Mercury MESSENGER Stamp Unveiling

NASA Image and Video Library

2011-05-03

United States Postal Service Vice President of Finance Steve Masse, left, and NASA Mercury Astronaut Scott Carpenter, unveil two USPS stamps to commemorate and celebrate 50 years of US Spaceflight and the MESSENGER program during an event, Wednesday, May 4, 2011 at the NASA Kennedy Space Center in Cape Canaveral, Fla. One stamp commemorates NASA’s Project Mercury, America’s first manned spaceflight program, and NASA astronaut Alan Shepard’s historic flight on May 5, 1961, aboard spacecraft Freedom 7. The other stamp draws attention to NASA’s unmanned MESSENGER mission, a scientific investigation of the planet Mercury. On March 17, 2011, MESSENGER became the first spacecraft to enter into orbit around Mercury. Photo Credit: (NASA/Bill Ingalls)

Mercury MESSENGER Stamp Unveiling

NASA Image and Video Library

2011-05-03

Daughters of NASA astronaut Alan Shepard, Laura Shepard Churchley, left, Alice Wackermann and Julie Jenkins, right, speak during an unveiling ceremony of two USPS stamps that commemorate and celebrate 50 years of US Spaceflight and the MESSENGER program during an event, Wednesday, May 4, 2011 at the NASA Kennedy Space Center in Cape Canaveral, Fla. One stamp commemorates NASA’s Project Mercury, America’s first manned spaceflight program, and NASA astronaut Alan Shepard’s historic flight on May 5, 1961, aboard spacecraft Freedom 7. The other stamp draws attention to NASA’s unmanned MESSENGER mission, a scientific investigation of the planet Mercury. On March 17, 2011, MESSENGER became the first spacecraft to enter into orbit around Mercury. Photo Credit: (NASA/Bill Ingalls)

THE HAZARD OF CORPUSCULAR SOLAR RADIATION TO MANNED SPACEFLIGHT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Waddington, C.J.

BS>The presently available data on the storms'' of solar particles are used to compute the radiation dose that would be received by astronauts shielded by different thicknesses of material. It is shown that at least some of these storms represent a severe hazard to successful manned spaceflights. (auth)

Intelligent Systems Technologies for Ops

NASA Technical Reports Server (NTRS)

Smith, Ernest E.; Korsmeyer, David J.

2012-01-01

As NASA supports International Space Station assembly complete operations through 2020 (or later) and prepares for future human exploration programs, there is additional emphasis in the manned spaceflight program to find more efficient and effective ways of providing the ground-based mission support. Since 2006 this search for improvement has led to a significant cross-fertilization between the NASA advanced software development community and the manned spaceflight operations community. A variety of mission operations systems and tools have been developed over the past decades as NASA has operated the Mars robotic missions, the Space Shuttle, and the International Space Station. NASA Ames Research Center has been developing and applying its advanced intelligent systems research to mission operations tools for both unmanned Mars missions operations since 2001 and to manned operations with NASA Johnson Space Center since 2006. In particular, the fundamental advanced software development work under the Exploration Technology Program, and the experience and capabilities developed for mission operations systems for the Mars surface missions, (Spirit/Opportunity, Phoenix Lander, and MSL) have enhanced the development and application of advanced mission operation systems for the International Space Station and future spacecraft. This paper provides an update on the status of the development and deployment of a variety of intelligent systems technologies adopted for manned mission operations, and some discussion of the planned work for Autonomous Mission Operations in future human exploration. We discuss several specific projects between the Ames Research Center and the Johnson Space Centers Mission Operations Directorate, and how these technologies and projects are enhancing the mission operations support for the International Space Station, and supporting the current Autonomous Mission Operations Project for the mission operation support of the future human exploration programs.

Mercury MESSENGER Stamp Unveiling

NASA Image and Video Library

2011-05-03

Daughters of NASA astronaut Alan Shepard, Laura Shepard Churchley, standing left, Alice Wackermann and Julie Jenkins, standing right, speak during an unveiling ceremony of two USPS stamps that commemorate and celebrate 50 years of US Spaceflight and the MESSENGER program during an event, Wednesday, May 4, 2011 at the NASA Kennedy Space Center in Cape Canaveral, Fla. One stamp commemorates NASA’s Project Mercury, America’s first manned spaceflight program, and NASA astronaut Alan Shepard’s historic flight on May 5, 1961, aboard spacecraft Freedom 7. The other stamp draws attention to NASA’s unmanned MESSENGER mission, a scientific investigation of the planet Mercury. On March 17, 2011, MESSENGER became the first spacecraft to enter into orbit around Mercury. Photo Credit: (NASA/Bill Ingalls)

Mission to Mars: food production and processing for the final frontier.

PubMed

Perchonok, Michele H; Cooper, Maya R; Catauro, Patricia M

2012-01-01

The food systems of the National Aeronautics and Space Administration (NASA) have evolved tremendously since the early manned spaceflights of the 1960s. To date, NASA's mission focus has been limited to exploration of low Earth orbit (LEO), and the agency's prepackaged food systems have been adequate to enable success of their parent programs. With NASA's mission focus increasing to achieve manned space exploration of the Martian surface, the agency is considering a significant departure from the prepackaged food systems of current and past space programs. NASA's Advanced Food Technology (AFT) project is presently investigating the introduction of a bioregenerative food system to support long duration habitat missions to the Martian surface. A bioregenerative food system is expected to impart less of a burden on critical mission resources, such as mass and volume, than a prepackaged, shelf-stable system. This review provides an introduction to past and present spaceflight food systems, and provides a broad examination of the research conducted to date to enable crop production and food processing on the Martian surface.

Current status and future direction of NASA's Space Life Sciences Program

NASA Technical Reports Server (NTRS)

White, Ronald J.; Lujan, Barbara F.

1989-01-01

The elements of the NASA Life Sciences Program that are related to manned space flight and biological scientific studies in space are reviewed. Projects included in the current program are outlined and the future direction of the program is discussed. Consideration is given to issues such as long-duration spaceflight, medical support in space, readaptation to the gravity field of earth, considerations for the Space Station, radiation hazards, environmental standards for space habitation, and human operator interaction with computers, robots, and telepresence systems.

Animals and spaceflight: from survival to understanding.

PubMed

Morey-Holton, E R; Hill, E L; Souza, K A

2007-01-01

Animals have been a critical component of the spaceflight program since its inception. The Russians orbited a dog one month after the Sputnik satellite was launched. The dog mission spurred U.S. interest in animal flights. The animal missions proved that individuals aboard a spacecraft not only could survive, but also could carry out tasks during launch, near-weightlessness, and re-entry; humans were launched into space only after the early animal flights demonstrated that spaceflight was safe and survivable. After these humble beginnings when animals preceded humans in space as pioneers, a dynamic research program was begun using animals as human surrogates aboard manned and unmanned space platforms to understand how the unique environment of space alters life. In this review article, the following questions have been addressed: How did animal research in space evolve? What happened to animal development when gravity decreased? How have animal experiments in space contributed to our understanding of musculoskeletal changes and fracture repair during exposure to reduced gravity?

Human Adaptation to Space: Space Physiology and Countermeasures

NASA Technical Reports Server (NTRS)

Fogarty, Jennifer

2009-01-01

This viewgraph presentation reviews human physiological responses to spaceflight, and the countermeasures taken to prevent adverse effects of manned space flight. The topics include: 1) Human Spaceflight Experience; 2) Human Response to Spaceflight; 3) ISS Expeditions 1-16; 4) Countermeasure; and 5) Biomedical Data;

Spaceflight and bone turnover - Correlation with a new rat model of weightlessness

NASA Technical Reports Server (NTRS)

Morey, E. R.

1979-01-01

Earlier manned spaceflight studies have revealed that the near-weightless environment of orbital flight produce certain biological effects in humans, including abnormalities in mineral metabolism. The data collected were compatible with bone mineral loss. Cosmos 782 and 936 experiments have shown a decrease in rat bone formation rate. In this paper, a rat model of weightlessness is described, which is unique in that the animal is free to move about a 360-deg arc. The model meets the requirements for an acceptable system. Data from the model and spaceflight are presented. Many of the responses noted in suspended animals indicate that the model closely mimics results from rats and man exposed to near-weightlessness during orbital spaceflight.

Mercury MESSENGER Stamp Unveiling

NASA Image and Video Library

2011-05-03

Patty Carpenter, wife of NASA Mercury Astronaut Scott Carpenter, left, Daughters of NASA astronaut Alan Shepard, Laura Shepard Churchley, and, Alice Wackermann, right, sing the National Anthem during an unveiling ceremony of two USPS stamps that commemorate and celebrate 50 years of US Spaceflight and the MESSENGER program during an event, Wednesday, May 4, 2011 at the NASA Kennedy Space Center in Cape Canaveral, Fla. One stamp commemorates NASA’s Project Mercury, America’s first manned spaceflight program, and NASA astronaut Alan Shepard’s historic flight on May 5, 1961, aboard spacecraft Freedom 7. The other stamp draws attention to NASA’s unmanned MESSENGER mission, a scientific investigation of the planet Mercury. On March 17, 2011, MESSENGER became the first spacecraft to enter into orbit around Mercury. Photo Credit: (NASA/Bill Ingalls)

Project Mercury: NASA's first manned space programme

NASA Astrophysics Data System (ADS)

Catchpole, John

Project Mercury will offer a developmental resume of the first American manned spaceflight programme and its associated infrastructure, including accounts of space launch vehicles. The book highlights the differences in Redstone/Atlas technology, drawing similar comparisons between ballistic capsules and alternative types of spacecraft. The book also covers astronaut selection and training, as well as tracking systems, flight control, basic principles of spaceflight and detailed accounts of individual flights.

Expedition 19 Docks to ISS

NASA Image and Video Library

2009-03-27

Alexei Krasnov, Director of Manned Space Programs Department, Roscosmos, answers reporters questions during a Soyuz post-docking press conference at the Russian mission Control Center in Korolev, Russia on Saturday March 28, 2009. The Soyuz TMA-14 docked to the International Space Station carrying Expedition 19 Commander Gennady I. Padalka, Flight Engineer Michael R. Barratt and Spaceflight Participant Charles Simonyi. Photo Credit: (NASA/Bill Ingalls)

NASA historical data book. Volume 1: NASA resources 1958-1968

NASA Technical Reports Server (NTRS)

Vannimmen, Jane; Bruno, Leonard C.; Rosholt, Robert L.

1988-01-01

This is Volume 1, NASA Resources 1958-1968, of a multi-volume series providing a 20-year compilation of summary statistical and other data descriptive of NASA's programs in aeronautics and manned and unmanned spaceflight. This series is an important component of NASA published historical reference works, used by NASA personnel, managers, external researchers, and other government agencies.

Emblem - NASA Skylab (SL) Program

NASA Image and Video Library

1973-04-25

S73-23952 (May 1973) --- This is the official emblem for the National Aeronautics and Space Administration's (NASA) Skylab Program. The emblem depicts the United States Skylab space station cluster in Earth orbit with the sun in the background. Skylab will evaluate systems and techniques designed to gather information on Earth resources and environmental problems. Solar telescopes will increase man's knowledge of our sun and the multitude of solar influences on Earth environment. Medical experiments will increase knowledge of man himself and his relationship to his earthly environment and adaptability to spaceflight. Additionally, Skylab will experiment with industrial processes which may be enhanced by the unique weightless, vacuum environment of orbital spaceflight. The 100-ton laboratory complex Skylab space station is composed of the Command/Service Module (CSM), Orbital Workshop (OW), Apollo Telescope Mount (ATM), Multiple Docking Adapter (MDA), and Airlock Module (AM). The NASA insignia design for Skylab is reserved for use by the astronauts and for other official use as the NASA Administrator may authorize. Public availability has been approved only in the form of illustrations by the various news media. When and if there is any change in this policy, which we do not anticipate, it will be publicly announced. Photo credit: NASA

Limitations to the study of man in space in the U.S. space program

NASA Technical Reports Server (NTRS)

Bishop, Phillip A.; Greenisen, Mike

1993-01-01

Research on humans conducted during spaceflight is fraught both with great opportunities and great obstacles. The purpose of this paper is to review some of the limitations to research in space in the United States with hope that an informed scientific community may lead to more rapid and efficient solution of these problems. Limitations arise because opportunities to study the same astronauts in well-controlled situations on repeated spaceflights are practically non-existent. Human research opportunities are further limited by the necessity of avoiding simultaneous mutually-interfering experiments. Environmental factors, including diet and other physiological perturbations concomitant with spaceflight, also complicate research design and interpretation. Technical limitations to research methods and opportunities further restrict the development of the knowledge base. Finally, Earth analogues of space travel all suffer from inadequacies. Though all of these obstacles will eventually be overcome, creativity, diligence, and persistence are required to further our knowledge of humans in space.

Limitations to the study of man in space in the U.S. space program.

PubMed

Bishop, P A; Greenisen, M

1993-03-01

Research on humans conducted during spaceflight is fraught both with great opportunities and great obstacles. The purpose of this paper is to review some of the limitations to research in space in the United States with hope that an informed scientific community may lead to more rapid and efficient solution of these problems. Limitations arise because opportunities to study the same astronauts in well-controlled situations on repeated spaceflights are practically non-existent. Human research opportunities are further limited by the necessity of avoiding simultaneous mutually-interfering experiments. Environmental factors, including diet and other physiological perturbations concomitant with spaceflight, also complicate research design and interpretation. Technical limitations to research methods and opportunities further restrict the development of the knowledge base. Finally, Earth analogues of space travel all suffer from inadequacies. Though all of these obstacles will eventually be overcome, creativity, diligence, and persistence are required to further our knowledge of humans in space.

NASA-STD-3001, Space Flight Human-System Standard and the Human Integration Design Handbook

NASA Technical Reports Server (NTRS)

Whitmore, Mihriban; Boyer, Jennifer; Holubec, Keith

2012-01-01

NASA-STD-3001 Space Flight Human-System Standard Volume 1, Crew Health, Volume 2, Human Factors, Habitability and Environmental Health, and the Human Integration Design Handbook (HIDH) have replaced the Man-Systems Integration Standards (MSIS), NASA-STD-3000. For decades, NASA-STD-3000 was a significant contribution to human spaceflight programs and to human-systems integration. However, with research program and project results being realized, advances in technology, and the availability of new information in a variety of topic areas, the time had arrived to update this extensive suite of standards and design information. NASA-STD-3001, Volume 2 contains the Agency level standards from the human and environmental factors disciplines that ensure human spaceflight operations are performed safely, efficiently, and effectively. The HIDH is organized in the same sequence and serves as the companion document to NASA-STD-3001, Volume 2, providing a compendium of human spaceflight history and knowledge. The HIDH is intended to aid interpretation of NASA-STD-3001, Volume 2 standards and to provide guidance for requirement writers and vehicle and habitat designers. Keywords Human Factors, Standards, Environmental Factors, NASA

History of the Animal Care Program at Johnson Space Center

NASA Technical Reports Server (NTRS)

Khan-Mayberry, Noreen; Bassett, Stephanie

2010-01-01

NASA has a rich history of scientific research that has been conducted throughout our numerous manned spaceflight programs. This scientific research has included animal test subjects participating in various spaceflight missions, including most recently, Space Shuttle mission STS-131. The Animal Care Program at Johnson Space Center (JSC) in Houston, Texas is multi-faceted and unique in scope compared to other centers within the agency. The animal care program at JSC has evolved from strictly research to include a Longhorn facility and the Houston Zoo's Attwater Prairie Chicken refuge, which is used to help repopulate this endangered species. JSC is home to more than 300 species of animals including home of hundreds of white-tailed deer that roam freely throughout the center which pose unique issues in regards to population control and safety of NASA workers, visitors and tourists. We will give a broad overview of our day to day operations, animal research, community outreach and protection of animals at NASA Johnson Space Center.

Historical aspects of the early Soviet/Russian manned space program.

PubMed

West, J B

2001-10-01

Human spaceflight was one of the great physiological and engineering triumphs of the 20th century. Although the history of the United States manned space program is well known, the Soviet program was shrouded in secrecy until recently. Konstantin Edvardovich Tsiolkovsky (1857-1935) was an extraordinary Russian visionary who made remarkable predictions about space travel in the late 19th century. Sergei Pavlovich Korolev (1907-1966) was the brilliant "Chief Designer" who was responsible for many of the Soviet firsts, including the first artificial satellite and the first human being in space. The dramatic flight of Sputnik 1 was followed within a month by the launch of the dog Laika, the first living creature in space. Remarkably, the engineering work for this payload was all done in less than 4 wk. Korolev's greatest triumph was the flight of Yuri Alekseyevich Gagarin (1934-1968) on April 12, 1961. Another extraordinary feat was the first extravehicular activity by Aleksei Arkhipovich Leonov (1934-) using a flexible airlock that emphasized the entrepreneurial attitude of the Soviet engineers. By the mid-1960s, the Soviet program was overtaken by the United States program and attempts to launch a manned mission to the Moon failed. However, the early Soviet manned space program has a preeminent place in the history of space physiology.

ASTRONAUT CONRAD, CHARLES (PETE), JR. - X-RAYS - MEDICAL TEAM MEMBERS - CAPE

NASA Image and Video Library

1965-08-17

S65-28699 (17 Aug. 1965) --- Astronaut Charles Conrad Jr. (dark shirt), pilot for the Gemini-5 spaceflight, discusses x-rays with members of the medical team at Cape Kennedy. Left to right are Dr. Eugene Tubbs; astronaut Conrad; Dr. Charles A. Berry, chief, Center Medical Programs, Manned Spacecraft Center; and Dr. Robert Moser (seated), Medical Monitor with the U.S. Army.

Apollo experience report: Simulation of manned space flight for crew training

NASA Technical Reports Server (NTRS)

Woodling, C. H.; Faber, S.; Vanbockel, J. J.; Olasky, C. C.; Williams, W. K.; Mire, J. L. C.; Homer, J. R.

1973-01-01

Through space-flight experience and the development of simulators to meet the associated training requirements, several factors have been established as fundamental for providing adequate flight simulators for crew training. The development of flight simulators from Project Mercury through the Apollo 15 mission is described. The functional uses, characteristics, and development problems of the various simulators are discussed for the benefit of future programs.

Research on sleep, circadian rhythms and aging - Applications to manned spaceflight

NASA Technical Reports Server (NTRS)

Czeisler, Charles A.; Chiasera, August J.; Duffy, Jeanne F.

1991-01-01

Disorders of sleep and circadian rhythmicity are characteristic of both advancing age and manned spaceflight. Sleep fragmentation, reduced nocturnal sleep tendency and sleep efficiency, reduced daytime alertness, and increased daytime napping are common to both of these conditions. Recent research on the pathophysiology and treatment of disrupted sleep in older people has led to a better understanding of how the human circadian pacemaker regulates the timing of the daily sleep-wake cycle and how it responds to the periodic changes in the light-dark cycle to which we are ordinarily exposed. These findings have led to new treatments for some of the sleep disorders common to older individuals, using carefully timed exposure to bright light and darkness to manipulate the phase and/or amplitude of the circadian timing system. These insights and treatment approaches have direct applications in the design of countermeasures allowing astronauts to overcome some of the challenges which manned spaceflight poses for the human circadian timing system. We have conducted an operational feasibility study on the use of scheduled exposure to bright light and darkness prior to launch in order to facilitate adaptation of the circadian system of a NASA Space Shuttle crew to the altered sleep-wake schedule required for their mission. The results of this study illustrate how an understanding of the properties of the human circadian timing system and the consequences of circadian disruption can be applied to manned spaceflight.

Research on sleep, circadian rhythms and aging: applications to manned spaceflight.

PubMed

Czeisler, C A; Chiasera, A J; Duffy, J F

1991-01-01

Disorders of sleep and circadian rhythmicity are characteristic of both advancing age and manned spaceflight. Sleep fragmentation, reduced nocturnal sleep tendency and sleep efficiency, reduced daytime alertness, and increased daytime napping are common to both of these conditions. Recent research on the pathophysiology and treatment of disrupted sleep in older people has led to a better understanding of how the human circadian pacemaker regulates the timing of the daily sleep-wake cycle and how it responds to the periodic changes in the light-dark cycle to which we are ordinarily exposed. These findings have led to new treatments for some of the sleep disorders common to older individuals, using carefully timed exposure to bright light and darkness to manipulate the phase and/or amplitude of the circadian timing system. These insights and treatment approaches have direct applications in the design of countermeasures allowing astronauts to overcome some of the challenges which manned spaceflight poses for the human circadian timing system. We have conducted an operational feasibility study on the use of scheduled exposure to bright light and darkness prior to launch in order to facilitate adaptation of the circadian system of a NASA space shuttle crew to the altered sleep-wake schedule required for their mission. The results of this study illustrate how an understanding of the properties of the human circadian timing system and the consequences of circadian disruption can be applied to manned spaceflight.

[Psychological issues in manned spaceflight].

PubMed

Zhang, Q J; Bai, Y Q

1999-04-01

As the duration of manned spaceflight becomes longer and as crews become more heterogeneous, psychological and interpersonal factors will be more important in affecting the safety of crew and flight mission. In space environment there are four types of stressors: physical, physiological, psychological and interpersonal. Psychological issues include "Asthenia", alteration in time sense, transcendent experiences, sleep problem, career motivation, psychosomatic symptoms and psychiatric issues. Interpersonal issues include interpersonal tension, interpersonal relationships decreased cohesiveness and deprivation, displacement [correction of dispiacement] of anger to outside personnel over time.

Hydrocortisone and ACTH levels in manned spaceflight

NASA Technical Reports Server (NTRS)

Leach, C. S.; Campbell, B. O.

1974-01-01

The plasma hydrocortisone, plasma ACTH, and urinary hydrocortisone values were recorded for each man of the crews of Apollo flights eight through fifteen, 30, 14, and 5 days before flight, immediately after spaceflight recovery, and on future days until the return of most variables to preflight values. The plasma and urinary preflight hydrocortisone values were significantly higher than the postflight values. This result is discussed in terms of three possible explanations: (1) the adrenal-cortical function is suppressed during spaceflight; (2) the activity in flight may amount to stressful exercise, which tests have shown can cause a decrease in plasma adrenocortical hormones; and (3) the in-flight work-rest cycles may be such as to affect the circadian periodicity of the pituitary-adrenal function.

Control mechanisms of circadian rhythms in body composition: Implications for manned spaceflight

NASA Technical Reports Server (NTRS)

Moore-Ede, M. C.

1976-01-01

The mechanisms underlying the internal synchronization of the circadian variations in electrolyte content in body compartments were investigated, and the significance of these oscillations for manned spaceflight were examined. The experiments were performed with a chair-acclimatized squirrel monkey system, in which the animal sits in a chair, restrained only around the waist. The following information was given: (1) experimental methodology description, (2) summary of results obtained during the first contract year, and (3) discussion of the research performed during the second contract year. This included the following topics: physiological mechanisms promoting normal circadian internal synchronization, factors precipitating internal desynchronization, pathophysiological consequences of internal desynchronization of particular relevance to spaceflight, and validation of a chair-acclimatized system.

Countermeasures for Maintenance of Cardiovascular and Muscle Function in Space Flight

NASA Technical Reports Server (NTRS)

1997-01-01

In this session, Session FA2, the discussion focuses on the following topics: Effects of Repeated Long Duration +2Gz Load on Man's Cardiovascular Function; Certain Approaches to the Development of On-Board Automated Training System; Cardiac, Arterial, and Venous Adaptation to Og during 6 Month MIR-Spaceflights with and without "Thigh Cuffs" (93-95); Space Cycle(TM) Induced Physiologic Responses; Muscular Deconditioning During Long-term Spaceflight Exercise Recommendations to Optimize Crew Performance; Structure And Function of Knee Extensors After Long-Duration Spaceflight in Man, Effects of Countermeasure Exercise Training; Force and power characteristics of an exercise ergometer designed for use in space; and The simulating of overgravity conditions for astronauts' motor apparatus at the conditions of the training for orbital flights.

Crew Systems Laboratory/Building 7. Historical Documentation

NASA Technical Reports Server (NTRS)

Slovinac, Patricia

2011-01-01

Building 7 is managed by the Crew and Thermal Systems Division of the JSC Engineering Directorate. Originally named the Life Systems Laboratory, it contained five major test facilities: two advanced environmental control laboratories and three human-rated vacuum chambers (8 , 11 , and the 20 ). These facilities supported flight crew familiarization and the testing and evaluation of hardware used in the early manned spaceflight programs, including Gemini, Apollo, and the ASTP.

Monitoring tropical environments with Space Shuttle photography

NASA Technical Reports Server (NTRS)

Helfert, Michael R.; Lulla, Kamlesh P.

1989-01-01

Orbital photography from the Space Shuttle missions (1981-88) and earlier manned spaceflight programs (1962-1975) allows remote sensing time series to be constructed for observations of environmental change in selected portions of the global tropics. Particular topics and regions include deforestation, soil erosion, supersedimentation in streams, lacustrine, and estuarine environments, and desertification in the greater Amazon, tropical Africa and Madagascar, South and Southeast Asia, and the Indo-Pacific archipelagoes.

Psychological and interpersonal issues in space.

PubMed

Kanas, N

1987-06-01

As future manned space missions become longer, and as crews become more heterogeneous, psychological and interpersonal factors will take on increasing importance in assuring mission success. On the basis of a review of more than 60 American and Soviet space simulation studies on Earth, along with reports from U.S. and Soviet space missions, the author identifies nine psychological and seven interpersonal issues, which are discussed along with pertinent research findings and examples from manned spaceflights. He concludes that more psychological and interpersonal research should be done under actual spaceflight conditions and offers suggestions.

Mercury MESSENGER Stamp Unveiling

NASA Image and Video Library

2011-05-03

From left, NASA Deputy Director, Planetary Science Division, Science Mission Directorate, Jim Adams, NASA Kennedy Space Center Director of Education and External Relations Cheryl Hurst, United States Postal Service Vice President of Finance Steve Masse, NASA Mercury Astronaut Scott Carpenter, NASA Administrator Charles Boldin, Daughters of NASA astronaut Alan Shepard, Alice Wackermann, Laura Shepard Churchley, and Julie Jenkins, and NASA Kennedy Space Center Director Robert Cabana pose for a photograph during an unveiling ceremony of two USPS stamps that commemorate and celebrate 50 years of US Spaceflight and the MESSENGER program during an event, Wednesday, May 4, 2011 at the NASA Kennedy Space Center in Cape Canaveral, Fla. One stamp commemorates NASA’s Project Mercury, America’s first manned spaceflight program, and NASA astronaut Alan Shepard’s historic flight on May 5, 1961, aboard spacecraft Freedom 7. The other stamp draws attention to NASA’s unmanned MESSENGER mission, a scientific investigation of the planet Mercury. On March 17, 2011, MESSENGER became the first spacecraft to enter into orbit around Mercury. Photo Credit: (NASA/Bill Ingalls)

STS-28 Mission Insignia

NASA Technical Reports Server (NTRS)

1988-01-01

The STS-28 insignia was designed by the astronaut crew, who said it portrays the pride the American people have in their manned spaceflight program. It depicts America (the eagle) guiding the space program (the Space Shuttle) safely home from an orbital mission. The view looks south on Baja California and the west coast of the United States as the space travelers re-enter the atmosphere. The hypersonic contrails created by the eagle and Shuttle represent the American flag. The crew called the simple boldness of the design symbolic of America's unfaltering commitment to leadership in the exploration and development of space.

Space Shuttle Projects

NASA Image and Video Library

1988-11-07

The STS-28 insignia was designed by the astronaut crew, who said it portrays the pride the American people have in their manned spaceflight program. It depicts America (the eagle) guiding the space program (the Space Shuttle) safely home from an orbital mission. The view looks south on Baja California and the west coast of the United States as the space travelers re-enter the atmosphere. The hypersonic contrails created by the eagle and Shuttle represent the American flag. The crew called the simple boldness of the design symbolic of America's unfaltering commitment to leadership in the exploration and development of space.

US experiments flown on the Soviet satellite COSMOS 936

NASA Technical Reports Server (NTRS)

Rosenzweig, S. N.; Souza, K. A.

1978-01-01

Results of spaceborne experiments onboard the Cosmos 936 satellite are reported. Alterations in normal bone chemistry, muscle structure, and general physiology resulting from spaceflight are covered along with measurements of cosmic radiation and its potential hazard to man during prolonged spaceflights. Postflight activities involving the seven U.S. experiments are emphasized.

Tolerance of centrifuge-simulated suborbital spaceflight in subjects with implanted insulin pumps.

PubMed

Levin, Dana R; Blue, Rebecca S; Castleberry, Tarah L; Vanderploeg, James M

2015-04-01

With commercial spaceflight comes the possibility of spaceflight participants (SFPs) with significant medical conditions. Those with previously untested medical conditions, such as diabetes mellitus (DM) and the use of indwelling medical devices, represent a unique challenge. It is unclear how SFPs with such devices will react to the stresses of spaceflight. This case report describes two subjects with Type I DM using insulin pumps who underwent simulated dynamic phases of spaceflight via centrifuge G force exposure. Two Type I diabetic subjects with indwelling Humalog insulin pumps, a 23-yr-old man averaging 50 u of Humalog daily and a 27-yr-old man averaging 60 u of Humalog daily, underwent seven centrifuge runs over 48 h. Day 1 consisted of two +Gz runs (peak = +3.5 Gz, run 2) and two +Gx runs (peak = +6.0 Gx, run 4). Day 2 consisted of three runs approximating suborbital spaceflight profiles (combined +Gx and +Gz). Data collected included blood pressure, electrocardiogram, pulse oximetry, neurovestibular evaluation, and questionnaires regarding motion sickness, disorientation, greyout, and other symptoms. Neither subject experienced adverse clinical responses to the centrifuge exposure. Both maintained blood glucose levels between 110-206 mg · dl(-1). Potential risks to SFPs with insulin pump dependent DM include hypo/hyperglycemia, pump damage, neurovestibular dysfunction, skin breakdown, and abnormal stress responses. A search of prior literature did not reveal any previous studies of individuals with DM on insulin pumps exposed to prolonged accelerations. These cases suggest that individuals with conditions dependent on continuous medication delivery might tolerate the accelerations anticipated for commercial spaceflight.

Humans vs Hardware: The Unique World of NASA Human System Risk Assessment

NASA Technical Reports Server (NTRS)

Anton, W.; Havenhill, M.; Overton, Eric

2016-01-01

Understanding spaceflight risks to crew health and performance is a crucial aspect of preparing for exploration missions in the future. The research activities of the Human Research Program (HRP) provide substantial evidence to support most risk reduction work. The Human System Risk Board (HSRB), acting on behalf of the Office of Chief Health and Medical Officer (OCHMO), assesses these risks and assigns likelihood and consequence ratings to track progress. Unfortunately, many traditional approaches in risk assessment such as those used in the engineering aspects of spaceflight are difficult to apply to human system risks. This presentation discusses the unique aspects of risk assessment from the human system risk perspective and how these limitations are accommodated and addressed in order to ensure that reasonable inputs are provided to support the OCHMO's overall risk posture for manned exploration missions.

History of suborbital spaceflight: medical and performance issues.

PubMed

Campbell, Mark R; Garbino, Alejandro

2011-04-01

The development of manned sub-orbital commercial space vehicles is rapidly occurring and flight testing followed by operational flights will soon begin. The experience of manned suborbital spaceflight at the designated altitude (100 km/62.14 mi) is very limited--two Mercury-Redstone flights, two X-15 flights, one inadvertent Soyuz launch abort, and three recent SpaceShipOne flights, with only 15 min of critical flight time each. All indications were that the sequence of acceleration-weightlessness-deceleration was well tolerated with minimal neurovestibular dysfunction. However, there are some indications that distraction and spatial disorientation did occur. Vertigo on transition from the boost phase to weightlessness was reported on most high-altitude X-15 flights. +Gz tolerance to re-entry deceleration forces (as high as 6 + Gz) after 4 min of weightlessness is still unknown. Only further suborbital spaceflight experience will clarify if pilot performance will be affected.

A Brief History of Meteoroid and Orbital Debris Shielding Technology for US Manned Spacecraft

NASA Technical Reports Server (NTRS)

Bjorkman, Michael D.; Hyde, James L.

2008-01-01

Meteoroid and orbital debris shielding has played an important role from the beginning of manned spaceflight. During the early 60 s, meteoroid protection drove requirements for new meteor and micrometeoroid impact science. Meteoroid protection also stimulated advances in the technology of hypervelocity impact launchers and impact damage assessment methodologies. The first phase of meteoroid shielding assessments closed in the early 70 s with the end of the Apollo program. The second phase of meteoroid protection technology began in the early 80 s when it was determined that there is a manmade Earth orbital debris belt that poses a significant risk to LEO manned spacecraft. The severity of the Earth orbital debris environment has dictated changes in Space Shuttle and ISS operations as well as driven advances in shielding technology and assessment methodologies. A timeline of shielding technology and assessment methodology advances is presented along with a summary of risk assessment results.

The Ultimate Destination: Choice of Interplanetary Exploration Path can define Future of Interstellar Spaceflight

NASA Astrophysics Data System (ADS)

Silin, D. V.

Manned interstellar spaceflight is facing multiple challenges of great magnitude; among them are extremely large distances and the lack of known habitable planets other than Earth. Many of these challenges are applicable to manned space exploration within the Solar System to the same or lesser degree. If these issues are resolved on an interplanetary scale, better position to pursue interstellar exploration can be reached. However, very little progress (if any) was achieved in manned space exploration since the end of Space Race. There is no lack of proposed missions, but all of them require considerable technological and financial efforts to implement while yielding no tangible benefits that would justify their costs. To overcome this obstacle highest priority in future space exploration plans should be assigned to the creation of added value in outer space. This goal can be reached if reductions in space transportation, construction and maintenance of space-based structures costs are achieved. In order to achieve these requirements several key technologies have to be mastered, such as near-Earth object mining, space- based manufacturing, agriculture and structure assembly. To keep cost and difficulty under control next exploration steps can be limited to nearby destinations such as geostationary orbit, low lunar orbit, Moon surface and Sun-Earth L1 vicinity. Completion of such a program will create a solid foundation for further exploration and colonization of the Solar System, solve common challenges of interplanetary and interstellar spaceflight and create useful results for the majority of human population. Another important result is that perception of suitable destinations for interstellar missions will change significantly. If it becomes possible to create habitable and self-sufficient artificial environments in the nearby interplanetary space, Earth-like habitable planets will be no longer required to expand beyond our Solar System. Large fraction of the stars in the observable Universe will become valid targets for interstellar missions.

Skeletal responses to spaceflight

NASA Technical Reports Server (NTRS)

Morey-Holton, Emily R.; Arnaud, Sara B.

1991-01-01

The effect of gravity on the skeletal development and on the bone composition and its regulation in vertebrates is discussed. Results are presented from spaceflight and ground studies in both man and rat on the effect of microgravity on the bone-mineral metabolism (in both species) and on bone maturation and growth (in rats). Special attention is given to a ground-based flight-simulation rat model developed at NASA's Ames Research Center for studies of bone structure at the molecular, organ, and whole-body levels and to comparisons of estimated results with spaceflight data.

Spaceflight Decompression Sickness Contingency Plan

NASA Technical Reports Server (NTRS)

Dervay, Joseph P.

2007-01-01

A viewgraph presentation on the Decompression Sickness (DCS) Contingency Plan for manned spaceflight is shown. The topics include: 1) Approach; 2) DCS Contingency Plan Overview; 3) Extravehicular Activity (EVA) Cuff Classifications; 4) On-orbit Treatment Philosophy; 5) Long Form Malfunction Procedure (MAL); 6) Medical Checklist; 7) Flight Rules; 8) Crew Training; 9) Flight Surgeon / Biomedical Engineer (BME) Training; and 10) DCS Emergency Landing Site.

We can't explore space without it - Common human space needs for exploration spaceflight

NASA Technical Reports Server (NTRS)

Daues, K. R.; Erwin, H. O.

1992-01-01

An overview is conducted of physiological, psychological, and human-interface requirements for manned spaceflight programs to establish common criteria. Attention is given to the comfort levels relevant to human support in exploration mission spacecraft and planetary habitats, and three comfort levels (CLs) are established. The levels include: (1) CL-1 for basic crew life support; (2) CL-2 for enabling the nominal completion of mission science; and (3) CL-3 which provides for enhanced life support and user-friendly interface systems. CL-2 support systems can include systems for EVA, workstations, and activity centers for repairs and enhanced utilization of payload and human/machine integration. CL-3 supports can be useful for maintaining crew psychological and physiological health as well as the design of comfortable and earthlike surroundings. While all missions require CL-1 commonality, CL-2 commonality is required only for EVA systems, display nomenclature, and restraint designs.

Time-Dependent Material Data Essential for the Durability Analysis of Composite Flywheels Provided by Compressive Experiments

NASA Technical Reports Server (NTRS)

Thesken, John C.; Bowman, Cheryl L.; Arnold, Steven M.

2003-01-01

Successful spaceflight operations require onboard power management systems that reliably achieve mission objectives for a minimal launch weight. Because of their high specific energies and potential for reduced maintenance and logistics, composite flywheels are an attractive alternative to electrochemical batteries. The Rotor Durability Team, which comprises members from the Ohio Aerospace Institute (OAI) and the NASA Glenn Research Center, completed a program of elevated temperature testing at Glenn' s Life Prediction Branch's Fatigue Laboratory. The experiments provided unique design data essential to the safety and durability of flywheel energy storage systems for the International Space Station and other manned spaceflight applications. Analysis of the experimental data (ref. 1) demonstrated that the compressive stress relaxation of composite flywheel rotor material is significantly greater than the commonly available tensile stress relaxation data. Durability analysis of compression preloaded flywheel rotors is required for accurate safe-life predictions for use in the International Space Station.

Aeronautics and space report of the President, 1982 activities

NASA Technical Reports Server (NTRS)

1983-01-01

Achievements of the space program are summerized in the area of communication, Earth resources, environment, space sciences, transportation, aeronautics, and space energy. Space program activities of the various deprtments and agencies of the Federal Government are discussed in relation to the agencies' goals and policies. Records of U.S. and world spacecraft launchings, successful U.S. launches for 1982, U.S. launched applications and scientific satellites and space probes since 1975, U.S. and Soviet manned spaceflights since 1961, data on U.S. space launch vehicles, and budget summaries are provided. The national space policy and the aeronautical research and technology policy statements are included.

Manned space flight in debate - An interdisciplinary project for technical decision making will make the discussion more rational

NASA Astrophysics Data System (ADS)

Gethmann, Carl F.; Janich, Peter; Sax, Hartmut

1992-08-01

Arguments for manned spaceflight that do not depend on cost-benefit analysis are examined. Project Safire is used to illustrate arguments based on the need to further international cooperation, promote national morale, and motivate technological investigations.

Tracking reliability for space cabin-borne equipment in development by Crow model.

PubMed

Chen, J D; Jiao, S J; Sun, H L

2001-12-01

Objective. To study and track the reliability growth of manned spaceflight cabin-borne equipment in the course of its development. Method. A new technique of reliability growth estimation and prediction, which is composed of the Crow model and test data conversion (TDC) method was used. Result. The estimation and prediction value of the reliability growth conformed to its expectations. Conclusion. The method could dynamically estimate and predict the reliability of the equipment by making full use of various test information in the course of its development. It offered not only a possibility of tracking the equipment reliability growth, but also the reference for quality control in manned spaceflight cabin-borne equipment design and development process.

Human Factors, Habitability and Environmental Health and the Human Integration Design Handbook. Volume 2

NASA Technical Reports Server (NTRS)

Houbec, Keith; Tillman, Barry; Connolly, Janis

2010-01-01

For decades, Space Life Sciences and NASA as an Agency have considered NASA-STD-3000, Man-Systems Integration Standards, a significant contribution to human spaceflight programs and to human-systems integration in general. The document has been referenced in numerous design standards both within NASA and by organizations throughout the world. With research program and project results being realized, advances in technology and new information in a variety of topic areas now available, the time arrived to update this extensive suite of requirements and design information. During the past several years, a multi-NASA center effort has been underway to write the update to NASA-STD-3000 with standards and design guidance that would be applicable to all future human spaceflight programs. NASA-STD-3001 - Volumes 1 and 2 - and the Human Integration Design Handbook (HIDH) were created. Volume 1, Crew Health, establishes NASA s spaceflight crew health standards for the pre-flight, in-flight, and post-flight phases of human spaceflight. Volume 2, Human Factors, Habitability and Environmental Health, focuses on the requirements of human-system integration and how the human crew interacts with other systems, and how the human and the system function together to accomplish the tasks for mission success. The HIDH is a compendium of human spaceflight history and knowledge, and provides useful background information and research findings. And as the HIDH is a stand-alone companion to the Standards, the maintenance of the document has been streamlined. This unique and flexible approach ensures that the content is current and addresses the fundamental advances of human performance and human capabilities and constraints research. Current work focuses on the development of new sections of Volume 2 and collecting updates to the HIDH. The new sections in development expand the scope of the standard and address mission operations and support operations. This effort is again collaboration with representatives from the Johnson Space Center Missions Operations and Space Life Sciences Directorates and the Engineering Directorate from Kennedy Space Center as well as discipline experts from across the Agency.

A health care system for the Space Station

NASA Technical Reports Server (NTRS)

1992-01-01

Life science will be one of the pacing technologies for long duration manned spaceflight. The ability to effectively deliver state-of-the-art inflight medical care will have a major impact on crew health and mission success. The future Space Station crews will participate in missions of extended duration with limited capability for emergency return. This factor alone places great responsibility on program designers to ensure the health, safety, and well-being of the crews. The Health Maintenance Facility (HMF) under development at the Johnson Space Center is described.

Space vestibulo-neuroscience in the new century

NASA Technical Reports Server (NTRS)

Money, K. E.; Young, L. R. (Principal Investigator)

1993-01-01

In the new century there will probably be more long spaceflights and fewer short spaceflights. There will probably be several flights to Mars, flights that (if chemical rockets are used) will involve one year to get there, a second year on Mars, and a third year to return. The three-year Mars scenario will probably include rotation of the spacecraft to provide artificial gravity. If nuclear thermal rockets are used, a manned exploration of Mars could be accomplished in less than one year. Vestibular research will be directed towards ensuring that astronauts, upon landing on Mars, will be able to walk with confidence and without delay. Research will be required to investigate vestibular adaptation in spaceflight, motion sickness, and the vestibular effects of rotation in spaceflight.

Design and Verification of Critical Pressurised Windows for Manned Spaceflight

NASA Astrophysics Data System (ADS)

Lamoure, Richard; Busto, Lara; Novo, Francisco; Sinnema, Gerben; Leal, Mendes M.

2014-06-01

The Window Design for Manned Spaceflight (WDMS) project was tasked with establishing the state-of-art and explore possible improvements to the current structural integrity verification and fracture control methodologies for manned spacecraft windows.A critical review of the state-of-art in spacecraft window design, materials and verification practice was conducted. Shortcomings of the methodology in terms of analysis, inspection and testing were identified. Schemes for improving verification practices and reducing conservatism whilst maintaining the required safety levels were then proposed.An experimental materials characterisation programme was defined and carried out with the support of the 'Glass and Façade Technology Research Group', at the University of Cambridge. Results of the sample testing campaign were analysed, post-processed and subsequently applied to the design of a breadboard window demonstrator.Two Fused Silica glass window panes were procured and subjected to dedicated analyses, inspection and testing comprising both qualification and acceptance programmes specifically tailored to the objectives of the activity.Finally, main outcomes have been compiled into a Structural Verification Guide for Pressurised Windows in manned spacecraft, incorporating best practices and lessons learned throughout this project.

Overview of medical operations for a manned stratospheric balloon flight.

PubMed

Blue, Rebecca S; Law, Jennifer; Norton, Sean C; Garbino, Alejandro; Pattarini, James M; Turney, Matthew W; Clark, Jonathan B

2013-03-01

Red Bull Stratos was a commercial program designed to bring a test parachutist protected by a full-pressure suit via a stratospheric balloon with a pressurized capsule to 120,000 ft (36,576 m), from which he would freefall and subsequently parachute to the ground. On March 15, 2012, the Red Bull Stratos program successfully conducted a preliminary manned balloon test flight and parachute jump, reaching a final altitude of 71,581 ft (21,818 m). In light of the uniqueness of the operation and medical threats faced, a comprehensive medical plan was needed to ensure prompt and efficient response to any medical contingencies. This report will serve to discuss the medical plans put into place before the first manned balloon flight and the actions of the medical team during that flight. The medical operations developed for this program will be systematically evaluated, particularly, specific recommendations for improvement in future high-altitude and commercial space activities. A multipronged approach to medical support was developed, consisting of event planning, medical personnel, equipment, contingency-specific considerations, and communications. Medical operations were found to be highly successful when field-tested during this stratospheric flight, and the experience allowed for refinement of medical operations for future flights. The lessons learned and practices established for this program can easily be used to tailor a plan specific to other aviation or spaceflight events.

Twenty-Five Years of Progress. Part 1: Birth of NASA. Part 2: The Moon-A Goal

NASA Technical Reports Server (NTRS)

1984-01-01

Historical footage (1958 - 1983) concerning NASA's Space Program, is reviewed in this two-part video. Host, Lynn Bondurant describes the birth of NASA and its accomplishments through the years. Part one contains: the launch of Russian satellite Sputnik on October 4,1957; the first dog (Soviet) in space; NACA Space Research, Explorer-6; and still photographs of various Space projects. Tiros 1 experimental weather satellite, Microgravity simulators, Echo 1 passive communications satellite, and the first U.S. manned spaceflight Mercury are included in part two. The seven Mercury astronauts are: Captain Donald Slayton, Lt. Commander Alan Shepard, Lt. Commander Walter Schirra, Captain Virgil Grissom, Lt. Col. John Glenn Jr., Captain Leroy Cooper Jr, and Lt. Malcolm Scott Carpenter. Also included are an ongoing interview (throughout the video) with NASA's first Administrator Keith Glennan, the first flight in 1961 with Enos, a chimpanzee, President Kennedy's speech in Washington about the Space Program, Project Gemini - the 2-manned space flights, and the recovery of Virgil Grissom from splash down.

On humanity's role in space

NASA Technical Reports Server (NTRS)

Von Puttkamer, J.

1978-01-01

Manned spaceflight is considered within the framework of two broad categories: human exploitation of space for economic or scientific gain, and human habitation of space as a place where man may live, grow, and actualize himself. With the advent of the Space Shuttle, exploitation of space will take the form of new product development. This will continue during the 1990s as the new products are manufactured on a scale large enough to be profitable. The turn of the century should see major industries in space, and large space habitats. Thus, the question of mankind's existential needs arises. In addition to basic physical needs, the spiritual and cultural requirements of human beings must be considered. The impact of man's presence in space upon human culture in general is discussed with reference to international cooperation, public interest in space programs, scientific advancement, the basic urge to explore, and the density of mankind as a whole; which will become free of external constraints as we step into the cosmos.

Calysto: Risk Management for Commercial Manned Spaceflight

NASA Technical Reports Server (NTRS)

Dillaman, Gary

2012-01-01

The Calysto: Risk Management for Commercial Manned Spaceflight study analyzes risk management in large enterprises and how to effectively communicate risks across organizations. The Calysto Risk Management tool developed by NASA's Kennedy Space Center's SharePoint team is used and referenced throughout the study. Calysto is a web-base tool built on Microsoft's SharePoint platform. The risk management process at NASA is examined and incorporated in the study. Using risk management standards from industry and specific organizations at the Kennedy Space Center, three methods of communicating and elevating risk are examined. Each method describes details of the effectiveness and plausibility of using the method in the Calysto Risk Management Tool. At the end of the study suggestions are made for future renditions of Calysto.

Human factors - Man-machine symbiosis in space

NASA Technical Reports Server (NTRS)

Brown, Jeri W.

1987-01-01

The relation between man and machine in space is studied. Early spaceflight and the goal of establishing a permanent space presence are described. The need to consider the physiological, psychological, and social integration of humans for each space mission is examined. Human factors must also be considered in the design of spacecraft. The effective utilization of man and machine capabilities, and research in anthropometry and biomechanics aimed at determining the limitations of spacecrews are discussed.

Aerospace bibliography, seventh edition

NASA Technical Reports Server (NTRS)

Blashfield, J. F. (Compiler)

1983-01-01

Space travel, planetary probes, applications satellites, manned spaceflight, the impacts of space exploration, future space activities, astronomy, exobiology, aeronautics, energy, space and the humanities, and aerospace education are covered.

Could spaceflight-associated immune system weakening preclude the expansion of human presence beyond Earth's orbit?

PubMed

Guéguinou, Nathan; Huin-Schohn, Cécile; Bascove, Matthieu; Bueb, Jean-Luc; Tschirhart, Eric; Legrand-Frossi, Christine; Frippiat, Jean-Pol

2009-11-01

This year, we celebrate the 40th birthday of the first landing of humans on the moon. By 2020, astronauts should return to the lunar surface and establish an outpost there that will provide a technical basis for future manned missions to Mars. This paper summarizes major constraints associated with a trip to Mars, presents immunological hazards associated with this type of mission, and shows that our current understanding of the immunosuppressive effects of spaceflight is limited. Weakening of the immune system associated with spaceflight is therefore an area that should be considered more thoroughly before we undertake prolonged space voyages.

Mission Assurance and Flight Safety of Manned Space Flight: Implications for Future Exploration of the Moon and Mars

NASA Technical Reports Server (NTRS)

Kezirian, M. T.

2007-01-01

As NASA implements the nation's Vision for Space Exploration to return to the moon and travel to Mars, new considerations will be be given to the processes governing design and operations of manned spaceflight. New objectives bring new technical challenges; Safety will drive many of these decisions.

Multidisciplinary Russian biomedical research in space

NASA Astrophysics Data System (ADS)

Orlov, O. I.; Sychev, V. N.; Samarin, G. I.; Ilyin, E. A.; Belakovskiy, M. S.; Kussmaul, A. R.

2014-08-01

Research activities on a comprehensive multidisciplinary program are vital for enhancement of the system of crew's medical care, environmental health and hygiene in space missions. The primary goal of the program must be identification of patterns, intensity and dynamics of structural and functional shifts in organism induced by an aggregate of spaceflight factors including microgravity, isolation, artificial environment, space radiation, etc. Also, the program must pursue differential assessment of emerging deviations from the standpoint of adequacy to the spaceflight conditions and prospects of returning to Earth and guide the development of principles, methods and techniques necessary to maintain health and working capacity of humans during short- and long-duration missions and on return to Earth. Over 50 years, since 1963, the IBMP researchers apply systemic and innovational approaches to fundamental and exploratory studies in the fields of medical sciences, radiation biology, engineering science, biotechnology, etc. with participation of various biological specimens and human volunteers. Investigations aboard manned spacecrafts and biological satellites as well as in ground-based laboratories further enhancement of the medical care system for crews on orbital and remote space missions; they give insight into the fundamental problems of gravitational physiology and biology, psychophysiology, radiation biology, and contribute thereby to the development of knowledge, methods and technologies, as well as medical and scientific equipment.

First Apollo 11 Lunar Samples Arrive at the Manned Spacecraft Center (MSC)

NASA Technical Reports Server (NTRS)

1969-01-01

The Apollo 11 mission, the first manned lunar mission, launched from the Kennedy Space Center, Florida via the Marshall Space Flight Center (MSFC) developed Saturn V launch vehicle on July 16, 1969 and safely returned to Earth on July 24, 1969. Aboard the space craft were astronauts Neil A. Armstrong, commander; Michael Collins, Command Module (CM) pilot; and Edwin E. Aldrin Jr., Lunar Module (LM) pilot. The CM, piloted by Michael Collins remained in a parking orbit around the Moon while the LM, named 'Eagle'', carrying astronauts Neil Armstrong and Edwin Aldrin, landed on the Moon. During 2½ hours of surface exploration, the crew collected 47 pounds of lunar surface material for analysis back on Earth. This photograph was taken as the mission's first loaded sample return container arrived at Ellington Air Force Base by air from the Pacific recovery area. The rock box was immediately taken to the Lunar Receiving Laboratory at the Manned Spacecraft Center (MSC) in Houston, Texas. Happily posing for the photograph with the rock container are (L-R) Richard S. Johnston (back), special assistant to the MSC Director; George M. Low, MSC Apollo Spacecraft Program manager; George S. Trimble (back), MSC Deputy Director; Lt. General Samuel C. Phillips, Apollo Program Director, Office of Manned Spaceflight at NASA headquarters; Eugene G. Edmonds, MSC Photographic Technology Laboratory; Dr. Thomas O. Paine, NASA Administrator; and Dr. Robert R. Gilruth, MSC Director.

GEMINI-TITAN (GT)-9- TRAINING - AEROSPACE FLIGHT SIMULATOR - PILOT - TX

NASA Image and Video Library

1966-03-01

S66-27990 (March 1966) --- Astronaut Eugene A. Cernan, pilot for the Gemini-9 spaceflight, works out procedures for his historic space excursion in a unique manned Aerospace Flight Simulator at LTV Corp. at Dallas, Texas. The LTV simulator is used frequently by NASA astronauts for a variety of space programs maneuvers to provide many of the sensations and visual scenes of actual spaceflight. Controlled through a complex of computers, the device makes it possible for the astronauts to work out procedures, solve problems and simulate missions in real time with great accuracy. The astronaut rides in a spacecraft-like gondola which moves in roll, pitch and yaw in response to his controls and accurate computer inputs. The simulator's usual spacecraft displays and canopy have been removed and AMU backpack complete with control electronics installed. The astronaut makes his simulated flight in an inflated pressure suit and with the NASA-developed Extravehicular Life Support system chest pack which will be used in the Gemini flight. Photo credit: NASA

MCC History

NASA Image and Video Library

2017-02-12

Since the days of Gemini all of America’s human spaceflight programs have been controlled by men and women stationed in one of several flight control rooms at NASA’s Johnson Space Center in Houston: the International Space Station flight controllers recently moved into an upgraded facility in the room that hosted the teams during the first manned flights of Apollo and the space shuttle. Here’s a tour of “Mission Control Houston” through the years, from its first generation through the facility ready for the flights of Orion, the spacecraft that will take humans farther into space than they’ve ever gone before.

The ICV Study: Integrated Cardiovascular

NASA Technical Reports Server (NTRS)

Levine, Benjamin D.; Bungo, Michael W.

2009-01-01

This viewgraph presentation describes the effects of long duration manned spaceflight on heart structure and function. Clinical consequences for orthostatic tolerance, cardiac arrhythmias, and countermeasures to prevent clinical problems are also discussed.

View of food packets for the Gemini 7 space flight

NASA Image and Video Library

1965-12-10

S65-61653 (1 Dec. 1965) --- Complete food supply for the two-man crew of the National Aeronautics and Space Administration's Gemini-7 spaceflight as it appears prior to stowage in the spacecraft. The food packages are tied in sequence for 28-manned days or a complete supply for two men for a 14-day mission. Photo credit: NASA

Saturn Apollo Program

NASA Image and Video Library

1969-07-25

The Apollo 11 mission, the first manned lunar mission, launched from the Kennedy Space Center, Florida via the Marshall Space Flight Center (MSFC) developed Saturn V launch vehicle on July 16, 1969 and safely returned to Earth on July 24, 1969. Aboard the space craft were astronauts Neil A. Armstrong, commander; Michael Collins, Command Module (CM) pilot; and Edwin E. Aldrin Jr., Lunar Module (LM) pilot. The CM, piloted by Michael Collins remained in a parking orbit around the Moon while the LM, named “Eagle’’, carrying astronauts Neil Armstrong and Edwin Aldrin, landed on the Moon. During 2½ hours of surface exploration, the crew collected 47 pounds of lunar surface material for analysis back on Earth. This photograph was taken as the mission’s first loaded sample return container arrived at Ellington Air Force Base by air from the Pacific recovery area. The rock box was immediately taken to the Lunar Receiving Laboratory at the Manned Spacecraft Center (MSC) in Houston, Texas. Happily posing for the photograph with the rock container are (L-R) Richard S. Johnston (back), special assistant to the MSC Director; George M. Low, MSC Apollo Spacecraft Program manager; George S. Trimble (back), MSC Deputy Director; Lt. General Samuel C. Phillips, Apollo Program Director, Office of Manned Spaceflight at NASA headquarters; Eugene G. Edmonds, MSC Photographic Technology Laboratory; Dr. Thomas O. Paine, NASA Administrator; and Dr. Robert R. Gilruth, MSC Director.

The future of human spaceflight.

PubMed

Reichert, M

2001-01-01

After the Apollo Moon program, the international space station represents a further milestone of humankind in space, International follow-on programs like a manned return to the Moon and a first manned Mars Mission can be considered as the next logical step. More and more attention is also paid to the topic of future space tourism in Earth orbit, which is currently under investigation in the USA, Japan and Europe due to its multibillion dollar market potential and high acceptance in society. The wide variety of experience, gained within the space station program, should be used in order to achieve time and cost savings for future manned programs. Different strategies and roadmaps are investigated for space tourism and human missions to the Moon and Mars, based on a comprehensive systems analysis approach. By using DLR's software tool FAST (Fast Assessment of Space Technologies), different scenarios will be defined, optimised and finally evaluated with respect to mission architecture, required technologies, total costs and program duration. This includes trajectory analysis, spacecraft design on subsystem level, operations and life cycle cost analysis. For space tourism, an expected evolutionary roadmap will be described which is initiated by short suborbital tourism and ends with visionary designs like the Space Hotel Berlin and the Space Hotel Europe concept. Furthermore the potential space tourism market, its economic meaning as well as the expected range of the costs of a space ticket (e.g. $50,000 for a suborbital flight) will be analysed and quantified. For human missions to the Moon and Mars, an international 20 year program for the first decades of the next millennium is proposed, which requires about $2.5 Billion per year for a manned return to the Moon program and about $2.6 Billion per year for the first 3 manned Mars missions. This is about the annual budget, which is currently spend by the USA only for the operations of its Space Shuttle fleet which generally proofs the affordability of such ambitious programs after the build-up of the International Space Station, when corresponding budget might become again available. c 2001. Elsevier Science Ltd. All rights reserved.

The future of human spaceflight

NASA Astrophysics Data System (ADS)

Reichert, M.

2001-08-01

After the Apollo Moon program, the international space station represents a further milestone of humankind in space. International follow-on programs like a manned return to the Moon and a first manned Mars Mission can be considered as the next logical step. More and more attention is also paid to the topic of future space tourism in Earth orbit, which is currently under investigation in the USA, Japan and Europe due to its multibillion dollar market potential and high acceptance in society. The wide variety of experience, gained within the space station program, should be used in order to achieve time and cost savings for future manned programs. Different strategies and roadmaps are investigated for space tourism and human missions to the Moon and Mars, based on a comprehensive systems analysis approach. By using DLR's software tool FAST ( Fast Assessment of Space Technologies), different scenarios will be defined, optimised and finally evaluated with respect to mission architecture, required technologies, total costs and program duration. This includes trajectory analysis, spacecraft design on subsystem level, operations and life cycle cost analysis. For space tourism, an expected evolutionary roadmap will be described which is initiated by short suborbital tourism and ends with visionary designs like the Space Hotel Berlin and the Space Hotel Europe concept. Furthermore the potential space tourism market, its economic meaning as well as the expected range of the costs of a space ticket (e.g. 50,000 for a suborbital flight) will be analysed and quantified. For human missions to the Moon and Mars, an international 20 year program for the first decades of the next millennium is proposed, which requires about 2.5 Billion per year for a manned return to the Moon program and about $2.6 Billion per year for the first 3 manned Mars missions. This is about the annual budget, which is currently spend by the USA only for the operations of its Space Shuttle fleet which generally proofs the affordability of such ambitious programs after the build-up of the International Space Station, when corresponding budget might become again available.

Wernher von Braun

NASA Image and Video Library

1964-10-14

This photograph, dated October 14, 1964, was taken at the Marned Spacecraft Center, now the Johnson Space Center in Houston, Texas. Dr. von Braun is shown looking over consoles in the Manned Spaceflight Control Center.

Development of task network models of human performance in microgravity

NASA Technical Reports Server (NTRS)

Diaz, Manuel F.; Adam, Susan

1992-01-01

This paper discusses the utility of task-network modeling for quantifying human performance variability in microgravity. The data are gathered for: (1) improving current methodologies for assessing human performance and workload in the operational space environment; (2) developing tools for assessing alternative system designs; and (3) developing an integrated set of methodologies for the evaluation of performance degradation during extended duration spaceflight. The evaluation entailed an analysis of the Remote Manipulator System payload-grapple task performed on many shuttle missions. Task-network modeling can be used as a tool for assessing and enhancing human performance in man-machine systems, particularly for modeling long-duration manned spaceflight. Task-network modeling can be directed toward improving system efficiency by increasing the understanding of basic capabilities of the human component in the system and the factors that influence these capabilities.

Space radiation concerns for manned exploration.

PubMed

Stanford, M; Jones, J A

1999-07-01

Spaceflight exposes astronaut crews to natural ionizing radiation. To date, exposures in manned spaceflight have been well below the career limits recommended to NASA by the National Council of Radiation Protection and Measurements (NCRP). This will not be the case for long-duration exploratory class missions. Additionally. International Space Station (ISS) crews will receive higher doses than earlier flight crews. Uncertainties in our understanding of long-term bioeffects, as well as updated analyses of the Hiroshima. Nagasaki and Chernobyl tumorigenesis data, have prompted the NCRP to recommend further reductions by 30-50% for career dose limit guidelines. Intelligent spacecraft design and material selection can provide a shielding strategy capable of maintaining crew exposures within recommended guidelines. Current studies on newer radioprotectant compounds may find combinations of agents which further diminish the risk of radiation-induced bioeffects to the crew.

Human Spaceflight and American Society: The Record So Far

NASA Technical Reports Server (NTRS)

Murray, Charles

2005-01-01

This paper presents a look at the historical Apollo Program and it's comparisons to NASA's human spaceflight program today. The author gives three examples of how audacity began with the Apollo Program and explains how human spaceflight must continue with this audacity to do new things and take on large missions.

Research on lettuce growth technology onboard Chinese Tiangong II Spacelab

NASA Astrophysics Data System (ADS)

Shen, Yunze; Guo, Shuangsheng; Zhao, Pisheng; Wang, Longji; Wang, Xiaoxia; Li, Jian; Bian, Qiang

2018-03-01

Lettuce was grown in a space vegetable cultivation facility onboard the Tiangong Ⅱ Spacelab during October 18 to November 15, 2016, in order to testify the key cultivating technology in CELSS under spaceflight microgravity condition. Potable water was used for irrigation of rooting substrate and the SRF (slowly released fertilizer) offered mineral nutrition for plant growth. Water content and electric conductivity in rooting substrate were measured based on FDR(frequency domain reflectometry) principle applied first in spaceflight. Lettuce germinated with comparative growth vigor as the ground control, showing that the plants appeared to be not stressed by the spaceflight environment. Under microgravity, lettuce grew taller and showed deeper green color than the ground control. In addition, the phototropism of the on-orbit plants was more remarkable. The nearly 30-d spaceflight test verified the seed fixation technology and water& nutrition management technology, which manifests the feasibility of FDR being used for measuring moisture content and electric conductivity in rooting zone under microgravity. Furthermore, the edibility of the space-grown vegetable was proved, providing theoretical support for astronaut to consume the space vegetable in future manned spaceflight.

