Development of CDMS-II Surface Event Rejection Techniques and Their Extensions to Lower Energy Thresholds

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hofer, Thomas James

2014-12-01

The CDMS-II phase of the Cryogenic Dark Matter Search, a dark matter direct-detection experiment, was operated at the Soudan Underground Laboratory from 2003 to 2008. The full payload consisted of 30 ZIP detectors, totaling approximately 1.1 kg of Si and 4.8 kg of Ge, operated at temperatures of 50 mK. The ZIP detectors read out both ionization and phonon pulses from scatters within the crystals; channel segmentation and analysis of pulse timing parameters allowed e ective ducialization of the crystal volumes and background rejection su cient to set world-leading limits at the times of their publications. A full re-analysis ofmore » the CDMS-II data was motivated by an improvement in the event reconstruction algorithms which improved the resolution of ionization energy and timing information. The Ge data were re-analyzed using three distinct background-rejection techniques; the Si data from runs 125 - 128 were analyzed for the rst time using the most successful of the techniques from the Ge re-analysis. The results of these analyses prompted a novel \\mid-threshold" analysis, wherein energy thresholds were lowered but background rejection using phonon timing information was still maintained. This technique proved to have signi cant discrimination power, maintaining adequate signal acceptance and minimizing background leakage. The primary background for CDMS-II analyses comes from surface events, whose poor ionization collection make them di cult to distinguish from true nuclear recoil events. The novel detector technology of SuperCDMS, the successor to CDMS-II, uses interleaved electrodes to achieve full ionization collection for events occurring at the top and bottom detector surfaces. This, along with dual-sided ionization and phonon instrumentation, allows for excellent ducialization and relegates the surface-event rejection techniques of CDMS-II to a secondary level of background discrimination. Current and future SuperCDMS results hold great promise for mid- to low-mass WIMP-search results.« less

General purpose simulation system of the data management system for Space Shuttle mission 18

NASA Technical Reports Server (NTRS)

Bengtson, N. M.; Mellichamp, J. M.; Smith, O. C.

1976-01-01

A simulation program for the flow of data through the Data Management System of Spacelab and Space Shuttle was presented. The science, engineering, command and guidance, navigation and control data were included. The programming language used was General Purpose Simulation System V (OS). The science and engineering data flow was modeled from its origin at the experiments and subsystems to transmission from Space Shuttle. Command data flow was modeled from the point of reception onboard and from the CDMS Control Panel to the experiments and subsystems. The GN&C data flow model handled data between the General Purpose Computer and the experiments and subsystems. Mission 18 was the particular flight chosen for simulation. The general structure of the program is presented, followed by a user's manual. Input data required to make runs are discussed followed by identification of the output statistics. The appendices contain a detailed model configuration, program listing and results.

Data Management as a Cluster Middleware Centerpiece

NASA Technical Reports Server (NTRS)

Zero, Jose; McNab, David; Sawyer, William; Cheung, Samson; Duffy, Daniel; Rood, Richard; Webster, Phil; Palm, Nancy; Salmon, Ellen; Schardt, Tom

2004-01-01

Through earth and space modeling and the ongoing launches of satellites to gather data, NASA has become one of the largest producers of data in the world. These large data sets necessitated the creation of a Data Management System (DMS) to assist both the users and the administrators of the data. Halcyon Systems Inc. was contracted by the NASA Center for Computational Sciences (NCCS) to produce a Data Management System. The prototype of the DMS was produced by Halcyon Systems Inc. (Halcyon) for the Global Modeling and Assimilation Office (GMAO). The system, which was implemented and deployed within a relatively short period of time, has proven to be highly reliable and deployable. Following the prototype deployment, Halcyon was contacted by the NCCS to produce a production DMS version for their user community. The system is composed of several existing open source or government-sponsored components such as the San Diego Supercomputer Center s (SDSC) Storage Resource Broker (SRB), the Distributed Oceanographic Data System (DODS), and other components. Since Data Management is one of the foremost problems in cluster computing, the final package not only extends its capabilities as a Data Management System, but also to a cluster management system. This Cluster/Data Management System (CDMS) can be envisioned as the integration of existing packages.

An engineering approach to design of dextran microgels size fabricated by water/oil emulsification.

PubMed

Salimi-Kenari, Hamed; Imani, Mohammad; Nodehi, Azizollah; Abedini, Hossein

2016-09-01

A correlation, based on fluid mechanics, has been investigated for the mean particle diameter of crosslinked dextran microgels (CDMs) prepared via a water/oil emulsification methodology conducted in a single-stirred vessel. To this end, non-dimensional correlations were developed to predict the mean particle size of CDMs as a function of Weber number, Reynolds number and viscosity number similar to ones introduced for liquid-liquid dispersions. Moreover, a Rosin-Rammler distribution function has been successfully applied to the microgel particle size distributions. The correlations were validated using experimentally obtained mean particle sizes for CDMs prepared at different stirring conditions. The validated correlation is especially applicable to medical and pharmaceutical applications where strict control on the mean particle size and size distribution of CDMs are extremely essential. [Formula: see text].

Healthcare managers' construction of the manager role in relation to the medical profession.

PubMed

von Knorring, Mia; Alexanderson, Kristina; Eliasson, Miriam A

2016-05-16

Purpose - The purpose of this paper is to explore how healthcare managers construct the manager role in relation to the medical profession in their organisations. Design/methodology/approach - In total, 18 of Sweden's 20 healthcare chief executive officers (CEOs) and 20 clinical department managers (CDMs) were interviewed about their views on management of physicians. Interviews were performed in the context of one aspect of healthcare management; i.e., management of physicians' sickness certification practice. A discourse analysis approach was used for data analysis. Findings - Few managers used a management-based discourse to construct the manager role. Instead, a profession-based discourse dominated and managers frequently used the attributes "physician" or "non-physician" to categorise themselves or other managers in their managerial roles. Some managers, both CEOs and CDMs, shifted between the management- and profession-based discourses, resulting in a kind of "yes, but […]" approach to management in the organisations. The dominating profession-based discourse served to reproduce the power and status of physicians within the organisation, thereby rendering the manager role weaker than the medical profession for both physician and non-physician managers. Research limitations/implications - Further studies are needed to explore the impact of gender, managerial level, and basic profession on how managers construct the manager role in relation to physicians. Practical implications - The results suggest that there is a need to address the organisational conditions for managers' role taking in healthcare organisations. Originality/value - Despite the general strengthening of the manager position in healthcare through political reforms during the last decades, this study shows that a profession-based discourse clearly dominated in how the managers constructed the manager role in relation to the medical profession on the workplace level in their organisations.

Advancing the Search for Dark Matter: from CDMS II to SuperCDMS

NASA Astrophysics Data System (ADS)

Hertel, Scott A.

An overwhelming proportion of the universe (83% by mass) is composed of particles we know next to nothing about. Detecting these dark matter particles directly, through hypothesized weak-force-mediated recoils with nuclear targets here on earth, could shed light on what these particles are, how they relate to the standard model, and how the standard model fits within a more fundamental understanding. This thesis describes two such experimental efforts: CDMS II (2007-2009) and SuperCDMS Soudan (ongoing). The general abilities and sensitivities of both experiments are laid out, placing a special emphasis on the detector technology, and how this technology has evolved from the first to the second experiment. Some topics on which I spent significant efforts are described here only in overview (in particular the details of the CDMS II analysis, which has been laid out many times before), and some topics which are not described elsewhere are given a somewhat deeper treatment. In particular, this thesis is hopefully a good reference for those interested in the annual modulation limits placed on the low-energy portion of the CDMS II exposure, the design of the detectors for SuperCDMS Soudan, and an overview of the extremely informative data these detectors produce. It is an exciting time. The technology I've had the honor to work on the past few years provides a wealth of information about each event, more so than any other direct detection experiment, and we are still learning how to optimally use all this information. Initial tests from the surface and now underground suggest this technology has the background rejection abilities necessary for a planned 200kg experiment or even ton-scale experiment, putting us on the threshold of probing parameter space orders of magnitude from where the field currently stands. (Copies available exclusively from MIT Libraries, libraries.mit.edu/docs - docs@mit.edu)

Advancing the Search for Dark Matter: from CDMS II to SuperCDMS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hertel, Scott A.

2012-09-01

An overwhelming proportion of the universe (83% by mass) is composed of particles we know next to nothing about. Detecting these dark matter particles directly, through hypothesized weak-force-mediated recoils with nuclear targets here on earth, could shed light on what these particles are, how they relate to the standard model, and how the standard model ts within a more fundamental understanding. This thesis describes two such experimental eorts: CDMS II (2007-2009) and SuperCDMS Soudan (ongoing). The general abilities and sensitivities of both experiments are laid out, placing a special emphasis on the detector technology, and how this technology has evolvedmore » from the rst to the second experiment. Some topics on which I spent signicant eorts are described here only in overview (in particular the details of the CDMS II analysis, which has been laid out many times before), and some topics which are not described elsewhere are given a somewhat deeper treatment. In particular, this thesis is hopefully a good reference for those interested in the annual modulation limits placed on the low-energy portion of the CDMS II exposure, the design of the detectors for SuperCDMS Soudan, and an overview of the extremely informative data these detectors produce. It is an exciting time. The technology I've had the honor to work on the past few years provides a wealth of information about each event, more so than any other direct detection experiment, and we are still learning how to optimally use all this information. Initial tests from the surface and now underground suggest this technology has the background rejection abilities necessary for a planned 200kg experiment or even ton-scale experiment, putting us on the threshold of probing parameter space orders of magnitude from where the eld currently stands.« less

Comparison among cognitive diagnostic models for the TIMSS 2007 fourth grade mathematics assessment.

PubMed

Yamaguchi, Kazuhiro; Okada, Kensuke

2018-01-01

A variety of cognitive diagnostic models (CDMs) have been developed in recent years to help with the diagnostic assessment and evaluation of students. Each model makes different assumptions about the relationship between students' achievement and skills, which makes it important to empirically investigate which CDMs better fit the actual data. In this study, we examined this question by comparatively fitting representative CDMs to the Trends in International Mathematics and Science Study (TIMSS) 2007 assessment data across seven countries. The following two major findings emerged. First, in accordance with former studies, CDMs had a better fit than did the item response theory models. Second, main effects models generally had a better fit than other parsimonious or the saturated models. Related to the second finding, the fit of the traditional parsimonious models such as the DINA and DINO models were not optimal. The empirical educational implications of these findings are discussed.

Comparison among cognitive diagnostic models for the TIMSS 2007 fourth grade mathematics assessment

PubMed Central

Okada, Kensuke

2018-01-01

A variety of cognitive diagnostic models (CDMs) have been developed in recent years to help with the diagnostic assessment and evaluation of students. Each model makes different assumptions about the relationship between students’ achievement and skills, which makes it important to empirically investigate which CDMs better fit the actual data. In this study, we examined this question by comparatively fitting representative CDMs to the Trends in International Mathematics and Science Study (TIMSS) 2007 assessment data across seven countries. The following two major findings emerged. First, in accordance with former studies, CDMs had a better fit than did the item response theory models. Second, main effects models generally had a better fit than other parsimonious or the saturated models. Related to the second finding, the fit of the traditional parsimonious models such as the DINA and DINO models were not optimal. The empirical educational implications of these findings are discussed. PMID:29394257

Economic evaluation of Avonex (interferon beta-Ia) in patients following a single demyelinating event.

PubMed

Iskedjian, Michael; Walker, John H; Gray, Trevor; Vicente, Colin; Einarson, Thomas R; Gehshan, Adel

2005-10-01

Interferon beta-Ia (Avonex) 30 microg, intramuscular (i.m.), once weekly is efficacious in delaying clinically definite multiple sclerosis (CDMS) following a single demyelinating event (SDE). This study determined the cost effectiveness of Avonex compared to current treatment in delaying the onset of CDMS. A cost-effectiveness analysis (CEA) and cost-utility analysis (CUA) were performed from Ministry of Health (MoH) and societal perspectives. For CEA, the outcome of interest was time spent in the pre-CDMS state, termed monosymptomatic life years (MLY) gained. For CUA, the outcome was quality-adjusted monosymptomatic life years (QAMLY) gained. A Markov model was developed with transitional probabilities and utilities derived from the literature. Costs were reported in 2002 Canadian dollars. Costs and outcomes were discounted at 5%. The time horizon was 12 years for the CEA, and 15 years for the CUA. All uncertainties were tested via univariate and multivariate sensitivity analyses. In the CEA, the incremental cost of Avonex per ILYgained was $53110 and $44789 from MoH and societal perspectives, respectively. In the CUA, the incremental cost of Avonex per QAMLY gained was $227586 and $189286 from MoH and societal perspectives, respectively. Both models were sensitive to the probability of progressing to CDMS and the analytical time horizon. The CUA was sensitive to the utilities value. Avonex may be considered as a reasonably cost-effective approach to treatment of patients experiencing an SDE In addition, the overall incremental cost-effectiveness profile of Avonex improves if treatment is initiated in pre-CDMS rather than waiting until CDMS.

The SuperCDMS SNOLAB Detector Tower

NASA Astrophysics Data System (ADS)

Aramaki, Tsuguo

2016-08-01

The SuperCDMS collaboration is moving forward with the design and construction of SuperCDMS SNOLAB, where the initial deployment will include ˜ 30 kg of Ge and ˜ 5 kg of Si detectors. Here, we will discuss the associated cryogenic cold hardware required for the detector readout. The phonon signals will be read out with superconducting quantum interference device arrays and the ionization signals will use high electron mobility transistor amplifiers operating at 4 K. A number of design challenges exist regarding the required wiring complex impedance, noise pickup, vibration, and thermal isolation. Our progress to date will be presented.

Nuclear-Recoil Energy Scale in CDMS II Silicon Dark-Matter Detectors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Agnese, R.; et al.

The Cryogenic Dark Matter Search (CDMS II) experiment aims to detect dark matter particles that elastically scatter from nuclei in semiconductor detectors. The resulting nuclear-recoil energy depositions are detected by ionization and phonon sensors. Neutrons produce a similar spectrum of low-energy nuclear recoils in such detectors, while most other backgrounds produce electron recoils. The absolute energy scale for nuclear recoils is necessary to interpret results correctly. The energy scale can be determined in CDMS II silicon detectors using neutrons incident from a broad-spectrummore » $$^{252}$$Cf source, taking advantage of a prominent resonance in the neutron elastic scattering cross section of silicon at a recoil (neutron) energy near 20 (182) keV. Results indicate that the phonon collection efficiency for nuclear recoils is $$4.8^{+0.7}_{-0.9}$$% lower than for electron recoils of the same energy. Comparisons of the ionization signals for nuclear recoils to those measured previously by other groups at higher electric fields indicate that the ionization collection efficiency for CDMS II silicon detectors operated at $$\\sim$$4 V/cm is consistent with 100% for nuclear recoils below 20 keV and gradually decreases for larger energies to $$\\sim$$75% at 100 keV. The impact of these measurements on previously published CDMS II silicon results is small.« less

Detector Simulation and WIMP Search Analysis for the Cryogenic Dark Matter Search Experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

McCarthy, Kevin

2013-06-01

Astrophysical and cosmological measurements on the scales of galaxies, galaxy clusters, and the universe indicate that 85% of the matter in the universe is composed of dark matter, made up of non-baryonic particles that interact with cross-sections on the weak scale or lower. Hypothetical Weakly Interacting Massive Particles, or WIMPs, represent a potential solution to the dark matter problem, and naturally arise in certain Standard Model extensions. The Cryogenic Dark Matter Search (CDMS) collaboration aims to detect the scattering of WIMP particles from nuclei in terrestrial detectors. Germanium and silicon particle detectors are deployed in the Soudan Underground Laboratory inmore » Minnesota. These detectors are instrumented with phonon and ionization sensors, which allows for discrimination against electromagnetic backgrounds, which strike the detector at rates orders of magnitude higher than the expected WIMP signal. This dissertation presents the development of numerical models of the physics of the CDMS detectors, implemented in a computational package collectively known as the CDMS Detector Monte Carlo (DMC). After substantial validation of the models against data, the DMC is used to investigate potential backgrounds to the next iteration of the CDMS experiment, known as SuperCDMS. Finally, an investigation of using the DMC in a reverse Monte Carlo analysis of WIMP search data is presented.« less

The cryogenics design of the SuperCDMS SNOLAB experiment

NASA Astrophysics Data System (ADS)

Hollister, M. I.; Bauer, D. A.; Dhuley, R. C.; Lukens, P.; Martin, L. D.; Ruschman, M. K.; Schmitt, R. L.; Tatkowski, G. L.

2017-12-01

The Super Cryogenic Dark Matter Search (SuperCDMS) experiment is a direct detection dark matter experiment intended for deployment to the SNOLAB underground facility in Ontario, Canada. With a payload of up to 186 germanium and silicon crystal detectors operating below 15 mK, the cryogenic architecture of the experiment is complex. Further, the requirement that the cryostat presents a low radioactive background to the detectors limits the materials and techniques available for construction, and heavily influences the design of the cryogenics system. The resulting thermal architecture is a closed cycle (no liquid cryogen) system, with stages at 50 and 4 K cooled with gas and fluid circulation systems and stages at 1 K, 250 mK and 15 mK cooled by the lower temperature stages of a large, cryogen-free dilution refrigerator. This paper describes the thermal design of the experiment, including details of the cooling systems, mechanical designs and expected performance of the system under operational conditions.

Phonon Sensor Dynamics for Cryogenic Dark Matter Search Experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yen, Jeffrey

Understanding the quasiparticle diffusion process inside sputtered aluminum (Al thin films (~ 0.1-1 μm is critical for the Cryogenic Dark Matter Search (CDMS experiment to further optimize its detectors to directly search for dark matter. An initial study with Al films was undertaken by our group ~ 20 years ago, but some important questions were not answered at the time. This thesis can be considered a continuation of that critical study. The CDMS experiment utilizes high purity silicon and germanium crystals to simultaneously measure ionization and phonons created by particle interactions. In addition to describing some of the rich physicsmore » involved in simultaneously detecting ionization and phonons with a CDMS detector, this thesis focuses on the detailed physics of the phonon sensors themselves, which are patterned onto CDMS detector surfaces. CDMS detectors use thin sputtered Al films to collect phonon energy when it propagates to the surfaces of the detector crystals. The phonon energy breaks Cooper pairs and creates quasiparticles (qps). These qps diffuse until they get trapped in an proximitized “overlap” region where lower-Tc tungsten films connect to the Al film. These tungsten films are the transition edge sensors (W-TESs CDMS uses to readout phonon signals. We performed a wide range of experiments using several sets of test devices designed and fabricated specifically for this work. The devices were used mostly to study quasiparticle (qp transport in Al films and qp transmission through Al/W interfaces. The results of this work are being used to optimize the design of detectors for SuperCDMS SNOLAB. This thesis is intended for CDMS collaborators who are interested in knowing more about the detailed fundamentals of how our phonon sensors work so they can take full advantage of their benefits. However, this work can also be read by general readers who are interested in particle detection using TES technology. This thesis contains eight chapters. The first chapter gives basic background information about dark matter and searches for it. We then describe the basic CDMS detector technology in Chapter two. Chapter three focuses on superconductivity and explains some of the solid state physic most relevant to our Al and W film studies. We then turn our attention to the fabrication processes used to make test devices, and describe some of the studies done to characterize our W and Al film properties. Chapter five explains the experimental setup including how a 3He/4He dilution refrigerator works, and how our electronics were configured. We then get to chapter six where we present key experimental results. Chapter seven covers the TES model we used for our test devices to simulate the data pulse shapes and reconstruct the pulse energies. We also describe the diffusion models used to fit our data. Finally, we end with a short summary of our findings and provide a few suggestions for future studies.« less

Cognitive Diagnostic Models for Tests with Multiple-Choice and Constructed-Response Items

ERIC Educational Resources Information Center

Kuo, Bor-Chen; Chen, Chun-Hua; Yang, Chih-Wei; Mok, Magdalena Mo Ching

2016-01-01

Traditionally, teachers evaluate students' abilities via their total test scores. Recently, cognitive diagnostic models (CDMs) have begun to provide information about the presence or absence of students' skills or misconceptions. Nevertheless, CDMs are typically applied to tests with multiple-choice (MC) items, which provide less diagnostic…

On the Estimation of Standard Errors in Cognitive Diagnosis Models

ERIC Educational Resources Information Center

Philipp, Michel; Strobl, Carolin; de la Torre, Jimmy; Zeileis, Achim

2018-01-01

Cognitive diagnosis models (CDMs) are an increasingly popular method to assess mastery or nonmastery of a set of fine-grained abilities in educational or psychological assessments. Several inference techniques are available to quantify the uncertainty of model parameter estimates, to compare different versions of CDMs, or to check model…

A General Cognitive Diagnosis Model for Continuous-Response Data

ERIC Educational Resources Information Center

Minchen, Nathan; de la Torre, Jimmy

2018-01-01

Cognitive diagnosis models (CDMs) allow for the extraction of fine-grained, multidimensional diagnostic information from appropriately designed tests. In recent years, interest in such models has grown as formative assessment grows in popularity. Many dichotomous as well as several polytomous CDMs have been proposed in the last two decades, but…

Cognitive Diagnostic Modeling Using R

ERIC Educational Resources Information Center

Ravand, Hamdollah

2015-01-01

Cognitive diagnostic models (CDM) have been around for more than a decade but their application is far from widespread for mainly two reasons: (1) CDMs are novel, as compared to traditional IRT models. Consequently, many researchers lack familiarity with them and their properties, and (2) Software programs doing CDMs have been expensive and not…

Radon Mitigation for the SuperCDMS-SNOLAB Dark Matter Experiment

NASA Astrophysics Data System (ADS)

Street, Joseph; SuperCDMS Collaboration

2016-03-01

Experiments that seek to detect very rare processes, such as interactions of the dark matter particles thought to make up 85% of the mass of the universe, may suffer background interactions from radon daughters that have plated out onto detector surfaces. To reduce these backgrounds, an ultra-low-radon cleanroom was built at the South Dakota School of Mines & Technology. Cleanroom air is supplied by an optimized vacuum-swing-adsorption radon mitigation system that has achieved a > 300 × reduction from an input activity of 58.6 +/- 0.7 Bq/m3 to a cleanroom activity of 0.13 +/- 0.06 Bq/m3. Expected backgrounds due to radon daughters for the SuperCDMS dark matter search will be presented.

Prototyping an active neutron veto for SuperCDMS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Calkins, Robert; Loer, Ben

2015-08-17

Neutrons, originating cosmogenically or from radioactive decays, can produce signals in dark matter detectors that are indistinguishable from Weakly Interacting Massive Particles (WIMPs). To combat this background for the SuperCDMS SNOLAB experiment, we are investigating designs for an active neutron veto within the constrained space of the compact SuperCDMS passive shielding. The current design employs an organic liquid scintillator mixed with an agent to enhance thermal neutron captures, with the scintillation light collected using wavelength-shifting fibers and read out by silicon photo-multipliers. We will describe the proposed veto and its predicted efficiency in detail and give some recent results frommore » our R&D and prototyping efforts.« less

Prototyping an Active Neutron Veto for SuperCDMS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Calkins, Robert; Loer, Ben

2015-08-17

Neutrons, originating cosmogenically or from radioactive decays, can produce signals in dark matter detectors that are indistinguishable from Weakly Interacting Massive Particles (WIMPs). To combat this background for the SuperCDMS SNOLAB experiment, we are investigating designs for an active neutron veto within the constrained space of the compact SuperCDMS passive shielding. The current design employs an organic liquid scintillator mixed with an agent to enhance thermal neutron captures, with the scintillation light collected using wavelength-shifting fibers and read out by silicon photo-multipliers. We will describe the proposed veto and its predicted efficiency in detail and give some recent results frommore » our R&D and prototyping efforts.« less

A Binary Programming Approach to Automated Test Assembly for Cognitive Diagnosis Models

ERIC Educational Resources Information Center

Finkelman, Matthew D.; Kim, Wonsuk; Roussos, Louis; Verschoor, Angela

2010-01-01

Automated test assembly (ATA) has been an area of prolific psychometric research. Although ATA methodology is well developed for unidimensional models, its application alongside cognitive diagnosis models (CDMs) is a burgeoning topic. Two suggested procedures for combining ATA and CDMs are to maximize the cognitive diagnostic index and to use a…

Multilevel Cognitive Diagnosis Models for Assessing Changes in Latent Attributes

ERIC Educational Resources Information Center

Huang, Hung-Yu

2017-01-01

Cognitive diagnosis models (CDMs) have been developed to evaluate the mastery status of individuals with respect to a set of defined attributes or skills that are measured through testing. When individuals are repeatedly administered a cognitive diagnosis test, a new class of multilevel CDMs is required to assess the changes in their attributes…

Evaluation of Model Fit in Cognitive Diagnosis Models

ERIC Educational Resources Information Center

Hu, Jinxiang; Miller, M. David; Huggins-Manley, Anne Corinne; Chen, Yi-Hsin

2016-01-01

Cognitive diagnosis models (CDMs) estimate student ability profiles using latent attributes. Model fit to the data needs to be ascertained in order to determine whether inferences from CDMs are valid. This study investigated the usefulness of some popular model fit statistics to detect CDM fit including relative fit indices (AIC, BIC, and CAIC),…

Measurement of Nuclear Recoils in the CDMS II Dark Matter Search

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fallows, Scott Mathew

The Cryogenic Dark Matter Search (CDMS) experiment is designed to directly detect elastic scatters of weakly-interacting massive dark matter particles (WIMPs), on target nuclei in semiconductor crystals composed of Si and Ge. These scatters would occur very rarely, in an overwhelming background composed primarily of electron recoils from photons and electrons, as well as a smaller but non-negligible background of WIMP-like nuclear recoils from neutrons. The CDMS II generation of detectors simultaneously measure ionization and athermal phonon signals from each scatter, allowing discrimination against virtually all electron recoils in the detector bulk. Pulse-shape timing analysis allows discrimination against nearly allmore » remaining electron recoils taking place near detector surfaces. Along with carefully limited neutron backgrounds, this experimental program allowed for \\background- free" operation of CDMS II at Soudan, with less than one background event expected in each WIMP-search analysis. As a result, exclusionary upper-limits on WIMP-nucleon interaction cross section were placed over a wide range of candidate WIMP masses, ruling out large new regions of parameter space.« less

SuperCDMS Underground Detector Fabrication Facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Platt, M.; Mahapatra, R.; Bunker, Raymond A.

The SuperCDMS SNOLAB dark matter experiment processes Ge and Si crystals into fully tested phonon and ionization detectors at surface fabrication and test facilities. If not mitigated, it is anticipated that trace-level production of radioisotopes in the crystals due to exposure to cosmic rays at (or above) sea level will result in the dominant source of background events in future dark matter searches using the current SuperCDMS detector technology. Fabrication and testing of detectors in underground facilities shielded from cosmic radiation is one way to directly reduce production of trace levels of radioisotopes, thereby improving experimental sensitivity for the discoverymore » of dark matter beyond the level of the current experiment. In this report, we investigate the cost and feasibility to establish a complete detector fabrication processing chain in an underground location to mitigate cosmogenic activation of the Ge and Si detector substrates. For a specific and concrete evaluation, we explore options for such a facility located at SNOLAB, an underground laboratory in Sudbury, Canada hosting the current and future experimental phases of SuperCDMS.« less

The Cologne Database for Molecular Spectroscopy, CDMS, in the Virtual Atomic and Molecular Data Centre, VAMDC

NASA Astrophysics Data System (ADS)

Endres, Christian P.; Schlemmer, Stephan; Schilke, Peter; Stutzki, Jürgen; Müller, Holger S. P.

2016-09-01

The Cologne Database for Molecular Spectroscopy, CDMS, was founded 1998 to provide in its catalog section line lists of mostly molecular species which are or may be observed in various astronomical sources (usually) by radio astronomical means. The line lists contain transition frequencies with qualified accuracies, intensities, quantum numbers, as well as further auxiliary information. They have been generated from critically evaluated experimental line lists, mostly from laboratory experiments, employing established Hamiltonian models. Separate entries exist for different isotopic species and usually also for different vibrational states. As of December 2015, the number of entries is 792. They are available online as ascii tables with additional files documenting information on the entries. The Virtual Atomic and Molecular Data Centre, VAMDC, was founded more than 5 years ago as a common platform for atomic and molecular data. This platform facilitates exchange not only between spectroscopic databases related to astrophysics or astrochemistry, but also with collisional and kinetic databases. A dedicated infrastructure was developed to provide a common data format in the various databases enabling queries to a large variety of databases on atomic and molecular data at once. For CDMS, the incorporation in VAMDC was combined with several modifications on the generation of CDMS catalog entries. Here we introduce related changes to the data structure and the data content in the CDMS. The new data scheme allows us to incorporate all previous data entries but in addition allows us also to include entries based on new theoretical descriptions. Moreover, the CDMS entries have been transferred into a mySQL database format. These developments within the VAMDC framework have in part been driven by the needs of the astronomical community to be able to deal efficiently with large data sets obtained with the Herschel Space Telescope or, more recently, with the Atacama Large Millimeter Array.

Automated Test Assembly for Cognitive Diagnosis Models Using a Genetic Algorithm

ERIC Educational Resources Information Center

Finkelman, Matthew; Kim, Wonsuk; Roussos, Louis A.

2009-01-01

Much recent psychometric literature has focused on cognitive diagnosis models (CDMs), a promising class of instruments used to measure the strengths and weaknesses of examinees. This article introduces a genetic algorithm to perform automated test assembly alongside CDMs. The algorithm is flexible in that it can be applied whether the goal is to…

Impact of Diagnosticity on the Adequacy of Models for Cognitive Diagnosis under a Linear Attribute Structure: A Simulation Study

ERIC Educational Resources Information Center

de La Torre, Jimmy; Karelitz, Tzur M.

2009-01-01

Compared to unidimensional item response models (IRMs), cognitive diagnostic models (CDMs) based on latent classes represent examinees' knowledge and item requirements using discrete structures. This study systematically examines the viability of retrofitting CDMs to IRM-based data with a linear attribute structure. The study utilizes a procedure…

Assessment of Differential Item Functioning under Cognitive Diagnosis Models: The DINA Model Example

ERIC Educational Resources Information Center

Li, Xiaomin; Wang, Wen-Chung

2015-01-01

The assessment of differential item functioning (DIF) is routinely conducted to ensure test fairness and validity. Although many DIF assessment methods have been developed in the context of classical test theory and item response theory, they are not applicable for cognitive diagnosis models (CDMs), as the underlying latent attributes of CDMs are…

Nonlinear Penalized Estimation of True Q-Matrix in Cognitive Diagnostic Models

ERIC Educational Resources Information Center

Xiang, Rui

2013-01-01

A key issue of cognitive diagnostic models (CDMs) is the correct identification of Q-matrix which indicates the relationship between attributes and test items. Previous CDMs typically assumed a known Q-matrix provided by domain experts such as those who developed the questions. However, misspecifications of Q-matrix had been discovered in the past…

Detection of Q-Matrix Misspecification Using Two Criteria for Validation of Cognitive Structures under the Least Squares Distance Model

ERIC Educational Resources Information Center

Romero, Sonia J.; Ordoñez, Xavier G.; Ponsoda, Vincente; Revuelta, Javier

2014-01-01

Cognitive Diagnostic Models (CDMs) aim to provide information about the degree to which individuals have mastered specific attributes that underlie the success of these individuals on test items. The Q-matrix is a key element in the application of CDMs, because contains links item-attributes representing the cognitive structure proposed for solve…

Evidence of Clostridium perfringens epsilon toxin associated with multiple sclerosis.

PubMed

Wagley, Sariqa; Bokori-Brown, Monika; Morcrette, Helen; Malaspina, Andrea; D'Arcy, Caroline; Gnanapavan, Sharmilee; Lewis, Nicholas; Popoff, Michel R; Raciborska, Dominika; Nicholas, Richard; Turner, Ben; Titball, Richard W

2018-04-01

It was recently reported that, using Western blotting, some multiple sclerosis (MS) patients in the United States had antibodies against epsilon toxin (Etx) from Clostridium perfringens, suggesting that the toxin may play a role in the disease. We investigated for serum antibodies against Etx in UK patients with clinically definite multiple sclerosis (CDMS) or presenting with clinically isolated syndrome (CIS) or optic neuritis (ON) and in age- and gender-matched controls. We tested sera from CDMS, CIS or ON patients or controls by Western blotting. We also tested CDMS sera for reactivity with linear overlapping peptides spanning the amino acid sequence (Pepscan) of Etx. Using Western blotting, 24% of sera in the combined CDMS, CIS and ON groups ( n = 125) reacted with Etx. In the control group ( n = 125), 10% of the samples reacted. Using Pepscan, 33% of sera tested reacted with at least one peptide, whereas in the control group only 16% of sera reacted. Out of 61 samples, 21 (43%) were positive to one or other testing methodology. Three samples were positive by Western blotting and Pepscan. Our results broadly support the previous findings and the role of Etx in the aetiology of MS warrants further investigation.

A modified detector concept for SuperCDMS: The HiZIP and its charge performance

NASA Astrophysics Data System (ADS)

Page, Kedar Mohan

SuperCDMS is a leading direct dark matter search experiment which uses solid state detectors (Ge crystals) at milliKelvin temperatures to look for nuclear recoils caused by dark matter interactions in the detector. 'Weakly Interacting Massive Particles' (WIMPs) are the most favoured dark matter candidate particles. SuperCDMS, like many other direct dark matter search experiments, primarily looks for WIMPs. The measurement of both the ionization and the lattice vibration (phonon) signals from an interaction in the detector allow it to discriminate against electron recoils which are the main source of background for WIMP detection. SuperCDMS currently operates about 9 kgs worth of germanium detectors at the Soudan underground lab in northern Minnesota. In its next phase, SuperCDMS SNOLAB, it plans to use 100-200 kg of target mass (Ge) which would allow it to probe more of the interesting and unexplored parameter space for WIMPs predicted by theoretical models. The SuperCDMS Queen's Test Facility is a detector testing facility which is intended to serve detector testing and detector research and development purposes for the SuperCDMS experiment. A modified detector called the 'HiZIP' (Half-iZIP), which is reduced in complexity in comparison to the currently used iZIP (interleaved Z-sensitive Ionization and Phonon mediated) detectors, is studied in this thesis. The HiZIP detector design also serves to discriminate against background from multiple scatter events occurring close to the surfaces in a single detector. Studies carried out to compare the surface event leakage in the HiZIP detector using limited information from iZIP data taken at SuperCDMS test facility at UC Berkley produce a highly conservative upper limit of 5 out of 10,000 events at 90% confidence level. This upper limit is the best among many different HiZIP configurations that were investigated and is comparable to the upper limit calculated for an iZIP detector in the same way using the same data. A real HiZIP device operated at Queen's Test Facility produced an exposure limited 90% upper limit of about 1 in 100 events for surface event leakage. The data used in these studies contain true nuclear recoil events from cosmogenic and ambient neutrons. This background was not subtracted in the calculation of the upper limits stated above and hence they are highly conservative. A surface event source was produced by depositing lead-210 from radon exposure onto a copper plate. This source was then used to take data for a surface event discrimination study of the HiZIP detector operated at Queen's Test Facility. A study of the contribution of the noise from capacitive crosstalk between charge sensors in a HiZIP detector configuration was investigated, confirming the expectation that no significant drop in performance is to be expected due to this effect.

An Application of M[subscript 2] Statistic to Evaluate the Fit of Cognitive Diagnostic Models

ERIC Educational Resources Information Center

Liu, Yanlou; Tian, Wei; Xin, Tao

2016-01-01

The fit of cognitive diagnostic models (CDMs) to response data needs to be evaluated, since CDMs might yield misleading results when they do not fit the data well. Limited-information statistic M[subscript 2] and the associated root mean square error of approximation (RMSEA[subscript 2]) in item factor analysis were extended to evaluate the fit of…

Connection Domain Mutations in HIV-1 Reverse Transcriptase Do Not Impact Etravirine Susceptibility and Virologic Responses to Etravirine-Containing Regimens▿†

PubMed Central

Gupta, Soumi; Vingerhoets, Johan; Fransen, Signe; Tambuyzer, Lotke; Azijn, Hilde; Frantzell, Arne; Paredes, Roger; Coakley, Eoin; Nijs, Steven; Clotet, Bonaventura; Petropoulos, Christos J.; Schapiro, Jonathan; Huang, Wei; Picchio, Gaston

2011-01-01

Connection domain mutations (CDMs) in HIV-1 reverse transcriptase (RT) alter susceptibility to some nucleoside/nonnucleoside RT inhibitors (NRTIs/NNRTIs). Their effects on susceptibility and virologic responses to etravirine were analyzed. Seventeen CDMs were evaluated: L283I, E312Q, G333D, G333E, G335C, G335D, N348I, A360I, A360T, A360V, V365I, T369I, A371V, A376S, I393L, E399D, and E399G. CDM prevalence and effects on virologic responses were analyzed retrospectively using clinical data. The effects on etravirine susceptibility were assessed in clinical samples and confirmed using site-directed mutants. The most prevalent CDMs (>10%) were A371V, E399D, A376S, N348I, A360T, G333E, and L283I. CDM presence was positively correlated with thymidine analogue-associated mutations, but not with NNRTI resistance-associated mutations (RAMs). The presence or number of CDMs did not significantly reduce etravirine susceptibility, although small reductions were seen in samples with G333D, N348I, A360V, T369I, and A376S. N348I, E399G, and N348I/T369I were associated with reduced etravirine susceptibility when present with K103N, L100I, or Y181C. N348I or T369I was associated with reduced etravirine susceptibility when present with K101P or K103R/V179D. Virologic responses to an etravirine-containing regimen were slightly diminished when G333D, G335D, or A376S was present, but this was not confirmed in subgroups with higher baseline resistance or without etravirine RAMs. CDMs alone do not confer substantial reductions in etravirine susceptibility but can further reduce etravirine susceptibility in combination with certain NNRTI mutations. Since virologic responses to etravirine were not affected by CDMs, the clinical impacts of these mutations on etravirine susceptibility appear to be minimal. PMID:21464253

Short- and long-term clinical outcomes of use of beta-interferon or glatiramer acetate for people with clinically isolated syndrome: a systematic review of randomised controlled trials and network meta-analysis.

PubMed

Armoiry, X; Kan, A; Melendez-Torres, G J; Court, R; Sutcliffe, P; Auguste, P; Madan, J; Counsell, C; Clarke, A

2018-05-01

Beta-interferon (IFN-β) and glatiramer acetate (GA) have been evaluated in people with clinically isolated syndrome (CIS) with the aim to delay a second clinical attack and a diagnosis of clinically definite multiple sclerosis (CDMS). We systematically reviewed trials evaluating the short- and long-term clinical effectiveness of these drugs in CIS. We searched multiple electronic databases. We selected randomised controlled studies (RCTs) conducted in CIS patients and where the interventions were IFN-β and GA. Main outcomes were time to CDMS, and discontinuation due to adverse events (AE). We compared interventions using random-effect network meta-analyses (NMA). We also reported outcomes from long-term open-label extension (OLE) studies. We identified five primary studies. Four had open-label extensions following double-blind periods comparing outcomes between early vs delayed DMT. Short-term clinical results (double-blind period) showed that all drugs delayed CDMS compared to placebo. Indirect comparisons did not suggest superiority of any one active drug over another. We could not undertake a NMA for discontinuation due to AE. Long-term clinical results (OLE studies) showed that the risk of developing CDMS was consistently reduced across studies after early DMT treatment compared to delayed DMT (HR = 0.64, 95% CI 0.55, 0.74). No data supported the benefit of DMTs in reducing the time to, and magnitude of, disability progression. Meta-analyses confirmed that IFN-β and GA delay time to CDMS compared to placebo. In the absence of evidence that early DMTs can reduce disability progression, future research is needed to better identify patients most likely to benefit from long-term DMTs.

Applicability of McDonald 2010 and Magnetic Resonance Imaging in Multiple Sclerosis (MAGNIMS) 2016 Magnetic Resonance Imaging Criteria for the Diagnosis of Multiple Sclerosis in Sri Lanka.

PubMed

Gamage, Sujani Madhurika Kodagoda; Wijeweera, Indunil; Wijesinghe, Priyangi; Adikari, Sanjaya Bandara; Fink, Katharina; Sominanda, Herath Mudiyanselage Ajith

2018-05-31

The magnetic resonance imaging in multiple sclerosis (MAGNIMS) group recently proposed guidelines to replace the existing dissemination-in-space criteria in McDonald 2010 magnetic resonance imaging (MRI) criteria for diagnosing multiple sclerosis. There has been insufficient research regarding their applicability in Asians. Objective of this study was to determine the sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) of McDonald 2010 and MAGNIMS 2016 MRI criteria with the aim of verifying their applicability in Sri Lankan patients. Patients with clinically isolated syndrome diagnosed by consultant neurologists were recruited from five major neurology centers. Baseline and follow-up MRI scans were performed within 3 months from the initial presentation and at one year after baseline MRI, respectively. McDonald 2010 and MAGNIMS 2016 MRI criteria were applied to all MRI scans. Patients were followed-up for 2 years to assess the conversion to clinically definite multiple sclerosis (CDMS). The sensitivity, specificity, accuracy, PPV, and NPV for predicting the conversion to CDMS were calculated. Forty-two of 66 patients converted to CDMS. Thirty-seven fulfilled the McDonald 2010 MRI criteria, and 33 converted to CDMS. MAGNIMS 2016 MRI criteria were fulfilled by 29, with 28 converting to CDMS. The sensitivity, specificity, accuracy, PPV, and NPV were 78%, 83%, 64%, 89%, and 69%, respectively, for the McDonald 2010 criteria, and 67%, 96%, 77%, 96%, and 62% for the MAGNIMS 2016 MRI criteria. MAGNIMS 2016 MRI criteria were superior to McDonald 2010 MRI criteria in specificity, accuracy, and PPV, but inferior in sensitivity and NPV. Copyright © 2018 Korean Neurological Association.

