Mathematically Reduced Chemical Reaction Mechanism Using Neural Networks
Ziaul Huque
2007-08-31
This is the final technical report for the project titled 'Mathematically Reduced Chemical Reaction Mechanism Using Neural Networks'. The aim of the project was to develop an efficient chemistry model for combustion simulations. The reduced chemistry model was developed mathematically without the need of having extensive knowledge of the chemistry involved. To aid in the development of the model, Neural Networks (NN) was used via a new network topology known as Non-linear Principal Components Analysis (NPCA). A commonly used Multilayer Perceptron Neural Network (MLP-NN) was modified to implement NPCA-NN. The training rate of NPCA-NN was improved with the GEneralized Regression Neural Network (GRNN) based on kernel smoothing techniques. Kernel smoothing provides a simple way of finding structure in data set without the imposition of a parametric model. The trajectory data of the reaction mechanism was generated based on the optimization techniques of genetic algorithm (GA). The NPCA-NN algorithm was then used for the reduction of Dimethyl Ether (DME) mechanism. DME is a recently discovered fuel made from natural gas, (and other feedstock such as coal, biomass, and urban wastes) which can be used in compression ignition engines as a substitute for diesel. An in-house two-dimensional Computational Fluid Dynamics (CFD) code was developed based on Meshfree technique and time marching solution algorithm. The project also provided valuable research experience to two graduate students.
Mathematically Reduced Chemical Reaction Mechanism Using Neural Networks
Nelson Butuk
2005-12-01
This is an annual technical report for the work done over the last year (period ending 9/30/2005) on the project titled ''Mathematically Reduced Chemical Reaction Mechanism Using Neural Networks''. The aim of the project is to develop an efficient chemistry model for combustion simulations. The reduced chemistry model will be developed mathematically without the need of having extensive knowledge of the chemistry involved. To aid in the development of the model, Neural Networks (NN) will be used via a new network topology know as Non-linear Principal Components Analysis (NPCA). We report on the development of a novel procedure to speed up the training of NPCA. The same procedure termed L{sub 2}Boost can be used to increase the order of approximation of the Generalized Regression Neural Network (GRNN). It is pointed out that GRNN is a basic procedure for the emerging mesh free CFD. Also reported is an efficient simple approach of computing the derivatives of GRNN function approximation using complex variables or the Complex Step Method (CSM). The results presented demonstrate the significance of the methods developed and will be useful in many areas of applied science and engineering.
Mathematically Reduced Chemical Reaction Mechanism Using Neural Networks
Nelson Butuk
2004-12-01
This is an annual technical report for the work done over the last year (period ending 9/30/2004) on the project titled ''Mathematically Reduced Chemical Reaction Mechanism Using Neural Networks''. The aim of the project is to develop an efficient chemistry model for combustion simulations. The reduced chemistry model will be developed mathematically without the need of having extensive knowledge of the chemistry involved. To aid in the development of the model, Neural Networks (NN) will be used via a new network topology know as Non-linear Principal Components Analysis (NPCA). We report on the development of a procedure to speed up the training of NPCA. The developed procedure is based on the non-parametric statistical technique of kernel smoothing. When this smoothing technique is implemented as a Neural Network, It is know as Generalized Regression Neural Network (GRNN). We present results of implementing GRNN on a test problem. In addition, we present results of an in house developed 2-D CFD code that will be used through out the project period.
Mathematically Reduced Chemical Reaction Mechanism Using Neural Networks
Nelson Butuk
2006-09-21
This is an annual technical report for the work done over the last year (period ending 9/30/2005) on the project titled ''Mathematically Reduced Chemical Reaction Mechanism Using Neural Networks''. The aim of the project is to develop an efficient chemistry model for combustion simulations. The reduced chemistry model will be developed mathematically without the need of having extensive knowledge of the chemistry involved. To aid in the development of the model, Neural Networks (NN) will be used via a new network topology know as Non-linear Principal Components Analysis (NPCA). We report on the significant development made in developing a truly meshfree computational fluid dynamics (CFD) flow solver to be coupled to NPCA. First, the procedure of obtaining nearly analytic accurate first order derivatives using the complex step method (CSM) is extended to include computation of accurate meshfree second order derivatives via a theorem described in this report. Next, boosted generalized regression neural network (BGRNN), described in our previous report is combined with CSM and used to obtain complete solution of a hard to solve wave dominated sample second order partial differential equation (PDE): the cubic Schrodinger equation. The resulting algorithm is a significant improvement of the meshfree technique of smooth particle hydrodynamics method (SPH). It is suggested that the demonstrated meshfree technique be termed boosted smooth particle hydrodynamics method (BSPH). Some of the advantages of BSPH over other meshfree methods include; it is of higher order accuracy than SPH; compared to other meshfree methods, it is completely meshfree and does not require any background meshes; It does not involve any construction of shape function with their associated solution of possibly ill conditioned matrix equations; compared to some SPH techniques, no equation for the smoothing parameter is required; finally it is easy to program.
Mathematical Modeling of Chemical Stoichiometry
ERIC Educational Resources Information Center
Croteau, Joshua; Fox, William P.; Varazo, Kristofoland
2007-01-01
In beginning chemistry classes, students are taught a variety of techniques for balancing chemical equations. The most common method is inspection. This paper addresses using a system of linear mathematical equations to solve for the stoichiometric coefficients. Many linear algebra books carry the standard balancing of chemical equations as an…
Reduce Skills Teaching in the Mathematics Class.
ERIC Educational Resources Information Center
Devlin, Keith
1999-01-01
Mathematics is much more than a collection of procedures for solving problems. Argues that the primary goal in the mathematics class is to create an awareness of the what, the how, and the why of mathematics. (ASK)
ERIC Educational Resources Information Center
Plaisance, DesLey Viator
2007-01-01
The purpose of this study was to identify factors that reduce mathematics anxiety in preservice elementary teachers enrolled in mathematics content courses. Students enrolled in ten sections of four different, required mathematics content courses in one specific semester were chosen as the population for this study. Approximately 180 students were…
Some Chemical Applications of the 'New' Mathematics
ERIC Educational Resources Information Center
Mooney, Arthur
1975-01-01
Indicates how some branches of chemistry lend themselves to interpretation using a modern mathematical approach. Examples include set theory and the periodic table, matrix algebra and determinants and atomic theory, and symmetry and molecular structure. (GS)
ERIC Educational Resources Information Center
Basitere, Moses; Ivala, Eunice
2015-01-01
This paper reports on a study carried out at a University of Technology, South Africa, aimed at identifying the existence of the mathematical knowledge gap and evaluating the intervention designed to bridge the knowledge gap amongst students studying first year mathematics at the Chemical Engineering Extended Curriculum Program (ECP). In this…
Chemical Literacy Levels of Science and Mathematics Teacher Candidates
ERIC Educational Resources Information Center
Celik, Suat
2014-01-01
The goal of this study was to investigate Turkish science and mathematics teacher candidates' levels of attainment in chemical literacy. These candidates had all studied the new Turkish chemistry curriculum in high school. The sample of the study consisted of 112 students, who were first-year students in the Department of Secondary Science…
Chemicals Reduce Need To Mow Grass
NASA Technical Reports Server (NTRS)
Humphrys, Brooks; Farley, Max; Gast, Larry J.
1993-01-01
Brief report discusses use of herbicides Roundup(R), Campaign(R), and Oust(R) to retard growth of Argentine bahia grass. Herbicide applied by use of spraying apparatus pulled by tractor. "Chemical mowing" keeps grass at "freshly mowed" height with less mechanical mowing. Applied to grass on shoulders of roads, reducing time spent on mowing.
Reduced graphene oxide by chemical graphitization.
Moon, In Kyu; Lee, Junghyun; Ruoff, Rodney S; Lee, Hyoyoung
2010-09-21
Reduced graphene oxides (RG-Os) have attracted considerable interest, given their potential applications in electronic and optoelectronic devices and circuits. However, very little is known regarding the chemically induced reduction method of graphene oxide (G-O) in both solution and gas phases, with the exception of the hydrazine-reducing agent, even though it is essential to use the vapour phase for the patterning of hydrophilic G-Os on prepatterned substrates and in situ reduction to hydrophobic RG-Os. In this paper, we report a novel reducing agent system (hydriodic acid with acetic acid (HI-AcOH)) that allows for an efficient, one-pot reduction of a solution-phased RG-O powder and vapour-phased RG-O (VRG-O) paper and thin film. The reducing agent system provided highly qualified RG-Os by mass production, resulting in highly conducting RG-O(HI-AcOH). Moreover, VRG-O(HI-AcOH) paper and thin films were prepared at low temperatures (40 °C) and were found to be applicable to flexible devices. This one-pot method is expected to advance research on highly conducting graphene platelets.
ERIC Educational Resources Information Center
Tooke, D. James; Lindstrom, Leonard C.
1998-01-01
Investigates three cases, in an attempt to find ways of reducing the mathematical anxiety of preservice elementary teachers. Teachers were administered the Mathematics Anxiety Rating Scale for Adults before and after the courses. Reports that no significant reduction of anxiety was detected in either mathematics section, but both sections of the…
A mathematical process model for cadmium precipitation by sulfate-reducing bacterial biofilms.
