, also coinciding with the initiation of an extensional phase in the Bíobío-Aluminé Basin. Deposition of the Quilmahue Member continued throughout the early Miocene, as confirmed by dates of 17.5 Ma reported by previous authors and 16.5 Ma obtained in this study. The Rucañanco Member was deposited during the Serravalian around 12.6 Ma, whereas the Bío-Bío Member was dated at the Serravalian-Tortonian limit (11.6 Ma). Although all three members were deposited in a fluvio-lacustrine environment, they were dominated respectively by flood plains with crevasse splays, lake margins with distributary mouth bars and Gilbert-type deltas, and distal braided and meandering rivers. Whereas the Quilmahue Member was deposited during basin extension, the Rucañanco Member was formed during a period of basin inversion and compression. Temporary tectonic quiescence during deposition of the Bío-Bío Member allowed denudation of the landscape, but around 9.5 Ma tectonism was renewed again during deposition of

  17. An Analysis of the Symptomatic Domains Most Relevant to Charcot Marie Tooth Neuropathy (CMT) Patients

    ClinicalTrials.gov

    2015-04-28

    Charcot Marie Tooth Disease (CMT); Hereditary Sensory and Motor Neuropathy; Nerve Compression Syndromes; Tooth Diseases; Congenital Abnormalities; Genetic Diseases, Inborn; Heredodegenerative Disorders, Nervous System

  18. Viewing experience of 3DTV: An exploration of the feeling of sickness and presence in a shopping mall

    PubMed Central

    Obrist, Marianna; Wurhofer, Daniela; Meneweger, Thomas; Grill, Thomas; Tscheligi, Manfred

    2013-01-01

    The adoption and deployment of 3DTV can be seen as a major step in the history of television, comparable to the transition from analogue to digital and standard to high definition TV. Although 3D is expected to emerge from the cinema to peoples’ home, there is still a lack of knowledge on how people (future end users) perceive 3DTV and how this influences their viewing experience as well as their acceptance of 3DTV. Within this paper, findings from a three-day field evaluation study on people’s 3DTV experiences, focusing on the feeling of sickness and presence, are presented. Contrary to the traditional controlled laboratory setting, the study was conducted in the public setting of a shopping center and involved 700 participants. The study revealed initial insights on users’ feeling of presence and sickness when watching 3DTV content. Results from this explorative study show that most of the participants reported symptoms of sickness after watching 3DTV with an effect of gender and age on the reported feeling of sickness. Our results further suggest that the users’ previous experience with 3D content has an influence on how realistic people rate the viewing experience and how involved they feel. The particularities of the study environment, a shopping mall, are reflected in our findings and future research directions and action points for investigating people’s viewing experiences of 3DTV are summarized. PMID:23482894

  19. Viewing experience of 3DTV: An exploration of the feeling of sickness and presence in a shopping mall.

    PubMed

    Obrist, Marianna; Wurhofer, Daniela; Meneweger, Thomas; Grill, Thomas; Tscheligi, Manfred

    2013-02-01

    The adoption and deployment of 3DTV can be seen as a major step in the history of television, comparable to the transition from analogue to digital and standard to high definition TV. Although 3D is expected to emerge from the cinema to peoples' home, there is still a lack of knowledge on how people (future end users) perceive 3DTV and how this influences their viewing experience as well as their acceptance of 3DTV. Within this paper, findings from a three-day field evaluation study on people's 3DTV experiences, focusing on the feeling of sickness and presence, are presented. Contrary to the traditional controlled laboratory setting, the study was conducted in the public setting of a shopping center and involved 700 participants. The study revealed initial insights on users' feeling of presence and sickness when watching 3DTV content. Results from this explorative study show that most of the participants reported symptoms of sickness after watching 3DTV with an effect of gender and age on the reported feeling of sickness. Our results further suggest that the users' previous experience with 3D content has an influence on how realistic people rate the viewing experience and how involved they feel. The particularities of the study environment, a shopping mall, are reflected in our findings and future research directions and action points for investigating people's viewing experiences of 3DTV are summarized.

  20. Quantification of aldehyde terminated heparin by SEC-MALLS-UV for the surface functionalization of polycaprolactone biomaterials.

    PubMed

    Irvine, Scott A; Steele, Terry W J; Bhuthalingam, Ramya; Li, Min; Boujday, Souhir; Prawirasatya, Melissa; Neoh, Koon Gee; Boey, Freddy Yin Chiang; Venkatraman, Subbu S

    2015-08-01

    A straight forward strategy of heparin surface grafting employs a terminal reactive-aldehyde group introduced through nitrous acid depolymerization. An advanced method that allows simultaneously monitoring of both heparin molar mass and monomer/aldehyde ratio by size exclusion chromatography, multi-angle laser light scattering and UV-absorbance (SEC-MALLS-UV) has been developed to improve upon heparin surface grafting. Advancements over older methods allow quantitative characterization by direct (aldehyde absorbance) and indirect (Schiff-based absorbance) evaluation of terminal functional aldehydes. The indirect quantitation of functional aldehydes through labeling with aniline (and the formation of a Schiff-base) allows independent quantitation of both polymer mass and terminal functional groups with the applicable UV mass extinction coefficients determined. The protocol was subsequently used to synthesize an optimized heparin-aldehyde that had minimal polydispersity (PDI<2) and high reaction yields (yield >60% by mass). The 8 kDa weight averaged molar mass heparin-aldehyde was then grafted on polycaprolactone (PCL), a common implant material. This optimized heparin-aldehyde retained its antithrombin activity, assessed in freshly drawn blood or surface immobilized on PCL films. Anticoagulant activity was equal to or better than the 24 kDa unmodified heparin it was fragmented from.

  1. STS-70 Mission Specialist Mary Ellen Weber suits up

    NASA Technical Reports Server (NTRS)

    1995-01-01

    A relaxed and smiling STS-70 Mission Specialist Mary Ellen Weber dons her launch/entry suit in the Operations and Checkout Building with help from a suit technician. The 70th Shuttle mission will be Weber's first trip into space. She and four crew mates will depart shortly for Launch Pad 39B, where the Space Shuttle Discovery is undergoing final preparations for a liftoff scheduled during a two and a half hour launch window opening at 9:41 a.m. EDT.

  2. Astronaut Mary Ellen Weber during emergency bailout training at WETF

    NASA Image and Video Library

    1995-02-16

    S95-03469 (16 FEB 1995) --- Attired in a training version of the Shuttle launch and entry garment, astronaut Mary Ellen Weber gets help with the final touches of suit donning during a training session at the Johnson Space Center's (JSC) Weightless Environment Training Facility (WET-F). Helping out is Rockwell's William L. Todd (right), while Staffon Isaacs looks on. Training as a mission specialist for the STS-70 mission, Weber was about to rehearse emergency bailout. The crew members made use of a nearby 25-feet deep pool to practice parachute landings in water and subsequent deployment of life rafts.

  3. 7. Photocopy of photograph (original print in possession of Mary ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Photocopy of photograph (original print in possession of Mary Lane Knott, 508 Central Avenue, Ridgely MD 21660). Photographer and date unknown, Circa 1900. VIEW EAST, SOUTHWEST FRONT, NORTHWEST SIDE Front and side elevations. Note the duplication of the recessed store front with display windows. Note the break in the original clapboard siding toward the rear on the Northwest side and the new clapboard siding near the buggy. Near the buggy wheel an original brick pier. Note the panelling below the display windows and the penny gumball machine on the wall marked 'Adams Tutti-Frutti'. - 510 Central Avenue (Commercial Building), Ridgely, Caroline County, MD

  4. [Ascorbic Acid and Charcot-Marie-Tooth Disease].

    PubMed

    Noto, Yu-ichi

    2015-10-01

    Charcot-Marie-Tooth disease type 1A (CMT1A) is a disease for which no drug treatments are available. Passage et al. reported that ascorbic acid reduced the mRNA level of PMP22, improved motor function and increased the numbers of myelinated peripheral nerve axons in a mouse model of CMT1A. Based on these results, five clinical trials were undertaken at different centers worldwide. However, none of them demonstrated significant effectiveness. Although these outcomes were disappointing, these studies have provided many useful insights for conducting the next randomised controlled trial for CMT1A.

  5. Mary Wakefield: Health Resources and Services Administrator. Interview.

    PubMed

    Wakefield, Mary

    2014-06-01

    Dr. Mary Wakefield is the administrator of the Health Resources and Services Administration. She came from the University of North Dakota, where she directed the Center for Rural Health. She has served as director of the Center for Health Policy, Research and Ethics at George Mason University and has worked with the World Health Organization's Global Programme on AIDS in Geneva, Switzerland. She is a fellow in the American Academy of Nursing and was elected to the Institute of Medicine of the National Academies. A native of North Dakota, Wakefield holds a doctoral degree in nursing from the University of Texas.

  6. Remembering Joan (Jan) Mary Anderson (1932-2015).

    PubMed

    Chow, Wah Soon; Horton, Peter; Barrett, Martin; Osmond, Charles Barry

    2016-08-01

    Joan Mary Anderson, known to most people as Jan, was born on May 12, 1932 in Dunedin, New Zealand. She died on August 28, 2015 in Canberra, Australia. To celebrate her life, we present here a brief biography, some comments on her discoveries in photosynthesis during a career spanning more than half a century, and reminiscences from family and friends. We remember this wonderful person who had an unflagging curiosity, creative ability to think laterally, enthusiasm, passion, generosity and love of color and culture.

  7. Aspects of emic and etic measurement: lessons from Mary Poppins.

    PubMed

    Lee, Christopher J

    2002-01-01

    This article describes emic and etic approaches to measurement in terms of a process of associating indicators and constructs. In this process, it is important to establish evidence of an adequate range of indicators and a relevant association of indicators and constructs and to recognize that such evidence places bounds on the interpretation of measurement outcomes. A passage from one of P. L. Travers's Mary Poppins stories provides a counterpoint for this article's discussion of these key aspects of emic and etic methods of measuring human individuality.

  8. The Mary Ingraham Bunting Institute of Radcliffe College.

    DTIC Science & Technology

    1992-08-31

    AD-A284 034 II~huI~ hI~iRADCLIFFE COLLEGE The Mary Ingraham Bunting Institute Radcliffe Research and Study Center 34 Concord Avenue, Cambridge...time sites for fellows’ work . The ninth fellow was writing her results into a book, and did not need a laboratory affiliation. Accesior For NrTS CRA...stipend, office, and research fund allow them to carry their work in the directions they choose, rather than making them deisndent on the projects

  9. Using the "Mary Tyler Moore Show" as a Feminist Teaching Tool

    ERIC Educational Resources Information Center

    Jule, Allyson

    2010-01-01

    This paper explores the use of "The Mary Tyler Moore Show" as a teaching tool used with a group of final-year undergraduate students who gathered together last academic year (2007-8) to explore Women in Leadership, as part of a Communications course. The research focus was: How can the use of "The Mary Tyler Moore Show" (a…

  10. "Does Broca's Area Exist?:" Christofredo Jakob's 1906 Response to Pierre Marie's Holistic Stance

    ERIC Educational Resources Information Center

    Tsapkini, Kyrana; Vivas, Ana B.; Triarhou, Lazaros C.

    2008-01-01

    In 1906, Pierre Marie triggered a heated controversy and an exchange of articles with Jules Dejerine over the localization of language functions in the human brain. The debate spread internationally. One of the timeliest responses, that appeared in print 1 month after Marie's paper, came from Christofredo Jakob, a Bavarian-born neuropathologist…

  11. Use of FlUKA in the Analysis of the Mars Odyssey MARIE Experiment

    NASA Technical Reports Server (NTRS)

    Pinsky, Lawrence S.; Wilson, Thomas L; Andersen, Victor

    2006-01-01

    UH researchers have significantly improved the calibration of the MARIE by simulating its response to energetic protons using FLUKA. Analysis of MARIE data shows that the intensity of solar energetic particles depends strongly on how well the observation point is connected magnetically to the site at which the particles are accelerated.

  12. Mary Catherine and Me: Building Cross-Cultural Relationships in "Post-Racial" America

    ERIC Educational Resources Information Center

    Bruno, Holly Elissa

    2009-01-01

    In 1963, President Obama's parents could not have married legally in a number of states. Mary Catherine and the author graduated from Corning Free Academy in Corning, New York, in June 1963. The lessons they learned were wrenching: "Someone is going to get hurt." Doors that opened for the author slammed in Mary Catherine's face. Holding Mary…

  13. "The Bravest of the Brave": A Conversation with Mary Bitterman and James Narduzzi

    ERIC Educational Resources Information Center

    Continuing Higher Education Review, 2008

    2008-01-01

    This article presents an interview with Mary Bitterman and James Narduzzi. Mary Bitterman, former President and CEO of The James Irvine Foundation, is President of The Bernard Osher Foundation and Immediate Past Chairman of the Public Broadcasting Service (PBS). James Narduzzi is Dean of the University of Richmond's School of Continuing Studies.…

  14. 33 CFR 161.45 - Vessel Traffic Service St. Marys River.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Vessel Traffic Service St. Marys... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY VESSEL TRAFFIC MANAGEMENT Vessel Traffic Service and Vessel Movement Reporting System Areas and Reporting Points § 161.45 Vessel Traffic Service St. Marys River. (a...

  15. 33 CFR 161.45 - Vessel Traffic Service St. Marys River.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Vessel Traffic Service St. Marys... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY VESSEL TRAFFIC MANAGEMENT Vessel Traffic Service and Vessel Movement Reporting System Areas and Reporting Points § 161.45 Vessel Traffic Service St. Marys River. (a...

  16. 33 CFR 161.45 - Vessel Traffic Service St. Marys River.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Vessel Traffic Service St. Marys... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY VESSEL TRAFFIC MANAGEMENT Vessel Traffic Service and Vessel Movement Reporting System Areas and Reporting Points § 161.45 Vessel Traffic Service St. Marys River. (a...

  17. 33 CFR 161.45 - Vessel Traffic Service St. Marys River.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Vessel Traffic Service St. Marys... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY VESSEL TRAFFIC MANAGEMENT Vessel Traffic Service and Vessel Movement Reporting System Areas and Reporting Points § 161.45 Vessel Traffic Service St. Marys River. (a...

  18. Quality-of-Life in Charcot Marie Tooth Disease: The Patient's Perspective

    PubMed Central

    Johnson, Nicholas E; Heatwole, Chad R; Dilek, Nuran; Sowden, Janet; Kirk, Callyn A; Shereff, Denise; Shy, Michael E; Herrmann, David N

    2014-01-01

    This study determines the impact of symptoms associated with Charcot-Marie-Tooth disease on quality-of-life. Charcot-Marie-Tooth patients in the Inherited Neuropathies Consortium Rare Diseases Clinical Research Network Contact Registry were surveyed. The survey inquired about 214 symptoms and 20 themes previously identified as important to Charcot-Marie-Tooth patients through patient interviews. Symptom population impact was calculated as the prevalence multiplied by the relative importance of each symptom identified. Prevalence and symptom impact were analyzed by age, symptom duration, gender, Charcot-Marie-Tooth type, and employment status. 407 respondents identified foot and ankle weakness (99.7%) and impaired balance (98.6%) as the most prevalent themes. Foot and ankle weakness and limitations with mobility were the themes with the highest impact. Both symptom prevalence and impact gradually increased with age and symptom duration. Several themes were more prevalent in women with Charcot-Marie-Tooth, including activity limitations, pain, fatigue, hip-thigh weakness, and gastrointestinal issues. All of the themes, except emotional or body image issues, were more prevalent among unemployed individuals. There were minimal differences in symptom prevalence between Charcot-Marie-Tooth types. There are multiple symptoms that impact Charcot-Marie-Tooth quality-of-life in adults. These symptoms have different levels of importance, are readily recognized by patients, and represent critical areas of Charcot-Marie-Tooth health. PMID:25092060

  19. Quality-of-life in Charcot-Marie-Tooth disease: the patient's perspective.

    PubMed

    Johnson, Nicholas E; Heatwole, Chad R; Dilek, Nuran; Sowden, Janet; Kirk, Callyn A; Shereff, Denise; Shy, Michael E; Herrmann, David N

    2014-11-01

    This study determines the impact of symptoms associated with Charcot-Marie-Tooth disease on quality-of-life. Charcot-Marie-Tooth patients in the Inherited Neuropathies Consortium Rare Diseases Clinical Research Network Contact Registry were surveyed. The survey inquired about 214 symptoms and 20 themes previously identified as important to Charcot-Marie-Tooth patients through patient interviews. Symptom population impact was calculated as the prevalence multiplied by the relative importance of each symptom identified. Prevalence and symptom impact were analyzed by age, symptom duration, gender, Charcot-Marie-Tooth type, and employment status. 407 participants returned the survey, identifying foot and ankle weakness (99.7%) and impaired balance (98.6%) as the most prevalent themes. Foot and ankle weakness and limitations with mobility were the themes with the highest impact. Both symptom prevalence and impact gradually increased with age and symptom duration. Several themes were more prevalent in women with Charcot-Marie-Tooth, including activity limitations, pain, fatigue, hip-thigh weakness, and gastrointestinal issues. All of the themes, except emotional or body image issues, were more prevalent among unemployed individuals. There were minimal differences in symptom prevalence between Charcot-Marie-Tooth types. There are multiple symptoms that impact Charcot-Marie-Tooth quality-of-life in adults. These symptoms have different levels of importance, are readily recognized by patients, and represent critical areas of Charcot-Marie-Tooth health.

  20. 33 CFR 117.353 - Atlantic Intracoastal Waterway, Savannah River to St. Marys River.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., Savannah River to St. Marys River. 117.353 Section 117.353 Navigation and Navigable Waters COAST GUARD....353 Atlantic Intracoastal Waterway, Savannah River to St. Marys River. (a) General. Public vessels of... Bridge, SR 204, mile 592.9 near Savannah. The draw will open as necessary on the hour from 7 a.m. to 9...

  1. 33 CFR 117.353 - Atlantic Intracoastal Waterway, Savannah River to St. Marys River.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., Savannah River to St. Marys River. 117.353 Section 117.353 Navigation and Navigable Waters COAST GUARD....353 Atlantic Intracoastal Waterway, Savannah River to St. Marys River. (a) General. Public vessels of... Bridge, SR 204, mile 592.9 near Savannah. The draw will open as necessary on the hour from 7 a.m. to 9...

  2. 33 CFR 117.353 - Atlantic Intracoastal Waterway, Savannah River to St. Marys River.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., Savannah River to St. Marys River. 117.353 Section 117.353 Navigation and Navigable Waters COAST GUARD....353 Atlantic Intracoastal Waterway, Savannah River to St. Marys River. (a) General. Public vessels of... Bridge, SR 204, mile 592.9 near Savannah. The draw will open as necessary on the hour from 7 a.m. to 9...

  3. 33 CFR 117.353 - Atlantic Intracoastal Waterway, Savannah River to St. Marys River.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., Savannah River to St. Marys River. 117.353 Section 117.353 Navigation and Navigable Waters COAST GUARD....353 Atlantic Intracoastal Waterway, Savannah River to St. Marys River. (a) General. Public vessels of... Bridge, SR 204, mile 592.9 near Savannah. The draw will open as necessary on the hour from 7 a.m. to 9...

  4. 33 CFR 117.353 - Atlantic Intracoastal Waterway, Savannah River to St. Marys River.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., Savannah River to St. Marys River. 117.353 Section 117.353 Navigation and Navigable Waters COAST GUARD....353 Atlantic Intracoastal Waterway, Savannah River to St. Marys River. (a) General. Public vessels of... Bridge, SR 204, mile 592.9 near Savannah. The draw will open as necessary on the hour from 7 a.m. to 9...

  5. "Does Broca's Area Exist?:" Christofredo Jakob's 1906 Response to Pierre Marie's Holistic Stance

    ERIC Educational Resources Information Center

    Tsapkini, Kyrana; Vivas, Ana B.; Triarhou, Lazaros C.

    2008-01-01

    In 1906, Pierre Marie triggered a heated controversy and an exchange of articles with Jules Dejerine over the localization of language functions in the human brain. The debate spread internationally. One of the timeliest responses, that appeared in print 1 month after Marie's paper, came from Christofredo Jakob, a Bavarian-born neuropathologist…

  6. Potential Hosts for Lambertella corni-maris and Phacidium lacerum within the Family Rosaceae

    USDA-ARS?s Scientific Manuscript database

    Two fungi were described in 2015 and 2016 as pathogens of pome fruit in the Pacific Northwest USA: Lambertella corni-maris on apple (Malus domestica), and Phacidium lacerum (synonym, Ceuthospora pinastri) on apple and d’Anjou pear (Pyrus communis). We documented pathogenicity of L. corni-maris to d...

  7. The Children in the Story: Metafiction in "Mary Poppins in the Park."

    ERIC Educational Resources Information Center

    Didicher, Nicole E.

    1997-01-01

    Reflects on story and storytelling. Uses the "Mary Poppins" series to chart the increasing "literariness" of P.L. Travers' novels, contending that "Mary Poppins in the Park" is the most clearly and consistently metafictional (i.e., self-consciously reflexive). Calls for examining more children's books for how they…

  8. 33 CFR 207.441 - St. Marys Falls Canal and Locks, Mich.; security.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false St. Marys Falls Canal and Locks... OF THE ARMY, DEPARTMENT OF DEFENSE NAVIGATION REGULATIONS § 207.441 St. Marys Falls Canal and Locks... locks in the direction of the approaching tank vessel, unless the tank vessel is certified gas free or...

  9. 33 CFR 207.441 - St. Marys Falls Canal and Locks, Mich.; security.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false St. Marys Falls Canal and Locks... OF THE ARMY, DEPARTMENT OF DEFENSE NAVIGATION REGULATIONS § 207.441 St. Marys Falls Canal and Locks... locks in the direction of the approaching tank vessel, unless the tank vessel is certified gas free or...

  10. Using the "Mary Tyler Moore Show" as a Feminist Teaching Tool

    ERIC Educational Resources Information Center

    Jule, Allyson

    2010-01-01

    This paper explores the use of "The Mary Tyler Moore Show" as a teaching tool used with a group of final-year undergraduate students who gathered together last academic year (2007-8) to explore Women in Leadership, as part of a Communications course. The research focus was: How can the use of "The Mary Tyler Moore Show" (a…

  11. 75 FR 39956 - Certificate of Alternative Compliance for the Offshore Supply Vessel MARIE ELISE

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-13

    ... SECURITY Coast Guard Certificate of Alternative Compliance for the Offshore Supply Vessel MARIE ELISE... Alternative Compliance was issued for the offshore supply vessel MARIE ELISE as required by 33 U.S.C. 1605(c... Title 33, Code of Federal Regulation, Parts 81 and 89, has been issued for the offshore supply...

  12. The Madonna's Reproduction(s): Mieville, Godard, and the Figure of Mary.

    ERIC Educational Resources Information Center

    Erb, Cynthia

    1993-01-01

    Discusses how an assessment of "Le Livre de Marie" and "Je Vous Salue, Marie" risks reproducing the feminine/masculine dynamic by posing the films as male and female versions of the Marian myth. Acknowledges that evidence for this dichotomy exists, but both directors succeed in activating the Marian myth in ways that do not…

  13. 33 CFR 165.731 - Safety/Security Zone: Cumberland Sound, Georgia and St. Marys River Entrance Channel.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Sound, Georgia and St. Marys River Entrance Channel. 165.731 Section 165.731 Navigation and Navigable... Seventh Coast Guard District § 165.731 Safety/Security Zone: Cumberland Sound, Georgia and St. Marys River... waters and land from bank to bank within Cumberland Sound and the St. Marys Entrance Channel:...

  14. 33 CFR 165.731 - Safety/Security Zone: Cumberland Sound, Georgia and St. Marys River Entrance Channel.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Sound, Georgia and St. Marys River Entrance Channel. 165.731 Section 165.731 Navigation and Navigable... Seventh Coast Guard District § 165.731 Safety/Security Zone: Cumberland Sound, Georgia and St. Marys River... waters and land from bank to bank within Cumberland Sound and the St. Marys Entrance Channel:...

  15. 33 CFR 165.731 - Safety/Security Zone: Cumberland Sound, Georgia and St. Marys River Entrance Channel.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Sound, Georgia and St. Marys River Entrance Channel. 165.731 Section 165.731 Navigation and Navigable... Seventh Coast Guard District § 165.731 Safety/Security Zone: Cumberland Sound, Georgia and St. Marys River... waters and land from bank to bank within Cumberland Sound and the St. Marys Entrance Channel:...

  16. 33 CFR 165.731 - Safety/Security Zone: Cumberland Sound, Georgia and St. Marys River Entrance Channel.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Sound, Georgia and St. Marys River Entrance Channel. 165.731 Section 165.731 Navigation and Navigable... Seventh Coast Guard District § 165.731 Safety/Security Zone: Cumberland Sound, Georgia and St. Marys River... waters and land from bank to bank within Cumberland Sound and the St. Marys Entrance Channel:...

  17. Antoni Quintana-Mari (1907-1998): A Pioneer of the Use of History of Science in Science Education

    ERIC Educational Resources Information Center

    Roca-Rosell, Antoni; Grapi-Vilumara, Pere

    2010-01-01

    In the early 1930s, the young Antoni Quintana-Mari undertook some research on Antoni de Marti i Franques, one of the most prominent Catalan scientists of the Enlightenment. This scientist worked in Tarragona, where Quintana-Mari lived. Quintana-Mari learnt about Marti i Franques from Josep Estalella, his teacher of physics and chemistry at the…

  18. A space radiation shielding model of the Martian radiation environment experiment (MARIE)

    NASA Technical Reports Server (NTRS)

    Atwell, W.; Saganti, P.; Cucinotta, F. A.; Zeitlin, C. J.