Securing Safety - Spaceflight Standards for the Mass Market

NASA Astrophysics Data System (ADS)

Goh, G.

The projected total revenue of the space tourism industry is expected to exceed USD $1 billion by 2021. The vast economic potential of space tourism has fuelled ambitious plans for commercial orbital and suborbital flights, in addition to longer- duration spaceflights on board the International Space Station (ISS) and other planned orbiting habitats. International and national legal frameworks are challenged to provide regulations to ensure minimum standards of spaceflight safety for a high risk activity that aims to enter the mainstream tourism market. Thrown into the mix are various considerations of the number of spaceflight participants per flight, the economic viability of stringent safety standards, the plethora of possible flight vehicles and the compensation mechanism in case of violations of safety regulations. This paper surveys the legal challenges in the regulation of safety in commercial manned spaceflight, including issues of jurisdiction, authorization, licensing and liability. Drawing on analogous developments in other fields of law related to international carriage, a safety regulation framework with minimum international standards is proposed. This proposed framework considers both accident avoidance and emergency response in light of international legal, policy and economic perspectives.

Spaceflight revolution: NASA Langley Research Center from Sputnik to Apollo

NASA Technical Reports Server (NTRS)

Hansen, James R.

1995-01-01

As part of the transition to the broad research scope of the National Aeronautics and Space Administration (NASA) starting in the late 1950's, the Langley Research Center underwent many changes in program content, organization and management, and areas of personnel expertise. This book describes and evaluates the evolution and activities of the Langley Research Center during the seventeen-year period from 1958 to 1975. The book was based on the analysis of hundreds of written records, both published and unpublished, as well as numerous personal interviews with many of the key individuals involved in the transition of Langley. Some of the projects and research areas covered include Project Echo, magnetoplasmadynamics research, Scout Rocket Program, lunar-orbit rendezvous research, manned space laboratory development, and Apollo and the Lunar Orbiter Project.

50th Anniversary of the World's First Extraterrestrial Sample Receiving Laboratory: The Apollo Program's Lunar Receiving Laboratory

NASA Technical Reports Server (NTRS)

Calaway, M. J.; Allton, J. H.; Zeigler, R. A.; McCubbin, F. M.

2017-01-01

The Apollo program's Lunar Receiving Laboratory (LRL), building 37 at NASA's Manned Spaceflight Center (MSC), now Johnson Space Center (JSC), in Houston, TX, was the world's first astronaut and extraterrestrial sample quarantine facility (Fig. 1). It was constructed by Warrior Construction Co. and Warrior-Natkin-National at a cost of $8.1M be-tween August 10, 1966 and June 26, 1967. In 1969, the LRL received and curated the first collection of extra-terrestrial samples returned to Earth; the rock and soil samples of the Apollo 11 mission. This year, the JSC Astromaterials Acquisition and Curation Office (here-after JSC curation) celebrates 50 years since the opening of the LRL and its legacy of laying the foundation for modern curation of extraterrestrial samples.

EcAMSat and BioSentinel: Autonomous Bio Nanosatellites Addressing Strategic Knowledge Gaps for Manned Spaceflight Beyond LEO

NASA Technical Reports Server (NTRS)

Padgen, Michael R.

2017-01-01

Manned missions beyond low Earth orbit (LEO) require that several strategic knowledge gaps about the effects of space travel on the human body be addressed. NASA Ames Research Center has been the leader in developing autonomous bio nanosatellites, including past successful missions for GeneSat, PharmaSat, and O/OREOS, that tackled some of these issues. These nanosatellites provide in situ measurements, which deliver insight into the dynamic changes in cell behavior in microgravity. In this talk, two upcoming bio nanosatellites developed at Ames, the E. coli Antimicrobial Satellite (EcAMSat) and BioSentinel, will be discussed. Both satellites contain microfluidic systems that precisely deliver nutrients to the microorganisms stored within wells of fluidic cards. Each well, in turn, has its own 3-color LED and detector system which is used to monitor changes in metabolic activity with alamarBlue, a redox indicator, and the optical density of the cells. EcAMSat investigates the effects of microgravity on bacterial resistance to antimicrobial drugs, vital knowledge for understanding how to maintain the health of astronauts in long-term and beyond LEO spaceflight. The behavior of wild type and mutant uropathic E. coli will be compared in microgravity and with ground data to help understand the molecular mechanisms behind antibiotic resistance and how these phenotypes might change in space. BioSentinel seeks to directly measure the effects of space radiation on budding yeast S. cerevisiae, particularly double strand breaks (DSB). While hitching a ride on the SLS EM-1 mission (Orion's first unmanned mission to the moon) in 2018, BioSentinel will be kicked off and enter into a heliocentric orbit, becoming the first study of the effects of radiation on living organisms outside LEO since the Apollo program. The yeast are stored in eighteen independent 16-well microfluidic cards, which will be individually activated over the 12 month mission duration. In addition to the wild type and radiation-sensitive mutant strains, a BioSentinel strain of yeast has been developed, which requires a DSB to reactivate growth, thereby allowing for a direct measurement of DSBs caused by radiation. These two missions demonstrate the utility of using autonomous nanosatellites to address strategic knowledge gaps in the push to once again extend manned spaceflight beyond LEO.

EcAMSat and BioSentinel: Autonomous Bio Nanosatellites Addressing Strategic Knowledge Gaps for Manned Spaceflight Beyond LEO

NASA Technical Reports Server (NTRS)

Padgen, Mike

2017-01-01

Manned missions beyond low Earth orbit (LEO) require that several strategic knowledge gaps about the effects of space travel on the human body be addressed. NASA Ames Research Center has been the leader in developing autonomous bio nanosatellites, including past successful missions for GeneSat, PharmaSat, and OOREOS, that tackled some of these issues. These nanosatellites provide in situ measurements, which deliver insight into the dynamic changes in cell behavior in microgravity. In this talk, two upcoming bio nanosatellites developed at Ames, the E. coli Antimicrobial Satellite (EcAMSat) and BioSentinel, will be discussed. Both satellites contain microfluidic systems that precisely deliver nutrients to the microorganisms stored within wells of fluidic cards. Each well, in turn, has its own 3-color LED and detector system which is used to monitor changes in metabolic activity with alamarBlue, a redox indicator, and the optical density of the cells. EcAMSat investigates the effects of microgravity on bacterial resistance to antimicrobial drugs, vital knowledge for understanding how to maintain the health of astronauts in long-term and beyond LEO spaceflight. The behavior of wild type and mutant uropathic E. coli will be compared in microgravity and with ground data to help understand the molecular mechanisms behind antibiotic resistance and how these phenotypes might change in space. BioSentinel seeks to directly measure the effects of space radiation on budding yeast S. cerevisiae, particularly double strand breaks (DSB). While hitching a ride on the SLS EM-1 mission (Orions first unmanned mission to the moon) in 2018, BioSentinel will be kicked off and enter into a heliocentric orbit, becoming the first study of the effects of radiation on living organisms outside LEO since the Apollo program. The yeast are stored in eighteen independent 16-well microfluidic cards, which will be individually activated over the 12 month mission duration. In addition to the wild type and radiation-sensitive mutant strains, a BioSentinel strain of yeast has been developed, which requires a DSB to reactivate growth, thereby allowing for a direct measurement of DSBs caused by radiation. These two missions demonstrate the utility of using autonomous nanosatellites to address strategic knowledge gaps in the push to once again extend manned spaceflight beyond LEO.

The pig-tailed monkey (Macaca nemestrina) as a space-flight candidate. [for cardiovascular studies

NASA Technical Reports Server (NTRS)

Pace, N.; Rahlmann, D. F.; Kodama, A. M.; Grunbaum, B. W.; Mains, R. C.

1977-01-01

Scientific attributes which make the pig-tailed monkey an optimal candidate for studing the nature of cardiovascular and respiratory adaptations in man during exposure to high altitutes for long periods of time include: a calm, quiet, patient temperament; a short tail and the presence of ischial callosities permitting comfortable seated restraint during long duration experiments; and the close phylogenetic relationships and comparable body size to man.

Cardiovascular adaptations in weightlessness: The influence of in-flight exercise programs on the cardiovascular adjustments during weightlessness and upon returning to Earth

NASA Technical Reports Server (NTRS)

Bennett, C. H.

1981-01-01

The effect of in-flight exercise programs on astronauts' cardiovascular adjustments during spaceflight weightlessness and upon return to Earth was studied. Physiological changes in muscle strength and volume, cardiovascular responses during the application of lower body negative pressure, and metabolic activities during pre-flight and flight tests were made on Skylab crewmembers. The successful completion of the Skylab missions showed that man can perform submaximal and maximal aerobic exercise in the weightless enviroment without detrimental trends in any of the physiologic data. Exercise tolerance during flight was unaffected. It was only after return to Earth that a tolerance decrement was noted. The rapid postflight recovery of orthostatic and exercise tolerance following two of the three Skylab missions appeared to be directly related to total in-flight exercise as well as to the graded, regular program of exercise performed during the postflight debriefing period.

The evolution of automation and robotics in manned spaceflight

NASA Technical Reports Server (NTRS)

Moser, T. L.; Erickson, J. D.

1986-01-01

The evolution of automation on all manned spacecraft including the Space Shuttle is reviewed, and a concept for increasing automation and robotics from the current Shuttle Remote Manipulator System (RMS) to an autonomous system is presented. The requirements for robotic elements are identified for various functions on the Space Station, including extravehicular functions and functions within laboratory and habitation modules which expand man's capacity in space and allow selected teleoperation from the ground. The initial Space Station will employ a telerobot and necessary knowledge based systems as an advisory to the crew on monitoring, fault diagnosis, and short term planning and scheduling.

ASTRONAUT GLENN, JOHN - MERCURY SPACE SUIT

NASA Image and Video Library

1962-02-20

S62-00965 (20 Feb. 1962) --- Astronaut John H. Glenn Jr., finishes suiting up, and prepares for the launch of his Mercury-Atlas 6 (MA-6) spacecraft. The MA-6 ?Friendship 7? mission marks America's first manned Earth-orbiting spaceflight. Photo credit: NASA

W.W.W. MOON? The why, what and when of a permanent manned lunar colony.

PubMed

Morabito, Maurizio

2005-01-01

Several reasons for going back to the Moon are listed: scientific study of our natural satellite, Earth and in general the Solar System; exploitation of the resources of Outer Space; geopolitical considerations that made Apollo possible and are still valid in the long term; advancement of manned spaceflight, as robot-based exploration is time-wise inefficient and politically negligible. Technological, organisational and legal challenges are then outlined. After a discussion of human physiology, building materials and transportation of people and goods, an underground polar location is proposed as settlement site, either within kilometre-size lava tubes or man-made caves. An analysis of spaceflight history is conducted to determine a target date for returning to the Moon to stay. In the absence of political or commercial competition, experience indicates the last decades of the XXI century. To shorten this timescale, it is recommended to focus on accomplishing the task of establishing a reliable lunar travel and settlement system, rather than developing new technologies: simplifying the goals of each single step forward (as was the case of the Clementine mission) and concentrating on production-ready (or almost-ready) equipment (compare the ill-fated X-33 to the dependable Soyuz capsules).

Apollo 7 prime crew during water egress training in Gulf of Mexico

NASA Technical Reports Server (NTRS)

1968-01-01

The prime crew of the first manned Apollo space mission, Apollo 7, participates in water egress training in the Gulf of Mexico. In hatch of the Apollo egress trainer (command module) is Astronaut Walter M. Schirra Jr., Sitting in life raft are Astronauts Walter Cunningham (on left) and Donn F. Eisele. A team of Manned Spaceflight Center swimmers assisted with the training exercise. The inflated bags were used to upright the trainer prior to egress.

Apollo 7 prime crew during water egress training in Gulf of Mexico

NASA Technical Reports Server (NTRS)

1968-01-01

The prime crew of the first manned Apollo space mission, Apollo 7, participates in water egress training in the Gulf of Mexico. Left to right, are Astronauts Walter M. Schirra Jr. (stepping into life raft); Donn F. Eisele, and Walter Cunningham. They have just egressed the Apollo Command Module Boilerplate 1102, and are awaiting helicopter pickup. Inflated bags were used to upright the boilerplate. Manned Spaceflight Center swimmers assisted in the training exercise.

Manned spaceflight in the nineties: The European perspective

NASA Technical Reports Server (NTRS)

Finke, W.

1985-01-01

The inaugural speech for the international space travel symposium which took place in Bad Godesberg, West Germany on 2 Oct. 1985 explains why Europe must take an active part in all aspects of manned space travel for the nineties, including the development of the space station itself and the development of its own reusable space transport and supporting ground equipment to proceed on an equal share basis with the US and Japan while maintaining close international cooperation.

Advanced manned space flight simulation and training: An investigation of simulation host computer system concepts

NASA Technical Reports Server (NTRS)

Montag, Bruce C.; Bishop, Alfred M.; Redfield, Joe B.

1989-01-01

The findings of a preliminary investigation by Southwest Research Institute (SwRI) in simulation host computer concepts is presented. It is designed to aid NASA in evaluating simulation technologies for use in spaceflight training. The focus of the investigation is on the next generation of space simulation systems that will be utilized in training personnel for Space Station Freedom operations. SwRI concludes that NASA should pursue a distributed simulation host computer system architecture for the Space Station Training Facility (SSTF) rather than a centralized mainframe based arrangement. A distributed system offers many advantages and is seen by SwRI as the only architecture that will allow NASA to achieve established functional goals and operational objectives over the life of the Space Station Freedom program. Several distributed, parallel computing systems are available today that offer real-time capabilities for time critical, man-in-the-loop simulation. These systems are flexible in terms of connectivity and configurability, and are easily scaled to meet increasing demands for more computing power.

KSC-2011-3326

NASA Image and Video Library

2011-05-05

CAPE CANAVERAL, Fla. -- Invited guests enjoy the program presented at a celebration at Complex 5/6 on Cape Canaveral Air Force Station in Florida. The celebration was held at the launch site of the first U.S. manned spaceflight May 5, 1961, to mark the 50th anniversary of the flight. Fifty years ago, astronaut Alan Shepard lifted off inside the Mercury capsule, "Freedom 7," atop an 82-foot-tall Mercury-Redstone rocket at 9:34 a.m. EST, sending him on a remarkably successful, 15-minute suborbital flight. The event was attended by more than 200 workers from the original Mercury program and included a re-creation of Shepard's flight and recovery, as well as a tribute to his contributions as a moonwalker on the Apollo 14 lunar mission. For more information, visit www.nasa.gov/topics/history/milestones/index.html. Photo credit: NASA/Kim Shiflett

Orion Navigation Sensitivities to Ground Station Infrastructure for Lunar Missions

NASA Technical Reports Server (NTRS)

Getchius, Joel; Kukitschek, Daniel; Crain, Timothy

2008-01-01

The Orion Crew Exploration Vehicle (CEV) will replace the Space Shuttle and serve as the next-generation spaceship to carry humans to the International Space Station and back to the Moon for the first time since the Apollo program. As in the Apollo and Space Shuttle programs, the Mission Control Navigation team will utilize radiometric measurements to determine the position and velocity of the CEV. In the case of lunar missions, the ground station infrastructure consisting of approximately twelve stations distributed about the Earth and known as the Apollo Manned Spaceflight Network, no longer exists. Therefore, additional tracking resources will have to be allocated or constructed to support mission operations for Orion lunar missions. This paper examines the sensitivity of Orion navigation for lunar missions to the number and distribution of tracking sites that form the ground station infrastructure.

Evaluating Failures and Near Misses in Human Spaceflight History for Lessons for Future Human Spaceflight

NASA Technical Reports Server (NTRS)

Barr, Stephanie

2009-01-01

There have been a number of studies done in the past drawn on lessons learned with regard to human loss-of-life events. Generally, the systemic causes and proximate causes for fatal events have both been examined in considerable detail. However, an examination of near-fatal accidents and failures that narrowly missed being fatal could be equally useful, not only in detecting causes, both proximate and systemic, but also for determining what factors averted disaster, what design decisions and/or operator actions prevented catastrophe. Additionally, review of risk factors for upcoming or future programs will often look at trending statistics, generally focusing on failure/success statistics. Unfortunately, doing so can give a skewed or misleading view of past reliability or a reliability that cannot be presumed to apply to a new program. One reason for this might be that failure/success criteria aren't the same across programs, but also that apparent success can hide systemic faults that, under other circumstances, can be fatal to a program with different parameters. A program with a number of near misses can look more reliable than a consistently healthy program with a single out-of-family failure and provide very misleading data if it is not examined in detail. This is particularly true for a manned space program where failure/success includes more than making a particular orbit. Augmenting reliability evaluations with this near miss data can provide insight and expand on the limitations of a strictly pass/fail evaluation. Even more importantly, a thorough understanding of these near miss events can identify conditions that prevented fatalities. Those conditions may be key to a programs reliability, but, without insight to the repercussions if such conditions were not in place, their importance may not be readily clear. As programs mature and political and fiscal responsibilities come to the fore, often there is considerable incentive to eliminate unnecessary conservatism, design margin, redundancy, operational support, testing, training, or safety oversight. An evaluation that demonstrates how these features and capabilities averted disaster can ensure processes that saved lives or missions are not discarded without appropriate review and understanding. Close examination of accidents that almost were can also highlight differences in design from one program to another, either justifying reliability comparisons or negating them. It can also provide considerable insight into how those saving factors were developed and implemented so that similar methods can be used to ensure appropriate life-saving and mission saving factors can be developed, even for a dissimilar space program. The lessons are appropriate for seasoned manned space programs and agencies, but crucial for untried agencies and organizations that are interested in sending man into space. The large body of publicly available near miss and accident data available provide invaluable insight into programmatic, technical, and even political issues that can be addressed before they impact safety. In this paper, we examine a number of these near misses and accidents and steps a program, agency, or potential spacefaring company might take to improve their chances of success and avoid mission or safety disasters using this data.

NASA Central Operation of Resources for Educators (CORE): Educational Materials Catalog

NASA Technical Reports Server (NTRS)

1999-01-01

This catalog contains order information for video cassettes with topics such as: aeronautics, earth science, weather, space exploration/satellites, life sciences, energy, living in space, manned spaceflight, social sciences, space art, space sciences, technology education and utilization, and mathematics/physics.

Biomedical research

NASA Technical Reports Server (NTRS)

1981-01-01

Biomedical problems encountered by man in space which have been identified as a result of previous experience in simulated or actual spaceflight include cardiovascular deconditioning, motion sickness, bone loss, muscle atrophy, red cell alterations, fluid and electrolyte loss, radiation effects, radiation protection, behavior, and performance. The investigations and the findings in each of these areas were reviewed. A description of how biomedical research is organized within NASA, how it is funded, and how it is being reoriented to meet the needs of future manned space missions is also provided.

Particle trajectories in seeds of Lactuca sativa and chromosome aberrations after exposure to cosmic heavy ions on cosmos biosatellites 8 and 9

NASA Astrophysics Data System (ADS)

Facius, R.; Scherer, K.; Reitz, G.; Bücker, H.; Nevzgodina, L. V.; Maximova, E. N.

1994-10-01

The potentially specific importance of the heavy ions of the galactic cosmic radiation for radiation protection in manned spaceflight continues to stimulate in situ, i.e., spaceflight experiments to investigate their radiobiological properties. Chromosome aberrations as an expression of a direct assault on the genome are of particular interest in view of cancerogenesis being the primary radiation risk for man in space. In such investigations the establishment of the geometrical correlation between heavy ions' trajectories and the location of radiation sensitive biological substructures is an essential task. The overall qualitative and quantitative precision achieved for the identification of particle trajectories in the order of 2~10 μm as well as the contributing sources of uncertainties are discussed. We describe how this was achieved for seeds of Lactuca sativa as biological test organisms, whose location and orientation had to be derived from contact photographies displaying their outlines and those of the holder plates only. The incidence of chromosome aberrations in cells exposed during the COSMOS 1887 (Biosatellite 8) and the COSMOS 2044 (Biosatellite 9) mission was determined for seeds hit by cosmic heavy ions. In those seeds the incidence of both single and multiple chromosome aberrations was enhanced. The results of the Biosatellite 9 experiment, however, are confounded by spaceflight effects unrelated to the passage of heavy ions.

Experiment K-7-35: Circadian Rhythms and Temperature Regulation During Spaceflight. Part 2; Metabolism

NASA Technical Reports Server (NTRS)

Fuller, C. A.; Dotsenko, M. A.; Korolkov, V. I.; Griffin, D. W.; Stein, T. P.

1994-01-01

Energy expenditure can be regarded as the sum of two components; the basal metabolic rate and the energy costs of activity. Weight loss is usually associated with an energy deficit. A negative energy balance exists when energy intake is less that energy utilization. The deficit is made up by tissue catabolism (principally fat, but also some protein). By analyzing food and water intake, urine and fecal output, and changes in body weight, the Skylab investigators reached the unexpected conclusion that energy expenditure during spaceflight was about 5% greater than at 1 G (Leonard, 1983; Rambaut et al., 1977). Possible explanations for the human metabolic responses are an increased workload during spaceflight (Leonard, 1983), or as Rambaut and co-workers (1977) suggested, a progressive decrease in metabolic efficiency. It is likely to be very difficult to distinguish between these two possibilities in man because the activity component may be different during spaceflight than it is the ground. The problem is to measure energy expenditure with efficient precision during spaceflight in a non-invasive manner which will not interfere with other investigations or take an time. The doubly labeled water (DLW) method meets these criteria. The DLW method is the only method available for continuously measuring energy expenditure during spaceflight given the severely restricted conditions in the spaceflight environment. Therefore, this study focuses on the development and use of this procedure on nonhuman primates during spaceflight. Energy expenditure and total body water was determined in two Rhesus monkeys by the doubly labeled water (2H2'80) method. Three determinations were made. Monkey B (#2483) was studied twice, during the flight of COSMOS 2044 and during a follow-up ground control study a month later. A second monkey was studied on the ground only (Monkey D, #782).

Microgravity as a biological tool to examine host-pathogen interactions and to guide development of therapeutics and preventatives that target pathogenic bacteria.

PubMed

Higginson, Ellen E; Galen, James E; Levine, Myron M; Tennant, Sharon M

2016-11-01

Space exploration programs have long been interested in the effects of spaceflight on biology. This research is important not only in its relevance to future deep space exploration, but also because it has allowed investigators to ask questions about how gravity impacts cell behavior here on Earth. In the 1980s, scientists designed and built the first rotating wall vessel, capable of mimicking the low shear environment found in space. This vessel has since been used to investigate growth of both microorganisms and human tissue cells in low shear modeled microgravity conditions. Bacterial behavior has been shown to be altered both in space and under simulated microgravity conditions. In some cases, bacteria appear attenuated, whereas in others virulence is enhanced. This has consequences not only for manned spaceflight, but poses larger questions about the ability of bacteria to sense the world around them. By using the microgravity environment as a tool, we can exploit this phenomenon in the search for new therapeutics and preventatives against pathogenic bacteria for use both in space and on Earth. © FEMS 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

The Complete Book of Spaceflight: From Apollo 1 to Zero Gravity

NASA Astrophysics Data System (ADS)

Darling, David

2002-11-01

A commanding encyclopedia of the history and principles of spaceflight-from earliest conceptions to faster-than-light galaxy-hopping Here is the first truly comprehensive guide to space exploration and propulsion, from the first musings of the Greeks to current scientific speculation about interstellar travel using "warp drives" and wormholes. Space buffs will delight in its in-depth coverage of all key manned and unmanned missions and space vehicles-past, present, and projected-and its clear explanations of the technologies involved. Over the course of more than 2,000 extensively cross-referenced entries, astronomer David Darling also provides fascinating insights into the cultural development of spaceflight. In vivid accounts of the major characters and historical events involved, he provides fascinating tales of early innovators, the cross-pollination that has long existed between science fiction and science fact, and the sometimes obscure links between geopolitics, warfare, and advances in rocketry.

Orion: Design of a system for assured low-cost human access to space

NASA Technical Reports Server (NTRS)

Elvander, Josh; Heifetz, Andy; Hunt, Teresa; Zhu, Martin

1994-01-01

In recent years, Congress and the American people have begun to seriously question the role and importance of future manned spaceflight. This is mainly due to two factors: a decline in technical competition caused by the collapse of communism, and the high costs associated with the Space Shuttle transportation system. With these factors in mind, the ORION system was designed to enable manned spaceflight at a low cost, while maintaining the ability to carry out diverse missions, each with a high degree of flexibility. It is capable of performing satellite servicing missions, supporting a space station via crew rotation and resupply, and delivering satellites into geosynchronous orbit. The components of the system are a primary launch module, an upper stage, and a manned spacecraft capable of dynamic reentry. For satellite servicing and space station resupply missions, the ORION system utilizes three primary modules, an upper stage, and the spacecraft, which is delivered to low earth orbit and used to rendezvous, transfer materials, and make repairs. For launching a geosynchronous satellite, one primary module and an upper stage are used to deliver the satellite, along with an apogee kick motor, into orbit. The system is designed with reusability and modularity in mind in an attempt to lower cost.

Launch Pad Escape System Design (Human Spaceflight)

NASA Technical Reports Server (NTRS)

Maloney, Kelli

2011-01-01

A launch pad escape system for human spaceflight is one of those things that everyone hopes they will never need but is critical for every manned space program. Since men were first put into space in the early 1960s, the need for such an Emergency Escape System (EES) has become apparent. The National Aeronautics and Space Administration (NASA) has made use of various types of these EESs over the past 50 years. Early programs, like Mercury and Gemini, did not have an official launch pad escape system. Rather, they relied on a Launch Escape System (LES) of a separate solid rocket motor attached to the manned capsule that could pull the astronauts to safety in the event of an emergency. This could only occur after hatch closure at the launch pad or during the first stage of flight. A version of a LES, now called a Launch Abort System (LAS) is still used today for all manned capsule type launch vehicles. However, this system is very limited in that it can only be used after hatch closure and it is for flight crew only. In addition, the forces necessary for the LES/LAS to get the capsule away from a rocket during the first stage of flight are quite high and can cause injury to the crew. These shortcomings led to the development of a ground based EES for the flight crew and ground support personnel as well. This way, a much less dangerous mode of egress is available for any flight or ground personnel up to a few seconds before launch. The early EESs were fairly simple, gravity-powered systems to use when thing's go bad. And things can go bad very quickly and catastrophically when dealing with a flight vehicle fueled with millions of pounds of hazardous propellant. With this in mind, early EES designers saw such a passive/unpowered system as a must for last minute escapes. This and other design requirements had to be derived for an EES, and this section will take a look at the safety design requirements had to be derived for an EES, and this section will take a look at the safety design aspects for a launch pad escape system.

The Cambridge encyclopedia of space (revised edition)

NASA Technical Reports Server (NTRS)

D'Allest, Frederic; Arets, Jean; Baker, Phillip J.; Balmino, Georges; Barth, Hans; Benson, Robert H.

1990-01-01

A comprehensive and intensively illustrated development history is presented for spaceflight, ranging over its basic concepts' speculative and fictional origins, the historical roots of rocket-related technologies, and the scientific accomplishments of earth orbit and interplanetary missions to date. Attention is given to propulsion systems, spaceflight launch centers, satellite systems, and solar system exploration by the U.S. and the Soviet Union. Current space-related activities encompass the meteorology, remote sensing, telecommunications and direct broadcasting, and navigation functions of unmanned satellites, as well as such manned spacecraft roles as medical and materials science research. The military uses of space, and increasingly important space industrialization concepts, are discussed as well.

Hormonal regulation of fluid and electrolyte metabolism in zero-g and bedrest

NASA Technical Reports Server (NTRS)

Vernikos, Joan

1991-01-01

The study of man in spaceflight has consistently indicated changes in fluid and electrolyte balance. Sodium (Na), Potassium (K), and Calcium (Ca) excretion are increased, accompanied by changes in the levels and responsiveness of adrenal hormones and the sympathetic nervous system (SNS). These hormones and neurohumors are critical to the regulation of blood pressure, blood flow, and blood volume. The primary objectives of the research conducted under this task have been to use -6 deg head down bedrest (BR) as the analog to spaceflight, to determine the long term changes in these systems, their relationship to orthostatic tolerance, and to develop and test suitable countermeasures.

An overview of Ball Aerospace cryogen storage and delivery systems

NASA Astrophysics Data System (ADS)

Marquardt, J.; Keller, J.; Mills, G.; Schmidt, J.

2015-12-01

Starting on the Gemini program in the 1960s, Beech Aircraft (now Ball Aerospace) has been designing and manufacturing dewars for a variety of cryogens including liquid hydrogen and oxygen. These dewars flew on the Apollo, Skylab and Space Shuttle spacecraft providing fuel cell reactants resulting in over 150 manned spaceflights. Since Space Shuttle, Ball has also built the liquid hydrogen fuel tanks for the Boeing Phantom Eye unmanned aerial vehicle. Returning back to its fuel cell days, Ball has designed, built and tested a volume-constrained liquid hydrogen and oxygen tank system for reactant delivery to fuel cells on unmanned undersea vehicles (UUVs). Herein past history of Ball technology is described. Testing has been completed on the UUV specific design, which will be described.

Lawmakers battle for reform on many fronts.

PubMed

Dorr, Robert F

2003-11-01

In Washington, much of the attention of the nation's leaders is focused on the economy, on next year's election, and on the war's aftermath in Iraq. Polls show that a restive nation wants more jobs and fewer casualties in the war on terror. In the world of aerospace, few topics seem to be headline-grabbers lately, but the lawmakers are always working on air and space issues--some of them very familiar to Americans. The U.S. program for manned spaceflight remains controversial and a firm date for a return to flight elusive. The little-known air war in Colombia is receiving more attention than many in Washington would like. And the Air Force plan to lease air-refueling tankers continues to draw flak from the Hill.

Astronaut Alan B. Shepard has his blood pressure and temperature checked

NASA Image and Video Library

1961-01-01

S61-02740 (5 May 1961) --- Astronaut Alan B. Shepard Jr. has his heart rate checked prior to his Mercury-Redstone 3 (MR-3) mission, the first American manned suborbital spaceflight. The attending physician is Dr. William K. Douglas. Photo credit: NASA or National Aeronautics and Space Administration

Using the brain's fight-or-flight response for predicting mental illness on the human space flight program

NASA Astrophysics Data System (ADS)

Losik, L.

A predictive medicine program allows disease and illness including mental illness to be predicted using tools created to identify the presence of accelerated aging (a.k.a. disease) in electrical and mechanical equipment. When illness and disease can be predicted, actions can be taken so that the illness and disease can be prevented and eliminated. A predictive medicine program uses the same tools and practices from a prognostic and health management program to process biological and engineering diagnostic data provided in analog telemetry during prelaunch readiness and space exploration missions. The biological and engineering diagnostic data necessary to predict illness and disease is collected from the pre-launch spaceflight readiness activities and during space flight for the ground crew to perform a prognostic analysis on the results from a diagnostic analysis. The diagnostic, biological data provided in telemetry is converted to prognostic (predictive) data using the predictive algorithms. Predictive algorithms demodulate telemetry behavior. They illustrate the presence of accelerated aging/disease in normal appearing systems that function normally. Mental illness can predicted using biological diagnostic measurements provided in CCSDS telemetry from a spacecraft such as the ISS or from a manned spacecraft in deep space. The measurements used to predict mental illness include biological and engineering data from an astronaut's circadian and ultranian rhythms. This data originates deep in the brain that is also damaged from the long-term exposure to cortisol and adrenaline anytime the body's fight or flight response is activated. This paper defines the brain's FOFR; the diagnostic, biological and engineering measurements needed to predict mental illness, identifies the predictive algorithms necessary to process the behavior in CCSDS analog telemetry to predict and thus prevent mental illness from occurring on human spaceflight missions.

The moon as a stepping stone for a spacefaring civilization

NASA Astrophysics Data System (ADS)

Multhaup, K.

2008-09-01

After Columbia In early 2004, U.S. president George Bush introduced the Vision for Space Exploration (VSE). Conceived in the aftermath of the Columbia tragedy, it called for NASA to first return astronauts to the moon by 2020 and then send crews to Mars and beyond thereafter. Bush's plan has once again enlivened the long-lasting discussion of manned spaceflight vs. robotic exploration. Also, the plan to use the moon as a stepping stone has come under scrutiny and is being debated. Alternate approaches minimizing or deleting manned lunar exploration in the frame of the VSE were proposed. Fig. 1 A composite manned spacecraft departing Earth orbit en route to the moon. Image: NASA. In order to assess the value of us going back to the moon, it is necessary to debate without bias the meaning of human spaceflight in general and to discuss the role of science in future efforts. Lunar disenchantment Whithin the scientific community, manned exploration programs are put into question time and again. It is demanded that in light of supposedly immense costs any endeavour concerning this matter shall be justified by an indisputable scientific return — and in current debates, scientific value is not recognized in such a way that funding appears well-invested. It is lamented that funds are drawn from what is considered real science. In the past, robotic exploration has opended our eyes to the many wonders of the solar system. Through the eyes of Cassini , Mars Express, and other successful spacecraft, we have seen exotic landscapes—yet on second sight, some appeared all too familiar. BepiColombo will fly to Mercury to unravel its mysteries and the Jovian system may receive a new earthly visitor in the not too distant future. By means of machines like Spirit and Opportunity, we have roamed the surfaces of Mars—without actually ever setting foot there. Therefore, the question is often asked, "Why send crews?" Fig. 2 The upcoming Lunar Reconnisance Orbiter (LRO) as it circles the moon. Robotic spacecraft deliver science for a fraction of the costs of manned exploration. Is this reason enough to question the presence of man in space? Image: NASA. But even among those who basically support the concept of manned exploration, the decision to use the moon as our next destination and stepping stone is challenged. It is feared by some that manned lunar exploration in particular will bog down the space program for decades to come and eventually inhibit human exploration of Mars. Refutation of arguments Both science and exploration have their roots in the human desire to evolve and expand. But if the virtue of human spaceflight is assessed in view of scientific return only, then the question must also be allowed what purpose planetary science has. What do we, the community of planetary scientists, do to benefit mankind? I see two tiers in planetary science. One of them—the well established approach—is to learn about the planets in order to understand our own homeworld and the place that it takes in the solar system. A great many basic questions from this research theme can be answered by theorizing, by observing from the ground, and by sending unmanned spacecraft. But robots can only do so much … In this tier, human spaceflight admittedly is not required, but more than acutely helpful. A geologist EPSC Abstracts, Vol. 3, EPSC2008-A-xxxx, 2008 European Planetary Science Congress, Author(s) 2008 EPSC Abstracts, Vol. 3, EPSC2008-A-00023, 2008 European Planetary Science Congress, Author(s) 2008 walking around on the surface of Mars will possibly learn more about the planet in a day's work than an automated rover slowly crawling from rock to rock in a couple of years. Nonetheless, the billions and billions of dollars that are required to conduct such programs can hardly be justified exclusively by science. Technology will evolve and the quality and quantity of science return from robotic missions will increase. Fig. 3 The proposed Altair lander sitting on the surface of the moon. It will enable astronauts to pick up where Harrison Schmitt—the first (and to date last) geologist to walk on the moon—left off in 1972. Image: NASA. In the second tier though, the focus of science shifts away from basic understanding. We shall apply our scientific knowledge and use it to settle on other worlds. Why? Simply because we are an exploratory species! Human exploration of the solar system does not need to be justified by science. This misjudgement is with us ever since we first discussed the true value of Apollo. The concept of man in space is of paramount importance in itself. Not many will adapt this view. But there is more. Carl Sagan wrote: "… every surviving civilization is obliged to become spacefaring—not because of exploratory or romantic zeal, but for the most practical reason imaginable: staying alive." In this context, understanding how the planets, moons and asteroids work will be a key to becoming true solar system dwellers and protect our well-being against selfimposed threats or cosmic catastrophes. The moon as a stepping stone Maybe the timing of the Apollo program was a mistake. We took the second step well before the first. The first step should have been establishing ourselves in low Earth orbit. Now we are in the process of doing so—although the sheer impact of our early "giant leap" has made it difficult for NASA over the years to sell less ambitious programs to the various adminsitrations of the U.S. and to the public. Or to the scientific community. Of course, the shuttle and ISS programs do not serve exploration per se. "That's not exploration; that's like driving a bus over the same highway two hundred miles," the above cited Sagan also said. But through the shuttle and the station that we built using it, we are learning how to live and work in space. Fig. 4 Today's astronauts are living and working in low Earth orbit. Image: NASA. Now, we are ready for the second step. While we could also go to Mars without setting foot on the moon again, we ought to follow an expedient sequence of steps that will allow us to evolve and stage a sound exploration program. The new Constellation program hopefully will do what Apollo could not achieve. Yes, returning man to the moon will be expensive. It will cost money and time. So will expeditions to Mars. But do we really wish to discuss the price tag of destiny in space? Or survival? Fig. 5 Footprint in the lunar surface. Are we ready to accept the inheritance of Apollo? Image: NASA. Closure Manned exploration will both push frontiers and expand knowlegde, just as science will enable us to understand the nature of these frontiers. The human future in space will be built on these foundations. While the moon in itself will be a rewarding destination to concentrate our upcoming exploration efforts on, it will also serve as an excellent technological testbed for our further steps out—maybe to Mars or to the asteroids.

Medical Implications of Space Radiation Exposure Due to Low-Altitude Polar Orbits.

PubMed

Chancellor, Jeffery C; Auñon-Chancellor, Serena M; Charles, John

2018-01-01

Space radiation research has progressed rapidly in recent years, but there remain large uncertainties in predicting and extrapolating biological responses to humans. Exposure to cosmic radiation and solar particle events (SPEs) may pose a critical health risk to future spaceflight crews and can have a serious impact on all biomedical aspects of space exploration. The relatively minimal shielding of the cancelled 1960s Manned Orbiting Laboratory (MOL) program's space vehicle and the high inclination polar orbits would have left the crew susceptible to high exposures of cosmic radiation and high dose-rate SPEs that are mostly unpredictable in frequency and intensity. In this study, we have modeled the nominal and off-nominal radiation environment that a MOL-like spacecraft vehicle would be exposed to during a 30-d mission using high performance, multicore computers. Projected doses from a historically large SPE (e.g., the August 1972 solar event) have been analyzed in the context of the MOL orbit profile, providing an opportunity to study its impact to crew health and subsequent contingencies. It is reasonable to presume that future commercial, government, and military spaceflight missions in low-Earth orbit (LEO) will have vehicles with similar shielding and orbital profiles. Studying the impact of cosmic radiation to the mission's operational integrity and the health of MOL crewmembers provides an excellent surrogate and case-study for future commercial and military spaceflight missions.Chancellor JC, Auñon-Chancellor SM, Charles J. Medical implications of space radiation exposure due to low-altitude polar orbits. Aerosp Med Hum Perform. 2018; 89(1):3-8.

Astronaut John Young hoisted aboard helicopter during water egress training

NASA Technical Reports Server (NTRS)

1966-01-01

Astronauts John W. Young, Gemini 10 command pilot, is hoisted up to a U.S. Coast Guard helicopter during water egress training in the Gulf of Mexico. A team of Manned Spaceflight Center (MSC) swimmers assists in the exercise. The Static Article 5 spacecraft can be seen in the water.

Can America Afford to Modernize the Air Force? An Examination of Domestic Factors Influencing Future Defense Budgets

DTIC Science & Technology

2009-02-12

like none at all—it will cost you dough and win you nothing. -- General George Kenney, first commander of Strategic Air Command...1950s and 1960s which played a significant role in such innovations as manned spaceflight, computers, and new manufacturing processes. Many of these

Astronaut John Glenn - Crew Quarters - Prelaunch - Cape

NASA Image and Video Library

1962-02-20

S62-00377 (20 Feb. 1962) --- Astronaut John H. Glenn Jr., walking out of building with Dr. William K. Douglas (to Glenn's left), and Joe W. Schmitt, NASA's suit technician (in front of Dr. Douglas). This Mercury Atlas 6 (MA-6) ?Friendship 7? flight marks America's first manned Earth-orbiting spaceflight. Photo credit: NASA

Astronaut Alan B. Shepard has his blood pressure and temperature checked

NASA Image and Video Library

1961-01-01

S61-02749 (5 May 1961) --- Astronaut Alan B. Shepard Jr. has his blood pressure and temperature checked prior to his Mercury-Redstone 3 (MR-3) mission, the first American manned spaceflight. The attending physician is Dr. William K. Douglas. Photo credit: NASA or National Aeronautics and Space Administration

Gemini 11 prime crew during water egress training in Gulf of Mexico

NASA Technical Reports Server (NTRS)

1966-01-01

Astronauts Charles Conrad Jr. (left) and Richard F. Gordon Jr. (right), prime crew for Gemini 11 space flight, practice water egress procedures in the Gulf of Mexico. Static Article 5 was used in the training exercise. A Manned Spaceflight Center (MSC) swimmer is in the water assisting in the training.

Astronaut - Shepard - MR-3

NASA Image and Video Library

1961-01-01

S61-02785 (5 May 1961) --- Astronaut Alan B. Shepard Jr. in his pressure suit is seated in a reclining chair while a technician checks communications equipment in his helmet. He is in the suiting trailer before the Mercury-Redstone 3 (MR-3) flight, the first American manned spaceflight. Photo credit: NASA or National Aeronautics and Space Administration

Effects of Simulated Microgravity on Functions of Neutrophil-like HL-60 Cells

NASA Astrophysics Data System (ADS)

Wang, Chengzhi; Li, Ning; Zhang, Chen; Sun, Shujin; Gao, Yuxin; Long, Mian

2015-11-01

Altered gravity, especially microgravity affects cellular functions of immune cells and can result in immune dysfunction for long-term, manned spaceflight and space exploration. The underlying mechanism, however, of sensing and responding to the gravity alteration is poorly understood. Here, a rotary cell culture system (RCCS) bioreactor was used to elucidate the effects of simulated microgravity on polymorphonuclear neutrophils (PMN)-like HL-60 cells. Alteration of cell morphology, up-regulation of (nitric oxide) NO production, enhancement of interleukin-6 (IL-6), interleukin-8 (IL-8), and monocyte chemotactic protein 1 (MCP-1) secretion, and diversity of cellular adhesion molecule expression were observed for the cells cultured in RCCS, leading to the up-regulated inflammatory immune responses and host defense. It was also indicated that such alterations in biological responses of PMNs mediated the reduced rolling velocity and decreased adhesion of PMN-like HL-60 cells on endothelial cells under shear flow. This work furthers the understandings in the effects and mechanism of microgravity on PMN functions, which are potentially helpful for optimizing the countermeasures to immune suppression in the future long-term, manned spaceflight.

Psychophysiological investigations of the biomedical problems of manned spaceflight

NASA Technical Reports Server (NTRS)

1993-01-01

The Final Report on psychophysiological investigations of the biomedical problems of manned spaceflight is presented. In the first project, statistical analyses of human autonomic data were performed. The objectives were the following: to establish a relational data base containing human psychophysiological data obtained from Shuttle flight experiments and ground-based research over a 20 year period; to enable multi-user access and retrieval of these data for subsequent analyses and for possible inclusion in the proposed Life Sciences Data Archive; and to enable/conduct statistical analyses across several experiments on large subject populations which can thereby provide definitive answers to questions on human autonomic and behavioral responses and adaptation to environmental stressors on Earth and in space. The second project studied motion sickness. The objectives were: to test/develop hardware and procedures to be incorporated into preflight training of crewmembers of Spacelab-J; and to examine spin-off applications of AFT. The third project studied orthostatic intolerance. The objective was to test the feasibility of applying autogenic-feedback training as a potential treatment for postflight orthostatic intolerance.

Building a Shared Definitional Model of Long Duration Human Spaceflight

NASA Technical Reports Server (NTRS)

Arias, Diana; Orr, Martin; Whitmire, Alexandra; Leveton, Lauren; Sandoval, Luis

2012-01-01

Objective: To establish the need for a shared definitional model of long duration human spaceflight, that would provide a framework and vision to facilitate communication, research and practice In 1956, on the eve of human space travel, Hubertus Strughold first proposed a "simple classification of the present and future stages of manned flight" that identified key factors, risks and developmental stages for the evolutionary journey ahead. As we look to new destinations, we need a current shared working definitional model of long duration human space flight to help guide our path. Here we describe our preliminary findings and outline potential approaches for the future development of a definition and broader classification system

Evolution of Space Shuttle Range Safety Ascent Flight Envelope Design

NASA Technical Reports Server (NTRS)

Brewer, Joan; Davis, Jerel; Glenn, Christopher

2011-01-01

For every space vehicle launch from the Eastern Range in Florida, the range user must provide specific Range Safety (RS) data products to the Air Force's 45th Space Wing in order to obtain flight plan approval. One of these data products is a set of RS ascent flight envelope trajectories that define the normal operating region of the vehicle during powered flight. With the Shuttle Program launching 135 manned missions over a 30-year period, 135 envelope sets were delivered to the range. During this time, the envelope methodology and design process evolved to support mission changes, maintain high data quality, and reduce costs. The purpose of this document is to outline the shuttle envelope design evolution and capture the lessons learned that could apply to future spaceflight endeavors.

CCSDS telemetry systems experience at the Goddard Space Flight Center

NASA Technical Reports Server (NTRS)

Carper, Richard D.; Stallings, William H., III

1990-01-01

NASA Goddard Space Flight Center (GSFC) designs, builds, manages, and operates science and applications spacecraft in near-earth orbit, and provides data capture, data processing, and flight control services for these spacecraft. In addition, GSFC has the responsibility of providing space-ground and ground-ground communications for near-earth orbiting spacecraft, including those of the manned spaceflight programs. The goal of reducing both the developmental and operating costs of the end-to-end information system has led the GSFC to support and participate in the standardization activities of the Consultative Committee for Space Data Systems (CCSDS), including those for packet telemetry. The environment in which such systems function is described, and the GSFC experience with CCSDS packet telemetry in the context of the Gamma-Ray Observatory project is discussed.

Evaluation of possible interaction among drugs contemplated for use during manned space flights. Part 1: Summary from progress report dated 31 October 1973. Part 2: Progress report for the period November 1973 to June 1974

NASA Technical Reports Server (NTRS)

1974-01-01

Possible interactions among drugs contemplated for use during manned spaceflights have been studied in several animal species. The following seven drugs were investigated: nitrofurantoin, chloral hydrate, hexobarbital, phenobarbital, flurazepam, diphenoxylate, and phenazopyridine. Particular combinations included: chloral hydrate, hexobarbital or flurazepam with nitrofurantoin; phenobarbital or flurazepam with phenazopyridine; and diphenoxylate with two dose formulations of nitrofurantoin. The mechanism of action and an explanation of the interaction between diphenoxylate and nitrofurantoin still remains unclear. In man, the interaction does not appear to be significant, affecting only two subjects out of six and with only one dose formulation (Furadantin).

Anesthesia during and Immediately after Spaceflight

NASA Technical Reports Server (NTRS)

Seubert, Christoph N.; Price, Catherine; Janelle, Gregory M.

2006-01-01

The increasing presence of humans in space and long-duration manned missions to the Moon or Mars pose novel challenges to the delivery of medical care. Even now, cumulative person-days in space exceed 80 years and preparations for a return to the Moon are actively underway. Medical care after an emergent de-orbit or an accident during a non-nominal landing must not only address the specific disease or injuries but also the challenges posed by physiologic adaptations to microgravity. In the highly autonomous situation of a long-term space mission the situation is even more complex, because personnel, equipment, specific training, and clinical experience are by definition limited. To summarize our current knowledge specifically for anesthetic care during and immediately after spaceflight, we will review physiologic adaptations to microgravity with particular emphasis on the resulting anesthetic risks, discuss veterinary experiences with anesthesia in weightlessness or in animals adapted to microgravity, describe current research that pertains to anesthesia and spaceflight and point out unresolved questions for future investigation.

Organic Contamination Baseline Study in NASA Johnson Space Center Astromaterials Curation Laboratories

NASA Technical Reports Server (NTRS)

Calaway, Michael J.; Allen, Carlton C.; Allton, Judith H.

2014-01-01

Future robotic and human spaceflight missions to the Moon, Mars, asteroids, and comets will require curating astromaterial samples with minimal inorganic and organic contamination to preserve the scientific integrity of each sample. 21st century sample return missions will focus on strict protocols for reducing organic contamination that have not been seen since the Apollo manned lunar landing program. To properly curate these materials, the Astromaterials Acquisition and Curation Office under the Astromaterial Research and Exploration Science Directorate at NASA Johnson Space Center houses and protects all extraterrestrial materials brought back to Earth that are controlled by the United States government. During fiscal year 2012, we conducted a year-long project to compile historical documentation and laboratory tests involving organic investigations at these facilities. In addition, we developed a plan to determine the current state of organic cleanliness in curation laboratories housing astromaterials. This was accomplished by focusing on current procedures and protocols for cleaning, sample handling, and storage. While the intention of this report is to give a comprehensive overview of the current state of organic cleanliness in JSC curation laboratories, it also provides a baseline for determining whether our cleaning procedures and sample handling protocols need to be adapted and/or augmented to meet the new requirements for future human spaceflight and robotic sample return missions.

Rapid Electrochemical Detection and Identification of Microbiological and Chemical Contaminants for Manned Spaceflight Project

NASA Technical Reports Server (NTRS)

Pierson, Duane; Botkin, Douglas; Gazda, Daniel

2014-01-01

Microbial control in the spacecraft environment is a daunting task, especially in the presence of human crew members. Currently, assessing the potential crew health risk associated with a microbial contamination event requires return of representative environmental samples that are analyzed in a ground-based laboratory. It is therefore not currently possible to quickly identify microbes during spaceflight. This project addresses the unmet need for spaceflight-compatible microbial identification technology. The electrochemical detection and identification platform is expected to provide a sensitive, specific, and rapid sample-to-answer capability for in-flight microbial monitoring that can distinguish between related microorganisms (pathogens and non-pathogens) as well as chemical contaminants. This will dramatically enhance our ability to monitor the spacecraft environment and the health risk to the crew. Further, the project is expected to eliminate the need for sample return while significantly reducing crew time required for detection of multiple targets. Initial work will focus on the optimization of bacterial detection and identification. The platform is designed to release nucleic acids (DNA and RNA) from microorganisms without the use of harmful chemicals. Bacterial DNA or RNA is captured by bacteria-specific probe molecules that are bound to a microelectrode, and that capture event can generate a small change in the electrical current (Lam, et al. 2012. Anal. Chem. 84(1): 21-5.). This current is measured, and a determination is made whether a given microbe is present in the sample analyzed. Chemical detection can be accomplished by directly applying a sample to the microelectrode and measuring the resulting current change. This rapid microbial and chemical detection device is designed to be a low-cost, low-power platform anticipated to be operated independently of an external power source, characteristics optimal for manned spaceflight and areas where power and computing resources are scarce.

Spaceflight Toxicology

NASA Technical Reports Server (NTRS)

Meyers, Valerie

2008-01-01

This viewgraph presentation provides a review of NASA Johnson Space Center's Toxicology program. The mission of this program is to protect crews from toxic exposures during spaceflight. The presentation reviews some of the health hazards. A toxicological hazard level chart is presented that reviews the rating of hazard level, irritancy, systemic effects and containability. The program also participates in the Lunar Airborne Dust Toxicity Advisory Group.

Genitourinary issues during spaceflight: a review.

PubMed

Jones, J A; Jennings, R; Pietryzk, R; Ciftcioglu, N; Stepaniak, P

2005-12-01

The genitourinary (GU) system is not uncommonly affected during previous spaceflights. GU issues that have been observed during spaceflight include urinary calculi, infections, retention, waste management, and reproductive. In-flight countermeasures for each of these issues are being developed to reduce the likelihood of adverse sequelae, due to GU issues during exploration-class spaceflight, to begin in 2018 with flights back to the Moon and on to Mars, according to the February 2004 Presendent's Vision for US Space Exploration. With implementation of a robust countermeasures program, GU issues should not have a significant threat for mission impact during future spaceflights.

NASA philosophy concerning space stations as operations centers for construction and maintenance of large orbiting energy systems

NASA Technical Reports Server (NTRS)

Freitag, R. F.

1976-01-01

Future United States plans for manned space-flight activities are summarized, emphasizing the long-term goals of achieving permanent occupancy and limited self-sufficiency in space. NASA-sponsored studies of earth-orbiting Space Station concepts are reviewed along with lessons learned from the Skylab missions. Descriptions are presented of the Space Transportation System, the Space Construction Base, and the concept of space industrialization (the processing and manufacturing of goods in space). Future plans for communications satellites, solar-power satellites, terrestrial observations from space stations, and manned orbital-transfer vehicles are discussed.

The case for support of manned spaceflight as a platform for research on sarcopenia and osteopenia

NASA Astrophysics Data System (ADS)

Rennie, Michael J.; Narici, Marco V.

2004-06-01

The United Kingdom government has decided to be part of the European Space Agency’s Aurora programme, but so far it has declared an intention only to participate in aspects of the programme which do not involve human space flight. Personally, we believe this to be a mistake, mainly because of the inherent limitations of robots, especially in unforeseen circumstances. However the arguments we make are different to this and are focussed mainly upon the benefits to earth based science, medicine, technology and education which would accrue from a manned space flight programme.

CHIMPANZEE HAM - POST MERCURY-REDSTONE (MR)-2 FLIGHT

NASA Image and Video Library

1963-01-01

S63-18198 (31 Jan. 1961) --- Closeup view of the chimpanzee "Ham", the live test subject for the Mercury-Redstone 2 (MR-2) test flight, following his successful recovery from the Atlantic. The 420-statute mile suborbital MR-2 flight by the 37-pound primate was a significant accomplishment on the American route toward manned spaceflight. Photo credit: NASA

Astronaut John Glenn poses for press photographers at Cape Canaveral

NASA Image and Video Library

1962-02-01

S64-14869 (February 1962) --- Astronaut John H. Glenn Jr., wearing a Mercury pressure suit, was the pilot of the Mercury-Atlas 6 (MA-6) mission. Glenn made America's first manned Earth-orbital spaceflight on Feb. 20, 1962. This photograph was taken at Cape Canaveral, Florida, during MA-6 preflight training activities. Photo credit: NASA

View of Astronaut John Glenn in his Mercury pressure suit

NASA Image and Video Library

1964-10-27

S64-36910 (February 1962) --- Astronaut John H. Glenn Jr., wearing a Mercury pressure suit, was the pilot of the Mercury-Atlas 6 (MA-6) mission. Glenn made America's first manned Earth-orbiting spaceflight on Feb. 20, 1962. This photograph was taken at Cape Canaveral, Florida, during MA-6 preflight training activities. Photo credit: NASA

In Brief: Web site for human spaceflight review committee

NASA Astrophysics Data System (ADS)

Showstack, Randy

2009-06-01

As part of an independent review of human spaceflight plans and programs, NASA has established a Web site for the Review of U.S. Human Space Flight Plans Committee (http://hsfnasagov). The Web site provides the committee's charter, relevant documents, information about meetings and members, and ways to contact the committee. “The human spaceflight program belongs to everyone. Our committee would hope to benefit from the views of all who would care to contact us,” noted committee chairman Norman Augustine, retired chair and CEO of Lockheed Martin Corporation.

NASA, Building Tomorrow's Future

NASA Technical Reports Server (NTRS)

Mango, Edward

2011-01-01

We, as NASA, continue to Dare Mighty Things. Here we are in October. In my country, the United States of America, we celebrate the anniversary of Christopher Columbus's arrival in the Americas, which occurred on October 12, 1492. His story, although happening over 500 years ago, is still very valid today. It is a part of the American spirit; part of the international human spirit. Columbus is famous for discovering the new world we now call America, but he probably never envisioned what great discoveries would be revealed many generations later. But in order for Columbus to begin his great adventure, he needed a business plan. Ho would he go about obtaining the funds and support necessary to build, supply, and man the ships required for his travels? He had a lot of obstacles and distractions. He needed a strong, internal drive to achieve his plans and recruit a willing crew of explorers also ready to risk their all for the unknown journey ahead. As Columbus set sail, he said "By prevailing over all obstacles and distractions, one may unfailingly arrive at his chosen goal or destination." Columbus may not have known he was on a journey for all human exploration. Recently, Charlie Bolden, the NASA Administrator, said, "Human exploration is and has always been about making life better for humans on Earth." Today, NASA and the U.S. human spaceflight program hold many of the same attributes as did Columbus and his contemporaries - a willing, can-do spirit. We are on the threshold of exciting new times in space exploration. Like Columbus, we need a business plan to take us into the future. We need to design the best ships and utilize the best designers, with their past knowledge and experience, to build those ships. We need funding and support from governments to achieve these goals of space exploration into the unknown. NASA does have that business plan, and it is an ambitious plan for human spaceflight and exploration. Today, we have a magnificent spaceflight laboratory, built over many years by the United States and other nations. Last month, the last man to step off the moon, Gene Cernan, told the U.S. Congress, "Today the International Space Station, the assembly of which may well go down in history as man's greatest engineering accomplishment of all time, circles the globe sixteen times every day - all in keeping with JFK's challenge to do the other things." The International Space Station (ISS) is a ship which provides an outstanding platform 'for performing spaceborne scientific, engineering, and Earth studies. Numerous nations utilize this unique cooperative partnership by sending scientists, engineers, astronauts, and cosmonauts to the ISS to spend time aboard the station in order to further scientific research, truly an asset for the entire planet.

Defending spaceflight: The echoes of Apollo

NASA Astrophysics Data System (ADS)

Rovetto, R. J.

2016-12-01

This paper defends, and emphasizes the importance of, spaceflight, broadly construed to include human and unmanned spaceflight, space science, exploration and development. Within this discourse, I provide counter-replies to remarks by physicist Dr. Steven Weinberg against my previous support of human spaceflight. In this defense of peaceful spaceflight I draw upon a variety of sources. Although a focus is human spaceflight, human and unmanned modes must not be treated as an either-or opposition. Rather, each has a critical role to play in moving humanity forward as a spacefaring species. In the course of this communication, I also stress the perennial role of space agencies as science and technology-drivers, and their function to provide a stable and unified platform for space programs.

Centrifuge-Simulated Suborbital Spaceflight in a Subject with Cardiac Malformation.

PubMed

Blue, Rebecca S; Blacher, Eric; Castleberry, Tarah L; Vanderploeg, James M

2015-11-01

Commercial spaceflight participants (SFPs) will introduce new medical challenges to the aerospace community, with unique medical conditions never before exposed to the space environment. This is a case report regarding the response of a subject with multiple cardiac malformations, including aortic insufficiency, pulmonary atresia, pulmonary valve replacement, ventricular septal defect (post-repair), and pulmonary artery stenosis (post-dilation), to centrifuge acceleration simulating suborbital flight. A 23-yr-old man with a history of multiple congenital cardiac malformations underwent seven centrifuge runs over 2 d. Day 1 consisted of two +G(z) runs (peak = +3.5 G(z), run 2) and two +G(x) runs (peak = +6.0 G(x), run 4). Day 2 consisted of three runs approximating suborbital spaceflight profiles (combined +G(x) and +G(z)). Data collected included blood pressure, electrocardiogram, pulse oximetry, neurovestibular exams, and post-run questionnaires regarding motion sickness, disorientation, greyout, and other symptoms. Despite the subject's significant medical history, he tolerated the acceleration profiles well and demonstrated no significant abnormal physiological responses. Potential risks to SFPs with aortic insufficiency, artificial heart valves, or valvular insufficiency include lower +G(z) tolerance, earlier symptom onset, and ineffective mitigation strategies such as anti-G straining maneuvers. There are no prior studies of prolonged accelerations approximating spaceflight in such individuals. This case demonstrates tolerance of acceleration profiles in an otherwise young and healthy individual with significant cardiac malformations, suggesting that such conditions may not necessarily preclude participation in commercial spaceflight.

Building a Shared Definitional Model of Long Duration Human Spaceflight

NASA Technical Reports Server (NTRS)

Orr, M.; Whitmire, A.; Sandoval, L.; Leveton, L.; Arias, D.

2011-01-01

In 1956, on the eve of human space travel Strughold first proposed a simple classification of the present and future stages of manned flight that identified key factors, risks and developmental stages for the evolutionary journey ahead. As we look to optimize the potential of the ISS as a gateway to new destinations, we need a current shared working definitional model of long duration human space flight to help guide our path. Initial search of formal and grey literature augmented by liaison with subject matter experts. Search strategy focused on both the use of term long duration mission and long duration spaceflight, and also broader related current and historical definitions and classification models of spaceflight. The related sea and air travel literature was also subsequently explored with a view to identifying analogous models or classification systems. There are multiple different definitions and classification systems for spaceflight including phase and type of mission, craft and payload and related risk management models. However the frequently used concepts of long duration mission and long duration spaceflight are infrequently operationally defined by authors, and no commonly referenced classical or gold standard definition or model of these terms emerged from the search. The categorization (Cat) system for sailing was found to be of potential analogous utility, with its focus on understanding the need for crew and craft autonomy at various levels of potential adversity and inability to gain outside support or return to a safe location, due to factors of time, distance and location.

KSC-2011-3330

NASA Image and Video Library

2011-05-05

CAPE CANAVERAL, Fla. -- More than 200 workers from the original Mercury program pose for a group photo in front of a replica of a Mercury-Redstone rocket during a celebration at Complex 5/6 on Cape Canaveral Air Force Station in Florida. The celebration was held at the launch site of the first U.S. manned spaceflight May 5, 1961, to mark the 50th anniversary of the flight. Fifty years ago, astronaut Alan Shepard lifted off inside the Mercury capsule, "Freedom 7," atop an 82-foot-tall Mercury-Redstone rocket at 9:34 a.m. EST, sending him on a remarkably successful, 15-minute suborbital flight. The event was attended by more than 200 workers from the original Mercury program and included a re-creation of Shepard's flight and recovery, as well as a tribute to his contributions as a moonwalker on the Apollo 14 lunar mission. For more information, visit www.nasa.gov/topics/history/milestones/index.html. Photo credit: NASA/Kim Shiflett

Increased nutritional quality of plants for long-duration spaceflight missions through choice of plant variety and manipulation of growth conditions

NASA Astrophysics Data System (ADS)

Cohu, Christopher M.; Lombardi, Elizabeth; Adams, William W.; Demmig-Adams, Barbara

2014-02-01

Low levels of radiation during spaceflight increase the incidence of eye damage and consumption of certain carotenoids (especially zeaxanthin), via a whole-food-based diet (rather than from supplements), is recommended to protect human vision against radiation damage. Availability of fresh leafy produce has, furthermore, been identified as desirable for morale during long spaceflight missions. We report that only trace amounts of zeaxanthin are retained post-harvest in leaves grown under conditions conducive to rapid plant growth. We show that growth of plants under cool temperatures and very high light can trigger a greater retention of zeaxanthin, while, however, simultaneously retarding plant growth. We here introduce a novel growth condition—low growth light supplemented with several short daily light pulses of higher intensity—that also triggers zeaxanthin retention, but without causing any growth retardation. Moreover, two plant varieties with different hardiness exhibited a different propensity for zeaxanthin retention. These findings demonstrate that growth light environment and plant variety can be exploited to simultaneously optimize nutritional quality (with respect to zeaxanthin and two other carotenoids important for human vision, lutein and β-carotene) as well as biomass production of leafy greens suitable as bioregenerative systems for long-duration manned spaceflight missions.