White, Christopher; Dennis, John S; Gadd, Geoffrey M
2003-04-01
Sulfate-reducing bacterial (SRB) biofilms were grown in a flowcell in which the biofilm was grown on a fixed area of support which was supplied with recirculating medium of defined composition, volume and circulation rate. Utilization rates for substrates, production rates for products and material mass-balances for substrates and Cd were determined and a mathematical model constructed based on theoretical considerations and experimental data. The rate of sulfate reduction was zero-order with respect to sulfate concentration and unaffected by the presence of 250 microM Cd. However, Cd reacted with the sulfide produced by the SRB to produce solid CdS, removing sulfide from solution. A significant fraction of colloidal CdS was formed which flocculated relatively slowly, limiting the overall rate of Cd bioprecipitation. Experiments using chemically-synthesised colloidal CdS indicated that the biofilm did not influence colloidal Cd flocculation but stimulated sedimentation of the CdS precipitate once flocculated. A mathematical model of bioprecipitation was developed in which the CdS formation rate was determined by two steps: sulfide production by the biofilm and colloidal CdS flocculation. This model accurately predicted the behaviour of further experimental runs which indicated the adequacy of the overall process description. The model also indicated that the rate of sulfate reduction and the rate of flocculation were the key variables in optimising the biofilm system for metal removal.
Gonsalves, Gregg S.; Kaplan, Edward H.; Paltiel, A. David
2015-01-01
Background Sexual violence is a major public health issue, affecting 35% of women worldwide. Major risk factors for sexual assault include inadequate indoor sanitation and the need to travel to outdoor toilet facilities. We estimated how increasing the number of toilets in an urban township (Khayelitsha, South Africa) might reduce both economic costs and the incidence and social burden of sexual assault. Methods We developed a mathematical model that links risk of sexual assault to the number of sanitation facilities and the time a woman must spend walking to a toilet. We defined a composite societal cost function, comprising both the burden of sexual assault and the costs of installing and maintaining public chemical toilets. By expressing total social costs as a function of the number of available toilets, we were able to identify an optimal (i.e., cost-minimizing) social investment in toilet facilities. Findings There are currently an estimated 5600 toilets in Khayelitsha. This results in 635 sexual assaults and US$40 million in combined social costs each year. Increasing the number of toilets to 11300 would minimize total costs ($35 million) and reduce sexual assaults to 446. Higher toilet installation and maintenance costs would be more than offset by lower sexual assault costs. Probabilistic sensitivity analysis shows that the optimal number of toilets exceeds the original allocation of toilets in the township in over 80% of the 5000 iterations of the model. Interpretation Improving access to sanitation facilities in urban settlements will simultaneously reduce the incidence of sexual assaults and overall cost to society. Since our analysis ignores the many additional health benefits of improving sanitation in resource-constrained urban areas (e.g., potential reductions in waterborne infectious diseases), the optimal number of toilets identified here should be interpreted as conservative. PMID:25923105
ERIC Educational Resources Information Center
Contreras-Ortega, C.; Bustamante, N.; Guevara, J. L.; Portillo, C.; Kesternich, V.
2007-01-01
A general mathematical treatment for chemical systems is described that might help students to better understand the real scope of the mathematical equations. The extent to which an equation acceptably describes a chemical system is determined from the limiting values of practical chemical variables and the concordance value defined by given…
Mathematical Model of Load Pass and Prediction of Fatigue Life on Bolt Threads with Reduced Lead
NASA Astrophysics Data System (ADS)
Asayama, Yukiteru
A mathematical model is proposed in order to elucidate the mechanism that the fatigue strength of external threads increases by reducing the lead on a thread system such as a bolt and nut. The model is constructed from the concept that a local strain proportional to the reducing degree of the lead, although the local strain is at first produced in the bolt thread farthest from the bearing surface of the nut, is induced in each thread root with an increase of applied load. The fatigue life predicted from the mathematical model shows good agreement with the experimental fatigue life of cadmium-plated external threads with the reduced lead on the material having strength as high as 1270MPa. The model can provide useful suggestions for the design of fasteners for aerospace, which are required to satisfy severe requirements of fatigue strengths and dimensions.
Mathematical Description of Complex Chemical Kinetics and Application to CFD Modeling Codes
NASA Technical Reports Server (NTRS)
Bittker, D. A.
1993-01-01
A major effort in combustion research at the present time is devoted to the theoretical modeling of practical combustion systems. These include turbojet and ramjet air-breathing engines as well as ground-based gas-turbine power generating systems. The ability to use computational modeling extensively in designing these products not only saves time and money, but also helps designers meet the quite rigorous environmental standards that have been imposed on all combustion devices. The goal is to combine the very complex solution of the Navier-Stokes flow equations with realistic turbulence and heat-release models into a single computer code. Such a computational fluid-dynamic (CFD) code simulates the coupling of fluid mechanics with the chemistry of combustion to describe the practical devices. This paper will focus on the task of developing a simplified chemical model which can predict realistic heat-release rates as well as species composition profiles, and is also computationally rapid. We first discuss the mathematical techniques used to describe a complex, multistep fuel oxidation chemical reaction and develop a detailed mechanism for the process. We then show how this mechanism may be reduced and simplified to give an approximate model which adequately predicts heat release rates and a limited number of species composition profiles, but is computationally much faster than the original one. Only such a model can be incorporated into a CFD code without adding significantly to long computation times. Finally, we present some of the recent advances in the development of these simplified chemical mechanisms.
Mathematical description of complex chemical kinetics and application to CFD modeling codes
NASA Technical Reports Server (NTRS)
Bittker, D. A.
1993-01-01
A major effort in combustion research at the present time is devoted to the theoretical modeling of practical combustion systems. These include turbojet and ramjet air-breathing engines as well as ground-based gas-turbine power generating systems. The ability to use computational modeling extensively in designing these products not only saves time and money, but also helps designers meet the quite rigorous environmental standards that have been imposed on all combustion devices. The goal is to combine the very complex solution of the Navier-Stokes flow equations with realistic turbulence and heat-release models into a single computer code. Such a computational fluid-dynamic (CFD) code simulates the coupling of fluid mechanics with the chemistry of combustion to describe the practical devices. This paper will focus on the task of developing a simplified chemical model which can predict realistic heat-release rates as well as species composition profiles, and is also computationally rapid. We first discuss the mathematical techniques used to describe a complex, multistep fuel oxidation chemical reaction and develop a detailed mechanism for the process. We then show how this mechanism may be reduced and simplified to give an approximate model which adequately predicts heat release rates and a limited number of species composition profiles, but is computationally much faster than the original one. Only such a model can be incorporated into a CFD code without adding significantly to long computation times. Finally, we present some of the recent advances in the development of these simplified chemical mechanisms.
37 CFR 1.58 - Chemical and mathematical formulae and tables.
Code of Federal Regulations, 2010 CFR
2010-07-01
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37 CFR 1.58 - Chemical and mathematical formulae and tables.
Code of Federal Regulations, 2011 CFR
2011-07-01
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37 CFR 1.58 - Chemical and mathematical formulae and tables.
Code of Federal Regulations, 2013 CFR
2013-07-01
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37 CFR 1.58 - Chemical and mathematical formulae and tables.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 37 Patents, Trademarks, and Copyrights 1 2012-07-01 2012-07-01 false Chemical and mathematical formulae and tables. 1.58 Section 1.58 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE GENERAL RULES OF PRACTICE IN PATENT CASES National...
37 CFR 1.58 - Chemical and mathematical formulae and tables.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false Chemical and mathematical formulae and tables. 1.58 Section 1.58 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE GENERAL RULES OF PRACTICE IN PATENT CASES National...
Reduced chemically modified graphene oxide for supercapacitor electrode
2014-01-01
An efficient active material for supercapacitor electrodes is prepared by reacting potassium hydroxide (KOH) with graphene oxide followed by chemical reduction with hydrazine. The electrochemical performance of KOH treated graphene oxide reduced for 24 h (reduced chemically modified graphene oxide, RCMGO-24) exhibits a specific capacitance of 253 F g-1 at 0.2 A g-1 in 2 M H2SO4 compared to a value of 141 F g-1 for graphene oxide reduced for 24 h (RGO-24), and good cyclic stability up to 3,000 cycles. Interestingly, RCMGO-24 demonstrated a higher specific capacitance and excellent cycle stability due to its residual oxygen functional groups that accelerate the faradaic reactions and aid in faster wetting. This non-annealed strategy offers the potential for simple and cost-effective preparation of an active material for a supercapacitor electrode. PMID:25298756
Chemical Analysis of NOx Removal Under Different Reduced Electric Fields
NASA Astrophysics Data System (ADS)
Haddouche, A.; Lemerini, M.
2015-07-01
This work presents a chemical kinetic analysis of different species involved in nitrogen-oxygen mixed gas induced by stationary corona discharge at room temperature and atmospheric pressure. This study takes into account twenty different chemical species participating in one hundred and seventy selected chemical reactions. The reaction rate coefficients are taken from the literature, and the density is analyzed by the continuity equation without the diffusion term. A large number of investigations considered the removal of NOx showing the effects of N, O and O3 radicals. The aim of the present simulation is to complete these studies by analysing various plasma species under different reduced electric fields in the range of 100-200 Td (1 Td=10-21 V·m2). In particular, we analyze the time evolution of depopulation (10-9-10-3 s) of NOx. We have found that the depopulation rate of NO and NO2 is substantially affected by the rise of reduced electric field as it grows from 100 Td to 200 Td. This allows us to ascertain the important role played by the reduced electric field.
Agricultural chemical application practices to reduce environmental contamination.
Bode, L E
1990-01-01
Current practices of applying agricultural chemicals play a major role in the environmental health concerns of agriculture. Those who mix, load, and handle the concentrated formulations run the greatest risk of exposure but field hands and others can encounter significant levels of pesticides. Drift can be a major source of contamination to residents, wildlife, and water sources. Improved methods of application and ways of reducing the total amount of pesticide applied can help reduce environmental contamination. Chemigation, direct injection, closed system handling, and fertilizer impregnation are examples of technology that affect the efficiency of applying agricultural chemicals. An area of beneficial research is related to leak and spill technology. Current surveys indicate that point sources such as spills, mixing and loading areas, back-siphoning, and direct routes for surface water movement into the ground are often a major cause of pesticides reaching groundwater. The commercial dealer/applicator provides storage, handling, mixing, and loading for large amounts of chemicals and has received limited guidance regarding the products. Education remains an important element of any rural environmental health strategy. With appropriate information about pesticide risks and groundwater, people will be better equipped to address environmental concerns. By design, agricultural chemicals are biologically active and, in most cases, toxic. Thus, they pose potential risks to humans, wildlife, water, and the environment in general. The magnitude of the risks depends to some degree on the methods and techniques used to apply the chemicals. Pesticides are applied by persons possessing a variety of skills, using equipment ranging from hand-operated systems to aircraft.