    2004-01-01

    The 2001 Mars Odyssey spacecraft was launched towards Mars on April 7, 2001. Onboard the spacecraft is the Martian radiation environment experiment (MARIE), which is designed to measure the background radiation environment due to galactic cosmic rays (GCR) and solar protons in the 20-500 MeV/n energy range. We present an approach for developing a space radiation-shielding model of the spacecraft that includes the MARIE instrument in the current mapping phase orientation. A discussion is presented describing the development and methodology used to construct the shielding model. For a given GCR model environment, using the current MARIE shielding model and the high-energy particle transport codes, dose rate values are compared with MARIE measurements during the early mapping phase in Mars orbit. The results show good agreement between the model calculations and the MARIE measurements as presented for the March 2002 dataset. c2003 COSPAR. Published by Elsevier Ltd. All rights reserved.

  19. A space radiation shielding model of the Martian radiation environment experiment (MARIE)

    NASA Technical Reports Server (NTRS)

    Atwell, W.; Saganti, P.; Cucinotta, F. A.; Zeitlin, C. J.

    2004-01-01

    The 2001 Mars Odyssey spacecraft was launched towards Mars on April 7, 2001. Onboard the spacecraft is the Martian radiation environment experiment (MARIE), which is designed to measure the background radiation environment due to galactic cosmic rays (GCR) and solar protons in the 20-500 MeV/n energy range. We present an approach for developing a space radiation-shielding model of the spacecraft that includes the MARIE instrument in the current mapping phase orientation. A discussion is presented describing the development and methodology used to construct the shielding model. For a given GCR model environment, using the current MARIE shielding model and the high-energy particle transport codes, dose rate values are compared with MARIE measurements during the early mapping phase in Mars orbit. The results show good agreement between the model calculations and the MARIE measurements as presented for the March 2002 dataset. c2003 COSPAR. Published by Elsevier Ltd. All rights reserved.

  20. A space radiation shielding model of the Martian radiation environment experiment (MARIE).

    PubMed

    Atwell, W; Saganti, P; Cucinotta, F A; Zeitlin, C J

    2004-01-01

    The 2001 Mars Odyssey spacecraft was launched towards Mars on April 7, 2001. Onboard the spacecraft is the Martian radiation environment experiment (MARIE), which is designed to measure the background radiation environment due to galactic cosmic rays (GCR) and solar protons in the 20-500 MeV/n energy range. We present an approach for developing a space radiation-shielding model of the spacecraft that includes the MARIE instrument in the current mapping phase orientation. A discussion is presented describing the development and methodology used to construct the shielding model. For a given GCR model environment, using the current MARIE shielding model and the high-energy particle transport codes, dose rate values are compared with MARIE measurements during the early mapping phase in Mars orbit. The results show good agreement between the model calculations and the MARIE measurements as presented for the March 2002 dataset.

  1. Marie Bonaparte, her first two patients and the literary world.

    PubMed

    Amouroux, Rémy

    2010-08-01

    Marie Bonaparte (1882-1962) played a critical role in the development of psychoanalysis in France. Her clinical activity is not well known yet she was one of the first female French psychoanalysts. The journalist-writers Alice and Valerio Jahier were Bonaparte's first two patients. She conducted this dual analysis with Rudolph Loewenstein (1898-1976). Alice and Valerio exchanged analysts on several occasions. During his analysis, Valerio began corresponding with Italo Svevo (1861-1928), the author of La Coscienza di Zeno, who imparted his doubts on the therapeutic merits of psychoanalysis. Valerio described his difficult analysis in his letters to Svevo. Bonaparte consulted Freud on the subject, but was not able to prevent Valerio's suicide in 1939. The Princess of Greece encouraged Alice in her vocation as a writer and enabled her to benefit from her connections in literary circles. On the margins of this unpublished story of the two analyses, which is based on archived documents recently made available, we discover the importance of the links which were formed - around Marie Bonaparte - between psychoanalysis and literature. In addition to Italo Svevo, we come across the acerbic writer, Maurice Sachs, as well as the famous novelist, Stefan Zweig. Copyright © 2010 Institute of Psychoanalysis.

  2. Mary, a Pipeline to Aid Discovery of Optical Transients

    NASA Astrophysics Data System (ADS)

    Andreoni, I.; Jacobs, C.; Hegarty, S.; Pritchard, T.; Cooke, J.; Ryder, S.

    2017-09-01

    The ability to quickly detect transient sources in optical images and trigger multi-wavelength follow up is key for the discovery of fast transients. These include events rare and difficult to detect such as kilonovae, supernova shock breakout, and `orphan' Gamma-ray Burst afterglows. We present the Mary pipeline, a (mostly) automated tool to discover transients during high-cadenced observations with the Dark Energy Camera at Cerro Tololo Inter-American Observatory (CTIO). The observations are part of the `Deeper Wider Faster' programme, a multi-facility, multi-wavelength programme designed to discover fast transients, including counterparts to Fast Radio Bursts and gravitational waves. Our tests of the Mary pipeline on Dark Energy Camera images return a false positive rate of 2.2% and a missed fraction of 3.4% obtained in less than 2 min, which proves the pipeline to be suitable for rapid and high-quality transient searches. The pipeline can be adapted to search for transients in data obtained with imagers other than Dark Energy Camera.

  3. Twitter in the Cross Fire—The Use of Social Media in the Westgate Mall Terror Attack in Kenya

    PubMed Central

    Simon, Tomer; Goldberg, Avishay; Aharonson-Daniel, Limor; Leykin, Dmitry; Adini, Bruria

    2014-01-01

    On September 2013 an attack on the Westgate mall in Kenya led to a four day siege, resulting in 67 fatalities and 175 wounded. During the crisis, Twitter became a crucial channel of communication between the government, emergency responders and the public, facilitating the emergency management of the event. The objectives of this paper are to present the main activities, use patterns and lessons learned from the use of the social media in the crisis. Using TwitterMate, a system developed to collect, store and analyze tweets, the main hashtags generated by the crowd and specific Twitter accounts of individuals, emergency responders and NGOs, were followed throughout the four day siege. A total of 67,849 tweets were collected and analyzed. Four main categories of hashtags were identified: geographical locations, terror attack, social support and organizations. The abundance of Twitter accounts providing official information made it difficult to synchronize and follow the flow of information. Many organizations posted simultaneously, by their manager and by the organization itself. Creating situational awareness was facilitated by information tweeted by the public. Threat assessment was updated through the information posted on social media. Security breaches led to the relay of sensitive data. At times, misinformation was only corrected after two days. Social media offer an accessible, widely available means for a bi-directional flow of information between the public and the authorities. In the crisis, all emergency responders used and leveraged social media networks for communicating both with the public and among themselves. A standard operating procedure should be developed to enable multiple responders to monitor, synchronize and integrate their social media feeds during emergencies. This will lead to better utilization and optimization of social media resources during crises, providing clear guidelines for communications and a hierarchy for dispersing

  4. Twitter in the cross fire--the use of social media in the Westgate Mall terror attack in Kenya.

    PubMed

    Simon, Tomer; Goldberg, Avishay; Aharonson-Daniel, Limor; Leykin, Dmitry; Adini, Bruria

    2014-01-01

    On September 2013 an attack on the Westgate mall in Kenya led to a four day siege, resulting in 67 fatalities and 175 wounded. During the crisis, Twitter became a crucial channel of communication between the government, emergency responders and the public, facilitating the emergency management of the event. The objectives of this paper are to present the main activities, use patterns and lessons learned from the use of the social media in the crisis. Using TwitterMate, a system developed to collect, store and analyze tweets, the main hashtags generated by the crowd and specific Twitter accounts of individuals, emergency responders and NGOs, were followed throughout the four day siege. A total of 67,849 tweets were collected and analyzed. Four main categories of hashtags were identified: geographical locations, terror attack, social support and organizations. The abundance of Twitter accounts providing official information made it difficult to synchronize and follow the flow of information. Many organizations posted simultaneously, by their manager and by the organization itself. Creating situational awareness was facilitated by information tweeted by the public. Threat assessment was updated through the information posted on social media. Security breaches led to the relay of sensitive data. At times, misinformation was only corrected after two days. Social media offer an accessible, widely available means for a bi-directional flow of information between the public and the authorities. In the crisis, all emergency responders used and leveraged social media networks for communicating both with the public and among themselves. A standard operating procedure should be developed to enable multiple responders to monitor, synchronize and integrate their social media feeds during emergencies. This will lead to better utilization and optimization of social media resources during crises, providing clear guidelines for communications and a hierarchy for dispersing

  5. [The prevalence of irritable bowel symptoms in a population of shopping mall visitors in Santiago de Chile].

    PubMed

    Madrid-Silva, A M; Defilippi-Caffri, C; Landskron-Ramos, G; Olguín-Herrera, F; Reyes-Ponce, A; Castro-Lara, A; Larraín-Corp, S; Martínez-Roje, N; Cortés-Espinoza, J

    2013-01-01

    Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by abdominal pain or discomfort that is associated with altered bowel habit. Both its prevalence and clinical characteristics vary throughout Latin America. A percentage of patients does not seek medical attention, therefore a reliable prevalence figure can only be established by interviewing non-selected populations. To study the prevalence and clinical characteristics of IBS symptoms in non-selected subjects in Santiago, Chile. A total of 437 shopping mall visitors above the age of 15 years (246 women) participated in the study by answering the Rome II validated questionnaire for IBS. The demographic and socioeconomic backgrounds, comorbidities, and a family history of IBS were registered. A total of 64.1% subjects reported having gastrointestinal symptoms and 28.6% had symptoms suggestive of IBS. When the subjects with IBS symptoms were compared with the asymptomatic individuals, a predominance of women (65.6 vs. 42.9, P<.001) and a greater cholecystectomy frequency (33.6 vs. 12.9% P<.05) were observed in the former. The age of symptom onset was 30.4 years. An equal percentage of subjects (42.4%) presented with diarrhea and constipation and 15.2% presented with alternating IBS. Participants with a higher educational level reported a lower percentage of IBS (P<.05). A family history of the disease was present in 40% of the subjects with IBS, compared with 14.9% in the asymptomatic individuals (P<.05). Only 39.2% of the subjects had seen a physician for their symptoms and the treatment and tests ordered were inappropriate. The prevalence of IBS symptoms in the population studied is one of the highest described. Therefore, health teams should have the necessary knowledge and skill required for its management. Copyright © 2013 Asociación Mexicana de Gastroenterología. Published by Masson Doyma México S.A. All rights reserved.

  6. Chronologic implications of new Miocene mammals from the Cura-Mallín and Trapa Trapa formations, Laguna del Laja area, south central Chile

    NASA Astrophysics Data System (ADS)

    Flynn, John J.; Charrier, Reynaldo; Croft, Darin A.; Gans, Phillip B.; Herriott, Trystan M.; Wertheim, Jill A.; Wyss, André R.

    2008-12-01

    Recent work in the central Andean Main Range of Chile near Laguna del Laja (˜37.5°S, 71°W) has produced the first mammal fossils for the region. Fossils, locally abundant and well preserved, occur patchily across a wide area southeast of the lake. Mammalian remains are derived from generally strongly folded (kilometer-scale) exposures of the locally ˜1.8 km thick, early to middle Miocene Cura-Mallín Formation; two identifiable specimens have been recovered from the overlying Trapa Trapa Formation as well. Both formations consist primarily of well-stratified (1-5 m thick layers) volcaniclastic and volcanic strata, deposited predominantly in fluviatile systems. The Cura-Mallín Formation is possibly the southern continuation of (or lateral equivalent to) the richly fossiliferous Abanico Formation mapped between ˜32°S and 36°S. Intensive sampling in a series of localities east and south of Laguna del Laja has yielded diverse faunas, in addition to radioisotopically dateable horizons. The new fossil mammal faunas represent as many as six South American Land Mammal "Ages" (SALMAs). Fossils, together with preliminary 40Ar/ 39Ar radioisotopic dates, ranging from ˜9 to 20 Ma across the exposed thickness of the Cura-Mallín Formation and into the overlying Trapa Trapa Formation, provide a robust geochronological framework for middle Cenozoic strata in the Laguna del Laja region. The sequence of directly superposed mammalian assemblages at Laguna del Laja is one of the longest in all of South America, rivaled only by the classic Gran Barranca section of Patagonian Argentina. These data illuminate the geological history of the area and its record of mammalian evolution. The potential to isotopically date these diverse faunas with high precision (error ± 0.5 Ma) presents a rare opportunity to calibrate related portions of the SALMA sequence.

  7. "Inhumanly brought back to life and misery": Mary Wollstonecraft, Frankenstein, and the Royal Humane Society.

    PubMed

    Williams, C

    2001-01-01

    While thorough investigation of many aspects of contemporary scientific developments and Mary Shelley's personal history have provided illuminating contexts for the study of Frankenstein, the activities of the Royal Humane Society, and other bodies and individuals who pioneered and publicized resuscitation techniques, have been comparatively neglected. Here we find a richly documented, highly conspicuous area of scientific endeavour, which generated much excitement in life and literature from the last quarter of the eighteenth century onwards. There are three major points of contact with Frankenstein: Victor Frankenstein's revival of dead tissue to make his creature; the frequent occurrences of unconsciousness and asphyxia, both in the novel and in Mary Shelley's family during the period leading up to its composition, and the widely differing degrees of competence and success with which they are treated; and the possibility that resuscitative techniques were used to revive Mary Shelley's mother, Mary Wollstonecraft, after a suicide attempt. The impact on Frankenstein of Mary Shelley's lifelong distress at the role she played in bringing about her mother's death in childbirth has been thoroughly canvassed by other critics, notably Anne Mellor, but the thought that Mary Shelley, who was herself conceived after her mother's second suicide attempt, might be, in a sense, a child of the dead adds a further turn to the Gothic screw. This study traces a hitherto unexplored intersection between Mary Shelley's first novel and her family history, as well as showing how it launches a formidable attack on the shady ethics and inconsiderate arrogance of some early resuscitators.

  8. MaRIE: an experimental facility concept revolutionizing materials in extremes

    SciTech Connect

    Barnes, Cris W

    2011-01-07

    The Matter-Radiation Interactions in Extremes (MaRIE) project intends to create an experimental facility that will revolutionize the control of materials in extremes. That control extends to extreme regimes where solid material has failed and begins to flow - the regimes of fluid dynamics and turbulent mixing. This presentation introduces the MaRIE facility concept, demonstrates examples of the science case that determine its functional requirements, and kicks-off the discussion of the decadal scientific challenges of mixing in extremes, including those MaRIE might address.

  9. St. Mary cooks up awareness with heart-healthy booklet, television.

    PubMed

    Botvin, Judith D

    2003-01-01

    St. Mary Medical Center, Langhorne, Pa., distributed a half-million copies of its copyrighted booklet, "Heart Healthy Living" as the first of a larger, long-term marketing initiative to raise awareness of the suburban medical center. In addition to the medical center and physicians' offices, St. Mary had the booklet distributed by regional food markets and Fleet Bank. These partnerships and those with food products manufacturers helped reduce expenses. St. Mary physicians appeared on a cable television cooking show as well as in selected grocery markets.

  10. MaRIE: Probing Dynamic Processes in Soft Materials Using Advanced Light Sources

    SciTech Connect

    Sykora, Milan; Kober, Edward Martin

    2016-02-16

    Los Alamos National Laboratory has developed a concept for a new research facility, MaRIE: Matter-Radiation Interactions in Extremes. The key motivation for MaRIE is to develop new experimental capabilities needed to fill the existing gaps in our fundamental understanding of materials important for key National Nuclear Security Agency (NNSA) goals. MaRIE will bring two major new capabilities: (a) the ability to characterize the meso- and microstructure of materials in bulk as well as local dynamic response characteristics, and (b) the ability to characterize how this microstructure evolves under NNSA-relevant conditions and impacts the material’s performance in this regime.

  11. Noncompaction Cardiomyopathy with Charcot-Marie-Tooth Disease.

    PubMed

    Eltawansy, Sherif Ali; Bakos, Andrea; Checton, John

    2015-01-01

    We report a case of a 53-year-old female presenting with a new-onset heart failure that was contributed secondary to noncompaction cardiomyopathy. The diagnosis was made by echocardiogram and confirmed by cardiac MRI. Noncompaction cardiomyopathy (also known as ventricular hypertrabeculation) is a newly discovered disease. It is considered to be congenital (genetic) cardiomyopathy. It is usually associated with genetic disorders and that could explain the genetic pathogenesis of the non-compaction cardiomyopathy. Our case had a history of Charcot-Marie-Tooth disease. There is a high incidence of arrhythmia and embolic complications. The treatment usually consists of the medical management, defibrillator placement, and lifelong anticoagulation. Heart transplantation will be the last resort.

  12. Therapeutic options in Charcot-Marie-Tooth diseases.

    PubMed

    Mathis, Stéphane; Magy, Laurent; Vallat, Jean-Michel

    2015-04-01

    Charcot-Marie-Tooth (CMT) diseases represent a heterogeneous genetic disorder (more than 80 genes are implicated in these inherited neuropathies), but sharing a similar phenotype. In recent years, advances in molecular genetics and molecular biology, and also the development of various animal models of CMT, have led to a better understanding. Taken together, this knowledge represents a prerequisite for the development of future therapies in CMT, and in peripheral nervous system disorders in general. The efficacy of various substances has been shown in vitro and also in vivo (in animal models); but, no significant positive effect has yet been confirmed in humans. However, some of these trials are still in development, and we may expect positive results in the future. Although CMT is still an incurable disease, symptomatic treatments (physiotherapy, surgery, analgesic, etc.) are crucial to improve the quality of life of CMT patients.

  13. Unilateral opercular infarction presenting with Foix-Chavany-Marie Syndrome.

    PubMed

    Ohtomo, Ryo; Iwata, Atsushi; Tsuji, Shoji

    2014-01-01

    A 76-year-old man with a history of pontine, cerebellar infaction suddenly became speechless during the procedure of percutaneous coronary intervention. On examination, he was unable to close his mouth voluntarily, but spontaneous closing was preserved when smiling. He had anarthria and hypophonia, although his comprehension was preserved. He also had a severe dysphagia. Radiological studies revealed an acute stroke in the left anterior operculum, indicating Foix-Chavany-Marie Syndrome (FCMS) caused by a unilateral opercular lesion. Pathophysiology of the previous cases reported as unilateral FCMS remains controversial, but in our case, it could be delineated by the combination of the new lesion in the unilateral operculum and the old one in the contralateral pons. Since FCMS is not only related to biopercular lesions, we should consider thorough radiologic examination to clarify its anatomic basis.

  14. Bandwidth efficient block codes for M-ary PSK modulation

    NASA Technical Reports Server (NTRS)

    Lin, Shu

    1987-01-01

    A class of bandwidth efficient block codes for M-ary PSK modulation is presented. A soft-decision decoding for this class of codes is devised. Some specific short codes for Quad Phase Shift Key (QPSK), 8-PSK and 16-PSK modulations are constructed. These codes have good minimum squared Euclidean distances and provide 2 to 5.8 dB coding gains over uncoded QPSK modulation without (or with little) bandwidth expansion. The complete weight distributions of these specific codes are determined. Based on these weight distributions, their error probabilities are evaluated. Some of these codes have simple trellis structures and hence can be decoded by Viterbi decoding algorithm with relatively simple implementation. Moreover, the codes are very suitable for use as inner codes for various cascaded coding schemes with Reed-Solomon codes as outer codes.

  15. The lives of Mary Foote: painter and Jungian.

    PubMed

    Trousdell, Richard

    2016-11-01

    Mary Foote (1872-1968) was a successful early twentieth century American artist who suddenly closed her New York studio in 1926 to go to Zurich to study with Jung. There she joined his 'Interpretation of Visions' seminars (1930-1934), which she recorded and edited. This work won Jung's praise and his friendship, but all too often Foote was seen merely as a secretary or background figure. Deirdre Bair's biography of Jung suggested that Foote's life and work deserved fuller study, if only to rebalance our view of Jung's early women followers. This paper takes up that work to ask how Foote's early life and career led to her important work in preserving and describing Jung's earliest attempts to apply his theories to clinical practice. © 2016, The Society of Analytical Psychology.

  16. Florence Nightingale and Mary Seacole on nursing and health care.

    PubMed

    McDonald, Lynn

    2014-06-01

    The purpose of this article is to correct inaccurate information about both Mary Seacole and Florence Nightingale, material that promotes Seacole as a pioneer nurse and heroine, while either ignoring Nightingale or trivializing her contribution. Nursing journals have been prominent in promoting inaccurate accounts of the contribution of Seacole to nursing. Some have intermittently published positive material about Nightingale, but none has published redress. Discussion paper. Primary sources from 1855-2012 were found, which contradict some key claims made about Seacole. Further sources - not included here - are identified, with a website reference. It is argued that Nightingale remains relevant as a model for nurses, with the many crises in patient care and continuing challenges of hospital safety. Greater accuracy and honesty are required in reporting about nursing heroes. Without these, great ideas and examples can be lost to nursing and health care. © 2013 John Wiley & Sons Ltd.

  17. Sister Mary Joseph's nodule as initial pancreatic cancer manifestation.

    PubMed

    Vallejo Bernad, Cristina; Casamayor Franco, María Carmen; Hakim Alonso, Sofía

    2017-02-01

    We report the case of an 85-year-old female patient who presented with umbilical pain associated with an indurated growth, the whole being apparently consistent with incarcerated umbilical hernia, which prompted an urgent surgical procedure for its removal. The pathology study revealed dermal infiltration by a malignancy. Gland tumor cells expressed an immunohistochemical profile initially consistent with a pancreatic origin. In view of these findings a CT scan was performed, which revealed a pancreatic tail tumor as well as multiple hepatic metastasis. Skin metastasis is a rare sign usually reflecting a carcinoma of unknown origin. Umbilical skin metastasis, called Sister Mary Joseph´s nodule, reflect an intra-abdominal tumor, being pancreatic cancer strange.

  18. Indoor air quality (IAQ) assessment in a multistorey shopping mall by high-spatial-resolution monitoring of volatile organic compounds (VOC).

    PubMed

    Amodio, M; Dambruoso, P R; de Gennaro, Gianluigi; de Gennaro, L; Loiotile, A Demarinis; Marzocca, A; Stasi, F; Trizio, L; Tutino, M

    2014-12-01

    In order to assess indoor air quality (IAQ), two 1-week monitoring campaigns of volatile organic compounds (VOC) were performed in different areas of a multistorey shopping mall. High-spatial-resolution monitoring was conducted at 32 indoor sites located in two storehouses and in different departments of a supermarket. At the same time, VOC concentrations were monitored in the mall and parking lot area as well as outdoors. VOC were sampled at 48-h periods using diffusive samplers suitable for thermal desorption. The samples were then analyzed with gas chromatography-mass spectrometry (GC-MS). The data analysis and chromatic maps indicated that the two storehouses had the highest VOC concentrations consisting principally of terpenes. These higher TVOC concentrations could be a result of the low efficiency of the air exchange and intake systems, as well as the large quantity of articles stored in these small spaces. Instead, inside the supermarket, the food department was the most critical area for VOC concentrations. To identify potential emission sources in this department, a continuous VOC analyzer was used. The findings indicated that the highest total VOC concentrations were present during cleaning activities and that these activities were carried out frequently in the food department. The study highlights the importance of conducting both high-spatial-resolution monitoring and high-temporal-resolution monitoring. The former was able to identify critical issues in environments with a complex emission scenario while the latter was useful in interpreting the dynamics of each emission source.

  19. Mediated Career Education at the Marie H. Katzenbach School for the Deaf

    ERIC Educational Resources Information Center

    Lenox, James; Hamilton, Ronald

    1973-01-01

    A comprehensive career education program which uses varieties of audiovisual aids for aurally handicapped students, 4 through 21 years of age, at the Marie H. Katzenbach School for the Deaf is described. (MC)

  20. 77 FR 49719 - Amendment of Class D Airspace; Sault Ste Marie, ON

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-17

    ... control zone over Sault Ste Marie Airport. The FAA is taking this action to enhance the safety and..., creating additional controlled airspace to coincide with that portion of the control zone in...

  1. A m-ary linear feedback shift register with binary logic

    NASA Technical Reports Server (NTRS)

    Perlman, M. (Inventor)

    1973-01-01

    A family of m-ary linear feedback shift registers with binary logic is disclosed. Each m-ary linear feedback shift register with binary logic generates a binary representation of a nonbinary recurring sequence, producible with a m-ary linear feedback shift register without binary logic in which m is greater than 2. The state table of a m-ary linear feedback shift register without binary logic, utilizing sum modulo m feedback, is first tubulated for a given initial state. The entries in the state table are coded in binary and the binary entries are used to set the initial states of the stages of a plurality of binary shift registers. A single feedback logic unit is employed which provides a separate feedback binary digit to each binary register as a function of the states of corresponding stages of the binary registers.

  2. Old Houses and Old Women: An Approach to Teaching Sara Orne Jewett and Mary Wilkins Freeman.

    ERIC Educational Resources Information Center

    Williamson, Judith Barton

    1992-01-01

    Describes how the literary works of Sara Orne Jewett and Mary Wilkins Freeman provide a unique opportunity to look at the lives of older women. Discusses a "life stages" approach to teaching literature. (PRA)

  3. De novo PMP2 mutations in families with type 1 Charcot-Marie-Tooth disease.

    PubMed

    Motley, William W; Palaima, Paulius; Yum, Sabrina W; Gonzalez, Michael A; Tao, Feifei; Wanschitz, Julia V; Strickland, Alleene V; Löscher, Wolfgang N; De Vriendt, Els; Koppi, Stefan; Medne, Livija; Janecke, Andreas R; Jordanova, Albena; Zuchner, Stephan; Scherer, Steven S

    2016-06-01

    We performed whole exome sequencing on a patient with Charcot-Marie-Tooth disease type 1 and identified a de novo mutation in PMP2, the gene that encodes the myelin P2 protein. This mutation (p.Ile52Thr) was passed from the proband to his one affected son, and segregates with clinical and electrophysiological evidence of demyelinating neuropathy. We then screened a cohort of 136 European probands with uncharacterized genetic cause of Charcot-Marie-Tooth disease and identified another family with Charcot-Marie-Tooth disease type 1 that has a mutation affecting an adjacent amino acid (p.Thr51Pro), which segregates with disease. Our genetic and clinical findings in these kindred demonstrate that dominant PMP2 mutations cause Charcot-Marie-Tooth disease type 1. © The Author (2016). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  4. X-linked Charcot-Marie-Tooth disease predominates in a cohort of multiethnic Malaysian patients.