Environmental control system development for manned spacecraft 1960-1973

NASA Technical Reports Server (NTRS)

Popma, D. C.

1974-01-01

This paper provides an overview of the development of environmental revitalization techniques from their beginnings in caisson and submarine habitats, up to the present time. The use of CO2 adsorbents, such as LiOH and their application to the first U.S. manned spaceflight is described, together with the beginnings of the regenerable CO2 sorber technology using molecular sieves and its ultimate application to Skylab. The concepts and hardware systems used for atmospheric revitalization on all major U.S. ground-based manned tests is detailed, including CO2 reduction and O2 generation processes. Current research and development efforts are also outlined. The paper concludes with a detailed description of the recently completed SSP, the most advanced and complete ECS that has been fabricated to date.

Behavioral Health and Performance Operations at the NASA Johnson Space Center: A Comprehensive Program that Addresses Flight and Spaceflight Duty Adaptability

NASA Technical Reports Server (NTRS)

Beven, G. E.

2017-01-01

NASA astronauts on active status require medical certification for aircraft flying duties as well as readiness for long duration spaceflight training, launch to the International Space Station (ISS), and mission continuation during spaceflight operations. Behavioral fitness and adaptability is an inherent component of medical certification at NASA and requires a unique approach that spans the professional life-span of all active astronauts. TOPIC: This presentation will address the Behavioral Health and Performance (BHP) operations program at the Johnson Space Center. Components of BHP operations include astronaut selection, as well as annual, elective, preflight, inflight, and postflight BHP assessments. Each aspect of the BHP operations program will be discussed, with a focus on behavioral fitness determination and resultant outcomes. Specifically, astronaut selection generates a rating of suitability for long duration spaceflight as well as psychiatric qualification; annual, preflight and postflight BHP assessments provoke a decision regarding the presence of any aeromedical concerns; and inflight assessment requires a conclusion pertaining to mission impact. The combination of these elements provide for a unique, comprehensive approach to flight and spaceflight adaptability. APPLICATIONS: Attendees will understand the differing facets of NASA's comprehensive BHP operations program that occurs over the course of an astronaut's career and be able to compare and contrast this to the Adaptability Rating for Military Aviation (ARMA) and proposed models presented by others on this panel.

Recovery - Mercury-Redstone (MR)-2 - Loaded on Ship - Chimp "Ham"

NASA Image and Video Library

1961-01-31

S61-00199 (31 Jan. 1961) --- Recovery personnel aboard the USS Donner remove ?Ham?, a 37-pound chimpanzee, from a Mercury-Redstone spacecraft following the successful Mercury-Redstone 2 (MR-2) suborbital flight from Cape Canaveral, Florida. The primate's 420-statute mile MR-2 flight was a significant accomplishment on the American route toward manned spaceflight. Photo credit: NASA

Examination - Plants - Lunar (Germ Free) Soil - Plant Laboratory - MSC

NASA Image and Video Library

1969-10-08

S69-53894 (October 1969) --- Dr. Charles H. Walkinshaw, Jr., Spaceflight Biotechnology Branch botanist, Preventive Medicine Division, Manned Spacecraft Center (MSC), examines sorghum and tobacco plants in lunar (germ free) soil in the Plant Laboratory of the MSC’s Lunar Receiving Laboratory. The soil was brought back from the moon by the crew of the Apollo 11 lunar landing mission.

Gemini 4 prime crew with Official medical nurse for Astronaut crew members

NASA Technical Reports Server (NTRS)

1965-01-01

Gemini 4 prime crew, Astronauts Edward H. White II, (left), and James A. McDivitt (right) are shown with Lt. Dolores (Dee) O'Hare, US Air Force, Center Medical Office, Flight Medicine Branch, Manned Spaceflight Center (MSC). Lieutenant O'Hare has served during several space flights as Official medical nurse for the astronaut crew members on the missions.

Astronaut John Young hoisted aboard helicopter during water egress training

NASA Image and Video Library

1966-06-18

S66-39713 (18 June 1966) --- Astronaut John W. Young, Gemini-10 command pilot, is hoisted up to a U.S. Coast Guard helicopter during water egress training in the Gulf of Mexico. A team of Manned Spaceflight Center (MSC) swimmers assists in the exercise. The Static Article 5 spacecraft can be seen in the water. Photo credit: NASA

SHOWN WITH NURSE - ASTRONAUT EDWARD H. WHITE II - MISC. - CAPE

NASA Image and Video Library

1965-06-01

S65-29657 (June 1965) --- Gemini-4 prime crew, astronauts Edward H. White II (left), and James A. McDivitt are shown with Lt. Dolores (Dee) O'Hare, US Air Force, Center Medical Office, Flight Medicine Branch, Manned Spacecraft Center (MSC). Lieutenant O'Hare has served during several spaceflights as official medical nurse for the astronaut crew members on the missions.

Atmosphere Resource Recovery and Environmental Monitoring Trace Contaminant Control Through FY 2012

NASA Technical Reports Server (NTRS)

Perry, J. L.; Pruitt, M. W.; Wheeler, R. M.; Monje, O.

2013-01-01

Trace contaminant control has been a concern of spacecraft designers and operators from early in the progression of manned spaceflight. Significant technological advancement has occurred since the first designs were implemented in the 1960s, culminating in the trace contaminant control system currently in use aboard the International Space Station as part of the atmosphere revitalization system.

Validation of NHB 8060.1C, Test 18 Arc Tracking, September 30, 1991

NASA Technical Reports Server (NTRS)

Linley, Larry

2005-01-01

A test project was conducted to validate Test 18 of NASA Handbook (NHB) 8060.1C and, if necessary, identify and recommend improvements in the procedures or criteria of the test. The NHB 8060.1C, Test 18 test system was modified to produce better discrimination of test results. Changes, and their effects on test results, in the graphite immersion-depth, test timing sequence, and atmospheric conditions were investigated for the wire-insulation constructions tested. Based on the test results, the graphite immersion-depths (between 0.8 mm and 1.6 mm), the timing sequence, and the change in the test conditions from ambient to three environments common in manned spaceflight did not significantly affect test results. The criteria used in Test 18 of NHB 8060.1C was found to be appropriate for qualifying arc-tracking and arc-propagation characteristics of wire-insulation materials, Using the Test 18 criteria, Kapton and ETFE were considered inappropriate for use, while PTFE was considered appropriate. Recommendations from this test project for Test 18 of NHB 8060.1C include changing the experimental setup and configurational tests and performing qualification testing in air rather than in the three environments common in manned spaceflight.

Pure Water From a Pure Genius

NASA Technical Reports Server (NTRS)

2002-01-01

Ammonium perchlorate is widely used throughout the aerospace, munitions, and pyrotechnics industries as a primary ingredient in solid rocket and missile propellants, fireworks, and explosive charges. This highly soluble salt has tainted soils and water sources all over the world, and is believed to be an endocrine disrupter, adversely affecting the growth patterns of a fetus or a young child. UMPQUA Research Company (URC), once a small drinking water testing laboratory and a research and development contractor for NASA's manned spaceflight applications, has evolved to become a leader in water purification and analysis. With a total of 11 patents issued for new technologies created by URC under NASA SBIR contracts and a 25-year commitment to water recycling, the company clearly possessed the qualifications necessary to tackle the presence of perchlorate in water. An SBIR contract with NASA's Marshall Space Flight Center that concentrated on the stringent water quality requirements of long-term, manned spaceflight was the source for URC's process and catalyst to facilitate the destruction of perchlorate and nitrate in water. URC licensed the rights of its unique reduction reaction process to Calgon Carbon Corporation for use with the company's perchlorate/nitrate remediation process, otherwise known as ISEP(R).

KSC-2011-3332

NASA Image and Video Library

2011-05-05

CAPE CANAVERAL, Fla. -- Invited guests attending a celebration at Complex 5/6 on Cape Canaveral Air Force Station in Florida tour the blockhouse. The celebration was held at the launch site of the first U.S. manned spaceflight May 5, 1961, to mark the 50th anniversary of the flight. Fifty years ago, astronaut Alan Shepard lifted off inside the Mercury capsule, "Freedom 7," atop an 82-foot-tall Mercury-Redstone rocket at 9:34 a.m. EST, sending him on a remarkably successful, 15-minute suborbital flight. The event was attended by more than 200 workers from the original Mercury program and included a re-creation of Shepard's flight and recovery, as well as a tribute to his contributions as a moonwalker on the Apollo 14 lunar mission. For more information, visit www.nasa.gov/topics/history/milestones/index.html. Photo credit: NASA/Kim Shiflett

KSC-2011-3322

NASA Image and Video Library

2011-05-05

CAPE CANAVERAL, Fla. -- Invited guests and media representatives attend a celebration at Complex 5/6 on Cape Canaveral Air Force Station in Florida. The celebration was held at the launch site of the first U.S. manned spaceflight May 5, 1961, to mark the 50th anniversary of the flight. Fifty years ago, astronaut Alan Shepard lifted off inside the Mercury capsule, "Freedom 7," atop an 82-foot-tall Mercury-Redstone rocket at 9:34 a.m. EST, sending him on a remarkably successful, 15-minute suborbital flight. The event was attended by more than 200 workers from the original Mercury program and included a re-creation of Shepard's flight and recovery, as well as a tribute to his contributions as a moonwalker on the Apollo 14 lunar mission. For more information, visit www.nasa.gov/topics/history/milestones/index.html. Photo credit: NASA/Kim Shiflett

KSC-2011-3314

NASA Image and Video Library

2011-05-05

CAPE CANAVERAL, Fla. -- Mercury astronaut Scott Carpenter participates in a celebration at Complex 5/6 on Cape Canaveral Air Force Station in Florida. The celebration was held at the launch site of the first U.S. manned spaceflight May 5, 1961, to mark the 50th anniversary of the flight. Fifty years ago, astronaut Alan Shepard lifted off inside the Mercury capsule, "Freedom 7," atop an 82-foot-tall Mercury-Redstone rocket at 9:34 a.m. EST, sending him on a remarkably successful, 15-minute suborbital flight. The event was attended by more than 200 workers from the original Mercury program and included a re-creation of Shepard's flight and recovery, as well as a tribute to his contributions as a moonwalker on the Apollo 14 lunar mission. For more information, visit www.nasa.gov/topics/history/milestones/index.html. Photo credit: NASA/Kim Shiflett

KSC-2011-3316

NASA Image and Video Library

2011-05-05

CAPE CANAVERAL, Fla. -- Invited guests attend a celebration at Complex 5/6 on Cape Canaveral Air Force Station in Florida. The celebration was held at the launch site of the first U.S. manned spaceflight May 5, 1961, to mark the 50th anniversary of the flight. Fifty years ago, astronaut Alan Shepard lifted off inside the Mercury capsule, "Freedom 7," atop an 82-foot-tall Mercury-Redstone rocket at 9:34 a.m. EST, sending him on a remarkably successful, 15-minute suborbital flight. The event was attended by more than 200 workers from the original Mercury program and included a re-creation of Shepard's flight and recovery, as well as a tribute to his contributions as a moonwalker on the Apollo 14 lunar mission. For more information, visit www.nasa.gov/topics/history/milestones/index.html. Photo credit: NASA/Kim Shiflett

KSC-2011-3328

NASA Image and Video Library

2011-05-05

CAPE CANAVERAL, Fla. -- NASA Administrator Charlie Bolden addresses the audience during a celebration at Complex 5/6 on Cape Canaveral Air Force Station in Florida. The celebration was held at the launch site of the first U.S. manned spaceflight May 5, 1961, to mark the 50th anniversary of the flight. Fifty years ago, astronaut Alan Shepard lifted off inside the Mercury capsule, "Freedom 7," atop an 82-foot-tall Mercury-Redstone rocket at 9:34 a.m. EST, sending him on a remarkably successful, 15-minute suborbital flight. The event was attended by more than 200 workers from the original Mercury program and included a re-creation of Shepard's flight and recovery, as well as a tribute to his contributions as a moonwalker on the Apollo 14 lunar mission. For more information, visit www.nasa.gov/topics/history/milestones/index.html. Photo credit: NASA/Kim Shiflett

KSC-2011-3320

NASA Image and Video Library

2011-05-05

CAPE CANAVERAL, Fla. -- Invited guests of all ages attend a celebration at Complex 5/6 on Cape Canaveral Air Force Station in Florida. The celebration was held at the launch site of the first U.S. manned spaceflight May 5, 1961, to mark the 50th anniversary of the flight. Fifty years ago, astronaut Alan Shepard lifted off inside the Mercury capsule, "Freedom 7," atop an 82-foot-tall Mercury-Redstone rocket at 9:34 a.m. EST, sending him on a remarkably successful, 15-minute suborbital flight. The event was attended by more than 200 workers from the original Mercury program and included a re-creation of Shepard's flight and recovery, as well as a tribute to his contributions as a moonwalker on the Apollo 14 lunar mission. For more information, visit www.nasa.gov/topics/history/milestones/index.html. Photo credit: NASA/Kim Shiflett

Group dynamics training for manned spaceflight and the capsuls mission: Prophylactic against incompatibility and its consequences?

NASA Astrophysics Data System (ADS)

Kass, R.; Kass, J.

On February 7, 1994, four Canadian Astronauts were sealed off in a hyperbaric chamber at the Canadian Government's Defense and Civil Institute for Environmental Medicine in Toronto, Canada. This space lab training mission lasted seven days and was the first to be conducted with astronauts outside of Russia. The objective of this mission was to give Canadian astronauts, space scientists and the staff of the Canadian Space Agency (CSA), the opportunity to gain first hand experience on preparational and operational aspects of a typical space mission. Twenty-one scientific experiments involving six countries from several disciplines were involved in this mission. This paper describes the goals and preliminary results of a psychological experiment/training program that used the CAPSULS mission as a test bed for its application in the manned space flight environment. The objective of this project was to enhance the understanding of small group behaviour with a view to maximizing team effectiveness and task accomplishment in teams living and working in isolation under difficult and confined conditions. The application of this model in the light of future missions is a key thesis in this paper.

Earth Observations

NASA Image and Video Library

2010-07-31

ISS024-E-010403 (31 July 2010) --- This detailed image ? photographed by an Expedition 24 crew member on the International Space Station (ISS) ? is centered on the NASA Lyndon B. Johnson Space Center (JSC), located in the southeastern Houston, TX metropolitan area. While initially being represented by a number of temporary locations in Houston, the facility was established in 1961 as the Manned Spacecraft Center and renamed in honor of the late U.S. President Johnson (a Texas native) in 1973. JSC serves as the lead NASA center for both astronaut training and mission control of manned spacecraft - such as the ISS and space shuttle - and has done so throughout the history of the U.S. manned space program. The Center also collaborates with other NASA and international partner facilities in a variety of scientific and engineering programs related to human spaceflight and planetary exploration. JSC is located approximately midway between downtown Houston and Galveston, TX, and is bordered by several smaller municipalities that form a mosaic of urban and suburban land use (grey areas with street grids, and commercial/industrial areas characterized by white rooftops). Large tracts of grassy fields and forests in the area (light to dark green respectively) include nature preserves, grazing lands, and flood control areas. Also visible at upper left is Ellington Field. This airport services a variety of NASA aircraft used for astronaut training, scientific, and cargo transport purposes. Clear Lake, an inlet of Galveston Bay, is located to the immediate southeast of JSC. Both Clear Lake and Galveston Bay appear silver-grey due to sunglint, or light reflected back towards the observer on the ISS that gives the water surface a mirror-like appearance. Several boat wakes are visible in Galveston Bay (right) due to disruption of the water surface that reduces the sunglint effect.

Preliminary Design Considerations for Access and Operations in Earth-Moon L1/L2 Orbits

NASA Technical Reports Server (NTRS)

Folta, David C.; Pavlak, Thomas A.; Haapala, Amanda F.; Howell, Kathleen C.

2013-01-01

Within the context of manned spaceflight activities, Earth-Moon libration point orbits could support lunar surface operations and serve as staging areas for future missions to near-Earth asteroids and Mars. This investigation examines preliminary design considerations including Earth-Moon L1/L2 libration point orbit selection, transfers, and stationkeeping costs associated with maintaining a spacecraft in the vicinity of L1 or L2 for a specified duration. Existing tools in multi-body trajectory design, dynamical systems theory, and orbit maintenance are leveraged in this analysis to explore end-to-end concepts for manned missions to Earth-Moon libration points.

Extravehicular activities guidelines and design criteria

NASA Technical Reports Server (NTRS)

Brown, N. E.; Dashner, T. R.; Hayes, B. C.

1973-01-01

A listing of astronaut EVA support systems and equipment, and the physical, operational, and performance characteristics of each major system are presented. An overview of the major ground based support operations necessary in the development and verification of orbital EVA systems is included. The performance and biomedical characteristics of man in the orbital EV environment are discussed. Major factors affecting astronaut EV work performance are identified and delineated as they relate to EV support systems design. Data concerning the medical and physiological aspects of spaceflight on man are included. The document concludes with an extensive bibliography, and a series of appendices which expand on some of the information presented in the main body.

Summary of Liquid Propulsion System Needs in Support of the Constellation Program

NASA Technical Reports Server (NTRS)

Lorier, Terry; Sumrall, Phil; Baine, Michael

2008-01-01

In January 2004, the President of the United States established the Vision for Space Exploration (VSE) to complete the International Space Station, retire the Space Shuttle and develop its replacement, and expand the human presence on the Moon as a stepping stone to human exploration of Mars and worlds beyond. In response, NASA developed the Constellation Program, consisting of the components shown in Figure 1. This paper will summarize the manned spaceflight liquid propulsion system needs in support of the Constellation Program over the next 10 years. It will address all liquid engine needs to support human exploration from low Earth orbit (LEO) to the lunar surface, including an overview of engines currently under contract, those baselined but not yet under contract, and those propulsion needs that have yet to be initiated. There may be additional engine needs for early demonstrators, but those will not be addressed as part of this paper. Also, other portions of the VSE architecture, including the planned Orion abort test boosters and the Lunar Precursor Robotic Program, are not addressed here as they either use solid motors or are focused on unmanned elements of returning humans to the Moon.

Minimal support technology and in situ resource utilization for risk management of planetary spaceflight missions

NASA Astrophysics Data System (ADS)

Murphy, K. L.; Rygalov, V. Ye.; Johnson, S. B.

2009-04-01

All artificial systems and components in space degrade at higher rates than on Earth, depending in part on environmental conditions, design approach, assembly technologies, and the materials used. This degradation involves not only the hardware and software systems but the humans that interact with those systems. All technological functions and systems can be expressed through functional dependence: [Function]˜[ERU]∗[RUIS]∗[ISR]/[DR];where [ERU]efficiency (rate) of environmental resource utilization[RUIS]resource utilization infrastructure[ISR]in situ resources[DR]degradation rateThe limited resources of spaceflight and open space for autonomous missions require a high reliability (maximum possible, approaching 100%) for system functioning and operation, and must minimize the rate of any system degradation. To date, only a continuous human presence with a system in the spaceflight environment can absolutely mitigate those degradations. This mitigation is based on environmental amelioration for both the technology systems, as repair of data and spare parts, and the humans, as exercise and psychological support. Such maintenance now requires huge infrastructures, including research and development complexes and management agencies, which currently cannot move beyond the Earth. When considering what is required to move manned spaceflight from near Earth stations to remote locations such as Mars, what are the minimal technologies and infrastructures necessary for autonomous restoration of a degrading system in space? In all of the known system factors of a mission to Mars that reduce the mass load, increase the reliability, and reduce the mission’s overall risk, the current common denominator is the use of undeveloped or untested technologies. None of the technologies required to significantly reduce the risk for critical systems are currently available at acceptable readiness levels. Long term interplanetary missions require that space programs produce a craft with all systems integrated so that they are of the highest reliability. Right now, with current technologies, we cannot guarantee this reliability for a crew of six for 1000 days to Mars and back. Investigation of the technologies to answer this need and a focus of resources and research on their advancement would significantly improve chances for a safe and successful mission.

Selection of human consumables for future space missions

NASA Technical Reports Server (NTRS)

Bourland, C. T.; Smith, M. C.

1991-01-01

Consumables for human spaceflight include oxygen, water, food and food packaging, personal hygiene items, and clothing. This paper deals with the requirements for food and water, and their impact on waste product generation. Just as urbanization of society has been made possible by improved food processing and packaging, manned spaceflight has benefitted from this technology. The downside of this technology is increased food package waste product. Since consumables make up a major portion of the vehicle onboard stowage and generate most of the waste products, selection of consumables is a very critical process. Food and package waste comprise the majority of the trash generated on the current shuttle orbiter missions. Plans for future missions must include accurate assessment of the waste products to be generated, and the methods for processing and disposing of these wastes.

Biological filters and their use in potable water filtration systems in spaceflight conditions

NASA Astrophysics Data System (ADS)

Thornhill, Starla G.; Kumar, Manish

2018-05-01

Providing drinking water to space missions such as the International Space Station (ISS) is a costly requirement for human habitation. To limit the costs of water transport, wastewater is collected and purified using a variety of physical and chemical means. To date, sand-based biofilters have been designed to function against gravity, and biofilms have been shown to form in microgravity conditions. Development of a universal silver-recycling biological filter system that is able to function in both microgravity and full gravity conditions would reduce the costs incurred in removing organic contaminants from wastewater by limiting the energy and chemical inputs required. This paper aims to propose the use of a sand-substrate biofilter to replace chemical means of water purification on manned spaceflights.

Cardiovascular adaptation to spaceflight

NASA Technical Reports Server (NTRS)

Charles, John B.; Lathers, Claire M.

1991-01-01

Data are presented on the rate of adaptation of the human cardiovascular system to conditions of spaceflight, with particular attention given to data obtained during spaceflight in the U.S. Space Shuttle Program. It is pointed out that many of the cardiovascular changes that occurred during spaceflights that lasted from 2 to 11 days can be traced directly to changes in the body fluid volume. The beneficial effects of a fluid loading countermeasure (oral rehydration) and of the supine body position on the heart rate during the spaceflight are demonstrated. It is noted that, after hours or a few days of spaceflight, a state of adaptation is reached, in which the subject is well adapted and appropriately hydrated for the weightless environment. However, the return to the normal gravity of the earth leaves the individual especially sensitive to orthostatic stress.

The Development of Fuel Cell Technology for NASA's Human Spaceflight Program

NASA Technical Reports Server (NTRS)

Scott, John H.

2007-01-01

My task this morning is to review the history and current direction of fuel cell technology development for NASA's human spaceflight program and to compare it to the directions being taken in that field for The Hydrogen Economy. The concept of "The Hydrogen Economy" involves many applications for fuel cells, but for today's discussion, I'll focus on automobiles.

Effects of high-orbit spaceflight on signaling cascades and apoptosis in immune cells from mice flied on board the BION-M1 satellite

NASA Astrophysics Data System (ADS)

Novoselova, Elena; Shenkman, Boris; Lunin, Sergey; Parfenyuk, Svetlana; Novoselova, Tatyana; Fesenko, Eugeny

The study was designed to evaluate immune cell activity in male C57bl mice after a 30-day high-orbit spaceflight (550 km, higher than conventional manned spaceflights) on board the BION-M1 satellite (Roskosmos Program, Russia). For the present study, thymus, spleens and plasma samples were collected from mice 12 h after landing and, additionally, 7 days subsequently. Assessing the activity of NF-kappaB signaling cascade by measuring Rel A (p65) protein phosphorylation in splenic lymphocytes, we showed that the NF-kappaB activity was significantly increased at 12 h after landing. Contrariwise, one week after landing, the NF-kappaB activity was markedly decreased, even below to the control values. Interestingly, after landing there were no significant changes in SAPK/JNK cascade activity in splenic lymphocytes as well as in the expression of transcription factor IRF3 in thymus cells. To assess the apoptosis status in thymus lymphocytes, levels of p53 protein and its phosphorylated form were measured in thymic lymphocytes. It is known that p53 plays an important role in the cellular response to DNA damage, genomic aberrations, and other characteristic of apoptosis. The results showed that the high-orbit spaceflight environment caused some increase in level of p53 protein, but most notably, activated phosphorylated form of p53 protein. Calculated ratio of active and inactive forms of the protein (ph-p53/p53) 12 h after landing increased by more than 2-fold, indicating the apparent induction of apoptosis in thymus cells. Interestingly, 7 days after the landing, this ratio was not restored, but rather increased: the specified ratio was 4 times higher as compared to the ground-based control. We can conclude that response to the prolonged high-orbit spaceflight is not like the classic "stress response", which is usually observed under various stressful factors. It is known that the stress response is surely accompanied by increased SAPK/JNK cascade activity as well as the expression of the IRF3; in fact, we did not observed any changes in the SAPK/JNK phosphorylation or in the IRF3 production. Furthermore, stressful factors usually result in the fast, but reversible, thymus involution. But our measurements showed that the thymus depletion at 7th day after landing was expressed even more than 12 h after the spaceflight. This is consistent with the results of the level of apoptosis in thymus cells; indeed, the apoptosis in thymus lymphocytes 7 days after was higher than 12 h after landing. Collectively, these results indicate that the changes of immune cell homeostasis may be a result of exposure to damaging factors of not very high intensity. In any case, similar effects are caused, to our knowledge, by low doses of ionizing radiation. As spaceflight is not accompanied only with the gravitational changes, but also with other factors, such as radiation, it is possible that immune disbalance after spaceflight was caused by a combined action of several factors. The work was supported by the Russian Foundation for Basic Research, project 12-04-00113-a.The authors express their gratitude to unified team involved in preparation and implementation of the spaceflight of BION-M #1.

Medical policy development for human spaceflight at NASA: an evolution.

PubMed

Doarn, Charles R

2011-11-01

Codification of medical policy for the National Aeronautics and Space Administration (NASA) did not occur until 1977. Policy development was based on NASA's human spaceflight efforts from 1958, and the need to support the operational aspects of the upcoming Space Shuttle Program as well as other future activities. In 1958, the Space Task Group (STG), a part of the National Advisory Committee on Aeronautics (NACA), became the focal point for astronaut selection, medical support, and instrumentation development in support of Project Mercury. NACA transitioned into NASA in 1958. The STG moved to Houston, TX, in 1961 and became the Manned Spacecraft Center. During these early years, medical support for astronaut selection and healthcare was provided through arrangements with the U.S. military, specifically the United States Air Force, which had the largest group of subject matter experts in aerospace medicine. Through most of the 1960s, the military worked very closely with NASA in developing the foundations of bioastronautics and space medicine. This work was complemented by select individuals from outside the government. From 1958 to 1977, there was no standard approach to medical policy formulation within NASA. During this time, it was individualized and subjected to political pressures. This manuscript documents the evolution of medical policy in the NASA, and provides a historical account of the individuals, processes, and needs to develop policy.

The past, present, and future of National Aeronautics and Space Administration spaceflight diet in support of microgravity rodent experiments.

PubMed

Sun, Gwo-Shing; Tou, Janet C; Yu, Diane; Girten, Beverly E; Cohen, Jacob

2014-02-01

Rodents have been the most frequently flown animal model used to study physiological responses to the space environment. In support of future of space exploration, the National Aeronautics and Space Administration (NASA) envisions an animal research program focused on rodents. Therefore, the development of a rodent diet that is suitable for the spaceflight environment including long duration spaceflight is a high priority. Recognizing the importance of nutrition in affecting spaceflight physiological responses and ensuring reliable biomedical and biological science return, NASA developed the nutrient-upgraded rodent food bar (NuRFB) as a standard diet for rodent spaceflight. Depending on future animal habitat hardware and planned spaceflight experiments, modification of the NuRFB or development of a new diet formulation may be needed, particularly for long term spaceflights. Research in this area consists primarily of internal technical reports that are not readily accessible. Therefore, the aims of this contribution are to provide a brief history of the development of rodent spaceflight diets, to review the present diet used in rodent spaceflight studies, and to discuss some of the challenges and potential solutions for diets to be used in future long-term rodent spaceflight studies. Copyright © 2014 Elsevier Inc. All rights reserved.

Operational Philosophy Concerning Manned Spacecraft Cabin Leaks

NASA Technical Reports Server (NTRS)

DeSimpelaere, Edward

2011-01-01

The last thirty years have seen the Space Shuttle as the prime United States spacecraft for manned spaceflight missions. Many lessons have been learned about spacecraft design and operation throughout these years. Over the next few decades, a large increase of manned spaceflight in the commercial sector is expected. This will result in the exposure of commercial crews and passengers to many of the same risks crews of the Space Shuttle have encountered. One of the more dire situations that can be encountered is the loss of pressure in the habitable volume of the spacecraft during on orbit operations. This is referred to as a cabin leak. This paper seeks to establish a general cabin leak response philosophy with the intent of educating future spacecraft designers and operators. After establishing a relative definition for a cabin leak, the paper covers general descriptions of detection equipment, detection methods, and general operational methods for management of a cabin leak. Subsequently, all these items are addressed from the perspective of the Space Shuttle Program, as this will be of the most value to future spacecraft due to similar operating profiles. Emphasis here is placed upon why and how these methods and philosophies have evolved to meet the Space Shuttle s needs. This includes the core ideas of: considerations of maintaining higher cabin pressures vs. lower cabin pressures, the pros and cons of a system designed to feed the leak with gas from pressurized tanks vs. using pressure suits to protect against lower cabin pressures, timeline and consumables constraints, re-entry considerations with leaks of unknown origin, and the impact the International Space Station (ISS) has had to the standard Space Shuttle cabin leak response philosophy. This last item in itself includes: procedural management differences, hardware considerations, additional capabilities due to the presence of the ISS and its resource, and ISS docking/undocking considerations with a cabin leak occurring. The paper also offers a look at how different equipment configurations on future spacecraft impact the previously defined cabin leak operational philosophy and includes additional operational methods and considerations that result due to various configurations. The intent is to showcase these various considerations and highlight the variability they allow. The paper concludes with a selection of the author s personal observations from a spacecraft operator's point of view and recommendations with the goal of improving the design and operations of future spacecraft.

KSC-2011-3323

NASA Image and Video Library

2011-05-05

CAPE CANAVERAL, Fla. -- Lieutenant General Susan J. Helms, commander of the 14th Air Force and former astronaut, addresses the audience at a celebration at Complex 5/6 on Cape Canaveral Air Force Station in Florida. The celebration was held at the launch site of the first U.S. manned spaceflight May 5, 1961, to mark the 50th anniversary of the flight. Fifty years ago, astronaut Alan Shepard lifted off inside the Mercury capsule, "Freedom 7," atop an 82-foot-tall Mercury-Redstone rocket at 9:34 a.m. EST, sending him on a remarkably successful, 15-minute suborbital flight. The event was attended by more than 200 workers from the original Mercury program and included a re-creation of Shepard's flight and recovery, as well as a tribute to his contributions as a moonwalker on the Apollo 14 lunar mission. For more information, visit www.nasa.gov/topics/history/milestones/index.html. Photo credit: NASA/Kim Shiflett

KSC-2011-3315

NASA Image and Video Library

2011-05-05

CAPE CANAVERAL, Fla. -- Kennedy Space Center Director and former astronaut Bob Cabana addresses the audience at a celebration at Complex 5/6 on Cape Canaveral Air Force Station in Florida. The celebration was held at the launch site of the first U.S. manned spaceflight May 5, 1961, to mark the 50th anniversary of the flight. Fifty years ago, astronaut Alan Shepard lifted off inside the Mercury capsule, "Freedom 7," atop an 82-foot-tall Mercury-Redstone rocket at 9:34 a.m. EST, sending him on a remarkably successful, 15-minute suborbital flight. The event was attended by more than 200 workers from the original Mercury program and included a re-creation of Shepard's flight and recovery, as well as a tribute to his contributions as a moonwalker on the Apollo 14 lunar mission. For more information, visit www.nasa.gov/topics/history/milestones/index.html. Photo credit: NASA/Kim Shiflett

KSC-2011-3331

NASA Image and Video Library

2011-05-05

CAPE CANAVERAL, Fla. -- During a celebration at Complex 5/6 on Cape Canaveral Air Force Station in Florida, Mercury astronaut Scott Carpenter greets Calvin Fowler, the launch conductor for Carpenter's Mercury-Atlas 7 mission on May 24, 1962. The celebration was held at the launch site of the first U.S. manned spaceflight May 5, 1961, to mark the 50th anniversary of the flight. Fifty years ago, astronaut Alan Shepard lifted off inside the Mercury capsule, "Freedom 7," atop an 82-foot-tall Mercury-Redstone rocket at 9:34 a.m. EST, sending him on a remarkably successful, 15-minute suborbital flight. The event was attended by more than 200 workers from the original Mercury program and included a re-creation of Shepard's flight and recovery, as well as a tribute to his contributions as a moonwalker on the Apollo 14 lunar mission. For more information, visit www.nasa.gov/topics/history/milestones/index.html. Photo credit: NASA/Kim Shiflett

KSC-2011-3324

NASA Image and Video Library

2011-05-05

CAPE CANAVERAL, Fla. -- Kennedy Space Center Director and former astronaut Bob Cabana addresses the audience at a celebration at Complex 5/6 on Cape Canaveral Air Force Station in Florida. The celebration was held at the launch site of the first U.S. manned spaceflight May 5, 1961, to mark the 50th anniversary of the flight. Fifty years ago, astronaut Alan Shepard lifted off inside the Mercury capsule, "Freedom 7," atop an 82-foot-tall Mercury-Redstone rocket at 9:34 a.m. EST, sending him on a remarkably successful, 15-minute suborbital flight. The event was attended by more than 200 workers from the original Mercury program and included a re-creation of Shepard's flight and recovery, as well as a tribute to his contributions as a moonwalker on the Apollo 14 lunar mission. For more information, visit www.nasa.gov/topics/history/milestones/index.html. Photo credit: NASA/Kim Shiflett

KSC-2011-3327

NASA Image and Video Library

2011-05-05

CAPE CANAVERAL, Fla. -- Invited guests enjoy a tribute to astronaut Alan Shepard during a celebration at Complex 5/6 on Cape Canaveral Air Force Station in Florida. The celebration was held at the launch site of the first U.S. manned spaceflight May 5, 1961, to mark the 50th anniversary of the flight. Fifty years ago, astronaut Alan Shepard lifted off inside the Mercury capsule, "Freedom 7," atop an 82-foot-tall Mercury-Redstone rocket at 9:34 a.m. EST, sending him on a remarkably successful, 15-minute suborbital flight. The event was attended by more than 200 workers from the original Mercury program and included a re-creation of Shepard's flight and recovery, as well as a tribute to his contributions as a moonwalker on the Apollo 14 lunar mission. For more information, visit www.nasa.gov/topics/history/milestones/index.html. Photo credit: NASA/Kim Shiflett

KSC-2011-3334

NASA Image and Video Library

2011-05-05

CAPE CANAVERAL, Fla. -- Bob Moser, former chief test conductor for the Mercury-Redstone launches, tours the blockhouse at Complex 5/6 on Cape Canaveral Air Force Station in Florida. The celebration was held at the launch site of the first U.S. manned spaceflight May 5, 1961, to mark the 50th anniversary of the flight. Fifty years ago, astronaut Alan Shepard lifted off inside the Mercury capsule, "Freedom 7," atop an 82-foot-tall Mercury-Redstone rocket at 9:34 a.m. EST, sending him on a remarkably successful, 15-minute suborbital flight. The event was attended by more than 200 workers from the original Mercury program and included a re-creation of Shepard's flight and recovery, as well as a tribute to his contributions as a moonwalker on the Apollo 14 lunar mission. For more information, visit www.nasa.gov/topics/history/milestones/index.html. Photo credit: NASA/Kim Shiflett

KSC-2011-3321

NASA Image and Video Library

2011-05-05

CAPE CANAVERAL, Fla. -- The U.S. flag waves proudly in front of a replica of a Mercury-Redstone rocket at Complex 5/6 on Cape Canaveral Air Force Station in Florida. A celebration was held at the launch site of the first U.S. manned spaceflight May 5, 1961, to mark the 50th anniversary of the flight. Fifty years ago, astronaut Alan Shepard lifted off inside the Mercury capsule, "Freedom 7," atop an 82-foot-tall Mercury-Redstone rocket at 9:34 a.m. EST, sending him on a remarkably successful, 15-minute suborbital flight. The event was attended by more than 200 workers from the original Mercury program and included a re-creation of Shepard's flight and recovery, as well as a tribute to his contributions as a moonwalker on the Apollo 14 lunar mission. For more information, visit www.nasa.gov/topics/history/milestones/index.html. Photo credit: NASA/Kim Shiflett

KSC-2011-3325

NASA Image and Video Library

2011-05-05

CAPE CANAVERAL, Fla. -- NBC reporter Jay Barbree introduces Alice Wackermann, Julie Jenkins and Laura Churchley, daughters of astronaut Alan Shepard, to the audience at a celebration at Complex 5/6 on Cape Canaveral Air Force Station in Florida. The celebration was held at the launch site of the first U.S. manned spaceflight May 5, 1961, to mark the 50th anniversary of the flight. Fifty years ago, astronaut Alan Shepard lifted off inside the Mercury capsule, "Freedom 7," atop an 82-foot-tall Mercury-Redstone rocket at 9:34 a.m. EST, sending him on a remarkably successful, 15-minute suborbital flight. The event was attended by more than 200 workers from the original Mercury program and included a re-creation of Shepard's flight and recovery, as well as a tribute to his contributions as a moonwalker on the Apollo 14 lunar mission. For more information, visit www.nasa.gov/topics/history/milestones/index.html. Photo credit: NASA/Kim Shiflett

KSC-2011-3318

NASA Image and Video Library

2011-05-05

CAPE CANAVERAL, Fla. -- From left, NBC reporter Jay Barbree and Alice Wackermann, Julie Jenkins (at microphone) and Laura Churchley, daughters of astronaut Alan Shepard, participate in a celebration at Complex 5/6 on Cape Canaveral Air Force Station in Florida. The celebration was held at the launch site of the first U.S. manned spaceflight May 5, 1961, to mark the 50th anniversary of the flight. Fifty years ago, astronaut Alan Shepard lifted off inside the Mercury capsule, "Freedom 7," atop an 82-foot-tall Mercury-Redstone rocket at 9:34 a.m. EST, sending him on a remarkably successful, 15-minute suborbital flight. The event was attended by more than 200 workers from the original Mercury program and included a re-creation of Shepard's flight and recovery, as well as a tribute to his contributions as a moonwalker on the Apollo 14 lunar mission. For more information, visit www.nasa.gov/topics/history/milestones/index.html. Photo credit: NASA/Kim Shiflett

KSC-2011-3319

NASA Image and Video Library

2011-05-05

CAPE CANAVERAL, Fla. -- From left, Mercury astronaut Scott Carpenter and Alice Wackermann and Julie Jenkins, daughters of astronaut Alan Shepard, enjoy a tribute to Shepard during a celebration at Complex 5/6 on Cape Canaveral Air Force Station in Florida. The celebration was held at the launch site of the first U.S. manned spaceflight May 5, 1961, to mark the 50th anniversary of the flight. Fifty years ago, astronaut Alan Shepard lifted off inside the Mercury capsule, "Freedom 7," atop an 82-foot-tall Mercury-Redstone rocket at 9:34 a.m. EST, sending him on a remarkably successful, 15-minute suborbital flight. The event was attended by more than 200 workers from the original Mercury program and included a re-creation of Shepard's flight and recovery, as well as a tribute to his contributions as a moonwalker on the Apollo 14 lunar mission. For more information, visit www.nasa.gov/topics/history/milestones/index.html. Photo credit: NASA/Kim Shiflett

Renal Stone Risk During Spaceflight: Assessment and Countermeasure Validation

NASA Technical Reports Server (NTRS)

Pietrzyk, Robert A.; Whitson, Peggy A.; Sams, Clarence F.; Jones, Jeffery A.; Smith, Scott M.

2009-01-01

This viewgraph presentation describes the risks of renal stone formation in manned space flight. The contents include: 1) Risk; 2) Evidence; 3) Nephrolithiasis -A Multifactorial Disease; 4) Symptoms/signs; 5) Urolithiasis and Stone Passage; 6) Study Objectives; 7) Subjects; 8) Methods; 9) Investigation Results; 10) Potassium Citrate; 11) Calcium Balance; 12) Case Study; 13) Significant Findings; 14) Risk Mitigation Strategies and Recommended Actions; and 15) Future Potential.

Spaceflight tracking and data network operational reliability computer output for MTBF and availability. Appendix V to CSC-1-395

NASA Technical Reports Server (NTRS)

Seneca, V. I.; Mlynarczyk, R. H.

1974-01-01

Tables of data are provided to show the availability of Skylab data to selected ground stations during the phases of Skylab preflight, Skylab unmanned condition, and Skylab manned condition. The mean time between failure (MTBF) of the same Skylab functions is tabulated for the selected ground stations. All reliability data are based on a 90 percent confidence interval.

Space exploration, Mars, and the nervous system.

PubMed

Kalb, Robert; Solomon, David

2007-04-01

When human beings venture back to the moon and then on to Mars in the coming decade or so, we will be riding on the accumulated data and experience from approximately 50 years of manned space exploration. Virtually every organ system functions differently in the absence of gravity, and some of these changes are maladaptive. From a biologic perspective, long duration spaceflight beyond low Earth orbit presents many unique challenges. Astronauts traveling to Mars will live in the absence of gravity for more than 1 year en route and will have to transition between weightlessness and planetary gravitational forces at the beginning, middle, and end of the mission. We discuss some of what is known about the effects of spaceflight on nervous system function, with emphasis on the neuromuscular and vestibular systems because success of a Mars mission will depend on their proper functioning.

The Role and Training of NASA Astronauts in the Post-Shuttle Era

NASA Technical Reports Server (NTRS)

2011-01-01

In May 2010 the National Research Council (NRC) was asked by NASA to address several questions related to the Astronaut Corps. The NRC's Committee on Human Spaceflight Crew Operations was tasked to: 1. How should the role and size of the activities managed by the Johnson Space Center Flight Crew Operations Directorate change following space shuttle retirement and completion of the assembly of the International Space Station (ISS)? 2. What are the requirements for crew-related ground-based facilities after the Space Shuttle program ends? 3. Is the fleet of aircraft used for training the Astronaut Corps a cost-effective means of preparing astronauts to meet the requirements of NASA's human spaceflight program? Are there more cost-effective means of meeting these training requirements? Although the future of NASA's human spaceflight program has garnered considerable discussion in recent years, and there is considerable uncertainty about what that program will involve in the coming years, the committee was not tasked to address whether or not human spaceflight should continue, or what form it should take. The committee's task restricted it to studying those activities managed by the Flight Crew Operations Directorate, or those closely related to its activities, such as crew-related ground-based facilities and the training aircraft.

Preparing for the High Frontier: The Role and Training of NASA Astronauts in the Post- Space Shuttle Era

NASA Technical Reports Server (NTRS)

2011-01-01

In May 2010, the National Research Council (NRC) was asked by NASA to address several questions related to the Astronaut Corps. The NRC s Committee on Human Spaceflight Crew Operations was tasked to answer several questions: 1. How should the role and size of the activities managed by the Johnson Space Center Flight Crew Operations Directorate change after space shuttle retirement and completion of the assembly of the International Space Station (ISS)? 2. What are the requirements for crew-related ground-based facilities after the Space Shuttle program ends? 3. Is the fleet of aircraft used for training the Astronaut Corps a cost-effective means of preparing astronauts to meet the requirements of NASA s human spaceflight program? Are there more cost-effective means of meeting these training requirements? Although the future of NASA s human spaceflight program has garnered considerable discussion in recent years and there is considerable uncertainty about what the program will involve in the coming years, the committee was not tasked to address whether human spaceflight should continue or what form it should take. The committee s task restricted it to studying activities managed by the Flight Crew Operations Directorate or those closely related to its activities, such as crew-related ground-based facilities and the training aircraft.

The Effects of Training on Anxiety and Task Performance in Simulated Suborbital Spaceflight.

PubMed

Blue, Rebecca S; Bonato, Frederick; Seaton, Kimberly; Bubka, Andrea; Vardiman, Johnené L; Mathers, Charles; Castleberry, Tarah L; Vanderploeg, James M

2017-07-01

In commercial spaceflight, anxiety could become mission-impacting, causing negative experiences or endangering the flight itself. We studied layperson response to four varied-length training programs (ranging from 1 h-2 d of preparation) prior to centrifuge simulation of launch and re-entry acceleration profiles expected during suborbital spaceflight. We examined subject task execution, evaluating performance in high-stress conditions. We sought to identify any trends in demographics, hemodynamics, or similar factors in subjects with the highest anxiety or poorest tolerance of the experience. Volunteers participated in one of four centrifuge training programs of varied complexity and duration, culminating in two simulated suborbital spaceflights. At most, subjects underwent seven centrifuge runs over 2 d, including two +Gz runs (peak +3.5 Gz, Run 2) and two +Gx runs (peak +6.0 Gx, Run 4) followed by three runs approximating suborbital spaceflight profiles (combined +Gx and +Gz, peak +6.0 Gx and +4.0 Gz). Two cohorts also received dedicated anxiety-mitigation training. Subjects were evaluated on their performance on various tasks, including a simulated emergency. Participating in 2-7 centrifuge exposures were 148 subjects (105 men, 43 women, age range 19-72 yr, mean 39.4 ± 13.2 yr, body mass index range 17.3-38.1, mean 25.1 ± 3.7). There were 10 subjects who withdrew or limited their G exposure; history of motion sickness was associated with opting out. Shorter length training programs were associated with elevated hemodynamic responses. Single-directional G training did not significantly improve tolerance. Training programs appear best when high fidelity and sequential exposures may improve tolerance of physical/psychological flight stressors. The studied variables did not predict anxiety-related responses to these centrifuge profiles.Blue RS, Bonato F, Seaton K, Bubka A, Vardiman JL, Mathers C, Castleberry TL, Vanderploeg JM. The effects of training on anxiety and task performance in simulated suborbital spaceflight. Aerosp Med Hum Perform. 2017; 88(7):641-650.

Research Opportunities in Nutrition and Metabolism in Space

NASA Technical Reports Server (NTRS)

Altman, Philip L. (Editor); Fisher, Kenneth D. (Editor)

1986-01-01

The objectives of the Life Sciences Research Office (LSRO) study on nutrient requirements for meeting metabolic needs in manned space flights are as follows: review extant knowledge on the subject; identify significant gaps in knowledge; formulate suggestions for possible research; and produce a documented report of the foregoing items that can be used for program planning. In accordance with NASA's request for this study, the report focuses on issues of nutrition and metabolism that relate primarily to the contemplated United States Space Station, secondarily to the Shuttle Program as an orbital test bed for operational studies, and incidentally to scenarios for future long-term space flights. Members of the LSRO ad hoc Working Group on Nutrition and Metabolism were provided with pertinent articles and summaries on the subject. At the meeting of the Working Group, presentations were made by NASA Headquarters program staff on past experiences relative to space-flight nutrition and metabolism, as well as scenarios for future flights. The discussions of the ad hoc Working Group focused on the following: (1) metabolic needs related to work and exercise; (2) nutrients required to meet such needs; (3) food types, management, and records; and (4) nutritional amelioration or prevention of space-related physiological and behavioral changes.

21st Century extravehicular activities: Synergizing past and present training methods for future spacewalking success

NASA Astrophysics Data System (ADS)

Moore, Sandra K.; Gast, Matthew A.

2010-10-01

Neil Armstrong's understated words, "That's one small step for man, one giant leap for mankind" were spoken from Tranquility Base forty years ago. Even today, those words resonate in the ears of millions, including many who had yet to be born when man first landed on the surface of the moon. By their very nature, and in the true spirit of exploration, extravehicular activities (EVAs) have generated much excitement throughout the history of manned spaceflight. From Ed White's first spacewalk in the June of 1965, to the first steps on the moon in 1969, to the expected completion of the International Space Station (ISS), the ability to exist, live and work in the vacuum of space has stood as a beacon of what is possible. It was NASA's first spacewalk that taught engineers on the ground the valuable lesson that successful spacewalking requires a unique set of learned skills. That lesson sparked extensive efforts to develop and define the training requirements necessary to ensure success. As focus shifted from orbital activities to lunar surface activities, the required skill set and subsequently the training methods changed. The requirements duly changed again when NASA left the moon for the last time in 1972 and have continued to evolve through the SkyLab, Space Shuttle, and ISS eras. Yet because the visits to the moon were so long ago, NASA's expertise in the realm of extra-terrestrial EVAs has diminished. As manned spaceflight again shifts its focus beyond low earth orbit, EVA's success will depend on the ability to synergize the knowledge gained over 40+ years of spacewalking to create a training method that allows a single crewmember to perform equally well, whether performing an EVA on the surface of the Moon, while in the vacuum of space, or heading for a rendezvous with Mars. This paper reviews NASA's past and present EVA training methods and extrapolates techniques from both to construct the basis for future EVA astronaut training.

21st Century Extravehicular Activities: Synergizing Past and Present Training Methods for Future Spacewalking Success

NASA Technical Reports Server (NTRS)

Moore, Sandra K.; Gast, Matthew A.

2009-01-01

Neil Armstrong's understated words, "That's one small step for man, one giant leap for mankind." were spoken from Tranquility Base forty years ago. Even today, those words resonate in the ears of millions, including many who had yet to be born when man first landed on the surface of the moon. By their very nature, and in the the spirit of exploration, extravehicular activities (EVAs) have generated much excitement throughout the history of manned spaceflight. From Ed White's first space walk in June of 1965, to the first steps on the moon in 1969, to the expected completion of the International Space Station (ISS), the ability to exist, live and work in the vacuum of space has stood as a beacon of what is possible. It was NASA's first spacewalk that taught engineers on the ground the valuable lesson that successful spacewalking requires a unique set of learned skills. That lesson sparked extensive efforts to develop and define the training requirements necessary to ensure success. As focus shifted from orbital activities to lunar surface activities, the required skill-set and subsequently the training methods, changed. The requirements duly changed again when NASA left the moon for the last time in 1972 and have continued to evolve through the Skylab, Space Shuttle; and ISS eras. Yet because the visits to the moon were so long ago, NASA's expertise in the realm of extra-terrestrial EVAs has diminished. As manned spaceflight again shifts its focus beyond low earth orbit, EVA success will depend on the ability to synergize the knowledge gained over 40+ years of spacewalking to create a training method that allows a single crewmember to perform equally well, whether performing an EVA on the surface of the Moon, while in the vacuum of space, or heading for a rendezvous with Mars. This paper reviews NASA's past and present EVA training methods and extrapolates techniques from both to construct the basis for future EVA astronaut training.

Investigation of the Influence of Microgravity on Transport Mechanisms in a Virtual Spaceflight Chamber: A Ground-Based Program

NASA Technical Reports Server (NTRS)

Trolinger, James D.; Lal, Ravindra B.; Rangel, Roger; Witherow, William; Rogers, Jan

2001-01-01

The IML-1 Spaceflight produced over 1000 holograms of a well-defined particle field in the low g Spacelab environment; each containing as much as 1000 megabytes of information. This project took advantage of these data and the concept of holographic "virtual" spaceflight to advance the understanding of convection in the space shuttle environment, g-jitter effects on crystal growth, and complex transport phenomena in low Reynolds number flows. The first objective of the proposed work was to advance the understanding of microgravity effects on crystal growth. This objective was achieved through the use of existing holographic data recorded during the IML-1 Spaceflight. The second objective was to design a spaceflight experiment that exploits the "virtual space chamber concept" in which holograms of space chambers can provide a virtual access to space. This led to a flight definition project, which is now underway under a separate contract known as SHIVA, Spaceflight Holography Investigation in a Virtual Apparatus.

Obama sets out NASA's new mission to Mars

NASA Astrophysics Data System (ADS)

Gwynne, Peter

2010-05-01

US President Barack Obama has announced a new direction for NASA that includes plans to send astronauts to an asteroid by 2025. Speaking last month at Florida's Kennedy Space Center, the launching location for US manned spaceflights, Obama also called for a new "heavy-lift" rocket design to take astronauts on a mission to orbit Mars by the mid-2030s that will "eventually" be used to transport humans to the Martian surface.

Safety and Mission Assurance: A NASA Perspective

NASA Technical Reports Server (NTRS)

Higginbotham, Scott A.

2016-01-01

Manned spaceflight is an incredibly complex and inherently risky human endeavor. As the result of the lessons learned through years of triumph and tragedy, the National Aeronautics and Space Administration (NASA) has embraced a comprehensive and integrated approach to the challenge of ensuring safety and mission success. This presentation will provide an overview of some of the techniques employed in this effort, with a focus on the processing operations performed at the Kennedy Space Center (KSC).

International collaboration on Russian spacecraft and the case for free flyer biosatellites

NASA Technical Reports Server (NTRS)

Grindeland, Richard E.; Ilyin, Eugene A.; Holley, Daniel C.; Skidmore, Michael G.

2005-01-01

Animal research has been critical to the initiation and progress of space exploration. Animals were the original explorers of "space" two centuries ago and have played a crucial role by demonstrating that the space environment, with precautions, is compatible with human survival. Studies of mammals have yielded much of our knowledge of space physiology. As spaceflights to other planets are anticipated, animal research will continue to be essential to further reveal space physiology and to enable the longer missions. Much of the physiology data collected from space was obtained from the Cosmos (Bion) spaceflights, a series of Russian (Soviet)-International collaborative flights, over a 22 year period, which employed unmanned, free flyer biosatellites. Begun as a Soviet-only program, after the second flight the Russians invited American and other foreign scientists to participate. This program filled the 10 year hiatus between the last US biosatellite and the first animal experiments on the shuttles. Of the 11 flights in the Cosmos program nine of them were international; the flights continued over the years regardless of political differences between the Soviet Union and the Western world. The science evolved from sharing tissues to joint international planning and development, and from rat postmortem tissue analysis to in vivo measurements of a host of monkey physiological parameters during flight. Many types of biological specimens were carried on the modified Vostok spacecraft, but only the mammalian studies are discussed herein. The types of studies done encompass the full range of physiology and have begun to answer "critical" questions of space physiology posed by various ad hoc committees. The studies have not only yielded a prodigious and significant body of data, they have also introduced some new perspectives in physiology. A number of the physiological insights gained are relevant to physiology on Earth. The Cosmos flights also added significantly to flight-related technology, some of which also has application on our planet. In summary, the Cosmos biosatellite flights were extremely productive and of low cost. The Bion vehicles are versatile in that they can be placed into a variety of orbits and altitudes, and can carry radiation sources or other hazardous material which cannot be carried on manned vehicles. With recent advances in sensor, robotic, and data processing technology, future free flyers will be even more productive, and will largely preclude the need to fly animal experiments on manned vehicles. Currently, mammalian researchers do not have access to space for an unknown time, seriously impeding the advancement and understanding of space physiology during long duration missions. Initiation of a new, international program of free flyer biosatellites is critical to our further understanding of space physiology, and essential to continued human exploration of space.

The ISS flight of Richard Garriott: a template for medicine and science investigation on future spaceflight participant missions.

PubMed

Jennings, Richard T; Garriott, Owen K; Bogomolov, Valery V; Pochuev, Vladimir I; Morgun, Valery V; Garriott, Richard A

2010-02-01

A total of eight commercial spaceflight participants have launched to the International Space Station (ISS) on Soyuz vehicles. Based on an older mean age compared to career astronauts and an increased prevalence of medical conditions, spaceflight participants have provided the opportunity to learn about the effect of space travel on crewmembers with medical problems. The 12-d Soyuz TMA-13/12 ISS flight of spaceflight participant Richard Garriott included medical factors that required preflight intervention, risk mitigation strategies, and provided the opportunity for medical study on-orbit. Equally important, Mr. Garriott conducted extensive medical, scientific, and educational payload operations during the flight. These included 7 medical experiments and a total of 15 scientific projects such as protein crystal growth, Earth observations/photography, educational projects with schools, and amateur radio. The medical studies included the effect of microgravity on immune function, sleep, bone loss, corneal refractive surgery, low back pain, motion perception, and intraocular pressure. The overall mission success resulted from non-bureaucratic agility in mission planning, cooperation with investigators from NASA, ISS, International Partners, and the Korean Aerospace Research Institute, in-flight support and leadership from a team with spaceflight and Capcom experience, and overall mission support from the ISS program. This article focuses on science opportunities that suborbital and orbital spaceflight participant flights offer and suggests that the science program on Richard Garriott's flight be considered a model for future orbital and suborbital missions. The medical challenges are presented in a companion article.

Computers in Spaceflight: the NASA Experience

NASA Technical Reports Server (NTRS)

Tomayko, James E.

1988-01-01

This book examines the computer systems used in actual spaceflight or in close support of it. Each chapter deals with either a specific program, such as Gemini or Apollo onboard computers, or a closely related set of systems, such as launch processing or mission control. A glossary of computer terms is included.

An overview of the endocrine and metabolic changes in manned space flight

NASA Technical Reports Server (NTRS)

Leach, C. S.

1981-01-01

Analyses of endocrinological and metabolic data from humans during spaceflight, particularly the Skylab crews, are summarized to define the levels of knowledge of these processes and the techniques for studying them. The glomerular filtration rate was tested by urine and blood samples, yielding indications of a creatinine clearance increase. The mechanisms for an increase of free water clearance, implying an increase of antidiuretic hormone, are uncertain, and tests are also under way to evaluate the role of prostaglandins in-flight, to account for decreases in catecholamine excretion. Bone mineral losses of 7.9% were observed at the end of 84 days, and processes are suggested for the calcium metabolism. Finally, the observation of almost universal weight loss among space crewmembers is examined, and a loss of muscle tone due to decreased metabolic efficiency is cited as a feature of long duration spaceflight.

Radiation shielding estimates for manned Mars space flight.

PubMed

Dudkin, V E; Kovalev, E E; Kolomensky, A V; Sakovich, V A; Semenov, V F; Demin, V P; Benton, E V

1992-01-01

In the analysis of the required radiation shielding protection of spacecraft during a Mars flight, specific effects of solar activity (SA) on the intensity of galactic and solar cosmic rays were taken into consideration. Three spaceflight periods were considered: (1) maximum SA; (2) minimum SA; and (3) intermediate SA, when intensities of both galactic and solar cosmic rays are moderately high. Scenarios of spaceflights utilizing liquid-propellant rocket engines, low- and intermediate-thrust nuclear electrojet engines, and nuclear rocket engines, all of which have been designed in the Soviet Union, are reviewed. Calculations were performed on the basis of a set of standards for radiation protection approved by the U.S.S.R. State Committee for Standards. It was found that the lowest estimated mass of a Mars spacecraft, including the radiation shielding mass, obtained using a combination of a liquid propellant engine with low and intermediate thrust nuclear electrojet engines, would be 500-550 metric tons.

Read You Loud and Clear! The Story of NASA's Spaceflight Tracking and Data Network

NASA Technical Reports Server (NTRS)

Tsiao, Sunny

2008-01-01

A historical account is provided of NASA's Spaceflight Tracking and Data Network (STDN), starting with its formation in the late 1950s to what it is today in the first decade of the 21st century. It traces the roots of the tracking network from its beginnings at the White Sands Missile Range in New Mexico to the Tracking and Data Relay Satellite System space-based constellation of today. The story spans the early days of satellite tracking using the Minitrack Network, through the expansion of the Satellite Tracking and Data Acquisition Network and the Manned Space Flight Network, and finally, to the Space and Ground networks of today. These accounts tell how international goodwill and foreign cooperation were crucial to the operation of the network and why the space agency chose to build the STDN as it did.

Hypertension and orthostatic hypotension in applicants for spaceflight training and spacecrews: a review of medical standards.

PubMed

Fuchs, H S

1983-01-01

The inauguration of NASA of the position of Payload Specialists for SHUTTLE-SPACELAB flights has broken the tradition of restrictive medical physical standards in several ways: by reducing physical requirements and extensive training; by permitting the selection of older individuals and women; by selecting individuals who may fly only one or several missions and do not spend an entire career in space activities. Experience with Payload Specialists to be gained during the forthcoming SPACELAB missions, observing man in spaceflight step by step on an incremental basis, will provide valuable data for modifying the medical standards for Payload Specialists, Space Station Technicians, and Space Support Personnel who perform routine work rather than peculiar tasks. Such revisions necessarily include a modification of traditional blood pressure standards. In this paper I review the history and evolution of these standards in aeronautics and astronautics.

Hypertension and orthostatic hypotension in applicants for spaceflight training and spacecrews: A review of medical standards

NASA Astrophysics Data System (ADS)

Fuchs, Heinz S.

The inauguration of NASA of the position of Payload Specialists for SHUTTLE-SPACELAB flights has broken the tradition of restrictive medical physical standards in several ways: by reducing physical requirements and extensive training; by permitting the selection of older individuals and women; by selecting individuals who may fly only one or several missions and do not spend an entire career in space activities. Experience with Payload Specialists to be gained during the forthcoming SPACELAB missions, observing man in spaceflight step by step on an incremental basis, will provide valuable data for modifying the medical standards for Payload Specialists, Space Station Technicians, and Space Support Personnel who perform routine work rather than peculiar tasks. Such revisions necessarily include a modification of traditional blood pressure standards. In this paper I review the history and evolution of these standards in aeronautics and astronautics.

Biological filters and their use in potable water filtration systems in spaceflight conditions.

PubMed

Thornhill, Starla G; Kumar, Manish

2018-05-01

Providing drinking water to space missions such as the International Space Station (ISS) is a costly requirement for human habitation. To limit the costs of water transport, wastewater is collected and purified using a variety of physical and chemical means. To date, sand-based biofilters have been designed to function against gravity, and biofilms have been shown to form in microgravity conditions. Development of a universal silver-recycling biological filter system that is able to function in both microgravity and full gravity conditions would reduce the costs incurred in removing organic contaminants from wastewater by limiting the energy and chemical inputs required. This paper aims to propose the use of a sand-substrate biofilter to replace chemical means of water purification on manned spaceflights. Copyright © 2018 The Committee on Space Research (COSPAR). Published by Elsevier Ltd. All rights reserved.

