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Sample records for mart jakobson argo

  1. Roman Jakobson's Semiotic Theory of Communication. [Revised.

    ERIC Educational Resources Information Center

    Lanigan, Richard L.

    For most of the 20th century, Roman Jakobson's name will have been synonymous with the definition of communication as a human science, i.e., communicology. Jakobson is the modern source of most of what communication scholars theorize about and practice as human communication, and he will be the source of how communication scholars shall come to…

  2. Argo Navis

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    (the Ship) a large southern constellation representing the ship Argo of Jason and the Argonauts in Greek mythology whose brightest stars were cataloged by Ptolemy (c. AD 100-175) in the Almagest. It was divided up by the French astronomer Nicolas L de Lacaille (1713-62), who charted the southern sky in 1751-2, into the constellations Carina (the Keel), Vela (the Sails), Puppis (the Poop or Stern)...

  3. Marte Vallis

    NASA Technical Reports Server (NTRS)

    2005-01-01

    16 December 2005 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows the results of catastrophic flooding in Marte Vallis, Mars. Marte is the Spanish word for Mars. Many of the major valleys on the red planet are named for the word for 'Mars' in the various languages of Earth. This image shows just a very small portion of the hundreds-of-kilometers-long Marte Vallis system.

    Location near: 17.4oN, 174.7o Image width: width: 3 km (1.9 mi) Illumination from: lower left Season: Northern Winter

  4. Marte Vallis

    NASA Technical Reports Server (NTRS)

    2005-01-01

    16 December 2005 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows the results of catastrophic flooding in Marte Vallis, Mars. Marte is the Spanish word for Mars. Many of the major valleys on the red planet are named for the word for 'Mars' in the various languages of Earth. This image shows just a very small portion of the hundreds-of-kilometers-long Marte Vallis system.

    Location near: 17.4oN, 174.7o Image width: width: 3 km (1.9 mi) Illumination from: lower left Season: Northern Winter

  5. Argo Development Program.

    DTIC Science & Technology

    1986-06-01

    Reference 8). 3. NR-1 Operations on the Reykjanes Ridge (Modification P00005): .’ l In August 1984 an investigation of the axial processes of the Reykjanes ...This system concept grew out of the ARGO imaging research funded by this contract. Results of the scientific exploration of the Reykjanes Ridge were... Ridge was conducted using the NR-1. The NR-1 was outfitted with a special low light level TV system with funding from Naval Sea Systems Command, PMS-395

  6. The ARGO Project

    NASA Astrophysics Data System (ADS)

    Kozameh, C. N.

    El proyecto µARGO propone el desarrollo, construcción y operación del Observatorio Espacial de Rayos Gamma, que operará en una órbita terrestre. Este observatorio constará de un telescopio con capacidad de medir simultáneamente dirección de incidencia y polarización de rayos Gamma en dos rangos de energía: 50 KeV - 3 MeV y 10 MeV - 1 GeV. Para ello se usarán detectores de silicio de última generación y microelectrónica adaptada a la configuración. La masa total en órbita del observatorio estará en el orden de los 60 - 100 kg. dependiendo de la geometría adoptada lo que permitirá minimizar costos de desarrollo y construcción, sin perder por ello calidad en su misión científica. ? Desde el punto de vista energético μARGO cubrirá el rango cubierto por COMPTEL y EGRET del CGRO, duplicando como mínimo la resolución angular de ambos con una reducción de peso de dos órdenes de magnitud. En adición, μARGO podr´ medir la polarización incidente de los rayos energéticos. Si bien existen otros dos proyectos en marcha (GLAST y AGILE) para reemplazar EGRET que serán lanzados antes que μARGO, estos proyectos no están diseñados para medir polarización ni tampoco cubren el rango mas bajo de energía arriba mencionado.

  7. Communicative Competence vs. Communicative Cognizance: Jakobson's Model Revisited.

    ERIC Educational Resources Information Center

    Brown, James W.

    1984-01-01

    Jakobson's communication model, grounded in semiotic theory, provides an excellent point of departure for developing specific pedagogical approaches to the constituent elements of all communicative acts, verbal or nonverbal. True communication occurs only when students and teachers are cognizant of the features and functions of communication as…

  8. Systemwide Power Management with Argo

    SciTech Connect

    Ellsworth, Daniel; Patki, Tapasya; Perarnau, Swann; Seo, Sangmin; Yoshii, Kazutomo; Hoffmann, Henry; Schulz, Martin; Beckman, Pete

    2016-05-23

    The Argo project is a DOE initiative for designing a modular operating system/runtime for the next generation of supercomputers. A key focus area in this project is power management, which is one of the main challenges on the path to exascale. In this paper, we discuss ideas for systemwide power management in the Argo project. We present a hierarchical and scalable approach to maintain a power bound at scale, and we highlight some early results.

  9. Status of the ARGOS project

    NASA Astrophysics Data System (ADS)

    Rabien, Sebastian; Barl, Lothar; Beckmann, Udo; Bonaglia, Marco; Borelli, José Luis; Brynnel, Joar; Buschkamp, Peter; Busoni, Lorenzo; Christou, Julian; Connot, Claus; Davies, Richard; Deysenroth, Matthias; Esposito, Simone; Gässler, Wolfgang; Gemperlein, Hans; Hart, Michael; Kulas, Martin; Lefebvre, Michael; Lehmitz, Michael; Mazzoni, Tommaso; Nussbaum, Edmund; Orban de Xivry, Gilles; Peter, Diethard; Quirrenbach, Andreas; Raab, Walfried; Rahmer, Gustavo; Storm, Jesper; Ziegleder, Julian

    2014-07-01

    ARGOS is the Laser Guide Star and Wavefront sensing facility for the Large Binocular Telescope. With first laser light on sky in 2013, the system is currently undergoing commissioning at the telescope. We present the overall status and design, as well as first results on sky. Aiming for a wide field ground layer correction, ARGOS is designed as a multi- Rayleigh beacon adaptive optics system. A total of six powerful pulsed lasers are creating the laser guide stars in constellations above each of the LBTs primary mirrors. With a range gated detection in the wavefront sensors, and the adaptive correction by the deformable secondary's, we expect ARGOS to enhance the image quality over a large range of seeing conditions. With the two wide field imaging and spectroscopic instruments LUCI1 and LUCI2 as receivers, a wide range of scientific programs will benefit from ARGOS. With an increased resolution, higher encircled energy, both imaging and MOS spectroscopy will be boosted in signal to noise by a large amount. Apart from the wide field correction ARGOS delivers in its ground layer mode, we already foresee the implementation of a hybrid Sodium with Rayleigh beacon combination for a diffraction limited AO performance.

  10. Animal Tracking ARGOS vs GPS

    NASA Astrophysics Data System (ADS)

    Robinson, P. W.; Costa, D.; Arnould, J.; Weise, M.; Kuhn, C.; Simmons, S. E.; Villegas, S.; Tremblay, Y.

    2006-12-01

    ARGOS satellite tracking technology has enabled a tremendous increase in our understanding of the movement patterns of a diverse array of marine vertebrates from Sharks to marine mammals. Our current understanding has moved from simple descriptions of large scale migratory patterns to much more sophisticated comparisons of animal movements and behavior relative to oceanic features. Further, animals are increasingly used to carry sensors that can acquire water column temperature and salinity profiles. However, a major limitation of this work is the spatial precision of ARGOS locations. ARGOS provides 7 location qualities that range from 3,2,1,0,A,B,Z and correspond to locations with a precision of 150m to tens of kilometers. Until recently, GPS technology could not be effectively used with marine mammals because they did not spend sufficient time at the surface to allow complete acquisition of satellite information. The recent development of Fastloc technology has allowed the development of GPS tags that can be deployed on marine mammals. Here we compare the location quality and frequency derived from standard ARGOS PTTs to Fastloc GPS locations acquired from 11 northern elephant seals, 5 California and 5 Galapagos sea lions and 1 Cape and 3 Australian fur seals. Our results indicate that GPS technology will greatly enhance our ability to understand the movement patterns of marine vertebrates and the in-situ oceanographic data they collect.

  11. ARGOS wavefront sensing: from detection to correction

    NASA Astrophysics Data System (ADS)

    Orban de Xivry, Gilles; Bonaglia, M.; Borelli, J.; Busoni, L.; Connot, C.; Esposito, S.; Gaessler, W.; Kulas, M.; Mazzoni, T.; Puglisi, A.; Rabien, S.; Storm, J.; Ziegleder, J.

    2014-08-01

    Argos is the ground-layer adaptive optics system for the Large Binocular Telescope. In order to perform its wide-field correction, Argos uses three laser guide stars which sample the atmospheric turbulence. To perform the correction, Argos has at disposal three different wavefront sensing measurements : its three laser guide stars, a NGS tip-tilt, and a third wavefront sensor. We present the wavefront sensing architecture and its individual components, in particular: the finalized Argos pnCCD camera detecting the 3 laser guide stars at 1kHz, high quantum efficiency and 4e- noise; the Argos tip-tilt sensor based on a quad-cell avalanche photo-diodes; and the Argos wavefront computer. Being in the middle of the commissioning, we present the first wavefront sensing configurations and operations performed at LBT, and discuss further improvements in the measurements of the 3 laser guide star slopes as detected by the pnCCD.

  12. Computational analysis of EGFR inhibition by Argos.

    PubMed

    Reeves, Gregory T; Kalifa, Rachel; Klein, Daryl E; Lemmon, Mark A; Shvartsman, Stanislav Y

    2005-08-15

    Argos, a secreted inhibitor of the Drosophila epidermal growth factor receptor, and the only known secreted receptor tyrosine kinase inhibitor, acts by sequestering the EGFR ligand Spitz. We use computational modeling to show that this biochemically-determined mechanism of Argos action can explain available genetic data for EGFR/Spitz/Argos interactions in vivo. We find that efficient Spitz sequestration by Argos is key for explaining the existing data and for providing a robust feedback loop that modulates the Spitz gradient in embryonic ventral ectoderm patterning. Computational analysis of the EGFR/Spitz/Argos module in the ventral ectoderm shows that Argos need not be long-ranged to account for genetic data, and can actually have very short range. In our models, Argos with long or short length scale functions to limit the range and action of secreted Spitz. Thus, the spatial range of Argos does not have to be tightly regulated or may act at different ranges in distinct developmental contexts.

  13. Euro-Argo: The European contribution to the global Argo ocean observations network

    NASA Astrophysics Data System (ADS)

    Gourcuff, Claire

    2017-04-01

    The international Argo programme is a major element of the global in-situ ocean observing system. More than 3900 floats are now globally measuring temperature and salinity throughout the global oceans, down to 2,000 meters depth and delivering data both in real time for operational users and after careful scientific quality control for climate change research and monitoring. Argo is the single most important in-situ observing system for the Copernicus Marine Service. The Euro-Argo research infrastructure organizes and federates European contribution to Argo. A legal and governance framework (Euro-Argo ERIC) was set up in May 2014; it allows European countries to consolidate and improve their contribution to Argo international. We will provide an overview of the development of Euro-Argo over the past years and present the now agreed Euro-Argo long term organization. The capability of the Euro-Argo infrastructure to organize Argo floats procurement, deployment and processing at European level and to conduct R&D driven by Copernicus needs will be highlighted. During the recent years, within the H2020 E-AIMS project, Euro-Argo carried R&D activities on new Argo floats, equipped with biogeochemical sensors or able to dive up to 4000m, from the floats design up to the analysis of their measurements. European Argo data centers were adapted so that they can handle the new data. Observing System Evaluations and Simulation Experiments were also conducted to provide robust recommendations for the next phase of Argo. One of the main challenges for Euro-Argo is now to implement the next phase of Argo with an extension towards biogeochemistry (e.g. oxygen, biology), the polar oceans, the marginal seas and the deep ocean. Meeting such challenges is essential for the long term sustainability and evolution of the Copernicus Marine Service. We will present Euro-Argo strategy and provide some highlights on the implementation-plan for the years to come and the Argo extensions for the

  14. P-Mart

    SciTech Connect

    2016-10-07

    P-Mart was designed specifically to allow cancer researchers to perform robust statistical processing of publicly available cancer proteomic datasets. To date an online statistical processing suite for proteomics does not exist. The P-Mart software is designed to allow statistical programmers to utilize these algorithms through packages in the R programming language as well as offering a web-based interface using the Azure cloud technology. The Azure cloud technology also allows the release of the software via Docker containers.

  15. Results from ARGO-YBJ

    SciTech Connect

    Iacovacci, M.

    2009-04-08

    The ARGO-YBJ experiment has been put in stable data taking at the YangBaJing Cosmic Ray Laboratory (Tibet, P.R. China, 4300 m a.s.l.). In this paper we report a few selected results in Gamma-Ray Astronomy (Crab Nebula and Mrk421 observations, search for high energy tails of Gamma Ray Bursts) and Cosmic Ray Physics (Moon and Sun shadow observations, proton-air cross section measurement, preliminary measurement of the antiproton/proton ratio at TeV energies)

  16. Results from ARGO-YBJ

    NASA Astrophysics Data System (ADS)

    Iacovacci, M.

    2009-04-01

    The ARGO-YBJ experiment has been put in stable data taking at the YangBaJing Cosmic Ray Laboratory (Tibet, P.R. China, 4300 m a.s.l.). In this paper we report a few selected results in Gamma-Ray Astronomy (Crab Nebula and Mrk421 observations, search for high energy tails of Gamma Ray Bursts) and Cosmic Ray Physics (Moon and Sun shadow observations, proton-air cross section measurement, preliminary measurement of the antiproton/proton ratio at TeV energies).

  17. ARGOS laser system mechanical design

    NASA Astrophysics Data System (ADS)

    Deysenroth, M.; Honsberg, M.; Gemperlein, H.; Ziegleder, J.; Raab, W.; Rabien, S.; Barl, L.; Gässler, W.; Borelli, J. L.

    2014-07-01

    ARGOS, a multi-star adaptive optics system is designed for the wide-field imager and multi-object spectrograph LUCI on the LBT (Large Binocular Telescope). Based on Rayleigh scattering the laser constellation images 3 artificial stars (at 532 nm) per each of the 2 eyes of the LBT, focused at a height of 12 km (Ground Layer Adaptive Optics). The stars are nominally positioned on a circle 2' in radius, but each star can be moved by up to 0.5' in any direction. For all of these needs are following main subsystems necessary: 1. A laser system with its 3 Lasers (Nd:YAG ~18W each) for delivering strong collimated light as for LGS indispensable. 2. The Launch system to project 3 beams per main mirror as a 40 cm telescope to the sky. 3. The Wave Front Sensor with a dichroic mirror. 4. The dichroic mirror unit to grab and interpret the data. 5. A Calibration Unit to adjust the system independently also during day time. 6. Racks + platforms for the WFS units. 7. Platforms and ladders for a secure access. This paper should mainly demonstrate how the ARGOS Laser System is configured and designed to support all other systems.

  18. Psychopathology and the essence of language: the interpretation of aphasia by Kurt Goldstein and Roman Jakobson.

    PubMed

    Friedrich, Janette

    2006-12-01

    This paper presents a comparative analysis of the research on aphasia carried out by the linguist Roman Jakobson and the neuropsychiatrist Kurt Goldstein. The linguistic theory of aphasia advocated by Jakobson in the 1950s and 1960s is based on clinical case studies reported by Goldstein at the beginning of the 1930s. However, Jakobson used Goldstein's clinical observations without taking into account his theoretical work on language pathology. In particular, Jakobson fed the symptoms described by Goldstein into a structuralist model, allowing him to predict different types of aphasia deductively. Goldstein, however, saw the clinical manifestations of aphasia as a particular way of being in the world. By studying the changes associated with the patient's reaction to the disease, Goldstein wanted to reach an understanding of language functioning in the normal subject. He distinguished between an instrumental use and a symbolic use of language, the latter mainly characteristic of language use in the normal subject. Only a symbolic use reveals the essence of language by showing its intimate nature, the psychic link tying the subject to the world.

  19. Marte Valles site

    NASA Technical Reports Server (NTRS)

    Rice, Jim W.

    1994-01-01

    This site is located at 16 deg N, 177 deg W on the flood plains of Marte Valles, which is perhaps the youngest channel system on Mars. The young age of this channel warrants investigation because of climatic implications for fluvial activities in recent geologic time. The paucity of craters makes this an excellent site in terms of safety requirements. Some of the objectives stated previously for the Maja Valles region would also apply to this site (grab bag of rock types, etc.).

  20. Complete mitochondrial genome of European pine marten, Martes martes.

    PubMed

    Li, Bo; Wu, Dan; Malyarchuk, Boris

    2014-10-01

    Abstract We undertook the first sequencing of the entire mitogenome of Martes martes. The genome is 16,486 bp in length and contains 13 protein-coding genes, 22 tRNA genes, two rRNA genes and a control region. The total base composition of the mitogenome is 31.9% for A, 27. 6% for C, 25.8% for T and 14.7% for G. The genome organization, nucleotide composition and codon usage do not differ significantly from other martens. This mitogenome sequence data might be useful for phylogenetic and systematic analyses within the genus Martes.

  1. Marte Vallis Platy Flows

    NASA Technical Reports Server (NTRS)

    2003-01-01

    MGS MOC Release No. MOC2-442, 4 August 2003

    The Marte Vallis system, located east of Cerberus and west of Amazonis Planitia, is known for its array of broken, platy flow features. This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows a close-up view of some of these plates; they appear to be like puzzle pieces that have been broken apart and moved away from each other. The Mars science community has been discussing these features for the past several years--either the flows in Marte Vallis are lava flows, or mud flows. In either case, the material was very fluid and had a thin crust on its surface. As the material continued to flow through the valley system, the crust broke up into smaller plates that were then rafted some distance down the valley. This picture is located near 6.9oN, 182.8oW. It is illuminated by sunlight from the left.

  2. [Estradiol inducible and flower-specific expression of ARGOS and ARGOS-LIKE genes in transgenic tobacco plants].

    PubMed

    Kuluev, B R; Kniazev, A V; Nikonorov, Iu M; Cheremis, A V

    2014-08-01

    Transgenic tobacco plants expressing Arabidopsis thaliana ARGOS and ARGOS-LIKE genes under the control of the chalcone synthase promoter of Petunia hybrid L., as well as the estradiol inducible XVE system, have been obtained. The part of transgenic plants with flower-specific expression of the target genes was characterized by increased flower size, caused by an increase in cell size and quantity in the case of the ARGOS gene and by a stimulation of cell growth via stretching in the case of the ARGOS-LIKE gene. An enhanced expression level of the NtEXPA1, NtEXPA4 genes encoding expansins, NtEXGT gene encoding endo-xyloglucan transferase, and the AINTEGUMENTA-like gene was detected in the flowers of transgenic tobacco plants. In the case of inducible expression of ARGOS and ARGOS-LIKE genes, an increase in leaf, stem and flower size was revealed in several lines of transgenic plants as compared to control. Expression of the ARGOS gene also affected cell number and size in this case, while the ARGOS-LIKE gene mainly influenced cell size via stretching. Inducible expression of the ARGOS gene in flowers mainly provided an enhanced containment of AINTEGUMENTA-like mRNA, while ARGOS-LIKE gene expression resulted in the activation of NtEXPA1 and NtEXGT genes.

  3. The ArgoNeuT Experiment

    SciTech Connect

    Szelc, Andrzej M.

    2015-05-15

    The ArgoNeuT (Argon Neutrino Test) Experiment ran on the NuMI beam line at the Fermi National Accelerator Laboratory, from Sep 2009 to Feb 2010. It is the first stage of the US R and D effort on using Liquid Argon Time Projection Chambers (LArTPCs) as neutrino detectors. ArgoNeuT has collected thousands of beam neutrino events in the 0.1 -10 GeV energy range during its run and, apart from fulfilling its R and D goals, is now publishing physics results, including the first measurement of the inclusive muon neutrino charged current differential cross sections on argon. These proceedings will present these results, together with the perspectives for ongoing and future analyses, as well as ideas for running the detector in a test beam of charged particles.

  4. Structural basis for EGFR ligand sequestration by Argos

    SciTech Connect

    Klein, Daryl E.; Stayrook, Steven E.; Shi, Fumin; Narayan, Kartik; Lemmon, Mark A.

    2008-06-26

    Members of the epidermal growth factor receptor (EGFR) or ErbB/HER family and their activating ligands are essential regulators of diverse developmental processes. Inappropriate activation of these receptors is a key feature of many human cancers, and its reversal is an important clinical goal. A natural secreted antagonist of EGFR signalling, called Argos, was identified in Drosophila. We showed previously that Argos functions by directly binding (and sequestering) growth factor ligands that activate EGFR5. Here we describe the 1.6-{angstrom} resolution crystal structure of Argos bound to an EGFR ligand. Contrary to expectations, Argos contains no EGF-like domain. Instead, a trio of closely related domains (resembling a three-finger toxin fold) form a clamp-like structure around the bound EGF ligand. Although structurally unrelated to the receptor, Argos mimics EGFR by using a bipartite binding surface to entrap EGF. The individual Argos domains share unexpected structural similarities with the extracellular ligand-binding regions of transforming growth factor-{beta} family receptors. The three-domain clamp of Argos also resembles the urokinase-type plasminogen activator (uPA) receptor, which uses a similar mechanism to engulf the EGF-like module of uPA. Our results indicate that undiscovered mammalian counterparts of Argos may exist among other poorly characterized structural homologues. In addition, the structures presented here define requirements for the design of artificial EGF-sequestering proteins that would be valuable anti-cancer therapeutics.

  5. Structural basis for EGFR ligand sequestration by Argos.

    PubMed

    Klein, Daryl E; Stayrook, Steven E; Shi, Fumin; Narayan, Kartik; Lemmon, Mark A

    2008-06-26

    Members of the epidermal growth factor receptor (EGFR) or ErbB/HER family and their activating ligands are essential regulators of diverse developmental processes. Inappropriate activation of these receptors is a key feature of many human cancers, and its reversal is an important clinical goal. A natural secreted antagonist of EGFR signalling, called Argos, was identified in Drosophila. We showed previously that Argos functions by directly binding (and sequestering) growth factor ligands that activate EGFR. Here we describe the 1.6-A resolution crystal structure of Argos bound to an EGFR ligand. Contrary to expectations, Argos contains no EGF-like domain. Instead, a trio of closely related domains (resembling a three-finger toxin fold) form a clamp-like structure around the bound EGF ligand. Although structurally unrelated to the receptor, Argos mimics EGFR by using a bipartite binding surface to entrap EGF. The individual Argos domains share unexpected structural similarities with the extracellular ligand-binding regions of transforming growth factor-beta family receptors. The three-domain clamp of Argos also resembles the urokinase-type plasminogen activator (uPA) receptor, which uses a similar mechanism to engulf the EGF-like module of uPA. Our results indicate that undiscovered mammalian counterparts of Argos may exist among other poorly characterized structural homologues. In addition, the structures presented here define requirements for the design of artificial EGF-sequestering proteins that would be valuable anti-cancer therapeutics.

  6. Informing Deep Argo Array Design Using Argo and Full-Depth Hydrographic Section Data

    NASA Astrophysics Data System (ADS)

    Johnson, G. C.; Lyman, J. M.; Purkey, S.

    2016-02-01

    Data from full-depth closely sampled hydrographic sections and Argo floats are analyzed to inform the design of a future Deep Argo array. Here standard errors of local decadal temperature trends and global decadal trends of ocean heat content and thermosteric sea level anomalies integrated from 2000-6000 dbar are estimated for a hypothetical 5º lat. x 5º long. x 15-day cycle Deep Argo array. These estimates are made using temperature variances from closely spaced, full-depth CTD profiles taken during hydrographic sections. The temperature data along each section are high-passed laterally at a 500-km scale, and the resulting variances averaged in 5º x 5º bins to assess temperature noise levels as a function of pressure and geographic location. A mean global de-correlation time scale of 62 days is estimated using temperature time series at 1800 dbar from Argo floats. The hypothetical Deep Argo array would be capable of resolving, at one standard error, local trends from < 1 mºC decade-1 in the quiescent abyssal North Pacific to about 26 mºC decade-1 below 2000 dbar along 50ºS in the energetic Southern Ocean. Larger decadal temperature trends have been reported previously in these regions using repeat hydrographic section data, but those very sparse data required substantial spatial averaging to obtain statistically significant results. Furthermore, the array would provide decadal global ocean heat content trend estimates from 2000-6000 dbar with a standard error of ±3 TW, compared to a trend standard error of ±17 TW from a previous analysis of repeat hydrographic data.

  7. Highlights from the ARGO-YBJ experiment

    NASA Astrophysics Data System (ADS)

    Aielli, G.; Bacci, C.; Bartoli, B.; Bernardini, P.; Bi, X. J.; Bleve, C.; Branchini, P.; Budano, A.; Bussino, S.; Calabrese Melcarne, A. K.; Camarri, P.; Cao, Z.; Cappa, A.; Cardarelli, R.; Catalanotti, S.; Cattaneo, C.; Celio, P.; Chen, S. Z.; Chen, T. L.; Chen, Y.; Cheng, N.; Creti, P.; Cui, S. W.; Dai, B. Z.; D'Alí Staiti, G.; Danzengluobu; Dattoli, M.; de Mitri, I.; D'Ettorre Piazzoli, B.; de Vincenzi, M.; di Girolamo, T.; Ding, X. H.; di Sciascio, G.; Feng, C. F.; Feng, Zhaoyang; Feng, Zhenyong; Galeazzi, F.; Galeotti, P.; Gargana, R.; Gou, Q. B.; Guo, Y. Q.; He, H. H.; Hu, Haibing; Hu, Hongbo; Huang, Q.; Iacovacci, M.; Iuppa, R.; James, I.; Jia, H. Y.; Labaciren; Li, H. J.; Li, J. Y.; Li, X. X.; Liberti, B.; Liguori, G.; Liu, C.; Liu, C. Q.; Liu, M. Y.; Liu, J.; Lu, H.; Ma, X. H.; Mancarella, G.; Mari, S. M.; Marsella, G.; Martello, D.; Mastroianni, S.; Meng, X. R.; Montini, P.; Ning, C. C.; Pagliaro, A.; Panareo, M.; Perrone, L.; Pistilli, P.; Qu, X. B.; Rossi, E.; Ruggieri, F.; Saggese, L.; Salvini, P.; Santonico, R.; Shen, P. R.; Sheng, X. D.; Shi, F.; Stanescu, C.; Surdo, A.; Tan, Y. H.; Vallania, P.; Vernetto, S.; Vigorito, C.; Wang, B.; Wang, H.; Wu, C. Y.; Wu, H. R.; Xu, B.; Xue, L.; Yan, Y. X.; Yang, Q. Y.; Yang, X. C.; Yuan, A. F.; Zha, M.; Zhang, H. M.; Zhang, Jilong; Zhang, Jianli; Zhang, L.; Zhang, P.; Zhang, X. Y.; Zhang, Y.; Zhaxisangzhu; Zhou, X. X.; Zhu, F. R.; Zhu, Q. Q.; Zizzi, G.

    2012-01-01

    The ARGO-YBJ experiment at YangBaJing in Tibet (4300 m a.s.l.) has been taking data with its full layout since October 2007. Here we present a few significant results obtained in gamma-ray astronomy and cosmic-ray physics. Emphasis is placed on the analysis of gamma-ray emission from point-like sources (Crab Nebula, MRK 421), on the preliminary limit on the antiproton/proton flux ratio, on the large-scale cosmic-ray anisotropy and on the proton-air cross-section. The performance of the detector is also discussed, and the perspectives of the experiment are outlined.

  8. The Argos seismic data message system.

    USGS Publications Warehouse

    Derr, J.S.; Hunter, R.N.

    1988-01-01

    A reliable, inexpensive method for sending limited daily seismic data messages from remote observatories to the National Earthquake Information Center has been developed for use with the Argos satellite system. Data messages are compressed on a microcomputer and passed automatically to a simple transmitter. About 4 hr later, the data are available at the National Earthquake Information Center, where they are decompressed and reformatted into standard telegrams for use in quick epicenter determinations. Epicenter data are available daily to the international scientific community.-Authors

  9. Recent highlights from ARGO-YBJ

    NASA Astrophysics Data System (ADS)

    Di Sciascio, Di; ARGO-YBJ Collaboration

    2016-05-01

    The ARGO-YBJ experiment has been in stable data taking for more than 5 years at the YangBaJing Cosmic Ray Laboratory (Tibet, P.R. China, 4300 m a.s.L, 606 g/cm2 ). With a duty-cycle of about 87% the detector collected more than 5×1011 events in a wide energy range, from few hundreds GeV up to 10 PeV. A number of open problems in cosmic ray physics has been faced exploiting different analyses. In this talk we summarize the latest physics results obtained in gamma-ray astronomy and in cosmic ray physics.

  10. Argos inhibits epidermal growth factor receptor signalling by ligand sequestration.

    PubMed

    Klein, Daryl E; Nappi, Valerie M; Reeves, Gregory T; Shvartsman, Stanislav Y; Lemmon, Mark A

    2004-08-26

    The epidermal growth factor receptor (EGFR) has critical functions in development and in many human cancers. During development, the spatial extent of EGFR signalling is regulated by feedback loops comprising both well-understood activators and less well-characterized inhibitors. In Drosophila melanogaster the secreted protein Argos functions as the only known extracellular inhibitor of EGFR, with clearly identified roles in multiple stages of development. Argos is only expressed when the Drosophila EGFR (DER) is activated at high levels, and downregulates further DER signalling. Although there is ample genetic evidence that Argos inhibits DER activation, the biochemical mechanism has not been established. Here we show that Argos inhibits DER signalling without interacting directly with the receptor, but instead by sequestering the DER-activating ligand Spitz. Argos binds tightly to the EGF motif of Spitz and forms a 1:1 (Spitz:Argos) complex that does not bind DER in vitro or at the cell surface. Our results provide an insight into the mechanism of Argos function, and suggest new strategies for EGFR inhibitor design.

  11. Experience of the ARGO autonomous vehicle

    NASA Astrophysics Data System (ADS)

    Bertozzi, Massimo; Broggi, Alberto; Conte, Gianni; Fascioli, Alessandra

    1998-07-01

    This paper presents and discusses the first results obtained by the GOLD (Generic Obstacle and Lane Detection) system as an automatic driver of ARGO. ARGO is a Lancia Thema passenger car equipped with a vision-based system that allows to extract road and environmental information from the acquired scene. By means of stereo vision, obstacles on the road are detected and localized, while the processing of a single monocular image allows to extract the road geometry in front of the vehicle. The generality of the underlying approach allows to detect generic obstacles (without constraints on shape, color, or symmetry) and to detect lane markings even in dark and in strong shadow conditions. The hardware system consists of a PC Pentium 200 Mhz with MMX technology and a frame-grabber board able to acquire 3 b/w images simultaneously; the result of the processing (position of obstacles and geometry of the road) is used to drive an actuator on the steering wheel, while debug information are presented to the user on an on-board monitor and a led-based control panel.

  12. First measurements with Argo flots in the Southern Baltic Sea

    NASA Astrophysics Data System (ADS)

    Walczowski, Waldemar; Goszczko, Ilona; Wieczorek, Piotr; Merchel, Malgorzata; Rak, Daniel

    2017-04-01

    The Argo programme is one of the most important elements of the ocean observing system. Currently almost 4000 Argo floats profile global oceans and deliver real time data. Originally Argo floats were developed for open ocean observations. Therefore a standard float can dive up to 2000 m and deep Argo floats are under development. However in the last years the shallow shelf seas become also interesting for Argo users. Institute of Oceanology Polish Academy of Sciences (IOPAN) participates in the Euro-Argo research infrastructure, the European contribution to Argo system. A legal and governance framework (Euro-Argo ERIC) was set up in May 2014. For a few years IOPAN has deployed floats mostly in the Nordic Seas and the European Arctic region. In the end of 2016 the first Polish Argo float was deployed in the Southern Baltic Sea. Building on the successful experience with Argo floats deployed by the Finnish oceanographers in the Bothnian Sea and Gotland Basin, the IOPAN float was launched in the Bornholm Deep during the fall cruise of IOPAN research vessel Oceania. The standard APEX float equipped with 2-way Iridium communication was used and different modes of operation, required for the specific conditions in the shallow and low saline Baltic Sea, were tested. Settings for the Baltic float are different than for the oceanic mode and were frequently changed during the mission to find the optimum solution. Changing the float parking depth during the mission allows for the limited control of the float drift direction. Results of a high resolution numerical forecast model for the Baltic Sea proved to be a valuable tool for determining the parking depth of the float in the different flow regimes. Trajectory and drift velocity of the Argo float deployed in the Southern Baltic depended strongly on the atmospheric forcing (in particular wind speed and direction), what was clearly manifested during the 'Axel' storm passing over the deployment area in January 2017. The first

  13. New developments in the global ocean observing system Argo and its European component EuroArgo

    NASA Astrophysics Data System (ADS)

    Klein, Birgit

    2017-04-01

    Since about 2005 Argo is the largest source of in situ ocean data, with the number of Argo-profiles exceeding that of all ship-born profiles ever made. Having a dense and near-homogeneous global and temporal coverage, Argo data are essential to derive ocean-state estimates to initialize seasonal and decadal climate model forecasts and to validate climate model output. For instance, Argo data made it possible to accurately determine ocean heat content and show that it kept increasing during the so-called hiatus period (2000-2014), during which atmospheric near-surface temperature stayed almost constant. Climate models ought to be able to reproduce such events. Currently Argo is entering new realms. New floats types are capable of measuring down to 4 km (instead of 2 km until now), and new sensors have been developed that can measure a variety of biogeochemical variables like oxygen, nitrate, or chlorophyll. These new data will be very important to validate and improve Earth System Models. First, about 40% of the ocean volume is in the depth-range 2-4 km, but observations are currently limited to a few sections in space and time. Deep Argo data will make a thorough validation of ocean models in this depth range possible for the first time. Secondly, the large amount of new biogeochemical data becoming available will allow process studies that will lead to improved parameterizations of biogenic and chemical processes in the ocean, improvements that can be implemented in the models to increase their realism. Third, the data form the first-ever set of biogeochemical data that is consistent and homogeneous over a large spatial and temporal extent will make it possible to validate the models to a degree that was hitherto impossible, simply because of the lack of data. The Argo data system is composed of national Data Assembly Centers (DAC) that supply data to two mirrored Global Data Assembly Centers (GDAC). GDAC data exchanges are based on File Transfer Protocol (FTP

  14. Development of a global gridded Argo data set with Barnes successive corrections

    NASA Astrophysics Data System (ADS)

    Li, Hong; Xu, Fanghua; Zhou, Wei; Wang, Dongxiao; Wright, Jonathon S.; Liu, Zenghong; Lin, Yanluan

    2017-02-01

    A new 11 year (2004-2014) monthly 1° gridded Argo temperature and salinity data set with 49 vertical levels from the surface to 1950 m depth (named BOA-Argo) is generated for use in ocean research and modeling studies. The data set is produced based on refined Barnes successive corrections by adopting flexible response functions based on a series of error analyses to minimize errors induced by nonuniform spatial distribution of Argo observations. These response functions allow BOA-Argo to capture a greater portion of mesoscale and large-scale signals while compressing small-sale and high-frequency noise relative to the most recent version of the World Ocean Atlas (WOA). BOA-Argo data set is evaluated against other gridded data sets, such as WOA13, Roemmich-Argo, Jamestec-Argo, EN4-Argo, and IPRC-Argo in terms of climatology, independent observations, mixed-layer depth, and so on. Generally, BOA-Argo compares well with other Argo gridded data sets. The RMSEs and correlation coefficients of compared variables from BOA-Argo agree most with those from the Roemmich-Argo. In particular, more mesoscale features are retained in BOA-Argo than others as compared to satellite sea surface heights. These results indicate that the BOA-Argo data set is a useful and promising adding to the current Argo data sets. The proposed refined Barnes method is computationally simple and efficient, so that the BOA-Argo data set can be easily updated to keep pace with tremendous daily increases in the volume of Argo temperature and salinity data.

  15. ARGOS - the Laser Star Adaptive Optics for LBT

    NASA Astrophysics Data System (ADS)

    Rabien, S.; Barl, L.; Beckmann, U.; Blümchen, T.; Bonaglia, M.; Borelli, J. L.; Brynnel, J.; Busoni, L.; Carbonaro, L.; Conot, C.; Davies, R.; Deysenroth, M.; Durney, O.; Elberich, M.; Esposito, S.; Gasho, V.; Gässler, W.; Gemperlein, H.; Genzel, R.; Green, R.; Haug, M.; Lloyd Hart, M.; Hubbard, P.; Kanneganti, S.; Kulas, M.; Noenickx, J.; Peter, D.; Quirrenbach, A.; Rademacher, M.; Rix, H. W.; Salinari, P.; Schwab, C.; Storm, J.; Strüder, L.; Thiel, M.; Weigelt, G.; Ziegleder, J.; de Xivry, G. Orban

    2011-09-01

    We will present the design and status of ARGOS - the Laser Guide Star adaptive optics facility for the Large Binocular Telescope. By projecting a constellation of multiple laser guide stars above each of the 8.4m primary mirrors of the LBT, ARGOS in its ground layer mode will enable a wide field adaptive optics correction for multi object spectroscopy. ARGOS implements high power pulsed green lasers and makes use of Rayleigh scattering for the guide star creation. The geometric relations of this setup in guide star height vs. primary diameter are quite comparable to an ELT with sodium guide stars. The use of LBT's adaptive secondary mirror, gated wavefront sensors, a prime focus calibration system and the laser constellation shows several aspects that may be used as pathfinding technology for the planned ELTs. In already planned upgrade steps with a hybrid Sodium-Rayleigh combination ARGOS will enable MCAO and MOAO implementations at LBT allowing unique astronomical observations.

  16. Finescale Water-Mass Variability from ARGO Profiling Floats

    DTIC Science & Technology

    2015-09-30

    1 DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. Finescale Water -Mass Variability from ARGO Profiling...assessment of water -mass (aka thermohaline or spice) variability as a measure of stirring along isopycnals, as well as density ratio Rρ statistics, from the...global ARGO profiling float data set. APPROACH For the water -mass analysis, the profile data is transformed onto σθ density coordinates

  17. ARGOS - II. The Galactic bulge survey

    NASA Astrophysics Data System (ADS)

    Freeman, K.; Ness, M.; Wylie-de-Boer, E.; Athanassoula, E.; Bland-Hawthorn, J.; Asplund, M.; Lewis, G.; Yong, D.; Lane, R.; Kiss, L.; Ibata, R.

    2013-02-01

    We describe the motivation, field locations and stellar selection for the Abundances and Radial velocity Galactic Origins Survey (ARGOS) spectroscopic survey of 28 000 stars in the bulge and inner disc of the Milky Way galaxy across latitudes of b = -5° to -10°. The primary goal of this survey is to constrain the formation processes of the bulge and establish whether it is predominantly a merger or instability remnant. From the spectra (R = 11 000), we have measured radial velocities and determined stellar parameters, including metallicities and [α/Fe] ratios. Distances were estimated from the derived stellar parameters and about 14 000 stars are red giants within 3.5 kpc of the Galactic Centre. In this paper, we present the observations and analysis methods. Subsequent papers (III and IV) will discuss the stellar metallicity distribution and kinematics of the Galactic bulge and inner disc, and the implications for the formation of the bulge.

  18. Prospects For a Carbon ARGO [ II

    NASA Astrophysics Data System (ADS)

    Bishop, J. K.

    2004-12-01

    Understanding the dynamics and sedimentation of biologically fixed particulate organic and inorganic carbon (POC and PIC) is fundamental to the prediction of future levels of atmospheric carbon dioxide. Over the last four years LBNL has been working to bridge a major 'space-time' gap in upper ocean carbon cycle observations. We have launched twelve robotic Carbon Explorers built on SIO's Orbcomm/GPS enhanced Sounding Oceanographic Lagrangian Observer (SOLO). These 'souped up' versions of ocean-profiling ARGO floats, operating in remote and stormy seas, have returned in real-time year-long high-frequency records of POC variability and recently have explored the systematics of carbon sedimentation to kilometer depths. We briefly recap the success of a new fast profiling optical sensor for PIC (sensitivity better than 0.1 μ M) which was deployed during routine CTD/rosette casts during the R/V Ron Brown June - July 2003 reoccupation of WOCE A16N (Iceland to Madiera) in the N Atlantic Ocean. Our primary aim is to report on the development of paired autonomous imaging sediment traps designed to optically record hourly variations of POC and PIC flux at depth for weeks to months. Preliminary analysis of 22 days of observations achieved this year near Hawaii indicate a major contribution of zooplankton parts to carbon flux at station ALOHA. We further recorded multiple events of simultaneous arrival of fecal material and associated zooplankton feeders. This supports the importance of such animals in determining the attenuation of carbon flux to the deep sea. The success of the Carbon Explorers, the new PIC sensor, and the developing capability for season to year-long high frequency records of POC and PIC carbon sedimentation in the very observation-poor but biologically-active upper kilometers of the ocean suggest excellent prospects for a 'Carbon-ARGO'.

  19. ARGO CMB Anisotropy Measurement Constraints on Open and Flat-A CDM Cosmogonies

    NASA Technical Reports Server (NTRS)

    Ratra, B.; Ganga, K.; Stompor, R.; Sugiyama, N.; de Bernardis, P.; Gorski, K. M.

    1998-01-01

    We use data from the ARGO cosmic microwave background (CMB) anisotropy experiment to constrain cosmogonies. We account for the ARGO beamwidth and calibration uncertainties, and marginalize over the offset removed from the data.

  20. Text-mining-assisted biocuration workflows in Argo

    PubMed Central

    Rak, Rafal; Batista-Navarro, Riza Theresa; Rowley, Andrew; Carter, Jacob; Ananiadou, Sophia

    2014-01-01

    Biocuration activities have been broadly categorized into the selection of relevant documents, the annotation of biological concepts of interest and identification of interactions between the concepts. Text mining has been shown to have a potential to significantly reduce the effort of biocurators in all the three activities, and various semi-automatic methodologies have been integrated into curation pipelines to support them. We investigate the suitability of Argo, a workbench for building text-mining solutions with the use of a rich graphical user interface, for the process of biocuration. Central to Argo are customizable workflows that users compose by arranging available elementary analytics to form task-specific processing units. A built-in manual annotation editor is the single most used biocuration tool of the workbench, as it allows users to create annotations directly in text, as well as modify or delete annotations created by automatic processing components. Apart from syntactic and semantic analytics, the ever-growing library of components includes several data readers and consumers that support well-established as well as emerging data interchange formats such as XMI, RDF and BioC, which facilitate the interoperability of Argo with other platforms or resources. To validate the suitability of Argo for curation activities, we participated in the BioCreative IV challenge whose purpose was to evaluate Web-based systems addressing user-defined biocuration tasks. Argo proved to have the edge over other systems in terms of flexibility of defining biocuration tasks. As expected, the versatility of the workbench inevitably lengthened the time the curators spent on learning the system before taking on the task, which may have affected the usability of Argo. The participation in the challenge gave us an opportunity to gather valuable feedback and identify areas of improvement, some of which have already been introduced. Database URL: http://argo.nactem.ac.uk PMID

  1. Text-mining-assisted biocuration workflows in Argo.

    PubMed

    Rak, Rafal; Batista-Navarro, Riza Theresa; Rowley, Andrew; Carter, Jacob; Ananiadou, Sophia

    2014-01-01

    Biocuration activities have been broadly categorized into the selection of relevant documents, the annotation of biological concepts of interest and identification of interactions between the concepts. Text mining has been shown to have a potential to significantly reduce the effort of biocurators in all the three activities, and various semi-automatic methodologies have been integrated into curation pipelines to support them. We investigate the suitability of Argo, a workbench for building text-mining solutions with the use of a rich graphical user interface, for the process of biocuration. Central to Argo are customizable workflows that users compose by arranging available elementary analytics to form task-specific processing units. A built-in manual annotation editor is the single most used biocuration tool of the workbench, as it allows users to create annotations directly in text, as well as modify or delete annotations created by automatic processing components. Apart from syntactic and semantic analytics, the ever-growing library of components includes several data readers and consumers that support well-established as well as emerging data interchange formats such as XMI, RDF and BioC, which facilitate the interoperability of Argo with other platforms or resources. To validate the suitability of Argo for curation activities, we participated in the BioCreative IV challenge whose purpose was to evaluate Web-based systems addressing user-defined biocuration tasks. Argo proved to have the edge over other systems in terms of flexibility of defining biocuration tasks. As expected, the versatility of the workbench inevitably lengthened the time the curators spent on learning the system before taking on the task, which may have affected the usability of Argo. The participation in the challenge gave us an opportunity to gather valuable feedback and identify areas of improvement, some of which have already been introduced. Database URL: http://argo.nactem.ac.uk.

  2. High-resolution Bio-Argo and Argo Measurements to Reveal Specific Oceanic Processes.

    NASA Astrophysics Data System (ADS)

    Poteau, A.; Claustre, H.; Briggs, N.; D'Ortenzio, F.; Schmechtig, C.; Prieur, L. M.; Boss, E.

    2016-02-01

    Together with temperature and salinity measurements, Bio-Argo profiling floats now measure a significant range of biogeochemical (e.g. O2, NO3) and bio-optical variables (Chla, backscattering coefficient and radiometry). To transmit the very large amount of data acquired by this new generation of floats, it was required to substitute the Argos telemetry (Argo program) with iridium telemetry. The obvious consequence is not only a much greater flexibly on data transmission but also on data acquisition thanks to the two-way communication allowed by iridium. Our group has now deployed and managed over 100 Bio-Argo floats of this type. In particular we have set up high-resolution mode of acquisition for certain periods of time or for dedicated portions of the water column. Here we illustrate with three examples the potential of conducting high-resolution measurement to identify and explore certain oceanic processes. (1) High resolution measurements of pressure, temperature and salinity (every 2 s) when the float is finishing its ascent (without any pump action) in the upper 10 m layer are analyzed with respect to sea state. We particularly focus on the study of the speed anomaly as compared to a nominal speed expected for a calm sea state. By comparison between speed anomaly of a float in the Mediterranean Sea and concurrent sea state measurements by a weather buoy in the same area, we suggest that float behaviour can be an indicator of sea state. (2) Each year, in response to springtime phytoplankton blooms, the resolution of bio-optical variables (backscattering and Chla) in the top 1000 m was increased to at least 1 m (every 10 s) for all floats in the North Atlantic and Southern Ocean. This resolution allowed accurate estimation of the concentration of large phytoplankton aggregates and revealed systematic differences in bulk aggregate sinking rate between ocean basins. (3) Finally we continuously record all the variables at a 10 min resolution during the float

  3. ARGOS policy brief on semantic interoperability.

    PubMed

    Kalra, Dipak; Musen, Mark; Smith, Barry; Ceusters, Werner; De Moor, Georges

    2011-01-01

    Semantic interoperability is one of the priority themes of the ARGOS Trans-Atlantic Observatory. This topic represents a globally recognised challenge that must be addressed if electronic health records are to be shared among heterogeneous systems, and the information in them exploited to the maximum benefit of patients, professionals, health services, research, and industry. Progress in this multi-faceted challenge has been piecemeal, and valuable lessons have been learned, and approaches discovered, in Europe and in the US that can be shared and combined. Experts from both continents have met at three ARGOS workshops during 2010 and 2011 to share understanding of these issues and how they might be tackled collectively from both sides of the Atlantic. This policy brief summarises the problems and the reasons why they are important to tackle, and also why they are so difficult. It outlines the major areas of semantic innovation that exist and that are available to help address this challenge. It proposes a series of next steps that need to be championed on both sides of the Atlantic if further progress is to be made in sharing and analysing electronic health records meaningfully. Semantic interoperability requires the use of standards, not only for EHR data to be transferred and structurally mapped into a receiving repository, but also for the clinical content of the EHR to be interpreted in conformity with the original meanings intended by its authors. Wide-scale engagement with professional bodies, globally, is needed to develop these clinical information standards. Accurate and complete clinical documentation, faithful to the patient's situation, and interoperability between systems, require widespread and dependable access to published and maintained collections of coherent and quality-assured semantic resources, including models such as archetypes and templates that would (1) provide clinical context, (2) be mapped to interoperability standards for EHR data

  4. Cotransfection of DC with TLR4 and MART-1 RNA induces MART-1-specific responses.

    PubMed

    Abdel-Wahab, Zeinab; Cisco, Robin; Dannull, Jens; Ueno, Tomio; Abdel-Wahab, Omar; Kalady, Matthew F; Onaitis, Mark W; Tyler, Douglas S; Pruitt, Scott K

    2005-04-01

    Cotransfection of dendritic cells (DC) with MART-1 and constitutively active TLR4 (caTLR4) RNA enhances the maturation of DC. Immature DC were cotransfected with RNA constructs encoding MART-1 and caTLR4, and CTL responses were analyzed. Cotransfection of DC with MART-1 + caTLR4 enhanced the expression of CD80 and CD83 surface markers and increased the secretion of cytokines IL-6, IL-12, and TNFalpha. Neither the native nor the A27L-modified MART-1 RNA could induce significant DC maturation or cytokine secretion. More importantly, DC cotransfected with caTLR4 + MART-1 RNA induced MART-1-specific CTL responses of a higher magnitude than DC transfected with either the native or A27L MART-1 RNA. When the MART-1 RNA-transfected DC were treated with DC-maturing cytokines, the induced CTL were less frequent and less lytic than those induced with MART-1 + caTLR4. A 2- to 100-fold increase in MART-1 tetramer+ cells and 2- to 10-fold increases in IFNgamma secretion and cytotoxicity were seen in CTL induced with MART-1 + caTLR4 compared to CTL induced with either MART-1 or A27L RNA. CTL induced with the mixed RNA displayed high percentages of CD8+ cells coexpressing CD45RA, CD56, and 2B4 antigens. Transfection with caTLR4 alone induced DC maturation, but did not induce lytic CTL, suggesting that CTL responses were induced solely by MART-1 epitopes. caTLR4 increases the CTL-inducing capacity of DC generating a lytic response specific for the accompanying antigen. These results demonstrate the possibility of enhancing the immunogenicity of the native MART-1 and other RNA derived from weakly immunogenic tumors in DC-based immunotherapy.

  5. Curiosity --El nuevo robot explorador de Marte

    NASA Image and Video Library

    El nuevo Laboratorio Científico de Marte llamado Curiosity tiene grandes preguntas que responder una vez que llegue a Marte. Infórmese sobre la misión con el analista de trayectoria de la NASA Fern...

  6. ARGOS: the laser guide star system for the LBT

    NASA Astrophysics Data System (ADS)

    Rabien, S.; Ageorges, N.; Barl, L.; Beckmann, U.; Blümchen, T.; Bonaglia, M.; Borelli, J. L.; Brynnel, J.; Busoni, L.; Carbonaro, L.; Davies, R.; Deysenroth, M.; Durney, O.; Elberich, M.; Esposito, S.; Gasho, V.; Gässler, W.; Gemperlein, H.; Genzel, R.; Green, R.; Haug, M.; Hart, M. L.; Hubbard, P.; Kanneganti, S.; Masciadri, E.; Noenickx, J.; Orban de Xivry, G.; Peter, D.; Quirrenbach, A.; Rademacher, M.; Rix, H. W.; Salinari, P.; Schwab, C.; Storm, J.; Strüder, L.; Thiel, M.; Weigelt, G.; Ziegleder, J.

    2010-07-01

    ARGOS is the Laser Guide Star adaptive optics system for the Large Binocular Telescope. Aiming for a wide field adaptive optics correction, ARGOS will equip both sides of LBT with a multi laser beacon system and corresponding wavefront sensors, driving LBT's adaptive secondary mirrors. Utilizing high power pulsed green lasers the artificial beacons are generated via Rayleigh scattering in earth's atmosphere. ARGOS will project a set of three guide stars above each of LBT's mirrors in a wide constellation. The returning scattered light, sensitive particular to the turbulence close to ground, is detected in a gated wavefront sensor system. Measuring and correcting the ground layers of the optical distortions enables ARGOS to achieve a correction over a very wide field of view. Taking advantage of this wide field correction, the science that can be done with the multi object spectrographs LUCIFER will be boosted by higher spatial resolution and strongly enhanced flux for spectroscopy. Apart from the wide field correction ARGOS delivers in its ground layer mode, we foresee a diffraction limited operation with a hybrid Sodium laser Rayleigh beacon combination.

  7. High Altitude Observatory YBJ and ARGO Project

    NASA Astrophysics Data System (ADS)

    Tan, Y.; ARGO Collaboration

    A 5800 m2 RPC (Resistive Plate Chamber) full coverage air shower array is under construction in the YangBaJing Cosmic Ray Observatory, Tibet of China, by the ChinaItaly ARGO Collaboration. YBJ is a large flat grassland with an area 10 × 70 km2 at 4300m altitude, about 90 north west from Lhasa. Its nearby power station, asphalt road to Lhasa, passing railway (will be constructed during the coming 5 years), optical fiber link to the INTERNET, rare snow and other favourable weather conditions are well suitable for setting an Astrophysical Observatory here. The installation of a large area carpet-like detector in this peculiar site will allow one to perform an all-sky and high duty cycle study of high energy gamma rays from 100GeV to 50 TeV as well as accurate measurements on UHE cosmic rays. To insure the stable and uniform working condition of RPCs, a 104 M2 carpet hall was constructed, the RPC installation have be started in it since last November. The natural distribution and daily variation of temperature in the hall, the data concerning the performances of the installed RPCs, have been measured, the results are presented. ce

  8. The vibration compensation system for ARGOS

    NASA Astrophysics Data System (ADS)

    Peter, D.; Gaessler, W.; Borelli, J.; Kulas, M.

    2011-09-01

    For every adaptive optics system telescope vibrations can strongly reduce the performance. This is true for the receiver part of the system i.e. the telescope and wave front sensor part as well as for the transmitter part in the case of a laser guide star system. Especially observations in deep fields observed with a laser guide star system without any tip-tilt star will be greatly spoiled by telescope vibrations. The ARGOS GLAO system actually being built for the LBT aims to implement this kind of mode where wave front correction will rely purely on signals from the laser beacons. To remove the vibrations from the uplink path a vibration compensation system will be installed. This system uses accelerometers to measure the vibrations and corrects their effect with a small fast tip-tilt mirror. The controller of the system is built based on the assumption that the vibrations take place at a few distinct frequencies. Here I present a lab set-up of this system and show first results of the performance.

  9. An Argo mixed layer climatology and database

    NASA Astrophysics Data System (ADS)

    Holte, James; Talley, Lynne D.; Gilson, John; Roemmich, Dean

    2017-06-01

    A global climatology and database of mixed layer properties are computed from nearly 1,250,000 Argo profiles. The climatology is calculated with both a hybrid algorithm for detecting the mixed layer depth (MLD) and a standard threshold method. The climatology provides accurate information about the depth, properties, extent, and seasonal patterns of global mixed layers. The individual profile results in the database can be used to construct time series of mixed layer properties in specific regions of interest. The climatology and database are available online at http://mixedlayer.ucsd.edu. The MLDs calculated by the hybrid algorithm are shallower and generally more accurate than those of the threshold method, particularly in regions of deep winter mixed layers; the new climatology differs the most from existing mixed layer climatologies in these regions. Examples are presented from the Labrador and Irminger Seas, the Southern Ocean, and the North Atlantic Ocean near the Gulf Stream. In these regions the threshold method tends to overestimate winter MLDs by approximately 10% compared to the algorithm.

  10. Diffraction limited operation with ARGOS: a hybrid AO system

    NASA Astrophysics Data System (ADS)

    Bonaglia, M.; Busoni, L.; Quirós-Pacheco, F.; Esposito, S.

    2010-07-01

    ARGOS, the Laser Guide Star (LGS) facility of the Large Binocular Telescope (LBT), implements a Ground Layer Adaptive Optics (GLAO) system, using 3 low-altitude beacons, to improve the resolution over the 4'×4' FoV of the imager and Multi Object Spectrograph (MOS) LUCIFER. In this paper we discuss the performance and the reconstruction scheme of an hybrid AO system using the ARGOS Rayleigh beacons complemented with a single faint high-altitude star (NGS or sodium beacon) to sense the turbulence of the upper atmosphere allowing an high degree of on-axis correction. With the ARGOS system, the NGS-upgrade can be immediately implemented at LBT using the already existing Pyramid WFS offering performance similar to the NGS AO system with the advantage of a larger sky coverage.

  11. Argos: A novel 3-DoF parallel wrist mechanism

    SciTech Connect

    Vischer, P.; Clavel, R.

    2000-01-01

    This article presents a novel parallel spherical mechanism called argos with three rotational degrees of freedom. Design aspects of the first prototype built of the Argos mechanism are discussed. The direct kinematic problem is solved, leading always to four nonsingular configurations of the end effector for a given set of joint angles. The inverse-kinematic problem yields two possible configurations for each of the three pantographs for a given orientation of the end effector. Potential applications of the Argos mechanism are robot wrists, orientable machine tool beds, joy sticks, surgical manipulators, and orientable units for optical components. Another pantograph based new structure named PantoScope having two rotational DoF is also briefly introduced.

  12. A global comparison of Argo and satellite altimetry observations

    NASA Astrophysics Data System (ADS)

    Dhomps, A.-L.; Guinehut, S.; Le Traon, P.-Y.; Larnicol, G.

    2010-05-01

    Differences and complementarities between Sea Level Anomalies (SLA) deduced from altimeter measurements and dynamic height anomalies (DHA) calculated from Argo in situ temperature (T) and salinity (S) profiles are globally analyzed. Compared to previous studies, Argo data allows a much better spatial coverage of all oceans and particularly the Southern Ocean, the use of salinity measurements and the use of a deeper reference level. The use of time series along the Argo float trajectories also provides a means to describe the vertical structure of the ocean both for the low frequency and the mesoscale part of the circulation. The comparison shows the very good consistency between Argo and altimeter observations. Correlations range from 0.9 in low latitudes to 0.3 in high latitudes where the contributions of deep baroclinic and barotropic signals are the largest. The study underlines the large influence of salinity observations on the consistency between altimetry and hydrographic observations. SLA/DHA consistency is thus improved by 35% (relative to the SLA minus DHA signal) by using measured S profiles instead of climatology data. The use of a deep reference level also significantly improves the correlation at mid and high latitudes. The role of seasonal signals on the correlation and regression analysis between altimeter and Argo observations is also analyzed. As they are mainly associated with the heating/cooling of surface layers, removing these large scale signals significantly reduces the correlation and impacts the geographical structure of the Argo/altimetry regression coefficients. These results emphasize the need to separate the different time and space scales in order to improve the merging of the two data sets. The study of seasonal to interannual SLA minus DHA signals finally reveals interesting signals related to deep ocean circulation variations. Future work is, however, needed to understand the observed differences and relate them to different

  13. A global comparison of Argo and satellite altimetry observations

    NASA Astrophysics Data System (ADS)

    Dhomps, A.-L.; Guinehut, S.; Le Traon, P.-Y.; Larnicol, G.

    2011-03-01

    Differences, similarities and complementarities between Sea Level Anomalies (SLA) deduced from altimeter measurements and dynamic height anomalies (DHA) calculated from Argo in situ temperature (T) and salinity (S) profiles are globally analyzed. SLA and DHA agree remarkably well and, compared to previous studies, Argo dataset allows an improvement in the coherence between SLA and DHA. Indeed, Argo data provides a much better spatial coverage of all oceans and particularly the Southern Ocean, the use of an Argo mean dynamic height, the use of measured salinity profiles (versus climatological salinity), and the use of a deeper reference level (1000 m versus 700 m). The large influence of Argo salinity observations on the consistency between altimetry and hydrographic observations is particularly demonstrated with an improvement of 35% (relative to the SLA minus DHA signal) by using measured salinity profiles instead of climatological data. The availability of observations along the Argo float trajectories also provides a means to describe the sea level variability of the global ocean both for the low frequency and the mesoscale part of the circulation. Results indicate that sea level variability is dominated by baroclinic signal at seasonal to inter-annual periods for all latitudes. In the tropics, sea level variability is baroclinic for meso-scale to interannual periods and at high latitudes, sea level variability is barotropic with also deep baroclinic signals (i.e. influence of deep temperature and salinity signals) for intra seasonal and mesoscale periods. These results emphasize the need to separate the different time and space scales in order to improve the merging of the two data sets. The qualitative study of seasonal to interannual SLA minus DHA signals finally reveals signals related to deep ocean circulation variations and basin-scale barotropic signals. Future work is, however, needed to understand the observed differences and relate them to different

  14. The international Argo data infrastructure; past, present, and future.

    NASA Astrophysics Data System (ADS)

    Buck, J. J. H.; Pouliquen, S.; Thresher, A.; Schmechtig, C.; Ignaszewski, M.; Carval, T.; Scanderbeg, M.; Frost, M.

    2016-12-01

    The Argo array is composed of over 3,000 autonomous profiling floats that measure the temperature and salinity of the upper 2,000 m of the global deep ocean every ten days. Argo is a key component of the global ocean observing system and the data addresses crucial questions such as quantifying the heat content of the upper ocean and steric sea level change. Further to this data are routinely assimilated into operational ocean forecast models. Argo is underpinned by an international data system that was founded in the year 2,000 at the first meeting of the Argo data management team. The Argo data system is built on principles of open data and supplying data to both operational ocean models and research communities within 24 hours of collection. The data system served as a template for the established international OceanSITES community and the emerging Everyones Glider Observatories initiative. The Argo data system is composed of national Data Assembly Centers (DAC) that supply data to two mirrored Global Data Assembly Centres (GDAC). GDAC data exchanges are based on File Transfer Protocol (FTP). A significant recent data system development is the assignment of a single dynamic DOI to GDAC holdings enabling time dependent unambiguous data citation at a monthly granularity. The on-going evolution of Argo to address new global questions requires deeper data, shallower data, biogeochemical sampling and increased spatial coverage. These enhancements are increasing data complexity and volumes necessitating significant recent data format adaptation. The challenge and achievement was to preserve data formats and quality for existing established users while still allowing the integration of new data streams. The implementation of these adaptations is currently in progress within DACs. Argo data have been traditionally delivered via FTP protocol with developments are on-going to facilitate new users and emerging expectations on data delivery mechanisms. These experimental

  15. Status of the ARGOS ground layer adaptive optics system

    NASA Astrophysics Data System (ADS)

    Gässler, Wolfgang; Rabien, Sebastian; Esposito, Simone; Lloyd-Hart, Michael; Barl, Lothar; Beckmann, Udo; Bluemchen, Thomas; Bonaglia, Marco; Borelli, José Luis; Brusa, Guido; Brynnel, Joar; Buschkamp, Peter; Busoni, Lorenzo; Carbonaro, Luca; Connot, Claus; Davies, Richard; Deysenroth, Matthias; Durney, Olivier; Green, Richard; Gemperlein, Hans; Gasho, Victor; Haug, Marcus; Hubbard, Pete; Ihle, Sebastian; Kulas, Martin; Lederer, Reinhard; Lewis, Jason; Loose, Christina; Lehmitz, Michael; Noenickx, Jamison; Nussbaum, Edmund; Orban de Xivry, Gilles; Peter, Diethard; Quirrenbach, Andreas; Rademacher, Matt; Raab, Walfried; Storm, Jesper; Schwab, Christian; Vaitheeswaran, Vidhya; Ziegleder, Julian

    2012-07-01

    ARGOS the Advanced Rayleigh guided Ground layer adaptive Optics System for the LBT (Large Binocular Telescope) is built by a German-Italian-American consortium. It will be a seeing reducer correcting the turbulence in the lower atmosphere over a field of 2' radius. In such way we expect to improve the spatial resolution over the seeing of about a factor of two and more and to increase the throughput for spectroscopy accordingly. In its initial implementation, ARGOS will feed the two near-infrared spectrograph and imager - LUCI I and LUCI II. The system consist of six Rayleigh lasers - three per eye of the LBT. The lasers are launched from the back of the adaptive secondary mirror of the LBT. ARGOS has one wavefront sensor unit per primary mirror of the LBT, each of the units with three Shack-Hartmann sensors, which are imaged on one detector. In 2010 and 2011, we already mounted parts of the instrument at the telescope to provide an environment for the main sub-systems. The commissioning of the instrument will start in 2012 in a staged approach. We will give an overview of ARGOS and its goals and report about the status and new challenges we encountered during the building phase. Finally we will give an outlook of the upcoming work, how we will operate it and further possibilities the system enables by design.

  16. Implementation of SLODAR atmospheric turbulence profiling to the ARGOS system

    NASA Astrophysics Data System (ADS)

    Mazzoni, Tommaso; Busoni, Lorenzo; Bonaglia, Marco; Esposito, Simone

    2014-08-01

    ARGOS is the Ground Layer Adaptive Optics system of the Large Binocular Telescope, it uses three Laser Guide Stars at 12 km altitude, generated by Rayleigh backscattered light of pulsed Nd:YAG lasers at 532nm. The wavefront distortion in the Ground Layer is measured by three Shack-Hartmann WFS, sampling with 15×15 subaperture the three LGS arranged on a single CCD with 8×8px per square subaperture. The SLOpe Detection And Ranging (SLODAR) is a method used to measure the turbulence profiles. Cross correlation of wavefronts gradient from multiple stars is used to estimate the relative strengths of turbulent layers at different altitudes. In the ARGOS case the LGS are arranged on a triangle inscribed in a 2 arcmin radius circle, so we expect an effective slopes correlation up to 5km altitude. We present here the results of a study aimed to implement the SLODAR method on ARGOS performed with the idl-based simulation code used to characterize the ARGOS performance. Simulation implements the atmospheric turbulence on different layers with variable strength, altitude and wind speed. The algorithm performance are evaluated comparing the input turbulence with the cross-correlation of the SH slopes acquired in open loop.

  17. Maize and Arabidopsis ARGOS Proteins Interact with Ethylene Receptor Signaling Complex, Supporting a Regulatory Role for ARGOS in Ethylene Signal Transduction.

    PubMed

    Shi, Jinrui; Drummond, Bruce J; Wang, Hongyu; Archibald, Rayeann L; Habben, Jeffrey E

    2016-08-01

    The phytohormone ethylene regulates plant growth and development as well as plant response to environmental cues. ARGOS genes reduce plant sensitivity to ethylene when overexpressed in transgenic Arabidopsis (Arabidopsis thaliana) and maize (Zea mays). A previous genetic study suggested that the endoplasmic reticulum and Golgi-localized maize ARGOS1 targets the ethylene signal transduction components at or upstream of CONSTITUTIVE TRIPLE RESPONSE1, but the mechanism of ARGOS modulating ethylene signaling is unknown. Here, we demonstrate in Arabidopsis that ZmARGOS1, as well as the Arabidopsis ARGOS homolog ORGAN SIZE RELATED1, physically interacts with Arabidopsis REVERSION-TO-ETHYLENE SENSITIVITY1 (RTE1), an ethylene receptor interacting protein that regulates the activity of ETHYLENE RESPONSE1. The protein-protein interaction was also detected with the yeast split-ubiquitin two-hybrid system. Using the same yeast assay, we found that maize RTE1 homolog REVERSION-TO-ETHYLENE SENSITIVITY1 LIKE4 (ZmRTL4) and ZmRTL2 also interact with maize and Arabidopsis ARGOS proteins. Like AtRTE1 in Arabidopsis, ZmRTL4 and ZmRTL2 reduce ethylene responses when overexpressed in maize, indicating a similar mechanism for ARGOS regulating ethylene signaling in maize. A polypeptide fragment derived from ZmARGOS8, consisting of a Pro-rich motif flanked by two transmembrane helices that are conserved among members of the ARGOS family, can interact with AtRTE1 and maize RTL proteins in Arabidopsis. The conserved domain is necessary and sufficient to reduce ethylene sensitivity in Arabidopsis and maize. Overall, these results suggest a physical association between ARGOS and the ethylene receptor signaling complex via AtRTE1 and maize RTL proteins, supporting a role for ARGOS in regulating ethylene perception and the early steps of signal transduction in Arabidopsis and maize.

  18. Maize and Arabidopsis ARGOS Proteins Interact with Ethylene Receptor Signaling Complex, Supporting a Regulatory Role for ARGOS in Ethylene Signal Transduction[OPEN

    PubMed Central

    Shi, Jinrui; Wang, Hongyu; Habben, Jeffrey E.

    2016-01-01

    The phytohormone ethylene regulates plant growth and development as well as plant response to environmental cues. ARGOS genes reduce plant sensitivity to ethylene when overexpressed in transgenic Arabidopsis (Arabidopsis thaliana) and maize (Zea mays). A previous genetic study suggested that the endoplasmic reticulum and Golgi-localized maize ARGOS1 targets the ethylene signal transduction components at or upstream of CONSTITUTIVE TRIPLE RESPONSE1, but the mechanism of ARGOS modulating ethylene signaling is unknown. Here, we demonstrate in Arabidopsis that ZmARGOS1, as well as the Arabidopsis ARGOS homolog ORGAN SIZE RELATED1, physically interacts with Arabidopsis REVERSION-TO-ETHYLENE SENSITIVITY1 (RTE1), an ethylene receptor interacting protein that regulates the activity of ETHYLENE RESPONSE1. The protein-protein interaction was also detected with the yeast split-ubiquitin two-hybrid system. Using the same yeast assay, we found that maize RTE1 homolog REVERSION-TO-ETHYLENE SENSITIVITY1 LIKE4 (ZmRTL4) and ZmRTL2 also interact with maize and Arabidopsis ARGOS proteins. Like AtRTE1 in Arabidopsis, ZmRTL4 and ZmRTL2 reduce ethylene responses when overexpressed in maize, indicating a similar mechanism for ARGOS regulating ethylene signaling in maize. A polypeptide fragment derived from ZmARGOS8, consisting of a Pro-rich motif flanked by two transmembrane helices that are conserved among members of the ARGOS family, can interact with AtRTE1 and maize RTL proteins in Arabidopsis. The conserved domain is necessary and sufficient to reduce ethylene sensitivity in Arabidopsis and maize. Overall, these results suggest a physical association between ARGOS and the ethylene receptor signaling complex via AtRTE1 and maize RTL proteins, supporting a role for ARGOS in regulating ethylene perception and the early steps of signal transduction in Arabidopsis and maize. PMID:27268962

  19. A data mart for operations analysis.

    PubMed

    Isken, M W; Littig, S J; West, M

    2001-01-01

    In this article we describe the evolution and architecture of a data mart developed to address the modeling and analysis needs of healthcare operations analysts. More specifically, the data mart is used in projects relating to demand analysis, forecasting, capacity planning, and service system design for a healthcare system consisting of a large tertiary care hospital and a smaller community hospital. The primary focus of the mart is on the detailed movement of inpatients through each hospital, although most component data tables include outpatient information such as emergency center visits, surgical cases, cardiac catheterization cases, and short-stay visits. We show that the data mart goes well beyond consolidating data from different sources by including a number of complex, precalculated fields, data structures, and function libraries that are specific to the needs of operations analysts. We discuss several outstanding and challenging design issues that should be of interest to the data warehouse vendor community.

  20. Wal-Mart Experience: Part One

    SciTech Connect

    MacDonald, M.; Deru, M.

    2007-09-01

    In 2005, Wal-Mart opened experimental stores in McKinney, Texas (hot climate), and Aurora, Colo. (cold climate). With these projects Wal-Mart can: (1)Learn how to achieve sustainability improvements, (2)Gain experience with the design, design process, and operations for some specific advanced technologies, (3)Understand energy use patterns in their stores more clearly, (4)Lay groundwork for better understanding of how to achieve major carbon footprint reductions; and (5)Measure the potential benefits of specific technologies tested.

  1. Argos and Spitz group genes function to regulate midline glial cell number in Drosophila embryos.

    PubMed

    Stemerdink, C; Jacobs, J R

    1997-10-01

    The midline glia of the Drosophila embryonic nerve cord undergo a reduction in cell number after facilitating commissural tract morphogenesis. The numbers of midline glia entering apoptosis at this stage can be increased by a loss or reduction of function in genes of the spitz group or Drosophila EGF receptor (DER) pathway. Argos, a secreted molecule with an atypical EGF motif, is postulated to function as a DER antagonist. In this work, we assess the role of argos in the determination of midline glia cell number. Although all midline glia express DER, argos expression is restricted to the midline glia which do not enter apoptosis. Fewer midline glia enter apoptosis in embryos lacking argos function. Ectopic expression of argos is sufficient to remove all DER-expressing midline glia from the nerve cord, even those that already express argos. DER expression is not terminated in the midline glia after spitz group signaling triggers changes in gene expression. It is therefore likely that an attenuation of DER signaling by Argos is integrated with the augmentation of DER signaling by Spitz throughout the period of reduction of midline glia number. We suggest that signaling by Spitz but not Argos is restricted to adhesive junctions. In this manner, midline glia not forming signaling junctions remain sensitive to juxtacrine Argos signaling, while an autocrine Argos signal is excluded by the adhesive junction.

  2. Argos mutants define an affinity threshold for spitz inhibition in vivo.

    PubMed

    Alvarado, Diego; Evans, Timothy A; Sharma, Raghav; Lemmon, Mark A; Duffy, Joseph B

    2006-09-29

    Argos, a secreted antagonist of Drosophila epidermal growth factor receptor (dEGFR) signaling, acts by sequestering the activating ligand Spitz. To understand how different domains in Argos contribute to efficient Spitz sequestration, we performed a genetic screen aimed at uncovering modifiers of an Argos misexpression phenotype in the developing eye. We identified a series of suppressors mapping to the Argos transgene that affect its activity in multiple developmental contexts. These point mutations map to both the N- and C-terminal cysteine-rich regions, implicating both domains in Argos function. We show by surface plasmon resonance that these Argos mutants are deficient in their ability to bind Spitz in vitro. Our data indicate that a mere approximately 2-fold decrease in K(D) is sufficient to compromise Argos activity in vivo. This effect could be recapitulated in a cell-based assay, where a higher molar concentration of mutant Argos was needed to inhibit Spitz-dependent dEGFR phosphorylation. In contrast, a approximately 37-fold decrease in the binding constant nearly abolishes Argos activity in vivo and in cellular assays. In agreement with previously reported computational studies, our results define an affinity threshold for optimal Argos inhibition of dEGFR signaling during development.

  3. The Drosophila secreted protein Argos regulates signal transduction in the Ras/MAPK pathway.

    PubMed

    Sawamoto, K; Okabe, M; Tanimura, T; Mikoshiba, K; Nishida, Y; Okano, H

    1996-08-25

    The Drosophila argos gene encodes a secreted protein with an EGF motif which acts as an inhibitor of cellular differentiation in multiple developmental processes. To investigate the cellular pathways regulated by Argos, we screened for mutations which could modify the phenotype caused by overexpression of argos. We show that the effects of argos overexpression on the eye and wing vein development are suppressed by gain-of-function mutations of the MAPKK/D-MEK gene (Dsor1/D-mek) and the MAPK/ERK-A gene (rolled) and were enhanced by loss-of-function mutations of Star. Loss-of-function mutations in components of the Ras/MAPK signaling cascade act as dominant suppressors of the phenotype caused by the argos null mutations. A loss-of-function argos mutation enhanced the overproduction of R7 neurons caused by gain-of-function alleles of Son of sevenless and Dsor1. Conversely, overexpression of argos inhibited formation of the extra R7 cells that was caused by high-level MAPK/ERK-A activity. A phenotype of the sev; argos double mutants revealed that sev is epistatic to argos. These results provide evidence that Argos negatively regulates signal transduction events in the Ras/MAPK cascade.

  4. The Euro-Argo education web site: using Argo data to teach data analysis and marine science

    NASA Astrophysics Data System (ADS)

    Byfield, Valborg; Scheurle, Carolyn; Gould, John; Macama, Emina; King, Brian

    2013-04-01

    The Euro-Argo education website (www.euroargo-edu.org) aims to make Argo and its data accessible to a non-specialist audience. The site is centred on a selection of floats, which have been chosen because of the insight they provide into key oceanographic processes, the physical and biogeochemical characteristics of different ocean regions around the world, and the role of the ocean in the global climate system. The float selection is a vehicle for teaching data analysis skills, linking these to current topics in the ocean and climate sciences. Each float in the selection has its own page, which provides access to the float data, data plots, background information on the ocean region in which the float can be found, and questions to guide data interpretation. Hidden 'model answers' allow users to check their understanding by comparing their own answers to those provided. The interactive component of the site also includes a series of quizzes, designed to teach data interpretation skills. These start at a basic level and take the students step by step through the most common ways to plot oceanographic data in space and time. More general background information covers the main aspects of the Argo programme, its history and applications, and basic technical information about the floats and sensors. 'World Tour' pages linked to the float selection provide information about the main ocean regions and link information from the Argo programme to oceanographic information from other sources such as satellite observations. The site is primarily aimed at young people between 11 and 18 years of age. However experience from using selected material from the site during science open days shows that children as young as 8-9 and adults of all ages also enjoy the challenge of using and interpreting the Argo data in different contexts.

  5. Taxonomy of the subgenus Euleptarthrus Jakobson (Coleoptera, Staphylinidae, Osoriinae, Priochirus) of China with descriptions of three new species.

    PubMed

    Wu, Jie; Zhou, Hong-Zhang

    2013-02-08

    Three new species of subgenus Euleptarthrus Jakobson, 1908 of the genus Priochirus Sharp, 1887 are described from China: P. (E.) trifurcus Wu & Zhou sp. nov. from Xizang, P. (E.) deltodontus Wu & Zhou sp. nov. from Yunnan and P. (E.) curtidentatus Wu & Zhou sp. nov. from Xizang and Yunnan. Diagnoses are also given for two species previously described from China, P. (E.) chinensis Bernhauer, 1933 and P. (E.) subbrevicornis Bernhauer, 1934. An updated version of the key to all Chinese species of the subgenus Euleptarthrus is provided. Important morphological characters are illustrated.

  6. The function of the Drosophila argos gene product in the development of embryonic chordotonal organs.

    PubMed

    Okabe, M; Sawamoto, K; Okano, H

    1996-04-10

    We characterized the embryonic expression pattern and mutant phenotypes of the Drosophila gene argos, which encodes a secreted protein with an epidermal growth factor motif. The argos null mutation caused an increase in chordotonal (Ch) organs in both the thoracic and the abdominal segments, whereas overexpression of the argos gene resulted in a decrease in these organs. We showed that the argos transcripts are expressed transiently in the cells surrounding the Ch organ precursor and that the gene rhomboid (rho), which is involved in the regulation of the number of Ch organs, acts epistatically to argos in this event. Our findings suggest that argos plays a role in Ch organ precursor formation and regulates the final number of Ch organs.

  7. A Genetic Analysis of the Drosophila Closely Linked Interacting Genes Bulge, Argos and Soba

    PubMed Central

    Wemmer, T.; Klambt, C.