    PubMed

    Shahrizaila, Nortina; Samulong, Sarimah; Tey, Shelisa; Suan, Liaw Chiew; Meng, Lao Kah; Goh, Khean Jin; Ahmad-Annuar, Azlina

    2014-02-01

    Data regarding Charcot-Marie-Tooth disease is lacking in Southeast Asian populations. We investigated the frequency of the common genetic mutations in a multiethnic Malaysian cohort. Patients with features of Charcot-Marie-Tooth disease or hereditary liability to pressure palsies were investigated for PMP22 duplication, deletion, and point mutations and GJB1, MPZ, and MFN2 point mutations. Over a period of 3 years, we identified 25 index patients. A genetic diagnosis was reached in 60%. The most common were point mutations in GJB1, accounting for X-linked Charcot-Marie-Tooth disease (24% of the total patient population), followed by PMP22 duplication causing Charcot-Marie-Tooth disease type 1A (20%). We also discovered 2 novel GJB1 mutations, c.521C>T (Proline174Leucine) and c.220G>A (Valine74Methionine). X-linked Charcot-Marie-Tooth disease was found to predominate in our patient cohort. We also found a better phenotype/genotype correlation when applying a more recently recommended genetic approach to Charcot-Marie-Tooth disease. Copyright © 2013 Wiley Periodicals, Inc.

  5. Classroom Shopping Mall.

    ERIC Educational Resources Information Center

    Davis, Deborah; And Others

    1979-01-01

    Describes a learning activity intended to introduce students in fourth-grade social studies classes to basic business and consumer economics practices. The activity involves forming groups of business partners, deciding on a type of business to set up, deciding how to obtain land and set up a store, creating a money system, advertising, arranging…

  6. Genetic epidemiology of Charcot-Marie-Tooth disease.

    PubMed

    Braathen, G J

    2012-01-01

    Charcot-Marie-Tooth disease (CMT) is the most common inherited disorder of the peripheral nervous system. The frequency of different CMT genotypes has been estimated in clinic populations, but prevalence data from the general population is lacking. Point mutations in the mitofusin 2 (MFN2) gene has been identified exclusively in Charcot-Marie-Tooth disease type 2 (CMT2), and in a single family with intermediate CMT. MFN2 point mutations are probably the most common cause of CMT2. The CMT phenotype caused by mutation in the myelin protein zero (MPZ) gene varies considerably, from early onset and severe forms to late onset and milder forms. The mechanism is not well understood. The myelin protein zero (P(0) ) mediates adhesion in the spiral wraps of the Schwann cell's myelin sheath. X-linked Charcot-Marie Tooth disease (CMTX) is caused by mutations in the connexin32 (cx32) gene that encodes a polypeptide which is arranged in hexameric array and form gap junctions. Estimate prevalence of CMT. Estimate frequency of Peripheral Myelin Protein 22 (PMP22) duplication and point mutations, insertions and deletions in Cx32, Early growth response 2 (EGR2), MFN2, MPZ, PMP22 and Small integral membrane protein of lysosome/late endosome (SIMPLE) genes. Description of novel mutations in Cx32, MFN2 and MPZ. Description of de novo mutations in MFN2. Our population based genetic epidemiological survey included persons with CMT residing in eastern Akershus County, Norway. The participants were interviewed and examined by one geneticist/neurologist, and classified clinically, neurophysiologically and genetically. Two-hundred and thirty-two consecutive unselected and unrelated CMT families with available DNA from all regions in Norway were included in the MFN2 study. We screened for point mutations in the MFN2 gene. We describe four novel mutations, two in the connexin32 gene and two in the MPZ gene. A total of 245 affected from 116 CMT families from the general population of eastern

  7. Using nanoelectrospray ion mobility spectrometry (GEMMA) to determine the size and relative molecular mass of proteins and protein assemblies: a comparison with MALLS and QELS.

    PubMed

    Kapellios, E A; Karamanou, S; Sardis, M F; Aivaliotis, M; Economou, A; Pergantis, S A

    2011-03-01

    The determination of protein assembly size and relative molecular mass is currently of great importance in biochemical analysis. In particular, the technique of nanoelectrospray (nES) with a gas-phase electrophoretic mobility molecular analyzer (GEMMA) has received increased attention for such measurements. However, in order for the GEMMA technique to gain broader acceptance in protein analysis, it must be further evaluated and compared with other established bioanalytical techniques. In the present study, nES-GEMMA was evaluated for the analysis of a set of protein and protein complexes involved in the Sec and the bacterial type III secretion pathway of enteropathogenic Escherichia coli bacteria. The same set of proteins, isolated and purified using standard biochemical protocols, were also analyzed using multi-angle laser light scattering (MALLS) and quasi-elastic light scattering (QELS), following size exclusion chromatography. This allowed for direct comparisons between the three techniques. It was found that nES-GEMMA, in comparison to the more established MALLS and QELS techniques, offers several complementary advantages. It requires considerably less amount of material, i.e., nanogram vs. milligram amounts, and time per sample analysis, i.e., few minutes vs. tens of minutes. Whereas the determined size and relative molecular mass are similar between the compared methods, the electrophoretic diameters determined using nES-GEMMA seem to be systematically smaller compared to the hydrodynamic diameter derived by QELS. Some of the GEMMA technique disadvantages include its narrow dynamic range, limited by the fact that at elevated protein concentrations there is increased potential for the occurrence of nES-induced oligomers. Thus, it is preferred to analyze dilute protein solutions because non-specific oligomers are less likely to occur whereas biospecific oligomers remain detected. To further understand the formation of nES-oligomers, the effect of buffer

  8. Princess Marie Bonaparte, Edgar Allan Poe, and psychobiography.

    PubMed

    Warner, S L

    1991-01-01

    Princess Marie Bonaparte was a colorful yet mysterious member of Freud's inner circle of psychoanalysis. In analysis with Freud beginning in 1925 (she was then 45 years old), she became a lay analyst and writer of many papers and books. Her most ambitious task was a 700-page psychobiography of Edgar Allan Poe that was first published in French in 1933. She was fascinated by Poe's gothic stories--with the return to life of dead persons and the eerie, unexpected turns of events. Her fascination with Poe can be traced to the similarity of their early traumatic life experiences. Bonaparte had lost her mother a month after her birth. Poe's father deserted the family when Edgar was two years old, and his mother died of tuberculosis when he was three. Poe's stories helped him to accommodate to these early traumatic losses. Bonaparte vicariously shared in Poe's loss and the fantasies of the return of the deceased parent in his stories. She was sensitive and empathetic to Poe's inner world because her inner world was similar. The result of this psychological fit between Poe and Bonaparte was her psychobiography, The Life and Works of Edgar Allan Poe. It was a milestone in psychobiography but limited in its psychological scope by its strong emphasis on early childhood trauma. Nevertheless it proved Bonaparte a bona fide creative psychoanalyst and not a dilettante propped up by her friendship with Freud.

  9. ACQUIRED PES CAVUS IN CHARCOT-MARIE-TOOTH DISEASE

    PubMed Central

    Carvalho Maranho, Daniel Augusto; Volpon, José Batista

    2015-01-01

    Hereditary motor and sensory neuropathies, especially Charcot-Marie-Tooth disease, are frequently expressed with an acquired cavusvarus foot which is characterized by a fixed increase of the plantar arch and hindfoot inversion. Diagnosis of the underlying condition achieved through careful patient assessment and local evaluations is the keystone for decision-making about the adequate treatment. The cavus may present as an isolated deformity of the forefoot, hindfoot or it may be a combination of both locations. Related deformities, mainly the varus and toe clawing require appropriate evaluation; clinical characteristics such as severity of the deformity, impairment of the muscular power, flexibility and patient's age are important characteristics in the treatment decision. Conservative treatment of the cavusvarus foot with physiotherapy, insoles and shoe modifications are reserved to young patients and mild deformities. However, there is a tendency of the deformity to become more severe over time because of the progressive feature of the underlying neurological condition. So, the surgical treatment by using classical techniques is performed in early stages. Most importantly is the identification of the primary and main components of each deformity to properly correct them, if possible. Muscular transfers are used to treat the dynamic unbalance, retracted structures should be either divided or lengthened and localized osteotomies should be preferred over arthrodeses, which are reserved for stiff and severely deformed feet in adults. PMID:27077056

  10. ACQUIRED PES CAVUS IN CHARCOT-MARIE-TOOTH DISEASE.

    PubMed

    Carvalho Maranho, Daniel Augusto; Volpon, José Batista

    2009-01-01

    Hereditary motor and sensory neuropathies, especially Charcot-Marie-Tooth disease, are frequently expressed with an acquired cavusvarus foot which is characterized by a fixed increase of the plantar arch and hindfoot inversion. Diagnosis of the underlying condition achieved through careful patient assessment and local evaluations is the keystone for decision-making about the adequate treatment. The cavus may present as an isolated deformity of the forefoot, hindfoot or it may be a combination of both locations. Related deformities, mainly the varus and toe clawing require appropriate evaluation; clinical characteristics such as severity of the deformity, impairment of the muscular power, flexibility and patient's age are important characteristics in the treatment decision. Conservative treatment of the cavusvarus foot with physiotherapy, insoles and shoe modifications are reserved to young patients and mild deformities. However, there is a tendency of the deformity to become more severe over time because of the progressive feature of the underlying neurological condition. So, the surgical treatment by using classical techniques is performed in early stages. Most importantly is the identification of the primary and main components of each deformity to properly correct them, if possible. Muscular transfers are used to treat the dynamic unbalance, retracted structures should be either divided or lengthened and localized osteotomies should be preferred over arthrodeses, which are reserved for stiff and severely deformed feet in adults.

  11. The contribution of women to radiobiology: Marie Curie and beyond.

    PubMed

    Gasinska, Anna

    2016-01-01

    Marie Sklodowska-Curie, an extraordinary woman, a Polish scientist who lived and worked in France, led to the development of nuclear energy and the treatment of cancer. She was the laureate of two Nobel Prizes, the first woman in Europe who obtained the degree of Doctor of Science and opened the way for women to enter fields which had been previously reserved for men only. As a result of her determination and her love of freedom, she has become an icon for many female scientists active in radiation sciences. They are successors of Maria Curie and without the results of their work, improvement in radiation oncology will not be possible. Many of them shared some elements of Maria Curie's biography, like high ethical and moral standards, passionate dedication to work, strong family values, and scientific collaboration with their husbands. The significance of Tikvah Alper, Alma Howard, Shirley Hornsey, Juliana Denekamp, Helen Evans, Eleanor Blakely, Elizabeth L. Travis, Fiona Stewart, Andree Dutreix, Catharine West, Peggy Olive, Ingela Turesson, Penny Jeggo, Irena Szumiel, Eleonor Blakely, Sara Rockwell and Carmel Mothersill contribution to radiation oncology is presented. All the above mentioned ladies made significant contribution to the development of radiotherapy (RT) and more efficient cancer treatment. Due to their studies, new schedules of RT and new types of ionizing radiation have been applied, lowering the incidence of normal tissue toxicity. Their achievements herald a future of personalized medicine.

  12. Charcot Marie Tooth (CMT) Subtypes and Genetic Testing Strategies

    PubMed Central

    Saporta, Anita S.D.; Sottile, Stephanie L.; Miller, Lindsey J.; Feely, Shawna M.E.; Siskind, Carly E; Shy, Michael E.

    2010-01-01

    Background Charcot Marie Tooth disease (CMT) affects one in 2500 people and is caused by mutations in more than 30 genes. Identifying the genetic cause of CMT is often necessary for family planning, natural history studies and for entry into clinical trials. However genetic testing can be both expensive and confusing to patients and physicians. Methods We analyzed data from 1024 of our patients to determine the percentage and features of each CMT subtype within this clinic population. We identified distinguishing clinical and physiological features of the subtypes that could be used to direct genetic testing for patients with CMT. Findings Of 1024 patients evaluated, 787 received CMT diagnoses. Five hundred twenty-seven patients with CMT (67%) received a genetic subtype, while 260 did not have a mutation identified. The most common CMT subtypes were CMT1A, CMT1X, HNPP, CMT1B, and CMT2A. All other subtypes accounted for less than 1% each. Eleven patients had more than one genetically identified subtype of CMT. Patients with genetically identified CMT were separable into specific groups based on age of onset and the degree of slowing of motor nerve conduction velocities. Interpretation Combining features of the phenotypic and physiology groups allowed us to identify patients who were highly likely to have specific subtypes of CMT. Based on these results, we propose a strategy of focused genetic testing for CMT illustrated in a series of flow diagrams created as testing guides. PMID:21280073

  13. The shifting paradigm of Charcot-Marie-Tooth disease.

    PubMed

    Echaniz-Laguna, A

    2015-01-01

    Molecular studies have created a paradigm shift in our perception of Charcot-Marie-Tooth disease (CMT). Indeed, CMT has evolved from the concept of a rather homogeneous hereditary disease exclusively involving peripheral nerves to the concept of a highly heterogeneous clinical and genetic syndrome mainly - but sometimes not exclusively - involving the peripheral nervous system. The phenotypic spectrum of CMT overlaps with other inherited neuropathies such as distal hereditary motor neuropathy (dHMN), hereditary sensory and autonomic neuropathy (HSAN), spinal muscular atrophy (SMA) subtypes, and the neuropathies of mitochondrial disorders. At a molecular level, mutations in one given gene may alternatively provoke CMT, HSAN, dHMN or SMA variants. Over the last years, there have been dramatic advances in deciphering the molecular basis for many CMT subtypes and more than 900 different mutations in more than 60 causative genes are now described. However, as 75% of CMT causative genes apparently remain unknown and as disease-specific therapies are not available, major advances are yet to come in the field of CMT.

  14. Systematic review of exercise for Charcot-Marie-Tooth disease.

    PubMed

    Sman, Amy D; Hackett, Daniel; Fiatarone Singh, Maria; Fornusek, Ché; Menezes, Manoj P; Burns, Joshua

    2015-12-01

    Charcot-Marie-Tooth disease (CMT) is a slowly progressive hereditary degenerative disease and one of the most common neuromuscular disorders. Exercise may be beneficial to maintain strength and function for people with CMT, however, no comprehensive evaluation of the benefits and risks of exercise have been conducted. A systematic review was completed searching numerous electronic databases from earliest records to February 2015. Studies of any design including participants of any age with confirmed diagnosis of CMT that investigated the effects of exercise were eligible for inclusion. Of 13,301 articles identified following removal of duplicates, 11 articles including 9 unique studies met the criteria. Methodological quality of studies was moderate, sample sizes were small, and interventions and outcome measures used varied widely. Although the majority of the studies identified changes in one or more outcome measurements across exercise modalities, the majority were non-significant, possibly due to Type II errors. Significant effects described included improvements in strength, functional activities, and physiological adaptations following exercise. Despite many studies showing changes in strength and function following exercise, findings of this review should be met with caution due to the few studies available and moderate quality of evidence. Well-powered studies, harmonisation of outcome measures, and clearly described interventions across studies would improve the quality and comparability of the evidence base. The optimal exercise modality and intensity for people with CMT as well as the long-term safety of exercise remain unclear.

  15. Modeling protein misfolding in charcot-marie-tooth disease.

    PubMed

    Theocharopoulou, Georgia; Vlamos, Panayiotis

    2015-01-01

    Charcot-Marie-Tooth (CMT) disease is the most common inherited neuromuscular disorder. Recent advancements in molecular biology have elucidated the molecular bases of this genetically heterogeneous neuropathy. Still, the major challenge lies in determining the individual contributions by malfunctions of proteins to the disease's pathology. This paper reviews the identified molecular mechanisms underlying major forms of CMT disease. A growing body of evidence has highlighted the role of protein misfolding in demyelinating peripheral neuropathies and neurodegenerative diseases. Several hypotheses have been proposed to explain how misfolded aggregates induce neuronal damage. Current research focuses on developing novel therapeutic targets which aim to prevent, or even reverse the formation of protein aggregation. Interestingly, the role of the cellular defence mechanisms against accumulation of misfolded proteins may play a key role leading to novel strategies for treatment accelerating the clearance of their toxic early aggregates. Based on these findings we propose a model for describing in terms of a formal computer language, the biomolecular processes involving proteins associated with CMT disease.

  16. [Charcot-Marie-Tooth (CMT) disease: an update].

    PubMed

    Vallat, Jean-Michel; Funalot, Benoît

    2010-10-01

    Charcot-Marie-Tooth (CMT) is the generic name given to a group of genetic disorders characterized by a relatively isolated dysfunction of peripheral nerves, with combined motor and sensory impairment. These CMT syndromes are the most frequent genetically-determined peripheral neuropathies, with a global prevalence between 4.7 and 36/100,000. Their clinical phenotype is predominantly motor, with a grossly symmetrical distal amyotrophy involving both lower and upper limbs. Mode of inheritance is variable: autosomal dominant, autosomal recessive or X-linked. Apparently sporadic forms can be a difficult diagnosis and they must be considered in all patients with a chronic polyneuropathy which is not clearly of acquired origin. During the last two decades, the identification of more than 25 genes mutated in CMT syndromes has complicated the classification of these disorders. Knowledge of the function of some of these genes has improved our understanding of the pathogenesis of myelinic or axonal dysfunction in CMT, but for some others their function remains elusive or unknown.

  17. Murine therapeutic models for Charcot-Marie-Tooth (CMT) disease.

    PubMed

    Fledrich, Robert; Stassart, Ruth M; Sereda, Michael W

    2012-06-01

    Charcot-Marie-Tooth (CMT) disease represents a broad group of inherited motor and sensory neuropathies which can originate from various genetic aberrations, e.g. mutations, deletions and duplications. We performed a literature review on murine animal models of CMT disease with regard to experimental therapeutic approaches. Hereby, we focussed on the demyelinating subforms of CMT (CMT1). PubMed items were CMT, animal model, demyelination and therapy. Patients affected by CMT suffer from slowly progressive, distally pronounced muscle atrophy caused by an axonal loss. The disease severity is highly variable and impairments may result in wheelchair boundness. No therapy is available yet. Numerous rodent models for the various CMT subtypes are available today. The selection of the correct animal model for the specific CMT subtype provides an important prerequisite for the successful translation of experimental findings in patients. Despite more than 20 years of remarkable progress in CMT research, the disease is still left untreatable. There is a growing number of experimental therapeutic strategies that may be translated into future clinical trials in patients with CMT. The slow disease progression and insensitive outcome measures hamper clinical therapy trials in CMT. Biomarkers may provide powerful tools to monitor therapeutic efficacy. Recently, we have shown that transcriptional profiling can be utilized to assess and predict the disease severity in a transgenic rat model and in affected humans.

  18. Charcot-Marie-Tooth disease and other inherited neuropathies.

    PubMed

    Saporta, Mario A

    2014-10-01

    Inherited peripheral neuropathies are among the most common genetic neuromuscular disorders worldwide. However, their diagnosis can be challenging due to genotypic and phenotypic variability. Charcot-Marie-Tooth disease (CMT), the most common form, is associated with mutations or copy-number variations in over 70 genes, representing proteins with fundamental roles in the development and function of Schwann cells and peripheral axons. Other genetic peripheral neuropathies are associated with multisystem manifestations, including familial amyloid neuropathy and neuropathies associated with metabolic or other genetic syndromes. This article reviews the most recent discoveries in the field and how they are changing the way neurologists diagnose this specific group of peripheral neuropathies. In the past few years, several large cohort studies on the molecular diagnosis of CMT have been published, providing guidelines for genetic testing in clinical practice. In the same period, next-generation sequencing technology has accelerated the discovery of new CMT genes, expanding our knowledge on genotype-phenotype correlations. Recent advances in sequencing technology and genotype-phenotype correlation studies are changing the way neurologists diagnose inherited neuropathies. New therapeutic strategies for familial amyloid neuropathy are paving the way for innovative treatments for genetic neuropathies.

  19. Mary Lyon and the hypothesis of random X chromosome inactivation.

    PubMed

    Harper, Peter S

    2011-08-01

    The 50th anniversary of Mary Lyon's 1961 Nature paper, proposing random inactivation in early embryonic life of one of the two X chromosomes in the cells of mammalian females, provides an opportunity to remember and celebrate the work of those involved. While the hypothesis was initially put forward by Lyon based on findings in the mouse, it was founded on earlier studies, notably the work of Susumu Ohno; it was also suggested independently by Beutler and colleagues using experimental evidence from a human X-linked disorder, glucose-6-phosphate dehydrogenase deficiency, and has proved to be of as great importance for human and medical genetics as it has for general mammalian genetics. Alongside the hypothesis itself, previous cytological studies of mouse and human chromosomes, and the observations on X-linked mutants in both species deserve recognition for their essential role in underpinning the hypothesis of random X-inactivation, while subsequent research on the X-inactivation centre and the molecular mechanisms underlying the inactivation process represent some of the most outstanding contributions to human and wider mammalian genetics over the past 50 years.

  20. Current Therapy for Charcot-Marie-Tooth Disease.

    PubMed

    Grandis, Marina; Shy, Michael E

    2005-01-01

    Charcot-Marie-Tooth (CMT), or heritable peripheral neuropathies, is among the most frequent genetic neuromuscular disorders, with a prevalence of approximately 1:2500. Since 1991, remarkable advances have occurred in determining the precise genetic cause of many forms of CMT and in generating animal models of many of these disorders. However, these advances have not yet resulted in cures for CMT. Recently, potential treatments for the most common form of CMT, CMT-1A, have been shown in rodent models of the disorder. Treatment with onapristone, a progesterone antagonist, has improved the neuropathy of the CMT-1A rat. Treatment with large doses of ascorbic acid (vitamin C) has improved the neuropathy of the CMT-1A mouse. Multicentric trials with ascorbic acid are likely to start in the near future to assess if vitamin C supplementation is effective and what is the dosage required in humans to improve neurologic disability. Because of potential side effects with antiprogesterone therapy, particularly in women of child- bearing age, research is actively proceeding with progesterone antagonists to develop safe medications that also can be used in clinical trials of CMT-1A. Although no cures are available for CMT, there are many important treatments available for patients with CMT that can improve their quality of life and help them maintain their independence. Some of these therapies involve physiatry and orthopedic surgery. Others involve pain management. Lastly, there are potential concerns about medications or lifestyle issues that may exacerbate CMT. All of these issues will be discussed.

  1. Ecology and Mary: An Ecological Theology of Mary as the New Eve in Response to the Church's Challenge for a Faith-Based Education in Ecological Responsibility

    ERIC Educational Resources Information Center

    Thurmond, Gloria J.

    2007-01-01

    The Church's interpretation of the current ecological crisis as a moral crisis is the catalyst for this essay, which proposes a newly constructed faith-based model for ecological dialogue and education. The exploration and reinterpretation of the traditional Church doctrine of the Virgin Mary as the new Eve provides a theme from which an…

  2. Marie Curie nurses: enabling patients with cancer to die at home.

    PubMed

    Higginson, Irene J; Wilkinson, Susie

    2002-05-01

    Marie Curie Cancer Care established its nursing service in 1958; however, the service has had little formal evaluation. This study aimed to describe and evaluate the care provided by Marie Curie nurse, and in particular to determine whether patients in their care remained and died at home. Two existing data sets were used: data on all patients referred to the Marie Curie Nursing Services in 147 areas of England, Wales, Scotland and Northern Ireland for 26 months, and data on cancer death registrations in England. A request for a Marie Curie nurse was made for 26,632 patients, 97% of whom had cancer and 11% of whom lived alone. The amount of care provided varied enormously (<1 hour-2862 hours), although the vast majority of patients less than 300 hours of nursing care. Place of death was recorded for only half these patients; 94% died at home, 2.5% in a hospice, 2.3% in a hospital, 0.2% in a nursing home and 0.6% other. Home death was most often associated with patients receiving medication via a syringe driver, patients living with other people, patients with cancer, other than prostate cancer, shorter time between referral and death and younger age. The results lend support to the theory that the care given to patients in their homes by Marie Curie nurses facilitated home death for many patients. Services need to ensure that mechanisms are in place to achieve data collection. Rigorous prospective evaluation is needed in the future.

  3. M-Ary Alpha-Stable Noise Modulation in Spread-Spectrum Communication

    NASA Astrophysics Data System (ADS)

    Cek, Mehmet Emre

    2015-04-01

    In this paper, a spread-spectrum communication system based on a random carrier is proposed which transmits M-ary information. The random signal is considered as a single realization of a random process taken from prescribed symmetric α-stable (SαS) distribution that carries digital M-ary information to be transmitted. Considering the noise model in the channel as additive white Gaussian noise (AWGN), the transmitter sends the information carrying random signal from non-Gaussian density. Alpha-stable distribution is used to encode the M-ary message. Inspired by the chaos shift keying techniques, the proposed method is called M-ary symmetric alpha-stable differential shift keying (M-ary SαS-DSK). The main purpose of preferring non-Gaussian noise instead of conventional pseudo-noise (PN) sequence is to overcome the drawback of self-repeating noise-like sequences which are detectable due to the periodic behavior of the autocorrelation function of PN sequences. Having infinite second order moment in α-stable random carrier offers secrecy of the information due to the non-constant autocorrelation behavior. The bit error rate (BER) performance of the proposed method is illustrated by Monte Carlo simulations with respect to various characteristic exponent values and different data length.