Human Research Program: 2010 Annual Report

NASA Technical Reports Server (NTRS)

2010-01-01

2010 was a year of solid performance for the Human Research Program in spite of major changes in NASA's strategic direction for Human Spaceflight. Last year, the Program completed the final steps in solidifying the management foundation, and in 2010 we achieved exceptional performance from all elements of the research and technology portfolio. We transitioned from creating building blocks to full execution of the management tools for an applied research and technology program. As a team, we continue to deliver the answers and technologies that enable human exploration of space. While the Agency awaits strategic direction for human spaceflight, the Program is well positioned and critically important to helping the Agency achieve its goals.

This New Ocean: A History of Project Mercury

NASA Technical Reports Server (NTRS)

Swenson, Loyd S., Jr.; Grimwood, James M.; Alexander, Charles C.

1998-01-01

When Congress created the National Aeronautics and Space Administration (NASA) in 1958, it charged NASA with the responsibility "to contribute materially to . . . the expansion of human knowledge of phenomena in the atmosphere and space" and "provide for the widest practicable and appropriate dissemination of information concerning its activities and the results thereof." NASA wisely interpreted this mandate to include responsibility for documenting the epochal progress of which it is the focus. The result has been the development of a historical program by NASA as unprecedented as the task of extending man's mobility beyond his planet. This volume is not only NASA's accounting of its obligation to disseminate information to our current generation of Americans. It also fulfills, as do all of NASA's future-oriented scientific-technological activities, the further obligation to document the present as the heritage of the future. The wide-ranging NASA history program includes chronicles of day-to-day space activities; specialized studies of particular fields within space science and technology; accounts of NASA's efforts in organization and management, where its innovations, while less known to the public than its more spectacular space shots, have also been of great significance; narratives of the growth and expansion of the space centers throughout the country, which represent in microcosm many aspects of NASA's total effort; program histories, tracing the successes- and failures- of the various projects that mark man's progress into the Space Age; and a history of NASA itself, incorporating in general terms the major problems and challenges, and the responses thereto, of our entire civilian space effort. The volume presented here is a program history, the first in a series telling of NASA's pioneering steps into the Space Age. It deals with the first American manned-spaceflight program: Project Mercury. Although some academicians might protest that this is "official" history, it is official only in the fact that it has been prepared and published with the support and cooperation of NASA. It is not "official" history in the sense of presenting a point of view supposedly that of NASA officialdom-if anyone could determine what the "point of view" of such a complex organism might be. Certainly, the authors were allowed to pursue their task with the fullest freedom and in accordance with the highest scholarly standards of the history profession.

Seeking a Human Spaceflight Program Worthy of a Great Nation. Review of U.S. Human Spaceflight Plans Committee

DTIC Science & Technology

2009-10-01

human spaceflight plan is its affordability. In the way of background , Fig- ures 1-4, 1- 5 and 1-6 present the overall NASA bud- get trend over time...build upon the experience gained from prior ones. All as- sume a first flight to lunar orbit, and then to the Lagrange points, and then to near-Earth...and a description of the scenarios considered for inclusion in the integrated options presented in this report. 4.1.1 Background . The Space

JPRS Report, Science & Technology, Manned Spaceflight Technology Symposium.

DTIC Science & Technology

1988-07-12

properties and degradation of the surface, i.e., declines in structural functions caused by erosion, to rupture, with long-range effects still a matter of...system, although we are aware of some risks of contingency. Nevertheless, it is a matter of course that we make efforts to make a safer system feasible...earth may soon become a planet with a circular ring similar to Saturn. Important matters include to what extent the amount of debris will increase

Overwintering in the antarctica as an analog for long term manned spaceflight

NASA Astrophysics Data System (ADS)

Tanaka, M.; Watanabe, S.

1994-08-01

As a part of Polar Psychological Project planned by SCAR group on Antarctic-Space-Related-Human-Factors-Research, a series of psychological tests were conducted on the Japanese wintering-over personnel. The main purpose of the research was to study the behavioral characteristics, such as depression, insomnia, anxiety, and hostility, which might develop during the course of wintering-over period, and it involves a detailed study of the individuals and interpersonal relationship.

Voluntary immunomodulation: potentiality and implications for long-duration manned space-flights

NASA Astrophysics Data System (ADS)

Geuna, Stefano

The influence of psychological and neural factors on immunologic activity has been dedicated a growing interest over the past fifteen years, since the publication ofPsychoneuroimmunology by Robert Ader in 1981. Studies on this topic gave evidence for bi-directional communication between psychosocial, behavioural, neuroanatomical and neuroendocrine processes with the immune system and the detrimental effects of various stressors, physical and psychological, on immune reactions were widely investigated with reports of stress-induced changes in immune paramenters and immunocompetence. Much of the evidence support the notion that stress is associated with an increase in those diseases against which the immune system defends. Recently, several studies showed that immune functions can be influenced voluntarily and the term voluntary immunomodulation was coined to describe the use of various hypnosis-like and relaxation/imagery techniques for the self-regulation of immune activity. Alterations in the immune regulatory system are one of the most critical issues to be addressed in relation to crew health management during space missions, especially long-term ones. Providing crewmembers with a tool to enhance immunocompetence might be of great value to defend against some severe diseases, such as cancer and infectious illness, which may be elicited in outer space. In this view, a critical assessment of the potential usefulness of voluntary immunomodulation for crew health maintenance during manned space-flight is presented and discussed.

Evaluation of Space Food for Commercial Astronauts

NASA Astrophysics Data System (ADS)

Ahlstrom, Britt Karin

As commercial aerospace companies advance toward manned spaceflight, they must overcome many hurdles - not only technical, but also human. One of the greatest human challenges they face is food. Throughout the history of human spaceflight, astronauts have primarily eaten food developed by government space agencies. Now, with manned commercial flights on the horizon, astronauts will be provided with an entirely new diet - one comprised of commercially available, ready-to-eat food. Yet will this diet keep astronauts nourished, satisfied with their diet, and both psychologically and physically healthy? The purpose of this parallel crossover design study was to evaluate (a) nutrient intake, (b) food satisfaction, (c) psychological health, and (d) physical health in commercial aerospace employees (N = 7) as they ate a diet of commercial, ready-to-eat food for four days, as compared to eating as normal for four days. Findings from this study showed that the ready-to-eat diet did not lead to any significant changes in caloric intake, psychological health, or physical health, aside from weight loss. It is not clear whether this weight loss was due to the loss of body fat, muscle, or water. When eating the ready-to-eat food, participants reported being slightly less satisfied with the variety, reported lower cravings for sweets, and reported the food was slightly less hedonically rewarding. In post-study interviews, participants reported they wanted to see more meats, fruits, vegetables, and desserts added to the ready-to-eat diet, so as to provide more meal-like structure. Overall, these findings show the diet could be used in commercial spaceflight after making simple changes. The diet could also be used by individuals in remote areas on Earth and to provide food assistance to individuals in disaster or emergency situations. Due to the increasing popularity of ready-to-eat food around the world, these findings also provide knowledge about the potential consequences of modern eating trends.

Evidence Report: Risk of Adverse Health Effects Due to Host-Microorganism Interactions

NASA Technical Reports Server (NTRS)

Ott, C. Mark; Oubre, Cherie; Wallace, Sarah; Mehta, Satish; Pierson, Duane

2016-01-01

While preventive measures limit the presence of many medically significant microorganisms during spaceflight missions, microbial infection of crewmembers cannot be completely prevented. Spaceflight experiments over the past 50 years have demonstrated a unique microbial response to spaceflight culture, although the mechanisms behind those responses and their operational relevance were unclear. In 2007, the operational importance of these microbial responses was emphasized as the results of an experiment aboard STS-115 demonstrated that the enteric pathogen Salmonella enterica serovar Typhimurium (S. Typhimurium) increased in virulence in a murine model of infection. The experiment was reproduced in 2008 aboard STS-123 confirming this finding. In response to these findings, the Institute of Medicine of the National Academies recommended that NASA investigate this risk and its potential impact on the health of the crew during spaceflight. NASA assigned this risk to the Human Research Program. To better understand this risk, evidence has been collected and reported from both spaceflight analog systems and actual spaceflight including Mir, Space Shuttle, and ISS missions. Although the performance of virulence studies during spaceflight are challenging and often impractical, additional information has been and continues to be collected to better understand the risk to crew health. Still, the uncertainty concerning the extent and severity of these alterations in host-microorganism interactions is very large and requires more investigation as the focus of human spaceflight shifts to longer-duration exploration class missions.

NASA's Human Research Program at The Glenn Research Center: Progress and Opportunities

NASA Technical Reports Server (NTRS)

Nall, Marsha; Griffin, DeVon; Myers, Jerry; Perusek, Gail

2008-01-01

The NASA Human Research Program is aimed at correcting problems in critical areas that place NASA human spaceflight missions at risk due to shortfalls in astronaut health, safety and performance. The Glenn Research Center (GRC) and partners from Ohio are significant contributors to this effort. This presentation describes several areas of GRC emphasis, the first being NASA s path to creating exercise hardware requirements and protocols that mitigate the effects of long duration spaceflight. Computational simulations will be a second area that is discussed. This includes deterministic models that simulate the effects of spaceflight on the human body, as well as probabilistic models that bound and quantify the probability that adverse medical incidents will happen during an exploration mission. Medical technology development for exploration will be the final area to be discussed.

Longevity of the Human Spaceflight Program

NASA Astrophysics Data System (ADS)

Gott, J. Richard

2007-02-01

The longevity of the human spaceflight program is important to our survival prospects. On May 27, 1993 I proposed a method for estimating future longevity, based on past observed longevity using the Copernican Principle: if your observation point is not special the 95% confidence level prediction of future longevity is between (1/39)th and 39 times the past longevity. The prediction for the future longevity of the human spaceflight program (then 32 years old) was greater than 10 months but less than 1248 years. We have already passed the lower limit. This Copernican formula has been tested a number of times, correctly predicting, among other things, future longevities of Broadway plays and musicals, and the Conservative Government in the United Kingdom. Recently, a study of future longevities of the 313 world leaders in power on May 27, 1993 has been completed. Assuming none still in office serve past age 100, the success rate of the 95% Copernican Formula is currently 94.55% with only one case (out of 313) left to be decided. The human spaceflight program has not been around long and so there is the danger its future will not be long enough to allow us to colonize off the earth. Policy implications are discussed. A smart plan would be to try to establish a self-supporting colony on Mars in the next 45 years. This should not require sending any more tons of material into space in the next 45 years than we have in the last 45 years.

A survey of some regenerative physico-chemical life support technology

NASA Technical Reports Server (NTRS)

Wydeven, Theodore

1988-01-01

To date, manned spaceflight has used the relatively simple support methodology of bringing all the necessary water, oxygen, and food for the duration of the mission, and collecting and storing waste products for return to Earth. This is referred to as an open system. It was recognized early, as manned missions became longer and crew size increased, that the weight, volume, and transportation penalties of storing or routinely resupplying consumables would at some point become too expensive. Since the early 1960's regenerative ECLSS technology has been under development, and there now exists a foundation in both systems definition and subsystem technology to support long-duration manned missions. In many cases this development has reached the engineering prototype stage for physico-chemical subsystems and in this article some of these subsystems are described. Emphasis is placed on physico-chemical waste conversion and related processes which provide sustenance and not on environmental factors or subsystems, e.g., temperature and humidity control, spacecraft architecture, lighting, etc.

Advantage of Animal Models with Metabolic Flexibility for Space Research Beyond Low Earth Orbit

NASA Technical Reports Server (NTRS)

Griko, Yuri V.; Rask, Jon C.; Raychev, Raycho

2017-01-01

As the world's space agencies and commercial entities continue to expand beyond Low Earth Orbit (LEO), novel approaches to carry out biomedical experiments with animals are required to address the challenge of adaptation to space flight and new planetary environments. The extended time and distance of space travel along with reduced involvement of Earth-based mission support increases the cumulative impact of the risks encountered in space. To respond to these challenges, it becomes increasingly important to develop the capability to manage an organism's self-regulatory control system, which would enable survival in extraterrestrial environments. To significantly reduce the risk to animals on future long duration space missions, we propose the use of metabolically flexible animal models as "pathfinders," which are capable of tolerating the environmental extremes exhibited in spaceflight, including altered gravity, exposure to space radiation, chemically reactive planetary environments and temperature extremes. In this report we survey several of the pivotal metabolic flexibility studies and discuss the importance of utilizing animal models with metabolic flexibility with particular attention given to the ability to suppress the organism's metabolism in spaceflight experiments beyond LEO. The presented analysis demonstrates the adjuvant benefits of these factors to minimize damage caused by exposure to spaceflight and extreme planetary environments. Examples of microorganisms and animal models with dormancy capabilities suitable for space research are considered in the context of their survivability under hostile or deadly environments outside of Earth. Potential steps toward implementation of metabolic control technology in spaceflight architecture and its benefits for animal experiments and manned space exploration missions are discussed.

Advantage of Animal Models with Metabolic Flexibility for Space Research Beyond Low Earth Orbit

NASA Technical Reports Server (NTRS)

Griko, Yuri V.; Rask, Jon C.; Raychev, Raycho

2017-01-01

As the worlds space agencies and commercial entities continue to expand beyond Low Earth Orbit (LEO), novel approaches to carry out biomedical experiments with animals are required to address the challenge of adaptation to space flight and new planetary environments. The extended time and distance of space travel along with reduced involvement of Earth-based mission support increases the cumulative impact of the risks encountered in space. To respond to these challenges, it becomes increasingly important to develop the capability to manage an organisms self-regulatory control system, which would enable survival in extraterrestrial environments. To significantly reduce the risk to animals on future long duration space missions, we propose the use of metabolically flexible animal models as pathfinders, which are capable of tolerating the environmental extremes exhibited in spaceflight, including altered gravity, exposure to space radiation, chemically reactive planetary environments and temperature extremes.In this report we survey several of the pivotal metabolic flexibility studies and discuss the importance of utilizing animal models with metabolic flexibility with particular attention given to the ability to suppress the organism's metabolism in spaceflight experiments beyond LEO. The presented analysis demonstrates the adjuvant benefits of these factors to minimize damage caused by exposure to spaceflight and extreme planetary environments. Examples of microorganisms and animal models with dormancy capabilities suitable for space research are considered in the context of their survivability under hostile or deadly environments outside of Earth. Potential steps toward implementation of metabolic control technology in spaceflight architecture and its benefits for animal experiments and manned space exploration missions are discussed.

Compression Stockings May Ameliorate Orthostatic Intolerance in Astronauts After Short-Duration Space Flight

NASA Technical Reports Server (NTRS)

Platts, Steven H.; Lee, Stuart M. C.; Westby, Christian M.; Ribeiro, L. Christine; Stenger, Michael B.

2011-01-01

Orthostatic intolerance following spaceflight has been observed since the early days of manned spaceflight, and no countermeasure has been 100% effective. During re-entry NASA astronauts currently wear an inflatable anti-gravity suit (AGS) which compresses the legs and abdomen, but this device is uncomfortable and loses effectiveness upon egress from the Space Shuttle. We previously reported that foot-to-thigh, gradient compression stockings were comfortable and effective during standing after Shuttle missions. More recently we showed in a ground-based model of spaceflight that the addition of splanchnic compression to the foot-to-thigh compression stockings, creating foot-to-breast high compression, improved orthostatic tolerance in hypovolemic subjects to a level similar to the AGS. Purpose: To evaluate a new three-piece, foot-to-breast high gradient compression garment as a countermeasure to post-spaceflight orthostatic intolerance. Methods: Fourteen astronauts completed this experiment (7 control, 7 treatment) following Space Shuttle missions lasting 12-16 days. Treatment subjects were custom-fitted for a three-piece, foot-to-breast high compression garment consisting of shorts and foot-to-thigh stockings. The garments were constructed to provide 55 mmHg compression at the ankle and decreased gradually to 15 mmHg over the abdomen. Orthostatic testing occurred 30 days before flight (without garments) and 2 hours after flight (with garments for treatment group only) on landing day. Blood pressure (BP) and heart rate (HR) were acquired for 2 minutes while the subject lay prone and then for 3.5 minutes after the subject stood. Data are reported as mean +/- SE. Results: The compression garment successfully prevented the tachycardia and hypotension typically seen post-spaceflight. On landing day, treatment subjects had a smaller change in HR (11+/-1 vs. 21+/-4 beats/min, p< or =0.05) and no decrease in systolic BP (2+/-4 vs. -9+/-2 mmHg, p< or =0.05). Garments also received good comfort ratings and were relatively easy to don. Conclusion: In this small group of astronauts, foot-to-breast high gradient compression garments seem to have prevented these negative effects of spaceflight on the cardiovascular responses to standing.

Risk of Adverse Health Effects Due to Host-Microorganism Interactions

NASA Technical Reports Server (NTRS)

Ott, C. Mark; Oubre, Cherie; Castro, Sarah; Mehta, Satish; Pierson, Duane

2015-01-01

While preventive measures limit the presence of many medically significant microorganisms during spaceflight missions, microbial infection of crewmembers cannot be completely prevented. Spaceflight experiments over the past 50 years have demonstrated a unique microbial response to spaceflight culture, although the mechanisms behind those responses and their operational relevance were unclear. In 2007, the operational importance of these microbial responses was emphasized as the results of an experiment aboard STS-115 demonstrated that the enteric pathogen Salmonella enterica serovar Typhimurium (S. Typhimurium) increased in virulence in a murine model of infection. The experiment was reproduced in 2008 aboard STS-123 confirming this finding. In response to these findings, the Institute of Medicine of the National Academies recommended that NASA investigate this risk and its potential impact on the health of the crew during spaceflight. NASA assigned this risk to the Human Research Program. To better understand this risk, evidence has been collected and reported from both spaceflight analog systems and actual spaceflight. Although the performance of virulence studies during spaceflight are challenging and often impractical, additional information has been and continues to be collected to better understand the risk to crew health. Still, the uncertainty concerning the extent and severity of these alterations in host-microorganism interactions is very large and requires more investigation.

GEMINI-TITAN (GT)-11 - EARTH - SKY - DOCKING - OUTER SPACE

NASA Image and Video Library

1966-07-18

S66-46144 (18 July 1966) --- The Gemini-10 spacecraft is successfully docked with the Agena Target Docking Vehicle 5005. The Agena display panel is clearly visible. After docking with the Agena, astronauts John W. Young, command pilot, and Michael Collins, pilot, fired the 16,000-pound thrust engine of Agena-10's primary propulsion system to boost the combined vehicles into an orbit with an apogee of 413 nautical miles to set a new altitude record for manned spaceflight. Photo credit: NASA

KSC-2012-1857

NASA Image and Video Library

2012-02-17

Project Mercury: With Project Mercury, the United States gained its first experience in conducting human space missions that provided scientific and engineering knowledge of astronauts in space. Alan Shepard made history May 5, 1961, as America's first man in space. Less than a year later, John Glenn made the nation’s first orbital flight on Feb. 20, 1962. After two suborbital and three orbital missions, Project Mercury ended with a 22-orbit spaceflight on May 16, 1963. Poster designed by Kennedy Space Center Graphics Department/Greg Lee. Credit: NASA

KSC-2012-1858

NASA Image and Video Library

2012-02-17

Project Mercury: With Project Mercury, the United States gained its first experience in conducting human space missions that provided scientific and engineering knowledge of astronauts in space. Alan Shepard made history May 5, 1961, as America's first man in space. Less than a year later, John Glenn made the nation’s first orbital flight on Feb. 20, 1962. After two suborbital and three orbital missions, Project Mercury ended with a 22-orbit spaceflight on May 16, 1963. Poster designed by Kennedy Space Center Graphics Department/Greg Lee. Credit: NASA

Human Spaceflight The Kennedy Legacy

NASA Image and Video Library

2011-05-25

Actress Nichelle Nichols, best known for her role as communications officer Lieutenant Uhura in the series "Star Trek", sings as she is escorted on stage, Wednesday, May 25, 2011, in the concert hall at the John F. Kennedy Center for the Performing Arts in Washington. The event marked the 50th Anniversary of President John F. Kennedy's Special Message to the Congress on Urgent National Needs in which he stated "landing a man on the moon and returning him safely to earth". Photo Credit: (NASA/Paul E. Alers)

Exercise Countermeasures on ISS: Summary and Future Directions.

PubMed

Loerch, Linda H

2015-12-01

The first decade of the International Space Station Program (ISS) yielded a wealth of knowledge regarding the health and performance of crewmembers living in microgravity for extended periods of time. The exercise countermeasures hardware suite evolved during the last decade to provide enhanced capabilities that were previously unavailable to support human spaceflight, resulting in attenuation of cardiovascular, muscle, and bone deconditioning. The ability to protect crew and complete mission tasks in the autonomous exploration environment will be a critical component of any decision to proceed with manned exploration initiatives.The next decade of ISS habitation promises to be a period of great scientific utilization that will yield both the tools and technologies required to safely explore the solar system. Leading countermeasure candidates for exploration class missions must be studied methodically on ISS over the next decade to ensure protocols and systems are highly efficient, effective, and validated. Lessons learned from the ISS experience to date are being applied to the future, and international cooperation enables us to maximize this exceptional research laboratory.

KSC-2011-3317

NASA Image and Video Library

2011-05-05

CAPE CANAVERAL, Fla. -- From left, Mercury astronaut Scott Carpenter; Kennedy Space Center Director and former astronaut Bob Cabana; Lieutenant General Susan J. Helms, commander of the 14th Air Force and former astronaut; and NASA Administrator Charlie Bolden participate in a celebration at Complex 5/6 on Cape Canaveral Air Force Station in Florida. The celebration was held at the launch site of the first U.S. manned spaceflight May 5, 1961, to mark the 50th anniversary of the flight. Fifty years ago, astronaut Alan Shepard lifted off inside the Mercury capsule, "Freedom 7," atop an 82-foot-tall Mercury-Redstone rocket at 9:34 a.m. EST, sending him on a remarkably successful, 15-minute suborbital flight. The event was attended by more than 200 workers from the original Mercury program and included a re-creation of Shepard's flight and recovery, as well as a tribute to his contributions as a moonwalker on the Apollo 14 lunar mission. For more information, visit www.nasa.gov/topics/history/milestones/index.html. Photo credit: NASA/Kim Shiflett

Systematic Analysis of mRNA and miRNA Expression of 3D-Cultured Neural Stem Cells (NSCs) in Spaceflight.

PubMed

Cui, Yi; Han, Jin; Xiao, Zhifeng; Qi, Yiduo; Zhao, Yannan; Chen, Bing; Fang, Yongxiang; Liu, Sumei; Wu, Xianming; Dai, Jianwu

2017-01-01

Recently, with the development of the space program there are growing concerns about the influence of spaceflight on tissue engineering. The purpose of this study was thus to determine the variations of neural stem cells (NSCs) during spaceflight. RNA-Sequencing (RNA-Seq) based transcriptomic profiling of NSCs identified many differentially expressed mRNAs and miRNAs between space and earth groups. Subsequently, those genes with differential expression were subjected to bioinformatic evaluation using gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes pathway (KEGG) and miRNA-mRNA network analyses. The results showed that NSCs maintain greater stemness ability during spaceflight although the growth rate of NSCs was slowed down. Furthermore, the results indicated that NSCs tended to differentiate into neuron in outer space conditions. Detailed genomic analyses of NSCs during spaceflight will help us to elucidate the molecular mechanisms behind their differentiation and proliferation when they are in outer space.

Spaceflight dynamics 1993; AAS/NASA International Symposium, 8th, Greenbelt, MD, Apr. 26-30, 1993, Parts 1 & 2

NASA Technical Reports Server (NTRS)

Teles, Jerome (Editor); Samii, Mina V. (Editor)

1993-01-01

A conference on spaceflight dynamics produced papers in the areas of orbit determination, spacecraft tracking, autonomous navigation, the Deep Space Program Science Experiment Mission (DSPSE), the Global Positioning System, attitude control, geostationary satellites, interplanetary missions and trajectories, applications of estimation theory, flight dynamics systems, low-Earth orbit missions, orbital mechanics, mission experience in attitude dynamics, mission experience in sensor studies, attitude dynamics theory and simulations, and orbit-related experience. These papaers covered NASA, European, Russian, Japanese, Chinese, and Brazilian space programs and hardware.

KENNEDY SPACE CENTER, FLA. - (From left) Brian Duffy, Lockheed Martin vice president/associate program manager, Mildred Carter and Col. (Ret.) Herbert E. Carter, one of the Tuskegee Airmen, attend a dinner sponsored by the KSC Spaceflight and Life Sciences Office. Col. Carter was a guest speaker at the dinner.

NASA Image and Video Library

2003-07-18

KENNEDY SPACE CENTER, FLA. - (From left) Brian Duffy, Lockheed Martin vice president/associate program manager, Mildred Carter and Col. (Ret.) Herbert E. Carter, one of the Tuskegee Airmen, attend a dinner sponsored by the KSC Spaceflight and Life Sciences Office. Col. Carter was a guest speaker at the dinner.

A platform for real-time online health analytics during spaceflight

NASA Astrophysics Data System (ADS)

McGregor, Carolyn

Monitoring the health and wellbeing of astronauts during spaceflight is an important aspect of any manned mission. To date the monitoring has been based on a sequential set of discontinuous samplings of physiological data to support initial studies on aspects such as weightlessness, and its impact on the cardiovascular system and to perform proactive monitoring for health status. The research performed and the real-time monitoring has been hampered by the lack of a platform to enable a more continuous approach to real-time monitoring. While any spaceflight is monitored heavily by Mission Control, an important requirement within the context of any spaceflight setting and in particular where there are extended periods with a lack of communication with Mission Control, is the ability for the mission to operate in an autonomous manner. This paper presents a platform to enable real-time astronaut monitoring for prognostics and health management within space medicine using online health analytics. The platform is based on extending previous online health analytics research known as the Artemis and Artemis Cloud platforms which have demonstrated their relevance for multi-patient, multi-diagnosis and multi-stream temporal analysis in real-time for clinical management and research within Neonatal Intensive Care. Artemis and Artemis Cloud source data from a range of medical devices capable of transmission of the signal via wired or wireless connectivity and hence are well suited to process real-time data acquired from astronauts. A key benefit of this platform is its ability to monitor their health and wellbeing onboard the mission as well as enabling the astronaut's physiological data, and other clinical data, to be sent to the platform components at Mission Control at each stage when that communication is available. As a result, researchers at Mission Control would be able to simulate, deploy and tailor predictive analytics and diagnostics during the same spaceflight for - reater medical support.

STS-28 Columbia - Orbiter Vehicle (OV)-102 - Crew Insignia

NASA Image and Video Library

1988-10-11

S88-40309 (7 Nov. 1988) --- The STS-28 insignia was designed by the astronaut crew, who said it portrays the pride the American people have in their manned spaceflight program. It depicts America (the eagle) guiding the space program (the space shuttle) safely home from an orbital mission. The view looks south on Baja California and the west coast of the United States as the space travelers re-enter the atmosphere. The hypersonic contrails created by the eagle and shuttle represent the American flag. The crew called the simple boldness of the design symbolic of America's unfaltering commitment to leadership in the exploration and development of space. Crew members for STS-28 are astronauts Brewster H. Shaw Jr.,commander; Richard N. Richards, pilot; and David C. Leestma, Mark N. Brown and James C. Adamson, mission specialists. The NASA insignia design for space shuttle flights is reserved for use by the astronauts and for other official use as the NASA Administrator may authorize. Public availability has been approved only in the forms of illustrations by the various news media. When and if there is any change in this policy, which is not anticipated, the change will be publicly announced. Photo credit: NASA

Next Steps in the Evolution of Human Spaceflight Training

NASA Technical Reports Server (NTRS)

Balmain, Clint; Niemann, Chris; McGregor, Darrell

2011-01-01

Train before you fly has always been a watchword at NASA, and consequently, NASA has been conducting training for human spaceflight missions for longer than it has been involved in the actual conduct of human spaceflight missions. Throughout that time, NASA s approach to human spaceflight training has continuously evolved to keep pace with the technology of the modern world, but the approach to training itself has not changed significantly. Today, there are more tools and technologies that enable learning than ever before. This paper intends to review the challenges of human spaceflight training and how modern technology and an updated approach could improve that training. The Spaceflight Training Management Office (DA7) within the Mission Operations Directorate (MOD) has been investigating the current training of instructors, flight controllers and astronauts in order to identify where a new approach to training and training management may be necessary to improve the efficacy of the training provided. Through this investigation, the DA7 team has identified potential areas of improvement within International Space Station (ISS) training in a wide range of areas, including the delivery of training, the structure of the training program, the concept of what is considered training, and the management of that training. The ISS is an operational program with an established training paradigm. As such, the implementation of these concepts will be met with several challenges that may prevent or preclude them from being adopted. These challenges include demonstrating return-on-investment (ROI) and overcoming cultural or technological obstacles. This report will delve into the possible improvement areas for training, the future training concepts that are being considered, and the challenges associated with implementation. The paper will include concepts for utilization of Web 2.0 technologies, electronic learning, digital media, and other technologies in the development, management, and conduct of human spaceflight training.

Deep Space Test Bed for Radiation Studies

NASA Technical Reports Server (NTRS)

Adams, James H.; Christl, Mark; Watts, John; Kuznetsov, Eugene; Lin, Zi-Wei

2006-01-01

A key factor affecting the technical feasibility and cost of missions to Mars or the Moon is the need to protect the crew from ionizing radiation in space. Some analyses indicate that large amounts of spacecraft shielding may be necessary for crew safety. The shielding requirements are driven by the need to protect the crew from Galactic cosmic rays (GCR). Recent research activities aimed at enabling manned exploration have included shielding materials studies. A major goal of this research is to develop accurate radiation transport codes to calculate the shielding effectiveness of materials and to develop effective shielding strategies for spacecraft design. Validation of these models and calculations must be addressed in a relevant radiation environment to assure their technical readiness and accuracy. Test data obtained in the deep space radiation environment can provide definitive benchmarks and yield uncertainty estimates of the radiation transport codes. The two approaches presently used for code validation are ground based testing at particle accelerators and flight tests in high-inclination low-earth orbits provided by the shuttle, free-flyer platforms, or polar-orbiting satellites. These approaches have limitations in addressing all the radiation-shielding issues of deep space missions in both technical and practical areas. An approach based on long duration high altitude polar balloon flights provides exposure to the galactic cosmic ray composition and spectra encountered in deep space at a lower cost and with easier and more frequent access than afforded with spaceflight opportunities. This approach also results in shorter development times than spaceflight experiments, which is important for addressing changing program goals and requirements.

Sensors 2000! Program: Advanced Biosensor and Measurement Systems Technologies for Spaceflight Research and Concurrent, Earth-Based Applications

NASA Technical Reports Server (NTRS)

Hines, J.

1999-01-01

Sensors 2000! (S2K!) is a specialized, integrated projects team organized to provide focused, directed, advanced biosensor and bioinstrumentation systems technology support to NASA's spaceflight and ground-based research and development programs. Specific technology thrusts include telemetry-based sensor systems, chemical/ biological sensors, medical and physiological sensors, miniaturized instrumentation architectures, and data and signal processing systems. A concurrent objective is to promote the mutual use, application, and transition of developed technology by collaborating in academic-commercial-govemment leveraging, joint research, technology utilization and commercialization, and strategic partnering alliances. Sensors 2000! is organized around three primary program elements: Technology and Product Development, Technology infusion and Applications, and Collaborative Activities. Technology and Product Development involves development and demonstration of biosensor and biotelemetry systems for application to NASA Space Life Sciences Programs; production of fully certified spaceflight hardware and payload elements; and sensor/measurement systems development for NASA research and development activities. Technology Infusion and Applications provides technology and program agent support to identify available and applicable technologies from multiple sources for insertion into NASA's strategic enterprises and initiatives. Collaborative Activities involve leveraging of NASA technologies with those of other government agencies, academia, and industry to concurrently provide technology solutions and products of mutual benefit to participating members.

Spaceflight Causes Increased Virulence of Serratia Marcescens on a Drosophila Melanogaster Host

NASA Technical Reports Server (NTRS)

Bhattacharya, Sharmila; Wade, William; Clemens-Grisham, Rachel; Hosamani, Ravikumar; Bhardwaj, Shilpa R.; Lera, Matthew P.; Gresser, Amy L.

2015-01-01

Drosophila melanogaster, or the fruit fly, has long been an important organism for Earth-based research, and is now increasingly utilized as a model system to understand the biological effects of spaceflight. Studies in Drosophila melanogaster have shown altered immune responses in 3rd instar larvae and adult males following spaceflight, changes similar to those observed in astronauts. In addition, spaceflight has also been shown to affect bacterial physiology, as evidenced by studies describing altered virulence of Salmonella typhimurium following spaceflight and variation in biofilm growth patterns for the opportunistic pathogen Pseudomonas aeruginosa during flight. We recently sent Serratia marcescens Db11, a Drosophila pathogen and an opportunistic human pathogen, to the ISS on SpaceX-5 (Fruit Fly Lab-01). S. marcescens samples were stored at 4degC for 24 days on-orbit and then allowed to grow for 120 hours at ambient station temperature before being returned to Earth. Upon return, bacteria were isolated and preserved in 50% glycerol or RNAlater. Storage, growth, and isolation for ground control samples were performed using the same procedures. Spaceflight and ground samples stored in 50% glycerol were diluted and injected into 5-7-day-old ground-born adult D. melanogaster. Lethality was significantly greater in flies injected with the spaceflight samples compared to those injected with ground bacterial samples. These results indicate a shift in the virulence profile of the spaceflight S. marcescens Db11 and will be further assessed with molecular biological analyses. Our findings strengthen the conclusion that spaceflight impacts the virulence of bacterial pathogens on model host organisms such as the fruit fly. This research was supported by NASA's ISS Program Office (ISSPO) and Space Life and Physical Sciences Research and Applications (SLPSRA).

Fluid and electrolyte control in simulated and actual spaceflight

NASA Technical Reports Server (NTRS)

Leach, C. S.; Johnson, P. C., Jr.

1985-01-01

Effects of microgravity on body fluid distribution and electrolyte and hormonal levels of astronauts have been studied since the early manned space missions. Bedrested subjects have been used as controls to separate effects of microgravity from those of hypokinesia. These investigations have led to documentation of the physiological effects of spaceflight and to a unified theory of response to microgravity. During flight, crewmembers have decreased thirst and a net loss of body water, sodium, and potassium. These changes seem to be initiated by passive transfer of extracellular fluid resulting in increased central venous pressure (CVP), to which the homeostatic mechanisms respond. A new equilibrium state is maintained during flight; it does not change in response to negative calcium and nitrogen balances during flight. On reexposure to gravity, profound water and salt retention occurs to replete extracellular fluid. Attempts to avoid cardiac deconditioning by repleting water and salt before leaving microgravity have somewhat ameliorated postural hypotension but have had little effect on CVP, cardiac chamber size or electrolyte dynamics.

Man in space: The use of animal models

NASA Astrophysics Data System (ADS)

Ballard, Rodney W.; Souza, Kenneth A.

Animals have traditionally preceded man into space. During animal and human travels in space over the past almost 30 years, numerous anatomical, physiological, and biochemical changes have been observed. In order to safely qualify humans for extended duration space missions, scientific research needs to be performed. It may be possible to achieve many of these research goals with flight crews serving as experimental subjects; however, to do this with human subjects alone is impractical. Therefore, the use of animal surrogates as experimental subjects is essential to provide the missing information on the effects of spaceflights, to validate countermeasures, and to test medical treatment techniques which will be necessary for long duration missions. This research to assure human health, safety, and productivity in future extended duration space flights will include flights on NASA's Space Shuttle, unmanned biosatellites, and the Space Station Freedom.

Man in space: the use of animal models.

PubMed

Ballard, R W; Souza, K A

1991-01-01

Animals have traditionally preceded man into space. During animal and human travels in space over the past almost 30 years, numerous anatomical, physiological, and biochemical changes have been observed. In order to safely qualify humans for extended duration space missions, scientific research needs to be performed. It may be possible to achieve many of these research goals with flight crews serving as experimental subjects; however, to do this with human subjects alone is impractical. Therefore, the use of animal surrogates as experimental subjects is essential to provide the missing information on the effects of spaceflights, to validate countermeasures, and to test medical treatment techniques which will be necessary for long duration missions. This research to assure human health, safety, and productivity in future extended duration space flights will include flights on NASA's Space Shuttle, unmanned biosatellites, and the Space Station Freedom.

Evaluation of possible interaction among drugs contemplated for use during manned space flights

NASA Technical Reports Server (NTRS)

1973-01-01

Possible interactions among drugs contemplated for use during manned spaceflights have been studied in several animal species. The following seven drugs were investigated: nitrofurantoin, chloral hydrate, hexobarbital, phenobarbital, flurazepam, diphenoxylate, and phenazopyridine. Particular combinations included: chloral hydrate, hexabarbital or flurazepam with nitrofurantoin; phenobarbital or flurazepam with phenazopyridine; and diphenoxylate with two does formulations of nitrofurantoin. Studies were carried out in several species to determine whether induction of liver microsomal enzymes would increase the tendency of phenazopyridine to produce methemoglobin in vivo. Animals were premedicated with phenobarbital, a known inducer of azoreductase, and in a separate experiment with flurazepam, before administration of phenazopyridine. Methemoglobin production was determined in each animal after receiving phenazopyridine. No evidence was found for increased production of methemoglobin in the rat, dog, or rabbit that could be attributed to increased amounts of microsomal enzymes.

A digital communications system for manned spaceflight applications.

NASA Technical Reports Server (NTRS)

Batson, B. H.; Moorehead, R. W.

1973-01-01

A highly efficient, all-digital communications signal design employing convolutional coding and PN spectrum spreading is described for two-way transmission of voice and data between a manned spacecraft and ground. Variable-slope delta modulation is selected for analog/digital conversion of the voice signal, and a convolutional decoder utilizing the Viterbi decoding algorithm is selected for use at each receiving terminal. A PN spread spectrum technique is implemented to protect against multipath effects and to reduce the energy density (per unit bandwidth) impinging on the earth's surface to a value within the guidelines adopted by international agreement. Performance predictions are presented for transmission via a TDRS (tracking and data relay satellite) system and for direct transmission between the spacecraft and earth. Hardware estimates are provided for a flight-qualified communications system employing the coded digital signal design.

MIT January Operational Internship Experience 2011

NASA Technical Reports Server (NTRS)

DeLatte, Danielle; Furhmann, Adam; Habib, Manal; Joujon-Roche, Cecily; Opara, Nnaemeka; Pasterski, Sabrina Gonzalez; Powell, Christina; Wimmer, Andrew

2011-01-01

This slide presentation reviews the 2011 January Operational Internship experience (JOIE) program which allows students to study operational aspects of spaceflight, how design affects operations and systems engineering in practice for 3 weeks. Topics include: (1) Systems Engineering (2) NASA Organization (3) Workforce Core Values (4) Human Factors (5) Safety (6) Lean Engineering (7) NASA Now (8) Press, Media, and Outreach and (9) Future of Spaceflight.

Decision Making in Action

NASA Technical Reports Server (NTRS)

Orasanu, Judith; Statler, Irving C. (Technical Monitor)

1994-01-01

The importance of decision-making to safety in complex, dynamic environments like mission control centers and offshore installations has been well established. NASA-ARC has a program of research dedicated to fostering safe and effective decision-making in the manned spaceflight environment. Because access to spaceflight is limited, environments with similar characteristics, including aviation and nuclear power plants, serve as analogs from which space-relevant data can be gathered and theories developed. Analyses of aviation accidents cite crew judgement and decision making as causes or contributing factors in over half of all accidents. A similar observation has been made in nuclear power plants. Yet laboratory research on decision making has not proven especially helpful in improving the quality of decisions in these kinds of environments. One reason is that the traditional, analytic decision models are inappropriate to multidimensional, high-risk environments, and do not accurately describe what expert human decision makers do when they make decisions that have consequences. A new model of dynamic, naturalistic decision making is offered that may prove useful for improving decision making in complex, isolated, confined and high-risk environments. Based on analyses of crew performance in full-mission simulators and accident reports, features that define effective decision strategies in abnormal or emergency situations have been identified. These include accurate situation assessment (including time and risk assessment), appreciation of the complexity of the problem, sensitivity to constraints on the decision, timeliness of the response, and use of adequate information. More effective crews also manage their workload to provide themselves with time and resources to make good decisions. In brief, good decisions are appropriate to the demands of the situation. Effective crew decision making and overall performance are mediated by crew communication. Communication contributes to performance because it assures that all crew members have essential information, but it also regulates and coordinates crew actions and is the medium of collective thinking in response to a problem. This presentation will examine the relations between leadership, communication, decision making and overall crew performance. Implications of these findings for spaceflight and training for offshore installations will be discussed.

Decision Making in Action: Applying Research to Practice

NASA Technical Reports Server (NTRS)

Orasanu, Judith; Statler, Irving C. (Technical Monitor)

1994-01-01

The importance of decision-making to safety in complex, dynamic environments like mission control centers and offshore installations has been well established. NASA-ARC has a program of research dedicated to fostering safe and effective decision-making in the manned spaceflight environment. Because access to spaceflight is limited, environments with similar characteristics, including aviation and nuclear power plants, serve as analogs from which space-relevant data can be gathered and theories developed. Analyses of aviation accidents cite crew judgement and decision making as causes or contributing factors in over half of all accidents. A similar observation has been made in nuclear power plants. Yet laboratory research on decision making has not proven especially helpful in improving the quality of decisions in these kinds of environments. One reason is that the traditional, analytic decision models are inappropriate to multidimensional, high-risk environments, and do not accurately describe what expert human decision makers do when they make decisions that have consequences. A new model of dynamic, naturalistic decision making is offered that may prove useful for improving decision making in complex, isolated, confined and high-risk environments. Based on analyses of crew performance in full-mission simulators and accident reports, features that define effective decision strategies in abnormal or emergency situations have been identified. These include accurate situation assessment (including time and risk assessment), appreciation of the complexity of the problem, sensitivity to constraints on the decision, timeliness of the response, and use of adequate information. More effective crews also manage their workload to provide themselves with time and resources to make good decisions. In brief, good decisions are appropriate to the demands of the situation. Effective crew decision making and overall performance are mediated by crew communication. Communication contributes to performance because it assures that all crew members have essential information, but it also regulates and coordinates crew actions and is the medium of collective thinking in response to a problem. This presentation will examine the relations between leadership, communication, decision making and overall crew performance. Implications of these findings for spaceflight and training for offshore installations will be discussed.

Changes in the immune system during and after spaceflight

NASA Technical Reports Server (NTRS)

Taylor, G. R.; Konstantinova, I.; Sonnenfeld, G.; Jennings, R.

1997-01-01

The results of immunological analyses before, during and after spaceflight, have established the fact that spaceflight can result in a blunting of the immune mechanisms of human crew members and animal test species. There is some evidence that the immune function changes in short-term flights resemble those occurring after acute stress, while the changes during long-term flights resemble those caused by chronic stress. In addition, this blunting of the immune function occurs concomitant with a relative increase in potentially infectious microorganisms in the space cabin environment. This combination of events results in an increased probability of inflight infectious events. The realization of this probability has been shown to be partially negated by the judicious use of a preflight health stabilization program and other operational countermeasures. The continuation of these countermeasures, as well as microbial and immunological monitoring, are recommended for continued spaceflight safety.

Human spaceflight technology needs-a foundation for JSC's technology strategy

NASA Astrophysics Data System (ADS)

Stecklein, J. M.

Human space exploration has always been heavily influenced by goals to achieve a specific mission on a specific schedule. This approach drove rapid technology development, the rapidity of which added risks and became a major driver for costs and cost uncertainty. The National Aeronautics and Space Administration (NASA) is now approaching the extension of human presence throughout the solar system by balancing a proactive yet less schedule-driven development of technology with opportunistic scheduling of missions as the needed technologies are realized. This approach should provide cost effective, low risk technology development that will enable efficient and effective manned spaceflight missions. As a first step, the NASA Human Spaceflight Architecture Team (HAT) has identified a suite of critical technologies needed to support future manned missions across a range of destinations, including in cis-lunar space, near earth asteroid visits, lunar exploration, Mars moons, and Mars exploration. The challenge now is to develop a strategy and plan for technology development that efficiently enables these missions over a reasonable time period, without increasing technology development costs unnecessarily due to schedule pressure, and subsequently mitigating development and mission risks. NASA's Johnson Space Center (JSC), as the nation's primary center for human exploration, is addressing this challenge through an innovative approach in allocating Internal Research and Development funding to projects. The HAT Technology Needs (Tech Needs) Database has been developed to correlate across critical technologies and the NASA Office of Chief Technologist Technology Area Breakdown Structure (TABS). The TechNeeds Database illuminates that many critical technologies may support a single technical capability gap, that many HAT technology needs may map to a single TABS technology discipline, and that a single HAT technology need may map to multiple TABS technology disciplines. Th- TechNeeds Database greatly clarifies understanding of the complex relationships of critical technologies to mission and architecture element needs. Extensions to the core TechNeeds Database allow JSC to factor in and appropriately weight JSC core technology competencies, and considerations of commercialization potential and partnership potential. The inherent coupling among these, along with an appropriate importance weighting, has provided an initial prioritization for allocation of technology development research funding at JSc. The HAT Technology Needs Database, with a core of built-in reports, clarifies and communicates complex technology needs for cost effective human space exploration so that an organization seeking to assure that research prioritization supports human spaceflight of the future can be successful.

Human Spaceflight Technology Needs - A Foundation for JSC's Technology Strategy

NASA Technical Reports Server (NTRS)

Stecklein, Jonette M.

2013-01-01

Human space exploration has always been heavily influenced by goals to achieve a specific mission on a specific schedule. This approach drove rapid technology development, the rapidity of which adds risks as well as provides a major driver for costs and cost uncertainty. The National Aeronautics and Space Administration (NASA) is now approaching the extension of human presence throughout the solar system by balancing a proactive yet less schedule-driven development of technology with opportunistic scheduling of missions as the needed technologies are realized. This approach should provide cost effective, low risk technology development that will enable efficient and effective manned spaceflight missions. As a first step, the NASA Human Spaceflight Architecture Team (HAT) has identified a suite of critical technologies needed to support future manned missions across a range of destinations, including in cis-lunar space, near earth asteroid visits, lunar exploration, Mars moons, and Mars exploration. The challenge now is to develop a strategy and plan for technology development that efficiently enables these missions over a reasonable time period, without increasing technology development costs unnecessarily due to schedule pressure, and subsequently mitigating development and mission risks. NASA's Johnson Space Center (JSC), as the nation s primary center for human exploration, is addressing this challenge through an innovative approach in allocating Internal Research and Development funding to projects. The HAT Technology Needs (TechNeeds) Database has been developed to correlate across critical technologies and the NASA Office of Chief Technologist Technology Area Breakdown Structure (TABS). The TechNeeds Database illuminates that many critical technologies may support a single technical capability gap, that many HAT technology needs may map to a single TABS technology discipline, and that a single HAT technology need may map to multiple TABS technology disciplines. The TechNeeds Database greatly clarifies understanding of the complex relationships of critical technologies to mission and architecture element needs. Extensions to the core TechNeeds Database allow JSC to factor in and appropriately weight JSC Center Core Technology Competencies, and considerations of Commercialization Potential and Partnership Potential. The inherent coupling among these, along with an appropriate importance weighting, has provided an initial prioritization for allocation of technology development research funding for JSC. The HAT Technology Needs Database, with a core of built-in reports, clarifies and communicates complex technology needs for cost effective human space exploration such that an organization seeking to assure that research prioritization supports human spaceflight of the future can be successful.

A Delphi-Based Framework for systems architecting of in-orbit exploration infrastructure for human exploration beyond Low Earth Orbit

NASA Astrophysics Data System (ADS)

Aliakbargolkar, Alessandro; Crawley, Edward F.

2014-01-01

The current debate in the U.S. Human Spaceflight Program focuses on the development of the next generation of man-rated heavy lift launch vehicles. While launch vehicle systems are of critical importance for future exploration, a comprehensive analysis of the entire exploration infrastructure is required to avoid costly pitfalls at early stages of the design process. This paper addresses this need by presenting a Delphi-Based Systems Architecting Framework for integrated architectural analysis of future in-orbit infrastructure for human space exploration beyond Low Earth Orbit. The paper is structured in two parts. The first part consists of an expert elicitation study to identify objectives for the in-space transportation infrastructure. The study was conducted between November 2011 and January 2012 with 15 senior experts involved in human spaceflight in the United States and Europe. The elicitation study included the formation of three expert panels representing exploration, science, and policy stakeholders engaged in a 3-round Delphi study. The rationale behind the Delphi approach, as imported from social science research, is discussed. Finally, a novel version of the Delphi method is presented and applied to technical decision-making and systems architecting in the context of human space exploration. The second part of the paper describes a tradespace exploration study of in-orbit infrastructure coupled with a requirements definition exercise informed by expert elicitation. The uncertainties associated with technical requirements and stakeholder goals are explicitly considered in the analysis. The outcome of the expert elicitation process portrays an integrated view of perceived stakeholder needs within the human spaceflight community. Needs are subsequently converted into requirements and coupled to the system architectures of interest to analyze the correlation between exploration, science, and policy goals. Pareto analysis is used to identify architectures of interest for further consideration by decision-makers. The paper closes with a summary of insights and develops a strategy for evolutionary development of the exploration infrastructure of the incoming decades. The most important result produced by this analysis is the identification of a critical irreducible ambiguity undermining value delivery for the in-space transportation infrastructure of the next three decades: destination choice. Consensus on destination is far from being reached by the community at large, with particular reference to exploration and policy stakeholders. The realization of this ambiguity is a call for NASA to promote an open forum on this topic, and to develop a strong case for policy makers to incentivize investments in the human spaceflight industry in the next decades.

GEMINI-TITAN (GT)-10 - EARTH SKY - RENDEZVOUS - OUTER SPACE

NASA Image and Video Library

1966-07-18

S66-46122 (18 July 1966) --- Agena Target Docking Vehicle 5005 is photographed from the Gemini-Titan 10 (GT-10) spacecraft during rendezvous in space. The two spacecraft are about 38 feet apart. After docking with the Agena, astronauts John W. Young, command pilot, and Michael Collins, pilot, fired the 16,000 pound thrust engine of Agena X's primary propulsion system to boost the combined vehicles into an orbit with an apogee of 413 nautical miles to set a new altitude record for manned spaceflight. Photo credit: NASA

Mir hardware heritage

NASA Technical Reports Server (NTRS)

Portree, David S. F.

1995-01-01

The heritage of the major Mir complex hardware elements is described. These elements include Soyuz-TM and Progress-M; the Kvant, Kvant 2, and Kristall modules; and the Mir base block. Configuration changes and major mission events of the Salyut 6, Salyut 7, and Mir multiport space stations are described in detail for the period 1977-1994. A comparative chronology of U.S. and Soviet/Russian manned spaceflight is also given for that period. The 68 illustrations include comparative scale drawings of U.S. and Russian spacecraft as well as sequential drawings depicting missions and mission events.

Smoke Detection for the Orion Crew Exploration Vehicle

NASA Technical Reports Server (NTRS)

Sutin, Brian M.; Niu, William; Steiner, George; O'Hara, William; Lewis, John F.

2009-01-01

The Orion Crew Exploration Vehicle (CEV) requires a smoke detector for the detection of particulate smoke products as part of the Fire Detection and Suppression (FDS) system. The smoke detector described in this paper is an adaptation of a mature commercial aircraft design for manned spaceflight. Changes made to the original design include upgrading the materials and electronic to space-qualified parts, and modifying the mechanical design to withstand launch and landing loads. The results of laboratory characterization of the response of the new design to test particles are presented.

GEMINI-TITAN-8 - PRELAUNCH ACTIVITY

NASA Image and Video Library

1966-03-16

S66-24439 (16 March 1966) --- The Gemini-8 prime crew, along with several fellow astronauts, have a hearty breakfast of steak and eggs on the morning of the Gemini-8 launch. Seated clockwise around the table, starting at lower left, are Donald K. Slayton, Manned Spaceflight Center (MSC) Assistant Director for Flight Crew Operations; astronaut Neil A. Armstrong, Gemini-8 command pilot; scientist-astronaut F. Curtis Michel; astronaut R. Walter Cunningham; astronaut Alan B. Shepard Jr. (face obscured), Chief, MSC Astronaut Office; astronaut David R. Scott, Gemini-8 pilot; and astronaut Roger B. Chaffee. Photo credit: NASA

Medical qualification of a commercial spaceflight participant: not your average astronaut.

PubMed

Jennings, Richard T; Murphy, David M F; Ware, David L; Aunon, Serena M; Moon, Richard E; Bogomolov, Valery V; Morgun, Valeri V; Voronkov, Yuri I; Fife, Caroline E; Boyars, Michael C; Ernst, Randy D

2006-05-01

Candidates for commercial spaceflight may be older than the typical astronaut and more likely to have medical problems that place them at risk during flight. Since the effects of microgravity on many medical conditions are unknown, physicians have little guidance when evaluating and certifying commercial spaceflight participants. This dynamic new era in space exploration may provide important data for evaluating medical conditions, creating appropriate medical standards, and optimizing treatment alternatives for long-duration spaceflight. A 57-yr-old spaceflight participant for an ISS mission presented with medical conditions that included moderately severe bullous emphysema, previous spontaneous pneumothorax with talc pleurodesis, a lung parenchymal mass, and ventricular and atrial ectopy. The medical evaluation required for certification was extensive and included medical studies and monitoring conducted in analogue spaceflight environments including altitude chambers, high altitude mixed-gas simulation, zero-G aircraft, and high-G centrifuge. To prevent recurrence of pneumothorax, we performed video-assisted thoracoscopic pleurodesis, and to assess lung masses, several percutaneous or direct biopsies. The candidate's 10-d mission was without incident. Non-career astronauts applying for commercial suborbital and orbital spaceflight will, at least in the near future, challenge aerospace physicians with unknowns regarding safety during training and flight, and highlight important ethical and risk-assessment problems. The information obtained from this new group of space travelers will provide important data for the evaluation and in-flight treatment of medical problems that space programs have not yet addressed systematically, and may improve the medical preparedness of exploration-class missions.

Digital Imaging Star Camera

DTIC Science & Technology

2009-09-30

NRL Code 8221) is the Lead Thermal Engineer for heater and blanket design for the mission. WORK COMPLETED The program developed a briefing...development of such science-enabling technology is critical for space-flight mission on small spacecraft , such as CubeSats, that cannot afford the mass, power...critical for space-flight mission on small spacecraft , such as CubeSats, that cannot afford the mass, power or cost of traditional star trackers but

Experiment M115: Special hematologic effects: Dynamic changes in red cell shape in response to the space-flight environment

NASA Technical Reports Server (NTRS)

Kimzey, S. L.; Burns, L. C.; Fischer, C. L.

1974-01-01

The significance of the transformations in red cell shape observed during the Skylab study must be considered relative to the limitation of man's participation in extended space flight missions. The results of this one study are not conclusive with respect to this question. Based on these examinations of red cells in normal, healthy men and based on other Skylab experiment data relative to the functional capacity of the red cells in vitro and the performance capacity of man as an integrated system, the changes observed would not appear to be the limiting factor in determining man's stay in space. However, the results of this experiment and the documented red cell mass loss during space flight raise serious questions at this time relative to the selection criteria utilized for passengers and crews of future space flights. Until the specific cause and impact of the red cell shape change on cell survival in vivo can be resolved, individuals with diagnosed hematologic abnormalities should not be considered as prime candidates for missions, especially those of longer duration.

JSC Design and Procedural Standards, JSC-STD-8080

NASA Technical Reports Server (NTRS)

Punch, Danny T.

2011-01-01

This document provides design and procedural requirements appropriate for inclusion in specifications for any human spaceflight program, project, spacecraft, system, or end item. The term "spacecraft" as used in the standards includes launch vehicles, orbital vehicles, non-terrestrial surface vehicles, and modules. The standards are developed and maintained as directed by Johnson Space Center (JSC) Policy Directive JPD 8080.2, JSC Design and Procedural Standards for Human Space Flight Equipment. The Design and Procedural Standards contained in this manual represent human spacecraft design and operational knowledge applicable to a wide range of spaceflight activities. These standards are imposed on JSC human spaceflight equipment through JPD 8080.2. Designers shall comply with all design standards applicable to their design effort.

Physical Training for Long-Duration Spaceflight.

PubMed

Loehr, James A; Guilliams, Mark E; Petersen, Nora; Hirsch, Natalie; Kawashima, Shino; Ohshima, Hiroshi

2015-12-01

Physical training has been conducted on the International Space Station (ISS) for the past 10 yr as a countermeasure to physiological deconditioning during spaceflight. Each member space agency has developed its own approach to creating and implementing physical training protocols for their astronauts. We have divided physical training into three distinct phases (preflight, in-flight, and postflight) and provided a description of each phase with its constraints and limitations. We also discuss how each member agency (NASA, ESA, CSA, and JAXA) prescribed physical training for their crewmembers during the first 10 yr of ISS operations. It is important to understand the operational environment, the agency responsible for the physical training program, and the constraints and limitations associated with spaceflight to accurately design and implement exercise training or interpret the exercise data collected on ISS. As exploration missions move forward, resolving agency differences in physical training programs will become important to maximizing the effectiveness of exercise as a countermeasure and minimizing any mission impacts.

Spaceflight Activates Autophagy Programs and the Proteasome in Mouse Liver

PubMed Central

Blaber, Elizabeth A.; Pecaut, Michael J.

2017-01-01

Increased oxidative stress is an unavoidable consequence of exposure to the space environment. Our previous studies showed that mice exposed to space for 13.5 days had decreased glutathione levels, suggesting impairments in oxidative defense. Here we performed unbiased, unsupervised and integrated multi-‘omic analyses of metabolomic and transcriptomic datasets from mice flown aboard the Space Shuttle Atlantis. Enrichment analyses of metabolite and gene sets showed significant changes in osmolyte concentrations and pathways related to glycerophospholipid and sphingolipid metabolism, likely consequences of relative dehydration of the spaceflight mice. However, we also found increased enrichment of aminoacyl-tRNA biosynthesis and purine metabolic pathways, concomitant with enrichment of genes associated with autophagy and the ubiquitin-proteasome. When taken together with a downregulation in nuclear factor (erythroid-derived 2)-like 2-mediated signaling, our analyses suggest that decreased hepatic oxidative defense may lead to aberrant tRNA post-translational processing, induction of degradation programs and senescence-associated mitochondrial dysfunction in response to the spaceflight environment. PMID:28953266

Spaceflight Activates Autophagy Programs and the Proteasome in Mouse Liver.

PubMed

Blaber, Elizabeth A; Pecaut, Michael J; Jonscher, Karen R

2017-09-27

Increased oxidative stress is an unavoidable consequence of exposure to the space environment. Our previous studies showed that mice exposed to space for 13.5 days had decreased glutathione levels, suggesting impairments in oxidative defense. Here we performed unbiased, unsupervised and integrated multi-'omic analyses of metabolomic and transcriptomic datasets from mice flown aboard the Space Shuttle Atlantis. Enrichment analyses of metabolite and gene sets showed significant changes in osmolyte concentrations and pathways related to glycerophospholipid and sphingolipid metabolism, likely consequences of relative dehydration of the spaceflight mice. However, we also found increased enrichment of aminoacyl-tRNA biosynthesis and purine metabolic pathways, concomitant with enrichment of genes associated with autophagy and the ubiquitin-proteasome. When taken together with a downregulation in nuclear factor (erythroid-derived 2)-like 2-mediated signaling, our analyses suggest that decreased hepatic oxidative defense may lead to aberrant tRNA post-translational processing, induction of degradation programs and senescence-associated mitochondrial dysfunction in response to the spaceflight environment.

Risk Management Structured for Today's Environment

NASA Technical Reports Server (NTRS)

Greenfield, Michael A.

1998-01-01

In NPG (NASA Procedures and Guidelines) 7120.5A, we define risk management as "an organized, systematic decision-making process that efficiently identifies, analyzes, plans, tracks, controls, and communicates and documents risk in order to increase the likelihood of achieving program/project goals." Effective risk management depends upon a thorough understanding of the concept of risk, the principles of risk management and the formation of a disciplined risk management process. In human spaceflight programs, NASA has always maintained a rigorous and highly structured risk management effort. When lives are at stake, NASA's missions must be 100% safe; the risk management approach used in human spaceflight has always been comprehensive.

KSC-108-75P-0057

NASA Image and Video Library

1975-02-10

CAPE CANAVERAL, Fla. – The Soviet and American crews for the July Apollo Soyuz Test Project [standing, center] addressed personnel assembled in a firing room at KSC on February 10. The crews for the joint manned space mission toured the Center during their three-day visit which also included inspection of ASTP equipment and facilities and a trip to Disney World. The first international crewed spaceflight was a joint U.S.-U.S.S.R. rendezvous and docking mission. The Apollo-Soyuz Test Project, or ASTP, took its name from the spacecraft employed: the American Apollo and the Soviet Soyuz. The three-man Apollo crew lifted off from Kennedy Space Center aboard a Saturn IB rocket on July 15, 1975, to link up with the Soyuz that had launched a few hours earlier. A cylindrical docking module served as an airlock between the two spacecraft for transfer of the crew members. Photo credit: NASA

Control mechanisms of circadian rhythms in body composition: Implications for manned spaceflight

NASA Technical Reports Server (NTRS)

Ede, M. C. M.

1975-01-01

The mechanisms that underlie the circadian variations in electrolyte content in body fluid compartments were investigated, and the mechanisms that control the oscillations were studied in order to investigate what effects internal desynchronization in such a system would have during manned space flight. The studies were performed using volunteer human subjects and squirrel monkeys. The intercompartmental distribution of potassium was examined when dietary intake, activity, and posture are held constant throughout each 24-hour day. A net flux of potassium was observed out of the body cell mass during the day and a reverse flux from the extracellular fluid into the body cell mass during the night, counterbalanced by changes in urinary potassium excretion. Experiments with monkeys provided evidence for the synchronization of renal potassium excretion by the rhythm of cortisol secretion with the light-dark cycle. Three models of the circadian timing system were formalized.

Estimating the Reliability of a Soyuz Spacecraft Mission

NASA Technical Reports Server (NTRS)

Lutomski, Michael G.; Farnham, Steven J., II; Grant, Warren C.