Halo independent comparison of direct dark matter detection data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gondolo, Paolo; Gelmini, Graciela B., E-mail: paolo@physics.utah.edu, E-mail: gelmini@physics.ucla.edu

We extend the halo-independent method of Fox, Liu, and Weiner to include energy resolution and efficiency with arbitrary energy dependence, making it more suitable for experiments to use in presenting their results. Then we compare measurements and upper limits on the direct detection of low mass ( ∼ 10 GeV) weakly interacting massive particles with spin-independent interactions, including the upper limit on the annual modulation amplitude from the CDMS collaboration. We find that isospin-symmetric couplings are severely constrained both by XENON100 and CDMS bounds, and that isospin-violating couplings are still possible at the lowest energies, while the tension of themore » higher energy CoGeNT bins with the CDMS modulation constraint remains. We find the CRESST-II signal is not compatible with the modulation signals of DAMA and CoGeNT.« less

A Search for WIMP Dark Matter Using an Optimized Chi-square Technique on the Final Data from the Cryogenic Dark Matter Search Experiment (CDMS II)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Manungu Kiveni, Joseph

2012-12-01

This dissertation describes the results of a WIMP search using CDMS II data sets accumulated at the Soudan Underground Laboratory in Minnesota. Results from the original analysis of these data were published in 2009; two events were observed in the signal region with an expected leakage of 0.9 events. Further investigation revealed an issue with the ionization-pulse reconstruction algorithm leading to a software upgrade and a subsequent reanalysis of the data. As part of the reanalysis, I performed an advanced discrimination technique to better distinguish (potential) signal events from backgrounds using a 5-dimensional chi-square method. This dataanalysis technique combines themore » event information recorded for each WIMP-search event to derive a backgrounddiscrimination parameter capable of reducing the expected background to less than one event, while maintaining high efficiency for signal events. Furthermore, optimizing the cut positions of this 5-dimensional chi-square parameter for the 14 viable germanium detectors yields an improved expected sensitivity to WIMP interactions relative to previous CDMS results. This dissertation describes my improved (and optimized) discrimination technique and the results obtained from a blind application to the reanalyzed CDMS II WIMP-search data.« less

Report on Research in Experimental High Energy Physics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rusack, Roger W.; Cushman, Priscilla; Poling, Ronald

2016-01-06

In the past three years the groups supported by the DOE have all made significant progress and posted major successes. The Minnesota CMS group has played leading roles in five data analyses and has had major roles in detector operations, the data management and the detector upgrades that are planned for for the LHC and those that are planned for the high-luminosity LHC. The CDMS-II experiment held the lead in WIMP sensitivity over the last decade, and is still the most sensitive detector in the world in the low WIMP mass region, with a recent 3σ hint of 8 GeV/cmore » 2 WIMP candidates in the silicon data. SuperCDMS, with three orders of magnitude better electron recoil background rejection, has been collecting data since October 2011. Since all dark matter experiments require a better understanding of neutron backgrounds to make further advances in sensitivity, Cushman has expanded the Minnesota effort on backgrounds to the national level, where she is leading a coordinated effort in neutron simulations for underground physics. The work of Mandic on 100 mm detectors both for Super-CDMS and beyond has advanced rapidly. Also at the Intensity Frontier, the BESIII experiment has had a successful year of operation largely focused on searches for and studies of new "charmonium-like" states above DD threshold. At least one new state has been observed so far, with hints of others. An intensive effort to understand their nature and gain new insight into the strong interaction continues. BESIII has also produced a large number of other results in charmonium decay and light-hadronic physics.« less

Direct detection of light ''Ge-phobic'' exothermic dark matter

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gelmini, Graciela B.; Georgescu, Andreea; Huh, Ji-Haeng, E-mail: gelmini@physics.ucla.edu, E-mail: a.georgescu@physics.ucla.edu, E-mail: jhhuh@physics.ucla.edu

2014-07-01

We present comparisons of direct dark matter (DM) detection data for light WIMPs with exothermic scattering with nuclei (exoDM), both assuming the Standard Halo Model (SHM) and in a halo model–independent manner. Exothermic interactions favor light targets, thus reducing the importance of upper limits derived from xenon targets, the most restrictive of which is at present the LUX limit. In our SHM analysis the CDMS-II-Si and CoGeNT regions become allowed by these bounds, however the recent SuperCDMS limit rejects both regions for exoDM with isospin-conserving couplings. An isospin-violating coupling of the exoDM, in particular one with a neutron to protonmore » coupling ratio of -0.8 (which we call ''Ge-phobic''), maximally reduces the DM coupling to germanium and allows the CDMS-II-Si region to become compatible with all bounds. This is also clearly shown in our halo-independent analysis.« less

Interconnection of electronic medical record with clinical data management system by CDISC ODM.

PubMed

Matsumura, Yasushi; Hattori, Atsushi; Manabe, Shiro; Takeda, Toshihiro; Takahashi, Daiyo; Yamamoto, Yuichiro; Murata, Taizo; Mihara, Naoki

2014-01-01

EDC system has been used in the field of clinical research. The current EDC system does not connect with electronic medical record system (EMR), thus a medical staff has to transcribe the data in EMR to EDC system manually. This redundant process causes not only inefficiency but also human error. We developed an EDC system cooperating with EMR, in which the data required for a clinical research form (CRF) is transcribed automatically from EMR to electronic CRF (eCRF) and is sent via network. We call this system as "eCRF reporter". The interface module of eCRF reporter can retrieves the data in EMR database including patient biography data, laboratory test data, prescription data and data entered by template in progress notes. The eCRF reporter also enables users to enter data directly to eCRF. The eCRF reporter generates CDISC ODM file and PDF which is a translated form of Clinical data in ODM. After storing eCRF in EMR, it is transferred via VPN to a clinical data management system (CDMS) which can receive the eCRF files and parse ODM. We started some clinical research by using this system. This system is expected to promote clinical research efficiency and strictness.

Diagnostic value of brain chronic black holes on T1-weighted MR images in clinically isolated syndromes.

PubMed

Mitjana, Raquel; Tintoré, Mar; Rocca, Maria A; Auger, Cristina; Barkhof, Frederik; Filippi, Massimo; Polman, Chris; Fazekas, Franz; Huerga, Elena; Montalban, Xavier; Rovira, Alex

2014-10-01

Non-enhancing black holes (neBHs) are more common in multiple sclerosis (MS) patients with longer disease durations and progressive disease subtypes. Our aim was to analyse the added value of neBHs in patients with clinically isolated syndromes (CISs) for predicting conversion to clinically definite MS (CDMS). Patients were classified based on the presence or absence of neBHs and on the number of Barkhof-Tintoré (B-T) criteria fulfilled. Dissemination in space (DIS) was defined as the presence of at least three of the four B-T criteria. Dissemination in time (DIT)1 was defined by simultaneous presence of enhancing and non-enhancing lesions. DIT2 was defined by simultaneous presence of neBHs and T2 lesions not apparent on T1-weighted images. Focal T2-hyperintense brain lesions were identified in 87.7% of the 520 CIS patients, and 41.4% of them presented at least one neBH. Patients meeting DIS, DIT1, and DIT2 had a significantly higher rate of conversion to CDMS. After adjusting for DIS, only patients who fulfilled DIT1 preserved a significant increase in CDMS conversion. Non-enhancing black holes in CIS patients are associated with a higher risk of conversion to CDMS. However, the predictive value of this finding is lost when added to the DIS criteria. © The Author(s) 2014.

Improved Infrastucture for Cdms and JPL Molecular Spectroscopy Catalogues

NASA Astrophysics Data System (ADS)

Endres, Christian; Schlemmer, Stephan; Drouin, Brian; Pearson, John; Müller, Holger S. P.; Schilke, P.; Stutzki, Jürgen

2014-06-01

Over the past years a new infrastructure for atomic and molecular databases has been developed within the framework of the Virtual Atomic and Molecular Data Centre (VAMDC). Standards for the representation of atomic and molecular data as well as a set of protocols have been established which allow now to retrieve data from various databases through one portal and to combine the data easily. Apart from spectroscopic databases such as the Cologne Database for Molecular Spectroscopy (CDMS), the Jet Propulsion Laboratory microwave, millimeter and submillimeter spectral line catalogue (JPL) and the HITRAN database, various databases on molecular collisions (BASECOL, KIDA) and reactions (UMIST) are connected. Together with other groups within the VAMDC consortium we are working on common user tools to simplify the access for new customers and to tailor data requests for users with specified needs. This comprises in particular tools to support the analysis of complex observational data obtained with the ALMA telescope. In this presentation requests to CDMS and JPL will be used to explain the basic concepts and the tools which are provided by VAMDC. In addition a new portal to CDMS will be presented which has a number of new features, in particular meaningful quantum numbers, references linked to data points, access to state energies and improved documentation. Fit files are accessible for download and queries to other databases are possible.

Neurofilament light chain level is a weak risk factor for the development of MS

PubMed Central

Arrambide, Georgina; Eixarch, Herena; Villar, Luisa M.; Alvarez-Cermeño, José C.; Picón, Carmen; Kuhle, Jens; Disanto, Giulio; Kappos, Ludwig; Sastre-Garriga, Jaume; Pareto, Deborah; Simon, Eva; Comabella, Manuel; Río, Jordi; Nos, Carlos; Tur, Carmen; Castilló, Joaquín; Vidal-Jordana, Angela; Galán, Ingrid; Arévalo, Maria J.; Auger, Cristina; Rovira, Alex; Montalban, Xavier

2016-01-01

Objective: To determine the prognostic value of selected biomarkers in clinically isolated syndromes (CIS) for conversion to multiple sclerosis (MS) and disability accrual. Methods: Data were acquired from 2 CIS cohorts. The screening phase evaluated patients developing clinically definite MS (CIS-CDMS) and patients who remained as CIS during a 2-year minimum follow-up (CIS-CIS). We determined levels of neurofascin, semaphorin 3A, fetuin A, glial fibrillary acidic protein, and neurofilament light (NfL) and heavy chains in CSF (estimated mean [95% confidence interval; CI]). We evaluated associations between biomarker levels, conversion, disability, and magnetic resonance parameters. In the replication phase, we determined NfL levels (n = 155) using a 900 ng/L cutoff. Primary endpoints in uni- and multivariate analyses were CDMS and 2010 McDonald MS. Results: The only biomarker showing significant differences in the screening was NfL (CIS-CDMS 1,553.1 [1,208.7–1,897.5] ng/L and CIS-CIS 499.0 [168.8–829.2] ng/L, p < 0.0001). The strongest associations were with brain parenchymal fraction change (rs = −0.892) and percentage brain volume change (rs = −0.842) at 5 years. NfL did not correlate with disability. In the replication phase, more NfL-positive patients, according to the cutoff, evolved to MS. Every 100-ng/L increase in NfL predicted CDMS (hazard ratio [HR] = 1.009, 95% CI 1.005–1.014) and McDonald MS (HR = 1.009, 95% CI 1.005–1.013), remaining significant for CDMS in the multivariate analysis (adjusted HR = 1.005, 95% CI 1.000–1.011). This risk was lower than the presence of oligoclonal bands or T2 lesions. Conclusions: NfL is a weak independent risk factor for MS. Its role as an axonal damage biomarker may be more relevant as suggested by its association with medium-term brain volume changes. PMID:27521440

Contrast-guided image interpolation.

PubMed

Wei, Zhe; Ma, Kai-Kuang

2013-11-01

In this paper a contrast-guided image interpolation method is proposed that incorporates contrast information into the image interpolation process. Given the image under interpolation, four binary contrast-guided decision maps (CDMs) are generated and used to guide the interpolation filtering through two sequential stages: 1) the 45(°) and 135(°) CDMs for interpolating the diagonal pixels and 2) the 0(°) and 90(°) CDMs for interpolating the row and column pixels. After applying edge detection to the input image, the generation of a CDM lies in evaluating those nearby non-edge pixels of each detected edge for re-classifying them possibly as edge pixels. This decision is realized by solving two generalized diffusion equations over the computed directional variation (DV) fields using a derived numerical approach to diffuse or spread the contrast boundaries or edges, respectively. The amount of diffusion or spreading is proportional to the amount of local contrast measured at each detected edge. The diffused DV fields are then thresholded for yielding the binary CDMs, respectively. Therefore, the decision bands with variable widths will be created on each CDM. The two CDMs generated in each stage will be exploited as the guidance maps to conduct the interpolation process: for each declared edge pixel on the CDM, a 1-D directional filtering will be applied to estimate its associated to-be-interpolated pixel along the direction as indicated by the respective CDM; otherwise, a 2-D directionless or isotropic filtering will be used instead to estimate the associated missing pixels for each declared non-edge pixel. Extensive simulation results have clearly shown that the proposed contrast-guided image interpolation is superior to other state-of-the-art edge-guided image interpolation methods. In addition, the computational complexity is relatively low when compared with existing methods; hence, it is fairly attractive for real-time image applications.

Charge detection mass spectrometry: Instrumentation & applications to viruses

NASA Astrophysics Data System (ADS)

Pierson, Elizabeth E.

For over three decades, electrospray ionization (ESI) has been used to ionize non-covalent complexes and subsequently transfer the intact ion into the gas phase for mass spectrometry (MS) analysis. ESI generates a distribution of multiple charged ions, resulting in an m/z spectrum comprised of a series of peaks, known as a charge state envelope. To obtain mass information, the number of charges for each peak must be deduced. For smaller biological analytes like peptides, the charge states are sufficiently resolved and this process is straightforward. For macromolecular complexes exceeding ~100 kDa, this process is complicated by the broadening and shifting of charge states due to incomplete desolvation, salt adduction, and inherent mass heterogeneity. As the analyte mass approaches the MDa regime, the m/z spectrum is often comprised of a broad distribution of unresolved charge states. In such cases, mass determination is precluded. Charge detection mass spectrometry (CDMS) is an emerging MS technique for determining the masses of heterogeneous, macromolecular complexes. In CDMS, the m/z and z of single ions are measured concurrently so that mass is easily calculated. With this approach, deconvolution of an m/z spectrum is unnecessary. This measurement is carried out by passing macroions through a conductive cylinder. The induced image charge on the cylindrical detector provides information about m/z and z: the m/z is related to its time-of-flight through the detector, and the z is related to the intensity of the image charge. We have applied CDMS to study the self-assembly of virus capsids. Late-stage intermediates in the assembly of hepatitis B virus, a devastating human pathogen, have been identified. This is the first time that such intermediates have been detected and represent a significant advancement towards understanding virus capsid assembly. CDMS has also been used to identify oversized, non-icosahedral polymorphs in the assembly of woodchuck hepatitis virus capsids. Finally, CDMS has been used to characterize the purity of adeno-associated viral vectors for potential gene therapy applications.

Acquiring Structural Information on Virus Particles with Charge Detection Mass Spectrometry

NASA Astrophysics Data System (ADS)

Keifer, David Z.; Motwani, Tina; Teschke, Carolyn M.; Jarrold, Martin F.

2016-06-01

Charge detection mass spectrometry (CDMS) is a single-molecule technique particularly well-suited to measuring the mass and charge distributions of heterogeneous, MDa-sized ions. In this work, CDMS has been used to analyze the assembly products of two coat protein variants of bacteriophage P22. The assembly products show broad mass distributions extending from 5 to 15 MDa for A285Y and 5 to 25 MDa for A285T coat protein variants. Because the charge of large ions generated by electrospray ionization depends on their size, the charge can be used to distinguish hollow shells from more compact structures. A285T was found to form T = 4 and T = 7 procapsids, and A285Y makes a small number of T = 3 and T = 4 procapsids. Owing to the decreased stability of the A285Y and A285T particles, chemical cross-linking was required to stabilize them for electrospray CDMS. Graphical Abstract[Figure not available: see fulltext.

Improved WIMP-search reach of the CDMS II germanium data

DOE PAGES

Agnese, R.

2015-10-12

CDMS II data from the five-tower runs at the Soudan Underground Laboratory were reprocessed with an improved charge-pulse fitting algorithm. Two new analysis techniques to reject surface-event backgrounds were applied to the 612 kg days germanium-detector weakly interacting massive particle (WIMP)-search exposure. An extended analysis was also completed by decreasing the 10 keV analysis threshold to ~5 keV, to increase sensitivity near a WIMP mass of 8 GeV/c 2. After unblinding, there were zero candidate events above a deposited energy of 10 keV and six events in the lower-threshold analysis. This yielded minimum WIMP-nucleon spin-independent scattering cross-section limits of 1.8×10more » –44 and 1.18×10 –41 at 90% confidence for 60 and 8.6 GeV/c 2 WIMPs, respectively. This improves the previous CDMS II result by a factor of 2.4 (2.7) for 60 (8.6) GeV/c 2 WIMPs.« less

Improved WIMP-search reach of the CDMS II germanium data

DOE PAGES

Agnese, R.

2015-10-12

CDMS II data from the five-tower runs at the Soudan Underground Laboratory were reprocessed with an improved charge-pulse fitting algorithm. Two new analysis techniques to reject surface-event backgrounds were applied to the 612 kg days germanium-detector weakly interacting massive particle (WIMP)-search exposure. An extended analysis was also completed by decreasing the 10 keV analysis threshold to ~5 keV, to increase sensitivity near a WIMP mass of 8 GeV/c 2. After unblinding, there were zero candidate events above a deposited energy of 10 keV and six events in the lower-threshold analysis. This yielded minimum WIMP-nucleon spin-independent scattering cross-section limits of 1.8×10more » –44 and 1.18×10 –41 at 90% confidence for 60 and 8.6 GeV/c 2 WIMPs, respectively. Furthermore, this improves the previous CDMS II result by a factor of 2.4 (2.7) for 60 (8.6) GeV/c 2 WIMPs.« less

Direct detection of exothermic dark matter with light mediator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Geng, Chao-Qiang; Department of Physics, National Tsing Hua University,Hsinchu, Taiwan; Physics Division, National Center for Theoretical Sciences,Hsinchu, Taiwan

2016-08-05

We study the dark matter (DM) direct detection for the models with the effects of the isospin-violating couplings, exothermic scatterings, and/or the lightness of the mediator, proposed to relax the tension between the CDMS-Si signals and null experiments. In the light of the new updates of the LUX and CDMSlite data, we find that many of the previous proposals are now ruled out, including the Ge-phobic exothermic DM model and the Xe-phobic DM one with a light mediator. We also examine the exothermic DM models with a light mediator but without the isospin violation, and we are unable to identifymore » any available parameter space that could simultaneously satisfy all the experiments. The only models that can partially relax the inconsistencies are the Xe-phobic exothermic DM models with or without a light mediator. But even in this case, a large portion of the CDMS-Si regions of interest has been constrained by the LUX and SuperCDMS data.« less

Direct detection of light “Ge-phobic” exothermic dark matter

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gelmini, Graciela B.; Georgescu, Andreea; Huh, Ji-Haeng

2014-07-15

We present comparisons of direct dark matter (DM) detection data for light WIMPs with exothermic scattering with nuclei (exoDM), both assuming the Standard Halo Model (SHM) and in a halo model — independent manner. Exothermic interactions favor light targets, thus reducing the importance of upper limits derived from xenon targets, the most restrictive of which is at present the LUX limit. In our SHM analysis the CDMS-II-Si and CoGeNT regions become allowed by these bounds, however the recent SuperCDMS limit rejects both regions for exoDM with isospin-conserving couplings. An isospin-violating coupling of the exoDM, in particular one with a neutronmore » to proton coupling ratio of −0.8 (which we call “Ge-phobic”), maximally reduces the DM coupling to germanium and allows the CDMS-II-Si region to become compatible with all bounds. This is also clearly shown in our halo-independent analysis.« less

Determining Energies and Cross Sections of Individual Ions Using Higher-Order Harmonics in Fourier Transform Charge Detection Mass Spectrometry (FT-CDMS)

NASA Astrophysics Data System (ADS)

Harper, Conner C.; Elliott, Andrew G.; Lin, Haw-Wei; Williams, Evan R.

2018-06-01

A general method for in situ measurements of the energy of individual ions trapped and weighed using charge detection mass spectrometry (CDMS) is described. Highly charged (> 300 e), individual polyethylene glycol (PEG) ions are trapped and oscillate within an electrostatic trap, producing a time domain signal. A segmented Fourier transform (FT) of this signal yields the temporal evolution of the fundamental and harmonic frequencies of ion motion throughout the 500-ms trap time. The ratio of the fundamental frequency and second harmonic (HAR) depends on the ion energy, which is an essential parameter for measuring ion mass in CDMS. This relationship is calibrated using simulated ion signals, and the calibration is compared to the HAR values measured for PEG ion signals where the ion energy was also determined using an independent method that requires that the ions be highly charged (> 300 e). The mean error of 0.6% between the two measurements indicates that the HAR method is an accurate means of ion energy determination that does not depend on ion size or charge. The HAR is determined dynamically over the entire trapping period, making it possible to observe the change in ion energy that takes place as solvent evaporates from the ion and collisions with background gas occur. This method makes it possible to measure mass changes, either from solvent evaporation or from molecular fragmentation (MSn), as well as the cross sections of ions measured using CDMS.

Thermal conductance measurements of bolted copper joints for SuperCDMS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schmitt, R.; Tatkowski, Greg; Ruschman, M.

2015-09-01

Joint thermal conductance testing has been undertaken for bolted copper to copper connections from 60 mK to 26 K. This testing was performed to validate an initial design basis for the SuperCDMS experiment, where a dilution refrigerator will be coupled to a cryostat via multiple bolted connections. Copper used during testing was either gold plated or passivated with citric acid to prevent surface oxidation. Results obtained are well fit by a power law regression of joint thermal conductance to temperature and match well with data collected during a literature review.

A Q-backpropagated time delay neural network for diagnosing severity of gait disturbances in Parkinson's disease.

PubMed

Nancy Jane, Y; Khanna Nehemiah, H; Arputharaj, Kannan

2016-04-01

Parkinson's disease (PD) is a movement disorder that affects the patient's nervous system and health-care applications mostly uses wearable sensors to collect these data. Since these sensors generate time stamped data, analyzing gait disturbances in PD becomes challenging task. The objective of this paper is to develop an effective clinical decision-making system (CDMS) that aids the physician in diagnosing the severity of gait disturbances in PD affected patients. This paper presents a Q-backpropagated time delay neural network (Q-BTDNN) classifier that builds a temporal classification model, which performs the task of classification and prediction in CDMS. The proposed Q-learning induced backpropagation (Q-BP) training algorithm trains the Q-BTDNN by generating a reinforced error signal. The network's weights are adjusted through backpropagating the generated error signal. For experimentation, the proposed work uses a PD gait database, which contains gait measures collected through wearable sensors from three different PD research studies. The experimental result proves the efficiency of Q-BP in terms of its improved classification accuracy of 91.49%, 92.19% and 90.91% with three datasets accordingly compared to other neural network training algorithms. Copyright © 2016 Elsevier Inc. All rights reserved.

Determining Energies and Cross Sections of Individual Ions Using Higher-Order Harmonics in Fourier Transform Charge Detection Mass Spectrometry (FT-CDMS).

PubMed

Harper, Conner C; Elliott, Andrew G; Lin, Haw-Wei; Williams, Evan R

2018-06-02

A general method for in situ measurements of the energy of individual ions trapped and weighed using charge detection mass spectrometry (CDMS) is described. Highly charged (> 300 e), individual polyethylene glycol (PEG) ions are trapped and oscillate within an electrostatic trap, producing a time domain signal. A segmented Fourier transform (FT) of this signal yields the temporal evolution of the fundamental and harmonic frequencies of ion motion throughout the 500-ms trap time. The ratio of the fundamental frequency and second harmonic (HAR) depends on the ion energy, which is an essential parameter for measuring ion mass in CDMS. This relationship is calibrated using simulated ion signals, and the calibration is compared to the HAR values measured for PEG ion signals where the ion energy was also determined using an independent method that requires that the ions be highly charged (> 300 e). The mean error of 0.6% between the two measurements indicates that the HAR method is an accurate means of ion energy determination that does not depend on ion size or charge. The HAR is determined dynamically over the entire trapping period, making it possible to observe the change in ion energy that takes place as solvent evaporates from the ion and collisions with background gas occur. This method makes it possible to measure mass changes, either from solvent evaporation or from molecular fragmentation (MS n ), as well as the cross sections of ions measured using CDMS. Graphical Abstract.

Measurement of SQUID noise levels for SuperCDMS SNOLAB detectors - Final Paper

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, Maxwell

SuperCDMS SNOLAB is a second generation direct dark matter search. In the SuperCDMS SNOLAB experiment, detectors are able to pick up from signals from dark matter nuclear recoil interactions which occur inside the bulk of the detectors. These interactions produce both phonon and charge signals. HEMTs read out charge signals whereas TES are used to detect phonon signals which are then read out by SQUID amplifiers. SQUID amplifiers must add negligible noise to the TES intrinsic noise which has been previously measured and is approximately 50pA/√Hz down to 100Hz for ease of signal distinguishability in dark matter nuclear interactions. Themore » intrinsic noise level of the SQUID was tested in the SLAC 300mK fridge and determined to provide adequately low levels of noise with a floor of approximately 3pA/√Hz. Furthermore, a 10x amplifier was tested for addition of extraneous noise. This noise was investigated with and without this amplifier, and it was found that it did not add a significant amount of noise to the intrinsic SQUID noise.« less

Thermal conductance measurements of bolted copper joints for SuperCDMS

DOE PAGES

Schmitt, R. L.; Tatkowski, G.; Ruschman, M.; ...

2015-04-28

Joint thermal conductance testing has been undertaken for bolted copper to copper connections from 60 mK to 26 K. This testing was performed to validate an initial design basis for the SuperCDMS experiment, where a dilution refrigerator will be coupled to a cryostat via multiple bolted connections. Copper used during testing was either gold plated or passivated with citric acid to prevent surface oxidation. Finally, the results we obtained are well fit by a power law regression of joint thermal conductance to temperature and match well with data collected during a literature review.

Direct Determination of Molecular Weight Distribution of Calf-Thymus DNAs and Study of Their Fragmentation under Ultrasonic and Low-Energy IR Irradiations. A Charge Detection Mass Spectrometry Investigation.

PubMed

Halim, Mohammad A; Bertorelle, Franck; Doussineau, Tristan; Antoine, Rodolphe

2018-06-09

Calf-thymus (CT-DNA) is widely used as binding agent. The commercial samples are known to be "highly polymerized DNA" samples. CT-DNA is known to be fragile in particular upon ultrasonic wave irradiation. Degradation products might have dramatic consequence on its bio-sensing activity, and an accurate determination of the molecular weight distribution and stability of commercial samples is highly demanded. We investigated the sensitivity of charge detection mass spectrometry (CDMS), a single-molecule MS method, both with single-pass and ion trap CDMS ("Benner" trap) modes to the determination of the composition and stability (under multiphoton IR irradiation) of calf-thymus DNAs. We also investigated the changes of molecular weight distributions in the course of sonication by irradiating ultrasonic wave to CT-DNA. We report for the first time, the direct molecular weight (MW) distribution of DNA sodium salt from calf-thymus revealing two populations at high (~10 MDa) and low (~3 MDa) molecular weights. We evidence a transition between the high-MW to the low-MW distribution, confirming that the low-MW distribution results from degradation of CT-DNA. Finally, we report also IRMPD experiments carried out on trapped single-stranded linear DNAs from calf-thymus allowing to extract their activation energy for unimolecular dissociation. We show that single-pass CDMS is a direct, efficient and accurate MS-based approach to determine the composition of calf-thymus DNAs. Furthermore, ion trap CDMS allows us to evaluate the stability (both under multiphoton IR irradiation and in the course of sonication by irradiating ultrasonic wave) of calf-thymus DNAs. This article is protected by copyright. All rights reserved.

Clinical data integration of distributed data sources using Health Level Seven (HL7) v3-RIM mapping

PubMed Central

2011-01-01

Background Health information exchange and health information integration has become one of the top priorities for healthcare systems across institutions and hospitals. Most organizations and establishments implement health information exchange and integration in order to support meaningful information retrieval among their disparate healthcare systems. The challenges that prevent efficient health information integration for heterogeneous data sources are the lack of a common standard to support mapping across distributed data sources and the numerous and diverse healthcare domains. Health Level Seven (HL7) is a standards development organization which creates standards, but is itself not the standard. They create the Reference Information Model. RIM is developed by HL7's technical committees. It is a standardized abstract representation of HL7 data across all the domains of health care. In this article, we aim to present a design and a prototype implementation of HL7 v3-RIM mapping for information integration of distributed clinical data sources. The implementation enables the user to retrieve and search information that has been integrated using HL7 v3-RIM technology from disparate health care systems. Method and results We designed and developed a prototype implementation of HL7 v3-RIM mapping function to integrate distributed clinical data sources using R-MIM classes from HL7 v3-RIM as a global view along with a collaborative centralized web-based mapping tool to tackle the evolution of both global and local schemas. Our prototype was implemented and integrated with a Clinical Database management Systems CDMS as a plug-in module. We tested the prototype system with some use case scenarios for distributed clinical data sources across several legacy CDMS. The results have been effective in improving information delivery, completing tasks that would have been otherwise difficult to accomplish, and reducing the time required to finish tasks which are used in collaborative information retrieval and sharing with other systems. Conclusions We created a prototype implementation of HL7 v3-RIM mapping for information integration between distributed clinical data sources to promote collaborative healthcare and translational research. The prototype has effectively and efficiently ensured the accuracy of the information and knowledge extractions for systems that have been integrated PMID:22104558

New Results from the Search for Low-Mass Weakly Interacting Massive Particles with the CDMS Low Ionization Threshold Experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Agnese, R.; Anderson, A. J.; Aramaki, T.

2016-02-01

The CDMS low ionization threshold experiment (CDMSlite) uses cryogenic germanium detectors operated at a relatively high bias voltage to amplify the phonon signal in the search for weakly interacting massive particles (WIMPs). Results are presented from the second CDMSlite run with an exposure of 70 kg day, which reached an energy threshold for electron recoils as low as 56 eV. A fiducialization cut reduces backgrounds below those previously reported by CDMSlite. New parameter space for the WIMP-nucleon spin-independent cross section is excluded for WIMP masses between 1.6 and 5.5 GeV/c^2.

Measurement of Nuclear Recoils in the CDMS II Dark Matter Search

NASA Astrophysics Data System (ADS)

Fallows, Scott M.

The Cryogenic Dark Matter Search (CDMS) experiment is designed to directly detect elastic scatters of weakly-interacting massive dark matter particles (WIMPs), on target nuclei in semiconductor crystals composed of Si and Ge. These scatters would occur very rarely, in an overwhelming background composed primarily of electron recoils from photons and electrons, as well as a smaller but non-negligible background of WIMP-like nuclear recoils from neutrons. The CDMS~II generation of detectors simultaneously measure ionization and athermal phonon signals from each scatter, allowing discrimination against virtually all electron recoils in the detector bulk. Pulse-shape timing analysis allows discrimination against nearly all remaining electron recoils taking place near detector surfaces. Along with carefully limited neutron backgrounds, this experimental program allowed for "background-free'' operation of CDMS~II at Soudan, with less than one background event expected in each WIMP-search analysis. As a result, exclusionary upper-limits on WIMP-nucleon interaction cross section were placed over a wide range of candidate WIMP masses, ruling out large new regions of parameter space. These results, like any others, are subject to a variety of systematic effects that may alter their final interpretations. A primary focus of this dissertation will be difficulties in precisely calibrating the energy scale for nuclear recoil events like those from WIMPs. Nuclear recoils have suppressed ionization signals relative to electron recoils of the same recoil energy, so the response of the detectors is calibrated differently for each recoil type. The overall normalization and linearity of the energy scale for electron recoils in CDMS~II detectors is clearly established by peaks of known gamma energy in the ionization spectrum of calibration data from a 133Ba source. This electron-equivalent keVee) energy scale enables calibration of the total phonon signal (keVt) by enforcing unity yield for electron recoils, in aggregate. Subtracting an event's Luke phonon contribution from its calibrated total phonon energy (keV t), as measured by the ionization signal, results in a valid measure of the true recoil energy (keVr) for both electron and nuclear recoils. I discuss systematic uncertainties affecting the reconstruction of this recoil energy, the primary analysis variable, and use several methods to constrain their magnitude. I present the resulting adjusted WIMP limits and discuss their impact in the context of current and projected constraints on the parameter space for WIMP interactions.

Subcutaneous interferon β-1a in the treatment of clinically isolated syndromes: 3-year and 5-year results of the phase III dosing frequency-blind multicentre REFLEXION study.

PubMed

Comi, Giancarlo; De Stefano, Nicola; Freedman, Mark S; Barkhof, Frederik; Uitdehaag, Bernard M J; de Vos, Marlieke; Marhardt, Kurt; Chen, Liang; Issard, Delphine; Kappos, Ludwig

2017-04-01

Early treatment following a first clinical demyelinating event (FCDE) delays further disease activity in patients with multiple sclerosis (MS). This study determined the effects of early versus delayed treatment (DT) with subcutaneous interferon (sc IFN) β-1a 44 μg in patients with an FCDE up to 60 months postrandomisation. Patients who completed the 24-month double-blind REFLEX (REbif FLEXible dosing in early MS) study entered an extension (REFLEXION, REbif FLEXible dosing in early MS extensION): patients initially randomised to sc IFN β-1a and not reaching clinically definite MS (clinically definite MS, CDMS (second attack or sustained Expanded Disability Status Scale (EDSS) score increase)) continued original treatment (three times weekly (tiw) or once weekly (qw)); placebo patients switched to tiw (DT); patients with CDMS switched to tiw. Clinical, MRI and adverse event data up to month 60 are reported. 402/517 (77.8%) REFLEX patients entered REFLEXION (DT, n=133; tiw, n=127; qw, n=142). At month 60, cumulative probability of CDMS was: DT 44.6%; qw 40.7% (nominal p=0.084 vs DT); tiw 39.2% (nominal p=0.032 vs DT). Cumulative probability of McDonald MS conversion (CDMS or new MRI activity) at month 60 was also reduced for tiw versus DT (nominal p<0.001). At month 60, mean cumulative numbers of new T2, gadolinium-enhancing and T1 hypointense lesions were lower with sc IFN β-1a qw (nominal p<0.05) and tiw versus DT (nominal p<0.001); T2 and T1 hypointense lesion volume change was lower for sc IFN β-1a tiw versus DT (nominal p<0.01). Treatment was well tolerated; fewer patients receiving tiw versus qw were positive for neutralising or binding antibodies. Over 5 years in patients presenting with an FCDE, early sc IFN β-1a tiw administration versus DT prolonged time to CDMS and McDonald MS, and reduced overall MRI activity. NCT00813709; Results. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

A simple versatile solution for collecting multidimensional clinical data based on the CakePHP web application framework.

PubMed

Biermann, Martin

2014-04-01

Clinical trials aiming for regulatory approval of a therapeutic agent must be conducted according to Good Clinical Practice (GCP). Clinical Data Management Systems (CDMS) are specialized software solutions geared toward GCP-trials. They are however less suited for data management in small non-GCP research projects. For use in researcher-initiated non-GCP studies, we developed a client-server database application based on the public domain CakePHP framework. The underlying MySQL database uses a simple data model based on only five data tables. The graphical user interface can be run in any web browser inside the hospital network. Data are validated upon entry. Data contained in external database systems can be imported interactively. Data are automatically anonymized on import, and the key lists identifying the subjects being logged to a restricted part of the database. Data analysis is performed by separate statistics and analysis software connecting to the database via a generic Open Database Connectivity (ODBC) interface. Since its first pilot implementation in 2011, the solution has been applied to seven different clinical research projects covering different clinical problems in different organ systems such as cancer of the thyroid and the prostate glands. This paper shows how the adoption of a generic web application framework is a feasible, flexible, low-cost, and user-friendly way of managing multidimensional research data in researcher-initiated non-GCP clinical projects. Copyright © 2014 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.

New results from the search for low-mass weakly interacting massive particles with the CDMS low ionization threshold experiment

DOE PAGES

Agnese, R.

2016-02-17

The CDMS low ionization threshold experiment (CDMSlite) uses cryogenic germanium detectors operated at a relatively high bias voltage to amplify the phonon signal in the search for weakly interacting massive particles (WIMPs). Our results are presented from the second CDMSlite run with an exposure of 70 kg days, which reached an energy threshold for electron recoils as low as 56 eV. Furthermore, a fiducialization cut reduces backgrounds below those previously reported by CDMSlite. Lastly, new parameter space for the WIMP-nucleon spin-independent cross section is excluded forWIMP masses between 1.6 and 5.5 GeV/c 2.

Creating a Common Data Model for Comparative Effectiveness with the Observational Medical Outcomes Partnership.

PubMed

FitzHenry, F; Resnic, F S; Robbins, S L; Denton, J; Nookala, L; Meeker, D; Ohno-Machado, L; Matheny, M E

2015-01-01

Adoption of a common data model across health systems is a key infrastructure requirement to allow large scale distributed comparative effectiveness analyses. There are a growing number of common data models (CDM), such as Mini-Sentinel, and the Observational Medical Outcomes Partnership (OMOP) CDMs. In this case study, we describe the challenges and opportunities of a study specific use of the OMOP CDM by two health systems and describe three comparative effectiveness use cases developed from the CDM. The project transformed two health system databases (using crosswalks provided) into the OMOP CDM. Cohorts were developed from the transformed CDMs for three comparative effectiveness use case examples. Administrative/billing, demographic, order history, medication, and laboratory were included in the CDM transformation and cohort development rules. Record counts per person month are presented for the eligible cohorts, highlighting differences between the civilian and federal datasets, e.g. the federal data set had more outpatient visits per person month (6.44 vs. 2.05 per person month). The count of medications per person month reflected the fact that one system's medications were extracted from orders while the other system had pharmacy fills and medication administration records. The federal system also had a higher prevalence of the conditions in all three use cases. Both systems required manual coding of some types of data to convert to the CDM. The data transformation to the CDM was time consuming and resources required were substantial, beyond requirements for collecting native source data. The need to manually code subsets of data limited the conversion. However, once the native data was converted to the CDM, both systems were then able to use the same queries to identify cohorts. Thus, the CDM minimized the effort to develop cohorts and analyze the results across the sites.

Constraints on light mediators: Confronting dark matter searches with B physics

NASA Astrophysics Data System (ADS)

Schmidt-Hoberg, Kai; Staub, Florian; Winkler, Martin Wolfgang

2013-12-01

Light scalars appear in many well-motivated extensions of the Standard Model including supersymmetric models with additional gauge singlets. Such scalars could mediate the interactions between dark matter and nuclei, giving rise to the tentative signals observed by several dark matter direct detection experiments including CDMS-Si. In this Letter, we derive strong new limits on light scalar mediators by using the LHCb, Belle and BaBar searches for rare ϒ and B decays. These limits rule out significant parts of the parameter space favored by CDMS-Si. Nevertheless, as current searches are not optimized for investigating weakly coupled light scalars, a further increase in experimental sensitivity could be achieved by relaxing requirements in the event selection.

Dark matter effective field theory scattering in direct detection experiments

DOE PAGES

Schneck, K.

2015-05-01

We examine the consequences of the effective field theory (EFT) of dark matter–nucleon scattering for current and proposed direct detection experiments. Exclusion limits on EFT coupling constants computed using the optimum interval method are presented for SuperCDMS Soudan, CDMS II, and LUX, and the necessity of combining results from multiple experiments in order to determine dark matter parameters is discussed. We demonstrate that spectral differences between the standard dark matter model and a general EFT interaction can produce a bias when calculating exclusion limits and when developing signal models for likelihood and machine learning techniques. We also discuss the implicationsmore » of the EFT for the next-generation (G2) direct detection experiments and point out regions of complementarity in the EFT parameter space.« less

Dark matter effective field theory scattering in direct detection experiments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schneck, K.; Cabrera, B.; Cerdeño, D. G.

2015-05-18

We examine the consequences of the effective field theory (EFT) of dark matter-nucleon scattering for current and proposed direct detection experiments. Exclusion limits on EFT coupling constants computed using the optimum interval method are presented for SuperCDMS Soudan, CDMS II, and LUX, and the necessity of combining results from multiple experiments in order to determine dark matter parameters is discussed. Here. we demonstrate that spectral differences between the standard dark matter model and a general EFT interaction can produce a bias when calculating exclusion limits and when developing signal models for likelihood and machine learning techniques. In conclusion, we discussmore » the implications of the EFT for the next-generation (G2) direct detection experiments and point out regions of complementarity in the EFT parameter space.« less

Dark matter effective field theory scattering in direct detection experiments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schneck, K.; Cabrera, B.; Cerdeño, D. G.

2015-05-18

We examine the consequences of the effective field theory (EFT) of dark matter–nucleon scattering for current and proposed direct detection experiments. Exclusion limits on EFT coupling constants computed using the optimum interval method are presented for SuperCDMS Soudan, CDMS II, and LUX, and the necessity of combining results from multiple experiments in order to determine dark matter parameters is discussed. We demonstrate that spectral differences between the standard dark matter model and a general EFT interaction can produce a bias when calculating exclusion limits and when developing signal models for likelihood and machine learning techniques. We also discuss the implicationsmore » of the EFT for the next-generation (G2) direct detection experiments and point out regions of complementarity in the EFT parameter space.« less

Study on Spacelab software development and integration concepts

NASA Technical Reports Server (NTRS)

1974-01-01

A study was conducted to define the complexity and magnitude of the Spacelab software challenge. The study was based on current Spacelab program concepts, anticipated flight schedules, and ground operation plans. The study was primarily directed toward identifying and solving problems related to the experiment flight application and tests and checkout software executing in the Spacelab onboard command and data management subsystem (CDMS) computers and electrical ground support equipment (EGSE). The study provides a conceptual base from which it is possible to proceed into the development phase of the Software Test and Integration Laboratory (STIL) and establishes guidelines for the definition of standards which will ensure that the total Spacelab software is understood prior to entering development.

The cryogenic dark matter search low ionization-threshold experiment

NASA Astrophysics Data System (ADS)

Basu Thakur, Ritoban

Over 80 years ago we discovered the presence of Dark Matter in our universe. Endeavors in astronomy and cosmology are in consensus with ever improving precision that Dark Matter constitutes an essential 27% of our universe. The Standard Model of Particle Physics does not provide any answers to the Dark Matter problem. It is imperative that we understand Dark Matter and discover its fundamental nature. This is because, alongside other important factors, Dark Matter is responsible for formation of structure in our universe. The very construct in which we sit is defined by its abundance. The Milky Way galaxy, hence life, wouldn't have formed if small over densities of Dark Matter had not caused sufficient accretion of stellar material. Marvelous experiments have been designed based on basic notions to directly and indirectly study Dark Matter, and the Cryogenic Dark Matter Search (CDMS) experiment has been a pioneer and forerunner in the direct detection field. Generations of the CDMS experiment were designed with advanced scientific upgrades to detect Dark Matter particles of mass O(100) GeV/c2. This mass-scale was set primarily by predictions from Super Symmetry. Around 2013 the canonical SUSY predictions were losing some ground and several observations (rather hints of signals) from various experiments indicated to the possibility of lighter Dark Matter of mass O(10) GeV/c2. While the SuperCDMS experiment was probing the regular parameter space, the CDMSlite experiment was conceived to dedicatedly search for light Dark Matter using a novel technology. "CDMSlite" stands for CDMS - low ionization threshold experiment. Here we utilize a unique electron phonon coupling mechanism to measure ionization generated by scattering of light particles. Typically signals from such low energy recoils would be washed under instrumental noise.In CDMSlite via generation of Luke-Neganov phonons we can detect the small ionization energies, amplified in phonon modes during charge transport. This technology allows us to reach very low thresholds and reliably measure and investigate low energy recoils from light Dark Matter particles. This thesis describes the physics behind CDMSlite, the experimenta design and the first science results from CDMSlite operated at the Soudan Underground Laboratory.

The Cryogenic Dark Matter Search low ionization-threshold experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Basu Thakur, Ritoban

2014-01-01

Over 80 years ago we discovered the presence of Dark Matter in our universe. Endeavors in astronomy and cosmology are in consensus with ever improving precision that Dark Matter constitutes an essential 27% of our universe. The Standard Model of Particle Physics does not provide any answers to the Dark Matter problem. It is imperative that we understand Dark Matter and discover its fundamental nature. This is because, alongside other important factors, Dark Matter is responsible for formation of structure in our universe. The very construct in which we sit is defined by its abundance. The Milky Way galaxy, hencemore » life, wouldn't have formed if small over densities of Dark Matter had not caused sufficient accretion of stellar material. Marvelous experiments have been designed based on basic notions to directly and in-directly study Dark Matter, and the Cryogenic Dark Matter Search (CDMS) experiment has been a pioneer and forerunner in the direct detection field. Generations of the CDMS experiment were designed with advanced scientific upgrades to detect Dark Matter particles of mass O(100) GeV/c 2. This mass-scale was set primarily by predictions from Super Symmetry. Around 2013 the canonical SUSY predictions were losing some ground and several observations (rather hints of signals) from various experiments indicated to the possibility of lighter Dark Matter of mass O(10) GeV/c 2. While the SuperCDMS experiment was probing the regular parameter space, the CDMSlite experiment was conceived to dedicatedly search for light Dark Matter using a novel technology. "CDMSlite" stands for CDMS - low ionization threshold experiment. Here we utilize a unique electron phonon coupling mechanism to measure ionization generated by scattering of light particles. Typically signals from such low energy recoils would be washed under instrumental noise. In CDMSlite via generation of Luke-Neganov phonons we can detect the small ionization energies, amplified in phonon modes during charge transport. This technology allows us to reach very low thresholds and reliably measure and investigate low energy recoils from light Dark Matter particles. This thesis describes the physics behind CDMSlite, the experimental design and the first science results from CDMSlite operated at the Soudan Underground Laboratory.« less

Screening materials with the XIA UltraLo alpha particle counter at Southern Methodist University

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nakib, M. Z.; Cooley, J.; Kara, B.