  4. Phenotypic Variability of Childhood Charcot-Marie-Tooth Disease.

    PubMed

    Cornett, Kayla M D; Menezes, Manoj P; Bray, Paula; Halaki, Mark; Shy, Rosemary R; Yum, Sabrina W; Estilow, Timothy; Moroni, Isabella; Foscan, Maria; Pagliano, Emanuela; Pareyson, Davide; Laurá, Matilde; Bhandari, Trupti; Muntoni, Francesco; Reilly, Mary M; Finkel, Richard S; Sowden, Janet; Eichinger, Katy J; Herrmann, David N; Shy, Michael E; Burns, Joshua

    2016-06-01

    Disease severity of childhood Charcot-Marie-Tooth disease (CMT) has not been extensively characterized, either within or between types of CMT to date. To assess the variability of disease severity in a large cohort of children and adolescents with CMT. A cross-sectional study was conducted among 520 children and adolescents aged 3 to 20 years at 8 universities and hospitals involved in the Inherited Neuropathies Consortium between August 6, 2009, and July 31, 2014, in Australia, Italy, the United Kingdom, and the United States. Data analysis was conducted from August 1, 2014, to December 1, 2015. Scores on the Charcot-Marie-Tooth Disease Pediatric Scale (CMTPedS), a well-validated unidimensional clinical outcome measure to assess disease severity. This instrument includes 11 items assessing fine and gross motor function, sensation, and balance to produce a total score ranging from 0 (unaffected) to 44 (severely affected). Among the 520 participants (274 males) aged 3 to 20 years, CMT type 1A (CMT1A) was the most prevalent type (252 [48.5%]), followed by CMT2A (31 [6.0%]), CMT1B (15 [2.9%]), CMT4C (13 [2.5%]), and CMTX1 (10 [1.9%]). Disease severity ranged from 1 to 44 points on the CMTPedS (mean [SD], 21.5 [8.9]), with ankle dorsiflexion strength and functional hand dexterity test being most affected. Participants with CMT1B (mean [SD] CMTPedS score, 24.0 [7.4]), CMT2A (29.7 [7.1]), and CMT4C (29.8 [8.6]) were more severely affected than those with CMT1A (18.9 [7.7]) and CMTX1 (males: 15.3 [7.7]; females: 13.0 [3.6]) (P < .05). Scores on the CMTPedS tended to worsen principally during childhood (ages, 3-10 years) for participants with CMT4C and CMTX1 and predominantly during adolescence for those with CMT1B and CMT2A (ages, 11-20 years), while CMT1A worsened consistently throughout childhood and adolescence. For individual items, participants with CMT4C recorded more affected functional dexterity test scores than did those with all other types of CMT (P

  5. Sleep disorders in Charcot-Marie-Tooth disease type 1.

    PubMed

    Boentert, Matthias; Knop, Katharina; Schuhmacher, Christine; Gess, Burkhard; Okegwo, Angelika; Young, Peter

    2014-03-01

    Obstructive sleep apnoea (OSA) and restless legs syndrome (RLS) have been reported in Charcot-Marie-Tooth disease (CMT) type 1A and axonal subtypes of CMT, respectively. The aim of this case-control study was to investigate both prevalence and severity of OSA, RLS and periodic limb movements in sleep (PLMS) in adult patients with genetically proven CMT1. 61 patients with CMT1 and 61 insomnic control subjects were matched for age, sex, and Body Mass Index. Neurological disability in patients with CMT was assessed using the Functional Disability Scale (FDS). RLS diagnosis was based on a screening questionnaire and structured clinical interviews. All participants underwent overnight polysomnography. OSA was present in 37.7% of patients with CMT1 and 4.9% of controls (p<0.0001). The mean Apnoea Hypoponea Index (AHI) was significantly higher in patients with CMT1 than in control individuals (9.1/h vs 1.2/h). RLS was present in 40.9% of patients with CMT1 and in 16.4% of controls (p<0.001). In the CMT1 group, OSA was significantly more common in men and RLS in women. The AHI correlated with both age and the FDS score, the latter being a significant independent predictor of OSA. PLMS were found in 41.0% of patients with CMT1, but were not correlated with measures of sleep quality. In addition to known risk factors, CMT may predispose to OSA. RLS is highly prevalent not only in axonal subtypes of CMT but also in primarily demyelinating subforms of CMT. PLMS are common in CMT1, but do not significantly impair sleep quality.

  6. Contaminant dispersion at the rehabilitated Mary Kathleen uranium mine, Australia

    NASA Astrophysics Data System (ADS)

    Lottermoser, B. G.; Ashley, P. M.; Costelloe, M. T.

    2005-09-01

    This study reports on the transfer of contaminants from waste rock dumps and mineralised ground into soils, sediments, waters and plants at the rehabilitated Mary Kathleen uranium mine in semi-arid northwest Queensland. Numerous waste rock dumps were partly covered with benign soil and the open pit mine was allowed to flood. The mineralised and waste calc-silicate rock in the open pit and dumps has major (>1 wt%) Ca, Fe and Mg, minor (>1,000 ppm) Ce, La, Mn, P and S, subminor (>100 ppm) Ba, Cu, Th and U, and trace (<100 ppm) As, Ni, Pb, Y and Zn values. Consequently, chemical and physical weathering processes have acted on waste rock and on rock faces within the open pit, mobilising many elements and leading to their dispersion into soils, stream sediments, pit water and several plant species. Chemical dispersion is initiated by sulfide mineral breakdown, generation of sulfuric acid and formation of several soluble, transient sulfate minerals as evaporative efflorescent precipitates. Radiation doses associated with the open pit average 5.65 mSv year-1; waste dumps commonly have lower values, especially where soil-covered. Surface pit water is slightly acid, with high sulfate values accompanied by levels of U, Cu and Ni close to or above Australian water guideline values for livestock. Dispersion of U and related elements into soils and stream sediments occurs by physical (erosional) processes and from chemical precipitation. Plants growing in the mine void, on waste dumps and contaminated soil display evidence of biological uptake of U, LREE, Cu and Th and to a lesser degree of As, Ni, Pb, Y and Zn, with values being up to 1-2 orders of magnitude above background sites for the same species. Although rehabilitation procedures have been partly successful in reducing dispersion of U and related elements into the surrounding environment, it is apparent that 20 years after rehabilitation, there is significant physical and chemical mobility, including transfer into

  7. [Guidelines for molecular diagnosis of Charcot-Marie-Tooth disease].

    PubMed

    Berciano, J; Sevilla, T; Casasnovas, C; Sivera, R; Vílchez, J J; Infante, J; Ramón, C; Pelayo-Negro, A L; Illa, I

    2012-04-01

    Charcot-Marie-Tooth disease (CMT) is the most frequent form of inherited neuropathy. In accordance with the inheritance pattern and degree of slowing of motor conduction velocity (MCV) of the median nerve, CMT encompasses five main forms: CMT1 (autosomal dominant [AD] or X-linked transmission and MCV < 38 m/s); CMT2 (AD or X-linked transmission and MCV > 38 m/s); CMT4 (autosomal recessive [AR] and severe slowing of MCV); AR-CMT2 (AR transmission and MCV > 38 m/s); and DI-CMT (intermediate form with AD transmission and MCV between 30 and 40 m/s). In spite of its stereotyped semiological repertoire (basically, symptoms and signs of sensory-motor polyneuropathy and pes cavus), CMT seems to be one of the most complex hereditary neurodegenerative syndromes, 31 causative genes having been cloned. This paper is aimed at performing a nosological review of the disease, emphasising the guidelines for its molecular diagnosis. Genetic epidemiological studies and genotypes reported in Spanish patients are revised. In the great majority of CMT cases, mutations involve a reduced number of genes, namely: for CMT1, PMP22, GJB1 and MPZ; for CMT2, MFN2 and GJB1; for CMT4, GDAP1, and NDRG1, HK1 and SH3TC2 (gypsies); for AR-CMT2, GDAP1; and for DI-CMT, GJB1 and MPZ. Given their low prevalence, mutations in other pathogenic genes should be investigated after discarding the previous ones. There is no place for the indiscriminate use of diagnostic CMT genetic panels. Copyright © 2011 Sociedad Española de Neurología. Published by Elsevier Espana. All rights reserved.

  8. Cardiac robotics: a review and St. Mary's experience.

    PubMed

    Deeba, S; Aggarwal, R; Sains, P; Martin, S; Athanasiou, T; Casula, R; Darzi, A

    2006-03-01

    The introduction of the laparoscope led to the progress of surgery to a new era, where surgeries that were deemed major are now being performed through keyhole incisions with comparable outcomes to open surgery. However, with this new technique rose several problems like inaccurate depth perception, diminished tactile feedback, need for experienced assistance, and reduction in degrees of motion of the surgeons hands all of which inspired surgeons and engineers to look for mechanical tools to help in reducing these problems. Henceforth; came the application of robotics in surgery. A PubMed and Medline search was performed on cardiac robotic surgery and its applications in mitral valve repair and coronary artery surgery. A total of twenty one articles were picked that allude to the subject. A history of robotic surgery was outlined followed by applications of robotic manipulation in cardiac surgery was narrated. A quick overview of this technology in telemedicine was then outlined followed by future prospects of this technology in surgery was contemplated. The experience of the group from St. Mary's Hospital, London in this field was outlined. During the period of 4 years a total of 102 cases of robotic cardiac surgery were performed. The mean length of hospital stay was 3.1 days with a standard deviation of 1.4 days and the morbidity of the series explained. There was no mortality. Early studies have shown that minimally invasive cardiac surgery is feasible and yields results similar to conventional cardiac surgery, yet it is more technically demanding on the surgeon. As advantageous as this new modality is, further multicenter studies are needed to prove its efficacy. Copyright 2006 John Wiley & Sons, Ltd.

  9. Evaluating Marie Byrd Land stability using an improved basal topography

    NASA Astrophysics Data System (ADS)

    Holschuh, N.; Pollard, D.; Alley, R. B.; Anandakrishnan, S.

    2014-12-01

    Prior understanding of the ice-sheet setting in Marie Byrd Land (MBL) was derived primarily from geologic and geochemical studies of the current nunataks, with very few geophysical surveys imaging the ice covered regions. The geologic context suggested that the ice rests on a broad regional high, in contrast to the deep basins and trenches that characterize the majority of West Antarctica. This assumed topography would favor long-term stability for the West Antarctic Ice Sheet (WAIS) in MBL. Airborne geophysical data collected in 2009 reveal a much deeper bed than previously estimated, including a significant trough underlying DeVicq Glacier and evidence for extensive glacial erosion. Using these data, we produce a new map of subglacial topography, with which we model the sensitivity of WAIS to a warming ocean using the ice-sheet model of Pollard and DeConto (2012b). We compare the results to estimates of ice loss during WAIS collapse using the previously defined subglacial topography, to determine the impact of the newly discovered subglacial features. Our results indicate that the topographic changes are not sufficient to destabilize the northern margin of MBL currently feeding the Getz Ice Shelf; the majority of ice loss occurs from flow toward the Siple Coast. However, despite only slight dynamic differences, using the new bed as a boundary condition results in an additional 8 cm of sea-level rise during major glacial retreat, an increase of just over 2%. Precise estimation of past and future ice retreat, as well as a complete understanding of the geologic history of the region, will require a higher resolution picture of the bed topography around the Executive Committee mountains.

  10. Cranial nerve involvement in Charcot-Marie-Tooth Disease.

    PubMed

    Das, Nirav; Kandalaft, Savannah; Wu, Xiao; Malhotra, Ajay

    2017-03-01

    Charcot-Marie-Tooth Disease (CMT) is a rare disorder with less than 200,000 cases reported in the US every year, making diagnosis challenging. MR and CT imaging has become more common in the evaluation of CMT to identify areas of disease involvement. A 27-year-old female from Guatemala with a past history of polio initially presented to the emergency room for necrotizing pneumonia. MRI images demonstrated smoothly enlarged, mildly enhancing trigeminal nerves. CT showed bony widening of the skull base foramina. The patient was noted to have atrophy and weakness of her extremities with decreased sensation, distal more than proximal, and pes cavus. An electromyogram demonstrated absent response in the right median, ulnar, peroneal, and tibial motor studies and bilateral radial and right sural sensory studies. MRI of the spine demonstrated smooth, symmetric enlargement and mild enhancement of the distal spinal nerve roots and cauda equine. CMT is a group of disorders with a wide range of clinical presentations and abnormalities. Cranial nerve involvement is infrequently described in CMT 1A. In our case and prior studies, there does not appear to be a correlation between cranial nerve involvement and symptoms. Trigeminal neuralgia has been described in patients in CMT, but is not common and was not seen in our patient despite abnormal trigeminal nerve findings on imaging. Our patient also demonstrated involvement of the facial nerve without facial muscle weakness. Clinical features are key in distinguishing CMT 1A from other forms of HMSN. Copyright © 2016 Elsevier Ltd. All rights reserved.

  11. Geology of the Lake Mary quadrangle, Iron County, Michigan

    USGS Publications Warehouse

    Bayley, Richard W.

    1959-01-01

    The Lake Mary quadrangle is in eastern Iron County, in the west part of the Upper Peninsula of Michigan. The quadrangle is underlain by Lower and Middle Precambrian rocks, formerly designated Archean and Algonkian rocks, and is extensively covered by Pleistocene glacial deposits. A few Upper Precambrian (Keweenawan) diabase dikes and two remnants of sandstone and dolomite of early Paleozoic age are also found in the area. The major structural feature is the Holmes Lake anticline, the axis of which strikes northwest through the northeast part of the quadrangle. Most of the quadrangle, therefore, is underlain by rock of the west limb of the anticline. To the northwest along the fold axis, the Holmes Lake anticline is separated from the Amasa oval by a saddle of transverse folds in the vicinity of Michigamme Mountain in the Kiernan quadrangle. The Lower Precambrian rocks are represented by the Dickinson group and by porphyritic red granite whose relation to the Dickinson group is uncertain, but which may be older. The rocks of the Dickinson group are chiefly green to black metavolcanic schist and red felsite, some of the latter metarhyolite. The dark schist is commonly magnetic. The Dickinson group underlies the core area of the Holmes Lake anticline, which is flanked by steeply dipping Middle Precambrian formations of the Animikie series. A major unconformity separates the Lower Precambrian rocks from the overlying Middle Precambrian rocks. In ascending order the formations of the Middle Precambrian are the Randville dolomite, the Hemlock formation, which includes the Mansfield iron-bearing slate member, and the Michigamme slate. An unconformity occurs between the Hemlock formation and Michigamme slate. The post-Hemlock unconformity is thought to be represented in the Lake Mary quadrangle by the absence of iron-formation of the Amasa formation, which is known to lie between the Hemlock and the Michigamme to the northwest of the Lake Mary quadrangle in the Crystal

  12. MARIE: Current Status and Results from 20 Months of Observations at Mars

    NASA Technical Reports Server (NTRS)

    Zeitlin, C.; Andersen, V.; Atwell, W.; Cleghorn, T. F.; Cucinotta, F. A.; Lee, K. T.; Pinsky, L.; Saganti, P.

    2004-01-01

    The MARIE instrument aboard the 2001 Mars Odyssey spacecraft detects energetic charged particles in the Galactic Cosmic Radiation (GCR) and during solar particle events (SPE) [1]. As of this writing (January 2004), MARIE has been turned off, after losing communication with the spacecraft during the large SPE of October 28, 2003. However, during the prior 20 months, MARIE collected data almost continuously, observing several solar events and the nearly-constant GCR. There is still a possibility the instrument can be recovered, and troubleshooting efforts are scheduled to begin in May 2004, following the completion of the primary missions of MER-A (Spirit) and MER-B (Opportunity). At present, Odyssey is acting as a telecommunications relay for the rovers and only routine science operations are permitted in this mode.

  13. Using superconducting undulator for enhanced imaging capabilities of MaRIE

    SciTech Connect

    Yampolsky, Nikolai

    2016-09-22

    MaRIE x-ray free electron laser (FEL) is envisioned to deliver a burst of closely spaced in time pulses for enabling the capability of studying the dynamic processes in a sample. MaRIE capability can be largely enhanced using the superconducting undulator, which has the capability of doubling its period. This technology will allow reaching the photon energy as low as ~200-500 eV. As a result, the MaRIE facility will have a broader photon energy range enabling a larger variety of experiments. The soft x-ray capability is more likely to achieve the 3D imaging of dynamic processes in noncrystal materials than the hard x-ray capability alone.

  14. The Rev. John Bracken v. the Visitors of William and Mary College: A Post-Revolutionary Problem in Visitatorial Jurisdiction.

    ERIC Educational Resources Information Center

    Bridge, J. W.

    1979-01-01

    Reforms in 1779 at the College of William and Mary caused a professor to be dismissed, after which he took legal action against the institution. It is concluded that English corporate law was abused in defending against the professor's action. (Journal availability: College of William and Mary, Williamsburg, VA 23185, $3.00.) (MSE)

  15. 76 FR 31839 - Safety Zones; Annual Events Requiring Safety Zones in the Captain of the Port Sault Sainte Marie...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-02

    ... Fourth of July Celebration Fireworks; Marquette, MI: (i) Location. All U.S. navigable waters of Marquette... section will be enforced July 5 from 9 p.m. until 11 p.m. (2) Munising Fourth of July Celebration.... (4) Sault Sainte Marie Fourth of July Celebration Fireworks; Sault Sainte Marie, MI: (i) Location...

  16. Computation of the bit error rate of coherent M-ary PSK with Gray code bit mapping

    NASA Technical Reports Server (NTRS)

    Lee, P. J.

    1986-01-01

    Efficient computation of the bit error rate (BER) for the coherent M-ary PSK signals with Gray code bit mapping is considered. A closed-form expression for the exact BER of 8-ary PSK is presented. Tight upper and lower bounds on BER are also obtained for M-ary PSK with larger M.

  17. Sister Mary Joseph Nodules on 99mTc HYNIC-TOC scintigraphy in patients with neuroendocrine tumors.

    PubMed

    Jing, Hongli; Zhang, Yingqiang; Li, Fang

    2015-02-01

    A Sister Mary Joseph nodule represents an umbilical metastasis, which is more commonly caused by a primary malignancy in gastrointestinal tract or from reproductive system. We report Sister Mary Joseph nodules caused by neuroendocrine tumor and revealed on Tc HYNIC-TOC scintigraphy.

  18. Biomechanical effects of sensorimotor orthoses in adults with Charcot-Marie-Tooth disease.

    PubMed

    Wegener, Caleb; Wegener, Katrin; Smith, Richard; Schott, Karl-Heinz; Burns, Joshua

    2016-08-01

    Charcot-Marie-Tooth disease is an inherited neuropathy causing progressive weakness, foot deformity and difficulty walking. Clinical anecdotes suggest orthoses designed on the 'sensorimotor' paradigm are beneficial for improving gait in Charcot-Marie-Tooth disease. Investigate the effect of sensorimotor orthoses on in-shoe and lower limb biomechanics in adults with Charcot-Marie-Tooth disease. Randomised, repeated-measures, exploratory study. Eight males and two females with Charcot-Marie-Tooth disease aged 31-68 years fitted with pedorthic shoes and custom-made sensorimotor orthoses were randomly tested at baseline and after 4 weeks of adaptation. In-shoe three-dimensional multi-segment foot and lower limb kinematics and kinetics were collected as were plantar pressures, electromyography and self-reported comfort, stability, cushioning and preference. Compared to the shoe only condition, sensorimotor orthoses increased midfoot eversion and plantarflexion, increased ankle eversion and produced small but significant changes at the knee and hip indicating increased internal rotation. The orthoses increased medial ground reaction forces and increased pressure at the heel, midfoot and toes. There were minimal effects on electromyography. The sensorimotor orthoses were rated higher for comfort, cushioning, stability and preference. Sensorimotor orthoses produced changes in kinematic, kinetic and pressure variables in adults with Charcot-Marie-Tooth disease and were regarded as more comfortable, cushioned and stable during walking. In this study, the walking ability of patients with Charcot-Marie-Tooth disease improved with the use of foot orthoses designed according to the sensorimotor paradigm. However, the mechanism of action appears to be primarily mechanical in origin. Randomised controlled trials are necessary to evaluate the long-term patient-reported outcomes of sensorimotor orthoses. © The International Society for Prosthetics and Orthotics 2015.

  19. Mary's Case: An Illustration of Interprofessional Collaborative Practice for a Child With Severe Disabilities.

    PubMed

    Ogletree, Billy T; Brady, Nancy; Bruce, Susan; Dean, Evan; Romski, MaryAnn; Sylvester, Lorraine; Westling, David

    2017-05-17

    The principles of interprofessional collaborative practice (IPCP) are illustrated through the case of Mary, a child with severe disabilities. Mary's experiences from early childhood to young adulthood are highlighted by both optimal and less-than-ideal examples of clinical services and collaborative practice. The range of collaboration illustrates potential variations in service delivery. Thematic comments and resources are provided by professionals experienced with and committed to IPCP who represent the following four disciplines: occupational therapy, physical therapy, special education, and speech-language pathology. Although potentially challenging, IPCP is a dynamic practice methodology appropriate for speech-language pathologists and others serving persons with severe disabilities.

  20. M-ary suprathreshold stochastic resonance in multilevel threshold systems with signal-dependent noise

    NASA Astrophysics Data System (ADS)

    Cheng, Chaojun; Zhou, Bingchang; Gao, Xiao; McDonnell, Mark D.

    2017-08-01

    We investigate multilevel threshold systems with signal-dependent noise that transmit a common random input signal. We demonstrate the occurrence of M-ary suprathreshold stochastic resonance caused by the signal-dependent noise, and quantify the information enhancement that results relative to the absence of noise. We also find that in the case of M-ary threshold systems, the values of mutual information and signal-to-quantization-noise ratio are larger than the corresponding values in the case of binary threshold systems. These results are potentially useful for understanding the encoding mechanism of inner-ear hair cells and other biological sensory systems.

  1. MARIE Measurements and Model Predictions of Solar Modulation of Galactic Cosmic Rays at Mars

    NASA Technical Reports Server (NTRS)

    Saganti, P. B.; Cucinotta, F. A.; Zeitlin, C. J.; Cleghorn, T. F.; Hu, X.; Lee, K. T.

    2003-01-01

    Recent data from the MARIE (Martian Radiation Environment Experiment) instrument on board the 2001 Mars Odyssey spacecraft currently in Mars orbit are presented. It is shown that the short-term modulations of galactic cosmic rays (GCR) are well described by correlating the so lar modulation parameter, <1>, with Earth-based neutron monitor counts using a 85-day time lag and the NASA Models - HZETRN (High Z and Energy Transport) and QMSFRG (Quantum Multiple Scattering theory of nuclear Fragmentation). The dose rates observed by the MARIE instrument are within 10% of the model calculations.

  2. Charcot-Marie-Tooth Disease Type 1A: Influence of Body Mass Index on Nerve Conduction Studies and on the Charcot-Marie-Tooth Examination Score.

    PubMed

    Jerath, Nivedita U; Shy, Michael E

    2017-09-11

    Charcot-Marie-Tooth Disease type 1A (CMT1A) is caused by a duplication of the peripheral myelin protein gene 22 at chromosome 17p11.2-12. There is limited data regarding whether body mass index (BMI) affects electrophysiological or clinical data in those with CMT1A. Electrophysiological data, the Charcot-Marie-Tooth examination score (CMTES) and BMI from 101 patients with known CMT1A were obtained and analyzed. When controlling for age, a higher BMI does not affect ulnar motor nerve conduction studies in those with CMT1A, but rather components of the CMTES (loss of pinprick and motor strength in the lower extremities). BMI and clinical components of the CMTES are correlated, but it is uncertain which came first-whether the loss of lower extremity pinprick sensation and motor strength results in a higher BMI or if higher BMI results in these signs.

  3. A Rasch Analysis of the Charcot-Marie-Tooth Neuropathy Score (CMTNS) in a Cohort of Charcot-Marie-Tooth Type 1A Patients

    PubMed Central

    Guedj, Mickaël; Bertrand, Viviane; Foucquier, Julie; Jouve, Elisabeth; Commenges, Daniel; Proust-Lima, Cécile; Murphy, Niall P.; Blin, Olivier; Magy, Laurent; Cohen, Daniel; Attarian, Shahram

    2017-01-01

    The Charcot-Marie-Tooth Neuropathy Score (CMTNS) was developed as a main efficacy endpoint for application in clinical trials of Charcot-Marie-Tooth disease type 1A (CMT1A). However, the sensitivity of the CMTNS for measuring disease severity and progression in CMT1A patients has been questioned. Here, we applied a Rasch analysis in a French cohort of patients to evaluate the psychometrical properties of the CMTNS. Overall, our analysis supports the validity of the CMTNS for application to CMT1A patients though with some limitations such as certain items of the CMTNS being more suitable for moderate to severe forms of the disease, and some items being disordered. We suggest that additional items and/or categories be considered to better assess mild-to-moderate patients. PMID:28095456

  4. Civil Rights' Voice and Conscience: Thorough Preparation and Research are Dr. Mary Frances Berry's Formidable Tools.

    ERIC Educational Resources Information Center

    Black Issues in Higher Education, 1994

    1994-01-01

    In an interview, black civil rights leader Mary Frances Berry discusses the dilemmas and opportunities facing African Americans, women, and other minorities from her perspectives as observer and Washington insider. Issues addressed include African-American leadership, transforming knowledge into policy, Afrocentrism, and tensions with other…

  5. The Politics of Thinking About China: 1. Mary Berry on China. 2. Shanker Versus Berry

    ERIC Educational Resources Information Center

    Berry, Mary; Shanker, Albert

    1978-01-01

    Mary Berry's speech suggesting that America had much to learn from Chinese education prompted a sharply critical letter from Albert Shanker, head of the American Federation of Teachers. Parts of the speech and the subsequent exchange with Shanker are reprinted here. (LBH)

  6. Aspects of Community Healing: Experiences of the Sault Sainte Marie Tribe of Chippewa Indians.

    ERIC Educational Resources Information Center

    McBride, Beverly A.