2010-01-01

Once the US Space Shuttle retires in 2010, the Russian Soyuz Launcher and Soyuz Spacecraft will comprise the only means for crew transportation to and from the International Space Station (ISS). The U.S. Government and NASA have contracted for crew transportation services to the ISS with Russia. The resulting implications for the US space program including issues such as astronaut safety must be carefully considered. Are the astronauts and cosmonauts safer on the Soyuz than the Space Shuttle system? Is the Soyuz launch system more robust than the Space Shuttle? Is it safer to continue to fly the 30 year old Shuttle fleet for crew transportation and cargo resupply than the Soyuz? Should we extend the life of the Shuttle Program? How does the development of the Orion/Ares crew transportation system affect these decisions? The Soyuz launcher has been in operation for over 40 years. There have been only two loss of life incidents and two loss of mission incidents. Given that the most recent incident took place in 1983, how do we determine current reliability of the system? Do failures of unmanned Soyuz rockets impact the reliability of the currently operational man-rated launcher? Does the Soyuz exhibit characteristics that demonstrate reliability growth and how would that be reflected in future estimates of success? NASA s next manned rocket and spacecraft development project is currently underway. Though the projects ultimate goal is to return to the Moon and then to Mars, the launch vehicle and spacecraft s first mission will be for crew transportation to and from the ISS. The reliability targets are currently several times higher than the Shuttle and possibly even the Soyuz. Can these targets be compared to the reliability of the Soyuz to determine whether they are realistic and achievable? To help answer these questions this paper will explore how to estimate the reliability of the Soyuz Launcher/Spacecraft system, compare it to the Space Shuttle, and its potential impacts for the future of manned spaceflight. Specifically it will look at estimating the Loss of Mission (LOM) probability using historical data, reliability growth, and Probabilistic Risk Assessment techniques

A simulation based optimization approach to model and design life support systems for manned space missions

NASA Astrophysics Data System (ADS)

Aydogan, Selen

This dissertation considers the problem of process synthesis and design of life-support systems for manned space missions. A life-support system is a set of technologies to support human life for short and long-term spaceflights, via providing the basic life-support elements, such as oxygen, potable water, and food. The design of the system needs to meet the crewmember demand for the basic life-support elements (products of the system) and it must process the loads generated by the crewmembers. The system is subject to a myriad of uncertainties because most of the technologies involved are still under development. The result is high levels of uncertainties in the estimates of the model parameters, such as recovery rates or process efficiencies. Moreover, due to the high recycle rates within the system, the uncertainties are amplified and propagated within the system, resulting in a complex problem. In this dissertation, two algorithms have been successfully developed to help making design decisions for life-support systems. The algorithms utilize a simulation-based optimization approach that combines a stochastic discrete-event simulation and a deterministic mathematical programming approach to generate multiple, unique realizations of the controlled evolution of the system. The timelines are analyzed using time series data mining techniques and statistical tools to determine the necessary technologies, their deployment schedules and capacities, and the necessary basic life-support element amounts to support crew life and activities for the mission duration.

Integrated Immune

NASA Technical Reports Server (NTRS)

Crucian, Brian; Mehta, Satish; Stowe, Raymond; Uchakin, Peter; Quiriarte, Heather; Pierson, Duane; Sams, Clarnece

2010-01-01

This slide presentation reviews the program to replace several recent studies about astronaut immune systems with one comprehensive study that will include in-flight sampling. The study will address lack of in-flight data to determine the inflight status of immune systems, physiological stress, viral immunity, to determine the clinical risk related to immune dysregulation for exploration class spaceflight, and to determine the appropriate monitoring strategy for spaceflight-associated immune dysfunction, that could be used for the evaluation of countermeasures.

Crosscutting Development- EVA Tools and Geology Sample Acquisition

NASA Technical Reports Server (NTRS)

2011-01-01

Exploration to all destinations has at one time or another involved the acquisition and return of samples and context data. Gathered at the summit of the highest mountain, the floor of the deepest sea, or the ice of a polar surface, samples and their value (both scientific and symbolic) have been a mainstay of Earthly exploration. In manned spaceflight exploration, the gathering of samples and their contextual information has continued. With the extension of collecting activities to spaceflight destinations comes the need for geology tools and equipment uniquely designed for use by suited crew members in radically different environments from conventional field geology. Beginning with the first Apollo Lunar Surface Extravehicular Activity (EVA), EVA Geology Tools were successfully used to enable the exploration and scientific sample gathering objectives of the lunar crew members. These early designs were a step in the evolution of Field Geology equipment, and the evolution continues today. Contemporary efforts seek to build upon and extend the knowledge gained in not only the Apollo program but a wealth of terrestrial field geology methods and hardware that have continued to evolve since the last lunar surface EVA. This paper is presented with intentional focus on documenting the continuing evolution and growing body of knowledge for both engineering and science team members seeking to further the development of EVA Geology. Recent engineering development and field testing efforts of EVA Geology equipment for surface EVA applications are presented, including the 2010 Desert Research and Technology Studies (Desert RATs) field trial. An executive summary of findings will also be presented, detailing efforts recommended for exotic sample acquisition and pre-return curation development regardless of planetary or microgravity destination.

Dynamics of storage reserve deposition during Brassica rapa L. pollen and seed development in microgravity

NASA Technical Reports Server (NTRS)

Kuang, A.; Popova, A.; McClure, G.; Musgrave, M. E.

2005-01-01

Pollen and seeds share a developmental sequence characterized by intense metabolic activity during reserve deposition before drying to a cryptobiotic form. Neither pollen nor seed development has been well studied in the absence of gravity, despite the importance of these structures in supporting future long-duration manned habitation away from Earth. Using immature seeds (3-15 d postpollination) of Brassica rapa L. cv. Astroplants produced on the STS-87 flight of the space shuttle Columbia, we compared the progress of storage reserve deposition in cotyledon cells during early stages of seed development. Brassica pollen development was studied in flowers produced on plants grown entirely in microgravity on the Mir space station and fixed while on orbit. Cytochemical localization of storage reserves showed differences in starch accumulation between spaceflight and ground control plants in interior layers of the developing seed coat as early as 9 d after pollination. At this age, the embryo is in the cotyledon elongation stage, and there are numerous starch grains in the cotyledon cells in both flight and ground control seeds. In the spaceflight seeds, starch was retained after this stage, while starch grains decreased in size in the ground control seeds. Large and well-developed protein bodies were observed in cotyledon cells of ground control seeds at 15 d postpollination, but their development was delayed in the seeds produced during spaceflight. Like the developing cotyledonary tissues, cells of the anther wall and filaments from the spaceflight plants contained numerous large starch grains, while these were rarely seen in the ground controls. The tapetum remained swollen and persisted to a later developmental stage in the spaceflight plants than in the ground controls, even though most pollen grains appeared normal. These developmental markers indicate that Brassica seeds and pollen produced in microgravity were physiologically younger than those produced in 1 g. We hypothesize that microgravity limits mixing of the gaseous microenvironments inside the closed tissues and that the resulting gas composition surrounding the seeds and pollen retards their development.

Risk of Cardiac Rhythm Problems During Spaceflight

NASA Technical Reports Server (NTRS)

Lee, Stuart M. C.; Stenger, Michael B.; Laurie, Steven S.; Macias, Brandon R.

2017-01-01

NASA has concerns regarding the incidence and clinical significance of cardiac arrhythmias that could occur during long-term exposure to the spaceflight environment, such as on the International Space Station (ISS) or during a prolonged (e.g., up to 3 years) sojourn to Mars or on the Moon. There have been some anecdotal reports and a few documented cases of cardiac arrhythmias in space, including one documented episode of non-sustained ventricular tachycardia. The potential catastrophic nature of a sudden cardiac death in the remote space environment has led to concerns from the early days of the space program that spaceflight might be arrhythmogenic. Indeed, there are known and well-defined changes in the cardiovascular system with spaceflight: a) plasma volume is reduced, b) left ventricular mass is decreased, and c) the autonomic nervous system adapts to the weightless environment. Combined, these physiologic adaptations suggest that changes in cardiac structure and neuro-humoral environment during spaceflight could alter electrical conduction, although the evidence supporting this contention consists mostly of minor changes in QT interval (the time between the start of the Q wave and the end of the T wave on an electrocardiogram tracing) in a small number of astronauts after long-duration spaceflight. Concurrent with efforts by NASA Medical Operations to refine and improve screening techniques relevant to arrhythmias and cardiovascular disease, as NASA enters the era of exploration-class missions it will be critical to determine with the highest degree of certainty whether spaceflight by itself alters cardiac structure and function sufficiently to increase the risk of arrhythmias.

Apollo 11 Mission Commemorated

NASA Astrophysics Data System (ADS)

Showstack, Randy

2009-07-01

On 24 July 1969, 4 days after Apollo 11 Mission Commander Neil Armstrong and Lunar Module Eagle Pilot Eugene “Buzz” Aldrin had become the first people to walk on the Moon, they and Apollo 11 Command Module Pilot Michael Collins peered through a window of the Mobile Quarantine Facility on board the U.S.S. Hornet following splashdown of the command module in the central Pacific as U.S. President Richard Nixon told them, “This is the greatest week in the history of the world since the creation.” Forty years later, the Apollo 11 crew and other Apollo-era astronauts gathered at several events in Washington, D. C., to commemorate and reflect on the Apollo program, that mission, and the future of manned spaceflight. “I don’t know what the greatest week in history is,” Aldrin told Eos. “But it was certainly a pioneering opening the door. With the door open when we touched down on the Moon, that was what enabled humans to put many more footprints on the surface of the Moon.”

Multicultural Ground Teams in Space Programs

NASA Astrophysics Data System (ADS)

Maier, M.

2012-01-01

In the early years of space flight only two countries had access to space. In the last twenty years, there have been major changes in how we conduct space business. With the fall of the iron curtain and the growing of the European Union, more and more players were able to join the space business and space science. By end of the last century, numerous countries, agencies and companies earned the right to be equal partners in space projects. This paper investigates the impact of multicultural teams in the space arena. Fortunately, in manned spaceflight, especially for long duration missions, there are several studies and simulations reporting on multicultural team impact. These data have not been as well explored on the team interactions within the ground crews. The focus of this paper are the teams working on the ISS project. Hypotheses will be drawn from the results of space crew research to determine parallels and differences for this vital segment of success in space missions. The key source of the data will be drawn from structured interviews with managers and other ground crews on the ISS project.

Life Sciences Division Spaceflight Hardware

NASA Technical Reports Server (NTRS)

Yost, B.

1999-01-01

The Ames Research Center (ARC) is responsible for the development, integration, and operation of non-human life sciences payloads in support of NASA's Gravitational Biology and Ecology (GB&E) program. To help stimulate discussion and interest in the development and application of novel technologies for incorporation within non-human life sciences experiment systems, three hardware system models will be displayed with associated graphics/text explanations. First, an Animal Enclosure Model (AEM) will be shown to communicate the nature and types of constraints physiological researchers must deal with during manned space flight experiments using rodent specimens. Second, a model of the Modular Cultivation System (MCS) under development by ESA will be presented to highlight technologies that may benefit cell-based research, including advanced imaging technologies. Finally, subsystems of the Cell Culture Unit (CCU) in development by ARC will also be shown. A discussion will be provided on candidate technology requirements in the areas of specimen environmental control, biotelemetry, telescience and telerobotics, and in situ analytical techniques and imaging. In addition, an overview of the Center for Gravitational Biology Research facilities will be provided.

NASA Headquarters Space Operations Center: Providing Situational Awareness for Spaceflight Contingency Response

NASA Technical Reports Server (NTRS)

Maxwell, Theresa G.; Bihner, William J.

2010-01-01

This paper discusses the NASA Headquarters mishap response process for the Space Shuttle and International Space Station programs, and how the process has evolved based on lessons learned from the Space Shuttle Challenger and Columbia accidents. It also describes the NASA Headquarters Space Operations Center (SOC) and its special role in facilitating senior management's overall situational awareness of critical spaceflight operations, before, during, and after a mishap, to ensure a timely and effective contingency response.

The influence of space flight on erythrokinetics in man. Space Life Sciences Missions 1 and 2. Experiment E261

NASA Technical Reports Server (NTRS)

Alfrey, Clarence P.

1995-01-01

The purpose of this contract was to design and conduct experiments that would increase our understanding of the influence of space flight on erythrokinetics and the rapid change that occurs in the red blood cell mass during spaceflight. The experiment designated E261, was flown on Space Life Science missions SLS-1 and SLS-2 (STS 40 and STS 58). Unique features of this experiment included radionuclide tracer studies during flight and frequent in-flight blood samples specifically for the first three or four days of the mission. Plasma volume measurements were made early and late in the missions. Radioactive iron kinetics studies were initiated after one or three days in microgravity since the magnitude of the red blood cell mass decrease dictated that bone marrow production must be decreased very early in the flight. The schedule was designed to study the time course of the changes that occur during spaceflight and to possibly define a mechanism for the rapid reduction in red blood cell mass.

Microgels for long-term storage of vitamins for extended spaceflight

NASA Astrophysics Data System (ADS)

Schroeder, R.

2018-02-01

Biocompatible materials that can encapsulate large amounts of nutrients while protecting them from degrading environmental influences are highly desired for extended manned spaceflight. In this study, alkaline-degradable microgels based on poly(N-vinylcaprolactam) (PVCL) were prepared and analysed with their regard to stabilise retinol which acts as a model vitamin (vitamin A1). It was investigated whether the secondary crosslinking of the particles with a polyphenol can prevent the isomerisation of biologically active all-trans retinol to biologically inactive cis-trans retinol. Both loading with retinol and secondary crosslinking of the particles was performed at room temperature to prevent an early degradation of the vitamin. This study showed that PVCL microgels drastically improve the water solubility of hydrophobic retinol. Additionally, it is demonstrated that the highly crosslinked microgel particles in aqueous solution can be utilised to greatly retard the light- and temperature-induced isomerisation process of retinol by a factor of almost 100 compared to pure retinol stored in ethanol. The use of microgels offers various advantages over other drug delivery systems as they exhibit enhanced biocompatibility and superior aqueous solubility.

On Orbit Osteobiology Experiments: from "STROMA" to "MDS" -from in vitro to in vivo

NASA Astrophysics Data System (ADS)

Liu, Yi; Cancedda, Ranieri

Spaceflight causes profound changes in the skeleton, in particular, in the weight-loading bones. Uncoupling of bone remodeling equilibrium between bone formation and resorption is con-sidered responsible for the microgravity-induced bone loss. These changes result in weak-ened and brittle bones prone to fracture on re-entry and in accelerated osteoporosis, making bone deterioration a major problem obstructing the prospects of long-duration manned space flight. Osteoblasts (bone forming cells) and osteocytes (bone resorption cells) are known to be mechano-sensors. Short-exposure of osteoblasts to simulated microgravity ensnarled cell adhe-sion and cytoskeleton. Also osteoblast precursors such as bone marrow stroma cells (BMSC) were shown to be sensitive to mechanical loading. We performed a series of STROMA space-flight experiments by culturing BMSC or co-culturing osteoblasts and osteoclast precursors in automated bioreactors on orbit. Genechip analysis revealed an inhibition of cell proliferation and an unexpected activation of nervous system development genes by spaceflight. To unravel effects of microgravity on genes governing bone mass, transgenic mice with a higher bone mass were flown to orbit inside the Mice Drawer System (MDS) payload. The MDS experiment was launched inside Shuttle Discovery in STS-128 on August 28 2009 at 23:58 EST, and returned to earth by Shuttle Atlantis in STS129 on November 27 2009 at 9:47 EST, marking it as the first long duration animal experiment on the International Space Station (ISS).

Flight Planning and Procedures

NASA Technical Reports Server (NTRS)

Rich, Allison C.

2016-01-01

The National Aeronautics and Space Administration (NASA) was founded in 1958 by President Eisenhower as a civilian lead United States federal agency designed to advance the science of space. Over the years, NASA has grown with a vision to "reach for new heights and reveal the unknown for the benefit of humankind" (About NASA). Mercury, Gemini, Apollo, Skylab, and Space Shuttle are just a few of the programs that NASA has led to advance our understanding of the universe. Each of the eleven main NASA space centers located across the United States plays a unique role in accomplishing that vision. Since 1961, Johnson Space Center (JSC) has led the effort for manned spaceflight missions. JSC has a mission to "provide and apply the preeminent capabilities to develop, operate, and integrate human exploration missions spanning commercial, academic, international, and US government partners" (Co-op Orientation). To do that, JSC is currently focused on two main programs, Orion and the International Space Station (ISS). Orion is the exploration vehicle that will take astronauts to Mars; a vessel comparable to the Apollo capsule. The International Space Station (ISS) is a space research facility designed to expand our knowledge of science in microgravity. The first piece of the ISS was launched in November of 1998 and has been in a continuous low earth orbit ever since. Recently, two sub-programs have been developed to resupply the ISS. The Commercial Cargo program is currently flying cargo and payloads to the ISS; the Commercial Crew program will begin flying astronauts to the ISS in a few years.

Report of the Space Shuttle Management Independent Review Team

NASA Technical Reports Server (NTRS)

1995-01-01

At the request of the NASA Administrator a team was formed to review the Space Shuttle Program and propose a new management system that could significantly reduce operating costs. Composed of a group of people with broad and extensive experience in spaceflight and related areas, the team received briefings from the NASA organizations and most of the supporting contractors involved in the Shuttle Program. In addition, a number of chief executives from the supporting contractors provided advice and suggestions. The team found that the present management system has functioned reasonably well despite its diffuse structure. The team also determined that the shuttle has become a mature and reliable system, and--in terms of a manned rocket-propelled space launch system--is about as safe as today's technology will provide. In addition, NASA has reduced shuttle operating costs by about 25 percent over the past 3 years. The program, however, remains in a quasi-development mode and yearly costs remain higher than required. Given the current NASA-contractor structure and incentives, it is difficult to establish cost reduction as a primary goal and implement changes to achieve efficiencies. As a result, the team sought to create a management structure and associated environment that enables and motivates the Program to further reduce operational costs. Accordingly, the review team concluded that the NASA Space Shuttle Program should (1) establish a clear set of program goals, placing a greater emphasis on cost-efficient operations and user-friendly payload integration; (2) redefine the management structure, separating development and operations and disengaging NASA from the daily operation of the space shuttle; and (3) provide the necessary environment and conditions within the program to pursue these goals.

Report of the Space Shuttle Management Independent Review Team

NASA Astrophysics Data System (ADS)

1995-02-01

At the request of the NASA Administrator a team was formed to review the Space Shuttle Program and propose a new management system that could significantly reduce operating costs. Composed of a group of people with broad and extensive experience in spaceflight and related areas, the team received briefings from the NASA organizations and most of the supporting contractors involved in the Shuttle Program. In addition, a number of chief executives from the supporting contractors provided advice and suggestions. The team found that the present management system has functioned reasonably well despite its diffuse structure. The team also determined that the shuttle has become a mature and reliable system, and--in terms of a manned rocket-propelled space launch system--is about as safe as today's technology will provide. In addition, NASA has reduced shuttle operating costs by about 25 percent over the past 3 years. The program, however, remains in a quasi-development mode and yearly costs remain higher than required. Given the current NASA-contractor structure and incentives, it is difficult to establish cost reduction as a primary goal and implement changes to achieve efficiencies. As a result, the team sought to create a management structure and associated environment that enables and motivates the Program to further reduce operational costs. Accordingly, the review team concluded that the NASA Space Shuttle Program should (1) establish a clear set of program goals, placing a greater emphasis on cost-efficient operations and user-friendly payload integration; (2) redefine the management structure, separating development and operations and disengaging NASA from the daily operation of the space shuttle; and (3) provide the necessary environment and conditions within the program to pursue these goals.

KSC-2012-1866

NASA Image and Video Library

2012-02-17

Apollo-Soyuz Test Project: The first international crewed spaceflight was a joint U.S.-U.S.S.R. rendezvous and docking mission. The Apollo-Soyuz Test Project, or ASTP, took its name from the spacecraft employed: the American Apollo and the Soviet Soyuz. The three-man Apollo crew lifted off from Kennedy Space Center aboard a Saturn IB rocket on July 15, 1975, to link up with the Soyuz that had launched a few hours earlier. A cylindrical docking module served as an airlock between the two spacecraft for transfer of the crew members. Poster designed by Kennedy Space Center Graphics Department/Greg Lee. Credit: NASA

Properties of 5052 Aluminum For Use as Honeycomb Core in Manned Spaceflight

NASA Technical Reports Server (NTRS)

Lerch, Bradley A.

2018-01-01

This work explains that the properties of Al 5052 material used commonly for honeycomb cores in sandwich panels are highly dependent on the tempering condition. It has not been common to specify the temper when ordering HC material nor is it common for the supplier to state what the temper is. For aerospace uses, a temper of H38 or H39 is probably recommended. This temper should be stated in the bill of material and should be verified upon receipt of the core. To this end some properties provided herein can aid as benchmark values.

Research on keyword retrieval method of HBase database based on index structure

NASA Astrophysics Data System (ADS)

Gong, Pijin; Lv, Congmin; Gong, Yongsheng; Ma, Haozhi; Sun, Yang; Wang, Lu

2017-10-01

With the rapid development of manned spaceflight engineering, the scientific experimental data in space application system is increasing rapidly. How to efficiently query the specific data in the mass data volume has become a problem. In this paper, a method of retrieving the object data based on the object attribute as the keyword is proposed. The HBase database is used to store the object data and object attributes, and the secondary index is constructed. The research shows that this method is a good way to retrieve specified data based on object attributes.

Biorhythms and space experiments with nonhuman primates

NASA Technical Reports Server (NTRS)

Winget, C. M.

1977-01-01

Man's response to exposure to spaceflight and weightlessness is expressed in physiological adjustments which involve his health and ability to function. The amplitude and periodicity of fluctuations in biological processes affect various functions and responses to provocative stimuli. Primates and other species are subjected to tests to determine the consequences of an altered biorhythm on work and performance, emotional stability, biomedical evaluation in space, the ability to cope with the unexpected, and susceptibility to infection, toxicity, radiation, drugs, and stress. Factors in the environment or operational setup which can change the physiological baseline must be determined and controlled.

COSMOS 2044 Mission: Overview

NASA Technical Reports Server (NTRS)

Grindeland, R. E.; Ballard, R. W.; Connol, J. P.; Vasques, M. F.

1992-01-01

The COSMOS 2044 spaceflight was the ninth Soviet-International joint mission dedicated to space biomedicine and the seventh in which the United States has participated. The unmanned Vostok vehicle carried 10 rats and two rhesus monkeys on its 14-day voyage. This spaceflight yielded an unprecedented bounty of data on physiological responses to the microgravity environment. The tissues studied and the numbers and types of studies performed by members of the international science community constituted a new record. Many of the results obtained by the approximately 80 American scientists who participated are reported in the series of COSMOS 2044 papers in this issue. Descriptions of the spaceflight and animal procedures are detailed elsewhere. The broad goals of the space biomedical program are threefold. The first is to characterize qualitatively and quantitatively the biological responses to the microgravity environment, be they adaptive or pathological. The second goal is to clarify the physiological-biochemical mechanisms mediating the responses to microgravity. The third goal of this program is to use the space environment as a tool to better understand adaptive and disease processes in terrestrial organisms.

Concepts for a NASA Applied Spaceflight Environments Office

NASA Technical Reports Server (NTRS)

Edwards, David L.; Burns, Howard D.; Xapsos, Michael; Spann, Jim; Suggs, Robert

2010-01-01

The National Aeronautics and Space Administration (NASA) is launching a bold and ambitious new space initiative. A significant part of this new initiative includes exploration of new worlds, the development of more innovative technologies, and expansion our presence in the solar system. A common theme to this initiative is the exploration of space beyond Low Earth Orbit (LEO). As currently organized, NASA does not have an Agency-level office that provides coordination of space environment research and development. This has contributed to the formation of a gap between spaceflight environments knowledge and the application of this knowledge for multi-program use. This paper outlines a concept to establish a NASA-level Applied Spaceflight Environments (ASE) office that will provide coordination and funding for sustained multi-program support in three technical areas that have demonstrated these needs through customer requests. These technical areas are natural environments characterization and modeling, materials and systems analysis and test, and operational space environments modeling and prediction. This paper will establish the need for the ASE, discuss a concept for organizational structure and outline the scope in the three technical areas

Career Exploration Program Exit Presentation

NASA Technical Reports Server (NTRS)

Wotring, Virginia; Hood, Andrew

2013-01-01

Mouse liver cells on short-term shuttle flights (STS- 135) have been shown to exhibit changes. By replicating aspects of spaceflight in the laboratory, we can conduct experiments without impacting mission resources. Astronauts are on a high-iron diet during spaceflight. Galactic Cosmic Rays (GCRs) and Solar Particle Events (SPEs) are ionizing radiation sources that can alter physiological functions. Preliminary medication usage data from the International Space Station (ISS) crew shows that the most common reasons for using medications in space are the same for healthy people on earth.

Avionics Architectures for Exploration: Wireless Technologies and Human Spaceflight

NASA Technical Reports Server (NTRS)

Goforth, Montgomery B.; Ratliff, James E.; Barton, Richard J.; Wagner, Raymond S.; Lansdowne, Chatwin

2014-01-01

The authors describe ongoing efforts by the Avionics Architectures for Exploration (AAE) project chartered by NASA's Advanced Exploration Systems (AES) Program to evaluate new avionics architectures and technologies, provide objective comparisons of them, and mature selected technologies for flight and for use by other AES projects. The AAE project team includes members from most NASA centers and from industry. This paper provides an overview of recent AAE efforts, with particular emphasis on the wireless technologies being evaluated under AES to support human spaceflight.

Shuttle - Mir Program Insignia

NASA Image and Video Library

1994-09-20

The rising sun signifies the dawn of a new era of human Spaceflight, the first phase of the United States/Russian space partnership, Shuttle-Mir. Mir is shown in its proposed final on orbit configuration. The Shuttle is shown in a generic tunnel/Spacehab configuration. The Shuttle/Mir combination, docked to acknowledge the union of the two space programs, orbits over an Earth devoid of any definable features or political borders to emphasize Earth as the home planet for all humanity. The individual stars near the Space Shuttle and the Russian Mir Space Station represent the previous individual accomplishments of Russia's space program and that of the United States. The binary star is a tribute to the previous United States-Russian joint human Spaceflight program, the Apollo-Soyuz Test Project (ASTP). The flags of the two nations are symbolized by flowing ribbons of the national colors interwoven in space to represent the two nations joint exploration of space. NASA SHUTTLE and PKA MNP are shown in the stylized logo fonts of the two agencies that are conducting this program.

Spaceflight Radiation Health program at the Lyndon B. Johnson Space Center

NASA Technical Reports Server (NTRS)

Johnson, A. Steve; Badhwar, Gautam D.; Golightly, Michael J.; Hardy, Alva C.; Konradi, Andrei; Yang, Tracy Chui-Hsu

1993-01-01

The Johnson Space Center leads the research and development activities that address the health effects of space radiation exposure to astronaut crews. Increased knowledge of the composition of the environment and of the biological effects of space radiation is required to assess health risks to astronaut crews. The activities at the Johnson Space Center range from quantification of astronaut exposures to fundamental research into the biological effects resulting from exposure to high energy particle radiation. The Spaceflight Radiation Health Program seeks to balance the requirements for operational flexibility with the requirement to minimize crew radiation exposures. The components of the space radiation environment are characterized. Current and future radiation monitoring instrumentation is described. Radiation health risk activities are described for current Shuttle operations and for research development program activities to shape future analysis of health risk.

Physiological constraints on deceleration during the aerocapture of manned vehicles

NASA Technical Reports Server (NTRS)

Lyne, J. E.

1992-01-01

The peak deceleration load allowed for aerobraking of manned vehicles is a critical parameter in planning future excursions to Mars. However, considerable variation exists in the limits used by various investigators. The goal of this study was to determine the most appropriate level for this limit. Methods: Since previous U.S. space flights have been limited to 84 days duration, Soviet flight results were examined. Published details of Soviet entry trajectories were not available. However, personal communication with Soviet cosmonauts suggested that peak entry loads of 5-6 G had been encountered upon return from 8 months in orbit. Soyuz entry capsule's characteristics were established and the capsule's entry trajectory was numerically calculated. The results confirm a peak load of 5 to 6 G. Results: Although the Soviet flights were of shorter duration than expected Mars missions, evidence exists that the deceleration experience is applicable. G tolerance has been shown to stabilize after 1 to 3 months in space if adequate countermeasures are used. The calculated Soyuz deceleration histories are graphically compared with those expected for Mars aerobraking. Conclusions: Previous spaceflight experience supports the use of a 5 G limit for the aerocapture of a manned vehicle at Mars.

Stressors, stress and stress consequences during long-duration manned space missions: a descriptive model

NASA Astrophysics Data System (ADS)

Geuna, Stefano; Brunelli, Francesco; Perino, Maria A.

Keeping crew members in good health is a major factor in the success or failure of long-duration manned space missions. Among the many possible agents that can affect the crew's general well-being, stress is certainly one of the most critical because of its implications on human health and performance, both physical and mental. Nevertheless, very few studies have been performed on this fundamental issue and none of them has addressed it in its entirity, considering its diverse physical and psychological aspects. In this work, a descriptive model is proposed to expound the mechanism and sequence of events which mediate stress. A critical analysis of the information provided by past manned spaceflights and by dedicated research performed in analogous environments is presented, and an extrapolation of the available data on human stress in such extreme conditions is proposed. Both internal and external stressors have been identified, at physical and psychosocial levels, thus providing the basis for their early detection and preventive reduction. The possible negative consequences of stress that may lead to disease in crewmembers are described. Finally, the most effective instruments which may be of help in reducing space-related human stress and treating its negative consequences are suggested.

Review of Human Cognitive Performance in Spaceflight

NASA Technical Reports Server (NTRS)

Strangman, Gary; Bevan, Gary

2012-01-01

Human space exploration is inherently hazardous, particularly for lon g duration (LD) missions (22 days or longer). Maintenance of cognitive functioning is essential, but flight environments pose numerous pote ntial risks to the brain and cognitive performance (eg, radiation, to xins, chronic stress, sleep deprivation, hypercarbia, fluid shifts, h ormone imbalances, and injury). There have been persistent anecdotal reports of cognitive deficits during missions, but an up?-to-date rev iew of the evidence for such changes has remained unavailable. Method s: We identified and reviewed English language publications found via electronic searches in PubMed, PsycInfo, Inspec, the NASA Technical Report Server, and the Defense Technical Information Center, plus rec ursive searches of publication bibliographies. Search terms included the word cognition, cognitive, or performance along with spaceflight, flight, mission, or closely related terms. Results: Inter?-study variability precluded meta?-analysis. Some 32 published studies involving cognitive assessment during spaceflight were identified, involving a total of 110 participants (mean: 3.4 participants per study). The lo ngest?-duration study spanned 438 days, with six additional studies i nvolving flight durations of 90 days, and 11 more studies involved fl ight durations exceeding 21 days. The available evidence failed to st rongly support or refute the existence of cognitive deficits in LD sp aceflight, in part due to inadequate power or control conditions. Evi dence of increased variability in cognitive performance during spacef light, both within and between individuals, was common. Discussion: T hese results represent a negative finding based on small numbers of s ubjects for any given cognitive function. The increased variability within and (particularly) between individuals highlights the potential danger of generalizing from case studies. A mismatch therefore remain s between anecdotal reports describing generalized cognitive slowing, attention and memory problems during missions and the experimental e vidence supporting such deficits. Since a major justification for man ned spaceflight rests with the cognitive flexibility of humans, addit ional studies and further analysis of existing operational data appea rs warranted.

Developing a Strategic Plan for NASA JSC's Technology Investments

NASA Technical Reports Server (NTRS)

Stecklein, Jonette M.

2012-01-01

Human space exploration has always been heavily influenced by goals to achieve a specific mission on a specific schedule. This approach drove rapid technology development, the rapidity of which adds risks as well as provides a major driver for costs. The National Aeronautics and Space Administration (NASA) is now approaching the extension of human presence throughout the solar system by balancing a proactive yet less schedule-driven development of technology with opportunistic scheduling of missions as the needed technologies are realized. This approach should provide cost effective, low risk technology development that will enable efficient and effective manned spaceflight missions. As a first step, the NASA Human Spaceflight Architecture Team (HAT) has identified a suite of critical technologies needed to support future manned missions across a range of destinations, including in cislunar space, near earth asteroid visits, lunar exploration, Mars space, and Mars exploration. The challenge now is to develop a strategy and plan for technology development that efficiently enables these missions over a reasonable time period, without increasing technology development costs unnecessarily due to schedule pressure, and subsequently mitigating development and mission risks. NASA fs Johnson Space Center (JSC), as the nation's primary center for human exploration, is addressing this challenge through an innovative approach allocating Internal Research and Development funding to projects that have been prioritized using four focus criteria, with appropriate importance weighting. These four focus criteria are the Human Space Flight Technology Needs, JSC Core Technology Competencies, Commercialization Potential, and Partnership Potential. The inherent coupling in these focus criteria have been captured in a database and have provided an initial prioritization for allocation of technology development research funding. This paper will describe this process and this database, and the preliminary technology development prioritization results.

Spaceflight-relevant stem education and outreach: Social goals and priorities

NASA Astrophysics Data System (ADS)

Caldwell, Barrett S.

2015-07-01

This paper is based on a presentation and conference proceedings paper given at the 65th International Astronautical Congress. The paper addresses concerns in education and public outreach (EPO) in science, technology, engineering and mathematics (STEM). The author serves as a Director of a US statewide NASA-funded Space Grant Consortium, with responsibilities to coordinate funding for undergraduate scholarships, graduate fellowships, and program awards. Space Grant is a national NASA network of STEM EPO programs including over 1000 higher education, outreach center, science museum, local government, and corporate partners. As a Space Grant Director, the author interacts with a variety of levels of STEM literacy and sophistication among members of the public. A number of interactions highlight the need for STEM EPO leaders to speak directly to a variety of social goals and priorities. Spaceflight is largely seen as an appealing and potentially desirable STEM application. However, members of the public are often unclear and ill-informed regarding relative expense, relative benefit, and relative breadth of domains of expertise that are relevant to the spaceflight enterprise. In response (and resulting in further disconnects between STEM specialists and the public), focused STEM professionals frequently over-emphasize their own technical specialty and its priority in general because of its importance to that professional. These potential divides in the attempt to share and connect STEM related goals and priorities are discussed as an elaboration of invitations to discuss spacefaring in "futures forum" contexts. Spaceflight can be seen as addressing a combination of "actualization" and "aspirational" goals at social and societal levels. Maslow's hierarchy of needs distinguishes between "basic needs" and "actualization" as a higher-order need. Another aspect of spaceflight is aspirational-it speaks to hopes and desires for levels of flexibility and capability at the societal level. One analogy is the marketing of premium brand luxury items, at lower cost and larger volumes, to larger segments of the population. STEM EPO activities should not be directed solely at the "rocket science" applications of technology and engineering capabilities. Additional effort is needed to connect spaceflight experiences and examples to broader STEM needs, social priorities, and local contexts.

Commercial Spacewalking: Designing an EVA Qualification Program for Space Tourism

NASA Technical Reports Server (NTRS)

Gast, Matthew A.

2010-01-01

In the near future, accessibility to space will be opened to anyone with the means and the desire to experience the weightlessness of microgravity, and to look out upon both the curvature of the Earth and the blackness of space, from the protected, shirt-sleeved environment of a commercial spacecraft. Initial forays will be short-duration, suborbital flights, but the experience and expertise of half a century of spaceflight will soon produce commercial vehicles capable of achieving low Earth orbit. Even with the commercial space industry still in its infancy, and manned orbital flight a number of years away, there is little doubt that there will one day be a feasible and viable market for those courageous enough to venture outside the vehicle and into the void, wearing nothing but a spacesuit, armed with nothing but preflight training. What that Extravehicular Activity (EVA) preflight training entails, however, is something that has yet to be defined. A number of significant factors will influence the composition of a commercial EVA training program, but a fundamental question remains: 'what minimum training guidelines must be met to ensure a safe and successful commercial spacewalk?' Utilizing the experience gained through the development of NASA's Skills program - designed to qualify NASA and International Partner astronauts for EVA aboard the International Space Station - this paper identifies the attributes and training objectives essential to the safe conduct of an EVA, and attempts to conceptually design a comprehensive training methodology meant to represent an acceptable qualification standard.

Corrosion Protection for Space and Beyond

NASA Technical Reports Server (NTRS)

Calle, Luz Marina

2007-01-01

Florida is home to NASA's Launch Operations Center. Since its establishment in July 1962, the spaceport has served as the departure gate for every American manned mission and hundreds of advanced scientific spacecraft under the Launch Services Program. The center was renamed the John F. Kennedy Space Center in late 1963 to honor the president who put America on the path to the moon. Today, NASA is on the edge of a bold new chaIlenge: the ConsteIlation Program. ConsteIlation is a NASA program to create a new generation of spacecraft for human spaceflight, consisting primarily of the Ares I and Ares V launch vehicles, the Orion crew capsule, the Earth Departure stage and the Lunar access module. These spacecraft will be capable of performing a variety of missions, from Space Station resupply to lunar landings. The ambitious new endeavor caIls for NASA to return human explorers to the moon and then venture even farther, to Mars and beyond. As the nation's premier spaceport, Kennedy Space Center (KSC) will playa critical role in this new chapter in exploration, particularly in the conversion of the launch facilities to accommodate the new launch vehicles. To prepare for this endeavor, the launch site and facilities for the next generation of crew and cargo vehicles must be redesigned, assembled and tested. One critical factor that is being carefuIly considered during the renovation is protecting the new facilities and structures from corrosion and deterioration.

Burning Questions in Gravity-Dependent Combustion Science

NASA Technical Reports Server (NTRS)

Urban, David; Chiaramonte, Francis P.

2012-01-01

Building upon a long history of spaceflight and ground based research, NASA's Combustion Science program has accumulated a significant body of accomplishments on the ISS. Historically, NASAs low-gravity combustion research program has sought: to provide a more complete understanding of the fundamental controlling processes in combustion by identifying simpler one-dimensional systems to eliminate the complex interactions between the buoyant flow and the energy feedback to the reaction zone to provide realistic simulation of the fire risk in manned spacecraft and to enable practical simulation of the gravitational environment experienced by reacting systems in future spacecraft. Over the past two decades, low-gravity combustion research has focused primarily on increasing our understanding of fundamental combustion processes (e.g. droplet combustion, soot, flame spread, smoldering, and gas-jet flames). This research program was highly successful and was aided by synergistic programs in Europe and in Japan. Overall improvements were made in our ability to model droplet combustion in spray combustors (e.g. jet engines), predict flame spread, predict soot production, and detect and prevent spacecraft fires. These results provided a unique dataset that supports both an active research discipline and also spacecraft fire safety for current and future spacecraft. These experiments have been conducted using the Combustion Integrated Rack (CIR), the Microgravity Science Glovebox and the Express Rack. In this paper, we provide an overview of the earlier space shuttle experiments, the recent ISS combustion experiments in addition to the studies planned for the future. Experiments in combustion include topics such as droplet combustion, gaseous diffusion flames, solid fuels, premixed flame studies, fire safety, and super critical oxidation processes.

The Moonlandings

NASA Astrophysics Data System (ADS)

Turnill, Reginald

2002-12-01

The Soviet-American race to land the first man on the Moon was a technical challenge unlike anything in modern human history. BBC Aerospace Correspondent Reginald Turnill covered the story, and his reports were heard and seen by millions worldwide. With unparalleled access to the politicians, scientists, and technicians involved in the race to the Moon, Turnill knew all the early astronauts--Alan Shepard, John Glenn, Neil Armstrong, Buzz Aldrin--as they pioneered the techniques that made the Moon landings possible. He became a friend of Dr. Wernher von Braun, the German rocket pioneer and mastermind behind the technology. Turnill's unique eyewitness account of one of the most thrilling adventures of the twentieth century is clearly written and is packed with action and drama, making this a fascinating read for all those interested in the story of the race to the Moon. Reginald Turnill started work in Fleet Street at the age of 15, and by 19 he was covering the national news as a Press Association staff reporter. After joining the BBC in 1956 he covered the launch of Sputnik 1 and found it so exciting that he made space reporting his speciality. As the BBC Aerospace Correspondent, Turnill spent the rest of his career covering all the manned space missions as well as planetary missions like Mariner, Pioneer, Viking, and Voyager. Since leaving the BBC staff, Turnill has continued to broadcast and write on space, and he created the first spaceflight directory. Turnill is the only non-American to have been presented with NASA's Chroniclers Award for contributions to public understanding of the space program.

Design of a CAN bus interface for photoelectric encoder in the spaceflight camera

NASA Astrophysics Data System (ADS)

Sun, Ying; Wan, Qiu-hua; She, Rong-hong; Zhao, Chang-hai; Jiang, Yong

2009-05-01

In order to make photoelectric encoder usable in a spaceflight camera which adopts CAN bus as the communication method, CAN bus interface of the photoelectric encoder is designed in this paper. CAN bus interface hardware circuit of photoelectric encoder consists of CAN bus controller SJA 1000, CAN bus transceiver TJA1050 and singlechip. CAN bus interface controlling software program is completed in C language. A ten-meter shield twisted pair line is used as the transmission medium in the spaceflight camera, and speed rate is 600kbps.The experiments show that: the photoelectric encoder with CAN bus interface which has the advantages of more reliability, real-time, transfer rate and transfer distance overcomes communication line's shortcomings of classical photoelectric encoder system. The system works well in automatic measuring and controlling system.

NASA directory of observation station locations, volume 1

NASA Technical Reports Server (NTRS)

1973-01-01

Geodetic information for NASA tracking stations and for observation stations cooperating in NASA geodetic satellite programs is presented. A Geodetic Data Sheet is provided for each station, giving the position of the station and describing briefly how it was established. Geodetic positions and geocentric coordinates of these stations are tabulated on local or major geodetic datums and on selected world geodetic systems. The principal tracking facilities used by NASA, including the Spaceflight Tracking and Data Network, the Deep Space Network, and several large radio telescopes are discussed. Positions of these facilities are tabulated on their local or national datums, the Mercury Spheroid 1960, the Modified Mercury Datum 1968, and the Spaceflight Tracking and Data Network System. Observation stations in the NASA Geodetic Satellites Program are included along with stations participating in the National Geodetic Satellite Program. Positions of these facilities are given on local or preferred major datums, and on the Modified Mercury Datum 1968.

Extreme Cost Growth: Themes from Six U.S. Air Force Major Defense Acquisition Programs

DTIC Science & Technology

2015-01-01

launch company SpaceX brought anti-trust litigation against the ULA as early as 2005, arguing that the agreement foreclosed competition. Legal maneuvering...was still under way through 2014. See “ SpaceX and ULA Go Toe-to-Toe Over EELV Contracts,” NASA Spaceflight.com, March 5, 2014. 16 Again, it is...December 9, 2014: http://www.rand.org/pubs/papers/P4748.html “ SpaceX and ULA Go Toe-to-Toe Over EELV Contracts,” NASA Spaceflight.com, March 5

Human Behaviour in Long-Term Missions

NASA Technical Reports Server (NTRS)

1997-01-01

In this session, Session WP1, the discussion focuses on the following topics: Psychological Support for International Space Station Mission; Psycho-social Training for Man in Space; Study of the Physiological Adaptation of the Crew During A 135-Day Space Simulation; Interpersonal Relationships in Space Simulation, The Long-Term Bed Rest in Head-Down Tilt Position; Psychological Adaptation in Groups of Varying Sizes and Environments; Deviance Among Expeditioners, Defining the Off-Nominal Act in Space and Polar Field Analogs; Getting Effective Sleep in the Space-Station Environment; Human Sleep and Circadian Rhythms are Altered During Spaceflight; and Methodological Approach to Study of Cosmonauts Errors and Its Instrumental Support.

The squirrel monkey as a candidate for space flight

NASA Technical Reports Server (NTRS)

Brizzee, K. R.; Ordy, J. M.; Kaack, B.

1977-01-01

Because of its size and other unique diurnal-primate characteristics, the squirrel monkey is used in: (1) actual bioflight missions, (2) in laboratory tests designed to clarify the risks to man during launch and recovery as well as in hazardous spaceflight environments; and (3) in the acquisition of data on unknown risks encountered in long duration space exploration. Pertinent data concerning samiri sciureus as described in published and unpublished reports are summarized. Topics include: taxonomy, ethology, life history, sensory-learning-motor capabilities in primate perspective, anatomy and physiology (including homeostatic adaptation to stress), susceptibility to environmental hazards, reproduction, care and clinical management, and previous use in aerospace biomedical research.

STS-1 - INSIGNIAS

NASA Image and Video Library

1986-02-19

S86-27614 (Feb 1986) --- The Space Shuttle Columbia is at the center of the Spacelab Life Sciences 1 patch. The various elements of the logo serve to deliver the message of the dedication of this mission to medical and biological studies, a first for manned spaceflight. A crew of five NASA astronauts and two payload specialists will be split into shifts to maximize the exposure to space environment for variegated and thorough biological and medical experiments during the scheduled ten-day mission. The crew will maintain a constant communications link with scientists on Earth, considered by the flight crew to be an integral part of the overall mission, as well.

Future heliospheric missions from Russian perspective

NASA Astrophysics Data System (ADS)

Petrukovich, Anatoli; Izmodenov, Vladislav; Zelenyi, Lev; Kuzin, Sergey; Kuznetsov, Vladimir; Eismont, Natan

Structure and plasma processes of the heliosphere will be in the focus of attention for the next decade with the launch of Solar Orbiter, Solar Probe Plus, Interhelioprobe and SPORT, as well as the continuing flight of Voyagers and New Horizons. We review possible scientific goals and technical challenges for even more distant projects which are under discussion now. The projects include high-ecliptic observations with the help of solar sail, remote observations of heliospheric outer boundaries with interstellar medium as well as local high resolution turbulence studies. A major future challenge for the space weather research is the support for manned spaceflight beyond low Earth orbit.

Spaceflight and immune responses of Rhesus monkeys

NASA Technical Reports Server (NTRS)

Sonnenfeld, Gerald

1994-01-01

Evidence from both human and rodent studies indicates that alterations in immunological parameters occur after space flight. The objective of this project is to determine the effects of space flight on immune responses of Rhesus monkeys. The expected significance of the work is a determination of the range of immunological functions of the Rhesus monkey, a primate similar in many ways to man, affected by space flight. Changes in immune responses that could yield alterations in resistance to infection may be determined as well as the duration of alterations in immune responses. Additional information on the nature of cellular interactions for the generation of immune responses may also be obtained.

Graphene Field Effect Transistor for Radiation Detection

NASA Technical Reports Server (NTRS)

Li, Mary J. (Inventor); Chen, Zhihong (Inventor)

2016-01-01

The present invention relates to a graphene field effect transistor-based radiation sensor for use in a variety of radiation detection applications, including manned spaceflight missions. The sensing mechanism of the radiation sensor is based on the high sensitivity of graphene in the local change of electric field that can result from the interaction of ionizing radiation with a gated undoped silicon absorber serving as the supporting substrate in the graphene field effect transistor. The radiation sensor has low power and high sensitivity, a flexible structure, and a wide temperature range, and can be used in a variety of applications, particularly in space missions for human exploration.

LAUNCH - STS-1 - KSC

NASA Image and Video Library

1981-04-12

S81-30498 (12 April 1981) --- After six years of silence, the thunder of manned spaceflight is heard again, as the successful launch of the first space shuttle ushers in a new concept in utilization of space. The April 12, 1981 launch, at Pad 39A, just seconds past 7 a.m., carries astronaut John Young and Robert Crippen into an Earth-orbital mission scheduled to last for 54 hours, ending with unpowered landing at Edwards Air Force Base in California. STS-1, the first in a series of shuttle vehicles planned for the Space Transportation System, utilizes reusable launch and return components. Photo credit: NASA or National Aeronautics and Space Administration

Vehicle for Space Transfer and Recovery (VSTAR), volume 1

NASA Technical Reports Server (NTRS)

1988-01-01

The Vehicle Space Transfer and Recovery (VSTAR) system is designed as a manned orbital transfer vehicle (MOTV) with the primary mission of Satellite Launch and Repair (SLR). VSTAR will provide for economic use of high altitude spaceflight for both the public and private sector. VSTAR components will be built and tested using earth based facilities. These components will then be launched using the space shuttle, into low earth orbit (LEO) where it will be constructed on a U.S. built space station. Once in LEO the vehicle components will be assembled in modules which can then be arranged in various configurations to perform the required missions.

Programmatic Considerations to Reduce the Risk of Adverse Renal Stone Events in Spaceflight

NASA Technical Reports Server (NTRS)

Antonsen, Erik; Pietrzyk, Robert

2017-01-01

Introduction: Microgravity exposure may alter the likelihood that astronauts will experience renal stones. The potential risk includes both acute and chronic health issues, with the potential for significant impact on mission objectives. Methods: To understand the role of the NASA's Human Research Program (HRP) research agenda in both preventing and addressing renal stones in spaceflight, current astronaut epidemiologic data and a summary of programmatic considerations are reviewed. Results: Although there has never been a symptomatic renal stone event in a U.S. crewmember during spaceflight, urine chemistry has been altered - likely due to induced changes in renal physiology as a result of exposure to microgravity. This may predispose astronauts to stone formation, leading the HRP to conduct and sponsor research to: 1) understand the risk of stone formation in space; 2) prevent stones from forming; and 3) address stones that may form by providing novel diagnostic and therapeutic approaches. Discussion: The development of a renal stone during spaceflight is a significant medical concern that requires the HRP to minimize this risk by providing the ability to prevent, diagnose, monitor and treat the condition during spaceflight. A discussion of the risk as NASA understands it is followed by an overview of the multiple mitigations currently under study, including novel ultrasound techniques for stone detection and manipulation, and how they may function as part of a larger exploration medical system.

KSC-2011-3329

NASA Image and Video Library

2011-05-05

CAPE CANAVERAL, Fla. -- Program participants pose for a group photo in front of a replica of a Mercury-Redstone rocket during a celebration at Complex 5/6 on Cape Canaveral Air Force Station in Florida. From left are Hugh Harris, former director of Public Affairs at Kennedy Space Center; Alice Wackermann, Julie Jenkins and Laura Churchley, daughters of astronaut Alan Shepard; Jack King, former chief, Public Information Office, Marshall Space Flight Center; Bob Moser, former chief test conductor for the Mercury-Redstone launches; NBC reporter Jay Barbree; Mercury astronaut Scott Carpenter; Kennedy Space Center Director Bob Cabana; Lieutenant General Susan J. Helms, commander of the 14th Air Force and former astronaut; and NASA Administrator Charlie Bolden. The celebration was held at the launch site of the first U.S. manned spaceflight May 5, 1961, to mark the 50th anniversary of the flight. Fifty years ago, astronaut Alan Shepard lifted off inside the Mercury capsule, "Freedom 7," atop an 82-foot-tall Mercury-Redstone rocket at 9:34 a.m. EST, sending him on a remarkably successful, 15-minute suborbital flight. The event was attended by more than 200 workers from the original Mercury program and included a re-creation of Shepard's flight and recovery, as well as a tribute to his contributions as a moonwalker on the Apollo 14 lunar mission. For more information, visit www.nasa.gov/topics/history/milestones/index.html. Photo credit: NASA/Kim Shiflett

Hearing loss in space

NASA Technical Reports Server (NTRS)

Buckey, J. C. Jr; Musiek, F. E.; Kline-Schoder, R.; Clark, J. C.; Hart, S.; Havelka, J.

2001-01-01

BACKGROUND: Temporary and, in some cases, permanent hearing loss has been documented after long-duration spaceflights. METHODS: We examined all existing published data on hearing loss after space missions to characterize the losses. RESULTS: Data from Russian missions suggest that the hearing loss, when it occurs, affects mainly mid to high frequencies and that using hearing protection often might prevent the loss. Several significant questions remain about hearing loss in space. While the hearing loss has been presumed to be noise-induced, no clear link has been established between noise exposure and hearing loss during spaceflight. In one documented case of temporary hearing loss from the Shuttle-Mir program, the pattern of loss was atypical for a noise-induced loss. Continuous noise levels that have been measured on the Mir and previous space stations, while above engineering standards, are not at levels usually associated with hearing loss in ground-based studies (which have usually been limited to 8-10 h exposure periods). Attempts to measure hearing in space using threshold-based audiograms have been unsuccessful in both the American and Russian programs due to noise interference with the measurements. CONCLUSIONS: The existing data highlight the need for reliable monitoring of both hearing and noise in long-duration spaceflight.

Synthetic torpor: A method for safely and practically transporting experimental animals aboard spaceflight missions to deep space.

PubMed

Griko, Yuri; Regan, Matthew D

2018-02-01

Animal research aboard the Space Shuttle and International Space Station has provided vital information on the physiological, cellular, and molecular effects of spaceflight. The relevance of this information to human spaceflight is enhanced when it is coupled with information gleaned from human-based research. As NASA and other space agencies initiate plans for human exploration missions beyond low Earth orbit (LEO), incorporating animal research into these missions is vitally important to understanding the biological impacts of deep space. However, new technologies will be required to integrate experimental animals into spacecraft design and transport them beyond LEO in a safe and practical way. In this communication, we propose the use of metabolic control technologies to reversibly depress the metabolic rates of experimental animals while in transit aboard the spacecraft. Compared to holding experimental animals in active metabolic states, the advantages of artificially inducing regulated, depressed metabolic states (called synthetic torpor) include significantly reduced mass, volume, and power requirements within the spacecraft owing to reduced life support requirements, and mitigated radiation- and microgravity-induced negative health effects on the animals owing to intrinsic physiological properties of torpor. In addition to directly benefitting animal research, synthetic torpor-inducing systems will also serve as test beds for systems that may eventually hold human crewmembers in similar metabolic states on long-duration missions. The technologies for inducing synthetic torpor, which we discuss, are at relatively early stages of development, but there is ample evidence to show that this is a viable idea and one with very real benefits to spaceflight programs. The increasingly ambitious goals of world's many spaceflight programs will be most quickly and safely achieved with the help of animal research systems transported beyond LEO; synthetic torpor may enable this to be done as practically and inexpensively as possible. Published by Elsevier Ltd.

Synthetic torpor: A method for safely and practically transporting experimental animals aboard spaceflight missions to deep space

NASA Astrophysics Data System (ADS)

Griko, Yuri; Regan, Matthew D.

2018-02-01

Animal research aboard the Space Shuttle and International Space Station has provided vital information on the physiological, cellular, and molecular effects of spaceflight. The relevance of this information to human spaceflight is enhanced when it is coupled with information gleaned from human-based research. As NASA and other space agencies initiate plans for human exploration missions beyond low Earth orbit (LEO), incorporating animal research into these missions is vitally important to understanding the biological impacts of deep space. However, new technologies will be required to integrate experimental animals into spacecraft design and transport them beyond LEO in a safe and practical way. In this communication, we propose the use of metabolic control technologies to reversibly depress the metabolic rates of experimental animals while in transit aboard the spacecraft. Compared to holding experimental animals in active metabolic states, the advantages of artificially inducing regulated, depressed metabolic states (called synthetic torpor) include significantly reduced mass, volume, and power requirements within the spacecraft owing to reduced life support requirements, and mitigated radiation- and microgravity-induced negative health effects on the animals owing to intrinsic physiological properties of torpor. In addition to directly benefitting animal research, synthetic torpor-inducing systems will also serve as test beds for systems that may eventually hold human crewmembers in similar metabolic states on long-duration missions. The technologies for inducing synthetic torpor, which we discuss, are at relatively early stages of development, but there is ample evidence to show that this is a viable idea and one with very real benefits to spaceflight programs. The increasingly ambitious goals of world's many spaceflight programs will be most quickly and safely achieved with the help of animal research systems transported beyond LEO; synthetic torpor may enable this to be done as practically and inexpensively as possible.

Assessment of Human Factors

NASA Technical Reports Server (NTRS)

Mount, Frances; Foley, Tico

1999-01-01

Human Factors Engineering, often referred to as Ergonomics, is a science that applies a detailed understanding of human characteristics, capabilities, and limitations to the design, evaluation, and operation of environments, tools, and systems for work and daily living. Human Factors is the investigation, design, and evaluation of equipment, techniques, procedures, facilities, and human interfaces, and encompasses all aspects of human activity from manual labor to mental processing and leisure time enjoyments. In spaceflight applications, human factors engineering seeks to: (1) ensure that a task can be accomplished, (2) maintain productivity during spaceflight, and (3) ensure the habitability of the pressurized living areas. DSO 904 served as a vehicle for the verification and elucidation of human factors principles and tools in the microgravity environment. Over six flights, twelve topics were investigated. This study documented the strengths and limitations of human operators in a complex, multifaceted, and unique environment. By focusing on the man-machine interface in space flight activities, it was determined which designs allow astronauts to be optimally productive during valuable and costly space flights. Among the most promising areas of inquiry were procedures, tools, habitat, environmental conditions, tasking, work load, flexibility, and individual control over work.

Microgels for long-term storage of vitamins for extended spaceflight.

PubMed

Schroeder, R

2018-02-01

Biocompatible materials that can encapsulate large amounts of nutrients while protecting them from degrading environmental influences are highly desired for extended manned spaceflight. In this study, alkaline-degradable microgels based on poly(N-vinylcaprolactam) (PVCL) were prepared and analysed with their regard to stabilise retinol which acts as a model vitamin (vitamin A 1 ). It was investigated whether the secondary crosslinking of the particles with a polyphenol can prevent the isomerisation of biologically active all-trans retinol to biologically inactive cis-trans retinol. Both loading with retinol and secondary crosslinking of the particles was performed at room temperature to prevent an early degradation of the vitamin. This study showed that PVCL microgels drastically improve the water solubility of hydrophobic retinol. Additionally, it is demonstrated that the highly crosslinked microgel particles in aqueous solution can be utilised to greatly retard the light- and temperature-induced isomerisation process of retinol by a factor of almost 100 compared to pure retinol stored in ethanol. The use of microgels offers various advantages over other drug delivery systems as they exhibit enhanced biocompatibility and superior aqueous solubility. Copyright © 2017 The Committee on Space Research (COSPAR). Published by Elsevier Ltd. All rights reserved.

Research opportunities in cardiovascular deconditioning, phase 1

NASA Technical Reports Server (NTRS)

Levy, M. N. (Editor); Talbot, J. M. (Editor)

1983-01-01

The deconditioning of the cardiovascular system that occurs during spaceflight, NASA's current and projected research program, and the conclusions and suggestions of the ad hoc Working Group are summarized.

Liquid Dynamics from Spacelab to Sloshsat

NASA Astrophysics Data System (ADS)

Vreeburg, Jan P. B.

2009-01-01

The European participation in manned spaceflight had a strong impact on research in the natural sciences because weightlessness became available as experimental condition. Preparation for Spacelab required many decisions on organization, funding and allocation of resources. Lessons were learned from results obtained in precursors like Skylab or in unmanned programs such as TEXUS. ESA with scientists from the major disciplines instituted Working Groups that acted as consultant bodies. European experiment hardware has been realized by industry using specifications and not, traditionally, by evolution in a laboratory. The development of the Fluid Physics Module preceded many instruments for liquid research in space. The training of Payload Specialists for the operation of the FPM included theory of fluids and laboratory instruction. The dynamics of spacecraft with a partially filled tank can be studied in weightlessness only. Observation of the liquid behaviour inside the tank is a challenging problem but the momentum of the rigid part of the spacecraft can be tracked accurately. Analytical expressions for transient liquid flow in a moving tank should be identified, together with the tank motion. A validated model of liquid momentum transfer during spacecraft manoeuvres will make many missions more efficient and less costly. Sloshsat FLEVO was flown to provide reference data for this purpose.

Advances in Orion's On-Orbit Guidance and Targeting System Architecture

NASA Technical Reports Server (NTRS)

Scarritt, Sara K.; Fill, Thomas; Robinson, Shane

2015-01-01

NASA's manned spaceflight programs have a rich history of advancing onboard guidance and targeting technology. In order to support future missions, the guidance and targeting architecture for the Orion Multi-Purpose Crew Vehicle must be able to operate in complete autonomy, without any support from the ground. Orion's guidance and targeting system must be sufficiently flexible to easily adapt to a wide array of undecided future missions, yet also not cause an undue computational burden on the flight computer. This presents a unique design challenge from the perspective of both algorithm development and system architecture construction. The present work shows how Orion's guidance and targeting system addresses these challenges. On the algorithm side, the system advances the state-of-the-art by: (1) steering burns with a simple closed-loop guidance strategy based on Shuttle heritage, and (2) planning maneuvers with a cutting-edge two-level targeting routine. These algorithms are then placed into an architecture designed to leverage the advantages of each and ensure that they function in concert with one another. The resulting system is characterized by modularity and simplicity. As such, it is adaptable to the on-orbit phases of any future mission that Orion may attempt.

Safety and Performance Advantages of Nitrous Oxide Fuel Blends (NOFBX) Propellants for Manned and Unmanned Spaceflight Applications

NASA Astrophysics Data System (ADS)

Taylor, R.

2012-01-01

Hydrazine, N2H4, is the current workhorse monopropellant in the spacecraft industry. Although widely used since the 1960's, hydrazine is highly toxic and its specific impulse (ISP) performance of ~230s is far lower than bipropellants and solid motors. NOFBX™ monopropellants were originally developed under NASA's Mars Advanced Technology program (2004-2007) for deep space Mars missions. This work focused on characterizing various Nitrous Oxide Fuel Blend (NOFB) monopropellants which exhibited many favorable attributes to include: (1) Mono-propulsion, (2) Isp > 320s, (3) Non-toxic constituents, (4) Non-toxic effluents, (5) Low Cost, (6) High Density Specific Impulse, (7) Non-cryogenic, (8) Wide Storable Temperature Range, (9) Deeply throttlable [between 5 - 100lbs], (10) Self Pressurizing, (11) Wide Range of materials compatibility, along with many, many other benefits. All rocket propellants carry with them a history or stigma associated with either the development or implementation of that propellant and NOFBX™ is no exception. This paper examines the benefits of NOFBX™ propellants while addressing or dispelling a number of critiques N2O based propellants acquired through the decades of rocket propellant testing.