2013-08-08

Southern Methodist University houses one of five existing commercially available UltraLo 1800 production model alpha counters made by XIA LLC. The instrument has an electron drift chamber with a 707 cm{sup 2} or 1800 cm{sup 2} counting region which is determined by selecting the inner electrode size. The SMU team operating this device is part of the SuperCDMS screening working group, and uses the alpha counter to study the background rates from the decay of radon in materials used to construct the SuperCDMS experiment. We have studied four acrylic samples obtained from the MiniCLEAN direct dark matter search with themore » XIA instrument demonstrating its utility in low background experiments by investigating the plate-out of {sup 210}Pb and comparing the effectiveness of cleaning procedures in removing {sup 222}Rn progenies from the samples.« less

Conjunction Assessment for Commercial Satellite Constellations Using Commercial Radar Data Sources

NASA Astrophysics Data System (ADS)

Nicolls, M.; Vittaldev, V.; Ceperley, D.; Creus-Costa, J.; Foster, C.; Griffith, N.; Lu, E.; Mason, J.; Park, I.; Rosner, C.; Stepan, L.

For companies with multiple orbital assets, managing the risk of collision with other low-Earth orbit (LEO) Resident Space Objects (RSOs) can amount to a significant operational burden. LeoLabs and Planet investigate the impact of a workflow that integrates commercial Space Situational Awareness (SSA) data into conjunction assessments for large satellite constellations. Radar measurements from LeoLabs are validated against truth orbits provided by the International Laser Ranging Service (ILRS) and to measurements from Planet’s on-board GPS instrumentation. The radar data is then used as input for orbit fits in order to form the basis of a conjunction assessment. To confirm the reliability of the orbit determination (OD), the generated ephemerides are validated against ILRS and GPS-derived orbits. In addition, a covariance realism assessment is performed in order to check for self-consistency by comparing the propagated orbit and the associated covariance against later measurements. Several cases are investigated to assess the benefits of integrating radar-derived products with Conjunction Data Messages (CDMs) received on Planet spacecraft. Conjunction assessment is refined using onboard GPS measurements from Planet satellites along with tracking measurements of the secondary RSO by LeoLabs. This study demonstrates that commercial data provided by LeoLabs is reliable, accurate, and timely, and that ephemeris generated from LeoLabs data provides solutions and insights which are consistent with those provided in CDMs. For the cases analyzed, the addition of commercial SSA data from LeoLabs has a positive impact on operations due to the additional information on the state of the secondary RSO which can lead to increased confidence in any maneuver-related decisions. Measurements from LeoLabs can also be used to improve conjunction assessment for commercial satellites that do not have any operator OD.

A Search for WIMP Dark Matter using an Optimized Chi-square Technique on the Final Data from the Cryogenic Dark Matter Search Experiment (CDMS II)

NASA Astrophysics Data System (ADS)

Manungu Kiveni, Joseph

2012-06-01

During the last two decades, cosmology has become a precision observational science thanks (in part) to the incredible number of experiments performed to better understand the composition of the universe. The large amount of data accumulated strongly indicates that the bulk of the universe's matter is in the form of non-baryonic matter that does not interact electromagnetically. Combined evidence from the dynamics of galaxies and galaxy clusters confirms that most of the mass in the universe is not composed of any known form of matter. Measurements of the cosmic microwave background, big bang nucleosynthesis and many other experiments indicate that ˜80% of the matter in the universe is dark, non-relativistic and cold. The dark matter resides in the halos surrounding galaxies, galaxy clusters and other large-scale structures. Weakly Interacting Massive Particles (WIMPs) are well motivated class of dark matter candidates that arise naturally in supersymmetric extensions to the Standard Model of particles physics, and can be produced as non-relativistic thermal relics in the early universe with about the right density to account for the missing mass. The Cryogenic Dark Matter Search (CDMS) experiment seeks to directly detect the keV-scale energy deposited by WIMPs in the galactic halo when they scatter from nuclei in the crystalline detectors made of germanium and silicon. These detectors, called Z-sensitive Ionization and Phonon detectors (ZIPs) are operated at ˜ 45 mK and simultaneously measure the ionization and the (athermal) phonons produced by particle interactions. The ratio of ionization and phonon energies allows discrimination of a low rate of nuclear recoils (expected for WIMPs) from an overwhelming rate of electron recoils (expected for most backgrounds). Phonon-pulse shape and timing enables further suppression of lower-rate interactions at the detector surfaces. This dissertation describes the results of a WIMP search using CDMS II data sets accumulated at the Soudan Underground Laboratory in Minnesota. Results from the original analysis of these data were published in 2009; two events were observed in the signal region with an expected leakage of 0.9 events. Further investigation revealed an issue with the ionization-pulse reconstruction algorithm leading to a software upgrade and a subsequent reanalysis of the data. As part of the reanalysis, I performed an advanced discrimination technique to better distinguish (potential) signal events from backgrounds using a 5-dimensional chi-square method. This data-analysis technique combines the event information recorded for each WIMP-search event to derive a background-discrimination parameter capable of reducing the expected background to less than one event, while maintaining high efficiency for signal events. Furthermore, optimizing the cut positions of this 5-dimensional chi-square parameter for the 14 viable germanium detectors yields an improved expected sensitivity to WIMP interactions relative to previous CDMS results. This dissertation describes my improved (and optimized) discrimination technique and the results obtained from a blind application to the reanalyzed CDMS II WIMP-search data. This analysis achieved the best expected sensitivity of the three techniques developed for the reanalysis and so was chosen as the primary timing analysis whose limit will be quoted in a on-going publication paper which is currently in preparation. For this analysis, a total raw exposure of 612.17 kg-days are analyzed for this work. No candidate events was observed, and a corresponding upper limit on the WIMP-nucleon scattering cross section as a function of WIMP mass is defined. These data set a 90% upper limit on spin-independent WIMP-nucleon elastic-scattering cross section of 3.19 × 10-44 cm2 for a WIMP mass of 60 GeV c 2. Combining this result with all previous CDMS II data gives an upper limit of 1.96 ×10-44 cm2 for a WIMP of mass 60 GeV/c2 (a factor of 2 better than the original analysis). At the moment this analysis is being written, the WIMP-search results obtained with the reanalyzed CDMS II data occupies the second most stringent limits on WIMP-nucleon scattering, after XENON100, excluding previously unexplored parameter space. Interesting parameter space is excluded for WIMP-nucleon cross section as function of WIMP masse under standard assumptions, the parameter space favored by interpretations of other experiments's data as low-mass WIMP signals due to an excess of low energy events and annual modulation is partially excluded for DAMA/LIBRA and CoGeNT.

Task I: Dark Matter Search Experiments with Cryogenic Detectors: CDMS-I and CDMS-II Task II: Experimental Study of Neutrino Properties: EXO and KamLAND

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cabrera, Blas; Gratta, Giorgio

2013-08-30

Dark Matter Search - During the period of performance, our group continued the search for dark matter in the form of weakly interacting massive particles or WIMPs. As a key member of the CDMS (Cryogenic Dark Matter Search) collaboration, we completed the CDMS II experiment which led the field in sensitivity for more than five years. We fabricated all detectors, and participated in detector testing and verification. In addition, we participated in the construction and operation of the facility at the Soudan Underground Laboratory and played key roles in the data acquisition and analysis. Towards the end of the performancemore » period, we began operating the SuperCDMS Soudan experiment, which consists of 15 advanced Ge (9 kg) detectors. The advanced detector design called iZIP grew out of our earlier DOE Particle Detector R&D program which demonstrated the rejection of surface electrons to levels where they are no longer the dominant source of background. Our group invented this advanced design and these larger detectors were fabricated on the Stanford campus in collaboration with the SLAC CDMS group and the Santa Clara University group. The sensitivity reach is expected to be up to 5 times better than CDMS II after two years of operation. We will check the new limits on WIMPs set by XENON100, and we expect improved sensitivity for light mass WIMPs beyond that of any other existing experiment. Our group includes the Spokesperson for SuperCDMS and continues to make important contributions to improvements in the detector technology which are enabling the very low trigger thresholds used to explore the low mass WIMP region. We are making detailed measurements of the charge transport and trapping within Ge crystals, measuring the diffusive trapping distance of the quasiparticle excitations within the Al phonon collector fins on the detector surface, and we are contributing to the development of much improved detector Monte Carlos which are essential to guide the detector design and optimize the analysis. Neutrino Physics – In the period of performance the neutrino group successfully completed the construction of EXO-200 and commissioned the detector. Science data taking started on Jun 1, 2011. With the discovery of the 2-neutrino double-beta decay in 136-Xe and the first measurement of the 0-neutrino mode resulting in the most stringent limit of Majorana masses, our group continues to be a leading innovator in the field of neutrino physics which is central to DOE-HEP Intensity Frontier program. The phenomenon of neutrino oscillations, in part elucidated by our earlier efforts with the Palo Verde and KamLAND experiments, provides the crucial information that neutrino masses are non-zero and, yet, it contains no information on the value of the neutrino mass scale. In recent times our group has therefore shifted its focus to a high sensitivity 0-neutrino double beta decay program, EXO. The 0-neutrino double beta decay provides the best chance of extending the sensitivity to the neutrino mass scale below 10 meV but, maybe more importantly, it tests the nature of the neutrino wave function, providing the most sensitive probe for Majorana particles and lepton number violation. The EXO program, formulated by our group several years ago, plans to use up to tonnes of the isotope 136-Xe to study the 0-neutrino double beta decay mode. The EXO-200 detector is the first step in this program and it represents the only large US-led and based experiment taking data. The EXO-200 isotope enrichment program broke new grounds for the enterprise of double beta decay. The detector design and material selection program paid off, resulting in a background that is among the very best in the field. The “first light" of EXO-200 was very exciting with the discovery -in the first month of data- of the rarest 2-neutrino double beta decay mode ever observed. The lower limit on the 0-neutrino double beta decay half-life, published in Phys. Rev. Lett. and based on the first 120 days of data is the second best but, when translated into a Majorana mass scale, it is one of the most stringent constraint we have on neutrino masses. Indeed, such a limit was the first result to contradict a claim of discovery in 76-Ge for most nuclear matrix elements calculations. As we continue data taking and plan some modest upgrades to EXO-200 our group is also very active in the design of nEXO, a 5 tonne detector based on the technology demonstrated by EXO-200. Over the years we have made it a tradition to explore the frontier and not to be shy about looking in new directions and re-inventing ourselves to best take advantage of the precious few opportunities provided by Nature. We have also cultivated a number of young people at all levels and, by now, many of the undergraduates, graduate students and postdocs educated by this group have leading positions in academia and industry around the world.« less

VizieR Online Data Catalog: Sub-millimeter spectra of 2-hydroxyacetonitrile (Margules+, 2017)

NASA Astrophysics Data System (ADS)

Margules, L.; McGuire, B. A.; Senent, M. L.; Motiyenko, R. A.; Remijan, A.; Guillemin, J. C.

2017-02-01

Measured frequencies and residuals from the global fit of the submillimeter-wave data for 2-hydroxyacetonitrile and files used for SPFIT. Detailled explanations on SPFIT could be found at https://www.astro.uni-koeln.de/cdms/pickett (4 data files).

Cognitive Diagnostic Analysis Using Hierarchically Structured Skills

ERIC Educational Resources Information Center

Su, Yu-Lan

2013-01-01

This dissertation proposes two modified cognitive diagnostic models (CDMs), the deterministic, inputs, noisy, "and" gate with hierarchy (DINA-H) model and the deterministic, inputs, noisy, "or" gate with hierarchy (DINO-H) model. Both models incorporate the hierarchical structures of the cognitive skills in the model estimation…

Supersymmetric model for dark matter and baryogenesis motivated by the recent CDMS result.

PubMed

Allahverdi, Rouzbeh; Dutta, Bhaskar; Mohapatra, Rabindra N; Sinha, Kuver

2013-08-02

We discuss a supersymmetric model for cogenesis of dark and baryonic matter where the dark matter (DM) has mass in the 8-10 GeV range as indicated by several direct detection searches, including most recently the CDMS experiment with the desired cross section. The DM candidate is a real scalar field. Two key distinguishing features of the model are the following: (i) in contrast with the conventional weakly interacting massive particle dark matter scenarios where thermal freeze-out is responsible for the observed relic density, our model uses nonthermal production of dark matter after reheating of the Universe caused by moduli decay at temperatures below the QCD phase transition, a feature which alleviates the relic overabundance problem caused by small annihilation cross section of light DM particles and (ii) baryogenesis occurs also at similar low temperatures from the decay of TeV scale mediator particles arising from moduli decay. A possible test of this model is the existence of colored particles with TeV masses accessible at the LHC.

Ab Initio Classical Dynamics Simulations of CO_2 Line-Mixing Effects in Infrared Bands

NASA Astrophysics Data System (ADS)

Lamouroux, Julien; Hartmann, Jean-Michel; Tran, Ha; Snels, Marcel; Stefani, Stefania; Piccioni, Giuseppe

2013-06-01

Ab initio calculations of line-mixing effects in CO_2 infrared bands are presented and compared with experiments. The predictions were carried using requantized Classical Dynamics Molecular Simulations (rCDMS) based on an approach previously developed and successfully tested for CO_2 isolated line shapes. Using classical dynamics equations, the force and torque applied to each molecule by the surrounding molecules (described by an ab initio intermolecular potential) are computed at each time step. This enables, using a requantization procedure, to predict dipole and isotropic polarizability auto-correlation functions whose Fourier-Laplace transforms yield the spectra. The quality of the rCDMS calculations is demonstrated by comparisons with measured spectra in the spectral regions of the 3ν_3 and 2ν_1+2ν_2+ν_3 Infrared bands. J.-M. Hartmann, H. Tran, N. H. Ngo, et al., Phys. Rev. Lett. A {87} (2013), 013403. H. Tran, C. Boulet, M. Snels, S. Stefani, J. Quant. Spectrosc. Radiat. Transfer {112} (2011), 925-936.

VizieR Online Data Catalog: 15NH2 amidogen radical rotational spectrum (M

NASA Astrophysics Data System (ADS)

Margules, L.; Martin-Drumel, M. A.; Pirali, O.; Bailleux, S.; Wlodarczak, G.; Roy, P.; Roueff, E.; Gerin, M.

2016-04-01

Measured frequencies and residuals from the global fit of the Infrared, and submillimeter-wave data for 15NH2 and files used for SPFIT. Detailled explanations on SPFIT could be found at https://www.astro.uni-koeln.de/cdms/pickett (4 data files).

Cognitive Diagnostic Attribute-Level Discrimination Indices

ERIC Educational Resources Information Center

Henson, Robert; Roussos, Louis; Douglas, Jeff; He, Xuming

2008-01-01

Cognitive diagnostic models (CDMs) model the probability of correctly answering an item as a function of an examinee's attribute mastery pattern. Because estimation of the mastery pattern involves more than a continuous measure of ability, reliability concepts introduced by classical test theory and item response theory do not apply. The cognitive…

Variable-Length Computerized Adaptive Testing Based on Cognitive Diagnosis Models

ERIC Educational Resources Information Center

Hsu, Chia-Ling; Wang, Wen-Chung; Chen, Shu-Ying

2013-01-01

Interest in developing computerized adaptive testing (CAT) under cognitive diagnosis models (CDMs) has increased recently. CAT algorithms that use a fixed-length termination rule frequently lead to different degrees of measurement precision for different examinees. Fixed precision, in which the examinees receive the same degree of measurement…

The Effect of Multimedia Replacing Text in Resident Clinical Decision-Making Assessment

ERIC Educational Resources Information Center

Chang, Todd P.; Schrager, Sheree M.; Rake, Alyssa J.; Chan, Michael W.; Pham, Phung K.; Christman, Grant

2017-01-01

Multimedia in assessing clinical decision-making skills (CDMS) has been poorly studied, particularly in comparison to traditional text-based assessments. The literature suggests multimedia is more difficult for trainees. We hypothesize that pediatric residents score lower in diagnostic skill when clinical vignettes use multimedia rather than text…

Training Detractors in FORSCOM Divisions and How They Are Handled

DTIC Science & Technology

1980-05-01

mandatory training on conducting effective combat training, and explored four resource areas No. DD JAN 1473 EDITION OF I NOV 65 IS OBSOLETE...INSTITUTIONAL RSCH I USA AIR DEFENSE SCHOOL AITN: AISA -CD-MS 1 USAA|)S-LIBRARY-DOCUMENIS I USA AIR DEFENSE BOAR) ATIN: FILES REPOSITORY I USA sERGEANTS

Parameter Invariance and Skill Attribute Continuity in the DINA Model

ERIC Educational Resources Information Center

Bolt, Daniel M.; Kim, Jee-Seon

2018-01-01

Cognitive diagnosis models (CDMs) typically assume skill attributes with discrete (often binary) levels of skill mastery, making the existence of skill continuity an anticipated form of model misspecification. In this article, misspecification due to skill continuity is argued to be of particular concern for several CDM applications due to the…

Retrofitting Non-Cognitive-Diagnostic Reading Assessment under the Generalized DINA Model Framework

ERIC Educational Resources Information Center

Chen, Huilin; Chen, Jinsong

2016-01-01

Cognitive diagnosis models (CDMs) are psychometric models developed mainly to assess examinees' specific strengths and weaknesses in a set of skills or attributes within a domain. By adopting the Generalized-DINA model framework, the recently developed general modeling framework, we attempted to retrofit the PISA reading assessments, a…

Charge Transport Phenomena in Detectors of the Cryogenic Dark Matter Search

NASA Astrophysics Data System (ADS)

Sundqvist, Kyle

2008-03-01

The Cryogenic Dark Matter Search (CDMS) seeks to detect putative weakly-interacting massive particles (WIMPS), which could explain the dark matter problem in cosmology and particle physics. By simultaneously measuring the number of charge carriers and the energy in athermal phonons created by particle interactions in intrinsic Ge and Si crystals at a temperature of 40 mK, a signature response for each event is produced. This response, combined with phonon pulse-shape information, allows CDMS to actively discriminate candidate WIMP interactions with nuclei apart from electromagnetic radioactive background which interacts with electrons. The challenges associated with these techniques are unique. Carrier drift-fields are maintained at only a few V/cm, else drift-emitted Luke-Neganov phonons would dominate the phonons of the original interaction. Under such conditions, carrier scattering is dominated by zero-point fluctuations of the lattice ions. It has been an open question how well the 8 Kelvin data prominent in the literature depicts this case. We compare the simulated transport properties of electrons and holes in <100> Ge at 40 mK and at 8 K, and apply this understanding to our detectors.

Exothermic dark matter

DOE Office of Scientific and Technical Information (OSTI.GOV)

Graham, Peter W.; Saraswat, Prashant; Harnik, Roni

2010-09-15

We propose a novel mechanism for dark matter to explain the observed annual modulation signal at DAMA/LIBRA which avoids existing constraints from every other dark matter direct detection experiment including CRESST, CDMS, and XENON10. The dark matter consists of at least two light states with mass {approx}few GeV and splittings {approx}5 keV. It is natural for the heavier states to be cosmologically long-lived and to make up an O(1) fraction of the dark matter. Direct detection rates are dominated by the exothermic reactions in which an excited dark matter state downscatters off of a nucleus, becoming a lower energy state.more » In contrast to (endothermic) inelastic dark matter, the most sensitive experiments for exothermic dark matter are those with light nuclei and low threshold energies. Interestingly, this model can also naturally account for the observed low-energy events at CoGeNT. The only significant constraint on the model arises from the DAMA/LIBRA unmodulated spectrum but it can be tested in the near future by a low-threshold analysis of CDMS-Si and possibly other experiments including CRESST, COUPP, and XENON100.« less

Anti-myelin antibodies predict the clinical outcome after a first episode suggestive of MS.

PubMed

Tomassini, V; De Giglio, L; Reindl, M; Russo, P; Pestalozza, I; Pantano, P; Berger, T; Pozzilli, C

2007-11-01

The aim of this study was to test the contribution of anti-myelin antibodies in predicting conversion from clinically isolated syndrome (CIS) to multiple sclerosis (MS) when considering either Poser's or McDonald's diagnostic criteria. Fifty-one patients with CIS and abnormal brain MRI were imaged monthly for six months and then at 12, 18, 24, 36 months. At baseline serum samples testing antibodies against myelin oligodendrocyte glycoprotein (anti-MOG) and myelin basic protein (anti-MBP) were collected. During the 36-month follow-up, 26 (51%) patients developed a relapse thus becoming clinically definite MS (CDMS) according to Poser's criteria; 46 (90.2%) patients converted to MS according to McDonald's criteria. Out of 51 patients, 28 (54.9%) had either double or single positivity for anti-myelin antibodies. Antibody status significantly predicted MS according to Poser's criteria (P=0.004), but did not according to the McDonald's criteria. When compared to antibody negative patients, the risk of developing a relapse was 8.9 (95% CI: 2.7-29.8; P<0.001) for anti-MBP positive (anti-MBP+) patients and 1.5 (95% CI: 0.4-5.4; P=0.564) for those anti-MOG positive (anti-MOG+); double positive patients (ie, anti-MBP+/anti-MOG+) had a risk of relapse's occurrence equal to 3.4 (95% CI: 1.1-10.2; P=0.031). Also, the antibody status predicted the median time span from CIS to CDMS, that was of 36 months in the anti-MOG-/anti-MBP- group, 33 months in the anti-MOG+/anti-MBP- group, 24 months in the anti-MOG+/anti-MBP+ group and 12 months in the anti-MOG-/anti-MBP+ patients (P=0.003 by ANOVA). Our data support the prognostic value of anti-myelin antibodies in CIS patients at risk of CDMS, with positive patients showing shorter time interval to relapse occurrence than negative patients.

The 11-year long-term follow-up study from the randomized BENEFIT CIS trial

PubMed Central

Edan, Gilles; Freedman, Mark S.; Montalbán, Xavier; Hartung, Hans-Peter; Hemmer, Bernhard; Fox, Edward J.; Barkhof, Frederik; Schippling, Sven; Schulze, Andrea; Pleimes, Dirk; Pohl, Christoph; Sandbrink, Rupert; Suarez, Gustavo; Wicklein, Eva-Maria

2016-01-01

Objective: To assess outcomes for patients treated with interferon beta-1b immediately after clinically isolated syndrome (CIS) or after a short delay. Methods: Participants in BENEFIT (Betaferon/Betaseron in Newly Emerging MS for Initial Treatment) were randomly assigned to receive interferon beta-1b (early treatment) or placebo (delayed treatment). After conversion to clinically definite multiple sclerosis (CDMS) or 2 years, patients on placebo could switch to interferon beta-1b or another treatment. Eleven years after randomization, patients were reassessed. Results: Two hundred seventy-eight (59.4%) of the original 468 patients (71.3% of those eligible at participating sites) were enrolled (early: 167 [57.2%]; delayed: 111 [63.1%]). After 11 years, risk of CDMS remained lower in the early-treatment arm compared with the delayed-treatment arm (p = 0.0012), with longer time to first relapse (median [Q1, Q3] days: 1,888 [540, not reached] vs 931 [253, 3,296]; p = 0.0005) and lower overall annualized relapse rate (0.21 vs 0.26; p = 0.0018). Only 25 patients (5.9%, overall; early, 4.5%; delayed, 8.3%) converted to secondary progressive multiple sclerosis. Expanded Disability Status Scale scores remained low and stable, with no difference between treatment arms (median [Q1, Q3]: 2.0 [1.0, 3.0]). The early-treatment group had better Paced Auditory Serial Addition Task–3 total scores (p = 0.0070). Employment rates remained high, and health resource utilization tended to be low in both groups. MRI metrics did not differ between groups. Conclusions: Although the delay in treatment was relatively short, several clinical outcomes favored earlier treatment. Along with low rates of disability and disease progression in both groups, this supports the value of treatment at CIS. ClinicalTrials.gov identifier: NCT01795872. Classification of evidence: This study provides Class IV evidence that early compared to delayed treatment prolongs time to CDMS in CIS after 11 years. PMID:27511182

Investigation of Missing Responses in Implementation of Cognitive Diagnostic Models

ERIC Educational Resources Information Center

Dai, Shenghai

2017-01-01

This dissertation is aimed at investigating the impact of missing data and evaluating the performance of five selected methods for handling missing responses in the implementation of Cognitive Diagnostic Models (CDMs). The five methods are: a) treating missing data as incorrect (IN), b) person mean imputation (PM), c) two-way imputation (TW), d)…

Validation of a Cognitive Diagnostic Model across Multiple Forms of a Reading Comprehension Assessment

ERIC Educational Resources Information Center

Clark, Amy K.

2013-01-01

The present study sought to fit a cognitive diagnostic model (CDM) across multiple forms of a passage-based reading comprehension assessment using the attribute hierarchy method. Previous research on CDMs for reading comprehension assessments served as a basis for the attributes in the hierarchy. The two attribute hierarchies were fit to data from…

Case Report Form Reporter: A Key Component for the Integration of Electronic Medical Records and the Electronic Data Capture System.

PubMed

Matsumura, Yasushi; Hattori, Atsushi; Manabe, Shiro; Takahashi, Daiyo; Yamamoto, Yuichiro; Murata, Taizo; Nakagawa, Akito; Mihara, Naoki; Takeda, Toshihiro

2017-01-01

To improve the efficiency of clinical research, we developed a system to integrate electronic medical records (EMRs) and the electronic data capture system (EDC). EDC is divided into case report form (CRF) reporter and CDMS with CRF receiver with data communication using the operational data model (ODM). The CRF reporter is incorporated into the EMR to share data witth the EMR. In the data transcription type, doctors enter data using a progress note template, which are transmitted to the reporter template. It then generates the ODM. In the direct record type, reporter templates open from the progress note and generate narrative text to make record in the progress note. The configuration files for a study are delivered from the contents server to minimize the setup. This system has been used for 15 clinical studies including 3 clinical trials. This system can save labor and financial costs in clinical research.

Commensurate 4a0-period charge density modulations throughout the Bi2Sr2CaCu2O8+x pseudogap regime

PubMed Central

Mesaros, Andrej; Fujita, Kazuhiro; Edkins, Stephen D.; Hamidian, Mohammad H.; Eisaki, Hiroshi; Uchida, Shin-ichi; Davis, J. C. Séamus; Lawler, Michael J.; Kim, Eun-Ah

2016-01-01

Theories based upon strong real space (r-space) electron–electron interactions have long predicted that unidirectional charge density modulations (CDMs) with four-unit-cell (4a0) periodicity should occur in the hole-doped cuprate Mott insulator (MI). Experimentally, however, increasing the hole density p is reported to cause the conventionally defined wavevector QA of the CDM to evolve continuously as if driven primarily by momentum-space (k-space) effects. Here we introduce phase-resolved electronic structure visualization for determination of the cuprate CDM wavevector. Remarkably, this technique reveals a virtually doping-independent locking of the local CDM wavevector at |Q0|=2π/4a0 throughout the underdoped phase diagram of the canonical cuprate Bi2Sr2CaCu2O8. These observations have significant fundamental consequences because they are orthogonal to a k-space (Fermi-surface)–based picture of the cuprate CDMs but are consistent with strong-coupling r-space–based theories. Our findings imply that it is the latter that provides the intrinsic organizational principle for the cuprate CDM state. PMID:27791157

Commensurate 4 a 0 -period charge density modulations throughout the Bi 2 Sr 2 CaCu 2 O 8+x pseudogap regime

DOE PAGES

Mesaros, Andrej; Fujita, Kazuhiro; Edkins, Stephen D.; ...

2016-10-20

Theories based upon strong real space (r-space) electron–electron interactions have long predicted that unidirectional charge density modulations (CDMs) with four-unit-cell (4 a0) periodicity should occur in the hole-doped cuprate Mott insulator (MI). But, increasing the hole density p is reported to cause the conventionally defined wavevector Q A of the CDM to evolve continuously as if driven primarily by momentum-space (k-space) effects. We introduce phase-resolved electronic structure visualization for determination of the cuprate CDM wavevector. Remarkably, this technique reveals a virtually doping-independent locking of the local CDM wavevector at |Q 0|=2π/4 a0 throughout the underdoped phase diagram of the canonicalmore » cuprate Bi 2Sr 2CaCu 2O 8. Our observations have significant fundamental consequences because they are orthogonal to a k-space (Fermi-surface)–based picture of the cuprate CDMs but are consistent with strong-coupling r-space–based theories. Our findings imply that it is the latter that provides the intrinsic organizational principle for the cuprate CDM state.« less

Statistical Analysis of Deflation in Covariance and Resultant Pc Values for AQUA, AURA and TERRA

NASA Technical Reports Server (NTRS)

Hasan, Syed O.

2016-01-01

This presentation will display statistical analysis performed for raw conjunction CDMs received for the EOS Aqua, Aura and Terra satellites within the period of February 2015 through July 2016. The analysis performed indicates a discernable deflation in covariance calculated at the JSpOC after the utilization of the dynamic drag consider parameter was implemented operationally in May 2015. As a result, the overall diminution in the conjunction plane intersection of the primary and secondary objects appears to be leading to reduced probability of collision (Pc) values for these conjunction events. This presentation also displays evidence for this theory with analysis of Pc trending plots using data calculated by the SpaceNav CRMS system.

Spacelab payload accommodation handbook. Appendix B: Structure interface definition module

NASA Technical Reports Server (NTRS)

1978-01-01

The mechanical interfaces between Spacelab and its payload are defined. The envelopes available for mounting payload hardware are specified together with the standard structural attachment interfaces. Overall load capabilities and the local load capabilities for individual attachment interfaces are defined for the standard mounting locations. The mechanical environment is defined and the mechanical interfaces between the payload and the EPDS, CDMS and ECS are included.

On the Analysis of Fraction Subtraction Data: The DINA Model, Classification, Latent Class Sizes, and the Q-Matrix

ERIC Educational Resources Information Center

DeCarlo, Lawrence T.

2011-01-01

Cognitive diagnostic models (CDMs) attempt to uncover latent skills or attributes that examinees must possess in order to answer test items correctly. The DINA (deterministic input, noisy "and") model is a popular CDM that has been widely used. It is shown here that a logistic version of the model can easily be fit with standard software for…

SuperCDMS - Home

Science.gov Websites

radiation and therefore it cannot be seen, which has earned it the title Dark Matter. Dark matter rest (approximately three quarters) of all the matter and energy in the universe is referred to as dark energy. Dark matter is most commonly hypothesized to be made up of exotic particles such as WIMPS (Weakly

Fermilab Today | Results for the Frontiers | 2015

Science.gov Websites

: Subatomic gryphons Sept. 24, 2015 CDF: More than expected Sept. 22, 2015 CDMS: The lightness of dark matter CDF: Happy hunting grounds April 3, 2015 PICO: Seeing dark matter March 27, 2015 CMS: Rule of three the weak and the charmed July 24, 2015 DES: Cosmic shear cosmology with the Dark Energy Survey July 17

A Low-threshold Analysis of Data from the Cryogenic Dark Matter Search Experiment

NASA Astrophysics Data System (ADS)

Bunker, Raymond A., III

Although dark matter appears to constitute over 80% of the matter in the Universe, its composition is a mystery. Astrophysical observations suggest that the luminous portions of the Galaxy are embedded in a halo of darkmatter particles. Weakly Interacting Massive Particles (WIMPs) are the most studied class of dark-matter candidates and arise naturally within the context of many weak-scale supersymmetric theories. Direct-detection experiments like the Cryogenic Dark Matter Search (CDMS) strive to discern the kinetic energy of recoiling nuclei resulting from WIMP interactions with terrestrial matter. This is a considerable challenge in which the low (expected) rate of WIMP interactions must be distinguished from an overwhelming rate due to known types of radiation. An incontrovertible positive detection has remained elusive. However, a few experiments have recorded data that appear consistent with a low-mass WIMP. This thesis describes an attempt to probe the favored parameter space. To increase sensitivity to low-mass WIMPs, a low-threshold technique with improved sensitivity to small energy depositions is applied to CDMS shallow-site data. Four germanium and two silicon detectors were operated between December 2001 and June 2002, yielding 118 days of exposure. By sacrificing some of the CDMS detectors' ability to discriminate signal from background, energy thresholds of ˜1 and ˜2 keV were achieved for three of the germanium and both silicon detectors, respectively. A large number of WIMP candidate events are observed, most of which can be accounted for by misidentification of background sources. No conclusive evidence for a low-mass WIMP signal is found. The observed event rates are used to set upper limits on the WIMPnucleon scattering cross section as a function of WIMP mass. Interesting parameter space is excluded for WIMPs with masses below ˜9GeV/c 2. Under standard assumptions, the parameter space favored by interpretations of other experiments' data as low-mass WIMP signals is partially excluded, and new parameter space is excluded for WIMP masses between 3 and 4GeV/ c2.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Welliver, Bradford

Recent cosmological evidence suggests most of the mass of the universe takes the form of a type of particle that we have not been able to directly detect. Nearly 80 years that have elapsed since the rst hints of this dark matter started to appear from astronomers without any direct detection. The high precision era of cosmology and unifying models of particle physics developed in the 20 th century have presented us with an exciting mystery at the intersection of these two elds that needs to be solved. SuperCDMS Soudan operates specialized germanium detectors (iZIPs) that are cooled to milliKelvinmore » temperatures deep underground in the Soudan Underground Laboratory with the hope of detecting a rare collision between dark matter and a nucleus. A search for low-mass dark matter comes with multiple unique challenges since the background discrimination abilities of these detectors becomes less powerful at the low energies needed to probe low-mass dark matter since the signal to noise ratio deteriorates. Using a sophisticated background model via a pulse rescaling technique, SuperCDMS Soudan was able to produce a world leading exclusion limit on low-mass dark matter. Effort is to extend the analysis to higher masses require long running times during which many aspects of the detectors or the environment can change. Additional challenges are offered by the powerful background discrimination ability of the iZIP. The background distributions are well separated from the signal region, meaning most of the leakage arises from low-probability tails of the background distributions. In the absence of an enormous dataset, extrapolations from the bulk of the distribution are required. While attempting to obtain a model of gamma induced electron-recoils leaking into the signal region of the detector from high radius a curious asymmetry between the sides of the detectors was discovered potentially indicating an electronics or detector design problem. This thesis describes the physics behind SuperCDMS Soudan, the numerous tasks involved in a low-mass search and the rst iZIP array science results with these new detectors, as well as the developments towards a high-mass search result.« less

In the Face of Cybersecurity: How the Common Information Model Can Be Used

DOE Office of Scientific and Technical Information (OSTI.GOV)

Skare, Paul; Falk, Herbert; Rice, Mark

2016-01-01

Efforts are underway to combine smart grid information, devices, networking, and emergency response information to create messages that are not dependent on specific standards development organizations (SDOs). This supports a future-proof approach of allowing changes in the canonical data models (CDMs) going forward without having to perform forklift replacements of solutions that use the messages. This also allows end users (electric utilities) to upgrade individual components of a larger system while keeping the message payload definitions intact. The goal is to enable public and private information sharing securely in a standards-based approach that can be integrated into existing operations. Wemore » provide an example architecture that could benefit from this multi-SDO, secure message approach. This article also describes how to improve message security« less

Simulated Milky Way analogues: implications for dark matter direct searches

NASA Astrophysics Data System (ADS)

Bozorgnia, Nassim; Calore, Francesca; Schaller, Matthieu; Lovell, Mark; Bertone, Gianfranco; Frenk, Carlos S.; Crain, Robert A.; Navarro, Julio F.; Schaye, Joop; Theuns, Tom

2016-05-01

We study the implications of galaxy formation on dark matter direct detection using high resolution hydrodynamic simulations of Milky Way-like galaxies simulated within the EAGLE and APOSTLE projects. We identify Milky Way analogues that satisfy observational constraints on the Milky Way rotation curve and total stellar mass. We then extract the dark matter density and velocity distribution in the Solar neighbourhood for this set of Milky Way analogues, and use them to analyse the results of current direct detection experiments. For most Milky Way analogues, the event rates in direct detection experiments obtained from the best fit Maxwellian distribution (with peak speed of 223-289 km/s) are similar to those obtained directly from the simulations. As a consequence, the allowed regions and exclusion limits set by direct detection experiments in the dark matter mass and spin-independent cross section plane shift by a few GeV compared to the Standard Halo Model, at low dark matter masses. For each dark matter mass, the halo-to-halo variation of the local dark matter density results in an overall shift of the allowed regions and exclusion limits for the cross section. However, the compatibility of the possible hints for a dark matter signal from DAMA and CDMS-Si and null results from LUX and SuperCDMS is not improved.

Assessing compatibility of direct detection data: halo-independent global likelihood analyses

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gelmini, Graciela B.; Huh, Ji-Haeng; Witte, Samuel J.

2016-10-18

We present two different halo-independent methods to assess the compatibility of several direct dark matter detection data sets for a given dark matter model using a global likelihood consisting of at least one extended likelihood and an arbitrary number of Gaussian or Poisson likelihoods. In the first method we find the global best fit halo function (we prove that it is a unique piecewise constant function with a number of down steps smaller than or equal to a maximum number that we compute) and construct a two-sided pointwise confidence band at any desired confidence level, which can then be comparedmore » with those derived from the extended likelihood alone to assess the joint compatibility of the data. In the second method we define a “constrained parameter goodness-of-fit” test statistic, whose p-value we then use to define a “plausibility region” (e.g. where p≥10%). For any halo function not entirely contained within the plausibility region, the level of compatibility of the data is very low (e.g. p<10%). We illustrate these methods by applying them to CDMS-II-Si and SuperCDMS data, assuming dark matter particles with elastic spin-independent isospin-conserving interactions or exothermic spin-independent isospin-violating interactions.« less

Soudan Low Background Counting Facility (SOLO)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Attisha, Michael; Viveiros, Luiz de; Gaitksell, Richard

2005-09-08

The Soudan Low Background Counting Facility (SOLO) has been in operation at the Soudan Mine, MN since March 2003. In the past two years, we have gamma-screened samples for the Majorana, CDMS and XENON experiments. With individual sample exposure times of up to two weeks we have measured sample contamination down to the 0.1 ppb level for 238U / 232Th, and down to the 0.25 ppm level for 40K.

Increased Concentrations of Glutamate and Glutamine in Normal-Appearing White Matter of Patients with Multiple Sclerosis and Normal MR Imaging Brain Scans

PubMed Central

Tisell, Anders; Leinhard, Olof Dahlqvist; Warntjes, Jan Bertus Marcel; Aalto, Anne; Smedby, Örjan; Landtblom, Anne-Marie; Lundberg, Peter

2013-01-01

In Multiple Sclerosis (MS) the relationship between disease process in normal-appearing white matter (NAWM) and the development of white matter lesions is not well understood. In this study we used single voxel proton ‘Quantitative Magnetic Resonance Spectroscopy’ (qMRS) to characterize the NAWM and thalamus both in atypical ‘Clinically Definite MS’ (CDMS) patients, MRIneg (N = 15) with very few lesions (two or fewer lesions), and in typical CDMS patients, MRIpos (N = 20) with lesions, in comparison with healthy control subjects (N = 20). In addition, the metabolite concentrations were also correlated with extent of brain atrophy measured using Brain Parenchymal Fraction (BPF) and severity of the disease measured using ‘Multiple Sclerosis Severity Score’ (MSSS). Elevated concentrations of glutamate and glutamine (Glx) were observed in both MS groups (MRIneg 8.12 mM, p<0.001 and MRIpos 7.96 mM p<0.001) compared to controls, 6.76 mM. Linear regressions of Glx and total creatine (tCr) with MSSS were 0.16±0.06 mM/MSSS (p = 0.02) for Glx and 0.06±0.03 mM/MSSS (p = 0.04) for tCr, respectively. Moreover, linear regressions of tCr and myo-Inositol (mIns) with BPF were −6.22±1.63 mM/BPF (p<0.001) for tCr and −7.71±2.43 mM/BPF (p = 0.003) for mIns. Furthermore, the MRIpos patients had lower N-acetylaspartate and N-acetylaspartate-glutamate (tNA) and elevated mIns concentrations in NAWM compared to both controls (tNA: p = 0.04 mIns p<0.001) and MRIneg (tNA: p = 0.03 , mIns: p = 0.002). The results suggest that Glx may be an important marker for pathology in non-lesional white matter in MS. Moreover, Glx is related to the severity of MS independent of number of lesions in the patient. In contrast, increased glial density indicated by increased mIns and decreased neuronal density indicated by the decreased tNA, were only observed in NAWM of typical CDMS patients with white matter lesions. PMID:23613944

Final Technical Report for ARRA Funding

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rusack, Roger; Mans, Jeremiah; Poling, Ronald

Final technical report of the University of Minnesota experimental high energy physics group for ARRA support. The Cryogenic Dark Matter Experiment (CDMS) used the funds received to construct a new passive shield to protect a high-purity germanium detector located in the Soudan mine in Northern Minnesota from cosmic rays. The BESIII and the CMS groups purchased computing hardware to assemble computer farms for data analysis and to generate large volumes of simulated data for comparison with the data collected.

Simulated Milky Way analogues: implications for dark matter direct searches

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bozorgnia, Nassim; Calore, Francesca; Lovell, Mark

2016-05-01

We study the implications of galaxy formation on dark matter direct detection using high resolution hydrodynamic simulations of Milky Way-like galaxies simulated within the EAGLE and APOSTLE projects. We identify Milky Way analogues that satisfy observational constraints on the Milky Way rotation curve and total stellar mass. We then extract the dark matter density and velocity distribution in the Solar neighbourhood for this set of Milky Way analogues, and use them to analyse the results of current direct detection experiments. For most Milky Way analogues, the event rates in direct detection experiments obtained from the best fit Maxwellian distribution (withmore » peak speed of 223–289 km/s) are similar to those obtained directly from the simulations. As a consequence, the allowed regions and exclusion limits set by direct detection experiments in the dark matter mass and spin-independent cross section plane shift by a few GeV compared to the Standard Halo Model, at low dark matter masses. For each dark matter mass, the halo-to-halo variation of the local dark matter density results in an overall shift of the allowed regions and exclusion limits for the cross section. However, the compatibility of the possible hints for a dark matter signal from DAMA and CDMS-Si and null results from LUX and SuperCDMS is not improved.« less

Searching for dark absorption with direct detection experiments

DOE PAGES

Bloch, Itay M.; Essig, Rouven; Tobioka, Kohsaku; ...

2017-06-16

We consider the absorption by bound electrons of dark matter in the form of dark photons and axion-like particles, as well as of dark photons from the Sun, in current and next-generation direct detection experiments. Experiments sensitive to electron recoils can detect such particles with masses between a few eV to more than 10 keV. For dark photon dark matter, we update a previous bound based on XENON10 data and derive new bounds based on data from XENON100 and CDMSlite. We find these experiments to disfavor previously allowed parameter space. Moreover, we derive sensitivity projections for SuperCDMS at SNOLAB formore » silicon and germanium targets, as well as for various possible experiments with scintillating targets (cesium iodide, sodium iodide, and gallium arsenide). The projected sensitivity can probe large new regions of parameter space. For axion-like particles, the same current direction detection data improves on previously known direct-detection constraints but does not bound new parameter space beyond known stellar cooling bounds. However, projected sensitivities of the upcoming SuperCDMS SNOLAB using germanium can go beyond these and even probe parameter space consistent with possible hints from the white dwarf luminosity function. We find similar results for dark photons from the sun. For all cases, direct-detection experiments can have unprecedented sensitivity to dark-sector particles.« less

New class of biological detectors for WIMPs

NASA Astrophysics Data System (ADS)

Drukier, A. K.; Cantor, Ch.; Chonofsky, M.; Church, G. M.; Fagaly, R. L.; Freese, K.; Lopez, A.; Sano, T.; Savage, C.; Wong, W. P.