    1995-01-01

    The Drosophila gene argos encodes a diffusible protein that acts as a negative regulator of cell fate decisions. To define interacting gene products, we performed a genetic analysis of argos, which suggests the presence of several partially redundant gene functions in its immediate vicinity at the chromosomal position 73A. Dose titration experiments have identified two of these loci. One of them corresponds to the gene bulge. Loss of function bulge alleles suppress the rough eye phenotype associated with overexpression of argos; conversely, amorphic argos mutations suppress the eye phenotype seen in flies bearing a single dominant bulge allele. Recombination mapping localized bulge 0.15 cM distal to argos. A second gene, suppressor of bulge and argos (soba), corresponds to the recently described lethal complementation group 73Aj. soba alleles suppress the eye phenotypes seen in flies expressing either the dominant bulge allele or the hs-argos construct. soba resides 120 kb proximal to argos. In addition, we have identified one allele of a new gene, clown, which like soba suppresses the eye phenotypes associated with hs-argos and bulge(Dominant). clown maps on chromosome 3 at the cytological position 68CD. PMID:7498742

  8. Molecular and Functional Characterization of Wheat ARGOS Genes Influencing Plant Growth and Stress Tolerance.

    PubMed

    Zhao, Yue; Tian, Xuejun; Li, Yuanyuan; Zhang, Liyuan; Guan, Panfeng; Kou, Xiaoxia; Wang, Xiaobo; Xin, Mingming; Hu, Zhaorong; Yao, Yingyin; Ni, Zhongfu; Sun, Qixin; Peng, Huiru

    2017-01-01

    Auxin Regulated Gene involved in Organ Size (ARGOS) is significantly and positively associated with organ size and is involved in abiotic stress responses in plants. However, no studies on wheat ARGOS genes have been reported to date. In the present study, three TaARGOS homoeologous genes were isolated and located on chromosomes 4A, 4B, and 4D of bread wheat, all of which are highly conserved in wheat and its wild relatives. Comparisons of gene expression in different tissues demonstrated that the TaARGOSs were mainly expressed in the stem. Furthermore, the TaARGOS transcripts were significantly induced by drought, salinity, and various phytohormones. Transient expression of the TaARGOS-D protein in wheat protoplasts showed that TaARGOS-D localized to the endoplasmic reticulum. Moreover, overexpression of TaARGOS-D in Arabidopsis resulted in an enhanced germination rate, larger rosette diameter, increased rosette leaf area, and higher silique number than in wild-type (WT) plants. The roles of TaARGOS-D in the control of plant growth were further studied via RNA-seq, and it was found that 105 genes were differentially expressed; most of these genes were involved in 'developmental processes.' Interestingly, we also found that overexpression of TaARGOS-D in Arabidopsis improved drought and salinity tolerance and insensitivity to ABA relative to that in WT plants. Taken together, these results demonstrate that the TaARGOSs are involved in seed germination, seedling growth, and abiotic stress tolerance.

  9. A genetic analysis of the Drosophila closely linked interacting genes bulge, argos and soba.

    PubMed

    Wemmer, T; Klämbt, C

    1995-06-01

    The Drosophila gene argos encodes a diffusible protein that acts as a negative regulator of cell fate decisions. To define interacting gene products, we performed a genetic analysis of argos, which suggests the presence of several partially redundant gene functions in its immediate vicinity at the chromosomal position 73A. Dose titration experiments have identified two of these loci. One of them corresponds to the gene bulge. Loss of function bulge alleles suppress the rough eye phenotype associated with overexpression of argos; conversely, amorphic argos mutations suppress the eye phenotype seen in flies bearing a single dominant bulge allele. Recombination mapping localized bulge 0.15 cM distal to argos. A second gene, suppressor of bulge and argos (soba), corresponds to the recently described lethal complementation group 73Aj. soba alleles suppress the eye phenotypes seen in flies expressing either the dominant bulge allele or the hs-argos construct. soba resides 120 kb proximal to argos. In addition, we have identified one allele of a new gene, clown, which like soba suppresses the eye phenotypes associated with hs-argos and bulgeDominant. clown maps on chromosome 3 at the cytological position 68CD.

  10. Exclusive µ+Np topologies with ArgoNeuT

    SciTech Connect

    Partyka, Kinga

    2015-05-15

    The Argon Neutrino Test, ArgoNeuT, is a small scale Liquid Argon Time Projection Chamber (LAr TPC) that is one step towards the construction of large scale LAr TPCs for long-baseline neutrino physics. LArTPCs provide bubble-chamber-like quality images for excellent particle ID and background rejection. Due to its superb capabilities it is well suited for topological analysis by reporting what it sees in a final state. Preliminary analysis of ArgoNeuT’s 0.1 to 10 GeV neutrino µ+Np topologies together with first ever study of proton multiplicities in neutrino-argon interactions was presented and compared with GENIE Monte Carlo generator.

  11. Detection of EASs at high altitude with ARGO-YBJ

    NASA Astrophysics Data System (ADS)

    Di Sciascio, Giuseppe

    2017-06-01

    The ARGO-YBJ experiment has been in stable data taking for about 5 years at the YangBaJing Cosmic Ray Observatory (Tibet, P.R. China, 4300 m a.s.l., 606 g/cm2). With a duty-cycle greater than 86% the detector collected about 5×1011 events in a wide energy range, from few hundreds GeV up to about 10 PeV. Exploiting the full coverage approach with a high segmentation of the readout at high altitude, ARGO-YBJ imaged the front of Extensive Air Showers (EAS) with unprecedented resolution and detail. A number of important problems in galactic cosmic ray physics has been faced through different analyses. In this contribution we summarize the latest results in gamma-ray astronomy and in cosmic ray physics.

  12. Horizontal mixing in the Southern Ocean from Argo float trajectories

    NASA Astrophysics Data System (ADS)

    Roach, Christopher J.; Balwada, Dhruv; Speer, Kevin

    2016-08-01

    We provide the first observational estimate of the circumpolar distribution of cross-stream eddy diffusivity at 1000 m in the Southern Ocean using Argo float trajectories. We show that Argo float trajectories, from the float surfacing positions, can be used to estimate lateral eddy diffusivities in the ocean and that these estimates are comparable to those obtained from RAFOS floats, where they overlap. Using the Southern Ocean State Estimate (SOSE) velocity fields to advect synthetic particles with imposed behavior that is "Argo-like" and "RAFOS-like" diffusivity estimates from both sets of synthetic particles agreed closely at the three dynamically very different test sites, the Kerguelen Island region, the Southeast Pacific Ocean, and the Scotia Sea, and support our approach. Observed cross-stream diffusivities at 1000 m, calculated from Argo float trajectories, ranged between 300 and 2500 m2 s-1, with peaks corresponding to topographic features associated with the Scotia Sea, the Kerguelen Plateau, the Campbell Plateau, and the Southeast Pacific Ridge. These observational estimates agree with previous regional estimates from the Diapycnal and Isopycnal Mixing Experiment in the Southern Ocean (DIMES) near the Drake Passage, and other estimates from natural tracers (helium), inverse modeling studies, and current meter measurements. These estimates are also compared to the suppressed eddy diffusivity in the presence of mean flows. The comparison suggests that away from regions of strong topographic steering suppression explains both the structure and magnitude of eddy diffusivity but that eddy diffusivities in the regions of topographic steering are greater than what would be theoretically expected and the ACC experiences localized enhanced cross-stream mixing in these regions.

  13. The Large Binocular Telescope's ARGOS ground-layer AO system

    NASA Astrophysics Data System (ADS)

    Hart, M.; Rabien, S.; Busoni, L.; Barl, L.; Bechmann, U.; Bonaglia, M.; Boose, Y.; Borelli, J.; Bluemchen, T.; Carbonaro, L.; Connot, C.; Deysenroth, M.; Davies, R.; Durney, O.; Elberich, M.; Ertl, T.; Esposito, S.; Gaessler, W.; Gasho, V.; Gemperlein, H.; Hubbard, P.; Kanneganti, S.; Kulas, M.; Newman, K.; Noenickx, J.; de Xivry, G.; Qirrenback, A.; Rademacher, M.; Schwab, C.; Storm, J.; Vaitheeswaran, V.; Weigelt, G.; Ziegleder, J.

    2011-09-01

    ARGOS, the laser-guided adaptive optics system for the Large Binocular Telescope (LBT), is now under construction at the telescope. By correcting atmospheric turbulence close to the telescope, the system is designed to deliver high resolution near infrared images over a field of 4 arc minute diameter. ARGOS is motivated by a successful prototype multi-laser guide star system on the 6.5 m MMT telescope, results from which are presented in this paper. At the LBT, each side of the twin 8.4 m aperture is being equipped with three Rayleigh laser guide stars derived from six 18 W pulsed green lasers and projected into two triangular constellations matching the size of the corrected field. The returning light is to be detected by wavefront sensors that are range gated within the seeinglimited depth of focus of the telescope. Wavefront correction will be introduced by the telescope’s deformable secondary mirrors driven on the basis of the average wavefront errors computed from the respective guide star constellation. Measured atmospheric turbulence profiles from the site lead us to expect that by compensating the ground-layer turbulence, ARGOS will deliver median image quality of about 0.2 arc sec in the near infrared bands. This will be exploited by a pair of multi-object near-IR spectrographs, LUCI1 and LUCI2, each with 4 arc minute field already operating on the telescope. In future, ARGOS will also feed two interferometric imaging instruments, the LBT Interferometer operating in the thermal infrared, and LINC-NIRVANA, operating at visible and near infrared wavelengths. Together, these instruments will offer very broad spectral coverage at the diffraction limit of the LBT’s combined aperture, 23 m in size.

  14. Vibration control for the ARGOS laser launch path

    NASA Astrophysics Data System (ADS)

    Peter, Diethard; Gässler, Wolfgang; Borelli, Jose; Barl, Lothar; Rabien, S.

    2012-07-01

    Present and future adaptive optics systems aim for the correction of the atmospheric turbulence over a large field of view combined with large sky coverage. To achieve this goal the telescope is equipped with multiple laser beacons. Still, to measure tip-tilt aberrations a natural guide star is used. For some fields such a tilt-star is not available and a correction on the laser beacons alone is applied. For this method to work well the laser beacons must not be affected by telescope vibrations on their up-link path. For the ARGOS system the jitter of the beacons is specified to be below 0.05. To achieve this goal a vibration compensation system is necessary to mitigate the mechanical disturbances. The ARGOS vibration compensation system is an accelerometer based feed forward system. The accelerometer measurements are fed into a real time controller. To achieve high performance the controller of the system is model based. The output is applied to a fast steering mirror. This paper presents the concept of the ARGOS vibration compensation, the hardware, and laboratory results.

  15. Population Dynamics of the Stationary Phase Utilizing the ARGOS Method

    NASA Astrophysics Data System (ADS)

    Algarni, S.; Charest, A. J.; Iannacchione, G. S.

    2015-03-01

    The Area Recorded Generalized Optical Scattering (ARGOS) approach to light scattering employs large image capture array allowing for a well-defined geometry in which images may be manipulated to extract structure with intensity at a specific scattering wave vector (I(q)) and dynamics with intensity at a specific scattering wave vector over time (I (q,t)). The ARGOS method provides morphological dynamics noninvasively over a long time period and allows for a variety of aqueous conditions. This is important because traditional growth models do not provide for conditions similar to the natural environment. The present study found that the population dynamics of bacteria do not follow a traditional growth model and that the ARGOS method allowed for the observation of bacterial changes in terms of individual particles and population dynamics in real time. The observations of relative total intensity suggest that there is no stationary phase and that the bacterial population demonstrates sinusoidal type patterns consistently subsequent to the log phase growth. These observation were compared to shape changes by modeling fractal dimension and size changes by modeling effective radius.

  16. Radiotracking large wilderness mammals: Integration of GPS and Argos technology

    USGS Publications Warehouse

    Schwartz, Charles C.; Arthur, Steve M.

    1999-01-01

    We tested 30 prototype global positioning system (GPS) radiocollars on brown bears (Ursus arctos) over a 3-year period on the Kenai Peninsula, Alaska. Collars were of 2 design types: GPS with an Argos (Argos Data collection and Location System) satellite uplink (n=19) and GPS unites where the data were stored on board (n=10) for retrieval at a later date. All units also contained a conventional VHF (very high frequency) transmitter and weighed 1.7 kg. GPS-Argos united obtained 10-82% of expected GPS fixes, and fix rate declined significantly (P<0.05) with time after deployment. Argos uplink success (proportion of successful transmissions of stored data) was linearly related to GPS fix rate (r=0.91, P<0.001). Store-on-board units obtained significantly more successful fixes when compared with the GPS-Argos units (t=-4.009, P<0.001). Fix success rate for deployed store-on-board collars ranged from 13-96%; because of the increased number of attempted fixes per day, these collars obtained fixes on 97% of days deployed. Accuracy of the GPS units was less than predicted by the NAVSTAR GPS technology using the course acquisition code. Reduced accuracy was likely a result of the proportion of 2-dimensional versus 3-dimensional fixes obtained, although we could not determine this statistic from recorded data. Increased overstory closure was the only variable measured that partially explained the reduced likelihood of a successful fix. Stem density, stem diameter, and overstory height measured within 3 m of the collar did not affect fix success. GPS fix success rates for collars attached to bears varied more and were lower than fix rates for stationary collars placed in various vegetation types, suggesting that the bear, terrain, and movement all influence both fix and uplink success rate. Application of this new technology to grizzly and brown bear research and comparisons to studies with moose (Alces alces) are discussed.

  17. Estimating upper ocean phosphate concentrations using ARGO float temperature profiles

    NASA Astrophysics Data System (ADS)

    Kamykowski, Daniel

    2008-11-01

    The ARGO free-drifting profiling float array, with >3125 floats deployed between 60°N and 60°S latitudes at about 3° resolution as of May 2008 and each float profiling through 2000 m every 10 days, provides a comprehensive four-dimensional view of temperature and salinity in the world ocean. The resulting dataset complements satellite-based sea surface temperature (SST) measurements and similarly will complement future satellite-based sea surface salinity measurements. Although plans exist to add biogeochemical sensors to future floats, cost and depth restrictions may limit comprehensive upgrades to a fraction of all floats deployed after 2008. Temperature-nutrient (TN) relationships provide a mechanism to estimate nutrient concentrations from temperature to supplement sparser nutrient concentration measurements potentially obtained using non-chemical approaches like ISUS-based nitrate. Both negative and positive aspects of applying a temperature-phosphate (TP) linear regression matrix with global coverage (70°N and 70°S) are examined. The TP linear regression matrix was derived by combining an existing 1° latitude and longitude table of phosphate depletion temperatures (PDT) or X-intercepts with representative TP linear regression slopes derived from the GEOSECS dataset. Temperatures from datasets with associated latitude and longitude coordinates and, in some cases, measured phosphate concentrations ([PO 4]) were matched with calculated TP linear regression slopes and Y-intercepts in the global matrix with 1° resolution using MSExcel Lookup worksheet functions to calculate TP-estimated [PO 4]. The mean deviation of TP-estimated [PO 4] <3.0 μM from measured [PO 4] is 0.18±0.18 μM at Hawaii (HOT) and 0.04±0.08 μM at Bermuda (BATS) time series stations and 0.28±0.27 μM over all considered World Ocean Circulation Experiment (WOCE) stations representing the different ocean basins. In general, TP-estimated [PO 4] represents measured [PO 4] more accurately

  18. ARGOS8 variants generated by CRISPR-Cas9 improve maize grain yield under field drought stress conditions.

    PubMed

    Shi, Jinrui; Gao, Huirong; Wang, Hongyu; Lafitte, H Renee; Archibald, Rayeann L; Yang, Meizhu; Hakimi, Salim M; Mo, Hua; Habben, Jeffrey E

    2017-02-01

    Maize ARGOS8 is a negative regulator of ethylene responses. A previous study has shown that transgenic plants constitutively overexpressing ARGOS8 have reduced ethylene sensitivity and improved grain yield under drought stress conditions. To explore the targeted use of ARGOS8 native expression variation in drought-tolerant breeding, a diverse set of over 400 maize inbreds was examined for ARGOS8 mRNA expression, but the expression levels in all lines were less than that created in the original ARGOS8 transgenic events. We then employed a CRISPR-Cas-enabled advanced breeding technology to generate novel variants of ARGOS8. The native maize GOS2 promoter, which confers a moderate level of constitutive expression, was inserted into the 5'-untranslated region of the native ARGOS8 gene or was used to replace the native promoter of ARGOS8. Precise genomic DNA modification at the ARGOS8 locus was verified by PCR and sequencing. The ARGOS8 variants had elevated levels of ARGOS8 transcripts relative to the native allele and these transcripts were detectable in all the tissues tested, which was the expected results using the GOS2 promoter. A field study showed that compared to the WT, the ARGOS8 variants increased grain yield by five bushels per acre under flowering stress conditions and had no yield loss under well-watered conditions. These results demonstrate the utility of the CRISPR-Cas9 system in generating novel allelic variation for breeding drought-tolerant crops.

  19. The Arabidopsis auxin-inducible gene ARGOS controls lateral organ size.

    PubMed

    Hu, Yuxin; Xie, Qi; Chua, Nam-Hai

    2003-09-01

    During plant development, the final size of an organ is regulated and determined by various developmental signals; however, the molecular mechanisms by which these signals are transduced and the mediators involved are largely unknown. Here, we show that ARGOS, a novel Arabidopsis gene that is highly induced by auxin, is involved in organ size control. Transgenic plants expressing sense or antisense ARGOS cDNA display enlarged or reduced aerial organs, respectively. The alteration in organ size is attributable mainly to changes in cell number and the duration of organ growth. Ectopic expression of ARGOS prolongs the expression of AINTEGUMENTA (ANT) and CycD3;1 as well as the neoplastic activity of leaf cells. Moreover, organ enlargement in plants overexpressing ARGOS can be blocked by the loss of function of ANT, implying that ARGOS functions upstream of ANT to affect the meristematic competence of organ cells. The induction of ARGOS by auxin is attenuated or abolished in auxin-resistant1 (axr1), and overexpression of ARGOS partially restores axr1 organ development. These results suggest that ARGOS may transduce auxin signals downstream of AXR1 to regulate cell proliferation and organ growth through ANT during organogenesis.

  20. argos Is required for projection of photoreceptor axons during optic lobe development in Drosophila.

    PubMed

    Sawamoto, K; Okabe, M; Tanimura, T; Hayashi, S; Mikoshiba, K; Okano, H

    1996-02-01

    The Drosophila argos gene encodes a secreted protein with an epidermal growth factor (EGF) motif, which acts as an inhibitor of cell recruitment in the developing eye and wing. Here, we have analyzed the role of argos during optic lobe development. argos expression was observed in the optic lobes throughout the developmental stages. In argos mutants, neuropiles failed to develop normally during embryonic and larval stages, and photoreceptor axons did not project properly into the lamina. Ubiquitous expression of argos, under control of the hsp70 promoter, rescued the defects in optic lobes. We have found that glial cells failed to differentiate in the larval optic lobes of argos mutants. Correspondingly, in loss-of-function repo mutants, whose glial cells also fail to differentiate, photoreceptor axons showed the impaired projection pattern similar to the argos phenotype. These results suggest that glial cells play a role for guidance of photoreceptor axons. The loss-of-function Star mutation (StarX155) dominantly suppressed the defects in the argos optic lobes, suggesting that these two genes act in an antagonistic fashion during optic lobe development.

  1. Argos transcription is induced by the Drosophila EGF receptor pathway to form an inhibitory feedback loop.

    PubMed

    Golembo, M; Schweitzer, R; Freeman, M; Shilo, B Z

    1996-01-01

    Argos is a secreted molecule with an atypical EGF motif. It was recently shown to function as an inhibitor of the signaling triggered by the Drosophila EGF receptor (DER). In this work, we determine the contribution of Argos to the establishment of cell fates in the embryonic ventral ectoderm. Graded activation of DER is essential for patterning the ventral ectoderm. argos mutant embryos show expansion of ventral cell fates suggesting hyperactivation of the DER pathway. In the embryonic ventral ectoderm, argos is expressed in the ventralmost row of cells. We show that argos expression in the ventral ectoderm is induced by the DER pathway: argos is not expressed in DER mutant embryos, while it is ectopically expressed in the entire ventral ectoderm following ubiquitous activation of the DER pathway. argos expression appears to be triggered directly by the DER pathway, since induction can also be observed in cell culture, following activation of DER by its ligand, Spitz. Argos therefore functions in a sequential manner, to restrict the duration and level of DER signaling. This type of inhibitory feedback loop may represent a general paradigm for signaling pathways inducing diverse cell fates within a population of non-committed cells.

  2. A test bench for ARGOS: integration of sub-systems and validation of the wavefront sensing

    NASA Astrophysics Data System (ADS)

    Orban de Xivry, Gilles; Rabien, Sebastian

    2012-07-01

    ARGOS, the wide eld Laser Guide Stars adaptive optics system for the Large Binocular Telescope, is now entering its installation phase. In the meanwhile, we have started a test bench in order to integrate various Argos sub-systems and demonstrate its wavefront measurements. To this objective, we rst validate three key components of the Argos wavefront sensor which we then integrate together. The test bench therefore comprises the Argos wavefront camera system - including a large frame, fast framerate, high quantum eciency and low readout noise pnCCD -, the slope computer, and a optical gating unit. While we present here the demonstration of those three key components, it is also a step to their system level integration that enables us to validate the wavefront measurements in term of noises, timing and computation. In the near future, those system will be integrated to the wavefront sensor system of ARGOS.

  3. Merging Areas In Timber Mart South Data

    Treesearch

    Jeffrey P. Prestemon; John M. Pye

    1999-01-01

    For over twenty years, Timber Mart-South (TMS) has been distributing prices of various wood products from Southern forests. These long-term price series have been a critical resource for research into timber price and supply trends in the southern United States. Such analyses rely on consistent temporal and spatial reporting units, but these units have not always been...

  4. Altimeter and Argo float data assimilation in the Black Sea

    NASA Astrophysics Data System (ADS)

    Grayek, Sebastian; Stanev, Emil; Schulz-Stellenfleth, Johannes

    2010-05-01

    We analyse the thermo-haline characteristics in the Black Sea during the period 2002-2009 derived from numerical model simulations assimilating different observation data with the aim to improve the model skills. The Nucleus of European Modelling of the Ocean (NEMO) framework is used. In the experiment OI-1 we assimilate satellite altimetry and AVHRR data. In the experiment OI-2 we add also in-situ measurements from ARGO floats. Data assimilation uses the SESAM code and an optimal interpolation approach based on the static covariance matrix derived from the preliminary free model run, which converters the observations into basin temperature and salinity fields. Main attention in the analysis of simulations is been paid to the dominating characteristics of physical fields at seasonal and inter-annual time scales. Empirical orthogonal function (EOF) analysis of steric heights from simulations and their consistence with the ones from satellite altimetry is used to analyse the general characteristics in the thermo-haline signals. Results indicate that the free model run reproduces reasonably well the seasonal variability of Rim Current and the cold intermediate water mass formation. The assimilation of remote sensing observations only (OI-1) improves significantly the dynamics of steric heights, in particular as seen in the analysis of higher degree EOF-modes. However, in this experiment the simulation of profiles needs an improvement. This improvement is ensured by the assimilation of ARGO profiles in OI-2. However, because in the Black Sea ARGO measurements are sparse the benefit of their assimilation has to be considered carefully and is done by an objective analysis on model skills in the entire basin.

  5. ARGOS - IV. The kinematics of the Milky Way bulge

    NASA Astrophysics Data System (ADS)

    Ness, M.; Freeman, K.; Athanassoula, E.; Wylie-de-Boer, E.; Bland-Hawthorn, J.; Asplund, M.; Lewis, G. F.; Yong, D.; Lane, R. R.; Kiss, L. L.; Ibata, R.

    2013-07-01

    We present the kinematic results from our ARGOS spectroscopic survey of the Galactic bulge of the Milky Way. Our aim is to understand the formation of the Galactic bulge. We examine the kinematics of about 17 400 stars in the bulge located within 3.5 kpc of the Galactic Centre, identified from the 28 000 star ARGOS survey. We aim to determine if the formation of the bulge has been internally driven from disc instabilities as suggested by its boxy shape, or if mergers have played a significant role as expected from lambda cold dark matter simulations. From our velocity measurements across latitudes b = -5°, - 7.5° and -10° we find the bulge to be a cylindrically rotating system that transitions smoothly out into the disc. From observations of 3 fields at b = +10, the kinematics of the bulge show North-South symmetry about the major axis. Within the bulge, we find a kinematically distinct metal-poor population ([Fe/H] < -1.0) that is not rotating cylindrically. The 5 per cent of our stars with [Fe/H] < -1.0 are a slowly rotating spheroidal population, which we believe are stars of the metal-weak thick disc and halo which presently lie in the inner Galaxy. The kinematics of the two bulge components that we identified in ARGOS Paper III (mean [Fe/H] ≈ -0.25 and [Fe/H] ≈ +0.15, respectively) demonstrate that they are likely to share a common formation origin and are distinct from the more metal-poor populations of the thick disc and halo which are co-located inside the bulge. We do not exclude an underlying merger generated bulge component but our results favour bulge formation from instabilities in the early thin disc.

  6. Recent results from the ARGO-YBJ experiment

    SciTech Connect

    Camarri, P.

    2010-03-26

    The ARGO-YBJ experiment at YangBaJing in Tibet (4300 m a.s.l.) has been taking data with its full layout since October 2007. Here we present the first significant results obtained in gamma-ray astronomy and cosmic-ray physics. Emphasis is placed on the analysis of gamma-ray emission from point-like sources (Crab Nebula, MRK 421), on the preliminary limit on the antiproton/proton flux ratio, on the large-scale cosmic-ray anisotropy and on the proton-air cross section. The performance of the detector is also discussed, and the perspectives of the experiment are outlined.

  7. Recent results from the ARGO-YBJ experiment

    NASA Astrophysics Data System (ADS)

    Camarri, P.

    2010-03-01

    The ARGO-YBJ experiment at YangBaJing in Tibet (4300 m a.s.l.) has been taking data with its full layout since October 2007. Here we present the first significant results obtained in gamma-ray astronomy and cosmic-ray physics. Emphasis is placed on the analysis of gamma-ray emission from point-like sources (Crab Nebula, MRK 421), on the preliminary limit on the antiproton/proton flux ratio, on the large-scale cosmic-ray anisotropy and on the proton-air cross section. The performance of the detector is also discussed, and the perspectives of the experiment are outlined.

  8. First on-sky results with ARGOS at LBT

    NASA Astrophysics Data System (ADS)

    Orban de Xivry, G.; Rabien, S.; Busoni, L.; Gaessler, W.; Bonaglia, M.; Borelli, J.; Deysenroth, M.; Esposito, S.; Gemperlein, H.; Kulas, M.; Lefebvre, M.; Mazzoni, T.; Peter, D.; Puglisi, A.; Raab, W.; Rahmer, G.; Sivitilli, A.; Storm, J.; Ziegleder, J.

    2016-07-01

    One year and an half after ARGOS first light, the Large Binocular Telescope (LBT) laser guided ground-layer adaptive optics (GLAO) system has been operated on both sides of the LBT. The system fulfills the GLAO promise and typically delivers an improvement by a factor of 2 in FWHM over the 4'×4' field of view of both Luci instruments, the two near-infrared imagers and multi-object spectrographs. In this paper, we report on the first on-sky results and analyze the performances based on the data collected so far. We also discuss adaptive optics procedures and the joint operations with Luci for science observations.

  9. Evidence that Argos is an antagonistic ligand of the EGF receptor.

    PubMed

    Vinós, J; Freeman, M

    2000-07-20

    Argos, the inhibitor of the Drosophila epidermal growth factor (EGF) receptor, remains the only known extracellular inhibitor of this family of receptors in any organism. The functional domain of Argos includes an atypical EGF domain and it is not clear whether it binds to the EGF receptor or if it acts via a distinct receptor to reduce Egfr activity indirectly. Here we present two lines of evidence that strongly suggest that Argos directly interacts with the EGF receptor. First, Argos is unable to inhibit a chimeric receptor that contains an extracellular domain from an unrelated RTK, indicating the need for the EGF receptor extracellular domain. Second, Argos can inhibit the Drosophila EGF receptor even when expressed in human cells, implying that no other Drosophila protein is necessary for inhibition. We also report that Argos and the Drosophila activating ligand, Spitz, can influence mammalian RTK activation, albeit in a cell-type specific manner. This includes the first evidence that Argos can inhibit signalling in mammalian cells, raising the possibility of engineering an effective human EGF receptor/ErbB antagonist. Oncogene (2000) 19, 3560 - 3562

  10. Ectopic expression of a Chinese cabbage BrARGOS gene in Arabidopsis increases organ size.

    PubMed

    Wang, Bao; Zhou, Xincheng; Xu, Feng; Gao, Jianwei

    2010-06-01

    Chinese cabbage (Brassica rapa L. ssp. pekinensis) is a common and economically important crop in Asia. Specific targets of plant breeding programs for cabbage have been improvement in yield, resistance to environment stresses, and nutrition quality by means of genetic manipulation. To obtain information on yield improvement applicable for the genetic engineering approach, we have attempted to dissect the molecular pathways that regulate organ size. We first isolated a putative homolog of ARGOS full-length cDNA from Chinese cabbage leaves, which we designated BrARGOS. At the transcription level, BrARGOS was detected in all organs tested in Chinese cabbage. To test the function of this gene, we then engineered Arabidopsis plants that would overexpress BrARGOS ectopically. The organs of the transgenic Arabidopsis plants were significantly larger than those of the control plants. This increase in size was due to enhanced cell proliferation, with no contribution from cell expansion. The molecular analysis revealed that overexpression of BrARGOS up-regulated the transcription of several genes involved in the control of organ size. These results suggest that the BrARGOS gene may function as one of the regulators of organ size in Chinese cabbage. As such, manipulation of the BrARGOS gene may significantly increase the size of Chinese cabbage organs, such as Chinese cabbage heads.

  11. Service-oriented architecture for the ARGOS instrument control software

    NASA Astrophysics Data System (ADS)

    Borelli, J.; Barl, L.; Gässler, W.; Kulas, M.; Rabien, Sebastian

    2012-09-01

    The Advanced Rayleigh Guided ground layer Adaptive optic System, ARGOS, equips the Large Binocular Telescope (LBT) with a constellation of six rayleigh laser guide stars. By correcting atmospheric turbulence near the ground, the system is designed to increase the image quality of the multi-object spectrograph LUCIFER approximately by a factor of 3 over a field of 4 arc minute diameter. The control software has the critical task of orchestrating several devices, instruments, and high level services, including the already existing adaptive optic system and the telescope control software. All these components are widely distributed over the telescope, adding more complexity to the system design. The approach used by the ARGOS engineers is to write loosely coupled and distributed services under the control of different ownership systems, providing a uniform mechanism to offer, discover, interact and use these distributed capabilities. The control system counts with several finite state machines, vibration and flexure compensation loops, and safety mechanism, such as interlocks, aircraft, and satellite avoidance systems.

  12. Multifrequency seismic detectability of seasonal thermoclines assessed from ARGO data

    NASA Astrophysics Data System (ADS)

    Ker, S.; Le Gonidec, Y.; Marié, L.

    2016-08-01

    Seismic oceanography is a developing research topic where new acoustic methods allow high-resolution teledetection of the thermohaline structure of the ocean. First implementations to study the Ocean Surface Boundary Layer have recently been achieved but remain very challenging due to the weakness and shallowness of such seismic reflectors. In this article, we develop a multifrequency seismic analysis of hydrographic data sets collected in a seasonally stratified midlatitude shelf by ARGO network floats to assess the detectability issue of shallow thermoclines. This analysis, for which sensitivity to the data reduction scheme used by ARGO floats for the transmission of the profiles is discussed, allows characterizing both the depth location and the frequency dependency of the dominant reflective feature of such complex structures. This approach provides the first statistical distribution of the range of variability of the frequency-dependent seismic reflection amplitude of the midlatitude seasonal thermoclines. We introduce a new parameter to quantify the overall capability of a multichannel seismic setup, including the source strength, the fold, and the ambient noise level, to detect shallow thermoclines. Seismic source signals are approximated by Ricker wavelets, providing quantitative guidelines to help in the design of seismic experiments targeting such oceanic reflectors. For shallow midlatitude seasonal thermoclines, we show that the detectability is optimal for seismic peak frequencies between 200 and 400 Hz: this means that airgun and Sparker sources are not well suited and that significant improvements of source devices will be necessary before seismic imaging of OSBL structures can be reliably attempted.

  13. Cosmic ray physics with the ARGO-YBJ experiment

    NASA Astrophysics Data System (ADS)

    Surdo, A.; ARGO-YBJ Collaboration

    2011-04-01

    The main scientific goals of the ARGO-YBJ experiment are γ-ray astronomy with a few hundreds GeV energy threshold and cosmic ray physics below and around the knee of the primary energy spectrum (1012-1016 eV), where the transition from direct to indirect measurement techniques takes place. The ARGO-YBJ experiment, located at the Cosmic Ray Observatory of Yangbajing (Tibet, P.R. of China, 4 300 m a.s.l.), is an unconventional Extensive Air Shower array of about 6,700 m2 of active area, the only one exploiting the full-coverage technique at very high altitude currently in operation. The detector space-time granularity, performance and location offer a unique chance to make a detailed study of the structure of cosmic ray showers, in particular of the hadronic component. In this work we will focus on the main experimental results concerning cosmic ray and hadronic interaction physics: primary cosmic ray energy spectrum, antiproton over proton ratio, anisotropy in the cosmic ray flux and proton-air cross-section. Moreover, the possible data analysis improvements based on the use of all detailed information on the shower front (curvature, time width, rise time, ..), as well as the extension of the investigable energy range, allowed by the analog RPC readout, will be pointed out.

  14. Tasman Leakage of intermediate waters as inferred from Argo floats

    NASA Astrophysics Data System (ADS)

    Rosell-Fieschi, Miquel; Rintoul, Stephen R.; Gourrion, Jeröme; Pelegrí, Josep L.

    2013-10-01

    use Argo float trajectories to infer ocean current velocity at the sea surface and 1000 dbar near Australia. The East Australian Current flows southward along the east coast of Australia at both surface and intermediate levels, but only the intermediate waters leak round the southern tip of Tasmania and cross the Great Australian Bight. We calculate the transport of Antarctic Intermediate Water (AAIW) between the southern Australian coast and the Antarctic Circumpolar Current (ACC) as the velocity at 1000 dbar times the layer thickness. Between March 2006 and December 2012, the Eulerian AAIW transport through 147°E ranges between 0 and 12.0 sverdrup (Sv). The mean Tasman Leakage of intermediate waters from the Pacific Ocean into the Indian Ocean, obtained using all Argo data until March 2013, is 3.8 ± 1.3 Sv. The mean intermediate water transport into the Indian Ocean through 115°E increases to 5.2 ± 1.8 Sv due to contributions from the westward recirculation of ACC waters.

  15. Data assimilation of Argo profiles in a northwestern Pacific model

    NASA Astrophysics Data System (ADS)

    Wang, Zhaoyi; Storto, Andrea; Pinardi, Nadia; Liu, Guimei; Wang, Hui

    2017-01-01

    Based on a novel estimation of background-error covariances for assimilating Argo profiles, an oceanographic three-dimensional variational (3DVAR) data assimilation scheme was developed for the northwestern Pacific Ocean model (NwPM) for potential use in operational predictions and maritime safety applications. Temperature and salinity data extracted from Argo profiles from January to December 2010 were assimilated into the NwPM. The results show that the average daily temperature (salinity) root mean square error (RMSE) decreased from 0.99 °C (0.10 psu) to 0.62 °C (0.07 psu) in assimilation experiments throughout the northwestern Pacific, which represents a 37.2 % (27.6 %) reduction in the error. The temperature (salinity) RMSE decreased by ˜ 0.60 °C ( ˜ 0.05 psu) for the upper 900 m (1000 m). Sea level, temperature and salinity were in better agreement with in situ and satellite datasets after data assimilation than before. In addition, a 1-month experiment with daily analysis cycles and 5-day forecasts explored the performance of the system in an operational configuration. The results highlighted the positive impact of the 3DVAR initialization at all forecast ranges compared to the non-assimilative experiment. Therefore, the 3DVAR scheme proposed here, coupled to ROMS, shows a good predictive performance and can be used as an assimilation scheme for operational forecasting.

  16. Laboratory characterization of the ARGOS laser wavefront sensor

    NASA Astrophysics Data System (ADS)

    Bonaglia, Marco; Busoni, Lorenzo; Carbonaro, Luca; Quiròs Pacheco, Fernando; Xompero, Marco; Esposito, Simone; Orban de Xivry, Gilles; Rabien, Sebastian

    2012-07-01

    In this paper we present the integration status of the ARGOS wavefront sensor and the results of the closed loop tests performed in laboratory. ARGOS is the laser guide star adaptive optics system of the Large Binocular Telescope. It is designed to implement a Ground Layer Adaptive Optics correction for LUCI, an infrared imaging camera and multi-object spectrograph, using 3 pulsed Rayleigh beacons focused at 12km altitude. The WFS is configured as a Shack-Hartman sensor having a 15 x 15 subaspertures over the telescope pupil. In the WFS each LGS is independently stabilized for on-sky jitter and range-gated to reduce spot elongation. The 3 LGS are arranged on a single lenslet array and detector by the use of off-axis optics in the final part of the WFS. The units of WFS are in the integration and testing phase at Arcetri Observatory premises. We describe here the test aimed to demonstrate the functionality of the WFS in an adaptive optics closed loop performed using the internal light sources of the WFS and a MEMS deformable mirror.

  17. Molecular and Functional Characterization of Wheat ARGOS Genes Influencing Plant Growth and Stress Tolerance

    PubMed Central

    Zhao, Yue; Tian, Xuejun; Li, Yuanyuan; Zhang, Liyuan; Guan, Panfeng; Kou, Xiaoxia; Wang, Xiaobo; Xin, Mingming; Hu, Zhaorong; Yao, Yingyin; Ni, Zhongfu; Sun, Qixin; Peng, Huiru

    2017-01-01

    Auxin Regulated Gene involved in Organ Size (ARGOS) is significantly and positively associated with organ size and is involved in abiotic stress responses in plants. However, no studies on wheat ARGOS genes have been reported to date. In the present study, three TaARGOS homoeologous genes were isolated and located on chromosomes 4A, 4B, and 4D of bread wheat, all of which are highly conserved in wheat and its wild relatives. Comparisons of gene expression in different tissues demonstrated that the TaARGOSs were mainly expressed in the stem. Furthermore, the TaARGOS transcripts were significantly induced by drought, salinity, and various phytohormones. Transient expression of the TaARGOS-D protein in wheat protoplasts showed that TaARGOS-D localized to the endoplasmic reticulum. Moreover, overexpression of TaARGOS-D in Arabidopsis resulted in an enhanced germination rate, larger rosette diameter, increased rosette leaf area, and higher silique number than in wild-type (WT) plants. The roles of TaARGOS-D in the control of plant growth were further studied via RNA-seq, and it was found that 105 genes were differentially expressed; most of these genes were involved in ‘developmental processes.’ Interestingly, we also found that overexpression of TaARGOS-D in Arabidopsis improved drought and salinity tolerance and insensitivity to ABA relative to that in WT plants. Taken together, these results demonstrate that the TaARGOSs are involved in seed germination, seedling growth, and abiotic stress tolerance. PMID:28228774

  18. Multiple Aperture Radiation Therapy (MART) to Breast Cancer

    DTIC Science & Technology

    2005-11-01

    randomized clinical trial comparing total mastectomy and lumpectomy with or without irradiation in the treatment of breast cancer. New England Journal of...significantly from the conventional approach and requires considerable costs of the time and health care. The complexity of the treatment and deliver...efficient optimization method for MART inverse planning; (ii) implemented MART in a clinic environment for breast treatment ; (iii) proposed a gated IMRT/MART

  19. EPICS as a MARTe Configuration Environment

    NASA Astrophysics Data System (ADS)

    Valcarcel, Daniel F.; Barbalace, Antonio; Neto, André; Duarte, André S.; Alves, Diogo; Carvalho, Bernardo B.; Carvalho, Pedro J.; Sousa, Jorge; Fernandes, Horácio; Goncalves, Bruno; Sartori, Filippo; Manduchi, Gabriele

    2011-08-01

    The Multithreaded Application Real-Time executor (MARTe) software provides an environment for the hard real-time execution of codes while leveraging a standardized algorithm development process. The Experimental Physics and Industrial Control System (EPICS) software allows the deployment and remote monitoring of networked control systems. Channel Access (CA) is the protocol that enables the communication between EPICS distributed components. It allows to set and monitor process variables across the network belonging to different systems. The COntrol and Data Acquisition and Communication (CODAC) system for the ITER Tokamak will be EPICS based and will be used to monitor and live configure the plant controllers. The reconfiguration capability in a hard real-time system requires strict latencies from the request to the actuation and it is a key element in the design of the distributed control algorithm. Presently, MARTe and its objects are configured using a well-defined structured language. After each configuration, all objects are destroyed and the system rebuilt, following the strong hard real-time rule that a real-time system in online mode must behave in a strictly deterministic fashion. This paper presents the design and considerations to use MARTe as a plant controller and enable it to be EPICS monitorable and configurable without disturbing the execution at any time, in particular during a plasma discharge. The solutions designed for this will be presented and discussed.

  20. A comparison of Argo nominal surface and near-surface temperature for validation of AMSR-E SST

    NASA Astrophysics Data System (ADS)

    Liu, Zenghong; Chen, Xingrong; Sun, Chaohui; Wu, Xiaofen; Lu, Shaolei

    2016-06-01

    Satellite SST (sea surface temperature) from the Advanced Microwave Scanning Radiometer for the Earth Observing System (AMSR-E) is compared with in situ temperature observations from Argo profiling floats over the global oceans to evaluate the advantages of Argo NST (near-surface temperature: water temperature less than 1 m from the surface). By comparing Argo nominal surface temperature (~5 m) with its NST, a diurnal cycle caused by daytime warming and nighttime cooling was found, along with a maximum warming of 0.08±0.36°C during 14:00-15:00 local time. Further comparisons between Argo 5-m temperature/Argo NST and AMSR-E SST retrievals related to wind speed, columnar water vapor, and columnar cloud water indicate warming biases at low wind speed (<5 m/s) and columnar water vapor >28 mm during daytime. The warming tendency is more remarkable for AMSR-E SST/Argo 5-m temperature compared with AMSR-E SST/Argo NST, owing to the effect of diurnal warming. This effect of diurnal warming events should be excluded before validation for microwave SST retrievals. Both AMSR-E nighttime SST/Argo 5-m temperature and nighttime SST/Argo NST show generally good agreement, independent of wind speed and columnar water vapor. From our analysis, Argo NST data demonstrated their advantages for validation of satellite-retrieved SST.

  1. A comparison of Argo nominal surface and near-surface temperature for validation of AMSR-E SST

    NASA Astrophysics Data System (ADS)

    Liu, Zenghong; Chen, Xingrong; Sun, Chaohui; Wu, Xiaofen; Lu, Shaolei

    2017-05-01

    Satellite SST (sea surface temperature) from the Advanced Microwave Scanning Radiometer for the Earth Observing System (AMSR-E) is compared with in situ temperature observations from Argo profiling floats over the global oceans to evaluate the advantages of Argo NST (near-surface temperature: water temperature less than 1 m from the surface). By comparing Argo nominal surface temperature ( 5 m) with its NST, a diurnal cycle caused by daytime warming and nighttime cooling was found, along with a maximum warming of 0.08±0.36°C during 14:00-15:00 local time. Further comparisons between Argo 5-m temperature/Argo NST and AMSR-E SST retrievals related to wind speed, columnar water vapor, and columnar cloud water indicate warming biases at low wind speed (<5 m/s) and columnar water vapor >28 mm during daytime. The warming tendency is more remarkable for AMSR-E SST/Argo 5-m temperature compared with AMSR-E SST/Argo NST, owing to the effect of diurnal warming. This effect of diurnal warming events should be excluded before validation for microwave SST retrievals. Both AMSR-E nighttime SST/Argo 5-m temperature and nighttime SST/Argo NST show generally good agreement, independent of wind speed and columnar water vapor. From our analysis, Argo NST data demonstrated their advantages for validation of satellite-retrieved SST.

  2. Some methods of computing platform transmitter terminal location estimates. [ARGOS system; whale tracking

    NASA Technical Reports Server (NTRS)

    Hoisington, C. M.

    1984-01-01

    A position estimation algorithm was developed to track a humpback whale tagged with an ARGOS platform after a transmitter deployment failure and the whale's diving behavior precluded standard methods. The algorithm is especially useful where a transmitter location program exists; it determines the classical keplarian elements from the ARGOS spacecraft position vectors included with the probationary file messages. A minimum of three distinct messages are required. Once the spacecraft orbit is determined, the whale is located using standard least squares regression techniques. Experience suggests that in instances where circumstances inherent in the experiment yield message data unsuitable for the standard ARGOS reduction, (message data may be too sparse, span an insufficient period, or include variable-length messages). System ARGOS can still provide much valuable location information if the user is willing to accept the increased location uncertainties.

  3. Accurate estimation of influenza epidemics using Google search data via ARGO.

    PubMed

    Yang, Shihao; Santillana, Mauricio; Kou, S C

    2015-11-24

    Accurate real-time tracking of influenza outbreaks helps public health officials make timely and meaningful decisions that could save lives. We propose an influenza tracking model, ARGO (AutoRegression with GOogle search data), that uses publicly available online search data. In addition to having a rigorous statistical foundation, ARGO outperforms all previously available Google-search-based tracking models, including the latest version of Google Flu Trends, even though it uses only low-quality search data as input from publicly available Google Trends and Google Correlate websites. ARGO not only incorporates the seasonality in influenza epidemics but also captures changes in people's online search behavior over time. ARGO is also flexible, self-correcting, robust, and scalable, making it a potentially powerful tool that can be used for real-time tracking of other social events at multiple temporal and spatial resolutions.

  4. Accurate estimation of influenza epidemics using Google search data via ARGO

    PubMed Central

    Yang, Shihao; Santillana, Mauricio; Kou, S. C.

    2015-01-01

    Accurate real-time tracking of influenza outbreaks helps public health officials make timely and meaningful decisions that could save lives. We propose an influenza tracking model, ARGO (AutoRegression with GOogle search data), that uses publicly available online search data. In addition to having a rigorous statistical foundation, ARGO outperforms all previously available Google-search–based tracking models, including the latest version of Google Flu Trends, even though it uses only low-quality search data as input from publicly available Google Trends and Google Correlate websites. ARGO not only incorporates the seasonality in influenza epidemics but also captures changes in people’s online search behavior over time. ARGO is also flexible, self-correcting, robust, and scalable, making it a potentially powerful tool that can be used for real-time tracking of other social events at multiple temporal and spatial resolutions. PMID:26553980

  5. Some methods of computing platform transmitter terminal location estimates. [ARGOS system; whale tracking

    NASA Technical Reports Server (NTRS)

    Hoisington, C. M.

    1984-01-01

    A position estimation algorithm was developed to track a humpback whale tagged with an ARGOS platform after a transmitter deployment failure and the whale's diving behavior precluded standard methods. The algorithm is especially useful where a transmitter location program exists; it determines the classical keplarian elements from the ARGOS spacecraft position vectors included with the probationary file messages. A minimum of three distinct messages are required. Once the spacecraft orbit is determined, the whale is located using standard least squares regression techniques. Experience suggests that in instances where circumstances inherent in the experiment yield message data unsuitable for the standard ARGOS reduction, (message data may be too sparse, span an insufficient period, or include variable-length messages). System ARGOS can still provide much valuable location information if the user is willing to accept the increased location uncertainties.

  6. ARGO/JASON: A Remotely Operated Survey and Sampling System for Full-Ocean Depth

    DTIC Science & Technology

    1991-01-01

    three vehicles: the deep-towed imaging sled ARGO, the ROV imaging. JASON/ MEDEA is a two vehicle system that utilizes a JASON, and the sidescan sonar...Mhz bandwidth. The MEDEA /JASON Sytem The ARGO standard optical imaging package includes three real- MEDEA /JASON is a remotely operated vehicle (ROV...looking, and down-looking zoom MEDEA serving as a wide-area-survey vehicle and JASON as a views. SIT image width is approximately 1.6 times the

  7. Hints on nuclear effects from ArgoNeuT data

    SciTech Connect

    Palamara, Ornella

    2015-05-15

    Initial results from a topological analysis of CC “0 pion” muon neutrino events in LAr collected by the ArgoNeuT experiment on the NuMI LE beam at Fermilab (in the few GeV energy region) are presented and compared with predictions from MC simulations. A new analysis method, based on the reconstruction of exclusive topologies, fully exploiting the LArTPC technique capabilities, is used to analyze the events and study nuclear effects in neutrino interactions on Argon nuclei. Multiple protons accompanying the leading muon and the presence of vertex activity are clearly visible (and measured) in the events. Ratios among rates of different exclusive topologies provide indications of the size of nuclear effects in neutrino-nucleus interactions in LAr.

  8. Global interior eddy available potential energy diagnosed from Argo floats

    NASA Astrophysics Data System (ADS)

    Roullet, Guillaume; Capet, Xavier; Maze, Guillaume

    2014-03-01

    By combining all Argo profiles for the period 2002 to present, a cumulative density function is constructed on a 3-D grid of the global ocean. This function quantifies the statistics of isopycnals: time-averaged density, root-mean square of isopycnal displacement, and eddy available potential energy (EAPE). EAPE is the analogue of the eddy kinetic energy, but for the potential energy reservoir. Because it is essentially tied to the spatial structure and magnitude of mesoscale activity, EAPE is an important quantity that should be useful to evaluate eddy resolving/permitting model turbulence and circulation. Among other striking features are the turbulent behavior of Pacific and southern Atlantic Tsuchiya jets and subsurface EAPE maxima in some parts of the ocean, particularly in the Southern Ocean.

  9. Automated surface quality inspection with ARGOS: a case study

    NASA Astrophysics Data System (ADS)

    Kiefhaber, Daniel; Etzold, Fabian; Warken, Arno F.; Asfour, Jean-Michel

    2017-06-01

    The commercial availability of automated inspection systems for optical surfaces specified according to ISO 10110-7 promises unsupervised and automated quality control with reproducible results. In this study, the classification results of the ARGOS inspection system are compared to the decisions by well-trained inspectors based on manual-visual inspection. Both are found to agree in 93.6% of the studied cases. Exemplary cases with differing results are studied, and shown to be partly caused by shortcomings of the ISO 10110-7 standard, which was written for the industry standard manual-visual inspection. Applying it to high resolution images of the whole surface of objective machine vision systems brings with it a few challenges which are discussed.

  10. Consistency of Aquarius sea surface salinity with Argo products on various spatial and temporal scales

    NASA Astrophysics Data System (ADS)

    Lee, Tong

    2016-04-01

    Understanding the accuracies of satellite-derived sea surface salinity measurements in depicting temporal changes and their dependence on spatiotemporal scales is important to applications, capability assessment, and future satellite mission design. This study quantifies the consistency between Aquarius Version 4 monthly gridded sea surface salinity (SSS) with two Argo-based monthly gridded near-surface salinity products for describing temporal changes on 1° × 1°, 3° × 3°, and 10° × 10° scales. Globally averaged standard deviation values for Aquarius-Argo salinity differences on these three spatial scales are 0.16, 0.14, and 0.09 practical salinity unit (psu), compared to those between the two Argo products of 0.10, 0.09, and 0.04 psu. The consistency between Aquarius and Argo is similar to that between the two Argo products in the tropics for seasonal signals, and in the tropics and midlatitudes for nonseasonal signals. Therefore, the uncertainties of Argo products for various scales need to be considered in evaluating satellite SSS. Innovative satellite technologies are needed to improve high-latitude satellite SSS measurements.

  11. Diets of sympatric populations of American martens (Martes americana) and fishers (Martes pennanti) in California

    Treesearch

    William J. Zielinski; Neil P. Duncan

    2004-01-01

    American martens (Martes americana) and fishers (M. pennanti) occur together in mixed-conifer forests of the southern Sierra Nevada. We studied their diets in the area of sympatry by examining their feces and comparing diet diversity and overlap. Diets of both species were more diverse than previously reported in North America...

  12. Post-deployment evaluation of T-S data measured by Argo floats in the Black Sea: Regional approach

    NASA Astrophysics Data System (ADS)

    Palazov, A.; Slabakova, V.; Marinova, V.

    2012-04-01

    During the R/V "Akademik" cruise on 17-19 March 2011, a set of 3 autonomous profiling floats was successfully deployed in the Black Sea. This activity is part of the pilot BulArgo program funded by the Bulgarian National Science Fund of the Ministry of Education, Youth and Science. By BulArgo and upcoming Black Sea ARGO initiatives, a large number of T-S profiles will be collected. However, once an Argo float is launched in the sea, it is very difficult to recalibrate its sensors and to assess its drift due to the technical (moving) nature of the profilers, so Argo dataset is generally cheeked in an indirect way. Over the last years, several methods have been used for validation of Argo data, including comparison with nearby measurements of different random ARGO floats, comparison of ARGO measurement with nearby shipboard CTD data, comparison with reference climatology etc. Due to the specific hydrological regime in the Black Sea, the standard delay mode quality control procedures of Argo data has been adapted to the Black Sea regional peculiarities. The BulArgo dataset has been validated using comparison with SeaDataNet climatology and reference CTD data. The method allows detection of significant errors and deviations in the Argo dataset that can not be recognized by standard Real-Time Quality Control procedures. The BulArgo profiles has been processed in delay mode as approximately 97% of it is assessed as good data (QF 1) and less than 3% of whole dataset are flgged as suspicious or bad (QF 3 and 4). The quality controlled data have been integrated in the Bulgarian National Oceanographic Database.

  13. Bioactivities of acai (Euterpe precatoria Mart.) fruit pulp, superior antioxidant and anti-inflammatory properties to Euterpe oleracea Mart

    USDA-ARS?s Scientific Manuscript database

    There are two predominant palm tree species producing edible fruit known as “açai” found widely dispersed through the Amazon: Euterpe oleracea Mart. and Euterpe precatoria Mart. They differ from each other in terms of how the plants grow and their phytochemical composition. E. oleracea (EO) has rece...

  14. Bioactivities of acai (Euterpe precatoria mart.) fruit pulp, superior antioxidant and anti-inflammatory properties to Euterpe oleracea mart

    USDA-ARS?s Scientific Manuscript database

    There are two predominant palm tree species producing edible fruit known as "acai" found widely dispersed through the Amazon: Euterpe oleracea Mart. and Euterpe precatoria Mart. They differ from each other in terms of how the plants grow and phytochemical composition. E. oleracea (EO) has received c...

  15. Overexpression of ARGOS Genes Modifies Plant Sensitivity to Ethylene, Leading to Improved Drought Tolerance in Both Arabidopsis and Maize.

    PubMed

    Shi, Jinrui; Habben, Jeffrey E; Archibald, Rayeann L; Drummond, Bruce J; Chamberlin, Mark A; Williams, Robert W; Lafitte, H Renee; Weers, Ben P

    2015-09-01

    Lack of sufficient water is a major limiting factor to crop production worldwide, and the development of drought-tolerant germplasm is needed to improve crop productivity. The phytohormone ethylene modulates plant growth and development as well as plant response to abiotic stress. Recent research has shown that modifying ethylene biosynthesis and signaling can enhance plant drought tolerance. Here, we report novel negative regulators of ethylene signal transduction in Arabidopsis (Arabidopsis thaliana) and maize (Zea mays). These regulators are encoded by the ARGOS gene family. In Arabidopsis, overexpression of maize ARGOS1 (ZmARGOS1), ZmARGOS8, Arabidopsis ARGOS homolog ORGAN SIZE RELATED1 (AtOSR1), and AtOSR2 reduced plant sensitivity to ethylene, leading to enhanced drought tolerance. RNA profiling and genetic analysis suggested that the ZmARGOS1 transgene acts between an ethylene receptor and CONSTITUTIVE TRIPLE RESPONSE1 in the ethylene signaling pathway, affecting ethylene perception or the early stages of ethylene signaling. Overexpressed ZmARGOS1 is localized to the endoplasmic reticulum and Golgi membrane, where the ethylene receptors and the ethylene signaling protein ETHYLENE-INSENSITIVE2 and REVERSION-TO-ETHYLENE SENSITIVITY1 reside. In transgenic maize plants, overexpression of ARGOS genes also reduces ethylene sensitivity. Moreover, field testing showed that UBIQUITIN1:ZmARGOS8 maize events had a greater grain yield than nontransgenic controls under both drought stress and well-watered conditions.

  16. What can ARGO's tell us on the processes in Baltic Sea?

    NASA Astrophysics Data System (ADS)

    Roiha, Petra; Siiriä, Simo-Matti; Nummelin, Aleksi; Aro, Eemeli; Purokoski, Tero

    2014-05-01

    Finnish Meteorological Institute has been testing ARGO floats in the Baltic Sea as a mean for collecting data from the sea areas that are not easily reachable by research vessels or remote sensing. The observational data for Baltic Sea off-shore areas is very sparse and new observational methods are needed to fill the gaps in our knowledge and collect new data for different purposes, such as, operational activities, modelling and ocean science. The ARGO floats have been used successfully in the deep oceans. However, applying the ARGO floats in Baltic Sea is not straight forward, as the conditions differ greatly: the water is brackish, some areas are heavily trafficked and the northern parts freeze during the winter. In addition, the mean depth is only 54 metres, which is only a fraction of depths where ARGO floats have commonly been used. FMI has deployed three ARGO floats in Baltic Sea for different missions. The first ARGO was deployed in 2012 with normal diving algorithm, which checks the pressure hourly. The second float was modified by Aalto University so that the algorithm checks the pressure every 15 minutes. The first float was deployed in the Bothnian Sea in May 2013 and it measured over 200 profiles during its half year mission. The float with faster pressure detection was deployed in the Bothnian Sea in May 2013, and during it's 4 month mission it measured succesfully over 120 profiles. Another, longer test is ongoing on Eastern Gotland basin, where another ARGO float was deployed at Aug 2013, and still measures at Jan 2014. This one differs from earlier experiments as it has additional oxygen and scattering meters, also the area of measurements is deeper (200+ meters). The missions so far indicate, that with proper control and monitoring, ARGO's can be operated, and can measure long series of profiles. In addition to the actual measurements, the movement of ARGO floats gives possibilities to analyse currents in deeper areas of Baltic, and help

  17. An approach to predict subsurface temperature from the Argo sea surface data and its applications

    NASA Astrophysics Data System (ADS)

    Hwang, J.; Jo, Y. H.

    2016-12-01

    The mixed layer is formed by energy exchange between ocean and atmosphere. Estimating the spatio-temporal characteristics of the mixed layer depth (MLD) is very important to understand future climate changes. In general, MLD can be observed by in-situ data such as a Argo-floating. The gridded Argo field data, most widely used, has a coarse spatial resolution and uncertainty due to the horizontal gradient in the spatial density of the Argo data. On account of their high spatial and temporal resolution, satellite-derived data must be required for more precise study on the MLD. However, satellite data are limited only on surface. To overcome the limitation, the multi-linear algorithm was employed in order to predict subsurface temperature from surface data. Prior to application of satellite data, the examination of the feasibility of the approach using monthly surface and subsurface Argo data from 2005 to 2013 was conducted. Subsurface temperature anomaly (STA) at certain depths (100 m interval, from surface to 500 m) was estimated with sea surface temperature anomaly (SSTA) and dynamic height anomaly (DHA) derived from Argo data based on their linear relationship, and then the accuracy was assessed through the comparison between estimated and real subsurface Argo data. The averaged global root mean square error (RMSE) of temperature anomaly was about 0.08°C ± 0.04, and the spatial averaged bias of temperature anomaly was about 0.24 °C ± 0.13. In particular, high biases between estimated and real Argo temperature anomaly data were mainly examined in the 4 boundary regions located within the western boundary current systems (Kuroshio and Gulf Stream, Brazil-Malvinas/Falkland Confluence and Agulhas Current). In these regions, averaged temperature bias and RMSE were (0.36°C ± 0.29) and (0.12°C ± 0.06), respectively.

  18. CRAB NEBULA: FIVE-YEAR OBSERVATION WITH ARGO-YBJ

    SciTech Connect

    Bartoli, B.; Catalanotti, S.; D'Ettorre Piazzoli, B.; Di Girolamo, T.; Bernardini, P.; D'Amone, A.; De Mitri, I.; Bi, X. J.; Cao, Z.; Chen, S. Z.; Branchini, P.; Budano, A.; Camarri, P.; Cardarelli, R.; Di Sciascio, G.; Chen, T. L.; Danzengluobu; Creti, P.; Cui, S. W.; Dai, B. Z.; Collaboration: ARGO-YBJ Collaboration; and others

    2015-01-10

    The ARGO-YBJ air shower detector monitored the Crab Nebula gamma-ray emission from 2007 November to 2013 February. The integrated signal, consisting of ∼3.3 × 10{sup 5} events, reached the statistical significance of 21.1 standard deviations. The obtained energy spectrum in the energy range 0.3-20 TeV can be described by a power law function dN/dE = I {sub 0} (E/2 TeV){sup –α}, with a flux normalization I {sub 0} = (5.2 ± 0.2) × 10{sup –12} photons cm{sup –2} s{sup –1} TeV{sup –1} and α = 2.63 ± 0.05, corresponding to an integrated flux above 1 TeV of 1.97 × 10{sup –11} photons cm{sup –2} s{sup –1}. The systematic error is estimated to be less than 30% for the flux normalization and 0.06 for the spectral index. Assuming a power law spectrum with an exponential cutoff dN/dE = I {sub 0} (E/2 TeV){sup –α} exp (–E/E {sub cut}), the lower limit of the cutoff energy E {sub cut} is 12 TeV, at 90% confidence level. Our extended data set allows the study of the TeV emission over long timescales. Over five years, the light curve of the Crab Nebula in 200-day bins is compatible with a steady emission with a probability of 7.3 × 10{sup –2}. A correlated analysis with Fermi-LAT data over ∼4.5 yr using the light curves of the two experiments gives a Pearson correlation coefficient r = 0.56 ± 0.22. Concerning flux variations on timescales of days, a ''blind'' search for flares with a duration of 1-15 days gives no excess with a significance higher than four standard deviations. The average rate measured by ARGO-YBJ during the three most powerful flares detected by Fermi-LAT is 205 ± 91 photons day{sup –1}, consistent with the average value of 137 ± 10 day{sup –1}.

  19. Crab Nebula: Five-year Observation with ARGO-YBJ

    NASA Astrophysics Data System (ADS)

    Bartoli, B.; Bernardini, P.; Bi, X. J.; Branchini, P.; Budano, A.; Camarri, P.; Cao, Z.; Cardarelli, R.; Catalanotti, S.; Chen, S. Z.; Chen, T. L.; Creti, P.; Cui, S. W.; Dai, B. Z.; D'Amone, A.; Danzengluobu; De Mitri, I.; D'Ettorre Piazzoli, B.; Di Girolamo, T.; Di Sciascio, G.; Feng, C. F.; Feng, Zhaoyang; Feng, Zhenyong; Gou, Q. B.; Guo, Y. Q.; He, H. H.; Hu, Haibing; Hu, Hongbo; Iacovacci, M.; Iuppa, R.; Jia, H. Y.; Labaciren; Li, H. J.; Liguori, G.; Liu, C.; Liu, J.; Liu, M. Y.; Lu, H.; Ma, L. L.; Ma, X. H.; Mancarella, G.; Mari, S. M.; Marsella, G.; Martello, D.; Mastroianni, S.; Montini, P.; Ning, C. C.; Panareo, M.; Perrone, L.; Pistilli, P.; Ruggieri, F.; Salvini, P.; Santonico, R.; Shen, P. R.; Sheng, X. D.; Shi, F.; Surdo, A.; Tan, Y. H.; Vallania, P.; Vernetto, S.; Vigorito, C.; Wang, H.; Wu, C. Y.; Wu, H. R.; Xue, L.; Yang, Q. Y.; Yang, X. C.; Yao, Z. G.; Yuan, A. F.; Zha, M.; Zhang, H. M.; Zhang, L.; Zhang, X. Y.; Zhang, Y.; Zhao, J.; Zhaxiciren; Zhaxisangzhu; Zhou, X. X.; Zhu, F. R.; Zhu, Q. Q.; Zizzi, G.; ARGO-YBJ Collaboration; Striani, E.

    2015-01-01

    The ARGO-YBJ air shower detector monitored the Crab Nebula gamma-ray emission from 2007 November to 2013 February. The integrated signal, consisting of ~3.3 × 105 events, reached the statistical significance of 21.1 standard deviations. The obtained energy spectrum in the energy range 0.3-20 TeV can be described by a power law function dN/dE = I 0 (E/2 TeV)-α, with a flux normalization I 0 = (5.2 ± 0.2) × 10-12 photons cm-2 s-1 TeV-1 and α = 2.63 ± 0.05, corresponding to an integrated flux above 1 TeV of 1.97 × 10-11 photons cm-2 s-1. The systematic error is estimated to be less than 30% for the flux normalization and 0.06 for the spectral index. Assuming a power law spectrum with an exponential cutoff dN/dE = I 0 (E/2 TeV)-α exp (-E/E cut), the lower limit of the cutoff energy E cut is 12 TeV, at 90% confidence level. Our extended data set allows the study of the TeV emission over long timescales. Over five years, the light curve of the Crab Nebula in 200-day bins is compatible with a steady emission with a probability of 7.3 × 10-2. A correlated analysis with Fermi-LAT data over ~4.5 yr using the light curves of the two experiments gives a Pearson correlation coefficient r = 0.56 ± 0.22. Concerning flux variations on timescales of days, a "blind" search for flares with a duration of 1-15 days gives no excess with a significance higher than four standard deviations. The average rate measured by ARGO-YBJ during the three most powerful flares detected by Fermi-LAT is 205 ± 91 photons day-1, consistent with the average value of 137 ± 10 day-1.

  20. Polychlorinated biphenyls in a terrestrial predator, the pine marten (Martes martes L.)

    SciTech Connect

    Bremle, G.; Larsson, P.; Helldin, J.O.

    1997-09-01

    A terrestrial predator population, the pine marten (Martes martes, L.), inhabiting an area in mid-Sweden was investigated for polychlorinated biphenyls, p,p{prime}-DDE, lindane, and hexachlorobenzene. The condition of the animals, as shown by intestine fat amounts or fat content of muscle tissue, showed negative relationships with concentration of persistent pollutants. The relationship resulted in a higher concentration of pollutants as intestinal fat amounts of muscle fat content decreased and lower levels of pollutants as these indexes of condition improved. The results indicate that terrestrial predators show changes in pollutant concentration due to condition, caused by food availability and starvation. No differences in pollutant concentration were recorded between males and females and no relationship was found for levels of pollutants and age or reproduction (females). The latter results are in contrast to those found for aquatic predatory mammals.

  1. [Genetic analysis of sympatric sable (Martes zibellina) and Marten (M. martes) populations in the northern urals].

    PubMed

    Rozhnov, V V; Meshcherskiĭ, I G; Pishchulina, S L; Simakin, L V

    2010-04-01

    Analysis of nucleotide sequences of the mitochondrial DNA (mtDNA) control region (495 bp) of sables (Martes zibellina) and martens (M. martes) from allopatric parts of the species ranges has shown a considerable interspecific genetic distance (3%). In sympatric populations of these species in the northern Urals, differences between two species-specific mtDNA lineages are still large; however, classification of each individual nucleotide sequence with one of the two lineages is not correlated with whether the given animal is phenotypically a sable, a marten, or a potential hybrid (the so-called kidas). This indicates a high degree of mutual introgression of the sable and marten mtDNAs in the northern Urals and suggests that their interspecific hybridization is common in the sympatric zone.

  2. [Analyzing spatial-temporal dynamics of the ecological niche: a marten (Martes martes) population case study].

    PubMed

    Puzachenko, Iu G; Zheltukhin, A S; Sandlerskiĭ, R B

    2010-01-01

    A potential of discriminant analysis is demonstrated in a case study of the common marten (Martes martes L., 1758) ecological niche within the Central Forest Reserve and its buffer zone. The analysis is aimed at identifying how the probability to encounter a marten's footprint along a walking route depends on the relief and other parameters of the environment discerned by remote sensing. The analyses that were done individually for each of the eleven months from a three-year observation period have revealed the pattern of the species spatial distribution and a measure of its association with the environment to be dependent, to a large extent, on the weather conditions. In general, associations with the environment do increase under unfavorable conditions. The methods are suggested that integrate outcomes of the monthly analyses into a general map of habitat types. The technique presented has wide application opportunities in studying the ecology of populations and solving problems of practical ecology.

  3. Accuracy of ARGOS locations of Pinnipeds at-sea estimated using Fastloc GPS.

    PubMed

    Costa, Daniel P; Robinson, Patrick W; Arnould, John P Y; Harrison, Autumn-Lynn; Simmons, Samantha E; Hassrick, Jason L; Hoskins, Andrew J; Kirkman, Stephen P; Oosthuizen, Herman; Villegas-Amtmann, Stella; Crocker, Daniel E

    2010-01-15

    ARGOS satellite telemetry is one of the most widely used methods to track the movements of free-ranging marine and terrestrial animals and is fundamental to studies of foraging ecology, migratory behavior and habitat-use. ARGOS location estimates do not include complete error estimations, and for many marine organisms, the most commonly acquired locations (Location Class 0, A, B, or Z) are provided with no declared error estimate. We compared the accuracy of ARGOS Locations to those obtained using Fastloc GPS from the same electronic tags on five species of pinnipeds: 9 California sea lions (Zalophus californianus), 4 Galapagos sea lions (Zalophus wollebaeki), 6 Cape fur seals (Arctocephalus pusillus pusillus), 3 Australian fur seals (A. p. doriferus) and 5 northern elephant seals (Mirounga angustirostris). These species encompass a range of marine habitats (highly pelagic vs coastal), diving behaviors (mean dive durations 2-21 min) and range of latitudes (equator to temperate). A total of 7,318 ARGOS positions and 27,046 GPS positions were collected. Of these, 1,105 ARGOS positions were obtained within five minutes of a GPS position and were used for comparison. The 68(th) percentile ARGOS location errors as measured in this study were LC-3 0.49 km, LC-2 1.01 km, LC-1 1.20 km, LC-0 4.18 km, LC-A 6.19 km, LC-B 10.28 km. The ARGOS errors measured here are greater than those provided by ARGOS, but within the range of other studies. The error was non-normally distributed with each LC highly right-skewed. Locations of species that make short duration dives and spend extended periods on the surface (sea lions and fur seals) had less error than species like elephant seals that spend more time underwater and have shorter surface intervals. Supplemental data (S1) are provided allowing the creation of density distributions that can be used in a variety of filtering algorithms to improve the quality of ARGOS tracking data.

  4. Accuracy of ARGOS Locations of Pinnipeds at-Sea Estimated Using Fastloc GPS

    PubMed Central

    Costa, Daniel P.; Robinson, Patrick W.; Arnould, John P. Y.; Harrison, Autumn-Lynn; Simmons, Samantha E.; Hassrick, Jason L.; Hoskins, Andrew J.; Kirkman, Stephen P.; Oosthuizen, Herman; Villegas-Amtmann, Stella; Crocker, Daniel E.

    2010-01-01

    Background ARGOS satellite telemetry is one of the most widely used methods to track the movements of free-ranging marine and terrestrial animals and is fundamental to studies of foraging ecology, migratory behavior and habitat-use. ARGOS location estimates do not include complete error estimations, and for many marine organisms, the most commonly acquired locations (Location Class 0, A, B, or Z) are provided with no declared error estimate. Methodology/Principal Findings We compared the accuracy of ARGOS locations to those obtained using Fastloc GPS from the same electronic tags on five species of pinnipeds: 9 California sea lions (Zalophus californianus), 4 Galapagos sea lions (Zalophus wollebaeki), 6 Cape fur seals (Arctocephalus pusillus pusillus), 3 Australian fur seals (A. p. doriferus) and 5 northern elephant seals (Mirounga angustirostris). These species encompass a range of marine habitats (highly pelagic vs coastal), diving behaviors (mean dive durations 2–21 min) and range of latitudes (equator to temperate). A total of 7,318 ARGOS positions and 27,046 GPS positions were collected. Of these, 1,105 ARGOS positions were obtained within five minutes of a GPS position and were used for comparison. The 68th percentile ARGOS location errors as measured in this study were LC-3 0.49 km, LC-2 1.01 km, LC-1 1.20 km, LC-0 4.18 km, LC-A 6.19 km, LC-B 10.28 km. Conclusions/Significance The ARGOS errors measured here are greater than those provided by ARGOS, but within the range of other studies. The error was non-normally distributed with each LC highly right-skewed. Locations of species that make short duration dives and spend extended periods on the surface (sea lions and fur seals) had less error than species like elephant seals that spend more time underwater and have shorter surface intervals. Supplemental data (S1) are provided allowing the creation of density distributions that can be used in a variety of filtering algorithms to improve the quality of ARGOS

  5. Metals removal from an acid mine drainage: The Argo Tunnel experience

    SciTech Connect

    Cevaal, J.N.; Abel, R.J.; Rogers, S.E.

    1996-12-31

    The abandoned Argo Tunnel, located approximately 30 miles west of Denver in Idaho Springs, Colorado, is part of the Clear Creek/Central City Superfund Site and was identified as the most significant source of metals contamination to Clear Creek. More than 740 pounds of metals (including iron, manganese, zinc, copper and aluminum) are discharged from the Argo each day. During the course of bench-scale testing and preliminary design of the chemical precipitation treatment facility for the Argo Tunnel acid mine drainage, three treatment processes: conventional chemical precipitation, {open_quotes}high density sludge{close_quotes} precipitation arid membrane separation; and four chemical reagents: hydrated lime, caustic, magnesium hydroxide, and lime plus soda ash were evaluated. The result was the prepurchase of a {open_quotes}high density sludge{close_quotes} precipitation process using caustic as the reagent. The process was sized to treat the design average flow rate from the tunnel with additional capacity for potential future groundwater flows and for most surge events. The treatment facility was sited at the Argo Tunnel portal and adjacent to the Argo Mill, which is listed on the National Register of Historic Places. The nearby historic designation and strong local mining heritage led to null styled superstructure encompassing indigenous mining architecture. Improvements to the water quality within the basin include removal of most of the 740 pounds of metals the tunnel currently discharges to Clear Creek and a significant reduction in instream metal concentrations, notably zinc, manganese and copper.

  6. Instrument control software development process for the multi-star AO system ARGOS

    NASA Astrophysics Data System (ADS)

    Kulas, M.; Barl, L.; Borelli, J. L.; Gässler, W.; Rabien, S.

    2012-09-01

    The ARGOS project (Advanced Rayleigh guided Ground layer adaptive Optics System) will upgrade the Large Binocular Telescope (LBT) with an AO System consisting of six Rayleigh laser guide stars. This adaptive optics system integrates several control loops and many different components like lasers, calibration swing arms and slope computers that are dispersed throughout the telescope. The purpose of the instrument control software (ICS) is running this AO system and providing convenient client interfaces to the instruments and the control loops. The challenges for the ARGOS ICS are the development of a distributed and safety-critical software system with no defects in a short time, the creation of huge and complex software programs with a maintainable code base, the delivery of software components with the desired functionality and the support of geographically distributed project partners. To tackle these difficult tasks, the ARGOS software engineers reuse existing software like the novel middleware from LINC-NIRVANA, an instrument for the LBT, provide many tests at different functional levels like unit tests and regression tests, agree about code and architecture style and deliver software incrementally while closely collaborating with the project partners. Many ARGOS ICS components are already successfully in use in the laboratories for testing ARGOS control loops.

  7. Status of ARGOS - The Laser Guide Star System for the LBT

    NASA Astrophysics Data System (ADS)

    Raab, Walfried; Rabien, Sebastian; Gaessler, Wolfgang; Esposito, Simone; Antichi, Jacopo; Lloyd-Hart, Michael; Barl, Lothar; Beckmann, Udo; Bonaglia, Marco; Borelli, Jose; Brynnel, Joar; Buschkamp, Peter; Busoni, Lorenzo; Carbonaro, Luca; Christou, Julian; Connot, Claus; Davies, Richard; Deysenroth, Matthias; Durney, Olivier; Green, Richard; Gemperlein, Hans; Gasho, Victor; Haug, Marcus; Hubbard, Pete; Ihle, Sebastian; Kulas, Martin; Loose, Christina; Lehmitz, Michael; Noenickx, Jamison; Nussbaum, Edmund; Orban De Xivry, Gilles; Quirrenbach, Andreas; Peter, Diethard; Rahmer, Gustavo; Rademacher, Matt; Storm, Jesper; Schwab, Christian; Vaitheeswaran, Vidhya; Ziegleder, Julian

    2013-12-01

    ARGOS is an innovative multiple laser guide star adaptive optics system for the Large Binocular Telescope (LBT), designed to perform effective GLAO correction over a very wide field of view. The system is using high powered pulsed green (532 nm) lasers to generate a set of three guide stars above each of the LBT mirrors. The laser beams are launched through a 40 cm telescope and focused at an altitude of 12 km, creating laser beacons by means of Rayleigh scattering. The returning scattered light, primarily sensitive to the turbulences close to the ground, is detected by a gated wavefront sensor system. The derived ground layer correction signals are directly driving the adaptive secondary mirror of the LBT. ARGOS is especially designed for operation with the multiple object spectrograph Luci, which will benefit from both, the improved spatial resolution, as well as the strongly enhanced flux. In addition to the GLAO Rayleigh beacon system, ARGOS was also designed for a possible future upgrade with a hybrid sodium laser - Rayleigh beacon combination, enabling diffraction limited operation. The ARGOS laser system has undergone extensive tests during Summer 2012 and is scheduled for installation at the LBT in Spring 2013. The remaining sub-systems will be installed during the course of 2013. We report on the overall status of the ARGOS system and the results of the sub-system characterizations carried out so far.

  8. Mutations modulating the Argos-regulated signaling pathway in Drosophila eye development.

    PubMed

    Taguchi, A; Sawamoto, K; Okano, H

    2000-04-01

    Argos is a secreted protein that contains an EGF-like domain and acts as an inhibitor of Drosophila EGF receptor activation. To identify genes that function in the Argos-regulated signaling pathway, we performed a genetic screen for enhancers and suppressors of the eye phenotype caused by the overexpression of argos. As a result, new alleles of known genes encoding components of the EGF receptor pathway, such as Star, sprouty, bulge, and clown, were isolated. To study the role of clown in development, we examined the eye and wing phenotypes of the clown mutants in detail. In the eye discs of clown mutants, the pattern of neuronal differentiation was impaired, showing a phenotype similar to those caused by a gain-of-function EGF receptor mutation and overexpression of secreted Spitz, an activating ligand for the EGF receptor. There was also an increased number of pigment cells in the clown eyes. Epistatic analysis placed clown between argos and Ras1. In addition, we found that clown negatively regulated the development of wing veins. These results suggest that the clown gene product is important for the Argos-mediated inhibition of EGF receptor activation during the development of various tissues. In addition to the known genes, we identified six mutations of novel genes. Genetic characterization of these mutants suggested that they have distinct roles in cell differentiation and/or survival regulated by the EGF receptor pathway.