NASA Astrophysics Data System (ADS)
Konakov, S. A.; Krzhizhanovskaya, V. V.
2015-01-01
We developed a mathematical model of Plasma Enhanced Chemical Vapor Deposition (PECVD) of silicon nitride thin films from SiH4-NH3-N2-Ar mixture, an important application in modern materials science. Our multiphysics model describes gas dynamics, chemical physics, plasma physics and electrodynamics. The PECVD technology is inherently multiscale, from macroscale processes in the chemical reactor to atomic-scale surface chemistry. Our macroscale model is based on Navier-Stokes equations for a transient laminar flow of a compressible chemically reacting gas mixture, together with the mass transfer and energy balance equations, Poisson equation for electric potential, electrons and ions balance equations. The chemical kinetics model includes 24 species and 58 reactions: 37 in the gas phase and 21 on the surface. A deposition model consists of three stages: adsorption to the surface, diffusion along the surface and embedding of products into the substrate. A new model has been validated on experimental results obtained with the "Plasmalab System 100" reactor. We present the mathematical model and simulation results investigating the influence of flow rate and source gas proportion on silicon nitride film growth rate and chemical composition.
NASA Astrophysics Data System (ADS)
Davis, T. J.; McAllister, T.; Maslen, V.; Wilkins, S. W.; Faith, M.; Leech, P.
1993-10-01
A mathematical model is used to calculate the deposition profile of CdTe in a horizontal pre-cracker metalorganic chemical vapour deposition (MOCVD) reactor. The model is solved numerically in two dimensions, yielding the temperature profile in the reactor and the concentrations of chemical species. The calculated deposition profiles are compared with growths of CdTe on glass. With appropriate approximations, the model is reduced to a simple form which is solved analytically. This model has enabled us to identify the cause of the non-uniformity in the deposition profile as a variation in the rate of supply of metal vapour. By optimizing the reactor temperature and the gas flow rates, high-uniformity CdTe films have been grown on GaAs substrates.
Reduced hazard chemicals for solid rocket motor production
NASA Technical Reports Server (NTRS)
Caddy, Larry A.; Bowman, Ross; Richards, Rex A.
1995-01-01
During the last three years. the NASA/Thiokol/industry team has developed and started implementation of an environmentally sound manufacturing plan for the continued production of solid rocket motors. NASA Marshall Space Flight Center (MSFC) and Thiokol Corporation have worked with other industry representatives and the U.S. Environmental Protection Agency (EPA) to prepare a comprehensive plan to eliminate all ozone depleting chemicals from manufacturing processes and reduce the use of other hazardous materials used to produce the space shuttle reusable solid rocket motors. The team used a classical approach for problem-solving combined with a creative synthesis of new approaches to attack this challenge.
A mathematical model for the transport and fate of organic chemicals in unsaturated/saturated soils.
Lindstrom, F T; Piver, W T
1985-01-01
A mathematical model, simulating the transport and fate of nonionizable organic compounds in unsaturated/saturated porous media (soils) in a terrestrial microcosm has been developed. Using the principles of water mass, momentum, heat energy and chemical mass balance, the three fields: moisture, temperature, and liquid phase chemical concentration are solved for simultaneously by coupling the soil slab to an environmentally realistic air-soil interface (a dynamic free boundary) conditions and a prescribed height water table. The environmental conditions at the soil surface-air chamber interface are easily changed, via geometric scaling factors, to simulate either an open agricultural field or a landfill type of situation. Illustrative simulation runs examine the effects of different soil-chemical characteristics on hydrological and chemical concentration profiles. PMID:4029096
Mathematical modeling to reduce waste of compounded sterile products in hospital pharmacies.
Tilson, Vera; Dobson, Gregory; Haas, Curtis E; Tilson, David
2014-07-01
In recent years, many US hospitals embarked on "lean" projects to reduce waste. One advantage of the lean operational improvement methodology is that it relies on process observation by those engaged in the work and requires relatively little data. However, the thoughtful analysis of the data captured by operational systems allows the modeling of many potential process options. Such models permit the evaluation of likely waste reductions and financial savings before actual process changes are made. Thus the most promising options can be identified prospectively, change efforts targeted accordingly, and realistic targets set. This article provides one example of such a datadriven process redesign project focusing on waste reduction in an in-hospital pharmacy. A mathematical model of the medication prepared and delivered by the pharmacy is used to estimate the savings from several potential redesign options (rescheduling the start of production, scheduling multiple batches, or reordering production within a batch) as well as the impact of information system enhancements. The key finding is that mathematical modeling can indeed be a useful tool. In one hospital setting, it estimated that waste could be realistically reduced by around 50% by using several process changes and that the greatest benefit would be gained by rescheduling the start of production (for a single batch) away from the period when most order cancellations are made. PMID:25477580
Mathematical modeling to reduce waste of compounded sterile products in hospital pharmacies.
Tilson, Vera; Dobson, Gregory; Haas, Curtis E; Tilson, David
2014-07-01
In recent years, many US hospitals embarked on "lean" projects to reduce waste. One advantage of the lean operational improvement methodology is that it relies on process observation by those engaged in the work and requires relatively little data. However, the thoughtful analysis of the data captured by operational systems allows the modeling of many potential process options. Such models permit the evaluation of likely waste reductions and financial savings before actual process changes are made. Thus the most promising options can be identified prospectively, change efforts targeted accordingly, and realistic targets set. This article provides one example of such a datadriven process redesign project focusing on waste reduction in an in-hospital pharmacy. A mathematical model of the medication prepared and delivered by the pharmacy is used to estimate the savings from several potential redesign options (rescheduling the start of production, scheduling multiple batches, or reordering production within a batch) as well as the impact of information system enhancements. The key finding is that mathematical modeling can indeed be a useful tool. In one hospital setting, it estimated that waste could be realistically reduced by around 50% by using several process changes and that the greatest benefit would be gained by rescheduling the start of production (for a single batch) away from the period when most order cancellations are made.
Restrepo-Alape, Leonardo D; Toro-Zapata, Hernán D; Muñoz-Loaiza, Aníbal
2010-12-01
Dengue fever is a common vector-borne disease in tropical and subtropical areas. It is transmitted to humans by the bite of an infected female Aedes mosquito. Since no vaccines are currently available which can protect against infection, disease control relies on controlling the mosquito population. This work was aimed at modelling such mosquito's population dynamics regarding chemical control of the adult population and its acquired resistance to chemicals. The model was analysed by using classical dynamic system theory techniques and mosquito growth threshold was determined as this establishes when a particular population may prosper in the environment or when it is likely to disappear. A suitable chemical control strategy was developed from such threshold. Simulations were made in control and non-control scenarios; this determined the degree of control application effectiveness against different levels of acquired resistance.
Restrepo-Alape, Leonardo D; Toro-Zapata, Hernán D; Muñoz-Loaiza, Aníbal
2010-12-01
Dengue fever is a common vector-borne disease in tropical and subtropical areas. It is transmitted to humans by the bite of an infected female Aedes mosquito. Since no vaccines are currently available which can protect against infection, disease control relies on controlling the mosquito population. This work was aimed at modelling such mosquito's population dynamics regarding chemical control of the adult population and its acquired resistance to chemicals. The model was analysed by using classical dynamic system theory techniques and mosquito growth threshold was determined as this establishes when a particular population may prosper in the environment or when it is likely to disappear. A suitable chemical control strategy was developed from such threshold. Simulations were made in control and non-control scenarios; this determined the degree of control application effectiveness against different levels of acquired resistance. PMID:22030690
Mathematical modelling of some chemical and physical processes in underground coal gasification
Creighton, J. R.
1981-08-01
Underground coal gasification normally involves two vertical wells which must be linked by a channel having low resistance to gas flow. There are several ways of establishing such linkage, but all leave a relatively open horizontal hole with a diameter on the order of a meter. To increase our understanding of the chemical and physical processes governing underground coal gasification LLNL has been conducting laboratory scale experiments accompanied by mathematical modelling. Blocks of selected coal types are cut to fit 55 gallon oil drums and sealed in place with plaster. A 1 cm. diameter hole is drilled the length of the block and plumbing attached to provide a flow of air or oxygen/steam mixture. After an instrumented burn the block is sawed open to examine the cavity. Mathematical modelling has been directed towards predicting the cavity shape. This paper describes some sub-models and examines their impact on predicted cavity shapes.
A multipurpose reduced chemical-kinetic mechanism for methanol combustion
NASA Astrophysics Data System (ADS)
Fernández-Tarrazo, Eduardo; Sánchez-Sanz, Mario; Sánchez, Antonio L.; Williams, Forman A.