2014-07-01

Weakly Interacting Massive Particles (WIMPs) may constitute a large fraction of the matter in the Universe. There are excess events in the data of DAMA/LIBRA, CoGeNT, CRESST-II, and recently CDMS-Si, which could be consistent with WIMP masses of approximately 10 GeV/c2. However, for MDM > 10 GeV/c2 null results of the CDMS-Ge, XENON, and LUX detectors may be in tension with the potential detections for certain dark matter scenarios and assuming a certain light response. We propose the use of a new class of biological dark matter (DM) detectors to further examine this light dark matter hypothesis, taking advantage of new signatures with low atomic number targets. Two types of biological DM detectors are discussed here: DNA-based detectors and enzymatic reactions (ER) based detectors. In the case of DNA-based detectors, we discuss a new implementation. In the case of ER detectors, there are four crucial phases of the detection process: (a) change of state due to energy deposited by a particle; (b) amplification due to the release of energy derived from the action of an enzyme on its substrate; (c) sustainable but nonexplosive enzymatic reaction; (d) self-termination due to the denaturation of the enzyme, when the temperature is raised. This paper provides information of how to design as well as optimize these four processes.

Searching for dark absorption with direct detection experiments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bloch, Itay M.; Essig, Rouven; Tobioka, Kohsaku

We consider the absorption by bound electrons of dark matter in the form of dark photons and axion-like particles, as well as of dark photons from the Sun, in current and next-generation direct detection experiments. Experiments sensitive to electron recoils can detect such particles with masses between a few eV to more than 10 keV. For dark photon dark matter, we update a previous bound based on XENON10 data and derive new bounds based on data from XENON100 and CDMSlite. We find these experiments to disfavor previously allowed parameter space. Moreover, we derive sensitivity projections for SuperCDMS at SNOLAB formore » silicon and germanium targets, as well as for various possible experiments with scintillating targets (cesium iodide, sodium iodide, and gallium arsenide). The projected sensitivity can probe large new regions of parameter space. For axion-like particles, the same current direction detection data improves on previously known direct-detection constraints but does not bound new parameter space beyond known stellar cooling bounds. However, projected sensitivities of the upcoming SuperCDMS SNOLAB using germanium can go beyond these and even probe parameter space consistent with possible hints from the white dwarf luminosity function. We find similar results for dark photons from the sun. For all cases, direct-detection experiments can have unprecedented sensitivity to dark-sector particles.« less

Characterization of soybean protein hydrolysates able to promote the proliferation of Streptococcus thermophilus ST.

PubMed

Hongfei, Zhao; Fengling, Bai; Fang, Zhou; Walczak, Piotr; Xiangning, Jiang; Bolin, Zhang

2013-04-01

How soybean protein hydrolysates (SPHs) to favor the growth of S. thermophilus ST were investigated. Hydrolyzed soybean protein was fractionated to 4 fragments, that is, SPH-I, SPH-II, SPH-III, and SPH-IV according to their molecular weight sizes. SPHs can improve the growth of strain ST, in which SPH-IV, with the molecular weight of less than 5 kD, significantly promoted the growth of strain ST. The cell counts of strain ST grew quickly from 7.71 to 9.78 (log CFU/mL) when the concentrations of SPH-IV ranging from 0% to 1%. Moreover, 2 chemically defined media (CDMs) were used to test their roles in maintaining the viability of strain ST. CDMs only maintained the survival of strain ST, but SPH-IV had the promotional effects on proliferation of the bacteria. SPH-IV was further characterized to be oligopeptides that contain 2 to 8 amino acids and free amino acids by high-performance liquid chromatography-mass spectrometry (HPLC-MS) analysis. The amino acid compositions showed that SPH-IV contained more essential amino acids, which were necessary for the growth of S. thermophilus ST. Clearly, SPH-IV could be used as an exogenous nitrogen supplement to enhance the proliferation of S. thermophilus ST and other lactic acid bacteria, and the data from small scale-up fermentation also supported this point. © 2013 Institute of Food Technologists®

Nonlinear optimal filter technique for analyzing energy depositions in TES sensors driven into saturation

DOE PAGES

Shank, B.; Yen, J. J.; Cabrera, B.; ...

2014-11-04

We present a detailed thermal and electrical model of superconducting transition edge sensors (TESs) connected to quasiparticle (qp) traps, such as the W TESs connected to Al qp traps used for CDMS (Cryogenic Dark Matter Search) Ge and Si detectors. We show that this improved model, together with a straightforward time-domain optimal filter, can be used to analyze pulses well into the nonlinear saturation region and reconstruct absorbed energies with optimal energy resolution.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cembranos, Jose A. R.; Diaz-Cruz, J. Lorenzo; Prado, Lilian

Dark Matter direct detection experiments are able to exclude interesting parameter space regions of particle models which predict an important amount of thermal relics. We use recent data to constrain the branon model and to compute the region that is favored by CDMS measurements. Within this work, we also update present colliders constraints with new studies coming from the LHC. Despite the present low luminosity, it is remarkable that for heavy branons, CMS and ATLAS measurements are already more constraining than previous analyses performed with TEVATRON and LEP data.

Application of Cryocoolers to a Vintage Dilution Refrigerator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schmitt, Richard; Smith, Gary; Ruschman, Mark

2011-06-06

A dilution refrigerator is required for 50mK detector operation of CDMS (Cryogenic Dark Matter Search). Besides shielding the dilution refrigerator itself, the liquid nitrogen shield and liquid helium bath in the refrigerator cool the detector cryostat heat shields and cool electronics, resulting in significant external heat loads at 80K and at 4K. An Oxford Instruments Kelvinox 400 has served this role for ten years but required daily transfers of liquid nitrogen and liquid helium. Complicating the cryogen supply is the location 800 meters below ground in an RF shielded, class 10000 clean room at Soudan, MN. Nitrogen and helium re-liquefiersmore » using cryocoolers were installed outside the clean room and continuously condense room temperature gas and return the liquids to the dilution refrigerator through a transfer line. This paper will describe the design, installation, controls and performance of liquefaction systems.« less

Cost-effectiveness analysis of interferon beta-1b for the treatment of patients with a first clinical event suggestive of multiple sclerosis.

PubMed

Caloyeras, John P; Zhang, Bin; Wang, Cheng; Eriksson, Marianne; Fredrikson, Sten; Beckmann, Karola; Knappertz, Volker; Pohl, Christoph; Hartung, Hans-Peter; Shah, Dhvani; Miller, Jeffrey D; Sandbrink, Rupert; Lanius, Vivian; Gondek, Kathleen; Russell, Mason W

2012-05-01

To assess, from a Swedish societal perspective, the cost effectiveness of interferon β-1b (IFNB-1b) after an initial clinical event suggestive of multiple sclerosis (MS) (ie, early treatment) compared with treatment after onset of clinically definite MS (CDMS) (ie, delayed treatment). A Markov model was developed, using patient level data from the BENEFIT trial and published literature, to estimate health outcomes and costs associated with IFNB-1b for hypothetical cohorts of patients after an initial clinical event suggestive of MS. Health states were defined by Kurtzke Expanded Disability Status Scale (EDSS) scores. Model outcomes included quality-adjusted life years (QALYs), total costs (including both direct and indirect costs), and incremental cost-effectiveness ratios. Sensitivity analyses were performed on key model parameters to assess the robustness of model results. In the base case scenario, early IFNB-1b treatment was economically dominant (ie, less costly and more effective) versus delayed IFNB-1b treatment when QALYs were used as the effectiveness metric. Sensitivity analyses showed that the cost-effectiveness results were sensitive to model time horizon. Compared with the delayed treatment strategy, early treatment of MS was also associated with delayed EDSS progressions, prolonged time to CDMS diagnosis, and a reduction in frequency of relapse. Early treatment with IFNB-1b for a first clinical event suggestive of MS was found to improve patient outcomes while controlling costs. Copyright © 2012 Elsevier HS Journals, Inc. All rights reserved.

The Cold Dark Matter Search test stand warm electronics card

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hines, Bruce; /Colorado U., Denver; Hansen, Sten

A card which does the signal processing for four SQUID amplifiers and two charge sensitive channels is described. The card performs the same functions as is presently done with two custom 9U x 280mm Eurocard modules, a commercial multi-channel VME digitizer, a PCI to GPIB interface, a PCI to VME interface and a custom built linear power supply. By integrating these functions onto a single card and using the power over Ethernet standard, the infrastructure requirements for instrumenting a Cold Dark Matter Search (CDMS) detector test stand are significantly reduced.

B cell expression of the inhibitory Fc gamma receptor is unchanged in early MS.

PubMed

Comabella, Manuel; Montalban, Xavier; Kakalacheva, Kristina; Osman, Deeqa; Nimmerjahn, Falk; Tintoré, Mar; Lünemann, Jan D

2010-06-01

Expression of the inhibitory Fcgamma receptor IIB (FcgammaRIIB) has emerged as a late checkpoint during peripheral B cell development which prevents autoreactive memory B lymphocytes from becoming long-lived plasma cells. Decreased expression of FcgammaRIIB or non-functional FcgammaRIIB variants are associated with the development of autoimmune tissue inflammation. We determined the expression profile of FcgammaRIIB in peripheral blood cells in treatment-naïve patients with early MS. Twenty-five patients with clinically isolated syndrome (CIS) who converted to clinically definite MS (CDMS) and 25 demographically matched healthy donors were included in the study. Frequencies of peripheral blood monocytes and B cell subsets as well as FcgammaRIIB expression profile was determined by flow cytometry. FcgammaRIIB expression levels were higher in B cells compared to monocytes (p<0.0001) and higher in memory B cells compared to their naïve counterparts (p<0.0001). However, FcgammaRIIB expression in naïve and memory B cells as well as monocytes was unchanged in patients with early MS at onset of symptoms as well as after conversion to CDMS compared to controls. No significant correlations were found between FcgammaRIIB expression levels and brain MRI-derived metrics or EDSS progression during follow-up. These data indicate that FcgammaRIIB expression, a critical late B cell differentiation checkpoint preventing the occurrence of autoreactive long-lived plasma cells, is not impaired in treatment-naïve patients with MS, at least in the early phases of the disease. Copyright 2010 Elsevier B.V. All rights reserved.

Exclusion limits on the WIMP nucleon elastic scattering cross-section from the Cryogenic Dark Matter Search

DOE Office of Scientific and Technical Information (OSTI.GOV)

Golwala, Sunil Ramanlal

2000-01-01

Extensive evidence indicates that a large fraction of the matter in the universe is nonluminous, nonbaryonic, and “cold” — nonrelativistic at the time matter began to dominate the energy density of the universe. Weakly Interacting Massive Particles (WIMPs) are an excellent candidate for nonbaryonic, cold dark matter. Minimal supersymmetry provides a natural WIMP candidate in the form of the lightest superpartner, with a typical mass Mδ ~ 100 GeV c-2 . WIMPs are expected to have collapsed into a roughly isothermal, spherical halo within which the visible portion of our galaxy resides. They would scatter off nuclei via the weakmore » interaction, potentially allowingtheir direct detection. The Cryogenic Dark Matter Search (CDMS) employs Ge and Si detectors to search for WIMPs via their elastic-scatteringinteractions with nuclei while discriminatingagainst interactions of background particles. The former yield nuclear recoils while the latter produce electron recoils. The ionization yield (the ratio of ionization production to recoil energy in a semiconductor) of a particle interaction differs greatly for nuclear and electron recoils. CDMS detectors measure phonon and electron-hole-pair production to determine recoil energy and ionization yield for each event and thereby discriminate nuclear recoils from electron recoils. This dissertation reports new limits on the spin-independent WIMP-nucleon elastic-scattering cross section that exclude unexplored parameter space above 10 GeV c-2 WIMP mass and, at > 75% CL, the entire 3σ allowed region for the WIMP signal reported by the DAMA experiment. The experimental apparatus, detector performance, and data analysis are fully described.« less

Results from the Super Cryogenic Dark Matter Search Experiment at Soudan

DOE PAGES

Agnese, R.; Aramaki, T.; Arnquist, I. J.; ...

2018-02-09

Here, we report the result of a blinded search for weakly interacting massive particles (WIMPs) using the majority of the SuperCDMS Soudan data set. With an exposure of 1690 kg d, a single candidate event is observed, consistent with expected backgrounds. This analysis (combined with previous Ge results) sets an upper limit on the spin-independent WIMP–nucleon cross section of 1.4×10 -44 (1.0×10 -44) cm 2 at 46 GeV/c 2. These results set the strongest limits for WIMP–germanium-nucleus interactions for masses >12 GeV/c 2.

Results from the Super Cryogenic Dark Matter Search Experiment at Soudan

NASA Astrophysics Data System (ADS)

Agnese, R.; Aramaki, T.; Arnquist, I. J.; Baker, W.; Balakishiyeva, D.; Banik, S.; Barker, D.; Basu Thakur, R.; Bauer, D. A.; Binder, T.; Bowles, M. A.; Brink, P. L.; Bunker, R.; Cabrera, B.; Caldwell, D. O.; Calkins, R.; Cartaro, C.; Cerdeño, D. G.; Chang, Y.; Chen, Y.; Cooley, J.; Cornell, B.; Cushman, P.; Daal, M.; Di Stefano, P. C. F.; Doughty, T.; Fascione, E.; Figueroa-Feliciano, E.; Fritts, M.; Gerbier, G.; Germond, R.; Ghaith, M.; Godfrey, G. L.; Golwala, S. R.; Hall, J.; Harris, H. R.; Hong, Z.; Hoppe, E. W.; Hsu, L.; Huber, M. E.; Iyer, V.; Jardin, D.; Jastram, A.; Jena, C.; Kelsey, M. H.; Kennedy, A.; Kubik, A.; Kurinsky, N. A.; Loer, B.; Lopez Asamar, E.; Lukens, P.; MacDonell, D.; Mahapatra, R.; Mandic, V.; Mast, N.; Miller, E. H.; Mirabolfathi, N.; Mohanty, B.; Morales Mendoza, J. D.; Nelson, J.; Orrell, J. L.; Oser, S. M.; Page, K.; Page, W. A.; Partridge, R.; Penalver Martinez, M.; Pepin, M.; Phipps, A.; Poudel, S.; Pyle, M.; Qiu, H.; Rau, W.; Redl, P.; Reisetter, A.; Reynolds, T.; Roberts, A.; Robinson, A. E.; Rogers, H. E.; Saab, T.; Sadoulet, B.; Sander, J.; Schneck, K.; Schnee, R. W.; Scorza, S.; Senapati, K.; Serfass, B.; Speller, D.; Stein, M.; Street, J.; Tanaka, H. A.; Toback, D.; Underwood, R.; Villano, A. N.; von Krosigk, B.; Welliver, B.; Wilson, J. S.; Wilson, M. J.; Wright, D. H.; Yellin, S.; Yen, J. J.; Young, B. A.; Zhang, X.; Zhao, X.; SuperCDMS Collaboration

2018-02-01

We report the result of a blinded search for weakly interacting massive particles (WIMPs) using the majority of the SuperCDMS Soudan data set. With an exposure of 1690 kg d, a single candidate event is observed, consistent with expected backgrounds. This analysis (combined with previous Ge results) sets an upper limit on the spin-independent WIMP-nucleon cross section of 1.4 ×10-44 (1.0 ×10-44) cm2 at 46 GeV /c2 . These results set the strongest limits for WIMP-germanium-nucleus interactions for masses >12 GeV /c2.

Results from the Super Cryogenic Dark Matter Search Experiment at Soudan

DOE Office of Scientific and Technical Information (OSTI.GOV)

Agnese, R.; Aramaki, T.; Arnquist, I. J.

Here, we report the result of a blinded search for weakly interacting massive particles (WIMPs) using the majority of the SuperCDMS Soudan data set. With an exposure of 1690 kg d, a single candidate event is observed, consistent with expected backgrounds. This analysis (combined with previous Ge results) sets an upper limit on the spin-independent WIMP–nucleon cross section of 1.4×10 -44 (1.0×10 -44) cm 2 at 46 GeV/c 2. These results set the strongest limits for WIMP–germanium-nucleus interactions for masses >12 GeV/c 2.

Results from the Super Cryogenic Dark Matter Search Experiment at Soudan

DOE Office of Scientific and Technical Information (OSTI.GOV)

Agnese, R.; Aramaki, T.; Arnquist, I. J.

We report the result of a blinded search for Weakly Interacting Massive Particles (WIMPs) using the full SuperCDMS Soudan dataset. With an exposure of 1690 kg days, a single event was observed after unblinding, consistent with expected backgrounds. This analysis (combined with previous Ge results) sets an upper limit on the spin-independent WIMP-nucleon cross section of 1.4x10^-44 (1.0x10^-44) cm^2 at 46 GeV/c^2 . These results set the strongest limits for WIMP-germanium-nucleus interactions for masses >12 GeV/c^2.

Charged mediators in dark matter scattering

NASA Astrophysics Data System (ADS)

Stengel, Patrick

2017-11-01

We consider a scenario, within the framework of the MSSM, in which dark matter is bino-like and dark matter-nucleon spin-independent scattering occurs via the exchange of light squarks which exhibit left-right mixing. We show that direct detection experiments such as LUX and SuperCDMS will be sensitive to a wide class of such models through spin-independent scattering. The dominant nuclear physics uncertainty is the quark content of the nucleon, particularly the strangeness content. We also investigate parameter space with nearly degenerate neutralino and squark masses, thus enhancing dark matter annihilation and nucleon scattering event rates.

Halo-independent direct detection analyses without mass assumptions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anderson, Adam J.; Fox, Patrick J.; Kahn, Yonatan

2015-10-01

Results from direct detection experiments are typically interpreted by employing an assumption about the dark matter velocity distribution, with results presented in the m{sub χ}−σ{sub n} plane. Recently methods which are independent of the DM halo velocity distribution have been developed which present results in the v{sub min}− g-tilde plane, but these in turn require an assumption on the dark matter mass. Here we present an extension of these halo-independent methods for dark matter direct detection which does not require a fiducial choice of the dark matter mass. With a change of variables from v{sub min} to nuclear recoil momentummore » (p{sub R}), the full halo-independent content of an experimental result for any dark matter mass can be condensed into a single plot as a function of a new halo integral variable, which we call h-tilde (p{sub R}). The entire family of conventional halo-independent g-tilde (v{sub min}) plots for all DM masses are directly found from the single h-tilde (p{sub R}) plot through a simple rescaling of axes. By considering results in h-tilde (p{sub R}) space, one can determine if two experiments are inconsistent for all masses and all physically possible halos, or for what range of dark matter masses the results are inconsistent for all halos, without the necessity of multiple g-tilde (v{sub min}) plots for different DM masses. We conduct a sample analysis comparing the CDMS II Si events to the null results from LUX, XENON10, and SuperCDMS using our method and discuss how the results can be strengthened by imposing the physically reasonable requirement of a finite halo escape velocity.« less

Metabolism of reduced methylated sulfur compounds in anaerobic sediments and by a pure culture of an estuarine methanogen

USGS Publications Warehouse

Kiene, R.P.; Oremland, Ronald S.; Catena, Anthony; Miller, Laurence G.; Capone, D.G.

1986-01-01

Addition of dimethylsulfide (DMS), dimethyldisulfide (DMDS), or methane thiol (MSH) to a diversity of anoxic aquatic sediments (e.g., fresh water, estuarine, alkaline/hypersaline) stimulated methane production. The yield of methane recovered from DMS was often 52 to 63%, although high concentrations of DMS (as well as MSH and DMDS) inhibited methanogenesis in some types of sediments. Production of methane from these reduced methylated sulfur compounds was blocked by 2-bromoethanesulfonic acid. Sulfate did not influence the metabolism of millimolar levels of DMS, DMDS, or MSH added to sediments. However, when DMS was added at ∼2-μM levels as [14C]DMS, metabolism by sediments resulted in a 14CH4/14CO2 ratio of only 0.06. Addition of molybdate increased the ratio to 1.8, while 2-bromoethanesulfonic acid decreased it to 0, but did not block 14CO2 production. These results indicate the methanogens and sulfate reducers compete for DMS when it is present at low concentrations; however, at high concentrations, DMS is a “noncompetitive” substrate for methanogens. Metabolism of DMS by sediments resulted in the appearance of MSH as a transient intermediate. A pure culture of an obligately methylotrophic estuarine methanogen was isolated which was capable of growth on DMS. Metabolism of DMS by the culture also resulted in the transient appearance of MSH, but the organism could grow on neither MSH nor DMDS. The culture metabolized [14C]-DMS to yield a 14CH4/14CO2 ratio of ∼2.8. Reduced methylated sulfur compounds represent a new class of substrates for methanogens and may be potential precursors of methane in a variety of aquatic habitats.

Halo-independent direct detection analyses without mass assumptions

DOE PAGES

Anderson, Adam J.; Fox, Patrick J.; Kahn, Yonatan; ...

2015-10-06

Results from direct detection experiments are typically interpreted by employing an assumption about the dark matter velocity distribution, with results presented in the m χ – σ n plane. Recently methods which are independent of the DM halo velocity distribution have been developed which present results in the v min – g ~ plane, but these in turn require an assumption on the dark matter mass. Here we present an extension of these halo-independent methods for dark matter direct detection which does not require a fiducial choice of the dark matter mass. With a change of variables from v minmore » to nuclear recoil momentum (p R), the full halo-independent content of an experimental result for any dark matter mass can be condensed into a single plot as a function of a new halo integral variable, which we call tilde h(p R). The entire family of conventional halo-independent tilde g ~(v min) plots for all DM masses are directly found from the single tilde h ~(p R) plot through a simple rescaling of axes. By considering results in tildeh ~(p R) space, one can determine if two experiments are inconsistent for all masses and all physically possible halos, or for what range of dark matter masses the results are inconsistent for all halos, without the necessity of multiple tilde g ~(v min) plots for different DM masses. As a result, we conduct a sample analysis comparing the CDMS II Si events to the null results from LUX, XENON10, and SuperCDMS using our method and discuss how the results can be strengthened by imposing the physically reasonable requirement of a finite halo escape velocity.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anderson, Adam J.; Fox, Patrick J.; Kahn, Yonatan

Results from direct detection experiments are typically interpreted by employing an assumption about the dark matter velocity distribution, with results presented in the m{sub χ}−σ{sub n} plane. Recently methods which are independent of the DM halo velocity distribution have been developed which present results in the v{sub min}−g-tilde plane, but these in turn require an assumption on the dark matter mass. Here we present an extension of these halo-independent methods for dark matter direct detection which does not require a fiducial choice of the dark matter mass. With a change of variables from v{sub min} to nuclear recoil momentum (p{submore » R}), the full halo-independent content of an experimental result for any dark matter mass can be condensed into a single plot as a function of a new halo integral variable, which we call h-til-tilde(p{sub R}). The entire family of conventional halo-independent g-tilde(v{sub min}) plots for all DM masses are directly found from the single h-tilde(p{sub R}) plot through a simple rescaling of axes. By considering results in h-tilde(p{sub R}) space, one can determine if two experiments are inconsistent for all masses and all physically possible halos, or for what range of dark matter masses the results are inconsistent for all halos, without the necessity of multiple g-tilde(v{sub min}) plots for different DM masses. We conduct a sample analysis comparing the CDMS II Si events to the null results from LUX, XENON10, and SuperCDMS using our method and discuss how the results can be strengthened by imposing the physically reasonable requirement of a finite halo escape velocity.« less

REPORT OF RESEARCH ACCOMPLISHMENTS AND FUTURE GOALS HIGH ENERGY PHYSICS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wise, Mark B.; Kapustin, Anton N.; Schwarz, John Henry

Caltech High Energy Physics (HEP) has a broad program in both experimental and theoretical physics. We are known for our creativity and leadership. The future is uncertain and we strive to be involved in all the major areas of experimental and theoretical HEP physics so no matter where the important discoveries occur we are well positioned to play an important role. An outstanding group of postdoctoral scholars, graduate students, staff scientists, and technical and administrative personnel support our efforts in experimental and theoretical physics. The PI’s on this grant are involved in the following program of experimental and theoretical activities:more » I) EXPERIMENTAL PHYSICS Our CMS group, led by Harvey Newman and Maria Spiropulu, has played a key role in the discovery and interpretation of the Higgs boson and in searches for new physics. They have important hardware responsibilities in both ECAL and HCAL and are also involved in the upgrades needed for the High Luminosity LHC. Newman's group also develops and operates Grid-based computing, networking, and collaborative systems for CMS and the US HEP community. The charged lepton (Mu2e) and quark BaBar flavor physics group is led by David Hitlin and Frank Porter. On Mu2e they have been instrumental in the design of the calorimeter. Construction responsibilities include one third of the crystals and associated readout as well as the calibration system. They also will have responsibility for a major part of the online system software. Although data taking ceased in 2008 the Caltech BaBar group is active on several new forefront analyses. The neutrino group is led by Ryan Patterson. They are central to NOvA's core oscillation physics program, to calibration, and to detector readiness being responsible for the production and installation of 12,000 APD arrays. They have key roles in neutrino appearance and disappearance analysis in MINOS and MINOS+. Sunil Golwala leads the dark matter direct detection effort. Areas of activity include: CDMS II data analysis, contributions to SuperCDMS Soudan operations and analysis, R&D towards SuperCDMS SNOLAB, development of a novel screener for radiocontamination (the BetaCage), and development of new WIMP detector concepts. Ren-Yuan Zhu leads the HEP crystal laboratory for the advanced detector R&D effort. The crystal lab is involved in development of novel scintillating crystals and has proposed several crystal based detector concepts for future HEP experiments at the energy and intensity frontiers. Its current research effort is concentrated on development of fast crystal scintillators with good radiation hardness and low cost. II) THEORETICAL PHYSICS The main theme of Sergei Gukov's current research is the relation between the geometry of quantum group invariants and their categorification, on the one hand, and the physics of supersymmetric gauge theory and string theory, on the other. Anton Kapustin's research spans a variety of topics in non-perturbative Quantum Field Theory (QFT). His main areas of interest are supersymmetric gauge theories, non-perturbative dualities in QFT, disorder operators, Topological Quantum Field Theory, and non-relativistic QFT. He is also interested in the foundations and possible generalizations of Quantum Mechanics. Hirosi Ooguri's current research has two main components. One is to find exact results in Calabi-Yau compactification of string theory. Another is to explore applications of the AdS/CFT correspondence. He also plans to continue his project with Caltech postdoctoral fellows on BPS spectra of supersymmetric gauge theories in diverse dimensions. John Preskill works on quantum information science. This field may lead to important future technologies, and also lead to new understanding of issues in fundamental physics John Schwarz has been exploring a number of topics in superstring theory/M-theory, supersymmetric gauge theory, and their AdS/CFT relationships. Much of the motivation for these studies is the desire to gain a deeper understanding of superstring theory and M-theory. The research interests of Mark Wise span particle physics, cosmology and nuclear physics. His recent work has centered on extensions of the standard model where baryon number and lepton number are gauged and extensions of the standard model that have novel sources of baryon number violation and new sources of charged lepton flavor violation« less

Advancements to Visualization Control System (VCS, part of UV-CDAT), a Visualization Package Designed for Climate Scientists

NASA Astrophysics Data System (ADS)

Lipsa, D.; Chaudhary, A.; Williams, D. N.; Doutriaux, C.; Jhaveri, S.

2017-12-01

Climate Data Analysis Tools (UV-CDAT, https://uvcdat.llnl.gov) is a data analysis and visualization software package developed at Lawrence Livermore National Laboratory and designed for climate scientists. Core components of UV-CDAT include: 1) Community Data Management System (CDMS) which provides I/O support and a data model for climate data;2) CDAT Utilities (GenUtil) that processes data using spatial and temporal averaging and statistic functions; and 3) Visualization Control System (VCS) for interactive visualization of the data. VCS is a Python visualization package primarily built for climate scientists, however, because of its generality and breadth of functionality, it can be a useful tool to other scientific applications. VCS provides 1D, 2D and 3D visualization functions such as scatter plot and line graphs for 1d data, boxfill, meshfill, isofill, isoline for 2d scalar data, vector glyphs and streamlines for 2d vector data and 3d_scalar and 3d_vector for 3d data. Specifically for climate data our plotting routines include projections, Skew-T plots and Taylor diagrams. While VCS provided a user-friendly API, the previous implementation of VCS relied on slow performing vector graphics (Cairo) backend which is suitable for smaller dataset and non-interactive graphics. LLNL and Kitware team has added a new backend to VCS that uses the Visualization Toolkit (VTK) as its visualization backend. VTK is one of the most popular open source, multi-platform scientific visualization library written in C++. Its use of OpenGL and pipeline processing architecture results in a high performant VCS library. Its multitude of available data formats and visualization algorithms results in easy adoption of new visualization methods and new data formats in VCS. In this presentation, we describe recent contributions to VCS that includes new visualization plots, continuous integration testing using Conda and CircleCI, tutorials and examples using Jupyter notebooks as well as upgrades that we are planning in the near future which will improve its ease of use and reliability and extend its capabilities.

Projected sensitivity of the SuperCDMS SNOLAB experiment

DOE PAGES

Agnese, R.; Anderson, A. J.; Aramaki, T.; ...

2017-04-07

SuperCDMS SNOLAB will be a next-generation experiment aimed at directly detecting low-mass particles (with masses ≤10 GeV/c 2) that may constitute dark matter by using cryogenic detectors of two types (HV and iZIP) and two target materials (germanium and silicon). The experiment is being designed with an initial sensitivity to nuclear recoil cross sections ~1×10 –43 cm 2 for a dark matter particle mass of 1 GeV/c 2, and with capacity to continue exploration to both smaller masses and better sensitivities. The phonon sensitivity of the HV detectors will be sufficient to detect nuclear recoils from sub-GeV dark matter. Amore » detailed calibration of the detector response to low-energy recoils will be needed to optimize running conditions of the HV detectors and to interpret their data for dark matter searches. Low-activity shielding, and the depth of SNOLAB, will reduce most backgrounds, but cosmogenically produced 3H and naturally occurring 32Si will be present in the detectors at some level. Even if these backgrounds are 10 times higher than expected, the science reach of the HV detectors would be over 3 orders of magnitude beyond current results for a dark matter mass of 1 GeV/c 2. The iZIP detectors are relatively insensitive to variations in detector response and backgrounds, and will provide better sensitivity for dark matter particles with masses ≳5 GeV/c 2. The mix of detector types (HV and iZIP), and targets (germanium and silicon), planned for the experiment, as well as flexibility in how the detectors are operated, will allow us to maximize the low-mass reach, and understand the backgrounds that the experiment will encounter. In conclusion, upgrades to the experiment, perhaps with a variety of ultra-low-background cryogenic detectors, will extend dark matter sensitivity down to the “neutrino floor,” where coherent scatters of solar neutrinos become a limiting background.« less

The financial attractiveness assessment of large waste management projects registered as clean development mechanism

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bufoni, André Luiz, E-mail: bufoni@facc.ufrj.br; Oliveira, Luciano Basto; Rosa, Luiz Pinguelli

Highlights: • Projects are not financially attractive without registration as CDMs. • WM benchmarks and indicators are converging and reducing in variance. • A sensitivity analysis reveal that revenue has more of an effect on the financial results. • Results indicate that an extensive database would reduce WM project risk and capital costs. • Disclosure standards would make information more comparable worldwide. - Abstract: This study illustrates the financial analyses for demonstration and assessment of additionality presented in the project design (PDD) and enclosed documents of the 431 large Clean Development Mechanisms (CDM) classified as the ‘waste handling and disposalmore » sector’ (13) over the past ten years (2004–2014). The expected certified emissions reductions (CER) of these projects total 63.54 million metric tons of CO{sub 2}eq, where eight countries account for 311 projects and 43.36 million metric tons. All of the projects declare themselves ‘not financially attractive’ without CER with an estimated sum of negative results of approximately a half billion US$. The results indicate that WM benchmarks and indicators are converging and reducing in variance, and the sensitivity analysis reveals that revenues have a greater effect on the financial results. This work concludes that an extensive financial database with simple standards for disclosure would greatly diminish statement problems and make information more comparable, reducing the risk and capital costs of WM projects.« less

ExoMol line list - XXI. Nitric Oxide (NO)

NASA Astrophysics Data System (ADS)

Wong, Andy; Yurchenko, Sergei N.; Bernath, Peter; Müller, Holger S. P.; McConkey, Stephanie; Tennyson, Jonathan

2017-09-01

Line lists for the X 2Π electronic ground state for the parent isotopologue of nitric oxide (14N16O) and five other major isotopologues (14N17O, 14N18O, 15N16O, 15N17O and 15N18O) are presented. The line lists are constructed using empirical energy levels (and line positions) and high-level ab initio intensities. The energy levels were obtained using a combination of two approaches, from an effective Hamiltonian and from solving the rovibronic Schrödinger equation variationally. The effective Hamiltonian model was obtained through a fit to the experimental line positions of NO available in the literature for all six isotopologues using the programs spfit and spcat. The variational model was built through a least squares fit of the ab initio potential and spin-orbit curves to the experimentally derived energies and experimental line positions of the main isotopologue only using the duo program. The ab initio potential energy, spin-orbit and dipole moment curves (PEC, SOC and DMC) are computed using high-level ab initio methods and the marvel method is used to obtain energies of NO from experimental transition frequencies. The line lists are constructed for each isotopologue based on the use of the most accurate energy levels and the ab initio DMC. Each line list covers a wavenumber range from 0 to 40 000 cm-1 with approximately 22 000 rovibronic states and 2.3-2.6 million transitions extending to Jmax = 184.5 and vmax = 51. Partition functions are also calculated up to a temperature of 5000 K. The calculated absorption line intensities at 296 K using these line lists show excellent agreement with those included in the HITRAN and HITEMP data bases. The computed NO line lists are the most comprehensive to date, covering a wider wavenumber and temperature range compared to both the HITRAN and HITEMP data bases. These line lists are also more accurate than those used in HITEMP. The full line lists are available from the CDS http://cdsarc.u-strasbg.fr and ExoMol www.exomol.com data bases; data will also be available from CDMS http://www.cdms.de.

Operational support to collision avoidance activities by ESA's space debris office

NASA Astrophysics Data System (ADS)

Braun, V.; Flohrer, T.; Krag, H.; Merz, K.; Lemmens, S.; Bastida Virgili, B.; Funke, Q.

2016-09-01

The European Space Agency's (ESA) Space Debris Office provides a service to support operational collision avoidance activities. This support currently covers ESA's missions Cryosat-2, Sentinel-1A and -2A, the constellation of Swarm-A/B/C in low-Earth orbit (LEO), as well as missions of third-party customers. In this work, we describe the current collision avoidance process for ESA and third-party missions in LEO. We give an overview on the upgrades developed and implemented since the advent of conjunction summary messages (CSM)/conjunction data messages (CDM), addressing conjunction event detection, collision risk assessment, orbit determination, orbit and covariance propagation, process control, and data handling. We pay special attention to the effect of warning thresholds on the risk reduction and manoeuvre rates, as they are established through risk mitigation and analysis tools, such as ESA's Debris Risk Assessment and Mitigation Analysis (DRAMA) software suite. To handle the large number of CDMs and the associated risk analyses, a database-centric approach has been developed. All CDMs and risk analysis results are stored in a database. In this way, a temporary local "mini-catalogue" of objects close to our target spacecraft is obtained, which can be used, e.g., for manoeuvre screening and to update the risk analysis whenever a new ephemeris becomes available from the flight dynamics team. The database is also used as the backbone for a Web-based tool, which consists of the visualization component and a collaboration tool that facilitates the status monitoring and task allocation within the support team as well as communication with the control team. The visualization component further supports the information sharing by displaying target and chaser motion over time along with the involved uncertainties. The Web-based solution optimally meets the needs for a concise and easy-to-use way to obtain a situation picture in a very short time, and the support for third-party missions not operated from the European Space Operations Centre (ESOC). Finally, we provide statistics on the identified conjunction events, taking into account the known significant changes in the LEO orbital environment and share ESA's experience along with recent examples.

Control-display mapping in brain-computer interfaces.

PubMed

Thurlings, Marieke E; van Erp, Jan B F; Brouwer, Anne-Marie; Blankertz, Benjamin; Werkhoven, Peter

2012-01-01

Event-related potential (ERP) based brain-computer interfaces (BCIs) employ differences in brain responses to attended and ignored stimuli. When using a tactile ERP-BCI for navigation, mapping is required between navigation directions on a visual display and unambiguously corresponding tactile stimuli (tactors) from a tactile control device: control-display mapping (CDM). We investigated the effect of congruent (both display and control horizontal or both vertical) and incongruent (vertical display, horizontal control) CDMs on task performance, the ERP and potential BCI performance. Ten participants attended to a target (determined via CDM), in a stream of sequentially vibrating tactors. We show that congruent CDM yields best task performance, enhanced the P300 and results in increased estimated BCI performance. This suggests a reduced availability of attentional resources when operating an ERP-BCI with incongruent CDM. Additionally, we found an enhanced N2 for incongruent CDM, which indicates a conflict between visual display and tactile control orientations. Incongruency in control-display mapping reduces task performance. In this study, brain responses, task and system performance are related to (in)congruent mapping of command options and the corresponding stimuli in a brain-computer interface (BCI). Directional congruency reduces task errors, increases available attentional resources, improves BCI performance and thus facilitates human-computer interaction.

A web-based decision support tool for prognosis simulation in multiple sclerosis.

PubMed

Veloso, Mário

2014-09-01

A multiplicity of natural history studies of multiple sclerosis provides valuable knowledge of the disease progression but individualized prognosis remains elusive. A few decision support tools that assist the clinician in such task have emerged but have not received proper attention from clinicians and patients. The objective of the current work is to implement a web-based tool, conveying decision relevant prognostic scientific evidence, which will help clinicians discuss prognosis with individual patients. Data were extracted from a set of reference studies, especially those dealing with the natural history of multiple sclerosis. The web-based decision support tool for individualized prognosis simulation was implemented with NetLogo, a program environment suited for the development of complex adaptive systems. Its prototype has been launched online; it enables clinicians to predict both the likelihood of CIS to CDMS conversion, and the long-term prognosis of disability level and SPMS conversion, as well as assess and monitor the effects of treatment. More robust decision support tools, which convey scientific evidence and satisfy the needs of clinical practice by helping clinicians discuss prognosis expectations with individual patients, are required. The web-based simulation model herein introduced proposes to be a step forward toward this purpose. Copyright © 2014 Elsevier B.V. All rights reserved.

Search for low-mass WIMPs in a 0.6 kg day exposure of the DAMIC experiment at SNOLAB

NASA Astrophysics Data System (ADS)

Aguilar-Arevalo, A.; Amidei, D.; Bertou, X.; Butner, M.; Cancelo, G.; Castañeda Vázquez, A.; Cervantes Vergara, B. A.; Chavarria, A. E.; Chavez, C. R.; de Mello Neto, J. R. T.; D'Olivo, J. C.; Estrada, J.; Fernandez Moroni, G.; Gaïor, R.; Guardincerri, Y.; Hernández Torres, K. P.; Izraelevitch, F.; Kavner, A.; Kilminster, B.; Lawson, I.; Letessier-Selvon, A.; Liao, J.; Mello, V. B. B.; Molina, J.; Peña, J. R.; Privitera, P.; Ramanathan, K.; Sarkis, Y.; Schwarz, T.; Sengul, C.; Settimo, M.; Sofo Haro, M.; Thomas, R.; Tiffenberg, J.; Tiouchichine, E.; Torres Machado, D.; Trillaud, F.; You, X.; Zhou, J.; Damic Collaboration

2016-10-01

We present results of a dark matter search performed with a 0.6 kg d exposure of the DAMIC experiment at the SNOLAB underground laboratory. We measure the energy spectrum of ionization events in the bulk silicon of charge-coupled devices down to a signal of 60 eV electron equivalent. The data are consistent with radiogenic backgrounds, and constraints on the spin-independent WIMP-nucleon elastic-scattering cross section are accordingly placed. A region of parameter space relevant to the potential signal from the CDMS-II Si experiment is excluded using the same target for the first time. This result obtained with a limited exposure demonstrates the potential to explore the low-mass WIMP region (<10 GeV c-2 ) with the upcoming DAMIC100, a 100 g detector currently being installed in SNOLAB.

Information matrix estimation procedures for cognitive diagnostic models.

PubMed

Liu, Yanlou; Xin, Tao; Andersson, Björn; Tian, Wei

2018-03-06

Two new methods to estimate the asymptotic covariance matrix for marginal maximum likelihood estimation of cognitive diagnosis models (CDMs), the inverse of the observed information matrix and the sandwich-type estimator, are introduced. Unlike several previous covariance matrix estimators, the new methods take into account both the item and structural parameters. The relationships between the observed information matrix, the empirical cross-product information matrix, the sandwich-type covariance matrix and the two approaches proposed by de la Torre (2009, J. Educ. Behav. Stat., 34, 115) are discussed. Simulation results show that, for a correctly specified CDM and Q-matrix or with a slightly misspecified probability model, the observed information matrix and the sandwich-type covariance matrix exhibit good performance with respect to providing consistent standard errors of item parameter estimates. However, with substantial model misspecification only the sandwich-type covariance matrix exhibits robust performance. © 2018 The British Psychological Society.

CARA Status and Upcoming Enhancements

NASA Technical Reports Server (NTRS)

Johnson, Megan

2017-01-01

CAS 8.4.3 was deployed to operations on 13 June 2017. Discrepancies Between 3D Pc Estimates and advanced Monte Carlo Equinoctial-Sampling Pc Estimates discovered and discussed at 23 May 2017 Useras (Registered Trademark) Forum. The patch created the Reporting Pc, which is the greater value between the calculated 2D and 3D Pc values This changed the Pc reported in the CDMs to the Reporting Pc This changed the Pc reported on the Summary Report to the Reporting Pc This changed the Pc reported on Maneuver Screening Analysis (MSA) Report to the Reporting Pc. Both the 2D and 3D Pc added to the Summary Report details section The patch also updated the 3D Pc algorithm to eliminate velocity covariance from the Pc calculation This will bring 2D and 3D Pc into close alignment for vast majority of events, particularly for the events in which the 2D/3D discrepancy was found.

Search for low-mass WIMPs in a 0.6 kg day exposure of the DAMIC experiment at SNOLAB

DOE PAGES

Aguilar-Arevalo, A.

2016-10-27

In this paper, we present results of a dark matter search performed with a 0.6 kg d exposure of the DAMIC experiment at the SNOLAB underground laboratory. We measure the energy spectrum of ionization events in the bulk silicon of charge-coupled devices down to a signal of 60 eV electron equivalent. The data are consistent with radiogenic backgrounds, and constraints on the spin-independent WIMP-nucleon elastic-scattering cross section are accordingly placed. A region of parameter space relevant to the potential signal from the CDMS-II Si experiment is excluded using the same target for the first time. This result obtained with a limited exposure demonstratesmore » the potential to explore the low-mass WIMP region (<10 GeV c -2) with the upcoming DAMIC100, a 100 g detector currently being installed in SNOLAB.« less

Two-Dimensional Spatial Imaging of Charge Transport in Germanium Crystals at Cryogenic Temperatures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moffatt, Robert

2016-03-01

In this dissertation, I describe a novel apparatus for studying the transport of charge in semiconductors at cryogenic temperatures. The motivation to conduct this experiment originated from an asymmetry observed between the behavior of electrons and holes in the germanium detector crystals used by the Cryogenic Dark Matter Search (CDMS). This asymmetry is a consequence of the anisotropic propagation of electrons in germanium at cryogenic temperatures. To better model our detectors, we incorporated this effect into our Monte Carlo simulations of charge transport. The purpose of the experiment described in this dissertation is to test those models in detail. Ourmore » measurements have allowed us to discover a shortcoming in our most recent Monte Carlo simulations of electrons in germanium. This discovery would not have been possible without the measurement of the full, two-dimensional charge distribution, which our experimental apparatus has allowed for the first time at cryogenic temperatures.« less

Integrating clinical research with the Healthcare Enterprise: from the RE-USE project to the EHR4CR platform.