  9. Evaluation of the Argo network using statistical space-time scales derived from satellite altimetry data

    NASA Astrophysics Data System (ADS)

    Kuragano, Tsurane; Fujii, Yosuke; Kamachi, Masafumi

    2015-06-01

    This study evaluates capability of the Argo observation network for monitoring ocean variation, especially for eddy-scale variation, by using an optimum interpolation (OI) procedure. Sea surface dynamic height anomalies (DHAs) are derived from Argo temperature and salinity profile data, and DHA fields are obtained by the OI based on the space-time correlation scales estimated from along-track sea level anomaly (SLA) data by satellite altimetry. The DHA fields are compared with the SLA fields derived from the same OI applied to the along-track SLA data. The results show that the equatorial Kelvin waves and tropical instability waves are well captured by Argo floats. Eddies are also monitored effectively in the subtropical western North Pacific. The OI results of DHA do not agree well with those of SLA in the high latitudes. A simple test of the space-time OI analysis shows that more than six data in the e-folding domain, where the correlation coefficient of ocean variation is above e-1, are required for the reliable analysis with 99% confidence level. Argo floats provide sufficient number of observations for the reliable analysis in the low latitudes and some areas in the North Pacific. Two to three times more Argo data would be required in most of midlatitudes and much more in high latitudes for capturing eddy-scale variation.

  10. In vivo analysis of Argos structure-function. Sequence requirements for inhibition of the Drosophila epidermal growth factor receptor.

    PubMed

    Howes, R; Wasserman, J D; Freeman, M

    1998-02-13

    The Drosophila Argos protein is the only known extracellular inhibitor of the epidermal growth factor receptor (EGFR). It is structurally related to the activating ligands, in that it is a secreted protein with a single epidermal growth factor (EGF) domain. To understand the mechanism of Argos inhibition, we have investigated which regions of the protein are essential. A series of deletions were made and tested in vivo; furthermore, by analyzing chimeric proteins between Argos and the activating ligand, Spitz (a transforming growth factor-alpha-like factor), we have examined what makes one inhibitory and the other activating. Our results reveal that Argos has structural requirements that differ from all known EGFR activating ligands; domains flanking the EGF domain are essential for its function. We have also defined the important regions of the atypical Argos EGF domain. The extended B-loop is necessary, whereas the C-loop can be replaced with the equivalent Spitz region without substantially affecting Argos function. Comparison of the argos genes from Drosophila melanogaster and the housefly, Musca domestica, supports our structure-function analysis. These studies are a prerequisite for understanding how Argos inhibits the Drosophila EGFR and provide a basis for designing mammalian EGFR inhibitors.

  11. Project ARGO: Gas phase formation in simulated microgravity

    NASA Technical Reports Server (NTRS)

    Powell, Michael R.; Waligora, James M.; Norfleet, William T.; Kumar, K. Vasantha

    1993-01-01

    The ARGO study investigated the reduced incidence of joint pain decompression sickness (DCS) encountered in microgravity as compared with an expected incidence of joint pain DCS experienced by test subjects in Earth-based laboratories (unit gravity) with similar protocols. Individuals who are decompressed from saturated conditions usually acquire joint pain DCS in the lower extremities. Our hypothesis is that the incidence of joint pain DCS can be limited by a significant reduction in the tissue gas micronuclei formed by stress-assisted nucleation. Reductions in dynamic and kinetic stresses in vivo are linked to hypokinetic and adynamic conditions of individuals in zero g. We employed the Doppler ultrasound bubble detection technique in simulated microgravity studies to determine quantitatively the degree of gas phase formation in the upper and lower extremities of test subjects during decompression. We found no evidence of right-to-left shunting through pulmonary vasculature. The volume of gas bubble following decompression was examined and compared with the number following saline contrast injection. From this, we predict a reduced incidence of DCS on orbit, although the incidence of predicted mild DCS still remains larger than that encountered on orbit.

  12. ARGOS: a laser star constellation for the LBT

    NASA Astrophysics Data System (ADS)

    Kanneganti, Shrikrishna; Rabien, Sebastian; Deysenroth, Matthias; Ziegleder, Julian; Gemperlein, Hans; Haug, Marcus

    2010-07-01

    ARGOS is an innovative multi-star adaptive optics system being built for use with LUCIFER on the Large Binocular Telescope (LBT). LUCIFER is a wide field imager and multi-object spectrograph. Using a constellation of laser guide stars permits PSF correction over a wide field in exchange for a relatively small sacrifice in achievable correction. The laser constellation consists of three stars per each of the two eyes of the LBT. The stars are nominally positioned on a circle 2' in radius, but each star can be moved by upto 0.5' in any direction. Nd:YAG (SHG) lasers from InnoLas Laser GmbH are used to create the green (532nm) laser stars, and have an output above 18 W each at the planned pulsing frequency of 10kHz. The lasers are launched using a 40cm telescope and focused at a height of 12 km. The laser system is designed to be optically simple yet configurable. It also provisions for a central sodium laser to be installed later. We detail the characteristics of the laser system and the current state of its development.

  13. Observations of Bacterial Behavior during Infection Using the ARGOS Method

    NASA Astrophysics Data System (ADS)

    Charest, A. J.; Algarni, S.; Iannacchione, G. S.

    2015-03-01

    This research employed the Area Recorded Generalized Optical Scattering (ARGOS) approach which allowed for the observation of bacterial changes in terms of individual particles and population dynamics in real time. This new approach allows for an aqueous environment to be manipulated while conducting time-specific measurements over an indefinite amount of time. This current study provides a more time-specific method in which the bacteria remained within the initial conditions and allows for more time precision than provided by analyzing concentrations of plaque-forming units (PFU). This study involved the bacteria (F-amp) during infection by bacteriophage (MS2). The relative total intensity allows for detailed measurements of the bacteria population over time. The bacteria characteristics were also evaluated such as the root mean square image difference (at specific wavevectors), fractal dimension and effective radius. The growth rate of the infected bacteria occurred at a rate higher than the uninfected bacteria similarly, the death rates were also higher for the infected bacteria than the uninfected bacteria. The present study indicates that bacteria may react to infection by increasing the rate of population growth.

  14. Cosmic ray physics with the ARGO-YBJ experiment

    NASA Astrophysics Data System (ADS)

    de Mitri, Ivan; ARGO-YBJ Collaboration

    2011-02-01

    Cosmic ray physics in the 1012-1015 eV primary energy range is among the main scientific goals of the ARGO-YBJ experiment. The detector, located at the Cosmic Ray Observatory of Yangbajing (Tibet, P.R. China) at 4300 m a.s.l., is a full coverage Extensive Air Shower array consisting of a carpet of Resistive Plate Chambers of about 6000 m2. The apparatus layout, performance and location offer a unique possibility to make a deep study of several characteristics of the hadronic component of the cosmic ray flux in an energy window marked by the transition from direct to indirect measurements. In this work we will focus on the experimental results concerning the measurements of the primary cosmic ray energy spectrum and of the proton-air cross-section. The all-particle spectrum has been measured, by using a bayesian unfolding technique, in the 1-100 TeV energy region. The proton-air cross-section has been measured at the same energies, by exploiting the cosmic ray flux attenuation for different atmospheric depths (i.e. zenith angles). The total proton-proton cross-section has then been estimated at center of mass energies between 70 and 500 GeV, where no accelerator data are currently available.

  15. Proposed gas release experiment on the argos satellite. Interim report

    SciTech Connect

    Lai, S.T.; Murad, E.; Pike, C.P.

    1992-01-29

    We propose to release xenon and carbon dioxide gases from nozzles on the Advanced Research and Global Observation Satellite (ARGOS) satellite orbiting with a velocity of about 7.4 km/s at an altitude of about 800 km. The releases will be conducted mostly in darkness over the Maui telescope site. The vector sum of the satellite and gas velocities will exceed the velocity requirement for the critical ionization velocity (CIV) process of xenon. It is feasible that the xenon gas will achieve critical velocity ionization. Associative ionization and collisional stripping will not occur for the xenon gas and there is no photo-ionization in darkness; ionization processes competing with CIV are absent. Neutral density, ambient magnetic field, and seed ionization effects on the xenon gas CIV will be discussed. Unlike xenon, carbon dioxide will not undergo CIV because of its higher velocity requirement. However, it is feasible that carbon dioxide colliding with the atmospheric species will form excited CO and OH molecules, which will radiate subsequently. Optical, IR, and UV observations on the satellite and at Maui will provide diagnostic measurements for the experiment.

  16. Synthesis of the 18th ArgoSpine Symposium.

    PubMed

    Kehr, P; Graftiaux, A; Mazel, C; Richard, N

    2014-07-01

    The subject of this 18th Symposium of ArgoSpine Association was the space of the intervertebral discs. Space of the intervertebral discs must be initially defined anatomically and histologically. A geometrical rebuilding in 3D is possible and must allow a modeling of the intervertebral discs. The physiology of the disc, its nutrition, must be known, in particular that of the center of the disc. The disc constitutes the base of the balance of the rachis, balances which can be only dynamic. The degenerative cascade by the loss of the proteoglycans involves the loss of the biomechanical properties of the disc. The consequences of this degenerative cascade are the base of all the vertebral pathology of origin of the intervertebral discs and even of the posterior articular facets. The origin of the pains and the diagnosis, especially at the lumbar level, are studied by the speakers. Traumatology of the intervertebral discs is the object of a particular chapter. Finally, the average therapeutic ones, that is, decompression of the intervertebral discs, fusion of the intervertebral discs, the recovery of mobility of the intervertebral discs, and the capacity of restoration of space of the intervertebral discs, are studied in detail. The infection of the disc is studied in detail.

  17. Status of LHAASO updates from ARGO-YBJ

    NASA Astrophysics Data System (ADS)

    Cao, Zhen

    2014-04-01

    The Large High Altitude Air Shower Observatory (LHAASO) is a multipurpose project with a complex detector array for high energy gamma ray and cosmic ray detection. The array of 1 km2 is composed of five types of detectors to measure shower arrival direction, total number of secondary particles, muon content, Cherenkov image and high energy gamma rays near shower core, respectively. The main scientific goals are (1) searching for galactic cosmic ray origins by extensive spectroscopy investigations of gamma ray sources above 30 TeV; (2) all sky survey for gamma ray sources at energies higher than 300 GeV; (3) energy spectrum and composition measurements of cosmic rays over a wide range covering knees with fixed energy scale and known fluxes for all species at the low energy end. In this paper, the progress on relevant detector developments is reported, including constructions of prototype detectors at Tibet site and coincidence operation with the ARGO-YBJ resistive plat chamber full coverage array at 4300 m a.s.l. The energy spectrum of cosmic ray hydrogen and Helium nuclei up to 0.8 PeV is reported as the first piece of physics measurements by the LHAASO experiment.

  18. Prenatal development in fishers (Martes pennanti)

    USGS Publications Warehouse

    Frost, H.C.; Krohn, W.B.; Bezembluk, E.A.; Lott, R.; Wallace, C.R.

    2005-01-01

    We evaluated and quantified prenatal growth of fishers (Martes pennanti) using ultrasonography. Seven females gave birth to 21 kits. The first identifiable embryonic structures were seen 42 d prepartum; these appeared to be unimplanted blastocysts or gestational sacs, which subsequently implanted in the uterine horns. Maternal and fetal heart rates were monitored from first detection to birth. Maternal heart rates did not differ among sampling periods, while fetal hearts rates increased from first detection to birth. Head and body differentiation, visible limbs and skeletal ossification were visible by 30, 23 and 21 d prepartum, respectively. Mean diameter of gestational sacs and crown-rump lengths were linearly related to gestational age (P < 0.001). Biparietal and body diameters were also linearly related to gestational age (P < 0.001) and correctly predicted parturition dates within 1-2 d. ?? 2004 Elsevier Inc. All rights reserved.

  19. The ARGO-YBJ legacy to next generation wide field-of-view experiments

    NASA Astrophysics Data System (ADS)

    Di Sciascio, Giuseppe

    2017-06-01

    The ARGO-YBJ experiment has been in stable data taking for more than 5 years at the YangBaJing Cosmic Ray Observatory (Tibet, P.R. China, 4300 m a.s.l., 606 g/cm2). With a duty-cycle greater than 86% the detector collected about 5×1011 events in a wide energy range, from few hundreds GeV up to about 10 PeV. High altitude location and detector features make ARGO-YBJ capable of investigating a wide range of important issues in Cosmic Ray and Astroparticle Physics by imaging the front of atmospheric showers with unprecedented resolution and detail. In this contribution some of the latest physics results obtained by ARGO-YBJ in gamma-ray astronomy and in cosmic ray physics are summarized. The prospects of TeV gamma-ray observations with new ground-based wide field-of-view detectors are presented.

  20. Search for High-Energy Emission from GRBs with the ARGO-YBJ Detector

    NASA Astrophysics Data System (ADS)

    di Girolamo, T.

    2009-05-01

    ARGO-YBJ is a ``full coverage'' air shower detector consisting of a 6700 m2 carpet of Resistive Plate Counters, located at Yangbajing (Tibet, P.R. China, 4300 m a.s.l). Its large field of view (~2 sr, limited only by the atmospheric absorption) and high duty-cycle make ARGO-YBJ particularly suitable to detect unpredictable and short duration events such as GRBs. ARGO-YBJ works using two techniques: the ``Scaler Mode,'' which reaches the lower energy limit (~1 GeV) of the detector, and the ``Shower Mode,'' with an energy threshold of a few hundreds of GeV. Here we present the results of the search for high-energy emission from GRBs in coincidence with satellite detections.

  1. Convective structures in the Lofoten Basin based on satellite and Argo data

    NASA Astrophysics Data System (ADS)

    Alexeev, V. A.; Ivanov, V. V.; Repina, I. A.; Lavrova, O. Yu.; Stanichny, S. V.

    2016-12-01

    We discuss the possibility of detecting deep convection in the Lofoten Basin of the Norwegian Sea based on the eddy structures revealed from the satellite data. Satellite altimetry, SAR imagery, and MODIS satellite spectral radiometer sea-surface temperature (SST) data are used in the analysis, along with the data of oceanographic Argo floats. It is shown that the eddies identified from the satellite data correspond to the convective cells in the same region according to the data of the Argo floats. We consider several examples of the summer eddy and one winter eddy and the corresponding structures in the ocean measured by the Argo floats when they were located close to the identified eddies. As this method develops and improves, it can be used for the analysis of the dynamic of oceanic eddies in the region of the Lofoten Basin, and possibly in other regions with active deep convection.

  2. Biogeochemical-Argo: achievements, challenges for the future and potential synergies with other components of ocean observation systems

    NASA Astrophysics Data System (ADS)

    Claustre, Hervé; Johnson, Ken

    2017-04-01

    The recently launched Biogeochemical-Argo (BGC-Argo) program aims at developing a global network of biogeochemical sensors on Argo profiling floats for acquiring long-term high-quality time-series of oceanic properties. BGC-Argo is in particular poised to address a number of challenges in ocean science (e.g. hypoxia, carbon uptake, ocean acidification, biological-carbon pump and phytoplankton communities), topics that are difficult, if not impossible, to address with our present observing assets. Presently six variables are considered as core BGC-Argo variables (O2, NO3, pH, Chla, suspended particles and downwelling irradiance). Historically, BGC-Argo has been initiated through small-scale "showcase" projects progressively scaling up into regional case studies essentially addressing key biological pump-related questions in specific regions (e.g. sub-tropical gyres, North Atlantic, Southern Ocean). Now BGC-Argo is transitioning towards a global and sustained observation system thanks to progressive international coordination of national contributions and to increasingly mature and efficient data management and distribution systems. In this presentation, we will highlight a variety of results derived from BGC-Argo observations and encompassing a wide range of topics related to ocean biogeochemistry. Challenges for the future and long-term sustainability of the system will be addressed in particular with respect to maintaining a high-quality and interoperable dataset over long-term. Part of this can be achieved through a tight interaction with programs (e.g. GOSHIP) and their historical databases, which should constitute a corner stone to assess data quality. Example on the interplay between BGC-Argo and GlodapV2 databases will be particularly exemplified in this context. Furthermore, we will illustrate the potential synergies between synoptically measured surface satellite-quantities and their vertically resolved (BGC-Argo) counterparts into the development of 3D

  3. On the mesoscale monitoring capability of Argo floats in the Mediterranean Sea

    NASA Astrophysics Data System (ADS)

    Sánchez-Román, Antonio; Ruiz, Simón; Pascual, Ananda; Mourre, Baptiste; Guinehut, Stéphanie

    2017-03-01

    In this work a simplified observing system simulation experiment (OSSE) approach is used to investigate which Argo design sampling in the Mediterranean Sea would be necessary to properly capture the mesoscale dynamics in this basin. The monitoring of the mesoscale features is not an initial objective of the Argo network. However, it is an interesting question from the perspective of future network extensions in order to improve the ocean state estimates. The true field used to conduct the OSSEs is provided by a specific altimetry-gridded merged product for the Mediterranean Sea. Synthetic observations were obtained by sub-sampling this Nature Run according to different configurations of the ARGO network. The observation errors required to perform the OSSEs were obtained through the comparison of sea level anomalies (SLAs) from altimetry and dynamic height anomalies (DHAs) computed from the real in situ Argo network. This analysis also contributes to validate satellite SLAs with an increased confidence. The simulation experiments show that a configuration similar to the current Argo array in the Mediterranean (with a spatial resolution of 2° × 2°) is only able to recover the large-scale signals of the basin. Increasing the spatial resolution to nearly 75 km × 75 km, allows the capture of most of the mesoscale signal in the basin and to retrieve the SLA field with a RMSE of 3 cm for spatial scales larger than 150 km, similar to those presently captured by the altimetry. This would represent a theoretical reduction of 40 % of the actual RMSE. Such a high-resolution Argo array composed of around 450 floats, cycling every 10 days, is expected to increase the actual network cost by approximately a factor of 6.

  4. Validation of Aquarius sea surface salinity with in situ measurements from Argo floats and moored buoys

    NASA Astrophysics Data System (ADS)

    Tang, Wenqing; Yueh, Simon H.; Fore, Alexander G.; Hayashi, Akiko

    2014-09-01

    We validate sea surface salinity (SSS) retrieved from Aquarius instrument on SAC-D satellite with in situ measurements by Argo floats and moored buoy arrays. We assess the error structure of three Aquarius SSS products: the standard product processed by Aquarius Data Processing System (ADPS) and two data sets produced at the Jet Propulsion Laboratory (JPL): the Combined Active-Passive algorithm with and without rain correction, CAP and CAP_RC, respectively. We examine the effect of various filters to prevent unreliable point retrievals from entering Level 3 averaging, such as land or ice contamination, radio frequency interference (RFI), and cold water. Our analyses show that Aquarius SSS agrees well with Argo in a monthly average sense between 40°S and 40°N except in the Eastern Pacific Fresh Pool and Amazon River outflow. Buoy data within these regions show excellent agreement with Aquarius but have discrepancies with the Argo gridded products. Possible reasons include strong near-surface stratification and sampling problems in Argo in regions with significant western boundary currents. We observe large root-mean-square (RMS) difference and systematic negative bias between ADPS and Argo in the tropical Indian Ocean and along the Southern Pacific Convergence Zone. Excluding these regions removes the suspicious seasonal peak in the monthly RMS difference between the Aquarius SSS products and Argo. Between 40°S and 40°N, the RMS difference for CAP is less than 0.22 PSU for all 28 months, CAP_RC has essentially met the monthly 0.2 PSU accuracy requirement, while that for ADPS fluctuates between 0.22 and 0.3 PSU.

  5. Argo: enabling the development of bespoke workflows and services for disease annotation.

    PubMed

    Batista-Navarro, Riza; Carter, Jacob; Ananiadou, Sophia

    2016-01-01

    Argo (http://argo.nactem.ac.uk) is a generic text mining workbench that can cater to a variety of use cases, including the semi-automatic annotation of literature. It enables its technical users to build their own customised text mining solutions by providing a wide array of interoperable and configurable elementary components that can be seamlessly integrated into processing workflows. With Argo's graphical annotation interface, domain experts can then make use of the workflows' automatically generated output to curate information of interest.With the continuously rising need to understand the aetiology of diseases as well as the demand for their informed diagnosis and personalised treatment, the curation of disease-relevant information from medical and clinical documents has become an indispensable scientific activity. In the Fifth BioCreative Challenge Evaluation Workshop (BioCreative V), there was substantial interest in the mining of literature for disease-relevant information. Apart from a panel discussion focussed on disease annotations, the chemical-disease relations (CDR) track was also organised to foster the sharing and advancement of disease annotation tools and resources.This article presents the application of Argo's capabilities to the literature-based annotation of diseases. As part of our participation in BioCreative V's User Interactive Track (IAT), we demonstrated and evaluated Argo's suitability to the semi-automatic curation of chronic obstructive pulmonary disease (COPD) phenotypes. Furthermore, the workbench facilitated the development of some of the CDR track's top-performing web services for normalising disease mentions against the Medical Subject Headings (MeSH) database. In this work, we highlight Argo's support for developing various types of bespoke workflows ranging from ones which enabled us to easily incorporate information from various databases, to those which train and apply machine learning-based concept recognition models

  6. Atmospheric turbulence profiling using the SLODAR technique with ARGOS at LBT

    NASA Astrophysics Data System (ADS)

    Mazzoni, Tommaso; Busoni, Lorenzo; Bonaglia, Marco; Esposito, Simone

    2016-07-01

    ARGOS is the Ground Layer Adaptive Optics system of the Large Binocular Telescope, it uses three Laser Guide Stars, generated by Rayleigh backscattered light of pulsed lasers. Three Shack-Hartmann WFS measure the wavefront distortion in the Ground Layer. The SLOpe Detection And Ranging (SLODAR) is a method used to measure the turbulence profiles. Cross correlation of wavefronts gradient from multiple stars is used to estimate the relative strengths of turbulent layers at different altitudes. We present here the results on sky of the SLODAR profile on ARGOS.

  7. Gamma-ray astronomy with a large muon detector in the ARGO-YBJ experiment

    SciTech Connect

    Di Sciascio, G.; Di Girolamo, T.; Megna, R.; Saggese, L.; Fratini, K.

    2005-02-21

    The ARGO-YBJ experiment, currently under construction at the YangBaJing Laboratory (Tibet, P.R. China, 4300 m a.s.l.), could be upgraded with a large ({approx} 2500 m2) muon detector both to extend the sensitivity to {gamma}-ray sources to energies greater than {approx} 20 TeV and to perform a cosmic ray primary composition study. In this paper we present an evaluation of the rejection power for proton-induced showers achievable with the upgraded ARGO-YBJ detector. Minimum detectable {gamma}-ray fluxes are calculated for different experimental setups.

  8. Characterizing Ocean Turbulence from Argo, Acoustic Doppler, and Simulation Data

    NASA Astrophysics Data System (ADS)

    McCaffrey, Katherine

    Turbulence is inherently chaotic and unsteady, so observing it and modeling it are no easy tasks. The ocean's sheer size makes it even more difficult to observe, and its unpredictable and ever-changing forcings introduce additional complexities. Turbulence in the oceans ranges from basin scale to the scale of the molecular viscosity. The method of energy transfer between scales is, however, an area of active research, so observations of the ocean at all scales are crucial to understanding the basic dynamics of its motions. In this collection of work, I use a variety of datasets to characterize a wide range of scales of turbulence, including observations from multiple instruments and from models with different governing equations. I analyzed the largest scales of the turbulent range using the global salinity data of the Argo profiling float network. Taking advantage of the scattered and discontinuous nature of this dataset, the second-order structure function was calculated down to 2000m depth, and shown to be useful for predicting spectral slopes. Results showed structure function slopes of 2/3 at small scales, and 0 at large scales, which corresponds with spectral slopes of -5/3 at small scales, and -1 at large scales. Using acoustic Doppler velocity measurements, I characterized the meter- to kilometer-scale turbulence at a potential tidal energy site in the Puget Sound, WA. Acoustic Doppler current profiler (ADCP) and acoustic Doppler velocimeter (ADV) observations provided the data for an analysis that includes coherence, anisotropy, and intermittency. In order to more simply describe these features, a parameterization was done with four turbulence metrics, and the anisotropy magnitude, introduced here, was shown to most closely capture the coherent events. Then, using both the NREL TurbSim stochastic turbulence generator and the NCAR large-eddy simulation (LES) model, I calculated turbulence statistics to validate the accuracy of these methods in reproducing

  9. Malvinas Current variability from Argo floats and satellite altimetry

    NASA Astrophysics Data System (ADS)

    Artana, Camila; Ferrari, Ramiro; Koenig, Zoé; Saraceno, Martin; Piola, Alberto R.; Provost, Christine

    2016-07-01

    The Malvinas Current (MC) is an offshoot of the Antarctic Circumpolar Current (ACC). Downstream of Drake Passage, the northern fronts of the ACC veer northward, cross over the North Scotia Ridge (NSR) and the Malvinas Plateau, and enter the Argentine Basin. We investigate the variations of the MC circulation between the NSR and 41°S and their possible relations with the ACC circulation using data from Argo floats and satellite altimetry. The data depict meandering and eddy shedding of the northern ACC jets as they cross the NSR. The altimetry fields show that these eddies are trapped, break down, and dissipate over the Malvinas Plateau, suggesting that this region is a hot spot for dissipation of mesoscale variability. Variations of sea level anomalies (SLA) across the NSR do not impact the MC further north, except for intra-seasonal variability associated with coastal trapped waves. Altimetry and float trajectories show events during which a large fraction of the MC is cut off from the ACC. Blocking events at around 48.5°S are a recurrent feature of the MC circulation. Over the 23 year altimetry record, we detected 26 events during which the MC surface transport at 48.5°S was reduced to less than half its long-term mean. Blocking events last from 10 to 35 days and do not present any significant trend. These events were tracked back to positive SLA that built up over the Argentine Abyssal Plain. Future work is needed to understand the processes responsible for these blocking events.

  10. Intraseasonal oscillation in global ocean temperature inferred from Argo

    NASA Astrophysics Data System (ADS)

    Hu, Ruijin; Wei, Meng

    2013-01-01

    The intraseasonal oscillation (ISO; 14-97-day periods) of temperature in the upper 2000 m of the global ocean was studied based on Argo observations from 2003-2008. It is shown that near the surface the ISO existed mainly in a band east of 60°E, between 10°S and 10°N, and the region around the Antarctic Circumpolar Current (ACC). At other levels analyzed, the ISOs also existed in the regions of the Kuroshio, the Gulf Stream, the Indonesian throughflow, the Somalia current, and the subtropical countercurrent (STCC) of the North Pacific. The intraseasonal signals can be seen even at depths of about 2000 m in some regions of the global ocean. The largest amplitude of ISO appeared at the thermocline of the equatorial Pacific, Atlantic and Indian Ocean, with maximum standard deviation (STD) exceeding 1.2°C. The ACC, the Kuroshio, and the Gulf Stream regions all exhibited large STD for all levels analyzed. Especially at 1000 m, the largest STD appeared in the south and southeast of South Africa-a part of the ACC, with a maximum value that reached 0.5°C. The ratios of the intraseasonal temperature variance to the total variance at 1000 m and at the equator indicated that, in a considerable part of the global deep ocean, the ISO was dominant in the variations of temperature, since such a ratio exceeded even 50% there. A case study also confirmed the existence of the ISO in the deep ocean. These results provide useful information for the design of field observations in the global ocean. Analysis and discussion are also given for the mechanism of the ISO.

  11. 15 CFR Appendix A to Part 911 - Argos DCS Use Policy Diagram

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Appendix A to Part 911 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade... POLICIES AND PROCEDURES CONCERNING USE OF THE NOAA SPACE-BASED DATA COLLECTION SYSTEMS Pt. 911, App. A Appendix A to Part 911—Argos DCS Use Policy Diagram ER01AU03.015 ...

  12. 15 CFR Appendix A to Part 911 - Argos DCS Use Policy Diagram

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Appendix A to Part 911 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade... POLICIES AND PROCEDURES CONCERNING USE OF THE NOAA SPACE-BASED DATA COLLECTION SYSTEMS Pt. 911, App. A Appendix A to Part 911—Argos DCS Use Policy Diagram ER01AU03.015 ...

  13. 15 CFR Appendix A to Part 911 - Argos DCS Use Policy Diagram

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Appendix A to Part 911 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade... POLICIES AND PROCEDURES CONCERNING USE OF THE NOAA SPACE-BASED DATA COLLECTION SYSTEMS Pt. 911, App. A Appendix A to Part 911—Argos DCS Use Policy Diagram ER01AU03.015 ...

  14. 15 CFR Appendix A to Part 911 - Argos DCS Use Policy Diagram

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Appendix A to Part 911 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade... POLICIES AND PROCEDURES CONCERNING USE OF THE NOAA SPACE-BASED DATA COLLECTION SYSTEMS Pt. 911, App. A Appendix A to Part 911—Argos DCS Use Policy Diagram ER01AU03.015 ...

  15. 15 CFR Appendix A to Part 911 - Argos DCS Use Policy Diagram

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Appendix A to Part 911 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade... POLICIES AND PROCEDURES CONCERNING USE OF THE NOAA SPACE-BASED DATA COLLECTION SYSTEMS Pt. 911, App. A Appendix A to Part 911—Argos DCS Use Policy Diagram ER01AU03.015 ...

  16. Argos induces programmed cell death in the developing Drosophila eye by inhibition of the Ras pathway.

    PubMed

    Sawamoto, K; Taguchi, A; Hirota, Y; Yamada, C; Jin, M H; Okano, H

    1998-04-01

    We studied the role of Ras signaling in the regulation of cell death during Drosophila eye development. Overexpression of Argos, a diffusible inhibitor of the EGF receptor and Ras signaling, caused excessive cell death in developing eyes at pupal stages. The Argos-induced cell death was suppressed by coexpression of the anti-apoptotic genes p35, diap1, or diap2 in the eye as well as by the Df(3L)H99 chromosomal deletion that lacks three apoptosis-inducing genes, reaper, head involution defective (hid) and grim. Transient misexpression of the activated Ras1 protein (Ras1V12) later in pupal development suppressed the Argos-induced cell death. Thus, Argos-induced cell death seemed to have resulted from the suppression of the anti-apoptotic function of Ras. Conversely, cell death induced by overexpression of Hid was suppressed by gain-of-function mutations of the genes coding for MEK and ERK. These results support the idea that Ras signaling functions in two distinct processes during eye development, first triggering the recruitment of cells and later negatively regulating cell death.

  17. Assessment of the Black Sea observing system. A focus on 2005-2012 Argo campaigns

    NASA Astrophysics Data System (ADS)

    Grayek, Sebastian; Stanev, Emil V.; Schulz-Stellenfleth, Johannes

    2015-12-01

    An observing system in the Black Sea combining remote sensing data such as sea level anomalies from altimetry, sea surface temperature from satellite radiometer and data from Argo floats has been analyzed with the aim to quantify the contribution of different information sources when reconstructing the ocean state. The main research questions are: (1) do Argo float measurements substantially impact the quality of estimates, (2) what is the dependence of this quality upon the data and sampling used, and (3) are there specific Black Sea issues? Numerical model output and statistical analysis were used for this purpose. It has been demonstrated that the statistical method performs in a consistent way reproducing known geophysical patterns. Maximum footprints of sea level, salinity and temperature were illustrated, most of them clearly connected with specific thermohaline conditions and the general circulation. Reduced analysis capabilities were identified as associated with a low level of dynamical coupling between the shelf and the open ocean, mesoscale dynamics and representation of diapycnic processes in the models. The accuracy of Argo pressure measurements appeared very important to resolve the extremely sharp stratification in the upper layers. The present-day number of Argo floats operating in the Black Sea of about 10, seems optimal for operational purposes.

  18. Shaken but not stirred: Multiscale habitat suitability modeling of sympatric marten species (Martes martes and Martes foina) in the northern Iberian Peninsula

    Treesearch

    Maria Vergara; Samuel A. Cushman; Fermin Urra; Aritz Ruiz-Gonzalez

    2016-01-01

    Multispecies and multiscale habitat suitability models (HSM) are important to identify the environmental variables and scales influencing habitat selection and facilitate the comparison of closely related species with different ecological requirements. Objectives This study explores the multiscale relationships of habitat suitability for the pine (Martes...

  19. Radio-tracking large wilderness mammals: integration of GPS and Argos technologies

    USGS Publications Warehouse

    Schwartz, Charles C.; Arthur, Steve M.

    1999-01-01

    We tested 30 prototype global positioning system (GPS) radiocollars on brown bears (Ursus arctos) over a 3-year period on the Kenai Peninsula, Alaska. Collars were of 2 design types: GPS units with an Argos (Argos Data collection and Location System) satellite uplink (n = 19) and GPS units where the data were stored on board (n = 10) for retrieval at a later date. All units also contained a conventional VHF (very high frequency) transmitter and weighed 1.7 kg. GPS-Argos units obtained 10-82% of expected GPS fixes, and fix rate declined significantly (P < 0.05) with time after deployment. Argos uplink success (proportion of successful transmissions of stored data) was linearly related to GPS fix rate (r = 0.91, P < 0.001). Storeon-board units obtained significantly more successful fixes when compared with the GPS-Argos units (t = -4.009, P < 0.001). Fix success rate for deployed store-on-board collars ranged from 13-96%; because of the increased number of attempted fixes per day, these collars obtained fixes on 97% of days deployed. Accuracy of the GPS units was less than predicted by the NAVSTAR GPS technology using the course acquisition code. Reduced accuracy was likely a result of the proportion of 2-dimensional versus 3-dimensional fixes obtained, although we could not determine this statistic from recorded data. Increased overstory closure was the only variable measured that partially explained the reduced likelihood of a successful fix. Stem density, stem diameter, and overstory height measured within 3 m of the collar did not affect fix success. GPS fix success rates for collars attached to bears varied more and were lower than fix rates for stationary collars placed in various vegetation types, suggesting that the bear, terrain, and movement all influence both fix and uplink success rate. Application of this new technology to grizzly and brown bear research and comparisons to studies with moose (Alces alces) are discussed.

  20. Argo - A Voyage Through the Outer Solar System: An Innovative New Frontiers Concept

    NASA Astrophysics Data System (ADS)

    Stansberry, John A.; Hansen, C.; Hammel, H.; Spilker, L.; Spilker, T.; Aljabri, A.; Banfield, D.; Brown, M.; Colwell, J.; Dougherty, M.; Hendrix, A.; Khurana, K.; McEwen, A.; McNutt, R.; Paige, D.; Satter, C.; Showalter, M.; Strange, N.

    2008-09-01

    Recent, ongoing, and planned space missions exist for terrestrial planets, gas giant systems, and Pluto, but not for the ice giant systems and the rest of the outer Solar System. Argo will fill this major gap by encountering the Neptune system and then continuing on to encounter a large (or otherwise interesting) Kuiper Belt Object (KBO). Exploration of the Neptune system has been stymied by a perception that a flagship-class orbiter is required for major scientific progress. Yet our understanding of the Neptune system has improved dramatically since Voyager. By capitalizing on that new knowledge and using current technology, the Argo flyby will revolutionize our knowledge of Neptune, its atmosphere, magnetosphere and rings, and Triton and other moons. A close flyby of Triton will allow high-resolution mapping, near-IR spectral maps, and radio and solar occultations for atmospheric studies. The Neptune gravity-assist allows access to a huge cone ( 4000x greater than for New Horizons) of the Kuiper Belt, including many potential, known KBO targets to choose from. Combined with New Horizons’ exploration of Pluto and a KBO, Argo's study of Triton (a captured dwarf-planet) and another KBO will double the number of KBOs/dwarf-planets with detailed spacecraft studies. Argo combines a focused science package, current instrument technology, and current spacecraft technology with several launch opportunities that exist in the next decade, and provides a mission concept that fits within the expected New Frontiers cost envelope. Our mission concept includes avenues for cost savings in development, operations, and the launch vehicle. Argo will require nuclear power, so the concept will be submitted for the fourth New Frontiers (not the current NF03) call.

  1. The MARTE VNIR imaging spectrometer experiment: design and analysis.

    PubMed

    Brown, Adrian J; Sutter, Brad; Dunagan, Stephen

    2008-10-01

    We report on the design, operation, and data analysis methods employed on the VNIR imaging spectrometer instrument that was part of the Mars Astrobiology Research and Technology Experiment (MARTE). The imaging spectrometer is a hyperspectral scanning pushbroom device sensitive to VNIR wavelengths from 400-1000 nm. During the MARTE project, the spectrometer was deployed to the Río Tinto region of Spain. We analyzed subsets of three cores from Río Tinto using a new band modeling technique. We found most of the MARTE drill cores to contain predominantly goethite, though spatially coherent areas of hematite were identified in Core 23. We also distinguished non Fe-bearing minerals that were subsequently analyzed by X-ray diffraction (XRD) and found to be primarily muscovite. We present drill core maps that include spectra of goethite, hematite, and non Fe-bearing minerals.

  2. Error attribution and validation of SMOS high-level salinity products with Argo data

    NASA Astrophysics Data System (ADS)

    Ballabrera, Joaquim

    2015-04-01

    In the context of the E-AIMS project (7FP Project No. 284391), the role and suggested improvements of the Argo array in the validation of SMOS sea surface salinity (SSS) have been investigated. Here, a summary of the main results is shown and discussed. The Argo array continues to be the sole component of the ocean observing system to provide routine observations of temperature and salinity profiles at global scale with a time sampling period of about ten days. The observations provided by an Argo profiler are publicly available a few days from being taken (Real Time Mode) after application of automatic quality control filters. Scientific quality data (Delayed Mode) is generated after a human supervised quality control. In this study, the highest quality, delayed mode, near-the-surface data are being used to validate the SSS Level 3 and Level 4 products generated by the SMOS Barcelona Expert Centre (http://cp34-bec.cmima.csic.es). The products being validated here are the weighted binned average (L3), an Optimal Interpolation (OI), and a data fused product exploiting the spatial variability of OSTIA SST. An Argo profile is considered if its quality flags of position and time are equal to one (good), two (probably good), five (value changes) or eight (value interpolated). However, temperature, salinity and pressure data are used only if their quality flags are equal to one (good). The uppermost (but deeper than 0.5 m) salinity measurement is taken as an approximation of the in-situ SSS, but only if the salinity profile allows a robust interpolation of the salinity at 7.5 m (this additional requirement is introduced to ensure that the salinity profile is properly sampled near the surface). At the moment of performing this study, the main drawbacks have been the lag in the Delayed Mode processing, and the lack of salinity observations in the first five meters below the ocean surface. While 5500 profiles in Delayed Mode were available for January 2011, about 1000 were

  3. Enhancing the use of Argos satellite data for home range and long distance migration studies of marine animals.

    PubMed

    Hoenner, Xavier; Whiting, Scott D; Hindell, Mark A; McMahon, Clive R

    2012-01-01

    Accurately quantifying animals' spatial utilisation is critical for conservation, but has long remained an elusive goal due to technological impediments. The Argos telemetry system has been extensively used to remotely track marine animals, however location estimates are characterised by substantial spatial error. State-space models (SSM) constitute a robust statistical approach to refine Argos tracking data by accounting for observation errors and stochasticity in animal movement. Despite their wide use in ecology, few studies have thoroughly quantified the error associated with SSM predicted locations and no research has assessed their validity for describing animal movement behaviour. We compared home ranges and migratory pathways of seven hawksbill sea turtles (Eretmochelys imbricata) estimated from (a) highly accurate Fastloc GPS data and (b) locations computed using common Argos data analytical approaches. Argos 68(th) percentile error was <1 km for LC 1, 2, and 3 while markedly less accurate (>4 km) for LC ≤ 0. Argos error structure was highly longitudinally skewed and was, for all LC, adequately modelled by a Student's t distribution. Both habitat use and migration routes were best recreated using SSM locations post-processed by re-adding good Argos positions (LC 1, 2 and 3) and filtering terrestrial points (mean distance to migratory tracks ± SD = 2.2 ± 2.4 km; mean home range overlap and error ratio = 92.2% and 285.6 respectively). This parsimonious and objective statistical procedure however still markedly overestimated true home range sizes, especially for animals exhibiting restricted movements. Post-processing SSM locations nonetheless constitutes the best analytical technique for remotely sensed Argos tracking data and we therefore recommend using this approach to rework historical Argos datasets for better estimation of animal spatial utilisation for research and evidence-based conservation purposes.

  4. Consistency of Aquarius version-4 sea surface salinity with Argo products on various spatial and temporal scales

    NASA Astrophysics Data System (ADS)

    Lee, T.

    2016-12-01

    Understanding the accuracies of satellite-derived sea surface salinity (SSS) measurements in depicting temporal changes and the dependence of the accuracies on spatio-temporal scales are important to applications, capability assessment, and future mission design. This study quantifies the consistency between Aquarius Version-4 monthly gridded SSS (released in October 2015) with two widely used Argo monthly gridded near-surface salinity products. The analysis focused on their consistency in depicting temporal changes (including seasonal and non-seasonal) on various spatial scales: 1°x1°, 3°x3°, and 10°x10°. Globally averaged standard deviation (STD) values for Aquarius-Argo salinity differences on these three spatial scales are 0.16, 0.14, 0.09 psu, compared to those between the two Argo products of 0.10, 0.09, and 0.04 psu. Aquarius SSS compare better with Argo data on non-seasonal (e.g., interannual and intraseasonal) than for seasonal time scales. The seasonal Aquarius-Argo SSS differences are mostly concentrated at high latitudes. The Aquarius team is making active efforts to further reduce these high-latitude seasonal biases. The consistency between Aquarius and Argo salinity is similar to that between the two Argo products in the tropics and subtropics for non-seasonal signals, and in the tropics for seasonal signals. Therefore, the representativeness errors of the Argo products for various spatial scales (related to sampling and gridding) need to be taken into account when estimating the uncertainty of Aquarius SSS. The globally averaged uncertainty of large-scale (10°x10°) non-seasonal Aquarius SSS is approximately 0.04 psu. These estimates reflect the significant improvements of Aquarius Version-4 SSS over the previous versions. The estimates can be used as baseline requirements for future ocean salinity missions from space.

  5. Enhancing the Use of Argos Satellite Data for Home Range and Long Distance Migration Studies of Marine Animals

    PubMed Central

    Hoenner, Xavier; Whiting, Scott D.; Hindell, Mark A.; McMahon, Clive R.

    2012-01-01

    Accurately quantifying animals’ spatial utilisation is critical for conservation, but has long remained an elusive goal due to technological impediments. The Argos telemetry system has been extensively used to remotely track marine animals, however location estimates are characterised by substantial spatial error. State-space models (SSM) constitute a robust statistical approach to refine Argos tracking data by accounting for observation errors and stochasticity in animal movement. Despite their wide use in ecology, few studies have thoroughly quantified the error associated with SSM predicted locations and no research has assessed their validity for describing animal movement behaviour. We compared home ranges and migratory pathways of seven hawksbill sea turtles (Eretmochelys imbricata) estimated from (a) highly accurate Fastloc GPS data and (b) locations computed using common Argos data analytical approaches. Argos 68th percentile error was <1 km for LC 1, 2, and 3 while markedly less accurate (>4 km) for LC ≤0. Argos error structure was highly longitudinally skewed and was, for all LC, adequately modelled by a Student’s t distribution. Both habitat use and migration routes were best recreated using SSM locations post-processed by re-adding good Argos positions (LC 1, 2 and 3) and filtering terrestrial points (mean distance to migratory tracks ± SD = 2.2±2.4 km; mean home range overlap and error ratio  = 92.2% and 285.6 respectively). This parsimonious and objective statistical procedure however still markedly overestimated true home range sizes, especially for animals exhibiting restricted movements. Post-processing SSM locations nonetheless constitutes the best analytical technique for remotely sensed Argos tracking data and we therefore recommend using this approach to rework historical Argos datasets for better estimation of animal spatial utilisation for research and evidence-based conservation purposes. PMID:22808241

  6. Overexpression of ARGOS Genes Modifies Plant Sensitivity to Ethylene, Leading to Improved Drought Tolerance in Both Arabidopsis and Maize[OPEN

    PubMed Central

    Shi, Jinrui; Habben, Jeffrey E.; Archibald, Rayeann L.; Drummond, Bruce J.; Chamberlin, Mark A.; Williams, Robert W.; Lafitte, H. Renee; Weers, Ben P.

    2015-01-01

    Lack of sufficient water is a major limiting factor to crop production worldwide, and the development of drought-tolerant germplasm is needed to improve crop productivity. The phytohormone ethylene modulates plant growth and development as well as plant response to abiotic stress. Recent research has shown that modifying ethylene biosynthesis and signaling can enhance plant drought tolerance. Here, we report novel negative regulators of ethylene signal transduction in Arabidopsis (Arabidopsis thaliana) and maize (Zea mays). These regulators are encoded by the ARGOS gene family. In Arabidopsis, overexpression of maize ARGOS1 (ZmARGOS1), ZmARGOS8, Arabidopsis ARGOS homolog ORGAN SIZE RELATED1 (AtOSR1), and AtOSR2 reduced plant sensitivity to ethylene, leading to enhanced drought tolerance. RNA profiling and genetic analysis suggested that the ZmARGOS1 transgene acts between an ethylene receptor and CONSTITUTIVE TRIPLE RESPONSE1 in the ethylene signaling pathway, affecting ethylene perception or the early stages of ethylene signaling. Overexpressed ZmARGOS1 is localized to the endoplasmic reticulum and Golgi membrane, where the ethylene receptors and the ethylene signaling protein ETHYLENE-INSENSITIVE2 and REVERSION-TO-ETHYLENE SENSITIVITY1 reside. In transgenic maize plants, overexpression of ARGOS genes also reduces ethylene sensitivity. Moreover, field testing showed that UBIQUITIN1:ZmARGOS8 maize events had a greater grain yield than nontransgenic controls under both drought stress and well-watered conditions. PMID:26220950

  7. La historia orbital de Deimos y la oblicuidad de Marte

    NASA Astrophysics Data System (ADS)

    Brunini, A.; Yokoyama, T.

    Recientemente, se ha demostrado mediante extensas integraciones numéricas, que la rotación de Marte pasó repetidamente por estados caóticos de movimiento, debido al pasaje por zonas de resonancia spin - órbita. En dichas circunstancias, la oblicuidad marciana pudo haber sufrido grandes excursiones de varias decenas de grados. Las consecuencias de dichas variaciones son de extrema importancia en el contexto de la búsqueda de manifestaciones de vida fósil en dicho planeta. El estudio de la dinámica orbital del satélite más exterior de Marte, Deimos, nos ha permitido comprobar, en el marco de las distintas teorías sobre su orígen, que la oblicuidad de Marte dificilmente pudo haber sufrido variaciones que la aparten más de 10o respecto de actual valor. Este resultado parece ser mucho más robusto que las simulaciones numéricas de Touma y Wisdom asi como las de Laskar y Robutel, lo que permite poner cotas más severas a la evolución paleoclimática de Marte.

  8. Current distribution of the fisher, Martes pennanti, in California

    Treesearch

    William J. Zielinski; Thomas E. Kucera; Reginald H. Barrett

    1995-01-01

    We describe the 1989-1994 distribution of the fisher, Martes pennanti, in California based on results of detection surveys that used either sooted track-plates or cameras. Fishers were detected in two regions of the state: the northwest and the southern Sierra Nevada. Despite considerable survey effort, neither fisher tracks nor photographs were...

  9. Monitoring Martes populations in California: survey design and power analysis

    Treesearch

    William J. Zielinski; Howard B. Stauffer

    1996-01-01

    Fishers (Martes pennanti) and American martens (M. americana) have been protected from trapping in California since the mid-1900s, yet in portions of each of their historic ranges their numbers are extremely low, perhaps due to the effects of timber harvest. We propose a method capable of detecting declines in the occurrence and...

  10. "Dateline NBC"'s Persuasive Attack on Wal-Mart.

    ERIC Educational Resources Information Center

    Benoit, William L.; Dorries, Bruce

    1996-01-01

    Develops a typology of persuasive attack strategies. Identifies two key components of persuasive attack: responsibility and offensiveness. Describes several strategies for intensifying each of these elements. Applies this analysis to "Dateline NBC"'s allegations that Wal-Mart's "Buy American" campaign was deceptive. Concludes…

  11. Current distribution of the american marten, Martes americana, in California

    Treesearch

    Thomas E. Kurcera; William J. Zielinski; Reginald H. Barrett

    1996-01-01

    We describe the current distribution of the American marten, Martes americana, in California based on field surveys conducted between 1989 and 1995 that used either sooted track-plates or cameras. The Sierra Nevada marten, M. a. sierrae, occupies much of its historic range from northwestern Shasta County to the southern Sierra...

  12. Improvement of ocean state estimation by assimilating mapped Argo drift data.

    PubMed

    Masuda, Shuhei; Sugiura, Nozomi; Osafune, Satoshi; Doi, Toshimasa

    2014-01-01

    We investigated the impact of assimilating a mapped dataset of subsurface ocean currents into an ocean state estimation. We carried out two global ocean state estimations from 2000 to 2007 using the K7 four-dimensional variational data synthesis system, one of which included an additional map of climatological geostrophic currents estimated from the global set of Argo floats. We assessed the representativeness of the volume transport in the two exercises. The assimilation of Argo ocean current data at only one level, 1000 dbar depth, had subtle impacts on the estimated volume transports, which were strongest in the subtropical North Pacific. The corrections at 10(°)N, where the impact was most notable, arose through the nearly complete offset of wind stress curl by the data synthesis system in conjunction with the first mode baroclinic Rossby wave adjustment. Our results imply that subsurface current data can be effective for improving the estimation of global oceanic circulation by a data synthesis.

  13. Final design of the wavefront sensor unit for ARGOS, the LBT's LGS facility

    NASA Astrophysics Data System (ADS)

    Busoni, Lorenzo; Bonaglia, Marco; Esposito, Simone; Carbonaro, Luca; Rabien, Sebastian

    2010-07-01

    In this paper we present the final design of the WFS unit of LBT's ARGOS facility, that will implement a GLAO system using 3 Rayleigh pulsed beacons. The ARGOS WFS is composed of two main subunits: 1) a large dichroic window that deflects the laser beam toward the WFS and transmit the visible and near-infrared wavelength to the MOSimager LUCIFER and 2) the SH-WFS that collects the backscattered light of the 3 beacons and combines the beams on a single lenslet array and detector. The WFS unit includes Pockels cells for the range gating of the laser beams, field and pupil stabilizers to compensate for the fast jitter of the laser beams and for optical flexures and a calibration unit to check the internal alignment; this unit will be also used for closed-loop laboratory tests using a MEMS-DM.

  14. Preliminary results of the Moon shadow using ARGO-YBJ detector

    NASA Astrophysics Data System (ADS)

    ARGO-YBJ Collaboration

    2008-01-01

    ARGO-YBJ is a “full coverage” air shower detector consisting of Resistive Plate Chambers(RPCs) at the Yangbajing High Altitude Cosmic Ray Laboratory (Tibet, China) at 4300 m a.s.l. (lat=30.11° N, long=90.53° E). Using the data collected with a carpet of RPCs (1900m2, about 1/3 of the whole ARGO-YBJ detector), the cosmic ray shadowing effect due to the Moon was studied. The 50% angular resolution is found to be ˜1.2° with the Chess-board method and the Moon shadow with a significance of 4.9 σ is found displaced by 0.7° westward and 0.5° northward with respect to the expected position by the equi-zenith angle Method.

  15. Recent results from ArgoNeuT and status of MicroBooNE

    SciTech Connect

    Szelc, A. M.

    2015-07-15

    Liquid Argon Time Projection Chambers (LArTPCs) are a novel detector technology for neutrino detection experiments. Their fine granularity combined with calorimetric capabilities allows for precision measurements that will answer the outstanding questions about the role of neutrinos in the Standard Model of Particle physics and beyond it. Here, we discuss the development effort underway in the framework of the US based LArTPC program, which ties improving the reach of the technology with relevant physics measurements of beam neutrinos at Fermilab. Examples of experiments in this program are ArgoNeuT which ran on the NuMI beam line and acquired 1.35×10{sup 20} POT and MicroBooNE which is set to run on the Booster neutrino beamline at the beginning of 2015. Recent results from the ArgoNeuT experiment will be discussed as well as the status and prospects for MicroBooNE.

  16. Diagnosing overturning and water mass transformation in the Labrador Sea from Argo and PALACE floats

    NASA Astrophysics Data System (ADS)

    Holte, J.; Straneo, F.

    2016-02-01

    We use Argo and PALACE floats, which have been sampling the Labrador Sea since the mid 1990s, to examine the Labrador Sea overturning and its variability on seasonal and decadal timescales. Floats have collected observations in all seasons as well as in the boundary current, allowing for an examination of the seasonal signal of the overturning and of the boundary current's contribution to the overturning. We construct seasonal composite geostrophic velocity sections across the mouth of the Labrador Sea from potential density profiles and float trajectories at 1000 m. The velocity sections are used to calculate the horizontal and overturning circulations and the water mass transformation. We also track the seasonal and spatial patterns of properties in the boundary current to evaluate theoretical estimates of sinking in the boundary current. The recent Argo observations, collected during a period of relatively weak deep convection, are compared to PALACE float observations from the mid-1990s, a period of stronger deep convection.

  17. Improvement of bias detection in Argo float conductivity sensors and its application in the North Atlantic

    NASA Astrophysics Data System (ADS)

    Cabanes, Cécile; Thierry, Virginie; Lagadec, Catherine

    2016-08-01

    We propose modifications of the OW method (Owens and Wong, 2009) used to estimate the time-varying correction of conductivity measurements from Argo floats. These modifications are necessary to account for large interannual to decadal variability of the large-scale salinity field observed, for instance, in the North-Atlantic Ocean and to provide corrections with realistic error bars. The covariance function used to map reference salinity data at the float profile position was modified in order to minimize the contribution of the oldest reference data to the large-scale salinity field estimate. Mapping error now includes errors in the large-scale field estimates and fit error now takes into account the lateral dependence between climatological profiles. Finally, we used the modified OW method to check the consistency of the Argo salinity dataset available in delayed mode in the North-Atlantic Ocean. Overall, salinity corrections need to be reconsidered for 4.5% of the floats.

  18. Gamma rays from dark matter annihilation in the Draco and observability at ARGO

    NASA Astrophysics Data System (ADS)

    Bi, X.-J.; Hu, H.-B.; Zhang, X.

    2006-11-01

    The CACTUS experiment recently observed a gamma ray excess above 50 GeV from the direction of the Draco dwarf spheroidal galaxy. Considering that Draco is dark matter dominated, the gamma rays may be generated through dark matter annihilation in the Draco halo. In the framework of the minimal supersymmetric extension of the standard model we explore the parameter space to account for the gamma ray signals at CACTUS. We find that the neutralino mass is constrained to be approximately in the range between 100 GeV˜400 GeV and a sharp central cuspy of the dark halo profile in Draco is necessary to explain the CACTUS results. We then discuss further constraints on the supersymmetric parameter space by observations at the ground-based ARGO detector. It is found that the parameter space can be strongly constrained by ARGO if no excess from Draco is observed above 100 GeV.

  19. Exclusive xB5+Np topologies with ArgoNeuT

    NASA Astrophysics Data System (ADS)

    Partyka, Kinga

    2015-05-01

    The Argon Neutrino Test, ArgoNeuT, is a small scale Liquid Argon Time Projection Chamber (LAr TPC) that is one step towards the construction of large scale LAr TPCs for long-baseline neutrino physics. LArTPCs provide bubble-chamber-like quality images for excellent particle ID and background rejection. Due to its superb capabilities it is well suited for topological analysis by reporting what it sees in a final state. Preliminary analysis of ArgoNeuT's 0.1 to 10 GeV neutrino µ+Np topologies together with first ever study of proton multiplicities in neutrino-argon interactions was presented and compared with GENIE Monte Carlo generator.

  20. Air Shower Detection and Sky Survey with the ARGO-YBJ Experiment

    SciTech Connect

    Bleve, C.

    2006-02-08

    The ARGO-YBJ detector, located in Tibet at 4300 m a.s.l., is a full-coverage Extensive Air-Shower Array consisting of a single layer of Resistive Plate Chambers. The main scientific goals of the experiment are the study of cosmic rays and the detection of astrophysical {gamma} radiation at few hundreds GeV energy threshold. About 30% of the foreseen active area is in stable data taking since December 2004. The analysis of first data shows that the detector is working properly and that ARGO-YBJ has the capability to image extensive air showers with unprecedented granularity and to monitor continuously the Northern Sky searching for steady and transient sources of {gamma}-rays. In this paper we report some results about the air shower detection and the first sky map covering the declination band -20 deg. < {delta} <80 deg.

  1. Energy spectrum of cosmic ray protons and helium nuclei measured by the ARGO-YBJ experiment

    NASA Astrophysics Data System (ADS)

    Mari, S. M.; Montini, P.

    2014-04-01

    The ARGO-YBJ experiment is a full-coverage air shower detector operating at the Yangbajing International Cosmic Ray Observatory (Tibet, PR China, 4300 m a.s.l.). The detector was in stable data taking in its full configuration from November 2007 to February 2013. More than 5 ×1011 events have been collected and reconstructed. Due to its characteristics (full-coverage, high segmentation, high altitude operation) the ARGO-YBJ experiment is able to investigate the cosmic ray energy spectrum in a wide energy range and offer the possibility of measuring the cosmic ray light component spectrum down to the TeV region, where direct balloon-borne measurements are available. In this work we present the measurement of the proton and helium spectra in the energy range 1-300 TeV by using a large data sample collected between January 2008 and December 2011.

  2. Argo: an integrative, interactive, text mining-based workbench supporting curation

    PubMed Central

    Rak, Rafal; Rowley, Andrew; Black, William; Ananiadou, Sophia

    2012-01-01

    Curation of biomedical literature is often supported by the automatic analysis of textual content that generally involves a sequence of individual processing components. Text mining (TM) has been used to enhance the process of manual biocuration, but has been focused on specific databases and tasks rather than an environment integrating TM tools into the curation pipeline, catering for a variety of tasks, types of information and applications. Processing components usually come from different sources and often lack interoperability. The well established Unstructured Information Management Architecture is a framework that addresses interoperability by defining common data structures and interfaces. However, most of the efforts are targeted towards software developers and are not suitable for curators, or are otherwise inconvenient to use on a higher level of abstraction. To overcome these issues we introduce Argo, an interoperable, integrative, interactive and collaborative system for text analysis with a convenient graphic user interface to ease the development of processing workflows and boost productivity in labour-intensive manual curation. Robust, scalable text analytics follow a modular approach, adopting component modules for distinct levels of text analysis. The user interface is available entirely through a web browser that saves the user from going through often complicated and platform-dependent installation procedures. Argo comes with a predefined set of processing components commonly used in text analysis, while giving the users the ability to deposit their own components. The system accommodates various areas and levels of user expertise, from TM and computational linguistics to ontology-based curation. One of the key functionalities of Argo is its ability to seamlessly incorporate user-interactive components, such as manual annotation editors, into otherwise completely automatic pipelines. As a use case, we demonstrate the functionality of an in

  3. Argo: an integrative, interactive, text mining-based workbench supporting curation.

    PubMed

    Rak, Rafal; Rowley, Andrew; Black, William; Ananiadou, Sophia

    2012-01-01

    Curation of biomedical literature is often supported by the automatic analysis of textual content that generally involves a sequence of individual processing components. Text mining (TM) has been used to enhance the process of manual biocuration, but has been focused on specific databases and tasks rather than an environment integrating TM tools into the curation pipeline, catering for a variety of tasks, types of information and applications. Processing components usually come from different sources and often lack interoperability. The well established Unstructured Information Management Architecture is a framework that addresses interoperability by defining common data structures and interfaces. However, most of the efforts are targeted towards software developers and are not suitable for curators, or are otherwise inconvenient to use on a higher level of abstraction. To overcome these issues we introduce Argo, an interoperable, integrative, interactive and collaborative system for text analysis with a convenient graphic user interface to ease the development of processing workflows and boost productivity in labour-intensive manual curation. Robust, scalable text analytics follow a modular approach, adopting component modules for distinct levels of text analysis. The user interface is available entirely through a web browser that saves the user from going through often complicated and platform-dependent installation procedures. Argo comes with a predefined set of processing components commonly used in text analysis, while giving the users the ability to deposit their own components. The system accommodates various areas and levels of user expertise, from TM and computational linguistics to ontology-based curation. One of the key functionalities of Argo is its ability to seamlessly incorporate user-interactive components, such as manual annotation editors, into otherwise completely automatic pipelines. As a use case, we demonstrate the functionality of an in

  4. Tropical Cyclone Footprint in the Ocean Mixed Layer Observed by Argo in the Northwest Pacific

    DTIC Science & Technology

    2014-10-25

    RESEARCH ARTICLE 10.1002/2014JC010316 Tropical cyclone footprint in the ocean mixed layer observed by Argo in the Northwest Pacific HongLi Fu1...Postgraduate School, Monterey, California, USA Abstract This study systematically investigated the ocean mixed layer responses to tropical cyclone (TC...5 m, with IL cooling up to 0.4C. 1. Introduction Oceanic response to tropical cyclones (TCs) has been a hot topic due to its importance for climate

  5. Impact study of the Argo array definition in the Mediterranean Sea based on satellite altimetry gridded data

    NASA Astrophysics Data System (ADS)

    Sanchez-Roman, Antonio; Ruiz, Simón; Pascual, Ananda; Guinehut, Stéphanie; Mourre, Baptiste

    2016-04-01

    The existing Argo network provides essential data in near real time to constrain monitoring and forecasting centers and strongly complements the observations of the ocean surface from space. The comparison of Sea Level Anomalies (SLA) provided by satellite altimeters with in-situ Dynamic Heights Anomalies (DHA) derived from the temperature and salinity profiles of Argo floats contribute to better characterize the error budget associated with the altimeter observations. In this work, performed in the frame of the E-AIMS FP7 European Project, we focus on the Argo observing system in the Mediterranean Sea and its impact on SLA fields provided by satellite altimetry measurements in the basin. Namely, we focus on the sensitivity of specific SLA gridded merged products provided by AVISO in the Mediterranean to the reference depth (400 or 900 dbar) selected in the computation of the Argo Dynamic Height (DH) as an integration of the Argo T/S profiles through the water column. This reference depth will have impact on the number of valid Argo profiles and therefore on their temporal sampling and the coverage by the network used to compare with altimeter data. To compare both datasets, altimeter grids and synthetic climatologies used to compute DHA were spatially and temporally interpolated at the position and time of each in-situ Argo profile by a mapping method based on an optimal interpolation scheme. The analysis was conducted in the entire Mediterranean Sea and different sub-regions of the basin. The second part of this work is devoted to investigate which configuration in terms of spatial sampling of the Argo array in the Mediterranean will properly reproduce the mesoscale dynamics in this basin, which is comprehensively captured by new standards of specific altimeter products for this region. To do that, several Observing System Simulation Experiments (OSSEs) were conducted assuming that altimetry data computed from AVISO specific reanalysis gridded merged product for

  6. A comparison of indirect measures of feeding behaviour based on ARGOS tracking data

    NASA Astrophysics Data System (ADS)

    Robinson, P. W.; Tremblay, Y.; Crocker, D. E.; Kappes, M. A.; Kuhn, C. E.; Shaffer, S. A.; Simmons, S. E.; Costa, D. P.

    2007-02-01

    ARGOS tracking data are frequently used to infer feeding locations of marine predators. Most track-based methods rely on the assumption that feeding takes place within regions of area-restricted search (ARS); however, it is unclear whether the spatial accuracy and temporal resolution of ARGOS-quality data are sufficient to extract the location of ARSs at the resolution of individual feeding bouts. Using ARGOS tracking data from northern elephant seals ( Mirounga angustirostris) and Laysan albatrosses ( Phoebastria immutabilis), we tested several track-based estimators of feeding locations against independent feeding proxies (dive type or shape and number of landing events). The track-based methods were: turn angle, transit rate, first-passage time, and fractal dimension. None of these methods provided a reliable estimate of putative feeding activity at the species level, as measured by dive-type analysis or landing events. At the individual level, variation in agreement between track-based estimates and feeding proxies highlighted the importance of considering the effect of spatial scale. Biological justification of track-based metrics should be more carefully assessed before assigning particular functions to individual tracks (feeding/foraging/searching/transit) or groups of tracks (biological hotspots).

  7. The ARGO Project: assessing NA-TECH risks on off-shore oil platforms

    NASA Astrophysics Data System (ADS)

    Capuano, Paolo; Basco, Anna; Di Ruocco, Angela; Esposito, Simona; Fusco, Giannetta; Garcia-Aristizabal, Alexander; Mercogliano, Paola; Salzano, Ernesto; Solaro, Giuseppe; Teofilo, Gianvito; Scandone, Paolo; Gasparini, Paolo

    2017-04-01

    ARGO (Analysis of natural and anthropogenic risks on off-shore oil platforms) is a 2 years project, funded by the DGS-UNMIG (Directorate General for Safety of Mining and Energy Activities - National Mining Office for Hydrocarbons and Georesources) of Italian Ministry of Economic Development. The project, coordinated by AMRA (Center for the Analysis and Monitoring of Environmental Risk), aims at providing technical support for the analysis of natural and anthropogenic risks on offshore oil platforms. In order to achieve this challenging objective, ARGO brings together climate experts, risk management experts, seismologists, geologists, chemical engineers, earth and coastal observation experts. ARGO has developed methodologies for the probabilistic analysis of industrial accidents triggered by natural events (NA-TECH) on offshore oil platforms in the Italian seas, including extreme events related to climate changes. Furthermore the environmental effect of offshore activities has been investigated, including: changes on seismicity and on the evolution of coastal areas close to offshore platforms. Then a probabilistic multi-risk framework has been developed for the analysis of NA-TECH events on offshore installations for hydrocarbon extraction.

  8. Search for Gamma-Ray Bursts with the ARGO-YBJ Detector in Shower Mode

    NASA Astrophysics Data System (ADS)

    Bartoli, B.; Bernardini, P.; Bi, X. J.; Cao, Z.; Catalanotti, S.; Chen, S. Z.; Chen, T. L.; Cui, S. W.; Dai, B. Z.; D'Amone, A.; Danzengluobu; De Mitri, I.; D'Ettorre Piazzoli, B.; Di Girolamo, T.; Di Sciascio, G.; Feng, C. F.; Feng, Zhaoyang; Feng, Zhenyong; Gao, W.; Gou, Q. B.; Guo, Y. Q.; He, H. H.; Hu, Haibing; Hu, Hongbo; Iacovacci, M.; Iuppa, R.; Jia, H. Y.; Labaciren; Li, H. J.; Liu, C.; Liu, J.; Liu, M. Y.; Lu, H.; Ma, L. L.; Ma, X. H.; Mancarella, G.; Mari, S. M.; Marsella, G.; Mastroianni, S.; Montini, P.; Ning, C. C.; Perrone, L.; Pistilli, P.; Salvini, P.; Santonico, R.; Shen, P. R.; Sheng, X. D.; Shi, F.; Surdo, A.; Tan, Y. H.; Vallania, P.; Vernetto, S.; Vigorito, C.; Wang, H.; Wu, C. Y.; Wu, H. R.; Xue, L.; Yang, Q. Y.; Yang, X. C.; Yao, Z. G.; Yuan, A. F.; Zha, M.; Zhang, H. M.; Zhang, L.; Zhang, X. Y.; Zhang, Y.; Zhao, J.; Zhaxiciren; Zhaxisangzhu; Zhou, X. X.; Zhu, F. R.; Zhu, Q. Q.; ARGO-YBJ Collaboration

    2017-06-01

    The ARGO-YBJ detector, located at the Yangbajing Cosmic Ray Laboratory (4300 m a. s. l., Tibet, China), was a “full coverage” (central carpet with an active area of ˜93%) air shower array dedicated to gamma-ray astronomy and cosmic-ray studies. The wide field of view (˜2 sr) and high duty cycle (>86%), made ARGO-YBJ suitable to search for short and unexpected gamma-ray emissions like gamma-ray bursts (GRBs). Between 2007 November 6 and 2013 February 7, 156 satellite-triggered GRBs (24 of them with known redshift) occurred within the ARGO-YBJ field of view (zenith angle θ ≤ 45°). A search for possible emission associated with these GRBs has been made in the two energy ranges 10-100 GeV and 10-1000 GeV. No significant excess has been found in time coincidence with the satellite detections nor in a set of different time windows inside the interval of one hour after the bursts. Taking into account the EBL absorption, upper limits to the energy fluence at a 99% confidence level have been evaluated, with values ranging from ˜10-5 erg cm-2 to ˜10-1 erg cm-2. The Fermi-GBM burst GRB 090902B, with a high-energy photon of 33.4 GeV detected by Fermi-LAT, is discussed in detail.

  9. Argos: Princeton University's entry in the 2009 Intelligent Ground Vehicle Competition

    NASA Astrophysics Data System (ADS)

    Abiola, Solomon O.; Baldassano, Christopher A.; Franken, Gordon H.; Harris, Richard J.; Hendrick, Barbara A.; Mayer, Jonathan R.; Partridge, Brenton A.; Starr, Eric W.; Tait, Alexander N.; Yu, Derrick D.; Zhu, Tony H.

    2010-01-01

    In this paper, we present Argos, an autonomous ground robot built for the 2009 Intelligent Ground Vehicle Competition (IGVC). Discussed are the significant improvements over its predecessor from the 2008 IGVC, Kratos. We continue to use stereo vision techniques to generate a cost map of the environment around the robot. Lane detection is improved through the use of color filters that are robust to changing lighting conditions. The addition of a single-axis gyroscope to the sensor suite allows accurate measurement of the robot's yaw rate and compensates for wheel slip, vastly improving state estimation. The combination of the D* Lite algorithm, which avoids unnecessary re-planning, and the Field D* algorithm, which allows us to plan much smoother paths, results in an algorithm that produces higher quality paths in the same amount of time as methods utilizing A*. The successful implementation of a crosstrack error navigation law allows the robot to follow planned paths without cutting corners, reducing the chance of collision with obstacles. A redesigned chassis with a smaller footprint and a bi-level design, combined with a more powerful drivetrain, makes Argos much more agile and maneuverable compared to its predecessor. At the 2009 IGVC, Argos placed first in the Navigation Challenge.

  10. The use of Argo for validation and tuning of mixed layer models

    NASA Astrophysics Data System (ADS)

    Acreman, D. M.; Jeffery, C. D.

    We present results from validation and tuning of 1-D ocean mixed layer models using data from Argo floats and data from Ocean Weather Station Papa (145°W, 50°N). Model tests at Ocean Weather Station Papa showed that a bulk model could perform well provided it was tuned correctly. The Large et al. [Large, W.G., McWilliams, J.C., Doney, S.C., 1994. Oceanic vertical mixing: a review and a model with a nonlocal boundary layer parameterisation. Rev. Geophys. 32 (Novermber), 363-403] K-profile parameterisation (KPP) model also gave a good representation of mixed layer depth provided the vertical resolution was sufficiently high. Model tests using data from a single Argo float indicated a tendency for the KPP model to deepen insufficiently over an annual cycle, whereas the tuned bulk model and general ocean turbulence model (GOTM) gave a better representation of mixed layer depth. The bulk model was then tuned using data from a sample of Argo floats and a set of optimum parameters was found; these optimum parameters were consistent with the tuning at OWS Papa.

  11. SMOS validation using SSS data from Barcelona World Race and Argo profilers

    NASA Astrophysics Data System (ADS)

    Umbert, M.; Ballabrera, J.; Fernandez, P.; Salat, J.; Salvador, J.

    2012-04-01

    The organisers of the Barcelona World Race (BWR), the Institute of Marine Sciences (ICM-CSIC) and the Maritime Catalan Forum (FMC) agreed on equiping the FMC boat, participating in the race, with a SeaBird MiniCTD. The idea was for the first time to explore how such oceanic races could help to monitor surface temperature and salinity all around the world ocean in real time. The boat spent 112 days to complete the rond trip, sending 12-30 real-time samples/day via ARGOS satellites, using a transmitter developed at the ICM. Data was also stored in the instrument, at 192 samples/day to allow further final global analyses. In the SMOS (Soil Moisture and Ocean Salinity) satellite mission processing chain, sea surface salinity (SSS) values are retrieved from brightness temperature data at level 2 (L2). Global maps of SSS are being generated at level 3 (L3) using spatial and temporal weighted averages. Finally, improved representations of the SSS field are obtained at level 4 (L4) where satellite data is blended with data from other sensors. In the present study, validation of L2, L3 and L4 products using data from BWR and ARGO buoys is presented, covering the race period from January to April 2011. Differences between these two sets of data are also investigated as the uppermost robust measurements from Argo profilers have larger depths than the ones associated to the BWR boat.

  12. Status report on the Large Binocular Telescope's ARGOS ground-layer AO system

    NASA Astrophysics Data System (ADS)

    Hart, M.; Rabien, S.; Busoni, L.; Barl, L.; Beckmann, U.; Bonaglia, M.; Boose, Y.; Borelli, J. L.; Bluemchen, T.; Carbonaro, L.; Connot, C.; Deysenroth, M.; Davies, R.; Durney, O.; Elberich, M.; Ertl, T.; Esposito, S.; Gaessler, W.; Gasho, V.; Gemperlein, H.; Hubbard, P.; Kanneganti, S.; Kulas, M.; Newman, K.; Noenickx, J.; Orban de Xivry, G.; Peter, D.; Quirrenbach, A.; Rademacher, M.; Schwab, C.; Storm, J.; Vaitheeswaran, V.; Weigelt, G.; Ziegleder, J.

    2011-10-01

    ARGOS, the laser-guided adaptive optics system for the Large Binocular Telescope (LBT), is now under construction at the telescope. By correcting atmospheric turbulence close to the telescope, the system is designed to deliver high resolution near infrared images over a field of 4 arc minute diameter. Each side of the LBT is being equipped with three Rayleigh laser guide stars derived from six 18 W pulsed green lasers and projected into two triangular constellations matching the size of the corrected field. The returning light is to be detected by wavefront sensors that are range gated within the seeing-limited depth of focus of the telescope. Wavefront correction will be introduced by the telescope's deformable secondary mirrors driven on the basis of the average wavefront errors computed from the respective guide star constellation. Measured atmospheric turbulence profiles from the site lead us to expect that by compensating the ground-layer turbulence, ARGOS will deliver median image quality of about 0.2 arc sec across the JHK bands. This will be exploited by a pair of multi-object near-IR spectrographs, LUCIFER1 and LUCIFER2, with 4 arc minute field already operating on the telescope. In future, ARGOS will also feed two interferometric imaging instruments, the LBT Interferometer operating in the thermal infrared, and LINC-NIRVANA, operating at visible and near infrared wavelengths. Together, these instruments will offer very broad spectral coverage at the diffraction limit of the LBT's combined aperture, 23 m in size.

  13. Geophysical investigations near the ancient Agora at the city of Argos, Greece

    NASA Astrophysics Data System (ADS)

    Zananiri, Irene; Hademenos, Vassilios; Piteros, Christos

    2010-06-01

    It is possible to reduce risk in archaeological excavations by identifying areas of high potential at an early stage and locating trenches accordingly. Towards this goal, a non-invasive geophysical survey was carried out at the city of Argos, which from the beginning of Archaic Times and through to Classical Times was one of the most prominent city-states. Based on historical and archaeological evidence, two sites were chosen near the ancient Agora of Argos. Total field and gradient magnetic measurements were collected over several grids, with 1 m spacing between measurement points. Representative samples were taken for laboratory measurements of the low-field magnetic susceptibility. Mapping, filtering and inversion procedures of the magnetic data have been used in tandem. The data management and cartographic representation was performed using Geographic Information Systems, where a geographic database was created, including all available information for the broader Argos area. The results of the geophysical survey were able to highlight the presence of linear and square structures possibly representing inhabitance ruins, namely small building remnants and road foundations according to observations from neighbouring excavations. Thus, the authors were able to suggest to the archaeologists excavation tests on the basis of the residual magnetic map.

  14. Mixed Layer Depth Seasonality within the Coral Sea Based on Argo Data

    PubMed Central

    Jaffrés, Jasmine B. D.

    2013-01-01

    The worldwide deployment of Argo floats has enabled much more detailed studies of global and regional seas over the last decade. Here, the seasonal variability of the mixed layer depth (MLD) within the Coral Sea was examined with CTD profiles from Argo floats. Multiple threshold values for both temperature and density have been employed to determine the most suitable threshold values for the Coral Sea. A threshold value of 0.04 kg/m3 for density and 0.2°C for temperature appear the most fitting for this region. Although MLD and isothermal layer depth (ILD) coincide quite well in most cases, the relatively common presence of temporary, non-seasonal barrier layers induces an ILD that is significantly deeper than the MLD. Consequently, an MLD estimation based on density is more appropriate. A distinct seasonality in the MLD is evident throughout the Coral Sea, but is generally more pronounced in higher southern latitudes (20–30°S). Salinity inversions are rare and mainly occur in the south-eastern Coral Sea, while barrier layers are more commonly associated with the north-eastern Coral Sea, a region characterised by high rainfall. The significance of regional currents is evident in the north-western Coral Sea, where temperature and ocean heat content is relatively low due to a northward moving boundary current. Shallow bathymetry, in turn, is linked to the absence of Argo data on the continental shelf and in the central Coral Sea. PMID:23593368

  15. Study of the Diffuse Gamma-Ray Emission from the Galactic Plane with ARGO-YBJ

    NASA Astrophysics Data System (ADS)

    Bartoli, B.; Bernardini, P.; Bi, X. J.; Branchini, P.; Budano, A.; Camarri, P.; Cao, Z.; Cardarelli, R.; Catalanotti, S.; Chen, S. Z.; Chen, T. L.; Creti, P.; Cui, S. W.; Dai, B. Z.; D'Amone, A.; Danzengluobu; De Mitri, I.; D'Ettorre Piazzoli, B.; Di Girolamo, T.; Di Sciascio, G.; Feng, C. F.; Feng, Zhaoyang; Feng, Zhenyong; Gou, Q. B.; Guo, Y. Q.; He, H. H.; Hu, Haibing; Hu, Hongbo; Iacovacci, M.; Iuppa, R.; Jia, H. Y.; Labaciren; Li, H. J.; Liguori, G.; Liu, C.; Liu, J.; Liu, M. Y.; Lu, H.; Ma, L. L.; Ma, X. H.; Mancarella, G.; Mari, S. M.; Marsella, G.; Martello, D.; Mastroianni, S.; Montini, P.; Ning, C. C.; Panareo, M.; Perrone, L.; Pistilli, P.; Ruggieri, F.; Salvini, P.; Santonico, R.; Shen, P. R.; Sheng, X. D.; Shi, F.; Surdo, A.; Tan, Y. H.; Vallania, P.; Vernetto, S.; Vigorito, C.; Wang, H.; Wu, C. Y.; Wu, H. R.; Xue, L.; Yang, Q. Y.; Yang, X. C.; Yao, Z. G.; Yuan, A. F.; Zha, M.; Zhang, H. M.; Zhang, L.; Zhang, X. Y.; Zhang, Y.; Zhao, J.; Zhaxiciren; Zhaxisangzhu; Zhou, X. X.; Zhu, F. R.; Zhu, Q. Q.; Zizzi, G.; ARGO-YBJ Collaboration

    2015-06-01

    The events recorded by ARGO-YBJ in more than five years of data collection have been analyzed to determine the diffuse gamma-ray emission in the Galactic plane at Galactic longitudes 25° < l < 100° and Galactic latitudes |b|\\lt 5{}^\\circ . The energy range covered by this analysis, from ˜350 GeV to ˜2 TeV, allows the connection of the region explored by Fermi with the multi-TeV measurements carried out by Milagro. Our analysis has been focused on two selected regions of the Galactic plane, i.e., 40° < l < 100° and 65° < l < 85° (the Cygnus region), where Milagro observed an excess with respect to the predictions of current models. Great care has been taken in order to mask the most intense gamma-ray sources, including the TeV counterpart of the Cygnus cocoon recently identified by ARGO-YBJ, and to remove residual contributions. The ARGO-YBJ results do not show any excess at sub-TeV energies corresponding to the excess found by Milagro, and are consistent with the predictions of the Fermi model for the diffuse Galactic emission. From the measured energy distribution we derive spectral indices and the differential flux at 1 TeV of the diffuse gamma-ray emission in the sky regions investigated.