2016-07-01
A multipurpose reduced chemical-kinetic mechanism for methanol combustion comprising 8 overall reactions and 11 reacting chemical species is presented. The development starts by investigating the minimum set of elementary reactions needed to describe methanol combustion with reasonable accuracy over a range of conditions of temperature, pressure, and composition of interest in combustion. Starting from a 27-step mechanism that has been previously tested and found to give accurate predictions of ignition processes for these conditions, it is determined that the addition of 11 elementary reactions taken from its basis (San Diego) mechanism extends the validity of the description to premixed-flame propagation, strain-induced extinction of non-premixed flames, and equilibrium composition and temperatures, giving results that compare favourably with experimental measurements and also with computations using the 247-step detailed San Diego mechanism involving 50 reactive species. Specifically, premixed-flame propagation velocities and extinction strain rates for non-premixed counterflow flames calculated with the 38-step mechanism show departures from experimental measurements and detailed-chemistry computations that are roughly on the order of 10%, comparable with expected experimental uncertainties. Similar accuracy is found in comparisons of autoignition times over the range considered, except at very high temperatures, under which conditions the computations tend to overpredict induction times for all of the chemistry descriptions tested. From this 38-step mechanism, the simplification is continued by introducing steady-state approximations for the intermediate species CH3, CH4, HCO, CH3O, CH2OH, and O, leading to an 8-step reduced mechanism that provides satisfactory accuracy for all conditions tested. The flame computations indicate that thermal diffusion has a negligible influence on methanol combustion in all cases considered and that a mixture-average species
A mathematical model for targeting chemicals to tissues by exploiting complex degradation
2011-01-01
Background In many biological and therapeutic contexts, it is highly desirable to target a chemical specifically to a particular tissue where it exerts its biological effect. In this paper, we present a simple, generic, mathematical model that elucidates a general method for targeting a chemical to particular tissues. The model consists of coupled reaction-diffusion equations to describe the evolution within the tissue of the concentrations of three chemical species: a (concentration of free chemical), b (binding protein) and their complex, c (chemical bound to binding protein). We assume that all species are free to diffuse, and that a and b undergo a reversible reaction to form c. In addition, the complex, c, can be broken down by a process (e.g. an enzyme in the tissue) that results in the release of the chemical, a, which is then free to exert its biological action. Results For simplicity, we consider a one-dimensional geometry. In the special case where the rate of complex formation is small (compared to the diffusion timescale of the species within the tissue) the system can be solved analytically. This analytic solution allows us to show how the concentration of free chemical, a, in the tissue can be increased over the concentration of free chemical at the tissue boundary. We show that, under certain conditions, the maximum concentration of a can occur at the centre of the tissue, and give an upper bound on this maximum level. Numerical simulations are then used to determine how the behaviour of the system changes when the assumption of negligible complex formation rate is relaxed. Conclusions We have shown, using our mathematical model, how complex degradation can potentially be exploited to target a chemical to a particular tissue, and how the level of the active chemical depends on factors such as the diffusion coefficients and degradation/production rates of each species. The biological significance of these results in terms of potential applications in
Perceptions of College Students on Successful Strategies for Reducing Mathematics Anxiety
ERIC Educational Resources Information Center
Allen, Amelia Ann
2011-01-01
Despite more than 50 years of attempts to improve mathematics education and the simultaneous prevalence of fears associated with learning mathematics in the United States, the problem of mathematics anxiety among students still remains. This qualitative phenomenological study was focused on understanding college students' perceptions regarding the…
[Reducing nutrients loss by plastic film covering chemical fertilizers].
Chen, Huo-jun; Wei, Ze-bin; Wu, Qi-tang; Zeng, Shu-cai
2010-03-01
With the low utilization rate of fertilizers by crop and the growing amount of fertilizer usage,the agricultural non-point source pollution in China is becoming more and more serious. The field experiments planting corns were conducted, in which the applied chemical fertilizers were recovered with plastic film to realize the separation of fertilizers from rain water. In the experiments, the influences of different fertilizing treatments on the growing and production of sweet corn were observed. The fertilizer utilization rate and the nutrient contents in surface run-off water with and without the film covering were also determined. Results showed that, with only 70% of the normal amount of fertilizers,the sweet corn could already get high yield under the experimental soil conditions. Soil analysis after corn crops showed that the amounts of available N, P and K in the soil increased obviously with the film-covering, and the decreasing order was: 100% fertilizers with film-covering > 70% fertilizers with film-covering > 100% fertilizers, 70% fertilizers > no fertilizer. The average utilization coefficients of fertilizers by the crop were 42%-87%, 0%-3%, 5%-15% respectively for N, P and K. It was higher with film-covering than that without covering, especially for the high fertilization treatment. Analysis of water samples collected for eight run-off events showed that, without film-covering, N, P and K average concentrations in the runoff waters with fertilizations were 27.72, 2.70 and 7.07 mg x L(-1), respectively. And they were reduced respectively by 39.54%, 28.05%, 43.74% with the film-covering. This can give significant benefits to the decrease of agricultural non-point source pollution and water eutrophication. PMID:20358842
[Reducing nutrients loss by plastic film covering chemical fertilizers].
Chen, Huo-jun; Wei, Ze-bin; Wu, Qi-tang; Zeng, Shu-cai
2010-03-01
With the low utilization rate of fertilizers by crop and the growing amount of fertilizer usage,the agricultural non-point source pollution in China is becoming more and more serious. The field experiments planting corns were conducted, in which the applied chemical fertilizers were recovered with plastic film to realize the separation of fertilizers from rain water. In the experiments, the influences of different fertilizing treatments on the growing and production of sweet corn were observed. The fertilizer utilization rate and the nutrient contents in surface run-off water with and without the film covering were also determined. Results showed that, with only 70% of the normal amount of fertilizers,the sweet corn could already get high yield under the experimental soil conditions. Soil analysis after corn crops showed that the amounts of available N, P and K in the soil increased obviously with the film-covering, and the decreasing order was: 100% fertilizers with film-covering > 70% fertilizers with film-covering > 100% fertilizers, 70% fertilizers > no fertilizer. The average utilization coefficients of fertilizers by the crop were 42%-87%, 0%-3%, 5%-15% respectively for N, P and K. It was higher with film-covering than that without covering, especially for the high fertilization treatment. Analysis of water samples collected for eight run-off events showed that, without film-covering, N, P and K average concentrations in the runoff waters with fertilizations were 27.72, 2.70 and 7.07 mg x L(-1), respectively. And they were reduced respectively by 39.54%, 28.05%, 43.74% with the film-covering. This can give significant benefits to the decrease of agricultural non-point source pollution and water eutrophication.
Aperture-Tolerant, Chemical-Based Methods to Reduce Channeling
Randall S. Seright
2007-09-30
This final technical progress report describes work performed from October 1, 2004, through May 16, 2007, for the project, 'Aperture-Tolerant, Chemical-Based Methods to Reduce Channeling'. We explored the potential of pore-filling gels for reducing excess water production from both fractured and unfractured production wells. Several gel formulations were identified that met the requirements--i.e., providing water residual resistance factors greater than 2,000 and ultimate oil residual resistance factors (F{sub rro}) of 2 or less. Significant oil throughput was required to achieve low F{sub rro} values, suggesting that gelant penetration into porous rock must be small (a few feet or less) for existing pore-filling gels to provide effective disproportionate permeability reduction. Compared with adsorbed polymers and weak gels, strong pore-filling gels can provide greater reliability and behavior that is insensitive to the initial rock permeability. Guidance is provided on where relative-permeability-modification/disproportionate-permeability-reduction treatments can be successfully applied for use in either oil or gas production wells. When properly designed and executed, these treatments can be successfully applied to a limited range of oilfield excessive-water-production problems. We examined whether gel rheology can explain behavior during extrusion through fractures. The rheology behavior of the gels tested showed a strong parallel to the results obtained from previous gel extrusion experiments. However, for a given aperture (fracture width or plate-plate separation), the pressure gradients measured during the gel extrusion experiments were much higher than anticipated from rheology measurements. Extensive experiments established that wall slip and first normal stress difference were not responsible for the pressure gradient discrepancy. To explain the discrepancy, we noted that the aperture for gel flow (for mobile gel wormholing through concentrated immobile
Evidence for shared genetic risk between ADHD symptoms and reduced mathematics ability: a twin study
Greven, Corina U.; Kovas, Yulia; Willcutt, Erik G.; Petrill, Stephen A.; Plomin, Robert
2013-01-01
Background Attention-deficit/hyperactivity disorder (ADHD) symptoms and mathematics ability are associated, but little is known about the genetic and environmental influences underlying this association. Methods Data came from more than 6,000 12-year-old twin pairs from the U.K. population-representative Twins Early Development Study. Parents rated each twin’s behaviour using a DSM-IV-based 18-item questionnaire of inattentive and hyperactive-impulsive ADHD symptoms. Mathematics tests based on the U.K. National Curriculum were completed by each twin. The twins also completed standardised tests of reading and general cognitive ability. Multivariate twin model fitting was applied. Results Inattentive and hyperactive-impulsive ADHD symptoms were highly heritable (67% and 73%, respectively). Mathematics ability was moderately heritable (46%). Mathematics ability and inattentiveness showed a significantly greater phenotypic correlation (rp=−0.26) and genetic correlation (rA=−0.41) than mathematics ability and hyperactivity-impulsivity (rp=−0.18; rA=−0.22). The genetic correlation between inattentiveness and mathematics ability was largely independent from hyperactivity-impulsivity, and was only partially accounted for by genetic influences related to reading and general cognitive ability. Conclusions Results revealed the novel finding that mathematics ability shows significantly stronger phenotypic and genetic associations with inattentiveness than with hyperactivity-impulsivity. Genetic associations between inattentiveness and mathematics ability could only partially be accounted for by hyperactivity-impulsivity, reading and general cognitive ability. Results suggest that mathematics ability is associated with ADHD symptoms largely because it shares genetic risk factors with inattentiveness, and provide further evidence for considering inattentiveness and hyperactivity-impulsivity separately. DNA markers for ADHD symptoms (especially inattentiveness) may also
Mathematical modeling in chemical engineering: from lab-scale to field studies
NASA Astrophysics Data System (ADS)
Pushpavanam, S.