PubMed

El Fadly, AbdenNaji; Rance, Bastien; Lucas, Noël; Mead, Charles; Chatellier, Gilles; Lastic, Pierre-Yves; Jaulent, Marie-Christine; Daniel, Christel

2011-12-01

There are different approaches for repurposing clinical data collected in the Electronic Healthcare Record (EHR) for use in clinical research. Semantic integration of "siloed" applications across domain boundaries is the raison d'être of the standards-based profiles developed by the Integrating the Healthcare Enterprise (IHE) initiative - an initiative by healthcare professionals and industry promoting the coordinated use of established standards such as DICOM and HL7 to address specific clinical needs in support of optimal patient care. In particular, the combination of two IHE profiles - the integration profile "Retrieve Form for Data Capture" (RFD), and the IHE content profile "Clinical Research Document" (CRD) - offers a straightforward approach to repurposing EHR data by enabling the pre-population of the case report forms (eCRF) used for clinical research data capture by Clinical Data Management Systems (CDMS) with previously collected EHR data. Implement an alternative solution of the RFD-CRD integration profile centered around two approaches: (i) Use of the EHR as the single-source data-entry and persistence point in order to ensure that all the clinical data for a given patient could be found in a single source irrespective of the data collection context, i.e. patient care or clinical research; and (ii) Maximize the automatic pre-population process through the use of a semantic interoperability services that identify duplicate or semantically-equivalent eCRF/EHR data elements as they were collected in the EHR context. The RE-USE architecture and associated profiles are focused on defining a set of scalable, standards-based, IHE-compliant profiles that can enable single-source data collection/entry and cross-system data reuse through semantic integration. Specifically, data reuse is realized through the semantic mapping of data collection fields in electronic Case Report Forms (eCRFs) to data elements previously defined as part of patient care-centric templates in the EHR context. The approach was evaluated in the context of a multi-center clinical trial conducted in a large, multi-disciplinary hospital with an installed EHR. Data elements of seven eCRFs used in a multi-center clinical trial were mapped to data elements of patient care-centric templates in use in the EHR at the George Pompidou hospital. 13.4% of the data elements of the eCRFs were found to be represented in EHR templates and were therefore candidate for pre-population. During the execution phase of the clinical study, the semantic mapping architecture enabled data persisted in the EHR context as part of clinical care to be used to pre-populate eCRFS for use without secondary data entry. To ensure that the pre-populated data is viable for use in the clinical research context, all pre-populated eCRF data needs to be first approved by a trial investigator prior to being persisted in a research data store within a CDMS. Single-source data entry in the clinical care context for use in the clinical research context - a process enabled through the use of the EHR as single point of data entry, can - if demonstrated to be a viable strategy - not only significantly reduce data collection efforts while simultaneously increasing data collection accuracy secondary to elimination of transcription or double-entry errors between the two contexts but also ensure that all the clinical data for a given patient, irrespective of the data collection context, are available in the EHR for decision support and treatment planning. The RE-USE approach used mapping algorithms to identify semantic coherence between clinical care and clinical research data elements and pre-populate eCRFs. The RE-USE project utilized SNOMED International v.3.5 as its "pivot reference terminology" to support EHR-to-eCRF mapping, a decision that likely enhanced the "recall" of the mapping algorithms. The RE-USE results demonstrate the difficult challenges involved in semantic integration between the clinical care and clinical research contexts. Copyright © 2011 Elsevier Inc. All rights reserved.

Update on clinically isolated syndrome.

PubMed

Thouvenot, Éric

2015-04-01

Optic neuritis, myelitis and brainstem syndrome accompanied by a symptomatic MRI T2 or FLAIR hyperintensity and T1 hypointensity are highly suggestive of multiple sclerosis (MS) in young adults. They are called "clinically isolated syndrome" (CIS) and correspond to the typical first multiple sclerosis (MS) episode, especially when associated with other asymptomatic demyelinating lesions, without clinical, radiological and immunological sign of differential diagnosis. After a CIS, the delay of apparition of a relapse, which corresponds to the conversion to clinically definite MS (CDMS), varies from several months to more than 10 years (10-15% of cases, generally called benign RRMS). This delay is generally associated with the number and location of demyelinating lesions of the brain and spinal cord and the results of CSF analysis. Several studies comparing different MRI criteria for dissemination in space and dissemination in time of demyelinating lesions, two hallmarks of MS, provided enough substantial data to update diagnostic criteria for MS after a CIS. In the last revision of the McDonald's criteria in 2010, diagnostic criteria were simplified and now the diagnosis can be made by a single initial scan that proves the presence of active asymptomatic lesions (with gadolinium enhancement) and of unenhanced lesions. However, time to conversion remains highly unpredictable for a given patient and CIS can remain isolated, especially for idiopathic unilateral optic neuritis or myelitis. Univariate analyses of clinical, radiological, biological or electrophysiological characteristics of CIS patients in small series identified numerous risk factors of rapid conversion to MS. However, large series of CIS patients analyzing several characteristics of CIS patients and the influence of disease modifying therapies brought important information about the risk of CDMS or RRMS over up to 20 years of follow-up. They confirmed the importance of the initial MRI pattern of demyelinating lesions and of CSF oligoclonal bands. Available treatments of MS (immunomodulators or immunosuppressants) have also shown unequivocal efficacy to slow the conversion to RRMS after a CIS, but they could be unnecessary for patients with benign RRMS. Beyond diagnostic criteria, knowledge of established and potential risk factors of conversion to MS and of disability progression is essential for CIS patients' follow-up and initiation of disease modifying therapies. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

Smoking and multiple sclerosis: A systematic review and meta-analysis using the Bradford Hill criteria for causation.

PubMed

Degelman, Michelle L; Herman, Katya M

2017-10-01

Despite being one of the most common neurological disorders globally, the cause(s) of multiple sclerosis (MS) remain unknown. Cigarette smoking has been studied with regards to both the development and progression of MS. The Bradford Hill criteria for causation can contribute to a more comprehensive evaluation of a potentially causal risk factor-disease outcome relationship. The objective of this systematic review and meta-analysis was to assess the relationship between smoking and both MS risk and MS progression, subsequently applying Hill's criteria to further evaluate the likelihood of causal associations. The Medline, EMBASE, CINAHL, PsycInfo, and Cochrane Library databases were searched for relevant studies up until July 28, 2015. A random-effects meta-analysis was conducted for three outcomes: MS risk, conversion from clinically isolated syndrome (CIS) to clinically definite multiple sclerosis (CDMS), and progression from relapsing-remitting multiple sclerosis (RRMS) to secondary-progressive multiple sclerosis (SPMS). Dose-response relationships and risk factor interactions, and discussions of mechanisms and analogous associations were noted. Hill's criteria were applied to assess causality of the relationships between smoking and each outcome. The effect of second-hand smoke exposure was also briefly reviewed. Smoking had a statistically significant association with both MS risk (conservative: OR/RR 1.54, 95% CI [1.46-1.63]) and SPMS risk (HR 1.80, 95% CI [1.04-3.10]), but the association with progression from CIS to CDMS was non-significant (HR 1.13, 95% CI [0.73-1.76]). Using Hill's criteria, there was strong evidence of a causal role of smoking in MS risk, but only moderate evidence of a causal association between smoking and MS progression. Heterogeneity in study designs and target populations, inconsistent results, and an overall scarcity of studies point to the need for more research on second-hand smoke exposure in relation to MS prior to conducting a detailed meta-analysis. This first review to supplement systematic review and meta-analytic methods with Hill's criteria to analyze the smoking-MS association provides evidence supporting the causal involvement of smoking in the development and progression of MS. Smoking prevention and cessation programs and policies should consider MS as an additional health risk when aiming to reduce smoking prevalence in the population. Copyright © 2017 Elsevier B.V. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grate, Jay W.; Bliss, Mary; Farmer, Orville T.

Ultra low-background radiation measurements are essential to several large-scale physics investigations, such as those involving neutrinoless double-beta decay, dark matter detection (such as SuperCDMS), and solar neutrino detection. There is a need for electrically and thermally insulating dielectric materials with extremely low-background radioactivity for detector construction. This need is best met with plastics. Most currently available structural plastics have milliBecquerel-per-kilogram total intrinsic radioactivity. Modern low-level detection systems require a large variety of plastics with low microBecquerel-per-kilogram levels. However, the assay of polymer materials for extremely low levels of radioactive elements, uranium and thorium in particular, presents new challenges. It ismore » only recently that any certified reference materials (CRMs) for toxic metals such as lead or cadmium in plastics have become available. However, there are no CRMs for uranium or thorium in thermoplastics. This paper discusses our assessment of the use of laser ablation (LA) for sampling and inductively coupled plasma mass spectrometry (ICP-MS) for analysis of polyethylene (PE) samples, with an emphasis on uranium determination. Using a CRM for lead in PE, we examine LA and ICP-MS parameters that determine whether the total atom efficiencies for uranium and lead are similar, and explore methods to use the lead content in a plastic as part of the process of estimating or determining the uranium content by LA-ICP-MS.« less

Interferon beta-1b reduces black holes in a randomised trial of clinically isolated syndrome.

PubMed

Nagtegaal, Gijsbert J A; Pohl, Christoph; Wattjes, Mike P; Hulst, Hanneke E; Freedman, Mark S; Hartung, Hans-Peter; Miller, David; Montalban, Xavier; Kappos, Ludwig; Edan, Gilles; Pleimes, Dirk; Beckman, Karola; Stemper, Brigitte; Polman, Christoph H; Sandbrink, Rupert; Barkhof, Frederik

2014-02-01

Multiple sclerosis (MS) is characterised by inflammatory lesions of the central nervous system. Interferon beta-1b (IFNB-1b) has been shown to improve clinical and magnetic resonance imaging (MRI) measures for patients with MS. To evaluate whether IFNB-1b in patients presenting with clinically isolated syndromes (CIS) prevented persisting T1 hypointensities on MRI (persistent black holes (PBHs)). In the placebo-controlled phase, patients (n = 468) were initially randomised to IFNB-1b (n = 292) or placebo (n = 176) for two years or clinically definite MS (CDMS). In the open-label phase (n = 418), both groups were offered IFNB-1b for up to five years. Lesions were classified as PBHs if T1 hypointensity persisted throughout the last available scan (minimum time one year). A total of 435 patients were evaluable for analysis. The number of PBHs/patient was lower in the early rather than the delayed treatment arm during both phases (.42 vs .71, p = .0102 and .70 vs 1.17, p = .0121). Exploratory analyses identified baseline characteristics that affected rate of conversion. Although the rate of lesions that converted to PBH showed no significant differences between groups, the numbers of PBHs per patient out of new lesions was significantly lower in IFNB-1b patients compared to patients on placebo. NCT00544037.

A remarkable adsorbent for removal of contaminants of emerging concern from water: Porous carbon derived from metal azolate framework-6.

PubMed

Bhadra, Biswa Nath; Jhung, Sung Hwa

2017-10-15

A series of metal-azolate frameworks or MAFs-MAF-4, -5, and -6-were synthesized and pyrolyzed to prepare porous carbons derived from MAFs (CDM-4, -5, -6, respectively). Not only the obtained carbons but also MAFs were characterized and applied for the adsorption of organic contaminants of emerging concern (CECs, including pharmaceuticals and personal care products) such as salicylic acid, clofibric acid, diclofenac sodium, bisphenol-A, and oxybenzone (OXB) from water. CDM-6 was found to be the most remarkable adsorbent among the tested ones (including activated carbon) for all the adsorbates. OXB was taken as a representative adsorbate for detailed adsorption studies as well as understanding the adsorption mechanism. H-bonding (H-acceptor: CDM; H-donor: CECs) was suggested as the principal mechanism for the adsorption of tested adsorbates. Finally, CDMs, especially CDM-6, were suggested as highly efficient and easily recyclable adsorbents for water purification. Copyright © 2017 Elsevier B.V. All rights reserved.

Extended maximum likelihood halo-independent analysis of dark matter direct detection data

DOE PAGES

Gelmini, Graciela B.; Georgescu, Andreea; Gondolo, Paolo; ...

2015-11-24

We extend and correct a recently proposed maximum-likelihood halo-independent method to analyze unbinned direct dark matter detection data. Instead of the recoil energy as independent variable we use the minimum speed a dark matter particle must have to impart a given recoil energy to a nucleus. This has the advantage of allowing us to apply the method to any type of target composition and interaction, e.g. with general momentum and velocity dependence, and with elastic or inelastic scattering. We prove the method and provide a rigorous statistical interpretation of the results. As first applications, we find that for dark mattermore » particles with elastic spin-independent interactions and neutron to proton coupling ratio f n/f p=-0.7, the WIMP interpretation of the signal observed by CDMS-II-Si is compatible with the constraints imposed by all other experiments with null results. We also find a similar compatibility for exothermic inelastic spin-independent interactions with f n/f p=-0.8.« less

DAMIC at SNOLAB

DOE PAGES

Chavarria, Alvaro E.; Tiffenberg, Javier; Aguilar-Arevalo, Alexis; ...

2015-03-24

We introduce the fully-depleted charge-coupled device (CCD) as a particle detector. We demonstrate its low energy threshold operation, capable of detecting ionizing energy depositions in a single pixel down to 50 eV ee. We present results of energy calibrations from 0.3 keV ee to 60 ke Vee, showing that the CCD is a fully active detector with uniform energy response throughout the silicon target, good resolution (Fano ~0.16), and remarkable linear response to electron energy depositions. We show the capability of the CCD to localize the depth of particle interactions within the silicon target. We discuss the mode of operationmore » and unique imaging capabilities of the CCD, and how they may be exploited to characterize and suppress backgrounds. We present the first results from the deployment of 250 μm thick CCDs in SNOLAB, a prototype for the upcoming DAMIC100. DAMIC100 will have a target mass of 0.1 kg and should be able to directly test the CDMS-Si signal within a year of operation.« less

Maximum Likelihood Analysis of Low Energy CDMS II Germanium Data

DOE PAGES

Agnese, R.

2015-03-30

We report on the results of a search for a Weakly Interacting Massive Particle (WIMP) signal in low-energy data of the Cryogenic Dark Matter Search experiment using a maximum likelihood analysis. A background model is constructed using GEANT4 to simulate the surface-event background from Pb210decay-chain events, while using independent calibration data to model the gamma background. Fitting this background model to the data results in no statistically significant WIMP component. In addition, we also perform fits using an analytic ad hoc background model proposed by Collar and Fields, who claimed to find a large excess of signal-like events in ourmore » data. Finally, we confirm the strong preference for a signal hypothesis in their analysis under these assumptions, but excesses are observed in both single- and multiple-scatter events, which implies the signal is not caused by WIMPs, but rather reflects the inadequacy of their background model.« less

Development of an open metadata schema for prospective clinical research (openPCR) in China.

PubMed

Xu, W; Guan, Z; Sun, J; Wang, Z; Geng, Y

2014-01-01

In China, deployment of electronic data capture (EDC) and clinical data management system (CDMS) for clinical research (CR) is in its very early stage, and about 90% of clinical studies collected and submitted clinical data manually. This work aims to build an open metadata schema for Prospective Clinical Research (openPCR) in China based on openEHR archetypes, in order to help Chinese researchers easily create specific data entry templates for registration, study design and clinical data collection. Singapore Framework for Dublin Core Application Profiles (DCAP) is used to develop openPCR and four steps such as defining the core functional requirements and deducing the core metadata items, developing archetype models, defining metadata terms and creating archetype records, and finally developing implementation syntax are followed. The core functional requirements are divided into three categories: requirements for research registration, requirements for trial design, and requirements for case report form (CRF). 74 metadata items are identified and their Chinese authority names are created. The minimum metadata set of openPCR includes 3 documents, 6 sections, 26 top level data groups, 32 lower data groups and 74 data elements. The top level container in openPCR is composed of public document, internal document and clinical document archetypes. A hierarchical structure of openPCR is established according to Data Structure of Electronic Health Record Architecture and Data Standard of China (Chinese EHR Standard). Metadata attributes are grouped into six parts: identification, definition, representation, relation, usage guides, and administration. OpenPCR is an open metadata schema based on research registration standards, standards of the Clinical Data Interchange Standards Consortium (CDISC) and Chinese healthcare related standards, and is to be publicly available throughout China. It considers future integration of EHR and CR by adopting data structure and data terms in Chinese EHR Standard. Archetypes in openPCR are modularity models and can be separated, recombined, and reused. The authors recommend that the method to develop openPCR can be referenced by other countries when designing metadata schema of clinical research. In the next steps, openPCR should be used in a number of CR projects to test its applicability and to continuously improve its coverage. Besides, metadata schema for research protocol can be developed to structurize and standardize protocol, and syntactical interoperability of openPCR with other related standards can be considered.

Improving axion detection sensitivity in high purity germanium detector based experiments

NASA Astrophysics Data System (ADS)

Xu, Wenqin; Elliott, Steven

2015-04-01

Thanks to their excellent energy resolution and low energy threshold, high purity germanium (HPGe) crystals are widely used in low background experiments searching for neutrinoless double beta decay, e.g. the MAJORANA DEMONSTRATOR and the GERDA experiments, and low mass dark matter, e.g. the CDMS and the EDELWEISS experiments. A particularly interesting candidate for low mass dark matter is the axion, which arises from the Peccei-Quinn solution to the strong CP problem and has been searched for in many experiments. Due to axion-photon coupling, the postulated solar axions could coherently convert to photons via the Primakeoff effect in periodic crystal lattices, such as those found in HPGe crystals. The conversion rate depends on the angle between axions and crystal lattices, so the knowledge of HPGe crystal axis is important. In this talk, we will present our efforts to improve the HPGe experimental sensitivity to axions by considering the axis orientations in multiple HPGe crystals simultaneously. We acknowledge the support of the U.S. Department of Energy through the LANL/LDRD Program.

US Cosmic Visions: New Ideas in Dark Matter 2017 : Community Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Feng, J.; Fox, P.; Dawson, W. A.

This white paper summarizes the workshop “U.S. Cosmic Visions: New Ideas in Dark Matter” held at University of Maryland from March 23-25. The flagships of the US Dark Matter search program are the G2 experiments ADMX, LZ, and SuperCDMS, which will cover well-motivated axion and WIMP dark matter over a range of masses. The workshop assumes that a complete exploration of this parameter space remains the highest priority of the dark matter community, and focuses instead on the science case for additional new small-scale projects in dark matter science that complement the G2 program (and other ongoing projects worldwide). Itmore » therefore concentrates on exploring distinct, well-motivated parameter space that will not be covered by the existing program; on surveying ideas for such projects (i.e. projects costing ~$10M or less); and on placing these ideas in a global context. The workshop included over 100 presentations of new ideas, proposals and recent science and R&D results from the US and international scientific community.« less

Direct detection signatures of self-interacting dark matter with a light mediator

DOE PAGES

Nobile, Eugenio Del; Kaplinghat, Manoj; Yu, Hai-Bo

2015-10-27

Self-interacting dark matter (SIDM) is a simple and well-motivated scenario that could explain long-standing puzzles in structure formation on small scales. If the required self-interaction arises through a light mediator (with mass ~ 10 MeV) in the dark sector, this new particle must be unstable to avoid overclosing the universe. The decay of the light mediator could happen due to a weak coupling of the hidden and visible sectors, providing new signatures for direct detection experiments. The SIDM nuclear recoil spectrum is more peaked towards low energies compared to the usual case of contact interactions, because the mediator mass ismore » comparable to the momentum transfer of nuclear recoils. We show that the SIDM signal could be distinguished from that of DM particles with contact interactions by considering the time-average energy spectrum in experiments employing different target materials, or the average and modulated spectra in a single experiment. Using current limits from LUX and SuperCDMS, we also derive strong bounds on the mixing parameter between hidden and visible sector.« less

Systematic development and optimization of chemically defined medium supporting high cell density growth of Bacillus coagulans.

PubMed

Chen, Yu; Dong, Fengqing; Wang, Yonghong

2016-09-01

With determined components and experimental reducibility, the chemically defined medium (CDM) and the minimal chemically defined medium (MCDM) are used in many metabolism and regulation studies. This research aimed to develop the chemically defined medium supporting high cell density growth of Bacillus coagulans, which is a promising producer of lactic acid and other bio-chemicals. In this study, a systematic methodology combining the experimental technique with flux balance analysis (FBA) was proposed to design and simplify a CDM. The single omission technique and single addition technique were employed to determine the essential and stimulatory compounds, before the optimization of their concentrations by the statistical method. In addition, to improve the growth rationally, in silico omission and addition were performed by FBA based on the construction of a medium-size metabolic model of B. coagulans 36D1. Thus, CDMs were developed to obtain considerable biomass production of at least five B. coagulans strains, in which two model strains B. coagulans 36D1 and ATCC 7050 were involved.

Taking Halo-Independent Dark Matter Methods Out of the Bin

DOE PAGES

Fox, Patrick J.; Kahn, Yonatan; McCullough, Matthew

2014-10-30

We develop a new halo-independent strategy for analyzing emerging DM hints, utilizing the method of extended maximum likelihood. This approach does not require the binning of events, making it uniquely suited to the analysis of emerging DM direct detection hints. It determines a preferred envelope, at a given confidence level, for the DM velocity integral which best fits the data using all available information and can be used even in the case of a single anomalous scattering event. All of the halo-independent information from a direct detection result may then be presented in a single plot, allowing simple comparisons betweenmore » multiple experiments. This results in the halo-independent analogue of the usual mass and cross-section plots found in typical direct detection analyses, where limit curves may be compared with best-fit regions in halo-space. The method is straightforward to implement, using already-established techniques, and its utility is demonstrated through the first unbinned halo-independent comparison of the three anomalous events observed in the CDMS-Si detector with recent limits from the LUX experiment.« less

Spontaneous Mass and Charge Losses from Single Multi-Megadalton Ions Studied by Charge Detection Mass Spectrometry

NASA Astrophysics Data System (ADS)

Keifer, David Z.; Alexander, Andrew W.; Jarrold, Martin F.

2017-03-01

Spontaneous mass and charge losses from individual multi-megadalton ions have been observed with charge detection mass spectrometry (CDMS) by trapping single hepatitis B virus (HBV) capsids for 3 s. Gradual increases in the oscillation frequency of single ions in the ion trap are attributed mainly to mass loss (probably solvent, water, and/or salt). The total mass lost during the 3 s trapping period peaks at around 20 kDa for 4 MDa HBV T = 4 capsids. Discrete frequency drops punctuate the gradual increases in the oscillation frequencies. The drops are attributed to a sudden loss of charge. In most cases a single positive charge is lost along with some mass (on average around 1000 Da). Charge loss occurs for over 40% of the trapped ions. It usually occurs near the beginning of the trapping event, and it occurs preferentially in regions of the trap with strong electric fields, indicating that external electric fields promote charge loss. This process may contribute to the decrease in m/ z resolution that often occurs with megadalton ions.

Development of a TES-Based Anti-Coincidence Detector for Future X-Ray Observations

NASA Technical Reports Server (NTRS)

Bailey, Catherine N.; Adams, J. S.; Bandler, S. R.; Eckart, M. E.; Ewin, A. J.; Finkbeiner, F. M.; Kelley, R. L.; Kilbourne, C. A.; Porter, F. S.; Sadleir, J. E.;

Development of a TES-Based Anti-Coincidence Detector for Future X-ray Observatories

NASA Technical Reports Server (NTRS)

Bailey, Catherine

2011-01-01

Microcalorimeters onboard future x-ray observatories require an anti-coincidence detector to remove environmental backgrounds. In order to most effectively integrate this anticoincidence detector with the main microcalorimeter array, both instruments should use similar read-out technology. The detectors used in the Cryogenic Dark Matter Search (CDMS) use a phonon measurement technique that is well suited for an anti-coincidence detector with a microcalorimeter array using SQUID readout. This technique works by using a transition-edge sensor (TES) connected to superconducting collection fins to measure the athermal phonon signal produced when an event occurs in the substrate crystal. Energy from the event propagates through the crystal to the superconducting collection fins, creating quasiparticles, which are then trapped as they enter the TES where they produce a signal. We are currently developing a prototype anti-coincidence detector for future x-ray missions and have recently fabricated test devices with Mo/Au TESs and Al collection fins. We will present results from the first tests of these devices which indicate a proof of concept that quasiparticle trapping is occurring in these materials.

Extending the Fermi-LAT Data Processing Pipeline to the Grid

NASA Astrophysics Data System (ADS)

Zimmer, S.; Arrabito, L.; Glanzman, T.; Johnson, T.; Lavalley, C.; Tsaregorodtsev, A.

2012-12-01

The Data Handling Pipeline (“Pipeline”) has been developed for the Fermi Gamma-Ray Space Telescope (Fermi) Large Area Telescope (LAT) which launched in June 2008. Since then it has been in use to completely automate the production of data quality monitoring quantities, reconstruction and routine analysis of all data received from the satellite and to deliver science products to the collaboration and the Fermi Science Support Center. Aside from the reconstruction of raw data from the satellite (Level 1), data reprocessing and various event-level analyses are also reasonably heavy loads on the pipeline and computing resources. These other loads, unlike Level 1, can run continuously for weeks or months at a time. In addition it receives heavy use in performing production Monte Carlo tasks. In daily use it receives a new data download every 3 hours and launches about 2000 jobs to process each download, typically completing the processing of the data before the next download arrives. The need for manual intervention has been reduced to less than 0.01% of submitted jobs. The Pipeline software is written almost entirely in Java and comprises several modules. The software comprises web-services that allow online monitoring and provides charts summarizing work flow aspects and performance information. The server supports communication with several batch systems such as LSF and BQS and recently also Sun Grid Engine and Condor. This is accomplished through dedicated job control services that for Fermi are running at SLAC and the other computing site involved in this large scale framework, the Lyon computing center of IN2P3. While being different in the logic of a task, we evaluate a separate interface to the Dirac system in order to communicate with EGI sites to utilize Grid resources, using dedicated Grid optimized systems rather than developing our own. More recently the Pipeline and its associated data catalog have been generalized for use by other experiments, and are currently being used by the Enriched Xenon Observatory (EXO), Cryogenic Dark Matter Search (CDMS) experiments as well as for Monte Carlo simulations for the future Cherenkov Telescope Array (CTA).

eXtended CASA Line Analysis Software Suite (XCLASS)

NASA Astrophysics Data System (ADS)

Möller, T.; Endres, C.; Schilke, P.

2017-02-01

The eXtended CASA Line Analysis Software Suite (XCLASS) is a toolbox for the Common Astronomy Software Applications package (CASA) containing new functions for modeling interferometric and single dish data. Among the tools is the myXCLASS program which calculates synthetic spectra by solving the radiative transfer equation for an isothermal object in one dimension, whereas the finite source size and dust attenuation are considered as well. Molecular data required by the myXCLASS program are taken from an embedded SQLite3 database containing entries from the Cologne Database for Molecular Spectroscopy (CDMS) and JPL using the Virtual Atomic and Molecular Data Center (VAMDC) portal. Additionally, the toolbox provides an interface for the model optimizer package Modeling and Analysis Generic Interface for eXternal numerical codes (MAGIX), which helps to find the best description of observational data using myXCLASS (or another external model program), that is, finding the parameter set that most closely reproduces the data. http://www.astro.uni-koeln.de/projects/schilke/myXCLASSInterface A copy of the code is available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/598/A7

A financing model to solve financial barriers for implementing green building projects.

PubMed

Lee, Sanghyo; Lee, Baekrae; Kim, Juhyung; Kim, Jaejun

2013-01-01

Along with the growing interest in greenhouse gas reduction, the effect of greenhouse gas energy reduction from implementing green buildings is gaining attention. The government of the Republic of Korea has set green growth as its paradigm for national development, and there is a growing interest in energy saving for green buildings. However, green buildings may have financial barriers that have high initial construction costs and uncertainties about future project value. Under the circumstances, governmental support to attract private funding is necessary to implement green building projects. The objective of this study is to suggest a financing model for facilitating green building projects with a governmental guarantee based on Certified Emission Reduction (CER). In this model, the government provides a guarantee for the increased costs of a green building project in return for CER. And this study presents the validation of the model as well as feasibility for implementing green building project. In addition, the suggested model assumed governmental guarantees for the increased cost, but private guarantees seem to be feasible as well because of the promising value of the guarantee from CER. To do this, certification of Clean Development Mechanisms (CDMs) for green buildings must be obtained.

A Financing Model to Solve Financial Barriers for Implementing Green Building Projects

PubMed Central

Lee, Baekrae; Kim, Juhyung; Kim, Jaejun

2013-01-01

Along with the growing interest in greenhouse gas reduction, the effect of greenhouse gas energy reduction from implementing green buildings is gaining attention. The government of the Republic of Korea has set green growth as its paradigm for national development, and there is a growing interest in energy saving for green buildings. However, green buildings may have financial barriers that have high initial construction costs and uncertainties about future project value. Under the circumstances, governmental support to attract private funding is necessary to implement green building projects. The objective of this study is to suggest a financing model for facilitating green building projects with a governmental guarantee based on Certified Emission Reduction (CER). In this model, the government provides a guarantee for the increased costs of a green building project in return for CER. And this study presents the validation of the model as well as feasibility for implementing green building project. In addition, the suggested model assumed governmental guarantees for the increased cost, but private guarantees seem to be feasible as well because of the promising value of the guarantee from CER. To do this, certification of Clean Development Mechanisms (CDMs) for green buildings must be obtained. PMID:24376379

Multiple Sclerosis and Subsequent Human Immunodeficiency Virus Infection: A Case with the Rare Comorbidity, Focus on Novel Treatment Issues and Review of the Literature.

PubMed

Skarlis, Charalampos; Gontika, Maria; Katsavos, Serafeim; Velonakis, Giorgios; Toulas, Panagiotis; Anagnostouli, Maria

2017-01-01

The comorbidity between Multiple Sclerosis (MS) and Human Immunodeficiency Virus (HIV) infection is particularly rare. Only a few cases of comorbidity of Clinically Definite(CD)-MS and HIV have been documented worldwide, while the potential beneficial role of antiretroviral therapy regarding MS activity has long been an area of debate. We present a 36-year old male, bearing a diagnosis of CD-MS for twelve years. He had been treated for ten years with interferon-beta-1b, when he voluntarily discontinued therapy, claiming clinical stability. One year later he was diagnosed positive for HIV and he started and continued only on efavirenz/emricitabine/tenofovir-disoproxil fumarate (ATRIPLA®), remaining relapse-free until today. This fact, in combination with the unique pharmaceutical composition of the drug, which contains a component similar to a newly-approved agent for MS, dimethyl fumarate, prompted us to review the literature regarding this rare comorbidity and to suggest that the role of the antiretroviral therapy should be further explored in MS. Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Dark matter, proton decay and other phenomenological constraints in F-SU(5)

NASA Astrophysics Data System (ADS)

Li, Tianjun; Maxin, James A.; Nanopoulos, Dimitri V.; Walker, Joel W.

2011-07-01

We study gravity mediated supersymmetry breaking in F-SU(5) and its low-energy supersymmetric phenomenology. The gaugino masses are not unified at the traditional grand unification scale, but we nonetheless have the same one-loop gaugino mass relation at the electroweak scale as minimal supergravity (mSUGRA). We introduce parameters testable at the colliders to measure the small second loop deviation from the mSUGRA gaugino mass relation at the electroweak scale. In the minimal SU(5) model with gravity mediated supersymmetry breaking, we show that the deviations from the mSUGRA gaugino mass relations are within 5%. However, in F-SU(5), we predict the deviations from the mSUGRA gaugino mass relations to be larger due to the presence of vector-like particles, which can be tested at the colliders. We determine the viable parameter space that satisfies all the latest experimental constraints and find it is consistent with the CDMS II experiment. Further, we compute the cross-sections of neutralino annihilations into gamma-rays and compare to the first published Fermi-LAT measurement. Finally, the corresponding range of proton lifetime predictions is calculated and found to be within reach of the future Hyper-Kamiokande and DUSEL experiments.

Atomic and Molecular Databases, VAMDC (Virtual Atomic and Molecular Data Centre)

NASA Astrophysics Data System (ADS)

Dubernet, Marie-Lise; Zwölf, Carlo Maria; Moreau, Nicolas; Awa Ba, Yaya; VAMDC Consortium

2015-08-01

The "Virtual Atomic and Molecular Data Centre Consortium",(VAMDC Consortium, http://www.vamdc.eu) is a Consortium bound by an Memorandum of Understanding aiming at ensuring the sustainability of the VAMDC e-infrastructure. The current VAMDC e-infrastructure inter-connects about 30 atomic and molecular databases with the number of connected databases increasing every year: some databases are well-known databases such as CDMS, JPL, HITRAN, VALD,.., other databases have been created since the start of VAMDC. About 90% of our databases are used for astrophysical applications. The data can be queried, retrieved, visualized in a single format from a general portal (http://portal.vamdc.eu) and VAMDC is also developing standalone tools in order to retrieve and handle the data. VAMDC provides software and support in order to include databases within the VAMDC e-infrastructure. One current feature of VAMDC is the constrained environnement of description of data that ensures a higher quality for distribution of data; a future feature is the link of VAMDC with evaluation/validation groups. The talk will present the VAMDC Consortium and the VAMDC e infrastructure with its underlying technology, its services, its science use cases and its etension towards other communities than the academic research community.

Annual modulation experiments, galactic models and WIMPs

NASA Astrophysics Data System (ADS)

Hudson, Robert G.

Our task in the paper is to examine some recent experiments (in the period 1996-2002) bearing on the issue of whether there is dark matter in the universe in the form of neutralino WIMPs (weakly interacting massive particles). Our main focus is an experiment performed by the DAMA group that claims to have found an 'annual modulation signature' for the WIMP. DAMA's result has been hotly contested by two other groups, EDELWEISS and CDMS, and we study the details of the experiments performed by all three groups. Our goal is to investigate the philosophic and sociological implications of this controversy. Particularly, using an innovative theoretical strategy suggested by (Copi, C. and L. M. Krauss (2003). Comparing interaction rate detectors for weakly interacting massive particles with annual modulation detectors. Physical Review D, 67, 103 507), we suggest a new way of resolving discordant experimental data (extending a previous analysis by (Franklin, A. (2002). Selectivity and discord. Pittsburgh: University of Pittsburgh Press). In addition, we are in a position to contribute substantively to the debate between realists and constructive empiricists. Finally, from a sociological standpoint, we remark that DAMA's work has been valuable in mobilizing other research teams and providing them with a critical focus.

Inelastic dark matter in light of DAMA/LIBRA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chang, Spencer; Weiner, Neal; Kribs, Graham D.

2009-02-15

Inelastic dark matter, in which weakly interacting massive particle (WIMP)-nucleus scatterings occur through a transition to an excited WIMP state {approx}100 keV above the ground state, provides a compelling explanation of the DAMA annual modulation signal. We demonstrate that the relative sensitivities of various dark matter direct detection experiments are modified such that the DAMA annual modulation signal can be reconciled with the absence of a reported signal at CDMS-Soudan, XENON10, ZEPLIN, CRESST, and KIMS for inelastic WIMPs with masses O(100 GeV). We review the status of these experiments, and make predictions for upcoming ones. In particular, we note thatmore » inelastic dark matter leads to highly suppressed signals at low energy, with most events typically occurring between 20 and 45 keV (unquenched) at xenon and iodine experiments, and generally no events at low ({approx}10 keV) energies. Suppressing the background in this high-energy region is essential to testing this scenario. The recent CRESST data suggest seven observed tungsten events, which is consistent with expectations from this model. If the tungsten signal persists at future CRESST runs, it would provide compelling evidence for inelastic dark matter, while its absence should exclude it.« less

The ISS Fluids Integrated Rack (FIR): a Summary of Capabilities

NASA Astrophysics Data System (ADS)

Gati, F.; Hill, M. E.

2002-01-01

The Fluids Integrated Rack (FIR) is a modular, multi-user scientific research facility that will fly in the U.S. laboratory module, Destiny, of the International Space Station (ISS). The FIR will be one of the two racks that will make up the Fluids and Combustion Facility (FCF) - the other being the Combustion Integrated Rack (CIR). The ISS will provide the FCF with the necessary resources, such as power and cooling. While the ISS crew will be available for experiment operations, their time will be limited. The FCF is, therefore, being designed for autonomous operations and remote control operations. Control of the FCF will be primarily through the Telescience Support Center (TSC) at the Glenn Research Center. The FCF is being designed to accommodate a wide range of combustion and fluids physics experiments within the ISS resources and constraints. The primary mission of the FIR, however, is to accommodate experiments from four major fluids physics disciplines: Complex Fluids; Multiphase Flow and Heat Transfer; Interfacial Phenomena; and Dynamics and Stability. The design of the FIR is flexible enough to accommodate experiments from other science disciplines such as Biotechnology. The FIR flexibility is a result of the large volume dedicated for experimental hardware, easily re-configurable diagnostics that allow for unique experiment configurations, and it's customizable software. The FIR will utilize six major subsystems to accommodate this broad scope of fluids physics experiments. The major subsystems are: structural, environmental, electrical, gaseous, command and data management, and imagers and illumination. Within the rack, the FIR's structural subsystem provides an optics bench type mechanical interface for the precise mounting of experimental hardware; including optical components. The back of the bench is populated with FIR avionics packages and light sources. The interior of the rack is isolated from the cabin through two rack doors that are hinged near the top and bottom of the rack. Transmission of micro-gravity disturbances to and from the rack is minimized through the Active Rack Isolation System (ARIS). The environmental subsystem will utilize air and water to remove heat generated by facility and experimental hardware. The air will be circulated throughout the rack and will be cooled by an air-water heat exchanger. Water will be used directly to cool some of the FIR components and will also be available to cool experiment hardware as required. The electrical subsystem includes the Electrical Power Control Unit (EPCU), which provides 28 VDC and 120 VDC power to the facility and the experiment hardware. The EPCU will also provide power management and control functions, as well as fault protection capabilities. The FIR will provide access to the ISS gaseous nitrogen and vacuum systems. These systems are available to support experiment operations such as the purging of experimental cells, creating flows within experimental cells and providing dry conditions where needed. The FIR Command and Data Management subsystem (CDMS) provides command and data handling for both facility and experiment hardware. The Input Output Processor (IOP) provides the overall command and data management functions for the rack including downlinking or writing data to removable drives. The IOP will also monitor the health and status of the rack subsystems. The Image Processing and Storage Units (IPSU) will perform diagnostic control and image data acquisition functions. An IPSU will be able to control a digital camera, receive image data from that camera and process/ compress image data as necessary. The Fluids Science and Avionics Package (FSAP) will provide the primary control over an experiment. The FSAP contains various computer boards/cards that will perform data and control functions. To support the imaging needs, cameras and illumination sources will be available to the investigator. Both color analog and black and white digital cameras with lenses are expected. These cameras will be capable of high resolution and, separately, frame rates up to 32,000 frames per second. Lenses for these cameras will provide both microscopic and macroscopic views. The FIR will provide two illumination sources, a 532 nm Nd:YAG laser and a white light source, both with adjustable power output. The FIR systems are being designed to maximize the amount of science that can be done on-orbit. Experiments will be designed and efficiently operated. Each individual experiment must determine the best configuration of utilizing facility capabilities and resources with augmentation of specific experiment hardware. Efficient operations will be accomplished via a combination of on-orbit physical component change-outs or processing by the crew, and software updates via ground commanding or by the crew. Careful coordination by ground and on-orbit personnel regarding the on-orbit storage and downlinking of image data will also be very important.

Toward single electron resolution phonon mediated ionization detectors

NASA Astrophysics Data System (ADS)

Mirabolfathi, Nader; Harris, H. Rusty; Mahapatra, Rupak; Sundqvist, Kyle; Jastram, Andrew; Serfass, Bruno; Faiez, Dana; Sadoulet, Bernard

2017-05-01

Experiments seeking to detect rare event interactions such as dark matter or coherent elastic neutrino nucleus scattering are striving for large mass detectors with very low detection threshold. Using Neganov-Luke phonon amplification effect, the Cryogenic Dark Matter Search (CDMS) experiment is reaching unprecedented RMS resolutions of ∼14 eVee. CDMSlite is currently the most sensitive experiment to WIMPs of mass ∼5 GeV/c2 but is limited in achieving higher phonon gains due to an early onset of leakage current into Ge crystals. The contact interface geometry is particularly weak for blocking hole injection from the metal, and thus a new design is demonstrated that allows high voltage bias via vacuum separated electrode. With an increased bias voltage and a×2 Luke phonon gain, world best RMS resolution of sigma ∼7 eVee for 0.25 kg (d=75 mm, h=1 cm) Ge detectors was achieved. Since the leakage current is a function of the field and the phonon gain is a function of the applied voltage, appropriately robust interface blocking material combined with thicker substrate (25 mm) will reach a resolution of ∼2.8 eVee. In order to achieve better resolution of ∼ eV, we are investigating a layer of insulator between the phonon readout surface and the semiconductor crystals.

Status of the scalar singlet dark matter model

NASA Astrophysics Data System (ADS)

Athron, Peter; Balázs, Csaba; Bringmann, Torsten; Buckley, Andy; Chrząszcz, Marcin; Conrad, Jan; Cornell, Jonathan M.; Dal, Lars A.; Edsjö, Joakim; Farmer, Ben; Jackson, Paul; Kahlhoefer, Felix; Krislock, Abram; Kvellestad, Anders; McKay, James; Mahmoudi, Farvah; Martinez, Gregory D.; Putze, Antje; Raklev, Are; Rogan, Christopher; Saavedra, Aldo; Savage, Christopher; Scott, Pat; Serra, Nicola; Weniger, Christoph; White, Martin

2017-08-01

One of the simplest viable models for dark matter is an additional neutral scalar, stabilised by a Z_2 symmetry. Using the GAMBIT package and combining results from four independent samplers, we present Bayesian and frequentist global fits of this model. We vary the singlet mass and coupling along with 13 nuisance parameters, including nuclear uncertainties relevant for direct detection, the local dark matter density, and selected quark masses and couplings. We include the dark matter relic density measured by Planck, direct searches with LUX, PandaX, SuperCDMS and XENON100, limits on invisible Higgs decays from the Large Hadron Collider, searches for high-energy neutrinos from dark matter annihilation in the Sun with IceCube, and searches for gamma rays from annihilation in dwarf galaxies with the Fermi-LAT. Viable solutions remain at couplings of order unity, for singlet masses between the Higgs mass and about 300 GeV, and at masses above ˜ 1 TeV. Only in the latter case can the scalar singlet constitute all of dark matter. Frequentist analysis shows that the low-mass resonance region, where the singlet is about half the mass of the Higgs, can also account for all of dark matter, and remains viable. However, Bayesian considerations show this region to be rather fine-tuned.

Exothermic double-disk dark matter

DOE Office of Scientific and Technical Information (OSTI.GOV)

McCullough, Matthew; Randall, Lisa, E-mail: mccull@mit.edu, E-mail: randall@physics.harvard.edu

2013-10-01

If a subdominant component of dark matter (DM) interacts via long-range dark force carriers it may cool and collapse to form complex structures within the Milky Way galaxy, such as a rotating dark disk. This scenario was proposed recently and termed ''Double-Disk Dark Matter'' (DDDM). In this paper we consider the possibility that DDDM remains in a cosmologically long-lived excited state and can scatter exothermically on nuclei (ExoDDDM). We investigate the current status of ExoDDDM direct detection and find that ExoDDDM can readily explain the recently announced ∼ 3σ excess observed at CDMS-Si, with almost all of the 90% best-fitmore » parameter space in complete consistency with limits from other experiments, including XENON10 and XENON100. In the absence of isospin-dependent couplings, this consistency requires light DM with mass typically in the 5-15 GeV range. The hypothesis of ExoDDDM can be tested in direct detection experiments through its peaked recoil spectra, reduced annual modulation amplitude, and, in some cases, its novel time-dependence. We also discuss future direct detection prospects and additional indirect constraints from colliders and solar capture of ExoDDDM. As theoretical proof-of-principle, we combine the features of exothermic DM models and DDDM models to construct a complete model of ExoDDDM, exhibiting all the required properties.« less

Highly Accurate Potential Energy Surface, Dipole Moment Surface, Rovibrational Energy Levels, and Infrared Line List for (32)S(16)O2 up to 8000 cm(exp -1)

NASA Technical Reports Server (NTRS)

Huang, Xinchuan; Schwenke, David W.; Lee, Timothy J.