  16. Development of U-Mart System with Plural Brands and Plural Markets

    NASA Astrophysics Data System (ADS)

    Akimoto, Yoshihito; Mori, Naoki; Ono, Isao; Nakajima, Yoshihiro; Kita, Hajime; Matsumoto, Keinosuke

    In this paper, we first discuss the notion that artificial market systems should meet the requirements of fidelity, transparency, reproducibility, and traceability. Next, we introduce history of development of the artificial market system named U-Mart system that meet the requirements well, which have been developed by the U-Mart project. We have already developed the U-Mart system called “U-Mart system version 3.0” to solve problems of old U-Mart systems. In version 3.0 system, trading process is modularized and universal market system can be easily introduced.
    However, U-Mart system version 3.0 only simulates the single brand futures market. The simulation of the plural brands and plural markets has been required by lot of users. In this paper, we proposed a novel U-Mart system called “U-Mart system version 4.0” to solve this problem of U-Mart system version 3.0. We improve the server system, machine agents and GUI in order to simulate plural brands and plural markets in U-Mart system version 4.0. The effectiveness of the proposed system is confirmed by statistical analysis of results of spot market simulation with random agents.

  17. Caño Martín Peña (Martín Peña Channel, Puerto Rico)

    EPA Pesticide Factsheets

    The Martín Peña Channel Urban Waters Federal Partnership seeks to make significant contributions to the health and welfare of the eight communities that surround the Martín Peña Channel in San Juan, Puerto Rico.

  18. The "Martes complex"-- an opportunity to bring together marten, fisher, sable, wolverine, and tayra biologists

    Treesearch

    Gilbert Proulx; Keith B. Aubry

    2014-01-01

    Recent phylogenetic studies have shown that the genus Martes is polyphyletic with respect to the Fisher (Pekania pennanti), which is more closely related to the Wolverine (Gulo gulo) and Tayra (Eira barbara) than it is to the martens. We refer to the 11 species in the genera Martes, Pekania, Gulo, and Eira as the “Martes Complex”. Because the species comprising the...

  19. Design and implementation of fishery rescue data mart system

    NASA Astrophysics Data System (ADS)

    Pan, Jun; Huang, Haiguang; Liu, Yousong

    A novel data mart based system for fishery rescue field was designed and implemented. The system runs ETL process to deal with original data from various databases and data warehouses, and then reorganized the data into the fishery rescue data mart. Next, online analytical processing (OLAP) are carried out and statistical reports are generated automatically. Particularly, quick configuration schemes are designed to configure query dimensions and OLAP data sets. The configuration file will be transformed into statistic interfaces automatically through a wizard-style process. The system provides various forms of reporting files, including crystal reports, flash graphical reports, and two-dimensional data grids. In addition, a wizard style interface was designed to guide users customizing inquiry processes, making it possible for nontechnical staffs to access customized reports. Characterized by quick configuration, safeness and flexibility, the system has been successfully applied in city fishery rescue department.

  20. Molecular identification of Trichinella britovi in martens (Martes martes) and badgers (Meles meles); new host records in Poland.

    PubMed

    Moskwa, Bożena; Goździk, Katarzyna; Bień, Justyna; Bogdaszewski, Marek; Cabaj, Władysław

    2012-12-01

    Trichinella larvae were detected in a marten (Martes martes) and a badger (Meles meles) in Poland. The animals were found dead following car accidents. All examined animals derived from the Mazurian Lake district, north-east Poland, near the village Kosewo Górne where Trichinella infection were earlier confirmed in wildlife; red foxes and wild boars. The muscle samples were examined by artificial pepsin-HCl digestion method. The parasites were identified as Trichinella britovi by multiplex polymerase chain reaction method. Larvae were found in two out of three martens and one out of seven examined badgers. This is the first report of the identification of Trichinella britovi larvae from martens and badgers in Poland.

  1. Trichinella britovi biomass in naturally infected pine martens (Martes martes) of Latvia.

    PubMed

    Kirjušina, Muza; Bakasejevs, Eduards; Pezzotti, Patrizio; Pozio, Edoardo

    2016-11-15

    Parasites of the genus Trichinella are cosmopolitan nematodes infecting primarily wild animals, which represent the main reservoirs of these zoonotic pathogens. To investigate the transmission patterns of Trichinella spp. from wild to domestic animals and to humans and for the risk assessment of these parasites in a geographical area, it is important to know the number of possible transmission events deriving from carcasses of infected hosts. For this purpose, the evaluation of the larval biomass in reservoir hosts is needed. No data is available on how to estimate the biomass of Trichinella spp. larvae in muscles of naturally infected animals. The aim of this study was to evaluate the larval biomass in naturally infected pine martens (Martes martes) of Latvia, in which the prevalence of Trichinella britovi infection was over 50%. Single muscles or group of muscles (abdomen, back, diaphragm, intercostal muscles, muscles from the head, left and right shoulders, lower and upper parts of the forelimbs and hind limbs, neck, rump with tail, and base and tip of the tongue) were collected from five skinned and eviscerated carcasses of T. britovi infected pine martens. Muscles were entirely removed from the bones and weighted. Each muscle or group of muscles was separately digested to detect the larvae per gram (LPG). Using linear regression, the larval burden in each muscle or group of muscles was evaluated to measure the possible prediction of the total animal larval burden (both as total number of larvae and as average LPG). All muscles were significantly predictive of the total burden with high "goodness of fit" (all adjusted R2>0.80; P≤0.01), and the left shoulder provided the highest adjusted R2 (0.999). Then, to estimate the Trichinella britovi biomass in the pine marten population of Latvia, recent literature data on prevalence (56.2%, 95% CI: 47.8-64.3) and geometric mean LPG (1.26, 95% CI: 0.89-1.79) in the limb muscles of a sample representative of the whole

  2. Evaluation of Argos Telemetry Accuracy in the High-Arctic and Implications for the Estimation of Home-Range Size.

    PubMed

    Christin, Sylvain; St-Laurent, Martin-Hugues; Berteaux, Dominique

    2015-01-01

    Animal tracking through Argos satellite telemetry has enormous potential to test hypotheses in animal behavior, evolutionary ecology, or conservation biology. Yet the applicability of this technique cannot be fully assessed because no clear picture exists as to the conditions influencing the accuracy of Argos locations. Latitude, type of environment, and transmitter movement are among the main candidate factors affecting accuracy. A posteriori data filtering can remove "bad" locations, but again testing is still needed to refine filters. First, we evaluate experimentally the accuracy of Argos locations in a polar terrestrial environment (Nunavut, Canada), with both static and mobile transmitters transported by humans and coupled to GPS transmitters. We report static errors among the lowest published. However, the 68th error percentiles of mobile transmitters were 1.7 to 3.8 times greater than those of static transmitters. Second, we test how different filtering methods influence the quality of Argos location datasets. Accuracy of location datasets was best improved when filtering in locations of the best classes (LC3 and 2), while the Douglas Argos filter and a homemade speed filter yielded similar performance while retaining more locations. All filters effectively reduced the 68th error percentiles. Finally, we assess how location error impacted, at six spatial scales, two common estimators of home-range size (a proxy of animal space use behavior synthetizing movements), the minimum convex polygon and the fixed kernel estimator. Location error led to a sometimes dramatic overestimation of home-range size, especially at very local scales. We conclude that Argos telemetry is appropriate to study medium-size terrestrial animals in polar environments, but recommend that location errors are always measured and evaluated against research hypotheses, and that data are always filtered before analysis. How movement speed of transmitters affects location error needs

  3. Evaluation of Argos Telemetry Accuracy in the High-Arctic and Implications for the Estimation of Home-Range Size

    PubMed Central

    Christin, Sylvain; St-Laurent, Martin-Hugues; Berteaux, Dominique

    2015-01-01

    Animal tracking through Argos satellite telemetry has enormous potential to test hypotheses in animal behavior, evolutionary ecology, or conservation biology. Yet the applicability of this technique cannot be fully assessed because no clear picture exists as to the conditions influencing the accuracy of Argos locations. Latitude, type of environment, and transmitter movement are among the main candidate factors affecting accuracy. A posteriori data filtering can remove “bad” locations, but again testing is still needed to refine filters. First, we evaluate experimentally the accuracy of Argos locations in a polar terrestrial environment (Nunavut, Canada), with both static and mobile transmitters transported by humans and coupled to GPS transmitters. We report static errors among the lowest published. However, the 68th error percentiles of mobile transmitters were 1.7 to 3.8 times greater than those of static transmitters. Second, we test how different filtering methods influence the quality of Argos location datasets. Accuracy of location datasets was best improved when filtering in locations of the best classes (LC3 and 2), while the Douglas Argos filter and a homemade speed filter yielded similar performance while retaining more locations. All filters effectively reduced the 68th error percentiles. Finally, we assess how location error impacted, at six spatial scales, two common estimators of home-range size (a proxy of animal space use behavior synthetizing movements), the minimum convex polygon and the fixed kernel estimator. Location error led to a sometimes dramatic overestimation of home-range size, especially at very local scales. We conclude that Argos telemetry is appropriate to study medium-size terrestrial animals in polar environments, but recommend that location errors are always measured and evaluated against research hypotheses, and that data are always filtered before analysis. How movement speed of transmitters affects location error needs

  4. Argo data assimilation into HYCOM with an EnOI method in the Atlantic Ocean

    NASA Astrophysics Data System (ADS)

    Mignac, D.; Tanajura, C. A. S.; Santana, A. N.; Lima, L. N.; Xie, J.

    2015-02-01

    An ocean data assimilation system to assimilate Argo temperature (T) and salinity (S) profiles into the HYbrid Coordinate Ocean Model (HYCOM) was constructed, implemented and evaluated for the first time in the Atlantic Ocean (78° S to 50° N and 98° W to 20° E). The system is based on the ensemble optimal interpolation (EnOI) algorithm proposed by Xie and Zhu (2010), especially made to deal with the hybrid nature of the HYCOM vertical coordinate system with multiple steps. The Argo T-S profiles were projected to the model vertical space to create pseudo-observed layer thicknesses (Δ pobs), which correspond to the model target densities. The first step was to assimilate Δ pobs considering the sub-state vector composed by the model layer thickness (Δ p) and the baroclinic velocity components. After that, T and S were assimilated separately. Finally, T was diagnosed below the mixed layer to preserve the density of the model isopycnal layers. Five experiments were performed from 1 January 2010 to 31 December 2012: a control run without assimilation, and four assimilation runs considering the different vertical localizations of T, S and Δ p. The assimilation experiments were able to significantly improve the thermohaline structure produced by the control run. They reduced the root mean square deviation (RMSD) of T and S calculated with respect to Argo independent data in 34 and 44%, respectively, in comparison to the control run. In some regions, such as the western North Atlantic, substantial corrections in the 20 °C isotherm depth and the upper ocean heat content towards climatological states were achieved. The runs with a vertical localization of Δ p showed positive impacts in the correction of the thermohaline structure and reduced the RMSD of T (S) from 0.993 °C (0.149 psu) to 0.905 °C (0.138 psu) for the whole domain with respect to the other assimilation runs.

  5. Coherent heat patterns revealed by unsupervised classification of Argo temperature profiles in the North Atlantic Ocean

    NASA Astrophysics Data System (ADS)

    Maze, Guillaume; Mercier, Herlé; Fablet, Ronan; Tandeo, Pierre; Lopez Radcenco, Manuel; Lenca, Philippe; Feucher, Charlène; Le Goff, Clément

    2017-02-01

    A quantitative understanding of the integrated ocean heat content depends on our ability to determine how heat is distributed in the ocean and identify the associated coherent patterns. This study demonstrates how this can be achieved using unsupervised classification of Argo temperature profiles. The classification method used is a Gaussian Mixture Model (GMM) that decomposes the Probability Density Function of a dataset into a weighted sum of Gaussian modes. It is determined that the North Atlantic Argo dataset of temperature profiles contains 8 groups of vertically coherent heat patterns, or classes. Each of the temperature profile classes reveals unique and physically coherent heat distributions along the vertical axis. A key result of this study is that, when mapped in space, each of the 8 classes is found to define an oceanic region, even if no spatial information was used in the model determination. The classification result is independent of the location and time of the ARGO profiles. Two classes show cold anomalies throughout the water column with amplitude decreasing with depth. They are found to be localized in the subpolar gyre and along the poleward flank of the Gulf Stream and North Atlantic Current (NAC). One class has nearly zero anomalies and a large spread throughout the water column. It is found mostly along the NAC. One class has warm anomalies near the surface (50 m) and cold ones below 200 m. It is found in the tropical/equatorial region. The remaining four classes have warm anomalies throughout the water column, one without depth dependance (in the southeastern part of the subtropical gyre), the other three with clear maximums at different depths (100 m, 400 m and 1000 m). These are found along the southern flank of the North Equatorial Current, the western part of the subtropical gyre and over the West European Basin. These results are robust to both the seasonal variability and to method parameters such as the size of the analyzed domain.

  6. A prototype of an adjustable advanced reciprocating gait orthosis (ARGO) for spinal cord injury (SCI).

    PubMed

    Scivoletto, G; Mancini, M; Fiorelli, E; Morganti, B; Molinari, M

    2003-03-01

    To develop a reciprocating gait orthosis which could be used in different sized patients. Clinical trial and orthotic development. A large rehabilitation hospital in Rome, Italy To carry out this project normal reciprocating gait orthosis parts were used. The device was modified to adjust the hip-ankle height, and the hip-hip distance. It was tested, by five patients already walking with standard ARGO, to evaluate the performances of the orthosis. The device has been tested on seven newly injured patients fulfilling specific criteria of different height and weight. Prototype suitability; patients appreciation. The device can be used for persons between 1.60 m and 1.85 m tall, weighing up to 100 kg. The orthosis allows an upright position without the use of the hands, and walking with a walker or with two canes. The foot orthosis cover sizes 36-40 (British 3-7) and 41-45 (British 7-11). With the exception of donning, doffing and lifting, the walking performances of the prototype and the general appreciation is comparable with those of a standard device. After a short period of training all seven patients were able to walk in the parallel bars. All of them expressed general appreciation for the device; despite this only four patients wanted the orthosis, two refused it and one has not decided yet. The prototype allows the same standing and walking performances of normal ARGO. It could be used in spinal cord injury patients to let them test the potential of the device and thus be useful in the effort to reduce the percentage of ARGO rejection.

  7. Argo data assimilation into HYCOM with an EnOI method in the Atlantic Ocean

    NASA Astrophysics Data System (ADS)

    Mignac, D.; Tanajura, C. A. S.; Santana, A. N.; Lima, L. N.; Xie, J.

    2014-07-01

    An ocean data assimilation system to assimilate Argo temperature (T) and salinity (S) profiles into HYCOM was constructed, implemented and evaluated for the first time in the Atlantic Ocean (78° S to 50° N and 98° W to 20° E). The system is based on the Ensemble Optimal Interpolation (EnOI) algorithm proposed by Xie and Zhu (2010), especially made to deal with the hybrid nature of HYCOM vertical coordinate system with multiple steps. The Argo T/S profiles were projected to the model vertical space to create pseudo-observed layer thicknesses (Δ pobs) which correspond to the model target densities. The first step was to assimilate Δ pobs considering the sub-state vector composed by the model layer thickness (Δ p) and the baroclinic velocity components. After that, T and S were assimilated separately. At last, T was diagnosed below the mixed layer to preserve the density of the model isopycnal layers. Five experiments were performed from 1 January 2010 until 31 December 2012: a control run without assimilation, and four assimilation runs considering different vertical localizations of T, S and Δ p. The assimilation experiments were able to significantly improve the thermohaline structure produced by the control run. They reduced the RMSD of T (S) calculated with respect to Argo independent data in 34.11% (43.56%) in comparison to the control run. In some regions, such as the west North Atlantic, substantial corrections in the 20 °C isotherm depth and the upper ocean heat content towards climatological states were achieved. The runs with vertical localization of Δ p showed positive impacts in the correction of the thermohaline structure and reduced the RMSD of T (S) from 0.993 °C (0.149 psu) to 0.905 °C (0.138 psu) for the whole domain with respect to the other assimilation runs.

  8. Circumpolar Estimates of Isopycnal Mixing in the ACC from Argo Floats

    NASA Astrophysics Data System (ADS)

    Roach, C. J.; Balwada, D.; Speer, K. G.

    2015-12-01

    There are few direct observations of cross-stream isopycnal mixing in the interior of the Southern Ocean, yet such measurements are needed to determine the role of eddies transporting properties across the ACC, and key to progress toward testing theories of meridional overturning. In light of this we examine if it is possible to obtain estimates of mixing from Argo float trajectories. We divided the Southern Ocean into overlapping 15ο longitude bins before estimating mixing. Resulting diffusivities ranged from 300 to 3000 m2s-1, with peaks corresponding to the Scotia Sea; Kerguelen and Campbell Plateaus. Comparison of our diffusivities with previous regional studies demonstrated good agreement. Tests of the methodology in the DIMES region found that mixing from Argo floats agreed closely with mixing from RAFOS floats. To further test the method we used the Southern Ocean State Estimate velocity fields to advect particles with Argo and RAFOS float like behaviours. Stirring estimates from the particles agreed well with each other in the Kerguelen Island region, South Pacific and Scotia Sea, despite the differences in the imposed behaviour. Finally, these estimates were compared to mixing length suppression theory presented in Ferrari and Nikurashin 2010. This mixing length suppression theory quantifies horizontal diffusivity similar to Prandtl (1925), but the mixing length is suppressed in the presence of mean flows and eddy phase speeds. Our results suggest that the theory can explain both the structure and magnitude of mixing using mean flow data. An exception is near the Kerguelen and Campbell Plateaus where theory under-estimates mixing relative to our results.

  9. Mapping error in Southern Ocean transport computed from satellite altimetry and argo

    NASA Astrophysics Data System (ADS)

    Kosempa, Michael; Chambers, Don P.

    2016-11-01

    In an effort to better estimate transport dynamics in response to wind forcing (primarily the Southern Annual Mode), this study quantifies the uncertainty in mapping zonal geostrophic transport of the Antarctic Circumpolar Current from sparse temperature, salinity and sea surface height observations. To do this, we sampled an ocean state estimate at the locations of both Argo floats and the Jason-1 altimeter groundtrack. These sampled values were then optimally interpolated to create SSH and temperature/salinity grids with 1° resolution. The temperature, salinity and SSH grids were then combined to compute the zonal geostrophic transport and compared to that estimated from the full state estimate. There are significant correlations between the baroclinic and barotropic error contributions to the total transport error. The increase in Argo floats in the Southern Ocean is effective in reducing mapping error. However, that error improvement is not uniform. By analyzing systematic errors in transport time series, we find the transects that are most appropriate for analyzing the dynamics of ACC transport using Argo and altimetric gridded fields. Based on our analysis, we conclude region south of Tasmania is most appropriate, with lowest uncertainty. Using real-world data, we calculated zonal transport variability at a transect south of Tasmania. There is an insignificant trend (0.3 ± 0.4 Sv yr-1, 90% confidence) but significant low-frequency variability correlated with the Southern Annular Mode (0.53, p < 0.05). The barotropic component is most responsible for the low-frequency variability, and this would be unobservable from ship casts without velocity measurements at depth.

  10. The ARGOS laser system: green light for ground layer adaptive optics at the LBT

    NASA Astrophysics Data System (ADS)

    Raab, Walfried; Rabien, Sebastian; Gässler, Wolfgang; Esposito, Simone; Barl, Lothar; Borelli, Jose; Daysenroth, Matthias; Gemperlein, Hans; Kulas, Martin; Ziegleder, Julian

    2014-07-01

    We report on the development of the laser system of ARGOS, the multiple laser guide star adaptive optics system for the Large Binocular Telescope (LBT). The system uses a total of six high powered, pulsed Nd:YAG lasers frequency-doubled to a wavelength of 532 nm to generate a set of three guide stars above each of the LBT telescopes. The position of each of the LGS constellations on sky as well as the relative position of the individual laser guide stars within this constellation is controlled by a set of steerable mirrors and a fast tip-tilt mirror within the laser system. The entire opto-mechanical system is housed in two hermetically sealed and thermally controlled enclosures on the SX and DX side of the LBT telescope. The laser beams are propagated through two refractive launch telescopes which focus the beams at an altitude of 12 km, creating a constellation of laser guide stars around a 4 arcminute diameter circle by means of Rayleigh scattering. In addition to the GLAO Rayleigh beacon system, ARGOS has also been designed for a possible future upgrade with a hybrid sodium laser - Rayleigh beacon combination, enabling diffraction limited operation. The ARGOS laser system was successfully installed at the LBT in April 2013. Extensive functional tests have been carried out and have verified the operation of the systems according to specifications. The alignment of the laser system with respect to the launch telescope was carried out during two more runs in June and October 2013, followed by the first propagation of laser light on sky in November 2013.

  11. The Argo simulation - II. The early build-up of the Hubble sequence

    NASA Astrophysics Data System (ADS)

    Fiacconi, Davide; Feldmann, Robert; Mayer, Lucio

    2015-01-01

    The Hubble sequence is a common classification scheme for the structure of galaxies. Despite the tremendous usefulness of this diagnostic, we still do not fully understand when, where, and how this morphological ordering was put in place. Here, we investigate the morphological evolution of a sample of 22 high-redshift (z ≥ 3) galaxies extracted from the Argo simulation. Argo is a cosmological zoom-in simulation of a group-sized halo and its environment. It adopts the same high-resolution (˜104 M⊙, ˜100 pc) and sub-grid physical model that was used in the Eris simulation but probes a sub-volume almost 10 times bigger with as many as 45 million gas and star particles in the zoom-in region. Argo follows the early assembly of galaxies with a broad range of stellar masses (log M⋆/M⊙ ˜ 8-11 at z ≃ 3), while resolving properly their structural properties. We recover a diversity of morphologies, including late-type/irregular disc galaxies with flat rotation curves, spheroid dominated early-type discs, and a massive elliptical galaxy, already established at z ˜ 3. We identify major mergers as the main trigger for the formation of bulges and the steepening of the circular velocity curves. Minor mergers and non-axisymmetric perturbations (stellar bars) drive the bulge growth in some cases. The specific angular momenta of the simulated disc components fairly match the values inferred from nearby galaxies of similar M⋆ once the expected redshift evolution of disc sizes is accounted for. We conclude that morphological transformations of high-redshift galaxies of intermediate mass are likely triggered by processes similar to those at low redshift and result in an early build-up of the Hubble sequence.

  12. Diffraction-limited upgrade to ARGOS: the LBT's ground-layer adaptive optics system

    NASA Astrophysics Data System (ADS)

    Hart, Michael; Busoni, Lorenzo; Durney, Olivier; Esposito, Simone; Gässler, Wolfgang; Gasho, Victor; Rabien, Sebastian; Rademacher, Matt

    2010-07-01

    The Large Binocular Telescope (LBT) is now operating with the first of two permanently installed adaptive secondary mirrors, and the first of two complementary near-IR instruments called LUCIFER is operational as well. The ARGOS laser-guided ground-layer adaptive optics (GLAO) system, described elsewhere at this conference1, will build on this foundation to deliver the highest resolution over the 4 arc min wide-field imaging and multi-object spectroscopic modes of LUCIFER. In this paper, we describe a planned upgrade to ARGOS which will supplement the Rayleigh-based GLAO system with sodium laser guide stars (LGS) to fulfill the telescope's diffraction-limited potential. In its narrow-field mode of 30 arc sec, LUCIFER will deliver imaging at the Nyquist limit of the individual 8.4 m apertures down to J band and long-slit spectroscopy with resolution up to 40,000. In addition, the LBT Interferometer2 (LBTI) will cophase the two apertures, offering imaging at the diffraction limit of the 22.8 m baseline at wavelengths from 1.2 to 20 μm. In the first phase of the upgrade, a 10 W sodium LGS will be added to each half of the LBT, using the same launch telescopes mounted behind the two secondary mirrors as the Rayleigh LGS. The upgrade will rely on other components of the ARGOS infrastructure such as acquisition and guiding, and fast tip-tilt cameras. New wavefront sensors will be added to LUCIFER and LBTI. In the upgrade's second phase, the sodium and Rayleigh LGS will be used together in a hybrid tomographic sensing system. This configuration will offer the advantage that a single tip-tilt star will continue to be sufficient even for MCAO operation3, which is planned with LBT's LINC-NIRVANA instrument4,5.

  13. 135 years of global ocean warming between the Challenger expedition and the Argo Programme

    NASA Astrophysics Data System (ADS)

    Roemmich, Dean; John Gould, W.; Gilson, John

    2012-06-01

    Changing temperature throughout the oceans is a key indicator of climate change. Since the 1960s about 90% of the excess heat added to the Earth's climate system has been stored in the oceans. The ocean's dominant role over the atmosphere, land, or cryosphere comes from its high heat capacity and ability to remove heat from the sea surface by currents and mixing. The longest interval over which instrumental records of subsurface global-scale temperature can be compared is the 135 years between the voyage of HMS Challenger (1872-1876) and the modern data set of the Argo Programme (2004-2010). Argo's unprecedented global coverage permits its comparison with any earlier measurements. This, the first global-scale comparison of Challenger and modern data, shows spatial mean warming at the surface of 0.59°C+/-0.12, consistent with previous estimates of globally averaged sea surface temperature increase. Below the surface the mean warming decreases to 0.39°C+/-0.18 at 366m (200fathoms) and 0.12°C+/-0.07 at 914m (500fathoms). The 0.33°C+/-0.14 average temperature difference from 0 to 700m is twice the value observed globally in that depth range over the past 50 years, implying a centennial timescale for the present rate of global warming. Warming in the Atlantic Ocean is stronger than in the Pacific. Systematic errors in the Challenger data mean that these temperature changes are a lower bound on the actual values. This study underlines the scientific significance of the Challenger expedition and the modern Argo Programme and indicates that globally the oceans have been warming at least since the late-nineteenth or early-twentieth century.

  14. An argo-based model for investigation of the Global Ocean (AMIGO)

    NASA Astrophysics Data System (ADS)

    Lebedev, K. V.

    2016-03-01

    We analyze the newly developed Argo-Based Model for Investigation of the Global Ocean (AMIGO), which consists of a block for variational interpolation of the profiles of drifting Argo floats to a regular grid and a block for model hydrodynamic adjustment of variationally interpolated fields. Such a method makes it possible to obtain a full set of oceanographic characteristics—temperature, salinity, density, and current velocity—using irregularly located Argo measurements. The resulting simulations are represented as monthly mean, seasonal, and annual means and climatological fields. The AMIGO oceanographic database developed at the Shirshov Institute of Oceanology from model simulations covers the 10-year period from 2005 to 2014. Analysis of transport variations in the propagation of North Atlantic Current jets to the Arctic based on the AMIGO data showed that during this period, anomalous winter transports were observed, which correlate with anomalous winter temperatures in regions of northwestern Europe, northern European Russia, and Iceland, which are subjected to the influence of these currents. Comparative analysis of variations in mass and heat transport by the currents and the North Atlantic Oscillation (NAO) index in the period of 2005-2014 shows a well pronounced correlation between them. The low winter values of the NAO index correspond to the low values of winter transports by the Faroe-Shetland branch of the North Atlantic current, and usually, to the high values of winter transports by the North Icelandic branch of the Irminger Current. High winter value of the NAO index results in a substantial increase in the winter transport by the Faroe-Shetland branch of the North Atlantic Current without notable influence on the transport of the North Icelandic branch of the Irminger Current.

  15. Argo: enabling the development of bespoke workflows and services for disease annotation

    PubMed Central

    Batista-Navarro, Riza; Carter, Jacob; Ananiadou, Sophia

    2016-01-01

    Argo (http://argo.nactem.ac.uk) is a generic text mining workbench that can cater to a variety of use cases, including the semi-automatic annotation of literature. It enables its technical users to build their own customised text mining solutions by providing a wide array of interoperable and configurable elementary components that can be seamlessly integrated into processing workflows. With Argo's graphical annotation interface, domain experts can then make use of the workflows' automatically generated output to curate information of interest. With the continuously rising need to understand the aetiology of diseases as well as the demand for their informed diagnosis and personalised treatment, the curation of disease-relevant information from medical and clinical documents has become an indispensable scientific activity. In the Fifth BioCreative Challenge Evaluation Workshop (BioCreative V), there was substantial interest in the mining of literature for disease-relevant information. Apart from a panel discussion focussed on disease annotations, the chemical-disease relations (CDR) track was also organised to foster the sharing and advancement of disease annotation tools and resources. This article presents the application of Argo’s capabilities to the literature-based annotation of diseases. As part of our participation in BioCreative V’s User Interactive Track (IAT), we demonstrated and evaluated Argo’s suitability to the semi-automatic curation of chronic obstructive pulmonary disease (COPD) phenotypes. Furthermore, the workbench facilitated the development of some of the CDR track’s top-performing web services for normalising disease mentions against the Medical Subject Headings (MeSH) database. In this work, we highlight Argo’s support for developing various types of bespoke workflows ranging from ones which enabled us to easily incorporate information from various databases, to those which train and apply machine learning-based concept recognition

  16. Estimating the Velocity and Transport of the East Australian Current using Argo, XBT, and Altimetry

    NASA Astrophysics Data System (ADS)

    Zilberman, N. V.; Roemmich, D. H.; Gille, S. T.

    2016-02-01

    Western Boundary Currents (WBCs) are the strongest ocean currents in the subtropics, and constitute the main pathway through which warm water-masses transit from low to mid-latitudes in the subtropical gyres of the Atlantic, Pacific, and Indian Oceans. Heat advection by WBCs has a significant impact on heat storage in subtropical mode waters formation regions and at high latitudes. The possibility that the magnitude of WBCs might change under greenhouse gas forcing has raised significant concerns. Improving our knowledge of WBC circulation is essential to accurately monitor the oceanic heat budget. Because of the narrowness and strong mesoscale variability of WBCs, estimation of WBC velocity and transport places heavy demands on any potential sampling scheme. One strategy for studying WBCs is to combine complementary data sources. High-resolution bathythermograph (HRX) profiles to 800-m have been collected along transects crossing the East Australian Current (EAC) system at 3-month nominal sampling intervals since 1991. EAC transects, with spatial sampling as fine as 10-15 km, are obtained off Brisbane (27°S) and Sydney (34°S), and crossing the related East Auckland Current north of Auckland. Here, HRX profiles collected since 2004 off Brisbane are merged with Argo float profiles and 1000 m trajectory-based velocities to expand HRX shear estimates to 2000-m and to estimate absolute geostrophic velocity and transport. A method for combining altimetric data with HRX and Argo profiles to mitigate temporal aliasing by the HRX transects and to reduce sampling errors in the HRX/Argo datasets is described. The HRX/Argo/altimetry-based estimate of the time-mean poleward alongshore transport of the EAC off Brisbane is 18.3 Sv, with a width of about 180 km, and of which 3.7 Sv recirculates equatorward on a similar spatial scale farther offshore. Geostrophic transport anomalies in the EAC at 27°S show variability of ± 1.3 Sv at interannual time scale related to ENSO. The

  17. Recent Results from ArgoNeuT and Status of MicroBooNE

    SciTech Connect

    Szelc, Andrzej

    2015-07-10

    Liquid Argon Time Projection Chamber (LArTPC) detectors hold the key to answering the outstanding questions about the role of neutrinos in the Standard Model of Particle physics and beyond. Their fine granularity combined with calorimetric capabilities allows for precision measurements that answering these questions will require. Here, we discuss the recent results from the ArgoNeuT experiment as well as the status and prospects for MicroBooNE, both a part of the US-based LArTPC neutrino program.

  18. Recent results in γ-ray astronomy with the ARGO-YBJ detector

    NASA Astrophysics Data System (ADS)

    Di Girolamo, Tristano

    2017-03-01

    The ARGO-YBJ air shower detector has been in stable data taking for five years at the YangBaJing Cosmic Ray Laboratory (Tibet, P.R. China, 4300m a.s.l.) with a duty cycle > 86% and an energy threshold of a few hundreds of GeV. With the scaler mode technique, the minimum threshold of 1 GeV can be reached. In this paper recent results in γ-ray astronomy will be presented, including those from 4.5 years of observations of the blazar Mrk 421 in common with the Fermi satellite.

  19. On the Assimilation of Argo Float Trajectories into the Mediterranean Forecasting System

    NASA Astrophysics Data System (ADS)

    Nilsson, Jenny A. U.; Dobricic, Srdjan; Taillandier, Vincent; Poulain, Pierre-Marie; Pinardi, Nadia

    2010-05-01

    The Mediterranean Forecasting System (MFS) has been in operations for nearly a decade, and it is continuously providing analyses on a weekly basis for the region. These forecasts are of great importance as they provide local and basin-scale information of the environmental state of the sea, and are also highly useful for tracking oil spill and search-and-rescue missions. The circulation in the interior Mediterranean Sea is to a large extent characterized by meso-scale eddies, which often have proved somewhat difficult to simulate in an adequate manner due to their high temporal and spatial variability. Data assimilation is a widely used method to improve the forecast skill of operational models and, in this study, the three-dimensional variational (OceanVAR) scheme has been extended to include Argo float trajectories, with the objective to constrain and ameliorate the numerical output primarily in terms of the subsurface velocity fields. The method of implementing the float positions into the cost function is highly unique, since it uses a tangent-linear trajectory model as the observational operator. The modeled float trajectories are obtained by integration of the linearized particle advection equation during 5-day periods, corresponding to the time when the Argo floats are drifting at parking depth (350m). For the first time, basin-wide numerical experiments have been undertaken for a 3-year period (2005-2007), and it was concluded that the trajectory assimilation significately improves the simulation of Argo float trajectories based upon analyses. Indeed, statistical studies of the root-mean-square differences between the observed and analysed float positions showed that the new OceanVar scheme yields ~20% better estimates of the predicted ocean currents. It was furthermore established that the extended OceanVAR scheme does not compromise the forecast/analysis quality of the other state variables (e.g. SLAs, temperature, salinity). A notable decrease in

  20. Lozenge directly activates argos and klumpfuss to regulate programmed cell death.

    PubMed

    Wildonger, Jill; Sosinsky, Alona; Honig, Barry; Mann, Richard S

    2005-05-01

    We show that reducing the activity of the Drosophila Runx protein Lozenge (Lz) during pupal development causes a decrease in cell death in the eye. We identified Lz-binding sites in introns of argos (aos) and klumpfuss (klu) and demonstrate that these genes are directly activated targets of Lz. Loss of either aos or klu reduces cell death, suggesting that Lz promotes apoptosis at least in part by regulating aos and klu. These results provide novel insights into the control of programmed cell death (PCD) by Lz during Drosophila eye development.

  1. GrameneMart: the biomart data portal for the gramene project

    USDA-ARS?s Scientific Manuscript database

    The Gramene project was an early adopter of the BioMart software, which remains an integral and well-used component of the Gramene web site. BioMart accessible data sets include plant gene annotations, plant variation catalogues, genetic markers, physical mapping entities, public DNA/mRNA sequences ...

  2. Carmen Martín Gaite and the Writing of History

    ERIC Educational Resources Information Center

    Herzberger, David K.

    2015-01-01

    In this brief article, David Herzberger begins by describing how, with the help of Juan Benet as her interlocutor in 1966, renowned Spanish author Carmen Martín Gaite found her historiographic voice. Herzberger goes on to examine how this relates to Martín Gaite's legacy in historiography and her understanding of the Franco regime and the Spanish…

  3. Sustaining Higher Education Using Wal-Mart's Best Supply Chain Management Practices

    ERIC Educational Resources Information Center

    Comm, Clare L.; Mathaisel, Dennis F. X.

    2008-01-01

    Purpose: The costs in higher education are increasing and need to be controlled. This paper aims to demonstrate what lessons higher education could learn from Wal-Mart's reasons for its financial success with its focus on efficient and effective supply chain management (SCM) best practices. Design/methodology/approach: Wal-Mart's best practices in…

  4. Sustaining Higher Education Using Wal-Mart's Best Supply Chain Management Practices

    ERIC Educational Resources Information Center

    Comm, Clare L.; Mathaisel, Dennis F. X.

    2008-01-01

    Purpose: The costs in higher education are increasing and need to be controlled. This paper aims to demonstrate what lessons higher education could learn from Wal-Mart's reasons for its financial success with its focus on efficient and effective supply chain management (SCM) best practices. Design/methodology/approach: Wal-Mart's best practices in…

  5. The use of radio telemetry in Martes research: techniques and technologies

    Treesearch

    Craig M. Thompson; Rebecca A. Green; Joel Sauder; Kathryn L. Purcell; Richard Sweitzer; Jon. Armeno

    2012-01-01

    Radiotelemetry was fi rst used on a Martes species in 1972, when 5 American martens ( Martes americana ) captured incidentally during a snowshoe hare ( Lepus americanus ) research project in Minnesota were radio-collared. Since then, at least 128 research projects have used radiotelemetry to investigate...

  6. Concepto de ingeniería del Laboratorio Científico de Marte

    NASA Image and Video Library

    El robot más grande y "más malo", y más nuevo para Marte es el Laboratorio Científico de Marte. Tiene el tamaño de un vehículo utilitario deportivo y está provisto de 10 instrumentos, nunca antes h...

  7. A Technique for Merging Areas in Timber Mart-South Data

    Treesearch

    Jeffrey P. Prestemon; John M. Pye

    2000-01-01

    For over 20 yr, TimberMart-South (TMS) has been distributing prices of various wood products from southern forests. In the beginning of 1988, the reporting frequency changed from monthly to quarterly, a change readily addressed through a variety established statistical techniques. A more significant statistical challenge is Timber Mart-South's change in 1992 from...

  8. La Ciencia y el Laboratorio Científico de Marte

    NASA Image and Video Library

    el robot más nuevo fabricado para Marte es el Laboratorio Científico de Marte o Curiosity. ¡Se encuentra listo para deambular por el planeta rojo con el mayor y más avanzado conjunto de instrumento...

  9. Carmen Martín Gaite and the Writing of History

    ERIC Educational Resources Information Center

    Herzberger, David K.

    2015-01-01

    In this brief article, David Herzberger begins by describing how, with the help of Juan Benet as her interlocutor in 1966, renowned Spanish author Carmen Martín Gaite found her historiographic voice. Herzberger goes on to examine how this relates to Martín Gaite's legacy in historiography and her understanding of the Franco regime and the Spanish…

  10. Argo data assimilation and its effect on climate state estimation and forecasting in the western North Pacific using a coupled model

    NASA Astrophysics Data System (ADS)

    Nishikawa, Shiro; Ishikawa, Yoichi; Masuda, Shuhei; Hiyoshi, Yoshihisa; Sasaki, Yuji; Igarashi, Hiromichi

    2015-04-01

    In this study, we investigated the effects of ocean subsurface data (Argo data) on climate state estimation and forecasting, focusing on the reproduction of North Pacific subtropical mode water (STMW) using a four-dimensional variational data assimilation system with a coupled model. We produced two reanalysis plus forecast data sets for the ocean and atmosphere in 2010 using a 3 month assimilation period: the first including Argo data (Argo case) and the second did not include Argo data (control case). In the control case, the Kuroshio, Kuroshio Extension front, and recirculation gyres along the front were not adequately reproduced. Consequently, there were large biases in temperature and salinity in the western North Pacific. The assimilation of Argo data effectively corrected these biases and significantly improved reproduction of the Kuroshio fronts and recirculation gyres, resulting in a more realistic reproduction of the winter mixed layer and STMW. The correction of these biases is critical to the 1-3 year predictions of the STMW core properties, and the assimilation of Argo data enables prediction of these properties for more than a year. We showed that assimilation of Argo data affects the surface atmospheric temperature above the STMW formation region.

  11. The ARGOS wavefront sensor pnCCD camera for an ELT: characteristics, limitations and applications

    NASA Astrophysics Data System (ADS)

    Orban de Xivry, G.; Ihle, S.; Ziegleder, J.; Barl, L.; Hartmann, R.; Rabien, S.; Soltau, H.; Strueder, L.

    2011-09-01

    From low-order to high-order AO, future wave front sensors on ELTs require large, fast, and low-noise detectors with high quantum efficiency and low dark current. While a detector for a high-order Shack-Hartmann WFS does not exist yet, the current CCD technology pushed to its limits already provides several solutions for the ELT AO detector requirements. One of these devices is the new WFS pnCCD camera of ARGOS, the Ground-Layer Adaptive Optics system (GLAO) for LUCIFER at LBT. Indeed, with its 264x264 pixels, 48 mu m pixel size and 1kHz frame rate, this camera provides a technological solution to different needs of the AO systems for ELTs, such as low-order but as well possibly higher order correction using pyramid wavefront sensing. In this contribution, we present the newly developped WFS pnCCD camera of ARGOS and how it fulfills future detector needs of AO on ELTs.

  12. Testing and integrating the laser system of ARGOS: the ground layer adaptive optics for LBT

    NASA Astrophysics Data System (ADS)

    Loose, C.; Rabien, S.; Barl, L.; Borelli, J.; Deysenroth, M.; Gaessler, W.; Gemperlein, H.; Honsberg, M.; Kulas, M.; Lederer, R.; Raab, W.; Rahmer, G.; Ziegleder, J.

    2012-07-01

    The Laser Guide Star facility ARGOS will provide Ground Layer Adaptive Optics to the Large Binocular Telescope (LBT). The system operates three pulsed laser beacons above each of the two primary mirrors, which are Rayleigh scattered in 12km height. This enables correction over a wide field of view, using the adaptive secondary mirror of the LBT. The ARGOS laser system is designed around commercially available, pulsed Nd:YAG lasers working at 532 nm. In preparation for a successful commissioning, it is important to ascertain that the specifications are met for every component of the laser system. The testing of assembled, optical subsystems is likewise necessary. In particular it is required to confirm a high output power, beam quality and pulse stability of the beacons. In a second step, the integrated laser system along with its electronic cabinets are installed on a telescope simulator. This unit is capable of carrying the whole assembly and can be tilted to imitate working conditions at the LBT. It allows alignment and functionality testing of the entire system, ensuring that flexure compensation and system diagnosis work properly in different orientations.

  13. Comparisons between data assimilated HYCOM output and in situ Argo measurements in the Bay of Bengal

    NASA Astrophysics Data System (ADS)

    Wilson, E. A.; Riser, S.

    2014-12-01

    This study evaluates the performance of data assimilated Hybrid Coordinate Ocean Model (HYCOM) output for the Bay of Bengal from September 2008 through July 2013. We find that while HYCOM assimilates Argo data, the model still suffers from significant temperature and salinity biases in this region. These biases are most severe in the northern Bay of Bengal, where the model tends to be too saline near the surface and too fresh at depth. The maximum magnitude of these biases is approximately 0.6 PSS. We also find that the model's salinity biases have a distinct seasonal cycle. The most problematic periods are the months following the summer monsoon (Oct-Jan). HYCOM's near surface temperature estimates compare more favorably with Argo, but significant errors exist at deeper levels. We argue that optimal interpolation will tend to induce positive salinity biases in the northern regions of the Bay. Further, we speculate that these biases are introduced when the model relaxes to climatology and assimilates real-time data.

  14. Integration and laboratory characterization of the ARGOS laser guide star wavefront sensors

    NASA Astrophysics Data System (ADS)

    Busoni, Lorenzo; Bonaglia, Marco; Carbonaro, Luca; Mazzoni, Tommaso; Antichi, Jacopo; Esposito, Simone; Orban De Xivry, Gilles; Rabien, Sebastian

    2013-12-01

    The integration status of the ARGOS wavefront sensors is presented. ARGOS is the laser guide star AO program for the LBT. It will implement a Ground Layer AO correction for the instruments LUCI, an infrared imaging and spectrograph camera, using 3 pulsed low-altitudes Rayleigh beacons for each LBT's eye. It profits of the LBT's adaptive secondary mirrors and of FLAO's pyramid unit for NGS sensing. Each LGS is independently stabilized for on-sky jitter and range-gated using custom Pockels cells and then sensed by a 15x15 SH sensor. The 3 pupil images are reimaged on a single lenslet array and a single detector. In the WFS are also installed 3 patrol cameras for the acquisition of the laser beacons, a system for the stabilization of the pupil images on the lenslet array and an internal source for calibration purposes. The two units are now completing the integration phase in Arcetri premises. We describe the characterization of the units and the closed-loop test realized using a deformable MEMS mirror.

  15. On the assessment of Argo float trajectory assimilation in the Mediterranean Forecasting System

    NASA Astrophysics Data System (ADS)

    Nilsson, Jenny A. U.; Dobricic, Srdjan; Pinardi, Nadia; Taillandier, Vincent; Poulain, Pierre-Marie

    2011-10-01

    The Mediterranean Forecasting System (MFS) has been operational for a decade, and is continuously providing forecasts and analyses for the region. These forecasts comprise local- and basin-scale information of the environmental state of the sea and can be useful for tracking oil spills and supporting search-and-rescue missions. Data assimilation is a widely used method to improve the forecast skill of operational models and, in this study, the three-dimensional variational (OceanVar) scheme has been extended to include Argo float trajectories, with the objective of constraining and ameliorating the numerical output primarily in terms of the intermediate velocity fields at 350 m depth. When adding new datasets, it is furthermore crucial to ensure that the extended OceanVar scheme does not decrease the performance of the assimilation of other observations, e.g., sea-level anomalies, temperature, and salinity. Numerical experiments were undertaken for a 3-year period (2005-2007), and it was concluded that the Argo float trajectory assimilation improves the quality of the forecasted trajectories with ~15%, thus, increasing the realism of the model. Furthermore, the MFS proved to maintain the forecast quality of the sea-surface height and mass fields after the extended assimilation scheme had been introduced. A comparison between the modeled velocity fields and independent surface drifter observations suggested that assimilating trajectories at intermediate depth could yield improved forecasts of the upper ocean currents.

  16. The ARGOS wavefront sensor pnCCD camera for an ELT: characteristics, limitations and applications

    NASA Astrophysics Data System (ADS)

    de Xivry, G. Orban; Ihle, S.; Ziegleder, J.; Barl, L.; Hartmann, R.; Rabien, S.; Soltau, H.; Strueder, L.

    2011-09-01

    From low-order to high-order AO, future wave front sensors on ELTs require large, fast, and low-noise detectors with high quantum efficiency and low dark current. While a detector for a high-order Shack-Hartmann WFS does not exist yet, the current CCD technology pushed to its limits already provides several solutions for the ELT AO detector requirements. One of these devices is the new WFS pnCCD camera of ARGOS, the Ground-Layer Adaptive Optics system (GLAO) for LUCIFER at LBT. Indeed, with its 264x264 pixels, 48 mu m pixel size and 1kHz frame rate, this camera provides a technological solution to different needs of the AO systems for ELTs, such as low-order but as well possibly higher order correction using pyramid wavefront sensing. In this contribution, we present the newly developped WFS pnCCD camera of ARGOS and how it fulfills future detector needs of AO on ELTs.

  17. Pre-shipment test of the ARGOS laser guide star wavefront sensor

    NASA Astrophysics Data System (ADS)

    Bonaglia, Marco; Busoni, Lorenzo; Mazzoni, Tommaso; Puglisi, Alfio; Antichi, Jacopo; Esposito, Simone; Orban de Xivry, Gilles; Rabien, Sebastian

    2014-08-01

    We present the results of the laboratory characterization of the ARGOS LGS wavefront sensor (LGSW) and dichroic units. ARGOS is the laser guide star adaptive optics system of the Large Binocular Telescope (LBT). It implements a Ground Layer Adaptive Optics (GLAO) correction for LUCI, an infrared imager and multi-object spectrograph (MOS), using 3 pulsed Rayleigh beacons focused at 12km altitude. The LGSW is a Shack-Hartman sensor having 15 × 15 subaspertures over the telescope pupil. Each LGS is independently stabilized for on-sky jitter and gated to reduce spot elongation. The 3 LGS pupils are stabilized to compensate mechanical flexure and are arranged on a single detector. Two units of LGSW have been produced and tested at Arcetri Observatory. We report on the results obtained in the pre-shipment laboratory test: internal active flexure compensation loop performance, optomechanical stability under different gravity conditions, thermal cycling, Pockels cells performance. We also update on the upcoming installation and commissioning campaign at LBT.

  18. The Arabidopsis ARGOS-LIKE gene regulates cell expansion during organ growth.

    PubMed

    Hu, Yuxin; Poh, Huay Mei; Chua, Nam-Hai

    2006-07-01

    Cell expansion, and its coordination with cell division, plays a critical role in the growth and development of plant organs. However, the genes controlling cell expansion during organogenesis are largely unknown. Here, we demonstrate that a novel Arabidopsis gene, ARGOS-LIKE (ARL), which has some sequence homology to the ARGOS gene, is involved in this process. Reduced expression or overexpression of ARL in Arabidopsis results in smaller or larger cotyledons and leaves as well as other lateral organs, respectively. Anatomical examination of cotyledons and leaves in ARL transgenic plants demonstrates that the alteration in size can be attributed to changes in cell size rather than cell number, indicating that ARL plays a role in cell expansion-dependent organ growth. ARL is upregulated by brassinosteroid (BR) and this induction is impaired in the BR-insensitive mutant bri1, but not in the BR-deficient mutant det2. Ectopic expression of ARL in bri1-119 partially restores cell growth in cotyledons and leaves. Our results suggest that ARL acts downstream of BRI1 and partially mediates BR-related cell expansion signals during organ growth.

  19. Ocean response to typhoons in the western North Pacific: Composite results from Argo data

    NASA Astrophysics Data System (ADS)

    Lin, Sheng; Zhang, Wen-Zhou; Shang, Shao-Ping; Hong, Hua-Sheng

    2017-05-01

    Composite structures of ocean temperature and salinity anomalies caused by tropical cyclones (TCs) or typhoons in the western North Pacific Ocean were obtained from Argo data. These structures were used to analyze ocean responses to typhoons and the dynamic mechanisms inherent in those responses with a particular focus on upwelling. TC-induced cooling is often strongly rightward-biased in the surface layer, and shifts toward the typhoon track at depths exceeding roughly 100 m. In the central water column within approximately 75 km of the typhoon track, subsurface warming predicted by vertical mixing is restrained and replaced by cooling due to upwelling. Upwelling contributes 15% on average to temperature cooling in the near surface layer (10-30 m), 84% in the subsurface layer (30-250 m) and 94% in the deep layer (250-600 m) during the period of 0.5-2.5 days after the typhoon's passage. It is suggested that the sea surface cooling effect of vertical mixing can be enhanced by the upwelling. The effect of upwelling is also prominent in the salinity response to typhoons. The composite results from the Argo data clearly reveal basic ocean responses to typhoons and indicate the important role of upwelling therein.

  20. From satellite altimetry to operational oceanography and Argo: three revolutions in oceanography (Fridtjof Nansen Medal Lecture)

    NASA Astrophysics Data System (ADS)

    Le Traon, P. Y.

    2012-04-01

    The launch of the US/French mission Topex/Poseidon (T/P) (CNES/NASA) in August 1992 was the start of a revolution in oceanography. For the first time, a very precise altimeter system optimized for large scale sea level and ocean circulation observations was flying. Topex/Poseidon revolutionized our vision and understanding of the ocean. It provided new views of the large scale seasonal and interannual sea level and ocean circulation variations. T/P alone could not observe the mesoscale circulation. In the 1990s, the ESA satellites ERS-1/2 were flying simultaneously with T/P. The ERS-1/2 orbit was well adapted for mesoscale circulation sampling but the orbit determination and altimeter performance were much less precise than for T/P. We demonstrated that we could use T/P as a reference mission for ERS-1/2 and bring the ERS-1/2 data to an accuracy level comparable to T/P. This was an essential first step for the merging of T/P and ERS-1/2. The second step required the development of a global optimal interpolation method. Near real time high resolution global sea level anomaly maps were then derived. These maps have been operationally produced as part of the SSALTO/DUACS system for the last 15 years. They are now widely used by the oceanographic community and have contributed to a much better understanding and recognition of the role and importance of mesoscale dynamics. The unique capability of satellite altimetry to observe the global ocean in near real time at high resolution was essential to the development of global ocean forecasting, a second revolution in oceanography. The Global Ocean Data Assimilation Experiment (GODAE) (1998-2008) was phased with the T/P and ERS-1/2 successors (Jason-1 and ENVISAT) and was instrumental in the development of global operational oceanography capabilities. Europe played a leading role in GODAE. In 1998, the global in-situ observing system was inadequate for the global scope of GODAE. This led to the development of Argo, an

  1. The pre-Argo ocean reanalyses may be seriously affected by the spatial coverage of moored buoys

    PubMed Central

    Sivareddy, S.; Paul, Arya; Sluka, Travis; Ravichandran, M.; Kalnay, Eugenia

    2017-01-01

    Assimilation methods, meant to constrain divergence of model trajectory from reality using observations, do not exactly satisfy the physical laws governing the model state variables. This allows mismatches in the analysis in the vicinity of observation locations where the effect of assimilation is most prominent. These mismatches are usually mitigated either by the model dynamics in between the analysis cycles and/or by assimilation at the next analysis cycle. However, if the observations coverage is limited in space, as it was in the ocean before the Argo era, these mechanisms may be insufficient to dampen the mismatches, which we call shocks, and they may remain and grow. Here we show through controlled experiments, using real and simulated observations in two different ocean models and assimilation systems, that such shocks are generated in the ocean at the lateral boundaries of the moored buoy network. They thrive and propagate westward as Rossby waves along these boundaries. However, these shocks are essentially eliminated by the assimilation of near-homogenous global Argo distribution. These findings question the fidelity of ocean reanalysis products in the pre-Argo era. For example, a reanalysis that ignores Argo floats and assimilates only moored buoys, wrongly represents 2008 as a negative Indian Ocean Dipole year. PMID:28429748

  2. Behavior of Dermochelys coriacea in captivity (animal carrying dummy PTT in preliminary phase of an ARGOS experiment)

    NASA Astrophysics Data System (ADS)

    Duron-Dufrenne, M.

    The degree to which a turtle would accept the Transat-type ARGOS PTT, and the reliability of the harness securing it to the carapace were tested, using an adult kept in a swimming pool for 36 hr. Its pelagic behavior turns out to be comparable to that in the open sea, the animal appearing unperturbed by the equipment.

  3. The pre-Argo ocean reanalyses may be seriously affected by the spatial coverage of moored buoys

    NASA Astrophysics Data System (ADS)

    Sivareddy, S.; Paul, Arya; Sluka, Travis; Ravichandran, M.; Kalnay, Eugenia

    2017-04-01

    Assimilation methods, meant to constrain divergence of model trajectory from reality using observations, do not exactly satisfy the physical laws governing the model state variables. This allows mismatches in the analysis in the vicinity of observation locations where the effect of assimilation is most prominent. These mismatches are usually mitigated either by the model dynamics in between the analysis cycles and/or by assimilation at the next analysis cycle. However, if the observations coverage is limited in space, as it was in the ocean before the Argo era, these mechanisms may be insufficient to dampen the mismatches, which we call shocks, and they may remain and grow. Here we show through controlled experiments, using real and simulated observations in two different ocean models and assimilation systems, that such shocks are generated in the ocean at the lateral boundaries of the moored buoy network. They thrive and propagate westward as Rossby waves along these boundaries. However, these shocks are essentially eliminated by the assimilation of near-homogenous global Argo distribution. These findings question the fidelity of ocean reanalysis products in the pre-Argo era. For example, a reanalysis that ignores Argo floats and assimilates only moored buoys, wrongly represents 2008 as a negative Indian Ocean Dipole year.

  4. Circulation analysis in the northwest Indian Ocean using ARGO floats and surface drifter observations, and SODA reanalysis output

    NASA Astrophysics Data System (ADS)

    Vitale, Sarah Stryker; DiMarco, Steven F.; Seidel, Howard F.; Wang, Zhankun

    2017-06-01

    This study incorporates observations from Array of Real-time Geostrophic Oceanography (ARGO) floats and surface drifters to identify seasonal circulation patterns at the surface, 1000 m, 1500 m, and 2000 m in the northwest Indian Ocean, and quantify velocities associated with them. A skill comparison of the Simple Ocean Data Assimilation (SODA) reanalysis output was also performed to contribute to the understanding of the circulation dynamics in this region. Subsurface currents were quantified and validated using the ARGO float data. Surface currents were identified using surface drifter data and compared to the subsurface observations to enhance our previous understanding of surface circulations. Quantified Southwest Monsoon surface currents include the Somali Current (vmax = 179.5 cm/s), the East Arabian Current (vmax = 52.3 cm/s), and the Southwest Monsoon Current (vmax = 51.2 cm/s). Northeastward flow along the Somali coast is also observed at 1000 m (vmax = 26.1 cm/s) and 1500 m (vmax = 12.7 cm/s). Currents associated with the Great Whirl are observed at the surface (vmax = 161.4 cm/s) and at 1000 m (vmax = 16.2 cm/s). In contrast to previous studies, both ARGO and surface drifter data show the Great Whirl can form as early as the boreal Spring intermonsoon, lasting until the boreal Fall intermonsoon. The Arabian Sea exhibits eastward/southeastward flow at the surface, 1000 m, 1500 m, and 2000 m. Quantified Northeast Monsoon surface currents include the Somali Current (vmax = 97.3 cm/s), Northeast Monsoon Current (vmax = 30.0 cm/s), and the North Equatorial Current (vmax = 28.5 cm/s). Southwestward flow along the Somali coast extends as deep as 1500 m. Point-by-point vector and scalar correlations of SODA output to ARGO and surface drifter data showed that surface SODA output and surface drifter data generally produced a strong correlation attributed to surface currents strongly controlled by the monsoons, while subsurface correlations of SODA output and ARGO

  5. A Southern Ocean variability study using the Argo-based Model for Investigation of the Global Ocean (AMIGO)

    NASA Astrophysics Data System (ADS)

    Lebedev, Konstantin

    2017-04-01

    The era of satellite observations of the ocean surface that started at the end of the 20th century and the development of the Argo project in the first years of the 21st century, designed to collect information of the upper 2000 m of the ocean using satellites, provides unique opportunities for continuous monitoring of the Global Ocean state. Starting from 2005, measurements with the Argo floats have been performed over the majority of the World Ocean. In November 2007, the Argo program reached coverage of 3000 simultaneously operating floats (one float in a three-degree square) planned during the development of the program. Currently, 4000 Argo floats autonomously profile the upper 2000-m water column of the ocean from Antarctica to Spitsbergen increasing World Ocean temperature and salinity databases by 12000 profiles per month. This makes it possible to solve problems on reconstructing and monitoring the ocean state on an almost real-time basis, study the ocean dynamics, obtain reasonable estimates of the climatic state of the ocean in the last decade and estimate existing intraclimatic trends. We present the newly developed Argo-Based Model for Investigation of the Global Ocean (AMIGO), which consists of a block for variational interpolation of the profiles of drifting Argo floats to a regular grid and a block for model hydrodynamic adjustment of variationally interpolated fields. Such a method makes it possible to obtain a full set of oceanographic characteristics - temperature, salinity, density, and current velocity - using irregularly located Argo measurements (the principle of the variational interpolation technique entails minimization of the misfit between the interpolated fields defined on the regular grid and irregularly distributed data; hence the optimal solution passes as close to the data as possible). The simulations were performed for the entire globe limited in the north by 85.5° N using 1° grid spacing in both longitude and latitude. At the

  6. The Topology of the l-Arginine Exporter ArgO Conforms to an Nin-Cout Configuration in Escherichia coli: Requirement for the Cytoplasmic N-Terminal Domain, Functional Helical Interactions, and an Aspartate Pair for ArgO Function.

    PubMed

    Pathania, Amit; Gupta, Arvind Kumar; Dubey, Swati; Gopal, Balasubramanian; Sardesai, Abhijit A

    2016-12-01

    ArgO and LysE are members of the LysE family of exporter proteins and ordinarily mediate the export of l-arginine (Arg) in Escherichia coli and l-lysine (Lys) and Arg in Corynebacterium glutamicum, respectively. Under certain conditions, ArgO also mediates Lys export. To delineate the arrangement of ArgO in the cytoplasmic membrane of E. coli, we have employed a combination of cysteine accessibility in situ, alkaline phosphatase fusion reporters, and protein modeling to arrive at a topological model of ArgO. Our studies indicate that ArgO assumes an Nin-Cout configuration, potentially forming a five-transmembrane helix bundle flanked by a cytoplasmic N-terminal domain (NTD) comprising roughly its first 38 to 43 amino acyl residues and a short periplasmic C-terminal region (CTR). Mutagenesis studies indicate that the CTR, but not the NTD, is dispensable for ArgO function in vivo and that a pair of conserved aspartate residues, located near the opposing edges of the cytoplasmic membrane, may play a pivotal role in facilitating transmembrane Arg flux. Additional studies on amino acid substitutions that impair ArgO function in vivo and their derivatives bearing compensatory amino acid alterations indicate a role for intramolecular interactions in the Arg export mechanism, and some interactions are corroborated by normal-mode analyses. Lastly, our studies suggest that ArgO may exist as a monomer in vivo, thus highlighting the requirement for intramolecular interactions in ArgO, as opposed to interactions across multiple ArgO monomers, in the formation of an Arg-translocating conduit.

  7. [The myth of the Gaucho Martín Fierro].

    PubMed

    Yampey, N

    1985-06-01

    The Gaucho Martín Fierro, written by José Hernández in 1872 and 1879, is today considered the most beautiful of the original productions of the River Plate literature. It is the one that best represents the mentality and the individual and social attitudes and customs of the common people. Hernández re-creates not only their rustic speech, but also the natural prosody peculiar to the peasant. Most especially, he gives vivid and pathetic shape to the myth of the gaucho in his context: the rural community in its early stages. This paper analyzes the epic nature of the poem (its glamour of adventure, courage and destiny), its nature as a national epic (depecting the values and aspirations of a developing society) and especially its character as a mythical prototype (referring to origins, to destiny and to a "primitive crime"). This myth is embodied by a stoic and conflictive figure, product of an ethnic mixture, but more essentially of transculturation. The conflict and dissociations are revealed as much by the two contrasting parts of the poem as by the vicissitudes of Hernández' own life. The psychological, historical, social and political effects of the poem are analyzed. Argentines have identified themselves on several planes with this mythical hero, since Martín Fierro represents the drama of dissociation, trikery, and unsuccessful attempts at social integration or compromise throughout Argentina's dramatic history.

  8. From satellite altimetry to Argo and operational oceanography: three revolutions in oceanography

    NASA Astrophysics Data System (ADS)

    Le Traon, P. Y.

    2013-07-01

    The launch of the US/French mission Topex/Poseidon (T/P) (CNES/NASA) in August 1992 was the start of a revolution in oceanography. For the first time, a very precise altimeter system optimized for large scale sea level and ocean circulation observations was flying. T/P alone could not observe the mesoscale circulation. In the 1990s, the ESA satellites ERS-1/2 were flying simultaneously with T/P. Together with my CLS colleagues, we demonstrated that we could use T/P as a reference mission for ERS-1/2 and bring the ERS-1/2 data to an accuracy level comparable to T/P. Near real time high resolution global sea level anomaly maps were then derived. These maps have been operationally produced as part of the SSALTO/DUACS system for the last 15 yr. They are now widely used by the oceanographic community and have contributed to a much better understanding and recognition of the role and importance of mesoscale dynamics. Altimetry needs to be complemented with global in situ observations. In the end of the 90s, a major international initiative was launched to develop Argo, the global array of profiling floats. This has been an outstanding success. Argo floats now provide the most important in situ observations to monitor and understand the role of the ocean on the earth climate and for operational oceanography. This is a second revolution in oceanography. The unique capability of satellite altimetry to observe the global ocean in near real time at high resolution and the development of Argo were essential to the development of global operational oceanography, the third revolution in oceanography. The Global Ocean Data Assimilation Experiment (GODAE) was instrumental in the development of the required capabilities. This paper provides an historical perspective on the development of these three revolutions in oceanography which are very much interlinked. This is not an exhaustive review and I will mainly focus on the contributions we made together with many colleagues and

  9. From satellite altimetry to Argo and operational oceanography: three revolutions in oceanography

    NASA Astrophysics Data System (ADS)

    Le Traon, P. Y.

    2013-10-01

    The launch of the French/US mission Topex/Poseidon (T/P) (CNES/NASA) in August 1992 was the start of a revolution in oceanography. For the first time, a very precise altimeter system optimized for large-scale sea level and ocean circulation observations was flying. T/P alone could not observe the mesoscale circulation. In the 1990s, the ESA satellites ERS-1/2 were flying simultaneously with T/P. Together with my CLS colleagues, we demonstrated that we could use T/P as a reference mission for ERS-1/2 and bring the ERS-1/2 data to an accuracy level comparable to T/P. Near-real-time high-resolution global sea level anomaly maps were then derived. These maps have been operationally produced as part of the SSALTO/DUACS system for the last 15 yr. They are now widely used by the oceanographic community and have contributed to a much better understanding and recognition of the role and importance of mesoscale dynamics. Altimetry needs to be complemented with global in situ observations. At the end of the 90s, a major international initiative was launched to develop Argo, the global array of profiling floats. This has been an outstanding success. Argo floats now provide the most important in situ observations to monitor and understand the role of the ocean on the earth climate and for operational oceanography. This is a second revolution in oceanography. The unique capability of satellite altimetry to observe the global ocean in near-real-time at high resolution and the development of Argo were essential for the development of global operational oceanography, the third revolution in oceanography. The Global Ocean Data Assimilation Experiment (GODAE) was instrumental in the development of the required capabilities. This paper provides an historical perspective on the development of these three revolutions in oceanography which are very much interlinked. This is not an exhaustive review and I will mainly focus on the contributions we made together with many colleagues and

  10. The Vitamin D Analog, MART-10, Attenuates Triple Negative Breast Cancer Cells Metastatic Potential.

    PubMed

    Chiang, Kun-Chun; Yeh, Ta-Sen; Chen, Shin-Cheh; Pang, Jong-Hwei S; Yeh, Chun-Nan; Hsu, Jun-Te; Chen, Li-Wei; Kuo, Sheng-Fong; Takano, Masashi; Kittaka, Atsushi; Chen, Tai C; Sun, Chi-Chin; Juang, Horng-Heng

    2016-04-21

    Regarding breast cancer treatment, triple negative breast cancer (TNBC) is a difficult issue. Most TNBC patients die of cancer metastasis. Thus, to develop a new regimen to attenuate TNBC metastatic potential is urgently needed. MART-10 (19-nor-2α-(3-hydroxypropyl)-1α,25(OH)₂D₃), the newly-synthesized 1α,25(OH)₂D₃ analog, has been shown to be much more potent in cancer growth inhibition than 1α,25(OH)₂D₃ and be active in vivo without inducing obvious side effect. In this study, we demonstrated that both 1α,25(OH)₂D₃ and MART-10 could effectively repress TNBC cells migration and invasion with MART-10 more effective. MART-10 and 1α,25(OH)₂D₃ induced cadherin switching (upregulation of E-cadherin and downregulation of N-cadherin) and downregulated P-cadherin expression in MDA-MB-231 cells. The EMT(epithelial mesenchymal transition) process in MDA-MB-231 cells was repressed by MART-10 through inhibiting Zeb1, Zeb2, Slug, and Twist expression. LCN2, one kind of breast cancer metastasis stimulator, was also found for the first time to be repressed by 1α,25(OH)₂D₃ and MART-10 in breast cancer cells. Matrix metalloproteinase-9 (MMP-9) activity was also downregulated by MART-10. Furthermore, F-actin synthesis in MDA-MB-231 cells was attenuated as exposure to 1α,25(OH)₂D₃ and MART-10. Based on our result, we conclude that MART-10 could effectively inhibit TNBC cells metastatic potential and deserves further investigation as a new regimen to treat TNBC.

  11. Adenovirus MART-1–engineered Autologous Dendritic Cell Vaccine for Metastatic Melanoma

    PubMed Central

    Butterfield, Lisa H.; Comin-Anduix, Begonya; Vujanovic, Lazar; Lee, Yohan; Dissette, Vivian B.; Yang, Jin-Quan; Vu, Hong T.; Seja, Elizabeth; Oseguera, Denise K.; Potter, Douglas M.; Glaspy, John A.; Economou, James S.; Ribas, Antoni

    2013-01-01

    Summary We performed a phase 1/2 trial testing the safety, toxicity, and immune response of a vaccine consisting of autologous dendritic cells (DCs) transduced with a replication-defective adenovirus (AdV) encoding the full-length melanoma antigen MART-1/Melan-A (MART-1). This vaccine was designed to activate MART-1–specific CD8+ and CD4+ T cells. Metastatic melanoma patients received 3 injections of 106 or 107 DCs, delivered intradermally. Cell surface phenotype and cytokine production of the DCs used for the vaccines were tested, and indicated intermediate maturity. CD8+ T-cell responses to MART-127-35 were assessed by both major histocompatibility complex class I tetramer and interferon (IFN)-γ enzyme-linked immunosorbent spot (ELISPOT) before, during, and after each vaccine and CD4+ T-cell responses to MART-151-73 were followed by IFN-γ ELISPOT. We also measured antigen response breadth. Determinant spreading from the immunizing antigen MART-1 to other melanoma antigens [gp100, tyrosinase, human melanoma antigen-A3 (MAGE-A3)] was assessed by IFN-γ ELISPOT. Twenty-three patients were enrolled and 14 patients received all 3 scheduled DC vaccines. Significant CD8+ and/or CD4+ MART-1–specific T-cell responses were observed in 6/11 and 2/4 patients evaluated, respectively, indicating that the E1-deleted adeno-virus encoding the cDNA for MART-1/Melan-A (AdV-MART1)/DC vaccine activated both helper and killer T cells in vivo. Responses in CD8+ and CD4+ T cells to additional antigens were noted in 2 patients. The AdVMART1-transduced DC vaccine was safe and immunogenic in patients with metastatic melanoma. PMID:18317358

  12. The Vitamin D Analog, MART-10, Attenuates Triple Negative Breast Cancer Cells Metastatic Potential

    PubMed Central

    Chiang, Kun-Chun; Yeh, Ta-Sen; Chen, Shin-Cheh; Pang, Jong-Hwei S.; Yeh, Chun-Nan; Hsu, Jun-Te; Chen, Li-Wei; Kuo, Sheng-Fong; Takano, Masashi; Kittaka, Atsushi; Chen, Tai C.; Sun, Chi-Chin; Juang, Horng-Heng

    2016-01-01

    Regarding breast cancer treatment, triple negative breast cancer (TNBC) is a difficult issue. Most TNBC patients die of cancer metastasis. Thus, to develop a new regimen to attenuate TNBC metastatic potential is urgently needed. MART-10 (19-nor-2α-(3-hydroxypropyl)-1α,25(OH)2D3), the newly-synthesized 1α,25(OH)2D3 analog, has been shown to be much more potent in cancer growth inhibition than 1α,25(OH)2D3 and be active in vivo without inducing obvious side effect. In this study, we demonstrated that both 1α,25(OH)2D3 and MART-10 could effectively repress TNBC cells migration and invasion with MART-10 more effective. MART-10 and 1α,25(OH)2D3 induced cadherin switching (upregulation of E-cadherin and downregulation of N-cadherin) and downregulated P-cadherin expression in MDA-MB-231 cells. The EMT(epithelial mesenchymal transition) process in MDA-MB-231 cells was repressed by MART-10 through inhibiting Zeb1, Zeb2, Slug, and Twist expression. LCN2, one kind of breast cancer metastasis stimulator, was also found for the first time to be repressed by 1α,25(OH)2D3 and MART-10 in breast cancer cells. Matrix metalloproteinase-9 (MMP-9) activity was also downregulated by MART-10. Furthermore, F-actin synthesis in MDA-MB-231 cells was attenuated as exposure to 1α,25(OH)2D3 and MART-10. Based on our result, we conclude that MART-10 could effectively inhibit TNBC cells metastatic potential and deserves further investigation as a new regimen to treat TNBC. PMID:27110769

  13. A neural network-based method for merging ocean color and Argo data to extend surface bio-optical properties to depth: Retrieval of the particulate backscattering coefficient

    NASA Astrophysics Data System (ADS)

    Sauzède, R.; Claustre, H.; Uitz, J.; Jamet, C.; Dall'Olmo, G.; D'Ortenzio, F.; Gentili, B.; Poteau, A.; Schmechtig, C.

    2016-04-01

    The present study proposes a novel method that merges satellite ocean color bio-optical products with Argo temperature-salinity profiles to infer the vertical distribution of the particulate backscattering coefficient (bbp). This neural network-based method (SOCA-BBP for Satellite Ocean-Color merged with Argo data to infer the vertical distribution of the Particulate Backscattering coefficient) uses three main input components: (1) satellite-based surface estimates of bbp and chlorophyll a concentration matched up in space and time with (2) depth-resolved physical properties derived from temperature-salinity profiles measured by Argo profiling floats and (3) the day of the year of the considered satellite-Argo matchup. The neural network is trained and validated using a database including 4725 simultaneous profiles of temperature-salinity and bio-optical properties collected by Bio-Argo floats, with concomitant satellite-derived products. The Bio-Argo profiles are representative of the global open-ocean in terms of oceanographic conditions, making the proposed method applicable to most open-ocean environments. SOCA-BBP is validated using 20% of the entire database (global error of 21%). We present additional validation results based on two other independent data sets acquired (1) by four Bio-Argo floats deployed in major oceanic basins, not represented in the database used to train the method; and (2) during an AMT (Atlantic Meridional Transect) field cruise in 2009. These validation tests based on two fully independent data sets indicate the robustness of the predicted vertical distribution of bbp. To illustrate the potential of the method, we merged monthly climatological Argo profiles with ocean color products to produce a depth-resolved climatology of bbp for the global ocean.

  14. Local Station: the data read-out basic unit for the ARGO-YBJ experiment

    NASA Astrophysics Data System (ADS)

    Assiro, R.; Aloisio, A.; Catalanotti, S.; Cavaliere, S.; Cesaroni, F.; Creti, P.; Marsella, G.; Mastroianni, S.; Panareo, M.; Pinto, C.; Surdo, A.; ARGO-YBJ Collaboration

    2004-02-01

    ARGO-YBJ is a full coverage layer of Resistive Plate Counters (RPCs) covering an area of about 5.800 m2 to be installed at the YangBaJing Laboratory (Tibet, China) at 4.300 m a.s.l . The DAQ system is based on a Central Station which receives the detector information from distributed readout electronics. Data from each RPC are acquired from a Receiver Card which reads out and digitizes the space and time information from 10 pick-up pads and gives out the pad multiplicity for trigger purposes. The Receiver Cards are hosted in Local Stations which Group 12 RPCs. On trigger occurrence, each Local Station sends the collected data to the Central Station. Both the detector and the electronics allow 1 ns accuracy in time measurements. In this work a detailed description of the Local Station and the Trigger System are presented.

  15. Proton-air cross section measurement with the ARGO-YBJ cosmic ray experiment

    SciTech Connect

    Aielli, G.; Camarri, P.; Iuppa, R.; Santonico, R.; Bacci, C.; Bussino, S.; Celio, P.; De Vincenzi, M.; James, I.; Mari, S. M.; Montini, P.; Pistilli, P.; Bartoli, B.; Bernardini, P.; Bleve, C.; De Mitri, I.; Mancarella, G.; Martello, D.; Zizzi, G.; Bi, X. J.

    2009-11-01

    The proton-air cross section in the energy range 1-100 TeV has been measured by the ARGO-YBJ cosmic ray experiment. The analysis is based on the primary cosmic ray flux attenuation for different atmospheric depths (i.e. zenith angles) and exploits the detector capabilities of selecting the shower development stage by means of hit multiplicity, density and lateral profile measurements at ground. The effects of shower fluctuations, the contribution of heavier primaries and the uncertainties of the hadronic interaction models, have been taken into account. The results have been used to estimate the total proton-proton cross section at center-of-mass energies between 70 and 500 GeV, where no accelerator data are currently available.

  16. Measurement of the proton-air cross section with ARGO-YBJ

    NASA Astrophysics Data System (ADS)

    De Mitri, I.; ARGO-YBJ Collaboration

    2009-12-01

    In this work the results of p-air cross section measurements with the ARGO-YBJ experiment are reported. The analysis is based on the different flux attenuation for different atmospheric depths (i.e. zenith angles), by exploiting the detector capabilities in selecting the shower development stage by means of the size, hit density and lateral profile measurements. The systematic errors introduced by fluctuations in shower development and heavier primaries have been taken into account. The results can give useful insights on p-air interactions at energies where hadronic interaction models start to give significantly different expectations and allow to infer the p-p total cross section in the energy region ( √{s}=80 GeV-500 GeV) not covered by experiments at accelerators.

  17. Overview of the ARGOS X-ray framing camera for Laser MegaJoule

    SciTech Connect

    Trosseille, C. Aubert, D.; Auger, L.; Bazzoli, S.; Brunel, P.; Burillo, M.; Chollet, C.; Jasmin, S.; Maruenda, P.; Moreau, I.; Oudot, G.; Raimbourg, J.; Soullié, G.; Stemmler, P.; Zuber, C.; Beck, T.; Gazave, J.

    2014-11-15

    Commissariat à l’Énergie Atomique et aux Énergies Alternatives has developed the ARGOS X-ray framing camera to perform two-dimensional, high-timing resolution imaging of an imploding target on the French high-power laser facility Laser MegaJoule. The main features of this camera are: a microchannel plate gated X-ray detector, a spring-loaded CCD camera that maintains proximity focus in any orientation, and electronics packages that provide remotely-selectable high-voltages to modify the exposure-time of the camera. These components are integrated into an “air-box” that protects them from the harsh environmental conditions. A miniaturized X-ray generator is also part of the device for in situ self-testing purposes.

  18. Context-dependent enhancer selection confers alternate modes of notch regulation on argos.

    PubMed

    Housden, Benjamin E; Terriente-Felix, Ana; Bray, Sarah J

    2014-02-01

    Wiring between signaling pathways differs according to context, as exemplified by interactions between Notch and epidermal growth factor receptor (EGFR) pathways, which are cooperative in some contexts but antagonistic in others. To investigate mechanisms that underlie different modes of cross talk, we have focused on argos, an EGFR pathway regulator in Drosophila melanogaster which is upregulated by Notch in adult muscle progenitors but is repressed in the wing. Results show that the alternate modes of cross talk depend on the engagement of enhancers with opposite regulatory logic, which are selected by context-determining factors. This is likely to be a general mechanism for enabling the wiring between these pathways to switch according to context.