    2003-01-01

    The Sault Sainte Marie tribe of Chippewa Indians (Michigan) facilitated community healing through a curriculum that raised awareness of harmful assimilation factors and the impact of oppression and reintroduced creation stories and the clan system to reclaim American Indian cultural identity. Thirty-two persons completed the first round of…

  7. Mary Miles Bibb: Education and Moral Improvement in the "Voice of the Fugitive."

    ERIC Educational Resources Information Center

    Tripp, Bernell E.

    An ardent antislavery supporter and teacher, Mary Elizabeth Miles Bibb (c.1820-1877) knew the significance of an education and the purpose it would serve, in the classroom and in the newsroom, in establishing a better life for blacks prior to the Civil War. In 1847, her antislavery involvement allowed her to meet her future husband, Henry Bibb,…

  8. Online Opportunist: Mary Ellen Icaza--Montgomery County Public Libraries, Rockville, MD

    ERIC Educational Resources Information Center

    Library Journal, 2004

    2004-01-01

    When Mary Ellen Icaza became Electronic Services Librarian at Montgomery County Public Libraries, she noticed that the readers' services information on the library web site was invisible, even to librarians. "And if staff can't find it," she says, "customers can't." She set out to help people find that material-and to turn a…

  9. Golden Girl: Mary Lai Reflects as She Marks Her 50th Anniversary.

    ERIC Educational Resources Information Center

    Iwanowski, Jay

    1996-01-01

    The career and administrative style of Mary M. Lai, who celebrates her 50th year as chief financial officer at Long Island University (New York), are discussed. Her perspectives on change in higher education and in the institution during that time, the administrator's role, current challenges for financial officers, and the college environment as…

  10. Summer Programs for Gifted Learners at the College of William and Mary.

    ERIC Educational Resources Information Center

    Peterson, Kristina; And Others

    1992-01-01

    The William and Mary Summer Enrichment Program for Gifted Learners serves students in the Williamsburg, Virginia, area from preschool through grade 10, while the Governor's School for Science and Technology serves high school juniors and seniors. A sample course in library skills for at risk verbally talented children (ages five through seven) is…

  11. MaRIE: A facility for time-dependent materials science at the mesoscale

    SciTech Connect

    Barnes, Cris William; Kippen, Karen Elizabeth

    2015-02-11

    To meet new and emerging national security issues the Laboratory is stepping up to meet another grand challenge—transitioning from observing to controlling a material’s performance. This challenge requires the best of experiment, modeling, simulation, and computational tools. MaRIE is the Laboratory’s proposed flagship experimental facility intended to meet the challenge.

  12. Response to Marie Paz Morales' "Influence of Culture and Language Sensitive Physics on Science Attitude Achievement"

    ERIC Educational Resources Information Center

    Cole, Mikel Walker

    2015-01-01

    This response to Marie Paz Morales' "Influence of culture and language sensitive physics on science attitude achievement" explores the ideas of culturally responsive pedagogy and critical literacy to examine some implications for culturally responsive science instruction implicit in the original manuscript. [For "Influence of…

  13. Response to Marie Paz Morales' ``Influence of culture and language sensitive physics on science attitude achievement''

    NASA Astrophysics Data System (ADS)

    Cole, Mikel Walker

    2015-12-01

    This response to Marie Paz Morales' "Influence of culture and language sensitive physics on science attitude achievement" explores the ideas of culturally responsive pedagogy and critical literacy to examine some implications for culturally responsive science instruction implicit in the original manuscript.

  14. Migrating to the City: Negotiating Gender and Race in Marie Arana's "Lima Nights"

    ERIC Educational Resources Information Center

    Heredia, Juanita

    2016-01-01

    This article examines Peruvian-American Marie Arana's second novel "Lima Nights" (2008) in which she represents Amazonian indigenous migrations to Lima, Peru during and after the Shining Path civil war years (1986-2006). As part of a generation of transnational US Latina authors in the post-2000 period, Arana recovers the image of the…

  15. World of John and Mary Smith: A Study of Quirk and Greenbaum's "University Grammar of English."

    ERIC Educational Resources Information Center

    Stephens, Kate

    This paper analyzes the "University Grammar of English" by Randolph Quirk and Sidney Greenbaum (1973) from the point of view of isolation of forms of language from meaning used to convey these forms, especially regarding gender differences and relations in the main characters, John and Mary Smith. It is suggested that females are underrepresented,…

  16. Making Socialists: Mary Bridges Adams and the Fight for Knowledge and Power, 1855-1939

    ERIC Educational Resources Information Center

    Weiler, Kathleen

    2012-01-01

    This article presents a review of "Making socialists: Mary Bridges Adams and the fight for knowledge and power, 1855-1939," by Jane Martin. Jane Martin has explored the history of late-nineteenth-century and early-twentieth century-British women educational activists in numerous publications over the past two decades. Her first book,…

  17. Neuromuscular Hip Dysplasia in Charcot-Marie-Tooth Disease Type 1A

    ERIC Educational Resources Information Center

    Bamford, Nigel S.; White, Klane K.; Robinett, Stephanie A.; Otto, Randolph K.; Gospe, Sidney M., Jr.

    2009-01-01

    Charcot-Marie-Tooth disease (CMT) is one of the most common inherited neurological disorders, affecting 36 in 100,000 people. CMT type 1A (hereditary motor and sensory neuropathy) is the most frequent form of this disease, affecting 60 to 80% of the CMT population, but its diagnosis may be delayed because of inconsistent clinical signs and…

  18. Nerve Excitability Properties in Charcot-Marie-Tooth Disease Type 1A

    ERIC Educational Resources Information Center

    Nodera, Hiroyuki; Bostock, Hugh; Kuwabara, Satoshi; Sakamoto, Takashi; Asanuma, Kotaro; Jia-Ying, Sung; Ogawara, Kazue; Hattori, Naoki; Hirayama, Masaaki; Kaji, Ryuji

    2004-01-01

    Charcot-Marie-Tooth disease type 1A (CMT1A) is commonly considered a prototype of a hereditary demyelinating polyneuropathy. Apart from the myelin involvement, there has been little information on axonal membrane properties in this condition. Taking advantage of the uniform nature of the disease process, we undertook the "in vivo" assessment of…

  19. Mary Cassatt: Celebrating Everyday Life. Teacher's Guide. School Arts: Looking/Learning.

    ERIC Educational Resources Information Center

    Denker, Eric

    Mary Cassatt's paintings and graphics depict the world of 19th-century women, mothers, and children. Her exploration of intimate domestic life is informed by an unsurpassed ability to capture the natural, sometimes awkward poses of her figures and her refusal to "prettify" her subjects. This teaching guide gives an overview of Cassatt's…

  20. From Cradleboard to Motherboard: Buffy Sainte-Marie's Interactive Multimedia Curriculum Transforms Native American Studies.

    ERIC Educational Resources Information Center

    King, Claire

    2000-01-01

    Describes "Science: Through Native American Eyes," an interactive multimedia CD-ROM for middle school that is part of the Cradleboard Teaching Project developed by musician and teacher Buffy Sainte-Marie. The Cradleboard joins Native American tradition and high-tech innovation to explore the core curriculum of the National Content Standards. (SLD)

  1. A DIY Campus Preservation Plan: Lessons Learned at the University of Mary Washington

    ERIC Educational Resources Information Center

    Smith, Andrea Livi; Spencer, Michael

    2012-01-01

    The University of Mary Washington (UMW) in Fredericksburg, Virginia, was founded in 1908. This article describes the process that led to the UMW preservation plan. Unlike most preservation plans, the UMW plan was developed in-house with limited funds. Furthermore, the catalyst for the plan was a grassroots effort on the part of students and alumni…

  2. Neuromuscular Hip Dysplasia in Charcot-Marie-Tooth Disease Type 1A

    ERIC Educational Resources Information Center

    Bamford, Nigel S.; White, Klane K.; Robinett, Stephanie A.; Otto, Randolph K.; Gospe, Sidney M., Jr.

    2009-01-01

    Charcot-Marie-Tooth disease (CMT) is one of the most common inherited neurological disorders, affecting 36 in 100,000 people. CMT type 1A (hereditary motor and sensory neuropathy) is the most frequent form of this disease, affecting 60 to 80% of the CMT population, but its diagnosis may be delayed because of inconsistent clinical signs and…

  3. Nerve Excitability Properties in Charcot-Marie-Tooth Disease Type 1A

    ERIC Educational Resources Information Center

    Nodera, Hiroyuki; Bostock, Hugh; Kuwabara, Satoshi; Sakamoto, Takashi; Asanuma, Kotaro; Jia-Ying, Sung; Ogawara, Kazue; Hattori, Naoki; Hirayama, Masaaki; Kaji, Ryuji

    2004-01-01

    Charcot-Marie-Tooth disease type 1A (CMT1A) is commonly considered a prototype of a hereditary demyelinating polyneuropathy. Apart from the myelin involvement, there has been little information on axonal membrane properties in this condition. Taking advantage of the uniform nature of the disease process, we undertook the "in vivo" assessment of…

  4. Marie Zimmermann Farm, U.S. Route 209, 5 Miles Southwest of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Marie Zimmermann Farm, U.S. Route 209, 5 Miles Southwest of Milford. The property is defined at its northern boundary by Zimmermann Road and at the west by Long Meadow Road. The east boundary of the parcel is the edge of the Delaware River. The south edge of the parcel is irregularly oriented east-to-west. , Milford, Pike County, PA

  5. 77 FR 29916 - Proposed Amendment of Class D Airspace; Sault Ste Marie, ON

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-21

    ... is necessary to coincide with the Canadian control zone over Sault Ste Marie Airport. The FAA is taking this action to enhance the safety and management of Instrument Flight Rules (IFR) operations at... airspace to coincide with that portion of the control zone in Canadian airspace. Controlled airspace...

  6. 77 FR 56796 - Proposed Amendment of Class E Airspace; Sault Ste Marie, ON

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-14

    ... are necessary to coincide with the Canadian control zone over Sault Ste Marie Airport. The FAA is taking this action to enhance the safety and management of Instrument Flight Rules (IFR) operations at..., ON, to coincide with that portion of the control zone in Canadian airspace. Controlled airspace...

  7. Mary Pickersgill: The Woman Who Sewed the Star-Spangled Banner

    ERIC Educational Resources Information Center

    Smith, Megan; Wei, Jenny

    2013-01-01

    Just imagine: you live in a time before electricity. There are no sewing machines, no light bulbs, and certainly no television shows to keep you entertained. You spend six days a week working 12-hours each day inside your small home with four teenage girls and your elderly mother. This was the life of Mary Pickersgill, the woman who sewed the…

  8. 106. Catalog OPark Structure/Construction & Maintenance, 23 Marys Rock Tunnel, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    106. Catalog O-Park Structure/Construction & Maintenance, 23 Marys Rock Tunnel, Negative No. 638 17 E. Ray Schaffner, Photographer, December 5, 1957 ICICLES IN TUNNEL. - Skyline Drive, From Front Royal, VA to Rockfish Gap, VA , Luray, Page County, VA

  9. Women, Education and the Material Body Politic in Mary Wollstonecraft's "Vindications"

    ERIC Educational Resources Information Center

    Bernath, Elizabeth

    2016-01-01

    This paper discusses Mary Wollstonecraft's "A Vindication of the Rights of Woman: With Strictures on Political and Moral Subjects" and "A Vindication of the Rights of Men" as books of philosophy about rational materialism. Based on an analysis of Lockean thought, as applied to the possibility of women's development of reason,…

  10. The Gendering of Albert Einstein and Marie Curie in Children's Biographies: Some Tensions

    ERIC Educational Resources Information Center

    Wilson, Rachel E.; Jarrard, Amber R.; Tippins, Deborah J.

    2009-01-01

    Few twentieth century scientists have generated as much interest as Albert Einstein and Marie Currie. Their lives are centrally depicted in numerous children's biographies of famous scientists. Yet their stories reflect interesting paradoxes and tacit sets of unexplored sociocultural assumptions about gender in science education and the larger…

  11. The Ability to Persuade People To Change: An Interview with Mary Hatwood Futrell.

    ERIC Educational Resources Information Center

    Goldberg, Mark F.

    2001-01-01

    Formerly National Education Association president, Mary Futrell got NEA to support the National Board for Professional Teaching Standards and helped shift NEA's focus to professional development and human-rights issues. She believes teachers must help state and district entities set academic and professional-development standards. (MLH)

  12. Dr. Mary McLeod Bethune: A Life Devoted to Service

    ERIC Educational Resources Information Center

    Long, Kim Cliett

    2011-01-01

    The purpose of this paper is to explore and analyze the leadership traits of Dr. Mary McLeod Bethune, an African-American woman of history, using the servant leadership theory developed by Robert K. Greenberg and the ten characteristics of servant leadership as conceived by Larry C. Spears. This exploration seeks to identify the significant…

  13. Unheralded Historian: Mary Sheldon Barnes and Primary Source Material in History Books

    ERIC Educational Resources Information Center

    Chisholm, James A., Jr.

    2013-01-01

    In the latter part of the nineteenth century, Mary Sheldon Barnes emerged as a leading historical methods professor and history textbook author. Although men dominated the field, she wrote several articles and books alone or with her husband Earl Barnes about primary source materials and teaching. She lived during an era in United States history…

  14. Mary Pickersgill: The Woman Who Sewed the Star-Spangled Banner

    ERIC Educational Resources Information Center

    Smith, Megan; Wei, Jenny

    2013-01-01

    Just imagine: you live in a time before electricity. There are no sewing machines, no light bulbs, and certainly no television shows to keep you entertained. You spend six days a week working 12-hours each day inside your small home with four teenage girls and your elderly mother. This was the life of Mary Pickersgill, the woman who sewed the…

  15. Migrating to the City: Negotiating Gender and Race in Marie Arana's "Lima Nights"

    ERIC Educational Resources Information Center

    Heredia, Juanita

    2016-01-01

    This article examines Peruvian-American Marie Arana's second novel "Lima Nights" (2008) in which she represents Amazonian indigenous migrations to Lima, Peru during and after the Shining Path civil war years (1986-2006). As part of a generation of transnational US Latina authors in the post-2000 period, Arana recovers the image of the…

  16. Open Concept School for Indian Education. Sault Sainte Marie, Michigan, 1973.

    ERIC Educational Resources Information Center

    Sault Sainte Marie Public Schools, MI.

    The product of an Elementary Secondary Education Act Title III project produced by the staff and administration of the Finlayson Elementary School in Sault Ste. Marie, Michigan for American Indian students, this handbook is designed as a guide to educators engaging in open concept education. Constituting a model, this handbook incorporates the…

  17. Rediscovering the Art of Developmental Therapy: An Interview with Mary M. Wood

    ERIC Educational Resources Information Center

    Teagarden, James M.; Kaff, Marilyn S.; Zabel, Robert H.

    2013-01-01

    Dr. Mary Margaret Wood is best known for developing psychoeducational programs that integrate mental health and special education interventions for children with emotional and behavioral disorders (EBD). Developmental Therapy (DT) includes comprehensive assessment of student behavior, communication, social, and cognitive development,…

  18. Assessing a Couple's Relationship and Compatibility Using the MARI[R] Card Test and Mandala Drawings

    ERIC Educational Resources Information Center

    Frame, Phyllis G.

    2006-01-01

    This paper illustrates the use of the MARI[R] Card Test, a transpersonal assessment tool which includes archetypal designs and color choices, as well as the drawing of a white and black mandala, or circle picture, for assessing the compatibility of two people in a committed relationship. In an informal pilot research study, 22 couples were given…

  19. On a New Detection Scheme for M-ary Orthogonal Coherent State Signal

    NASA Technical Reports Server (NTRS)

    Yamazaki, Kouichi

    1996-01-01

    We propose a new receiver for M-ary orthogonal coherent-state signal. It is shown that the proposed receiver performs better than a photon counting receiver as to signal detection error probability criterion. It is also shown that the error probability of the proposed receiver is almost minimum for the signal.

  20. Mary Lee Settle and the Mountain Kingdom: A World Where Nobody Forgets Anything.

    ERIC Educational Resources Information Center

    Woodside, Jane Harris

    1992-01-01

    Novelist Mary Lee Settle reminiscences about growing up in an Appalachian coal mining town and how she uses her life experiences as a back drop for developing stories and characters for her novels. She discusses family history, coal mine violence, and the proud heritage and culture of Appalachians. (LP)

  1. The Gendering of Albert Einstein and Marie Curie in Children's Biographies: Some Tensions

    ERIC Educational Resources Information Center

    Wilson, Rachel E.; Jarrard, Amber R.; Tippins, Deborah J.

    2009-01-01

    Few twentieth century scientists have generated as much interest as Albert Einstein and Marie Currie. Their lives are centrally depicted in numerous children's biographies of famous scientists. Yet their stories reflect interesting paradoxes and tacit sets of unexplored sociocultural assumptions about gender in science education and the larger…

  2. Living Proof: What Helen Keller, Marilyn Monroe, and Marie Curie Have in Common.

    ERIC Educational Resources Information Center

    Saul, E. Wendy

    1986-01-01

    Examines biographies of Marie Curie written for children and discusses two types of distortions: simple misrepresentations of fact and selective retelling of the past. It is concluded that biographies of minority or female success should deal specifically with strategies used by the hero or heroine to combat prejudice. (EM)

  3. Mary Carroll Craig Bradford: Providing Opportunities to Colorado's Women and Children through Suffrage and Education

    ERIC Educational Resources Information Center

    Caldwell, Heather Kleinpeter

    2009-01-01

    This dissertation is a historical biography on the life, suffrage and educational contributions of Mary Carroll Craig Bradford, a wife, mother, suffragist, teacher and educational administrator in the state of Colorado. The purpose of this dissertation was to find out exactly what Bradford's contributions were to her state. The initial observation…

  4. Reclaiming a Lost Leader: Mary Perkins Ryan, Visionary in Modern Catholic Education

    ERIC Educational Resources Information Center

    Heekin, Ann Morrow

    2008-01-01

    Mary Perkins Ryan remains one of the least recognized of the twentieth-century figures in the modern renewal of Catholic education in the United States. The reasons are many but none satisfactory. Ryan was an intellectual without a scholarly credential. She was an educator without an affiliation to an academic institution. She was a leading voice…

  5. A DIY Campus Preservation Plan: Lessons Learned at the University of Mary Washington

    ERIC Educational Resources Information Center

    Smith, Andrea Livi; Spencer, Michael

    2012-01-01

    The University of Mary Washington (UMW) in Fredericksburg, Virginia, was founded in 1908. This article describes the process that led to the UMW preservation plan. Unlike most preservation plans, the UMW plan was developed in-house with limited funds. Furthermore, the catalyst for the plan was a grassroots effort on the part of students and alumni…

  6. Novels, Thought Experiments, and Humanist Sociology in the Classroom: Mari Sandoz and CAPITAL CITY.

    ERIC Educational Resources Information Center

    Hill, Michael R.

    1987-01-01

    Based upon the teaching of Mari Sandoz' allegorical novel, CAPITAL CITY, this article identifies the characteristics of novels which provide a sociologically useful humanist perspective. A key characteristic is the extent to which the novel conducts thought experiments, defined as cerebral exercises which explore alternative social futures based…

  7. Strangers and Orphans: Knowledge and Mutuality in Mary Shelley's "Frankenstein"

    ERIC Educational Resources Information Center

    Gomez, Claudia Rozas

    2013-01-01

    Paulo Freire consistently upheld humanization and mutuality as educational ideals. This article argues that conceptualizations of knowledge and how knowledge is sought and produced play a role in fostering humanization and mutuality in educational contexts. Drawing on Mary Shelley's novel "Frankenstein," this article focuses on the…

  8. Re-Birthing the Monstrous: James Whale's (Mis)Reading of Mary Shelley's "Frankenstein."

    ERIC Educational Resources Information Center

    Picart, Caroline Joan S.

    1998-01-01

    Contributes to scholarship on film and feminism by showing how James Whale's film attempts to excise or severely delimit the disturbing critique of the Romantic politics of gender in Mary Shelley's novel "Frankenstein." Discusses parthenogenesis, showing how the novel critiques the Romantic rhetorical reconstructions of masculine…

  9. Manifest Destiny's Child: Mary Hazelton Blanchard Wade and the Literature of American Empire

    ERIC Educational Resources Information Center

    Tunc, Tanfer Emin

    2017-01-01

    This article discusses how, following in the footsteps of United States imperial children's writers Jacob Abbott and Edward Stratemeyer, Mary Hazelton Blanchard Wade (1860-1936), the original author of the "Our Little Cousins" series (1901-1905), contributed to the American culture of empire. Wade was one of the most prolific and popular…

  10. Response to Marie Paz Morales' "Influence of Culture and Language Sensitive Physics on Science Attitude Achievement"

    ERIC Educational Resources Information Center

    Cole, Mikel Walker

    2015-01-01

    This response to Marie Paz Morales' "Influence of culture and language sensitive physics on science attitude achievement" explores the ideas of culturally responsive pedagogy and critical literacy to examine some implications for culturally responsive science instruction implicit in the original manuscript. [For "Influence of…

  11. From Cradleboard to Motherboard: Buffy Sainte-Marie's Interactive Multimedia Curriculum Transforms Native American Studies.

    ERIC Educational Resources Information Center

    King, Claire

    2000-01-01

    Describes "Science: Through Native American Eyes," an interactive multimedia CD-ROM for middle school that is part of the Cradleboard Teaching Project developed by musician and teacher Buffy Sainte-Marie. The Cradleboard joins Native American tradition and high-tech innovation to explore the core curriculum of the National Content Standards. (SLD)

  12. Mary Ritter Beard and Marion Thompson Wright: Shaping Inclusive Social Education.

    ERIC Educational Resources Information Center

    Crocco, Margaret Smith

    1997-01-01

    Examines contributions by Mary Ritter Beard and Marion Thompson Wright to inclusive social education curricula. Beard established the field of women's history; Wright promoted the application of black history. Both saw social betterment as the goal of knowledge and sought inclusive understanding of the nature of legitimate knowledge in schools.…

  13. [PREGNANCY AND DELIVERY IN A PATIENT WITH CHARCOT-MARIE-TOOTH DISEASE].

    PubMed

    Pehlivanov, B; Matev, M

    2016-01-01

    We report a case of a 34 years old primigravida with Charcot-Marie-Tooth disease (CMTD). The course of pregnancy was uneventful with no deterioration of symptoms due to the disease. Performed amniocentesis showed healthy fetus. Planned cesarean section with spinal anesthesia was performed because of the restricted pelvis. The possible issues of combination pregnancy and CMTD are discussed.

  14. Women in History: Mary Parker Follett--A Leadership Theorist Ahead of Her Time

    ERIC Educational Resources Information Center

    Gaspar, Sandy

    2004-01-01

    This article profiles Mary Parker Follet, a management and leadership voice in the 1920s and 30s who was far ahead of her time. Throughout her lifetime, Follet refused to accept the dualities and dichotomies that threatened to divide individuals and organizations. In her book, "The New State," Follet argued that group organization and…

  15. Strangers and Orphans: Knowledge and Mutuality in Mary Shelley's "Frankenstein"

    ERIC Educational Resources Information Center

    Gomez, Claudia Rozas

    2013-01-01

    Paulo Freire consistently upheld humanization and mutuality as educational ideals. This article argues that conceptualizations of knowledge and how knowledge is sought and produced play a role in fostering humanization and mutuality in educational contexts. Drawing on Mary Shelley's novel "Frankenstein," this article focuses on the…

  16. St Thomas' hospital is the wrong site for mary seacole statue.

    PubMed

    McDonald, Lynn

    2012-05-16

    Your news story, 'Council gives go-ahead for Seacole statue' (May 2), is orrect in declaring that planning permission for a memorial statue for Mary Seacole has been granted. But the plans have been approved by Lambeth Council's planning committee, rather than the council as a whole.

  17. Breaking the Boundaries of Victorian Imperialism or Extending a Reformed 'Paternalism'? Mary Carpenter and India.

    ERIC Educational Resources Information Center

    Watts, Ruth

    2000-01-01

    Discusses the debate on gender and imperialism in India by examining the case of Mary Carpenter, a nineteenth century English educationist and social reformer, in order to provide more information on the debate. Addresses where Carpenter stood in the discourse on imperialism. (CMK)

  18. Unheralded Historian: Mary Sheldon Barnes and Primary Source Material in History Books

    ERIC Educational Resources Information Center

    Chisholm, James A., Jr.

    2013-01-01

    In the latter part of the nineteenth century, Mary Sheldon Barnes emerged as a leading historical methods professor and history textbook author. Although men dominated the field, she wrote several articles and books alone or with her husband Earl Barnes about primary source materials and teaching. She lived during an era in United States history…

  19. Mary Sheldon Barnes and the Introduction of Social Sciences in Public Schools.

    ERIC Educational Resources Information Center

    Saxe, David Warren

    1989-01-01

    Presents the source method that Mary Sheldon Barnes publicized in her book, "Studies in General History" in 1885. Defines the source method as the thorough examination of original source materials through the application of systematic inquiry tools. Points out that Barnes combined the study of history with the study of contemporary life.…

  20. Life as the Middle Child: A Conversation With Mary Margaret Kerr

    ERIC Educational Resources Information Center

    Teagarden, James M.; Zabel, Robert H.; Kaff, Marilyn S.