2010-10-01
In this work we discuss four different problems where mathematical modeling gives us insight into system behavior. Most chemical plants are characterized by an upstream reactor coupled to a downstream separator unit via a recycle stream. The steady state behavior of a representative system is analyzed for the maximum number of steady states which are admissible Different flow regimes in single and two phase-flows are discussed with a view to understanding mixing phenomena in micro-fluidics. In single phase flows Deans vortices cause mixing while in two phase slugs the mixing is caused by internal circulations. Bubble column reactors are heterogeneous systems characterized by turbulent flows. Flow fields are measured experimentally using PIV and these can be validated using computational fluid dynamics. In the context of Air Quality monitoring, field data are analyzed using statistical methods. This is used to predict source contributions to air quality levels in a region and to evaluate different control options.
NASA Astrophysics Data System (ADS)
Chirskaia, Natalia; Novikov, Lev; Voronina, Ekaterina
2016-07-01
Atomic oxygen (AO) of the upper atmosphere is one of the most important space factors that can cause degradation of spacecraft surface. In our previous mathematical model the Monte Carlo method and the "large particles" approximation were used for simulating processes of polymer etching under the influence of AO [1]. The interaction of enlarged AO particles with the polymer was described in terms of probabilities of reactions such as etching of polymer and specular and diffuse scattering of the AO particles on polymer. The effects of atomic oxygen on protected polymers and microfiller containing composites were simulated. The simulation results were in quite good agreement with the results of laboratory experiments on magnetoplasmadynamic accelerator of the oxygen plasma of SINP MSU [2]. In this paper we present a new model that describes the reactions of AO interactions with polymeric materials in more detail. Reactions of formation and further emission of chemical compounds such as CO, CO _{2}, H _{2}O, etc. cause the modification of the chemical composition of the polymer and change the probabilities of its consequent interaction with the AO. The simulation results are compared with the results of previous simulation and with the results of laboratory experiments. The reasons for the differences between the results of natural experiments on spacecraft, laboratory experiments and simulations are discussed. N. Chirskaya, M. Samokhina, Computer modeling of polymer structures degradation under the atomic oxygen exposure, WDS'12 Proceedings of Contributed Papers: Part III - Physics, Matfyzpress Prague, 2012, pp. 30-35. E. Voronina, L. Novikov, V. Chernik, N. Chirskaya, K. Vernigorov, G. Bondarenko, and A. Gaidar, Mathematical and experimental simulation of impact of atomic oxygen of the earth's upper atmosphere on nanostructures and polymer composites, Inorganic Materials: Applied Research, 2012, vol. 3, no. 2, pp. 95-101.
Novel in vitro and mathematical models for the prediction of chemical toxicity
Shipley, Rebecca; Ellis, Marianne J.; Webb, Steve; Ward, John; Gardner, Iain; Creton, Stuart
2013-01-01
The focus of much scientific and medical research is directed towards understanding the disease process and defining therapeutic intervention strategies. The scientific basis of drug safety is very complex and currently remains poorly understood, despite the fact that adverse drug reactions (ADRs) are a major health concern and a serious impediment to development of new medicines. Toxicity issues account for ∼21% drug attrition during drug development and safety testing strategies require considerable animal use. Mechanistic relationships between drug plasma levels and molecular/cellular events that culminate in whole organ toxicity underpins development of novel safety assessment strategies. Current in vitro test systems are poorly predictive of toxicity of chemicals entering the systemic circulation, particularly to the liver. Such systems fall short because of (1) the physiological gap between cells currently used and human hepatocytes existing in their native state, (2) the lack of physiological integration with other cells/systems within organs, required to amplify the initial toxicological lesion into overt toxicity, (3) the inability to assess how low level cell damage induced by chemicals may develop into overt organ toxicity in a minority of patients, (4) lack of consideration of systemic effects. Reproduction of centrilobular and periportal hepatocyte phenotypes in in vitro culture is crucial for sensitive detection of cellular stress. Hepatocyte metabolism/phenotype is dependent on cell position along the liver lobule, with corresponding differences in exposure to substrate, oxygen and hormone gradients. Application of bioartificial liver (BAL) technology can encompass in vitro predictive toxicity testing with enhanced sensitivity and improved mechanistic understanding. Combining this technology with mechanistic mathematical models describing intracellular metabolism, fluid-flow, substrate, hormone and nutrient distribution provides the opportunity to
Gage of 6.5 per cent Si-Fe sheet is chemically reduced
NASA Technical Reports Server (NTRS)
Goldman, A.; Pavlovic, D. M.
1966-01-01
Chemical milling process aids the production of 6.5 percent silicon-iron soft magnetic-alloy sheets to very thin gages. Following conventional rolling to safe gage limits, the material is chemically reduced to the desired gage.
ERIC Educational Resources Information Center
Butkovich, Nancy J.
2015-01-01
Doctoral candidates may request short-term embargoes on the release of their dissertations in order to apply for patents. This study examines how often inventions described in dissertations in chemical engineering, chemistry, physics, and mathematics are converted into U.S. patent applications, as well as the relationship between dissertation…
Reducing disorder in graphene nanoribbons by chemical edge modification
Dauber, J.; Terrés, B.; Volk, C.; Stampfer, C.; Trellenkamp, S.
2014-02-24
We present electronic transport measurements on etched graphene nanoribbons on silicon dioxide before and after a short hydrofluoric acid (HF) treatment. We report on changes in the transport properties, in particular, in terms of a decreasing transport gap and a reduced doping level after HF dipping. Interestingly, the effective energy gap is nearly unaffected by the HF treatment. Additional measurements on a graphene nanoribbon with lateral graphene gates support strong indications that the HF significantly modifies the edges of the investigated nanoribbons leading to a significantly reduced disorder potential in these graphene nanostructures.
Pyrazine-derived disulfide-reducing agent for chemical biology.
Lukesh, John C; Wallin, Kelly K; Raines, Ronald T
2014-08-28
For fifty years, dithiothreitol (DTT) has been the preferred reagent for the reduction of disulfide bonds in proteins and other biomolecules. Herein we report on the synthesis and characterization of 2,3-bis(mercaptomethyl)pyrazine (BMMP), a readily accessible disulfide-reducing agent with reactivity under biological conditions that is markedly superior to DTT and other known reagents.
Mathematics anxiety reduces default mode network deactivation in response to numerical tasks.
Pletzer, Belinda; Kronbichler, Martin; Nuerk, Hans-Christoph; Kerschbaum, Hubert H
2015-01-01
Mathematics anxiety is negatively related to mathematics performance, thereby threatening the professional success. Preoccupation with the emotional content of the stimuli may consume working memory resources, which may be reflected in decreased deactivation of areas associated with the default mode network (DMN) activated during self-referential and emotional processing. The common problem is that math anxiety is usually associated with poor math performance, so that any group differences are difficult to interpret. Here we compared the BOLD-response of 18 participants with high (HMAs) and 18 participants with low mathematics anxiety (LMAs) matched for their mathematical performance to two numerical tasks (number comparison, number bisection). During both tasks, we found stronger deactivation within the DMN in LMAs compared to HMAs, while BOLD-response in task-related activation areas did not differ between HMAs and LMAs. The difference in DMN deactivation between the HMA and LMA group was more pronounced in stimuli with additional requirement on inhibitory functions, but did not differ between number magnitude processing and arithmetic fact retrieval.
Evidence for Shared Genetic Risk between ADHD Symptoms and Reduced Mathematics Ability: A Twin Study
ERIC Educational Resources Information Center
Greven, Corina U.; Kovas, Yulia; Willcutt, Erik G.; Petrill, Stephen A.; Plomin, Robert
2013-01-01
Background: Attention-deficit/hyperactivity disorder (ADHD) symptoms and mathematics ability are associated, but little is known about the genetic and environmental influences underlying this association. Methods: Data came from more than 6,000 twelve-year-old twin pairs from the UK population-representative Twins Early Development Study. Parents…
Reduce, Reuse, Recycle: Resources and Strategies for the Use of Writing Projects in Mathematics
ERIC Educational Resources Information Center
Latulippe, Joe; Latulippe, Christine
2014-01-01
As an often recommended but under-utilized pedagogical strategy, writing in mathematics has many benefits for students. However, creating and grading worthwhile writing projects can be more time-consuming than utilizing more traditional forms of assessment. This paper provides a concrete example of a writing project prompt, questions, directions,…
Mathematics anxiety reduces default mode network deactivation in response to numerical tasks
Pletzer, Belinda; Kronbichler, Martin; Nuerk, Hans-Christoph; Kerschbaum, Hubert H.
2015-01-01
Mathematics anxiety is negatively related to mathematics performance, thereby threatening the professional success. Preoccupation with the emotional content of the stimuli may consume working memory resources, which may be reflected in decreased deactivation of areas associated with the default mode network (DMN) activated during self-referential and emotional processing. The common problem is that math anxiety is usually associated with poor math performance, so that any group differences are difficult to interpret. Here we compared the BOLD-response of 18 participants with high (HMAs) and 18 participants with low mathematics anxiety (LMAs) matched for their mathematical performance to two numerical tasks (number comparison, number bisection). During both tasks, we found stronger deactivation within the DMN in LMAs compared to HMAs, while BOLD-response in task-related activation areas did not differ between HMAs and LMAs. The difference in DMN deactivation between the HMA and LMA group was more pronounced in stimuli with additional requirement on inhibitory functions, but did not differ between number magnitude processing and arithmetic fact retrieval. PMID:25954179
Federal Register 2010, 2011, 2012, 2013, 2014
2011-07-13
... chemical reaction, including any associated processes (e.g., purification, separation, extraction... Impact of Reducing the Mixture Concentration Threshold for Commercial Schedule 2A Chemical Activities Under the Chemical Weapons Convention Regulations; Proposed Rule #0;#0;Federal Register / Vol. 76 ,...
Federal Register 2010, 2011, 2012, 2013, 2014
2011-07-13
... within the same plant through chemical reaction, including any associated processes (e.g., purification... Reducing the Mixture Concentration Threshold for Commercial Schedule 3 Chemical Activities Under the Chemical Weapons Convention Regulations; Proposed Rule #0;#0;Federal Register / Vol. 76 , No....