KSC-2011-3333

NASA Image and Video Library

2011-05-05

CAPE CANAVERAL, Fla. -- On Cape Canaveral Air Force Station in Florida, invited guests tour the blockhouse at Complex 5/6 during a celebration of Alan Shepard's historic flight 50 years ago. From left are Robert Sieck, former shuttle launch director; Andy Anderson, former manager for communications in the Mercury Mission Control Center; Bob Moser, former chief test conductor for the Mercury-Redstone launches; and John Twigg, former backup chief test conductor for the Mercury-Redstone launches. The celebration was held at the launch site of the first U.S. manned spaceflight May 5, 1961, to mark the 50th anniversary of the flight. Fifty years ago, astronaut Alan Shepard lifted off inside the Mercury capsule, "Freedom 7," atop an 82-foot-tall Mercury-Redstone rocket at 9:34 a.m. EST, sending him on a remarkably successful, 15-minute suborbital flight. The event was attended by more than 200 workers from the original Mercury program and included a re-creation of Shepard's flight and recovery, as well as a tribute to his contributions as a moonwalker on the Apollo 14 lunar mission. For more information, visit www.nasa.gov/topics/history/milestones/index.html. Photo credit: NASA/Kim Shiflett

Summary of Martian Dust Filtering Challenges and Current Filter Development

NASA Technical Reports Server (NTRS)

O'Hara, William J., IV

2017-01-01

Traditional air particulate filtering in manned spaceflight (Apollo, Shuttle, ISS, etc.) has used cleanable or replaceable catch filters such as screens and High-Efficiency Particulate Arrestance (HEPA) filters. However, the human mission to Mars architecture will require a new approach. It is Martian dust that is the particulate of concern but the need also applies to particulates generated by crew. The Mars Exploration Program Analysis Group (MEPAG) high-lighted this concern in its Mars Science, Goals, Objectives, Investigations and Priorities document [7], by saying specifically that one high priority investigation will be to "Test ISRU atmospheric processing systems to measure resilience with respect to dust and other environmental challenge performance parameters that are critical to the design of a full-scale system." By stating this as high priority the MEPAG is acknowledging that developing and adequately verifying this capability is critical to success of a human mission to Mars. This architecture will require filtering capabilities that are highly reliable, will not restrict the flow path with clogging, and require little to no maintenance. This paper will summarize why this is the case, the general requirements for developing the technology, and the status of the progress made in this area.

Orbiter Window Hypervelocity Impact Strength Evaluation

NASA Technical Reports Server (NTRS)

Estes, Lynda R.

2011-01-01

When the Space Shuttle Orbiter incurs damage on its windowpane during flight from particles traveling at hypervelocity speeds, it produces a distinctive damage that reduces the overall strength of the pane. This damage has the potential to increase the risk associated with a safe return to Earth. Engineers at Boeing and NASA/JSC are called to Mission Control to evaluate the damage and provide an assessment on the risk to the crew. Historically, damages like these were categorized as "accepted risk" associated with manned spaceflight, and as long as the glass was intact, engineers gave a "go ahead" for entry for the Orbiter. Since the Columbia accident, managers have given more scrutiny to these assessments, and this has caused the Orbiter window engineers to capitalize on new methods of assessments for these damages. This presentation will describe the original methodology that was used to asses the damages, and introduce a philosophy new to the Shuttle program for assessing structural damage, reliability/risk-based engineering. The presentation will also present a new, recently adopted method for assessing the damage and providing management with a reasonable assessment on the realities of the risk to the crew and vehicle for return.

Integrated shielding systems for manned interplanetary spaceflight

NASA Astrophysics Data System (ADS)

George, Jeffrey A.

1992-01-01

The radiation environment encountered by manned interplanetary missions can have a severe impact on both vehicle design and mission performance. This study investigates the potential impact of radiation protection on interplanetary vehicle design for a manned Mars mission. A systems approach was used to investigate the radiation protection requirements of the sum interplanetary environment. Radiation budgets were developed which result in minimum integrated shielding system masses for both nuclear and non-nuclear powered missions. A variety of system configurations and geometries were assessed over a range of dose constraints. For an annual dose equivalent rate limit of 50 rem/yr, an environmental shielding system composed of a habitat shield and storm shelter was found to result in the lowest total mass. For a limit of 65 rem/yr, a system composed of a sleeping quarters shield was least massive, and resulted in significantly reduced system mass. At a limit of 75 rem/yr, a storm shelter alone was found to be sufficient, and exhibited a further mass reduction. Optimal shielding system results for 10 MWe nuclear powered missions were found to follow along similar lines, with the addition of a reactor shadow shield. A solar minimum galactic cosmic ray spectrum and one anomalously large solar particle event during the course of a two year mission were assumed. Water was assumed for environmental radiation shielding.

Medical and Scientific Evaluations aboard the KC-135. Microgravity-Compatible Flow Cytometer

NASA Technical Reports Server (NTRS)

Crucian, Brian; Nelman-Gonzalez, Mayra; Sams, Clarence

2005-01-01

A spaceflight-compatible flow cytometer would be useful for the diagnosis of astronaut illness during long duration spaceflight and for conducting in-flight research to evaluate the effects of microgravity on human physiology. Until recently, the primary limitations preventing the development of a spaceflight compatible flow cytometer have been largely mechanical. Standard commercially available flow cytometers are large, complex instruments that use high-energy lasers and require significant training to operate. Standard flow cytometers function by suspending the particles to be analyzed inside a sheath fluid for analysis. This requires the presence of several liters of sheath fluid for operation, and generates a corresponding amount of liquid hazardous waste. The particles are then passed through a flow cell which uses the fluid mechanical property of hydrodynamic focusing to place the cells in single-file (laminar flow) as they pass through a laser beam for scanning and evaluation. Many spaceflight experiments have demonstrated that fluid physics is dramatically altered in microgravity (MSF [Manned Space Flight] Fluid Physics Data Sheet-August 1997) and previous studies have shown that sheath-fluid based hydrodynamic focusing may also be altered during microgravity (Crucian et al, 2000). For these reasons it is likely that any spaceflight compatible design for a flow cytometer would abandon the sheath fluid requirement. The elimination of sheath fluid would remove both the problems of weight associated with large volumes of liquids as well as the large volume of liquid waste generated. It would also create the need for a method to create laminar particle flow distinct from the standard sheath-fluid based method. The spaceflight prototype instrument is based on a recently developed commercial flow cytometer possessing a novel flow cell design that creates single-particle laser scanning and evaluation without the need for sheath-fluid based hydrodynamic focusing. This instrument also possesses a number of design advances that make it conditionally microgravity compatible: it is highly miniaturized and lightweight, uses a low energy diode laser, has a small number of moving parts, does not use sheath fluid and does not generate significant liquid waste. Although possessing certain limitations, the commercial cytometer functions operationally like a standard bench top laboratory flow cytometer, aspirating liquid particle samples and generating histogram or dot-plot data in standard FCS file format. In its current configuration however, the cytometer is limited to three parameter/two-color capability (two color PMTs + forward scatter), does not allow compensation between colors, does not allow linear analysis and is operated by rather inflexible software with limited capabilities. This is due to the fact that the cytometer has been designed and marketed as an instrument specific to a few particular assays, not as a multipurpose cytometer.

NASA Pocket Statistics

NASA Technical Reports Server (NTRS)

1983-01-01

The following subject areas are covered: summary of the NASA program goals and objectives; major mission performance; USSR spaceflights; summary comparisons of the USA and USSR space records; and selected technical, financial, and manpower data.

Astronaut McDivitt - Blood Pressure Check - Preflight Examination - Merritt Island, FL

NASA Image and Video Library

1965-06-01

S65-19524 (1 June 1965) --- Dr. Charles A. Berry, chief of Center Medical Programs, MSC, Houston, Texas, prepares to check the blood pressure of astronaut James A. McDivitt, command pilot for the Gemini-Titan 4 spaceflight. McDivitt is on the tilt table at the Aero Medical Area, MSC, Merritt Island, where he and astronaut Edward H. White II (out of frame), GT-4 pilot, underwent preflight physicals in preparation for the four-day, 62-revolution spaceflight. The two astronauts were declared in top physical condition. In the background is Dr. Gordon Benson, NASA physician at Cape Kennedy.

Influence of zero-G on single-cell systems and zero-G fermenter design concepts

NASA Technical Reports Server (NTRS)

Mayeux, J. V.

1977-01-01

An analysis was made to identify potential gravity-sensitive mechanisms that may be present in the single-cell growth system. Natural convection (density gradients, induced sedimentation, and buoyancy) is important in microbial systems. The absence of natural convection in the space-flight environment could provide an opportunity for new approaches for developments in industrial fermentation and agriculture. Some of the potential influences of gravity (i.e., convection, sedimentation, etc.) on the cell were discussed to provide insight into what experimental areas may be pursued in future space-flight research programs.

Soviet Space Programs: 1976-80 (With Supplementary Data through 1983). Manned Space Programs and Space Life Sciences. Part 2. Prepared at the Request of Hon. Bob Packwood, Chairman, Committee on Commerce, Science, and Transportation, United States Senate, Ninety-Eighth Congress, Second Session.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. Senate Committee on Commerce, Science, and Transportation.

This report, the second of a three-part study of Soviet space programs, examines their manned space programs and reviews their quest for a permanently manned presence in space. Also included is information concerning the physiological and psychological findings related to the extended duration of Soviet manned flights and an executive summary.…

Decision Making in the Airplane

NASA Technical Reports Server (NTRS)

Orasanu, Judith; Shafto, Michael G. (Technical Monitor)

1995-01-01

The Importance of decision-making to safety in complex, dynamic environments like mission control centers, aviation, and offshore installations has been well established. NASA-ARC has a program of research dedicated to fostering safe and effective decision-making in the manned spaceflight environment. Because access to spaceflight is limited, environments with similar characteristics, including aviation and nuclear power plants, serve as analogs from which space-relevant data can be gathered and theories developed. Analyses of aviation accidents cite crew judgement and decision making as causes or contributing factors in over half of all accidents. Yet laboratory research on decision making has not proven especially helpful In improving the quality of decisions in these kinds of environments. One reason is that the traditional, analytic decision models are inappropriate to multi-dimensional, high-risk environments, and do not accurately describe what expert human decision makers do when they make decisions that have consequences. A new model of dynamic, naturalistic decision making is offered that may prove useful for improving decision making in complex, isolated, confined and high-risk environments. Based on analyses of crew performance in full-mission simulators and accident reports, features that define effective decision strategies in abnormal or emergency situations have been identified. These include accurate situation assessment (including time and risk assessment), appreciation of the complexity of the problem, sensitivity to constraints on the decision, timeliness of the response, and use of adequate information. More effective crews also manage their workload to provide themselves with time and resources to make good decisions. In brief, good decisions are appropriate to the demands of the situation. Effective crew decision making and overall performance are mediated by crew communication. Communication contributes to performance because it assures that all crew members have essential information, but it also regulates and coordinates crew actions and is the medium of collective thinking In response to a problem, This presentation will examine the relations between leadership, communication, decision making and overall crew performance. Implications of these findings for training will be discussed.

Decision Making in Action: Applying Research to Practice

NASA Technical Reports Server (NTRS)

Orasanu, Judith; Hart, Sandra G. (Technical Monitor)

1994-01-01

The importance of decision-making to safety in complex, dynamic environments like mission control centers, aviation, and offshore installations has been well established. NASA-ARC has a program of research dedicated to fostering safe and effective decision-making in the manned spaceflight environment: Because access to spaceflight is limited, environments with similar characteristics, including aviation and nuclear power plants, serve as analogs from which space-relevant data can be gathered and theories developed. Analyses of aviation accidents cite crew judgement and decision making as causes or contributing factors in over half of all accidents. Yet laboratory research on decision making has not proven especially helpful in improving the quality of decisions in these kinds of environments. One reason is that the traditional, analytic decision models are inappropriate to multi-dimensional, high-risk environments, and do not accurately describe what expert human decision makers do when they make decisions that have consequences. A new model of dynamic, naturalistic decision making is offered that may prove useful for improving decision making in complex, isolated, confined and high-risk environments. Based on analyses of crew performance in full-mission simulators and accident reports, features that define effective decision strategies in abnormal or emergency situations have been identified. These include accurate situation assessment (including time and risk assessment), appreciation of the complexity of the problem, sensitivity to constraints on the decision, timeliness of the response, and use of adequate information. More effective crews also manage their workload to provide themselves with time and resources to make good good decisions are appropriate to the demands of the situation. Effective crew decision making and overall performance are mediated by crew communication. Communication contributes to performance because it assures that all crew members have essential information, but it also regulates and coordinates crew actions and is the medium of collective thinking in response to a problem. This presentation will examine the relations between leadership, communication, decision making and overall crew performance. Implications of these findings for training will be discussed.

Sustained Accelerated Idioventricular Rhythm in a Centrifuge-Simulated Suborbital Spaceflight.

PubMed

Suresh, Rahul; Blue, Rebecca S; Mathers, Charles; Castleberry, Tarah L; Vanderploeg, James M

2017-08-01

Hypergravitational exposures during human centrifugation are known to provoke dysrhythmias, including sinus dysrhythmias/tachycardias, premature atrial/ventricular contractions, and even atrial fibrillations or flutter patterns. However, events are generally short-lived and resolve rapidly after cessation of acceleration. This case report describes a prolonged ectopic ventricular rhythm in response to high G exposure. A previously healthy 30-yr-old man voluntarily participated in centrifuge trials as a part of a larger study, experiencing a total of 7 centrifuge runs over 48 h. Day 1 consisted of two +Gz runs (peak +3.5 Gz, run 2) and two +Gx runs (peak +6.0 Gx, run 4). Day 2 consisted of three runs approximating suborbital spaceflight profiles (combined +Gx and +Gz). Hemodynamic data collected included blood pressure, heart rate, and continuous three-lead electrocardiogram. Following the final acceleration exposure of the last Day 2 run (peak +4.5 Gx and +4.0 Gz combined, resultant +6.0 G), during a period of idle resting centrifuge activity (resultant vector +1.4 G), the subject demonstrated a marked change in his three-lead electrocardiogram from normal sinus rhythm to a wide-complex ectopic ventricular rhythm at a rate of 91-95 bpm, consistent with an accelerated idioventricular rhythm (AIVR). This rhythm was sustained for 2 m, 24 s before reversion to normal sinus. The subject reported no adverse symptoms during this time. While prolonged, the dysrhythmia was asymptomatic and self-limited. AIVR is likely a physiological response to acceleration and can be managed conservatively. Vigilance is needed to ensure that AIVR is correctly distinguished from other, malignant rhythms to avoid inappropriate treatment and negative operational impacts.Suresh R, Blue RS, Mathers C, Castleberry TL, Vanderploeg JM. Sustained accelerated idioventricular rhythm in a centrifuge-simulated suborbital spaceflight. Aerosp Med Hum Perform. 2017; 88(8):789-793.

Historical Review of Lower Body Negative Pressure Research in Space Medicine.

PubMed

Campbell, Mark R; Charles, John B

2015-07-01

Cephalad redistribution of intravascular and extravascular fluid occurs as a result of weightlessness during spaceflight. This provokes cardiovascular, cardiopulmonary, and autonomic nervous system responses. The resulting altered functional state can result in orthostatic hypotension and intolerance upon landing and return to a gravity environment. In-flight lower body negative pressure (LBNP) transiently restores normal body fluid distribution. Early in the U.S. space program, LBNP was devised as a way to test for orthostatic intolerance. With the development of the Skylab Program and longer duration spaceflight, it was realized that it could provide a method of monitoring orthostatic intolerance in flight and predicting the post-landing orthostatic response. LBNP was also investigated not only as an in-flight cardiovascular orthostatic stress test, but also as a countermeasure to cardiovascular deconditioning on Soviet space stations, Skylab, and the Shuttle. It is still being used by the Russian program on the International Space Station as an end-of-flight countermeasure.

Modeling Operations Costs for Human Exploration Architectures

NASA Technical Reports Server (NTRS)

Shishko, Robert

2013-01-01

Operations and support (O&S) costs for human spaceflight have not received the same attention in the cost estimating community as have development costs. This is unfortunate as O&S costs typically comprise a majority of life-cycle costs (LCC) in such programs as the International Space Station (ISS) and the now-cancelled Constellation Program. Recognizing this, the Constellation Program and NASA HQs supported the development of an O&S cost model specifically for human spaceflight. This model, known as the Exploration Architectures Operations Cost Model (ExAOCM), provided the operations cost estimates for a variety of alternative human missions to the moon, Mars, and Near-Earth Objects (NEOs) in architectural studies. ExAOCM is philosophically based on the DoD Architecture Framework (DoDAF) concepts of operational nodes, systems, operational functions, and milestones. This paper presents some of the historical background surrounding the development of the model, and discusses the underlying structure, its unusual user interface, and lastly, previous examples of its use in the aforementioned architectural studies.

Mir 18 Crew Insignia

NASA Image and Video Library

1994-07-07

S94-36965 (20 Sept 1994) --- The rising sun signifies the dawn of a new era of human Spaceflight, the first phase of the U.S./Russian space partnership, Shuttle-Mir. Mir is shown in its proposed final on orbit configuration. The Shuttle is shown in a generic tunnel/Spacehab configuration. The Shuttle-Mir combination, docked to acknowledge the union of the two space programs, orbits over an Earth devoid of any definable features or political borders to emphasize Earth as the home planet for all humanity. The individual stars near the Shuttle and the Mir station represent the previous individual accomplishments of Russia's space program and that of the U.S. The binary star is a tribute to the previous U.S.-Russian joint human Spaceflight program, the Apollo-Soyuz Test Project. The flags of the two nations are symbolized by flowing ribbons of the national colors interwoven in space to represent the two nations joint exploration of space. NASA SHUTTLE and PKA MNP are shown in the stylized logo fonts of the two agencies that are conducting this program.

Operational Aspects of Space Radiation Analysis

NASA Technical Reports Server (NTRS)

Weyland, M. D.; Johnson, A. S.; Semones, E. J.; Shelfer, T.; Dardano, C.; Lin, T.; Zapp, N. E.; Rutledge, R.; George, T.

2005-01-01

Minimizing astronaut's short and long-term medical risks arising from exposure to ionizing radiation during space missions is a major concern for NASA's manned spaceflight program, particularly exploration missions. For ethical and legal reasons, NASA follows the "as low as reasonably achievable" (ALARA) principal in managing astronaut's radiation exposures. One implementation of ALARA is the response to space weather events. Of particular concern are energetic solar particle events, and in low Earth orbit (LEO), electron belt enhancements. To properly respond to these events, NASA's Space Radiation Analysis Group (SRAG), in partnership with the NOAA Space Environment Center (SEC), provides continuous flight support during U.S. manned missions. In this partnership, SEC compiles space weather data from numerous ground and space based assets and makes it available in near real-time to SRAG (along with alerts and forecasts), who in turn uses these data as input to models to calculate estimates of the resulting exposure to astronauts. These calculations and vehicle instrument data form the basis for real-time recommendations to flight management. It is also important to implement ALARA during the design phase. In order to appropriately weigh the risks associated with various shielding and vehicle configuration concepts, the expected environment must be adequately characterized for nominal and worst case scenarios for that portion of the solar cycle and point in space. Even with the best shielding concepts and materials in place (unlikely), there will be numerous occasions where the crew is at greater risk due to being in a lower shielded environment (short term transit or lower shielded vehicles, EVAs), so that accurate space weather forecasts and nowcasts, of particles at the relevant energies, will be crucial to protecting crew health and safety.

Quiet, Efficient Fans for Spaceflight: An Overview of NASA's Technology Development Plan

NASA Technical Reports Server (NTRS)

Koch, L. Danielle

2010-01-01

A Technology Development Plan to improve the aerodynamic and acoustic performance of spaceflight fans has been submitted to NASA s Exploration Technology Development Program. The plan describes a research program intended to make broader use of the technology developed at NASA Glenn to increase the efficiency and reduce the noise of aircraft engine fans. The goal is to develop a set of well-characterized government-owned fans nominally suited for spacecraft ventilation and cooling systems. NASA s Exploration Life Support community will identify design point conditions for the fans in this study. Computational Fluid Dynamics codes will be used in the design and analysis process. The fans will be built and used in a series of tests. Data from aerodynamic and acoustic performance tests will be used to validate performance predictions. These performance maps will also be entered into a database to help spaceflight fan system developers make informed design choices. Velocity measurements downstream of fan rotor blades and stator vanes will also be collected and used for code validation. Details of the fan design, analysis, and testing will be publicly reported. With access to fan geometry and test data, the small fan industry can independently evaluate design and analysis methods and work towards improvement.

A NASA Applied Spaceflight Environments Office Concept

NASA Technical Reports Server (NTRS)

Spann, James F.; Edwards, David L.; Burns, Howard D.; Xapsos, Mike

2011-01-01

The National Aeronautics and Space Administration (NASA) is launching a bold and ambitious new space initiative. A significant part of this new initiative includes exploration of new worlds, the development of more innovative technologies, and expansion our presence in the solar system. A common theme to this initiative is the exploration of space beyond Low Earth Orbit (LEO). As currently organized, NASA does not have an Agency-level office that provides coordination of space environment research and development. This has contributed to the formation of a gap between spaceflight environments knowledge and the application of this knowledge for multi-program use and for use outside NASA. This paper outlines a concept to establish a NASA-level Applied Spaceflight Environments (ASE) office that will provide coordination and funding for sustained multi-program support in three technical areas that have demonstrated these needs through customer requests. These technical areas are natural environments characterization and modeling, materials and systems analysis and test, and operational space environments modeling. Additionally the ASE office will serve as an entry point of contact for external users who wish to take advantage of data and assets associated with space environments, including space weather. This paper will establish the need for the ASE, discuss a concept for organizational structure and outline the scope in the three technical areas.

Microbial Contamination in the Spacecraft

NASA Technical Reports Server (NTRS)

Pierson, Duane L.

2001-01-01

Spacecraft and space habitats supporting human exploration contain a diverse population of microorganisms. Microorganisms may threaten human habitation in many ways that directly or indirectly impact the health, safety, or performance of astronauts. The ability to produce and maintain spacecraft and space stations with environments suitable for human habitation has been established over 40 years of human spaceflight. An extensive database of environmental microbiological parameters has been provided for short-term (< 20 days) spaceflight by more than 100 missions aboard the Space Shuttle. The NASA Mir Program provided similar data for long-duration missions. Interestingly, the major bacterial and fungal species found in the Space Shuttle are similar to those encountered in the nearly 15-year-old Mir. Lessons learned from both the US and Russian space programs have been incorporated into the habitability plan for the International Space Station. The focus is on preventive measures developed for spacecraft, cargo, and crews. On-orbit regular housekeeping practices complete with visual inspections are essential, along with microbiological monitoring. Risks associated with extended stays on the Moon or a Mars exploration mission will be much greater than previous experiences because of additional unknown variables. The current knowledge base is insufficient for exploration missions, and research is essential to understand the effects of spaceflight on biological functions and population dynamics of microorganisms in spacecraft.

Kosmo's Farewell Advice

NASA Technical Reports Server (NTRS)

Kosmo, Joe; Ross, Amy

2012-01-01

Joe Kosmo shared some final words and advice for his teammates in the Spacesuit and Crew Survival Systems Branch (EC5) and the Crew and Thermal Systems Division (CTSD (EC)) upon his retirement. He knew nothing about spacesuits when he started working for NASA in 1961, but neither did anyone else. He summed up the best lessons learned during his 50 years of developing U.S. spacesuits and encouraged the next generation s space industry workers to challenge what they hear and decide what is right. Topics include and oral history of early NASA manned flights by Richard S. Johnston, U.S. human spaceflight chronology, a history of advanced EVA project funding, and a discussion of NASA's innovative spirit.

STS-64 crew prepare to de-orbit and complete extended mission

NASA Image and Video Library

1994-09-15

STS064-06-028 (9-20 Sept. 1994) --- On the space shuttle Discovery's flight deck, two thirds of the crew prepare for one of four hard efforts (in a two-day period) to de-orbit and complete the extended spaceflight. Manning the commander's station and wearing one of the launch and entry suits is astronaut Richard N. Richards, STS-64 mission commander. At the pilot's station is astronaut Susan J. Helms, mission specialist. Astronaut L. Blaine Hammond, pilot, is at left foreground, and astronaut Carl J. Meade, mission specialist, is at left background in the hatch leading to the middeck. Photo credit: NASA or National Aeronautics and Space Administration

Aeronautics and space report of the President, 1983 activities

NASA Technical Reports Server (NTRS)

1984-01-01

Achievements in communication; space science; space transportation; aeronautics; and Earth resources and environment are summarized. Activities of the various Federal agencies and cooperation with NASA in these areas are described. The Presidential policy announcement on the endorsement of commercial operation of expendable launch vehicles is included. Tables show, the space activities budget; a historical budget summary, U.S. space launch vehicles; U.S. and Soviet manned spaceflights, 1961 to 1983; U.S. launched space probes, 1975 to 1983; U.S. launched scientific and applications satellites, 1978 to 1983; the U.S. spacecraft record; the world record of space launches successful in attaining Earth orbit or beyond; and successful U.S. launchings for 1983.

Anabolic and Catabolic Signaling Pathways in mouse Longissimus Dorsi after 30-day BION-M1 Spaceflight and Subsequent Recovery

NASA Astrophysics Data System (ADS)

Mirzoev, Timur; Blottner, Dieter; Shenkman, Boris; Lomonosova, Yulia; Vilchinskaya, Natalia; Nemirovskaya, Tatiana; Salanova, Michele

The aim of the study was to analyze some of the key markers regulating anabolic and catabolic processes in mouse m. longissimus dorsi, an important back muscle system for trunk stabilization, following 30-day spaceflight and 8-day recovery period. C57/black mice were divided into 3 groups: 1) Vivarium Control (n=7), 2) Flight (n=5), 3) Recovery (n=5). The experiment was carried out in accordance with the rules of biomedical ethics certified by the Russian Academy of Sciences Committee on Bioethics. Using Western-blotting analysis we determined the content of IRS-1, p-AMPK, MURF-1 and eEF2 in m. longissimus dorsi. The content of IRS-1 in mice m. longissimus dorsi after the 30-day flight did not differ from the control group, however, in the Recovery group IRS-1 level was 80% higher (p<0.05) as compared to Control. Phospho-AMPK content remained unchanged. In the Recovery group there was an increase of eEF2 by 75% compared to the Control (p<0.05). After spaceflight MuRF-1 content was increased more than 2 times compared to the control animals. Thus, our findings showed that the work of the IRS-1 - dependent signaling pathway is only active in the recovery period. The content of the ubiquitin-ligase MURF-1 that takes parts in degrading myosin heavy chain was increased after the spaceflight, however, after 8-day recovery period MURF-1 level did not exceed the control indicating normalization of protein degradation in m. longissimus dorsi. The work was supported by the program of basic research of RAS and Federal Space Program of Russia for the period of 2006-2015.

Risk Management in the Human Spaceflight Program

NASA Technical Reports Server (NTRS)

Hoffman, William

2009-01-01

The contents include:1) NASA Mission and Organization; 2) Major Mission Failures and Causes; 3) Cultural Changes Resulting from Failures; 3) Safety at NASA Today; 4) Best Safety Practices; 5) Safety Challenges; and 6) Future Commitment.

Legacy of Biomedical Research During the Space Shuttle Program

NASA Technical Reports Server (NTRS)

Hayes, Judith C.

2011-01-01

The Space Shuttle Program provided many opportunities to study the role of spaceflight on human life for over 30 years and represented the longest and largest US human spaceflight program. Outcomes of the research were understanding the effect of spaceflight on human physiology and performance, countermeasures, operational protocols, and hardware. The Shuttle flights were relatively short, < 16 days and routinely had 4 to 6 crewmembers for a total of 135 flights. Biomedical research was conducted on the Space Shuttle using various vehicle resources. Specially constructed pressurized laboratories called Spacelab and SPACEHAB housed many laboratory instruments to accomplish experiments in the Shuttle s large payload bay. In addition to these laboratory flights, nearly every mission had dedicated human life science research experiments conducted in the Shuttle middeck. Most Shuttle astronauts participated in some life sciences research experiments either as test subjects or test operators. While middeck experiments resulted in a low sample per mission compared to many Earth-based studies, this participation allowed investigators to have repetition of tests over the years on successive Shuttle flights. In addition, as a prelude to the International Space Station (ISS), NASA used the Space Shuttle as a platform for assessing future ISS hardware systems and procedures. The purpose of this panel is to provide an understanding of science integration activities required to implement Shuttle research, review biomedical research, characterize countermeasures developed for Shuttle and ISS as well as discuss lessons learned that may support commercial crew endeavors. Panel topics include research integration, cardiovascular physiology, neurosciences, skeletal muscle, and exercise physiology. Learning Objective: The panel provides an overview from the Space Shuttle Program regarding research integration, scientific results, lessons learned from biomedical research and countermeasure development.

MCNPX Cosmic Ray Shielding Calculations with the NORMAN Phantom Model

NASA Technical Reports Server (NTRS)

James, Michael R.; Durkee, Joe W.; McKinney, Gregg; Singleterry Robert

2008-01-01

The United States is planning manned lunar and interplanetary missions in the coming years. Shielding from cosmic rays is a critical aspect of manned spaceflight. These ventures will present exposure issues involving the interplanetary Galactic Cosmic Ray (GCR) environment. GCRs are comprised primarily of protons (approx.84.5%) and alpha-particles (approx.14.7%), while the remainder is comprised of massive, highly energetic nuclei. The National Aeronautics and Space Administration (NASA) Langley Research Center (LaRC) has commissioned a joint study with Los Alamos National Laboratory (LANL) to investigate the interaction of the GCR environment with humans using high-fidelity, state-of-the-art computer simulations. The simulations involve shielding and dose calculations in order to assess radiation effects in various organs. The simulations are being conducted using high-resolution voxel-phantom models and the MCNPX[1] Monte Carlo radiation-transport code. Recent advances in MCNPX physics packages now enable simulated transport over 2200 types of ions of widely varying energies in large, intricate geometries. We report here initial results obtained using a GCR spectrum and a NORMAN[3] phantom.

Space Weather Status for Exploration Radiation Protection

NASA Technical Reports Server (NTRS)

Fry, Dan J.; Lee, Kerry; Zapp, Neal; Barzilla, Janet; Dunegan, Audrey; Johnson, Steve; Stoffle, Nicholas

2011-01-01

Management of crew exposure to radiation is a major concern for manned spaceflight and will be even more important for the modern concept of longer-duration exploration. The inherent protection afforded to astronauts by the magnetic field of the Earth in Low Earth Orbit (LEO) makes operations on the space shuttle or space station very different from operations during an exploration mission. In order to experience significant radiation-derived Loss of Mission (LOM) or Loss of Crew (LOC) risk for LEO operations, one is almost driven to dictate extreme duration or to dictate an extreme sequence of solar activity. Outside of the geo-magnetosphere, however, this scenario changes dramatically. Exposures to the same event on the ISS and in free space, for example, may differ by orders of magnitude. This change in magnitude, coupled with the logistical constraints present in implementing any practical operational mitigation make situational awareness with regard to space weather a limiting factor for the ability to conduct exploration operations. We present a current status of developing operational concepts for manned exploration and expectations for asset viability and available predictive and characterization toolsets.

Review of the results from the International C. elegans first experiment (ICE-FIRST)

PubMed Central

Adenle, A.A.; Johnsen, B.; Szewczyk, N.J.

2009-01-01

In an effort to speed the rate of discovery in space biology and medicine NASA introduced the now defunct model specimen program. Four nations applied this approach with C. elegans in the ICE-FIRST experiment. Here we review the standardized culturing as well as the investigation of muscle adaptation, space biology radiation, and gene expression in response to spaceflight. Muscle studies demonstrated that decreased expression of myogenic transcription factors underlie the decreased expression of myosin seen in flight, a response that would appear to be evolutionarily conserved. Radiation studies demonstrated that radiation damaged cells should be able to be removed via apoptosis in flight, and that C. elegans can be employed as a biological accumulating dosimeter. Lastly, ICE-FIRST gave us our first glimpse at the genomic response to spaceflight, suggesting that altered Insulin and/or TGF-beta signaling in-flight may underlie many of the biological changes seen in response to spaceflight. The fact that the results obtained with C. elegans appear to have strong similarities in human beings suggests that not only will C. elegans prove an invaluable model for understanding the fundamental biological changes seen during spaceflight but that it may also be invaluable for understanding those changes associated with human health concerns in space. PMID:20161164

Skeletal health in long-duration astronauts: nature, assessment, and management recommendations from the NASA Bone Summit.

PubMed

Orwoll, Eric S; Adler, Robert A; Amin, Shreyasee; Binkley, Neil; Lewiecki, E Michael; Petak, Steven M; Shapses, Sue A; Sinaki, Mehrsheed; Watts, Nelson B; Sibonga, Jean D

2013-06-01

Concern about the risk of bone loss in astronauts as a result of prolonged exposure to microgravity prompted the National Aeronautics and Space Administration to convene a Bone Summit with a panel of experts at the Johnson Space Center to review the medical data and research evidence from astronauts who have had prolonged exposure to spaceflight. Data were reviewed from 35 astronauts who had served on spaceflight missions lasting between 120 and 180 days with attention focused on astronauts who (1) were repeat fliers on long-duration missions, (2) were users of an advanced resistive exercise device (ARED), (3) were scanned by quantitative computed tomography (QCT) at the hip, (4) had hip bone strength estimated by finite element modeling, or (5) had lost >10% of areal bone mineral density (aBMD) at the hip or lumbar spine as measured by dual-energy X-ray absorptiometry (DXA). Because of the limitations of DXA in describing the effects of spaceflight on bone strength, the panel recommended that the U.S. space program use QCT and finite element modeling to further study the unique effects of spaceflight (and recovery) on bone health in order to better inform clinical decisions. Copyright © 2013 American Society for Bone and Mineral Research.

Recommended Methods for Monitoring Skeletal Health in Astronauts to Distinguish Specific Effects of Prolonged Spaceflight

NASA Technical Reports Server (NTRS)

Vasadi, Lukas J.; Spector, Elizabeth R.; Smith, Scott A.; Yardley, Gregory L.; Evans, Harlan J.; Sibonga, Jean D.

2016-01-01

NASA uses areal bone mineral density (aBMD) by dual-energy X-ray absorptiometry (DXA) to monitor skeletal health in astronauts after typical 180-day spaceflights. The osteoporosis field and NASA, however, recognize the insufficiency of DXA aBMD as a sole surrogate for fracture risk. This is an even greater concern for NASA as it attempts to expand fracture risk assessment in astronauts, given the complicated nature of spaceflight-induced bone changes and the fact that multiple 1-year missions are planned. In the past decade, emerging analyses for additional surrogates have been tested in clinical trials; the potential use of these technologies to monitor the biomechanical integrity of the astronaut skeleton will be presented. OVERVIEW: An advisory panel of osteoporosis policy-makers provided NASA with an evidence-based assessment of astronaut biomedical and research data. The panel concluded that spaceflight and terrestrial bone loss have significant differences and certain factors may predispose astronauts to premature fractures. Based on these concerns, a proposed surveillance program is presented which a) uses Quantitative Computed Tomography (QCT) scans of the hip to monitor the recovery of spaceflight-induced deficits in trabecular BMD by 2 years after return, b) develops Finite Element Models [FEM] of QCT data to evaluate spaceflight effect on calculated hip bone strength and c) generates Trabecular Bone Score [TBS] from serial DXA scans of the lumbar spine to evaluate the effect of age, spaceflight and countermeasures on this novel index of bone microarchitecture. SIGNIFICANCE: DXA aBMD is a widely-applied, evidence-based predictor for fractures but not applicable as a fracture surrogate for premenopausal females and males <50 years. Its inability to detect structural parameters is a limitation for assessing changes in bone integrity with and without countermeasures. Collective use of aBMD, TBS, QCT, and FEM analysis for astronaut surveillance could accommodate NASA's aggressive schedule for risk definition and inform a NASA-developed model which assesses the probability of overloading bones during mechanically-loaded mission tasks and possibly for physical activities after return to Earth.

Alterations in TNF- and IL-related gene expression in space-flown WI38 human fibroblasts

NASA Technical Reports Server (NTRS)

Semov, Alexandre; Semova, Nathalia; Lacelle, Chantale; Marcotte, Richard; Petroulakis, Emmanuel; Proestou, Gregory; Wang, Eugenia

2002-01-01

Spaceflight, just like aging, causes profound changes in musculoskeletal parameters, which result in decreased bone density and muscular weakness. As these conditions decrease our ability to conduct long-term manned space missions, and increase bone frailty in the elderly, the identification of genes responsible for the apparition of these physiological changes will be of great benefit. Thus, we developed and implemented a new microarray approach to investigate the changes in normal WI38 human fibroblast gene expression that arise as a consequence of space flight. Using our microarray, we identified changes in the level of expression of 10 genes, belonging to either the tumor necrosis factor- (TNF) or interleukin- (IL) related gene families in fibroblasts when WI38 cells exposed to microgravity during the STS-93 Space Shuttle mission were compared with ground controls. The genes included two ligands from the TNF superfamily, TWEAK and TNFSF15; two TNF receptor-associated proteins, NSMAF and PTPN13; three TNF-inducible genes, ABC50, PTX3, and SCYA13; TNF-alpha converting enzyme, IL-1 receptor antagonist, and IL-15 receptor alpha chain. Most of these are involved in either the regulation of bone density, and as such the development of spaceflight osteopenia, or in the development of proinflammatory status.

Human and Robotic Space Mission Use Cases for High-Performance Spaceflight Computing

NASA Technical Reports Server (NTRS)

Some, Raphael; Doyle, Richard; Bergman, Larry; Whitaker, William; Powell, Wesley; Johnson, Michael; Goforth, Montgomery; Lowry, Michael

2013-01-01

Spaceflight computing is a key resource in NASA space missions and a core determining factor of spacecraft capability, with ripple effects throughout the spacecraft, end-to-end system, and mission. Onboard computing can be aptly viewed as a "technology multiplier" in that advances provide direct dramatic improvements in flight functions and capabilities across the NASA mission classes, and enable new flight capabilities and mission scenarios, increasing science and exploration return. Space-qualified computing technology, however, has not advanced significantly in well over ten years and the current state of the practice fails to meet the near- to mid-term needs of NASA missions. Recognizing this gap, the NASA Game Changing Development Program (GCDP), under the auspices of the NASA Space Technology Mission Directorate, commissioned a study on space-based computing needs, looking out 15-20 years. The study resulted in a recommendation to pursue high-performance spaceflight computing (HPSC) for next-generation missions, and a decision to partner with the Air Force Research Lab (AFRL) in this development.

Results of space experiment program "Interferon". II. Influence of spaceflight conditions on the activity of interferon preparations and interferon inducers ("Interferon II").

PubMed

Tálas, M; Bátkai, L; Stöger, I; Nagy, K; Hiros, L; Konstantinova, I; Kozharinov, V

1983-01-01

The influence of spaceflight conditions on the biological activity of HuIFN-alpha preparations (lyophilized, in solution and in ointment) and interferon inducers was studied. In antiviral activity no difference was observed between the samples kept aboard the spaceship and the controls kept under ground conditions. The interferon inducers poly I:C, poly G:C and gossipol placed in the space laboratory for 7 days maintained their interferon-inducing capacity. The circulating interferon level in mice was the same irrespective of the induction being performed with flight or ground-control samples of inducers.

Sex-Specific Effects of Unpredictable Variable Prenatal Stress: Implications for Mammalian Developmental Programming During Spaceflight

NASA Technical Reports Server (NTRS)

Talyansky, Y.; Moyer, E. L.; Oijala, E.; Baer, L. A.; Ronca, A. E.

2016-01-01

During adaptation to the microgravity environment, adult mammals experience stress mediated by the Hypothalamic-Pituitary-Adrenal axis. In our previous studies of pregnant rats exposed to 2-g hypergravity via centrifugation, we reported decreased corticosterone and increased body mass and leptin in adult male, but not female, offspring. In this study, we utilized Unpredictable Variable Prenatal Stress to simulate the stressors of spaceflight by exposing dams to different stressors. Stress response modulation occurs via both positive and negative feedback in the hypothalamus, anterior pituitary gland, and adrenal cortex resulting in the differential release of corticosterone (CORT), a murine analog to human cortisol.

Apollo experience report: Development flight instrumentation. [telemetry equipment for space flight test program

NASA Technical Reports Server (NTRS)

Farmer, N. B.

1974-01-01

Development flight instrumentation was delivered for 25 Apollo vehicles as Government-furnished equipment. The problems and philosophies of an activity that was concerned with supplying telemetry equipment to a space-flight test program are discussed. Equipment delivery dates, system-design details, and flight-performance information for each mission also are included.

Evidence Report: Risk of Hypobaric Hypoxia from the Exploration Atmosphere

NASA Technical Reports Server (NTRS)

Norcross, Jason R.; Conkin, Johnny; Wessel, James H., III; Norsk, Peter; Law, Jennifer; Arias, Diana; Goodwin, Tom; Crucian, Brian; Whitmire, Alexandra; Bloomberg, Jacob;

A Martian Chronicle.

ERIC Educational Resources Information Center

Craig, Doug

1990-01-01

The development of a spaceflight simulation program as part of a research and development course is described. Topics such as space exploration, design, propulsion, aerodynamics of space craft, robotics, communication, construction, medicine, lasers, hydroponics, geology, chemistry, and space physiology are emphasized. (KR)

JCL Implementation On A Human Spaceflight Program

NASA Technical Reports Server (NTRS)

Kulpa, Vyga; Karpowich, Mike; Abel, Diana; Archiable, Wes; Carson, William

2013-01-01

Joint Confidence Level (JCL) analysis focuses on the integration of traditionally stove-piped programmatic components (schedule, cost and risk) to establish projected resource and schedule requirements at various confidence levels and to identify programmatic cost and schedule risk drivers. SLS Program consists of multiple Prime Contractors managed by independent SLS Elements which are integrated using SE&I and Program Management. SLS further integrates with GSDO and MPCV through ESD integrated working groups.

Commercial Crew Program and the Safety Technical Review Board

NASA Technical Reports Server (NTRS)

Mullen, Macy

2016-01-01

The Commercial Crew Program (CCP) is unique to any other program office at NASA. After the agency suffered devastating budget cuts and the Shuttle Program retired, the U.S. gave up its human spaceflight capabilities. Since 2011 the U.S. has been dependent on Russia to transport American astronauts and cargo to the International Space Station (ISS) and back. NASA adapted and formed CCP, which gives private, domestic, aerospace companies unprecedented reign over America's next ride to space. The program began back in 2010 with 5 companies and is now in the final phase of certification with 2 commercial partners. The Commercial Crew Program is made up of 7 divisions, each working rigorously with the commercial providers to complete the certification phase. One of these 7 divisions is Systems Engineering and Integration (SE&I) which is partly comprised of the Safety Technical Review Board (STRB). The STRB is primarily concerned with mitigating improbable, but catastrophic hazards. It does this by identifying, managing, and tracking these hazards in reports. With the STRB being in SE&I, it significantly contributes to the overall certification of the partners' vehicles. After the partners receive agency certification approval, they will have the capability to provide the U.S. with a reliable, safe, and cost-effective means of human spaceflight and cargo transport to the ISS and back.

The Mercury-Redstone Program

NASA Technical Reports Server (NTRS)

Hammack, Jerome B.; Heberlig, Jack C.

1961-01-01

The Mercury-Redstone program is reviewed as to its intended mission and its main results. The progressive results of unmanned, animal, and manned flights of this over-all Project Mercury ballistic training program are presented. A technical description of the major spacecraft systems is presented with some analysis of flight performance. Performance of the spacecraft with and without pilot input is discussed. The influence of the astronaut as an operating link in the over-all system is presented, and relative difficulties of manned versus unmanned flight are briefly commented upon. The program provided information on man as an integral part of a space flight system, demonstrating that man can assume a primary role in space as he does in other realms of flight. The Mercury-Redstone program demonstrated that the Mercury spacecraft was capable of manned space flight, and succeeded in partially qualifying the spacecraft for orbital flight.

Looking Backward, Looking Forward: Forty Years of US Human Spaceflight Symposium

NASA Technical Reports Server (NTRS)

Garber, Stephen J. (Editor); Launius, Roger (Technical Monitor)

2001-01-01

This symposium reflects on forty years of U.S. Human Spaceflight, its role over the next four decades and beyond. The topics include: 1) Perspectives on the Past Forty Years of Human Spaceflight; 2) The Experience of Spaceflight; 3) Perspectives on the Next Forty Years of Human Spaceflight; and 4) The International Space Station and the Future of Human Spaceflight.

An Apple II Implementation of Man-Mod Manpower Planning Model.

DTIC Science & Technology

1982-03-01

next page. It is highly recommended, to prevent the loss of data, that the user save the data at this point. If Choice (1 ), yes, is selected, the...approximately 30 seconds, but will clear and reload memory preventing any inadvertent memory changes which might cause program interruptions or erroneous cal... prgram . 70 MAN-MOD/PROGRAM (PROGRAM LISTING) 1000 REM MAN-MOD/PROGRAM PROGRAM: "FOR" IS IN QUOTES IN LINES 1004,10518,10520,10524,10526,10528,1072

Disability Evaluation System Analysis and Research Annual Report 2017

DTIC Science & Technology

2017-11-20

Amanda L. Kelley, MPH Program Manager, AMSARA Deputy Program Manager, AMSARA Contractor, ManTech Health Contractor, ManTech Health Christine...Toolin, MS Cordie K. Campbell, MPH Public Health Analyst, AMSARA Public Health Analyst, AMSARA Contractor, ManTech Health Contractor...ManTech Health Preventive Medicine Branch Walter Reed Army Institute of Research 503 Robert Grant Road, Forest Glen Annex Silver

Astronaut medical selection during the shuttle era: 1981-2011.

PubMed

Johnston, Smith L; Blue, Rebecca S; Jennings, Richard T; Tarver, William J; Gray, Gary W

2014-08-01

U.S. astronauts undergo extensive job-related screening and medical examinations prior to selection in order to identify candidates optimally suited for careers in spaceflight. Screening medical standards evolved over many years and after extensive spaceflight experience. These standards assess health-related risks for each astronaut candidate, minimizing the potential for medical impact on future mission success. This document discusses the evolution of the Shuttle-era medical selection standards and the most common reasons for medical dis-qualification of applicants. Data for astronaut candidate finalists were compiled from medical records and NASA archives from the period of 1978 to 2004 and were retrospectively reviewed for medically disqualifying conditions. During Shuttle selection cycles, a total of 372 applicants were disqualified due to 425 medical concerns. The most common disqualifying conditions included visual, cardiovascular, psychiatric, and behavioral disorders. During this time period, three major expert panel reviews resulted in refinements and alterations to selection standards for future cycles. Shuttle-era screening, testing, and specialist evaluations evolved through periodic expert reviews, evidence-based medicine, and astronaut medical care experience. The Shuttle medical program contributed to the development and implementation of NASA and international standards, longitudinal data collection, improved medical care, and occupational surveillance models. The lessons learned from the Shuttle program serve as the basis for medical selection for the ISS, exploration-class missions, and for those expected to participate in commercial spaceflight.

Human Spaceflight and American Society: The Record So Far

NASA Astrophysics Data System (ADS)

Murray, Charles

2002-01-01

These remarks give me an excuse to revisit a world that Catherine Cox and I had a chance to live in vicariously from 1986 to 1989 when we were researching and writing about Project Apollo. As I thought about it, I realized that actually very few people in this audience have had a chance to live in that world, either vicariously or for real. For most people today, NASA's human spaceflight program is the Shuttle. The NASA you know is an extremely large bureaucracy. The Apollo you know is a historical event. So to kick off today's presentations, I want to be the "Voice of Christmas Past." If we want to think about what is possible for human spaceflight as part of America's future, it is essential to understand how NASA people understood "possible" during the Apollo era. It is also important to understand that the way NASA functioned during the Apollo Program was wildly different from the way NASA functions now. In fact-and I say this with all due respect to the current NASA team members who are doing fine work-the race to the Moon was not really a race against the Russians; it was a race to see if we could get to the Moon before NASA became a bureaucracy, and we won. But the lessons of that experience should be ones that we still have at the front of our minds.

Retention and application of Skylab experiences to future programs. [a postflight review of technical programs.

NASA Technical Reports Server (NTRS)

Gillespie, V. G.; Kelly, R. O.

1974-01-01

The problems encountered and special techniques and procedures developed on the Skylab program are described along with the experiences and practical benefits obtained for dissemination and use on future programs. Three major topics are discussed: electrical problems, mechanical problems, and special techniques. Special techniques and procedures are identified that were either developed or refined during the Skylab program. These techniques and procedures came from all manufacturing and test phases of the Skylab program and include both flight and GSE items from component level to sophisticated spaceflight systems.

iss050e056553

NASA Image and Video Library

2017-03-09

iss050e056553 (03/09/2017) --- NASA astronaut Peggy Whitson unloads spaceflight hardware delivered on SpaceX CRS-10 that was built as part of the NASA High School Students United with NASA to Create Hardware (HUNCH) program. Students in the HUNCH program receive valuable experience creating goods for NASA from hardware to the culinary arts, while NASA receives the creativity of the High School students.

Geometry and gravity influences on strength capability

NASA Technical Reports Server (NTRS)

Poliner, Jeffrey; Wilmington, Robert P.; Klute, Glenn K.

1994-01-01

Strength, defined as the capability of an individual to produce an external force, is one of the most important determining characteristics of human performance. Knowledge of strength capabilities of a group of individuals can be applied to designing equipment and workplaces, planning procedures and tasks, and training individuals. In the manned space program, with the high risk and cost associated with spaceflight, information pertaining to human performance is important to ensuring mission success and safety. Knowledge of individual's strength capabilities in weightlessness is of interest within many areas of NASA, including workplace design, tool development, and mission planning. The weightless environment of space places the human body in a completely different context. Astronauts perform a variety of manual tasks while in orbit. Their ability to perform these tasks is partly determined by their strength capability as demanded by that particular task. Thus, an important step in task planning, development, and evaluation is to determine the ability of the humans performing it. This can be accomplished by utilizing quantitative techniques to develop a database of human strength capabilities in weightlessness. Furthermore, if strength characteristics are known, equipment and tools can be built to optimize the operators' performance. This study examined strength in performing a simple task, specifically, using a tool to apply a torque to a fixture.

A modular, programmable measurement system for physiological and spaceflight applications

NASA Technical Reports Server (NTRS)

Hines, John W.; Ricks, Robert D.; Miles, Christopher J.

1993-01-01

The NASA-Ames Sensors 2000! Program has developed a small, compact, modular, programmable, sensor signal conditioning and measurement system, initially targeted for Life Sciences Spaceflight Programs. The system consists of a twelve-slot, multi-layer, distributed function backplane, a digital microcontroller/memory subsystem, conditioned and isolated power supplies, and six application-specific, physiological signal conditioners. Each signal condition is capable of being programmed for gains, offsets, calibration and operate modes, and, in some cases, selectable outputs and functional modes. Presently, the system has the capability for measuring ECG, EMG, EEG, Temperature, Respiration, Pressure, Force, and Acceleration parameters, in physiological ranges. The measurement system makes heavy use of surface-mount packaging technology, resulting in plug in modules sized 125x55 mm. The complete 12-slot system is contained within a volume of 220x150x70mm. The system's capabilities extend well beyond the specific objectives of NASA programs. Indeed, the potential commercial uses of the technology are virtually limitless. In addition to applications in medical and biomedical sensing, the system might also be used in process control situations, in clinical or research environments, in general instrumentation systems, factory processing, or any other applications where high quality measurements are required.

A modular, programmable measurement system for physiological and spaceflight applications

NASA Astrophysics Data System (ADS)

Hines, John W.; Ricks, Robert D.; Miles, Christopher J.

1993-02-01

The NASA-Ames Sensors 2000] Program has developed a small, compact, modular, programmable, sensor signal conditioning and measurement system, initially targeted for Life Sciences Spaceflight Programs. The system consists of a twelve-slot, multi-layer, distributed function backplane, a digital microcontroller/memory subsystem, conditioned and isolated power supplies, and six application-specific, physiological signal conditioners. Each signal condition is capable of being programmed for gains, offsets, calibration and operate modes, and, in some cases, selectable outputs and functional modes. Presently, the system has the capability for measuring ECG, EMG, EEG, Temperature, Respiration, Pressure, Force, and Acceleration parameters, in physiological ranges. The measurement system makes heavy use of surface-mount packaging technology, resulting in plug in modules sized 125x55 mm. The complete 12-slot system is contained within a volume of 220x150x70mm. The system's capabilities extend well beyond the specific objectives of NASA programs. Indeed, the potential commercial uses of the technology are virtually limitless. In addition to applications in medical and biomedical sensing, the system might also be used in process control situations, in clinical or research environments, in general instrumentation systems, factory processing, or any other applications where high quality measurements are required.

Fire safety design considerations for advanced space vehicles

NASA Technical Reports Server (NTRS)

1988-01-01

The desire to understand and explore space has driven man to overcome the confines of the Earth's atmosphere and accept the challenge of spaceflight. With our increasing ability to travel, work, and explore in space comes a need for a better understanding of the hazards in this relatively new endeavor. One of the most important and immediate needs is to be able to predict the ignition, spread, and growth of fire on board spacecraft. Fire safety aboard spacecraft has always been a concern; however, with the increasing number and duration of proposed missions, it is imperative that the spacecraft be designed with a solid understanding of fire hazards, insuring that all risks have been minimized and extinguishment systems are available.

NASA Marshall Space Flight Center Controls Systems Design and Analysis Branch

NASA Technical Reports Server (NTRS)

Gilligan, Eric

2014-01-01

Marshall Space Flight Center maintains a critical national capability in the analysis of launch vehicle flight dynamics and flight certification of GN&C algorithms. MSFC analysts are domain experts in the areas of flexible-body dynamics and control-structure interaction, thrust vector control, sloshing propellant dynamics, and advanced statistical methods. Marshall's modeling and simulation expertise has supported manned spaceflight for over 50 years. Marshall's unparalleled capability in launch vehicle guidance, navigation, and control technology stems from its rich heritage in developing, integrating, and testing launch vehicle GN&C systems dating to the early Mercury-Redstone and Saturn vehicles. The Marshall team is continuously developing novel methods for design, including advanced techniques for large-scale optimization and analysis.

Man in space - The use of animal models

NASA Technical Reports Server (NTRS)

Ballard, Rodney W.; Souza, Kenneth A.

1991-01-01

The use of animal surrogates as experimental subjects in order to provide essential missing information on the effects of long-term spaceflights, to validate countermeasures, and to test medical treatment techniques is discussed. Research needs also include the definition of biomedical adaptations to flight, and the developments of standards for safe space missions to assure human health and productivity during and following flight. NASA research plans in this area are outlined. Over the next 40 years, NASA plans to concentrate on the use of rodents and nonhuman primates as the models of choice for various physiological responses observed in humans during extended stays in space. This research will include flights on the Space Shuttle, unmanned biosatellites, and the Space Station Freedom.

Aeromonas proteolyrica bacteria in aerospace environments. [possible genetic alterations and effects on man

NASA Technical Reports Server (NTRS)

Foster, B. G.

1974-01-01

Preflight studies on Aeromonas proteolytica are reported to investigate the possibility of genetic alterations resulting in increased proteolysis in spacecraft environments. This organism may be present on human tissue and could pose medical problems if its endopeptidase and a hemolysin were to be produced in ususually high quantities or altered in such a way as to be more effective in their activities. Considered are: (1) Development of a nutrative holding medium for suspension of organisms; (2) the establishment of baseline information for the standardization of the assay for endopeptidase levels and hemolytic titers; (3) formulation of a method by which intracutaneous hemorrhage could be quantitated in guinea pig tissue; and (4) the responses of these organisms to parameters of spaceflight and experimentation.

The Influence of Passive Acceleration and Exercise+Acceleration on Work Capacity and Orthostasis

NASA Technical Reports Server (NTRS)

Simonson, S. R.; Cowell, S. A.; Stocks, J. M.; Biagini, H. W.; Vener, J. M.; Evetts, S. N.; Bailey, K. N.; Evans, J.; Knapp, C.; Greenleaf, J. E.

1999-01-01

The losses of aerobic power and orthostatic tolerance are significant effects of manned C) spaceflight that can negatively impact crew health and safety. Daily acceleration and aerobic training may ameliorate these effects. To determine the influence of passive intermittent +Gz acceleration (PA) training and active acceleration + interval exercise (AE) training on work 0 0 capacity and the acute (1 min) response to 70 deg head-up tilt, 6 men (X-Bar SD: age, 33 +/- 6 y; height, 178.3 +/- 4.6 cm; mass, 86.3 +/- 6.6 kg) participated in two 3-wk training protocols. It was hypothesized that PA and AE training would improve orthostatic tolerance and that the addition of aerobic conditioning, would not alter this effect.

KSC-04pd1398

NASA Image and Video Library

2004-06-30

KENNEDY SPACE CENTER, FLA. - Kimberly Beck is a Controlled Biological Systems trainee in the Spaceflight and Life Sciences Training Program. She is helping with growth studies supporting the WONDER (Water Offset Nutrient Delivery Experiment) flight payload, which is investigating hydroponic plant crop production in microgravity.

KSC-04PD-1398

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. Kimberly Beck is a Controlled Biological Systems trainee in the Spaceflight and Life Sciences Training Program. She is helping with growth studies supporting the WONDER (Water Offset Nutrient Delivery Experiment) flight payload, which is investigating hydroponic plant crop production in microgravity.

Enhanced Damage-Resistant Optics for Spaceflight Laser Systems: Workshop findings and recommendations

NASA Technical Reports Server (NTRS)

Schulze, Norman; Cimolino, Marc; Guenther, Arthur; Mcminn, Ted; Rainer, Frank; Schmid, Ansgar; Seitel, Steven C.; Soileau, M. J.; Theon, John S.; Walz, William

1991-01-01

NASA has defined a program to address critical laser-induced damage issues peculiar to its remote sensing systems. The Langley Research Center (LaRC), with input from the Goddard Space Flight Center (GSFC), has developed a program plan focusing on the certification of optical materials for spaceflight applications and the development of techniques to determine the reliability of such materials under extended laser exposures. This plan involves cooperative efforts between NASA and optics manufacturers to quantify the performance of optical materials for NASA systems and to ensure NASA's continued application of the highest quality optics possible for enhanced system reliability. A review panel was organized to assess NASA's optical damage concerns and to evaluate the effectiveness of the LaRC proposed program plan. This panel consisted of experts in the areas of laser-induced damage, optical coating manufacture, and the design and development of laser systems for space. The panel was presented information on NASA's current and planned laser remote sensing programs, laser-induced damage problems already encountered in NASA systems, and the proposed program plan to address these issues. Additionally, technical presentations were made on the state of the art in damage mechanisms, optical materials testing, and issues of coating manufacture germane to laser damage.

Physiological Health Challenges for Human Missions to Mars

NASA Technical Reports Server (NTRS)

Norsk, Peter

2015-01-01

During the next decades, manned space missions are expected to be aiming at the Lagrange points, near Earth asteroids, and Mars flyby and/or landing. The question is therefore: Are we ready to go? To answer this with a yes, we are currently using the International Space Station to develop an integrated human physiological countermeasure suite. The integrated countermeasure suite will most likely encounter: 1) Exercise devices for aerobic, dynamic and resistive exercise training; 2) sensory-motor computer training programs and anti-motion sickness medication for preparing EVAs and G-transitions; 3) lower limb bracelets for preventing and/or treating the VIIP (vision impairment and intracranial pressure) syndrome; 4) nutritional components for maintenance of bone, muscle, the cardiovascular system and preventing oxidative stress and damage and immune deficiencies (e. g. omega-3 fatty acids, PRO/K, anti-oxidants and less salt and iron); 5) bisphosphonates for preventing bone degradation.; 6) lower body compression garment and oral salt and fluid loading for landing on a planetary surface to combat orthostatic intolerance; 7) laboratory analysis equipment for individualized monitoring of biomarkers in blood, urine and saliva for estimation of health status in; 8) advanced ultrasound techniques for monitoring bone and cardiovascular health; and 9) computer modeling programs for individual health status assessments of efficiency and subsequent adjustments of countermeasures. In particular for future missions into deep space, we are concerned with the synergistic effects of weightlessness, radiation, operational constraints and other spaceflight environmental factors. Therefore, increased collaboration between physiological, behavioral, radiation and space vehicle design disciplines are strongly warranted. Another venue we are exploring in NASA's Human Research Program is the usefulness of artificial gravity for mitigating the health risks of long duration weightlessness.

Data Acquisition, Management, and Analysis in Support of the Audiology and Hearing Conservation and the Orbital Debris Program Office

NASA Technical Reports Server (NTRS)

Dicken, Todd

2012-01-01

My internship at Johnson Space Center, Houston TX comprised of working simultaneously in the Space Life Science Directorate (Clinical Services Branch, SD3) in Audiology and Hearing Conservation and in the Astromaterials Research and Exploration Sciences Directorate in the Orbital Debris Program Office (KX). The purpose of the project done to support the Audiology and Hearing Conservation Clinic (AuHCon) is to organize and analyze auditory test data that has been obtained from tests conducted onboard the International Space Station (ISS) and in Johnson Space Center's clinic. Astronauts undergo a special type of auditory test called an On-Orbit Hearing Assessment (OOHA), which monitors hearing function while crewmembers are exposed to noise and microgravity during long-duration spaceflight. Data needed to be formatted to assist the Audiologist in studying, analyzing and reporting OOHA results from all ISS missions, with comparison to conventional preflight and post-flight audiometric test results of crewmembers. Orbital debris is the #1 threat to manned spacecraft; therefore NASA is investing in different measurement techniques to acquire information on orbital debris. These measurements are taken with telescopes in different parts of the world to acquire brightness variations over time, from which size, rotation rates and material information can be determined for orbital debris. Currently many assumptions are taken to resolve size and material from observed brightness, therefore a laboratory (Optical Measurement Center) is used to simulate the space environment and acquire information of known targets suited to best model the orbital debris population. In the Orbital Debris Program Office (ODPO) telescopic data were acquired and analyzed to better assess the orbital debris population.

Spacecraft Power Systems Engineering: Solutions for NASA's Manned Space Program

NASA Technical Reports Server (NTRS)

Scott, John H.

2007-01-01

An overview of spacecraft power systems is presented, with a focus on applications in the manned space program. The topics include: 1) History; 2) State-of-the-art; 3) Development directions; 4) Focus on applications in the manned space program led from JSC; 5) Power Systems Engineering Trade Space; 6) Power Generation and Energy Storage; 7) Power Distribution and Control; and 8) Actuation

Readiness for First Crewed Flight

NASA Technical Reports Server (NTRS)

Schaible, Dawn M.

2011-01-01

The NASA Engineering and Safety Center (NESC) was requested to develop a generic framework for evaluating whether any given program has sufficiently complete and balanced plans in place to allow crewmembers to fly safely on a human spaceflight system for the first time (i.e., first crewed flight). The NESC assembled a small team which included experts with experience developing robotic and human spaceflight and aviation systems through first crewed test flight and into operational capability. The NESC team conducted a historical review of the steps leading up to the first crewed flights of Mercury through the Space Shuttle. Benchmarking was also conducted with the United States (U.S.) Air Force and U.S. Navy. This report contains documentation of that review.

Vertebrate Development in Space: Gravity Is a Drag (and Has Been for Eons and Eons)

NASA Technical Reports Server (NTRS)

Keefe, J. R.

1985-01-01

Brief sketches of developmental biology studies during spaceflight presented are intended to be complete in scope and to provide the reader with an overview of the present status of such studies. Means of evaluating both the direct role of gravity on all processes of mammalian reproduction and development as well as defining the means of assessing indirect transplacemental aspects are considered. The potential present in the development of a spaceflight system/program specifically designed to provide chronic exposure of a representative variety of mammalian species with periodic sampling for multiple generations to fully assess the potential impact of an altered gravitational vector on general mammalian development is also considered.