2014-01-01

A purely ab initio potential energy surface (PES) was refined with selected (32)S(16)O2 HITRAN data. Compared to HITRAN, the root-mean-squares error (RMS) error for all J=0-80 rovibrational energy levels computed on the refined PES (denoted Ames-1) is 0.013 cm(exp -1). Combined with a CCSD(T)/aug-cc-pV(Q+d)Z dipole moment surface (DMS), an infrared (IR) line list (denoted Ames-296K) has been computed at 296K and covers up to 8,000 cm(exp -1). Compared to the HITRAN and CDMS databases, the intensity agreement for most vibrational bands is better than 85-90%. Our predictions for (34)S(16)O2 band origins, higher energy (32)S(16)O2 band origins and missing (32)S(16)O2 IR bands have been verified by most recent experiments and available HITRAN data. We conclude that the Ames-1 PES is able to predict (32/34)S(16)O2 band origins below 5500 cm(exp -1) with 0.01-0.03 cm(exp -1) uncertainties, and the Ames-296K line list provides continuous, reliable and accurate IR simulations. The Ka-dependence of both line position and line intensity errors is discussed. The line list will greatly facilitate SO2 IR spectral experimental analysis, as well as elimination of SO2 lines in high-resolution astronomical observations.

Low-mass dark matter search with CDMSlite

NASA Astrophysics Data System (ADS)

Agnese, R.; Anderson, A. J.; Aralis, T.; Aramaki, T.; Arnquist, I. J.; Baker, W.; Balakishiyeva, D.; Barker, D.; Basu Thakur, R.; Bauer, D. A.; Binder, T.; Bowles, M. A.; Brink, P. L.; Bunker, R.; Cabrera, B.; Caldwell, D. O.; Calkins, R.; Cartaro, C.; Cerdeño, D. G.; Chang, Y.; Chagani, H.; Chen, Y.; Cooley, J.; Cornell, B.; Cushman, P.; Daal, M.; Di Stefano, P. C. F.; Doughty, T.; Esteban, L.; Fascione, E.; Figueroa-Feliciano, E.; Fritts, M.; Gerbier, G.; Ghaith, M.; Godfrey, G. L.; Golwala, S. R.; Hall, J.; Harris, H. R.; Hong, Z.; Hoppe, E. W.; Hsu, L.; Huber, M. E.; Iyer, V.; Jardin, D.; Jastram, A.; Jena, C.; Kelsey, M. H.; Kennedy, A.; Kubik, A.; Kurinsky, N. A.; Leder, A.; Loer, B.; Lopez Asamar, E.; Lukens, P.; MacDonell, D.; Mahapatra, R.; Mandic, V.; Mast, N.; Miller, E. H.; Mirabolfathi, N.; Moffatt, R. A.; Mohanty, B.; Morales Mendoza, J. D.; Nelson, J.; Orrell, J. L.; Oser, S. M.; Page, K.; Page, W. A.; Partridge, R.; Pepin, M.; Peñalver Martinez, M.; Phipps, A.; Poudel, S.; Pyle, M.; Qiu, H.; Rau, W.; Redl, P.; Reisetter, A.; Reynolds, T.; Roberts, A.; Robinson, A. E.; Rogers, H. E.; Saab, T.; Sadoulet, B.; Sander, J.; Schneck, K.; Schnee, R. W.; Scorza, S.; Senapati, K.; Serfass, B.; Speller, D.; Stein, M.; Street, J.; Tanaka, H. A.; Toback, D.; Underwood, R.; Villano, A. N.; von Krosigk, B.; Welliver, B.; Wilson, J. S.; Wilson, M. J.; Wright, D. H.; Yellin, S.; Yen, J. J.; Young, B. A.; Zhang, X.; Zhao, X.; SuperCDMS Collaboration

2018-01-01

The SuperCDMS experiment is designed to directly detect weakly interacting massive particles (WIMPs) that may constitute the dark matter in our Galaxy. During its operation at the Soudan Underground Laboratory, germanium detectors were run in the CDMSlite mode to gather data sets with sensitivity specifically for WIMPs with masses <10 GeV /c2 . In this mode, a higher detector-bias voltage is applied to amplify the phonon signals produced by drifting charges. This paper presents studies of the experimental noise and its effect on the achievable energy threshold, which is demonstrated to be as low as 56 eVee (electron equivalent energy). The detector-biasing configuration is described in detail, with analysis corrections for voltage variations to the level of a few percent. Detailed studies of the electric-field geometry, and the resulting successful development of a fiducial parameter, eliminate poorly measured events, yielding an energy resolution ranging from ˜9 eVee at 0 keV to 101 eVee at ˜10 keVee . New results are derived for astrophysical uncertainties relevant to the WIMP-search limits, specifically examining how they are affected by variations in the most probable WIMP velocity and the Galactic escape velocity. These variations become more important for WIMP masses below 10 GeV /c2 . Finally, new limits on spin-dependent low-mass WIMP-nucleon interactions are derived, with new parameter space excluded for WIMP masses ≲3 GeV /c2.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Agnese, R.; Anderson, A. J.; Aralis, T.

The SuperCDMS experiment is designed to directly detect weakly interacting massive particles (WIMPs) that may constitute the dark matter in our Galaxy. During its operation at the Soudan Underground Laboratory, germanium detectors were run in the CDMSlite mode to gather data sets with sensitivity specifically for WIMPs with masses < 10 GeV/c 2. In this mode, a higher detector-bias voltage is applied to amplify the phonon signals produced by drifting charges. This article presents studies of the experimental noise and its effect on the achievable energy threshold, which is demonstrated to be as low as 56 eV ee (electron equivalentmore » energy). The detector-biasing configuration is described in detail, with analysis corrections for voltage variations to the level of a few percent. Detailed studies of the electric-field geometry, and the resulting successful development of a fiducial parameter, eliminate poorly measured events, yielding an energy resolution ranging from ~ 9 eV ee at 0 keV to 101 eV ee at ~ 10 keV ee. New results are derived for astrophysical uncertainties relevant to the WIMP-search limits, specifically examining how they are affected by variations in the most probable WIMP velocity and the Galactic escape velocity. These variations become more important for WIMP masses below 10 GeV/c 2. Finally, new limits on spin-dependent low-mass WIMP-nucleon interactions are derived, with new parameter space excluded for WIMP masses ≲ 3 GeV/c 2.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Agnese, R.; Anderson, A. J.; Aralis, T.

The SuperCDMS experiment is designed to directly detect WIMPs (Weakly Interacting Massive Particles) that may constitute the dark matter in our galaxy. During its operation at the Soudan Underground Laboratory, germanium detectors were run in the CDMSlite (Cryogenic Dark Matter Search low ionization threshold experiment) mode to gather data sets with sensitivity specifically for WIMPs with massesmore » $${<}10$$ GeV/$c^2$. In this mode, a large detector-bias voltage is applied to amplify the phonon signals produced by drifting charges. This paper presents studies of the experimental noise and its effect on the achievable energy threshold, which is demonstrated to be as low as 56 eV$$_{\\text{ee}}$$ (electron equivalent energy). The detector biasing configuration is described in detail, with analysis corrections for voltage variations to the level of a few percent. Detailed studies of the electric-field geometry, and the resulting successful development of a fiducial parameter, eliminate poorly measured events, yielding an energy resolution ranging from $${\\sim}$$9 eV$$_{\\text{ee}}$$ at 0 keV to 101 eV$$_{\\text{ee}}$$ at $${\\sim}$$10 keV$$_{\\text{ee}}$$. New results are derived for astrophysical uncertainties relevant to the WIMP-search limits, specifically examining how they are affected by variations in the most probable WIMP velocity and the galactic escape velocity. These variations become more important for WIMP masses below 10 GeV/$c^2$. Finally, new limits on spin-dependent low-mass WIMP-nucleon interactions are derived, with new parameter space excluded for WIMP masses $${\\lesssim}$$3 GeV/$c^2$.« less

New method for analyzing dark matter direct detection data

NASA Astrophysics Data System (ADS)

Davis, Jonathan H.; Enßlin, Torsten; BÅ`hm, Céline

2014-02-01

The experimental situation of dark matter direct detection has reached an exciting crossroads, with potential hints of a discovery of dark matter (DM) from the CDMS, CoGeNT, CRESST-II and DAMA experiments in tension with null results from xenon-based experiments such as XENON100 and LUX. Given the present controversial experimental status, it is important that the analytical method used to search for DM in direct detection experiments is both robust and flexible enough to deal with data for which the distinction between signal and background points is difficult, and hence where the choice between setting a limit or defining a discovery region is debatable. In this article we propose a novel (Bayesian) analytical method, which can be applied to all direct detection experiments and which extracts the maximum amount of information from the data. We apply our method to the XENON100 experiment data as a worked example, and show that firstly our exclusion limit at 90% confidence is in agreement with their own for the 225 live days data, but is several times stronger for the 100 live days data. Secondly we find that, due to the two points at low values of S1 and S2 in the 225 days data set, our analysis points to either weak consistency with low-mass dark matter or the possible presence of an unknown background. Given the null result from LUX, the latter scenario seems the more plausible.

Low-mass dark matter search with CDMSlite

DOE PAGES

Agnese, R.; Anderson, A. J.; Aralis, T.; ...

2018-01-17

The SuperCDMS experiment is designed to directly detect weakly interacting massive particles (WIMPs) that may constitute the dark matter in our Galaxy. During its operation at the Soudan Underground Laboratory, germanium detectors were run in the CDMSlite mode to gather data sets with sensitivity specifically for WIMPs with masses < 10 GeV/c 2. In this mode, a higher detector-bias voltage is applied to amplify the phonon signals produced by drifting charges. This article presents studies of the experimental noise and its effect on the achievable energy threshold, which is demonstrated to be as low as 56 eV ee (electron equivalentmore » energy). The detector-biasing configuration is described in detail, with analysis corrections for voltage variations to the level of a few percent. Detailed studies of the electric-field geometry, and the resulting successful development of a fiducial parameter, eliminate poorly measured events, yielding an energy resolution ranging from ~ 9 eV ee at 0 keV to 101 eV ee at ~ 10 keV ee. New results are derived for astrophysical uncertainties relevant to the WIMP-search limits, specifically examining how they are affected by variations in the most probable WIMP velocity and the Galactic escape velocity. These variations become more important for WIMP masses below 10 GeV/c 2. Finally, new limits on spin-dependent low-mass WIMP-nucleon interactions are derived, with new parameter space excluded for WIMP masses ≲ 3 GeV/c 2.« less

5 CFR 430.304 - SES performance management systems.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false SES performance management systems. 430... PERFORMANCE MANAGEMENT Managing Senior Executive Performance § 430.304 SES performance management systems. (a... or more performance management systems for its senior executives. (b) Performance management systems...

5 CFR 430.304 - SES performance management systems.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false SES performance management systems. 430... PERFORMANCE MANAGEMENT Managing Senior Executive Performance § 430.304 SES performance management systems. (a... or more performance management systems for its senior executives. (b) Performance management systems...

5 CFR 430.304 - SES performance management systems.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false SES performance management systems. 430... PERFORMANCE MANAGEMENT Managing Senior Executive Performance § 430.304 SES performance management systems. (a... or more performance management systems for its senior executives. (b) Performance management systems...

5 CFR 430.304 - SES performance management systems.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false SES performance management systems. 430... PERFORMANCE MANAGEMENT Managing Senior Executive Performance § 430.304 SES performance management systems. (a... or more performance management systems for its senior executives. (b) Performance management systems...

5 CFR 930.301 - Information systems security awareness training program.

Code of Federal Regulations, 2012 CFR

2012-01-01

... training in system/application life cycle management, risk management, and contingency planning. (4) Chief... security management, system/application life cycle management, risk management, and contingency planning... management; and management and implementation level training in system/application life cycle management...

United States Army Medical Materiel Development Activity: 1997 Annual Report.

DTIC Science & Technology

1997-01-01

business planning and execution information management system (Project Management Division Database ( PMDD ) and Product Management Database System (PMDS...MANAGEMENT • Project Management Division Database ( PMDD ), Product Management Database System (PMDS), and Special Users Database System:The existing...System (FMS), were investigated. New Product Managers and Project Managers were added into PMDS and PMDD . A separate division, Support, was

Development of Participative Management System in Learning Environment Management for Small Sized Primary Schools

ERIC Educational Resources Information Center

Hernthaisong, Prasertsak; Sirisuthi, Chaiyuth; Wisetrinthong, Kanjana

2017-01-01

The research aimed to: 1) study the factors of a participative management system in learning environment management, 2) study the current situation, desirable outcomes, and further needs for developing a participative management system in learning management, 3) develop a working participative management system, and 4) assess the system's…

Resource Management for Distributed Parallel Systems

NASA Technical Reports Server (NTRS)

Neuman, B. Clifford; Rao, Santosh

1993-01-01

Multiprocessor systems should exist in the the larger context of distributed systems, allowing multiprocessor resources to be shared by those that need them. Unfortunately, typical multiprocessor resource management techniques do not scale to large networks. The Prospero Resource Manager (PRM) is a scalable resource allocation system that supports the allocation of processing resources in large networks and multiprocessor systems. To manage resources in such distributed parallel systems, PRM employs three types of managers: system managers, job managers, and node managers. There exist multiple independent instances of each type of manager, reducing bottlenecks. The complexity of each manager is further reduced because each is designed to utilize information at an appropriate level of abstraction.

48 CFR 245.105 - Contractors' property management system compliance.

Code of Federal Regulations, 2011 CFR

2011-10-01

... management system compliance. 245.105 Section 245.105 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT GOVERNMENT PROPERTY General 245.105 Contractors' property management system compliance. (a) Definitions— (1) Acceptable property management system...

A system management methodology for building successful resource management systems

NASA Technical Reports Server (NTRS)

Hornstein, Rhoda Shaller; Willoughby, John K.

1989-01-01

This paper presents a system management methodology for building successful resource management systems that possess lifecycle effectiveness. This methodology is based on an analysis of the traditional practice of Systems Engineering Management as it applies to the development of resource management systems. The analysis produced fifteen significant findings presented as recommended adaptations to the traditional practice of Systems Engineering Management to accommodate system development when the requirements are incomplete, unquantifiable, ambiguous and dynamic. Ten recommended adaptations to achieve operational effectiveness when requirements are incomplete, unquantifiable or ambiguous are presented and discussed. Five recommended adaptations to achieve system extensibility when requirements are dynamic are also presented and discussed. The authors conclude that the recommended adaptations to the traditional practice of Systems Engineering Management should be implemented for future resource management systems and that the technology exists to build these systems extensibly.

41 CFR 101-39.104 - Notice of establishment of a fleet management system.

Code of Federal Regulations, 2014 CFR

2014-07-01

... management system in order to work out any problems pertaining to establishing and operating fleet management... of a fleet management system. 101-39.104 Section 101-39.104 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS AVIATION...

41 CFR 101-39.104 - Notice of establishment of a fleet management system.

Code of Federal Regulations, 2011 CFR

2011-07-01

... management system in order to work out any problems pertaining to establishing and operating fleet management... of a fleet management system. 101-39.104 Section 101-39.104 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS AVIATION...

41 CFR 101-39.104 - Notice of establishment of a fleet management system.

Code of Federal Regulations, 2013 CFR

2013-07-01

... management system in order to work out any problems pertaining to establishing and operating fleet management... of a fleet management system. 101-39.104 Section 101-39.104 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS AVIATION...

41 CFR 101-39.104 - Notice of establishment of a fleet management system.

Code of Federal Regulations, 2012 CFR

2012-07-01

... management system in order to work out any problems pertaining to establishing and operating fleet management... of a fleet management system. 101-39.104 Section 101-39.104 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS AVIATION...

5 CFR 930.301 - Information systems security awareness training program.

Code of Federal Regulations, 2011 CFR

2011-01-01

... training in system/application life cycle management, risk management, and contingency planning. (4) Chief... security management, system/application life cycle management, risk management, and contingency planning..., risk management, and contingency planning. (b) Provide the Federal information systems security...

5 CFR 930.301 - Information systems security awareness training program.

Code of Federal Regulations, 2010 CFR

2010-01-01

... training in system/application life cycle management, risk management, and contingency planning. (4) Chief... security management, system/application life cycle management, risk management, and contingency planning..., risk management, and contingency planning. (b) Provide the Federal information systems security...

14 CFR 1212.704 - System manager.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false System manager. 1212.704 Section 1212.704... Authority and Responsibilities § 1212.704 System manager. (a) Each system manager is responsible for the following with regard to the system of records over which the system manager has cognizance: (1) Overall...

77 FR 43100 - Privacy Act of 1974; Department of Homeland Security, Federal Emergency Management Agency-009...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-23

... Information System (NEMIS)--Mitigation (MT) Electronic Grants Management System of Records,'' and retitle it... Information System (NEMIS)--Mitigation (MT) Electronic Grants Management System of Records (69 FR 75079... Management Information System (NEMIS)--Mitigation (MT) Electronic Grants Management System (NEMIS--MT eGrants...

14 CFR 1212.705 - System manager.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false System manager. 1212.705 Section 1212.705... Authority and Responsibilities § 1212.705 System manager. (a) Each system manager is responsible for the following with regard to the system of records over which the system manager has cognizance: (1) Overall...

14 CFR 1212.704 - System manager.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true System manager. 1212.704 Section 1212.704... Authority and Responsibilities § 1212.704 System manager. (a) Each system manager is responsible for the following with regard to the system of records over which the system manager has cognizance: (1) Overall...

14 CFR 1212.704 - System manager.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false System manager. 1212.704 Section 1212.704... Authority and Responsibilities § 1212.704 System manager. (a) Each system manager is responsible for the following with regard to the system of records over which the system manager has cognizance: (1) Overall...

Information Security Management - Part Of The Integrated Management System

NASA Astrophysics Data System (ADS)

Manea, Constantin Adrian

2015-07-01

The international management standards allow their integrated approach, thereby combining aspects of particular importance to the activity of any organization, from the quality management systems or the environmental management of the information security systems or the business continuity management systems. Although there is no national or international regulation, nor a defined standard for the Integrated Management System, the need to implement an integrated system occurs within the organization, which feels the opportunity to integrate the management components into a cohesive system, in agreement with the purpose and mission publicly stated. The issues relating to information security in the organization, from the perspective of the management system, raise serious questions to any organization in the current context of electronic information, reason for which we consider not only appropriate but necessary to promote and implement an Integrated Management System Quality - Environment - Health and Operational Security - Information Security

41 CFR 109-1.5205 - Personal property management system changes.

Code of Federal Regulations, 2011 CFR

2011-01-01

... management system changes. 109-1.5205 Section 109-1.5205 Public Contracts and Property Management Federal Property Management Regulations System (Continued) DEPARTMENT OF ENERGY PROPERTY MANAGEMENT REGULATIONS... Personal property management system changes. Any proposed significant change to a designated contractor's...

Advanced Distribution Management Systems | Grid Modernization | NREL

Science.gov Websites

Advanced Distribution Management Systems Advanced Distribution Management Systems Electric utilities are investing in updated grid technologies such as advanced distribution management systems to management testbed for cyber security in power systems. The "advanced" elements of advanced

20 CFR 632.76 - Program management systems.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Program management systems. 632.76 Section... management systems. (a) All Native American grantees shall establish management information systems to... for the overall management of all programs including: (1) Eligibility verification systems as...

A systems engineering management approach to resource management applications

NASA Technical Reports Server (NTRS)

Hornstein, Rhoda Shaller

1989-01-01

The author presents a program management response to the following question: How can the traditional practice of systems engineering management, including requirements specification, be adapted, enhanced, or modified to build future planning and scheduling systems for effective operations? The systems engineering management process, as traditionally practiced, is examined. Extensible resource management systems are discussed. It is concluded that extensible systems are a partial solution to problems presented by requirements that are incomplete, partially immeasurable, and often dynamic. There are positive indications that resource management systems have been characterized and modeled sufficiently to allow their implementation as extensible systems.

41 CFR 101-39.104-1 - Consolidations into a fleet management system.

Code of Federal Regulations, 2011 CFR

2011-07-01

... fleet management system. 101-39.104-1 Section 101-39.104-1 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS AVIATION, TRANSPORTATION, AND MOTOR VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.1-Establishment, Modification, and...

44 CFR 13.20 - Standards for financial management systems.

Code of Federal Regulations, 2012 CFR

2012-10-01

... management systems. 13.20 Section 13.20 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT... Standards for financial management systems. (a) A State must expand and account for grant funds in... financial management systems of other grantees and subgrantees must meet the following standards: (1...

14 CFR § 1212.705 - System manager.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false System manager. § 1212.705 Section § 1212... NASA Authority and Responsibilities § 1212.705 System manager. (a) Each system manager is responsible for the following with regard to the system of records over which the system manager has cognizance...

48 CFR 2452.242-71 - Contract management system.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contract management system... 2452.242-71 Contract management system. As prescribed in 2442.1107, insert the following clause: Contract Management System (FEB 2006) (a) The contractor shall use contract management baseline planning...

Automating the Air Force Retail-Level Equipment Management Process: An Application of Microcomputer-Based Information Systems Techniques

DTIC Science & Technology

1988-09-01

could use the assistance of a microcomputer-based management information system . However, adequate system design and development requires an in-depth...understanding of the Equipment Management Section and the environment in which it functions were asked and answered. Then, a management information system was...designed, developed, and tested. The management information system is called the Equipment Management Information System (EMIS).

Warrant Officer Orientation Course (WOOC) Evaluation

DTIC Science & Technology

1981-10-01

Army Mainte- nance Management System, Security Awareness, Organizational Effectiveness, Introduction to Management , Enlisted Personnel Management...Orientation Introduction to Management Professional Ethics USA Officer Evaluation Reporting System (OES) Military Correspondence Military...Organizational Effectiveness, Introduction to Management , Enlisted Personnal Management System, and The Army Functional Files System and The Army

23 CFR 970.214 - Federal lands congestion management system (CMS).

Code of Federal Regulations, 2014 CFR

2014-04-01

... 23 Highways 1 2014-04-01 2014-04-01 false Federal lands congestion management system (CMS). 970... LANDS HIGHWAYS NATIONAL PARK SERVICE MANAGEMENT SYSTEMS National Park Service Management Systems § 970.214 Federal lands congestion management system (CMS). (a) For purposes of this section, congestion...

5 CFR 297.103 - Designations of authority by system manager.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Designations of authority by system manager. 297.103 Section 297.103 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE... system manager. The responsible Office system manager having jurisdiction over a system of records may...

25 CFR 276.7 - Standards for grantee financial management systems.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Standards for grantee financial management systems. 276.7... grantee financial management systems. (a) Grantee financial management systems for grants and subgrantee financial management systems for subgrants shall provide for: (1) Accurate, current, and complete disclosure...

41 CFR 101-39.104-1 - Consolidations into a fleet management system.

Code of Federal Regulations, 2010 CFR

2010-07-01

... fleet management system. 101-39.104-1 Section 101-39.104-1 Public Contracts and Property Management..., TRANSPORTATION, AND MOTOR VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.1-Establishment, Modification, and Discontinuance of Interagency Fleet Management Systems § 101-39.104-1 Consolidations into a fleet management...

Distribution Management System Volt/VAR Evaluation | Grid Modernization |

Science.gov Websites

NREL Distribution Management System Volt/VAR Evaluation Distribution Management System Volt/VAR Evaluation This project involves building a prototype distribution management system testbed that links a GE Grid Solutions distribution management system to power hardware-in-the-loop testing. This setup is

33 CFR 96.220 - What makes up a safety management system?

Code of Federal Regulations, 2011 CFR

2011-07-01

... SECURITY VESSEL OPERATING REGULATIONS RULES FOR THE SAFE OPERATION OF VESSELS AND SAFETY MANAGEMENT SYSTEMS Company and Vessel Safety Management Systems § 96.220 What makes up a safety management system? (a) The safety management system must document the responsible person's— (1) Safety and pollution prevention...

23 CFR 973.210 - Indian lands bridge management system (BMS).

Code of Federal Regulations, 2014 CFR

2014-04-01

... 23 Highways 1 2014-04-01 2014-04-01 false Indian lands bridge management system (BMS). 973.210... HIGHWAYS MANAGEMENT SYSTEMS PERTAINING TO THE BUREAU OF INDIAN AFFAIRS AND THE INDIAN RESERVATION ROADS PROGRAM Bureau of Indian Affairs Management Systems § 973.210 Indian lands bridge management system (BMS...

23 CFR 973.214 - Indian lands congestion management system (CMS).

Code of Federal Regulations, 2014 CFR

2014-04-01

... 23 Highways 1 2014-04-01 2014-04-01 false Indian lands congestion management system (CMS). 973.214... HIGHWAYS MANAGEMENT SYSTEMS PERTAINING TO THE BUREAU OF INDIAN AFFAIRS AND THE INDIAN RESERVATION ROADS PROGRAM Bureau of Indian Affairs Management Systems § 973.214 Indian lands congestion management system...

48 CFR 52.234-4 - Earned Value Management System.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 2 2013-10-01 2013-10-01 false Earned Value Management....234-4 Earned Value Management System. As prescribed in 34.203(c), insert the following clause: Earned Value Management System (JUL 2006) (a) The Contractor shall use an earned value management system (EVMS...

48 CFR 52.234-4 - Earned Value Management System.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 2 2012-10-01 2012-10-01 false Earned Value Management....234-4 Earned Value Management System. As prescribed in 34.203(c), insert the following clause: Earned Value Management System (JUL 2006) (a) The Contractor shall use an earned value management system (EVMS...

48 CFR 52.234-4 - Earned Value Management System.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 2 2014-10-01 2014-10-01 false Earned Value Management....234-4 Earned Value Management System. As prescribed in 34.203(c), insert the following clause: Earned Value Management System (MAY 2014) (a) The Contractor shall use an earned value management system (EVMS...

48 CFR 52.234-4 - Earned Value Management System.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 2 2011-10-01 2011-10-01 false Earned Value Management....234-4 Earned Value Management System. As prescribed in 34.203(c), insert the following clause: Earned Value Management System (JUL 2006) (a) The Contractor shall use an earned value management system (EVMS...

78 FR 37676 - Federal Acquisition Regulation; System for Award Management Name Change, Phase 1 Implementation

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-21

....204-13 System for Award Management Maintenance. * * * * * System for Award Management Maintenance (Jul...; System for Award Management Name Change, Phase 1 Implementation AGENCY: Department of Defense (DoD... System for Award Management (SAM) database. DATES: Effective Date: July 22, 2013. FOR FURTHER INFORMATION...

48 CFR 52.234-4 - Earned Value Management System.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Earned Value Management....234-4 Earned Value Management System. As prescribed in 34.203(c), insert the following clause: Earned Value Management System (JUL 2006) (a) The Contractor shall use an earned value management system (EVMS...

Information Requirements for a Procurement Management Information System.

DTIC Science & Technology

1975-08-01

Management Information System is...described and some justification for this type of procurement management information system is presented. A literature search was made to determine...information systems. If information requirements are correctly identified and satisfied by a procurement management information system , contract administration and procurement management can be

Improved Limits On The Existence Of Dark Matter. The Final Results From The PICASSO Experiment

NASA Astrophysics Data System (ADS)

Kamaha, Alvine Christelle

The final results of the PICASSO experiment, with 409 kg days of exposure collected from November 2012 to January 2014, have yielded new limits for Spin-Dependent and Spin-Independent Dark Matter interactions. The data collected and the various backgrounds were assiduously studied using Monte Carlo simulations and a new set of sophisticated analysis techniques including the wavelet analysis presented in this thesis. In general, a good suppression of most backgrounds was attained. The neutron background event rate was reduced to about a factor of 10 compared to the previous phase of the experiment. Electronic and acoustic noise events were thoroughly suppressed. A new class of "mystery events" were removed as well. All that remained was the irreducible alpha background. No signal consistent with a WIMP Dark Matter hypothesis was observed. Consequently, an exclusion curve was obtained with a minimum limit at 90% C.L. of sigmaSDchip = 0.0228 pb at a WIMP mass of 20 GeV/c2 in the Spin-Dependent sector. By combining results from 2012 and the current results, an improved constraint of sigmaSDchip (90% C.L.) = 0.0188 pb at 20 GeV/c2 was placed on the Dark Matter interaction with protons in the Fluorine nuclei used in the detectors. In addition, the new limits on WIMP-proton interactions in the Spin Independent sector exclude the DAMA/LIBRA results (at 90% C.L.) for low masses below 12 GeV/c2 and further constrain the published CRESST and CDMS Si discovery regions at low WIMP masses.

Space Situational Awareness Data Processing Scalability Utilizing Google Cloud Services

NASA Astrophysics Data System (ADS)

Greenly, D.; Duncan, M.; Wysack, J.; Flores, F.

Space Situational Awareness (SSA) is a fundamental and critical component of current space operations. The term SSA encompasses the awareness, understanding and predictability of all objects in space. As the population of orbital space objects and debris increases, the number of collision avoidance maneuvers grows and prompts the need for accurate and timely process measures. The SSA mission continually evolves to near real-time assessment and analysis demanding the need for higher processing capabilities. By conventional methods, meeting these demands requires the integration of new hardware to keep pace with the growing complexity of maneuver planning algorithms. SpaceNav has implemented a highly scalable architecture that will track satellites and debris by utilizing powerful virtual machines on the Google Cloud Platform. SpaceNav algorithms for processing CDMs outpace conventional means. A robust processing environment for tracking data, collision avoidance maneuvers and various other aspects of SSA can be created and deleted on demand. Migrating SpaceNav tools and algorithms into the Google Cloud Platform will be discussed and the trials and tribulations involved. Information will be shared on how and why certain cloud products were used as well as integration techniques that were implemented. Key items to be presented are: 1.Scientific algorithms and SpaceNav tools integrated into a scalable architecture a) Maneuver Planning b) Parallel Processing c) Monte Carlo Simulations d) Optimization Algorithms e) SW Application Development/Integration into the Google Cloud Platform 2. Compute Engine Processing a) Application Engine Automated Processing b) Performance testing and Performance Scalability c) Cloud MySQL databases and Database Scalability d) Cloud Data Storage e) Redundancy and Availability

Prognostic value of free light chains lambda and kappa in early multiple sclerosis.

PubMed

Voortman, Margarete M; Stojakovic, Tatjana; Pirpamer, Lukas; Jehna, Margit; Langkammer, Christian; Scharnagl, Hubert; Reindl, Markus; Ropele, Stefan; Seifert-Held, Thomas; Archelos, Juan-Jose; Fuchs, Siegrid; Enzinger, Christian; Fazekas, Franz; Khalil, Michael

2017-10-01

Cerebrospinal fluid (CSF) immunoglobulin free light chains (FLC) have been suggested as quantitative alternative to oligoclonal bands (OCB) in the diagnosis of multiple sclerosis (MS). However, little is known on their role in predicting clinical and paraclinical disease progression, particularly in early stages. To assess the prognostic value of FLC in OCB-positive patients with clinically isolated syndrome (CIS) suggestive of MS and early MS. We determined FLC kappa (KFLC) and lambda (LFLC) in CSF and serum by nephelometry in 61 patients (CIS ( n = 48), relapsing-remitting multiple sclerosis ( n = 13)) and 60 non-inflammatory neurological controls. Median clinical follow-up time in CIS was 4.8 years (interquartile range (IQR), 1.5-6.5 years). Patients underwent 3T magnetic resonance imaging (MRI) at baseline and follow-up (median time interval, 2.2 years; IQR, 1.0-3.7 years) to determine T2 lesion load (T2LL) and percent brain volume change (PBVC). CSF FLC were significantly increased in CIS/MS compared to controls (all p < 0.001). A lower KFLC/LFLC CSF ratio was associated with CIS-clinically definite multiple sclerosis (CDMS) conversion (hazard ratio (HR) = 2.89; 95% confidence interval (CI) = 1.17-7.14; p < 0.05). No correlations were found for FLC variables with T2LL or PBVC. Our study confirms increased intrathecal synthesis of FLC in CIS/MS which supports their diagnostic contribution. The KFLC/LFLC CSF ratio appears to have a prognostic value in CIS beyond OCB.

Low-mass dark matter search with CDMSlite

DOE PAGES

Agnese, R.; Anderson, A. J.; Aralis, T.; ...

2018-01-01

The SuperCDMS experiment is designed to directly detect WIMPs (Weakly Interacting Massive Particles) that may constitute the dark matter in our galaxy. During its operation at the Soudan Underground Laboratory, germanium detectors were run in the CDMSlite (Cryogenic Dark Matter Search low ionization threshold experiment) mode to gather data sets with sensitivity specifically for WIMPs with massesmore » $${<}10$$ GeV/$c^2$. In this mode, a large detector-bias voltage is applied to amplify the phonon signals produced by drifting charges. This paper presents studies of the experimental noise and its effect on the achievable energy threshold, which is demonstrated to be as low as 56 eV$$_{\\text{ee}}$$ (electron equivalent energy). The detector biasing configuration is described in detail, with analysis corrections for voltage variations to the level of a few percent. Detailed studies of the electric-field geometry, and the resulting successful development of a fiducial parameter, eliminate poorly measured events, yielding an energy resolution ranging from $${\\sim}$$9 eV$$_{\\text{ee}}$$ at 0 keV to 101 eV$$_{\\text{ee}}$$ at $${\\sim}$$10 keV$$_{\\text{ee}}$$. New results are derived for astrophysical uncertainties relevant to the WIMP-search limits, specifically examining how they are affected by variations in the most probable WIMP velocity and the galactic escape velocity. These variations become more important for WIMP masses below 10 GeV/$c^2$. Finally, new limits on spin-dependent low-mass WIMP-nucleon interactions are derived, with new parameter space excluded for WIMP masses $${\\lesssim}$$3 GeV/$c^2$.« less

Experience Of Implementing The Integrated Management System In Manufacturing Companies In Slovakia

NASA Astrophysics Data System (ADS)

Lestyánszka Škůrková, Katarína; Kučerová, Marta; Fidlerová, Helena

2015-06-01

In corporate practice, the term of Integrated Management System means a system the aim of which is to manage an organization regarding the quality, environment, health and safety at work. In the first phase of the VEGA project No. 1/0448/13 "Transformation of ergonomics program into the company management structure through interaction and utilization QMS, EMS, HSMS", we focused on obtaining information about the way or procedure of implementing the integrated management systems in manufacturing companies in Slovakia. The paper considers characteristics of integrated management system, specifies the possibilities for successive integration of the management systems and also describes the essential aspects of the practical implementation of integrated management systems in companies in Slovakia.

Strategic management of health care information systems: nurse managers' perceptions.

PubMed

Lammintakanen, Johanna; Kivinen, Tuula; Saranto, Kaija; Kinnunen, Juha

2009-01-01

The aim of this study is to describe nurse managers' perceptions of the strategic management of information systems in health care. Lack of strategic thinking is a typical feature in health care and this may also concern information systems. The data for this study was collected by eight focus group interviews including altogether 48 nurse managers from primary and specialised health care. Five main categories described the strategic management of information systems in health care; IT as an emphasis of strategy; lack of strategic management of information systems; the importance of management; problems in privacy protection; and costs of IT. Although IT was emphasised in the strategies of many health care organisations, a typical feature was a lack of strategic management of information systems. This was seen both as an underutilisation of IT opportunities in health care organisations and as increased workload from nurse managers' perspective. Furthermore, the nurse managers reported that implementation of IT strengthened their managerial roles but also required stronger management. In conclusion, strategic management of information systems needs to be strengthened in health care and nurse managers should be more involved in this process.

32 CFR 239.10 - Management Controls.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Systems. Headquarters, USACE has an existing information management system that manages all information related to the HAP program. (1) HAPMIS. The Homeowners Assistance Program Management Information System... to this program and the management in formation system to protect the privacy information of Expanded...

32 CFR 239.10 - Management controls.

Code of Federal Regulations, 2013 CFR

2013-07-01

... systems. Headquarters, USACE has an existing information management system that manages all information related to the HAP program. (1) HAPMIS. The Homeowners Assistance Program Management Information System... to this program and the management information system to protect the privacy of Expanded HAP...

32 CFR 239.10 - Management controls.

Code of Federal Regulations, 2012 CFR

2012-07-01

... systems. Headquarters, USACE has an existing information management system that manages all information related to the HAP program. (1) HAPMIS. The Homeowners Assistance Program Management Information System... to this program and the management information system to protect the privacy of Expanded HAP...

32 CFR 239.10 - Management controls.

Code of Federal Regulations, 2011 CFR

2011-07-01

... systems. Headquarters, USACE has an existing information management system that manages all information related to the HAP program. (1) HAPMIS. The Homeowners Assistance Program Management Information System... to this program and the management information system to protect the privacy of Expanded HAP...

23 CFR 973.208 - Indian lands pavement management system (PMS).

Code of Federal Regulations, 2013 CFR

2013-04-01

... 23 Highways 1 2013-04-01 2013-04-01 false Indian lands pavement management system (PMS). 973.208... PROGRAM Bureau of Indian Affairs Management Systems § 973.208 Indian lands pavement management system (PMS... concepts described in the AASHTO's “Pavement Management Guide.” 1 1 “Pavement Management Guide,” AASHTO...

23 CFR 973.208 - Indian lands pavement management system (PMS).

Code of Federal Regulations, 2010 CFR

2010-04-01

... 23 Highways 1 2010-04-01 2010-04-01 false Indian lands pavement management system (PMS). 973.208... PROGRAM Bureau of Indian Affairs Management Systems § 973.208 Indian lands pavement management system (PMS... concepts described in the AASHTO's “Pavement Management Guide.” 1 1 “Pavement Management Guide,” AASHTO...

23 CFR 973.208 - Indian lands pavement management system (PMS).

Code of Federal Regulations, 2012 CFR

2012-04-01

... 23 Highways 1 2012-04-01 2012-04-01 false Indian lands pavement management system (PMS). 973.208... PROGRAM Bureau of Indian Affairs Management Systems § 973.208 Indian lands pavement management system (PMS... concepts described in the AASHTO's “Pavement Management Guide.” 1 1 “Pavement Management Guide,” AASHTO...

23 CFR 973.208 - Indian lands pavement management system (PMS).

Code of Federal Regulations, 2014 CFR

2014-04-01

... 23 Highways 1 2014-04-01 2014-04-01 false Indian lands pavement management system (PMS). 973.208... PROGRAM Bureau of Indian Affairs Management Systems § 973.208 Indian lands pavement management system (PMS... concepts described in the AASHTO's “Pavement Management Guide.” 1 1 “Pavement Management Guide,” AASHTO...

23 CFR 973.208 - Indian lands pavement management system (PMS).

Code of Federal Regulations, 2011 CFR

2011-04-01

... 23 Highways 1 2011-04-01 2011-04-01 false Indian lands pavement management system (PMS). 973.208... PROGRAM Bureau of Indian Affairs Management Systems § 973.208 Indian lands pavement management system (PMS... concepts described in the AASHTO's “Pavement Management Guide.” 1 1 “Pavement Management Guide,” AASHTO...

[Relationship Between Members Satisfaction with Service Club Management Processes and Perception of Club Management System.

ERIC Educational Resources Information Center

Dawson, Frances Trigg

A study was made to determine the relationships between (1) satisfaction of members with service club management processes and member's perception of management systems, (2) perception of service club management system to selected independent variables, and (3) satisfaction to perception of service club management systems with independent…

41 CFR 302-1.100 - What is a comprehensive, automated relocation management system?

Code of Federal Regulations, 2014 CFR

2014-07-01

... system? A comprehensive, automated relocation management system is a system that integrates into a single... 41 Public Contracts and Property Management 4 2014-07-01 2014-07-01 false What is a comprehensive, automated relocation management system? 302-1.100 Section 302-1.100 Public Contracts and Property Management...

48 CFR 1052.234-72 - Core Earned Value Management System AUG 2011

Code of Federal Regulations, 2011 CFR

2011-10-01

... Management System AUG 2011 1052.234-72 Section 1052.234-72 Federal Acquisition Regulations System DEPARTMENT... and Clauses 1052.234-72 Core Earned Value Management System AUG 2011 As prescribed in DTAR 1034.203... an earned value management system (EVMS). (a) The Contractor shall use an earned value management...

41 CFR 302-1.100 - What is a comprehensive, automated relocation management system?

Code of Federal Regulations, 2013 CFR

2013-07-01

... system? A comprehensive, automated relocation management system is a system that integrates into a single... 41 Public Contracts and Property Management 4 2013-07-01 2012-07-01 true What is a comprehensive, automated relocation management system? 302-1.100 Section 302-1.100 Public Contracts and Property Management...

41 CFR 302-1.100 - What is a comprehensive, automated relocation management system?

Code of Federal Regulations, 2011 CFR

2011-07-01

... system? A comprehensive, automated relocation management system is a system that integrates into a single... 41 Public Contracts and Property Management 4 2011-07-01 2011-07-01 false What is a comprehensive, automated relocation management system? 302-1.100 Section 302-1.100 Public Contracts and Property Management...

48 CFR 1052.234-72 - Core Earned Value Management System AUG 2011

Code of Federal Regulations, 2013 CFR

2013-10-01

... Management System AUG 2011 1052.234-72 Section 1052.234-72 Federal Acquisition Regulations System DEPARTMENT... and Clauses 1052.234-72 Core Earned Value Management System AUG 2011 As prescribed in DTAR 1034.203... an earned value management system (EVMS). (a) The Contractor shall use an earned value management...

48 CFR 1052.234-72 - Core Earned Value Management System AUG 2011

Code of Federal Regulations, 2014 CFR

2014-10-01

... Management System AUG 2011 1052.234-72 Section 1052.234-72 Federal Acquisition Regulations System DEPARTMENT... and Clauses 1052.234-72 Core Earned Value Management System AUG 2011 As prescribed in DTAR 1034.203... an earned value management system (EVMS). (a) The Contractor shall use an earned value management...

41 CFR 302-1.100 - What is a comprehensive, automated relocation management system?

Code of Federal Regulations, 2012 CFR

2012-07-01

... system? A comprehensive, automated relocation management system is a system that integrates into a single... 41 Public Contracts and Property Management 4 2012-07-01 2012-07-01 false What is a comprehensive, automated relocation management system? 302-1.100 Section 302-1.100 Public Contracts and Property Management...

Environmental Files and Data Bases. Part A. Introduction and Oceanographic Management Information System.

DTIC Science & Technology

1981-09-01

Management Information System Naval Oceanography Program Naval Oceanographic Requirements Acoustic Reference Service Research Vehicle...THE OCEANOGRAPHIC MANAGEMENT INFORMATION SYSTEM . .. .... 2-1 3. ACOUSTIC DATA .. .. .... ......... ...... 3-1 4. GEOLOGICAL AND GEOPHYSICAL DATA...36 CHAPTER 2 THE OCEANOGRAPHIC MANAGEMENT INFORMATION SYSTEM 2-i CHAPTER 2 THE OCEANOGRAPHIC MANAGEMENT INFORMATION SYSTEM CONTENTS Page

76 FR 76917 - Homeless Management Information Systems Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-09

...-P-01] Homeless Management Information Systems Requirements AGENCY: Office of the Assistant Secretary... for the establishment of regulations for Homeless Management Information Systems (HMIS), which are the... community development, Homeless, Information technology system, Management system, Nonprofit organizations...

20 CFR 632.76 - Program management systems.

Code of Federal Regulations, 2010 CFR

2010-04-01

... NATIVE AMERICAN EMPLOYMENT AND TRAINING PROGRAMS Program Design and Management § 632.76 Program management systems. (a) All Native American grantees shall establish management information systems to... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Program management systems. 632.76 Section...

A Data-Based Financial Management Information System (FMIS) for Administrative Sciences Department

DTIC Science & Technology

1990-12-01

Financial Management Information System that would result in improved management of financial assets, better use of clerical skills, and more detailed...develops and implements a personal computer-based Management Information System for the Management of the many funding accounts controlled by the...different software programs, into a single all-encompassing Management Information System . The system was written using dBASE IV and is currently operational.