  19. Control of on-orbit contamination for the Argos (P91-1) satellite

    NASA Technical Reports Server (NTRS)

    Kelley, Joseph G.

    1992-01-01

    The ARGOS (P91-1) satellite presents a challenging combination of on-orbit contamination concerns while mandating a low-cost approach. Several experiment payloads contain contamination sensitive optics, another contains large quantities of CO2 and Xe for release in orbit, and one contains an NH3 fueled arc jet thruster. The latter includes a suite of sensors to measure contamination; so prelaunch calculations will be tested. Planned contamination control techniques include: physical separation of sensitive surfaces from contamination sources; flight covers to protect sensitive surfaces during early outgassing on-orbit; gas release and thruster operation early in the flight, before flight covers are opened; and careful control of plumes and venting through a detailed analysis of each.

  20. Overview of the ARGOS X-ray framing camera for Laser MegaJoule.

    PubMed

    Trosseille, C; Aubert, D; Auger, L; Bazzoli, S; Beck, T; Brunel, P; Burillo, M; Chollet, C; Gazave, J; Jasmin, S; Maruenda, P; Moreau, I; Oudot, G; Raimbourg, J; Soullié, G; Stemmler, P; Zuber, C

    2014-11-01

    Commissariat à l'Énergie Atomique et aux Énergies Alternatives has developed the ARGOS X-ray framing camera to perform two-dimensional, high-timing resolution imaging of an imploding target on the French high-power laser facility Laser MegaJoule. The main features of this camera are: a microchannel plate gated X-ray detector, a spring-loaded CCD camera that maintains proximity focus in any orientation, and electronics packages that provide remotely-selectable high-voltages to modify the exposure-time of the camera. These components are integrated into an "air-box" that protects them from the harsh environmental conditions. A miniaturized X-ray generator is also part of the device for in situ self-testing purposes.

  1. Overview of the ARGOS X-ray framing camera for Laser MegaJoulea)

    NASA Astrophysics Data System (ADS)

    Trosseille, C.; Aubert, D.; Auger, L.; Bazzoli, S.; Beck, T.; Brunel, P.; Burillo, M.; Chollet, C.; Gazave, J.; Jasmin, S.; Maruenda, P.; Moreau, I.; Oudot, G.; Raimbourg, J.; Soullié, G.; Stemmler, P.; Zuber, C.

    2014-11-01

    Commissariat à l'Énergie Atomique et aux Énergies Alternatives has developed the ARGOS X-ray framing camera to perform two-dimensional, high-timing resolution imaging of an imploding target on the French high-power laser facility Laser MegaJoule. The main features of this camera are: a microchannel plate gated X-ray detector, a spring-loaded CCD camera that maintains proximity focus in any orientation, and electronics packages that provide remotely-selectable high-voltages to modify the exposure-time of the camera. These components are integrated into an "air-box" that protects them from the harsh environmental conditions. A miniaturized X-ray generator is also part of the device for in situ self-testing purposes.

  2. Fine-scale tracking of marine turtles using GPS-Argos PTTs.

    PubMed

    Yasuda, Tohya; Arai, Nobuaki

    2005-05-01

    High-accuracy location data of wildlife telemetry using conventional satellite location systems are difficult to obtain. However, such data are necessary to clarify the nature of movements and home range sizes of animals. In order to measure the high-accuracy location data, we developed new GPS-Argos Platform Terminal Transmitters (PTTs) which transmit both the conventional location and GPS location simultaneously. Two experiments, one in an artificial rearing pond and the other in the open sea, were performed. First, two hawksbill turtles were tracked with the PTTs in a 5 ha breeding pond in Thailand. Their home ranges using both data were calculated and found to be 2.96 ha and 0.93 ha by the GPS data, and 156,740 ha and 184,478 ha by a conventional data. Secondly, a female green turtle attached with the GPS-Argos was released from the coast of Pangnga Province, Thailand. There was a relationship between depth and speed of travel based on the GPS data. The data from the PTT showed that the turtle moved south along the coastline at the depth of less than 20 m for 5 days, and then stayed at a depth of less than 10 m for 4 days. However, we could not find any clear relationship using conventional data. Only a meandering movement at a variety of depths was observed. The results of the two experiments indicated the PTTs have an enormous potential for enhancing our understanding of fine-scale movement patterns and home ranges of marine turtles.

  3. Error Properties of Argos Satellite Telemetry Locations Using Least Squares and Kalman Filtering

    PubMed Central

    Boyd, Janice D.; Brightsmith, Donald J.

    2013-01-01

    Study of animal movements is key for understanding their ecology and facilitating their conservation. The Argos satellite system is a valuable tool for tracking species which move long distances, inhabit remote areas, and are otherwise difficult to track with traditional VHF telemetry and are not suitable for GPS systems. Previous research has raised doubts about the magnitude of position errors quoted by the satellite service provider CLS. In addition, no peer-reviewed publications have evaluated the usefulness of the CLS supplied error ellipses nor the accuracy of the new Kalman filtering (KF) processing method. Using transmitters hung from towers and trees in southeastern Peru, we show the Argos error ellipses generally contain <25% of the true locations and therefore do not adequately describe the true location errors. We also find that KF processing does not significantly increase location accuracy. The errors for both LS and KF processing methods were found to be lognormally distributed, which has important repercussions for error calculation, statistical analysis, and data interpretation. In brief, “good” positions (location codes 3, 2, 1, A) are accurate to about 2 km, while 0 and B locations are accurate to about 5–10 km. However, due to the lognormal distribution of the errors, larger outliers are to be expected in all location codes and need to be accounted for in the user’s data processing. We evaluate five different empirical error estimates and find that 68% lognormal error ellipses provided the most useful error estimates. Longitude errors are larger than latitude errors by a factor of 2 to 3, supporting the use of elliptical error ellipses. Numerous studies over the past 15 years have also found fault with the CLS-claimed error estimates yet CLS has failed to correct their misleading information. We hope this will be reversed in the near future. PMID:23690980

  4. Error properties of Argos satellite telemetry locations using least squares and Kalman filtering.

    PubMed

    Boyd, Janice D; Brightsmith, Donald J

    2013-01-01

    Study of animal movements is key for understanding their ecology and facilitating their conservation. The Argos satellite system is a valuable tool for tracking species which move long distances, inhabit remote areas, and are otherwise difficult to track with traditional VHF telemetry and are not suitable for GPS systems. Previous research has raised doubts about the magnitude of position errors quoted by the satellite service provider CLS. In addition, no peer-reviewed publications have evaluated the usefulness of the CLS supplied error ellipses nor the accuracy of the new Kalman filtering (KF) processing method. Using transmitters hung from towers and trees in southeastern Peru, we show the Argos error ellipses generally contain <25% of the true locations and therefore do not adequately describe the true location errors. We also find that KF processing does not significantly increase location accuracy. The errors for both LS and KF processing methods were found to be lognormally distributed, which has important repercussions for error calculation, statistical analysis, and data interpretation. In brief, "good" positions (location codes 3, 2, 1, A) are accurate to about 2 km, while 0 and B locations are accurate to about 5-10 km. However, due to the lognormal distribution of the errors, larger outliers are to be expected in all location codes and need to be accounted for in the user's data processing. We evaluate five different empirical error estimates and find that 68% lognormal error ellipses provided the most useful error estimates. Longitude errors are larger than latitude errors by a factor of 2 to 3, supporting the use of elliptical error ellipses. Numerous studies over the past 15 years have also found fault with the CLS-claimed error estimates yet CLS has failed to correct their misleading information. We hope this will be reversed in the near future.

  5. Merging altimeter data with Argo profiles to improve observation of tropical Pacific thermocline circulation and ENSO

    NASA Astrophysics Data System (ADS)

    Zhang, D.; Lee, T.; Wang, F.; McPhaden, M. J.; Kessler, W. S.

    2016-12-01

    Meridional thermocline currents play an important role in the recharge and discharge of tropical Pacific warm water during the development and transition of ENSO cycles. Previous analyses have shown large variations of the equatorward meridional thermocline convergence/divergence on ENSO and decadal time scales in the interior ocean. The total convergence/divergence is however unknown due to the lack of long term observation in the western boundary currents. Numerical modelling studies suggested a tendency of compensation between the interior and western boundary currents, but the exact compensation is model dependent. While Argo floats provide reasonable data coverage in the interior ocean, few floats are in the western boundary currents. Recent multi-mission satellite altimeter data and advanced processing techniques have resulted in higher resolution sea surface height anomaly (SSHA) products with better accuracy closer to the coasts. This study utilizes the statistical relationship between Argo dynamic height profiles and altimeter SSHA to calculate geostrophic thermocline currents in both the interior ocean and the western boundary of the tropical Pacific. The derived thermocline currents in the western boundary are validated by a 3.5-year moored Acoustic Doppler Current Profiler (ADCP) measurement in the Mindanao Current and by a series of glider surveys (Davis et al. 2012) in the Solomon Sea. The meridional transport timeseries of the interior and western boundary currents in the thermocline show different lead-lag relationships to the Nino 3.4 index. Results will be discussed in the context of recent 2014-2015 El Nino development and the potential contribution to the Tropical Pacific Observing System (TPOS).

  6. Using BioMart as a framework to manage and query pancreatic cancer data.

    PubMed

    Cutts, Rosalind J; Gadaleta, Emanuela; Lemoine, Nicholas R; Chelala, Claude

    2011-01-01

    We describe the Pancreatic Expression Database (PED), the first cancer database originally designed based on the BioMart infrastructure. The PED portal brings together multidimensional pancreatic cancer data from the literature including genomic, proteomic, miRNA and gene expression profiles. Based on the BioMart 0.7 framework, the database is easily integrated with other BioMart-compliant resources, such as Ensembl and Reactome, to give access to a wide range of annotations alongside detailed experimental conditions. This article is intended to give an overview of PED, describe its data content and work through examples of how to successfully mine and integrate pancreatic cancer data sets and other BioMart resources.

  7. Using BioMart as a framework to manage and query pancreatic cancer data

    PubMed Central

    Cutts, Rosalind J.; Gadaleta, Emanuela; Lemoine, Nicholas R.; Chelala, Claude

    2011-01-01

    We describe the Pancreatic Expression Database (PED), the first cancer database originally designed based on the BioMart infrastructure. The PED portal brings together multidimensional pancreatic cancer data from the literature including genomic, proteomic, miRNA and gene expression profiles. Based on the BioMart 0.7 framework, the database is easily integrated with other BioMart-compliant resources, such as Ensembl and Reactome, to give access to a wide range of annotations alongside detailed experimental conditions. This article is intended to give an overview of PED, describe its data content and work through examples of how to successfully mine and integrate pancreatic cancer data sets and other BioMart resources. Database URL: http://www.pancreasexpression.org PMID:21666272

  8. Clinical Trials Using Adenovirus Encoding Tyrosinase/MART-1/MAGEA6-transduced Autologous Dendritic Cell Vaccine

    Cancer.gov

    NCI supports clinical trials that test new and more effective ways to treat cancer. Find clinical trials studying adenovirus encoding tyrosinase/mart-1/magea6-transduced autologous dendritic cell vaccine.

  9. BioMart: a data federation framework for large collaborative projects.

    PubMed

    Zhang, Junjun; Haider, Syed; Baran, Joachim; Cros, Anthony; Guberman, Jonathan M; Hsu, Jack; Liang, Yong; Yao, Long; Kasprzyk, Arek

    2011-01-01

    BioMart is a freely available, open source, federated database system that provides a unified access to disparate, geographically distributed data sources. It is designed to be data agnostic and platform independent, such that existing databases can easily be incorporated into the BioMart framework. BioMart allows databases hosted on different servers to be presented seamlessly to users, facilitating collaborative projects between different research groups. BioMart contains several levels of query optimization to efficiently manage large data sets and offers a diverse selection of graphical user interfaces and application programming interfaces to ensure that queries can be performed in whatever manner is most convenient for the user. The software has now been adopted by a large number of different biological databases spanning a wide range of data types and providing a rich source of annotation available to bioinformaticians and biologists alike.

  10. BioMart: a data federation framework for large collaborative projects

    PubMed Central

    Zhang, Junjun; Haider, Syed; Baran, Joachim; Cros, Anthony; Guberman, Jonathan M.; Hsu, Jack; Liang, Yong; Yao, Long; Kasprzyk, Arek

    2011-01-01

    BioMart is a freely available, open source, federated database system that provides a unified access to disparate, geographically distributed data sources. It is designed to be data agnostic and platform independent, such that existing databases can easily be incorporated into the BioMart framework. BioMart allows databases hosted on different servers to be presented seamlessly to users, facilitating collaborative projects between different research groups. BioMart contains several levels of query optimization to efficiently manage large data sets and offers a diverse selection of graphical user interfaces and application programming interfaces to ensure that queries can be performed in whatever manner is most convenient for the user. The software has now been adopted by a large number of different biological databases spanning a wide range of data types and providing a rich source of annotation available to bioinformaticians and biologists alike. Database URL: http://www.biomart.org PMID:21930506

  11. The complete mitochondrial genome of sable, Martes zibellina.

    PubMed

    Xu, Chunzhu; Zhang, Honghai; Ma, Jianzhang; Liu, Zhonghua

    2012-06-01

    The complete mitogenome sequence of the Sable (NC_011579) was determined using long PCR (Polymerase Chain Reaction). The genome was 16,523 bp in length and contained 13 protein-coding genes, 2 rRNA genes, 22 tRNA genes and 1 control region. The gene composition and order of which was similar to most other mammals. The overall base composition of the heavy strand in descending order is A (32.0%), C (27. 6%), T (25.8%) and G (14.7%). The base compositions present clearly the A-C skew, which is most obviously in the control region and protein-coding genes. The extended termination-associated sequence domain, the central conserved domain, and the conserved sequence block domain are defined in the mitochondrial genome control region of Sable. This mitogenome sequence data would play an important role in phylogenetics and systematics of Martes zibellina.

  12. Seed oil composition of Paullinia cupana var. sorbilis (Mart.) Ducke.

    PubMed

    Avato, P; Pesante, M A; Fanizzi, F P; Santos, C Aimbiré de Moraes

    2003-07-01

    The chemical composition of the oil extracted from the seeds of Paullinia cupana var. sorbilis (Mart.) Ducke (syn. P. sorbilis) was investigated. Cyanolipids constituted 3% of the total oil from guaraná seeds, whereas acylglycerols accounted for 28%. 1H and 13C NMR analyses indicated that type I cyanolipids (1-cyano-2-hydroxymethylprop-2-ene-1-ol diesters) are present in the oil from P. cupana. GC and GC-MS analysis showed that cis-11-octadecenoic (cis-vaccenic acid) and cis-11-eicosenoic acids were the main FA (30.4 and 38.7%) esterified to the nitrile group. Paullinic acid (7.0%) was also an abundant component. Oleic acid (37.4%) was the dominant fatty acyl chain in the acylglycerols.

  13. Dispersal and genetic structure in the American marten, Martes americana.

    PubMed

    Broquet, T; Johnson, C A; Petit, E; Thompson, I; Burel, F; Fryxell, J M

    2006-05-01

    Natal dispersal in a vagile carnivore, the American marten (Martes americana), was studied by comparing radio-tracking data and microsatellite genetic structure in two populations occupying contrasting habitats. The genetic differentiation determined among groups of individuals using F(ST) indices appeared to be weak in both landscapes, and showed no increase with geographical distance. Genetic structure investigated using pairwise genetic distances between individuals conversely showed a pattern of isolation by distance (IBD), but only in the population occurring in a homogeneous high-quality habitat, therefore showing the advantage of individual-based analyses in detecting within-population processes and local landscape effects. The telemetry study of juveniles revealed a leptokurtic distribution of dispersal distances in both populations, and estimates of the mean squared parent-offspring axial distance (sigma2) inferred both from the genetic pattern of IBD and from the radio-tracking survey showed that most juveniles make little contribution to gene flow.

  14. Systemic AL amyloidosis in a Beech Marten (Martes foina).

    PubMed

    Scaglione, F E; Mignone, W; Ferrero, E; Poggi, M; Biolatti, B; Bollo, E

    2013-10-01

    A wild Beech Marten (Martes foina), was referred for necropsy to the Department of Animal Pathology of the University of Turin (Italy). At gross examination, whitish and firm masses, 10-mm in diameter, were found on the heart and in the kidney. Spleen showed lighter color and greater consistency, and the cut surface of the liver appeared scattered with whitish-yellow coalescing foci homogeneously distributed. Amyloid deposits were present in the perivascular and intercellular spaces of the visceral organs, such as the heart, liver, and kidneys. Amyloid stained positively with Congo red with and without 5% potassium permanganate pretreatment and showed green birefringence observable under polarized light. A diagnosis of systemic AL amyloidosis was made. This is the first description of systemic AL amyloidosis in a wild Stone Marten.

  15. eSciMart: Web Platform for Scientific Software Marketplace

    NASA Astrophysics Data System (ADS)

    Kryukov, A. P.; Demichev, A. P.

    2016-10-01

    In this paper we suggest a design of a web marketplace where users of scientific application software and databases, presented in the form of web services, as well as their providers will have presence simultaneously. The model, which will be the basis for the web marketplace is close to the customer-to-customer (C2C) model, which has been successfully used, for example, on the auction sites such as eBay (ebay.com). Unlike the classical model of C2C the suggested marketplace focuses on application software in the form of web services, and standardization of API through which application software will be integrated into the web marketplace. A prototype of such a platform, entitled eSciMart, is currently being developed at SINP MSU.

  16. Adenovirus MART-1-engineered autologous dendritic cell vaccine for metastatic melanoma.

    PubMed

    Butterfield, Lisa H; Comin-Anduix, Begonya; Vujanovic, Lazar; Lee, Yohan; Dissette, Vivian B; Yang, Jin-Quan; Vu, Hong T; Seja, Elizabeth; Oseguera, Denise K; Potter, Douglas M; Glaspy, John A; Economou, James S; Ribas, Antoni

    2008-04-01

    We performed a phase 1/2 trial testing the safety, toxicity, and immune response of a vaccine consisting of autologous dendritic cells (DCs) transduced with a replication-defective adenovirus (AdV) encoding the full-length melanoma antigen MART-1/Melan-A (MART-1). This vaccine was designed to activate MART-1-specific CD+8 and CD4+ T cells. Metastatic melanoma patients received 3 injections of 10(6) or 10(7) DCs, delivered intradermally. Cell surface phenotype and cytokine production of the DCs used for the vaccines were tested, and indicated intermediate maturity. CD8+ T-cell responses to MART-1 27-35 were assessed by both major histocompatibility complex class I tetramer and interferon (IFN)-gamma enzyme-linked immunosorbent spot (ELISPOT) before, during, and after each vaccine and CD4+ T-cell responses to MART-1 51-73 were followed by IFN-gamma ELISPOT. We also measured antigen response breadth. Determinant spreading from the immunizing antigen MART-1 to other melanoma antigens [gp100, tyrosinase, human melanoma antigen-A3 (MAGE-A3)] was assessed by IFN-gamma ELISPOT. Twenty-three patients were enrolled and 14 patients received all 3 scheduled DC vaccines. Significant CD8+ and/or CD4+ MART-1-specific T-cell responses were observed in 6/11 and 2/4 patients evaluated, respectively, indicating that the E1-deleted adenovirus encoding the cDNA for MART-1/Melan-A (AdVMART1)/DC vaccine activated both helper and killer T cells in vivo. Responses in CD8+ and CD4+ T cells to additional antigens were noted in 2 patients. The AdVMART1-transduced DC vaccine was safe and immunogenic in patients with metastatic melanoma.

  17. [The creation of transgenic tobacco plants expressing fragments of the ARGOS and NtEXPA4 genes in antisense orientation].

    PubMed

    Kuluev, B R; Kniazev, A V; Postrigan', B N; Chemeris, A V

    2014-01-01

    Transgenic tobacco plants expressing the fragments of the ARGOS and NtEXPA4 genes in antisense orientation have been created. Eleven lines of transgenic plants were investigated and five of them were characterized by a decrease in the sizes of the leaves and flowers as compared to control. Stalk sizes decreased when only the NtEXPA4 gene fragment was used. The organ size of the experimental plants decreased because of a reduction in the level of both cell division and cell expansion. Two lines of transgenic tobacco plants expressing the part of the ARGOS gene in antisense orientation were characterized by a reduction in the level of the NtEXPA1 and NtEXPA4 gene expression.

  18. Chlorophyll bloom in response to tropical cyclone Hudhud in the Bay of Bengal: Bio-Argo subsurface observations

    NASA Astrophysics Data System (ADS)

    Chacko, Neethu

    2017-06-01

    Though previous studies have documented substantial increases in chlorophyll concentrations as a result of cyclones, most of them were based on satellite observations dealing with surface chlorophyll blooms. This study documents the subsurface biological response and the subsequent chlorophyll bloom observed in response to the tropical cyclone Hudhud as evident from a Bio-Argo float located at the central Bay of Bengal. Results show high chlorophyll concentrations of up to 4.5 mg m-3 which is anomalous in the normally warm, stratified, and oligotrophic Bay of Bengal. The chlorophyll bloom is attributed to the combined effect of subsurface chlorophyll entrainment and nutrient injection. The presence of a pre-existing cyclonic eddy and the decreased translation speed of the cyclone over this region could have played a role in inducing the biological response. This is the first ever report to document the evolution of a subsurface chlorophyll bloom in response to cyclone forcing using Bio-Argo observations.

  19. [Population aspects of sexual dimorphism in guild of the Mustelidae: Mustela lutreola, Neovison vison, Mustela putorius, Martes martes as an example].

    PubMed

    Korablev, M P; Korablev, N P; Korablev, P N

    2013-01-01

    Size sexual dimorphism was investigated on 695 skulls of four Mustelidae species. By extent of increasing of differences between sexes the species are placed in following order: European pine marten (Martes martes), European mink (Mustela lutreola), American mink (Neovison vison), and European polecat (Mustela putorius). Extent of the dimorphism characterizes ecological plasticity of the species and is population characteristic. It is shown that M. martes takes specific and relatively narrow ecological niche of forest ecosystems, entering into weak competitive relationships with smaller Mustelidae species. The level of sexual dimorphism of M. lutreola, N. vison and M. putorius reflects intensity of its interspecific relationships within study area. High level of sexual dimorphism of M. putorius is determined by further divergence of ecological niches of males and females, and also appears to be compensatory mechanism reducing consequences of hardened environmental requirements.

  20. Practical experience with test-driven development during commissioning of the multi-star AO system ARGOS

    NASA Astrophysics Data System (ADS)

    Kulas, M.; Borelli, Jose Luis; Gässler, Wolfgang; Peter, Diethard; Rabien, Sebastian; Orban de Xivry, Gilles; Busoni, Lorenzo; Bonaglia, Marco; Mazzoni, Tommaso; Rahmer, Gustavo

    2014-07-01

    Commissioning time for an instrument at an observatory is precious, especially the night time. Whenever astronomers come up with a software feature request or point out a software defect, the software engineers have the task to find a solution and implement it as fast as possible. In this project phase, the software engineers work under time pressure and stress to deliver a functional instrument control software (ICS). The shortness of development time during commissioning is a constraint for software engineering teams and applies to the ARGOS project as well. The goal of the ARGOS (Advanced Rayleigh guided Ground layer adaptive Optics System) project is the upgrade of the Large Binocular Telescope (LBT) with an adaptive optics (AO) system consisting of six Rayleigh laser guide stars and wavefront sensors. For developing the ICS, we used the technique Test- Driven Development (TDD) whose main rule demands that the programmer writes test code before production code. Thereby, TDD can yield a software system, that grows without defects and eases maintenance. Having applied TDD in a calm and relaxed environment like office and laboratory, the ARGOS team has profited from the benefits of TDD. Before the commissioning, we were worried that the time pressure in that tough project phase would force us to drop TDD because we would spend more time writing test code than it would be worth. Despite this concern at the beginning, we could keep TDD most of the time also in this project phase This report describes the practical application and performance of TDD including its benefits, limitations and problems during the ARGOS commissioning. Furthermore, it covers our experience with pair programming and continuous integration at the telescope.

  1. The Argos-CLS Kalman Filter: Error Structures and State-Space Modelling Relative to Fastloc GPS Data

    PubMed Central

    Lowther, Andrew D.; Lydersen, Christian; Fedak, Mike A.; Lovell, Phil; Kovacs, Kit M.

    2015-01-01

    Understanding how an animal utilises its surroundings requires its movements through space to be described accurately. Satellite telemetry is the only means of acquiring movement data for many species however data are prone to varying amounts of spatial error; the recent application of state-space models (SSMs) to the location estimation problem have provided a means to incorporate spatial errors when characterising animal movements. The predominant platform for collecting satellite telemetry data on free-ranging animals, Service Argos, recently provided an alternative Doppler location estimation algorithm that is purported to be more accurate and generate a greater number of locations that its predecessor. We provide a comprehensive assessment of this new estimation process performance on data from free-ranging animals relative to concurrently collected Fastloc GPS data. Additionally, we test the efficacy of three readily-available SSM in predicting the movement of two focal animals. Raw Argos location estimates generated by the new algorithm were greatly improved compared to the old system. Approximately twice as many Argos locations were derived compared to GPS on the devices used. Root Mean Square Errors (RMSE) for each optimal SSM were less than 4.25km with some producing RMSE of less than 2.50km. Differences in the biological plausibility of the tracks between the two focal animals used to investigate the utility of SSM highlights the importance of considering animal behaviour in movement studies. The ability to reprocess Argos data collected since 2008 with the new algorithm should permit questions of animal movement to be revisited at a finer resolution. PMID:25905640

  2. The Argos-CLS Kalman Filter: Error Structures and State-Space Modelling Relative to Fastloc GPS Data.

    PubMed

    Lowther, Andrew D; Lydersen, Christian; Fedak, Mike A; Lovell, Phil; Kovacs, Kit M

    2015-01-01

    Understanding how an animal utilises its surroundings requires its movements through space to be described accurately. Satellite telemetry is the only means of acquiring movement data for many species however data are prone to varying amounts of spatial error; the recent application of state-space models (SSMs) to the location estimation problem have provided a means to incorporate spatial errors when characterising animal movements. The predominant platform for collecting satellite telemetry data on free-ranging animals, Service Argos, recently provided an alternative Doppler location estimation algorithm that is purported to be more accurate and generate a greater number of locations that its predecessor. We provide a comprehensive assessment of this new estimation process performance on data from free-ranging animals relative to concurrently collected Fastloc GPS data. Additionally, we test the efficacy of three readily-available SSM in predicting the movement of two focal animals. Raw Argos location estimates generated by the new algorithm were greatly improved compared to the old system. Approximately twice as many Argos locations were derived compared to GPS on the devices used. Root Mean Square Errors (RMSE) for each optimal SSM were less than 4.25 km with some producing RMSE of less than 2.50 km. Differences in the biological plausibility of the tracks between the two focal animals used to investigate the utility of SSM highlights the importance of considering animal behaviour in movement studies. The ability to reprocess Argos data collected since 2008 with the new algorithm should permit questions of animal movement to be revisited at a finer resolution.

  3. Evaluation of mid-depth currents of NCEP reanalysis data in the tropical Pacific using ARGO float position information

    NASA Astrophysics Data System (ADS)

    Xie, Jiping; Zhu, Jiang; Xu, Li; Guo, Pinwen

    2005-09-01

    The global project of the Array for Real-time Geostrophic Oceanography (ARGO) provides a unique opportunity to observe the absolute velocity in mid-depths of the world oceans. A total of 1597 velocity vectors at 1000 (2000) db in the tropical Pacific derived from the ARGO float position information during the period November 2001 to October 2004 are used to evaluate the intermediate currents of the National Centers for Environmental Prediction reanalysis. To derive reliable velocity information from ARGO float trajectory points, a rigorous quality control scheme is applied, and by virtue of a correction method for reducing the drift error on the surface in obtaining the velocity vectors, their relative errors are less than 25%. Based on the comparisons from the quantitative velocity vectors and from the space-time average currents, some substantial discrepancies are revealed. The first is that the velocities of the reanalysis at mid-depths except near the equator are underestimated relative to the observed velocities by the floats. The average speed difference between NCEP and ARGO values ranges from about -2.3 cms-1 to -1.8 cm s-1. The second is that the velocity difference between the ocean model and the observations at 2000 dB seems smaller than that at 1000 dB. The third is that the zonal flow in the reanalysis is too dominant so that some eddies could not be simulated, such as the cyclonic eddy to the east of 160°E between 20°N and 30°N at 2000 dB. In addition, it is noticeable that many floats parking at 1000 dB cannot acquire credible mid-depth velocities due to the time information of their end of ascent (start of descent) on the surface in the trajectory files. Thus, relying on default times of parking, descent and ascent in the metadata files gravely confines their application to measuring mid-depth currents.

  4. The Argo Project: Global Ocean Observations for Understanding and Prediction of Climate Variability. Report for Calendar Year 2005

    DTIC Science & Technology

    2005-01-01

    environment of ocean ecosystems. Over 90% of the increased heat content due to global warming of the air/sea/ice climate system in the past 40...years occurred in the oceans. Climate stresses on ocean ecosystems have serious consequences, and sometimes dramatic ones, such as coral reef bleaching ...The Argo Project Global Ocean Observations for Understanding and Prediction of Climate Variability Report for Calendar Year 2005 Dean H

  5. The ARGO Project: Global Ocean Observations for Understanding and Prediction of Climate Variability. Report for Calendar Year 2004

    DTIC Science & Technology

    2004-01-01

    Over 90% of the increased heat content due to global warming of the air/sea/ice climate system in the past 40 years occurred in the oceans. Climate...stresses on ocean ecosystems have serious consequences, and sometimes dramatic ones, such as coral reef bleaching . In the future, the impacts of a...The Argo Project Global Ocean Observations for Understanding and Prediction of Climate Variability Report for Calendar Year 2004 Dean H

  6. The USA experiment on the Argos Satellite: A low cost instrument for timing x-ray binaries

    SciTech Connect

    Wood, K.S.; Fritz, G.; Hertz, P.; Johnson, W.N.; Lovelette, M.N.; Wolff, M.T. ); Bloom, E.; Godfrey, G.; Hanson, J.; Michelson, P.; Taylor, R.; Wen, H. )

    1994-07-05

    The Unconventional Stellar Aspect (USA) experiment to be launched in September 1995 on the Advanced Research and Global Observations Satellite (ARGOS) is a low-cost, quick---yet scientifically ambitious---x-ray timing experiment. It is designed for the dual purpose of scientific research in x-ray timing and time resolved spectroscopy and also for exploration of applications of x-ray sensor technology. Bright galactic x-ray binaries are used simultaneously for both scientific and applied objectives.

  7. Hydrodynamic features of the South Aegean Sea as derived from Argo T/ S and dissolved oxygen profiles in the area

    NASA Astrophysics Data System (ADS)

    Kassis, Dimitris; Krasakopoulou, Evangelia; Korres, Gerasimos; Petihakis, George; Triantafyllou, George S.

    2016-11-01

    In this work, the hydrodynamic picture of the South Aegean Sea is examined through an analysis of recent measurements in its sub-basins, the Myrtoan and Cretan Sea. Both sub-basins play an important role in the water circulation, exchange, and formation processes that affect the dynamics of the whole Eastern Mediterranean. For the first time, Bio-Argo floats were deployed in the area under the Greek Argo Research Infrastructure coordination. The acquired profiles cover an almost 2-year period (November 2013-July 2015) and are compared with previous Argo profiles and the re-processed time-series data recorded from the E1-M3A POSEIDON observatory operating in the area since 2007. The spatio-temporal distribution of the physical and chemical properties in each sub-basin is examined. Dense water formation events are revealed in the northern part (Myrtoan), while the wider area can be characterized as pre-conditioned. In the Cretan basin, a strong inter-annual variability of the salinity field at intermediate and deep layers is observed that is associated with water exchange from its open boundaries. Furthermore, comparison of the dissolved oxygen (DO) distribution with physical water properties within both the mixed layer, and at greater depths, indicated that relatively high but still under-saturated DO values are more likely to be associated with convection events. Finally, an updated picture of the physical properties and the DO distribution is presented based on the last 5 years of measurements and the recent introduction of Bio-Argo floats with DO sensors in the area.

  8. Arabidopsis ORGAN SIZE RELATED1 regulates organ growth and final organ size in orchestration with ARGOS and ARL.

    PubMed

    Feng, Guanping; Qin, Zhixiang; Yan, Jingzhou; Zhang, Xiaoran; Hu, Yuxin

    2011-08-01

    • The growth of a plant organ to its characteristic size is regulated by an elaborate developmental program involving both internal and external signals. Here, we identify a novel Arabidopsis gene, ORGAN SIZE RELATED1 (OSR1), that is involved in regulation of organ growth and overall organ size. • A combination of genetic, cytological and molecular approaches was used to characterize the expression profile, subcellular localization and roles of OSR1 during organ growth. • Ectopic expression of OSR1 in Arabidopsis resulted in enlarged organs, as a consequence of increases in both cell number and cell size. OSR1 shares a conserved OSR domain with ARGOS and ARGOS-LIKE (ARL), which is sufficient for their functions in promoting organ growth. OSR1 is a plant hormone-responsive gene and appears to act redundantly with ARGOS and ARL during organ growth. The OSR proteins are localized to the endoplasmic reticulum. • Our results suggest that three co-evolved members of the OSR family may act coordinately to orchestrate growth signals and cell proliferation and expansion, thereby affecting organ growth and final organ size.

  9. Identification of the TeV gamma-ray source ARGO J2031+4157 with the Cygnus Cocoon

    SciTech Connect

    Bartoli, B.; Catalanotti, S.; D'Ettorre Piazzoli, B.; Di Girolamo, T.; Bernardini, P.; D'Amone, A.; De Mitri, I.; Bi, X. J.; Cao, Z.; Chen, S. Z.; Branchini, P.; Budano, A.; Camarri, P.; Cardarelli, R.; Di Sciascio, G.; Chen, T. L.; Danzengluobu; Creti, P.; Cui, S. W.; Dai, B. Z.; Collaboration: ARGO-YBJ Collaboration; and others

    2014-08-01

    The extended TeV gamma-ray source ARGO J2031+4157 (or MGRO J2031+41) is positionally consistent with the Cygnus Cocoon discovered by Fermi-LAT at GeV energies in the Cygnus superbubble. Reanalyzing the ARGO-YBJ data collected from 2007 November to 2013 January, the angular extension and energy spectrum of ARGO J2031+4157 are evaluated. After subtracting the contribution of the overlapping TeV sources, the ARGO-YBJ excess map is fitted with a two-dimensional Gaussian function in a square region of 10° × 10°, finding a source extension σ{sub ext}= 1.°8 ± 0.°5. The observed differential energy spectrum is dN/dE = (2.5 ± 0.4) × 10{sup –11}(E/1 TeV){sup –2.6±0.3} photons cm{sup –2} s{sup –1} TeV{sup –1}, in the energy range 0.2-10 TeV. The angular extension is consistent with that of the Cygnus Cocoon as measured by Fermi-LAT and the spectrum also shows a good connection with the one measured in the 1-100 GeV energy range. These features suggest to identify ARGO J2031+4157 as the counterpart of the Cygnus Cocoon at TeV energies. The Cygnus Cocoon, located in the star-forming region of Cygnus X, is interpreted as a cocoon of freshly accelerated cosmic rays related to the Cygnus superbubble. The spectral similarity with supernova remnants (SNRs) indicates that the particle acceleration inside a superbubble is similar to that in an SNR. The spectral measurements from 1 GeV to 10 TeV allows for the first time to determine the possible spectrum slope of the underlying particle distribution. A hadronic model is adopted to explain the spectral energy distribution.

  10. Development of new oxygen sensor for Argo profiling floats: Fast responsivity and long-term stability

    NASA Astrophysics Data System (ADS)

    Mori, K.; Takai, S. I.; Uchida, H.; Sato, K.; Hosoda, S.; Kobayashi, T.

    2016-02-01

    Dissolved oxygen (DO) is one of key parameters governing physical/biochemical processes in the ocean. JFE Advantech's RINKO series is widely known for markedly fast response optical DO sensors and can assist in revealing a small-scale DO structure, which will contribute to understanding new aspects of the processes. Long-term stability is of secondary importance for the conventional RINKO series and the highest accuracy is being maintained by a regular recalibration. Meanwhile, Argo profiling floats require satisfying a high accuracy for multiple years without a recalibration because the floats are generally not recovered and post-calibrated. The RINKO FT is a new member of the RINKO series and has overcome a well-known tradeoff between fast responsivity and stability of a DO sensing foil. The RINKO FT not only retains the fast response time (63%: less than 1 s in water) identical to that of conventional RINKO series but also has greater accuracy and stability by incorporating a high-quality multipoint calibration and improving the sensing method. Two MRV S3A floats with RINKO FT were launched in the northwestern Pacific Ocean in July 2014 and one of the floats is still operating in the field. The DO sampling interval was 2 dbar throughout the water column (from 2000 m to the surface) to take advantage of the fast responsivity. The RINKO FT data of the first dive agreed well with the Winkler titration data sampled near the dive point. The vertical high-resolution measurement detected thin layers with DO maximum/minimum in the subsurface. The linear trend of the DO data obtained from the RINKO FT indicates no significant time drift of less than 1 μmol/kg per year along a potential density of 27.6 σθ lying at a depth of 1600 - 1900 m. Although the RINKO FT is primarily designed to target Argo float operations, its compact, lightweight design and commonly used communication protocols widen the choice of platforms for installation.

  11. Final results from the space dust (SPADUS) instrument flown aboard the earth-orbiting ARGOS spacecraft

    NASA Astrophysics Data System (ADS)

    Tuzzolino, A. J.; Economou, T. E.; McKibben, R. B.; Simpson, J. A.; BenZvi, S.; Blackburn, L.; Voss, H. D.; Gursky, H.

    2005-08-01

    In this paper, we present the final report of the data obtained from the Space Dust (SPADUS) instrument on the Earth-orbiting Advanced Research and Global Observation Satellite (ARGOS). The University of Chicago's SPADUS instrument on the US Air Force's Advanced Research and Global Observation Satellite has been operating in a nearly polar orbit, at an altitude of approximately 850 km, since soon after its launch on day 54, 1999 (23 February) until termination of the SPADUS operations on day 248, 2001 (5 September). The instrument consists of a polyvinylidene fluoride (PVDF) dust trajectory system, which includes two planar arrays of PVDF sensors (a total of 16 sensors per array) separated by 20.25 cm to provide time of flight (TOF) measurements. The trajectory system measures dust particle flux, mass distribution, velocity and trajectory. The instrument also includes the SPADUS Ancillary Diagnostic Sensor (ADS) subsystem, which measured energetic charged particles (electrons, protons, etc). The PVDF dust trajectory system detected a total of 368 dust impacts over the SPADUS live-time interval of 739 days, yielding an average particle flux of 0.50 impacts/day. Of these 368 impacts, 35 were D1-D2 type events - where particles impacted and penetrated a D1 sensor, then impacted a D2 rear array sensor - allowing for time-of-flight measurements. Of the 35 D1-D2 impacts on SPADUS, we identified 19 D1-D2 impacts yielding TOF values. Of these 19 events, 14 were ambiguous (either bound or interplanetary) and 5 were unambiguous interplanetary impacts. Examples of particle orbits for debris particles as well as D1-D2 impacts are detailed. We also describe transient particle streams detected by the SPADUS trajectory system, resulting from the passage of ARGOS through streams of debris particles in Earth orbit. One of the streams was shown to result from detection by SPADUS of the debris generated by the explosion of a Chinese booster rocket. The SPADUS flight data accumulated

  12. Climatology and seasonality of upper ocean salinity: a three-dimensional view from argo floats

    NASA Astrophysics Data System (ADS)

    Chen, Ge; Peng, Lin; Ma, Chunyong

    2017-06-01

    Primarily due to the constraints of observation technologies (both field and satellite measurements), our understanding of ocean salinity is much less mature compared to ocean temperature. As a result, the characterizations of the two most important properties of the ocean are unfortunately out of step: the former is one generation behind the latter in terms of data availability and applicability. This situation has been substantially changed with the advent of the Argo floats which measure the two variables simultaneously on a global scale since early this century. The first decade of Argo-acquired salinity data are analyzed here in the context of climatology and seasonality, yielding the following main findings for the global upper oceans. First, the six well-defined "salty pools" observed around ±20° in each hemisphere of the Pacific, Atlantic and Indian Oceans are found to tilt westward vertically from the sea surface to about 600 m depth, forming six saline cores within the subsurface oceans. Second, while potential temperature climatology decreases monotonically to the bottom in most places of the ocean, the vertical distribution of salinity can be classified into two categories: A double-halocline type forming immediately above and below the local salinity maximum around 100-150 m depths in the tropical and subtropical oceans, and a single halocline type existing at about 100 m depth in the extratropical oceans. Third, in contrast to the midlatitude dominance for temperature, seasonal variability of salinity in the oceanic mixed layer has a clear tropical dominance. Meanwhile, it is found that a two-mode structure with annual and semiannual periodicities can effectively penetrate through the upper ocean into a depth of 2000 m. Fourth, signature of Rossby waves is identified in the annual phase map of ocean salinity within 200-600 m depths in the tropical oceans, revealing a strongly co-varying nature of ocean temperature and salinity at specific depths

  13. Depositional history, nannofossil biostratigraphy, and correlation of Argo Abyssal Plain Sites 765 and 261

    USGS Publications Warehouse

    Dumoulin, Julie A.; Bown, Paul R.

    1992-01-01

    Sediments from the Argo Abyssal Plain (AAP), northwest of Australia, are the oldest known from the Indian Ocean and were recovered from ODP Site 765 and DSDP Site 261. New biostratigraphic and sedimentologic data from these sites, as well as reinterpretations of earlier findings, indicate that basal sediments at both localities are of Late Jurassic age and delineate a history of starved sedimentation punctuated by periodic influx of calcareous pelagic turbidites.Biostratigraphy and correlation of Upper Jurassic-Lower Cretaceous sediments is based largely on calcareous nannofossils. Both sites yielded variably preserved nannofossil successions ranging from Tithonian to Hauterivian at Site 765 and Kimmeridgian to Hauterivian at Site 261. The nannofloras are comparable to those present in the European and Atlantic Boreal and Tethyan areas, but display important differences that reflect biogeographic differentiation. The Argo region is thought to have occupied a position at the southern limit of the Tethyan nannofloral realm, thus yielding both Tethyan and Austral biogeographic features.Sedimentary successions at the two sites are grossly similar, and differences largely reflect Site 765 's greater proximity to the continental margin. Jurassic sediments were deposited at rates of about 2 m/m.y. near the carbonate compensation depth (CCD) and contain winnowed concentrations of inoceramid prisms and nannofossils, redeposited layers rich in calcispheres and calcisphere debris, manganese nodules, and volcanic detritus. Lower Cretaceous and all younger sediments accumulated below the CCD at rates that were highest (about 20 m/m.y.) during mid-Cretaceous and Neogene time. Background sediment in this interval is noncalcareous claystone; turbidites dominate the sequence and are thicker and coarser grained at Site 765.AAP turbidites consist mostly of calcareous and siliceous biogenic components and volcanogenic smectite clay; they were derived from relatively deep parts of the

  14. On the nature of the Madagascar dipoles: An analysis from Argo profiling floats and altimetry measurements

    NASA Astrophysics Data System (ADS)

    Aguiar-González, Borja; Ponsoni, Leandro; Ridderinkhof, Herman; de Ruijter, Will P. M.; Maas, Leo R. M.

    2016-04-01

    The South East Madagascar Current (SEMC) flows poleward along the eastern coast of Madagascar as a western boundary current which further south provides some of the source waters of the Agulhas Current, either directly or in the form of eddies. We investigate the region of dipole formation south of Madagascar combining vertical T/S profiles from Argo floats, altimetry measurements and an existing eddy detection algorithm. Results from our analysis show that the dipole consists of an anticyclonic intrathermocline eddy (ITE) formed on its southern flank and a cyclonic ITE formed on its northern flank. Both lobes of the dipole exhibit similar T/S properties throughout the water column, although vertically shifted within the thermocline depending on its nature: upward in a cyclonic ITE and downward in an anticyclonic ITE. A subsurface salinity maximum of about 35.5 psu characterizes the upper layers with Subtropical Surface Water (STSW). At intermediate levels, a well defined path of South Indian Central Water (SICW) extends throughout the water column up to reach a minimum in salinity of 34.5 psu, corresponding to Antarctic Intermediate Water (AAIW). Below, at deep layers, the North Atlantic Deep Water (NADW) is found. The intrathermocline nature of the Madagascar dipoles has not been previously reported and represents an important feature to be considered when assessing the heat and salt fluxes driven by eddy movement and contributing to the Agulhas Current. Unlike surface eddies, intrathermocline eddies strongly influence the intermediate/deeper layers in the oceans and, hence, may have a larger contribution in the spreading rates and pathways of water masses. Because the intrathermocline nature of eddies is invisible to altimetry measurements, these results stress the importance of combining altimetry with historical records of Argo profiles which uncover eddy dynamics below the sea surface. Lastly, we further investigate from altimetry the area of dipole formation

  15. Mitochondrial genomes reveal the pattern and timing of marten (Martes), wolverine (Gulo), and fisher (Pekania) diversification.

    PubMed

    Li, Bo; Wolsan, Mieczyslaw; Wu, Dan; Zhang, Wei; Xu, Yanchun; Zeng, Zhaohui

    2014-11-01

    Despite recent advances in understanding the pattern and timescale of evolutionary diversification in the marten, wolverine, fisher, and tayra subfamily Guloninae (Mustelidae, Carnivora), several important issues still remain contentious. Among these are the phylogenetic position of Gulo relative to the subgenera of Martes (Martes and Charronia), the phylogenetic relationships within the subgenus Martes, and the timing of gulonine divergences. To elucidate these issues we explored nucleotide variation in 11 whole mitochondrial genomes (mitogenomes) from eight gulonine species and two outgroup meline species. Parsimony, maximum likelihood, and Bayesian phylogenetic analyses yielded fully resolved and identical patterns of relationships with high support for all divergences. The generic status of Pekania (P. pennanti), the monophyly of the genus Martes containing M. flavigula (subgenus Charronia) to the exclusion of the genus Gulo (G. gulo), and the M. foina (M. americana (M. melampus (M. zibellina, M. martes))) phylogeny of the subgenus Martes were strongly supported. Dating analyses (BEAST) using a set of five newly applied fossil calibrations provided divergence times considerably younger than previous multigene mitochondrial estimates, but similar to multigene nuclear and nuclear-mitochondrial estimates. The 95% confidence (highest posterior density) intervals of our divergence times fell within those inferred from nuclear and nuclear-mitochondrial sequence data, and were markedly narrower than in earlier studies (whether nuclear, mitochondrial, or combined). Notably, and contrary to long-held beliefs, our findings indicate that fossils older than the Tortonian-Messinian transition (late Late Miocene) do not represent Martes, excluding from this genus its putative members from the Early, Middle, and early Late Miocene. This study demonstrates the high informativeness of the mitogenome for phylogenetic inference and divergence time estimation within Guloninae, and

  16. Misexpression of argos, an inhibitor of EGFR signaling in oogenesis, leads to the production of bicephalic, ventralized, and lateralized Drosophila melanogaster eggs.

    PubMed

    Zhao, D; Bownes, M

    1999-01-01

    Epidermal growth factor receptor (EGFR) signaling pathways are frequently involved in generating cell fate diversity in a number of organisms. During anterior-posterior and dorso-ventral polarity in the Drosophila egg chamber and eggshell, EGFR signaling leads to a number of determinative events in the follicle cell layer. A high level of Gurken signal leads to the expression of argos in dorsal midline cells. Lateral follicle cells, receiving a lower level of Gurken signal, can continue to express the Broad-Complex (BR-C) and differentiate into cells which produce chorionic appendages. Misexpression of argos in mid-oogenesis causes the midline cells to retain expression of BR-C, resulting in a single fused large appendage. Evidence that argos can directly repress Gurken-induced EGFR signaling is seen when premature expression of argos is induced earlier in oogenesis. It represses the Gurken signal at stage 5-6 of oogenesis which determines posterior follicle cells and occasionally leads to eggs with anteriors at both ends. We propose that the Gurken signal at stage 9 of oogenesis induces follicle cells to take on two fates, dorsal midline and lateral, each producing different parts of the eggshell and that argos is one of the key downstream genes required to select between these two fates.

  17. A Bäcklund transformation between the four-dimensional Martínez Alonso-Shabat and Ferapontov-Khusnutdinova equations

    NASA Astrophysics Data System (ADS)

    Kruglikov, B. S.; Morozov, O. I.

    2016-09-01

    We find a Bäcklund transformation between the four-dimensional Martínez Alonso-Shabat and Ferapontov-Khusnutdinova equations. We also discuss an integrable deformation of the Martínez Alonso-Shabat equation.

  18. Identification of epitope mimics recognized by CTL reactive to the melanoma/melanocyte-derived peptide MART-1(27-35)

    PubMed Central

    1996-01-01

    CTL reactivity to the epitope MART-1(27-35), of the melanoma (self) antigen MART-1/melan A is frequently observed in tumor-infiltrating lymphocytes and may be readily elicited from the peripheral blood of melanoma patients that express HLA-A*0201. Available data suggest that these observations contrast with those made for other HLA-A*0201- presented melanoma self antigens regarding the regularity of observed CTL responses. Based on preliminary findings, we hypothesized that the CTL response to MART-1 might be augmented in part by T cell encounters with peptides derived from sources other than MART-1, which show sequence similarity to MART-1(27-35). To test this idea, a protein database search for potential MART-1 epitope mimics was done using criteria developed from analyses of effector recognition of singly- substituted peptide analogues of MART-1(27-35). Synthetic peptides were made for a portion of the sequences retrieved; 12/40 peptides tested were able to sensitize target cells for lysis by one or more anti-MART- 1 effectors. The peptides recognized correspond to sequences occurring in a variety of proteins of viral, bacterial, and human (self) origin. One peptide derives from glycoprotein C of the common pathogen HSV-1; cells infected with recombinant vaccinia virus encoding native glycoprotein C were lysed by anti-MART-1 effectors. Our results overall indicate that sequences conforming to the A2.1 binding motif and possessing features essential to recognition by anti-MART-1 CTL occur frequently in proteins. These findings further suggest that T cells might encounter a variety of such sequences in vivo, and that epitope mimicry may play a role in modulating the CTL response to MART-1(27-35). PMID:8760818

  19. Antineutrino-induced charge current quasi-elastic neutral hyperon production in ArgoNeuT

    NASA Astrophysics Data System (ADS)

    Farooq, Saima

    This dissertation presents the first topological study of the charge current quasi-elastic (CCQE) neutral hyperon production induced by antineutrinos in the ArgoNeuT detector, a liquid argon time projection chamber (LArTPC) at Fermilab, using 1.20 x 1020 protons-on- target (POT), in the NuMI beam operating in the low energy antineutrino mode. The total cross section for the CCQE neutral hyperon production is reported at the mean production energy of 3.42 GeV. The event yield in data is consistent with the predicted cross section, sigma = 2.7 x 10-40 cm2: sigma(CCQELambda0+Sigma0 ) = 3.7 +/- 1.9(stat.) +/- 1.5 (sys.) x 10 -40 cm2. The study sets a 90% confidence level (C.L.) upper limit on the total cross section of CCQE neutral hyperon production: sigma(CCQE Lambda0+Sigma0) < 7.3 x10-40 cm 2 at 90% C.L.

  20. Latest results on cosmic ray physics from the ARGO-YBJ experiment

    NASA Astrophysics Data System (ADS)

    De Mitri, Ivan

    2014-04-01

    Cosmic ray physics in the 1012-1015 eV primary energy range is among the main scientific goals of the ARGO-YBJ experiment. The detector, located in the Cosmic Ray Observatory of Yangbajing (Tibet, China) at 4300 m a.s.l., is a full coverage extensive air shower array consisting of a carpet of Resistive Plate Chambers (RPCs) distributed over an area of more than 10 000 m2. The apparatus layout, performance and location offer a unique opportunity for a detailed study of several characteristics of the hadronic component of the cosmic ray flux in an energy window marked by the transition from direct to indirect measurements. Moreover, the analog readout of the RPC signals indeed provides a powerful tool to study, with unprecedented resolution and without saturation, the extensive air shower space-time structure down to few meters from its axis. Latest results concerning the study of cosmic ray energy spectrum, mass composition and arrival directions will be given together with the search for an antiproton signal, the proton-air cross-section measurement, the study of the interplanetary magnetic field, and the effects of the geomagnetic field on secondary particles. Furthermore, particle distributions close to the shower axis are being extensively studied, also giving new inputs, in the very forward region, to the hadronic interaction models currently used for understanding particle physics and cosmic rays up to the highest energies.

  1. Background radioactivity in the scaler mode technique of the Argo-YBJ detector

    NASA Astrophysics Data System (ADS)

    Bolognino, I.; Cattaneo, C.; Giroletti, E.; Liguori, G.; Salvini, P.

    2011-08-01

    ARGO-YBJ is an extensive air shower detector located at the Yangbajing Cosmic Ray Laboratory (4300 m a.s.l., 606 g cm-2 atmospheric depth, Tibet, China). It is made by a single layer of Resistive Plate Chambers (RPCs, total surface ~6700 m2) grouped into 153 units called "clusters". The low energy threshold of the experiment is obtained using the "scaler operation mode", counting all the particles hitting the detector without reconstruction of the shower size and arrival direction. For each cluster the signals generated by these particles are put in coincidence in a narrow time window (150 ns) and read by four independent scaler channels, giving the counting rates of channel ≥1, ≥2, ≥3 and ≥4 hits. The study of these counting rates pointed out a different behavior of channel ≥1 respect to the higher multiplicity channels: while the MC simulations can account fairly well for the coincident counting rates, the expectation for channel ≥1 is sensibly less than the measured value. Moreover, the regression coefficient with the atmospheric pressure for channel ≥1 is also about half of the value measured for the coincident counting rates: seemingly half of these counts did not cross the atmosphere.Measurements of the natural radioactivity background in the air of the detector hall and a MC simulation to estimate its contribution on our counting rates are presented and discussed.

  2. Measurement of the Cosmic Ray spectra by the ARGO-YBJ experiment

    NASA Astrophysics Data System (ADS)

    Surdo, A.; ARGO-YBJ Collaboration

    2015-08-01

    Exploiting the features and location at high altitude (the Cosmic Ray Observatory of Yangbajing in Tibet, China, at about 4,300 m a.s.l.) of the ARGO-YBJ detector, the study of several aspects concerning cosmic ray physics in the primary energy region 1012-1016 eV has been performed. Here, the preliminary results of the measurement of all-particle and light-component (i.e. protons and helium nuclei) energy spectra between few tens TeV and ˜5 PeV will be reported, as obtained from the data of RPC (Resistive Plate Chamber) analog charge readout. The study of such energy region is particularly important to better understand the so called knee of the energy spectrum and its origin, as well as for a powerful cross-check among very different experimental techniques, like balloon/space-borne spectrometers and surface air shower detectors. It also allows to test the hadronic interaction models currently used for investigating particle and cosmic ray physics up the highest energies. Finally, the precise measurements of the cosmic ray energy spectrum and composition make possible a more reliable estimation of the atmospheric neutrino flux, which is crucial for any extra-terrestrial neutrino search.

  3. Observing the subsurface thermal signature of the Black Sea cold intermediate layer with Argo profiling floats

    NASA Astrophysics Data System (ADS)

    Akpinar, Anil; Fach, Bettina A.; Oguz, Temel

    2017-06-01

    Cold intermediate layers (CILs) constitute a key indicator of the subsurface thermal signature in many marginal and subarctic seas. Towards better understanding the impacts of natural and anthropogenic climate variability in the Black Sea, the present study elucidates processes leading to the observed changes of CIL characteristics at mesoscale and monthly-to-interannual scales by analyzing weekly temperature-salinity profiles provided by Argo floats for 2002-2015. The continuous time series data allowed to elucidate different types of CIL formation episodes. For the first time, it was possible to trace their subsequent evolution depending on the number and intensity of successive, but often intermittent, autumn-winter cooling events in addition to the ambient flow and stratification characteristics within the cyclonic interior and anticyclonic coastal eddies/gyres. The spatial distribution of CIL formation in the cold years 2003, 2006 and 2012 covered much of the Black Sea, even coastal anticyclonic eddies as a new feature which has not been documented before. The data also recorded modification of CIL during the rest of the year in terms of its thickness, position, temperature and salinity ranges in response to advective transport by the circulation system, interior turbulent mixing, and quasi-lateral intrusions associated with mesoscale features.

  4. Maize ARGOS1 (ZAR1) transgenic alleles increase hybrid maize yield

    PubMed Central

    Guo, Mei

    2014-01-01

    Crop improvement for yield and drought tolerance is challenging due to the complex genetic nature of these traits and environmental dependencies. This study reports that transgenic over-expression of Zea mays ARGOS1 (ZAR1) enhanced maize organ growth, grain yield, and drought-stress tolerance. The ZAR1 transgene exhibited environmental interactions, with yield increase under Temperate Dry and yield reduction under Temperate Humid or High Latitude environments. Native ZAR1 allele variation associated with drought-stress tolerance. Two founder alleles identified in the mid-maturity germplasm of North America now predominate in Pioneer’s modern breeding programme, and have distinct proteins, promoters and expression patterns. These two major alleles show heterotic group partitioning, with one predominant in Pioneer’s female and the other in the male heterotic groups, respectively. These two alleles also associate with favourable crop performance when heterozygous. Allele-specific transgene testing showed that, of the two alleles discussed here, each allele differed in their impact on yield and environmental interactions. Moreover, when transgenically stacked together the allelic pair showed yield and environmental performance advantages over either single allele, resembling heterosis effects. This work demonstrates differences in transgenic efficacy of native alleles and the differences reflect their association with hybrid breeding performance. PMID:24218327

  5. A mitogenomic phylogeny and genetic history of sable (Martes zibellina).

    PubMed

    Malyarchuk, Boris; Derenko, Miroslava; Denisova, Galina

    2014-10-15

    We assessed phylogeny of sable (Martes zibellina, Linnaeus, 1758) by sequence analysis of nearly complete, new mitochondrial genomes in 36 specimens from different localities in northern Eurasia (Primorye, Khabarovsk and Krasnoyarsk regions, the Kamchatka Peninsula, the Kuril Islands and the Urals). Phylogenetic analysis of mtDNA sequences demonstrates that two clades, A and BC, radiated about 200-300 thousandyears ago (kya) according to results of Bayesian molecular clock and RelTime analyses of different mitogenome alignments (nearly complete mtDNA sequences, protein-coding region, and synonymous sites), while the age estimates of clades A, B and C fall within the Late Pleistocene (~50-140 kya). Bayesian skyline plots (BSPs) of sable population size change based on analysis of nearly complete mtDNAs show an expansion around 40 kya in the warm Karganian time, without a decline of population size around the Last Glacial Maximum (21 kya). The BSPs based on synonymous clock rate indicate that M. zibellina experienced demographic expansions later, approximately 22 kya. The A2a clade that colonized Kamchatka ~23-50 kya (depending on the mutation rate used) survived the last glaciation there as demonstrated by the BSP analysis. In addition, we have found evidence of positive selection acting at ND4 and cytochrome b genes, thereby suggesting adaptive evolution of the A2a clade in Kamchatka.

  6. Jacaranda cuspidifolia Mart. (Bignoniaceae) as an antibacterial agent.

    PubMed

    Arruda, Ana Lúcia A; Vieira, Carla J B; Sousa, Daniella G; Oliveira, Regilene F; Castilho, Rachel O

    2011-12-01

    This study evaluated, in vitro, the antimicrobial activity of the hexane extract (JCHE), methanol extract (JCME), and chloroform fraction (JCCF) of bark from Jacaranda cuspidifolia Mart. (Family Bignoniaceae), a Brazilian medicinal plant, traditionally used as anti-syphilis and anti-gonorrhea treatment. The antimicrobial activity was evaluated using the disc diffusion method followed by the determination of minimum inhibitory concentration (MIC) values. JCHE was not active against the bacteria evaluated. JCME presented antibacterial activity against Streptococcus pyogenes, Staphylococcus aureus, and Neisseria gonorrhoeae with MIC values of 16.3 mg/mL, 9.1 mg/mL, and 25.2 mg/mL, respectively. JCCF was active against Staphylococcus epidermidis, S. aureus, Proteus mirabilis, Serratia marcescens, S. pyogenes, Enterobacter aerogenes, and N. gonorrhoeae with MIC values of 18.3 mg/mL, 9.3 mg/mL, 6.3 mg/mL, 6.1 mg/mL, 9.2 mg/mL, 6.2 mg/mL, and 25.2 mg/mL, respectively. Phytochemical analysis of JCME and JCCF gave positive results for saponins, coumarins, flavonoids, tannins, quinones, alkaloids, triterpenes, and steroids. Verbascoside was isolated and identified as a major peak in JCME and JCCF high-performance liquid chromatography fingerprints and might contribute to the observed antimicrobial activity.

  7. Antiproliferative activity of Luehea candicans Mart. et Zucc. (Tiliaceae).

    PubMed

    da Silva, Dioni A; Alves, Vanessa G; Franco, Danielle M M; Ribeiro, Laryssa C; de Souza, Maria C; Kato, Lucilia; de Carvalho, João E; Kohn, Luciana K; de Oliveira, Cecília M A; da Silva, Cleuza C

    2012-01-01

    Luehea candicans Mart. et Zucc. (Tiliaceae) is known as 'açoita-cavalo' and is one of the most important medicinal plants found in the Brazilian cerrado. The crude methanolic extracts of the branches and leaves and their fractions were evaluated using the following cancer cell lines: MCF-7 (breast), NCI-ADR (breast expressing the multidrug resistance phenotype), NCI-460 (lung), UACC-62 (melanoma), 786-0 (kidney), OVCAR (ovarian), PCO-3 (prostate), HT-29 (colon) and K-562 (leukaemia). The crude methanolic extracts from the branches (B) and leaves (L) were able to inhibit the growth of the K-562 and 786-0 cell lines in a dose-dependent manner, with GI(50) values of 8.1 and 5.4 µg mL(-1), respectively. The hexane (L1), chloroform (L2) and methanol (L4) fractions derived from extract L showed a high selectivity and pronounced cytostatic activity against 786-0 (GI(50) ~ 40 µg mL(-1)). A significant amount of lupeol was isolated from fraction L2. The chloroform (B2) and methanol (B3) fractions derived from extract (B) exhibited less selectivity, showing the highest cytostatic activity against K-562, NCI-ADR, OVCAR, MCF-7 and NCI-460 cells, with GI(50) values between 27 and 40 µg mL(-1). Lupeol, betulin, a mixture of steroids, (-)-epicatechin, vitexin and liriodendrin were isolated from these active fractions.

  8. Tiletamine-zolazepam-xylazine immobilization of American marten (Martes americana).

    PubMed

    Belant, Jerrold L

    2005-07-01

    The effectiveness of tiletamine-zolazepam (Telazol) and xylazine as an immobilizing combination for American martens (Martes americana) was evaluated. Fifteen martens were intramuscularly injected on 19 occasions using a 3:2 mixture of tiletamine-zolazepam (3.2+/-0.6 mg/kg [mean +/- SD]) and xylazine (2.1+/-0.4 mg/kg) at Pictured Rocks National Lakeshore, Michigan (USA) during May to October 2002-2003. Mean induction time was 2.5+/-1.8 min; mean recovery time was 70.8+/-31.9 min. There was no relation between the amount (mg/kg) of tiletamine-zolazepam-xylazine injected and induction (r(2)=0.08, P=0.26). However, there was an inverse relation (r(2)=0.28, P<0.01) between dosage and time to first effect of immobilants. Time to recovery increased (r(2)=0.21, P=0.05) with increased dosage. Mean heart rate, respiratory rate, and body temperature declined through 10 min postinduction (P<0.05). No mortality occurred and no short-term adverse effects were observed in recaptured individuals. In conclusion, a 3:2 mixture of tiletamine-zolazepam/xylazine is a safe and effective immobilizing agent for martens when conducting non-surgical field procedures. Immobilizing martens with 4.2 mg/kg tiletamine-zolazepam and 2.8 mg/kg xylazine should provide < or =30 min of handling time and allow full recovery in about 70 min.

  9. Rural maternity care: can we learn from Wal-Mart?

    PubMed

    van Teijlingen, E R; Pitchforth, E

    2010-03-01

    In many countries rural maternity care is under threat. Consequently rural pregnant women will have to travel further to attend larger maternity units to receive care and deliver their babies. This trend is not dissimilar from the disappearance of other rural services, such as village shops, banks, post offices and bus services. We use a comparative approach to draw an analogy with large-scale supermarkets, such as the Wal-Mart and Tesco and their effect on the viability of smaller rural shops, depersonalisation of service and the wider community. The closure of a community-maternity unit leads to women attending a different type of hospital with a different approach to maternity care. Thus small community-midwifery units are being replaced, not by a very similar unit that happens to be further away, but by a larger obstetric unit that operates on different models, philosophy and notions of risk. Comparative analysis allows a fresh perspective on the provision of rural maternity services. We argue that previous discussions focusing on medicalisation and change in maternity services can be enhanced by drawing on experience in other sectors and taking a wider societal lens.

  10. The socioeconomic context of the use of Euterpe precatoria Mart. and E. oleracea Mart. in Bolivia and Peru.

    PubMed

    Paniagua-Zambrana, Narel; Bussmann, Rainer W; Macía, Manuel J

    2017-06-02

    Traditional knowledge (TK) has enabled communities to adapt to changes in life conditions over centuries. However, this local context is being dramatically affected by recent changes through globalization and modernization of societies. In this paper we seek to identify socio-economic factors that are related to the knowledge and use of two palm species in mestizo and indigenous communities in the Amazonian of Peru and Bolivia. Both species are known in the region under the main vernacular name of Asaí, and are source of two highly commercialized resources: palm-hearts and fruits. Euterpe precatoria Mart. is native to the region whereas E. oleracea Mart. is being introduced for the use of both resources. We compare TK about the two Euterpe species in both countries in relation to 14 socioeconomic factors in seven use categories. We performed a Multivariate analysis of variance (MANOVA) to elucidate the influence of each socioeconomic factor on the overall palm knowledge or on individual use categories. In the two countries, we found that mestizos, speaking only Spanish, and migrants in the same ecoregion, knew more uses in all use categories for E. precatoria than for E. oleracea, even in use categories such as Medicinal and veterinary and Construction, for which indigenous participants had more uses in case of other species. In Peru, the use of E. precatoria was higher among participants with greater wealth, which could be related to the commercial importance that both the fruits and the palm-hearts have had in the markets of the region. In contrast, in Bolivia, although some income generation from Euterpe sp. was observed, the use of E. precatoria was much more homogeneously distributed. The use of E. oleracea in Bolivia is recent, and although its most important uses are related to the consumption of fruits and palm-hearts (Human food), it is now being slowly used for Medicinal and Construction purposes, similar to E. precatoria. The use of each of the species

  11. Seismic expression of Marts field (Silurian reef) in Sullivan County, Indiana

    SciTech Connect

    Renick, H.J. Jr.; Rene, R.M.; Hester, N.C.; Stanonis, F.L. )

    1989-08-01

    The Marts field of Sullivan County, Indiana, is associated with a Silurian reef that is part of the Terre Haute bank on the eastern flank of the Illinois basin. Gas production has come from Pennsylvanian sandstones at Marts field, and oil is presently being produced from limestones of the Devonian Muscatatuck Group. Hydrocarbons were trapped in the Devonian limestones because of structural drape over the reef. A 2.8-km (1.8-mi) north-south 24-CDP reflection seismic profile across the Marts field was obtained by using a hydraulic-assisted weight drop with a source array interval of 16.7 m (55 ft). The data were digitally processed through statics corrections, deconvolution, stack, and migration. These data clearly image drape in Carboniferous and Devonian strata, a characteristic change in reflection pattern at the reef flanks, and diffractions associated with the reef flanks. Near Marts field, one well penetrates Silurian strata, and a synthetic seismogram for this off-reef well is tied to the seismic section. Using well data from Marts and other reefs, mirror-imaged cross-plots of depths to tops of formations vs. depth to top of the Devonian limestone aid in examination of the drape. These plots of transformed cross sections approximate those of vertically stacked right circular cones indicative of the linear relationships between depths to formations.

  12. A mart-1::Cre transgenic line induces recombination in melanocytes and retinal pigment epithelium.

    PubMed

    Aydin, Iraz T; Beermann, Friedrich

    2011-05-01

    The number of transgenic mouse lines expressing Cre in either type of pigment cells (melanocytes and retinal pigment epithelium, RPE) is limited, and the available lines do not always offer sufficient specificity. In this study, we addressed this issue and we report on the generation of a MART-1::Cre BAC transgenic mouse line, in which the expression of Cre recombinase is controlled by regulatory elements of the pigment cell-specific gene MART-1 (mlana). When MART-1::Cre BAC transgenic mice were bred with the ROSA26-R reporter line, ß-galactosidase expression was observed in RPE from E12.5 onwards, and in melanocyte precursors from E17.5, indicating that the MART-1::Cre line provides Cre recombinase activity in pigment-producing cells rather than in a particular lineage. In addition, breeding of this mouse line to mice carrying a conditional allele of RBP-Jκ corroborated the reported phenotypes in both pigment cell lineages, inducing hair greying and microphthalmia. Our results thus suggest, that the MART-1::Cre line may serve as a novel and useful tool for functional studies in melanocytes and the RPE.genesis 49:403-409, 2011.

  13. Occurrence of internal parasites in stone martens (Martes foina) from Cracow and suburbs.

    PubMed

    Kornaś, Sławomir; Wierzbowska, Izabela A; Górski, Paweł; Okarma, Henryk

    2013-01-01

    The pine marten Martes martes and the stone marten Martes foina are the only representatives of the genus Martes in Poland. During the last few decades, an intensive synurbisation of stone martens has been recorded. The aim of the study was to assess the level of infection by internal parasites of Martes foina in the Cracow urban area. Eleven necropsies were performed of stone martens killed during animal-vehicle collisions. Additionally, coprological examination of 129 stone marten scats was included. For further analysis, two standard methods, i.e. flotation and decantation, were used. The intensity of infection by parasites was low. Taenia martis was found to be present in one marten individual by necropsy, while Taeniidae helminths and two genera of nematodes, Capillaria and Toxocara, were identified during coprodiagnosis. The diet analysis of stone marten scats revealed a high proportion of two food categories. Percentage frequency of occurrence for plant material and anthropogenic was calculated as 42.3% and 15.4%, respectively. This type of food composition might suggest lower infection by internal parasites in particular species, especially with an indirect life cycle.

  14. [Enhancing development of children at risk and their parents by video counselling according to the Marte Meo method].

    PubMed

    Bünder, Peter

    2011-01-01

    Marte Meo is a low-intensity programme of counselling parents and other persons significantly involved with children which aims to foster parenting capacity and facilitate child development. The article describes a preliminary pilot study with the aim of identifying variables for the future evaluation of efficacy and effectiveness of the Marte Meo method.

  15. Assessing performance of Bayesian state-space models fit to Argos satellite telemetry locations processed with Kalman filtering.

    PubMed

    Silva, Mónica A; Jonsen, Ian; Russell, Deborah J F; Prieto, Rui; Thompson, Dave; Baumgartner, Mark F

    2014-01-01

    Argos recently implemented a new algorithm to calculate locations of satellite-tracked animals that uses a Kalman filter (KF). The KF algorithm is reported to increase the number and accuracy of estimated positions over the traditional Least Squares (LS) algorithm, with potential advantages to the application of state-space methods to model animal movement data. We tested the performance of two Bayesian state-space models (SSMs) fitted to satellite tracking data processed with KF algorithm. Tracks from 7 harbour seals (Phoca vitulina) tagged with ARGOS satellite transmitters equipped with Fastloc GPS loggers were used to calculate the error of locations estimated from SSMs fitted to KF and LS data, by comparing those to "true" GPS locations. Data on 6 fin whales (Balaenoptera physalus) were used to investigate consistency in movement parameters, location and behavioural states estimated by switching state-space models (SSSM) fitted to data derived from KF and LS methods. The model fit to KF locations improved the accuracy of seal trips by 27% over the LS model. 82% of locations predicted from the KF model and 73% of locations from the LS model were <5 km from the corresponding interpolated GPS position. Uncertainty in KF model estimates (5.6 ± 5.6 km) was nearly half that of LS estimates (11.6 ± 8.4 km). Accuracy of KF and LS modelled locations was sensitive to precision but not to observation frequency or temporal resolution of raw Argos data. On average, 88% of whale locations estimated by KF models fell within the 95% probability ellipse of paired locations from LS models. Precision of KF locations for whales was generally higher. Whales' behavioural mode inferred by KF models matched the classification from LS models in 94% of the cases. State-space models fit to KF data can improve spatial accuracy of location estimates over LS models and produce equally reliable behavioural estimates.

  16. Observation of the TeV Gamma-Ray Source MGRO J1908+06 with ARGO-YBJ

    NASA Astrophysics Data System (ADS)

    Bartoli, B.; Bernardini, P.; Bi, X. J.; Bleve, C.; Bolognino, I.; Branchini, P.; Budano, A.; Calabrese Melcarne, A. K.; Camarri, P.; Cao, Z.; Cardarelli, R.; Catalanotti, S.; Cattaneo, C.; Chen, S. Z.; Chen, T. L.; Chen, Y.; Creti, P.; Cui, S. W.; Dai, B. Z.; D'Alí Staiti, G.; Danzengluobu; Dattoli, M.; De Mitri, I.; D'Ettorre Piazzoli, B.; Di Girolamo, T.; Ding, X. H.; Di Sciascio, G.; Feng, C. F.; Feng, Zhaoyang; Feng, Zhenyong; Galeazzi, F.; Giroletti, E.; Gou, Q. B.; Guo, Y. Q.; He, H. H.; Hu, Haibing; Hu, Hongbo; Huang, Q.; Iacovacci, M.; Iuppa, R.; James, I.; Jia, H. Y.; Labaciren; Li, H. J.; Li, J. Y.; Li, X. X.; Liguori, G.; Liu, C.; Liu, C. Q.; Liu, J.; Liu, M. Y.; Lu, H.; Ma, X. H.; Mancarella, G.; Mari, S. M.; Marsella, G.; Martello, D.; Mastroianni, S.; Montini, P.; Ning, C. C.; Pagliaro, A.; Panareo, M.; Panico, B.; Perrone, L.; Pistilli, P.; Qu, X. B.; Ruggieri, F.; Salvini, P.; Santonico, R.; Shen, P. R.; Sheng, X. D.; Shi, F.; Stanescu, C.; Surdo, A.; Tan, Y. H.; Vallania, P.; Vernetto, S.; Vigorito, C.; Wang, B.; Wang, H.; Wu, C. Y.; Wu, H. R.; Xu, B.; Xue, L.; Yan, Y. X.; Yang, Q. Y.; Yang, X. C.; Yao, Z. G.; Yuan, A. F.; Zha, M.; Zhang, H. M.; Zhang, Jilong; Zhang, Jianli; Zhang, L.; Zhang, P.; Zhang, X. Y.; Zhang, Y.; Zhaxiciren; Zhaxisangzhu; Zhou, X. X.; Zhu, F. R.; Zhu, Q. Q.; Zizzi, G.; Argo-YBJ Collaboration

    2012-12-01

    The extended gamma-ray source MGRO J1908+06, discovered by the Milagro air shower detector in 2007, has been observed for ~4 years by the ARGO-YBJ experiment at TeV energies, with a statistical significance of 6.2 standard deviations. The peak of the signal is found at a position consistent with the pulsar PSR J1907+0602. Parameterizing the source shape with a two-dimensional Gauss function, we estimate an extension of σext = 0fdg49 ± 0fdg22, which is consistent with a previous measurement by the Cherenkov Array H.E.S.S. The observed energy spectrum is dN/dE = 6.1 ± 1.4 × 10-13 (E/4 TeV)-2.54 ± 0.36 photons cm-2 s-1 TeV-1, in the energy range of ~1-20 TeV. The measured gamma-ray flux is consistent with the results of the Milagro detector, but is ~2-3 times larger than the flux previously derived by H.E.S.S. at energies of a few TeV. The continuity of the Milagro and ARGO-YBJ observations and the stable excess rate observed by ARGO-YBJ and recorded in four years of data support the identification of MGRO J1908+06 as the steady powerful TeV pulsar wind nebula of PSR J1907+0602, with an integrated luminosity over 1 TeV ~ 1.8 times the luminosity of the Crab Nebula.

  17. Assessing Performance of Bayesian State-Space Models Fit to Argos Satellite Telemetry Locations Processed with Kalman Filtering

    PubMed Central

    Silva, Mónica A.; Jonsen, Ian; Russell, Deborah J. F.; Prieto, Rui; Thompson, Dave; Baumgartner, Mark F.

    2014-01-01

    Argos recently implemented a new algorithm to calculate locations of satellite-tracked animals that uses a Kalman filter (KF). The KF algorithm is reported to increase the number and accuracy of estimated positions over the traditional Least Squares (LS) algorithm, with potential advantages to the application of state-space methods to model animal movement data. We tested the performance of two Bayesian state-space models (SSMs) fitted to satellite tracking data processed with KF algorithm. Tracks from 7 harbour seals (Phoca vitulina) tagged with ARGOS satellite transmitters equipped with Fastloc GPS loggers were used to calculate the error of locations estimated from SSMs fitted to KF and LS data, by comparing those to “true” GPS locations. Data on 6 fin whales (Balaenoptera physalus) were used to investigate consistency in movement parameters, location and behavioural states estimated by switching state-space models (SSSM) fitted to data derived from KF and LS methods. The model fit to KF locations improved the accuracy of seal trips by 27% over the LS model. 82% of locations predicted from the KF model and 73% of locations from the LS model were <5 km from the corresponding interpolated GPS position. Uncertainty in KF model estimates (5.6±5.6 km) was nearly half that of LS estimates (11.6±8.4 km). Accuracy of KF and LS modelled locations was sensitive to precision but not to observation frequency or temporal resolution of raw Argos data. On average, 88% of whale locations estimated by KF models fell within the 95% probability ellipse of paired locations from LS models. Precision of KF locations for whales was generally higher. Whales’ behavioural mode inferred by KF models matched the classification from LS models in 94% of the cases. State-space models fit to KF data can improve spatial accuracy of location estimates over LS models and produce equally reliable behavioural estimates. PMID:24651252

  18. Text data extraction for a prospective, research-focused data mart: implementation and validation

    PubMed Central

    2012-01-01

    Background Translational research typically requires data abstracted from medical records as well as data collected specifically for research. Unfortunately, many data within electronic health records are represented as text that is not amenable to aggregation for analyses. We present a scalable open source SQL Server Integration Services package, called Regextractor, for including regular expression parsers into a classic extract, transform, and load workflow. We have used Regextractor to abstract discrete data from textual reports from a number of ‘machine generated’ sources. To validate this package, we created a pulmonary function test data mart and analyzed the quality of the data mart versus manual chart review. Methods Eleven variables from pulmonary function tests performed closest to the initial clinical evaluation date were studied for 100 randomly selected subjects with scleroderma. One research assistant manually reviewed, abstracted, and entered relevant data into a database. Correlation with data obtained from the automated pulmonary function test data mart within the Northwestern Medical Enterprise Data Warehouse was determined. Results There was a near perfect (99.5%) agreement between results generated from the Regextractor package and those obtained via manual chart abstraction. The pulmonary function test data mart has been used subsequently to monitor disease progression of patients in the Northwestern Scleroderma Registry. In addition to the pulmonary function test example presented in this manuscript, the Regextractor package has been used to create cardiac catheterization and echocardiography data marts. The Regextractor package was released as open source software in October 2009 and has been downloaded 552 times as of 6/1/2012. Conclusions Collaboration between clinical researchers and biomedical informatics experts enabled the development and validation of a tool (Regextractor) to parse, abstract and assemble structured data from text

  19. ARGO data assimilation into the ocean dynamics model with high spatial resolution using Ensemble Optimal Interpolation (EnOI)

    NASA Astrophysics Data System (ADS)

    Kaurkin, M. N.; Ibrayev, R. A.; Belyaev, K. P.