Dysrhythmias in Laypersons During Centrifuge-Simulated Suborbital Spaceflight.

PubMed

Suresh, Rahul; Blue, Rebecca S; Mathers, Charles H; Castleberry, Tarah L; Vanderploeg, James M

2017-11-01

There are limited data on cardiac dysrhythmias in laypersons during hypergravity exposure. We report layperson electrocardiograph (ECG) findings and tolerance of dysrhythmias during centrifuge-simulated suborbital spaceflight. Volunteers participated in varied-length centrifuge training programs of 2-7 centrifuge runs over 0.5-2 d, culminating in two simulated suborbital spaceflights of combined +Gz and +Gx (peak +4.0 Gz, +6.0 Gx, duration 5 s). Monitors recorded pre- and post-run mean arterial blood pressure (MAP), 6-s average heart rate (HR) collected at prespecified points during exposures, documented dysrhythmias observed on continuous 3-lead ECG, self-reported symptoms, and objective signs of intolerance on real-time video monitoring. Participating in the study were 148 subjects (43 women). Documented dysrhythmias included sinus pause (N = 5), couplet premature ventricular contractions (N = 4), bigeminy (N = 3), accelerated idioventricular rhythm (N = 1), and relative bradycardia (RB, defined as a transient HR drop of >20 bpm; N = 63). None were associated with subjective symptoms or objective signs of acceleration intolerance. Episodes of RB occurred only during +Gx exposures. Subjects had a higher post-run vs. pre-run MAP after all exposures, but demonstrated no difference in pre- and post-run HR. RB was more common in men, younger individuals, and subjects experiencing more centrifuge runs. Dysrhythmias in laypersons undergoing simulated suborbital spaceflight were well tolerated, though RB was frequently noted during short-duration +Gx exposure. No subjects demonstrated associated symptoms or objective hemodynamic sequelae from these events. Even so, heightened caution remains warranted when monitoring dysrhythmias in laypersons with significant cardiopulmonary disease or taking medications that modulate cardiac conduction.Suresh R, Blue RS, Mathers CH, Castleberry TL, Vanderploeg JM. Dysrhythmias in laypersons during centrifuge-stimulated suborbital spaceflight. Aerosp Med Hum Perform. 2017; 88(11):1008-1015.

Molecular aspects of stress-gene regulation during spaceflight

NASA Technical Reports Server (NTRS)

Paul, Anna-Lisa; Ferl, Robert J.

2002-01-01

Spaceflight-associated stress has been the topic of investigation since the first terrestrial organisms were exposed to this unique environment. Organisms that evolved under the selection pressures of earth-normal environments can perceive spaceflight as a stress, either directly because gravity influences an intrinsic biological process, or indirectly because of secondary effects imparted by spaceflight upon environmental conditions. Different organisms and even different organs within an organism adapt to a spaceflight environment with a diversity of tactics. Plants are keenly sensitive to gravity for directed development, and are also sensitive to other stresses associated with closed-system spaceflight environments. Within the past decade, the tools of molecular biology have begun to provide a sophisticated evaluation of spaceflight-associated stress and the genetic responses that accompany metabolic adaptation to spaceflight.

Human Exploration Science Office (KX) Overview

NASA Technical Reports Server (NTRS)

Calhoun, Tracy A.

2014-01-01

The Human Exploration Science Office supports human spaceflight, conducts research, and develops technology in the areas of space orbital debris, hypervelocity impact technology, image science and analysis, remote sensing, imagery integration, and human and robotic exploration science. NASA's Orbital Debris Program Office (ODPO) resides in the Human Exploration Science Office. ODPO provides leadership in orbital debris research and the development of national and international space policy on orbital debris. The office is recognized internationally for its measurement and modeling of the debris environment. It takes the lead in developing technical consensus across U.S. agencies and other space agencies on debris mitigation measures to protect users of the orbital environment. The Hypervelocity Impact Technology (HVIT) project evaluates the risks to spacecraft posed by micrometeoroid and orbital debris (MMOD). HVIT facilities at JSC and White Sands Test Facility (WSTF) use light gas guns, diagnostic tools, and high-speed imagery to quantify the response of spacecraft materials to MMOD impacts. Impact tests, with debris environment data provided by ODPO, are used by HVIT to predict risks to NASA and commercial spacecraft. HVIT directly serves NASA crew safety with MMOD risk assessments for each crewed mission and research into advanced shielding design for future missions. The Image Science and Analysis Group (ISAG) supports the International Space Station (ISS) and commercial spaceflight through the design of imagery acquisition schemes (ground- and vehicle-based) and imagery analyses for vehicle performance assessments and mission anomaly resolution. ISAG assists the Multi-Purpose Crew Vehicle (MPCV) Program in the development of camera systems for the Orion spacecraft that will serve as data sources for flight test objectives that lead to crewed missions. The multi-center Imagery Integration Team is led by the Human Exploration Science Office and provides expertise in the application of engineering imagery to spaceflight. The team links NASA programs and private industry with imagery capabilities developed and honed through decades of human spaceflight, including imagery integration, imaging assets, imagery data management, and photogrammetric analysis. The team is currently supporting several NASA programs, including commercial demonstration missions. The Earth Science and Remote Sensing Team is responsible for integrating the scientific use of Earth-observation assets onboard the ISS, which consist of externally mounted sensors and crew photography capabilities. This team facilitates collaboration on remote sensing and participates in research with academic organizations and other Government agencies, not only in conjunction with ISS science, but also for planetary exploration and regional environmental/geological studies. Human exploration science focuses on science strategies for future human exploration missions to the Moon, Mars, asteroids, and beyond. This function provides communication and coordination between the science community and mission planners. ARES scientists support the operation of robotic missions (i.e., Mars Exploration Rovers and the Mars Science Laboratory), contribute to the interpretation of returned mission data, and translate robotic mission technologies and techniques to human spaceflight.

Genetic dissection of the Arabidopsis spaceflight transcriptome: Are some responses dispensable for the physiological adaptation of plants to spaceflight?

PubMed Central

Sng, Natasha J.; Zupanska, Agata K.; Krishnamurthy, Aparna; Schultz, Eric R.; Ferl, Robert J.

2017-01-01

Experimentation on the International Space Station has reached the stage where repeated and nuanced transcriptome studies are beginning to illuminate the structural and metabolic differences between plants grown in space compared to plants on the Earth. Genes that are important in establishing the spaceflight responses are being identified, their roles in spaceflight physiological adaptation are increasingly understood, and the fact that different genotypes adapt differently is recognized. However, the basic question of whether these spaceflight responses are actually required for survival has yet to be posed, and the fundamental notion that spaceflight responses may be non-adaptive has yet to be explored. Therefore the experiments presented here were designed to ask if portions of the plant spaceflight response can be genetically removed without causing loss of spaceflight survival and without causing increased stress responses. The CARA experiment compared the spaceflight transcriptome responses in the root tips of two Arabidopsis ecotypes, Col-0 and WS, as well as that of a PhyD mutant of Col-0. When grown with the ambient light of the ISS, phyD plants displayed a significantly reduced spaceflight transcriptome response compared to Col-0, suggesting that altering the activity of a single gene can actually improve spaceflight adaptation by reducing the transcriptome cost of physiological adaptation. The WS genotype showed an even simpler spaceflight transcriptome response in the ambient light of the ISS, more broadly indicating that the plant genotype can be manipulated to reduce the cost of spaceflight adaptation, as measured by transcriptional response. These differential genotypic responses suggest that genetic manipulation could further reduce, or perhaps eliminate the metabolic cost of spaceflight adaptation. When plants were germinated and then left in the dark on the ISS, the WS genotype actually mounted a larger transcriptome response than Col-0, suggesting that the in-space light environment affects physiological adaptation, which implies that manipulating the local habitat can also substantially impact the metabolic cost of spaceflight adaptation. PMID:28662188

Genetic dissection of the Arabidopsis spaceflight transcriptome: Are some responses dispensable for the physiological adaptation of plants to spaceflight?

PubMed

Paul, Anna-Lisa; Sng, Natasha J; Zupanska, Agata K; Krishnamurthy, Aparna; Schultz, Eric R; Ferl, Robert J

2017-01-01

Experimentation on the International Space Station has reached the stage where repeated and nuanced transcriptome studies are beginning to illuminate the structural and metabolic differences between plants grown in space compared to plants on the Earth. Genes that are important in establishing the spaceflight responses are being identified, their roles in spaceflight physiological adaptation are increasingly understood, and the fact that different genotypes adapt differently is recognized. However, the basic question of whether these spaceflight responses are actually required for survival has yet to be posed, and the fundamental notion that spaceflight responses may be non-adaptive has yet to be explored. Therefore the experiments presented here were designed to ask if portions of the plant spaceflight response can be genetically removed without causing loss of spaceflight survival and without causing increased stress responses. The CARA experiment compared the spaceflight transcriptome responses in the root tips of two Arabidopsis ecotypes, Col-0 and WS, as well as that of a PhyD mutant of Col-0. When grown with the ambient light of the ISS, phyD plants displayed a significantly reduced spaceflight transcriptome response compared to Col-0, suggesting that altering the activity of a single gene can actually improve spaceflight adaptation by reducing the transcriptome cost of physiological adaptation. The WS genotype showed an even simpler spaceflight transcriptome response in the ambient light of the ISS, more broadly indicating that the plant genotype can be manipulated to reduce the cost of spaceflight adaptation, as measured by transcriptional response. These differential genotypic responses suggest that genetic manipulation could further reduce, or perhaps eliminate the metabolic cost of spaceflight adaptation. When plants were germinated and then left in the dark on the ISS, the WS genotype actually mounted a larger transcriptome response than Col-0, suggesting that the in-space light environment affects physiological adaptation, which implies that manipulating the local habitat can also substantially impact the metabolic cost of spaceflight adaptation.

Bone marrow mononuclears from murine tibia after spaceflight on biosatellite

NASA Astrophysics Data System (ADS)

Andreeva, Elena; Roe, Maria; Buravkova, Ludmila; Andrianova, Irina; Goncharova, Elena; Gornostaeva, Alexandra

Elucidation of the space flight effects on the adult stem and progenitor cells is an important goal in space biology and medicine. A unique opportunity for this is provided by project "BION -M1". The purpose of this study was to evaluate the effects of a 30-day flight on biosatellite "BION - M1" and the subsequent 7-day recovery on the quantity, viability, immunophenotype of mononuclears from murine tibia bone marrow. Also the in vitro characterization of functional capacity of multipotent mesenchymal stromal cells (MSCs) was scheduled. Under the project, the S57black/6 mice were divided into groups: spaceflight/vivarium control, recovery after spaceflight/ vivarium control to recovery. Bone marrow mononuclears were isolated from the tibia and immunophenotyped using antibodies against CD45, CD34, CD90 on a flow cytometer Epics XL (Beckman Coulter). A part of the each pool was frozen for subsequent estimation of hematopoietic colony-forming units (CFU), the rest was used for the evaluation of fibroblast CFU (CFUf) number, MSC proliferative activity and osteogenic potency. The cell number in the flight group was significantly lower than in the vivarium control group. There were no differences in this parameter between flight and control groups after 7 days of recovery. The mononuclears viability was more than 95 percent in all examined groups. Flow cytometric analysis showed no differences in the bone marrow cell immunophenotype (CD45, CD34, CD90.1 (Thy1)), but the flight animals had more large-sized CD45+mononuclears, than the control groups of mice. There was no difference in the CFUf number between groups. After 7 days in vitro the MSC number in flight group was twice higher than in vivarium group, after 10 days - 4 times higher. These data may indicate a higher proliferative activity of MSCs after spaceflight. MSCs showed the same and high alkaline phosphatase activity, both in flight and in the control groups, suggesting no effect of spaceflight factors on early osteogenic potency of stromal cells. These results indicate that spaceflight factors had no significant damaging effects on the murine bone marrow mononuclears. These observations are consistent with previously made assumption of moderate and reversible stress reaction of mammals on spaceflight conditions. This work was supported by Program of Basic Research of IMBP RAS

GeneLab: Open Science For Exploration

NASA Technical Reports Server (NTRS)

Galazka, Jonathan

2018-01-01

The NASA GeneLab project capitalizes on multi-omic technologies to maximize the return on spaceflight experiments. The GeneLab project houses spaceflight and spaceflight-relevant multi-omics data in a publicly accessible data commons, and collaborates with NASA-funded principal investigators to maximize the omics data from spaceflight and spaceflight-relevant experiments. I will discuss the current status of GeneLab and give specific examples of how the GeneLab data system has been used to gain insight into how biology responds to spaceflight conditions.

New challenges for Life Sciences flight project management

NASA Technical Reports Server (NTRS)

Huntoon, C. L.

1999-01-01

Scientists have conducted studies involving human spaceflight crews for over three decades. These studies have progressed from simple observations before and after each flight to sophisticated experiments during flights of several weeks up to several months. The findings from these experiments are available in the scientific literature. Management of these flight experiments has grown into a system fashioned from the Apollo Program style, focusing on budgeting, scheduling and allocation of human and material resources. While these areas remain important to the future, the International Space Station (ISS) requires that the Life Sciences spaceflight experiments expand the existing project management methodology. The use of telescience with state-the-art information technology and the multi-national crews and investigators challenges the former management processes. Actually conducting experiments on board the ISS will be an enormous undertaking and International Agreements and Working Groups will be essential in giving guidance to the flight project management Teams forged in this matrix environment must be competent to make decisions and qualified to work with the array of engineers, scientists, and the spaceflight crews. In order to undertake this complex task, data systems not previously used for these purposes must be adapted so that the investigators and the project management personnel can all share in important information as soon as it is available. The utilization of telescience and distributed experiment operations will allow the investigator to remain involved in their experiment as well as to understand the numerous issues faced by other elements of the program The complexity in formation and management of project teams will be a new kind of challenge for international science programs. Meeting that challenge is essential to assure success of the International Space Station as a laboratory in space.

New challenges for Life Sciences flight project management.

PubMed

Huntoon, C L

1999-01-01

Scientists have conducted studies involving human spaceflight crews for over three decades. These studies have progressed from simple observations before and after each flight to sophisticated experiments during flights of several weeks up to several months. The findings from these experiments are available in the scientific literature. Management of these flight experiments has grown into a system fashioned from the Apollo Program style, focusing on budgeting, scheduling and allocation of human and material resources. While these areas remain important to the future, the International Space Station (ISS) requires that the Life Sciences spaceflight experiments expand the existing project management methodology. The use of telescience with state-the-art information technology and the multi-national crews and investigators challenges the former management processes. Actually conducting experiments on board the ISS will be an enormous undertaking and International Agreements and Working Groups will be essential in giving guidance to the flight project management Teams forged in this matrix environment must be competent to make decisions and qualified to work with the array of engineers, scientists, and the spaceflight crews. In order to undertake this complex task, data systems not previously used for these purposes must be adapted so that the investigators and the project management personnel can all share in important information as soon as it is available. The utilization of telescience and distributed experiment operations will allow the investigator to remain involved in their experiment as well as to understand the numerous issues faced by other elements of the program The complexity in formation and management of project teams will be a new kind of challenge for international science programs. Meeting that challenge is essential to assure success of the International Space Station as a laboratory in space.

New challenges for life sciences flight project management

NASA Astrophysics Data System (ADS)

Huntoon, Carolyn L.

1999-09-01

Scientists have conducted studies involving human spaceflight crews for over three decades. These studies have progressed from simple observations before and after each flight to sophisticated experiments during flights of several weeks up to several months. The findings from these experiments are available in the scientific literature. Management of these flight experiments has grown into a system fashioned from the Apollo Program style, focusing on budgeting, scheduling and allocation of human and material resources. While these areas remain important to the future, the International Space Station (ISS) requires that the Life Sciences spaceflight experiments expand the existing project management methodology. The use of telescience with state-of-the-art information technology and the multi-national crews and investigators challenges the former management processes. Actually conducting experiments on board the ISS will be an enormous undertaking and International Agreements and Working Groups will be essential in giving guidance to the flight project management Teams forged in this matrix environment must be competent to make decisions and qualified to work with the array of engineers, scientists, and the spaceflight crews. In order to undertake this complex task, data systems not previously used for these purposes must be adapted so that the investigators and the project management personnel can all share in important information as soon as it is available. The utilization of telescience and distributed experiment operations will allow the investigator to remain involved in their experiment as well as to understand the numerous issues faced by other elements of the program. The complexity in formation and management of project teams will be a new kind of challenge for international science programs. Meeting that challenge is essential to assure success of the International Space Station as a laboratory in space.

GeneLab: Multi-Omics Investigation of Rodent Research-1 Bio-Banked Tissues

NASA Technical Reports Server (NTRS)

Lai, San-Huei; Boyko, Valery; Chakravarty, Kaushik; Chen, Rick; Dueck, Sandra; Berrios, Daniel C.; Fogle, Homer; Marcu, Oana; Timucin, Linda; Reinsch, Sigrid;

Immune Modulation in Normal Human Peripheral Blood Mononuclear Cells (PBMCs) (Lymphocytes) in Response to Benzofuran-2-Carboxylic Acid Derivative KMEG during Spaceflight

NASA Astrophysics Data System (ADS)

Okoro, Elvis; Mann, Vivek; Ellis, Ivory; Mansoor, Elvedina; Olamigoke, Loretta; Marriott, Karla Sue; Denkins, Pamela; Williams, Willie; Sundaresan, Alamelu

2017-08-01

Microgravity and radiation exposure during space flight have been widely reported to induce the suppression of normal immune system function, and increase the risk of cancer development in humans. These findings pose a serious risk to manned space missions. Interestingly, recent studies have shown that benzofuran-2-carboxylic acid derivatives can inhibit the progression of some of these devastating effects on earth and in modeled microgravity. However, these studies had not assessed the impacts of benzofuran-2- carboxylic acid and its derivatives on global gene expression under spaceflight conditions. In this study, the ability of a specific benzofuran-2-carboxylic acid derivative (KMEG) to confer protection from radiation and restore normal immune function was investigated following exposure to space flight conditions on the ISS. Normal human peripheral blood mononuclear cells (lymphocytes) treated with 10 µ g/ml of KMEG together with untreated control samples were flown on Nanoracks hardware on Spacex-3 flight. The Samples were returned one month later and gene expression was analyzed. A 1g-ground control experiment was performed in parallel at the Kennedy spaceflight center. The first overall subtractive unrestricted analysis revealed 78 genes, which were differentially expressed in space flight KMEG, untreated lymphocytes as compared to the corresponding ground controls. However, in KMEG-treated space flight lymphocytes, there was an increased expression of a group of genes that mediate increased transcription, translation and innate immune system mediating functions of lymphocytes as compared to KMEG-untreated samples. Analysis of genes related to T cell proliferation in spaceflight KMEG-treated lymphocytes compared to 1g-ground KMEG- treated lymphocytes revealed six T cell proliferation and signaling genes to be significantly upregulated (p < 0.001) and five related genes were found to be significantly down-regulated. These genes play a significant role in promoting the proliferation of T-lymphocytes, the regulation of membrane trafficking, promote early response, mediating C-myc related proliferation, promote antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. Overall, our analysis indicates that KMEG promotes T- cell proliferation and has an anti-inflammatory effect, thereby increasing immunity and possible protection from chronic inflammation setting which is optimally required during long term space flights.

Cardiovascular, renal, electrolyte, and hormonal changes in man during gravitational stress, weightlessness, and simulated weightlessness: Lower body positive pressure applied by the antigravity suit. Thesis - Oslo Univ.

NASA Technical Reports Server (NTRS)

Kravik, Stein E.

1989-01-01

Because of their erect posture, humans are more vulnerable to gravitational changes than any other animal. During standing or walking man must constantly use his antigravity muscles and his two columns, his legs, to balance against the force of gravity. At the same time, blood is surging downward to the dependent portions of the body, draining blood away from the brain and heart, and requiring a series of complex cardiovascular adjustments to maintain the human in a bipedal position. It was not until 12 April 1961, when Yuri Gagarin became the first human being to orbit Earth, that we could confirm man's ability to maintain vital functions in space -- at least for 90 min. Nevertheless, man's adaptation to weightlessness entails the deconditioning of various organs in the body. Muscles atrophy, and calcium loss leads to loss of bone strength as the demands on the musculoskeletal system are almost nonexistent in weightlessness. Because of the lack of hydrostatic pressures in space, blood rushes to the upper portions of the body, initiating a complex series of cardioregulatory responses. Deconditioning during spaceflight, however, first becomes a potentially serious problem in humans returning to Earth, when the cardiovascular system, muscles and bones are suddenly exposed to the demanding counterforce of gravity -- weight. One of the main purposes of our studies was to test the feasibility of using Lower Body Positive Pressure, applied with an antigravity suit, as a new and alternative technique to bed rest and water immersion for studying cardioregulatory, renal, electrolyte, and hormonal changes in humans. The results suggest that Lower Body Positive Pressure can be used as an analog of microgravity-induced physiological responses in humans.

The Integrated Medical Model

NASA Technical Reports Server (NTRS)

Butler, Douglas J.; Kerstman, Eric

2010-01-01

This slide presentation reviews the goals and approach for the Integrated Medical Model (IMM). The IMM is a software decision support tool that forecasts medical events during spaceflight and optimizes medical systems during simulations. It includes information on the software capabilities, program stakeholders, use history, and the software logic.

KSC-03PD-2144

NASA Technical Reports Server (NTRS)

2003-01-01

KENNEDY SPACE CENTER, FLA. (From left) Brian Duffy, Lockheed Martin vice president/associate program manager, Mildred Carter and Col. (Ret.) Herbert E. Carter, one of the Tuskegee Airmen, attend a dinner sponsored by the KSC Spaceflight and Life Sciences Office. Col. Carter was a guest speaker at the dinner.

Eric Boe and Bob Behnken Dragon Tour

NASA Image and Video Library

2017-03-08

During a tour of SpaceX headquarters in Hawthorne, California, commercial crew astronaut Bob Behnken views the Crew Dragon on March 8, 2017. Crew Dragon is being developed and manufactured in partnership with NASA's Commercial Crew Program to return human spaceflight capabilities to the U.S.

International Co-ordinating Council of the Programme on Man and the Biosphere (MAB). Final Report.

ERIC Educational Resources Information Center

United Nations Educational, Scientific, and Cultural Organization, Paris (France).

Man and the Biosphere Program is an interdisciplinary program of research which emphasizes an ecological approach to the study of interrelationships between man and the environment. It is concerned with subjects of global or major regional significance which require international cooperation. This final report discusses areas in which…

NASA Astronaut Occupational Surveillance Program and Lifetime Surveillance of Astronaut Health, LSAH, Astronaut Exposures and Risk in the Terrestrial and Spaceflight Environment

NASA Technical Reports Server (NTRS)

Keprta, Sean R.; Tarver, William; Van Baalen, Mary; McCoy, Torin

2015-01-01

United States Astronauts have a very unique occupational exposure profile. In order to understand these risks and properly address them, the National Aeronautics and Atmospheric Administration, NASA, originally created the Longitudinal Study of Astronaut Health, LSAH. The first LSAH was designed to address a variety of needs regarding astronaut health and included a 3 to 1 terrestrial control population in order to compare United States "earth normal" disease and aging to that of a microgravity exposed astronaut. Over the years that program has been modified, now termed Lifetime Surveillance of Astronaut Health, still LSAH. Astronaut spaceflight exposures have also changed, with the move from short duration shuttle flights to long duration stays on international space station and considerable terrestrial training activities. This new LSAH incorporates more of an occupational health and medicine model to the study of occupationally exposed astronauts. The presentation outlines the baseline exposures and monitoring of the astronaut population to exposures, both terrestrial, and in space.

History of space medicine: the formative years at NASA.

PubMed

Berry, Charles A; Hoffler, G Wyckliffe; Jernigan, Clarence A; Kerwin, Joseph P; Mohler, Stanley R

2009-04-01

Almost nothing was known about the effects of spaceflight on human physiology when, in May of 1961, President John F. Kennedy committed the United States to land a man on the Moon and return him safely to Earth within the decade. There were more questions than answers regarding the effects of acceleration, vibration, cabin pressure, CO2 concentration, and microgravity. There were known external threats to life, such as solar and ultraviolet radiation, meteorites, and extreme temperatures as well as issues for which the physicians and scientists could not even formulate the questions. And there was no time for controlled experiments with the required numbers of animal or human subjects. Of necessity, risks were evaluated and mitigated or accepted based on minimal data. This article summarizes presentations originally given as a panel at the 79th Annual Scientific Meeting of the Aerospace Medical Association in Boston in 2008. In it, five pioneers in space medicine at NASA looked back on the development of their field. The authors related personal anecdotes, discussed the roles of various people and presented examples of contributions to emerging U.S. initiatives for human spaceflight. Topics included the development of quarantine facilities for returning Apollo astronauts, the struggles between operational medicine and research personnel, and observations from the first U.S. medical officer to experience weightlessness on orbit. Brief biographies of the authors are appended to document their participation in these historic events.

Effect of spaceflight on the circadian rhythm, lifespan and gene expression of Drosophila melanogaster.

PubMed

Ma, Lingling; Ma, Jun; Xu, Kanyan

2015-01-01

Space travelers are reported to experience circadian rhythm disruption during spaceflight. However, how the space environment affects circadian rhythm is yet to be determined. The major focus of this study was to investigate the effect of spaceflight on the Drosophila circadian clock at both the behavioral and molecular level. We used China's Shenzhou-9 spaceship to carry Drosophila. After 13 days of spaceflight, behavior tests showed that the flies maintained normal locomotor activity rhythm and sleep pattern. The expression level and rhythm of major clock genes were also unaffected. However, expression profiling showed differentially regulated output genes of the circadian clock system between space flown and control flies, suggesting that spaceflight affected the circadian output pathway. We also investigated other physiological effects of spaceflight such as lipid metabolism and lifespan, and searched genes significantly affected by spaceflight using microarray analysis. These results provide new information on the effects of spaceflight on circadian rhythm, lipid metabolism and lifespan. Furthermore, we showed that studying the effect of spaceflight on gene expression using samples collected at different Zeitgeber time could obtain different results, suggesting the importance of appropriate sampling procedures in studies on the effects of spaceflight.

Effect of Spaceflight on the Circadian Rhythm, Lifespan and Gene Expression of Drosophila melanogaster

PubMed Central

Xu, Kanyan

2015-01-01

Space travelers are reported to experience circadian rhythm disruption during spaceflight. However, how the space environment affects circadian rhythm is yet to be determined. The major focus of this study was to investigate the effect of spaceflight on the Drosophila circadian clock at both the behavioral and molecular level. We used China’s Shenzhou-9 spaceship to carry Drosophila. After 13 days of spaceflight, behavior tests showed that the flies maintained normal locomotor activity rhythm and sleep pattern. The expression level and rhythm of major clock genes were also unaffected. However, expression profiling showed differentially regulated output genes of the circadian clock system between space flown and control flies, suggesting that spaceflight affected the circadian output pathway. We also investigated other physiological effects of spaceflight such as lipid metabolism and lifespan, and searched genes significantly affected by spaceflight using microarray analysis. These results provide new information on the effects of spaceflight on circadian rhythm, lipid metabolism and lifespan. Furthermore, we showed that studying the effect of spaceflight on gene expression using samples collected at different Zeitgeber time could obtain different results, suggesting the importance of appropriate sampling procedures in studies on the effects of spaceflight. PMID:25798821

ARG1 Functions in the Physiological Adaptation of Undifferentiated Plant Cells to Spaceflight

NASA Astrophysics Data System (ADS)

Zupanska, Agata K.; Schultz, Eric R.; Yao, JiQiang; Sng, Natasha J.; Zhou, Mingqi; Callaham, Jordan B.; Ferl, Robert J.; Paul, Anna-Lisa

2017-11-01

Scientific access to spaceflight and especially the International Space Station has revealed that physiological adaptation to spaceflight is accompanied or enabled by changes in gene expression that significantly alter the transcriptome of cells in spaceflight. A wide range of experiments have shown that plant physiological adaptation to spaceflight involves gene expression changes that alter cell wall and other metabolisms. However, while transcriptome profiling aptly illuminates changes in gene expression that accompany spaceflight adaptation, mutation analysis is required to illuminate key elements required for that adaptation. Here we report how transcriptome profiling was used to gain insight into the spaceflight adaptation role of Altered response to gravity 1 (Arg1), a gene known to affect gravity responses in plants on Earth. The study compared expression profiles of cultured lines of Arabidopsis thaliana derived from wild-type (WT) cultivar Col-0 to profiles from a knock-out line deficient in the gene encoding ARG1 (ARG1 KO), both on the ground and in space. The cell lines were launched on SpaceX CRS-2 as part of the Cellular Expression Logic (CEL) experiment of the BRIC-17 spaceflight mission. The cultured cell lines were grown within 60 mm Petri plates in Petri Dish Fixation Units (PDFUs) that were housed within the Biological Research In Canisters (BRIC) hardware. Spaceflight samples were fixed on orbit. Differentially expressed genes were identified between the two environments (spaceflight and comparable ground controls) and the two genotypes (WT and ARG1 KO). Each genotype engaged unique genes during physiological adaptation to the spaceflight environment, with little overlap. Most of the genes altered in expression in spaceflight in WT cells were found to be Arg1-dependent, suggesting a major role for that gene in the physiological adaptation of undifferentiated cells to spaceflight.

Making Human Spaceflight Practical and Affordable: Spacecraft Designs and their Degree of Operability

NASA Technical Reports Server (NTRS)

Crocker, Alan R.

2011-01-01

As we push toward new and diverse space transportation capabilities, reduction in operations cost becomes increasingly important. Achieving affordable and safe human spaceflight capabilities will be the mark of success for new programs and new providers. The ability to perceive the operational implications of design decisions is crucial in developing safe yet cost competitive space transportation systems. Any human spaceflight program - government or commercial - must make countless decisions either to implement spacecraft system capabilities or adopt operational constraints or workarounds to account for the lack of such spacecraft capabilities. These decisions can benefit from the collective experience that NASA has accumulated in building and operating crewed spacecraft over the last five decades. This paper reviews NASA s history in developing and operating human rated spacecraft, reviewing the key aspects of spacecraft design and their resultant impacts on operations phase complexity and cost. Specific examples from current and past programs - including the Space Shuttle and International Space Station - are provided to illustrate design traits that either increase or increase cost and complexity associated with spacecraft operations. These examples address factors such as overall design performance margins, levels of redundancy, degree of automated failure response, type and quantity of command and telemetry interfaces, and the definition of reference scenarios for analysis and test. Each example - from early program requirements, design implementation and resulting real-time operations experience - to tell the end-to-end "story" Based on these experiences, specific techniques are recommended to enable earlier and more effective assessment of operations concerns during the design process. A formal method for the assessment of spacecraft operability is defined and results of such operability assessments for recent spacecraft designs are provided. Recent experience in applying these techniques to Orion spacecraft development is reviewed to highlight the direct benefits of early operational assessment and collaborative development efforts.

ARG1 Functions in the Physiological Adaptation of Undifferentiated Plant Cells to Spaceflight.

PubMed

Zupanska, Agata K; Schultz, Eric R; Yao, JiQiang; Sng, Natasha J; Zhou, Mingqi; Callaham, Jordan B; Ferl, Robert J; Paul, Anna-Lisa

2017-11-01

Scientific access to spaceflight and especially the International Space Station has revealed that physiological adaptation to spaceflight is accompanied or enabled by changes in gene expression that significantly alter the transcriptome of cells in spaceflight. A wide range of experiments have shown that plant physiological adaptation to spaceflight involves gene expression changes that alter cell wall and other metabolisms. However, while transcriptome profiling aptly illuminates changes in gene expression that accompany spaceflight adaptation, mutation analysis is required to illuminate key elements required for that adaptation. Here we report how transcriptome profiling was used to gain insight into the spaceflight adaptation role of Altered response to gravity 1 (Arg1), a gene known to affect gravity responses in plants on Earth. The study compared expression profiles of cultured lines of Arabidopsis thaliana derived from wild-type (WT) cultivar Col-0 to profiles from a knock-out line deficient in the gene encoding ARG1 (ARG1 KO), both on the ground and in space. The cell lines were launched on SpaceX CRS-2 as part of the Cellular Expression Logic (CEL) experiment of the BRIC-17 spaceflight mission. The cultured cell lines were grown within 60 mm Petri plates in Petri Dish Fixation Units (PDFUs) that were housed within the Biological Research In Canisters (BRIC) hardware. Spaceflight samples were fixed on orbit. Differentially expressed genes were identified between the two environments (spaceflight and comparable ground controls) and the two genotypes (WT and ARG1 KO). Each genotype engaged unique genes during physiological adaptation to the spaceflight environment, with little overlap. Most of the genes altered in expression in spaceflight in WT cells were found to be Arg1-dependent, suggesting a major role for that gene in the physiological adaptation of undifferentiated cells to spaceflight. Key Words: ARG1-Spaceflight-Gene expression-Physiological adaptation-BRIC. Astrobiology 17, 1077-1111.

Evolution of Flexible Multibody Dynamics for Simulation Applications Supporting Human Spaceflight

NASA Technical Reports Server (NTRS)

Huynh, An; Brain, Thomas A.; MacLean, John R.; Quiocho, Leslie J.

2016-01-01

During the course of transition from the Space Shuttle and International Space Station programs to the Orion and Journey to Mars exploration programs, a generic flexible multibody dynamics formulation and associated software implementation has evolved to meet an ever changing set of requirements at the NASA Johnson Space Center (JSC). Challenging problems related to large transitional topologies and robotic free-flyer vehicle capture/ release, contact dynamics, and exploration missions concept evaluation through simulation (e.g., asteroid surface operations) have driven this continued development. Coupled with this need is the requirement to oftentimes support human spaceflight operations in real-time. Moreover, it has been desirable to allow even more rapid prototyping of on-orbit manipulator and spacecraft systems, to support less complex infrastructure software for massively integrated simulations, to yield further computational efficiencies, and to take advantage of recent advances and availability of multi-core computing platforms. Since engineering analysis, procedures development, and crew familiarity/training for human spaceflight is fundamental to JSC's charter, there is also a strong desire to share and reuse models in both the non-realtime and real-time domains, with the goal of retaining as much multibody dynamics fidelity as possible. Three specific enhancements are reviewed here: (1) linked list organization to address large transitional topologies, (2) body level model order reduction, and (3) parallel formulation/implementation. This paper provides a detailed overview of these primary updates to JSC's flexible multibody dynamics algorithms as well as a comparison of numerical results to previous formulations and associated software.

Achieving the Proper Balance Between Crew and Public Safety

NASA Technical Reports Server (NTRS)

Gowan, John; Silvestri, Ray; Stahl, Ben; Rosati, Paul; Wilde, Paul

2011-01-01

A paramount objective of all human-rated launch and reentry vehicle developers is to ensure that the risks to both the crew onboard and the public are minimized within reasonable cost, schedule, and technical constraints. Past experience has shown that proper attention to range safety requirements necessary to ensure public safety must be given early in the design phase to avoid additional operational complexities or threats to the safety of people onboard, and the design engineers must give these requirements the same consideration as crew safety requirements. For human spaceflight, the primary purpose and operational concept for any flight safety system is to protect the public while maximizing the likelihood of crew survival. This paper will outline the policy considerations, technical issues, and operational impacts regarding launch and reentry vehicle failure scenarios where crew and public safety are intertwined and thus addressed optimally in an integrated manner. An overview of existing range and crew safety policy requirements will be presented. Application of these requirements and lessons learned from both the Space Shuttle and Constellation Programs will also be discussed. Using these past programs as examples, the paper will detail operational, design, and analysis approaches to mitigate and balance the risks to people onboard and in the public. Manned vehicle perspectives from the Federal Aviation Administration (FAA) and Air Force organizations that oversee public safety will be summarized as well. Finally, the paper will emphasize the need to factor policy, operational, and analysis considerations into the early design trades of new vehicles to help ensure that both crew and public safety are maximized to the greatest extent possible.

Things That Scientists Don't Understand About NASA Spaceflight Research

NASA Technical Reports Server (NTRS)

Platts, S. H.; Bauer, Terri; Rogers, Shanna

2017-01-01

So you want to conduct human spaceflight research aboard the International Space Station (ISS)? Once your spaceflight research aboard the ISS is proposal is funded.... the real work begins. Because resources are so limited for ISS research, it is necessary to maximize the work being done, while at the same time, minimizing the resources spent. Astronauts may be presented with over 30 human research experiments and select, on average approximately 15 in which to participate. In order to conduct this many studies, ISSMP uses the study requirements provided by the principle investigator to integrate all of this work into the astronauts' complement. The most important thing for investigators to convey to the ISSMP team is their RESEARCH REQUIREMENTS. Requirements are captured in the Experiment document. This document is the official record of how, what, where and when data will be collected. One common mistake that investigators make is not taking this document seriously, but when push comes to shove, if a research requirement is not in this document....it will not get done. The research requirements are then integrated to form a complement of research for each astronaut. What do we mean by integration? Many experiments have overlapping requirements; blood draws, behavioral surveys, heart rate measurement. Where possible, these measures are combined to reduce redundancy and save crew time. Investigators can access these data via data sharing agreements. More examples of how ISS research is integrated will be presented. There are additional limitations commonly associated with human spaceflight research that will also be discussed. Large/heavy hardware, invasive procedures, and toxic reagents are extremely difficult to implement on the ISS. There are strict limits placed on the amount of blood that can be drawn from crew members during (and immediately after) spaceflight. These limits are based on 30-day rolling accumulations. We have recently had to start restricting studies due to this limit. The NASA Human Research Program (HRP) provides extensive support, via ISSMP, to help investigators cope with all of the intricacies of conducting human spaceflight research. This presentation will help you take the best advantage of that support.

Human Skeletal Muscle Health with Spaceflight

NASA Astrophysics Data System (ADS)

Trappe, Scott

2012-07-01

This lecture will overview the most recent aerobic and resistance exercise programs used by crewmembers while aboard the International Space Station (ISS) for six months and examine its effectiveness for protecting skeletal muscle health. Detailed information on the exercise prescription program, whole muscle size, whole muscle performance, and cellular data obtained from muscle biopsy samples will be presented. Historically, detailed information on the exercise program while in space has not been available. These most recent exercise and muscle physiology findings provide a critical foundation to guide the exercise countermeasure program forward for future long-duration space missions.

Kennedy Space Center: Constellation Program Electrical Ground Support Equipment Research and Development

NASA Technical Reports Server (NTRS)

McCoy, Keegan

2010-01-01

The Kennedy Space Center (KSC) is NASA's spaceport, launching rockets into space and leading important human spaceflight research. This spring semester, I worked at KSC on Constellation Program electrical ground support equipment through NASA's Undergraduate Student Research Program (USRP). This report includes a discussion of NASA, KSC, and my individual research project. An analysis of Penn State's preparation of me for an internship and my overall impressions of the Penn State and NASA internship experience conclude the report.

The role of cytokines in immune changes induced by spaceflight

NASA Technical Reports Server (NTRS)

Sonnenfeld, G.; Miller, E. S.

1993-01-01

It has become apparent that spaceflight alters many immune responses. Among the regulatory components of the immune response that have been shown to be affected by spaceflight is the cytokine network. Spaceflight, as well as model systems of spaceflight, have been shown to affect the production and action of various cytokines including interferons, interleukins, colony stimulating factors, and tumor necrosis factors. These changes have been shown not to involve a general shutdown of the cytokine network but, rather, to involve selective alterations of specific cytokine functions by spaceflight. The full breadth of changes in cytokines induced by spaceflight, as well as mechanisms, duration, adaptation, reversibility, and significance to resistance to infection and neoplastic diseases, remains to be established.

The postmitotic Saccharomyces cerevisiae after spaceflight showed higher viability

NASA Astrophysics Data System (ADS)

Yi, Zong-Chun; Li, Xiao-Fei; Wang, Yan; Wang, Jie; Sun, Yan; Zhuang, Feng-Yuan

2011-06-01

The budding yeast Saccharomyces cerevisiae has been proposed as an ideal model organism for clarifying the biological effects caused by spaceflight conditions. The postmitotic S. cerevisiae cells onboard Practice eight recoverable satellite were subjected to spaceflight for 15 days. After recovery, the viability, the glycogen content, the activities of carbohydrate metabolism enzymes, the DNA content and the lipid peroxidation level in yeast cells were analyzed. The viability of the postmitotic yeast cells after spaceflight showed a three-fold increase as compared with that of the ground control cells. Compared to the ground control cells, the lipid peroxidation level in the spaceflight yeast cells markedly decreased. The spaceflight yeast cells also showed an increase in G2/M cell population and a decrease in Sub-G1 cell population. The glycogen content and the activities of hexokinase and succinate dehydrogenase significantly decreased in the yeast cells after spaceflight. In contrast, the activity of malate dehydrogenase showed an obvious increase after spaceflight. These results suggested that microgravity or spaceflight could promote the survival of postmitotic S. cerevisiae cells through regulating carbohydrate metabolism, ROS level and cell cycle progression.

The NASA Electronic Parts and Packaging (NEPP) Program: NEPP Overview - Automotive Electronics

NASA Technical Reports Server (NTRS)

LaBel, Kenneth A.; Sampson, Michael J.

2016-01-01

The results of NASAs studies into the appropriateness of using U.S. Automotive electronic parts in NASA spaceflight systems will be presented. The first part of the presentation provides an overview of the United States Automotive Electronics Council's AECQ standardization program, the second part provides a summary of the results of NASA's procurement and testing experiences and other lessons learned along with preliminary test results.

Effects of CSF hormones and ionic composition on salt/water metabolism

NASA Technical Reports Server (NTRS)

Severs, Walter B.; Keil, Lanny C.

1992-01-01

This collaborative agreement between Drs. Severs and Keil began in 1981, arising from a continuing interest in the issue of what, exactly, are the consequences of headward fluid shifts during manned spaceflight. Such shifts were recognized early by both U.S. and Soviet Scientists because of signs and symptoms referable to the head. Some of these include disturbed vision, puffiness in the face and periorbital areas, headache, vestibular dysfunction and distended jugular veins. We posited that the fluid shift had an immediate effect on the brain, and a long-term action requiring a neural interpretation of the flight environment. This would re-adjust both efferent neural as well as hormonal mechanisms to sustain cardiovascular and fluid/electrolyte balance consonent with survival in microgravity. Work along these lines is summarized.

Astronaut Alan Shepard is rescued by helicopter at end of MR-3 flight

NASA Image and Video Library

1961-05-05

S88-31376 (5 May 1961) --- Astronaut Alan B. Shepard Jr., pilot of the Mercury-Redstone 3 (MR-3) suborbital spaceflight, is retrieved by a helicopter from the USS Lake Champlain during recovery operations in the western Atlantic Ocean. Shepard and the Mercury spacecraft designated the ?Freedom 7? (floating in water below) were flown to the deck of the recovery ship within 11 minutes of splashdown. MR-3 was the United States? first manned space mission. The spacecraft attained a maximum speed of 5,180 miles per hour, reached an altitude of 116 1/2 statute miles, and landed 302 statute miles downrange from Cape Canaveral, Florida. The suborbital mission lasted 15 minutes and 22 seconds. Photo credit: NASA or National Aeronautics and Space Administration

Behavioral toxicity of selected radioprotectors

NASA Astrophysics Data System (ADS)

Landauer, M. R.; Davis, H. D.; Kumar, K. S.; Weiss, J. F.

1992-10-01

Effective radioprotection with minimal behavioral disruption is essential for the selection of protective agents to be used in manned spaceflight. This overview summarizes the studies on the behavioral toxicity of selected radioprotectors classified as phosphorothioates (WR-2721, WR-3689), bioactive lipids (16, 16 dimethylprostaglandin E2(DiPGE2), platelet activating factor (PAF), leukotriene C4), and immunomodulators (glucan, synthetic trehalose dicorynomycolate, and interleukin-1). Behavioral toxicity was examined in laboratory mice using a locomotor activity test. For all compounds tested, there was a dose-dependent decrease in locomotor behavior that paralleled the dose-dependent increase in radioprotection. While combinations of radioprotective compounds (DiPGE2 plus WR-2721) increased radioprotection, they also decreased locomotor activity. The central nervous system stimulant, caffeine, was able to mitigate the locomotor decrement produced by WR-3689 or PAF.

How the science and engineering of spaceflight contribute to understanding the plasticity of spinal cord injury

NASA Technical Reports Server (NTRS)

Edgerton, V. R.; Roy, R. R.; Hodgson, J. A.; Day, M. K.; Weiss, J.; Harkema, S. J.; Dobkin, B.; Garfinkel, A.; Konigsberg, E.; Koslovskaya, I.

2000-01-01

Space programs support experimental investigations related to the unique environment of space and to the technological developments from many disciplines of both science and engineering that contribute to space studies. Furthermore, interactions between scientists, engineers and administrators, that are necessary for the success of any science mission in space, promote interdiscipline communication, understanding and interests which extend well beyond a specific mission. NASA-catalyzed collaborations have benefited the spinal cord rehabilitation program at UCLA in fundamental science and in the application of expertise and technologies originally developed for the space program. Examples of these benefits include: (1) better understanding of the role of load in maintaining healthy muscle and motor function, resulting in a spinal cord injury (SCI) rehabilitation program based on muscle/limb loading; (2) investigation of a potentially novel growth factor affected by spaceflight which may help regulate muscle mass; (3) development of implantable sensors, electronics and software to monitor and analyze long-term muscle activity in unrestrained subjects; (4) development of hardware to assist therapies applied to SCI patients; and (5) development of computer models to simulate stepping which will be used to investigate the effects of neurological deficits (muscle weakness or inappropriate activation) and to evaluate therapies to correct these deficiencies.

Analysis and Design of a Human Spaceflight to Mars, Europa, and Titan

NASA Astrophysics Data System (ADS)

Lali, Mehdi

2010-01-01

Like Mars, Europa and Titan are worlds for which we have a special fascination. In the past two centuries, our curiosity has been stimulated by the possibility of the existence of life on Mars, and that it would be the first planet to be visited by humans. Nevertheless, there are several driving motivations that impel humans to survey Europa for astrobiological purposes and colonize Titan in order to utilize its resources. The biggest constraint for this manned spaceflight will however be the very long distances between Earth, Jupiter and Saturn. In consequence, this will lead to a very long mission duration which will be the main concern from the standpoint of human factors, especially based on our current technological capability in such fields. It is also important to note that all our eggs are currently in one basket like the dinosaurs before the extinction. If we do not make a push into space and all things go environmentally wrong, we will be just as extinct. This environmental exploration for such missions will help us save the planet and humans. In order to cut down on the mission duration, a fast transit method known as ``one-tangent-burn'' trajectory is recommended to be used instead of Hohmann transfer. But this will cost an increase in the required total ΔV. Most importantly, a rare launch-window opportunity is conceived to occur in 2078, in which these sites i.e. Mars, Europa and Titan will be aligned in such a way that they can be visited in one mission taking advantage of the gravity assists from Mars and Jupiter. This specific launch window will not recur for decades. The trajectories, orbits and planetary configurations both at the time of this launch window and arrival to these sites as well as the return missions are calculated and depicted by the computer programs designed in MATLAB for this purpose. Finally, it is shown that the gravity assist that the spacecraft receives at each swingby maneuver will drastically decrease the mission duration.

Evaluation of the Oxygen Concentrator Prototypes: Pressure Swing Adsorption Prototype and Electrochemical Prototype

NASA Technical Reports Server (NTRS)

Gilkey, Kelly M.; Olson, Sandra L.

2015-01-01

An oxygen concentrator is needed to provide enriched oxygen in support of medical contingency operations for future exploration human spaceflight programs. It would provide continuous oxygen to an ill or injured crew member in a closed cabin environment. Oxygen concentration technology is being pursued to concentrate oxygen from the ambient environment so oxygen as a consumable resource can be reduced. Because oxygen is a critical resource in manned spaceflight, using an oxygen concentrator to pull oxygen out of the ambient environment instead of using compressed oxygen can provide better optimization of resources. The overall goal of this project is to develop an oxygen concentrator module that minimizes the hardware mass, volume, and power footprint while still performing at the required clinical capabilities. Should a medical event occur that requires patient oxygenation, the release of 100 percent oxygen into a small closed cabin environment can rapidly raise oxygen levels to the vehicles fire limit. The use of an oxygen concentrator to enrich oxygen from the ambient air and concentrate it to the point where it can be used for medical purposes means no oxygen is needed from the ultra-high purity (99.5+% O2) oxygen reserve tanks. By not adding oxygen from compressed tanks to the cabin environment, oxygen levels can be kept below the vehicle fire limit thereby extending the duration of care provided to an oxygenated patient without environmental control system intervention to keep the cabin oxygen levels below the fire limits. The oxygen concentrator will be a Food and Drug Administration (FDA) clearable device. A demonstration unit for the International Space Station (ISS) is planned to verify the technology and provide oxygen capability. For the ISS, the demonstration unit should not exceed 10 kg (approximately 22 lb), which is the soft stowage mass limit for launch on resupply vehicles for the ISS. The unit's size should allow for transport within the spacecraft to an ill crewmember. The user interface needs to be designed for ease of use by the local care provider and with consideration to the limited amount of training available to the astronaut corps for medical equipment and procedures.

Thyroid function changes related to use of iodinated water in the U.S. Space Program.

PubMed

McMonigal, K A; Braverman, L E; Dunn, J T; Stanbury, J B; Wear, M L; Hamm, P B; Sauer, R L; Billica, R D; Pool, S L

2000-11-01

The National Aeronautics and Space Administration (NASA) has used iodination as a method of microbial disinfection of potable water systems in U.S. spacecraft and long-duration habitability modules. A review of thyroid function tests of NASA astronauts who had consumed iodinated water during spaceflight was conducted. Thyroid function tests of all past and present astronauts were reviewed. Medical records of astronauts with a diagnosis of thyroid disease were reviewed. Iodine consumption by space crews from water and food was determined. Serum thyroid-stimulating hormone (TSH) and urinary iodine excretion from space crews were measured following modification of the Space Shuttle potable water system to remove most of the iodine. Mean TSH significantly increased in 134 astronauts who had consumed iodinated water during spaceflight. Serum TSH, and urine iodine levels of Space Shuttle crewmembers who flew following modification of the potable water supply system to remove iodine did not show a statistically significant change. There was no evidence supporting association between clinical thyroid disease and the number of spaceflights, amount of iodine consumed, or duration of iodine exposure. It is suggested that pharmacological doses of iodine consumed by astronauts transiently decrease thyroid function, as reflected by elevated serum TSH values. Although adverse effects of excess iodine consumption in susceptible individuals are well documented, exposure to high doses of iodine during spaceflight did not result in a statistically significant increase in long-term thyroid disease in the astronaut population.

Manned Space Exploration Can Provide Great Scientific Benefits

NASA Astrophysics Data System (ADS)

Singer, S. Fred

2005-08-01

An AGU Council statement (NASA: Earth and space sciences at risk, available at http:// www.agu.org/sci_soc/policy/positions/ earthspace_risk.shtml) and an Eos editorial [Barron, 2005], addressing NASA's envisioned manned Moon-Mars initiative, implicitly assume a zero-sum situation between manned and unmanned space programs. They also imply that the NASA initiative will not contribute significantly to science but will ``impact on the current and future health of Earth and space science research.'' I wish to respond to these concerns. It is generally agreed that the International Space Station and shuttle program have limited value and need to be terminated. But one should not assume that funds freed up by elimination of manned programs will accrue to unmanned programs. On the contrary, without a manned component, NASA will probably cease to exist. Congress likely will not continue to fund unmanned planetary exploration over the long term, and Earth and space researchers will then have to compete for support with scientists using non-space techniques.

KSC-04pd1397

NASA Image and Video Library

2004-06-30

KENNEDY SPACE CENTER, FLA. - Kimberly Beck, a college trainee in Controlled Biological Systems in the Spaceflight and Life Sciences Training Program, is helping with growth studies supporting payload development. Behind her is part of the WONDER (Water Offset Nutrient Delivery Experiment) flight payload that is investigating hydroponic plant crop production in microgravity.

The Road to NASA

NASA Technical Reports Server (NTRS)

Meyers, Valerie

2010-01-01

This slide presentation describes the career path and projects that the author worked on during her internship at NASA. As a Graduate Student Research Program (GSRP) participant the assignments that were given include: Human Mesenchymal Stem Cell Research, Spaceflight toxicology, Lunar Airborne Dust Toxicity Advisory Group (LADTAG) and a special study at Devon Island.

KSC-04PD-1397

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. Kimberly Beck, a college trainee in Controlled Biological Systems in the Spaceflight and Life Sciences Training Program, is helping with growth studies supporting payload development. Behind her is part of the WONDER (Water Offset Nutrient Delivery Experiment) flight payload that is investigating hydroponic plant crop production in microgravity.

Eric Boe and Bob Behnken Dragon Tour

NASA Image and Video Library

2017-03-08

During a tour of SpaceX headquarters in Hawthorne, California, commercial crew astronauts Eric Boe, left, and Bob Behnken view the Crew Dragon on March 8, 2017. Crew Dragon is being developed and manufactured in partnership with NASA's Commercial Crew Program to return human spaceflight capabilities to the U.S.

Sub-orbital commercial human spaceflight and informed consent.

PubMed

Carminati, Maria-Vittoria; Griffith, Doug; Campbell, Mark R

2011-02-01

Commercial spaceflight is expected to rapidly develop in the near future. This will begin with sub-orbital missions and then progress to orbital flights. Technical informed consent of spaceflight participants is required by the commercial spaceflight operator for regulatory purposes. Additionally, though not required by regulation, the aerospace medicine professional involved in the medical screening of both spaceflight participants and crewmembers will be asked to assist operators in obtaining medical informed consent for liability purposes. The various federal and state regulations regarding informed consent for sub-orbital commercial spaceflight are evolving and are unfamiliar to most aerospace medical professionals and are reviewed and discussed.

Effects of 14 days of spaceflight and nine days of recovery on cell body size and succinate dehydrogenase activity of rat dorsal root ganglion neurons

NASA Technical Reports Server (NTRS)

Ishihara, A.; Ohira, Y.; Roy, R. R.; Nagaoka, S.; Sekiguchi, C.; Hinds, W. E.; Edgerton, V. R.

1997-01-01

The cross-sectional areas and succinate dehydrogenase activities of L5 dorsal root ganglion neurons in rats were determined after 14 days of spaceflight and after nine days of recovery. The mean and distribution of the cross-sectional areas were similar to age-matched, ground-based controls for both the spaceflight and for the spaceflight plus recovery groups. The mean succinate dehydrogenase activity was significantly lower in spaceflight compared to aged-matched control rats, whereas the mean succinate dehydrogenase activity was similar in age-matched control and spaceflight plus recovery rats. The mean succinate dehydrogenase activity of neurons with cross-sectional areas between 1000 and 2000 microns2 was lower (between 7 and 10%) in both the spaceflight and the spaceflight plus recovery groups compared to the appropriate control groups. The reduction in the oxidative capacity of a subpopulation of sensory neurons having relatively large cross-sectional areas immediately following spaceflight and the sustained depression for nine days after returning to 1 g suggest that the 0 g environment induced significant alterations in proprioceptive function.

High Voltage EEE Parts for EMA/EHA Applications on Manned Launch Vehicles

NASA Technical Reports Server (NTRS)

Griffin, Trent; Young, David

2011-01-01

The objective of this paper is an assessment of high voltage electronic components required for high horsepower electric thrust vector control (TVC) systems for human spaceflight launch critical application. The scope consists of creating of a database of available Grade 1 electrical, electronic and electromechanical (EEE) parts suited to this application, a qualification path for potential non-Grade 1 EEE parts that could be used in these designs, and pathfinder testing to validate aspects of the proposed qualification plan. Advances in the state of the art in high power electric power systems enable high horsepower electric actuators, such as the electromechnical actuator (EMA) and the electro-hydrostatic actuator (EHA), to be used in launch vehicle TVC systems, dramaticly reducing weight, complexity and operating costs. Designs typically use high voltage insulated gate bipolar transistors (HV-IGBT). However, no Grade 1 HV-IGBT exists and it is unlikely that market factors alone will produce such high quality parts. Furthermore, the perception of risk, the lack of qualification methodoloy, the absence of manned space flight heritage and other barriers impede the adoption of commercial grade parts onto the critical path. The method of approach is to identify high voltage electronic component types and key parameters for parts currently used in high horsepower EMA/EHA applications, to search for higher quality substitutes and custom manufacturers, to create a database for these parts, and then to explore ways to qualify these parts for use in human spaceflight launch critical application, including grossly derating and possibly treating hybrid parts as modules. This effort is ongoing, but results thus far include identification of over 60 HV-IGBT from four manufacturers, including some with a high reliability process flow. Voltage ranges for HV-IGBT have been identified, as has screening tests used to characterize HV-IGBT. BSI BS ISO 21350 Space systems Off-the-shelf item utilization, developed from Marshall Work Instruction MWI8060.1 OFF-THE-SHELF HARDWARE UTILIZATION IN FLIGHT HARDWARE DEVELOPMENTwas found to provide guidance for including commercial off-the-shelf (COTS) hardware for use in critical applications.

Catalyst for Expanding Human Spaceflight

NASA Technical Reports Server (NTRS)

Lueders, Kathryn L.

2014-01-01

History supplies us with many models of how and how not to commercialize an industry. This presentation draws parallels between industries with government roots, like the railroad, air transport, communications and the internet, and NASAs Commercial Crew Program. In these examples, government served as a catalyst for what became a booming industry. The building block approach the Commercial Crew Program is taking is very simple -- establish a need, laying the groundwork, enabling industry and legal framework.

NASA-Ames Life Sciences Flight Experiments program - 1980 status report

NASA Technical Reports Server (NTRS)

Berry, W. E.; Dant, C. C.; Macleod, G.; Williams, B. A.

1980-01-01

The paper deals with the ESA's Spacelab LSFE (Life Sciences Flight Experiments) program which, once operational, will provide new and unique opportunities to conduct research into the effects of spaceflight and weightlessness on living organisms under conditions approximating ground-based laboratories. Spacelab missions, launched at 18-month intervals, will enable scientists to test hypotheses from such disciplines as vestibular physiology, developmental biology, biochemistry, cell biology, plant physiology, and similar life sciences.

Extending technology-aided leisure and communication programs to persons with spinal cord injury and post-coma multiple disabilities.

PubMed

Lancioni, Giulio E; Singh, Nirbhay N; O'Reilly, Mark F; Sigafoos, Jeff; Ricciuti, Riccardo A; Trignani, Roberto; Oliva, Doretta; Signorino, Mario; D'Amico, Fiora; Sasanelli, Giovanni

2015-01-01

These two studies extended technology-aided programs to promote leisure and communication opportunities to a man with cervical spinal cord injury and a post-coma man with multiple disabilities. The studies involved the use of ABAB designs, in which A and B represented baseline and intervention phases, respectively. The programs focused on enabling the participants to activate songs, videos, requests, text messages, and telephone calls. These options were presented on a computer screen and activated through a small pressure microswitch by the man with spinal cord injury and a special touch screen by the post-coma man. To help the latter participant, who had no verbal skills, with requests and telephone calls, series of words and phrases were made available that he could activate in those situations. Data showed that both participants were successful in managing the programs arranged for them. The man with spinal cord injury activated mean frequencies of above five options per 10-min session. The post-coma man activated mean frequencies of about 12 options per 20-min session. Technology-aided programs for promoting leisure and communication opportunities might be successfully tailored to persons with spinal cord injury and persons with post-coma multiple disabilities. Implications for Rehabilitation Technology-aided programs may be critical to enable persons with pervasive motor impairment to engage in leisure activities and communication events independently. Persons with spinal cord injury, post-coma extended brain damage, and forms of neurodegenerative disease, such as amyotrophic lateral sclerosis, may benefit from those programs. The programs could be adapted to the participants' characteristics, both in terms of technology and contents, so as to improve their overall impact on the participants' functioning and general mood.

Biodiversity conservation, sustainable development, and the U.S. Man and the Biosphere Program: Past contributions and future directions

Treesearch

P. N. Manley; D. C. Hayes

2006-01-01

U.S. Man and the Biosphere (MAB) Program is part of the United Nations Educational, Scientific, and Cultural Organization (UNESCO) MAB program, and is one of six regional MAB programs that span the globe. The MAB Program was created in 1971 with the goal to explore, demonstrate, promote, and encourage harmonious relationships between people and their environments....

An Evidence-Based Approach To Exercise Prescriptions on ISS

NASA Technical Reports Server (NTRS)

Ploutz-Snyder, Lori

2009-01-01

This presentation describes current exercise countermeasures and exercise equipment for astronauts onboard the ISS. Additionally, a strategy for evaluating evidence supporting spaceflight exercise is described and a new exercise prescription is proposed. The current exercise regimen is not fully effective as the ISS exercise hardware does not allow for sufficient exercise intensity, the exercise prescription is adequate and crew members are noncompliant with the prescription. New ISS hardware is proposed, Advanced Resistance Exercise Device (ARED), which allows additional exercises, is instrumented for data acquisition and offers improved loading. The new T2 hardware offers a better harness and subject loading system, is instrumented to allow ground reaction force data, and offers improved speed. A strategy for developing a spaceflight exercise prescription is described and involves identifying exercise training programs that have been shown to maximize adaptive benefits of people exercising in both 0 and 1 g environments. Exercise intensity emerged as an important factor in maintaining physiologic adaptations in the spaceflight environment and interval training is suggested. New ISS exercise hardware should allow for exercise at intensities high enough to elicit adaptive responses. Additionally, new exercise prescriptions should incorporate higher intensity exercises and seek to optimize intensity, duration and frequency for greater efficiency.

A Model for Forecasting Enlisted Student IA Billet Requirements

DTIC Science & Technology

2016-03-01

Professional Apprentice Career Track PCS Permanent Change of Station PG Paygrade PFY Previous Fiscal Year POM Program Objectives Memorandum RCN Rating...paygrade levels contribute to fleet manning issues. Rating Control Number ( RCN ) Fit measures fleet manning levels for each community. Excess manning in one...lower RCN Fit levels. Second, authorized billets in TFMMS serve as the primary input for generating Enlisted Programmed Authorizations (EPA

Medical and surgical applications of space biosensor technology

NASA Astrophysics Data System (ADS)

Hines, John W.