    2015-01-01

    As part of an ongoing oral history project, a conversation was held with Dr. Mary Margaret Kerr on the past, present, and possible future of the field of providing services to children with emotional-behavioral disorders. Dr. Wood stresses the increasing importance of providing an interdisciplinary approach to meet the needs for children or, as…

  1. Mary Lincoln's Madness: Understanding the Factors that Influence the Diagnosis and Treatment of Bipolar Disorder

    ERIC Educational Resources Information Center

    Dick, Carina; Renes, Susan L.; Strange, Anthony T.

    2010-01-01

    Mary Lincoln, wife of President Abraham Lincoln, lived a tragic life. Beginning with the death of her mother when she was a little girl, Mrs. Lincoln experienced a number of family deaths, including three brothers, three sons, and the murder of her beloved husband while she sat by his side. In addition to tragedy, Mrs. Lincoln suffered from poor…

  2. The design and research of anti-color-noise chaos M-ary communication system

    SciTech Connect

    Fu, Yongqing Li, Xingyuan; Li, Yanan; Zhang, Lin

    2016-03-15

    Previously a novel chaos M-ary digital communication method based on spatiotemporal chaos Hamilton oscillator has been proposed. Without chaos synchronization circumstance, it has performance improvement in bandwidth efficiency, transmission efficiency and anti-white-noise performance compared with traditional communication method. In this paper, the channel noise influence on chaotic modulation signals and the construction problem of anti-color-noise chaotic M-ary communication system are studied. The formula of zone partition demodulator’s boundary in additive white Gaussian noise is derived, besides, the problem about how to determine the boundary of zone partition demodulator in additive color noise is deeply studied; Then an approach on constructing anti-color-noise chaos M-ary communication system is proposed, in which a pre-distortion filter is added after the chaos baseband modulator in the transmitter and whitening filter is added before zone partition demodulator in the receiver. Finally, the chaos M-ary communication system based on Hamilton oscillator is constructed and simulated in different channel noise. The result shows that the proposed method in this paper can improve the anti-color-noise performance of the whole communication system compared with the former system, and it has better anti-fading and resisting disturbance performance than Quadrature Phase Shift Keying system.

  3. Magic Women on the Margins: Ec-Centric Models in Mary Poppins and Ms Wiz

    ERIC Educational Resources Information Center

    Valverde, Cristina Perez

    2009-01-01

    This paper offers a comparative analysis of two characters belonging to the tradition of empowered "spinster" in children's fiction, namely Mary Poppins and Ms Wiz, from the perspective of gender politics and child/adult interactions. A distinction is made between the figure portrayed in P. L. Travers' texts and the Disney film starring Julie…

  4. Walt Disney Meets Mary Daly: Invention, Imagination, and the Construction of Community.

    ERIC Educational Resources Information Center

    Covino, William A.

    2000-01-01

    Posits Walt Disney as an influential sorcerer in the process of integrating the real world into Disney's synthetic universe, and Mary Daly's work "Wickedary" as a work that constructs an alternative "magic kingdom" through an insistence on an anti-patriarchal lexicon. (NH)

  5. 75 FR 22436 - Michael Williams-Control Exemption-St. Maries River Railroad, Inc.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-28

    ... Surface Transportation Board Michael Williams-Control Exemption-St. Maries River Railroad, Inc. Michael Williams (applicant),\\1\\ a noncarrier, has filed a verified notice of exemption to acquire control of St... from STMA's parent, Potlatch Land & Lumber, LLC, by Williams Group, Inc. (WG).\\2\\ Applicant...

  6. Profile of District Transfers to the University of California, California State University, and St. Mary's College.

    ERIC Educational Resources Information Center

    Baratta, Frank

    The Contra Costa Community College District (CCCCD), in California, conducted a study to determine the type and number of transfer students served by both the CCCCD and by the University of California (UC), the California State University (CSU), or St. Mary's College (SMC) between 1982-83 and 1989-90. The study also assessed the completeness and…

  7. Water Quality Protection of the Grand Lake St. Marys in Ohio

    EPA Science Inventory

    Grand Lake St. Marys (GLSM) in northwestern Ohio is experiencing toxic levels of algal blooms resulting from nutrients, especially phosphorus (P) input from agricultural runoff. Originally constructed as a feeder reservoir for the Miami and Erie Canal, recreation activities on t...

  8. Magic Women on the Margins: Ec-Centric Models in Mary Poppins and Ms Wiz

    ERIC Educational Resources Information Center

    Valverde, Cristina Perez

    2009-01-01

    This paper offers a comparative analysis of two characters belonging to the tradition of empowered "spinster" in children's fiction, namely Mary Poppins and Ms Wiz, from the perspective of gender politics and child/adult interactions. A distinction is made between the figure portrayed in P. L. Travers' texts and the Disney film starring Julie…

  9. Walt Disney Meets Mary Daly: Invention, Imagination, and the Construction of Community.

    ERIC Educational Resources Information Center

    Covino, William A.

    2000-01-01

    Posits Walt Disney as an influential sorcerer in the process of integrating the real world into Disney's synthetic universe, and Mary Daly's work "Wickedary" as a work that constructs an alternative "magic kingdom" through an insistence on an anti-patriarchal lexicon. (NH)

  10. The Martian Radiation Environment Experiment (MARIE) on the 2001 Mars Odyssey Spacecraft

    NASA Astrophysics Data System (ADS)

    Atwell, William

    2003-01-01

    The 2001 Mars Odyssey spacecraft was launched to Mars on April 7, 2001, and reached Mars in late October 2001. Following arrival at Mars, a series of aero-braking maneuvers were performed to place the spacecraft in a ~400 km altitude orbit at Mars. One of the experiments on board the spacecraft is the Martian Radiation Environment Experiment (MARIE), which was designed to measure the galactic cosmic radiation (GCR) environment in the energy range from 20 - 500 MeV/u during the cruise phase to Mars and while in Mars orbit. The experiment is also capable of measuring solar particle events (SPE) in the same energy range. During the cruise phase a communication problem with the MARIE was encountered from early August until early March 2002 when communication was re-established. In this paper the MARIE experiment is discussed in detail. The GCR measured data are compared with the GCR model environment. Several solar particle events that have been observed by MARIE are compared with the near-Earth GOES satellite SPE data. These data represent a ``first ever'' GCR and SPE measurements in the vicinity of Mars and will be used to establish some guidelines for future human missions to Mars. The SPE data can also be utilized to compare with existing SPE interplanetary propagation models.

  11. Online Opportunist: Mary Ellen Icaza--Montgomery County Public Libraries, Rockville, MD

    ERIC Educational Resources Information Center

    Library Journal, 2004

    2004-01-01

    When Mary Ellen Icaza became Electronic Services Librarian at Montgomery County Public Libraries, she noticed that the readers' services information on the library web site was invisible, even to librarians. "And if staff can't find it," she says, "customers can't." She set out to help people find that material-and to turn a…

  12. Living Proof: What Helen Keller, Marilyn Monroe, and Marie Curie Have in Common.

    ERIC Educational Resources Information Center

    Saul, E. Wendy

    1986-01-01

    Examines biographies of Marie Curie written for children and discusses two types of distortions: simple misrepresentations of fact and selective retelling of the past. It is concluded that biographies of minority or female success should deal specifically with strategies used by the hero or heroine to combat prejudice. (EM)

  13. Seven Lessons Learned from General Education Reform at Saint Mary's College

    ERIC Educational Resources Information Center

    Incandela, Joseph M.

    2011-01-01

    Saint Mary's College, a single-gender Catholic institution in northern Indiana with approximately 1,600 students, has just revised a general education curriculum that had been in place for nearly forty years. The board of trustees unanimously approved the new curriculum in April 2010. In this article, the author discusses seven key lessons learned…

  14. Mary Lincoln's Madness: Understanding the Factors that Influence the Diagnosis and Treatment of Bipolar Disorder

    ERIC Educational Resources Information Center

    Dick, Carina; Renes, Susan L.; Strange, Anthony T.

    2010-01-01

    Mary Lincoln, wife of President Abraham Lincoln, lived a tragic life. Beginning with the death of her mother when she was a little girl, Mrs. Lincoln experienced a number of family deaths, including three brothers, three sons, and the murder of her beloved husband while she sat by his side. In addition to tragedy, Mrs. Lincoln suffered from poor…

  15. Water Quality Protection of the Grand Lake St. Marys in Ohio

    EPA Science Inventory

    Grand Lake St. Marys (GLSM) in northwestern Ohio is experiencing toxic levels of algal blooms resulting from nutrients, especially phosphorus (P) input from agricultural runoff. Originally constructed as a feeder reservoir for the Miami and Erie Canal, recreation activities on t...

  16. Science and Special Needs at Mary Hare School for the Deaf.

    ERIC Educational Resources Information Center

    Wright, Kevin

    2002-01-01

    Introduces the Mary Hare School which caters to academically able but very deaf children and explains the philosophy of a school that uses an oral approach to enable all students to have access to the normal curriculum and maximize their potential. (Author/YDS)

  17. 99mTc-DMSA Uptake in a Sister Mary Joseph's Nodule From Ovarian Cancer.

    PubMed

    Naddaf, Sleiman; Azzumeea, Fahad; Fahad Alzayed, Mohammed

    2016-12-01

    A 50-year-old woman with ovarian cancer underwent Tc-DMSA scan to evaluate the functional status of the right hydronephrotic kidney. The images incidentally revealed a well-defined focus of mild radiotracer uptake at the midanterior abdominal wall, which correlated with a metastatic Sister Mary Joseph's nodule seen on CT performed a week earlier.

  18. The design and research of anti-color-noise chaos M-ary communication system

    NASA Astrophysics Data System (ADS)

    Fu, Yongqing; Li, Xingyuan; Li, Yanan; Zhang, Lin

    2016-03-01

    Previously a novel chaos M-ary digital communication method based on spatiotemporal chaos Hamilton oscillator has been proposed. Without chaos synchronization circumstance, it has performance improvement in bandwidth efficiency, transmission efficiency and anti-white-noise performance compared with traditional communication method. In this paper, the channel noise influence on chaotic modulation signals and the construction problem of anti-color-noise chaotic M-ary communication system are studied. The formula of zone partition demodulator's boundary in additive white Gaussian noise is derived, besides, the problem about how to determine the boundary of zone partition demodulator in additive color noise is deeply studied; Then an approach on constructing anti-color-noise chaos M-ary communication system is proposed, in which a pre-distortion filter is added after the chaos baseband modulator in the transmitter and whitening filter is added before zone partition demodulator in the receiver. Finally, the chaos M-ary communication system based on Hamilton oscillator is constructed and simulated in different channel noise. The result shows that the proposed method in this paper can improve the anti-color-noise performance of the whole communication system compared with the former system, and it has better anti-fading and resisting disturbance performance than Quadrature Phase Shift Keying system.

  19. Mary Wollstonecraft, Margaret Fuller, and Angelina Grimke: Symbolic Convergence and a Nascent Rhetorical Vision.

    ERIC Educational Resources Information Center

    Huxman, Susan Schultz

    1996-01-01

    Invites rhetorical critics to reappraise the way they study discreet social movements and pay isolated tribute to woman's rights figures. Examines how Mary Wollstonecraft, Margaret Fuller, and Angelina Grimke each co-opted the ideational and stylistic rhetorical characteristics of pre-existing social movements (the enlightenment,…

  20. Mary Carroll Craig Bradford: Providing Opportunities to Colorado's Women and Children through Suffrage and Education

    ERIC Educational Resources Information Center

    Caldwell, Heather Kleinpeter

    2009-01-01

    This dissertation is a historical biography on the life, suffrage and educational contributions of Mary Carroll Craig Bradford, a wife, mother, suffragist, teacher and educational administrator in the state of Colorado. The purpose of this dissertation was to find out exactly what Bradford's contributions were to her state. The initial observation…

  1. Women's Emancipation through Education: The Radical Agenda of Mary Wollstonecraft (1759-1797).

    ERIC Educational Resources Information Center

    Roberts, Leonard H.; Pollman, Mary Jo

    Two hundred years ago, Mary Wollstonecraft, the English women's rights pioneer, published her immortal work: "A Vindication of the Rights of Woman." In it she placed much of the blame for women's inferior political, intellectual, and social status on "faulty education." In "Vindication," she offered a number of…

  2. Bathymetric Survey and Storage Capacity of Upper Lake Mary near Flagstaff, Arizona

    USGS Publications Warehouse

    Hornewer, Nancy J.; Flynn, Marilyn E.

    2008-01-01

    Upper Lake Mary is a preferred drinking-water source for the City of Flagstaff, Arizona. Therefore, storage capacity and sedimentation issues in Upper Lake Mary are of interest to the City. The U.S. Geological Survey, in cooperation with the City of Flagstaff, collected bathymetric and land-survey data in Upper Lake Mary during late August through October 2006. Water-depth data were collected using a single-beam, high-definition fathometer. Position data were collected using real-time differential global position system receivers. Data were processed using commercial software and imported into geographic information system software to produce contour maps of lakebed elevations and for the computation of area and storage-capacity information. At full pool (spillway elevation of 6,828.5 feet above mean sea level), Upper Lake Mary has a storage capacity of 16,300 acre-feet, a surface area of 939 acres, a mean depth of 17.4 feet, and a depth near the dam of 39 feet. It is 5.6 miles long and varies in width from 308 feet near the central, narrow portion of the lake to 2,630 feet in the upper portion. Comparisons between this survey and a previous survey conducted in the 1950s indicate no apparent decrease in reservoir area or storage capacity between the two surveys.

  3. Rediscovering the Art of Developmental Therapy: An Interview with Mary M. Wood

    ERIC Educational Resources Information Center

    Teagarden, James M.; Kaff, Marilyn S.; Zabel, Robert H.

    2013-01-01

    Dr. Mary Margaret Wood is best known for developing psychoeducational programs that integrate mental health and special education interventions for children with emotional and behavioral disorders (EBD). Developmental Therapy (DT) includes comprehensive assessment of student behavior, communication, social, and cognitive development,…

  4. A Boolean Anthology. Selected Writings of Mary Boole - on Mathematical Education.

    ERIC Educational Resources Information Center

    Tahta, D. G., Comp.

    This volume is intended to provide a brief introduction to Mary Boole's writings. Short selections from her writings are organized under four areas: on teaching and learning, some mathematical lessons, the nature of mathematics, and the work of George Boole. A brief biography is also included. (DT)

  5. Novels, Thought Experiments, and Humanist Sociology in the Classroom: Mari Sandoz and CAPITAL CITY.

    ERIC Educational Resources Information Center

    Hill, Michael R.

    1987-01-01

    Based upon the teaching of Mari Sandoz' allegorical novel, CAPITAL CITY, this article identifies the characteristics of novels which provide a sociologically useful humanist perspective. A key characteristic is the extent to which the novel conducts thought experiments, defined as cerebral exercises which explore alternative social futures based…

  6. Saint Mary's College Teacher Science Institute: Converting Teachers to Using Guided Inquiry for Science Curricula

    ERIC Educational Resources Information Center

    McCarthy, Deborah; Bellina, Joseph J., Jr.

    2003-01-01

    In 1988 Saint Mary's College received a grant from Lilly Endowment, Inc. to create a program to improve the quality of science education in the local public and private schools. As part of applying that grant we created one-week summer work-shops for elementary and middle school teachers (K-8) based on guided inquiry methods of education. Each…

  7. Making Socialists: Mary Bridges Adams and the Fight for Knowledge and Power, 1855-1939

    ERIC Educational Resources Information Center

    Weiler, Kathleen

    2012-01-01

    This article presents a review of "Making socialists: Mary Bridges Adams and the fight for knowledge and power, 1855-1939," by Jane Martin. Jane Martin has explored the history of late-nineteenth-century and early-twentieth century-British women educational activists in numerous publications over the past two decades. Her first book,…

  8. Mary S. Peake and Charlotte F. Forten: Black Teachers during the Civil War and Reconstruction

    ERIC Educational Resources Information Center

    Taylor, Kay Ann

    2005-01-01

    The teaching lives of Mary S. Peake and Charlotte L. Forten during the Civil War and Reconstruction through a limited life history approach are examined. It is a contribution to the roles of African American women in the history of American education.

  9. Life as the Middle Child: A Conversation With Mary Margaret Kerr

    ERIC Educational Resources Information Center

    Teagarden, James M.; Zabel, Robert H.; Kaff, Marilyn S.

    2015-01-01

    As part of an ongoing oral history project, a conversation was held with Dr. Mary Margaret Kerr on the past, present, and possible future of the field of providing services to children with emotional-behavioral disorders. Dr. Wood stresses the increasing importance of providing an interdisciplinary approach to meet the needs for children or, as…

  10. Re-Birthing the Monstrous: James Whale's (Mis)Reading of Mary Shelley's "Frankenstein."

    ERIC Educational Resources Information Center

    Picart, Caroline Joan S.

    1998-01-01

    Contributes to scholarship on film and feminism by showing how James Whale's film attempts to excise or severely delimit the disturbing critique of the Romantic politics of gender in Mary Shelley's novel "Frankenstein." Discusses parthenogenesis, showing how the novel critiques the Romantic rhetorical reconstructions of masculine…

  11. Chaos M-ary modulation and demodulation method based on Hamilton oscillator and its application in communication.

    PubMed

    Fu, Yongqing; Li, Xingyuan; Li, Yanan; Yang, Wei; Song, Hailiang

    2013-03-01

    Chaotic communication has aroused general interests in recent years, but its communication effect is not ideal with the restriction of chaos synchronization. In this paper a new chaos M-ary digital modulation and demodulation method is proposed. By using region controllable characteristics of spatiotemporal chaos Hamilton map in phase plane and chaos unique characteristic, which is sensitive to initial value, zone mapping method is proposed. It establishes the map relationship between M-ary digital information and the region of Hamilton map phase plane, thus the M-ary information chaos modulation is realized. In addition, zone partition demodulation method is proposed based on the structure characteristic of Hamilton modulated information, which separates M-ary information from phase trajectory of chaotic Hamilton map, and the theory analysis of zone partition demodulator's boundary range is given. Finally, the communication system based on the two methods is constructed on the personal computer. The simulation shows that in high speed transmission communications and with no chaos synchronization circumstance, the proposed chaotic M-ary modulation and demodulation method has outperformed some conventional M-ary modulation methods, such as quadrature phase shift keying and M-ary pulse amplitude modulation in bit error rate. Besides, it has performance improvement in bandwidth efficiency, transmission efficiency and anti-noise performance, and the system complexity is low and chaos signal is easy to generate.

  12. Spatially detailed quantification of metal loading for decision making: Metal mass loading to American fork and Mary Ellen Gulch, Utah

    USGS Publications Warehouse

    Kimball, B.A.; Runkel, R.L.

    2009-01-01

    Effective remediation requires an understanding of the relative contributions of metals from all sources in a catchment, and that understanding must be based on a spatially detailed quantification of metal loading. A traditional approach to quantifying metal loading has been to measure discharge and chemistry at a catchment outlet. This approach can quantify annual loading and the temporal changes in load, but does not provide the needed spatial detail to evaluate specific sources, which is needed to support remediation decisions. A catchment or massloading approach provides spatial detail by combining tracer-injection and synoptic-sampling methods to quantify loading. Examples of studies in American Fork, Utah, and its tributary Mary Ellen Gulch illustrate this different approach. The mass-loading study in American Fork treated Mary Ellen Gulch as a single inflow. From that point of view, Mary Ellen Gulch was one of the greatest sources of Fe, Mn, Zn, and colloidal Pb loads to American Fork. But when Mary Ellen Gulch was evaluated in a separate catchment study, the detailed locations of metal loading were identified, and the extent of metal attenuation upstream from the mouth of Mary Ellen Gulch was quantified. The net, instantaneous load measured at the mouth of Mary Ellen Gulch for remediation planning would greatly underestimate the contributions of principal sources within the catchment. Extending the detailed sampling downstream from Mary Ellen Gulch indicated the possibility of diffuse groundwater inflow from Mary Ellen Gulch to American Fork. Comparing loads for Mary Ellen Gulch in the two studies indicates that metal loads could be substantially underestimated for planning purposes without the detailed catchment approach for the low-flow conditions in these studies. A mass-loading approach provides both the needed quantification of metal loading and the spatial detail to guide remediation decisions that would be the most effective in the catchments

  13. Late Holocene Deglaciation of Marie Byrd Land, West Antarctica

    NASA Astrophysics Data System (ADS)

    Stone, J. O.; Balco, G.; Sugden, D. E.; Caffee, M.; Siddoway, C.; Sass, L.; Cowdery, S.

    2001-12-01

    The deglaciation history of West Antarctica provides a long-term record of West Antarctic ice sheet dynamics on timescales that are difficult to address observationally or by modeling. By dating moraine deposits stranded on mountain flanks as the ice sheet thinned, we are reconstructing the deglaciation history of a 70 km transect along the Boyd Glacier, in the Ford Ranges, Marie Byrd Land. Fresh erratics and abraded bedrock extend to summit level on most nunataks, indicating that these were overrun by ice during the last glaciation. Conversely, high summits near the coast are more intensely weathered than lower-lying peaks, and one erratic from this weathered zone gives a cosmogenic Be-10 exposure age of 103 ka, suggesting (though it does not prove) that these peaks stood above the surface of the glacial maximum ice sheet. If so, the age of an erratic immediately below the weathering boundary, 10.4 +/- 0.7 ka, dates the glacial maximum in the Ford Ranges. All other erratics, from glaciated surfaces at lower elevation, give younger exposure ages. Summit erratics from Mt Blades, Mt Passel and an unnamed nunatak in the eastern Fosdick Mtns indicate that these peaks emerged from the ice sheet at 6.8 +/- 0.5 ka, 3.6 +/- 0.3 ka, and 4.7 +/- 0.4 ka, respectively. Subsequent downwasting rates, inferred from the decrease in exposure ages with elevation on these mountains, were between 5 and 10 cm per year. The youngest age obtained so far, 590 +/- 70 years, comes from an erratic on the lower slopes of Mt Rea, 100-150 m above the Arthur and Boyd Glaciers. From these results we can draw the following conclusions about West Antarctic Ice Sheet (WAIS) deglaciation in the Ford Ranges: (i) Most thinning of the WAIS took place in the late Holocene. (ii) Therefore, recession post-dated climatic warming, which Antarctic ice cores indicate commenced at 20 ka, by 10-15 kyr. (iii) Recession post-dated all but the final stages of global eustatic sea level rise. The ice sheet grounding

  14. Natural history of Charcot-Marie-Tooth disease during childhood.

    PubMed

    Cornett, Kayla M D; Menezes, Manoj P; Shy, Rosemary R; Moroni, Isabella; Pagliano, Emanuela; Pareyson, Davide; Estilow, Timothy; Yum, Sabrina W; Bhandari, Trupti; Muntoni, Francesco; Laura, Matilde; Reilly, Mary M; Finkel, Richard S; Eichinger, Kate J; Herrmann, David N; Bray, Paula; Halaki, Mark; Shy, Michael E; Burns, Joshua

    2017-09-01

    To determine the rate of disease progression in a longitudinal natural history study of children with Charcot-Marie-Tooth (CMT) disease. Two hundred six (103 female) participants aged 3 to 20 years enrolled in the Inherited Neuropathies Consortium were assessed at baseline and 2 years. Demographic, anthropometric, and diagnostic information were collected. Disease progression was assessed with the CMT Pediatric Scale (CMTPedS), a reliable Rasch-built linearly weighted disability scale evaluating fine and gross motor function, strength, sensation, and balance. On average, CMTPedS Total scores progressed at a rate of 2.4 ± 4.9 over 2 years (14% change from baseline; p < 0.001). There was no difference between males and females (mean difference, 0.5; 95% confidence interval [CI], -0.9 to 1.9; p = 0.49). The most responsive CMTPedS items were dorsiflexion strength (z-score change, -0.3; 95% CI, -0.6 to -0.05; p = 0.02), balance (z-score change, -1.0; 95% CI, -1.9 to -0.09; p = 0.03), and long jump (z-score change, -0.4; 95% CI, -0.7 to -0.02; p = 0.04). Of the most common genetic subtypes, 111 participants with CMT1A/PMP22 duplication progressed by 1.8 ± 4.2 (12% change from baseline; p < 0.001), 9 participants with CMT1B/MPZ mutation progressed by 2.2 ± 5.1 (11% change), 6 participants with CMT2A/MFN2 mutation progressed by 6.2 ± 7.9 (23% change), and 7 participants with CMT4C/SH3TC2 mutations progressed by 3.0 ± 4.5 (12% change). Participants with CMT2A progressed faster than CMT1A (mean difference, -4.4; 95% CI, -8.1 to -0.8; p = 0.02). Children with CMT1A progressed consistently through early childhood (3-10 years) and adolescence (11-20 years; mean difference, 1.1; 95% CI, -0.6 to 2.7; p = 0.19), whereas CMT2A appeared to progress faster during early childhood than adolescence (mean difference, 10.0; 95% CI, -2.2 to 22.2; p = 0.08). Using the CMTPedS as an outcome measure of disease severity, children

  15. Phenotypic variability of childhood Charcot-Marie-Tooth disease

    PubMed Central

    Cornett, KMD; Menezes, MP; Bray, P; Halaki, M; Shy, R; Yum, SW; Estilow, T; Moroni, I; Foscan, M; Pagliano, E; Pareyson, D; Laura, M; Bandhari, T; Muntoni, F; Reilly, MM; Finkel, RS; Sowden, J; Eichinger, K; Herrmann, DN; Shy, ME; Burns, J