    2016-11-01

    The article proposes parallel implementation of the Ensemble Optimal Interpolation (EnOI) data assimilation (DA) method in eddy-resolving World Ocean circulation model. The results of DA experiments in North Atlantic with ARGO drifters are compared with the multivariate optimal interpolation (MVOI) DA scheme. The sensitivity of the model error, i.e., the difference between the model and observations depending on the number of ensemble elements, is also assessed and presented. The effectiveness of this method over the MVOI scheme is confirmed. The model outputs with and without assimilation are also compared with independent sea surface temperature data from ARMOR 3d.

  20. Sea-floor observations in the tongue of the ocean, Bahamas: An Argo/SeaMARC survey

    USGS Publications Warehouse

    Schwab, W.C.; Uchupi, E.; Ballard, Richard D.; Dettweiler, T.K.

    1989-01-01

    SeaMARC side-scan sonographs and Argo video and photographic data suggest that the recent sedimentary environment of the floor of the Tongue of the Ocean is controlled by an interplay of turbidity current flow from the south, sediment spill-over from the carbonate platform to the east (windward side), and rock falls from the west carbonate escarpment (lee side). The spill-over forms a sandy sedimentary deposit that acts as a topographic obstruction to the turbidity current flow from the south. This obstruction is expressed by the westward migration of a northwest-southeast oriented turbidity-current-cut channel. ?? 1989 Springer-Verlag New York Inc.

  1. Near-Real Time Monthly Global Temperature and Salinity Gridded Data from New Ocean Exploration by Argo Floats

    NASA Astrophysics Data System (ADS)

    Chu, P. C.; Sun, L.; Fan, C.

    2010-12-01

    New ocean exploration by Argo floats provides sufficient spatial and temporal coverage for sampling the global ocean temperature and salinity. Currently, there are 3193 Argo floats all over the world oceans. Combined with traditionally sampled data, they are included into the Global Temperature and Salinity Profile Program (GTSPP). To fully understanding the variability in ocean thermohaline structure and then its effects on climate variability needs a sufficient resolution in space and, especially, in time, gridded ocean temperature and salinity (T, S) dataset. We analyzed observational profiles (from Argo and traditional technologies) from the GTSPP and produced a T-S data set to meet the above need. GTSPP is a joint programme of the International Oceanographic Data and Information Exchange committee (IODE) and the Joint Commission on Oceanography and Marine Meteorology (JCOMM). IODE and JCOMM are technical committees of the Intergovernmental Oceanographic Commission and the World Meteorological Organization. The quality control procedures used in GTSPP were developed by the Marine Environmental Data Service (MEDS), now the Integrated Science Data Management (ISDM), of Canada. The GTSPP handles all temperature and salinity profile data. This includes observations collected using water samplers, continuous profiling instruments such as Argo, CTDs, thermistor chain data and observations acquired using thermosalinographs. These data will reach data processing centres of the Program through the real-time channels of the IGOSS program or in delayed mode through the IODE system. Real-time data in GTSPP are acquired from the Global Telecommunications System in the bathythermal (BATHY) and temperature, salinity & current (TESAC) codes forms supported by the WMO. Delayed mode data are contributed directly by member states of IOC. Any variable (temperature, salinity, or velocity) can be decomposed into generalized Fourier series using the recently developed optimal

  2. [Effect of constitutive expression of ARGOS-LIKE gene on dimensions of cells and organs of transgenic tobacco plants].

    PubMed

    Kuluev, B R; Khiazev, A V; Safiullina, M G; Cemeris, A V

    2013-05-01

    Transgenic tobacco plants that overexpress the ARGOS-LIKE (ARL) gene of Arabidopsis thaliana have been developed. The transgenic plants possessed increased dimensions of leaves and stem, whereas the magnitude of flowers was modified to a lesser degree. The increase in the organ dimensions was a result of stimulation of cell expansion; the cell quantity in the organ was even decreased. Ectopic expression of the ARL gene was promoted in order to increase in the level of mRNA of tobacco expansine NtEXPA5. It has been shown that the ARL gene of A. thaliana can be used to obtain transgenic plants with increased sizes of the leaves and stem.

  3. BIO ARGO floats: tools for operational monitoring of the Black Sea

    NASA Astrophysics Data System (ADS)

    Palazov, Atanas; Slabakova, Violeta; Peneva, Elisaveta; Stanev, Emil

    2014-05-01

    The assessment of ecological status in the context of the Water Framework Directive (WFD) and Marine Strategy Framework Directive (MSFD) requires comprehensive knowledge and understanding of the physical and biogeochemical processes that determine the functioning of marine ecosystems. One of the main challenges however is the need of data with frequency relevant to the spatial and temporal scales of the ecological processes. The majority of in situ observations that are commonly used for ecological monitoring of the Black Sea are generally based on near-shore monitoring programs or irregular oceanographic cruises that provide either non-synoptic, coarse resolution realizations of large scale processes or detailed, but time and site specific snapshots of local features. These gaps can be filled by two independent sources: satellite observation and profiling floats. In fact satellite ocean color sensors allows for determination at synoptic scale of water quality parameters through its absorption properties. However the satellite ocean color methods have a number of limitations such as: measurements can only be made during daylight hours; require cloud-free conditions and are sensitive to atmospheric aerosols; provide information only for the upper layer of the ocean (approximately the depth of 10% incident light); algorithms developed for global applications are a source of large uncertainties in the marginal seas and costal areas. These constrains of the optical remote sensing observations can be avoided by using miniature biogeochemical sensors and autonomous platforms that offer remarkable perspectives for observing the "biological" ocean, notably at critical spatiotemporal scales which have been out of reach until recently (Claustre et al., 2010). In the frame of "E-AIMS: Euro-Argo Improvements for the GMES marine Service" 7 EC FP project two Bio Argo floats were deployed in the Black Sea. Beside the traditionally CTD the floats were equipped with biogeochemical

  4. [Manuel Martínez Baez: a very personal opinion on tropical diseases].

    PubMed

    Rodríguez de Romo, A C

    1993-01-01

    The work of doctor Manuel Martínez Baéz (1894-1987) is very vast and it is clearly related to three different areas of medicine: parasitology, public health and medical sociology, and history of medicine. This work studies an aspect of his ideology concerning public health and social medicine which is related to tropical diseases. The contribution of Martínez Báez to this area was important because he adapted to the reality of underdeveloped countries concepts concerning tropical diseases originated in countries foreign to this problem.

  5. Ketamine and midazolam anesthesia in Pacific martens (Martes caurina).

    PubMed

    Mortenson, Jack A; Moriarty, Katie M

    2015-01-01

    Abstract The use of midazolam as a tranquilizer for anesthesia in mustelids in conjunction with the cyclohexamine ketamine is not well documented. Because midazolam is fast acting, inexpensive, and quickly metabolized, it may serve as a good alternative to other more commonly used tranquilizers. We trapped and anesthetized 27 Pacific martens (Martes caurina) in Lassen National Forest (northern California, US) August 2010-April 2013. We assessed anesthesia with ketamine at 18 and 25 mg/kg combined with 0.2 mg/kg of midazolam by comparing mean times of induction, return to consciousness, and recovery, plus physiologic parameters. No reversal was used for the midazolam portion of the anesthetic. Mean (±SD) induction for both ketamine dosages was 1.7±0.5 and 1.8±1.0 min, respectively. Return to consciousness mean times were 8.0 min longer (P<0.001) for martens receiving a 25 mg/kg ketamine dosage. Mean recoveries were 15.1 min longer (P<0.003) for the 25 mg/kg ketamine dosage. Physiologic parameter means were similar for both ketamine dosages with no statistically significant differences. Body temperatures and heart and respiratory rates were generally stable, but percentage of oxygen saturation and end tidal carbon dioxide values were below those seen in previous mustelid studies. The combination of ketamine, at both dosages, and midazolam provided reliable field anesthesia for Pacific martens, and supplemental oxygen is recommended as needed.

  6. Using Argo Floats to Characterize Sea Ice-Ocean Dynamics in the Weddell Sea

    NASA Astrophysics Data System (ADS)

    Lindeman, M. R.; Boebel, O.; Kanzow, T.

    2016-12-01

    Argo floats in the Weddell Sea are equipped with ice-avoidance algorithms, allowing them to record temperature and salinity year-round and revealing previously unobservable ocean dynamics driven by sea ice formation and melt. This study takes a Lagrangian approach to float data collected from 2008-2012 to examine patterns of spatiotemporal variability in seasonal evolution of the sea ice cover and upper ocean hydrography. Warm Circumpolar Deep Water (CDW) flows into the cyclonic Weddell Gyre east of the prime meridian, resulting in a steep thermocline and relatively strong stratification. As a water parcel moves westward along the poleward limb of the gyre, the erosion of core CDW characteristics between 100-300m results in gradual weakening of stratification and deepening of the winter mixed layer, up to about 100m. Annual changes in the salinity budget indicate preferential sea ice formation and export in this region, poleward of approximately 67ºS, with over 150cm of ice forming between March and November in parts of the gyre interior. North of this latitude, the winter mixed layer is deeper (150-200m) and weaker stratification promotes entrainment of warm deep water, contributing to high net volume and rapid rate of sea ice melt, as well as delayed onset of freezing in fall/winter. In addition to its regional significance, the role of sea ice as a driver of Weddell Sea hydrography has important climatic implications, notably as it relates to the export of dense Weddell Sea bottom water present throughout the global ocean.

  7. Mesoscale variability of water masses in the Arabian Sea as revealed by ARGO floats

    NASA Astrophysics Data System (ADS)

    Carton, X.; L'Hegaret, P.

    2011-06-01

    By analysing ARGO float data over the last four years, some aspects of the mesoscale variability of water masses in the Arabian Sea are described. The Red Sea Water outflow is strong in the Southwestern Gulf of Aden, in particular when a cyclonic gyre predominates in this region. Salinities of 36.5 and temperatures of 16 °C are found there between 600 and 1000 m depths. The Red Sea Water is more dilute in the eastern part of the Gulf, and fragments of this water mass can be advected offshore across the gulf or towards its northern coast by the regional gyres. The Red Sea Water outflow is also detected along the northeastern coast of Socotra, and fragments of RSW are found between one and three degrees of latitude north of this island. In the whole Gulf of Aden, the correlation between the deep motions of the floats and the SSH measured by altimetry is strong, at regional scale. The finer scale details of the float trajectories are more often related to the anomalous water masses that they encounter. The Persian Gulf Water (PGW) is found in the float profiles near Ras ash Sharbatat (near 57° E, 18° N), again with 36.5 in salinity and about 18-19 °C in temperature. These observations were achieved in winter when the southwestward monsoon currents can advect PGW along the South Arabian coast. Fragments of PGW are found in the Arabian Sea between 18 and 20° N and 63 and 65° E, showing that this water mass can escape the Gulf of Oman southeastward, in particular during summer.

  8. Observation of the cosmic ray moon shadowing effect with the ARGO-YBJ experiment

    NASA Astrophysics Data System (ADS)

    Bartoli, B.; Bernardini, P.; Bi, X. J.; Bleve, C.; Bolognino, I.; Branchini, P.; Budano, A.; Calabrese Melcarne, A. K.; Camarri, P.; Cao, Z.; Cardarelli, R.; Catalanotti, S.; Cattaneo, C.; Celio, P.; Chen, S. Z.; Chen, T. L.; Chen, Y.; Creti, P.; Cui, S. W.; Dai, B. Z.; D'Alí Staiti, G.; Danzengluobu; Dattoli, M.; de Mitri, I.; D'Ettorre Piazzoli, B.; di Girolamo, T.; Ding, X. H.; di Sciascio, G.; Feng, C. F.; Feng, Zhaoyang; Feng, Zhenyong; Galeazzi, F.; Giroletti, E.; Gou, Q. B.; Guo, Y. Q.; He, H. H.; Hu, Haibing; Hu, Hongbo; Huang, Q.; Iacovacci, M.; Iuppa, R.; James, I.; Jia, H. Y.; Labaciren; Li, H. J.; Li, J. Y.; Li, X. X.; Liguori, G.; Liu, C.; Liu, C. Q.; Liu, J.; Liu, M. Y.; Lu, H.; Ma, X. H.; Mancarella, G.; Mari, S. M.; Marsella, G.; Martello, D.; Mastroianni, S.; Montini, P.; Ning, C. C.; Pagliaro, A.; Panareo, M.; Panico, B.; Perrone, L.; Pistilli, P.; Qu, X. B.; Rossi, E.; Ruggieri, F.; Salvini, P.; Santonico, R.; Shen, P. R.; Sheng, X. D.; Shi, F.; Stanescu, C.; Surdo, A.; Tan, Y. H.; Vallania, P.; Vernetto, S.; Vigorito, C.; Wang, B.; Wang, H.; Wu, C. Y.; Wu, H. R.; Xu, B.; Xue, L.; Yan, Y. X.; Yang, Q. Y.; Yang, X. C.; Yao, Z. G.; Yuan, A. F.; Zha, M.; Zhang, H. M.; Zhang, Jilong; Zhang, Jianli; Zhang, L.; Zhang, P.; Zhang, X. Y.; Zhang, Y.; Zhaxiciren; Zhaxisangzhu; Zhou, X. X.; Zhu, F. R.; Zhu, Q. Q.; Zizzi, G.

    2011-07-01

    Cosmic rays are hampered by the Moon and a deficit in its direction is expected (the so-called Moon shadow). The Moon shadow is an important tool to determine the performance of an air shower array. Indeed, the westward displacement of the shadow center, due to the bending effect of the geomagnetic field on the propagation of cosmic rays, allows the setting of the absolute rigidity scale of the primary particles inducing the showers recorded by the detector. In addition, the shape of the shadow permits to determine the detector point spread function, while the position of the deficit at high energies allows the evaluation of its absolute pointing accuracy. In this paper we present the observation of the cosmic ray Moon shadowing effect carried out by the ARGO-YBJ experiment in the multi-TeV energy region with high statistical significance (55 standard deviations). By means of an accurate Monte Carlo simulation of the cosmic rays propagation in the Earth-Moon system, we have studied separately the effect of the geomagnetic field and of the detector point spread function on the observed shadow. The angular resolution as a function of the particle multiplicity and the pointing accuracy have been obtained. The primary energy of detected showers has been estimated by measuring the westward displacement as a function of the particle multiplicity, thus calibrating the relation between shower size and cosmic ray energy. The stability of the detector on a monthly basis has been checked by monitoring the position and the deficit of the Moon shadow. Finally, we have studied with high statistical accuracy the shadowing effect in the day/”night” time looking for possible effect induced by the solar wind.

  9. Water intrusions and particle signatures in the Black Sea: a Biogeochemical-Argo float investigation

    NASA Astrophysics Data System (ADS)

    Stanev, Emil Vassilev; Grayek, Sebastian; Claustre, Hervé; Schmechtig, Chaterine; Poteau, Antoine

    2017-07-01

    Continuous observations during 3 years with a vertical resolution of 1 dbar from two Bio-Argo floats in the Black Sea that were equipped with oxygen optodes, chlorophyll fluorometers, and backscattering sensors are analyzed. The particle backscattering coefficient, b bp provides a proxy for the concentration of suspended particles. The observations clearly identify thermal and b bp intrusions down to 700-800 m in the Bosporus inflow area. In this area, b bp is more than five times larger than elsewhere, which could indicate bacterial abundance and possible biological involvement in the precipitation of Mn-containing particles. The b bp anomalies become much shallower than the temperature anomalies with increasing distance to the east of the strait. Their maxima are located between the onset of the suboxic zone and the upper part of the anoxic layer. Unlike well-known intrusions that are caused by inflow, open ocean intrusions are shallower and often characterized by multiple layers of backscatter maxima with thicknesses of only 15-20 m. The ratio between backscattering coefficients measured at two wavelengths, which gives a proxy for particle size, shows that the relative amount of larger size particles in the anoxic layer increases with depth. The particle concentrations and their size distribution display different vertical variability, which indicates the complex transformation of biological matter. The lower concentration of particles and lower chlorophyll-a during the extremely warm 2016 reveals an overall positive correlation between the two properties. The trends in the particle backscattering coefficient in the suboxic zone during 2013-2016 could indirectly reveal a biogeochemical response to temperature changes.

  10. Water intrusions and particle signatures in the Black Sea: a Biogeochemical-Argo float investigation

    NASA Astrophysics Data System (ADS)

    Stanev, Emil Vassilev; Grayek, Sebastian; Claustre, Hervé; Schmechtig, Chaterine; Poteau, Antoine

    2017-09-01

    Continuous observations during 3 years with a vertical resolution of 1 dbar from two Bio-Argo floats in the Black Sea that were equipped with oxygen optodes, chlorophyll fluorometers, and backscattering sensors are analyzed. The particle backscattering coefficient, b bp provides a proxy for the concentration of suspended particles. The observations clearly identify thermal and b bp intrusions down to 700-800 m in the Bosporus inflow area. In this area, b bp is more than five times larger than elsewhere, which could indicate bacterial abundance and possible biological involvement in the precipitation of Mn-containing particles. The b bp anomalies become much shallower than the temperature anomalies with increasing distance to the east of the strait. Their maxima are located between the onset of the suboxic zone and the upper part of the anoxic layer. Unlike well-known intrusions that are caused by inflow, open ocean intrusions are shallower and often characterized by multiple layers of backscatter maxima with thicknesses of only 15-20 m. The ratio between backscattering coefficients measured at two wavelengths, which gives a proxy for particle size, shows that the relative amount of larger size particles in the anoxic layer increases with depth. The particle concentrations and their size distribution display different vertical variability, which indicates the complex transformation of biological matter. The lower concentration of particles and lower chlorophyll-a during the extremely warm 2016 reveals an overall positive correlation between the two properties. The trends in the particle backscattering coefficient in the suboxic zone during 2013-2016 could indirectly reveal a biogeochemical response to temperature changes.

  11. Argo profiles nonlinear feedback processes associated with the Indian Ocean Dipole

    NASA Astrophysics Data System (ADS)

    Cai, W.; Qiu, Y.

    2012-12-01

    A well-known feature of the Indian Ocean Dipole (IOD) is its positive skewness, with cold sea surface temperature (SST) anomalies over the east pole (IODE) exhibiting a larger amplitude than warm SST anomalies. Several mechanisms have been proposed for this asymmetry, but due to a lack of observations, the role of various processes remains contentious. Using Argo profiles and other newly available data, we provide an observation-based assessment of the IOD skewness. Firstly, the role of a nonlinear dynamical heating process is re-affirmed, which reinforces IODE cold anomalies but damps IODE warm anomalies. This reinforcing effect is greater than the damping effect, further contributing to the skewness. Secondly, the existence of a thermocline-temperature feedback asymmetry, whereby IODE cold anomalies induced by a shoaling thermocline are greater than warm anomalies associated with a deepening thermocline, is the primary forcing of the IOD skewness. This thermocline-temperature feedback asymmetry is a part of the nonlinear Bjerknes-like positive feedback loop involving winds, SST, and the thermocline, all displaying a consistent asymmetry with a stronger response when IODE SST anomalies are anomalously cool. The asymmetry is enhanced by a nonlinear barrier layer response, showing a greater thinning associated with IODE cold anomalies than a thickening associated with IODE warm anomalies. Finally, in response to IODE cool anomalies, rainfall and evaporative heat loss reduce, and incoming shortwave radiation increases, damping the SST anomalies. The damping increases with IODE cold anomalies. Thus, the IOD skewness is generated in spite of a greater damping effect of the SST-cloud-radiation feedback process.

  12. Argo: The Next Step in the Exploration of the Outer Solar System

    NASA Astrophysics Data System (ADS)

    Hansen, Candice; ARGO Science Team

    2009-09-01

    Revolutionary new ideas about the evolution of the outer solar system and its coupling with the primordial and present-day Kuiper Belt suggest that Neptune may have formed much closer to the sun than its current position. This new perspective and the fact that nearly all aspects of the Neptune system that we can measure from Earth have changed dramatically since Voyager, including Neptune's atmosphere, its ring system, and the atmosphere of its large moon Triton, demands a new examination of Neptune. A spacecraft equipped with modern technology, on a flyby trajectory past Neptune, will yield significant new ice-giant-system science. A Neptune flyby also provides a critical advantage over a Neptune orbiter: it offers the opportunity to explore a scientifically-selected Kuiper Belt Object (KBO) because of the trajectory's large bending angle due to massive Neptune. This allows access to a vast cone of space, yielding numerous potential targets among the known KBO population. Observations of KBOs have illuminated the formation and early evolution of the solar system. The compositional make-up and chemical evolution of KBOs provide clues of the earliest conditions in critical regions of the solar nebula, and the current distributions of astrobiologically and cosmochemically important materials. Argo is an innovative mission concept for New Frontiers 4: it flies by Triton and Neptune, and continues on to explore a Kuiper Belt Object. A launch opportunity is open from 2015 through 2019. It allows trajectories with reasonably short trip times to Neptune (8-11 years) and the Kuiper Belt (an additional 3-5 years), as well as low Triton approach speeds. We envision a New Frontiers mission employing current spacecraft technology with a simple yet capable payload. This work was partially supported by the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration

  13. TeV gamma-ray survey of the northern sky using the ARGO-YBJ detector

    SciTech Connect

    Bartoli, B.; Catalanotti, S.; Bernardini, P.; D'Amone, A.; De Mitri, I.; Bi, X. J.; Cao, Z.; Chen, S. Z.; Chen, Y.; Bolognino, I.; Branchini, P.; Budano, A.; Calabrese Melcarne, A. K.; Cardarelli, R.; Chen, T. L.; Danzengluobu; Creti, P.; Cui, S. W.; Dai, B. Z.; Collaboration: ARGO-YBJ Collaboration; and others

    2013-12-10

    The Astrophysical Radiation with Ground-based Observatory at Yang Ba Jing (ARGO-YBJ) detector is an extensive air shower array that has been used to monitor the northern γ-ray sky at energies above 0.3 TeV from 2007 November to 2013 January. In this paper, we present the results of a sky survey in the declination band from –10° to 70°, using data recorded over the past five years. With an integrated sensitivity ranging from 0.24 to ∼1 Crab units depending on the declination, six sources have been detected with a statistical significance greater than five standard deviations. Several excesses are also reported as potential γ-ray emitters. The features of each source are presented and discussed. Additionally, 95% confidence level upper limits of the flux from the investigated sky region are shown. Specific upper limits for 663 GeV γ-ray active galactic nuclei inside the ARGO-YBJ field of view are reported. The effect of the absorption of γ-rays due to the interaction with extragalactic background light is estimated.

  14. Study of the long time-scale variability of cosmic rays with the ARGO-YBJ experiment

    NASA Astrophysics Data System (ADS)

    Cappa, Alba; James, Irina; Salvini, Paola

    The long term modulation of the cosmic ray intensity includes both Sun and celestial anisotropies. The solar activity is due to high energy flares producing a decrease (known as Forbush Decrease, FD) in the cosmic ray intensity, with a time scale of the order of a few days, often accompained by a Ground Level Enhancement, due to direct Sun emission during the solar flare. The celestial anisotropies are due to the Earth motion in the cosmic rays reference system (solar anisotropy: Compton-Getting effect) and to the solar system location inside the Galaxy (sidereal anisotropies). These anisotropies are studied in ground-base experiments by means of EAS arrays, and the high energy solar emission is mainly studied from ground by neutron monitors. In the ARGO-YBJ experiment these phenomena are investigated by means of the "scaler mode" technique: the detector counting rates of four low multiplicity channels from singles to four-fold coincidences are recorded in a fixed time window of 0.5 s. The signal corresponds to a significant enhancement of the observed counting rate, after correcting the data for enviromental and instrumental parameters. In this paper we present the sensitivity of the ARGO-YBJ detector and the first results for both solar physics and cosmic ray anisotropy studies.

  15. A needlet-based approach to the shower-mode data analysis in the ARGO-YBJ experiment

    NASA Astrophysics Data System (ADS)

    Iuppa, R.; Di Sciascio, G.; Hansen, F. K.; Marinucci, D.; Santonico, R.; ARGO-YBJ Collaboration

    2012-11-01

    The ARGO-YBJ experiment, located at the Yangbajing Cosmic Ray Laboratory (Tibet, 4300 m a.s.l., 606 g/cm2), is an EAS-array exploiting the full coverage approach at high altitude. The large field of view (2 sr) and the low energy threshold (few hundreds of GeV) result in a trigger rate of ∼3.5 kHz and ∼1011 EAS collected per year. Such a data set contains signals laying on different angular scales: point-like and extended gamma-ray sources, as well as large and intermediate scale cosmic-ray anisotropies. The separation of all these contributions is crucial, mostly when they overlap with each other. Needlets are a new form of spherical wavelets that have recently drawn a lot of attention in the cosmological literature, especially in connection with the analysis of CMB data. Needlets enjoy a number of important statistical and numerical properties which suggest that they can be very effective in handling cosmic-ray and gamma-ray data analysis. An unprecedented application to astroparticle physics is shown here. In particular, we focus on their use for background estimation, which is expected to be optimal or nearly-optimal in a well-defined mathematical sense, and for point-source detection. This technique is applied here to the ARGO-YBJ data set, stressing its advantages with respect to standard methods.

  16. (abstract) ARGOS: a System to Monitor Ulysses Nutation and Thruster Firings from Variations of the Spacecraft Radio Signal

    NASA Technical Reports Server (NTRS)

    McElrath, T. P.; Cangahuala, L. A.; Miller, K. J.; Stravert, L. R.; Garcia-Perez, Raul

    1995-01-01

    Ulysses is a spin-stabilized spacecraft that experienced significant nutation after its launch in October 1990. This was due to the Sun-spacecraft-Earth geometry, and a study of the phenomenon predicted that the nutation would again be a problem during 1994-95. The difficulty of obtaining nutation estimates in real time from the spacecraft telemetry forced the ESA/NASA Ulysses Team to explore alternative information sources. The work performed by the ESA Operations Team provided a model for a system that uses the radio signal strength measurements to monitor the spacecraft dynamics. These measurements (referred to as AGC) are provided once per second by the tracking stations of the DSN. The system was named ARGOS (Attitude Reckoning from Ground Observable Signals) after the ever-vigilant, hundred-eyed giant of Greek Mythology. The ARGOS design also included Doppler processing, because Doppler shifts indicate thruster firings commanded by the active nutation control carried out onboard the spacecraft. While there is some visibility into thruster activity from telemetry, careful processing of the high-sample-rate Doppler data provides an accurate means of detecting the presence and time of thruster firings. DSN Doppler measurements are available at a ten-per-second rate in the same tracking data block as the AGC data.

  17. Spreading of Polar Water Masses into the Nordic Seas - Analyses of hydrographic measurements from Seagliders and Argo floats

    NASA Astrophysics Data System (ADS)

    Latarius, K.

    2016-02-01

    Hydrographic measurements from Seagliders and Argo-floats were analyzed with regard to the variation of freshwater in the western Nordic Seas. Fresh polar water masses and sea ice leave the Arctic Ocean through Fram Strait with the East Greenland Current. But it is still not clear how much of this water continues across the Greenland-Scotland-Ridge into the subpolar North Atlantic versus leakages into the deep western basins of the Nordic Seas. The amount of liquid freshwater is additionally rising on the way through the Nordic Seas due to ice melt. If it reaches the western basins (Greenland Sea Basin and Icelandic Plateau) the convection during winter will be damped by a surface layer of extremely light waters. This may also affect the overturning circulation. Seaglider sections with high spatial resolution are used to quantify the eddy exchange between the East Greenland Current and the Greenland Sea. Measurements from Argo floats provide information about the large-scale and long-term hydrographic development in the deep basins.

  18. Global Mean Sea Level during 2004-2008 from Jason, GRACE, and Argo: A Discussion of Systematic Errors (Invited)

    NASA Astrophysics Data System (ADS)

    Ray, R. D.; Beckley, B. D.; Boy, J.; Jacob, S.; Lemoine, F. G.; Luthcke, S. B.; Zelensky, N. P.

    2009-12-01

    The global mean sea level curve as measured by Jason satellite altimetry represents the combined signal of steric and eustatic sea-level variations. In principle, the former can be determined by the Argo hydrographic network (excepting that part arising from the abyssal depths) and the latter by GRACE satellite gravity measurements. For the period 2004 through 2008 the consistency between these systems for both the mean sea level trend and the seasonal cycle is encouraging; see recent work by Cazenave, Leuliette, and others. Yet all three systems are susceptible to an astonishing variety of systematic errors. This paper attempts to bound a few of them. For the satellite systems (Jason and GRACE) errors in the terrestrial reference frame, including the location of the geocenter, continue to be problematic. Jason results are also affected by calibration issues, especially for the radiometer. Tide gauge comparisons are critical, but they do not completely solve calibration uncertainties. For Argo we highlight uncertainties related to (a) interpolation across empty stretches of ocean and (b) aliasing from high-wavenumber variability, but as Willis et al. have shown, instrumental calibration errors can be even more important.

  19. Analyses of phenotype and ARGOS and ASY1 expression in a ploidy Chinese cabbage series derived from one haploid.

    PubMed

    Gu, Ai Xia; Zhao, Jian Jun; Li, Li Min; Wang, Yan Hua; Zhao, Yu Jing; Hua, Fan; Xu, Yuan Chao; Shen, Shu Xing

    2016-03-01

    The aim of this research was to improve our understanding of how ploidy level influences phenotype and gene expression in Chinese cabbage (Brassica rapa L. ssp. pekinensis). Haploid plants (2n = 10) was induced by 0.2% colchicine to produce diploid (2n = 20) and tetraploid plants (2n = 40). The aneuploid (2n = 24) was also obtained by hybridization between diploid plants as the female and tetraploid plants. The ploidy levels of all plants were identified through chromosome counts and flow cytometry. Leaves and petals became larger as the ploidy level increased from haploid to diploid, and from aneuploid to tetraploid. Similarly, expression of ARGOS was regulated by genome size, increasing in parallel with the level of ploidy. Among the four ploidy types, expression was stronger in the floral buds than in the leaves. Expression by ASY1 also differed according to ploidy level, being highest in diploid plants, followed in order by tetraploids. Expression was similar between haploids and aneuploids at two stages-prior to and after meiosis-but was higher in the haploids during meiosis. When buds were compared within the same ploidy type at different stages, ASY1 expression was obviously higher during meiosis than either before or after. Our study demonstrated the generation and phenotype of a ploidy Chinese cabbage series derived from one haploid. Expression of genes ARGOS and ASY1 were modulated by genome size in this ploidy series, and the regulated patterns of the two genes was different.

  20. Particulate concentration and seasonal dynamics in the mesopelagic ocean based on the backscattering coefficient measured with Biogeochemical-Argo floats

    NASA Astrophysics Data System (ADS)

    Poteau, Antoine; Boss, Emmanuel; Claustre, Hervé

    2017-07-01

    We explore a novel and spatially extensive data set obtained from Biogeochemical-Argo (or BGC-Argo) floats, containing 16,796 profiles of the particulate backscattering coefficient at 700 nm (bbp(700)) measured with three different sensors. We focus at the 900-950m depth interval (within the mesopelagic), where we found values to be relatively constant. While we find significant differences between estimates of bbp(700) obtained with different sensors (≈30% disagreement), the median values in most oceanic regions obtained with a single type of sensor are within 50% of each other and are consistent with measurements of suspended mass conducted in the early 1970s. Deviations from the quasi-constant background value likely indicate times and locations associated with higher particulate export to depth. Indeed, we observe that in productive high-latitude regions, a deep seasonal signal is observed, with enhanced values recorded a few months after surface spring/summer maximal concentrations. In addition, the deep bbp(700) is highest in regions exhibiting suboxic-anoxic conditions (e.g., Northern Indian Ocean), which have been associated with local particulate production as well as reduced particle flux attenuation.

  1. OBSERVATION OF TeV GAMMA RAYS FROM THE CYGNUS REGION WITH THE ARGO-YBJ EXPERIMENT

    SciTech Connect

    Bartoli, B.; Catalanotti, S.; Bernardini, P.; Bleve, C.; Bi, X. J.; Cao, Z.; Chen, S. Z.; Chen, Y.; Bolognino, I.; Branchini, P.; Budano, A.; Calabrese Melcarne, A. K.; Cardarelli, R.; Cattaneo, C.; Chen, T. L.; Creti, P.; Cui, S. W.; Dai, B. Z.; D'Ali Staiti, G.; Collaboration: ARGO-YBJ Collaboration; and others

    2012-02-15

    We report the observation of TeV {gamma}-rays from the Cygnus region using the ARGO-YBJ data collected from 2007 November to 2011 August. Several TeV sources are located in this region including the two bright extended MGRO J2019+37 and MGRO J2031+41. According to the Milagro data set, at 20 TeV MGRO J2019+37 is the most significant source apart from the Crab Nebula. No signal from MGRO J2019+37 is detected by the ARGO-YBJ experiment, and the derived flux upper limits at the 90% confidence level for all the events above 600 GeV with medium energy of 3 TeV are lower than the Milagro flux, implying that the source might be variable and hard to be identified as a pulsar wind nebula. The only statistically significant (6.4 standard deviations) {gamma}-ray signal is found from MGRO J2031+41, with a flux consistent with the measurement by Milagro.

  2. Temperature signature of high latitude Atlantic boundary currents revealed by marine mammal-borne sensor and Argo data

    NASA Astrophysics Data System (ADS)

    Grist, Jeremy P.; Josey, Simon A.; Boehme, Lars; Meredith, Michael P.; Davidson, Fraser J. M.; Stenson, Garry B.; Hammill, Mike O.

    2011-08-01

    Results from the development and analysis of a novel temperature dataset for the high latitude North-West Atlantic are presented. The new 1° gridded dataset (“ATLAS”) has been produced from about 13,000 Argo and 48,000 marine mammal (hooded seal, harp seal, grey seal and beluga) profiles spanning 2004-8. These data sources are highly complementary as marine mammals greatly enhance shelf region coverage where Argo floats are absent. ATLAS reveals distinctive boundary current related temperature minima in the Labrador Sea (-1.1°C) and at the east Greenland coast (1.8°C), largely absent in the widely-used Levitus'09 and EN3v2a datasets. The ATLAS 0-500 m average temperature is lower than Levitus'09 and EN3v2a by up to 3°C locally. Differences are strongest from 0-300 m and persist at reduced amplitude from 300-500 m. Our results clearly reveal the value of marine mammal-borne sensors for a reliable description of the North-West Atlantic at a time of rapid change.

  3. An Ensemble Recentering Kalman Filter with an Application to Argo Temperature Data Assimilation into the NASA GEOS-5 Coupled Model

    NASA Technical Reports Server (NTRS)

    Keppenne, Christian L.

    2013-01-01

    A two-step ensemble recentering Kalman filter (ERKF) analysis scheme is introduced. The algorithm consists of a recentering step followed by an ensemble Kalman filter (EnKF) analysis step. The recentering step is formulated such as to adjust the prior distribution of an ensemble of model states so that the deviations of individual samples from the sample mean are unchanged but the original sample mean is shifted to the prior position of the most likely particle, where the likelihood of each particle is measured in terms of closeness to a chosen subset of the observations. The computational cost of the ERKF is essentially the same as that of a same size EnKF. The ERKF is applied to the assimilation of Argo temperature profiles into the OGCM component of an ensemble of NASA GEOS-5 coupled models. Unassimilated Argo salt data are used for validation. A surprisingly small number (16) of model trajectories is sufficient to significantly improve model estimates of salinity over estimates from an ensemble run without assimilation. The two-step algorithm also performs better than the EnKF although its performance is degraded in poorly observed regions.

  4. Experiments with the nonlinear and chaotic behaviour of the multiplicative algebraic reconstruction technique (MART) algorithm for computed tomography

    NASA Astrophysics Data System (ADS)

    Badea, Cristian; Gordon, Richard

    2004-04-01

    Among the iterative reconstruction algorithms for tomography, the multiplicative algebraic reconstruction technique (MART) has two advantages that make it stand out from other algorithms: it confines the image (and therefore the projection data) to the convex hull of the patient, and it maximizes entropy. In this paper, we have undertaken a series of experiments to determine the importance of MART nonlinearity to image quality. Variants of MART were implemented aiming to exploit and exaggerate the nonlinear properties of the algorithm. We introduce the Power MART, Boxcar Averaging MART and Bouncing MART algorithms. Power MART is linked to the relaxation concept. Its behaviour is similar to that of the chaos of a logistic equation. There appears to be an antagonism between increasing nonlinearity and noise in the projection data. The experiments confirm our general observation that regularization as a means of solving simultaneous linear equations that are underdetermined is suboptimal: it does not necessarily select the correct image from the hyperplane of solutions, and so does not maximize the image quality:x-ray dose ratio. Our investigations prove that there is scope to optimize CT algorithms and thereby achieve greater dose reduction.

  5. Project Argo: The design and analysis of an all-propulsive and an aeroassisted version of a manned space transportation vehicle

    NASA Technical Reports Server (NTRS)

    1989-01-01

    Project Argo is the design of a manned Space Transportation Vehicle (STV) that would transport payloads between LEO (altitude lying between 278 to 500 km above the Earth) and GEO (altitude is approximately 35,800 km above the Earth) and would be refueled and refurbished at the Space Station Freedom. Argo would be man's first space-based manned vehicle and would provide a crucial link to geosynchronous orbit where the vast majority of satellites are located. The vehicle could be built and launched shortly after the space station and give invaluable space experience while serving as a workhorse to deliver and repair satellites. Eventually, if a manned space station is established in GEO, then Argo could serve as the transport between the Space Station Freedom and a Geostation. If necessary, modifications could be made to allow the vehicle to reach the moon or possibly Mars. Project Argo is unique in that it consists of the design and comparison of two different concepts to accomplish the same mission. The first is an all-propulsive vehicle which uses chemical propulsion for all of its major maneuvers between LEO and GEO. The second is a vehicle that uses aeroassisted braking during its return from GEO to LEO by passing through the upper portions of the atmosphere.

  6. The vitamin D analog, MART-10, represses metastasis potential via downregulation of epithelial-mesenchymal transition in pancreatic cancer cells.

    PubMed

    Chiang, Kun-Chun; Yeh, Chun-Nan; Hsu, Jun-Te; Jan, Yi-Yin; Chen, Li-Wei; Kuo, Sheng-Fong; Takano, Masashi; Kittaka, Atsushi; Chen, Tai C; Chen, Wen-Tsung; Pang, Jong-Hwei S; Yeh, Ta-Sen; Juang, Horng-Heng

    2014-11-28

    Pancreatic cancer (PDA) is a devastating disease and there is no effective treatment available at present. To develop new regiments against PDA is urgently needed. Previously we have shown that vitamin D analog, MART-10 (19-nor-2α-(3-hydroxypropyl)-1α,25(OH)2D3), exerted potent antiproliferative effect on PDA in vitro and in vivo without causing hypercalcemia. Since metastasis is the major cause of PDA-related death, we therefore investigate the anti-metastasis effect of MART-10 on PDA. Our results showed that both 1α,25(OH)2D3 and MART-10 repressed migration and invasion of BxPC-3 and PANC cells with MART-10 much more potent than 1α,25(OH)2D3. 1α,25(OH)2D3 and MART-10 inhibited epithelial-mesenchymal transition (EMT) in pancreatic cancer cells through downregulation of Snail, Slug, and Vimentin expression in BxPC-3 and PANC cells. MART-10 further blocked cadherin switch (from E-cadherin to N-cadherin) in BxPC-3 cells. The F-actin synthesis in the cytoplasm of BxPC-3 cells was also repressed by 1α,25(OH)2D3 and MART-10 as determined by immunofluorescence stain. Both 1α,25(OH)2D3 and MART-10 decreased MMP-2 and -9 secretion in BxPC-3 cells as determined by western blot and zymography. Collectively, MART-10 should be deemed as a promising regimen against PDA.

  7. [Water and energy metabolism in representatives of the genus Martes and Mustela (Mammalia: Mustelidae)].

    PubMed

    Meshcherskiĭ, I G; Rozhnov, V V; Naĭdenko, S V

    2003-01-01

    The quantities of consumed food and water, quantity and moisture content of faeces, as well as quantity and concentration of excreted urine were determined in representatives of Martes--marten (M. martes) and sable (M. zibellina)--as well as in polecat (Mustela putorius). Under the same cage conditions and free access to food, all three species had similar energy value of the daily diet. However, the level of drinking water consumption and the ratio between the quantities of arriving water and energy was reliably higher in both Martes species than in polecat. In addition, both marten and sable featured a much higher rate of evaporation loss in the overall water balance and, consequently, a higher quantity of heat dissipated with evaporation as compared to polecat. Comparison of the obtained and previous data (Sokolov et al., 1995; Rozhnov, 1991) allowed us to propose that the mentioned differences can be specific for representatives of Martes and Mustela genera irrespective of ecological specialization of particular species.

  8. The BioMart community portal: an innovative alternative to large, centralized data repositories

    USDA-ARS?s Scientific Manuscript database

    The BioMart Community Portal (www.biomart.org) is a community-driven effort to provide a unified interface to biomedical databases that are distributed worldwide. The portal provides access to numerous database projects supported by 30 scientific organizations. It includes over 800 different biologi...

  9. An evaluation of a weaning index for wild fishers (Pekania [Martes] pennanti) in California

    Treesearch

    Sean M. Matthews; J. Mark Higley; John T. Finn; Kerry M. Rennie; Craig M. Thompson; Kathryn L. Purcell; Rick A. Sweitzer; Sandra L. Haire; Paul R. Sievert; Todd K. Fuller

    2013-01-01

    Conservation concern for fishers (Pekania [Martes] pennanti) in the Pacific states has highlighted a need to develop cost-effective methods of monitoring reproduction in extant and reintroduced fisher populations. We evaluated the efficacy of nipple size as a predictive index of weaning success for females...

  10. Genetic diversity and structure of the fisher (Martes pennanti) in a peninsular and peripheral metapopulation.

    Treesearch

    Samantha M. Wisely; Steven W. Buskirk; Gregory A. Russell; Keith B. Aubry; William I. Zielinski

    2004-01-01

    Evolutionary processes can be strongly affected by landscape features. In vagile carnivores that disperse widely, however, genetic structure has been found to be minimal. Using microsatellite DNA primers developed for other mustelids, we found that populations of a vagile forest carnivore, the fisher (Martes pennanti), exhibit high genetic...

  11. Flavonoids from acai (euterpe oleracea mart.) Pulp and their antioxidant and anti-inflammatory activities

    USDA-ARS?s Scientific Manuscript database

    Five flavonoids, (2S,3S)-dihyrokaempferol 3-O-beta-D-glucoside (1) and its isomer (2R,3R)-dihydrokaempferol 3-O-'-D-glucoside (2) , isovitexin (3), velutin (4) and 5,4'-dihydroxy-7,3',5'-trimethoxyflavone (5), were isolated from acai (Euterpe oleracea Mart.) pulp. The structures of these compounds ...

  12. Soboliphyme baturini infection does not affect the nutritional condition of American marten (Martes americana) in Alaska

    Treesearch

    J.G. Thomas; J.N. Pauli; E. Donaldio; S.W. Buskirk

    2008-01-01

    Soboliphyme baturini, a stomach-dwelling nematode of American martens (Martes americana). reaches high levels of infection; however, its effects on the nutritional condition of the host are unknown. To understand the effects of this parasite on American martens, we collected S. baturini and measured abdominal fat...

  13. EnsMart: A Generic System for Fast and Flexible Access to Biological Data

    PubMed Central

    Kasprzyk, Arek; Keefe, Damian; Smedley, Damian; London, Darin; Spooner, William; Melsopp, Craig; Hammond, Martin; Rocca-Serra, Philippe; Cox, Tony; Birney, Ewan

    2004-01-01

    The EnsMart system (www.ensembl.org/EnsMart) provides a generic data warehousing solution for fast and flexible querying of large biological data sets and integration with third-party data and tools. The system consists of a query-optimized database and interactive, user-friendly interfaces. EnsMart has been applied to Ensembl, where it extends its genomic browser capabilities, facilitating rapid retrieval of customized data sets. A wide variety of complex queries, on various types of annotations, for numerous species are supported. These can be applied to many research problems, ranging from SNP selection for candidate gene screening, through cross-species evolutionary comparisons, to microarray annotation. Users can group and refine biological data according to many criteria, including cross-species analyses, disease links, sequence variations, and expression patterns. Both tabulated list data and biological sequence output can be generated dynamically, in HTML, text, Microsoft Excel, and compressed formats. A wide range of sequence types, such as cDNA, peptides, coding regions, UTRs, and exons, with additional upstream and downstream regions, can be retrieved. The EnsMart database can be accessed via a public Web site, or through a Java application suite. Both implementations and the database are freely available for local installation, and can be extended or adapted to `non-Ensembl' data sets. PMID:14707178

  14. The BioMart community portal: an innovative alternative to large, centralized data repositories.

    PubMed

    Smedley, Damian; Haider, Syed; Durinck, Steffen; Pandini, Luca; Provero, Paolo; Allen, James; Arnaiz, Olivier; Awedh, Mohammad Hamza; Baldock, Richard; Barbiera, Giulia; Bardou, Philippe; Beck, Tim; Blake, Andrew; Bonierbale, Merideth; Brookes, Anthony J; Bucci, Gabriele; Buetti, Iwan; Burge, Sarah; Cabau, Cédric; Carlson, Joseph W; Chelala, Claude; Chrysostomou, Charalambos; Cittaro, Davide; Collin, Olivier; Cordova, Raul; Cutts, Rosalind J; Dassi, Erik; Di Genova, Alex; Djari, Anis; Esposito, Anthony; Estrella, Heather; Eyras, Eduardo; Fernandez-Banet, Julio; Forbes, Simon; Free, Robert C; Fujisawa, Takatomo; Gadaleta, Emanuela; Garcia-Manteiga, Jose M; Goodstein, David; Gray, Kristian; Guerra-Assunção, José Afonso; Haggarty, Bernard; Han, Dong-Jin; Han, Byung Woo; Harris, Todd; Harshbarger, Jayson; Hastings, Robert K; Hayes, Richard D; Hoede, Claire; Hu, Shen; Hu, Zhi-Liang; Hutchins, Lucie; Kan, Zhengyan; Kawaji, Hideya; Keliet, Aminah; Kerhornou, Arnaud; Kim, Sunghoon; Kinsella, Rhoda; Klopp, Christophe; Kong, Lei; Lawson, Daniel; Lazarevic, Dejan; Lee, Ji-Hyun; Letellier, Thomas; Li, Chuan-Yun; Lio, Pietro; Liu, Chu-Jun; Luo, Jie; Maass, Alejandro; Mariette, Jerome; Maurel, Thomas; Merella, Stefania; Mohamed, Azza Mostafa; Moreews, Francois; Nabihoudine, Ibounyamine; Ndegwa, Nelson; Noirot, Céline; Perez-Llamas, Cristian; Primig, Michael; Quattrone, Alessandro; Quesneville, Hadi; Rambaldi, Davide; Reecy, James; Riba, Michela; Rosanoff, Steven; Saddiq, Amna Ali; Salas, Elisa; Sallou, Olivier; Shepherd, Rebecca; Simon, Reinhard; Sperling, Linda; Spooner, William; Staines, Daniel M; Steinbach, Delphine; Stone, Kevin; Stupka, Elia; Teague, Jon W; Dayem Ullah, Abu Z; Wang, Jun; Ware, Doreen; Wong-Erasmus, Marie; Youens-Clark, Ken; Zadissa, Amonida; Zhang, Shi-Jian; Kasprzyk, Arek

    2015-07-01

    The BioMart Community Portal (www.biomart.org) is a community-driven effort to provide a unified interface to biomedical databases that are distributed worldwide. The portal provides access to numerous database projects supported by 30 scientific organizations. It includes over 800 different biological datasets spanning genomics, proteomics, model organisms, cancer data, ontology information and more. All resources available through the portal are independently administered and funded by their host organizations. The BioMart data federation technology provides a unified interface to all the available data. The latest version of the portal comes with many new databases that have been created by our ever-growing community. It also comes with better support and extensibility for data analysis and visualization tools. A new addition to our toolbox, the enrichment analysis tool is now accessible through graphical and web service interface. The BioMart community portal averages over one million requests per day. Building on this level of service and the wealth of information that has become available, the BioMart Community Portal has introduced a new, more scalable and cheaper alternative to the large data stores maintained by specialized organizations. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

  15. A miniature Marine Aerosol Reference Tank (miniMART) as a compact breaking wave analogue

    NASA Astrophysics Data System (ADS)

    Stokes, M. Dale; Deane, Grant; Collins, Douglas B.; Cappa, Christopher; Bertram, Timothy; Dommer, Abigail; Schill, Steven; Forestieri, Sara; Survilo, Mathew

    2016-09-01

    In order to understand the processes governing the production of marine aerosols, repeatable, controlled methods for their generation are required. A new system, the miniature Marine Aerosol Reference Tank (miniMART), has been designed after the success of the original MART system, to approximate a small oceanic spilling breaker by producing an evolving bubble plume and surface foam patch. The smaller tank utilizes an intermittently plunging jet of water produced by a rotating water wheel, into an approximately 6 L reservoir to simulate bubble plume and foam formation and generate aerosols. This system produces bubble plumes characteristic of small whitecaps without the large external pump inherent in the original MART design. Without the pump it is possible to easily culture delicate planktonic and microbial communities in the bulk water during experiments while continuously producing aerosols for study. However, due to the reduced volume and smaller plunging jet, the absolute numbers of particles generated are approximately an order of magnitude less than in the original MART design.

  16. La Verneda-Sant Martí Adult School: A Reference for Neighborhood Popular Education

    ERIC Educational Resources Information Center

    Aubert, Adrianna; Villarejo, Bea; Cabré, Joan; Santos, Tatiana

    2016-01-01

    Background/Context: The Adult School of La Verneda Sant Martí, located in Barcelona, Spain, is a reference at the international level because of its trajectory and its contributions to the transformative movement in democratic education. The school was created in 1978 to address the demands of the working-class residents of the La Verneda…

  17. Canine Distemper in an isolated population of fishers (Martes pennanti) from California

    Treesearch

    Stefan m. Keller; Mourad Gabriel; Karen A. Terio; Edward J. Dubovi; Elizabeth Van Wormer; Rick Sweitzer; Reginald Barret; Craig Thompson; Kathryn Purcell; Linda. Munson

    2012-01-01

    Four fishers (Martes pennanti) from an insular population in the southern Sierra Nevada Mountains, California, USA died as a consequence of an infection with canine distemper virus (CDV) in 2009. Three fishers were found in close temporal and spatial relationship; the fourth fisher died 4 mo later at a 70 km distance from the initial group. Gross...

  18. Screening a core collection of citrus genetic resources for resistance to Fusarium solani (Mart) Sacc

    USDA-ARS?s Scientific Manuscript database

    A causal agent for Dry root rot (DRR) of citrus has not been definitively identified, but the organism most consistently associated with DRR is Fusarium solani (Mart.) Sacc. To efficiently screen a citrus germplasm collection for resistance to F. solani, a core subset of the collection was evaluated...

  19. Rescuing Red Riding Hood: Carmen Martín Gaite's "Caperucita en Manhattan"

    ERIC Educational Resources Information Center

    Brown, Joan L.

    2017-01-01

    Carmen Martín Gaite's "Caperucita en Manhattan" is a Young Adult novel ahead of its time. If this category had existed in Spain when it was published, it is likely that it would have earned the critical recognition it deserves. The novel's exciting plot, captivating prose, wise cultural commentary, factual content, sense of humor, and…

  20. Eruption Constraints for a Young Channelized Lava Flow, Marte Vallis, Mars

    NASA Technical Reports Server (NTRS)

    Therkelsen, J. P.; Santiago, S. S.; Grosfils, E. B.; Sakimoto, S. E. H.; Mendelson, C. V.; Bleacher, J. E.

    2001-01-01

    This study constrains flow rates for a specific channelized lava flow in Marte Vallis, Mars. We measured slope-gradient, channel width, and channel depth. Our results are similar to other recent studies which suggests similarities to long, terrestrial basaltic flow. Additional information is contained in the original extended abstract.

  1. Winter home-range characteristics of American Marten (Martes americana) in Northern Wisconsin

    Treesearch

    Joseph B. Dumyahn; Patrick A. Zollner

    2007-01-01

    We estimated home-range size for American marten (Martes americana) in northern Wisconsin during the winter months of 2001-2004, and compared the proportion of cover-type selection categories (highly used, neutral and avoided) among home-ranges (95% fixed-kernel), core areas (50% fixed-kernel) and the study area. Average winter homerange size was 3....

  2. Effects of season on occupancy and implications for habitat modeling: the Pacific marten Martes caurina

    Treesearch

    William J. Zielinski; Katie M. Moriarty; Jim Baldwin; Thomas A. Kirk; Keith M. Slauson; Heather L. Rustigian-Romsos; Wayne D. Spencer

    2015-01-01

    Season affects many characteristics of populations and, as a result, the interpretations of surveys conducted at different seasons. We explored seasonal variation in occupancy using data from four studies on the Pacific marten Martes caurina. Detection surveys were conducted during winter and summer using either cameras or track stations. We...

  3. Estimating trend in occupancy for the Southern Sierra fisher Martes pennanti population

    Treesearch

    William J. Zielinski; James A. Baldwin; Richard L. Truex; Jody M. Tucker; Patricia A. Flebbe

    2013-01-01

    Carnivores are important elements of biodiversity, not only because of their role in transferring energy and nutrients, but also because they influence the structure of the communities where they occur. The fisher Martes pennanti is amammalian carnivore that is associated with late-successional mixed forests in the Sierra Nevada in California, and...

  4. Numerical Simulations to Assess ART and MART Performance for Ionospheric Tomography of Chapman Profiles.

    PubMed

    Prol, Fabricio S; Camargo, Paulo O; Muella, Marcio T A H

    2017-07-31

    The incomplete geometrical coverage of the Global Navigation Satellite System (GNSS) makes the ionospheric tomographic system an ill-conditioned problem for ionospheric imaging. In order to detect the principal limitations of the ill-conditioned tomographic solutions, numerical simulations of the ionosphere are under constant investigation. In this paper, we show an investigation of the accuracy of Algebraic Reconstruction Technique (ART) and Multiplicative ART (MART) for performing tomographic reconstruction of Chapman profiles using a simulated optimum scenario of GNSS signals tracked by ground-based receivers. Chapman functions were used to represent the ionospheric morphology and a set of analyses was conducted to assess ART and MART performance for estimating the Total Electron Content (TEC) and parameters that describes the Chapman function. The results showed that MART performed better in the reconstruction of the electron density peak and ART gave a better representation for estimating TEC and the shape of the ionosphere. Since we used an optimum scenario of the GNSS signals, the analyses indicate the intrinsic problems that may occur with ART and MART to recover valuable information for many applications of Telecommunication, Spatial Geodesy and Space Weather.

  5. COMPLEX HOST-PARASITE SYSTEMS IN MARTES: IMPLICATIONS FOR CONSERVATION BIOLOGY OF ENDEMIC FAUNAS.

    USDA-ARS?s Scientific Manuscript database

    Complex assemblages of hosts and parasites reveal insights about biogeography and ecology and inform us about processes which serve to structure faunal diversity and the biosphere in space and time. Exploring aspects of parasite diversity among martens (species of Martes) and other mustelids reveal...

  6. La Verneda-Sant Martí Adult School: A Reference for Neighborhood Popular Education

    ERIC Educational Resources Information Center

    Aubert, Adrianna; Villarejo, Bea; Cabré, Joan; Santos, Tatiana

    2016-01-01

    Background/Context: The Adult School of La Verneda Sant Martí, located in Barcelona, Spain, is a reference at the international level because of its trajectory and its contributions to the transformative movement in democratic education. The school was created in 1978 to address the demands of the working-class residents of the La Verneda…

  7. When reintroductions are augmentations: the genetic legacy of the fisher (Martes pennanti) in Montana

    Treesearch

    Ray S. Vinkey; Michael K. Schwartz; Kevin S. McKelvey; Kerry R. Foresman; Kristine L. Pilgrim; Brian J. Giddings; Eric C. Lofroth

    2006-01-01

    Fishers (Martes pennanti) were purportedly extirpated from Montana by 1930 and extant populations are assumed to be descended from translocated fishers. To determine the lineage of fisher populations, we sequenced 2 regions of the mitochondrial DNA genome from 207 tissue samples from British Columbia, Minnesota, Wisconsin, and Montana. In...

  8. EnsMart: a generic system for fast and flexible access to biological data.

    PubMed

    Kasprzyk, Arek; Keefe, Damian; Smedley, Damian; London, Darin; Spooner, William; Melsopp, Craig; Hammond, Martin; Rocca-Serra, Philippe; Cox, Tony; Birney, Ewan

    2004-01-01

    The EnsMart system (www.ensembl.org/EnsMart) provides a generic data warehousing solution for fast and flexible querying of large biological data sets and integration with third-party data and tools. The system consists of a query-optimized database and interactive, user-friendly interfaces. EnsMart has been applied to Ensembl, where it extends its genomic browser capabilities, facilitating rapid retrieval of customized data sets. A wide variety of complex queries, on various types of annotations, for numerous species are supported. These can be applied to many research problems, ranging from SNP selection for candidate gene screening, through cross-species evolutionary comparisons, to microarray annotation. Users can group and refine biological data according to many criteria, including cross-species analyses, disease links, sequence variations, and expression patterns. Both tabulated list data and biological sequence output can be generated dynamically, in HTML, text, Microsoft Excel, and compressed formats. A wide range of sequence types, such as cDNA, peptides, coding regions, UTRs, and exons, with additional upstream and downstream regions, can be retrieved. The EnsMart database can be accessed via a public Web site, or through a Java application suite. Both implementations and the database are freely available for local installation, and can be extended or adapted to 'non-Ensembl' data sets.

  9. Massive infestation with fur mites (Lynxacarus mustelae) of a stone marten (Martes foina) from Tyrol.

    PubMed

    Visser, Martin; Messner, Christian; Rehbein, Steffen

    2011-10-01

    A massive infestation with Lynxacarus mustelae (Megnin, 1885) (Acari, Astigmata, Listrophoridae) was diagnosed in a stone marten (Martes foina) from Tyrol, Austria. In addition, Ixodes rugicollis and Trichodectes retusus are reported for the first time in Austria, and the five species of helminths found (Capillaria aerophila, C. mustelorum, C. paranalis, C. plica, Molineus patens) are first records in the stone marten in the country.

  10. Camera trapping estimates of density and survival of fishers (Martes pennanti)

    Treesearch

    Mark J. Jordan; Reginald H. Barrett; Kathryn L. Purcell

    2011-01-01

    Developing efficient monitoring strategies for species of conservation concern is critical to ensuring their persistence. We have developed a method using camera traps to estimate density and survival in mesocarnivores and tested it on a population of fishers Martes pennanti in an area of approximately 300 km2 of the southern...

  11. Multi scale habitat relationships of Martes americana in northern Idaho, U.S.A.

    Treesearch

    Tzeidle N. Wasserman; Samuel A. Cushman; David O. Wallin; Jim Hayden

    2012-01-01

    We used bivariate scaling and logistic regression to investigate multiple-scale habitat selection by American marten (Martes americana). Bivariate scaling reveals dramatic differences in the apparent nature and strength of relationships between marten occupancy and a number of habitat variables across a range of spatial scales. These differences include reversals in...

  12. The BioMart community portal: an innovative alternative to large, centralized data repositories

    PubMed Central

    Smedley, Damian; Haider, Syed; Durinck, Steffen; Pandini, Luca; Provero, Paolo; Allen, James; Arnaiz, Olivier; Awedh, Mohammad Hamza; Baldock, Richard; Barbiera, Giulia; Bardou, Philippe; Beck, Tim; Blake, Andrew; Bonierbale, Merideth; Brookes, Anthony J.; Bucci, Gabriele; Buetti, Iwan; Burge, Sarah; Cabau, Cédric; Carlson, Joseph W.; Chelala, Claude; Chrysostomou, Charalambos; Cittaro, Davide; Collin, Olivier; Cordova, Raul; Cutts, Rosalind J.; Dassi, Erik; Genova, Alex Di; Djari, Anis; Esposito, Anthony; Estrella, Heather; Eyras, Eduardo; Fernandez-Banet, Julio; Forbes, Simon; Free, Robert C.; Fujisawa, Takatomo; Gadaleta, Emanuela; Garcia-Manteiga, Jose M.; Goodstein, David; Gray, Kristian; Guerra-Assunção, José Afonso; Haggarty, Bernard; Han, Dong-Jin; Han, Byung Woo; Harris, Todd; Harshbarger, Jayson; Hastings, Robert K.; Hayes, Richard D.; Hoede, Claire; Hu, Shen; Hu, Zhi-Liang; Hutchins, Lucie; Kan, Zhengyan; Kawaji, Hideya; Keliet, Aminah; Kerhornou, Arnaud; Kim, Sunghoon; Kinsella, Rhoda; Klopp, Christophe; Kong, Lei; Lawson, Daniel; Lazarevic, Dejan; Lee, Ji-Hyun; Letellier, Thomas; Li, Chuan-Yun; Lio, Pietro; Liu, Chu-Jun; Luo, Jie; Maass, Alejandro; Mariette, Jerome; Maurel, Thomas; Merella, Stefania; Mohamed, Azza Mostafa; Moreews, Francois; Nabihoudine, Ibounyamine; Ndegwa, Nelson; Noirot, Céline; Perez-Llamas, Cristian; Primig, Michael; Quattrone, Alessandro; Quesneville, Hadi; Rambaldi, Davide; Reecy, James; Riba, Michela; Rosanoff, Steven; Saddiq, Amna Ali; Salas, Elisa; Sallou, Olivier; Shepherd, Rebecca; Simon, Reinhard; Sperling, Linda; Spooner, William; Staines, Daniel M.; Steinbach, Delphine; Stone, Kevin; Stupka, Elia; Teague, Jon W.; Dayem Ullah, Abu Z.; Wang, Jun; Ware, Doreen; Wong-Erasmus, Marie; Youens-Clark, Ken; Zadissa, Amonida; Zhang, Shi-Jian; Kasprzyk, Arek

    2015-01-01

    The BioMart Community Portal (www.biomart.org) is a community-driven effort to provide a unified interface to biomedical databases that are distributed worldwide. The portal provides access to numerous database projects supported by 30 scientific organizations. It includes over 800 different biological datasets spanning genomics, proteomics, model organisms, cancer data, ontology information and more. All resources available through the portal are independently administered and funded by their host organizations. The BioMart data federation technology provides a unified interface to all the available data. The latest version of the portal comes with many new databases that have been created by our ever-growing community. It also comes with better support and extensibility for data analysis and visualization tools. A new addition to our toolbox, the enrichment analysis tool is now accessible through graphical and web service interface. The BioMart community portal averages over one million requests per day. Building on this level of service and the wealth of information that has become available, the BioMart Community Portal has introduced a new, more scalable and cheaper alternative to the large data stores maintained by specialized organizations. PMID:25897122

  13. Characterizing the molecular variation among American marten (Martes americana) subspecies from Oregon and California

    Treesearch

    Keith M. Slauson; Bill Zielinski; Karen D. Stone

    2009-01-01

    We investigated the subspecific identity of a rediscovered population of American martens within the range of a presumed extinct subspecies (Martes americana humboldtensis) by comparing mitochondrial DNA sequence diversity from contemporary individuals within the described ranges of M. a. humboldtensis, nearby ranges of

  14. Molecular evolution and adaptation of the mitochondrial cytochrome b gene in the subgenus Martes.

    PubMed

    Li, B; Malyarchuk, B; He, X B; Derenko, M

    2013-09-23

    Martes species represent a typical example of rapid evolutionary radiation and a recent speciation event. To identify regions of the genome that experienced adaptive evolution, which might provide clues to their functional importance and may be informative about the features that make each species unique, we sought evidence of molecular adaptation in the mitochondrial DNA (mtDNA) cytochrome b gene in the subgenus Martes. Complete sequences of the cytochrome b gene were obtained from 87 samples, including 49 sables, 28 pine martens, and 10 stone martens, and were combined with mtDNA sequences of other true martens, such as M. melampus and M. americana. Analysis of the cytochrome b gene variation in true martens has shown that the evolution of this gene is under negative selection. In contrast, positive selection on the cytochrome b protein has been detected by means of the software TreeSAAP using a phylogenetic reconstruction of Martes taxa. Signatures of adaptive variation in cytochrome b were restricted to the transmembrane domains, which likely function as proton pumps. We compared results of different methods for testing selection and molecular adaptation, and we supposed that the radical changes of the cytochrome b amino acid residues in the subgenus Martes may be the result of molecular adaptation to specific environmental conditions coupled with species dispersals.

  15. Exploración del Nuevo Laboratorio Científico de Marte

    NASA Image and Video Library

    Únase a Fernando Abilleira, un analista de trayectoria de la NASA para la Oficina de Exploración de Marte, y conozca las nuevas tecnologías que el nuevo robot Curiosity del Laboratorio Científico d...

  16. Ancient DNA confirms native Rocky Mountain fisher (Martes pennanti) avoided early 20th century extinction

    Treesearch

    Michael K. Schwartz

    2007-01-01

    Until recently it was assumed that fishers (Martes pennanti) in the Rocky Mountains all were descended from reintroduced stocks. However, a recent study reported that mitochondrial DNA (cytochrome-b and control region) haplotypes of fishers found only in west-central Montana are likely derived from a relic population of fishers that escaped harvests conducted in the...

  17. Cytotoxic effects of Euterpe oleracea Mart. in malignant cell lines

    PubMed Central

    2014-01-01

    Background Euterpe oleracea Mart., a plant from the Amazon region, is commonly known as açaí or juçara; it has high nutritional value and elevated levels of lipids, proteins, and minerals. Açaí is an abundant and much consumed fruit by the Amazon local population, and studies have demonstrated that it is rich in phytochemicals with antioxidant, anti-inflammatory, and anticancer activities. Therefore, the aim of this study was to test this plant for anticancer activity in different human malignant cell lines. Methods Cell lines derived from breast and colorectal adenocarcinomas were treated with 10, 20, and 40 μg/mL of bark, seed, and total açaí fruit hydroalcoholic extracts for 24 and 48 h. After treatment, cell viability was measured using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays, and cell morphological features were observed by light and transmission electron microscopy. The type of cell death was also evaluated. The data were analyzed statistically by one-way analysis of variance (ANOVA), followed by Dunnett’s or Tukey’s post hoc tests, as appropriate. Results We observed that of all the cell lines tested, MCF-7 was the only line that responded to açaí treatment. The extracts caused significant reduction (p < 0.01) in cell viability and altered cell morphological features by inducing the appearance of autophagic vacuoles, as observed by transmission electron microscopy. Furthermore, increased expression of LC3BII, a protein marker of autophagosome formation, was observed by western blotting. Caspase Glo™ assays and morphologic observations by DAPI nuclear staining and transmission electron microscopy did not indicate any apoptotic events. Conclusions The present study demonstrated that açaí possesses antitumorigenic potential in the MCF-7 cell line. Further studies are needed to identify the compound (s) responsible for this cytotoxic activity and the molecular target in the cell. This discovery of the

  18. Insertion of Argos sequences into the B-loop of epidermal growth factor results in a low-affinity ligand with strong agonistic activity.

    PubMed

    van de Poll, M L; van Vugt, M J; Lenferink, A E; van Zoelen, E J

    1997-06-17

    Recently, it has been shown that the activation of the Drosophila EGF receptor (DER) by its natural ligand Spitz is inhibited by Argos [Schweitzer, R., et al. (1995) Nature 376, 699-702]. Argos and Spitz both have an EGF-like domain which in the case of Argos differs from that of Spitz and other EGF receptor agonists in that it has an extended B-loop of 20 amino acids instead of 10 amino acids which in addition contains an unusual cluster of charged residues. To investigate whether B-loop sequences are an important determinant for receptor activation and play a causal role in the antagonistic activity of Argos, three human (h)EGF mutants were constructed in which amino acids derived from the Argos B-loop were introduced. In one mutant (E3A4E/B10), replacement of four amino acids in the B-loop of hEGF (123, E24, D27, and K28) by the corresponding Argos residues neither altered the binding affinity of the growth factor for the hEGF receptor nor did it change its ability to induce a mitogenic response. Insertion of 2 additional Argos residues (E3A4E/B12) or extension of the B-loop by 10 amino acids (E3A4E/B20) resulted, however, in a significant loss of binding affinity. In spite of this, both E3A4E/B12 and E3A4E/B20 appeared to be strong agonists for the hEGF receptor with similar dose-response curves for mitogenic activity and MAPK activation as wild-type hEGF. These data show that several nonconservative substitutions in the hEGF B-loop are tolerated without affecting receptor binding or activation. Furthermore, they show that receptor binding and receptor signaling efficiency can be uncoupled which is a prerequisite for the development of receptor antagonists.

  19. Development of a multi-data assimilation scheme to integrate Bio-Argo floats data with ocean colour satellite data into the CMEMS MFC-Biogeochemistry

    NASA Astrophysics Data System (ADS)

    Cossarini, Gianpiero; D'Ortenzio, Fabrizio; Mariotti, Laura; Mignot, Alexandre; Salon, Stefano

    2017-04-01

    The Mediterranean Sea is a very promising site to develop and test the assimilation of Bio-Argo data since 1) the Bio-Argo network is one of the densest of the global ocean, and 2) a consolidate data assimilation framework of biogeochemical variables (3DVAR-BIO, presently based on assimilation of satellite-estimated surface chlorophyll data) already exists within the CMEMS biogeochemical model system for Mediterranean Sea. The MASSIMILI project, granted by the CMEMS Service Evolution initiative, is aimed to develop the assimilation of Bio-Argo Floats data into the CMEMS biogeochemical model system of the Mediterranean Sea, by means of an upgrade of the 3DVAR-BIO scheme. Specific developments of the 3DVAR-BIO scheme focus on the estimate of new operators of the variational decomposition of the background error covariance matrix and on the implementation of the new observation operator specifically for the Bio-Argo float vertical profile data. In particular, a new horizontal covariance operator for chlorophyll, nitrate and oxygen is based on 3D fields of horizontal correlation radius calculated from a long-term reanalysis simulation. A new vertical covariance operator is built on monthly and spatial varying EOF decomposition to account for the spatiotemporal variability of vertical structure of the three variables error covariance. Further, the observation error covariance is a key factor for an effective assimilation of the Bio-Argo data into the model dynamics. The sensitivities of assimilation to the different factors are estimated. First results of the implementation of the new 3DVAR-BIO scheme show the impact of Bio-Argo data on the 3D fields of chlorophyll, nitrate and oxygen. Tuning the length scale factors of horizontal covariance, analysing the sensitivity of the observation error covariance, introducing non-diagonal biogeochemical covariance operator and non-diagonal multi-platform operator (i.e. Bio-Argo and satellite) are crucial future steps for the

  20. Circulation patterns in the deep Subtropical Northeast Atlantic with ARGO data

    NASA Astrophysics Data System (ADS)

    Calheiros, Tomas; Bashmachnikov, Igor

    2014-05-01

    In this work we study the dominant circulation patterns in the Subtropical Northeast Atlantic using ARGO data [25-45o N, 5-35o W]. The data were obtained from the Coriolis operational data center (ftp://ftp.ifremer.fr) for the years 1999-2013. During this period of time in the study there were available area 376 floats with 15062 float-months of total time. The floats were launched in the depths range between 300 and 2000 m, but most of the floats were concentrated at 1000 m (2000 float-months) and 1500 m (3400 float-months). In the upper 400-m layer there were also about 1000 float-months, but their number and distribution did not allow analysis of the mean currents over the study region. For each float position Lagrangian current velocity was computed as the difference between the position when the buoy started sinking to the reference depth and the consequent position of surfacing of the float, divided by the respective time interval. This allowed reducing the noise related with sea-surface drift of the buoys during the data-transmission periods. Mean Eulerian velocity and its error were computed in each of the 2ox2o square. Whenever in a 2ox2o square more than 150 observations of the Lagrangian velocity were available, the square was split into 4 smaller 1ox1o squares, in each of which the mean Eulerian velocities and their errors were estimated. Eulerian currents at 1000 m, as well as at 1500 m depth formed an overall anticyclonic circulation pattern in the study region. The modal velocity of all buoys at 1000 m level was 4 cm/s with an error of the mean of 1.8 cm/s. The modal velocity of all buoys at 1500m was 3 cm/s with an error of the mean of 1.4 cm/s. The southwestward flows near the Madeira Island and further westwards flow along the zonal band of 25-30o N at 1500 m depth well corresponded to the extension of the deep fraction of the Mediterranean Water salt tong.

  1. Global representation of tropical cyclone-induced short-term ocean thermal changes using Argo data

    NASA Astrophysics Data System (ADS)

    Cheng, L.; Zhu, J.; Sriver, R. L.

    2015-09-01

    Argo floats are used to examine tropical cyclone (TC) induced ocean thermal changes on the global scale by comparing temperature profiles before and after TC passage. We present a footprint method that analyzes cross-track thermal responses along all storm tracks during the period 2004-2012. We combine the results into composite representations of the vertical structure of the average thermal response for two different categories: tropical storms/tropical depressions (TS/TD) and hurricanes. The two footprint composites are functions of three variables: cross-track distance, water depth and time relative to TC passage. We find that this footprint strategy captures the major features of the upper-ocean thermal response to TCs on timescales up to 20 days when compared against previous case study results using in situ measurements. On the global scale, TCs are responsible for 1.87 PW (11.05 W m-2) of heat transfer annually from the global ocean to the atmosphere during storm passage (0-3 days). Of this total, 1.05 ± 0.20 PW (4.80 ± 0.85 W m-2) is caused by TS/TD and 0.82 ± 0.21 PW (6.25 ± 1.5 W m-2) is caused by hurricanes. Our findings indicate that ocean heat loss by TCs may be a substantial missing piece of the global ocean heat budget. Changes in ocean heat content (OHC) after storm passage are estimated by analyzing the temperature anomalies during wake recovery following storm events (4-20 days after storm passage) relative to pre-storm conditions. Results indicate the global ocean experiences a 0.75 ± 0.25 PW (5.98 ± 2.1 W m-2) heat gain annually for hurricanes. In contrast, under TS/TD conditions, the ocean experiences 0.41 ± 0.21 PW (1.90 ± 0.96 W m-2) ocean heat loss, suggesting the overall oceanic thermal response is particularly sensitive to the intensity of the event. The ocean heat uptake caused by all storms during the restorative stage is 0.34 PW.

  2. Mesoscale variability of water masses in the Arabian Sea as revealed by ARGO floats

    NASA Astrophysics Data System (ADS)

    Carton, X.; L'Hegaret, P.; Baraille, R.

    2012-03-01

    By analysing ARGO float data over the last four years, a few aspects of the mesoscale variability of water masses in the Arabian Sea are described. The Red Sea Outflow Water (RSOW) is concentrated in the Southwestern Gulf of Aden, in particular when a cyclonic gyre predominates in this region. Salinities of 36.5 and temperatures of 16 °C are found in this area at depths between 600 and 1000 m. RSOW is more dilute in the eastern part of the Gulf, where intense and relatively barotropic gyres mix it with Indian ocean Central Water. RSOW is also detected along the northeastern coast of Socotra, and fragments of RSOW are found between one and three degrees of latitude north of this island. In the whole Gulf of Aden, the correlation between the deep motions of the floats and the sea-level anomaly measured by altimetry is strong, at regional scale. The finer scale details of the float trajectories are not sampled by altimetry and are often related to the anomalous water masses that the floats encounter. The Persian Gulf Water (PGW) is found in the float profiles near Ras ash Sharbatat (near 57° E, 18° N), again with 36.5 in salinity and about 18-19 °C in temperature. These observations were achieved in winter when the southwestward monsoon currents can advect PGW along the South Arabian coast. Fragments of PGW were also observed in the Arabian Sea between 18 and 20° N and 63 and 65° E in summer, showing that this water mass can escape the Gulf of Oman southeastward, during that season. Kinetic energy distributions of floats with respect to distance or angle share common features between the two regions (Gulf of Aden and Arabian Sea), in particular peaks at 30, 50 and 150 km scales and along the axis of monsoon currents. Hydrological measurements by floats are also influenced by the seasonal variations of PGW and RSOW in these regions.

  3. Lower Cretaceous smarl turbidites of the Argo Abyssal Plain, Indian Ocean

    USGS Publications Warehouse

    Dumoulin, Julie A.

    1992-01-01

    Sediments recovered during Ocean Drilling Program (ODP) Leg 123 from the Argo Abyssal Plain (AAP) consist largely of turbidites derived from the adjacent Australian continental margin. The oldest abundant turbidites are Valanginian-Aptian in age and have a mixed (smarl) composition; they contain subequal amounts of calcareous and siliceous biogenic components, as well as clay and lesser quartz. Most are thin-bedded, fine sand to mud-sized, and best described by Stow and Piper's model (1984) for fine-grained biogenic turbidites. Thicker (to 3 m), coarser-grained (medium-to-coarse sand-sized) turbidites fit Bouma's model (1962) for sandy turbidites; these generally are base-cut-out (BCDE, BDE) sequences, with B-division parallel lamination as the dominant structure. Parallel laminae most commonly concentrate quartz and/or calcispheres vs. lithic clasts or clay, but distinctive millimeter to centimeter-thick, radiolarian-rich laminae occur in both fine and coarse-grained Valanginian-Hauterivian turbidites.AAP turbidites were derived from relatively deep parts of the continental margin (outer shelf, slope, or rise) that lay below the photic zone, but above the calcite compensation depth (CCD). Biogenic components are largely pelagic (calcispheres, foraminifers, radiolarians, nannofossils); lesser benthic foraminifers are characteristic of deep-water (abyssal to bathyal) environments. Abundant nonbiogenic components are mostly clay and clay clasts; smectite is the dominant clay species, and indicates a volcanogenic provenance, most likely the Triassic-Jurassic volcanic suite exposed along the northern Exmouth Plateau.Lower Cretaceous smarl turbidites were generated during eustatic lowstands and may have reached the abyssal plain via Swan Canyon, a submarine canyon thought to have formed during the Late Jurassic. In contrast to younger AAP turbidites, however, Lower Cretaceous turbidites are relatively fine-grained and do not contain notably older reworked fossils. Early

  4. ARGOS - III. Stellar populations in the Galactic bulge of the Milky Way

    NASA Astrophysics Data System (ADS)

    Ness, M.; Freeman, K.; Athanassoula, E.; Wylie-de-Boer, E.; Bland-Hawthorn, J.; Asplund, M.; Lewis, G. F.; Yong, D.; Lane, R. R.; Kiss, L. L.