1996-02-01

Researchers in space life sciences are rapidly approaching a technology impasse. Many of the critical questions on the impact of spaceflight on living systems simply cannot be answered with the limited available technologies. Research subjects, particularly small animal models like the rat, must be allowed to function relatively untended and unrestrained for long periods to fully reflect the impact of microgravity and spaceflight on their behavior and physiology. These requirements preclude the use of present hard-wired instrumentation techniques and limited data acquisition systems. Implantable sensors and miniaturized biotelemetry are the only means of capturing the fundamental and critical data. This same biosensor and biotelemetry technology has direct application to Earth-based medicine and surgery. Continuous, on-line data acquisition and improved measurement capabilities combined with the ease and flexibility offered by automated, wireless, and portable instruments and data systems, should provide a boon to the health care industry. Playing a key role in this technology revolution is the Sensors 2000! (S2K!) Program at NASA Ames Research Center. S2K!, in collaboration with space life sciences researchers and managers, provides an integrated capability for sensor technology development and applications, including advanced biosensor technology development, spaceflight hardware development, and technology transfer and commercialization. S2K! is presently collaborating on several spaceflight projects with dual-use medical applications. One prime example is a collaboration with the Fetal Treatment Center (FTC) at the University of California at San Francisco. The goal is to develop and apply implantable chemical sensor and biotelemetry technology to continuously monitor fetal patients during extra-uterine surgery, replacement into the womb, through birth and beyond. Once validated for ground use, the method will be transitioned to spaceflight applications to remotely monitor key biochemical parameters in flight animals. Successful application of NASA implantable biosensor and biotelemetry technologies should accelerate the advancement of this and other modern medical procedures while furthering the exploration of life in space.

The Challenges and Achievements in 50 Years of Human Spaceflight

NASA Astrophysics Data System (ADS)

Hawley, Steven A.

2012-01-01

On April 12, 1961 the era of human spaceflight began with the orbital flight of Cosmonaut Yuri Gagarin. On May 5, 1961 The United States responded with the launch of Alan Shepard aboard Freedom 7 on the first flight of Project Mercury. The focus of the first 20 years of human spaceflight was developing the fundamental operational capabilities and technologies required for a human mission to the Moon. The Mercury and Gemini Projects demonstrated launch and entry guidance, on-orbit navigation, rendezvous, extravehicular activity, and flight durations equivalent to a round-trip to the Moon. Heroes of this epoch included flight directors Chris Kraft, Gene Kranz, and Glynn Lunney along with astronauts like John Young, Jim Lovell, Tom Stafford, and Neil Armstrong. The "Race to the Moon” was eventually won by the United States with the landing of Apollo 11 on July 20, 1969. The Apollo program was truncated at 11 missions and a new system, the Space Shuttle, was developed which became the focus of the subsequent 30 years. Although never able to meet the flight rate or cost promises made in the 1970s, the Shuttle nevertheless left a remarkable legacy of accomplishment. The Shuttle made possible the launch and servicing of the Hubble Space Telescope and diverse activities such as life science research and classified national security missions. The Shuttle launched more than half the mass ever put into orbit and its heavy-lift capability and large payload bay enabled the on-orbit construction of the International Space Station. The Shuttle also made possible spaceflight careers for scientists who were not military test pilots - people like me. In this talk I will review the early years of spaceflight and share my experiences, including two missions with HST, from the perspective of a five-time flown astronaut and a senior flight operations manager.

Medical and surgical applications of space biosensor technology

NASA Technical Reports Server (NTRS)

Hines, J. W.

1996-01-01

Researchers in space life sciences are rapidly approaching a technology impasse. Many of the critical questions on the impact of spaceflight on living systems simply cannot be answered with the limited available technologies. Research subjects, particularly small animal models like the rat, must be allowed to function relatively untended and unrestrained for long periods to fully reflect the impact of microgravity and spaceflight on their behavior and physiology. These requirements preclude the use of present hard-wired instrumentation techniques and limited data acquisition systems. Implantable sensors and miniaturized biotelemetry are the only means of capturing the fundamental and critical data. This same biosensor and biotelemetry technology has direct application to Earth-based medicine and surgery. Continuous, on-line data acquisition and improved measurement capabilities combined with the ease and flexibility offered by automated, wireless, and portable instruments and data systems, should provide a boon to the health care industry. Playing a key role in this technology revolution is the Sensors 2000! (S2K!) Program at NASA Ames Research Center. S2K!, in collaboration with space life sciences researchers and managers, provides an integrated capability for sensor technology development and applications, including advanced biosensor technology development, spaceflight hardware development, and technology transfer and commercialization. S2K! is presently collaborating on several spaceflight projects with dual-use medical applications. One prime example is a collaboration with the Fetal Treatment Center (FTC) at the University of California at San Francisco. The goal is to develop and apply implantable chemical sensor and biotelemetry technology to continuously monitor fetal patients during extra-uterine surgery, replacement into the womb, through birth and beyond. Once validated for ground use, the method will be transitioned to spaceflight applications to remotely monitor key biochemical parameters in flight animals. Successful application of NASA implantable biosensor and biotelemetry technologies should accelerate the advancement of this and other modern medical procedures while furthering the exploration of life in space.

Genetic differentiation induced by spaceflight treatment of Cistanche deserticola and identification of inter-simple sequence repeat markers associated with its medicinal constituent contents

NASA Astrophysics Data System (ADS)

Wu, Y.; Yang, D. Y.; Tu, P. F.; Tian, Y. Z.; Guo, Y. H.; Wang, X. M.; Li, X. B.

2011-02-01

The dried, fleshy stems of Cistanche deserticola (Orobanchaceae) are popular tonics in Traditional Chinese Medicine (TCM) to treat the inability of kidney in expelling extra fluid in the body, causing fluid retention, and reform reproductive system. However, the wild plants of C. deserticola have become endangered due to habitat downsizing and over-harvesting for its medicinal usages. The present research was carried out for the following purposes: (1) promoting the space-breeding research; (2) providing molecular evidence for agricultural selective breeding; and (3) protecting this endangered herbal medicine and conserving its genetic resources.In this study, plants were cultivated from seeds specifically treated in spaceflight for seven days, and sampled to screen positive mutants and identify ISSR markers associated with their medicinal constituents. As a result, nine out of the 94 ISSR primers were showed high polymorphism, and a total of 118 bands were generated, of which 80 were polymorphic, ranging from 250 to 2600 bp. The spaceflight mutants were found to have lower coefficient of gene differentiation (Gst = 0.0269), and higher gene flow (Nm = 18.0740) than those of the controls (Gst = 0.2067 and Nm = 1.9185). The results demonstrated that most of the genetic variation were harnessed within populations (>97%). The Analysis of Molecular Variance (AMOVA) revealed high genetic variation within populations (88.03%) and low genetic differentiation among regions (-18.83%) and populations (30.79%), respectively. The results also indicated a profound difference between spaceflight condition and that on the earth. The unique vacuum environment of spaceflight was suggested to induce DNA mutation and various variations of C. deserticola. In addition, six particular ISSR markers were identified, cloned and sequenced; one of them, CA41939-934, was found positively correlated with acteoside with correlation coefficient values of 0.264 (P < 0.05). Our work may provide a valuable molecular evidence for establishing conservation strategies and space-breeding research program.

Manipulator system man-machine interface evaluation program. [technology assessment

NASA Technical Reports Server (NTRS)

Malone, T. B.; Kirkpatrick, M.; Shields, N. L.

1974-01-01

Application and requirements for remote manipulator systems for future space missions were investigated. A manipulator evaluation program was established to study the effects of various systems parameters on operator performance of tasks necessary for remotely manned missions. The program and laboratory facilities are described. Evaluation criteria and philosophy are discussed.

Software Engineering for Human Spaceflight

NASA Technical Reports Server (NTRS)

Fredrickson, Steven E.

2014-01-01

The Spacecraft Software Engineering Branch of NASA Johnson Space Center (JSC) provides world-class products, leadership, and technical expertise in software engineering, processes, technology, and systems management for human spaceflight. The branch contributes to major NASA programs (e.g. ISS, MPCV/Orion) with in-house software development and prime contractor oversight, and maintains the JSC Engineering Directorate CMMI rating for flight software development. Software engineering teams work with hardware developers, mission planners, and system operators to integrate flight vehicles, habitats, robotics, and other spacecraft elements. They seek to infuse automation and autonomy into missions, and apply new technologies to flight processor and computational architectures. This presentation will provide an overview of key software-related projects, software methodologies and tools, and technology pursuits of interest to the JSC Spacecraft Software Engineering Branch.

Nutritional criteria for closed-loop space food systems

NASA Technical Reports Server (NTRS)

Rambaut, P. C.

1980-01-01

The nutritional requirements for Skylab crews are summarized as a data base for long duration spaceflight nutrient requirements. Statistically significant increases in energy consumption were detected after three months, along with CO2/O2 exhalation during exercise and thyroxine level increases. Linoleic acid amounting to 3-4 g/day was found to fulfill all fat requirements, and carbohydrate and protein (amino acid) necessities are discussed, noting that vigorous exercise programs avoid deconditioning which enhances nitrogen loss. Urinary calcium losses continued at a rate 100% above a baseline figure, a condition which ingestion of vitamin D2 did not correct. Projections are given that spaceflights lasting more than eight years will necessitate recycling of human waste for nutrient growth, which can be processed into highly efficient space food with a variety of tastes.

RATANA MEEKHAM, AN ELECTRICAL INTEGRATION TECHNICIAN FOR QUALIS CORP. OF HUNTSVILLE, ALABAMA, HELPS TEST AVIONICS -- COMPLEX VEHICLE SYSTEMS ENABLING NAVIGATION, COMMUNICATIONS AND OTHER FUNCTIONS CRITICAL TO HUMAN SPACEFLIGHT

NASA Image and Video Library

2015-01-08

RATANA MEEKHAM, AN ELECTRICAL INTEGRATION TECHNICIAN FOR QUALIS CORP. OF HUNTSVILLE, ALABAMA, HELPS TEST AVIONICS -- COMPLEX VEHICLE SYSTEMS ENABLING NAVIGATION, COMMUNICATIONS AND OTHER FUNCTIONS CRITICAL TO HUMAN SPACEFLIGHT -- FOR THE SPACE LAUNCH SYSTEM PROGRAM AT NASA’S MARSHALL SPACE FLIGHT CENTER IN HUNTSVILLE, ALABAMA. HER WORK SUPPORTS THE NASA ENGINEERING & SCIENCE SERVICES AND SKILLS AUGMENTATION CONTRACT LED BY JACOBS ENGINEERING OF HUNTSVILLE. MEEKHAM WORKS FULL-TIME AT MARSHALL WHILE FINISHING HER ASSOCIATE'S DEGREE IN MACHINE TOOL TECHNOLOGY AT CALHOUN COMMUNITY COLLEGE IN DECATUR, ALABAMA. THE SPACE LAUNCH SYSTEM, NASA’S NEXT HEAVY-LIFT LAUNCH VEHICLE, IS THE WORLD’S MOST POWERFUL ROCKET, SET TO FLY ITS FIRST UNCREWED LUNAR ORBITAL MISSION IN 2018. ITS FIRST.

Modeling for Integrated Science Management and Resilient Systems Development

NASA Technical Reports Server (NTRS)

Shelhamer, M.; Mindock, J.; Lumpkins, S.

2014-01-01

Many physiological, environmental, and operational risks exist for crewmembers during spaceflight. An understanding of these risks from an integrated perspective is required to provide effective and efficient mitigations during future exploration missions that typically have stringent limitations on resources available, such as mass, power, and crew time. The Human Research Program (HRP) is in the early stages of developing collaborative modeling approaches for the purposes of managing its science portfolio in an integrated manner to support cross-disciplinary risk mitigation strategies and to enable resilient human and engineered systems in the spaceflight environment. In this talk, we will share ideas being explored from fields such as network science, complexity theory, and system-of-systems modeling. Initial work on tools to support these explorations will be discussed briefly, along with ideas for future efforts.

Overview of spaceflight immunology studies

NASA Technical Reports Server (NTRS)

Taylor, G. R.

1993-01-01

The effects of spaceflight and analogues of spaceflight are discussed here and in nine accompanying articles. In this summary we present spaceflight studies with human subjects, animal subjects, and cell cultures and we review ground-based systems used to model the observed effects of spaceflight on the immune system. Human paradigms include bed rest, academic or psychological stress, physical stress, hypobaric or high altitude stress, and confinement. Animal models include antiorthostatic and orthostatic suspension, hypobarism, and confinement. The ten manuscripts in this collection were selected to provide a summary that should give the reader an overview of the various activities of spaceflight immunology researchers throughout the history of space travel. This manuscript identifies the major contributors to the study of spaceflight immunology, explains what types of studies have been conducted, and how they have changed over the years. Also presented is a discussion of the unusual limitations associated with spaceflight research and the efforts to develop appropriate ground-based surrogate model systems. Specific details, data, and mechanistic speculations will be held to a minimum, because they will be discussed in depth in the other articles in the collection.

Shuttle Risk Progression: Use of the Shuttle Probabilistic Risk Assessment (PRA) to Show Reliability Growth

NASA Technical Reports Server (NTRS)

Hamlin, Teri L.

2011-01-01

It is important to the Space Shuttle Program (SSP), as well as future manned spaceflight programs, to understand the early mission risk and progression of risk as the program gains insights into the integrated vehicle through flight. The risk progression is important to the SSP as part of the documentation of lessons learned. The risk progression is important to future programs to understand reliability growth and the first flight risk. This analysis uses the knowledge gained from 30 years of operational flights and the current Shuttle PRA to calculate the risk of Loss of Crew and Vehicle (LOCV) at significant milestones beginning with the first flight. Key flights were evaluated based upon historical events and significant re-designs. The results indicated that the Shuttle risk tends to follow a step function as opposed to following a traditional reliability growth pattern where risk exponentially improves with each flight. In addition, it shows that risk can increase due to trading safety margin for increased performance or due to external events. Due to the risk drivers not being addressed, the risk did not improve appreciably during the first 25 flights. It was only after significant events occurred such as Challenger and Columbia, where the risk drivers were apparent, that risk was significantly improved. In addition, this paper will show that the SSP has reduced the risk of LOCV by almost an order of magnitude. It is easy to look back afte r 30 years and point to risks that are now obvious, however; the key is to use this knowledge to benefit other programs which are in their infancy stages. One lesson learned from the SSP is understanding risk drivers are essential in order to considerably reduce risk. This will enable the new program to focus time and resources on identifying and reducing the significant risks. A comprehensive PRA, similar to that of the Shuttle PRA, is an effective tool quantifying risk drivers if support from all of the stakeholders is given.

Astronomy and astrophysics for the 1980's, volume 1

NASA Technical Reports Server (NTRS)

1982-01-01

The programs recommended address the most significant questions that confront contemporary astronomy and fall into three general categories: prerequisites for research initiatives, including instrumentation and detectors, theory and data analysis, computational facilities, laboratory astrophysics, and technical support at ground-based observatories; programs including an Advanced X-ray Astrophysics Facility, a Very-Long Baseline Array, a Technology Telescope and a Large Deployable Reflector; and programs for study and development, including X-ray observatories in space, instruments for the detection of gravitational waves from astronomical objects, and long duration spaceflights of infrared telescopes. Estimated costs of these programs are provided.

Astronomy and astrophysics for the 1980's, volume 1

NASA Astrophysics Data System (ADS)

The programs recommended address the most significant questions that confront contemporary astronomy and fall into three general categories: prerequisites for research initiatives, including instrumentation and detectors, theory and data analysis, computational facilities, laboratory astrophysics, and technical support at ground-based observatories; programs including an Advanced X-ray Astrophysics Facility, a Very-Long Baseline Array, a Technology Telescope and a Large Deployable Reflector; and programs for study and development, including X-ray observatories in space, instruments for the detection of gravitational waves from astronomical objects, and long duration spaceflights of infrared telescopes. Estimated costs of these programs are provided.

Johnson Space Center Health and Medical Technical Authority

NASA Technical Reports Server (NTRS)

Fogarty, Jennifer A.

2010-01-01

1.HMTA responsibilities: a) Assure program/project compliance with Agency health and medical requirements at identified key decision points. b) Certify that programs/projects comply with Agency health and medical requirements prior to spaceflight missions. c) Assure technical excellence. 2. Designation of applicable NASA Centers for HMTA implementation and Chief Medical Officer (CMO) appointment. 3. Center CMO responsible for HMTA implementation for programs and projects at the center. JSC HMTA captured in "JSC HMTA Implementation Plan". 4. Establishes specifics of dissenting opinion process consistent with NASA procedural requirements.

Apollo experience report: Reliability and quality assurance

NASA Technical Reports Server (NTRS)

Sperber, K. P.

1973-01-01

The reliability of the Apollo spacecraft resulted from the application of proven reliability and quality techniques and from sound management, engineering, and manufacturing practices. Continual assessment of these techniques and practices was made during the program, and, when deficiencies were detected, adjustments were made and the deficiencies were effectively corrected. The most significant practices, deficiencies, adjustments, and experiences during the Apollo Program are described in this report. These experiences can be helpful in establishing an effective base on which to structure an efficient reliability and quality assurance effort for future space-flight programs.

NASA Exercise Physiology and Countermeasures Project Overview

NASA Technical Reports Server (NTRS)

Loerch, Linda; Ploutz-Snyder, Lori

2009-01-01

Efficient exercise countermeasures are necessary to offset or minimize spaceflight-induced deconditioning and to maximize crew performance of mission tasks. These countermeasure protocols should use the fewest crew and vehicle resources. NASA s Exercise Physiology and Countermeasures (ExPC) Project works to identify, collect, interpret, and summarize evidence that results in effective exercise countermeasure protocols which protect crew health and performance during International Space Station (ISS) and future exploration-class missions. The ExPC and NASA s Human Research Program are sponsoring multiple studies to evaluate and improve the efficacy of spaceflight exercise countermeasures. First, the Project will measure maximal aerobic capacity (VO2max) during cycle ergometry before, during, and after ISS missions. Second, the Project is sponsoring an evaluation of a new prototype harness that offers improved comfort and increased loading during treadmill operations. Third, the Functional Tasks Test protocol will map performance of anticipated lunar mission tasks with physiologic systems before and after short and long-duration spaceflight, to target system contributions and the tailoring of exercise protocols to maximize performance. In addition to these studies that are actively enrolling crewmember participants, the ExPC is planning new studies that include an evaluation of a higher-intensity/lower-volume exercise countermeasure protocol aboard the ISS using the Advanced Resistive Exercise Device and second-generation treadmill, studies that evaluate bone loading during spaceflight exercise, and ground-based studies that focus on fitness for duty standards required to complete lunar mission tasks and for which exercise protocols need to protect. Summaries of these current and future studies and strategies will be provided to international colleagues for knowledge sharing and possible collaboration.

Effects of microgravity on rat muscle

NASA Technical Reports Server (NTRS)

Riley, D. A.

1990-01-01

It is well known that humans exposed to long term spaceflight experience undesirable progressive muscle weakness and increased fatigability. This problem has prompted the implementation of inflight exercise programs because most investigators believe that the major cause of diminished muscle performance is a combination of disuse and decreased workload. Inflight exercise has improved muscle health, but deficits have persisted, indicating that either the regimens utilized were suboptimal or there existed additional debilitating factors which were not remedied by exercise. Clarification of this question requires an improved understanding of the cellular and molecular basis of spaceflight-induced muscle deterioration. To this end, multiple investigations have been performed on the muscles from rats orbited 5 to 22 days in Cosmos biosatellites and Spacelab-3 (2,4,5,8,10 to 14,16,18,19,21 to 23,25,27,28). The eight Cosmos 1887 investigations examined the structural and biochemical changes in skeletal and cardiac muscles of rats exposed to microgravity for 12.5 days and returned to terrestrial gravity 2.3 days before tissues were collected. Even though interpretation of these results was complicated by the combination of inflight and postflight induced alterations, the consensus is that there is marked heterogeneity in both degree and type of responses from the whole muscle level down to the molecular level. Collectively, the muscle investigations of Cosmos 1887 clearly illustrate the wide diversity of muscle tissue responses to spaceflight. Judging from the summary report of this mission, heterogeneity of responses is not unique to muscle tissue. Elucidating the mechanism underlying this heterogeneity holds the key to explaining adaptation of the organism to prolonged spaceflight.

Going Commercial

NASA Technical Reports Server (NTRS)

Walker, Charles

2005-01-01

while the conditions are more rigorous today for the ISS than they were in the very early days of space travel, opportunities still abound, and we just need to overcome the hurdles. As Pogo put it, "By gosh, we seem to be surrounded by an insurmountable opportunity here." This really is a great time in human spaceflight. We re doing marvelous things up there from an engineering standpoint. We now have to put them to good use. We need to optimize the 30 percent of the ISS that our federal government and the international partners have available in terms of the Station s power, volume, and crew time. Despite the recent issues with cost and schedule, as Mr. Goldin has said, this Agency will find a way. This country and the partners will find a way to restore the ISS s capability. We need help from this government, from our Congress, from our partners to do that, but it will be done, and then this facility is going to be world class--nah, it will out-of-this- world class. I m pleased to be a part of not only the history of spaceflight and the history of industry s participation in spaceflight, but I m also pleased to be a part of the future, the future applications, the future benefits that our spaceflight program is going to bring to our economy, to our careers, and to those of us that are both taxpayers and participants as well, to the great joy of seeing success as part of this country, as a part of our intellect, applied to the great beyond.

Reactivation and shedding of cytomegalovirus in astronauts during spaceflight

NASA Technical Reports Server (NTRS)

Mehta, S. K.; Stowe, R. P.; Feiveson, A. H.; Tyring, S. K.; Pierson, D. L.

2000-01-01

The reactivation of cytomegalovirus (CMV) in 71 astronauts was investigated, using polymerase chain reaction. A significantly greater (P<.0001) shedding frequency was found in urine samples from astronauts before spaceflight (10.6%) than in urine from the healthy control subject group (1.2%). Two of 4 astronauts studied during spaceflight shed CMV in urine. A significant increase (P<.0001) in CMV antibody titer, compared with baseline values, was also found 10 days before spaceflight. CMV antibody titer was further increased (P<.001) 3 days after landing, compared with 10 days before the mission. Significant increases in stress hormones were also found after landing. These results demonstrate that CMV reactivation occurred in astronauts before spaceflight and indicate that CMV may further reactivate during spaceflight.

Nutritional Biochemistry of Spaceflight

NASA Technical Reports Server (NTRS)

Smith, Scott M.

2000-01-01

Adequate nutrition is critical for crew health and safety during spaceflight. To ensure adequate nutrition, the nutrient requirements need to be both accurate and available from the spaceflight food system. The existing nutritional requirements for extended-duration spaceflight have been defined largely by extrapolation from ground-based research. However, nutritional requirements are influenced by most of the physiological consequences of spaceflight, including loss of lean, adipose, and bone tissue; changes in blood composition; and increased risk of renal stone formation. This review focuses on key areas where information has been gained in recent years: dietary intake and energy metabolism, bone health, fluid and electrolyte homeostasis, and hematological changes. Areas in which specific nutrients have the potential to serve as countermeasures to the negative effects of spaceflight are also reviewed. Dietary Intake

Comparison of the Physiology of the Spaceflight and Hindlimb Suspended Rat

NASA Technical Reports Server (NTRS)

Grindeland, R. E.; Booth, F. W.

1994-01-01

The suspended rat has been used extensively as a simulation of the spaceflight animal. In suspension, hindlimbs are unloaded from the acceleration of gravity, much as they are in spaceflight. Comparisons of data from spaceflight (microgravity) and suspended (1G) rats have suggested that suspension my be an appropriate model, but no direct comparisons had been made between the spaceflight and suspended rat. Cosmos 2044 afforded the first opportunity to directly compare the effects of hindlimb suspension (HS) and spaceflight (SF) on a broad range of physiological and histological parameters. This paper reports on the comparison of skelton, skeletal muscle, heart, neural, pulmonary, kidney, liver, intestine, blood plasma, immune function, red blood cells, and endocrine and reproductive functions and systems.

Authorized Course of Instruction for the Quinmester Program. Science: Introduction to Anatomy and Physiology; Human Reproduction; Man and Disease; Man's Senses; and Introduction to the Human Body.

ERIC Educational Resources Information Center

Dade County Public Schools, Miami, FL.

Performance objectives are stated for each of the five secondary school units included in this package of instructional guides prepared for the Dade County Florida Quinmester Program. All five units are concerned with aspects of physiology; three require no prerequisite study of biology ("Introduction to the Human Body,""Man and…

Human Spaceflight. Activities for the Primary Student. Aerospace Education Services Project.

ERIC Educational Resources Information Center

Hartsfield, John W.; Hartsfield, Kendra J.

Since its beginning, the space program has caught the attention of young people. This space science activity booklet was designed to provide information and learning activities for students in elementary grades. It contains chapters on: (1) primitive beliefs about flight; (2) early fantasies of flight; (3) the United States human spaceflight…

Cross-Compiler for Modeling Space-Flight Systems

NASA Technical Reports Server (NTRS)

James, Mark

2007-01-01

Ripples is a computer program that makes it possible to specify arbitrarily complex space-flight systems in an easy-to-learn, high-level programming language and to have the specification automatically translated into LibSim, which is a text-based computing language in which such simulations are implemented. LibSim is a very powerful simulation language, but learning it takes considerable time, and it requires that models of systems and their components be described at a very low level of abstraction. To construct a model in LibSim, it is necessary to go through a time-consuming process that includes modeling each subsystem, including defining its fault-injection states, input and output conditions, and the topology of its connections to other subsystems. Ripples makes it possible to describe the same models at a much higher level of abstraction, thereby enabling the user to build models faster and with fewer errors. Ripples can be executed in a variety of computers and operating systems, and can be supplied in either source code or binary form. It must be run in conjunction with a Lisp compiler.

KSC-2012-1828

NASA Image and Video Library

2012-03-09

CANOGA PARK, Calif. -- Pratt & Whitney Rocketdyne hot-fires a launch abort engine for The Boeing Co., which is developing its CST-100 spacecraft for NASA's Commercial Crew Program. Under its fixed-price contract with Boeing, Pratt and Whitney Rocketdyne is combining its Attitude Control Propulsion System thrusters from heritage spaceflight programs, Bantam abort engine design and storable propellant engineering capabilities. In 2011, NASA selected Boeing of Houston during Commercial Crew Development Round 2 CCDev2) activities to mature the design and development of a crew transportation system with the overall goal of accelerating a United States-led capability to the International Space Station. The goal of CCP is to drive down the cost of space travel as well as open up space to more people than ever before by balancing industry’s own innovative capabilities with NASA's 50 years of human spaceflight experience. Six other aerospace companies also are maturing launch vehicle and spacecraft designs under CCDev2, including Alliant Techsystems Inc. ATK, Blue Origin, Excalibur Almaz Inc., Sierra Nevada Corp., Space Exploration Technologies SpaceX, and United Launch Alliance ULA. For more information, visit www.nasa.gov/commercialcrew. Image credit: Pratt & Whitney Rocketdyne

KSC-2012-1829

NASA Image and Video Library

2012-03-09

CANOGA PARK, Calif. -- Pratt & Whitney Rocketdyne hot-fires a launch abort engine for The Boeing Co., which is developing its CST-100 spacecraft for NASA's Commercial Crew Program. Under its fixed-price contract with Boeing, Pratt and Whitney Rocketdyne is combining its Attitude Control Propulsion System thrusters from heritage spaceflight programs, Bantam abort engine design and storable propellant engineering capabilities. In 2011, NASA selected Boeing of Houston during Commercial Crew Development Round 2 CCDev2) activities to mature the design and development of a crew transportation system with the overall goal of accelerating a United States-led capability to the International Space Station. The goal of CCP is to drive down the cost of space travel as well as open up space to more people than ever before by balancing industry’s own innovative capabilities with NASA's 50 years of human spaceflight experience. Six other aerospace companies also are maturing launch vehicle and spacecraft designs under CCDev2, including Alliant Techsystems Inc. ATK, Blue Origin, Excalibur Almaz Inc., Sierra Nevada Corp., Space Exploration Technologies SpaceX, and United Launch Alliance ULA. For more information, visit www.nasa.gov/commercialcrew. Image credit: Pratt & Whitney Rocketdyne

KSC-2012-1827

NASA Image and Video Library

2012-03-09

CANOGA PARK, Calif. -- Pratt & Whitney Rocketdyne hot-fires a launch abort engine for The Boeing Co., which is developing its CST-100 spacecraft for NASA's Commercial Crew Program. Under its fixed-price contract with Boeing, Pratt and Whitney Rocketdyne is combining its Attitude Control Propulsion System thrusters from heritage spaceflight programs, Bantam abort engine design and storable propellant engineering capabilities. In 2011, NASA selected Boeing of Houston during Commercial Crew Development Round 2 CCDev2) activities to mature the design and development of a crew transportation system with the overall goal of accelerating a United States-led capability to the International Space Station. The goal of CCP is to drive down the cost of space travel as well as open up space to more people than ever before by balancing industry’s own innovative capabilities with NASA's 50 years of human spaceflight experience. Six other aerospace companies also are maturing launch vehicle and spacecraft designs under CCDev2, including Alliant Techsystems Inc. ATK, Blue Origin, Excalibur Almaz Inc., Sierra Nevada Corp., Space Exploration Technologies SpaceX, and United Launch Alliance ULA. For more information, visit www.nasa.gov/commercialcrew. Image credit: Pratt & Whitney Rocketdyne

Human Spaceflight Safety for the Next Generation on Orbital Space Systems

NASA Technical Reports Server (NTRS)

Mango, Edward J.

2011-01-01

The National Aeronautics and Space Administration (NASA) Commercial Crew Program (CCP) has been chartered to facilitate the development of a United States (U.S.) commercial crew space transportation capability with the goal of achieving safe, reliable, and cost effective access to and from low Earth orbit (LEO) and the International Space Station (ISS) as soon as possible. Once the capability is matured and is available to the Government and other customers, NASA expects to purchase commercial services to meet its ISS crew rotation and emergency return objectives. The primary role of the CCP is to enable and ensure safe human spaceflight and processes for the next generation of earth orbital space systems. The architecture of the Program delineates the process for investment performance in safe orbital systems, Crew Transportation System (CTS) certification, and CTS Flight Readiness. A series of six technical documents build up the architecture to address the top-level CTS requirements and standards. They include Design Reference Missions, with the near term focus on ISS crew services, Certification and Service Requirements, Technical Management Processes, and Technical and Operations Standards Evaluation Processes.

Sensors for spacecraft cabin environment monitoring

NASA Astrophysics Data System (ADS)

Ramsden, J. J.; Sharkan, Y. P.; Zhitov, N. B.; Korposh, S. O.

2007-10-01

It is very necessary, in manned spaceflight, to ensure that essential variables, including concentrations of oxygen, carbon dioxide, water vapour and volatile organic contaminants, are maintained within acceptable limits. Furthermore, the purity of drinking water, etc. must at all times be assured. Moreover, for lengthy voyages, the proliferation of bacteria and other microorganisms may need to be monitored. Here we present a platform approach to these problems based on multiplexed optical fibres sensitized to the different analytes by coating them with thin-film capture layers of bionanomaterial composites. Both amplitude and interference measurement modes are described, as well as a photoactivated amplitude measurement mode offering further sensitivity enhancement. It is a great and novel advantage that the same technology, and hence the same data processing and diagnostics procedures, can be used over a vast range of analytes in both gaseous and liquid media.

Advanced solid electrolyte cell for CO2 and H2O electrolysis. [for extended duration manned spaceflights

NASA Technical Reports Server (NTRS)

Shumar, J. W.; Berger, T. A.

1978-01-01

A solid electrolyte cell with improved sealing characteristics was examined. A tube cell was designed, developed, fabricated, and tested. Design concepts incorporated in the tube cell to improve its sealing capability included minimizing the number of seals per cell and moving seals to lower temperature regions. The advanced tube cell design consists of one high temperature ceramic cement seal, one high temperature gasket seal, and three low temperature silicone elastomer seals. The two high temperature seals in the tube cell design represent a significant improvement over the ten high temperature precious metal seals required by the electrolyzer drum design. For the tube cell design the solid electrolyte was 8 mole percent yttria stabilized zirconium oxide slip cast into the shape of a tube with electrodes applied on the inside and outside surfaces.

Effects of the space flight environment on man's immune system. II - Lymphocyte counts and reactivity.

NASA Technical Reports Server (NTRS)

Fischer, G. L.; Daniels, J. C.; Levin, W. C.; Kimzey, S. L.; Cobb, E. K.; Ritzmann, S. E.

1972-01-01

The present studies were undertaken to assess the effects of the environment of space flights on the cellular division of the human immune system. Peripheral blood absolute lymphocyte counts were determined at various preflight and postflight intervals for the 21 crewmen of Apollo Missions 7-13. Mean lymphocyte numbers tended to exhibit a delayed significant but fluctuating increase shortly after recovery, although a variety of responses was seen in individual astronauts. The in vitro reactivity of lymphocytes, reflected by RNA and DNA synthesis rates by unstimulated and PHA-stimulated lymphocytes tissue-cultured preflight and postflight from the same participants, was found to remain within previously established normal ranges. These results indicate that functional integrity of cellular immune potential as reflected by in vitro techniques is maintained during this spaceflight experience.

Conference on Correlations of Aging and Space Effects on Biosystems, Oct. 30-Nov. 1, 1989, Proceedings

NASA Technical Reports Server (NTRS)

Sprott, Richard L. (Editor); Combs, Carol A. (Editor)

1991-01-01

This volume includes papers on correlations between aging effects and space effects on biosystems, with particular attention given to the effects on the cardiovascular system, bone, sleep, cellular systems, immunological system, and genetics. Papers are presented on NASA and NIA plans and opportunities, the age effect on the posture and circulation, the cardiovascular physiology in space flight, and age-related bone changes. Attention is given to research on sleep, circulation rhythms, and aging and its applications to manned spaceflight; sleep and circadian rhythms; altered cell function in microgravity; and the heterogeneity of changes in lymphoproliferative ability with increasing age. Also included is a review of cellular immunosenescence, a paper on the immune response during space flight, and a paper on Caenorhabditis elegans as a model system for space biology studies.

Bone loss and human adaptation to lunar gravity

NASA Technical Reports Server (NTRS)

Keller, T. S.; Strauss, A. M.

1992-01-01

Long-duration space missions and establishment of permanently manned bases on the Moon and Mars are currently being planned. The weightless environment of space and the low-gravity environments of the Moon and Mars pose an unknown challenge to human habitability and survivability. Of particular concern in the medical research community today is the effect of less than Earth gravity on the human skeleton, since the limits, if any, of human endurance in low-gravity environments are unknown. This paper provides theoretical predictions on bone loss and skeletal adaptation to lunar and other nonterrestrial-gravity environments based upon the experimentally derived relationship, density approximately (mass x gravity)(exp 1/8). The predictions are compared to skeletal changes reported during bed rest, immobilization, certrifugation, and spaceflight. Countermeasures to reduce bone losses in fractional gravity are also discussed.

The MASSE Project: Applications of Biotechnology for Planetary Exploration

NASA Technical Reports Server (NTRS)

Lynch, Kennda; Steele, Andrew; Hedgecock, Jud; Wainwright, Norm; McKay, David S.; Maule, Jake; Schweitzer, Mary

2003-01-01

Automated life-detection experiments for solar system exploration have been previously. proposed and used onboard the. Viking, Mars lander,s, although. with ambiguous results. The recent advances in biotechnology such as biosensors, protein microarrays, and microfluidics alongside increased. knowledge in biomarker science have led to vastly improved sophistication and sensitivity for a new approach in life detection. The MASSE project has taken the challenge of integrating all of this knowledge into a new generation of interplanetary flight instrumentation for the main purpose.ot combining several mutually. confirming tests for life, organic/microbial contamination, prebiotic and abiotic chemicals into a small low powered instrument. Although the primary goal is interplanetary exploration, several terrestrial applications have become apparent specifically in point-of-care medical technology, bio-warfare, environmental sensing and microbial monitoring of manned space-flight vehicles.

Heliophysics: Space Storms and Radiation: Causes and Effects

NASA Astrophysics Data System (ADS)

Schrijver, Carolus J.; Siscoe, George L.

2010-05-01

Preface; 1. Perspective on heliophysics George L. Siscoe and Carolus J. Schrijver; 2. Introduction to space storms and radiation Sten Odenwald; 3. In-situ detection of energetic particles George Gloeckler; 4. Radiative signatures of energetic particles Tim Bastian; 5. Observations of solar and stellar eruptions, flares, and jets Hugh Hudson; 6. Models of coronal mass ejections and flares Terry Forbes; 7. Shocks in heliophysics Merav Opher; 8. Particle acceleration in shocks Dietmar Krauss-Varban; 9. Energetic particle transport Joe Giacalone; 10. Energy conversion in planetary magnetospheres Vytenis Vasyliunas; 11. Energization of trapped particles Janet Green; 12. Flares, CMEs, and atmospheric responses Tim Fuller-Rowell and Stanley C. Solomon; 13. Energetic particles and manned spaceflight 358 Stephen Guetersloh and Neal Zapp; 14. Energetic particles and technology Alan Tribble; Appendix I. Authors and editors; List of illustrations; List of tables; Bibliography; Index.

Heliophysics: Space Storms and Radiation: Causes and Effects

NASA Astrophysics Data System (ADS)

Schrijver, Carolus J.; Siscoe, George L.

2012-01-01

Preface; 1. Perspective on heliophysics George L. Siscoe and Carolus J. Schrijver; 2. Introduction to space storms and radiation Sten Odenwald; 3. In-situ detection of energetic particles George Gloeckler; 4. Radiative signatures of energetic particles Tim Bastian; 5. Observations of solar and stellar eruptions, flares, and jets Hugh Hudson; 6. Models of coronal mass ejections and flares Terry Forbes; 7. Shocks in heliophysics Merav Opher; 8. Particle acceleration in shocks Dietmar Krauss-Varban; 9. Energetic particle transport Joe Giacalone; 10. Energy conversion in planetary magnetospheres Vytenis Vasyliūnas; 11. Energization of trapped particles Janet Green; 12. Flares, CMEs, and atmospheric responses Tim Fuller-Rowell and Stanley C. Solomon; 13. Energetic particles and manned spaceflight 358 Stephen Guetersloh and Neal Zapp; 14. Energetic particles and technology Alan Tribble; Appendix I. Authors and editors; List of illustrations; List of tables; Bibliography; Index.

Cadre Photos for Joint Test Team Feature

NASA Image and Video Library

2017-02-23

During a tour of SpaceX headquarters in Hawthorne, California, commercial crew astronauts Bob Behnken, left, and Eric Boe participate in joint test team training using mockup components of the Crew Dragon on Feb. 23, 2017. Mike Good, program manager for Crew Operations and Testing at Johnson Space Center in Houston, is in the background. Crew Dragon is being developed and manufactured in partnership with NASA's Commercial Crew Program to return human spaceflight capabilities to the U.S.

Silkworm feeding as the source of the animal protein for human

NASA Astrophysics Data System (ADS)

Yunan, Y.; Tang, L.; Liu, H.

Controlled Ecological Life-Support System CELSS which is also called Bioregenerative Life Support System has been considered now as the most advanced and complicated Closed Ecological System in the world Based on the construction principle of the CELSS the resources could be permanently regenerated so the flexibility and security for long-term spaceflight and lunar-base missions could be improved The cost could be also decreased CELSS is more appropriated for long-term manned spaceflight and applied for the possibility of long-term space missions or planetary probe in the lower cost The increasing closure and reliability is considered as the development and integrality direction of Life-Support System LSS The LSS closure and configuration is mainly depended on the human space diet composition Vast researches have been carried on this aspect but these researches mainly concentrate on the space vegetable protein exploitation The animal protein supply is still a problem the solution should be found and the LSS constitution analysis also deserves being explored Many animals have been taken into account to provide the animal proteins nowadays world-wide animals selection mainly focus on the poultry for instance sheep chicken fish etc But the poultry feeding exist many problems such as the long growth periods low efficiency complex feeding procedures and capacious feeding space and these animals also cause the water and air pollution The complete food composition is often depended on the features of the nation diet habit Chinese have

On Representative Spaceflight Instrument and Associated Instrument Sensor Web Framework

NASA Technical Reports Server (NTRS)

Kizhner, Semion; Patel, Umeshkumar; Vootukuru, Meg

2007-01-01

Sensor Web-based adaptation and sharing of space flight mission resources, including those of the Space-Ground and Control-User communication segment, could greatly benefit from utilization of heritage Internet Protocols and devices applied for Spaceflight (SpaceIP). This had been successfully demonstrated by a few recent spaceflight experiments. However, while terrestrial applications of Internet protocols are well developed and understood (mostly due to billions of dollars in investments by the military and industry), the spaceflight application of Internet protocols is still in its infancy. Progress in the developments of SpaceIP-enabled instrument components will largely determine the SpaceIP utilization of those investments and acceptance in years to come. Likewise SpaceIP, the development of commercial real-time and instrument colocated computational resources, data compression and storage, can be enabled on-board a spacecraft and, in turn, support a powerful application to Sensor Web-based design of a spaceflight instrument. Sensor Web-enabled reconfiguration and adaptation of structures for hardware resources and information systems will commence application of Field Programmable Arrays (FPGA) and other aerospace programmable logic devices for what this technology was intended. These are a few obvious potential benefits of Sensor Web technologies for spaceflight applications. However, they are still waiting to be explored. This is because there is a need for a new approach to spaceflight instrumentation in order to make these mature sensor web technologies applicable for spaceflight. In this paper we present an approach in developing related and enabling spaceflight instrument-level technologies based on the new concept of a representative spaceflight Instrument Sensor Web (ISW).

Vitamin K Status in Spaceflight and Ground-Based Models of Spaceflight

PubMed Central

Zwart, Sara R; Booth, Sarah L; Peterson, James W; Wang, Zuwei; Smith, Scott M

2011-01-01

Bone loss is a well-documented change during and after long-duration spaceflight. Many types of countermeasures to bone loss have been proposed, including vitamin K supplementation. The objective of this series of studies was to measure change in vitamin K status in response to microgravity under a variety of spaceflight and spaceflight analog (model) conditions, including long-duration spaceflight studies (n = 15), three bed rest studies (n = 15, 49, and 24), and a 14-day saturation dive (n= 6). In crew members who flew 2–6 months on the International Space Station, in-flight and postflight plasma phylloquinone concentrations were unchanged from the preflight mean. Consistent with this finding, urinary γ-carboxyglutamic acid (GLA), a measure of vitamin K-dependent protein turnover, did not change in response to flight. Serum undercarboxylated osteocalcin (%ucOC), a measure of vitamin K function, was generally unchanged in response to flight. Spaceflight findings were corroborated by findings of no changes in phylloquinone, urinary GLA, or %ucOC during or after bed rest in three separate bed rest studies (21–90 days in duration) or after a 14-day saturation dive. The data presented here do not support either a need for vitamin K supplementation during spaceflight or the suggestion of using vitamin K as a bone loss countermeasure in spaceflight. © 2011 American Society for Bone and Mineral Research. PMID:21541997

Crewmember Performance Before, During, And After Spaceflight

PubMed Central

Kelly, Thomas H; Hienz, Robert D; Zarcone, Troy J; Wurster, Richard M; Brady, Joseph V

2005-01-01

The development of technologies for monitoring the welfare of crewmembers is a critical requirement for extended spaceflight. Behavior analytic methodologies provide a framework for studying the performance of individuals and groups, and brief computerized tests have been used successfully to examine the impairing effects of sleep, drug, and nutrition manipulations on human behavior. The purpose of the present study was to evaluate the feasibility and sensitivity of repeated performance testing during spaceflight. Four National Aeronautics and Space Administration crewmembers were trained to complete computerized questionnaires and performance tasks at repeated regular intervals before and after a 10-day shuttle mission and at times that interfered minimally with other mission activities during spaceflight. Two types of performance, Digit-Symbol Substitution trial completion rates and response times during the most complex Number Recognition trials, were altered slightly during spaceflight. All other dimensions of the performance tasks remained essentially unchanged over the course of the study. Verbal ratings of Fatigue increased slightly during spaceflight and decreased during the postflight test sessions. Arousal ratings increased during spaceflight and decreased postflight. No other consistent changes in rating-scale measures were observed over the course of the study. Crewmembers completed all mission requirements in an efficient manner with no indication of clinically significant behavioral impairment during the 10-day spaceflight. These results support the feasibility and utility of computerized task performances and questionnaire rating scales for repeated measurement of behavior during spaceflight. PMID:16262187

Microbiological Lessons Learned from the Space Shuttle

NASA Technical Reports Server (NTRS)

Pierson, Duane L.; Ott, C. Mark; Bruce, Rebekah; Castro, Victoria A.; Mehta, Satish K.

2011-01-01

After 30 years of being the centerpiece of NASA s human spacecraft, the Space Shuttle will retire. This highly successful program provided many valuable lessons for the International Space Station (ISS) and future spacecraft. Major microbiological risks to crewmembers include food, water, air, surfaces, payloads, animals, other crewmembers, and ground support personnel. Adverse effects of microorganisms are varied and can jeopardize crew health and safety, spacecraft systems, and mission objectives. Engineering practices and operational procedures can minimize the negative effects of microorganisms. To minimize problems associated with microorganisms, appropriate steps must begin in the design phase of new spacecraft or space habitats. Spacecraft design must include requirements to control accumulation of water including humidity, leaks, and condensate on surfaces. Materials used in habitable volumes must not contribute to microbial growth. Use of appropriate materials and the implementation of robust housekeeping that utilizes periodic cleaning and disinfection will prevent high levels of microbial growth on surfaces. Air filtration can ensure low levels of bioaerosols and particulates in the breathing air. The use of physical and chemical steps to disinfect drinking water coupled with filtration can provide safe drinking water. Thorough preflight examination of flight crews, consumables, and the environment can greatly reduce pathogens in spacecraft. The advances in knowledge of living and working onboard the Space Shuttle formed the foundation for environmental microbiology requirements and operations for the International Space Station (ISS) and future spacecraft. Research conducted during the Space Shuttle Program resulted in an improved understanding of the effects of spaceflight on human physiology, microbial properties, and specifically the host-microbe interactions. Host-microbe interactions are substantially affected by spaceflight. Astronaut immune functions were found to be altered. Selected microorganisms were found to become more virulent during spaceflight. The increased knowledge gained on the Space Shuttle resulted in further studies of the host-microbe interactions on the ISS to determine if countermeasures were necessary. Lessons learned from the Space Shuttle Program were integrated into the ISS resulting in the safest space habitat to date.

Monitoring of Microbial Loads During Long Duration Missions as a Risk Reduction Tool

NASA Astrophysics Data System (ADS)

Roman, M. C.; Mena, K. D.

2012-01-01

Humans have been exploring space for more than 40 years. For all those years, microorganisms have accompanied both un-manned spacecraft/cargo and manned vessels. Microorganisms are everywhere on Earth, could easily adapt to new environments, and/or can rapidly mutate to survive in very harsh conditions. Their presence in spacecraft and cargo have caused a few inconveniences over the years of human spaceflight, ranging from crew health, life support systems challenges, and material degradation. The sterilization of spacecraft that will host humans in long duration mission would be a costly operation that will not provide a long-term solution to the microbial colonization of the vessels. As soon as a human is exposed to the spacecraft, microorganisms start populating the new environment during the mission. As the human presence in space increases in length, the risk from the microbial load to hardware and crew will also increase. Mitigation of this risk involves several different strategies that will include minimizing the microbial load (in numbers and diversity) and monitoring. This paper will provide a list of the risk mitigation strategies that should be implemented during ground processing, and during the mission. It will also discuss the areas that should be reviewed before an effective in-flight microbial monitoring regimen is implemented.

James Webb Space Telescope in NASA's giant thermal vacuum chamber

NASA Image and Video Library

2015-04-20

Inside NASA's giant thermal vacuum chamber, called Chamber A, at NASA's Johnson Space Center in Houston, the James Webb Space Telescope's Pathfinder backplane test model, is being prepared for its cryogenic test. Previously used for manned spaceflight missions, this historic chamber is now filled with engineers and technicians preparing for a crucial test. Exelis developed and installed the optical test equipment in the chamber. "The optical test equipment was developed and installed in the chamber by Exelis," said Thomas Scorse, Exelis JWST Program Manager. "The Pathfinder telescope gives us our first opportunity for an end-to-end checkout of our equipment." "This will be the first time on the program that we will be aligning two primary mirror segments together," said Lee Feinberg, NASA Optical Telescope Element Manager. "In the past, we have always tested one mirror at a time but this time we will use a single test system and align both mirrors to it as though they are a single monolithic mirror." The James Webb Space Telescope is the scientific successor to NASA's Hubble Space Telescope. It will be the most powerful space telescope ever built. Webb is an international project led by NASA with its partners, the European Space Agency and the Canadian Space Agency. Image credit: NASA/Chris Gunn Text credit: Laura Betz, NASA's Goddard Space Flight Center, Greenbelt, Maryland NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

International Cooperation in the Field of International Space Station (ISS) Payload Safety

NASA Astrophysics Data System (ADS)

Grayson, C.; Sgobba, T.; Larsen, A.; Rose, S.; Heimann, T.; Ciancone, M.; Mulhern, V.

2005-12-01

In the frame of the International Space Station (ISS) Program cooperation, in 1998 the European Space Agency (ESA) approached the National Aeronautics and Space Administration (NASA) with the unique concept of a Payload Safety Review Panel (PSRP) "franchise" based at the European Space Technology Center (ESTEC), where the panel would be capable of autonomously reviewing flight hardware for safety. This paper will recount the course of an ambitious idea as it progressed into a fully functional reality. It will show how a panel initially conceived at NASA to serve a national programme has evolved into an international safety cooperation asset. The PSRP established at NASA began reviewing ISS payloads approximately in late 1994 or early 1995 as an expansion of the pre- existing Shuttle Program PSRP. This paper briefly describes the fundamental Shuttle safety process and the establishment of the safety requirements for payloads intending to use the Space Transportation System and ISS. The paper will also offer some historical statistics about the experiments that completed the payload safety process for Shuttle and ISS. The paper then presents the background of ISS agreements and international treaties that had to be considered when establishing the ESA PSRP. The paper will expound upon the detailed franchising model, followed by an outline of the cooperation charter approved by the NASA Associate Administrator, Office of Space Flight, and ESA Director of Manned Spaceflight and Microgravity. The paper will then address the resulting ESA PSRP implementation and its success statistics to date. Additionally, the paper presents ongoing developments with the Japan Aerospace Exploration Agency (JAXA). The discussion will conclude with ideas for future developments, such to achieve a fully integrated international system of payload safety panels for ISS.

International Cooperation in the Field of International Space Station (ISS) Payload Safety

NASA Technical Reports Server (NTRS)

Heimann, Timothy; Larsen, Axel M.; Rose, Summer; Sgobba, Tommaso

2005-01-01

In the frame of the International Space Station (ISS) Program cooperation, in 1998, the European Space Agency (ESA) approached the National Aeronautics and Space Administration (NASA) with the unique concept of a Payload Safety Review Panel (PSRP) "franchise" based at the European Space Technology Center (ESTEC), where the panel would be capable of autonomously reviewing flight hardware for safety. This paper will recount the course of an ambitious idea as it progressed into a fully functional reality. It will show how a panel initially conceived at NASA to serve a national programme has evolved into an international safety cooperation asset. The PSRP established at NASA began reviewing ISS payloads approximately in late 1994 or early 1995 as an expansion of the pre-existing Shuttle Program PSRP. This paper briefly describes the fundamental Shuttle safety process and the establishment of the safety requirements for payloads intending to use the Space Transportation System and International Space Station (ISS). The paper will also offer some historical statistics about the experiments that completed the payload safety process for Shuttle and ISS. The paper 1 then presents the background of ISS agreements and international treaties that had to be taken into account when establishing the ESA PSRP. The detailed franchising model will be expounded upon, followed by an outline of the cooperation charter approved by the NASA Associate Administrator, Office of Space Flight, and ESA Director of Manned Spaceflight and Microgravity. The resulting ESA PSRP implementation and its success statistics to date will then be addressed. Additionally the paper presents the ongoing developments with the Japan Aerospace Exploration Agency. The discussion will conclude with ideas for future developments, such to achieve a fully integrated international system of payload safety panels for ISS.

Scripted Reading Programs: Fishing for Success

ERIC Educational Resources Information Center

Duncan-Owens, Deborah

2009-01-01

"Give a man a fish and he will eat for a day. Teach a man to fish and he will eat for the rest of his life." This popular Chinese proverb is an apt metaphor for the dilemma faced by principals and curriculum coordinators when deciding whether to purchase a scripted commercial reading program. Although a scripted reading program may solve…

CaveMan Enterprise version 1.0 Software Validation and Verification.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hart, David

The U.S. Department of Energy Strategic Petroleum Reserve stores crude oil in caverns solution-mined in salt domes along the Gulf Coast of Louisiana and Texas. The CaveMan software program has been used since the late 1990s as one tool to analyze pressure mea- surements monitored at each cavern. The purpose of this monitoring is to catch potential cavern integrity issues as soon as possible. The CaveMan software was written in Microsoft Visual Basic, and embedded in a Microsoft Excel workbook; this method of running the CaveMan software is no longer sustainable. As such, a new version called CaveMan Enter- prisemore » has been developed. CaveMan Enterprise version 1.0 does not have any changes to the CaveMan numerical models. CaveMan Enterprise represents, instead, a change from desktop-managed work- books to an enterprise framework, moving data management into coordinated databases and porting the numerical modeling codes into the Python programming language. This document provides a report of the code validation and verification testing.« less

NASA Developmental Biology Workshop: A summary

NASA Technical Reports Server (NTRS)

Souza, K. A. (Editor); Halstead, T. W. (Editor)

1985-01-01

The Life Sciences Division of the National Aeronautics and Space Administration (NASA) as part of its continuing assessment of its research program, convened a workshop on Developmental Biology to determine whether there are important scientific studies in this area which warrant continued or expanded NASA support. The workshop consisted of six panels, each of which focused on a single major phylogenetic group. The objectives of each panel were to determine whether gravity plays a role in the ontogeny of their subject group, to determine whether the microgravity of spaceflight can be used to help understand fundamental problems in developmental biology, to develop the rationale and hypotheses for conducting NASA-relevant research in development biology both on the ground and in space, and to identify any unique equipment and facilities that would be required to support both ground-based and spaceflight experiments.

KSC-2012-6553

NASA Image and Video Library

2012-09-28

HOUSTON -- NASA Astronaut Lee Archambault performs an evaluation of reach and visibility of controls and displays during an end-of-year interior layout evaluation of The Boeing Company's CST-100 spacecraft. The evaluation at Boeing's Houston Product Support Center in Texas was part of the company's ongoing work supporting its funded Space Act Agreement with NASA's Commercial Crew Program, or CCP, during the Commercial Crew Integrated Capability, or CCiCap, initiative. CCP is intended to lead to the availability of commercial human spaceflight services for government and commercial customers to low-Earth orbit. Future development and certification initiatives eventually will lead to the availability of human spaceflight services for NASA to send its astronauts to the International Space Station, where critical research is taking place daily. For more information about CCP, go to http://www.nasa.gov/commercialcrew. Photo credit: Boeing

Science and the Constellation Systems Program Office

NASA Technical Reports Server (NTRS)

Mendell, Wendell

2007-01-01

An underlying tension has existed throughout the history of NASA between the human spaceflight programs and the external scientific constituencies of the robotic exploration programs. The large human space projects have been perceived as squandering resources that might otherwise be utilized for scientific discoveries. In particular, the history of the relationship of science to the International Space Station Program has not been a happy one. The leadership of the Constellation Program Office, created in NASA in October, 2005, asked me to serve on the Program Manager s staff as a liaison to the science community. Through the creation of my position, the Program Manager wanted to communicate and elucidate decisions inside the program to the scientific community and, conversely, ensure that the community had a voice at the highest levels within the program. Almost all of my technical contributions at NASA, dating back to the Apollo Program, has been within the auspices of what is now known as the Science Mission Directorate. However, working at the Johnson Space Center, where human spaceflight is the principal activity, has given me a good deal of incidental contact and some more direct exposure through management positions to the structures and culture of human spaceflight programs. I entered the Constellation family somewhat naive but not uninformed. In addition to my background in NASA science, I have also written extensively over the past 25 years on the topic of human exploration of the Moon and Mars. (See, for example, Mendell, 1985). I have found that my scientific colleagues generally have little understanding of the structure and processes of a NASA program office; and many of them do not recognize the name, Constellation. In many respects, the international ILEWG community is better informed. Nevertheless, some NASA decision processes on the role of science, particularly with respect to the formulation of a lunar surface architecture, are not well known, even in ILEWG. At the recent annual Lunar and Planetary Science Conference, I reviewed the evolution of the program as a function of Agency leadership and the constraints put on NASA by the President in his 2004 announcement. I plan to continue my long-time ILEWG tradition of reporting a personal view of the state of development of human exploration of the solar system, this time coming from within the program office tasked to implement the vision for the United States. The current NASA implementation of the Vision for Space Exploration is consistent with certain classical scenarios that have been discussed extensively in the literature. I will discuss the role of science within the Vision, both from official policy and from a de facto interaction. While science goals are not officially driving the implementation of the Vision, the tools of scientific exploration are integral to defining the extraterrestrial design environments. In this respect the sharing of results from international missions to the Moon can make significant contributions to the success of the future human activities.

Effects of spaceflight on murine skeletal muscle gene expression

PubMed Central

Allen, David L.; Bandstra, Eric R.; Harrison, Brooke C.; Thorng, Seiha; Stodieck, Louis S.; Kostenuik, Paul J.; Morony, Sean; Lacey, David L.; Hammond, Timothy G.; Leinwand, Leslie L.; Argraves, W. Scott; Bateman, Ted A.; Barth, Jeremy L.

2009-01-01

Spaceflight results in a number of adaptations to skeletal muscle, including atrophy and shifts toward faster muscle fiber types. To identify changes in gene expression that may underlie these adaptations, we used both microarray expression analysis and real-time polymerase chain reaction to quantify shifts in mRNA levels in the gastrocnemius from mice flown on the 11-day, 19-h STS-108 shuttle flight and from normal gravity controls. Spaceflight data also were compared with the ground-based unloading model of hindlimb suspension, with one group of pure suspension and one of suspension followed by 3.5 h of reloading to mimic the time between landing and euthanization of the spaceflight mice. Analysis of microarray data revealed that 272 mRNAs were significantly altered by spaceflight, the majority of which displayed similar responses to hindlimb suspension, whereas reloading tended to counteract these responses. Several mRNAs altered by spaceflight were associated with muscle growth, including the phosphatidylinositol 3-kinase regulatory subunit p85α, insulin response substrate-1, the forkhead box O1 transcription factor, and MAFbx/atrogin1. Moreover, myostatin mRNA expression tended to increase, whereas mRNA levels of the myostatin inhibitor FSTL3 tended to decrease, in response to spaceflight. In addition, mRNA levels of the slow oxidative fiber-associated transcriptional coactivator peroxisome proliferator-associated receptor (PPAR)-γ coactivator-1α and the transcription factor PPAR-α were significantly decreased in spaceflight gastrocnemius. Finally, spaceflight resulted in a significant decrease in levels of the microRNA miR-206. Together these data demonstrate that spaceflight induces significant changes in mRNA expression of genes associated with muscle growth and fiber type. PMID:19074574

Physiological and Functional Alterations after Spaceflight and Bed Rest.

PubMed

Mulavara, Ajitkumar P; Peters, Brian T; Miller, Chris A; Kofman, Igor S; Reschke, Millard F; Taylor, Laura C; Lawrence, Emily L; Wood, Scott J; Laurie, Steven S; Lee, Stuart M C; Buxton, Roxanne E; May-Phillips, Tiffany R; Stenger, Michael B; Ploutz-Snyder, Lori L; Ryder, Jeffrey W; Feiveson, Alan H; Bloomberg, Jacob J

2018-04-03

Exposure to microgravity causes alterations in multiple physiological systems, potentially impacting the ability of astronauts to perform critical mission tasks. The goal of this study was to determine the effects of spaceflight on functional task performance and to identify the key physiological factors contributing to their deficits. A test battery comprised of 7 functional tests and 15 physiological measures was used to investigate the sensorimotor, cardiovascular and neuromuscular adaptations to spaceflight. Astronauts were tested before and after 6-month spaceflights. Subjects were also tested before and after 70 days of 6° head-down bed rest, a spaceflight analog, to examine the role of axial body unloading on the spaceflight results. These subjects included Control and Exercise groups to examine the effects of exercise during bed rest. Spaceflight subjects showed the greatest decrement in performance during functional tasks that required the greatest demand for dynamic control of postural equilibrium which was paralleled by similar decrements in sensorimotor tests that assessed postural and dynamic gait control. Other changes included reduced lower limb muscle performance and increased heart rate to maintain blood pressure. Exercise performed during bed rest prevented detrimental change in neuromuscular and cardiovascular function, however, both bed rest groups experienced functional and balance deficits similar to spaceflight subjects. Bed rest data indicates that body support unloading experienced during spaceflight contributes to postflight postural control dysfunction. Further, the bed rest results in the Exercise group of subjects confirm that resistance and aerobic exercises performed during spaceflight can play an integral role in maintaining neuromuscular and cardiovascular function, which can help in reducing decrements in functional performance. These results indicate that a countermeasure to mitigate postflight postural control dysfunction is required to maintain functional performance.

NASA Human Spaceflight Conjunction Assessment: Recent Conjunctions of Interest

NASA Technical Reports Server (NTRS)

Browns, Ansley C.

2010-01-01

This viewgraph presentation discusses a brief history of NASA Human Spaceflight Conjunction Assessment (CA) activities, an overview of NASA CA process for ISS and Shuttle, and recent examples from Human Spaceflight conjunctions.

Transgene expression patterns indicate that spaceflight affects stress signal perception and transduction in arabidopsis.

PubMed

Paul, A L; Daugherty, C J; Bihn, E A; Chapman, D K; Norwood, K L; Ferl, R J

2001-06-01

The use of plants as integral components of life support systems remains a cornerstone of strategies for long-term human habitation of space and extraterrestrial colonization. Spaceflight experiments over the past few decades have refined the hardware required to grow plants in low-earth orbit and have illuminated fundamental issues regarding spaceflight effects on plant growth and development. Potential incipient hypoxia, resulting from the lack of convection-driven gas movement, has emerged as a possible major impact of microgravity. We developed transgenic Arabidopsis containing the alcohol dehydrogenase (Adh) gene promoter linked to the beta-glucuronidase (GUS) reporter gene to address specifically the possibility that spaceflight induces the plant hypoxia response and to assess whether any spaceflight response was similar to control terrestrial hypoxia-induced gene expression patterns. The staining patterns resulting from a 5-d mission on the orbiter Columbia during mission STS-93 indicate that the Adh/GUS reporter gene was activated in roots during the flight. However, the patterns of expression were not identical to terrestrial control inductions. Moreover, although terrestrial hypoxia induces Adh/GUS expression in the shoot apex, no apex staining was observed in the spaceflight plants. This indicates that either the normal hypoxia response signaling is impaired in spaceflight or that spaceflight inappropriately induces Adh/GUS activity for reasons other than hypoxia.