Chemical characterization of dissolvable tobacco products promoted to reduce harm.
Rainey, Christina L; Conder, Paige A; Goodpaster, John V
2011-03-23
In 2009, the R. J. Reynolds Tobacco Co. released a line of dissolvable tobacco products that are marketed as an alternative to smoking in places where smoking is prohibited. These products are currently available in Indianapolis, IN, Columbus, OH, and Portland, OR. This paper describes the chemical characterization of four such products by gas chromatography-mass spectrometry (GC-MS). The dissolvable tobacco products were extracted and prepared by ultrasonic extraction using acetone, trimethylsilyl derivatization, and headspace solid phase microextraction (SPME). The following compounds were identified in the dissolvables using either ultrasonic extractions or trimethylsilyl derivatization: nicotine, ethyl citrate, palmitic acid, stearic acid, sorbitol, glycerol, and xylitol. The following compounds were identified in the dissolvables using headspace SPME: nicotine, ethyl citrate, cinnamaldehyde, coumarin, vanillin, and carvone. With the exception of nicotine, the compounds identified thus far in the dissolvables are either flavoring compounds or binders. The concentration of free nicotine in the dissolvables was determined from the Henderson-Hasselbalch equation and by measuring the pH and nicotine concentration by GC-MS. The results presented here are the first to reveal the complexity of dissolvable tobacco products and may be used to assess potential oral health effects.
Prospects for managing turfgrass pests with reduced chemical inputs.
Held, David W; Potter, Daniel A
2012-01-01
Turfgrass culture, a multibillion dollar industry in the United States, poses unique challenges for integrated pest management. Why insect control on lawns, golf courses, and sport fields remains insecticide-driven, and how entomological research and extension can best support nascent initiatives in environmental golf and sustainable lawn care are explored. High standards for aesthetics and playability, prevailing business models, risk management-driven control decisions, and difficulty in predicting pest outbreaks fuel present reliance on preventive insecticides. New insights into pest biology, sampling methodology, microbial insecticides, plant resistance, and conservation biological control are reviewed. Those gains, and innovations in reduced-risk insecticides, should make it possible to begin constructing holistic management plans for key turfgrass pests. Nurturing the public's interest in wildlife habitat preservation, including beneficial insects, may be one means to change aesthetic perceptions and gain leeway for implementing integrated pest management practices that lend stability to turfgrass settings.
Prospects for managing turfgrass pests with reduced chemical inputs.
Held, David W; Potter, Daniel A
2012-01-01
Turfgrass culture, a multibillion dollar industry in the United States, poses unique challenges for integrated pest management. Why insect control on lawns, golf courses, and sport fields remains insecticide-driven, and how entomological research and extension can best support nascent initiatives in environmental golf and sustainable lawn care are explored. High standards for aesthetics and playability, prevailing business models, risk management-driven control decisions, and difficulty in predicting pest outbreaks fuel present reliance on preventive insecticides. New insights into pest biology, sampling methodology, microbial insecticides, plant resistance, and conservation biological control are reviewed. Those gains, and innovations in reduced-risk insecticides, should make it possible to begin constructing holistic management plans for key turfgrass pests. Nurturing the public's interest in wildlife habitat preservation, including beneficial insects, may be one means to change aesthetic perceptions and gain leeway for implementing integrated pest management practices that lend stability to turfgrass settings. PMID:21910640
Botrytis infection warnings in strawberry: reduced enhanced chemical control.
Van Laer, S; Hauke, K; Meesters, P; Creemers, P
2005-01-01
The fungal pathogen Botrytis cinerea is the causal agent of grey mould, the most important fungal fruit rot disease in strawberry in Europe. Currently disease control for grey mould is based on preventive spraying every five to seven days during flowering and harvest. Replacing preventive spraying with applications based on infection warnings can optimize performance and reduce the amount of sprays needed. Success of this approach will depend on the accuracy of the model used to predict disease outbreak. For this reason three infection models (BOTEM, BoWaS, DSS-Italy) were evaluated during the growth seasons of 2003 and 2004. The experiments included June bearing, retarded June bearing and ever bearing strawberries. In all experiments the use of infection models leaded to a reduced number of fungicide applications. However the efficacy of the different models towards the control of B. cinerea also decreased compared to the efficacy obtained with a standard 7 day schedule. Best results were obtained with BOTEM, developed by HRI (Horticultural Research International, East-Malling, UK): 17-60% reduction in fungicide use and an efficacy between 66-93 depending on the growth season, culture practice and the fungicides used. Compared with routine preventive spraying, the Botrytis fruit rot percentage is slightly higher. A higher efficacy with Botrytis infection warnings can only be obtained if infection warnings change from curative to preventive. A retroactive evaluation of a preventive warning system was included. Making use of the 48h weather forecasts supplied by the Royal Meteorological Institute of Belgium (KMI) based on ALADIN for the region of Haspengouw, it was possible to replace 30 up to 100% of the curative application by preventive spraying depending on the experiment and the threshold set for the preventive model.
Ambrosi, Adriano; Chua, Chun Kiang; Khezri, Bahareh; Sofer, Zdeněk; Webster, Richard D.; Pumera, Martin
2012-01-01
Graphene-related materials are in the forefront of nanomaterial research. One of the most common ways to prepare graphenes is to oxidize graphite (natural or synthetic) to graphite oxide and exfoliate it to graphene oxide with consequent chemical reduction to chemically reduced graphene. Here, we show that both natural and synthetic graphite contain a large amount of metallic impurities that persist in the samples of graphite oxide after the oxidative treatment, and chemically reduced graphene after the chemical reduction. We demonstrate that, despite a substantial elimination during the oxidative treatment of graphite samples, a significant amount of impurities associated to the chemically reduced graphene materials still remain and alter their electrochemical properties dramatically. We propose a method for the purification of graphenes based on thermal treatment at 1,000 °C in chlorine atmosphere to reduce the effect of such impurities on the electrochemical properties. Our findings have important implications on the whole field of graphene research. PMID:22826262
Ambrosi, Adriano; Chua, Chun Kiang; Khezri, Bahareh; Sofer, Zdeněk; Webster, Richard D; Pumera, Martin
2012-08-01
Graphene-related materials are in the forefront of nanomaterial research. One of the most common ways to prepare graphenes is to oxidize graphite (natural or synthetic) to graphite oxide and exfoliate it to graphene oxide with consequent chemical reduction to chemically reduced graphene. Here, we show that both natural and synthetic graphite contain a large amount of metallic impurities that persist in the samples of graphite oxide after the oxidative treatment, and chemically reduced graphene after the chemical reduction. We demonstrate that, despite a substantial elimination during the oxidative treatment of graphite samples, a significant amount of impurities associated to the chemically reduced graphene materials still remain and alter their electrochemical properties dramatically. We propose a method for the purification of graphenes based on thermal treatment at 1,000 °C in chlorine atmosphere to reduce the effect of such impurities on the electrochemical properties. Our findings have important implications on the whole field of graphene research.
Zaitseva, N. V.; Kiryanov, D. A.; Lanin, D. V.; Chigvintsev, V. M.
2014-01-01
The concept of the triad regulatory metasystem, which includes the neuroendocrine and immune regulation systems, is currently generally accepted. Changes occurring in each of the regulatory systems in response to the impact of technogenic chemical factors are also well known. This paper presents mathematical models of the immune and neuroendocrine system functioning, using the interaction between these systems in response to bacterial invasion as an example, and changes in their performance under exposure to chemical factors, taking into account the stage of functional disorders in a producing organ, using the performance of the bone marrow as an example. PMID:24872840
2014-01-01
Background When asked to solve mathematical problems, some people experience anxiety and threat, which can lead to impaired mathematical performance (Curr Dir Psychol Sci 11:181–185, 2002). The present studies investigated the link between mathematical anxiety and performance on the cognitive reflection test (CRT; J Econ Perspect 19:25–42, 2005). The CRT is a measure of a person’s ability to resist intuitive response tendencies, and it correlates strongly with important real-life outcomes, such as time preferences, risk-taking, and rational thinking. Methods In Experiments 1 and 2 the relationships between maths anxiety, mathematical knowledge/mathematical achievement, test anxiety and cognitive reflection were analysed using mediation analyses. Experiment 3 included a manipulation of working memory load. The effects of anxiety and working memory load were analysed using ANOVAs. Results Our experiments with university students (Experiments 1 and 3) and secondary school students (Experiment 2) demonstrated that mathematical anxiety was a significant predictor of cognitive reflection, even after controlling for the effects of general mathematical knowledge (in Experiment 1), school mathematical achievement (in Experiment 2) and test anxiety (in Experiments 1–3). Furthermore, Experiment 3 showed that mathematical anxiety and burdening working memory resources with a secondary task had similar effects on cognitive reflection. Conclusions Given earlier findings that showed a close link between cognitive reflection, unbiased decisions and rationality, our results suggest that mathematical anxiety might be negatively related to individuals’ ability to make advantageous choices and good decisions. PMID:25179230
Mathematical Modelling on Chemically Reacting Boundary Type Flow under Reduced Gravity Conditions
NASA Astrophysics Data System (ADS)
Wang, Hui Ying; Herviou, Thomas
2015-01-01
A numerical study was performed to give a quantitative description of a heavily sooting, non-premixed laminar flame established in a shear boundary layer in microgravity. The competition between fuel pyrolysis rate, radiation loss due to soot formation and oxygen- side diffusion creates a number of unusual phenomena. A three-dimensional, laminar diffusion flame over plate in low-speed concurrent flow was formulated and solved. The model consists of full Navier-Stokes equations for mass, momentum, energy and species. Gas radiation associated with soot formation is included. The PAH inception model, which is based on the formation of two and three-ringed aromatic species, reproduces correctly the measured soot from a laminar ethylene diffusion flame. The flame standoff distance is beyond the boundary layer thickness, while soot resides always within the boundary layer. The fraction of the total energy released by the flame to the surface increases with a rise of pyrolysis rate due to increase in the flame volume. The zone of the high heat flux increases noticeably when the flame becomes most obviously dual on the cross-stream section due to development of the counter-rotating vortex.