    2016-01-01

    Importance Disease severity of childhood Charcot-Marie-Tooth disease (CMT) has not been extensively characterised, either within or between CMT types. Objective To assess the variability of disease severity in a large pediatric cohort of CMT. Design Cross-sectional study. Setting Conducted at eight universities and hospitals involved in the Inherited Neuropathies Consortium between August 2009 and July 2014 in Australia, Italy, UK and USA. Participants 520 children and adolescents with CMT aged 3–20 years. Main Outcome and Measure(s) The CMT Pediatric Scale (CMTPedS) which is a well-validated unidimensional clinical outcome measure to assess disease severity. It includes 11 items assessing fine and gross motor function, sensation and balance to produce a total score ranging from 0 (unaffected) to 44 (severely affected). Results CMT1A (54%), CMT2A (6%), CMT1B (3%), CMT4C (3%) and CMTX1 (2%) were the most prevalent CMT subtypes. Disease severity ranged from 1–44 CMTPedS points (mean 21.5±8.9) with ankle dorsiflexion strength and functional hand dexterity test items being most affected. Participants with CMT1B (24.0±7.4, range 13–42), CMT2A (29.7±7.1, range 14–44) and CMT4C (29.8±8.6, range 15–40) were more severely affected than CMT1A (18.9±7.7, range 1–40) and CMTX1 (males:15.3±7.7, range 4–27; females:13.0±3.6, range 9–16) (p<0.05). CMTPedS tended to worsen principally during childhood (3–10 years) for CMT4C and CMTX1, and worsen predominantly during adolescence for CMT1B and CMT2A (11–20 years), while CMT1A worsened consistently throughout childhood and adolescence. At an item level, participants with CMT4C recorded more affected functional dexterity test scores than all other types (p<0.05). Participants with CMT1A and CMTX1 performed significantly better in the nine hole peg test and balance than all other types (p<0.05). Participants with CMT2A had the weakest grip strength (p<0.05), while CMT2A and CMT4C exhibited the weakest ankle

  16. Pain assessment in Charcot-Marie-Tooth (CMT) disease.

    PubMed

    Ribiere, C; Bernardin, M; Sacconi, S; Delmont, E; Fournier-Mehouas, M; Rauscent, H; Benchortane, M; Staccini, P; Lantéri-Minet, M; Desnuelle, C

    2012-04-01

    The objective of our study was to describe and evaluate the prevalence of chronic pain in persons with Charcot-Marie-Tooth (CMT) disease during a multidisciplinary consultation at the Center of Reference for Neuromuscular Diseases. This prospective study was conducted between 2008 and 2010, it was a partnership between a Center of Reference for Neuromuscular Diseases (Centre de référence des maladies neuromusculaires [CRMD]) and a Department for the Assessment and Treatment of Pain (Département d'évaluation et de traitement de la douleur [DETD]). The evaluation consisted in a complete assessment of each patient during the first multidisciplinary consultation, with a previously established diagnosis validated by genetic testing, by various specialists: neurologist, PM&R physician, pain management specialist and physiotherapist. The evaluation tools used were Visual Analogical Scale (VAS), Hospital Anxiety and Depression Scale (HAD), DN4 scale, Neuropathic Pain Symptom Inventory (NPSI) (if DN4≥4), Pain Questionnaire of Saint Antoine (QDSA) (if DN4<4), body representation to define the painful areas, Overall Neuropathy Limitations Scale (ONLS), Medical Research Council scale (MRC), Short Questionnaire on Pain (QCD), VAS during transfers, self-care, getting dressed and physiotherapy sessions and quantified use of analgesics. A total of 50 patients were included (28 women, 22 men); two patients (one man and one woman) were discarded from the study because of missing pain assessment data. Mean age was 47years (R: 14-85), in average the symptoms had been present for the past 20years (R: 0.3-68), most patients had little impairment, the mean MRC was 53 (R: 36-60), with CMT1A being predominant (CMT1A: 76.9%, CMTX: 13.5%, CMT2: 5.8%, CMT4: 3.8%). It is noted that 65.4% of patients reported some pain with a mean duration of pain at 140months (R: 5-660). The mean VAS was 5.5 (R: 1-10), greater than 4 in 79.4% of cases, requiring the use of analgesics in 38.4% of cases

  17. Public archaeological interpretation on the campus of St. Mary's College of Maryland

    NASA Astrophysics Data System (ADS)

    Horrom, Alexander Michael

    2011-12-01

    Communicating archaeological findings to non-archaeologists is one of the most important and challenging aspects of the discipline. Archaeologists must serve multiple publics, bring communities into the archaeological process, and effectively disseminate information in order for their work to achieve relevance in the modern world. Communication with the public can take many forms, and brings together aspects of historic preservation, dialogic interpretation, applied critical archaeology, heritage, and landscape studies. This dissertation analyzes public interpretation at St. Mary's City, Maryland, a multi-component historic landscape containing historic and prehistoric sites from various time periods and proposes measures to be taken there to better engage the public. This site presents a unique context for public interpretation: the Historic St. Mary's City archaeological museum occupies a portion of the landscape, while neighboring St. Mary's College of Maryland is a public collegiate campus that contains an imposing number of uninterpreted sites. Exploration of the histories and relationships between these institutions provide insight into the many factors which impact public interpretation. Examination of this case includes identifying audiences, gauging attitudes towards archaeology, assessing current interpretive measures, and identifying areas where public engagement can be improved. The example of St. Mary's outlines how an individual's relationship to archaeology is interwoven into their experience of the landscape. The past and present coexist on historic landscapes, and public communication can use this juxtaposition to engage audiences in meaningful ways. I conclude by developing an archaeological walking tour of the St. Mary's landscape aimed at creating discussion and making people aware of the sites around them.

  18. Mutations in the MORC2 gene cause axonal Charcot-Marie-Tooth disease.

    PubMed

    Sevilla, Teresa; Lupo, Vincenzo; Martínez-Rubio, Dolores; Sancho, Paula; Sivera, Rafael; Chumillas, María J; García-Romero, Mar; Pascual-Pascual, Samuel I; Muelas, Nuria; Dopazo, Joaquín; Vílchez, Juan J; Palau, Francesc; Espinós, Carmen

    2016-01-01

    Charcot-Marie-Tooth disease (CMT) is a complex disorder with wide genetic heterogeneity. Here we present a new axonal Charcot-Marie-Tooth disease form, associated with the gene microrchidia family CW-type zinc finger 2 (MORC2). Whole-exome sequencing in a family with autosomal dominant segregation identified the novel MORC2 p.R190W change in four patients. Further mutational screening in our axonal Charcot-Marie-Tooth disease clinical series detected two additional sporadic cases, one patient who also carried the same MORC2 p.R190W mutation and another patient that harboured a MORC2 p.S25L mutation. Genetic and in silico studies strongly supported the pathogenicity of these sequence variants. The phenotype was variable and included patients with congenital or infantile onset, as well as others whose symptoms started in the second decade. The patients with early onset developed a spinal muscular atrophy-like picture, whereas in the later onset cases, the initial symptoms were cramps, distal weakness and sensory impairment. Weakness and atrophy progressed in a random and asymmetric fashion and involved limb girdle muscles, leading to a severe incapacity in adulthood. Sensory loss was always prominent and proportional to disease severity. Electrophysiological studies were consistent with an asymmetric axonal motor and sensory neuropathy, while fasciculations and myokymia were recorded rather frequently by needle electromyography. Sural nerve biopsy revealed pronounced multifocal depletion of myelinated fibres with some regenerative clusters and occasional small onion bulbs. Morc2 is expressed in both axons and Schwann cells of mouse peripheral nerve. Different roles in biological processes have been described for MORC2. As the silencing of Charcot-Marie-Tooth disease genes have been associated with DNA damage response, it is tempting to speculate that a deregulation of this pathway may be linked to the axonal degeneration observed in MORC2 neuropathy, thus adding a

  19. Mobile applications for participation at the shopping mall: content analysis and usability for persons with physical disabilities and communication or cognitive limitations.

    PubMed

    Auger, Claudine; Leduc, Emilie; Labbé, Delphine; Guay, Cassioppée; Fillion, Brigitte; Bottari, Carolina; Swaine, Bonnie

    2014-12-01

    The aim of this exploratory study was to determine the important features in content and usability of existing mobile applications evaluating environmental barriers and facilitators (EBF) to participation for persons with physical disabilities presenting mild communication or cognitive limitations. A rigorous process based on a user-centered design approach led to the identification of two relevant mobile applications to evaluate the EBF. An accessibility expert, the research team as well as five users then tested the mobile applications in a shopping mall. A thematic content analysis of the research team's and users' comments established 10 categories of key features that adequately respond to the needs of the clientele targeted in this study. In terms of content, granularity and contextualization of the information provided were considered important. With respect to usability, relevant features were place finding, rating system, presentation of results, compatibility, user-friendliness, aesthetics, credibility of the information as well as connectivity/interactiveness. The research team and the users agreed on some aspects such as aesthetics, but had different perspectives on features such as the rating system or the connectivity/interactiveness of the application. The users proposed new features suggesting that the existing mobile applications did not correspond to all their needs.

  20. Rehabilitation Living Lab in the Mall Community of Practice: Learning Together to Improve Rehabilitation, Participation and Social Inclusion for People Living with Disabilities

    PubMed Central

    Mazer, Barbara; Kairy, Dahlia; Guindon, Andréanne; Girard, Michel; Swaine, Bonnie; Kehayia, Eva; Labbé, Delphine

    2015-01-01

    Communities of practice (CoP) can facilitate collaboration between people who share a common interest, but do not usually work together. A CoP was initiated and developed including stakeholders from clinical, research, community and governmental backgrounds involved in a large multidisciplinary and multi-sectorial project: the Rehabilitation Living Lab in a Mall (RehabMaLL). This study aimed to evaluate the structure, process and outcomes of this CoP. A single case-study, using mixed-methods, evaluated the RehabMaLL CoP initiative after one year, based on Donabedian’s conceptual evaluation model. Forty-three participants took part in the RehabMaLL CoP with 60.5% (n = 26) participating at least once on the online platform where 234 comments were posted. Four in-person meetings were held. Members expressed satisfaction regarding the opportunity to share knowledge with people from diverse backgrounds and the usefulness of the CoP for the RehabMaLL project. Collaboration led to concrete outcomes, such as a sensitization activity and a research project. Common challenges included lack of time and difficulty finding common objectives. A CoP can be a useful strategy to facilitate knowledge sharing on disability issues. Future research is necessary to determine strategies of increasing knowledge creation between members. PMID:25913187

  1. Mobile Applications for Participation at the Shopping Mall: Content Analysis and Usability for Persons with Physical Disabilities and Communication or Cognitive Limitations

    PubMed Central

    Auger, Claudine; Leduc, Emilie; Labbé, Delphine; Guay, Cassioppée; Fillion, Brigitte; Bottari, Carolina; Swaine, Bonnie

    2014-01-01

    The aim of this exploratory study was to determine the important features in content and usability of existing mobile applications evaluating environmental barriers and facilitators (EBF) to participation for persons with physical disabilities presenting mild communication or cognitive limitations. A rigorous process based on a user-centered design approach led to the identification of two relevant mobile applications to evaluate the EBF. An accessibility expert, the research team as well as five users then tested the mobile applications in a shopping mall. A thematic content analysis of the research team’s and users’ comments established 10 categories of key features that adequately respond to the needs of the clientele targeted in this study. In terms of content, granularity and contextualization of the information provided were considered important. With respect to usability, relevant features were place finding, rating system, presentation of results, compatibility, user-friendliness, aesthetics, credibility of the information as well as connectivity/interactiveness. The research team and the users agreed on some aspects such as aesthetics, but had different perspectives on features such as the rating system or the connectivity/interactiveness of the application. The users proposed new features suggesting that the existing mobile applications did not correspond to all their needs. PMID:25513999

  2. National Dam Inspection Program. St. Mary’s River Watershed, Site Number 1, (NDI-ID Number MD-28) Potomac River Basin, Western Branch of St. Mary’s River, St. Mary’s County, Maryland. Phase I Inspection Report,

    DTIC Science & Technology

    1980-07-01

    storm frequency is assigned to the 11.5 inches of rainfall. Using the 11,700 cfs rate, the maximum design high water level was established at an eleva...THE COPY FURNISHED TO DTIC CONTAINED A SIGNIFICANT NUMBER OF PAGES WHICH DO NOT REPRODUCE LEGIBLY. JPTOX4C JIVER BAS! 5 f ESTERN)RANCH OF ST. MARY’S...River Watershed, Site No. I NDI ID NO. MD-28 Size: Intermediate (9600 acre-feet, 38 feet high ) Hazard Classification: High Owner: State of Maryland

  3. ALS5/SPG11/KIAA1840 mutations cause autosomal recessive axonal Charcot-Marie-Tooth disease.

    PubMed

    Montecchiani, Celeste; Pedace, Lucia; Lo Giudice, Temistocle; Casella, Antonella; Mearini, Marzia; Gaudiello, Fabrizio; Pedroso, José L; Terracciano, Chiara; Caltagirone, Carlo; Massa, Roberto; St George-Hyslop, Peter H; Barsottini, Orlando G P; Kawarai, Toshitaka; Orlacchio, Antonio

    2016-01-01

    Charcot-Marie-Tooth disease is a group of hereditary peripheral neuropathies that share clinical characteristics of progressive distal muscle weakness and atrophy, foot deformities, distal sensory loss, as well as diminished tendon reflexes. Hundreds of causative DNA changes have been found, but much of the genetic basis of the disease is still unexplained. Mutations in the ALS5/SPG11/KIAA1840 gene are a frequent cause of autosomal recessive hereditary spastic paraplegia with thin corpus callosum and peripheral axonal neuropathy, and account for ∼ 40% of autosomal recessive juvenile amyotrophic lateral sclerosis. The overlap of axonal Charcot-Marie-Tooth disease with both diseases, as well as the common autosomal recessive inheritance pattern of thin corpus callosum and axonal Charcot-Marie-Tooth disease in three related patients, prompted us to analyse the ALS5/SPG11/KIAA1840 gene in affected individuals with autosomal recessive axonal Charcot-Marie-Tooth disease. We investigated 28 unrelated families with autosomal recessive axonal Charcot-Marie-Tooth disease defined by clinical, electrophysiological, as well as pathological evaluation. Besides, we screened for all the known genes related to axonal autosomal recessive Charcot-Marie-Tooth disease (CMT2A2/HMSN2A2/MFN2, CMT2B1/LMNA, CMT2B2/MED25, CMT2B5/NEFL, ARCMT2F/dHMN2B/HSPB1, CMT2K/GDAP1, CMT2P/LRSAM1, CMT2R/TRIM2, CMT2S/IGHMBP2, CMT2T/HSJ1, CMTRID/COX6A1, ARAN-NM/HINT and GAN/GAN), for the genes related to autosomal recessive hereditary spastic paraplegia with thin corpus callosum and axonal peripheral neuropathy (SPG7/PGN, SPG15/ZFYVE26, SPG21/ACP33, SPG35/FA2H, SPG46/GBA2, SPG55/C12orf65 and SPG56/CYP2U1), as well as for the causative gene of peripheral neuropathy with or without agenesis of the corpus callosum (SLC12A6). Mitochondrial disorders related to Charcot-Marie-Tooth disease type 2 were also excluded by sequencing POLG and TYMP genes. An additional locus for autosomal recessive Charcot-Marie

  4. Mitochondrial DNA analysis on remains of a putative son of Louis XVI, King of France and Marie-Antoinette.

    PubMed

    Jehaes, E; Decorte, R; Peneau, A; Petrie, J H; Boiry, P A; Gilissen, A; Moisan, J P; Van den Berghe, H; Pascal, O; Cassiman, J J

    1998-01-01

    Carl Wilhelm Naundorff was buried in 1845 in Delft as Louis Charles, Duc de Normandie, 'Louis XVII'. However, the son of Louis XVI and Marie-Antoinette-Louis XVII--officially died in the Temple of Paris in 1795. In order to resolve the identity of Naundorff, mitochondrial DNA (mtDNA) D-loop sequences of his remains were compared with the sequences obtained from the hairs of two sisters of Marie-Antoinette, Marie-Antoinette herself, and with the sequences obtained from DNA samples of two living maternal relatives. The mtDNA sequence of a bone sample from Naundorff showed two nucleotide differences from the sequences of the three sisters and four differences from the sequences of living maternal relatives. Based on this evidence it becomes very unlikely that Naundroff is the son of Marie-Antoinette.

  5. [Marie Curie, née Maria Sklodowska (1867-1934)--contribution to the development of radiology].

    PubMed

    Babić, Rade R; Babić, Gordana Stanković

    2011-01-01

    Marie Curie, née Maria Sklodowska, was born on November 7, 1867 in Warsaw (Poland). She suffered from leukaemia and died on June 4, 1934. She was buried with full honours at Pantheon. Marie Curie and her husband Pierre Curie discovered the radioactive elements Polonium (84Po210), Thorium (90Th232) and Radium (88Ra226). Marie Curie introduced the term radioactivity into science. She was the first woman who got Ph.D. in France, the first woman professor at Sorbonne, Paris and Medical Academy. Of all the women who have ever won the Nobel Prize, Marie Curie was the only who received it twice. During World War I Marie Curie designed a mobile x-ray room "radiologic car". Marie Curie had an x-ray machine installed into a car and demonstrated how to use its dynamo for electric power production necessary for the x-ray machine to work. She had 20 cars with moving radiological lab made and trained 150 people to work on them. She brought something radically new into military medicine--mobile x-ray diagnostics. With the discovery of radioactive elements a new medical branch, radiotherapy, was developed.

  6. Concept And Its Implementation During The Reconstruction Of The Church Of Blessed Virgin Mary In Chojna

    NASA Astrophysics Data System (ADS)

    Płotkowiak, Maciej

    2015-12-01

    St. Mary's parish church in Chojna was erected at the turn of XIV and XVc. in a shape of three aisles, hall church without transept, completed from the west with a single tower and from the east with polygonal presbytery with an ambulatory attached. The convergence of characteristic structural and decorative features with employed ones in medieval churches being attributed to Hinrich Brunsberg's fabric resulted in such a way, that also authorship of St. Mary in Chojna was assigned to this legendary architect and master builder of late Middle Ages period. The church was destroyed by fire during WWII in February 1945 and since then had remained as an open ruin. In 1997 reconstruction procedure of the church was begun under the leadership of the author and it still continues. This text consists of the sum of experiences connected with confronting design ideas and solutions with their executions on the site during construction works.

  7. Reversible Foix-Chavany-Marie Syndrome in a patient treated for hydrocephalus.

    PubMed

    Kaloostian, P; Chen, H; Harrington, H

    2012-10-01

    The authors report the first known case of Foix-Chavany-Marie Syndrome in a patient with hydrocephalus that reversed with ventriculoperitoneal shunting. A 34-year-old x-ray technician with a history of pilocytic astrocytoma resection and radiotherapy and ventriculoperitoneal shunt placement as a child presented with altered mental status and nausea. She was found to have acute hydrocephalus. Post-operatively she did well and was discharged home. The next day she became acutely altered with anarthria, difficulty speaking, and stiff facial muscles. After multiple revisions, she slowly recovered to her pre-op baseline over the course of next 2 months. This is the first known case of acute hydrocephalus causing Foix-Chavany-Marie Syndrome. Additionally, we show that this unique syndrome is slowly reversible after treatment of hydrocephalus.

  8. De Novo duplication in Charcot-Marie-Tooth Type 1A

    SciTech Connect

    Mandich, P.; Bellone, E.; Ajmar, F.

    1996-09-01

    We read with interest the paper on {open_quotes}Prevalence and Origin of De Novo Duplications in Charcot-Marie-Tooth Disease Type 1A: First Report of a De Novo Duplication with a Maternal Origin,{close_quotes}. They reported their experience with 10 sporadic cases of Charcot-Marie-Tooth type 1A (CMT1A) in which it was demonstrated that the disease had arisen as the result of a de novo duplication. They analyzed the de novo-duplication families by using microsatellite markers and identified the parental origin of the duplication in eight cases. In one family the duplication was of maternal origin, whereas in the remaining seven cases it was of paternal origin. The authors concluded that their report was the first evidence of a de novo duplication of maternal origin, suggesting that this is not a phenomenon associated solely with male meiosis. 7 refs.

  9. Variation amongst protoplast-derived potato plants (Solatium tuberosum cv. 'Maris Bard').

    PubMed

    Thomas, E; Bright, S W; Franklin, J; Lancaster, V A; Miflin, B J; Gibson, R

    1982-03-01

    Plants were obtained from protoplasts of shoot cultures of potato (Solarium tuberosum L. cv. 'Maris Bard') and from in situ calluses upon plants of cv. 'Majestic'. None of the protoplast-derived plants resembled each other in all of ten morphological characteristics scored and only one resembled the parental 'Maris Bard' type. As there were a number of plants regenerated from each of ten protoplast-derived calluses it is concluded that variation arose after protoplast isolation during the cell culture phase. Plants regenerated from in situ calluses of cv. 'Majestic' were quite uniform. Reported cases of variation and uniformity from cultured potato tissues are discussed. It is concluded that the variation is not a consequence of using protoplasts and that the expression or induction of variation is controllable.

  10. GPS evidence for a coherent Antarctic plate and for postglacial rebound in Marie Byrd Land

    NASA Astrophysics Data System (ADS)

    Donnellan, Andrea; Luyendyk, Bruce P.

    2004-07-01

    GPS measurements collected between 1999 and 2002 in Marie Byrd Land, West Antarctica indicate no significant present motion between East and West Antarctica greater than 1-2 mm/year. Low strain rates imply that the Ross Sea rift is either inactive or active at a very low rate. This result indicates that the two subcontinents are likely joined as a single coherent lithospheric plate. They could have been joined since the end of Adare Trough spreading in Oligocene time. The volcanic activity in the Ross Sea sector at present such as at Mount Erebus is most likely related to mantle upwelling and not associated with continental rifting. GPS measurements of vertical rates indicate postglacial rebound of up to 12±4 mm/year in western Marie Byrd Land (wMBL). Errors are scaled 1 σ. The rock uplift rates are consistent with postglacial rebound models of significant ice thinning in the eastern Ross Ice Shelf in the late Holocene.

  11. Mining Cultures and Mary Cults: Where the Sacred and Profane Meet.

    PubMed

    Munday, Pat

    2016-01-01

    Our Lady of the Rockies (OLR) is a ninety-foot-tall statue of the Virgin Mary overlooking Butte, Montana, from its perch high atop the Continental Divide. In the popularized account, OLR is a uniquely local undertaking reflecting the community's character and pride. Yet OLR is far more than this, for it taps into a rich vein of cultural and spiritual tradition. As Mircea Eliade pointed out, the notion of the earth as female pervaded early Western civilizations. Mines were like the vagina of the earth, leading to the womb where metallic ores waxed like embryos. Accordingly, miners purified themselves through various rites to amend their violation. OLR began as a plan for a small, private altar. With the collapse of Butte's copper mining economy, unemployed miners rallied around the idea of building a major shrine to the Virgin Mary that would help restore the city's culture and economy.

  12. The research school of Marie Curie in the Paris faculty, 1907-14.

    PubMed

    Davis, J L

    1995-07-01

    As the most famous woman scientist of the twentieth century, there has been no shortage of books and articles on the life and career of Marie Curie (1867-1934). Her role as director of a laboratory-based research school in the new scientific field of radioactivity, a field which embraced both chemistry and physics, however, has never been examined. In recent years, there has been a growing interest in the question of research schools, and Morrell, Ravetz, Geison, and Klosterman, amongst others, have written on this subject. Using, in part, the methodology of Morrell, this paper investigates the role of Marie Curie as a school director in the Paris Faculty in the years 1907-14, examining the work and characteristics of her school and assessing her effectiveness as a director.

  13. The ties that bind: Soil surveyor William Edgar Tharp and oceanographic cartographer Marie Tharp

    NASA Astrophysics Data System (ADS)

    Landa, Edward R.

    The link between soil science and geology is personified in the American father and daughter: soil surveyor William Edgar Tharp (1870-1959) and oceanographic cartographer Marie Tharp (1920-2006). From 1904 to 1935, W.E. Tharp mapped soils in 14 states for the US Department of Agriculture, and campaigned during the late 1920s-early 1930s to raise awareness of the high rates of soil erosion from croplands. The lifestyle of the federal soil surveyor in the United States during the early 20th century involved frequent household moves, and it played a formative role in Marie Tharp’s childhood. Her path to a career in geology was molded by this family experience, by mentors encountered in the classroom, and by social barriers that faced women scientists of that era.

  14. A novel mutation in VCP causes Charcot-Marie-Tooth Type 2 disease.

    PubMed

    Gonzalez, Michael A; Feely, Shawna M; Speziani, Fiorella; Strickland, Alleene V; Danzi, Matt; Bacon, Chelsea; Lee, Youjin; Chou, Tsui-Fen; Blanton, Susan H; Weihl, Conrad C; Zuchner, Stephan; Shy, Michael E

    2014-11-01

    Mutations in VCP have been reported to account for a spectrum of phenotypes that include inclusion body myopathy with Paget's disease of the bone and frontotemporal dementia, hereditary spastic paraplegia, and 1-2% of familial amyotrophic lateral sclerosis. We identified a novel VCP mutation (p.Glu185Lys) segregating in an autosomal dominant Charcot-Marie-Tooth disease type 2 family. Functional studies showed that the Glu185Lys variant impaired autophagic function leading to the accumulation of immature autophagosomes. VCP mutations should thus be considered for genetically undefined Charcot-Marie-Tooth disease type 2. © The Author (2014). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  15. Charcot-Marie-Tooth disease masquerading as acute demyelinating encephalomyelitis-like illness.