The influence of enterprise resource planning (ERP) systems' performance on earnings management

NASA Astrophysics Data System (ADS)

Tsai, Wen-Hsien; Lee, Kuen-Chang; Liu, Jau-Yang; Lin, Sin-Jin; Chou, Yu-Wei

2012-11-01

We analyse whether there is a linkage between performance measures of enterprise resource planning (ERP) systems and earnings management. We find that earnings management decreases with the higher performance of ERP systems. The empirical result is as expected. We further analyse how the dimension of the DeLone and McLean model of information systems success affects earnings management. We find that the relationship between the performance of ERP systems and earnings management depends on System Quality after ERP implementation. The more System Quality improves, the more earnings management is reduced.

48 CFR 245.105 - Contractor's property management system compliance.

Code of Federal Regulations, 2010 CFR

2010-10-01

... management system compliance. 245.105 Section 245.105 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT GOVERNMENT PROPERTY General 245.105 Contractor's property management system compliance. The assigned property administrator shall perform...

Integrated Computer System of Management in Logistics

NASA Astrophysics Data System (ADS)

Chwesiuk, Krzysztof

2011-06-01

This paper aims at presenting a concept of an integrated computer system of management in logistics, particularly in supply and distribution chains. Consequently, the paper includes the basic idea of the concept of computer-based management in logistics and components of the system, such as CAM and CIM systems in production processes, and management systems for storage, materials flow, and for managing transport, forwarding and logistics companies. The platform which integrates computer-aided management systems is that of electronic data interchange.

The Art World's Concept of Negative Space Applied to System Safety Management

NASA Technical Reports Server (NTRS)

Goodin, James Ronald (Ronnie)

2005-01-01

Tools from several different disciplines can improve system safety management. This paper relates the Art World with our system safety world, showing useful art schools of thought applied to system safety management, developing an art theory-system safety bridge. This bridge is then used to demonstrate relations with risk management, the legal system, personnel management and basic management (establishing priorities). One goal of this presentation/paper is simply to be a fun diversion from the many technical topics presented during the conference.

Analysis of Service Records Management Systems for Rescue and Retention of Cultural Resource Documents

DTIC Science & Technology

2009-06-01

this information was not migrated to the new data- base . The responsible offices were told to destroy the old cards, and thus, vast amounts of...then necessary to examine the online service-specific records management systems , namely Army Records Information Management System (ARIMS ), Air...Force Records Information Management System (AFRIMS), and the Navy Records Management System .3 Each system

41 CFR 102-34.340 - Do we need a fleet management information system?

Code of Federal Regulations, 2010 CFR

2010-07-01

... management information system? 102-34.340 Section 102-34.340 Public Contracts and Property Management Federal... VEHICLE MANAGEMENT Federal Fleet Report § 102-34.340 Do we need a fleet management information system? Yes, you must have a fleet management information system at the department or agency level that — (a...

41 CFR 102-34.340 - Do we need a fleet management information system?

Code of Federal Regulations, 2011 CFR

2011-01-01

... management information system? 102-34.340 Section 102-34.340 Public Contracts and Property Management Federal... VEHICLE MANAGEMENT Federal Fleet Report § 102-34.340 Do we need a fleet management information system? Yes, you must have a fleet management information system at the department or agency level that — (a...

41 CFR 102-34.340 - Do we need a fleet management information system?

Code of Federal Regulations, 2013 CFR

2013-07-01

... management information system? 102-34.340 Section 102-34.340 Public Contracts and Property Management Federal... VEHICLE MANAGEMENT Federal Fleet Report § 102-34.340 Do we need a fleet management information system? Yes, you must have a fleet management information system at the department or agency level that — (a...

41 CFR 102-34.340 - Do we need a fleet management information system?

Code of Federal Regulations, 2012 CFR

2012-01-01

... management information system? 102-34.340 Section 102-34.340 Public Contracts and Property Management Federal... VEHICLE MANAGEMENT Federal Fleet Report § 102-34.340 Do we need a fleet management information system? Yes, you must have a fleet management information system at the department or agency level that — (a...

41 CFR 102-34.340 - Do we need a fleet management information system?

Code of Federal Regulations, 2014 CFR

2014-01-01

... management information system? 102-34.340 Section 102-34.340 Public Contracts and Property Management Federal... VEHICLE MANAGEMENT Federal Fleet Report § 102-34.340 Do we need a fleet management information system? Yes, you must have a fleet management information system at the department or agency level that — (a...

48 CFR 970.5232-7 - Financial management system.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Financial management... for Management and Operating Contracts 970.5232-7 Financial management system. As prescribed in 970.3270(b)(1), insert the following clause: Financial Management System (DEC 2000) The Contractor shall...

48 CFR 970.5232-7 - Financial management system.

Code of Federal Regulations, 2010 CFR

2010-10-01

... maintain and administer a financial management system that is suitable to provide proper accounting in... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Financial management... for Management and Operating Contracts 970.5232-7 Financial management system. As prescribed in 970...

Development of the KOSMS management simulation training system and its application

NASA Astrophysics Data System (ADS)

Takatsu, Yoshiki

The use of games which simulate actual corporate management has recently become more common and is now utilized in various ways for in-house corporate training courses. KOSMS (Kobe Steel Management Simulation System), a training system designed to help improve the management skills of senior management staff, is a unique management simulation training system in which the participants, using personal computers, must make decisions concerning a variety of management activities, in simulated competition with other corporations. This report outlines the KOSMS system, and describes the basic structure and detailed contents of the management simulation models, and actual application of the KOSMS management simulation training.

Evaluation of Microcomputer-Based Operation and Maintenance Management Systems for Army Water/Wastewater Treatment Plant Operation.

DTIC Science & Technology

1986-07-01

COMPUTER-AIDED OPERATION MANAGEMENT SYSTEM ................. 29 Functions of an Off-Line Computer-Aided Operation Management System Applications of...System Comparisons 85 DISTRIBUTION 5V J. • 0. FIGURES Number Page 1 Hardware Components 21 2 Basic Functions of a Computer-Aided Operation Management System...Plant Visits 26 4 Computer-Aided Operation Management Systems Reviewed for Analysis of Basic Functions 29 5 Progress of Software System Installation and

5 CFR 9701.405 - Performance management system requirements.

Code of Federal Regulations, 2013 CFR

2013-01-01

... performance management systems for DHS employees, subject to the requirements set forth in this subpart. (b) Each DHS performance management system must— (1) Specify the employees covered by the system(s); (2... 5 Administrative Personnel 3 2013-01-01 2013-01-01 false Performance management system...

5 CFR 9701.405 - Performance management system requirements.

Code of Federal Regulations, 2011 CFR

2011-01-01

... performance management systems for DHS employees, subject to the requirements set forth in this subpart. (b) Each DHS performance management system must— (1) Specify the employees covered by the system(s); (2... 5 Administrative Personnel 3 2011-01-01 2011-01-01 false Performance management system...

5 CFR 9701.405 - Performance management system requirements.

Code of Federal Regulations, 2012 CFR

2012-01-01

... performance management systems for DHS employees, subject to the requirements set forth in this subpart. (b) Each DHS performance management system must— (1) Specify the employees covered by the system(s); (2... 5 Administrative Personnel 3 2012-01-01 2012-01-01 false Performance management system...

5 CFR 9701.405 - Performance management system requirements.

Code of Federal Regulations, 2014 CFR

2014-01-01

... performance management systems for DHS employees, subject to the requirements set forth in this subpart. (b) Each DHS performance management system must— (1) Specify the employees covered by the system(s); (2... 5 Administrative Personnel 3 2014-01-01 2014-01-01 false Performance management system...

Home and Building Energy Management Systems | Grid Modernization | NREL

Science.gov Websites

Home and Building Energy Management Systems Home and Building Energy Management Systems NREL building assets and energy management systems can provide value to the grid. Photo of a pair of NREL researchers who received a record of invention for a home energy management system in a smart home laboratory

Feasibility of Executing MIMS on Interdata 80.

DTIC Science & Technology

CDC 6500 computers, CDC 6600 computers, MIMS(Medical Information Management System ), Medical information management system , File structures, Computer...storage managementThe report examines the feasibility of implementing large information management system on mini-computers. The Medical Information ... Management System and the Interdata 80 mini-computer were selected as being representative systems. The FORTRAN programs currently being used in MIMS

Design distributed simulation platform for vehicle management system

NASA Astrophysics Data System (ADS)

Wen, Zhaodong; Wang, Zhanlin; Qiu, Lihua

2006-11-01

Next generation military aircraft requires the airborne management system high performance. General modules, data integration, high speed data bus and so on are needed to share and manage information of the subsystems efficiently. The subsystems include flight control system, propulsion system, hydraulic power system, environmental control system, fuel management system, electrical power system and so on. The unattached or mixed architecture is changed to integrated architecture. That means the whole airborne system is regarded into one system to manage. So the physical devices are distributed but the system information is integrated and shared. The process function of each subsystem are integrated (including general process modules, dynamic reconfiguration), furthermore, the sensors and the signal processing functions are shared. On the other hand, it is a foundation for power shared. Establish a distributed vehicle management system using 1553B bus and distributed processors which can provide a validation platform for the research of airborne system integrated management. This paper establishes the Vehicle Management System (VMS) simulation platform. Discuss the software and hardware configuration and analyze the communication and fault-tolerant method.

48 CFR 1034.201 - Policy.

Code of Federal Regulations, 2014 CFR

2014-10-01

... CONTRACTING MAJOR SYSTEM ACQUISITION Earned Value Management System 1034.201 Policy. (a) (1) An Earned Value Management System (EVMS) is required for major acquisitions for development/modernization/enhancement (DME..., Earned Value Management System; and, as appropriate, 1052.234-4, Earned Value Management System Alternate...

48 CFR 1034.201 - Policy.

Code of Federal Regulations, 2013 CFR

2013-10-01

... CONTRACTING MAJOR SYSTEM ACQUISITION Earned Value Management System 1034.201 Policy. (a) (1) An Earned Value Management System (EVMS) is required for major acquisitions for development/modernization/enhancement (DME..., Earned Value Management System; and, as appropriate, 1052.234-4, Earned Value Management System Alternate...

48 CFR 1034.201 - Policy.

Code of Federal Regulations, 2012 CFR

2012-10-01

... CONTRACTING MAJOR SYSTEM ACQUISITION Earned Value Management System 1034.201 Policy. (a) (1) An Earned Value Management System (EVMS) is required for major acquisitions for development/modernization/enhancement (DME..., Earned Value Management System; and, as appropriate, 1052.234-4, Earned Value Management System Alternate...

Design of investment management optimization system for power grid companies under new electricity reform

NASA Astrophysics Data System (ADS)

Yang, Chunhui; Su, Zhixiong; Wang, Xin; Liu, Yang; Qi, Yongwei

2017-03-01

The new normalization of the economic situation and the implementation of a new round of electric power system reform put forward higher requirements to the daily operation of power grid companies. As an important day-to-day operation of power grid companies, investment management is directly related to the promotion of the company's operating efficiency and management level. In this context, the establishment of power grid company investment management optimization system will help to improve the level of investment management and control the company, which is of great significance for power gird companies to adapt to market environment changing as soon as possible and meet the policy environment requirements. Therefore, the purpose of this paper is to construct the investment management optimization system of power grid companies, which includes investment management system, investment process control system, investment structure optimization system, and investment project evaluation system and investment management information platform support system.

75 FR 41798 - Solicitation of Letters of Interest to Participate in Biotechnology Quality Management System...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-19

...] Solicitation of Letters of Interest to Participate in Biotechnology Quality Management System Program AGENCY... participate in the APHIS Biotechnology Quality Management System Program. The Biotechnology Quality Management..., audit-based compliance assistance program known as the Biotechnology Quality Management System Program...

75 FR 61413 - Notice of Availability of Biotechnology Quality Management System Audit Standard and Evaluation...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-05

...] Notice of Availability of Biotechnology Quality Management System Audit Standard and Evaluation of... Biotechnology Quality Management System Program (BQMS Program) to assist regulated entities in achieving and... customized biotechnology quality management system (BQMS) to improve their management of domestic research...

25 CFR 900.54 - Should the property management system prescribe internal controls?

Code of Federal Regulations, 2010 CFR

2010-04-01

... EDUCATION ASSISTANCE ACT Standards for Tribal or Tribal Organization Management Systems Property Management... contract consistent with the Indian tribe or tribal organization's property management system. ... 25 Indians 2 2010-04-01 2010-04-01 false Should the property management system prescribe internal...

25 CFR 900.54 - Should the property management system prescribe internal controls?

Code of Federal Regulations, 2011 CFR

2011-04-01

... EDUCATION ASSISTANCE ACT Standards for Tribal or Tribal Organization Management Systems Property Management... contract consistent with the Indian tribe or tribal organization's property management system. ... 25 Indians 2 2011-04-01 2011-04-01 false Should the property management system prescribe internal...

41 CFR 105-71.120 - Standards for financial management systems.

Code of Federal Regulations, 2011 CFR

2011-01-01

... management systems. 105-71.120 Section 105-71.120 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION Regional Offices-General Services... management systems. (a) A State must expand and account for grant funds in accordance with State laws and...

41 CFR 105-71.120 - Standards for financial management systems.

Code of Federal Regulations, 2014 CFR

2014-01-01

... management systems. 105-71.120 Section 105-71.120 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION Regional Offices-General Services... management systems. (a) A State must expand and account for grant funds in accordance with State laws and...

22 CFR 145.21 - Standards for financial management systems.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Standards for financial management systems. 145... Financial and Program Management § 145.21 Standards for financial management systems. (a) The Department... whenever practical. (b) Recipients' financial management systems shall provide for the following. (1...

29 CFR 95.21 - Standards for financial management systems.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 1 2010-07-01 2010-07-01 true Standards for financial management systems. 95.21 Section 95... Requirements Financial and Program Management § 95.21 Standards for financial management systems. (a... practical. (b) Recipients' financial management systems shall provide for the following: (1) Accurate...

7 CFR 3019.21 - Standards for financial management systems.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Standards for financial management systems. 3019.21... Requirements Financial and Program Management § 3019.21 Standards for financial management systems. (a) Federal... cost information whenever practical. (b) Recipients' financial management systems shall provide for the...

75 FR 21264 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-23

... Defense. A0030-22 AMC System name: Army Food Management Information System Records System location.... 9397, as amended. Purpose(s): The Army Food Management Information System will be used to automate the...: Supervisor, Army Food Management Information System, Program Manager, 401 First Street, Suite 157, Fort Lee...

Transportation infrastructure : states' implementation of transportation management systems

DOT National Transportation Integrated Search

1997-01-13

This report focuses on the U.S. General Accounting Office's ISTEA update of the states' implementation of pavement management systems, bridges, highway safety, congestion management systems, public transportation, and intermodal management systems. A...

Intelligent community management system based on the devicenet fieldbus

NASA Astrophysics Data System (ADS)

Wang, Yulan; Wang, Jianxiong; Liu, Jiwen

2013-03-01

With the rapid development of the national economy and the improvement of people's living standards, people are making higher demands on the living environment. And the estate management content, management efficiency and service quality have been higher required. This paper in-depth analyzes about the intelligent community of the structure and composition. According to the users' requirements and related specifications, it achieves the district management systems, which includes Basic Information Management: the management level of housing, household information management, administrator-level management, password management, etc. Service Management: standard property costs, property charges collecting, the history of arrears and other property expenses. Security Management: household gas, water, electricity and security and other security management, security management district and other public places. Systems Management: backup database, restore database, log management. This article also carries out on the Intelligent Community System analysis, proposes an architecture which is based on B / S technology system. And it has achieved a global network device management with friendly, easy to use, unified human - machine interface.

An Approach for Implementation of Project Management Information Systems

NASA Astrophysics Data System (ADS)

Běrziša, Solvita; Grabis, Jānis

Project management is governed by project management methodologies, standards, and other regulatory requirements. This chapter proposes an approach for implementing and configuring project management information systems according to requirements defined by these methodologies. The approach uses a project management specification framework to describe project management methodologies in a standardized manner. This specification is used to automatically configure the project management information system by applying appropriate transformation mechanisms. Development of the standardized framework is based on analysis of typical project management concepts and process and existing XML-based representations of project management. A demonstration example of project management information system's configuration is provided.

5 CFR 430.304 - SES performance management systems.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false SES performance management systems. 430.304 Section 430.304 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PERFORMANCE MANAGEMENT Managing Senior Executive Performance § 430.304 SES performance management systems. (a...

23 CFR 970.204 - Management systems requirements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... the management systems and their associated databases; and (5) A process for data collection, processing, analysis and updating for each management system. (d) All management systems will use databases with a geographical reference system that can be used to geolocate all database information. (e...

23 CFR 970.204 - Management systems requirements.

Code of Federal Regulations, 2012 CFR

2012-04-01

... the management systems and their associated databases; and (5) A process for data collection, processing, analysis and updating for each management system. (d) All management systems will use databases with a geographical reference system that can be used to geolocate all database information. (e...

23 CFR 970.204 - Management systems requirements.

Code of Federal Regulations, 2011 CFR

2011-04-01

... the management systems and their associated databases; and (5) A process for data collection, processing, analysis and updating for each management system. (d) All management systems will use databases with a geographical reference system that can be used to geolocate all database information. (e...

23 CFR 970.204 - Management systems requirements.

Code of Federal Regulations, 2013 CFR

2013-04-01

... the management systems and their associated databases; and (5) A process for data collection, processing, analysis and updating for each management system. (d) All management systems will use databases with a geographical reference system that can be used to geolocate all database information. (e...

The Management and Demonstration System at Murray State University.

ERIC Educational Resources Information Center

Schroeder, Gary G.

The management system in use at the Murray State University Teacher Corps Project is described. The system uses management by objectives and the demonstration approach, and encourages managers to focus on the development and demonstration of ideas, processes, and structures. The system's operating concepts of time management and human resources…

5 CFR 297.103 - Designations of authority by system manager.

Code of Federal Regulations, 2012 CFR

2012-01-01

... manager. 297.103 Section 297.103 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE... system manager. The responsible Office system manager having jurisdiction over a system of records may designate in writing an Office employee to evaluate and issue the Office's decision on Privacy Act matters...

5 CFR 297.103 - Designations of authority by system manager.

Code of Federal Regulations, 2014 CFR

2014-01-01

... manager. 297.103 Section 297.103 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE... system manager. The responsible Office system manager having jurisdiction over a system of records may designate in writing an Office employee to evaluate and issue the Office's decision on Privacy Act matters...

5 CFR 297.103 - Designations of authority by system manager.

Code of Federal Regulations, 2011 CFR

2011-01-01

... manager. 297.103 Section 297.103 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE... system manager. The responsible Office system manager having jurisdiction over a system of records may designate in writing an Office employee to evaluate and issue the Office's decision on Privacy Act matters...

5 CFR 297.103 - Designations of authority by system manager.

Code of Federal Regulations, 2013 CFR

2013-01-01

... manager. 297.103 Section 297.103 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE... system manager. The responsible Office system manager having jurisdiction over a system of records may designate in writing an Office employee to evaluate and issue the Office's decision on Privacy Act matters...

Correlation Research of Medical Security Management System Network Platform in Medical Practice

NASA Astrophysics Data System (ADS)

Jie, Wang; Fan, Zhang; Jian, Hao; Li-nong, Yu; Jun, Fei; Ping, Hao; Ya-wei, Shen; Yue-jin, Chang

Objective-The related research of medical security management system network in medical practice. Methods-Establishing network platform of medical safety management system, medical security network host station, medical security management system(C/S), medical security management system of departments and sections, comprehensive query, medical security disposal and examination system. Results-In medical safety management, medical security management system can reflect the hospital medical security problem, and can achieve real-time detection and improve the medical security incident detection rate. Conclusion-The application of the research in the hospital management implementation, can find hospital medical security hidden danger and the problems of medical disputes, and can help in resolving medical disputes in time and achieve good work efficiency, which is worth applying in the hospital practice.

77 FR 49011 - Privacy Act of 1974; New System of Records, Office of General Counsel E-Discovery Management...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-15

... System of Records, Office of General Counsel E-Discovery Management System--Change in Final Effective... the OGC E-Discovery Management System until after the opportunity for further comment is provided to... intent to establish a new system of records for OGC's E-Discovery Management System (EDMS), a system...

77 FR 68140 - Privacy Act of 1974; New System of Records, Office of General Counsel E-Discovery Management...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-15

... System of Records, Office of General Counsel E-Discovery Management System: Republication of System... Counsel (OGC) E- Discovery Management System (EDMS). EDMS was first announced and described in a July 17... for OGC's E-Discovery Management System (OGC-EDMS), a system expected to significantly improve the...

Information management

NASA Technical Reports Server (NTRS)

Ricks, Wendell; Corker, Kevin

1990-01-01

Primary Flight Display (PFD) information management and cockpit display of information management research is presented in viewgraph form. The information management problem in the cockpit, information management burdens, the key characteristics of an information manager, the interface management system handling the flow of information and the dialogs between the system and the pilot, and overall system architecture are covered.

[The future of clinical laboratory database management system].

PubMed

Kambe, M; Imidy, D; Matsubara, A; Sugimoto, Y

1999-09-01

To assess the present status of the clinical laboratory database management system, the difference between the Clinical Laboratory Information System and Clinical Laboratory System was explained in this study. Although three kinds of database management systems (DBMS) were shown including the relational model, tree model and network model, the relational model was found to be the best DBMS for the clinical laboratory database based on our experience and developments of some clinical laboratory expert systems. As a future clinical laboratory database management system, the IC card system connected to an automatic chemical analyzer was proposed for personal health data management and a microscope/video system was proposed for dynamic data management of leukocytes or bacteria.

41 CFR 109-1.5205 - Personal property management system changes.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Personal property management system changes. 109-1.5205 Section 109-1.5205 Public Contracts and Property Management Federal Property Management Regulations System (Continued) DEPARTMENT OF ENERGY PROPERTY MANAGEMENT REGULATIONS...

48 CFR 252.245-7003 - Contractor Property Management System Administration.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Management System Administration. 252.245-7003 Section 252.245-7003 Federal Acquisition Regulations System... AND CONTRACT CLAUSES Text of Provisions And Clauses 252.245-7003 Contractor Property Management System Administration. As prescribed in 245.107, insert the following clause: CONTRACTOR PROPERTY MANAGEMENT SYSTEM...

23 CFR 971.204 - Management systems requirements.

Code of Federal Regulations, 2011 CFR

2011-04-01

... maintain the management systems and their associated databases; and (5) A process for data collection, processing, analysis, and updating for each management system. (c) All management systems will use databases with a common or coordinated reference system, that can be used to geolocate all database information...

23 CFR 971.204 - Management systems requirements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... maintain the management systems and their associated databases; and (5) A process for data collection, processing, analysis, and updating for each management system. (c) All management systems will use databases with a common or coordinated reference system, that can be used to geolocate all database information...

23 CFR 971.204 - Management systems requirements.

Code of Federal Regulations, 2012 CFR

2012-04-01

... maintain the management systems and their associated databases; and (5) A process for data collection, processing, analysis, and updating for each management system. (c) All management systems will use databases with a common or coordinated reference system, that can be used to geolocate all database information...

23 CFR 971.204 - Management systems requirements.

Code of Federal Regulations, 2013 CFR

2013-04-01

... maintain the management systems and their associated databases; and (5) A process for data collection, processing, analysis, and updating for each management system. (c) All management systems will use databases with a common or coordinated reference system, that can be used to geolocate all database information...

Design and implement of mobile equipment management system based on QRcode

NASA Astrophysics Data System (ADS)

Yu, Runze; Duan, Xiaohui; Jiao, Bingli

2017-08-01

A mobile equipment management system based on QRcode is proposed for remote and convenient device management. Unlike conventional systems, the system here makes managers accessible to real-time information with smart phones. Compared with the conventional method, which can only be operated with specific devices, this lightweight and efficient tele management mode is conducive to the asset management in multiple scenarios.

41 CFR 101-1.101 - Federal Property Management Regulations System.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Federal Property Management Regulations System. 101-1.101 Section 101-1.101 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS GENERAL 1-INTRODUCTION 1.1...

20 CFR 637.300 - Management systems, reporting and recordkeeping.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Management systems, reporting and... Standards and Procedures § 637.300 Management systems, reporting and recordkeeping. (a) The Governor shall ensure that the State's financial management system and recordkeeping system comply with subpart D of...

48 CFR 52.223-19 - Compliance with Environmental Management Systems.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Environmental Management Systems. 52.223-19 Section 52.223-19 Federal Acquisition Regulations System FEDERAL... Provisions and Clauses 52.223-19 Compliance with Environmental Management Systems. As prescribed in 23.903, insert the following clause: Compliance With Environmental Management Systems (May 2011) The Contractor's...

10 CFR 600.311 - Standards for financial management systems.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Standards for financial management systems. 600.311... Requirements § 600.311 Standards for financial management systems. (a) Recipients are encouraged to use existing financial management systems to the extent that the systems comply with Generally Accepted...

10 CFR 600.311 - Standards for financial management systems.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Standards for financial management systems. 600.311... Requirements § 600.311 Standards for financial management systems. (a) Recipients are encouraged to use existing financial management systems to the extent that the systems comply with Generally Accepted...

Master's Degree in Management Information Systems with a Supply Chain Management Focus

ERIC Educational Resources Information Center

Ramaswamy, Kizhanatham V.; Boyd, Joseph L.; Desai, Mayur

2007-01-01

A graduate curriculum in Management Information Systems with a Supply Chain Management focus is presented. The motivation for this endeavor stems from the fact that the global scope of modern business organizations and the competitive environment in which they operate, requires an information system leveraged supply chain management system (SCM)…

33 CFR 96.220 - What makes up a safety management system?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false What makes up a safety management... SECURITY VESSEL OPERATING REGULATIONS RULES FOR THE SAFE OPERATION OF VESSELS AND SAFETY MANAGEMENT SYSTEMS Company and Vessel Safety Management Systems § 96.220 What makes up a safety management system? (a) The...

Planning and Resource Management in an Intelligent Automated Power Management System

NASA Technical Reports Server (NTRS)

Morris, Robert A.

1991-01-01

Power system management is a process of guiding a power system towards the objective of continuous supply of electrical power to a set of loads. Spacecraft power system management requires planning and scheduling, since electrical power is a scarce resource in space. The automation of power system management for future spacecraft has been recognized as an important R&D goal. Several automation technologies have emerged including the use of expert systems for automating human problem solving capabilities such as rule based expert system for fault diagnosis and load scheduling. It is questionable whether current generation expert system technology is applicable for power system management in space. The objective of the ADEPTS (ADvanced Electrical Power management Techniques for Space systems) is to study new techniques for power management automation. These techniques involve integrating current expert system technology with that of parallel and distributed computing, as well as a distributed, object-oriented approach to software design. The focus of the current study is the integration of new procedures for automatically planning and scheduling loads with procedures for performing fault diagnosis and control. The objective is the concurrent execution of both sets of tasks on separate transputer processors, thus adding parallelism to the overall management process.

SSCR Automated Manager (SAM) release 1. 1 reference manual

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1988-10-01

This manual provides instructions for using the SSCR Automated Manager (SAM) to manage System Software Change Records (SSCRs) online. SSCRs are forms required to document all system software changes for the Martin Marietta Energy Systems, Inc., Central computer systems. SAM, a program developed at Energy Systems, is accessed through IDMS/R (Integrated Database Management System) on an IBM system.

Applying management information systems to staffing.

PubMed

Hanson, R L

1982-10-01

A management information system (MIS) is a tool for managing resources effectively. After reviewing some concepts and principles for effective data management, Hanson clearly applies the concepts to nurse staffing systems, which manage human resources. He defines a seven-step process for establishing an MIS, from defining the management objective to implementing the system. Pointing out that an MIS need not be computerized to be effective, Hanson presents a positive perspective and clarifies some often-misconceived notions about management information systems and the paper printouts they generate. In the next issue of JONA, a second article by Hanson will take a more detailed look at the variety, use, and usefulness of staffing statistics available from an MIS for staffing. These articles are based on material in a forthcoming book, Management Systems for Nursing Service Staffing, to be published by Aspen Systems Corporation, Rockville, Maryland.

Case management information systems: how to put the pieces together now and beyond year 2000.

PubMed

Matthews, Pamela

2002-01-01

The case management process is a critical management and operational component in the delivery of customer services across the patient care continuum. Case management has transcended time and will continue to be a viable infrastructure process for successful organizations in the future. A key component of the case management infrastructure is information systems and technology support. Case management challenges include effective deployment and use of systems and technology. As more sophisticated, integrated systems are made available, case managers can use these tools to continue to expand effectively beyond the patient's episodic event to provide greater levels of cradle-to-grave management of healthcare. This article explores methods for defining case management system needs and identifying automation options available to the case manager.

5 CFR 9701.410 - DHS responsibilities.

Code of Federal Regulations, 2012 CFR

2012-01-01

... RESOURCES MANAGEMENT SYSTEM Performance Management § 9701.410 DHS responsibilities. In carrying out its performance management system(s), DHS must— (a) Transfer ratings between subordinate organizations and to... 9701.410 Administrative Personnel DEPARTMENT OF HOMELAND SECURITY HUMAN RESOURCES MANAGEMENT SYSTEM...

5 CFR 9701.410 - DHS responsibilities.

Code of Federal Regulations, 2014 CFR

2014-01-01

... RESOURCES MANAGEMENT SYSTEM Performance Management § 9701.410 DHS responsibilities. In carrying out its performance management system(s), DHS must— (a) Transfer ratings between subordinate organizations and to... 9701.410 Administrative Personnel DEPARTMENT OF HOMELAND SECURITY HUMAN RESOURCES MANAGEMENT SYSTEM...

5 CFR 9701.410 - DHS responsibilities.

Code of Federal Regulations, 2011 CFR

2011-01-01

... RESOURCES MANAGEMENT SYSTEM Performance Management § 9701.410 DHS responsibilities. In carrying out its performance management system(s), DHS must— (a) Transfer ratings between subordinate organizations and to... 9701.410 Administrative Personnel DEPARTMENT OF HOMELAND SECURITY HUMAN RESOURCES MANAGEMENT SYSTEM...

Microcomputer Database Management Systems for Bibliographic Data.

ERIC Educational Resources Information Center

Pollard, Richard

1986-01-01

Discusses criteria for evaluating microcomputer database management systems (DBMS) used for storage and retrieval of bibliographic data. Two popular types of microcomputer DBMS--file management systems and relational database management systems--are evaluated with respect to these criteria. (Author/MBR)

5 CFR 9701.405 - Performance management system requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... requirements. 9701.405 Section 9701.405 Administrative Personnel DEPARTMENT OF HOMELAND SECURITY HUMAN RESOURCES MANAGEMENT SYSTEM (DEPARTMENT OF HOMELAND SECURITY-OFFICE OF PERSONNEL MANAGEMENT) DEPARTMENT OF HOMELAND SECURITY HUMAN RESOURCES MANAGEMENT SYSTEM Performance Management § 9701.405 Performance...

32 CFR 34.23 - Property management system.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 1 2010-07-01 2010-07-01 false Property management system. 34.23 Section 34.23... Requirements Property Standards § 34.23 Property management system. The recipient's property management system... control system shall be in effect to insure adequate safeguards to prevent loss, damage, or theft of the...

10 CFR 600.323 - Property management system.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Property management system. 600.323 Section 600.323 Energy....323 Property management system. The recipient's property management system must include the following... existence, current utilization, and continued need for the property. (d) A control system must be in effect...

The Implementation of an Office Systems Management Curriculum for the 1980s.

ERIC Educational Resources Information Center

Stallard, John J.

1982-01-01

Describes the implementation of an office systems management curriculum (at the University of Tennessee, Knoxville) that trains students to develop their conceptual skills and to train for management-level positions. Courses involve the automated office, records systems, office systems analysis, case studies, and management information systems.…

32 CFR 34.23 - Property management system.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 1 2011-07-01 2011-07-01 false Property management system. 34.23 Section 34.23... Requirements Property Standards § 34.23 Property management system. The recipient's property management system... control system shall be in effect to insure adequate safeguards to prevent loss, damage, or theft of the...

10 CFR 600.323 - Property management system.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Property management system. 600.323 Section 600.323 Energy....323 Property management system. The recipient's property management system must include the following... existence, current utilization, and continued need for the property. (d) A control system must be in effect...

Systems Management of Air Force Standard Communications-Computer systems: There is a Better Way

DTIC Science & Technology

1988-04-01

upgrade or replacement of systems. AFR 700-6, Information Systems Operation Management , AFR 700-7, Information Processing Center Opera- tions Management...and AFR 700-8, Telephone Systems Operation Management provide USAF guidance, policy and procedures governing this phase. 4 2. 800-Series Regulations

48 CFR 352.234-4 - Partial earned value management system.

Code of Federal Regulations, 2013 CFR

2013-10-01

... management system. 352.234-4 Section 352.234-4 Federal Acquisition Regulations System HEALTH AND HUMAN....234-4 Partial earned value management system. As prescribed in 334.203-70(d), the Contracting Officer shall insert the following clause: Partial Earned Value Management System (October 2008) (a) The...

48 CFR 352.234-4 - Partial earned value management system.

Code of Federal Regulations, 2012 CFR

2012-10-01

... management system. 352.234-4 Section 352.234-4 Federal Acquisition Regulations System HEALTH AND HUMAN....234-4 Partial earned value management system. As prescribed in 334.203-70(d), the Contracting Officer shall insert the following clause: Partial Earned Value Management System (October 2008) (a) The...

48 CFR 352.234-3 - Full earned value management system.

Code of Federal Regulations, 2014 CFR

2014-10-01

... management system. 352.234-3 Section 352.234-3 Federal Acquisition Regulations System HEALTH AND HUMAN....234-3 Full earned value management system. As prescribed in 334.203-70(c), the Contracting Officer shall insert the following clause: Full Earned Value Management System (October 2008) (a) The Contractor...

48 CFR 352.234-4 - Partial earned value management system.

Code of Federal Regulations, 2014 CFR

2014-10-01

... management system. 352.234-4 Section 352.234-4 Federal Acquisition Regulations System HEALTH AND HUMAN....234-4 Partial earned value management system. As prescribed in 334.203-70(d), the Contracting Officer shall insert the following clause: Partial Earned Value Management System (October 2008) (a) The...

48 CFR 352.234-3 - Full earned value management system.

Code of Federal Regulations, 2013 CFR

2013-10-01

... management system. 352.234-3 Section 352.234-3 Federal Acquisition Regulations System HEALTH AND HUMAN....234-3 Full earned value management system. As prescribed in 334.203-70(c), the Contracting Officer shall insert the following clause: Full Earned Value Management System (October 2008) (a) The Contractor...

48 CFR 352.234-3 - Full earned value management system.

Code of Federal Regulations, 2012 CFR

2012-10-01

... management system. 352.234-3 Section 352.234-3 Federal Acquisition Regulations System HEALTH AND HUMAN....234-3 Full earned value management system. As prescribed in 334.203-70(c), the Contracting Officer shall insert the following clause: Full Earned Value Management System (October 2008) (a) The Contractor...

48 CFR 352.234-4 - Partial earned value management system.

Code of Federal Regulations, 2011 CFR

2011-10-01

... management system. 352.234-4 Section 352.234-4 Federal Acquisition Regulations System HEALTH AND HUMAN....234-4 Partial earned value management system. As prescribed in 334.203-70(d), the Contracting Officer shall insert the following clause: Partial Earned Value Management System (October 2008) (a) The...

48 CFR 352.234-3 - Full earned value management system.

Code of Federal Regulations, 2011 CFR

2011-10-01

... management system. 352.234-3 Section 352.234-3 Federal Acquisition Regulations System HEALTH AND HUMAN....234-3 Full earned value management system. As prescribed in 334.203-70(c), the Contracting Officer shall insert the following clause: Full Earned Value Management System (October 2008) (a) The Contractor...

48 CFR 252.234-7001 - Notice of Earned Value Management System.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Industries Alliance Standard 748, Earned Value Management Systems (ANSI/EIA-748) (current version at time of... Management System. 252.234-7001 Section 252.234-7001 Federal Acquisition Regulations System DEFENSE... CLAUSES Text of Provisions And Clauses 252.234-7001 Notice of Earned Value Management System. As...

36 CFR 212.5 - Road system management.

Code of Federal Regulations, 2011 CFR

2011-07-01

... safety or to environmental degradation. (c) Cost recovery on National Forest System roads. The Chief may... 36 Parks, Forests, and Public Property 2 2011-07-01 2011-07-01 false Road system management. 212.5... MANAGEMENT Administration of the Forest Transportation System § 212.5 Road system management. (a) Traffic...

Current Standardization and Cooperative Efforts Related to Industrial Information Infrastructures.

DTIC Science & Technology

1993-05-01

Data Management Systems: Components used to store, manage, and retrieve data. Data management includes knowledge bases, database management...Application Development Tools and Methods X/Open and POSIX APIs Integrated Design Support System (IDS) Knowledge -Based Systems (KBS) Application...IDEFlx) Yourdon Jackson System Design (JSD) Knowledge -Based Systems (KBSs) Structured Systems Development (SSD) Semantic Unification Meta-Model

Integrated management system: The integration of ISO 9001, ISO 14001, OHSAS 18001 and ISO 31000

NASA Astrophysics Data System (ADS)

Muzaimi, Hafizzudin; Chew, Boon Cheong; Hamid, Syaiful Rizal

2017-03-01

The implementation of integrated management system (IMS) for better quality management has become a preference for many organizations. This can be seen as many organizations used the combination of quality ISO 9001, an environment ISO 14001 and occupational health and safety management system OHSAS 18001 as a core for the IMS that largely implemented. Besides, the linked between quality management with risk management system need to be identified as the management system that enhance the effectiveness of IMS. Therefore, the risk management system ISO 31000 also presented as a part of integration. In nowadays competitive environment, the increasing pressure and needs from customer or stakeholders make it compulsory for the organization to propose the new system and standards. This paper presents and discusses about the benefit of integration, the management system components that can be converged and the implementation approach. A series of interview was conducted through in-depth interviews with 8 experts in this field, while data collected were analyzed qualitatively. The results consist of 16 factors of IMS implementation that have been identified and the use of PDCA approach for an effective implementation of IMS. As a conclusion, the paper proposes the integration of four management systems (ISO 9001, ISO 14001, OHSAS 18001 and ISO 31000) and on how the IMS can be used to structure the process of management for quality management towards sustainability practices in the organization.

Fit for purpose quality management system for military forensic exploitation.

PubMed

Wilson, Lauren Elizabeth; Gahan, Michelle Elizabeth; Robertson, James; Lennard, Chris

2018-03-01

In a previous publication we described a systems approach to forensic science applied in the military domain. The forensic science 'system of systems' describes forensic science as a sub-system in the larger criminal justice, law enforcement, intelligence, and military systems, with quality management being an important supporting system. Quality management systems help to ensure that organisations achieve their objective and continually improve their capability. Components of forensic science quality management systems can include standardisation of processes, accreditation of facilities to national/international standards, and certification of personnel. A fit for purpose quality management system should be balanced to allow organisations to meet objectives, provide continuous improvement; mitigate risk; and impart a positive quality culture. Considerable attention over the last decades has been given to the need for forensic science quality management systems to meet criminal justice and law enforcement objectives. More recently, the need for the forensic quality management systems to meet forensic intelligence objectives has been considered. This paper, for the first time, discusses the need for a fit for purpose quality management system for military forensic exploitation. Crown Copyright © 2018. Published by Elsevier B.V. All rights reserved.

Analysis of the Apollo spacecraft operational data management system. Executive summary

NASA Technical Reports Server (NTRS)

1971-01-01

A study was made of Apollo, Skylab, and several other data management systems to determine those techniques which could be applied to the management of operational data for future manned spacecraft programs. The results of the study are presented and include: (1) an analysis of present data management systems, (2) a list of requirements for future operational data management systems, (3) an evaluation of automated data management techniques, and (4) a plan for data management applicable to future space programs.

30 CFR 585.810 - What must I include in my Safety Management System?

Code of Federal Regulations, 2013 CFR

2013-07-01

..., COPs and GAPs Safety Management Systems § 585.810 What must I include in my Safety Management System? You must submit a description of the Safety Management System you will use with your COP (provided...

30 CFR 585.810 - What must I include in my Safety Management System?

Code of Federal Regulations, 2014 CFR

2014-07-01

..., COPs and GAPs Safety Management Systems § 585.810 What must I include in my Safety Management System? You must submit a description of the Safety Management System you will use with your COP (provided...

30 CFR 585.810 - What must I include in my Safety Management System?

Code of Federal Regulations, 2012 CFR

2012-07-01

..., COPs and GAPs Safety Management Systems § 585.810 What must I include in my Safety Management System? You must submit a description of the Safety Management System you will use with your COP (provided...

Management advisory memorandum on National Airspace System infrastructure management system prototype, Federal Aviation Administration

DOT National Transportation Integrated Search

1997-03-01

This is our Management Advisory Memorandum on the National Airspace : System (NAS) Infrastructure Management System (NIMS) prototype : project in the Federal Aviation Administration (FAA). Our review was : initiated in response to a hotline complaint...

23 CFR 971.204 - Management systems requirements.

Code of Federal Regulations, 2014 CFR

2014-04-01

... Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL LANDS HIGHWAYS FOREST SERVICE... maintain the management systems and their associated databases; and (5) A process for data collection, processing, analysis, and updating for each management system. (c) All management systems will use databases...

23 CFR 970.204 - Management systems requirements.

Code of Federal Regulations, 2014 CFR

2014-04-01

... Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL LANDS HIGHWAYS NATIONAL PARK... the management systems and their associated databases; and (5) A process for data collection, processing, analysis and updating for each management system. (d) All management systems will use databases...

A Study of MX Environmental Management Information System (MXEMIS) Needs.

DTIC Science & Technology

1983-12-01

ENVIRONMENTAL MANAGEMENT INFORMATION SYSTEM (MXEMIS) NEEDS by Ronald Webster Ralph Mitchell Valorie Young -J : 2 34 LA--. Approved for public release...System (SAIFS) The MX Management Information System (MX MIS) The Mobilization Early Warning System (MEWS) The Computer-Aided Environmental Baseline...26 REFERENCES DISTRIBUTION I5 S’ t A STUDY OF MX ENVIRONMENTAL 2 EXISTING SYSTEMS CLASSIFICATION MANAGEMENT INFORMATION SYSTEM (MXEMIS

The importance of management information systems in a managed care environment.

PubMed

Porro, M R; Brill, K R

1995-06-01

Keys to successful information systems for home care providers are planning and control. With managed care's emphasis on data, agencies need to have information systems that can handle the demands managed care puts on agencies today--planning before hurrying to install a system will ensure control as the managed care contracts add up.

Use of electronic information systems in nursing management.

PubMed

Lammintakanen, Johanna; Saranto, Kaija; Kivinen, Tuula

2010-05-01

The purpose of this study is to describe nurse managers' perceptions of the use of electronic information systems in their daily work. Several kinds of software are used for administrative and information management purposes in health care organizations, but the issue has been studied less from nurse managers' perspective. The material for this qualitative study was acquired according to the principles of focus group interview. Altogether eight focus groups were held with 48 nurse managers from both primary and specialized health care organizations. The nurse managers were asked in focus groups to describe the use of information systems in their daily work in addition to some other themes. The material was analyzed by inductive content analysis using ATLAS.ti computer program. The main category "pros and cons of using information systems in nursing management" summarized the nurse managers' perceptions of using electronic information systems. The main category consisted of three sub-categories: (1) nurse managers' perceptions of the use of information technology; (2) usability of management information systems; (3) development of personnel competencies and work processes. The nurse managers made several comments on the implementation of immature electronic information systems which caused inefficiencies in working processes. However, they considered electronic information systems to be essential elements of their daily work. Furthermore, the nurse managers' descriptions of the pros and cons of using information systems reflected partly the shortcomings of strategic management and lack of coordination in health care organizations. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.

Knowledge-based systems for power management

NASA Technical Reports Server (NTRS)

Lollar, L. F.