    2013-04-01

    We present the metallicity results from the ARGOS spectroscopic survey of the Galactic bulge. Our aim is to understand the formation of the Galactic bulge: did it form via mergers, as expected from Λ cold dark matter theory, or from disc instabilities, as suggested by its boxy/peanut shape, or both? Our stars are mostly red clump giants, which have a well-defined absolute magnitude from which distances can be determined. We have obtained spectra for 28 000 stars at a spectral resolution of R = 11 000. From these spectra, we have determined stellar parameters and distances to an accuracy of <1.5 kpc. The stars in the inner Galaxy span a large range in [Fe/H], -2.8 ≤ [Fe/H] ≤ +0.6. From the spatial distribution of the red clump stars as a function of [Fe/H], we propose that the stars with [Fe/H] > -0.5 are part of the boxy/peanut bar/bulge. We associate the lower metallicity stars ([Fe/H] < -0.5) with the thick disc, which may be puffed up in the inner region, and with the inner regions of the metal-weak thick disc and inner halo. For the bulge stars with [Fe/H] > -0.5, we find two discrete populations: (i) stars with [Fe/H] ≈ -0.25 which provide a roughly constant fraction of the stars in the latitude interval b = -5° to -10°, and (ii) a kinematically colder, more metal-rich population with mean [Fe/H] ≈ +0.15 which is more prominent closer to the plane. The changing ratio of these components with latitude appears as a vertical abundance gradient of the bulge. We attribute both of these bulge components to instability-driven bar/bulge formation from the thin disc. We associate the thicker component with the stars of the early less metal-rich thin disc, and associate the more metal-rich population concentrated to the plane with the colder more metal-rich stars of the early thin disc, similar to the colder and younger more metal-rich stars seen in the thin disc in the solar neighbourhood today. We do not exclude a weak underlying classical merger

  5. Can we use GRACE, Argo, altimetry, and tide gauges to constrain estimates of deep ocean warming?

    NASA Astrophysics Data System (ADS)

    Leuliette, E. W.; Miller, L.; Plagge, A. M.

    2014-12-01

    Despite great progress in the coverage of ocean observing systems, two regions remain poorly monitored, the Arctic and the deep ocean below 2000 m, which is slightly over half of the ocean's volume. While significant trends in oceanic bottom water warming in recent decades can be discerned from repeat hydrographic surveys [Purkey and Johnson, 2010], they are too sparse to adequately quantify the deep ocean contribution to the present day sea level and ocean heat content budgets. However, deep ocean warming can be inferred from models or from complementary observations. Song and Colbert [2011] suggest that deep ocean warming below 700 m may have contributed 1.1 mm/yr to the global mean sea level rise (SLR), which is one-third of the rate of SLR (3.1 ± 0.6 mm/yr) observed by altimetry over 1993-2008. This estimate is considerably larger than the long-term values from earlier hydrographic studies [e.g. Levitus et al., 2005], which find a trend of 0.07 ± 0.1 mm/yr in the SLR for the depth range 700-3000 m during 1955-2003, and 0.09 ± 0.06 mm/yr below 3000 m since the 1980s. While these estimates may be biased low because of inadequate deep-ocean sampling, recent sea level budget studies also suggest that only a small rate of deep warming is necessary for closure of the budget [e.g. Leuliette and Willis, 2011; Church et al., 2011]. Using a decade of altimetry, GRACE, and Argo observations, we present an estimate of the sea level budget and explore the use of the residuals of the budget to infer recent trends in deep ocean warming. With this method we find that during January 2005 to December 2013, warming in the ocean below 2000 m is contained to < 0.2 ± 0.5 mm/yr. Crucial to constraining estimates of deep ocean warming are estimates of any drifts in the observations from the observing systems used. Here we introduce a new system to compare altimetry and tide gauge observations to estimate drifts.

  6. Using GPS data to evaluate the accuracy of state-space methods for correction of Argos satellite telemetry error.

    PubMed

    Patterson, Toey A; McConnell, Bernie J; Fedak, Mike A; Bravington, Mark V; Hindell, Mark A

    2010-01-01

    Recent studies have applied state-space models to satellite telemetry data in order to remove noise from raw location estimates and infer the true tracks of animals. However, while the resulting tracks may appear plausible, it is difficult to determine the accuracy of the estimated positions, especially for position estimates interpolated to times between satellite locations. In this study, we use data from two gray seals (Halichoerus grypus) carrying tags that transmitted Fastloc GPS positions via Argos satellites. This combination of Service Argos data and highly accurate GPS data allowed examination of the accuracy of state-space position estimates and their uncertainty derived from satellite telemetry data. After applying a speed filter to remove aberrant satellite telemetry locations, we fit a continuous-time Kalman filter to estimate the parameters of a random walk, used Kalman smoothing to infer positions at the times of the GPS measurements, and then compared the filtered telemetry estimates with the actual GPS measurements. We investigated the effect of varying maximum speed thresholds in the speed-filtering algorithm on the root mean-square error (RMSE) estimates and used minimum RMSE as a criterion to guide the final choice of speed threshold. The optimal speed thresholds differed between the two animals (1.1 m/s and 2.5 m/s) and retained 50% and 65% of the data for each seal. However, using a speed filter of 1.1 m/s resulted in very similar RMSE for both animals. For the two seals, the RMSE of the Kalman-filtered estimates of location were 5.9 and 12.76 km, respectively, and 75% of the modeled positions had errors less than 6.25 km and 11.7 km for each seal. Confidence interval coverage was close to correct at typical levels (80-95%), although it tended to be overly generous at smaller sizes. The reliability of uncertainty estimates was also affected by the chosen speed threshold. The combination of speed and Kalman filtering allows for effective

  7. Selection of Surviving Primary Protons at 4300 m a.s.l. with the ARGO-YBJ experiment

    NASA Astrophysics Data System (ADS)

    di Sciascio, G.

    The primary proton spectrum up to 100 TeV has been investigated by balloon- and satellite-borne instruments. Above this energy range only ground-based air shower arrays can measure the cosmic ray spectrum with a technique moderately sensitive to nuclear composition. An array which exploits the full coverage approach at very high altitude can achieve an energy threshold well below the TeV region, thus allowing, in principle, the calibration of the proton content in the primary cosmic ray flux. The capability of the ARGO-YBJ experiment, located at the YangBaJing Cosmic Ray Laboratory (4300 m a.s.l., Tibet, P.R. China), in selecting the surviving primary cosmic ray protons around 100 TeV is discussed. A procedure looking for quasi-unaccompanied events with a very steep lateral distribution is also presented.

  8. The Cosmic Ray spectrum in the energy region between 1012 and 1016 eV measured by ARGO-YBJ

    NASA Astrophysics Data System (ADS)

    Montini, Paolo

    2017-03-01

    The ARGO-YBJ experiment has been in full and stable data taking at the Yangbajing cosmic ray observatory (Tibet, P.R. China, 4300 m a.s.l.) for more than five years. The detector has been designed in order to explore the Cosmic Ray (CR) spectrum in an energy range from few TeV up to several PeV. The high segmentation of the detector allows a detailed measurement of the lateral particle distribution which can be exploited on order to identify showers produced by primaries of different mass. The results of the measurement of the all-particle and proton plus helium energy spectra in the energy region between 1012 and 1016 eV are discussed.

  9. Assimilation of simulated satellite altimetric data and ARGO temperature data into a double-gyre NEMO ocean model

    NASA Astrophysics Data System (ADS)

    Yan, Yajing; Barth, Alexander; Laenen, François; Beckers, Jean-Marie

    2013-04-01

    In recent years, data assimilation, adressing the problem of producing useful analyses and forecasts given imperfect dynamical models and observations, has shown increasing interest in the atmosphere and ocean science community. The efficiency of data assimilation in improving the model prediction has been proven by numerous work. However, it is still a challenge to design operational data assimilation schemes which can be operated with realistic ocean models, with reasonable quality and at acceptable cost. In this work, several experiments, assimilating the simulated altimetry and temperature observations into a double-gyre NEMO ocean model, are performed with objective to investigate the impact of different assimilation setups, including changing the observation distribution, the ensemble size and the localisation scale, on the quality of the analysis. The double-gyre NEMO ocean model corresponds to an idealized configuration of the NEMO model: a square and 5000-meter deep flat bottom ocean at mid latitudes (the so called square-box or SQB configuration). The main physical parameters governing the dominant characteristics of the flow are the initial stratification, the wind stress, the bottom friction and the lateral mixing parameterization. The domain extends from 24N to 44N, over 30° in longitude (60W - 30W) with 11 vertical levels between 152 m and 4613 m in depth. The minimum horizontal resolution of the model is 1/4°. The observations are generated from the model simulations (the truth) by adding spatially uncorrelated gaussian noise with given standard deviation. Two types of observation are considered : sea surface height (SSH) and temperature. The observation grid of the SSH is simulated from the ENVISAT and Jason-1 satellite tracks, and that of the temperature is generated in order to mimic the ARGO float profile. The observation localisation is performed in order to avoid spurious correlation at large distance. For this, the observations are weighted

  10. Revision of deposition and weathering parameters for the ingestion dose module (ECOSYS) of the ARGOS and RODOS decision support systems.

    PubMed

    Andersson, Kasper G; Nielsen, Sven P; Thørring, Håvard; Hansen, Hanne S; Joensen, Hans Pauli; Isaksson, Mats; Kostiainen, Eila; Suolanen, Vesa; Pálsson, Sigurdur Emil

    2011-11-01

    The ECOSYS model is the ingestion dose model integrated in the ARGOS and RODOS decision support systems for nuclear emergency management. The parameters used in this model have however not been updated in recent years, where the level of knowledge on various environmental processes has increased considerably. A Nordic work group has carried out a series of evaluations of the general validity of current ECOSYS default parameters. This paper specifically discusses the parameter revisions required with respect to the modelling of deposition and natural weathering of contaminants on agricultural crops, to enable the trustworthy prognostic modelling that is essential to ensure justification and optimisation of countermeasure strategies. New modelling approaches are outlined, since it was found that current ECOSYS approaches for deposition and natural weathering could lead to large prognostic errors.

  11. Prevalence and molecular identification of the sinus worm Skrjabingylus petrowi (Nematoda: Metastrongyloidea) from Martes spp. in Germany.

    PubMed

    Heddergott, M; Müller, F; Frantz, A C

    2015-06-01

    The nematodes of the genus Skrjabingylus (family Metastrongylidae) can parasitise the nasal and frontal sinus cavities of different carnivore species. Until recently, Skrjabingylus petrowi Bageanov & Petrov, 1941, has mainly been described in pine martens (Martes martes Linnaeus, 1758) and sables (Martes zibellina Linnaeus, 1758) sampled in the European part of the former Soviet Union. Newer finds in the stone marten (Martes foina Erxleben, 1777) and from different parts of Europe suggest, however, that the species might have a broader host-species range than previously assumed and be geographically more widespread as well. Since most S. petrowi records have resulted from chance discoveries rather than systematic surveys, very little is known about the prevalence of S. petrowi in marten populations. Here, we report results of a 20-year extensive survey of fresh marten skulls, where we tested 1.059 marten carcasses originating from 248 localities in Germany for the presence of S. petrowi. We identified an infestation in only four M. martes individuals and one M. foina, despite using a reliable identification method. Based on the spicule lengths of the male nematodes, the parasites were identified as S. petrowi and genetic barcoding confirmed the identification of the samples. In a phylogenetic analysis, S. petrowi and Skrjabingylus nasicola (Leuckart, 1842), formed a sister clade to all the other members of the family Metastrongylidae. The low prevalence of S. petrowi is possibly due to its parasitising in the two marten species that are either not very common (M. martes) or predominantly live in urban habitat (M. foina).

  12. A statistical study on the subthermocline submesoscale eddies in the northwestern Pacific Ocean based on Argo data

    NASA Astrophysics Data System (ADS)

    Li, Cheng; Zhang, Zhiwei; Zhao, Wei; Tian, Jiwei

    2017-05-01

    In this study, statistical characteristics and spatiotemporal variability of the cold-core subthermocline eddies (STEs) discovered by Zhang et al. (2015) in the northwestern Pacific are investigated with 14 years of Argo temperature/salinity (T/S) data between 2002 and 2015. By applying an objective identification procedure to Argo T/S profiles, a total of 337 lens-like STEs that trap cold and fresh homogeneous water are obtained. The STEs' cores are primarily located between 26.5 and 26.9σ0 (300-800 m) and their shapes share a uniform Gaussian structure in vertical. Vertical and horizontal scale of the STEs is generally between 100 and 200 m and 5 and 15 km, respectively, suggesting that they are in the category of submesoscale processes. According to their different densities and seasonalities, the STEs are classified into upper and lower types with density interface of 26.7σ0. The number of upper-type STEs is much larger in spring and summer than in autumn and winter while that of lower-type ones show relatively uniform seasonal distributions. Spatially, the STEs are primarily distributed within the region between the Kuroshio Extension (KE) and subarctic front (SAF) in meridional and 140°E-155°E in zonal direction. Based on STEs' spatial distributions and vertical locations, we propose to name these STEs as KE intermediate-layer eddies (Kiddies). Water property analysis suggests that the Kiddies most likely originated from the SAF region. For the upper-type Kiddies, they are probably generated through subduction associated with mixed-layer frontogenesis, which at least contribute to 0.25 Sv annual subduction rate for the layers 26.2-26.7σ0.

  13. Detailed temperature-salinity distribution in the Northeast Atlantic from ship and ARGO vertical casts

    NASA Astrophysics Data System (ADS)

    Neves, Filipe; Bashmachnikov, Igor; Nascimento, Angela; Medeiros, Joana; Dias, Joaquim; Ambar, Isabel; Carton, Xavier

    2014-05-01

    A new and detailed climatology (MEDTRANS) of climatic temperature-salinity distributions of ocean characteristics in the Subtropical Northeast Atlantic (25 - 45oN and 6 - 35oW) was obtained with 25-m depth interval and 30-km horizontal resolution. Having a special focus on the propagation of the Mediterranean Water (MW), this study was felt necessary since the existing global climatic fields (World Ocean Atlas 2009; Schmidtko et al., 2013; Troupin et al., 2010) do not provide sufficiently detailed or sufficiently reliable mapping at the intermediate water levels. This is particularly critical for mapping of the MW spreading near the Iberian Peninsula. The main source of the data is the World Ocean Database freely provided by the National Oceanographic Data Center (http://www.nodc.noaa.gov/). The data cover the period from 1950 to 2012 and include OSD (bottle, XCTD, low-resolution CTD casts), CTD (high-resolution CTD casts) and PFL (mainly ARGO float casts) instrument types. All data underwent a rigorous quality control, as well as preliminary filtering for the instrumental and eddy related noise. The gridding is performed along 53 neutral density surfaces (Jackett and McDougall, 1997) using Barnes' Optimum Interpolation technique (Barnes, 1964). Following the data density distribution, the radius of the Gaussian gridding function decreases towards the Iberian coast. The shape of the gridding function takes into account the influence of bottom topography on the characteristics of oceanic flows. The results are further interpolated into fixed depth levels down to 2000 m depth. The results suggest that the MEDTRANS climatology brings significantly more details of the distribution of the temperature-salinity structures related to the MW spreading in the Atlantic, of the southeastward penetration of the subpolar/polar water along the eastern slope of the Azores plateau and the King's trough/rise, and of the northwards penetration of the Antarctic Intermediate Water

  14. BioMart Central Portal--unified access to biological data.

    PubMed

    Haider, Syed; Ballester, Benoit; Smedley, Damian; Zhang, Junjun; Rice, Peter; Kasprzyk, Arek

    2009-07-01

    BioMart Central Portal (www.biomart.org) offers a one-stop shop solution to access a wide array of biological databases. These include major biomolecular sequence, pathway and annotation databases such as Ensembl, Uniprot, Reactome, HGNC, Wormbase and PRIDE; for a complete list, visit, http://www.biomart.org/biomart/martview. Moreover, the web server features seamless data federation making cross querying of these data sources in a user friendly and unified way. The web server not only provides access through a web interface (MartView), it also supports programmatic access through a Perl API as well as RESTful and SOAP oriented web services. The website is free and open to all users and there is no login requirement.

  15. Ionizing radiation affects human MART-1 melanoma antigen processing and presentation by dendritic cells.

    PubMed

    Liao, Yu-Pei; Wang, Chun-Chieh; Butterfield, Lisa H; Economou, James S; Ribas, Antoni; Meng, Wilson S; Iwamoto, Keisuke S; McBride, William H

    2004-08-15

    Radiation is generally considered to be an immunosuppressive agent that acts by killing radiosensitive lymphocytes. In this study, we demonstrate the noncytotoxic effects of ionizing radiation on MHC class I Ag presentation by bone marrow-derived dendritic cells (DCs) that have divergent consequences depending upon whether peptides are endogenously processed and loaded onto MHC class I molecules or are added exogenously. The endogenous pathway was examined using C57BL/6 murine DCs transduced with adenovirus to express the human melanoma/melanocyte Ag recognized by T cells (AdVMART1). Prior irradiation abrogated the ability of AdVMART1-transduced DCs to induce MART-1-specific T cell responses following their injection into mice. The ability of these same DCs to generate protective immunity against B16 melanoma, which expresses murine MART-1, was also abrogated by radiation. Failure of AdVMART1-transduced DCs to generate antitumor immunity following irradiation was not due to cytotoxicity or to radiation-induced block in DC maturation or loss in expression of MHC class I or costimulatory molecules. Expression of some of these molecules was affected, but because irradiation actually enhanced the ability of DCs to generate lymphocyte responses to the peptide MART-1(27-35) that is immunodominant in the context of HLA-A2.1, they were unlikely to be critical. The increase in lymphocyte reactivity generated by irradiated DCs pulsed with MART-1(27-35) also protected mice against growth of B16-A2/K(b) tumors in HLA-A2.1/K(b) transgenic mice. Taken together, these results suggest that radiation modulates MHC class I-mediated antitumor immunity by functionally affecting DC Ag presentation pathways.

  16. Molecular evidence for the presence of Dirofilaria repens in beech marten (Martes foina) from Slovakia.

    PubMed

    Miterpáková, M; Hurníková, Z; Zaleśny, G; Chovancová, B

    2013-09-23

    Herein we present the first finding of Dirofilaria repens, agent of the subcutaneous form of dirofilariosis, in Martes foina. Molecular analyses from the spleen of 3 individuals originated from Tatra National Park, Northern Slovakia, confirmed the presence of D. repens in one of them. Finding of D. repens in beech marten instigates to more intense research on free living carnivores as the potential source of Dirofilaria parasites.

  17. The antibody response against MART-1 differs in patients with melanoma-associated leucoderma and vitiligo.

    PubMed

    Teulings, Hansje-Eva; Willemsen, Karin J; Glykofridis, Iris; Krebbers, Gabrielle; Komen, Lisa; Kroon, Marije W; Kemp, E Helen; Wolkerstorfer, Albert; van der Veen, J P Wietze; Luiten, Rosalie M; Tjin, Esther P M

    2014-11-01

    Patients with melanoma may develop skin depigmentation spontaneously or following therapy, referred to as melanoma-associated leucoderma (MAL). As clinical presentation of MAL may precede primary/metastatic melanoma detection, recognition of MAL is important to prevent its misdiagnosis as vitiligo and the subsequent application of immunosuppressive treatment. To reveal the immunity involved in MAL development, we investigated the presence of antibody and T-cell immune responses directed against the melanocyte-differentiation-antigens MART-1 (Melan-A), tyrosinase and gp100 in patients with MAL, as compared to patients with vitiligo. Autoantibodies to gp100 and tyrosinase were commonly found in both diseases. Interestingly, MART-1 antibodies were only present in patients with MAL. Melanocyte antigen-specific T cells were found in all patients, with relatively more specific T cells in patients with active vitiligo. Although MAL and vitiligo may appear clinically similar, our results indicate that the humoral immune responses against MART-1 differ between these diseases, which can help to differentiate MAL from vitiligo.

  18. Ensembl BioMarts: a hub for data retrieval across taxonomic space.

    PubMed

    Kinsella, Rhoda J; Kähäri, Andreas; Haider, Syed; Zamora, Jorge; Proctor, Glenn; Spudich, Giulietta; Almeida-King, Jeff; Staines, Daniel; Derwent, Paul; Kerhornou, Arnaud; Kersey, Paul; Flicek, Paul

    2011-01-01

    For a number of years the BioMart data warehousing system has proven to be a valuable resource for scientists seeking a fast and versatile means of accessing the growing volume of genomic data provided by the Ensembl project. The launch of the Ensembl Genomes project in 2009 complemented the Ensembl project by utilizing the same visualization, interactive and programming tools to provide users with a means for accessing genome data from a further five domains: protists, bacteria, metazoa, plants and fungi. The Ensembl and Ensembl Genomes BioMarts provide a point of access to the high-quality gene annotation, variation data, functional and regulatory annotation and evolutionary relationships from genomes spanning the taxonomic space. This article aims to give a comprehensive overview of the Ensembl and Ensembl Genomes BioMarts as well as some useful examples and a description of current data content and future objectives. Database URLs: http://www.ensembl.org/biomart/martview/; http://metazoa.ensembl.org/biomart/martview/; http://plants.ensembl.org/biomart/martview/; http://protists.ensembl.org/biomart/martview/; http://fungi.ensembl.org/biomart/martview/; http://bacteria.ensembl.org/biomart/martview/.

  19. Spatio-temporal evolution of chlorophyll-a in the Bay of Bengal: a remote sensing and bio-argo perspective

    NASA Astrophysics Data System (ADS)

    Udaya Bhaskar, T. V. S.; Jayaram, Chiranjivi; Rama Rao, E. P.; Rao, K. H.

    2016-05-01

    Argo floats equipped with sensors to measure Dissolved Oxygen, Chlorophyll-a and backscattering are deployed in the Arabian Sea, Bay of Bengal and Southern Indian Ocean as part of Indian Argo program. In this study, abnormal chlorophyll-a bloom observed by a float with WMO ID 2902086 deployed in the south central Bay of Bengal is analyzed. High concentration of chlorophyll > 0.8 mg/l is observed during December 2013. This period is also associated with drop in temperature and increase in salinity. Analysis of data from the bio-Argo float has shown the impact of many cyclones and depressions that occurred during the period. Of particular importance is cyclone `Madi', which passed very near to the position of mentioned float, during December 2013. This is also evident from the satellite based wind observations from OSCAT through curl of wind stress and Ekman pumping. The sub-surface chlorophyll bloom is substantiated by the surface chlorophyll-a values of MODIS during the period. Intense mixing caused due to the passage of cyclone might have resulted in mixing of subsurface waters thereby breaking the stratification of otherwise stable surface waters of Bay of Bengal, enhancing the nutrient supply, which resulted in strong chlorophyll bloom. The subsurface chlorophyll structure of Bay of Bengal and its variability during the passage of cyclone is for the first time revealed by the floats equipped with biological sensors. This work reveals the synergistic application of in-situ (Bio- Argo) and satellite data to monitor the changes in subsurface structure during the passage of cyclones.

  20. Project ARGO: The design and analysis of an all-propulsive and an aeroassisted version of a manned space transportation vehicle

    NASA Technical Reports Server (NTRS)

    Wang, H.; Seifert, D.; Waidelich, J.; Mileski, M.; Herr, D.; Wilks, M.; Law, G.; Folz, A.

    1989-01-01

    The Senior Aerospace System Design class at the University of Michigan undertook the design of a manned space transportation vehicle (STV) that would transport payloads between low earth orbit (LEO) and geosynchronous earth orbit (GEO). Designated ARGO after the ship of the Greek adventurer Jason, two different versions of an STV that would be based, refueled, and serviced at the Space Station Freedom were designed and analyzed by the class. With the same 2-man/7-day nominal mission of transporting a 10,000-kg payload up to GEO and bringing a 5000-kg payload back to LEO, the two versions of ARGO differ in the manner in which the delta V is applied to insert the vehicle into LEO upon return from GEO. The all-propulsive ARGO (or CSTV for chemical STV) uses thrust from its LH2/LOX rocket engines to produce the delta V during all phases of its mission. While the aeroassisted ARGO (or ASTV for aeroassisted STV) also uses the same engines for the majority of the mission, the final delta V used to insert the ASTV into LEO is produced by skimming the Earth's atmosphere and using the drag on the vehicle to apply the required delta V. This procedure allows for large propellant, and thus cost, savings, but creates many design problems such as the high heating rates and decelerations experienced by a vehicle moving through the atmosphere at hypersonic velocities. The design class, consisting of 43 senior aerospace engineering students, was divided into one managerial and eight technical groups. The technical groups consisted of spacecraft configuration and integration, mission analysis, atmospheric flight, propulsion, power and communications, life support and human factors, logistics and support, and systems analysis. Two committees were set up with members from each group to create the scale models of the STV's and to produce the final report.

  1. Project ARGO: The design and analysis of an all-propulsive and an aeroassisted version of a manned space transportation vehicle

    NASA Technical Reports Server (NTRS)

    Wang, H.; Seifert, D.; Waidelich, J.; Mileski, M.; Herr, D.; Wilks, M.; Law, G.; Folz, A.

    1989-01-01

    The Senior Aerospace System Design class at the University of Michigan undertook the design of a manned space transportation vehicle (STV) that would transport payloads between low earth orbit (LEO) and geosynchronous earth orbit (GEO). Designated ARGO after the ship of the Greek adventurer Jason, two different versions of an STV that would be based, refueled, and serviced at the Space Station Freedom were designed and analyzed by the class. With the same 2-man/7-day nominal mission of transporting a 10,000-kg payload up to GEO and bringing a 5000-kg payload back to LEO, the two versions of ARGO differ in the manner in which the delta V is applied to insert the vehicle into LEO upon return from GEO. The all-propulsive ARGO (or CSTV for chemical STV) uses thrust from its LH2/LOX rocket engines to produce the delta V during all phases of its mission. While the aeroassisted ARGO (or ASTV for aeroassisted STV) also uses the same engines for the majority of the mission, the final delta V used to insert the ASTV into LEO is produced by skimming the Earth's atmosphere and using the drag on the vehicle to apply the required delta V. This procedure allows for large propellant, and thus cost, savings, but creates many design problems such as the high heating rates and decelerations experienced by a vehicle moving through the atmosphere at hypersonic velocities. The design class, consisting of 43 senior aerospace engineering students, was divided into one managerial and eight technical groups. The technical groups consisted of spacecraft configuration and integration, mission analysis, atmospheric flight, propulsion, power and communications, life support and human factors, logistics and support, and systems analysis. Two committees were set up with members from each group to create the scale models of the STV's and to produce the final report.

  2. MART-10 represses cholangiocarcinoma cell growth and high vitamin D receptor expression indicates better prognosis for cholangiocarcinoma

    PubMed Central

    Chiang, Kun-Chun; Yeh, Ta-Sen; Huang, Cheng-Cheng; Chang, Yu-Chan; Juang, Horng-Heng; Cheng, Chi-Tung; Pang, Jong-Hwei S.; Hsu, Jun-Te; Takano, Masashi; Chen, Tai C.; Kittaka, Atsushi; Hsiao, Michael; Yeh, Chun-Nan

    2017-01-01

    Cholangiocarcinoma (CCA) is a devastating disease due to no effective treatments available. Since the non-mineral functions of vitamin D emerges, 1α,25(OH)2D3, the active form of vitamin D, has been applied in anti-cancer researches. In this study, we demonstrated that both the 1α,25(OH)2D3 analog, MART-10, and 1α,25(OH)2D3 possessed anti-growth effect on human CCA cells with MART-10 much more potent than 1α,25(OH)2D3. The growth inhibition of both drugs were mediated by induction of G0/G1 cell cycle arrest through upregulation of p27 and downregulation of CDK4, CDK6, and cyclin D3. Human neutrophil gelatinase associated lipocalin (NGAL) was found to be involved in 1α,25(OH)2D3 and MART-10 meditated growth inhibition for CCA as knockdown of NGAL decreased Ki-67 expression in SNU308 cells and rendered SNU308 cells less responsive to 1α,25(OH)2D3 and MART-10 treatment. Vitamin D receptor (VDR) knockdown partly abolished MART-10-induced inhibition of NGAL and cell growth in SNU308 cells. The xenograft animal study demonstrated MART-10 could effectively repressed CCA growth in vivo without inducing obvious side effects. The IHC examination of human CCA specimen for VDR revealed that higher VDR expression was linked with better prognosis. Collectively, our results suggest that MART-10 could be a promising regimen for CCA treatment. PMID:28256614

  3. Influence of the Qinghai-Tibetan railway on the habitat selection of wild animals, using satellite data and satellite-based ARGOS system data

    NASA Astrophysics Data System (ADS)

    Buhe, Aosier

    The Qinghai-Tibet Railway (QTR) was in trial operation since 1 July 2006, is the world's highest-elevation railway and the longest highland railway, extending over 1956 km from Xining (Qinghai's capital in northwestern China) to Lhasa, the capital city of the Tibet Autonomous Region. This QTR railway was crosses five nature reserves along the route Hoh Xil (COCOX- ILI), Qinghai Sanjiangyuan, Chang Tang, Lin-chou Pengbo, and La-lu, and Hoh xil nature reserve is the important breeding sites of Tibetan Antelope (Pantholops hodgsoni). In order to clearly the habitat use and habitat selection of the Tibetan Antelope was divided in the north and south by the QTR railway, we planned the capture of ten Tibetan Antelopes and attach a satellite-based ARGOS system platform transmitter terminal (PTT) to the Tibetan Antelopes. And we succeeded in the capture of two Tibetan Antelopes for the first time in the world in 2007a summer and attached an ARGOS PTT. In this study, we estimate RASTER model of habitat change, using satellite-based ARGOS PTT tracking analyst data and satellite (Terra/MODIS, Terra/ASTER, ALOS and SPOT/vegetation instrument data) land cover change data, order to clearly the spatial and temporal characteristics of wide area habitat selection of Tibetan Antelope.

  4. Can carbon export in the North Atlantic Ocean be quantified by combining bio-optical Argo observations with a simple model?

    NASA Astrophysics Data System (ADS)

    Gordon, C. M.; Kuhn, A. M.; Fennel, K.; Claustre, H.

    2016-02-01

    The yearly phytoplankton spring bloom in the North Atlantic Ocean provides an important mechanism for carbon transport to the deep ocean through sinking aggregates, but to date this transport has been difficult to measure in situ. Our hope is that emerging bio-Argo observations combined with biological models will enable quantification of carbon export, and its inter-annual variations and trends. Argo is a global array of free-drifting profiling floats that measure temperature and salinity. More recently, some floats have been equipped with bio-optical and chemical sensors. The resulting bio-optical data not only give insights into the temporal dynamics of organic matter in the upper ocean, but can also be used to optimize and validate biological models. Here we use physical and bio-optical Argo data from the North Atlantic Ocean to constrain a 1D, float-following Nutrient-Phytoplankton-Zooplankton-Detritus (NPZD) model. The model parameters are optimized with the aid of an evolutionary algorithm in order to replicate float-based chlorophyll and particulate organic matter estimates. We analyze the combined dataset and model with specific focus on carbon transport to the deep ocean and its relation to the spring bloom.

  5. MART-1 adenovirus-transduced dendritic cell immunization in a murine model of metastatic central nervous system tumor.

    PubMed

    Broder, Howard; Anderson, Andrea; Kremen, Thomas J; Odesa, Sylvia K; Liau, Linda M

    2003-01-01

    Dendritic cells (DCs) are potent antigen-presenting cells that have been shown to play a critical role in the initiation of host immune responses against tumor antigens. In this study, a recombinant adenovirus vector encoding the melanoma-associated antigen, MART-1, was used to transduce murine DCs, which were then tested for their ability to activate cytotoxic T lymphocytes (CTLs) and induce protective immunity against B16 melanoma tumor cells implanted intracranially. Genetic modifications of murine bone marrow-derived DCs to express MART-1 was achieved through the use of an E1-deficient, recombinant adenovirus vector. Sixty-two C57BL/6 mice were immunized subcutaneously with AdVMART-1-transduced DCs (n = 23), untransduced DCs (n = 17), or sterile saline (n = 22). Using the B16 murine melanoma, which naturally expresses the MART-1 antigen, all the mice were then challenged intracranially with viable, unmodified syngeneic B16 tumor cells 7 days later. Splenocytes from representative animals in each group were harvested for standard cytotoxicity (CTL) and enzyme-linked immunospot (ELISPOT) assays. The remaining mice were followed for survival. Immunization of C57BL/6 mice with DCs transduced with an adenoviral vector encoding the MART-1 antigen elicited the development of antigen-specific CTL responses. As evidenced by a prolonged survival curve when compared to control-immunized mice with intracranial B16 tumors, AdMART-1-DC vaccination was able to elicit partial protection against central nervous system tumor challenge in vivo.

  6. Quantity and quality of drainage from the Argo Tunnel and other sources related to metal mining in Gilpin, Clear Creek and Park Counties, Colorado

    USGS Publications Warehouse

    Wentz, Dennis A.

    1977-01-01

    Eighteen metal-mine drainage sources have been located in that part of Gilpin, Clear Creek, and Park Counties, Colo., lying within the Missouri River basin. At least 13 of these sources are known to contain high acidity and (or) trace-element concentrations or to contribute water to adversely affected streams. From January 1976 to March 1977, drainage from the Argo Tunnel in Idaho Springs--one of the major metal-mine drainage sources in the study area--exhibited variations in discharge from 0.35 to 0.55 cubic feet per second (0.010 to 0.016 cubic meters per second), a relatively constant temperature of 16 degrees Celsius, and variations in specific conductance from 2,680 to 3,410 micromhos per centimeter at 25 degrees Celsius (though a value of about 3,100 micromhos persisted throughout most of the period of record). High, but relatively constant, total concentrations (in micrograms per liter) of arsenic (100 to 180), cadmium (140 to 170), copper (5,000 to 6,000), iron (160,000 to 200,000), lead (less than 100 to 200), manganese (80,000 to 110,000), and zinc (40,000 to 49,000) were measured in the Argo Tunnel drainage from March 1976 to March 1977. Except for lead, the trace elements were mostly dissolved (82 percent or greater) and appear to represent baseline concentrations. Long-term degradation of water flowing from the Argo Tunnel is shown by increases of at least 2.5 to 8.0 times for dissolved solids, dissolved iron, calcium, magnesium, and sulfate since 1906. The acidity has changed from neutral in 1906 to a median pH value of 2.9 in 1976-77. Comparison of current Argo Tunnel data with those collected previously by other investigators indicates that spring chemical flushes containing higher than baseline trace-element concentrations occurred in 1973 and 1974, but not in 1975 or 1976, and probably not in 1972. The spring chemical flushes appear to be associated with increased infiltration from snowmelt in the catchment of the Argo Tunnel. Because of the wide

  7. Conservation genetics of the genus Martes: Assessing within-species movements, units to conserve, and connectivity across ecological and evolutionary time [Chapter 17

    Treesearch

    Michael K. Schwartz; Aritz Ruiz-Gonzalez; Ryuchi Masuda; Cino Pertoldi

    2012-01-01

    Understanding the physical and temporal factors that structure Martes populations is essential to the conservation and management of the 8 recognized Martes species. Recently, advances in 3 distinct subdisciplines in molecular ecology have provided insights into historical and contemporary environmental factors that have created population substructure and influenced...

  8. MART-1- and gp100-expressing and -non-expressing melanoma cells are equally proliferative in tumors and clonogenic in vitro.

    PubMed

    Aris, Mariana; Zubieta, Mariana Rodríguez; Colombo, Marina; Arriaga, Juan Martín; Bianchini, Michele; Alperovich, Myriam; Bravo, Alicia I; Barrio, María M; Mordoh, José

    2012-02-01

    MART-1 and gp100 are prototypical melanoma antigen (Ag), but their clinical use as vaccines or as targets of cytotoxic lymphocytes achieved modest success. Possible explanations could be that as MART-1 and gp100 are melanocyte differentiation Ag, clonogenic Ag-non-expressing cells would be spared by immune effectors, or that clonogenic cells would be intrinsically resistant to cytotoxic lymphocytes. We therefore analyzed the proliferative status of MART-1/gp100-expressing and -non-expressing cells in biopsies, and the clonogenicity and sensitiveness to cytotoxic lymphocytes of the human cutaneous melanoma cell lines MEL-XY1 and MEL-XY3. Analysis of MART-1/gp100 and Ki-67 expression in 22 melanoma tumors revealed that MART-1/gp100-expressing and -non-expressing cells proliferated competitively. MART-1, gp100, tyrosinase, and CD271 expression were studied in MEL-XY1 and MEL-XY3 colonies. At 7 days, colonies displayed positive, negative, and mixed expression patterns. By 14 days, colonies of different sizes developed, showing cells with different clonogenic potential, and Ag were downregulated, suggesting Ag plasticity. Subcloning of MEL-XY1 colonies showed that Ag expression varied with time without interfering with clonogenicity. Finally, clonogenic, MART-1/gp100-expressing cells were lysed by specific CD8 lymphocytes. Thus, MART-1 and gp100 expression and plasticity would not interfere with proliferation or clonogenicity, and clonogenic cells may be lysed by cytotoxic lymphocytes.

  9. Parasitological and molecular features of the Hepatozoon species in the myocardium of Japanese Martens (Martes melampus melampus).

    PubMed

    Kubo, Masahito; Nagataki, Mitsuru; Agatsuma, Takeshi; Sakai, Hiroki; Masegi, Toshiaki; Panciera, Roger J; Yanai, Tokuma

    2009-12-01

    The Hepatozoon species in the myocardium of Japanese martens (Martes melampus melampus) was characterized by histological and molecular methods. Histologically, granulomatous nodules with Hepatozoon sp. merozoites/gametocytes, or schizonts, or both were observed in the hearts of Japanese martens. The most frequently observed forms were merozoites/gametocytes within phagocytes; each host cell included a zoite, which was not microscopically identifiable as a merozoite or gametocyte. Schizonts were oval in shape and 36.9 ± 5.7 x 28.9 ± 3.4 μm in size; each schizont had approximately 20-60 nuclei. The size of the merozoites could not be measured because no mature schizonts were observed. In the analyses of the partial 18S rRNA gene sequence, it was strongly suggested that the Hepatozoon sp. in Japanese marten and the Hepatozoon sp. in pine marten (Martes martes) in Scotland were the same species.

  10. Quality Controlled Argo Profiling Float Oxygen Data: Open Source Sharing and Version Control Using IPython Notebooks on GitHub

    NASA Astrophysics Data System (ADS)

    Sakamoto, C.; McCann, M. P.; Plant, J. N.; Johnson, K. S.

    2015-12-01

    Profiling floats equipped with biogeochemical sensors are an ideal platform for observing the seasonal evolution of physical and chemical processes from the surface to the deep interior. As of August 2015, there have reportedly been 765 floats equipped with oxygen sensors with 363 currently active. Although new insights into oceanic biogeochemical processes have come from these data, the profiling oxygen data set has not been fully utilized because the dissolved oxygen data does not undergo QC procedures at the Argo data centers. The oxygen sensors on profiling floats have been demonstrated to produce highly stable and precise data over many months and years but only a small percentage have been verified with discrete samples taken at deployment to determine the sensor accuracy. Takeshita et al (2013) presented a climatology based quality control procedure utilizing the World Ocean Atlas 2009 (WOA09). We used a straightforward approach mentioned in their paper to calculate the sensor gain by comparing the surface %Sat(float) to the surface %Sat(WOA09) using > 1 year of data. We have developed Python scripts to provide QC'd data that are freely available and easily shared using IPython Notebooks hosted on GitHub. We will examine the consistency of the corrected oxygen data set, relative to existing climatologies, and its use in oceanographic studies.

  11. Exclusive Muon-Neutrino Charged Current Muon Plus Any Number of Protons Topologies In ArgoNeuT

    SciTech Connect

    Partyka, Kinga Anna

    2013-01-01

    Neutrinos remain among the least understood fundamental particles even after decades of study. As we enter the precision era o f neutrino measurements bigger and more sophisticated detectors have emerged. The leading candidate among them is a Liquid Argon Time Projection Chamber (LArTPC ) detector technology due to its bubble-like chamber imaging, superb background rejection and scalability. I t is a perfect candidate that w ill aim to answer the remaining questions of the nature o f neutrino and perhaps our existence. Studying neutrinos with a detector that employs detection via beautiful images o f neutrino interactions can be both illuminating and surprising. The analysis presented here takes the full advantage of the LArTPC power by exploiting the first topological analysis of charged current muon neutrino p + N p , muon and any number of protons, interactions with the ArgoNeuT LArTPC experiment on an argon target. The results presented here are the first that address the proton multiplicity at the vertex and the proton kinematics. This study also addresses the importance o f nuclear effects in neutrino interactions. Furthermore, the developed here reconstruction techniques present a significant step forward for this technology and can be employed in the future LArTPC detectors.

  12. Observations of upper ocean stability and heat fluxes in the Antarctic from under-ice Argo float profile data.

    NASA Astrophysics Data System (ADS)

    Wilson, E. A.; Riser, S.

    2016-12-01

    Sea ice growth around Antarctica is intimately linked to the stability and thermohaline structure of the underlying ocean. As sea ice grows, the resulting brine triggers convective instabilities that deepen the mixed layer and entrain warm water from the weakly stratified pycnocline. The heat released from this process acts as a strong negative feedback to ice growth which, under the right scenarios, can exceed the initial atmospheric heat loss. Much of our current understanding of this ice-ocean interaction comes from a handful of relatively short field campaigns in the Weddell Sea. Here, we supplement those observations with an analysis of over 9000 under-ice Argo float profiles, collected between 2006-2015. These profiles provide an unprecedented view of the temporal and spatial variability of the upper ocean structure throughout the Antarctic region. With these observations and a theoretical understanding of the coupled ice-ocean system, we assess the ocean's potential to limit thermodynamic ice growth as well as its susceptibility to deep convection in different regions. Using these results, we infer how recent climatic changes may influence Antarctic sea ice growth and deep ocean ventilation in the near future.

  13. Hydrocarbon potential, organic matter diagenesis, sedimentology, and paleoenvironment of upper Mesozoic dark shales, northern Himalayas and Argo abyssal plain

    SciTech Connect

    Thurow, J.; Gibling, M.

    1989-03-01

    The Late Jurassic was a time favorable for the deposition of black shale-type sediments in shallow environments as known from circum-North Atlantic basins, North Sea, and Himalayan Tethys regions. Locally these shales have excellent hydrocarbon source potential. The site of the Spiti shales in the Thakkola region of north-central Nepal provides the opportunity to study a long-term (Oxfordian-Tithonian) stable, shallow, and oxygen-depleted environment. Strata with calcareous benthic communities show that the environment was not anoxic. Organic geochemical and sedimentological analyses on the Spiti shales (Oxfordian-Valanginian) were done to understand the hydrocarbon potential, organic matter diagenesis, sedimentology, and paleoenvironment of this sequence. The depositional environment changed, driven by tectono-eustatic and climatic events, from an open shelf (approximately 250 m) with low amounts of detrital input and rich macrofossil communities to an extremely shallow, partly continental environment with intercalations of quartzose channel fill, silty shales, rare lumachelle layers, and coal seams. Paleocurrents suggest a north-facing continental margin bordering the Tethys Sea. The organic matter changed from marine (Jurassic) to terrestrial in the Cretaceous. Analysis of coeval strata, deposited in the deep-marine environment off the northern Indian shelf (contiguous with the present-day Argo abyssal plain), demonstrates the changing shallow to deep-water hydrocarbon potential. It reflects the more advanced organic matter maturation of the onshore material due to Himalayan tectonics and allows tracing the transport of the organic matter.

  14. Chemical Characterization and Cytoprotective Effect of the Hydroethanol Extract from Annona coriacea Mart. (Araticum)

    PubMed Central

    Júnior, José G. A. S.; Coutinho, Henrique D. M.; Boris, Ticiana C. C.; Cristo, Janyketchuly S.; Pereira, Nara L. F.; Figueiredo, Fernando G.; Cunha, Francisco A. B.; Aquino, Pedro E. A.; Nascimento, Polyana A. C.; Mesquita, Francisco J. C.; Moreira, Paulo H. F.; Coutinho, Sáskia T. B.; Souza, Ivon T.; Teixeira, Gabriela C.; Ferreira, Najla M. N.; Farina, Eleonora O.; Torres, Cícero M. G.; Holanda, Vanderlan N.; Pereira, Vandbergue S.; Guedes, Maria I. F.

    2016-01-01

    Introduction: Annona coriacea Mart. (araticum) is a widely distributed tree in the cerrado. Its value is attributed principally to the consumption of its fruit which possesses a large nutritive potential. The objective was to identify the chemical profile and evaluate the antimicrobial and cytoprotective activity of the hydroethanol extract of A. coriacea Mart. (HEAC) leaves against the toxicity of mercury chloride. Materials and Methods: The characterization of components was carried out using high-performance liquid chromatography (HPLC). The minimum inhibitory concentration (MIC) was determined by microdilution method in broth with strains of Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. For evaluation of the modulatory and cytoprotective activity of aminoglycoside antibiotics (gentamicin and amikacin) and mercury chloride (HgCl2), the substances were associated with the HEAC at subinhibitory concentrations (MIC/8). Results and Discussion: The HPLC analysis revealed the presence of flavonoids such as Luteolin (1.84%) and Quercetin (1.19%) in elevated concentrations. The HEAC presented an MIC ≥512 μg/mL and significant antagonistic action in aminoglycosides modulation, and it also showed cytoprotective activity to S. aureus (significance P < 0.0001) and E. coli (significance P < 0.05) bacteria against the mercury chloride heavy metal with significance, this action being attributed to the chelating properties of the flavonoids found in the chemical identification. Conclusions: The results acquired in this study show that the HEAC presents cytoprotective activity over the tested strains in vitro and can also present antagonistic effect when associated with aminoglycosides, reinforcing the necessity of taking caution when combining natural and pharmaceutical products. SUMMARY The hydroalcoholic extract of A. coriacea Mart. presents in vitro cytoprotective activity against the toxic effect of Hg. Abbreviations Used: HPLC-DAD: High

  15. Reduced recognition of metastatic melanoma cells by autologous MART-1 specific CTL: relationship to TAP expression.

    PubMed

    Murray, J L; Hudson, J M; Ross, M I; Zhang, H Z; Ioannides, C G

    2000-01-01

    Class I expression in context with T-cell receptor expression is crucial for peptide presentation and induction of CD8+ cytotoxic T lymphocytes (CTL). Presentation of class I bound peptides is dependent on transporter-associated proteins (TAP) expression and function. Tumor infiltrating lymphocytes from a patient with melanoma were isolated, expanded in vitro in the presence of interleukin-2, and tested for cytotoxicity against HLA-A2 positive, MART-1 positive autologous tumor cells, an HLA-A2-positive, MART-1 positive melanoma cell line (Mel-501), and HLA-A2-negative melanoma cells. Significant killing occurred against both A2-positive cell lines (63% and 65%, respectively), but not against the A2-negative line (18%) or A2-positive autologous tumor (1.5%). These CTL preferentially recognized the MART-1 peptide F119, 27-35, and gp100 peptide F125, 280-288, resulting in a 30% to 60% enhancement of lysis when autologous tumor or major histocompatibility complex class I "empty" T2 cells were pulsed with either peptide. To address whether the deficiency in autologous tumor recognition might be related to a deficiency in Ag presentation, we screened for the presence of TAP1 and TAP2 transcripts by polymerase chain reaction, Southern blotting, and scanning densitometry using sequence-specific primers and probes. Both TAP1 and TAP2 expression levels in the autologous tumor were minimal, yet were upregulated 7- to 18-fold, respectively, by interferon-gamma. Despite this increase, a similar increase in cytotoxicity did not occur. In short, deficiencies in TAP presentation may have functional significance for tumor escape from immunosurveillance and with respect to impending vaccine trials.

  16. [Changes in correlations between commercially valuable characters of the sable Martes zibellina L. during artificial selection].

    PubMed

    Kashtanov, S N; Labeznyĭ, O E; Imasheva, A G

    2008-11-01

    A farm population of the sable Martes zibellina L. has been selected for darker coat color during 40 years. Correlations between fitness characters and correlations of these characters with the selected character have been monitored. Correlation analysis has shown that the female fertility in the first year of reproduction is a promising predictor of how valuable the female will be for further breeding. Artificial directional selection has been shown to change the correlations that have been formed in natural populations of the sable. The relationship of this phenomenon with a decrease in the overall fitness during selection that has been observed in the sable population is discussed.

  17. Sarcocystis neurona-associated meningoencephalitis and description of intramuscular sarcocysts in a fisher (Martes pennanti).

    PubMed

    Gerhold, Richard W; Howerth, Elizabeth W; Lindsay, David S

    2005-01-01

    A free-ranging juvenile fisher (Martes pennanti) with ataxia, lethargy, stupor, and intermittent, whole-body tremors was examined postmortem. Microscopically, the fisher had protozoal meningoencephalitis caused by Sarcocystis neurona, which was confirmed by immunohistochemistry, polymerase chain reaction (PCR) and restriction fragment length polymorphism testing, and genetic sequencing. Sarcocysts found in the skeletal muscle of the fisher were negative for S. neurona by PCR, but were morphologically similar to previous light and electron microscopy descriptions of S. neurona. This is the first report of clinical neural S. neurona infection in a fisher.

  18. Complete mitochondrial genome of Korean yellow-throated marten, Martes flavigula (Carnivora, Mustelidae).

    PubMed

    Jang, Kuem Hee; Hwang, Ui Wook

    2016-05-01

    The complete mitogenome sequence of Martes flavigula, which is an endangered and endemic species in South Korea, was determined. The genome is 16,533 bp in length and its gene arrangement pattern, gene content, and gene organization is identical to those of martens. The control region was located between the tRNAPro and tRNAPhe genes and is 1087 bp in length. This mitogenome sequence data might be an important role in the preservation of genetic resources by allowing researchers to conduct phylogenetic and systematic analyses of Mustelidae.

  19. Anatomical studies on water hyacinth (Eichhornia crassipes (Mart.) Solms) under the influence of textile wastewater*

    PubMed Central

    Mahmood, Qaisar; Zheng, Ping; Siddiqi, M. Rehan; Islam, Ejaz ul; Azim, M. Rashid; Hayat, Yousaf

    2005-01-01

    Water hyacinth (Eichhornia crassipes (Mart.) Solms) is a prolific free floating aquatic macrohpyte found in tropical and subtropical parts of the earth. The effects of pollutants from textile wastewater on the anatomy of the plant were studied. Water hyacinth exhibits hydrophytic adaptations which include reduced epidermis cells lacking cuticle in most cases, presence of large air spaces (7~50 μm), reduced vascular tissue and absorbing structures. Textile waste significantly affected the size of root cells. The presence of raphide crystals was noted in parenchyma cells of various organs in treated plants. PMID:16187412

  20. [Growth of the water hyacinth (Eichhornia crassipes (Mart) Solms Laubach) in the tropics].

    PubMed

    Lareo, L

    1981-12-01

    The growth and reproduction rates of water hyacinth (Eicchornia crassipes (Mart) Solms Laubach) in tropical areas, under natural and fertilized controlled conditions, were studied. The fertilizer used was swine fecal matter at three different levels: 1.25, 2.5 and 5%. The highest rate of growth was found with the 2.5% concentration, and this value was 49.16 g/m2/day on a dry-weight basis. Under natural conditions the rate of growth was 18.39 g/m2/day on a dry-weight basis. These results represent a yearly production in ton/ha among the highest reported in the world.

  1. Francisella tularensis infection in a stone marten (Martes foina) without classic pathological lesions consistent with tularemia.

    PubMed

    Origgi, Francesco C; Wu, Natacha; Pilo, Paola

    2013-07-01

    The current report describes the isolation and typing of a strain of Francisella tularensis, the causative agent of tularemia, from the spleen of a stone marten (Martes foina) showing no classic lesions consistent with the disease. The identification of this bacterium, belonging to the World Health Organization risk 3 category and considered to have a low infectious dose, could be performed only because of an ongoing project screening F. tularensis in the environment sensu lato. The findings described herein should alert diagnostic laboratories of the possible presence of F. tularensis in clinical samples in countries where tularemia is endemic even in cases with no consistent anamnesis and from unsuspected animal species.

  2. SigReannot-mart: a query environment for expression microarray probe re-annotations

    PubMed Central

    Moreews, François; Rauffet, Gaelle; Dehais, Patrice; Klopp, Christophe

    2011-01-01

    Expression microarrays are commonly used to study transcriptomes. Most of the arrays are now based on oligo-nucleotide probes. Probe design being a tedious task, it often takes place once at the beginning of the project. The oligo set is then used for several years. During this time period, the knowledge gathered by the community on the genome and the transcriptome increases and gets more precise. Therefore re-annotating the set is essential to supply the biologists with up-to-date annotations. SigReannot-mart is a query environment populated with regularly updated annotations for different oligo sets. It stores the results of the SigReannot pipeline that has mainly been used on farm and aquaculture species. It permits easy extraction in different formats using filters. It is used to compare probe sets on different criteria, to choose the set for a given experiment to mix probe sets in order to create a new one. Database URL: http://sigreannot-mart.toulouse.inra.fr/ PMID:21930501

  3. An analysis of natural ventilation techniques to achieve indoor comfort in Wal-Mart express

    NASA Astrophysics Data System (ADS)

    O'Dea, Shona

    Despite global efforts to reduce world fossil fuel dependency the world still obtains 81% of its energy from fossil fuels (IEA,2009). Modern renewable alternatives have been around since the mid twentieth century these alternatives have not been integrated into electrical grid systems at the exponential rate required to eradicate fossil fuels dependency. The problem, world energy demand, is too large to be satisfied by anything other than the energy-dense fossil fuels used today. We must change our energy intensive processes in order to conserve energy and hence reduce the demands that alternatives must satisfy. This research aims to identify sustainable design opportunities through the application of innovative technologies for the largest retailer in the US with the view that a viable conservative design measure could be applied to the store model, which is replicated across the country, causing a cumulative and hence larger impact on the company energy consumption as a whole. This paper will present the literature available on the 'big box' industry and Wal-Mart, comfort, natural ventilation and building simulation software and then perform an analysis into the viability of naturally ventilating the Wal-Mart Express sales zone using Monodraught natural ventilation windcatcher products

  4. Analysis of bioactivities and chemical composition of Ziziphus joazeiro Mart. using HPLC-DAD.

    PubMed

    Brito, Sharlene M O; Coutinho, Henrique D M; Talvani, Andre; Coronel, Cathia; Barbosa, Andreza G R; Vega, Celeste; Figueredo, Fernando G; Tintino, Saulo R; Lima, Luciene F; Boligon, Aline A; Athayde, Margareth L; Menezes, Irwin R A

    2015-11-01

    The aim of this study was to evaluate the chemical profile and antioxidant, antimicrobial and antiparasitic activities of the hydroalcoholic extract of the leaves of Ziziphus joazeiro Mart. (HELZJ). The antioxidant DPPH and FRAP assays and chemical profile were determined by colorimetric methods and HPLC/DAD. The antiparasitic, antibiotic and antibiotic-modifying activity were evaluated by microdilution assays. The HPLC-DAD assay showed the presence of mostly tannins and flavonoids, such as caffeic acid and quercetin. The levels of polyphenols and flavonoids were 183.136 mg/g extract and 7.37 mg/g extract, respectively. DPPH and FRAP showed low antioxidant activity for the extract. The antibacterial and antifungal activities were not of clinical relevance, showing MIC>1024 μg/mL. However, synergism was observed between HELZJ and the antibiotics amikacin and gentamicin, which resulted in decreased bacterial drug resistance. EHFZJ showed low toxicity in fibroblasts in vitro, while antiparasitic results against Trypnosoma cruzi, Leishmania braziliensis and Leishmania infantum were not clinically relevant. Thus, our results indicate that Z. joazeiro Mart. (HELZJ) could be a source of plant-derived natural products that could lead to the development of promising new antibiotic compounds for infectious diseases.

  5. Search for GeV gamma-ray bursts with the ARGO-YBJ detector: summary of eight years of observations

    SciTech Connect

    Bartoli, B.; Catalanotti, S.; Piazzoli, B. D'Ettorre; Di Girolamo, T.; Bernardini, P.; D'Amone, A.; De Mitri, I.; Bi, X. J.; Cao, Z.; Chen, S. Z.; Branchini, P.; Budano, A.; Camarri, P.; Cardarelli, R.; Sciascio, G. Di; Chen, T. L.; Danzengluobu; Creti, P.; Cui, S. W.; Dai, B. Z. E-mail: Piero.Vallania@to.infn.it; Collaboration: ARGO-YBJ Collaboration; and others

    2014-10-10

    The search for gamma-ray burst (GRB) emission in the energy range of 1-100 GeV in coincidence with the satellite detection has been carried out using the Astrophysical Radiation with Ground-based Observatory at YangBaJing (ARGO-YBJ) experiment. The high-altitude location (4300 m a.s.l.), the large active surface (∼6700 m{sup 2} of Resistive Plate Chambers), the wide field of view (∼2 sr, limited only by the atmospheric absorption), and the high duty cycle (>86%) make the ARGO-YBJ experiment particularly suitable to detect short and unexpected events like GRBs. With the scaler mode technique, i.e., counting all the particles hitting the detector with no measurement of the primary energy and arrival direction, the minimum threshold of ∼1 GeV can be reached, overlapping the direct measurements carried out by satellites. During the experiment lifetime from 2004 December 17 to 2013 February 7, a total of 206 GRBs occurring within the ARGO-YBJ field of view (zenith angle θ ≤ 45°) have been analyzed. This is the largest sample of GRBs investigated with a ground-based detector. Two light curve models have been assumed and since in both cases no significant excess has been found, the corresponding fluence upper limits in the 1-100 GeV energy region have been derived, with values as low as 10{sup –5} erg cm{sup –2}. The analysis of a subset of 24 GRBs with known redshift has been used to constrain the fluence extrapolation to the GeV region together with possible cutoffs under different assumptions on the spectrum.

  6. Simulating the effects of climate change on population connectivity of American marten (Martes americana) in the northern Rocky Mountains, USA

    Treesearch

    T. N. Wasserman; S. A. Cushman; A. S. Shirk; E. L. Landguth; J. S. Littell

    2012-01-01

    We utilize empirically derived estimates of landscape resistance to assess current landscape connectivity of American marten (Martes americana) in the northern Rocky Mountains, USA, and project how a warming climate may affect landscape resistance and population connectivity in the future. We evaluate the influences of five potential future temperature scenarios...

  7. Developing and testing a landscape habitat suitability model for the American marten (Martes americana) in the Cascades mountains of California

    Treesearch

    Thomas A. Kirk; William J. Zielinski

    2009-01-01

    We used field surveys and Geographic Information System data to identify landscape-scale habitat associations of American martens (Martes americana) and to develop a model to predict their occurrence in northeastern California. Systematic surveys using primarily enclosed track plates, with 10-km spacing, were conducted across a 27,700 km

  8. Non-fermented and fermented Jabuticaba (Myrciaria cauliflora Mart.) pomaces of as valuable sources of functional ingredients

    USDA-ARS?s Scientific Manuscript database

    Jabuticaba (Myrciaria cauliflora Mart) is a non-climacteric, highly perishable fruit native to Brazil, which is consumed both fresh and industrially processed in the form of juices, jams, wines and distilled liqueurs. The processing to obtain these products generates a great amount of by-products (p...

  9. Coinfection with Hepatozoon sp. and Canine Distemper Virus in a Yellow-throated Marten ( Martes flavigula koreana) in Korea.

    PubMed

    Park, Surim; Choi, Ul Soo; Kim, Eun Ju; Lee, Jong Hyun; Lee, Hae Beom; Cho, Ho Seong; Kim, Wonil; Lim, Chae Woong; Kim, Bumseok

    2016-04-28

    We describe coinfection with Hepatozoon sp. and canine distemper virus (CDV) in a yellow-throated marten ( Martes flavigula koreana). We found Hepatozoon cysts in muscular tissue and viral inclusion bodies in the brain. Hepatozoon sp., and CDV was confirmed in blood and brain, respectively, by PCR.

  10. Antioxidant capacities and anti-inflammatory effects of flavonoid compounds isolated from acai pulp (Euterpe oleracea Mart.)

    USDA-ARS?s Scientific Manuscript database

    Acai fruit (Euterpe oleracea Mart.) has been demonstrated to exhibit extremely high antioxidant capacity. Seven major flavonoids were isolated from freeze-dried acai pulp by various chromatographic methods. Their structures were elucidated as orientin (1), homoorientin (2), vitexin (3), luteolin (4)...

  11. The Argo simulation - I. Quenching of massive galaxies at high redshift as a result of cosmological starvation

    NASA Astrophysics Data System (ADS)

    Feldmann, Robert; Mayer, Lucio

    2015-01-01

    Observations show a prevalence of high-redshift galaxies with large stellar masses and predominantly passive stellar populations. A variety of processes have been suggested that could reduce the star formation in such galaxies to observed levels, including quasar mode feedback, virial shock heating, or galactic winds driven by stellar feedback. However, the main quenching mechanisms have yet to be identified. Here we study the origin of star formation quenching using Argo, a cosmological, hydrodynamical zoom-in simulation that follows the evolution of a massive galaxy at z ≥ 2. This simulation adopts the same subgrid recipes of the Eris simulations, which have been shown to form realistic disc galaxies, and, in one version, adopts also a mass and spatial resolution identical to Eris. The resulting galaxy has properties consistent with those of observed, massive (M* ˜ 1011 M⊙) galaxies at z ˜ 2 and with abundance matching predictions. Our models do not include active galactic nuclei (AGN) feedback indicating that supermassive black holes likely play a subordinate role in determining masses and sizes of massive galaxies at high-z. The specific star formation rate (sSFR) of the simulated galaxy matches the observed M*-sSFR relation at early times. This period of smooth stellar mass growth comes to a sudden halt at z = 3.5 when the sSFR drops by almost an order of magnitude within a few hundred Myr. The suppression is initiated by a levelling off and a subsequent reduction of the cool gas accretion rate on to the galaxy, and not by feedback processes. This `cosmological starvation' occurs as the parent dark matter halo switches from a fast collapsing mode to a slow accretion mode. Additional mechanisms, such as perhaps radio mode feedback from an AGN, are needed to quench any residual star formation of the galaxy and to maintain a low sSFR until the present time.

  12. Global representation of tropical cyclone-induced ocean thermal changes using Argo data - Part 1: Methods and results

    NASA Astrophysics Data System (ADS)

    Cheng, L.; Zhu, J.; Sriver, R. L.

    2014-12-01

    Argo floats are used to examine tropical cyclone (TC)-induced ocean thermal changes on the global scale by comparing temperature profiles before and after TC passage. We present a footprint method that analyzes cross-track thermal responses along all storm tracks during the period 2004-2012. We combine the results into composite representations of the vertical structure of the average thermal response for two different categories: tropical storms/depressions (TS/TD) and hurricanes. The two footprint composites are functions of three variables: cross-track distance, water depth and time relative to TC passage. We find that this footprint strategy captures the major features of the upper-ocean thermal response to TCs on time scales up to 20 days when compared against previous case study results using in situ measurements. Further, TC effects are distinguishable from background sampling variability, but the significance of this result depends on differences in regional oceanic conditions and the intensity of the TC events. On the global scale, results indicate that hurricanes induce strong upwelling near the storm center, along with downwelling away from the storm, during the first 3 days after storm passage. We also find significant subsurface warming between 30 and 200 m depth for both hurricanes and TS/TDs. On average, the subsurface ocean response persists along storm tracks for up to 20 days down to 200 (400) m depth for TS/TD (Hurricanes), exhibiting peak warming of 0.4 °C at 60 m for hurricanes and 0.2 °C at 35 m for TS/TD. The footprint method shows a weak cooling response between 200 and 400 m, which is significant for Hurricanes but not for TS/TD.

  13. Tropical-Extratropical Exchange Based on Argo Profiles and Ship-Based Observations Near the Western Boundary

    NASA Astrophysics Data System (ADS)

    Yuan, D.; Li, B.; Yang, L.

    2014-12-01

    The tropical-extratropical exchange in the northwestern Pacific Ocean is studied using the absolute geostrophic currents based on Argo Profiles and the observations of the western boundary currents (WBCs) during two cruises in the winters of 2010 and 2012. The absolute geostrophic currents are calculated using the P-vector method for the period of 2004 through 2011. The transport of the geostrophic currents is compared with the Sverdrup theory and found to differ significantly in several locations. Analyses have shown that errors of wind stress estimation cannot account for all of the differences. The largest differences are found in the area, where nonlinear activities are vigorous. It is, therefore, suggested that the linear dynamics of the Sverdrup theory is deficient in explaining the geostrophic transport of the tropical northwestern Pacific Ocean. Previous studies suggest recharge and discharge of the tropical Pacific Ocean heat content through the interior circulation of the North Pacific Ocean, based on the Sverdrup theory, and that the WBCs play the role opposite to the interior ocean recharge and discharge anomalies. Using ocean observations from two cruises in a La Niña winter and a normal winter, it is suggested that the Kuroshio transport decreases significantly and the Mindanao Current transport increases significantly at the peak of 2010 La Niña, opposite to the prediction of existing theory. The anomalies of the western boundary current transport are found much larger than those of the meridional circulation in the entire interior of the North Pacific Ocean, the dynamics of which are suggested to be associated with the Kelvin wave propagation around the Philippine islands. The results suggest that the WBCs dominate the interannual recharge and discharge of the western Pacific warm pool during the 2010 La Niña.

  14. Global assessment of Level 3 SMOS and Aquarius salinity measurements using Argo and an operational ocean model

    NASA Astrophysics Data System (ADS)

    Banks, Chris; Gommenginger, Christine; Srokosz, Meric; Snaith, Helen

    2013-04-01

    The launch of the European Space Agency (ESA) Soil Moisture and Ocean Salinity (SMOS) satellite in November 2009 marked a new era in satellite oceanography. SMOS was joined in orbit, in June 2011, by the NASA/Argentine Aquarius/SAC-D mission, specifically designed to measure sea surface salinity (SSS). These two satellites have significantly improved our ability to measure SSS synoptically. Despite significant differences in how the two satellites estimate SSS, both utilise passive systems to measure the response of the brightness temperature (Tb) at L-band (1.4 GHz) to SSS and initial results are encouraging. The UK National Oceanography Centre has produced 'Level 3' SSS data products for SMOS and Aquarius using monthly data on a 1° by 1° global grid, between 60°S and 60°N, from 1 September 2011 to 31 August 2012. Previous and on-going work shows for both satellites significant temporally varying differences between SSS from ascending passes (satellite moving south to north) and SSS from descending passes (satellite moving north to south). Therefore, for both SMOS and Aquarius, separate Level 3 products are produced from data for ascending and descending passes. For this study, two separate monthly validation datasets are used based on the same grid as the satellite data. The first is averaged near-surface salinity (depth less than 10 m) as derived from the drifting Argo float programme. The second validation data source is output from the UK Met Office Forecasting Ocean Assimilation Model (FOAM), which is based on NEMO (Nucleus for European Modelling of the Ocean). We calculate maps of the difference between all possible pairs of SSS data for each month, and consider their relationships using regression on the 1˚ values. The analysis is carried out for the global ocean, as well as for smaller, more homogeneous, study regions (e.g. SPURS in the subtropical North Atlantic).

  15. Antarctic Circumpolar Current frontal system in the South Atlantic: Monitoring using merged Argo and animal-borne sensor data

    NASA Astrophysics Data System (ADS)

    Boehme, L.; Meredith, M. P.; Thorpe, S. E.; Biuw, M.; Fedak, M.

    2008-09-01

    We describe large-scale features of the Antarctic Circumpolar Current (ACC) in the Atlantic part of the Southern Ocean by merging Argo data and data obtained by novel animal-borne CTD sensors. Twenty one of these CTD-Satellite Relay Data Loggers (CTD-SRDLs) were attached to Southern elephant seals (Mirounga leonina) on South Georgia. The merged data yield unified gridded hydrogaphic fields with high temporal and spatial resolution, enabling the determination of features absent in each of the data sets separately. The structure and variability of the frontal field revealed by this data set were compared with those in daily quarter-degree, optimally interpolated sea surface temperature fields and fields of weekly gridded sea level anomaly. In general, the frontal positions derived using our data set are in agreement with previous work, especially where the pathways are constrained by topography, e.g., at the North Scotia Ridge and the South Scotia Ridge. However, with the improved temporal and spacial resolution provided by the CTD-SRDLs, we were able to observe some novel features. All frontal positions are more variable than previously indicated across the Scotia Sea and west of the Mid-Atlantic Ridge on seasonal time scales. The merged data set shows the temporal variability of the Southern ACC Front (SACCF) north of South Georgia and in its position east of the island, where the SACCF lies further north than has been suggested in previous work. In addition, the Subantarctic Front crosses the Mid-Atlantic Ridge about 400 km further north when compared to previous work.

  16. ARGO-YBJ OBSERVATION OF THE LARGE-SCALE COSMIC RAY ANISOTROPY DURING THE SOLAR MINIMUM BETWEEN CYCLES 23 AND 24

    SciTech Connect

    Bartoli, B.; Catalanotti, S.; Piazzoli, B. D’Ettorre; Girolamo, T. Di; Bernardini, P.; D’Amone, A.; Mitri, I. De; Bi, X. J.; Cao, Z.; Chen, S. Z.; Feng, Zhaoyang; Gou, Q. B.; Chen, T. L.; Danzengluobu; Cui, S. W.; Gao, W.; Dai, B. Z.; Sciascio, G. Di; Feng, C. F.; Feng, Zhenyong; Collaboration: ARGO-YBJ Collaboration; and others

    2015-08-10

    This paper reports on the measurement of the large-scale anisotropy in the distribution of cosmic-ray arrival directions using the data collected by the air shower detector ARGO-YBJ from 2008 January to 2009 December, during the minimum of solar activity between cycles 23 and 24. In this period, more than 2 × 10{sup 11} showers were recorded with energies between ∼1 and 30 TeV. The observed two-dimensional distribution of cosmic rays is characterized by two wide regions of excess and deficit, respectively, both of relative intensity ∼10{sup −3} with respect to a uniform flux, superimposed on smaller size structures. The harmonic analysis shows that the large-scale cosmic-ray relative intensity as a function of R.A. can be described by the first and second terms of a Fouries series. The high event statistics allow the study of the energy dependence of the anistropy, showing that the amplitude increases with energy, with a maximum intensity at ∼10 TeV, and then decreases while the phase slowly shifts toward lower values of R.A. with increasing energy. The ARGO-YBJ data provide accurate observations over more than a decade of energy around this feature of the anisotropy spectrum.

  17. Exclusive muon neutrino charged current pion-less topologies. ArgoNeuT results and future prospects in LAr TPC detectors

    SciTech Connect

    Palamara, Ornella

    2016-12-29

    Results from the analysis of charged current pion-less (CC 0-pion) muon neutrino events in argon collected by the ArgoNeuT experiment on the NuMI beam at Fermilab are presented and compared with predictions from Monte Carlo simulations. A novel analysis method, based on the reconstruction of exclusive topologies, fully exploiting the Liquid argon Time Projection Chamber (LAr TPC) technique capabilities, is used to analyze the events, characterized by the presence at the vertex of a leading muon track eventually accompanied by one or more highly ionizing tracks, and study nuclear effects in neutrino interactions on argon nuclei. Multiple protons accompanying the leading muon are visible in the ArgoNeuT events, and measured with a proton reconstruction threshold of 21 MeV kinetic energy. As a result, measurements of (anti-)neutrino CC 0-pion inclusive and exclusive cross sections on argon nuclei are reported. Prospects for future, larger mass LAr TPC detectors are discussed.

  18. Exclusive muon neutrino charged current pion-less topologies. ArgoNeuT results and future prospects in LAr TPC detectors

    DOE PAGES

    Palamara, Ornella

    2016-12-29

    Results from the analysis of charged current pion-less (CC 0-pion) muon neutrino events in argon collected by the ArgoNeuT experiment on the NuMI beam at Fermilab are presented and compared with predictions from Monte Carlo simulations. A novel analysis method, based on the reconstruction of exclusive topologies, fully exploiting the Liquid argon Time Projection Chamber (LAr TPC) technique capabilities, is used to analyze the events, characterized by the presence at the vertex of a leading muon track eventually accompanied by one or more highly ionizing tracks, and study nuclear effects in neutrino interactions on argon nuclei. Multiple protons accompanying themore » leading muon are visible in the ArgoNeuT events, and measured with a proton reconstruction threshold of 21 MeV kinetic energy. As a result, measurements of (anti-)neutrino CC 0-pion inclusive and exclusive cross sections on argon nuclei are reported. Prospects for future, larger mass LAr TPC detectors are discussed.« less

  19. Hydrodynamic variability of the Cretan Sea derived from Argo float profiles and multi-parametric buoy measurements during 2010-2012

    NASA Astrophysics Data System (ADS)

    Kassis, Dimitris; Korres, Gerasimos; Petihakis, George; Perivoliotis, Leonidas

    2015-12-01

    In this work, we examine the complex hydrology of the Cretan Sea, an important area which affects the dynamics of the Eastern Mediterranean basin. We use T/S profile data derived from the first Argo float deployed in the area during June 2010 within the framework of the Greek Argo program. Temperature and salinity profiles were measured over a 2-year period, analyzed, and combined with time series data recorded from the POSEIDON E1-M3A multi-parametric instrumentation platform operating in the area since 2007. The acquired datasets have been enriched with available CTD profiles taken on the mooring site during cruise maintenance surveys. The combined research activities resulted in a large dataset of physical properties allowing extended geographical coverage and an in-depth analysis of the Cretan Sea dynamics during this 2-year period. Data analysis shows significant variability of water masses of different origin at subsurface and deep layers. This confirms previous findings describing the area as transitional with water masses of different origin meeting and interacting. Furthermore, additional features of the area are described combining information from satellite altimetry. In this study, new circulation systems are identified at intermediate and subsurface layers affecting both the dynamic behavior of the basin's upper thermocline and the intermediate/deep water mass tempo-spatial variability. We further investigate the physical properties of the water column and suggest an updated mesoscale circulation picture based on the dynamics of the variable hydrological regimes of the Cretan Sea basin.

  20. Interactions of Cosmic Rays in the primary energy range (0.1-1) PeV studied by the ARGO-YBJ Experiment

    NASA Astrophysics Data System (ADS)

    D'Amone, A.; De Mitri, I.; Surdo, A.

    2013-06-01

    The ARGO-YBJ detector layout, features and location offer a unique possibility for a detailed study of several characteristics of the hadronic component of the cosmic ray flux in an energy range hardly accessed by direct measurements. The proton-air cross section has already been measured by ARGO-YBJ in an energy region up to ~ 100 TeV where the primary cosmic ray composition is sufficiently well known for that measure to be unbiased. The analog readout of the RPC signals now provides new tools to measure the lateral distribution of particle density (LDF) as close as a few meters from the core and to investigate with unprecedented resolution the shower time structure. This allows to extend the hadronic interaction and mass composition studies up to ~PeV energies in the laboratory rest frame. Moreover, it is shown that the LDF of detected showers can be properly described, even very close to the shower axis, by a NKG-like function, whose shape parameter is clearly related to the shower age and can be used for studying the mass composition of cosmic rays.

  1. Detection of thermal neutrons with the PRISMA-YBJ array in extensive air showers selected by the ARGO-YBJ experiment

    NASA Astrophysics Data System (ADS)

    Bartoli, B.; Bernardini, P.; Bi, X. J.; Cao, Z.; Catalanotti, S.; Chen, S. Z.; Chen, T. L.; Cui, S. W.; Dai, B. Z.; D'Amone, A.; Danzengluobu; De Mitri, I.; D'Ettorre Piazzoli, B.; Di Girolamo, T.; Di Sciascio, G.; Feng, C. F.; Feng, Zhaoyang; Feng, Zhenyong; Gou, Q. B.; Guo, Y. Q.; He, H. H.; Hu, Haibing; Hu, Hongbo; Iacovacci, M.; Iuppa, R.; Jia, H. Y.; Labaciren; Li, H. J.; Liu, C.; Liu, J.; Liu, M. Y.; Lu, H.; Ma, L. L.; Ma, X. H.; Mancarella, G.; Mari, S. M.; Marsella, G.; Mastroianni, S.; Montini, P.; Ning, C. C.; Perrone, L.; Pistilli, P.; Salvini, P.; Santonico, R.; Shen, P. R.; Sheng, X. D.; Shi, F.; Surdo, A.; Tan, Y. H.; Vallania, P.; Vernetto, S.; Vigorito, C.; Wang, H.; Wu, C. Y.; Wu, H. R.; Xue, L.; Yang, Q. Y.; Yang, X. C.; Yao, Z. G.; Yuan, A. F.; Zha, M.; Zhang, H. M.; Zhang, L.; Zhang, X. Y.; Zhang, Y.; Zhao, J.; Zhaxiciren; Zhaxisangzhu; Zhou, X. X.; Zhu, F. R.; Zhu, Q. Q.; Stenkin, Yu. V.; Alekseenko, V. V.; Aynutdinov, V.; Cai, Z. Y.; Guo, X. W.; Liu, Y.; Rulev, V.; Shchegolev, O. B.; Stepanov, V.; Volchenko, V.; Zhang, H.

    2016-08-01

    We report on a measurement of thermal neutrons, generated by the hadronic component of extensive air showers (EAS), by means of a small array of EN-detectors developed for the PRISMA project (PRImary Spectrum Measurement Array), novel devices based on a compound alloy of ZnS(Ag) and 6LiF. This array has been operated within the ARGO-YBJ experiment at the high altitude Cosmic Ray Observatory in Yangbajing (Tibet, 4300 m a.s.l.). Due to the tight correlation between the air shower hadrons and thermal neutrons, this technique can be envisaged as a simple way to estimate the number of high energy hadrons in EAS. Coincident events generated by primary cosmic rays of energies greater than 100 TeV have been selected and analyzed. The EN-detectors have been used to record simultaneously thermal neutrons and the air shower electromagnetic component. The density distributions of both components and the total number of thermal neutrons have been measured. The correlation of these data with the measurements carried out by ARGO-YBJ confirms the excellent performance of the EN-detector.