    PubMed

    Kim, Gun-Ha; Kim, Kyoung Min; Suh, Sang-Il; Ki, Chang-Seok; Eun, Baik-Lin

    2014-07-01

    X-linked Charcot-Marie-Tooth disease (CMTX1) is a clinically heterogeneous hereditary motor and sensory neuropathy with X-linked transmission. Common clinical manifestations of CMTX1 disease, as in other forms of Charcot-Marie-Tooth (CMT) disease, are distal muscle wasting and weakness, hyporeflexia, distal sensory disturbance, and foot deformities. Mutations in the connexin-32 gene (gap junction protein β1 [GJB1]) are responsible for CMTX1 disease. In this report, we describe a patient with CMTX1 disease presenting with recurrent attacks of transient and episodic acute demyelinating encephalomyelitis (ADEM)-like symptoms without previous signs of lower extremity weakness or foot deformities; the patient, as well as his asymptomatic mother, exhibited a novel GJB1 mutation (p.Met1Ile). Differential diagnosis of recurrent and transient ADEM-like illness, if unexplained, should include the possibility of CMTX1 disease.

  16. 250 Years of Physics at the College of William and Mary: 1760-2010

    NASA Astrophysics Data System (ADS)

    von Baeyer, Hans

    2010-02-01

    The recorded history of physics at William and Mary begins when Thomas Jefferson, the College's most distinguished alumnus, meets his mentor, Dr. William Small of Scotland, who opens his eyes to the wonders of natural philosophy. After the vicissitudes of the Revolution and the Civil War, physics enjoys a revival in the twentieth century, culminating in the creation of a Ph.D. program in the 1960s and the building of the William Small Physical Laboratory in Williamsburg. In the 1980s the modern era is launched by the establishment of the US Department of Energy's Jefferson Lab for nuclear physics in nearby Newport News. Today both Small Hall and Jefferson Lab are in the process of renovation. The legacies of Small and Jefferson for physics at William and Mary are secure! )

  17. I Want to Believe: A Short Psychobiography of Mary Baker Eddy.

    PubMed

    Dean, Taylor Wilson

    2016-01-01

    The 18th and 19th centuries were beset with new religious movements in the United States: Shakers, Latter Day Saints, Millerites, and Seventh Day Adventists to name a few. One group, Christian Science, held radically different views than their counterparts and their origins lay in the most unlikely of places, a perpetually ill and poor woman from New Hampshire. Much has been said about Mary Baker Eddy: some say that she was a prophet, others that she was a fraud. Herein no such judgments are made. This study seeks to look into the life of Mary Baker Eddy from a psychological lens in the hopes that insight can be gained into the founding of the First Church of Jesus Christ Scientist and perhaps to allay the binary of Mrs. Eddy as either prophet or fanatic.

  18. Exploring variation-aware contig graphs for (comparative) metagenomics using MaryGold

    PubMed Central

    Nijkamp, Jurgen F.; Pop, Mihai; Reinders, Marcel J. T.; de Ridder, Dick

    2013-01-01

    Motivation: Although many tools are available to study variation and its impact in single genomes, there is a lack of algorithms for finding such variation in metagenomes. This hampers the interpretation of metagenomics sequencing datasets, which are increasingly acquired in research on the (human) microbiome, in environmental studies and in the study of processes in the production of foods and beverages. Existing algorithms often depend on the use of reference genomes, which pose a problem when a metagenome of a priori unknown strain composition is studied. In this article, we develop a method to perform reference-free detection and visual exploration of genomic variation, both within a single metagenome and between metagenomes. Results: We present the MaryGold algorithm and its implementation, which efficiently detects bubble structures in contig graphs using graph decomposition. These bubbles represent variable genomic regions in closely related strains in metagenomic samples. The variation found is presented in a condensed Circos-based visualization, which allows for easy exploration and interpretation of the found variation. We validated the algorithm on two simulated datasets containing three respectively seven Escherichia coli genomes and showed that finding allelic variation in these genomes improves assemblies. Additionally, we applied MaryGold to publicly available real metagenomic datasets, enabling us to find within-sample genomic variation in the metagenomes of a kimchi fermentation process, the microbiome of a premature infant and in microbial communities living on acid mine drainage. Moreover, we used MaryGold for between-sample variation detection and exploration by comparing sequencing data sampled at different time points for both of these datasets. Availability: MaryGold has been written in C++ and Python and can be downloaded from http://bioinformatics.tudelft.nl/software Contact: d.deridder@tudelft.nl PMID:24058058

  19. 2012 Existing Vegetation Plan Marie Zimmermann Farm, U.S. Route ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2012 Existing Vegetation Plan - Marie Zimmermann Farm, U.S. Route 209, 5 Miles Southwest of Milford. The property is defined at its northern boundary by Zimmermann Road and at the west by Long Meadow Road. The east boundary of the parcel is the edge of the Delaware River. The south edge of the parcel is irregularly oriented east-to-west. , Milford, Pike County, PA

  20. Exploring variation-aware contig graphs for (comparative) metagenomics using MaryGold.

    PubMed

    Nijkamp, Jurgen F; Pop, Mihai; Reinders, Marcel J T; de Ridder, Dick

    2013-11-15

    Although many tools are available to study variation and its impact in single genomes, there is a lack of algorithms for finding such variation in metagenomes. This hampers the interpretation of metagenomics sequencing datasets, which are increasingly acquired in research on the (human) microbiome, in environmental studies and in the study of processes in the production of foods and beverages. Existing algorithms often depend on the use of reference genomes, which pose a problem when a metagenome of a priori unknown strain composition is studied. In this article, we develop a method to perform reference-free detection and visual exploration of genomic variation, both within a single metagenome and between metagenomes. We present the MaryGold algorithm and its implementation, which efficiently detects bubble structures in contig graphs using graph decomposition. These bubbles represent variable genomic regions in closely related strains in metagenomic samples. The variation found is presented in a condensed Circos-based visualization, which allows for easy exploration and interpretation of the found variation. We validated the algorithm on two simulated datasets containing three respectively seven Escherichia coli genomes and showed that finding allelic variation in these genomes improves assemblies. Additionally, we applied MaryGold to publicly available real metagenomic datasets, enabling us to find within-sample genomic variation in the metagenomes of a kimchi fermentation process, the microbiome of a premature infant and in microbial communities living on acid mine drainage. Moreover, we used MaryGold for between-sample variation detection and exploration by comparing sequencing data sampled at different time points for both of these datasets. MaryGold has been written in C++ and Python and can be downloaded from http://bioinformatics.tudelft.nl/software

  1. Carbon Cycle 2.0: Mary Ann Piette: Impact of efficient buildings

    ScienceCinema

    Mary Ann Piette

    2016-07-12

    Mary Ann Piette speaks at the Carbon Cycle 2.0 kick-off symposium Feb. 2, 2010. We emit more carbon into the atmosphere than natural processes are able to remove - an imbalance with negative consequences. Carbon Cycle 2.0 is a Berkeley Lab initiative to provide the science needed to restore this balance by integrating the Labs diverse research activities and delivering creative solutions toward a carbon-neutral energy future. http://carboncycle2.lbl.gov/

  2. Refined genetic mapping of X-linked Charcot-Marie-Tooth neuropathy

    SciTech Connect

    Fain, P.R.; Barker, D.F.; Chance, P.F. )

    1994-02-01

    Genetic linkage studies were conducted in four multigenerational families with X-linked Charcot-Marie-Tooth disease (CMTX), using 12 highly polymorphic short-tandem-repeat markers for the pericentromeric region of the X Chromosome. Pairwise linkage analysis with individual markers confirmed tight linkage of CMTX to the pericentromeric region in each family. Multipoint analyses strongly support the order DXS337-CMTX-DXS441-(DXS56, PGK1). 38 refs., 2 figs., 1 tab.

  3. Mary Wollstonecraft Shelley's Frankenstein, or the modern Prometheus: a psychological study of unrepaired shame.

    PubMed

    Severino, Sally K; Morrison, Nancy K

    2013-01-01

    Mary Wollstonecraft Shelley's modern Prometheus shows us the eternal punishment of unrepaired shame--eternal entrapment within the shame triangle of victim, perpetrator and rescuer. This paper describes how Shelley's insight--that lack of love creates a monster living in shame--is being confirmed by neuroscience and how this is exemplified in two characters--the creature and Victor Frankenstein. Additionally, it delineates how pastoral counselors can help those suffering from unrepaired shame

  4. ["Professor is well". The correspondence between Max Schur and Marie Bonaparte].

    PubMed

    Stouten, Hanna

    2012-01-01

    The correspondence between Freud's doctor and his "Princess" spans the period 1929-1962, and comprises over 90 letters, mostly concerned with Freud's health but also touching upon Schur's permanent dilemma--to emigrate or to stay with Freud--and upon the dire situation of his family and friends on behalf of whom he appeals to Marie for help. After Freud's death the letters change in focus.

  5. Laparoscopic appendectomy in a pediatric patient with type 1 Charcot-Marie-Tooth disease.

    PubMed

    Heller, Joshua A; Marn, Richard Y

    2015-12-01

    A pediatric patient with type 1 Charcot-Marie-Tooth disease-a disorder associated with a demyelinating polyneuropathy-presented for laparoscopic appendectomy in the setting of acute appendicitis. Induction and maintenance of anesthesia were successfully managed without the use of any depolarizing or nondepolarizing neuromuscular blocking agents. The patient was successfully extubated at the completion of the procedure without any respiratory or neuromuscular sequelae, with excellent pain control and no postoperative nausea or vomiting.

  6. Carbon Cycle 2.0: Mary Ann Piette: Impact of efficient buildings

    SciTech Connect

    Mary Ann Piette

    2010-02-09

    Mary Ann Piette speaks at the Carbon Cycle 2.0 kick-off symposium Feb. 2, 2010. We emit more carbon into the atmosphere than natural processes are able to remove - an imbalance with negative consequences. Carbon Cycle 2.0 is a Berkeley Lab initiative to provide the science needed to restore this balance by integrating the Labs diverse research activities and delivering creative solutions toward a carbon-neutral energy future. http://carboncycle2.lbl.gov/

  7. 2012 Existing Landscape Plan Marie Zimmermann Farm, U.S. Route ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2012 Existing Landscape Plan - Marie Zimmermann Farm, U.S. Route 209, 5 Miles Southwest of Milford. The property is defined at its northern boundary by Zimmermann Road and at the west by Long Meadow Road. The east boundary of the parcel is the edge of the Delaware River. The south edge of the parcel is irregularly oriented east-to-west. , Milford, Pike County, PA

  8. 1972 Period Plan Marie Zimmermann Farm, U.S. Route 209, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1972 Period Plan - Marie Zimmermann Farm, U.S. Route 209, 5 Miles Southwest of Milford. The property is defined at its northern boundary by Zimmermann Road and at the west by Long Meadow Road. The east boundary of the parcel is the edge of the Delaware River. The south edge of the parcel is irregularly oriented east-to-west. , Milford, Pike County, PA

  9. 1935 Period Plan Marie Zimmermann Farm, U.S. Route 209, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1935 Period Plan - Marie Zimmermann Farm, U.S. Route 209, 5 Miles Southwest of Milford. The property is defined at its northern boundary by Zimmermann Road and at the west by Long Meadow Road. The east boundary of the parcel is the edge of the Delaware River. The south edge of the parcel is irregularly oriented east-to-west. , Milford, Pike County, PA

  10. The impact of ultra-brief chest compression-only CPR video training on responsiveness, compression rate, and hands-off time interval among bystanders in a shopping mall.

    PubMed

    Panchal, Ashish R; Meziab, Omar; Stolz, Uwe; Anderson, Wes; Bartlett, Mitchell; Spaite, Daniel W; Bobrow, Bentley J; Kern, Karl B

    2014-09-01

    Recent studies have demonstrated higher-quality chest compressions (CCs) following a 60 s ultra-brief video (UBV) on compression-only CPR (CO-CPR). However, the effectiveness of UBVs as a CPR-teaching tool for lay bystanders in public venues remains unknown. Determine whether an UBV is effective in teaching laypersons CO-CPR in a public setting and if viewing leads to superior responsiveness and CPR skills. Adult lay bystanders were enrolled in a public shopping mall and randomized to: (1) Control (CTR): sat idle for 60 s; (2) UBV: watched a 60 s UBV on CO-CPR. Subjects were read a scenario detailing a sudden collapse in the mall and asked to do what they "thought was best" on a mannequin. Performance measures were recorded for 2 min: responsiveness (time to call 911 and first CCs) and CPR quality [CC depth, rate, hands-off interval (time without CC after first CC)]. One hundred subjects were enrolled. Demographics were similar between groups. UBV subjects called 911 more frequently (percent difference: 31%) and initiated CCs sooner in the arrest scenario (median difference (MD): 5 s). UBV cohort had increased CC rate (MD: 19 cpm) and decreased hands-off interval (MD: 27 s). There was no difference in CC depth. Bystanders with UBV training in a shopping mall had significantly improved responsiveness, CC rate, and decreased hands-off interval. Given the short length of training, UBV may have potential as a ubiquitous intervention for public venues to help improve bystander reaction to arrest and CO-CPR performance. Published by Elsevier Ireland Ltd.

  11. XAS studies of the effectiveness of iron chelating treatments of Mary Rose timbers

    NASA Astrophysics Data System (ADS)

    Berko, A.; Smith, A. D.; Jones, A. M.; Schofield, E. J.; Mosselmans, J. F. W.; Chadwick, A. V.

    2009-11-01

    The oxidation of sulfur in marine archaeological timbers under museum storage conditions is a recently identified problem, particularly for major artefacts such as historic ships excavated from the seabed. Recent work on the Vasa has stressed the role of iron in catalysing the oxidative degradation of the wood cellulose and the polyethylene glycols used to restore mechanical integrity to the timbers. In developing new treatment protocols for the long term preservation of Henry VIII of England's flagship, the Mary Rose, we are investigating the potential of chelating agents to neutralise and remove the iron products from the ships timbers. We have explored the use of aqueous solutions of chelating agents of calcium phytate, ethylenediaminetetraacetic acid (EDTA), diethylenetriaminepentaacetic acid (DTPA) and ammonium citrate to extract the iron compounds. All of these solutions exhibit some level of iron removal; however the key is to find the most effective concentration at pH of around 7 of the reagent solution, to minimise the treatment time and find the most cost-effective treatment for the whole of the Mary Rose hull. Fe K-edge XAFS data from samples of Mary Rose timbers, before and after treatment by the chelating agents mentioned has been collected. The data collected provide valuable insights into the effectiveness of the treatment solutions.

  12. An Overview of the MaRIE X-FEL and Electron Radiography LINAC RF Systems

    SciTech Connect

    Bradley, Joseph Thomas III; Rees, Daniel Earl; Scheinker, Alexander; Sheffield, Richard L.

    2015-05-04

    The purpose of the Matter-Radiation Interactions in Extremes (MaRIE) facility at Los Alamos National Laboratory is to investigate the performance limits of materials in extreme environments. The MaRIE facility will utilize a 12 GeV linac to drive an X-ray Free-Electron Laser (FEL). Most of the same linac will also be used to perform electron radiography. The main linac is driven by two shorter linacs; one short linac optimized for X-FEL pulses and one for electron radiography. The RF systems have historically been the one of the largest single component costs of a linac. We will describe the details of the different types of RF systems required by each part of the linacs. Starting with the High Power RF system, we will present our methodology for the choice of RF system peak power and pulselength with respect to klystron parameters, modulator parameters, performance requirements and relative costs. We will also present an overview of the Low Level RF systems that are proposed for MaRIE and briefly describe their use with some proposed control schemes.

  13. The monster within: Mary Shelley's Frankenstein and a patient's fears of childbirth and mothering.

    PubMed

    Almond, B R

    1998-08-01

    This paper explores the fantasy, widespread among women, of giving birth to a monster, particularly a psychological monster. The author hypothesises two central intrapsychic issues underlying these fears: monsters are viewed as 'incest babies' or as reflections of maternal aggression--evil, destructive parts of the mother passed on to the infant. Shame about femaleness is postulated as a third factor in the fear of producing something monstrous. Mary Shelley's novel, 'Frankenstein', is an iconic literary representation of these themes. The author presents and discusses some psychobiographical material about Mary Shelley, speculating on her motives for writing this novel and tracing the intrapsychic concerns about incest and aggression as reflected in the novel itself. Some recent feminist and psychoanalytic critical readings of 'Frankenstein' are referenced as they reflect on the novel's concern with themes of female sexuality and procreation. Clinical material from the author's own practice is presented to illustrate these fears, so similar to those with which Mary Shelley was dealing. A discussion, citing some relevant literature, follows.

  14. What Mary Toft Felt: Women’s Voices, Pain, Power and the Body

    PubMed Central

    2015-01-01

    In autumn 1726, Mary Toft began to deliver rabbits in Godalming, Surrey. The case became a sensation and was reported widely in newspapers, popular pamphlets, poems and caricatures. Toft was attended by at least six different doctors, some members of the Royal College of Physicians or attached to the Royal Court, but no doctor declared the affair a hoax until Toft herself confessed on 7 December 1726. This article focuses on Toft’s three surviving confessions in order to explore not the doctors or even wider representations of the affair but instead the person of Mary Toft herself. These rare sources give rare insight into one woman’s experiences of reproduction in the early eighteenth century. The essay engages with recent work on recovering women’s voices in the past, reconstructing Mary Toft’s words and her embodied and affective experience of the affair. These documents suggest a revision to our understanding of the hoax of 1726, one that situates the affair not in the context of the scientific revolution and Enlightenment or the assumption of men’s control over midwifery, but instead in the context of power dynamics amongst women in the practices of early-modern reproduction and birth. PMID:27019607

  15. Long-term trends in the St. Marys River open water fish community

    USGS Publications Warehouse

    Schaeffer, Jeffrey S.; Fielder, David G.; Godby, Neal; Bowen, Anjanette; O'Connor, Lisa; Parrish, Josh; Greenwood, Susan; Chong, Stephen; Wright, Greg

    2011-01-01

    We examined trends in species composition and abundance of the St. Marys River fish community. Abundance data were available approximately once every six years from 1975 through 2006, and size and age data were available from 1995 through 2006. We also compared survey data in 2006 with results of a concurrent creel survey that year, as well as data from prior surveys spanning a 69 year time frame. The St. Marys River fish community was best characterized as a coolwater fish community with apparent little variation in species composition, and only slight variation in overall fish abundance since 1975. However, we did find recent trends in abundance among target species sought by anglers: centrarchids increased, percids appeared stable, and both northern pike Esox lucius and cisco Coregonus artedii declined. Survey results suggested that walleye (Sander vitreus) and yellow perch (Perca flavescens) experienced moderate exploitation but benefited from recent strong recruitment and faster growth. Mechanisms underlying declines of northern pike and cisco were not clear; reduced abundance could have resulted from high exploitation, variation in recruitment, or a combination of both factors. Despite these challenges, the St. Marys River fish community appears remarkably stable. We suggest that managers insure that creel surveys occur simultaneously with assessments, but periodic gill net surveys may no longer provide adequate data in support of recent, more complex management objectives. While additional surveys would add costs, more frequent data might ensure sustainability of a unique fish community that supports a large proportion of angler effort on Lake Huron.

  16. Solar Particle Events at Mars Seen by MARIE, 2002-2003

    NASA Technical Reports Server (NTRS)

    Cleghorn, T.; Zeitlin, C.; Cucinotta, F.; Saganti, P.; Anderson, V.; Lee, K. T.; Pinsky, L. S.; Turner, R.; Atwell, W.

    2004-01-01

    The MARIE detector aboard the 200 1 Mars Odyssey operated continuously between March 13, 2002, and October 28, 2003. During these twenty months, approximately 12 periods of enhanced solar particle activity were observed. The last of these, on October 26-28, 2003, caused the instrument to lose communication with the spacecraft. In addition to that very large event, several other major Solar Particle Events (SPEs) were observed. Those prior to March 2003 have been discussed elsewhere [I] and will be reviewed here. Many of the solar events seen at Mars correspond well to observations by GOES and ACE satellites near Earth. Some SPEs were observed by MARIE when Mars was on, or near, the opposite side of the sun as seen from Earth; and while a few of them - most notably the large full-halo Coronal Mass Ejections of July 2002 - coincided with events seen by the near-Earth satellites, others were not seen at Earth. Conversely, in this same time period, some SPEs were seen at Earth but not at Mars. Subsequent to February 2003, three SPEs were observed by MARIE, on March 18- 20, May 28 - June 3, and Oct. 26-28. Observations of solar energetic particles at Mars can be combined with data from other points in the heliosphere from, e.g., the Solar Heliospheric Observatory, ACE/CRIS, and GOES satellites near Earth, and Ulysses. Having several different observation points is useful for testing models of CME initiation and propagation.

  17. What Mary Toft Felt: Women's Voices, Pain, Power and the Body.

    PubMed

    Harvey, Karen

    2015-10-01

    In autumn 1726, Mary Toft began to deliver rabbits in Godalming, Surrey. The case became a sensation and was reported widely in newspapers, popular pamphlets, poems and caricatures. Toft was attended by at least six different doctors, some members of the Royal College of Physicians or attached to the Royal Court, but no doctor declared the affair a hoax until Toft herself confessed on 7 December 1726. This article focuses on Toft's three surviving confessions in order to explore not the doctors or even wider representations of the affair but instead the person of Mary Toft herself. These rare sources give rare insight into one woman's experiences of reproduction in the early eighteenth century. The essay engages with recent work on recovering women's voices in the past, reconstructing Mary Toft's words and her embodied and affective experience of the affair. These documents suggest a revision to our understanding of the hoax of 1726, one that situates the affair not in the context of the scientific revolution and Enlightenment or the assumption of men's control over midwifery, but instead in the context of power dynamics amongst women in the practices of early-modern reproduction and birth.

  18. Peroneal nerve branching suggests compression palsy in the deformities of Charcot-Marie Tooth disease.

    PubMed

    Guyton, Gregory P

    2006-10-01

    Altered expression of the PMP-22 protein may be implicated in Charcot-Marie-Tooth disease and the much rarer disease, hereditary liability to pressure palsy. An element of chronic pressure palsy may explain the unique distribution of motor imbalance in patients with Charcot-Marie-Tooth disease. If this is the case, innervation of the lateral leg motor units should show sufficient anatomic segregation to explain the variable disease patterns. Twelve fresh cadaver specimens were dissected to examine the innervation of the anterior and lateral compartment muscles from the peroneal nerve. Nine specimens had a branch to the peroneus longus at or proximal to nerve passage of the posterior fibular neck. The first branch to the peroneus longus was 2.1 +/- 6.7 mm proximal, and the first branch to the peroneus brevis was 110.9 +/- 19 mm distal. The nerve to the tibialis anterior originated within 5 mm of the reference point and wrapped transversely along the fibular neck for 17.2 +/- 1.4 mm. These discrete pathways to the individual motor units in the anterolateral leg were consistent with the possible implication of chronic pressure palsy in the patterns of atrophy in Charcot-Marie-Tooth disease.

  19. Mary Shelley's Frankenstein: exploring neuroscience, nature, and nurture in the novel and the films.

    PubMed

    Ginn, Sheryl R

    2013-01-01

    The story of Victor Frankenstein's quest to conquer death produced a legacy that has endured for almost 200 years. Powerful in its condemnation of the scientist's quest to achieve knowledge at any cost, Mary Shelley's Frankenstein is one of the most enduring novels of all time. It has never been out of print and has been translated to both stage and screen many times since its "birth." Numerous novels, short stories, and scripts have drawn upon Shelley's primary theme: the creation of a living organism from the dead, dying, and decaying body parts of human beings. Although Mary does not provide details of the animation process, particularly in her first edition, the process has been explored with a great deal of imagination and originality in the various cinematic portrayals of the story. Equally important as the theme of the scientist's quest for knowledge is the role that a creator plays in the life of its creation. Mary Shelley's novel pondered on how rejection would affect the offspring of such "unnatural" origins. In keeping with the "scientific" basis of the Creature's birth, cinematic portrayals attempted to provide a scientific rationale for the Creature's descent into madness and its evil behavior. From Robert Florey's initial script for the 1931 film directed by James Whale to the more recent films and television series, an abnormal brain is considered to be the cause of the madness and malignity of the Creature. © 2013 Elsevier B.V. All rights reserved.

  20. Shortened internodal length of dermal myelinated nerve fibres in Charcot–Marie-Tooth disease type 1A

    PubMed Central

    Saporta, Mario A.; Katona, Istvan; Lewis, Richard A.; Masse, Stacey; Shy, Michael E.

    2009-01-01

    Charcot–Marie-Tooth disease type 1A is the most common inherited neuropathy and is caused by duplication of chromosome 17p11.2 containing the peripheral myelin protein-22 gene. This disease is characterized by uniform slowing of conduction velocities and secondary axonal loss, which are in contrast with non-uniform slowing of conduction velocities in acquired demyelinating disorders, such as chronic inflammatory demyelinating polyradiculoneuropathy. Mechanisms responsible for the slowed conduction velocities and axonal loss in Charcot–Marie-Tooth disease type 1A are poorly understood, in part because of the difficulty in obtaining nerve samples from patients, due to the invasive nature of nerve biopsies. We have utilized glabrous skin biopsies, a minimally invasive procedure, to evaluate these issues systematically in patients with Charcot–Marie-Tooth disease type 1A (n = 32), chronic inflammatory demyelinating polyradiculoneuropathy (n = 4) and healthy controls (n = 12). Morphology and molecular architecture of dermal myelinated nerve fibres were examined using immunohistochemistry and electron microscopy. Internodal length was uniformly shortened in patients with Charcot–Marie-Tooth disease type 1A, compared with those in normal controls (P < 0.0001). Segmental demyelination was absent in the Charcot–Marie-Tooth disease type 1A group, but identifiable in all patients with chronic inflammatory demyelinating polyradiculoneuropathy. Axonal loss was measurable using the density of Meissner corpuscles and associated with an accumulation of intra-axonal mitochondria. Our study demonstrates that skin biopsy can reveal pathological and molecular architectural changes that distinguish inherited from acquired demyelinating neuropathies. Uniformly shortened internodal length in Charcot–Marie-Tooth disease type 1A suggests a potential developmental defect of internodal lengthening. Intra-axonal accumulation of mitochondria provides new insights into the