Aceves, S M; Martinez-Frias, J; Flowers, D; Smith, J R; Dibble, R; Chen, J Y
2002-08-12
This paper shows how a computer can systematically remove non-essential chemical reactions from a large chemical kinetic mechanism. The computer removes the reactions based upon a single solution using a detailed mechanism. The resulting reduced chemical mechanism produces similar numerical predictions significantly faster than predictions that use the detailed mechanism. Specifically, a reduced chemical kinetics mechanism for iso-octane has been derived from a detailed mechanism by eliminating unimportant reaction steps and species. The reduced mechanism has been developed for the specific purpose of fast and accurate prediction of ignition timing in an HCCI engine. The reduced mechanism contains 199 species and 383 reactions, while the detailed mechanism contains 859 species and 3606 reactions. Both mechanisms have been used in numerical simulation of HCCI combustion. The simulations show that the reduced mechanism predicts pressure traces and heat release with good accuracy, similar to the accuracy obtained with the detailed mechanism. As may be expected, emissions of hydrocarbon and carbon monoxide are not as well predicted with the reduced mechanism as with the detailed mechanism, since the reduced mechanism was targeted for predicting HCCI ignition and not HC and CO emissions. Considering that the reduced mechanism requires about 25 times less computational time than the detailed mechanism (2 hours vs. 2 days), the ability to automatically generate a problem specific reduced mechanism is an important new tool for combustion research in general.
McMahon, A.J.; Smith, P.S.; Lee, Y.
1997-08-01
Water soluble drag reducer chemicals have enabled significant increases in flow rates in many oilfield water injection systems. In some cases there is concern that this could lead to increased oxygen corrosion whenever the dissolved oxygen concentration strays above a typical injection target such as 20 ppb O{sub 2}. The effect of a chemical drag reducer on oxygen corrosion of carbon steel was examined in a large scale flow loop simulating a sea water injection line. Drag reduction (up to 48%) matched corrosion reduction (up to 39%). This means that drag reducer has a self compensating effect on oxygen corrosion: it permits higher flow rates without increasing the oxygen corrosion rate.
ERIC Educational Resources Information Center
Curtright, Robert; Emry, Randall; Heaton, Ruth M.; Markwell, John
2004-01-01
We describe a simple undergraduate exercise involving the titration of a weak acid by a strong base using a pH meter and a micropipette. Students then use their data and carry out graphical analyses with a spreadsheet. The analyses involve using mathematical concepts such as first-derivative and semi-log plots and provide an opportunity for…
NASA Astrophysics Data System (ADS)
Umansky, A. A.; Golovatenko, A. V.; Kadykov, V. N.; Dumova, L. V.
2016-09-01
Using the device of the complex “Gleeble System 3800” the physical experimental studies of deformation resistance of chrome rail steel at different thermo-mechanical deformation parameters were carried out. On the basis of mathematical processing of experimental data the statistical model of dependence of the rail steel deformation resistance on the simultaneous influence of deformation degree, rate and temperature, as well as the steel chemical composition, was developed. The nature of influence of deformation parameters and the content of chemical elements in steel on its resistance to plastic deformation is scientifically substantiated. Verification of the adequacy of the proposed model by the comparative analysis of the calculated and actual rolling forces during passes in the universal rail-and-structural steel mill JSC “EVRAZ Consolidated West Siberian Metallurgical Plant” (“EVRAZ ZSMK”) showed the possibility of its use for development and improvement of new modes of rails rolling.
Mathematical Analysis of Space Radiator Segmenting for Increased Reliability and Reduced Mass
NASA Technical Reports Server (NTRS)
Juhasz, Albert J.
2001-01-01
Spacecraft for long duration deep space missions will need to be designed to survive micrometeoroid bombardment of their surfaces some of which may actually be punctured. To avoid loss of the entire mission the damage due to such punctures must be limited to small, localized areas. This is especially true for power system radiators, which necessarily feature large surface areas to reject heat at relatively low temperature to the space environment by thermal radiation. It may be intuitively obvious that if a space radiator is composed of a large number of independently operating segments, such as heat pipes, a random micrometeoroid puncture will result only in the loss of the punctured segment, and not the entire radiator. Due to the redundancy achieved by independently operating segments, the wall thickness and consequently the weight of such segments can be drastically reduced. Probability theory is used to estimate the magnitude of such weight reductions as the number of segments is increased. An analysis of relevant parameter values required for minimum mass segmented radiators is also included.
Li, Wei; Cochell, Thomas; Manthiram, Arumugam
2013-01-01
Metallic aluminum (Al) is of interest as a reducing agent because of its low standard reduction potential. However, its surface is invariably covered with a dense aluminum oxide film, which prevents its effective use as a reducing agent in wet-chemical synthesis. Pitting corrosion, known as an undesired reaction destroying Al and is enhanced by anions such as F−, Cl−, and Br− in aqueous solutions, is applied here for the first time to activate Al as a reducing agent for wet-chemical synthesis of a diverse array of metals and alloys. Specifically, we demonstrate the synthesis of highly dispersed palladium nanoparticles on carbon black with stabilizers and the intermetallic Cu2Sb/C, which are promising candidates, respectively, for fuel cell catalysts and lithium-ion battery anodes. Atomic hydrogen, an intermediate during the pitting corrosion of Al in protonic solvents (e.g., water and ethylene glycol), is validated as the actual reducing agent. PMID:23390579
Li, Wei; Cochell, Thomas; Manthiram, Arumugam
2013-01-01
Metallic aluminum (Al) is of interest as a reducing agent because of its low standard reduction potential. However, its surface is invariably covered with a dense aluminum oxide film, which prevents its effective use as a reducing agent in wet-chemical synthesis. Pitting corrosion, known as an undesired reaction destroying Al and is enhanced by anions such as F⁻, Cl⁻, and Br⁻ in aqueous solutions, is applied here for the first time to activate Al as a reducing agent for wet-chemical synthesis of a diverse array of metals and alloys. Specifically, we demonstrate the synthesis of highly dispersed palladium nanoparticles on carbon black with stabilizers and the intermetallic Cu₂Sb/C, which are promising candidates, respectively, for fuel cell catalysts and lithium-ion battery anodes. Atomic hydrogen, an intermediate during the pitting corrosion of Al in protonic solvents (e.g., water and ethylene glycol), is validated as the actual reducing agent.
none,
2000-11-01
Nalco Chemical Company is constantly seeking ways to improve steam system performance. At Nalco's Clearing Plant in Bedford Park, Illinois, changes in some of the plants processes led personnel to evaluate the feasibility of reducing the steam header pressure. The team decided to incrementally decrease header pressure while monitoring the effects of this change on system performance. The pressure was reduced twice, and each time the system was carefully monitored to ensure there was no detrimental impact on system operation.
There is increasing evidence that exposure to endocrine disrupting chemicals (EDCs) in the environment can induce adverse effects on reproduction and development in both humans and wildlife, mediated through hormonal disturbances.
Connors, Kristin A; Voutchkova-Kostal, Adelina M; Kostal, Jakub; Anastas, Paul; Zimmerman, Julie B; Brooks, Bryan W
2014-08-01
Basic toxicological information is lacking for the majority of industrial chemicals. In addition to increasing empirical toxicity data through additional testing, prospective computational approaches to drug development aim to serve as a rational basis for the design of chemicals with reduced toxicity. Recent work has resulted in the derivation of a "rule of 2," wherein chemicals with an octanol-water partition coefficient (log P) less than 2 and a difference between the lowest unoccupied molecular orbital and the highest occupied molecular orbital (ΔE) greater than 9 (log P<2 and ΔE >9 eV) are predicted to be 4 to 5 times less likely to elicit acute or chronic toxicity to model aquatic organisms. The present study examines potential reduction of aquatic toxicity hazards from industrial chemicals if these 2 molecular design guidelines were employed. Probabilistic hazard assessment approaches were used to model the likelihood of encountering industrial chemicals exceeding toxicological categories of concern both with and without the rule of 2. Modeling predicted that utilization of these molecular design guidelines for log P and ΔE would appreciably decrease the number of chemicals that would be designated to be of "high" and "very high" concern for acute and chronic toxicity to standard model aquatic organisms and end points as defined by the US Environmental Protection Agency. For example, 14.5% of chemicals were categorized as having high and very high acute toxicity to the fathead minnow model, whereas only 3.3% of chemicals conforming to the design guidelines were predicted to be in these categories. Considerations of specific chemical classes (e.g., aldehydes), chemical attributes (e.g., ionization), and adverse outcome pathways in representative species (e.g., receptor-mediated responses) could be used to derive future property guidelines for broader classes of contaminants.
NASA Technical Reports Server (NTRS)
Goussis, D. A.; Lam, S. H.; Gnoffo, P. A.
1990-01-01
The Computational Singular Perturbation CSP methods is employed (1) in the modeling of a homogeneous isothermal reacting system and (2) in the numerical simulation of the chemical reactions in a hypersonic flowfield. Reduced and simplified mechanisms are constructed. The solutions obtained on the basis of these approximate mechanisms are shown to be in very good agreement with the exact solution based on the full mechanism. Physically meaningful approximations are derived. It is demonstrated that the deduction of these approximations from CSP is independent of the complexity of the problem and requires no intuition or experience in chemical kinetics.