1992-01-01

NASA-Marshall's Electrical Power Branch has undertaken the development of expert systems in support of further advancements in electrical power system automation. Attention is given to the features (1) of the Fault Recovery and Management Expert System, (2) a resource scheduler or Master of Automated Expert Scheduling Through Resource Orchestration, and (3) an adaptive load-priority manager, or Load Priority List Management System. The characteristics of an advisory battery manager for the Hubble Space Telescope, designated the 'nickel-hydrogen expert system', are also noted.

Toward information management in corporations (2)

NASA Astrophysics Data System (ADS)

Shibata, Mitsuru

If construction of inhouse information management systems in an advanced information society should be positioned along with the social information management, its base making begins with reviewing current paper filing systems. Since the problems which inhere in inhouse information management systems utilizing OA equipments also inhere in paper filing systems, the first step toward full scale inhouse information management should be to grasp and solve the fundamental problems in current filing systems. This paper describes analysis of fundamental problems in filing systems, making new type of offices and analysis of improvement needs in filing systems, and some points in improving filing systems.

75 FR 68418 - Real-Time System Management Information Program

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-08

...-Time System Management Information Program AGENCY: Federal Highway Administration (FHWA), DOT. ACTION...) to establish a Real-Time System Management Information Program that provides, in all States, the... traveler information. The purposes of the Real-Time System Management Information Program are to: (1...

20 CFR 633.311 - Management information systems.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Management information systems. 633.311... AND SEASONAL FARMWORKER PROGRAMS Program Design and Administrative Procedures § 633.311 Management information systems. All grantees shall establish and maintain a program and financial management system which...

76 FR 42536 - Real-Time System Management Information Program

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-19

...-Time System Management Information Program AGENCY: Federal Highway Administration (FHWA), DOT. ACTION... Real-Time System Management Information Program and general information about current and planned... establishing requirements for the Real-Time System Management Information Program on November 8, 2010, at 75 FR...

41 CFR 101-39.102 - Determinations.

Code of Federal Regulations, 2010 CFR

2010-07-01

...-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.1-Establishment, Modification, and Discontinuance of Interagency Fleet Management Systems § 101-39.102 Determinations. Each determination to establish a fleet management system... name of the executive agency designated to be responsible for operating the fleet management system and...

48 CFR 970.3270 - Standard financial management clauses.

Code of Federal Regulations, 2011 CFR

2011-10-01

... management and operating contracts with integrated accounting systems. (iv) The contracting officer shall... systems: (1) 970.5232-7, Financial management system. (2) 970.5232-8, Integrated accounting. (c) Any... management clauses. 970.3270 Section 970.3270 Federal Acquisition Regulations System DEPARTMENT OF ENERGY...

48 CFR 970.3270 - Standard financial management clauses.

Code of Federal Regulations, 2014 CFR

2014-10-01

... management and operating contracts with integrated accounting systems. (iv) The contracting officer shall... systems: (1) 970.5232-7, Financial management system. (2) 970.5232-8, Integrated accounting. (c) Any... management clauses. 970.3270 Section 970.3270 Federal Acquisition Regulations System DEPARTMENT OF ENERGY...

48 CFR 970.3270 - Standard financial management clauses.

Code of Federal Regulations, 2013 CFR

2013-10-01

... management and operating contracts with integrated accounting systems. (iv) The contracting officer shall... systems: (1) 970.5232-7, Financial management system. (2) 970.5232-8, Integrated accounting. (c) Any... management clauses. 970.3270 Section 970.3270 Federal Acquisition Regulations System DEPARTMENT OF ENERGY...

48 CFR 970.3270 - Standard financial management clauses.

Code of Federal Regulations, 2012 CFR

2012-10-01

... management and operating contracts with integrated accounting systems. (iv) The contracting officer shall... systems: (1) 970.5232-7, Financial management system. (2) 970.5232-8, Integrated accounting. (c) Any... management clauses. 970.3270 Section 970.3270 Federal Acquisition Regulations System DEPARTMENT OF ENERGY...

Selecting Data-Base Management Software for Microcomputers in Libraries and Information Units.

ERIC Educational Resources Information Center

Pieska, K. A. O.

1986-01-01

Presents a model for the evaluation of database management systems software from the viewpoint of librarians and information specialists. The properties of data management systems, database management systems, and text retrieval systems are outlined and compared. (10 references) (CLB)

20 CFR 633.311 - Management information systems.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Management information systems. 633.311... AND SEASONAL FARMWORKER PROGRAMS Program Design and Administrative Procedures § 633.311 Management information systems. All grantees shall establish and maintain a program and financial management system which...

20 CFR 633.311 - Management information systems.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 20 Employees' Benefits 3 2012-04-01 2012-04-01 false Management information systems. 633.311... AND SEASONAL FARMWORKER PROGRAMS Program Design and Administrative Procedures § 633.311 Management information systems. All grantees shall establish and maintain a program and financial management system which...

The SysMan monitoring service and its management environment

NASA Astrophysics Data System (ADS)

Debski, Andrzej; Janas, Ekkehard

1996-06-01

Management of modern information systems is becoming more and more complex. There is a growing need for powerful, flexible and affordable management tools to assist system managers in maintaining such systems. It is at the same time evident that effective management should integrate network management, system management and application management in a uniform way. Object oriented OSI management architecture with its four basic modelling concepts (information, organization, communication and functional models) together with widely accepted distribution platforms such as ANSA/CORBA, constitutes a reliable and modern framework for the implementation of a management toolset. This paper focuses on the presentation of concepts and implementation results of an object oriented management toolset developed and implemented within the framework of the ESPRIT project 7026 SysMan. An overview is given of the implemented SysMan management services including the System Management Service, Monitoring Service, Network Management Service, Knowledge Service, Domain and Policy Service, and the User Interface. Special attention is paid to the Monitoring Service which incorporates the architectural key entity responsible for event management. Its architecture and building components, especially filters, are emphasized and presented in detail.

41 CFR 101-30.101-13 - Management data.

Code of Federal Regulations, 2014 CFR

2014-07-01

....101-13 Section 101-30.101-13 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 30-FEDERAL CATALOG SYSTEM 30... to the individual agency's supply system for purposes of supply management as standardization, source...

41 CFR 101-30.101-13 - Management data.

Code of Federal Regulations, 2012 CFR

2012-07-01

....101-13 Section 101-30.101-13 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 30-FEDERAL CATALOG SYSTEM 30... to the individual agency's supply system for purposes of supply management as standardization, source...

41 CFR 101-30.101-13 - Management data.

Code of Federal Regulations, 2013 CFR

2013-07-01

....101-13 Section 101-30.101-13 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 30-FEDERAL CATALOG SYSTEM 30... to the individual agency's supply system for purposes of supply management as standardization, source...

Adapting inland fisheries management to a changing climate

USGS Publications Warehouse

Paukert, Craig P.; Glazer, Bob A.; Hansen, Gretchen J. A.; Irwin, Brian J.; Jacobson, Peter C.; Kershner, Jeffrey L.; Shuter, Brian J.; Whitney, James E.; Lynch, Abigail J.

2016-01-01

Natural resource decision makers are challenged to adapt management to a changing climate while balancing short-term management goals with long-term changes in aquatic systems. Adaptation will require developing resilient ecosystems and resilient management systems. Decision makers already have tools to develop or ensure resilient aquatic systems and fisheries such as managing harvest and riparian zones. Because fisheries management often interacts with multiple stakeholders, adaptation strategies involving fisheries managers and other partners focused on land use, policy, and human systems, coupled with long-term monitoring, are necessary for resilient systems. We show how agencies and organizations are adapting to a changing climate in Minnesota and Ontario lakes and Montana streams. We also present how the Florida Fish and Wildlife Commission created a management structure to develop adaptation strategies. These examples demonstrate how organizations and agencies can cope with climate change effects on fishes and fisheries through creating resilient management and ecological systems.

The Air Program Information Management System (APIMS)

DTIC Science & Technology

2011-11-02

Technology November 2, 2011 The Air Program Information Management System (APIMS) Frank Castaneda, III, P.E. APIMS Program Manager AFCEE/TDNQ APIMS...NOV 2011 2. REPORT TYPE 3. DATES COVERED 00-00-2011 to 00-00-2011 4. TITLE AND SUBTITLE The Air Program Information Management System (APIMS... Information   Management   System : Sustainability of  Enterprise air quality management system • Aspects and Impacts to Process • Auditing and Measurement

75 FR 75549 - Defense Federal Acquisition Regulation Supplement; Business Systems-Definition and Administration...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-03

... systems as accounting systems, estimating systems, purchasing systems, earned value management systems (EVMS), material management and accounting systems (MMAS), and property management systems. 2. DoD is... percent. 2. Accounting System Comment: A number of respondents expressed concern about the criteria to be...

Integrated, automated revenue management for managed care contracts.

PubMed

Burckhart, Kent

2002-04-01

Faced with increasing managed care penetration and declining net revenue in recent years, healthcare providers increasingly are emphasizing revenue management. To streamline processes and reduce costs in this area, many healthcare providers have implemented or are considering automated contract management systems. When selecting such a system, healthcare financial managers should make certain that the system can interface with both patient-accounting and decision-support systems of the organization. This integration enhances a healthcare provider's financial viability by providing integrated revenue-management capabilities to analyze projected performance of proposed managed care contracts and actual performance of existing contracts.

Proactive pavement asset management with climate change aspects

NASA Astrophysics Data System (ADS)

Zofka, Adam

2018-05-01

Pavement Asset Management System is a systematic and objective tool to manage pavement network based on the rational, engineering and economic principles. Once implemented and mature Pavement Asset Management System serves the entire range of users starting with the maintenance engineers and ending with the decision-makers. Such a system is necessary to coordinate agency management strategy including proactive maintenance. Basic inputs in the majority of existing Pavement Asset Management System approaches comprise the actual pavement inventory with associated construction history and condition, traffic information as well as various economical parameters. Some Pavement Management System approaches include also weather aspects which is of particular importance considering ongoing climate changes. This paper presents challenges in implementing the Pavement Asset Management System for those National Road Administrations that manage their pavement assets using more traditional strategies, e.g. worse-first approach. Special considerations are given to weather-related inputs and associated analysis to demonstrate the effects of climate change in a short- and long-term range. Based on the presented examples this paper concludes that National Road Administrations should account for the weather-related factors in their Pavement Management Systems as this has a significant impact on the system outcomes from the safety and economical perspective.

46 CFR 16.500 - Management Information System requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Management Information System requirements. 16.500 Section 16.500 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MERCHANT MARINE OFFICERS AND SEAMEN CHEMICAL TESTING Management Information System § 16.500 Management Information System requirements. (a...

23 CFR 500.109 - CMS.

Code of Federal Regulations, 2011 CFR

2011-04-01

.... Congestion management means the application of strategies to improve system performance and reliability by... SYSTEMS Management Systems § 500.109 CMS. (a) For purposes of this part, congestion means the level at... management system or process is a systematic and regionally accepted approach for managing congestion that...

23 CFR 500.109 - CMS.

Code of Federal Regulations, 2010 CFR

2010-04-01

.... Congestion management means the application of strategies to improve system performance and reliability by... SYSTEMS Management Systems § 500.109 CMS. (a) For purposes of this part, congestion means the level at... management system or process is a systematic and regionally accepted approach for managing congestion that...

20 CFR 632.32 - Financial management systems.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Financial management systems. 632.32 Section... Financial management systems. (a) Each Native American grantee, subgrantee and contractor shall maintain a financial management system which will provide accurate, current and complete disclosure of the financial...

14 CFR 152.303 - Financial management system.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Financial management system. 152.303... (CONTINUED) AIRPORTS AIRPORT AID PROGRAM Accounting and Reporting Requirements § 152.303 Financial management system. Each sponsor or planning agency shall establish and maintain a financial management system that...

23 CFR 500.109 - CMS.

Code of Federal Regulations, 2013 CFR

2013-04-01

... SYSTEMS Management Systems § 500.109 CMS. (a) For purposes of this part, congestion means the level at.... Congestion management means the application of strategies to improve system performance and reliability by... management system or process is a systematic and regionally accepted approach for managing congestion that...

23 CFR 500.109 - CMS.

Code of Federal Regulations, 2014 CFR

2014-04-01

... SYSTEMS Management Systems § 500.109 CMS. (a) For purposes of this part, congestion means the level at.... Congestion management means the application of strategies to improve system performance and reliability by... management system or process is a systematic and regionally accepted approach for managing congestion that...

23 CFR 500.109 - CMS.

Code of Federal Regulations, 2012 CFR

2012-04-01

... SYSTEMS Management Systems § 500.109 CMS. (a) For purposes of this part, congestion means the level at.... Congestion management means the application of strategies to improve system performance and reliability by... management system or process is a systematic and regionally accepted approach for managing congestion that...

7 CFR 246.13 - Financial management system.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 4 2014-01-01 2014-01-01 false Financial management system. 246.13 Section 246.13... State Agency Provisions § 246.13 Financial management system. (a) Disclosure of expenditures. The State agency shall maintain a financial management system which provides accurate, current and complete...

7 CFR 246.13 - Financial management system.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 4 2013-01-01 2013-01-01 false Financial management system. 246.13 Section 246.13... State Agency Provisions § 246.13 Financial management system. (a) Disclosure of expenditures. The State agency shall maintain a financial management system which provides accurate, current and complete...

7 CFR 246.13 - Financial management system.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 4 2012-01-01 2012-01-01 false Financial management system. 246.13 Section 246.13... State Agency Provisions § 246.13 Financial management system. (a) Disclosure of expenditures. The State agency shall maintain a financial management system which provides accurate, current and complete...

29 CFR 1470.20 - Standards for financial management systems.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 29 Labor 4 2013-07-01 2013-07-01 false Standards for financial management systems. 1470.20 Section... Post-Award Requirements Financial Administration § 1470.20 Standards for financial management systems... the restrictions and prohibitions of applicable statutes. (b) The financial management systems of...

29 CFR 1470.20 - Standards for financial management systems.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 29 Labor 4 2012-07-01 2012-07-01 false Standards for financial management systems. 1470.20 Section... Post-Award Requirements Financial Administration § 1470.20 Standards for financial management systems... the restrictions and prohibitions of applicable statutes. (b) The financial management systems of...

7 CFR 246.13 - Financial management system.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 4 2010-01-01 2010-01-01 false Financial management system. 246.13 Section 246.13... State Agency Provisions § 246.13 Financial management system. (a) Disclosure of expenditures. The State agency shall maintain a financial management system which provides accurate, current and complete...

20 CFR 632.32 - Financial management systems.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Financial management systems. 632.32 Section... Financial management systems. (a) Each Native American grantee, subgrantee and contractor shall maintain a financial management system which will provide accurate, current and complete disclosure of the financial...

14 CFR 152.303 - Financial management system.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Financial management system. 152.303... (CONTINUED) AIRPORTS AIRPORT AID PROGRAM Accounting and Reporting Requirements § 152.303 Financial management system. Each sponsor or planning agency shall establish and maintain a financial management system that...

46 CFR 16.500 - Management Information System requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 1 2013-10-01 2013-10-01 false Management Information System requirements. 16.500 Section 16.500 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MERCHANT MARINE OFFICERS AND SEAMEN CHEMICAL TESTING Management Information System § 16.500 Management Information System requirements. (a...

46 CFR 16.500 - Management Information System requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 1 2011-10-01 2011-10-01 false Management Information System requirements. 16.500 Section 16.500 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MERCHANT MARINE OFFICERS AND SEAMEN CHEMICAL TESTING Management Information System § 16.500 Management Information System requirements. (a...

46 CFR 16.500 - Management Information System requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 1 2014-10-01 2014-10-01 false Management Information System requirements. 16.500 Section 16.500 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MERCHANT MARINE OFFICERS AND SEAMEN CHEMICAL TESTING Management Information System § 16.500 Management Information System requirements. (a...

46 CFR 16.500 - Management Information System requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 1 2012-10-01 2012-10-01 false Management Information System requirements. 16.500 Section 16.500 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MERCHANT MARINE OFFICERS AND SEAMEN CHEMICAL TESTING Management Information System § 16.500 Management Information System requirements. (a...

Course Management Systems for Learning: Beyond Accidental Pedagogy

ERIC Educational Resources Information Center

McGee, Patricia; Carmean, Colleen; Jafari, Ali

2005-01-01

"Course Management Systems for Learning: Beyond Accidental Pedagogy" is a comprehensive overview of standards, practices and possibilities of course management systems in higher education. "Course Management Systems for Learning: Beyond Accidental Pedagogy" focuses on what the current knowledge is (in best practices, research, standards and…

A design for a new catalog manager and associated file management for the Land Analysis System (LAS)

NASA Technical Reports Server (NTRS)

Greenhagen, Cheryl

1986-01-01

Due to the larger number of different types of files used in an image processing system, a mechanism for file management beyond the bounds of typical operating systems is necessary. The Transportable Applications Executive (TAE) Catalog Manager was written to meet this need. Land Analysis System (LAS) users at the EROS Data Center (EDC) encountered some problems in using the TAE catalog manager, including catalog corruption, networking difficulties, and lack of a reliable tape storage and retrieval capability. These problems, coupled with the complexity of the TAE catalog manager, led to the decision to design a new file management system for LAS, tailored to the needs of the EDC user community. This design effort, which addressed catalog management, label services, associated data management, and enhancements to LAS applications, is described. The new file management design will provide many benefits including improved system integration, increased flexibility, enhanced reliability, enhanced portability, improved performance, and improved maintainability.

Rhode Island congestion management plan : executive summary

DOT National Transportation Integrated Search

1997-09-01

This document provides an overview of the Rhode Island Congestion Management System (CMS) program consisting of the following: Congestion Management System Plan; Incident Management Plan; and Intelligent Transportation System (ITS) Early Deployment P...

Case Studies of Ecological Integrative Information Systems: The Luquillo and Sevilleta Information Management Systems

NASA Astrophysics Data System (ADS)

San Gil, Inigo; White, Marshall; Melendez, Eda; Vanderbilt, Kristin

The thirty-year-old United States Long Term Ecological Research Network has developed extensive metadata to document their scientific data. Standard and interoperable metadata is a core component of the data-driven analytical solutions developed by this research network Content management systems offer an affordable solution for rapid deployment of metadata centered information management systems. We developed a customized integrative metadata management system based on the Drupal content management system technology. Building on knowledge and experience with the Sevilleta and Luquillo Long Term Ecological Research sites, we successfully deployed the first two medium-scale customized prototypes. In this paper, we describe the vision behind our Drupal based information management instances, and list the features offered through these Drupal based systems. We also outline the plans to expand the information services offered through these metadata centered management systems. We will conclude with the growing list of participants deploying similar instances.

The success of a management information system in health care - a case study from Finland.

PubMed

Kivinen, Tuula; Lammintakanen, Johanna

2013-02-01

The purpose of this article is to describe perspectives on information availability and information use among users of a management information system in one specialized health care organization. The management information system (MIS) is defined as the information system that provides management with information about financial and operational aspects of hospital management. The material for this qualitative case study was gathered by semi-structured interviews. The interviewees were purposefully selected from one specialized health care organization. The organization has developed its management information system in recent years. Altogether 13 front-line, middle and top-level managers were interviewed. The two themes discussed were information availability and information use. The data were analyzed using inductive content analysis using ATLAS.ti computer program. The main category "usage of management information system" consisted of four sub-categories: (1) system quality, (2) information quality, (3) use and user satisfaction and (4) development of information culture. There were many organizational and cultural aspects which influence the use of MIS in addition to factors concerning system usability and users. The connection between information culture and information use was recognized and the managers proposed numerous ways to increase the use of information in management work. The implementation and use of management information system did not seem to be planned as an essential tool in strategic information management in the health care organization studied. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Cancer Care Ontario and integrated cancer programs: portrait of a performance management system and lessons learned.

PubMed

Cheng, Siu Mee; Thompson, Leslee J

2006-01-01

A performance management system has been implemented by Cancer Care Ontario (CCO). This system allows for the monitoring and management of 11 integrated cancer programs (ICPs) across the Province of Ontario. The system comprises of four elements: reporting frequency, reporting requirements, review meetings and accountability and continuous improvement activities. CCO and the ICPs have recently completed quarterly performance review exercises for the last two quarters of the fiscal year 2004-2005. The purpose of this paper is to address some of the key lessons learned. The paper provides an outline of the CCO performance management system. These lessons included: data must be valid and reliable; performance management requires commitments from both parties in the performance review exercises; streamlining performance reporting is beneficial; technology infrastructure which allows for cohesive management of data is vital for a sustainable performance management system; performance indicators need to stand up to scrutiny by both parties; and providing comparative data across the province is valuable. Critical success factors which would help to ensure a successful performance management system include: corporate engagement from various parts of an organization in the review exercises; desire to focus on performance improvement and avoidance of blaming; and strong data management systems. The performance management system is a practical and sustainable system that allows for performance improvement of cancer care services. It can be a vital tool to enhance accountability within the health care system. The paper demonstrates that the performance management system supports accountability in the cancer care system for Ontario, and reflects the principles of the provincial governments commitment to continuous improvement of healthcare.

Department of Defense Healthcare Management System Modernization (DHMSM)

DTIC Science & Technology

2016-03-01

2016 Major Automated Information System Annual Report Department of Defense Healthcare Management System Modernization (DHMSM) Defense...DSN Fax: Date Assigned: November 16, 2015 Program Information Program Name Department of Defense Healthcare Management System Modernization...DHMSM) DoD Component DoD The acquiring DoD Component is Program Executive Office (PEO) Department of Defense (DoD) Healthcare Management Systems (DHMS

Management Information Systems, Planning, and Public Community Colleges.

ERIC Educational Resources Information Center

Ritch, Stephen W.; Munro, Robert J.

Management Information Systems (MIS), originally developed in the areas of accounting, management science, and computer processing, are now being applied to decision-making in educational settings. Definitions of MIS are numerous and often vague, but management systems (as distinguished from other information systems) should promote real-time…

Advanced Grid Control Technologies Workshop Series | Energy Systems

Science.gov Websites

on advanced distribution management systems (ADMS) and microgrid controls. The workshops were held at . July 7, 2015: Advanced Distribution Management Systems (ADMS) Welcome and NREL Overview Dr. Murali Keynote: Next-Generation Distribution Management Systems and Distributed Resource Energy Management

20 CFR 437.20 - Standards for financial management systems.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Standards for financial management systems... Financial Administration § 437.20 Standards for financial management systems. (a) A State must expend and... of applicable statutes. (b) The financial management systems of other grantees and subgrantees must...

45 CFR 92.20 - Standards for financial management systems.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 1 2011-10-01 2011-10-01 false Standards for financial management systems. 92.20...-Award Requirements Financial Administration § 92.20 Standards for financial management systems. (a) A... restrictions and prohibitions of applicable statutes. (b) The financial management systems of other grantees...

14 CFR 1273.20 - Standards for financial management systems.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Standards for financial management systems... Requirements Financial Administration § 1273.20 Standards for financial management systems. (a) A State must... prohibitions of applicable statutes. (b) The financial management systems of other grantees and subgrantees...

45 CFR 92.20 - Standards for financial management systems.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 1 2014-10-01 2014-10-01 false Standards for financial management systems. 92.20...-Award Requirements Financial Administration § 92.20 Standards for financial management systems. (a) A... restrictions and prohibitions of applicable statutes. (b) The financial management systems of other grantees...

20 CFR 437.20 - Standards for financial management systems.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false Standards for financial management systems... Financial Administration § 437.20 Standards for financial management systems. (a) A State must expend and... of applicable statutes. (b) The financial management systems of other grantees and subgrantees must...

14 CFR 1273.20 - Standards for financial management systems.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Standards for financial management systems... Requirements Financial Administration § 1273.20 Standards for financial management systems. (a) A State must... prohibitions of applicable statutes. (b) The financial management systems of other grantees and subgrantees...

20 CFR 437.20 - Standards for financial management systems.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false Standards for financial management systems... Financial Administration § 437.20 Standards for financial management systems. (a) A State must expend and... of applicable statutes. (b) The financial management systems of other grantees and subgrantees must...

20 CFR 437.20 - Standards for financial management systems.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false Standards for financial management systems... Financial Administration § 437.20 Standards for financial management systems. (a) A State must expend and... of applicable statutes. (b) The financial management systems of other grantees and subgrantees must...

14 CFR § 1273.20 - Standards for financial management systems.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Standards for financial management systems... Post-Award Requirements Financial Administration § 1273.20 Standards for financial management systems... the restrictions and prohibitions of applicable statutes. (b) The financial management systems of...

49 CFR 19.21 - Standards for financial management systems.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false Standards for financial management systems. 19.21... ORGANIZATIONS Post-Award Requirements § 19.21 Standards for financial management systems. (a) Federal awarding... information whenever practical. (b) Recipients' financial management systems shall provide for the following...

14 CFR 1260.121 - Standards for financial management systems.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Standards for financial management systems... Requirements § 1260.121 Standards for financial management systems. (a) Recipients shall relate financial data...) Recipients' financial management systems shall provide for the following. (1) Accurate, current and complete...

7 CFR 550.20 - Standards for financial management systems.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 6 2010-01-01 2010-01-01 false Standards for financial management systems. 550.20... Management of Agreements Financial Management § 550.20 Standards for financial management systems. (a) REE agencies shall require Cooperators to relate financial data to performance data. (b) Cooperators' financial...

41 CFR 101-39.200 - Scope.

Code of Federal Regulations, 2010 CFR

2010-07-01

... MANAGEMENT SYSTEMS 39.2-GSA Interagency Fleet Management System Services § 101-39.200 Scope. This subpart... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Scope. 101-39.200 Section 101-39.200 Public Contracts and Property Management Federal Property Management Regulations System...

41 CFR 101-39.200 - Scope.

Code of Federal Regulations, 2011 CFR

2011-07-01

... MANAGEMENT SYSTEMS 39.2-GSA Interagency Fleet Management System Services § 101-39.200 Scope. This subpart... 41 Public Contracts and Property Management 2 2011-07-01 2007-07-01 true Scope. 101-39.200 Section 101-39.200 Public Contracts and Property Management Federal Property Management Regulations System...

41 CFR 101-39.200 - Scope.

Code of Federal Regulations, 2014 CFR

2014-07-01

... MANAGEMENT SYSTEMS 39.2-GSA Interagency Fleet Management System Services § 101-39.200 Scope. This subpart... 41 Public Contracts and Property Management 2 2014-07-01 2012-07-01 true Scope. 101-39.200 Section 101-39.200 Public Contracts and Property Management Federal Property Management Regulations System...

76 FR 47516 - Personnel Management in Agencies

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-05

... management, in accordance with merit system principles. Sec. 250.205 Systems and standards. The five human... effective human capital management in accordance with the merit system principles and in compliance with... OFFICE OF PERSONNEL MANAGEMENT 5 CFR PART 250 RIN 3206-AL98 Personnel Management in Agencies...

40 CFR 30.21 - Standards for financial management systems.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Standards for financial management... Program Management § 30.21 Standards for financial management systems. (a) EPA shall require recipients to...) Recipients' financial management systems shall provide for the following. (1) Accurate, current and complete...

32 CFR 34.11 - Standards for financial management systems.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 1 2010-07-01 2010-07-01 false Standards for financial management systems. 34... ORGANIZATIONS Post-award Requirements Financial and Program Management § 34.11 Standards for financial management systems. (a) Recipients shall be allowed and encouraged to use existing financial management...

41 CFR 105-72.301 - Standards for financial management systems.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Standards for financial... Management § 105-72.301 Standards for financial management systems. (a) Federal awarding agencies shall... practical. (b) Recipients' financial management systems shall provide for the following. (1) Accurate...

7 CFR 550.20 - Standards for financial management systems.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 6 2011-01-01 2011-01-01 false Standards for financial management systems. 550.20... Management of Agreements Financial Management § 550.20 Standards for financial management systems. (a) REE agencies shall require Cooperators to relate financial data to performance data. (b) Cooperators' financial...

Design and realization of high quality prime farmland planning and management information system

NASA Astrophysics Data System (ADS)

Li, Manchun; Liu, Guohong; Liu, Yongxue; Jiang, Zhixin

2007-06-01

The article discusses the design and realization of a high quality prime farmland planning and management information system based on SDSS. Models in concept integration, management planning are used in High Quality Prime Farmland Planning in order to refine the current model system and the management information system is deigned with a triangular structure. Finally an example of Tonglu county high quality prime farmland planning and management information system is introduced.

Navy Occupational Health Information Management System (NOHIMS). System-Wide Module. Program Maintenance Manual

DTIC Science & Technology

1987-06-01

NAVY OCCUPATIONAL HEALTH INFORMATION MANAGEMENT SYSTEM NOHIMS SYSTEM-WIDE MODULE PROGRAM MAINTENANCE MANUAL JUNE 1987 DTIC 00 SEP I 21988DJ 0) 4... INFORMATION MANAGEMENT SYSTEM (NOHIMS) N 1.98 SYSTEM-WIDE MODULE PROGRAM MAINTENANCE MANUAL 7. Author(s) a. Performing Organization Rapt. No. MITRE... Management System (NOHIMS). NORIMS, whose initial version was ,eveloped at the Naval Health Research Center (NHRC), is a composite of 4 -’o subsystems: an

A new specimen management system using RFID technology.

PubMed

Shim, Hun; Uh, Young; Lee, Seung Hwan; Yoon, Young Ro

2011-12-01

The specimen management system with barcode needs to be improved in order to solve inherent problems in work performance. This study describes the application of Radio Frequency Identification (RFID) which is the solution for the problems associated with specimen labeling and management. A new specimen management system and architecture with RFID technology for clinical laboratory was designed. The suggested system was tested in various conditions such as durability to temperature and aspect of effective utilization of new work flow under a virtual hospital clinical laboratory environment. This system demonstrates its potential application in clinical laboratories for improving work flow and specimen management. The suggested specimen management system with RFID technology has advantages in comparison to the traditional specimen management system with barcode in the aspect of mass specimen processing, robust durability of temperature, humidity changes, and effective specimen tracking.

Organizational technologies of chronic disease management programs in large rural multispecialty group practice systems.

PubMed

Gamm, Larry; Bolin, Jane Nelson; Kash, Bita A

2005-01-01

Four large rural multispecialty group practice systems employ a mix of organizational technologies to provide chronic disease management with measurable impacts on their patient populations and costs. Four technologies-administrative, clinical, information, and social-are proposed as key dimensions for examining disease management programs. The benefits of disease management are recognized by these systems despite marked variability in the organization of the programs. Committees spanning health plans and clinics in the 4 systems and electronic medical records and/or other disease management information systems are important coordinating mechanisms. Increased reliance on nurses for patient education and care coordination in all 4 systems reflects significant extension of clinical and social technologies in the management of patient care. The promise of disease management as offered by these systems and other auspices are considered.

Distributed Information System Development: Review of Some Management Issues

NASA Astrophysics Data System (ADS)

Mishra, Deepti; Mishra, Alok

Due to the proliferation of the Internet and globalization, distributed information system development is becoming popular. In this paper we have reviewed some significant management issues like process management, project management, requirements management and knowledge management issues which have received much attention in distributed development perspective. In this literature review we found that areas like quality and risk management issues could get only scant attention in distributed information system development.

Recommendation System Based On Association Rules For Distributed E-Learning Management Systems

NASA Astrophysics Data System (ADS)

Mihai, Gabroveanu

2015-09-01

Traditional Learning Management Systems are installed on a single server where learning materials and user data are kept. To increase its performance, the Learning Management System can be installed on multiple servers; learning materials and user data could be distributed across these servers obtaining a Distributed Learning Management System. In this paper is proposed the prototype of a recommendation system based on association rules for Distributed Learning Management System. Information from LMS databases is analyzed using distributed data mining algorithms in order to extract the association rules. Then the extracted rules are used as inference rules to provide personalized recommendations. The quality of provided recommendations is improved because the rules used to make the inferences are more accurate, since these rules aggregate knowledge from all e-Learning systems included in Distributed Learning Management System.

41 CFR 101-1.109 - Numbering in FPMR System.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Numbering in FPMR System. 101-1.109 Section 101-1.109 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS GENERAL 1-INTRODUCTION 1.1-Regulation System § 101...

41 CFR 101-1.105 - Authority for FPMR System.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Authority for FPMR System. 101-1.105 Section 101-1.105 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS GENERAL 1-INTRODUCTION 1.1-Regulation System § 101...

78 FR 12344 - Wekiva River System Advisory Management Committee Meetings (FY2013)

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-22

... River System Advisory Management Committee. DATES: The meetings are scheduled for: April 3, 2013; June 4... meeting will result in decisions and steps that advance the Wekiva River System Advisory Management... Wekiva River System Advisory Management Committee, National Park Service, 5342 Clark Road, PMB 123...

20 CFR 627.425 - Standards for financial management and participant data systems.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Standards for financial management and... Administrative Standards § 627.425 Standards for financial management and participant data systems. (a)(1) General. The financial management system and the participant data system of each recipient and...

41 CFR 109-27.102-50 - Systems contracting.

Code of Federal Regulations, 2010 CFR

2010-07-01

...-INVENTORY MANAGEMENT 27.1-Stock Replenishment § 109-27.102-50 Systems contracting. Systems contracting may... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Systems contracting. 109-27.102-50 Section 109-27.102-50 Public Contracts and Property Management Federal Property Management...

78 FR 71036 - Pipeline Safety: Random Drug Testing Rate; Contractor Management Information System Reporting...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-27

... PHMSA-2013-0248] Pipeline Safety: Random Drug Testing Rate; Contractor Management Information System Reporting; and Obtaining Drug and Alcohol Management Information System Sign-In Information AGENCY: Pipeline... Management Information System (MIS) Data; and New Method for Operators to Obtain User Name and Password for...

40 CFR 35.6270 - Standards for financial management systems.

Code of Federal Regulations, 2011 CFR

2011-07-01

... § 35.6270 Standards for financial management systems. (a) Accounting system standards—(1) General. The... of the adequacy of the financial management system as described in 40 CFR 31.20(c). (2) Allowable... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Standards for financial management...

7 CFR 277.6 - Standards for financial management systems.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 4 2011-01-01 2011-01-01 false Standards for financial management systems. 277.6... ADMINISTRATIVE COSTS OF STATE AGENCIES § 277.6 Standards for financial management systems. (a) General. This section prescribes standards for financial management systems in administering program funds by the State...

48 CFR 252.242-7004 - Material Management and Accounting System.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Material Management and... CLAUSES Text of Provisions And Clauses 252.242-7004 Material Management and Accounting System. As prescribed in 242.7204, use the following clause: Material Management and Accounting System (MAY 2011) (a...

48 CFR 252.234-7002 - Earned Value Management System.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Earned Value Management... of Provisions And Clauses 252.234-7002 Earned Value Management System. As prescribed in 234.203(2), use the following clause: Earned Value Management System (MAY 2011) (a) Definitions. As used in this...

48 CFR 252.234-7002 - Earned Value Management System.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Earned Value Management... of Provisions And Clauses 252.234-7002 Earned Value Management System. As prescribed in 234.203(2), use the following clause: Earned Value Management System (MAY 2011) (a) Definitions. As used in this...

48 CFR 252.242-7004 - Material Management and Accounting System.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Material Management and... CLAUSES Text of Provisions And Clauses 252.242-7004 Material Management and Accounting System. As prescribed in 242.7204, use the following clause: Material Management and Accounting System (MAY 2011) (a...

48 CFR 252.234-7002 - Earned Value Management System.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Earned Value Management... of Provisions And Clauses 252.234-7002 Earned Value Management System. As prescribed in 234.203(2), use the following clause: Earned Value Management System (MAY 2011) (a) Definitions. As used in this...

48 CFR 252.242-7004 - Material Management and Accounting System.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Material Management and... CLAUSES Text of Provisions And Clauses 252.242-7004 Material Management and Accounting System. As prescribed in 242.7204, use the following clause: Material Management and Accounting System (MAY 2011) (a...

33 CFR 96.250 - What documents and reports must a safety management system have?

Code of Federal Regulations, 2010 CFR

2010-07-01

...) Safety management system document and data maintenance (1) Procedures which establish and maintain control of all documents and data relevant to the safety management system. (2) Documents are available at... safety management system have? 96.250 Section 96.250 Navigation and Navigable Waters COAST GUARD...

33 CFR 96.240 - What functional requirements must a safety management system meet?

Code of Federal Regulations, 2010 CFR

2010-07-01

... a safety management system meet? 96.240 Section 96.240 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY VESSEL OPERATING REGULATIONS RULES FOR THE SAFE OPERATION OF VESSELS AND SAFETY MANAGEMENT SYSTEMS Company and Vessel Safety Management Systems § 96.240 What functional...

33 CFR 96.230 - What objectives must a safety management system meet?

Code of Federal Regulations, 2010 CFR

2010-07-01

... management system meet? 96.230 Section 96.230 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY VESSEL OPERATING REGULATIONS RULES FOR THE SAFE OPERATION OF VESSELS AND SAFETY MANAGEMENT SYSTEMS Company and Vessel Safety Management Systems § 96.230 What objectives must a safety...

22 CFR 135.20 - Standards for financial management systems.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Standards for financial management systems. 135... Financial Administration § 135.20 Standards for financial management systems. (a) A State must expand and... of applicable statutes. (b) The financial management systems of other grantees and subgrantees must...

36 CFR 1207.20 - Standards for financial management systems.

Code of Federal Regulations, 2011 CFR

2011-07-01

... management systems. 1207.20 Section 1207.20 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS... financial management systems. (a) A State must expand and account for grant funds in accordance with State... management systems of other grantees and subgrantees must meet the following standards: (1) Financial...

32 CFR 33.20 - Standards for financial management systems.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 1 2011-07-01 2011-07-01 false Standards for financial management systems. 33... financial management systems. (a) A State must expand and account for grant funds in accordance with State... management systems of other grantees and subgrantees must meet the following standards: (1) Financial...

21 CFR 1403.20 - Standards for financial management systems.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 9 2011-04-01 2011-04-01 false Standards for financial management systems. 1403... Financial Administration § 1403.20 Standards for financial management systems. (a) A State must expend and... of applicable statutes. (b) The financial management systems of other grantees and subgrantees must...

38 CFR 43.20 - Standards for financial management systems.

Code of Federal Regulations, 2011 CFR

2011-07-01

... management systems. 43.20 Section 43.20 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS... management systems. (a) A State must expand and account for grant funds in accordance with State laws and... violation of the restrictions and prohibitions of applicable statutes. (b) The financial management systems...

21 CFR 1403.20 - Standards for financial management systems.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 9 2013-04-01 2013-04-01 false Standards for financial management systems. 1403... Financial Administration § 1403.20 Standards for financial management systems. (a) A State must expend and... of applicable statutes. (b) The financial management systems of other grantees and subgrantees must...

49 CFR 18.20 - Standards for financial management systems.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 1 2014-10-01 2014-10-01 false Standards for financial management systems. 18.20... Administration § 18.20 Standards for financial management systems. (a) A State must expand and account for grant... statutes. (b) The financial management systems of other grantees and subgrantees must meet the following...

21 CFR 1403.20 - Standards for financial management systems.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 9 2012-04-01 2012-04-01 false Standards for financial management systems. 1403... Financial Administration § 1403.20 Standards for financial management systems. (a) A State must expend and... of applicable statutes. (b) The financial management systems of other grantees and subgrantees must...

36 CFR § 1207.20 - Standards for financial management systems.

Code of Federal Regulations, 2013 CFR

2013-07-01

... management systems. § 1207.20 Section § 1207.20 Parks, Forests, and Public Property NATIONAL ARCHIVES AND... Standards for financial management systems. (a) A State must expand and account for grant funds in... financial management systems of other grantees and subgrantees must meet the following standards: (1...

38 CFR 43.20 - Standards for financial management systems.

Code of Federal Regulations, 2014 CFR

2014-07-01

... management systems. 43.20 Section 43.20 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS... management systems. (a) A State must expand and account for grant funds in accordance with State laws and... violation of the restrictions and prohibitions of applicable statutes. (b) The financial management systems...

10 CFR 600.220 - Standards for financial management systems.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false Standards for financial management systems. 600.220... Post-Award Requirements § 600.220 Standards for financial management systems. (a) A State must expend... prohibitions of applicable statutes. (b) The financial management systems of other grantees and subgrantees...

45 CFR 1174.20 - Standards for financial management systems.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 3 2012-10-01 2012-10-01 false Standards for financial management systems. 1174... Financial Administration § 1174.20 Standards for financial management systems. (a) A State must expand and... of applicable statutes. (b) The financial management systems of other grantees and subgrantees must...

45 CFR 1183.20 - Standards for financial management systems.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 3 2012-10-01 2012-10-01 false Standards for financial management systems. 1183... Financial Administration § 1183.20 Standards for financial management systems. (a) A State must expand and... of applicable statutes. (b) The financial management systems of other grantees and subgrantees must...

45 CFR 1157.20 - Standards for financial management systems.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 3 2013-10-01 2013-10-01 false Standards for financial management systems. 1157... Administration § 1157.20 Standards for financial management systems. (a) A State must expand and account for... statutes. (b) The financial management systems of other grantees and subgrantees must meet the following...

22 CFR 135.20 - Standards for financial management systems.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Standards for financial management systems. 135... Financial Administration § 135.20 Standards for financial management systems. (a) A State must expand and... of applicable statutes. (b) The financial management systems of other grantees and subgrantees must...

43 CFR 12.60 - Standards for financial management systems.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false Standards for financial management systems... Standards for financial management systems. (a) A State must expand and account for grant funds in... financial management systems of other grantees and subgrantees must meet the following standards: (1...

49 CFR 18.20 - Standards for financial management systems.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 1 2012-10-01 2012-10-01 false Standards for financial management systems. 18.20... Administration § 18.20 Standards for financial management systems. (a) A State must expand and account for grant... statutes. (b) The financial management systems of other grantees and subgrantees must meet the following...

38 CFR 43.20 - Standards for financial management systems.

Code of Federal Regulations, 2012 CFR

2012-07-01

... management systems. 43.20 Section 43.20 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS... management systems. (a) A State must expand and account for grant funds in accordance with State laws and... violation of the restrictions and prohibitions of applicable statutes. (b) The financial management systems...

45 CFR 1174.20 - Standards for financial management systems.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 3 2013-10-01 2013-10-01 false Standards for financial management systems. 1174... Financial Administration § 1174.20 Standards for financial management systems. (a) A State must expand and... of applicable statutes. (b) The financial management systems of other grantees and subgrantees must...

10 CFR 600.220 - Standards for financial management systems.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Standards for financial management systems. 600.220... Post-Award Requirements § 600.220 Standards for financial management systems. (a) A State must expend... prohibitions of applicable statutes. (b) The financial management systems of other grantees and subgrantees...

48 CFR 52.204-13 - System for Award Management Maintenance.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Management Maintenance. 52.204-13 Section 52.204-13 Federal Acquisition Regulations System FEDERAL... Provisions and Clauses 52.204-13 System for Award Management Maintenance. As prescribed in 4.1105(b), use the following clause: System for Award Management Maintenance (JUL 2013) (a) Definitions. As used in this clause...

38 CFR 43.20 - Standards for financial management systems.

Code of Federal Regulations, 2013 CFR

2013-07-01

... management systems. 43.20 Section 43.20 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS... management systems. (a) A State must expand and account for grant funds in accordance with State laws and... violation of the restrictions and prohibitions of applicable statutes. (b) The financial management systems...

36 CFR 1207.20 - Standards for financial management systems.

Code of Federal Regulations, 2012 CFR

2012-07-01

... management systems. 1207.20 Section 1207.20 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS... financial management systems. (a) A State must expand and account for grant funds in accordance with State... management systems of other grantees and subgrantees must meet the following standards: (1) Financial...

36 CFR 1207.20 - Standards for financial management systems.

Code of Federal Regulations, 2014 CFR

2014-07-01

... management systems. 1207.20 Section 1207.20 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS... financial management systems. (a) A State must expand and account for grant funds in accordance with State... management systems of other grantees and subgrantees must meet the following standards: (1) Financial...