  2. Sensitivity study of (10,100) GeV gamma-ray bursts with double shower front events from ARGO-YBJ

    NASA Astrophysics Data System (ADS)

    Zhou, Xun-Xiu; Gao, Lan-Lan; Zhang, Yu; Guo, Yi-Qing; Zhu, Qing-Qi; Jia, Huan-Yu; Huang, Dai-Hui

    2016-07-01

    ARGO-YBJ, located at the Yangbajing Cosmic Ray Observatory (4300 m a.s.l., Tibet, China), is a full coverage air shower array, with an energy threshold of ∼300 GeV for gamma-ray astronomy. Most of the recorded events are single front showers, satisfying the trigger requirement of at least 20 particles detected in a given time window. However, in ∼11.5% of the events, two randomly arriving showers may be recorded in the same time window, and the second one, generally smaller, does not need to satisfy the trigger condition. These events are called double shower front events. By using these small showers, well under the trigger threshold, the detector primary energy threshold can be lowered to a few tens of GeV. In this paper, the angular resolution that can be achieved with these events is evaluated by a full Monte Carlo simulation. The ARGO-YBJ sensitivity in detecting gamma-ray bursts (GRBs) by using double shower front events is also studied for various cutoff energies, time durations, and zenith angles of GRBs in ARGO’s field of view. Supported by National Natural Science Foundation of China (11475141) and Fundamental Research Funds for Central Universities (2682014CX091)

  3. OBSERVATION OF TeV GAMMA RAYS FROM THE UNIDENTIFIED SOURCE HESS J1841-055 WITH THE ARGO-YBJ EXPERIMENT

    SciTech Connect

    Bartoli, B.; Catalanotti, S.; Bernardini, P.; D'Amone, A.; Bi, X. J.; Cao, Z.; Chen, S. Z.; Chen, Y.; Bolognino, I.; Branchini, P.; Budano, A.; Calabrese Melcarne, A. K.; Cardarelli, R.; Cattaneo, C.; Chen, T. L.; Creti, P.; Cui, S. W.; Dai, B. Z.; D'Ali Staiti, G.; Collaboration: ARGO-YBJ Collaboration; and others

    2013-04-20

    We report the observation of a very high energy {gamma}-ray source whose position is coincident with HESS J1841-055. This source has been observed for 4.5 years by the ARGO-YBJ experiment from 2007 November to 2012 July. Its emission is detected with a statistical significance of 5.3 standard deviations. Parameterizing the source shape with a two-dimensional Gaussian function, we estimate an extension {sigma}=(0.40{sup +0.32}{sub -0.22}){sup o}, which is consistent with the HESS measurement. The observed energy spectrum is dN/dE = (9.0 {+-} 1.6) Multiplication-Sign 10{sup -13}(E/5 TeV){sup -2.32{+-}0.23} photons cm{sup -2} s{sup -1} TeV{sup -1}, in the energy range 0.9-50 TeV. The integral {gamma}-ray flux above 1 TeV is 1.3 {+-} 0.4 Crab, which is 3.2 {+-} 1.0 times the flux derived by HESS. The differences in the flux determination between HESS and ARGO-YBJ and possible counterparts at other wavelengths are discussed.

  4. Vertical temperature dynamics in the Northern Baltic Sea based on 3D modelling and data from shallow-water Argo floats

    NASA Astrophysics Data System (ADS)

    Westerlund, Antti; Tuomi, Laura

    2016-06-01

    3D hydrodynamic models often produce errors in the depth of the mixed layer and the vertical density structure. We used the 3D hydrodynamic model NEMO to investigate the effect of vertical turbulence parameterisations on seasonal temperature dynamics in the Bothnian Sea, Baltic Sea for the years 2012 and 2013. We used vertical profiles from new shallow-water Argo floats, operational in the area since 2012, to validate our model. We found that NEMO was able to reproduce the general features of the seasonal temperature variations in the study area, when meteorological forcing was accurate. The k-ε and k-ω schemes were selected for a more detailed analysis. Both schemes showed clear differences, but neither proved superior. While sea surface temperature was better simulated with the k-ω scheme, thermocline depth was clearly better with the k-ε scheme. We investigated the effect of wave-breaking on the mixing of the surface layer. The Craig and Banner parameterisation clearly improved the representation of thermocline depth. However, further tuning of the mixing parameterisations for the Baltic Sea is needed to better simulate the vertical temperature structure. We found the autonomous Baltic Sea Argo floats valuable for model validation and performance evaluation.

  5. Complete mitochondrial genome reveals the phylogenetic relationship of sable Martes zibellina linkouensis.

    PubMed

    Hua, Yan; Xu, Yanchun; Zhang, Wei; Li, Bo

    2017-03-01

    Over-hunting of the sable (Martes zibellina) in China since the 1950s has resulted in a dramatic decline of sable population size; and owing to effective conservation measures in recent years, sable populations in some areas are going through a rapid recovery. We first determined and annotated the whole mtDNA genome of the Lesser Khingan Mountains sable M. zibellina linkouensis to better understand the evolutionary relationship of this subspecies. The complete mitogenome is 16 460 bp in length, including 13 protein-coding genes, 22 tRNA genes, 2 rRNA genes, and 1 control region. We built the phylogenetic tree of three sable subspecies in Northeast China and other 10 species of Mustelinae.

  6. Soboliphyme baturini infection does not affect the nutritional condition of American marten (Martes americana) in Alaska.

    PubMed

    Thomas, J G; Pauli, J N; Donadio, E; Buskirk, S W

    2008-12-01

    Soboliphyme baturini, a stomach-dwelling nematode of American martens (Martes Americana), reaches high levels of infection; however, its effects on the nutritional condition of the host are unknown. To understand the effects of this parasite on American martens, we collected S. baturini and measured abdominal fat deposits from 155 marten carcasses on Prince of Wales Island, southeastern Alaska, in the winter 2006-2007. We analyzed how the dried mass of abdominal fat varied as a function of S. baturini intensity. Parasite intensity and nutritional condition were not correlated; these results suggest that American martens were able to withstand even very high levels of S. baturini infection (up to 178 parasites per host).

  7. Triterpene esters and biological activities from edible fruits of Manilkara subsericea (Mart.) Dubard, Sapotaceae.

    PubMed

    Fernandes, Caio P; Corrêa, Arthur L; Lobo, Jonathas F R; Caramel, Otávio P; de Almeida, Fernanda B; Castro, Elaine S; Souza, Kauê F C S; Burth, Patrícia; Amorim, Lidia M F; Santos, Marcelo G; Ferreira, José Luiz P; Falcão, Deborah Q; Carvalho, José C T; Rocha, Leandro

    2013-01-01

    Manilkara subsericea (Mart.) Dubard (Sapotaceae) is popularly known in Brazil as "guracica." Studies with Manilkara spp indicated the presence of triterpenes, saponins, and flavonoids. Several activities have been attributed to Manilkara spp such as antimicrobial, antiparasitic and antitumoral, which indicates the great biological potential of this genus. In all, 87.19% of the hexanic extract from fruits relative composition were evaluated, in which 72.81% were beta- and alpha-amyrin esters, suggesting that they may be chemical markers for M. subsericea. Hexadecanoic acid, hexadecanoic acid ethyl ester, (E)-9-octadecenoic acid ethyl ester, and octadecanoic acid ethyl ester were also identified. Ethanolic crude extracts from leaves, stems, and hexanic extract from fruits exhibited antimicrobial activity against Staphylococcus aureus ATCC25923. These extracts had high IC50 values against Vero cells, demonstrating weak cytotoxicity. This is the first time, to our knowledge, that beta- and alpha-amyrin caproates and caprylates are described for Manilkara subsericea.

  8. Peltomexicanin, a Peltogynoid Quinone Methide from Peltogyne Mexicana Martínez Purple Heartwood.

    PubMed

    Gutiérrez-Macías, Paulina; Peralta-Cruz, Javier; Borja-de-la-Rosa, Amparo; Barragán-Huerta, Blanca E

    2016-02-04

    Peltomexicanin (7,10-dihydroxy-6,12-dioxa-5H-tetraphen-3-one) is a new peltogynoid quinone methide isolated from Palo Morado (Peltogyne mexicana Martínez) heartwood by column chromatography. Its chemical structure was elucidated by IR, NMR (¹H, (13)C), 2D NMR experiments (COSY, NOESY, HMQC, and HSQC), ESI-MS, and UV-Vis spectroscopic analysis. According to HPLC quantification, this compound is the main pigment and accounts for 1.21% of Palo Morado heartwood material. The antioxidant activity of peltomexicanin and dried methanolic extract (DEx) of purple heartwood was evaluated using the radical of 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) assay, and the corresponding values expressed as Trolox equivalents (µmol TE/mg sample) were 4.25 and 4.57, respectively.

  9. Effect of rhizobacteria on arsenic uptake by macrophyte Eichhornia crassipes (Mart.) Solms.

    PubMed

    Kaur, Parvinder; Singh, Simranjeet; Kumar, Vivek; Singh, Nasib; Singh, Joginder

    2017-06-14

    Wastewater from municipal systems and industrial processes carries several trace metals including metalloid arsenic (As) which are considered serious environmental contaminants due to toxicity, and recalcitrant nature. In this study, we determined the phytoremediation of As by Eichhornia crassipes (Mart.) Solms either alone or in association with plant growth promoting rhizobacteria. Pseudomonas and Azotobacter inoculation to E. crassipes resulted in enhanced As removal compared to uninoculated control. Co-inoculation with a consortium of Pseudomonas, Azotobacter, Azospirillum, Actinomyces and Bacillus resulted in higher As (p<0.05) phytoaccumulation efficiency. P. aeruginosa strain jogii was found particularly effective in augmenting As removal by E. crassipes. Our findings indicate that the synergistic association of E. crassipes and various rhizobacteria, is an effective strategy to enhance removal of As and thus may be utilized as an efficient biological alternative for the removal of this metalloid from wastewaters.

  10. Chemical characterization and protective effect of the Bactris setosa Mart. fruit against oxidative/nitrosative stress.

    PubMed

    Boeing, Joana Schuelter; Ribeiro, Daniela; Chisté, Renan Campos; Visentainer, Jesuí Vergílio; Costa, Vera Marisa; Freitas, Marisa; Fernandes, Eduarda

    2017-04-01

    Bactris setosa Mart. is a Brazilian tree from the palm family (Arecaceae), whose fruits are scientifically underexploited. Here, we report, for the first time, the identification and quantification of phenolic compounds and carotenoids in the pulp, seed, and peel extracts of B. setosa fruits and their in vitro biological activity. The anthocyanins cyanidin deoxyhexose hexoside and cyanidin hexoside and other phenolic compounds were detected mainly in the peel but also in the pulp extracts. All-trans-lutein was the unique carotenoid identified and quantified, and only in the peel extract. All extracts were able to scavenge reactive oxygen and nitrogen species (ROS and RNS, respectively), to modulate human neutrophils' oxidative burst and to protect Caco-2 cells against oxidative damage, the peel extract being the most efficient. This study indicates that extracts from B. setosa fruits, especially the peel extract, are a source of bioactive compounds with promising antioxidant and anti-inflammatory properties.

  11. Triterpene Esters and Biological Activities from Edible Fruits of Manilkara subsericea (Mart.) Dubard, Sapotaceae

    PubMed Central

    Fernandes, Caio P.; Corrêa, Arthur L.; Lobo, Jonathas F. R.; Caramel, Otávio P.; de Almeida, Fernanda B.; Castro, Elaine S.; Souza, Kauê F. C. S.; Burth, Patrícia; Amorim, Lidia M. F.; Santos, Marcelo G.; Ferreira, José Luiz P.; Falcão, Deborah Q.; Carvalho, José C. T.; Rocha, Leandro

    2013-01-01

    Manilkara subsericea (Mart.) Dubard (Sapotaceae) is popularly known in Brazil as “guracica.” Studies with Manilkara spp indicated the presence of triterpenes, saponins, and flavonoids. Several activities have been attributed to Manilkara spp such as antimicrobial, antiparasitic and antitumoral, which indicates the great biological potential of this genus. In all, 87.19% of the hexanic extract from fruits relative composition were evaluated, in which 72.81% were beta- and alpha-amyrin esters, suggesting that they may be chemical markers for M. subsericea. Hexadecanoic acid, hexadecanoic acid ethyl ester, (E)-9-octadecenoic acid ethyl ester, and octadecanoic acid ethyl ester were also identified. Ethanolic crude extracts from leaves, stems, and hexanic extract from fruits exhibited antimicrobial activity against Staphylococcus aureus ATCC25923. These extracts had high IC50 values against Vero cells, demonstrating weak cytotoxicity. This is the first time, to our knowledge, that beta- and alpha-amyrin caproates and caprylates are described for Manilkara subsericea. PMID:23509702

  12. Genetic diversity of the Japanese Marten (Martes melampus) and its implications for the conservation unit.

    PubMed

    Sato, Jun J; Yasuda, Shumpei P; Hosoda, Tetsuji

    2009-07-01

    Molecular phylogenetic analyses of combined mitochondrial DNA sequences (2814 bp; cytochrome b gene, displacement loop region, and NADH dehydrogenase subunit 2 gene) identified nine groups among 49 individual Japanese martens, Martes melampus, collected from several areas in Japan. The grouping was not correlated with winter coat color, but was consistent with geography. In particular, the monophyly of 29 Tsushima martens, M. m. tsuensis, was supported by strong clade support and topological tests. Haplotype and nucleotide diversities were much lower for the Tsushima population than for any population on the Japanese main islands. In addition, analyses of heterozygosity in nuclear growth hormone receptor gene sequences (654 bp) showed genetic homogeneity for the Tsushima population. This evidence supports the view that the Tsushima marten's long history of isolation on small islands is responsible for its genetic distinctiveness and uniformity, validating the Tsushima population as an evolutionarily significant unit.

  13. Eichhornia crassipes (Mart) solms: from water parasite to potential medicinal remedy.

    PubMed

    Aboul-Enein, Ahmed M; Al-Abd, Ahmed M; Shalaby, Emad; Abul-Ela, Faten; Nasr-Allah, Amr A; Mahmoud, Ali M; El-Shemy, Hany A

    2011-06-01

    Water hyacinth, Eichhornia crassipes (Mart) Solms, originating in the amazonian basin, is a warm water aquatic plant. Water hyacinth is considered one of the most productive plants on earth and, accordingly, is considered one of the top 10 world's worst weeds. Water hyacinth spread to other tropical and subtropical regions by humans. It invaded about 62 countries in Africa, Asia and North America, and propagated extremely serious ecological, economical and social problems in the region between 40 degrees north and 45 degrees south. The dense weed of water hyacinth forms dense monocultures that can threaten local native species diversity and change the physical and chemical aquatic environment, thus altering ecosystem structure and function by disrupting food chains and nutrient cycling. We have separated and identified nine active fractions from water hyacinth and showed their promising therapeutic activities. Several compounds (alkaloid, phthalate derivatives, propanoid and phenyl derivatives) were identified in the extract of water hyacinth.

  14. Data mining using the Catalogue of Somatic Mutations in Cancer BioMart

    PubMed Central

    Shepherd, Rebecca; Forbes, Simon A.; Beare, David; Bamford, S.; Cole, Charlotte G.; Ward, Sari; Bindal, Nidhi; Gunasekaran, Prasad; Jia, Mingming; Kok, Chai Yin; Leung, Kenric; Menzies, Andrew; Butler, Adam P.; Teague, Jon W.; Campbell, Peter J.; Stratton, Michael R.; Futreal, P. Andrew

    2011-01-01

    Catalogue of Somatic Mutations in Cancer (COSMIC) (http://www.sanger.ac.uk/cosmic) is a publicly available resource providing information on somatic mutations implicated in human cancer. Release v51 (January 2011) includes data from just over 19 000 genes, 161 787 coding mutations and 5573 gene fusions, described in more than 577 000 tumour samples. COSMICMart (COSMIC BioMart) provides a flexible way to mine these data and combine somatic mutations with other biological relevant data sets. This article describes the data available in COSMIC along with examples of how to successfully mine and integrate data sets using COSMICMart. Database URL: http://www.sanger.ac.uk/genetics/CGP/cosmic/biomart/martview/ PMID:21609966

  15. Data mining using the Catalogue of Somatic Mutations in Cancer BioMart.

    PubMed

    Shepherd, Rebecca; Forbes, Simon A; Beare, David; Bamford, S; Cole, Charlotte G; Ward, Sari; Bindal, Nidhi; Gunasekaran, Prasad; Jia, Mingming; Kok, Chai Yin; Leung, Kenric; Menzies, Andrew; Butler, Adam P; Teague, Jon W; Campbell, Peter J; Stratton, Michael R; Futreal, P Andrew

    2011-01-01

    Catalogue of Somatic Mutations in Cancer (COSMIC) (http://www.sanger.ac.uk/cosmic) is a publicly available resource providing information on somatic mutations implicated in human cancer. Release v51 (January 2011) includes data from just over 19,000 genes, 161,787 coding mutations and 5573 gene fusions, described in more than 577,000 tumour samples. COSMICMart (COSMIC BioMart) provides a flexible way to mine these data and combine somatic mutations with other biological relevant data sets. This article describes the data available in COSMIC along with examples of how to successfully mine and integrate data sets using COSMICMart. DATABASE URL: http://www.sanger.ac.uk/genetics/CGP/cosmic/biomart/martview/.

  16. Genetic variability in the sable (Martes zibellina L.) with respect to genes encoding blood proteins

    SciTech Connect

    Kashtanov, S.N.; Kazakova, T.I.

    1995-02-01

    Electrophoresis of blood proteins was used to determine, for the first time, the level of genetic variability of certain loci in the sable (Martes zibellina L., Mustelidae). Variation of 23 blood proteins encoded by 25 genes was analyzed. Polymorphism was revealed in six genes. The level of heterozygosity was estimated at 0.069; the proportion of polymorphic loci was 24%. Data on the history of the sable population maintained at the farm, on geographical distribution of natural sable populations, and on the number of animals selected for reproduction in captivity is presented. The great number of animals studies and the extensive range of natural sable populations, on the basis of which the population maintained in captivity was obtained, suggest that the results of this work can be used for estimating the variability of the gene pool of sable as a species. 9 refs., 2 figs., 1 tab.

  17. Mars Analog Research and Technology Experiment (MARTE): A Simulated Mars Drilling Mission to Search for Subsurface Life at the Rio Tinto, Spain

    NASA Technical Reports Server (NTRS)

    Stoker, Carol; Lemke, Larry; Mandell, Humboldt; McKay, David; George, Jeffrey; Gomez-Alvera, Javier; Amils, Ricardo; Stevens, Todd; Miller, David

    2003-01-01

    The MARTE (Mars Astrobiology Research and Technology Experiment) project was selected by the new NASA ASTEP program, which supports field experiments having an equal emphasis on Astrobiology science and technology development relevant to future Astrobiology missions. MARTE will search for a hypothesized subsurface anaerobic chemoautotrophic biosphere in the region of the Tinto River in southwestern Spain while also demonstrating technology needed to search for a subsurface biosphere on Mars. The experiment is informed by the strategy for searching for life on Mars.

  18. Mars Analog Research and Technology Experiment (MARTE): A Simulated Mars Drilling Mission to Search for Subsurface Life at the Rio Tinto, Spain

    NASA Technical Reports Server (NTRS)

    Stoker, Carol; Lemke, Larry; Mandell, Humboldt; McKay, David; George, Jeffrey; Gomez-Alvera, Javier; Amils, Ricardo; Stevens, Todd; Miller, David

    2003-01-01

    The MARTE (Mars Astrobiology Research and Technology Experiment) project was selected by the new NASA ASTEP program, which supports field experiments having an equal emphasis on Astrobiology science and technology development relevant to future Astrobiology missions. MARTE will search for a hypothesized subsurface anaerobic chemoautotrophic biosphere in the region of the Tinto River in southwestern Spain while also demonstrating technology needed to search for a subsurface biosphere on Mars. The experiment is informed by the strategy for searching for life on Mars.

  19. An objective algorithm for estimating maximum oceanic mixed layer depth using seasonality indices derived from Argo temperature/salinity profiles

    NASA Astrophysics Data System (ADS)

    Chen, Ge; Yu, Fangjie

    2015-01-01

    In this study, we propose a new algorithm for estimating the annual maximum mixed layer depth (M2LD) analogous to a full range of local "ventilation" depth, and corresponding to the deepest surface to which atmospheric influence can be "felt." Two "seasonality indices" are defined, respectively, for temperature and salinity through Fourier analysis of their time series using Argo data, on the basis of which a significant local minimum of the index corresponding to a maximum penetration depth can be identified. A final M2LD is then determined by maximizing the thermal and haline effects. Unlike most of the previous schemes which use arbitrary thresholds or subjective criteria, the new algorithm is objective, robust, and property adaptive provided a significant periodic geophysical forcing such as annual cycle is available. The validity of our methodology is confirmed by the spatial correlation of the tropical dominance of saline effect (mainly related to rainfall cycle) and the extratropical dominance of thermal effect (mainly related to solar cycle). It is also recognized that the M2LD distribution is characterized by the coexistence of basin-scale zonal structures and eddy-scale local patches. In addition to the fundamental buoyancy forcing caused mainly by latitude-dependent solar radiation, the impressive two-scale pattern is found to be primarily attributable to (1) large-wave climate due to extreme winds (large scale) and (2) systematic eddy shedding as a result of persistent winds (mesoscale). Moreover, a general geographical consistency and a good quantitative agreement are found between the new algorithm and those published in the literature. However, a major discrepancy in our result is the existence of a constantly deeper M2LD band compared with other results in the midlatitude oceans of both hemispheres. Given the better correspondence of our M2LDs with the depth of the oxygen saturation limit, it is argued that there might be a systematic

  20. Induction of anti-melanoma CTL response using DC transfected with mutated mRNA encoding full-length Melan-A/MART-1 antigen with an A27L amino acid substitution.

    PubMed

    Abdel-Wahab, Zeinab; Kalady, Matthew F; Emani, Sirisha; Onaitis, Mark W; Abdel-Wahab, Omar I; Cisco, Robin; Wheless, Lee; Cheng, Tsung-Yen; Tyler, Douglas S; Pruitt, Scott K

    2003-08-01

    Modification of the parental immunodominant Melan-A/MART-1 peptide (MART-1(26-35)) by replacing the alanine with leucine (A27L) enhances its immunogenicity. Because of the reported advantages of RNA over peptides in DC vaccines, we sought to mutate the MART-1 gene to encode a full-length MART-1 antigen with an A27L amino acid substitution. Human DC were transfected with A27L-mutated MART-1 RNA (A27L RNA) or native MART-1 RNA, and then used to stimulate autologous T cells from a series of 8 HLA-A2+ volunteers. After three stimulations, all CTL induced with DC/A27L RNA exhibited more tetramer+ cells, and demonstrated stronger antigen-specific IFNgamma-secreting activity compared to CTL induced with DC/native RNA. A potent MART-1-specific, and predominantly class-I-restricted lysis was detected in most CTL induced with DC/A27L RNA, while native RNA-induced CTL showed minimal and non-specific lysis. HLA-A2+ DC and MART-1 negative/A2+ melanoma cells transfected with the A27L RNA were recognized and killed by MART-1-specific CTL, suggesting that these APC efficiently processed the A27L RNA and presented correct MART-1-specific epitope(s). In summary, introducing an A27L mutation into the MART-1 full-length mRNA sequence enhanced the immunogenicity of the encoded MART-1 Ag. The ease with which such a mutation can be made in RNA presents another potential advantage of using RNA for immunotherapy. Our results support considering this strategy for enhancing the immunogenicity of DC-based RNA vaccines.

  1. Analysis of Vertical Dynamics in the Northern Baltic Sea based on 3D Modelling and Data from Shallow-Water Argo Floats

    NASA Astrophysics Data System (ADS)

    Westerlund, Antti; Tuomi, Laura

    2016-04-01

    Vertical mixing is a challenge for ocean models. 3D hydrodynamic models often produce considerable errors in mixed layer depths and vertical temperature structure that can be related to the vertical turbulence parameterisation. These errors can be pronounced in areas with complex hydrography. In the Baltic Sea, for example, there are high horizontal and vertical salinity gradients. Furthermore, thermocline and halocline are located at different depths. This produces stratification conditions challenging for all ocean models. We studied vertical mixing with modelling experiments and new observational data. NEMO 3D ocean model has been set up at Finnish Meteorological Institute (FMI) for the Baltic Sea, based on the NEMO Nordic configuration. The model has been discretized on a Baltic Sea - North Sea grid with 2 nautical mile resolution and 56 vertical layers, using FMI-HIRLAM atmospheric forcing. The observational data for Baltic Sea off-shore areas is sparse and new methods are needed to collect data for model validation and development. FMI has been testing Argo floats in the Baltic Sea since 2011 in order to increase the amount of observed vertical profiles of salinity and temperature. This is the first time Argo floats have been successfully used in the brackish, shallow waters of the Baltic Sea. This new data set is well suited for evaluating the capability of hydrodynamic models to produce the vertical structure of temperature. It provides a time series of profiles from the area of interest with good temporal resolution, showing the structure of temperature in the water column throughout the summer. We found that NEMO was able to reproduce the general features of the seasonal temperature variations in the study area, when meteorological forcing was accurate. We ran the model with different vertical turbulence parameterisations. The k-ɛ and k-ω schemes showed clear differences, but neither proved superior. While sea surface temperature was better simulated

  2. Adoptive transfer of MART-1 T cell receptor transgenic lymphocytes and dendritic cell vaccination in patients with metastatic melanoma

    PubMed Central

    Chodon, Thinle; Comin-Anduix, Begonya; Chmielowski, Bartosz; Koya, Richard C; Wu, Zhongqi; Auerbach, Martin; Ng, Charles; Avramis, Earl; Seja, Elizabeth; Villanueva, Arturo; McCannel, Tara A.; Ishiyama, Akira; Czernin, Johannes; Radu, Caius G.; Wang, Xiaoyan; Gjertson, David W.; Cochran, Alistair J.; Cornetta, Kenneth; Wong, Deborah J.L.; Kaplan-lefko, Paula; Hamid, Omid; Samlowski, Wolfram; Cohen, Peter A.; Daniels, Gregory A.; Mukherji, Bijay; Yang, Lili; Zack, Jerome A.; Kohn, Donald B.; Heath, James R.; Glaspy, John A.; Witte, Owen N.; Baltimore, David; Economou, James S.; Ribas, Antoni

    2014-01-01

    Purpose It has been demonstrated that large numbers of tumor-specific T cells for adoptive cell transfer (ACT) can be manufactured by retroviral genetic engineering of autologous peripheral blood lymphocytes and expanding them over several weeks. In mouse models, this therapy is optimized when administered with dendritic cell (DC) vaccination. We developed a short one-week manufacture protocol to determine the feasibility, safety and antitumor efficacy of this double cell therapy. Experimnetal Design A clinical trial (NCT00910650) adoptively transferring MART-1 T cell receptor (TCR) transgenic lymphocytes together with MART-1 peptide pulsed DC vaccination in HLA-A2.1 patients with metastatic melanoma. Autologous TCR transgenic cells were manufactured in 6 to 7 days using retroviral vector gene transfer, and re-infused with (n = 10) or without (n = 3) prior cryopreservation. Results 14 patients with metastatic melanoma were enrolled and nine out of 13 treated patients (69%) showed evidence of tumor regression. Peripheral blood reconstitution with MART-1-specific T cells peaked within two weeks of ACT indicating rapid in vivo expansion. Administration of freshly manufactured TCR transgenic T cells resulted in a higher persistence of MART-1-specific T cells in the blood as compared to cryopreserved. Evidence that DC vaccination could cause further in vivo expansion was only observed with ACT using non-cryopreserved T cells. Conclusion Double cell therapy with ACT of TCR engineered T cells with a very short ex vivo manipulation and DC vaccines is feasible and results in antitumor activity, but improvements are needed to maintain tumor responses. PMID:24634374

  3. Immunohistochemical double stains against Ki67/MART1 and HMB45/MITF: promising diagnostic tools in melanocytic lesions.

    PubMed

    Nielsen, Patricia Switten; Riber-Hansen, Rikke; Steiniche, Torben

    2011-06-01

    Distinction between benign and malignant melanocytic lesions may be difficult by today's methods, even for highly skilled dermatopathologists, emphasizing the need for improved diagnostic tools. We have studied the discriminative abilities of immunohistochemical (IHC) double stains using the IHC markers Ki67 combined with MART1, and HMB45 combined with MITF. Paraffin-embedded tissue sections from 50 melanomas and 78 benign nevi were stained using a simple simultaneous IHC double staining technique. Both simple semiquantitative estimates of the immunopositivity in the deepest third of the lesions and full-scale quantitative measurements of the Ki67 and HMB45 indices were performed, and scores for melanomas and nevi were compared. The differences between melanomas and nevi were significant (P < 0.0001) using either analysis or stain. The misclassification rates for melanomas and nevi were generally lower for Ki67/MART1 stains than for HMB45/MITF stains. In the simple semiquantitative Ki67/MART1 analysis, the misclassification rates were 6% (2%-17%) for melanomas and 12% (6%-21%) for nevi. In full-scale quantitative analysis the corresponding rates were 4% (1%-14%) and 8% (4%-16%), and by combining Ki67 and HMB45 indices, the misclassification rates were 0% (0%-7%) for melanomas and 13% (7%-22%) for nevi. We conclude that both semiscale and fullscale quantitative analyses of Ki67/MART1 stains are valuable diagnostic tools to distinguish melanomas and nevi with a large degree of certainty. The HMB45/MITF stains may serve as adjuncts to predict malignancy and the diagnostic potential of combining the HMB45 and Ki67 indices are promising. The IHC double stains may potentially reduce misinterpretations of melanomas in histopathology.

  4. Genetic diversity, mating system, and conservation of a Mexican subalpine relict, Picea mexicana Martínez

    Treesearch

    F. Thomas Ledig; Paul D. Hodgskiss; Virginia Jacob-Cervantes

    2002-01-01

    Mexican spruce (Picea mexicana Martínez), an endangered species of the highest sky islands in México’s Sierra Madre Oriental and Sierra Madre Occidental, is threatened by fire, grazing, and global warming. Its conservation depends on whether it also is threatened by inbreeding and loss of genic diversity. We used 18 isozyme markers in 12 enzyme...

  5. Differences in healthy food supply and stocking practices between small grocery stores, gas-marts, pharmacies and dollar stores

    PubMed Central

    Caspi, Caitlin Eicher; Pelletier, Jennifer E.; Harnack, Lisa; Erikson, Darin J.; Laska, Melissa N.

    2015-01-01

    Objective Little is known about the practices for stocking and procuring healthy food in non-traditional food retailers (e.g., gas-marts, pharmacies). This study aimed to: (i) compare availability of healthy food items across small food store types, and (ii) examine owner/manager perceptions and stocking practices for healthy food across store types. Design Descriptive analyses were conducted among corner/small grocery stores, gas-marts, pharmacies, and dollar stores. Data from store inventories were used to examine availability of 12 healthy food types and an overall healthy food supply score. Interviews with managers assessed stocking practices and profitability. Setting Small stores in Minneapolis and St. Paul, MN not participating in the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) Subjects 119 small food retailers and 71 store managers Results Availability of specific items varied across store types. Only corner/small grocery stores commonly sold fresh vegetables (63%, versus 8% of food-gas marts, 0% dollar stores, and 23% pharmacies). More than half of managers stocking produce relied on cash and carry practices to stock fresh fruit (53%) and vegetables (55%), instead of direct store delivery. Most healthy foods were perceived by managers to have at least average profitability. Conclusions Interventions to improve healthy food offerings in small stores should consider the diverse environments, stocking practices and supply mechanisms of small stores, particularly non-traditional food retailers. Improvements may require technical support, customer engagement, and innovative distribution practices. PMID:26411535

  6. Design and practices for use of automated drilling and sample handling in MARTE while minimizing terrestrial and cross contamination.

    PubMed

    Miller, David P; Bonaccorsi, Rosalba; Davis, Kiel

    2008-10-01

    Mars Astrobiology Research and Technology Experiment (MARTE) investigators used an automated drill and sample processing hardware to detect and categorize life-forms found in subsurface rock at Río Tinto, Spain. For the science to be successful, it was necessary for the biomass from other sources--whether from previously processed samples (cross contamination) or the terrestrial environment (forward contamination)-to be insignificant. The hardware and practices used in MARTE were designed around this problem. Here, we describe some of the design issues that were faced and classify them into problems that are unique to terrestrial tests versus problems that would also exist for a system that was flown to Mars. Assessment of the biomass at various stages in the sample handling process revealed mixed results; the instrument design seemed to minimize cross contamination, but contamination from the surrounding environment sometimes made its way onto the surface of samples. Techniques used during the MARTE Río Tinto project, such as facing the sample, appear to remove this environmental contamination without introducing significant cross contamination from previous samples.

  7. Differences in healthy food supply and stocking practices between small grocery stores, gas-marts, pharmacies and dollar stores.

    PubMed

    Caspi, Caitlin Eicher; Pelletier, Jennifer E; Harnack, Lisa; Erickson, Darin J; Laska, Melissa N

    2016-02-01

    Little is known about the practices for stocking and procuring healthy food in non-traditional food retailers (e.g., gas-marts, pharmacies). The present study aimed to: (i) compare availability of healthy food items across small food store types; and (ii) examine owner/manager perceptions and stocking practices for healthy food across store types. Descriptive analyses were conducted among corner/small grocery stores, gas-marts, pharmacies and dollar stores. Data from store inventories were used to examine availability of twelve healthy food types and an overall healthy food supply score. Interviews with managers assessed stocking practices and profitability. Small stores in Minneapolis and St. Paul, MN, USA, not participating in the Special Supplemental Nutrition Program for Women, Infants, and Children. One hundred and nineteen small food retailers and seventy-one store managers. Availability of specific items varied across store type. Only corner/small grocery stores commonly sold fresh vegetables (63% v. 8% of gas-marts, 0% of dollar stores and 23% of pharmacies). More than half of managers stocking produce relied on cash-and-carry practices to stock fresh fruit (53%) and vegetables (55%), instead of direct store delivery. Most healthy foods were perceived by managers to have at least average profitability. Interventions to improve healthy food offerings in small stores should consider the diverse environments, stocking practices and supply mechanisms of small stores, particularly non-traditional food retailers. Improvements may require technical support, customer engagement and innovative distribution practices.

  8. Measurements of micron-scale meteoroids and orbital debris with the Space Dust (SPADUS) instrument on the upcoming ARGOS P91-1 mission

    NASA Technical Reports Server (NTRS)

    McKibben, R. B.; Simpson, J. A.; Tuzzolino, A. J.

    1997-01-01

    The space dust (SPADUS) experiment, to be launched into a sun-synchronous polar orbit at an altitude of 833 km onboard the USAF ARGOS P91-1 mission, will provide time-resolved measurements of the intensity, size spectrum and geocentric trajectories of dust particles encountered during the nominal three year mission. The experiment uses polyvinylidene fluoride dust sensors with a total detector area of 576 sq cm. The SPADUS will measure particle sizes between 2 and 200 microns, particle velocities between 1 and 10 km/s to better than 4 percent, and the direction of incidence with a mean error of 7 percent. These data will identify the particles as being debris or of natural origin.

  9. Sub-basin-scale sea level budgets from satellite altimetry, Argo floats and satellite gravimetry: a case study in the North Atlantic Ocean

    NASA Astrophysics Data System (ADS)

    Kleinherenbrink, Marcel; Riva, Riccardo; Sun, Yu

    2016-11-01

    In this study, for the first time, an attempt is made to close the sea level budget on a sub-basin scale in terms of trend and amplitude of the annual cycle. We also compare the residual time series after removing the trend, the semiannual and the annual signals. To obtain errors for altimetry and Argo, full variance-covariance matrices are computed using correlation functions and their errors are fully propagated. For altimetry, we apply a geographically dependent intermission bias [Ablain et al.(2015)], which leads to differences in trends up to 0.8 mm yr-1. Since Argo float measurements are non-homogeneously spaced, steric sea levels are first objectively interpolated onto a grid before averaging. For the Gravity Recovery And Climate Experiment (GRACE), gravity fields full variance-covariance matrices are used to propagate errors and statistically filter the gravity fields. We use four different filtered gravity field solutions and determine which post-processing strategy is best for budget closure. As a reference, the standard 96 degree Dense Decorrelation Kernel-5 (DDK5)-filtered Center for Space Research (CSR) solution is used to compute the mass component (MC). A comparison is made with two anisotropic Wiener-filtered CSR solutions up to degree and order 60 and 96 and a Wiener-filtered 90 degree ITSG solution. Budgets are computed for 10 polygons in the North Atlantic Ocean, defined in a way that the error on the trend of the MC plus steric sea level remains within 1 mm yr-1. Using the anisotropic Wiener filter on CSR gravity fields expanded up to spherical harmonic degree 96, it is possible to close the sea level budget in 9 of 10 sub-basins in terms of trend. Wiener-filtered Institute of Theoretical geodesy and Satellite Geodesy (ITSG) and the standard DDK5-filtered CSR solutions also close the trend budget if a glacial isostatic adjustment (GIA) correction error of 10-20 % is applied; however, the performance of the DDK5-filtered solution strongly depends

  10. Absolute-energy-scale calibration of ARGO-YBJ for light primaries in multi-TeV region with the Moon shadow observation

    NASA Astrophysics Data System (ADS)

    Bartoli, B.; Bernardini, P.; Bi, X. J.; Cao, Z.; Catalanotti, S.; Chen, S. Z.; Chen, T. L.; Cui, S. W.; Dai, B. Z.; D'Amone, A.; Danzengluobu; De Mitri, I.; D'Ettorre Piazzoli, B.; Di Girolamo, T.; Di Sciascio, G.; Feng, C. F.; Feng, Zhaoyang; Feng, Zhenyong; Gou, Q. B.; Guo, Y. Q.; He, H. H.; Hu, Haibing; Hu, Hongbo; Iacovacci, M.; Iuppa, R.; Jia, H. Y.; Labaciren; Li, H. J.; Liu, C.; Liu, J.; Liu, M. Y.; Lu, H.; Ma, L. L.; Ma, X. H.; Mancarella, G.; Mari, S. M.; Marsella, G.; Mastroianni, S.; Montini, P.; Ning, C. C.; Perrone, L.; Pistilli, P.; Salvini, P.; Santonico, R.; Shen, P. R.; Sheng, X. D.; Shi, F.; Surdo, A.; Tan, Y. H.; Vallania, P.; Vernetto, S.; Vigorito, C.; Wang, H.; Wu, C. Y.; Wu, H. R.; Xue, L.; Yang, Q. Y.; Yang, X. C.; Yao, Z. G.; Yuan, A. F.; Zha, M.; Zhang, H. M.; Zhang, L.; Zhang, X. Y.; Zhang, Y.; Zhao, J.; Zhaxiciren; Zhaxisangzhu; Zhou, X. X.; Zhu, F. R.; Zhu, Q. Q.; collaboration), (The ARGO-YBJ

    2017-04-01

    In 2011 ARGO-YBJ experiment has reported a work to study the absolute rigidity scale of the primary cosmic ray particles based on the Moon's shadow observation. Given the progress in high energy hadronic interaction models with LHC data, in cosmic ray chemical composition measurement and in experimental data accumulation, more updates can be researched. This paper aims to further disentangle the composition dependence in absolute-energy-scale calibration by using specific moon-shadow data which mainly is comprised of light component cosmic rays. Results show that, 17% energy scale error is estimated from 3 TeV to 50 TeV. To validate the performance of this technique, the light component cosmic ray spectrum in the same energy region is shown.

  11. Measurements of micron-scale meteoroids and orbital debris with the Space Dust (SPADUS) instrument on the upcoming ARGOS P91-1 mission

    NASA Technical Reports Server (NTRS)

    McKibben, R. B.; Simpson, J. A.; Tuzzolino, A. J.

    1997-01-01

    The space dust (SPADUS) experiment, to be launched into a sun-synchronous polar orbit at an altitude of 833 km onboard the USAF ARGOS P91-1 mission, will provide time-resolved measurements of the intensity, size spectrum and geocentric trajectories of dust particles encountered during the nominal three year mission. The experiment uses polyvinylidene fluoride dust sensors with a total detector area of 576 sq cm. The SPADUS will measure particle sizes between 2 and 200 microns, particle velocities between 1 and 10 km/s to better than 4 percent, and the direction of incidence with a mean error of 7 percent. These data will identify the particles as being debris or of natural origin.

  12. The Cosmic Ray p+He energy spectrum in the 3-3000 TeV energy range measured by ARGO-YBJ

    NASA Astrophysics Data System (ADS)

    Mari, S. M.; Montini, P.

    2016-07-01

    The ARGO-YBJ experiment is a full coverage air shower detector operated at the Yangbajing International Cosmic Ray Observatory. The detector has been in stable data taking in its full configuration since November 2007 to February 2013. The high altitude and the high segmentation and spacetime resolution offer the possibility to explore the cosmic ray energy spectrum in a very wide range, from a few TeV up to the PeV region. The high segmentation allows a detailed measurement of the lateral distribution, which can be used in order to discriminate showers produced by light and heavy elements. In this work we present the measurement of the cosmic ray light component spectrum in the energy range 3-3000 TeV. The analysis has been carried out by using a two-dimensional unfolding method based on the Bayes' theorem.

  13. A proposed vision: the transatlantic observatory for meeting global health policy challenges through information and communications technology-enabled solutions (ARGOS).

    PubMed

    Lorenzi, Nancy; De Moor, Georges; Bloomrosen, Meryl; Stroetmann, Karl

    2011-01-01

    In 2010 the ARGOS project was funded by the EC (DG RELEX) to contribute to the establishement of a "Transatlantic Observatory for meeting Global Health Policy Challenges through Information and Communication Technology-enabled solutions" to develop and promote common methods for responding to global eHealth challenges in the EU and the US. The European Institute for Health Records (EuroRec) was coordinating the project. The vision is that the Transatlantic Observatory will act as an international platform for dialogue and collaboration on health policy issues and will 1. build international consensus about how to improve the access, efficiency and quality of health services through ICT, 2. promote the importance of interoperability in eHealth, 3. help to define approaches to ensure that health data are easily available where it is needed, 4. identify optimal development paths.

  14. An atlas of monthly mean distributions of SSMI surface wind speed, ARGOS buoy drift, AVHRR/2 sea surface temperature, and ECMWF surface wind components during 1991

    NASA Technical Reports Server (NTRS)

    Halpern, D.; Knauss, W.; Brown, O.; Wentz, F.

    1993-01-01

    The following monthly mean global distributions for 1991 are presented with a common color scale and geographical map: 10-m height wind speed estimated from the Special Sensor Microwave Imager (SSMI) on a United States Air Force Defense Meteorological Satellite Program (DMSP) spacecraft; sea surface temperature estimated from the advanced very high resolution radiometer (AVHRR/2) on a U.S. National Oceanic and Atmospheric Administration (NOAA) spacecraft; Cartesian components of free-drifting buoys which are tracked by the ARGOS navigation system on NOAA satellites; and Cartesian components of the 10-m height wind vector computed by the European Center for Medium-Range Weather Forecasting (ECMWF). Charts of monthly mean value, sampling distribution, and standard deviation value are displayed. Annual mean distributions are displayed.

  15. An atlas of monthly mean distributions of SSMI surface wind speed, ARGOS buoy drift, AVHRR/2 sea surface temperature, and ECMWF surface wind components during 1990

    NASA Technical Reports Server (NTRS)

    Halpern, D.; Knauss, W.; Brown, O.; Wentz, F.

    1993-01-01

    The following monthly mean global distributions for 1990 are proposed with a common color scale and geographical map: 10-m height wind speed estimated from the Special Sensor Microwave Imager (SSMI) on a United States (US) Air Force Defense Meteorological Satellite Program (DMSP) spacecraft; sea surface temperature estimated from the advanced very high resolution radiometer (AVHRR/2) on a U.S. National Oceanic and Atmospheric Administration (NOAA) spacecraft; Cartesian components of free drifting buoys which are tracked by the ARGOS navigation system on NOAA satellites; and Cartesian components on the 10-m height wind vector computed by the European Center for Medium-Range Weather Forecasting (ECMWF). Charts of monthly mean value, sampling distribution, and standard deviation values are displayed. Annual mean distributions are displayed.

  16. Potential utility of three-dimensional temperature and salinity fields estimated from satellite altimetry and Argo data for improving mesoscale reproducibility in regional ocean modeling

    NASA Astrophysics Data System (ADS)

    Kanki, R.; Uchiyama, Y.; Miyazaki, D.; Takano, A.; Miyazawa, Y.; Yamazaki, H.

    2014-12-01

    Mesoscale oceanic structure and variability are required to be reproduced as accurately as possible in realistic regional ocean modeling. Uchiyama et al. (2012) demonstrated with a submesoscale eddy-resolving JCOPE2-ROMS downscaling oceanic modeling system that the mesoscale reproducibility of the Kuroshio meandering along Japan is significantly improved by introducing a simple restoration to data which we call "TS nudging" (a.k.a. robust diagnosis) where the prognostic temperature and salinity fields are weakly nudged four-dimensionally towards the assimilative JCOPE2 reanalysis (Miyazawa et al., 2009). However, there is not always a reliable reanalysis for oceanic downscaling in an arbitrary region and at an arbitrary time, and therefore alternative dataset should be prepared. Takano et al. (2009) proposed an empirical method to estimate mesoscale 3-D thermal structure from the near real-time AVISO altimetry data along with the ARGO float data based on the two-layer model of Goni et al. (1996). In the present study, we consider the TS data derived from this method as a candidate. We thus conduct a synoptic forward modeling of the Kuroshio using the JCOPE2-ROMS downscaling system to explore potential utility of this empirical TS dataset (hereinafter TUM-TS) by carrying out two runs with the T-S nudging towards 1) the JCOPE2-TS and 2) TUM-TS fields. An example of the comparison between the two ROMS test runs is shown in the attached figure showing the annually averaged surface EKE. Both of TUM-TS and JCOPE2-TS are found to help reproducing the mesoscale variance of the Koroshio and its extension as well as its mean paths, surface KE and EKE reasonably well. Therefore, the AVISO-ARGO derived empirical 3-D TS estimation is potentially exploitable for the dataset to conduct the T-S nudging to reproduce mesoscale oceanic structure.

  17. Bio-Argo float data suggest that disaggregation is a major driver of flux attenuation during large phytoplankton blooms in the North Atlantic

    NASA Astrophysics Data System (ADS)

    Briggs, N.; Claustre, H.; Dall'Olmo, G.; Bittig, H. C.

    2016-02-01

    Approximately 5-12 Pg of organic carbon is exported from the ocean's euphotic zone each year. The rate at which this organic carbon flux decreases with depth has critical consequences for both the functioning of deep ocean ecosystems and the timescale of biological CO2 sequestration. However, it has been difficult to constrain the mechanisms behind this attenuation of organic carbon flux and the variability of these mechanisms in time and space. In situ measurements of one or more individual processes that attenuate flux, therefore, are highly desirable, especially when accompanied by estimates of total flux attenuation at the same temporal and spatial scales. Substantial effort has been made to connect vertical flux attenuation with bacterial and/or zooplankton metabolism. However, the disaggregation of fast-sinking aggregates, another potential mechanism of flux attenuation, has not, to our knowledge, been quantified in the ocean. Here we simultaneously estimate both the loss of sinking phytoplankton aggregates with depth and the production of small particles at depth (possibly a signature disaggregation) using three years of chlorophyll a fluorescence data from 21 autonomous "bio-Argo" profiling floats in the sub-polar North Atlantic. Fluorescence data were divided into "spikes" caused by phytoplankton aggregates and a "baseline" due to smaller particles. During several large spring blooms, we found a clear matchup in depth and time between the attenuation of phytoplankton aggregate flux, calculated from fluorescence spikes, and a rapid increase in small phytoplankton particles well below the productive layer. This pattern is best explained by disaggregation, which appears to cause at least 30-50% of phytoplankton aggregate flux attenuation at the peak of these blooms. These results reveal the importance of disaggregation to oceanic carbon cycling and highlight the potential of bio-Argo to advance understanding of disaggregation globally.

  18. Thermohaline variability in the Adriatic and Northern Ionian Seas observed from the Argo floats during 2010-2014

    NASA Astrophysics Data System (ADS)

    Kovačević, Vedrana; Ursella, Laura; Gačić, Miroslav; Notarstefano, Giulio; Menna, Milena; Bensi, Manuel; Civitarese, Giuseppe; Poulain, Pierre-Marie

    2015-04-01

    , the signal of the Adriatic dense waters can be fairly irregular and impulsive. Sporadic in-situ surveys by research vessels are not always sufficient to capture this irregularity and its consequences on the circulation. The Lagrangian platforms are disseminated within the whole Mediterranean through the international Argo program. They are a useful tool to assess some of the spatial and temporal variability in the two basins. Combining the information from the floats and in-situ CTD profiles from oceanographic campaigns, we picture the inter-annual variability of the thermohaline properties in general during 2010-2014. In addition, the peculiarities of the very dense water overflow that during 2012 spilled out form the Strait of Otranto into the Northern Ionian is evidenced. Also, by the remotely sensed sea surface topography, we depict the most prominent circulation features of the upper layer.

  19. Phase I trial of a MART-1 peptide vaccine with incomplete Freund's adjuvant for resected high-risk melanoma.

    PubMed

    Wang, F; Bade, E; Kuniyoshi, C; Spears, L; Jeffery, G; Marty, V; Groshen, S; Weber, J

    1999-10-01

    Twenty-five patients with high-risk resected stages IIB, III, and IV melanoma were immunized with a vaccine consisting of the minimal epitope, immunodominant 9-amino acid peptide derived from the MART-1 tumor antigen (AAGIGILTV) complexed with incomplete Freund's adjuvant. The last three patients received the MART-1(27-35) peptide with incomplete Freund's adjuvant mixed with CRL 1005, a block copolymer adjuvant. Patients were immunized with increasing doses of the MART-1(27-35) peptide in a Phase I trial to evaluate the toxicity, tolerability, and immune responses to the vaccine. Immunizations were administered every 3 weeks for a total of four injections, preceded by leukapheresis to obtain peripheral blood mononuclear cells for immune analyses, followed by a post-vaccine leukapheresis 3 weeks after the fourth vaccination. Skin testing with peptide and standard delayed-type hypersensitivity skin test reagents was also performed before and after vaccinations. Local pain and granuloma formation were observed in the majority of patients, as were fevers or lethargy of grade 1 or 2. No vaccine-related grade III/IV toxicity was observed. The vaccine was felt to be well tolerated. Twelve of 25 patients were anergic to skin testing at the initiation of the trial, and 13 of 25 developed a positive skin test response to the MART-1(27-35) peptide. Immune responses were measured by release of IFN-gamma in an ELISA assay by effector cells after multiple restimulations of peripheral blood mononuclear cells in the presence of MART-1(27-35) peptide-pulsed antigen-presenting cells. An ELISPOT assay was also developed to measure more quantitatively the change in numbers of peptide-specific effector cells after vaccination. Ten of 22 patients demonstrated an immune response to peptide-pulsed targets or tumor cells by ELISA assay after vaccination, as did 12 of 20 patients by ELISPOT. Nine of 25 patients have relapsed with a median of 16 months of follow-up, and 3 patients in this

  20. Reviewers required major changes, including rearranging the two articles, so the new title of the first paper is: HVAC and Refrigeration Experiments at Wal-Mart Experimental Supercenters in Texas and Colorado --- original title: ASHRAE Journal DRAFT article McKinney and Aurora Wal-Mart Stores, Part 1

    SciTech Connect

    MacDonald, J Michael; Deru, Michael

    2007-01-01

    In 2005, Wal-Mart opened experimental stores in McKinney, Texas (hot climate), and Aurora, Colo. (cold climate). With these projects Wal-Mart can: * Learn how to achieve sustainability improvements; * Gain experience with the design, design process, and operations for some specific advanced technologies; * Understand energy use patterns in their stores more clearly; * Lay groundwork for better understanding of how to achieve major carbon footprint reductions; and * Measure the potential benefits of specific technologies tested.

  1. Interagency Pacific marten (Martes caurina) distribution study on the Olympic Peninsula, Washington

    USGS Publications Warehouse

    Moriarty, Katie; Howell, Betsy; Morozumi, Connor; Happe, Patti; Jenkins, Kurt J.; Aubry, Keith B.

    2016-01-01

    The objective of this study was to determine if the Pacific marten (Martes caurina) still occurs on the Olympic Peninsula in Washington State. We reviewed recent records of marten observations on the Olympic Peninsula since 1998, and conducted new surveys in undersampled regions of the Olympic Peninsula during summer, 2016. We reviewed evidence of fisher presence from 6 previously reported studies of carnivore distribution and presence on the Olympic Peninsula and conducted new surveys in previously undersampled areas of the Peninsula. We documented five highly reliable records of marten observations on the Pensula since 1988. Further, we established 197 camera stations in search of martens, amassing a total of 17,897 camera-nights of survey efforts in previously undersampled regions. We documented presence of one additional marten during summer 2016. This marten, however, was close to a marten detected in 2015, so it was not clear if it represented a different marten. We concluded that five to six martens have been verified present on the Olympic Peninsula since 1988. Pacific martens appear to be very limited in distribution and at critically low numbers throughout much of their former range on the Olympic Peninsula.

  2. Uniform fatty acid mobilization from anatomically distinct fat depots in the sable (Martes zibellina).

    PubMed

    Nieminen, Petteri; Mustonen, Anne-Mari

    2007-07-01

    The mobilization of fatty acids (FA) is a selective process in humans, rodents and the few previously studied carnivores. The FA composition of and mobilization from different fat depots reflect the functions of adipose tissues, e.g. in energy storage or insulation. Sixteen farm-raised sables (Martes zibellina), a terrestrial mustelid, were assigned into a fed control group or fasted for 4 days. The FA composition of the sable was relatively similar to other previously studied mustelids. The masses of the different fat depots decreased by 28-55% during fasting. The subcutaneous (sc) and intraabdominal (iab) fats had a uniform FA composition and the sable could mobilize both sc and iab FA. 18:3n-3, 18:4n-3 and 16:1n-7 were effectively mobilized, while long-chain saturated (SFA) and monounsaturated FA (MUFA) increased in proportion. Relative mobilization (RM) correlated inversely with the FA chain length and Delta9-desaturation increased RM of several MUFA compared to SFA. The results reinforce the hypothesis that the terrestrial sable can utilize sc and iab fat depots as energy reserves during nutritional scarcity. The natural history of the species is an important determinant of the FA composition and RM between anatomically different fat depots.

  3. [Microsatellite analysis of two captive populations of sable (Martes zibellina L.)].

    PubMed

    Kashtanov, S N; Afanas'ev, K I; Potapov, S G; Lazebnyĭ, O E

    2011-12-01

    The high value of sable (Martes zibellina L.) fur and stable demand for it over the centuries have led to suboptimal hunting patterns and, as a result, considerable fluctuations in the sizes of natural populations of this species. To maintain the traditional export of sable fur, efforts towards commercial domestication of sable have been made in Russia. The first farm population of sable consisted of animal from eight natural populations in 1929. After the problems related to breeding in captivity were solved, directional selection began. Eighty years of breeding have resulted in sable herds with homogeneous quantitative characters. Prospects for further breeding depend on the current level of genetic diversity in the captive populations of sables formed during the first stages of domestication. The sable populations of the Pushkinsky and Saltykovsky fur farms located in Moscow oblast, which were the objects of this study, are the progenitors of the existing captive populations. The first estimation of genetic variation of this species by means of a panel of microsatellite markers was developed for this study. Two captive sable populations were analyzed using ten microsatellite loci; a total of 75 alleles were found in both populations. Population-specific alleles were identified (6 and 13 in the Pushkinsky and Saltykovsky populations, respectively). The populations studied were found to be differentiated with respect to four microsatellite loci.

  4. Adaptations to fasting in a terrestrial mustelid, the sable (Martes zibellina).

    PubMed

    Mustonen, Anne-Mari; Puukka, Matti; Saarela, Seppo; Paakkonen, Tommi; Aho, Jari; Nieminen, Petteri

    2006-08-01

    The aim of this study was to investigate whether the actively wintering Palearctic sable Martes zibellina has evolved physiological adaptations to tolerate nutritional scarcity. Sixteen farm-bred male sables were divided into a fed control group and an experimental group fasted for 4 days. The rate of weight loss in the sable was similar to other medium-sized mustelids. Fasting led to hypoglycaemia and to a decreased lymphocyte percentage. The sable derived metabolic energy from both subcutaneous and intraabdominal white adipose tissues and the relative decrease in fat mass was the largest for the retroperitoneal and subcutaneous depots. Metabolic energy derived partly from body proteins indicated by the increased plasma levels of urea, uric acid and total essential amino acids. Triacylglycerols accumulated in the livers of the fasted sables and the increased plasma aminotransferase activities suggested hepatic dysfunction. The decreased plasma insulin concentrations and the elevated cortisol levels probably contributed to stimulated lipolysis and protein catabolism. Moreover, fasting increased the plasma ghrelin concentrations of the sables and down-regulated the thyroid activity.

  5. Eduardo Martínez Alonso (1903-72): gallant surgeon who undertook special operations.

    PubMed

    Coni, Nicholas

    2010-02-01

    Eduardo Martínez Alonso was of Spanish and Uruguyan extraction and was born in Vigo in Galicia in 1903. Due to his father's occupation, he was educated in the UK and qualified from the University of Liverpool. He returned to Madrid to practise and during the Civil War he found himself in the Republican zone where his connections with the Royal Family brought him under suspicion. Threatened with execution, he escaped to serve as a surgeon in the Nationalist Army. Being bilingual, he was medical adviser to the British Embassy during World War II; because of his allegiance to this country and acting from humanitarian motives, he became a ringleader in a plot to smuggle fugitives from Nazi-occupied Europe across a pro-Axis Spain to safety. When the Gestapo was closing in on him, he was smuggled to the UK via Portugal. He underwent training as a potential undercover agent should Franco take Spain into the war but, when hostilities ceased, he returned to Madrid and became a leading thoracic surgeon.

  6. Salinity Effects on Water Potential Components and Bulk Elastic Modulus of Alternanthera philoxeroides (Mart.) Griseb. 1

    PubMed Central

    Bolaños, Jorge A.; Longstreth, David J.

    1984-01-01

    Pressure volume curves for Alternanthera philoxeroides (Mart.) Griseb. (alligator weed) grown in 0 to 400 millimolar NaCl were used to determine water potential (Ψ), osmotic potential (ψs), turgor potential (ψp) and the bulk elastic modulus (ε) of shoots at different tissue water contents. Values of ψs decreased with increasing salinity and tissue Ψ was always lower than rhizosphere Ψ. The relationship between ψp and tissue water content changed because ε increased with salinity. As a result, salt-stressed plants had larger ranges of positive turgor but smaller ranges of tissue water content over which ψp was positive. To our knowledge, this is the first report of such a salinity effect on ε in higher plants. These increases in ε with salinity provided a mechanism by which a large difference between plant Ψ and rhizosphere Ψ, the driving force for water uptake, could be produced with relatively little water loss by the plant. A time-course study of response after salinization to 400 millimolar NaCl showed Ψ was constant within 1 day, ψs and ψp continued to change for 2 to 4 days, and ε continued to change for 4 to 12 days. Changes in ε modified the capacity of alligator weed to maintain a positive water balance and consideration of such changes in other species of higher plants should improve our understanding of salt stress. PMID:16663611

  7. Nitrogen-fixing bacteria and arbuscular mycorrhizal fungi in Piptadenia gonoacantha (Mart.) Macbr.

    PubMed

    Júnior, Joel Quintino de Oliveira; Jesus, Ederson da Conceição; Lisboa, Francy Junio; Berbara, Ricardo Luis Louro; Faria, Sergio Miana de

    The family Leguminosae comprises approximately 20,000 species that mostly form symbioses with arbuscular mycorrhizal fungi (AMF) and nitrogen-fixing bacteria (NFB). This study is aimed at investigating and confirming the dependence on nodulation and biological nitrogen fixation in the specie Piptadenia gonoacantha (Mart.) Macbr., which belongs to the Piptadenia group. Two consecutive experiments were performed in a greenhouse. The experiments were fully randomized with six replicates and a factorial scheme. For the treatments, the two AMF species and three NFB strains were combined to nodulate P. gonoacantha in addition to the control treatments. The results indicate this species' capacity for nodulation without the AMF; however, the AMF+NFB combinations yielded a considerable gain in P. gonoacantha shoot weight compared with the treatments that only included inoculating with bacteria or AMF. The results also confirm that the treatment effects among the AMF+NFB combinations produced different shoot dry weight/root dry weight ratios. We conclude that AMF is not necessary for nodulation and that this dependence improves species development because plant growth increases upon co-inoculation. Copyright © 2016 Sociedade Brasileira de Microbiologia. Published by Elsevier Editora Ltda. All rights reserved.

  8. Gastric Antiulcerogenic and Hypokinetic Activities of Terminalia fagifolia Mart. & Zucc. (Combretaceae)

    PubMed Central

    Nunes, Paulo Humberto M.; Martins, Maria do Carmo C.; Oliveira, Rita de Cássia M.; Chaves, Mariana H.; Sousa, Elcilene A.; Leite, José Roberto S. A.; Véras, Leiz Maria; Almeida, Fernanda Regina C.

    2014-01-01

    The acute toxicity, the antioxidant activity, and the pharmacological activity on the gastrointestinal tract of rodents of the ethanolic extract (TFEE) from the bark of Terminalia fagifolia Mart. & Zucc. (Combretaceae) and of its aqueous (TFAqF), hydroalcoholic (TFHAF), and hexanic (TFHEXF) partition fractions have been evaluated. TFEE presented low acute toxicity, antioxidant, and antiulcerogenic activity against ethanol-induced ulcers, which was partially blocked by pretreatment with L-NAME and indomethacin. It reduced the total acidity and raised the pH of gastric secretion. Additionally, TFEE delayed gastric emptying and slightly inhibited the small intestinal transit and also presented a weakly antidiarrheal activity. The antiulcerogenic and antioxidant activity were also detected in TFAqF and TFHAF but not in TFHEXF. The antisecretory and gastroprotective activity of TFEE partially involve the nitric oxide and prostaglandin participation. Nevertheless, TFEE, TFAqF, and TFHAF drastically reduced the mucus layer adhered to the gastric wall of rats treated with ethanol or indomethacin. Complementary studies are required in order to clarify the paradox of the presence of a gastroprotector activity in this plant that, at the same time, reduces the mucus layer adhered to the gastric wall. PMID:24900960

  9. Chemical Composition, Antifungal and Antioxidant Activities of Hedyosmum brasiliense Mart. ex Miq. (Chloranthaceae) Essential Oils

    PubMed Central

    Murakami, Cynthia; Cordeiro, Inês; Young, Maria Cláudia M.

    2017-01-01

    Background: Hedyosmum brasiliense Mart. ex Miq. (Chloranthaceae) is a dioecious shrub popularly used in Brazil to treat foot fungi and rheumatism. This work investigated the chemical composition, antifungal, and antioxidant activities of flowers and leaves of H. brasiliense essential oils; Methods: H. brasiliense male and female flowers and leaves were collected at Ilha do Cardoso (São Paulo) and the essential oils were extracted by hydrodistillation and analyzed by GC/MS and their similarity compared by Principal Component Analysis. Antifungal activity was performed by bioautography and antioxidant potential by 2,2-diphenyl-2-picrylhydrazyl hydrate (DPPH) free radical scavenging and β-carotene/linoleic acid system; Results: The major compounds for all oils were sabinene, curzerene, and carotol, but some differences in their chemical composition were discriminated by Principal Component Analysis (PCA) analysis. Bioautography showed two antifungal bands at Rf’s 0.67 and 0.12 in all samples, the first one was identified as curzerene. The oils presented stronger antioxidant potential in β-carotene/linoleic acid bioassay, with IC50’s from 80 to 180 μg/mL, than in DPPH assay, with IC50’s from 2516.18 to 3783.49 μg/mL; Conclusions: These results suggested that curzerene might be responsible for the antifungal activity of H. brasiliense essential oils. Besides, these essential oils exhibited potential to prevent lipoperoxidation, but they have a weak radical scavenger activity. PMID:28930269

  10. Mutagenicity and antimutagenicity of Salacia crassifolia (mart. Ex. Schult.) G. Don. evaluated by Ames test.

    PubMed

    Carneiro, C C; Véras, J Holanda; Góes, B R Lima; Pérez, C N; Chen-Chen, L

    2017-09-21

    Salacia crassifolia (Mart. Ex. Schult.) G. Don. is a bush which belongs to Celastraceae family and occurs specially in Brazilian Cerrado. Its leaves, stem, seeds and fruits are popularly used for several medicinal purposes, such as antitumoral, antirheumatic, anti-inflammatory and antimicrobial. In this study, the mutagenic and antimutagenic activities of S. crassifolia stem bark fractions (hexane, ethyl acetate and hydroalcoholic) were evaluated by the Ames mutagenicity assay in Salmonella typhimurium TA98 and TA100 strains. By the obtained results, all S. crassifolia fractions did not significantly increase the number of prototrophic revertants for histidine (His+) in both S. typhimurium strains tested (p > 0.05), suggesting absence of mutagenicity. Regarding antimutagenicity, the fractions ethyl acetate and hydroalcoholic significantly decreased the number of His+ revertants colonies induced by positive control for strain TA98 (p < 0.05), demonstrating protection against mutagenicity induced by 4-nitroquinolile1-oxide, whereas the hexane fraction did not show antimutagenic effect in this strain. In the TA100 strain, all fractions of S. crassifolia protected DNA against the harmful action of sodium azide, and the hexane fraction exhibited the greatest protection in this work. Thus, it's possible conclude that the fractions of S. crassifolia tested in this study could be used in chemoprevention.

  11. Toxicological and phytochemical studies of Aspidosperma subincanum Mart. stem bark (Guatambu).

    PubMed

    Santos, S R; Rangel, E T; Lima, J C S; Silva, R M; Lopes, L; Noldin, V F; Cechinel Filho, V; Delle Monache, F; Martins, D T O

    2009-12-01

    Aspidosperma subincanum Mart. is widely used in Brazilian folk medicine to treat digestive disorders. In this study, acute and subchronic toxicity and cytotoxicity of stem bark ethanolic extract of Aspidosperma subincanum (EEAs) have been evaluated. In addition, phytochemical analysis was performed. The EEAs had low acute toxicity in mice with LD50 =1129 +/- 154mg/kg p.o. and 397 +/- 15 mg/kg i.p. The LC50 was 1340 +/- 428 microg/mL in the brine shrimp assay. There was no relevance of serious changes in behavioral, hematological and biochemical parameters and no deleterious effect on vital organs of rats that resulted after 30 days daily exposure to 5 and 100 mg/kg of EEAs. Phytochemical analysis of stem bark of A. subincanum revealed the presence of indole alkaloids, saponins, terpenoids, steroids and tannins and resulted in the isolation of oleic acid and guatambuine as major constituents. Using the method of the dose by factor approach, the human safe dose was 210 mg/70 kg/day. The EEAs appears to be safe and non-toxic in low doses in rodents and domestic preparations used by population have relatively security.

  12. Chemical Constituents and Evaluation of Antimicrobial and Cytotoxic Activities of Kielmeyera coriacea Mart. & Zucc. Essential Oils

    PubMed Central

    Martins, Carla de M.; do Nascimento, Evandro A.; de Morais, Sérgio A. L.; de Oliveira, Alberto; Chang, Roberto; Cunha, Luís C. S.; Martins, Mário M.; Martins, Carlos Henrique G.; Moraes, Thaís da S.; Rodrigues, Paulla V.; da Silva, Cláudio V.; de Aquino, Francisco J. T.

    2015-01-01

    Many essential oils (EOs) of different plant species possess interesting antimicrobial effects on buccal microorganisms and cytotoxic properties. EOs of Kielmeyera coriacea Mart. & Zucc. were analyzed by gas chromatography coupled to mass spectrometry (GC-MS). The EO from leaves is rich in sesquiterpenes hydrocarbons and oxygenated sesquiterpenes. The three major compounds identified were germacrene-D (24.2%), (E)-caryophyllene (15.5%), and bicyclogermacrene (11.6%). The inner bark EO is composed mainly of sesquiterpenes hydrocarbons and the major components are alpha-copaene (14.9%) and alpha-(E)-bergamotene (13.0%). The outer bark EO is composed mainly of oxygenated sesquiterpenes and long-chain alkanes, and the major components are alpha-eudesmol (4.2%) and nonacosane (5.8%). The wood EO is mainly composed of long-chain alkanes and fatty acids, and the major components are nonacosane (9.7%) and palmitic acid (16.2%). The inner bark EO showed the strongest antimicrobial activity against the anaerobic bacteria Prevotella nigrescens (minimum inhibitory concentration-MIC of 50 µg mL−1). The outer bark and wood EOs showed MICs of 100 µg mL−1 for all aerobic microorganisms tested. The EOs presented low toxicity to Vero cells. These results suggest that K. coriacea, a Brazilian plant, provide initial evidence of a new and alternative source of substances with medicinal interest. PMID:25960759

  13. High-rate composting-vermicomposting of water hyacinth (Eichhornia crassipes, Mart. Solms).

    PubMed

    Gajalakshmi, S; Ramasamy, E V; Abbasi, S A

    2002-07-01

    In an attempt to develop a system with which the aquatic weed water hyacinth (Eichhornia crassipes, Mart. Solms) can be economically processed to generate vermicompost in large quantities, the weed was first composted by a 'high-rate' method and then subjected to vermicomposting in reactors operating at much larger densities of earthworm than recommended hitherto: 50, 62.5, 75, 87.5, 100, 112.5, 125, 137.5, and 150 adults of Eudrilus eugeniae Kinberg per litre of digester volume. The composting step was accomplished in 20 days and the composted weed was found to be vermicomposted three times as rapidly as uncomposted water hyacinth [Bioresource Technology 76 (2001) 177]. The studies substantiated the feasibility of high-rate composting-vermicomposting systems, as all reactors yielded consistent vermicast output during seven months of operation. There was no earthworm mortality during the first four months in spite of the high animal densities in the reactors. In the subsequent three months a total of 79 worms died out of 1650, representing less than 1.6% mortality per month. The results also indicated that an increase in the surface-to-volume ratio of the reactors might further improve their efficiency.

  14. Microbial enhancement of Cu2+ removal capacity of Eichhornia crassipes (Mart.).

    PubMed

    So, L M; Chu, L M; Wong, P K

    2003-09-01

    Bacteria resistant to Cu2+, Ni2+ or Zn2+ were isolated from the rhizosphere of water hyacinth (Eichhornia crassipes (Mart.)) and their metal ion removal capacities (RCs) were determined. The Ni2+ and Zn2+ RCs of the respective metal ion-resistant bacteria were less than 4.1 mg g(-1), while one of the Cu2+-resistant bacteria (Strain CU-1) showed a significant high Cu2+ RC of 10.6 mg g(-1). The effect of inoculating water hyacinth with Strain CU-1 on its Cu2+ RC was further studied. Water hyacinths were treated with an antibiotic, oxytetracycline (OTC), to remove most rhizospheric bacteria of plant roots. Inoculation of Strain CU-1 increased the Cu2+ RC of the plant root by 1.91 (OTC-treated) and 1.56 (OTC-untreated) folds respectively when compared with the control. Results also showed that Strain CU-1 colonized onto the plant root and led to the increase of Cu2+ RC of the roots of water hyacinth.

  15. Garcinielliptone FC, a polyisoprenylated benzophenone from Platonia insignis Mart., promotes vasorelaxant effect on rat mesenteric artery.

    PubMed

    Arcanjo, Daniel Dias Rufino; da Costa-Júnior, Joaquim Soares; Moura, Lucas Henrique Porfírio; Ferraz, Alexandre Barros Falcão; Rossatto, Raíssa Rebés; David, Jorge Maurício; Quintans-Júnior, Lucindo José; Oliveira, Rita de Cássia Meneses; Citó, Antônia Maria das Graças Lopes; de Oliveira, Aldeídia Pereira

    2014-01-01

    Polyisoprenylated benzophenones represent a group of chemical compounds commonly identified in Clusiaceae species and are responsible for a large amount of biological activities. In this work, the vasorelaxant effect induced by garcinielliptone FC (GFC) isolated from Platonia insignis Mart. (Clusiaceae), a monotype species from Platonia genus, was investigated. GFC promoted an endothelium-independent vasorelaxation on phenylephrine (PHE, 10(-5) mol L(-1))-induced vasoconstriction, but not on KCl (80 mmol L(-1))-induced vasoconstriction, on rat superior mesenteric artery rings. In addition, a concentration-dependent decrease of PHE- or serotonin-induced cumulative concentration-response curves was observed for GFC, and a slight decrease of pD₂ value on CaCl₂-induced vasoconstriction. In a Ca(2+)-free medium, GFC interfered in calcium mobilisation from PHE (10(-5) mol L(-1))-sensitive intracellular stores. GFC-induced vasorelaxant effect is probably mediated by a dual effect on mobilisation of calcium intracellular stores and attenuation of transmembrane calcium influx.

  16. Antibacterial and antifungal activities of acetonic extract from Paullinia cupana Mart. seeds.

    PubMed

    Basile, Adriana; Rigano, Daniela; Conte, Barbara; Bruno, Maurizio; Rosselli, Sergio; Sorbo, Sergio

    2013-01-01

    The antibacterial and antifungal activities of the acetone extract from Paullinia cupana var. sorbilis Mart. (Sapindaceae) seeds, commonly called guarana, were assessed against selected bacterial and fungal strains. We tested the extract against both standard American Type Culture Collection (ATCC) and clinically isolated (CI) bacterial strains and three fungal strains. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values for bacteria and MIC and minimum fungicidal concentration for fungi were determined. The extract showed an activity against the nine bacterial strains tested, both CI and ATCC strains (MIC comprised between 32 and 128 μm/mL and MBC between 128 and 512 μm/mL), showing a significant antibacterial effect against both Gram-negative and Gram-positive bacteria. Also, the tested fungi were sensitive to the extract (MIC between 125 and 250 μm/mL). The contemporaneous presence of different bioactivities in the extract from guarana suggests this plant as a source of bioactive substances.

  17. Orofacial antinociceptive effect of the ethanolic extract of Annona vepretorum Mart. (Annonaceae).

    PubMed

    Silva, Juliane C; Macedo, Larissa A R O; Souza, Grasielly R; Oliveira-Junior, Raimundo G; Lima-Saraiva, Sarah R G; Lavor, Érica M; Silva, Mariana G; Souza, Marilia T S; Bonjardim, Leonardo R; Quintans-Júnior, Lucindo J; Mendes, Rosemairy L; Almeida, Jackson R G S

    Annona vepretorum Mart. (Annonaceae) is a species popularly known in Brazil as "araticum" and "pinha da Caatinga". We have evaluated the antinociceptive effects of A. vepretorum in formalin-, capsaicin-, and glutamate-induced orofacial nociception in mice. Male Swiss mice were pretreated with either saline (p.o.), A. vepretorum ethanol extract (Av-EtOH 25, 50 and 100 mg/kg, p.o.), or morphine (10 mg/kg, i.p.), before formalin, capsaicin, or glutamate was injected into the right upper lip. Pre-treatment with Av-EtOH at all doses produced a reduction in face-rubbing behavior induced by formalin in both phases, and these pre-treatments also produced a significant antinociceptive effect in the capsaicin and glutamate tests. Pre-treatment with naloxone (1.5 mg/kg, i.p.) did not reverse the antinociceptive activity of the extract at the dose of 100 mg/kg in the first phase of this test. Our results suggest that Av-EtOH might be useful in the treatment of orofacial pain.

  18. Landscape genetics of fishers (Martes pennanti) in the Northeast: dispersal barriers and historical influences.

    PubMed

    Hapeman, Paul; Latch, Emily K; Fike, Jennifer A; Rhodes, Olin E; Kilpatrick, C William

    2011-01-01

    Habitat fragmentation and overtrapping are thought to have resulted in severe population declines for fisher (Martes pennanti) across the northeastern United States, and by the end of the 1930s only 3 remnant populations remained. Subsequent trapping cessation, extensive reintroduction programs, and natural recolonization have helped fishers to reclaim much of their historical range. The degree to which these processes have impacted genetic structure in this species, however, remains unknown. We used 11 microsatellites from tissue samples (n = 432) of fishers to characterize contemporary population structure in light of historical population structure and thus to determine the relative influence of anthropogenic disturbances and natural landscape features in shaping genetic structure of the contemporary population. Our results indicated that 3 well-differentiated contemporary populations are present that correspond well with what would be expected based on their reported history. A course barrier to dispersal appears in the western portion of the study area associated with several lakes including Lake George and Great Sacandaga Lake. Large-scale reintroduction efforts and natural recolonizations have largely had predictable impacts on population structure. An important exception is the substantial impact of the reintroduction of fishers to Vermont.

  19. Geographic characteristics of sable (Martes zibellina) distribution over time in Northeast China.

    PubMed

    Zhang, Rui; Yang, Li; Ai, Lin; Yang, Qiuyuan; Chen, Minhao; Li, Jingxi; Yang, Lei; Luan, Xiaofeng

    2017-06-01

    Understanding historical context can help clarify the ecological and biogeographic characteristics of species population changes. The sable (Martes zibellina) population has decreased dramatically in Northeast China since the l950s, and understanding the changes in its distribution over time is necessary to support conservation efforts. To achieve this goal, we integrated ecological niche modeling and historical records of sables to estimate the magnitude of change in their distribution over time. Our results revealed a 51.71% reduction in their distribution in 2000-2016 compared with the potential distribution in the 1950s. This reduction was related to climate change (Pearson's correlation: Bio1, -.962, p < .01; Bio2, -.962, p < .01; Bio5, .817, p < .05; Bio6, .847, p < .05) and human population size (-.956, p < .01). The sable population tended to migrate in different directions and elevations over time in different areas due to climate change: In the Greater Khingan Mountains, they moved northward and to lower elevations; in the Lesser Khingan Mountains, they moved northward; and in the Changbai Mountains, they move southward and to higher elevations. Active conservation strategies should be considered in locations where sable populations have migrated or may migrate to.

  20. Non-fermented and fermented jabuticaba (Myrciaria cauliflora Mart.) pomaces as valuable sources of functional ingredients.

    PubMed

    Morales, Patricia; Barros, Lillian; Dias, Maria Inês; Santos-Buelga, Celestino; Ferreira, Isabel C F R; Ramirez Asquieri, Eduardo; Berrios, José De J

    2016-10-01

    Jabuticaba (Myrciaria cauliflora. Mart) is a highly perishable fruit native to Brazil, which is consumed both fresh and industrially processed in the form of juices, jams, wines and distilled liqueurs. This processing generates a large amount of waste by-products, which represent approximately 50% of the fruit weight. The by-products are of interest for obtaining valuable bioactive compounds that could be used as nutraceuticals or functional ingredients. In this study, fermented and non-fermented jabuticaba pomaces were studied regarding their hydrophilic and lipophilic compounds, as well as their antioxidant properties, including: soluble sugars, organic acids and tocopherols (using high performance liquid chromatography coupled to refraction index, diode array and fluorescence detector, respectively); phenolics and anthocyanins, (using liquid chromatography coupled to diode array detection, and mass spectrometry with electrospray ionization); and fatty acids (using gas-liquid chromatography with flame ionization detection). The analytical data demonstrated that jabuticaba pomaces are a rich source of bioactive compounds such as tocopherols, polyunsaturated fatty acids and phenolic compounds (namely hydrolyzable tannins and anthocyanins) with antioxidant potential. Therefore, jabuticaba pomace may have good potential as a functional ingredient in the fabrication of human foods and animal feed. Copyright © 2016 Elsevier Ltd. All rights reserved.