NASA Astrophysics Data System (ADS)
Kehayias, Christopher E.; MacNaughton, Samuel; Sonkusale, Sameer; Staii, Cristian
2013-06-01
Reduced graphene oxide (RGO) is an electronically hybrid material that displays remarkable chemical sensing properties. Here, we present a quantitative analysis of the chemical gating effects in RGO-based chemical sensors. The gas sensing devices are patterned in a field-effect transistor geometry, by dielectrophoretic assembly of RGO platelets between gold electrodes deposited on SiO2/Si substrates. We show that these sensors display highly selective and reversible responses to the measured analytes, as well as fast response and recovery times (tens of seconds). We use combined electronic transport/Kelvin probe microscopy measurements to quantify the amount of charge transferred to RGO due to chemical doping when the device is exposed to electron-acceptor (acetone) and electron-donor (ammonia) analytes. We demonstrate that this method allows us to obtain high-resolution maps of the surface potential and local charge distribution both before and after chemical doping, to identify local gate-susceptible areas on the RGO surface, and to directly extract the contact resistance between the RGO and the metallic electrodes. The method presented is general, suggesting that these results have important implications for building graphene and other nanomaterial-based chemical sensors.
Reducing health risk assigned to organic emissions from a chemical weapons incinerator.
Laman, David M; Weiler, B Douglas; Skeen, Rodney S
2013-03-01
Organic emissions from a chemical weapons incinerator have been characterized with an improved set of analytical methods to reduce the human health risk assigned to operations of the facility. A gas chromatography/mass selective detection method with substantially reduced detection limits has been used in conjunction with scanning electron microscopy/energy dispersive X-ray spectrometry and Fourier transform infrared microscopy to improve the speciation of semi-volatile and non-volatile organics emitted from the incinerator. The reduced detection limits have allowed a significant reduction in the assumed polycyclic aromatic hydrocarbon (PAH) and aminobiphenyl (ABP) emission rates used as inputs to the human health risk assessment for the incinerator. A mean factor of 17 decrease in assigned human health risk is realized for six common local exposure scenarios as a result of the reduced PAH and ABP detection limits.
ERIC Educational Resources Information Center
Gultepe, Nejla; Yalcin Celik, Ayse; Kilic, Ziya
2013-01-01
The purpose of the study was to examine the effects of students' conceptual understanding of chemical concepts and mathematical processing skills on algorithmic problem-solving skills. The sample (N = 554) included grades 9, 10, and 11 students in Turkey. Data were collected using the instrument "MPC Test" and with interviews. The…
ERIC Educational Resources Information Center
Grimaldi, Ralph P.
This material was developed to provide an application of matrix mathematics in chemistry, and to show the concepts of linear independence and dependence in vector spaces of dimensions greater than three in a concrete setting. The techniques presented are not intended to be considered as replacements for such chemical methods as oxidation-reduction…
Singh, Dileep; Wagh, Arun S.; Jeong, Seung-Young
2000-01-01
Known phosphate ceramic formulations are improved and the ability to produce iron-based phosphate ceramic systems is enabled by the addition of an oxidizing or reducing step during the acid-base reactions that form the phosphate ceramic products. The additives allow control of the rate of the acid-base reactions and concomitant heat generation. In an alternate embodiment, waste containing metal anions are stabilized in phosphate ceramic products by the addition of a reducing agent to the phosphate ceramic mixture. The reduced metal ions are more stable and/or reactive with the phosphate ions, resulting in the formation of insoluble metal species within the phosphate ceramic matrix, such that the resulting chemically bonded phosphate ceramic product has greater leach resistance.
Singh, Dileep; Wagh, Arun S.; Jeong, Seung-Young
1999-05-05
Known phosphate ceramic formulations are improved and the ability to produce iron-based phosphate ceramic systems is enabled by the addition of an oxidizing or reducing step during the acid-base reactions that form the phosphate ceramic products. The additives allow control of the rate of the acid-base reactions and concomitant heat generation. In an alternate embodiment, waste containing metal anions is stabilized in phosphate ceramic products by the addition of a reducing agent to the phosphate ceramic mixture. The reduced metal ions are more stable and/or reactive with the phosphate ions, resulting in the formation of insoluble metal species within the phosphate ceramic matrix, such that the resulting chemically bonded phosphate ceramic product has greater leach resistance.
Rational application of chemicals in response to oil spills may reduce environmental damage.
Tamis, Jacqueline E; Jongbloed, Ruud H; Karman, Chris C; Koops, Wierd; Murk, Albertinka J
2012-04-01
Oil spills, for example those due to tanker collisions and groundings or platform accidents, can have huge adverse impacts on marine systems. The impact of an oil spill at sea depends on a number of factors, such as spill volume, type of oil spilled, weather conditions, and proximity to environmentally, economically, or socially sensitive areas. Oil spilled at sea threatens marine organisms, whole ecosystems, and economic resources in the immediate vicinity, such as fisheries, aquaculture, recreation, and tourism. Adequate response to any oil spill to minimize damage is therefore of great importance. The common response to an oil spill is to remove all visible oil from the water surface, either mechanically or by using chemicals to disperse the oil into the water column to biodegrade. This is not always the most suitable response to an oil spill, as the chemical application itself may also have adverse effects, or no response may be needed. In this article we discuss advantages and disadvantages of using chemical treatments to reduce the impact of an oil spill in relation to the conditions of the spill. The main characteristics of chemical treatment agents are discussed and presented within the context of a basic decision support scheme.
NASA Astrophysics Data System (ADS)
Ha, Tae-Jun; Lee, Alvin
2015-07-01
We report on the restoration of the electronic characteristics of waferscale chemical vapor deposition (CVD) monolayer graphene field-effect transistors (GFETs) by reducing the impurity concentration. An optimized electropolishing process on copper foils combined with carbon-fluorine encapsulation using a suitable amorphous fluoropolymer enables reducing the surface roughness of graphene and screening out interfacial impurity scattering, which leads to an improvement in all key device metrics. The conductivity at the Dirac point is substantially reduced, resulting in an increase in the on-off current ratio. In addition, the field-effect mobility increased from 1817 to 3918 cm2/V-s, the impurity concentration decreased from 1.1 × 1012 to 2.1 × 1011 cm-2 and the electron and hole transport became more symmetric. Significantly, favorable shifts toward zero voltage were observed in the Dirac point. We postulate that the smoother surface due to electropolishing and a pool of strong dipole-dipole moments in the flouropolymer coating provide a charge buffer that relaxes the fluctuation in the electron-hole puddles. We also investigate the long-term stability in GFETs encapsulated with fluoropolymer, which exhibit a high hydrophobicity that suppresses the chemical interaction with water molecules. [Figure not available: see fulltext.
Maiya, Rajani; McMahon, Thomas; Wang, Dan; Kanter, Benjamin; Gandhi, Dev; Chapman, Holly L; Miller, Jacklyn; Messing, Robert O
2016-08-01
Reducing expression or inhibiting translocation of protein kinase C epsilon (PKCε) prolongs ethanol intoxication and decreases ethanol consumption in mice. However, we do not know if this phenotype is due to reduced PKCε kinase activity or to impairment of kinase-independent functions. In this study, we used a chemical-genetic strategy to determine whether a potent and highly selective inhibitor of PKCε catalytic activity reduces ethanol consumption. We generated ATP analog-specific PKCε (AS-PKCε) knock-in mice harboring a point mutation in the ATP binding site of PKCε that renders the mutant kinase highly sensitive to inhibition by 1-tert-butyl-3-naphthalen-1-ylpyrazolo[3,4-d]pyrimidin-4-amine (1-NA-PP1). Systemically administered 1-NA-PP1 readily crossed the blood brain barrier and inhibited PKCε-mediated phosphorylation. 1-NA-PP1 reversibly reduced ethanol consumption by AS-PKCε mice but not by wild type mice lacking the AS-PKCε mutation. These results support the development of inhibitors of PKCε catalytic activity as a strategy to reduce ethanol consumption, and they demonstrate that the AS- PKCε mouse is a useful tool to study the role of PKCε in behavior. PMID:26947945
Wang, Yanyan; Zhang, Liling; Hu, Nantao; Wang, Ying; Zhang, Yafei; Zhou, Zhihua; Liu, Yanhua; Shen, Su; Peng, Changsi
2014-01-01
We present a useful ammonia gas sensor based on chemically reduced graphene oxide (rGO) sheets by self-assembly technique to create conductive networks between parallel Au electrodes. Negative graphene oxide (GO) sheets with large sizes (>10 μm) can be easily electrostatically attracted onto positive Au electrodes modified with cysteamine hydrochloride in aqueous solution. The assembled GO sheets on Au electrodes can be directly reduced into rGO sheets by hydrazine or pyrrole vapor and consequently provide the sensing devices based on self-assembled rGO sheets. Preliminary results, which have been presented on the detection of ammonia (NH3) gas using this facile and scalable fabrication method for practical devices, suggest that pyrrole-vapor-reduced rGO exhibits much better (more than 2.7 times with the concentration of NH3 at 50 ppm) response to NH3 than that of rGO reduced from hydrazine vapor. Furthermore, this novel gas sensor based on rGO reduced from pyrrole shows excellent responsive repeatability to NH3. Overall, the facile electrostatic self-assembly technique in aqueous solution facilitates device fabrication, the resultant self-assembled rGO-based sensing devices, with miniature, low-cost portable characteristics and outstanding sensing performances, which can ensure potential application in gas sensing fields.
Wang, Yanyan; Zhang, Liling; Hu, Nantao; Wang, Ying; Zhang, Yafei; Zhou, Zhihua; Liu, Yanhua; Shen, Su; Peng, Changsi
2014-01-01
We present a useful ammonia gas sensor based on chemically reduced graphene oxide (rGO) sheets by self-assembly technique to create conductive networks between parallel Au electrodes. Negative graphene oxide (GO) sheets with large sizes (>10 μm) can be easily electrostatically attracted onto positive Au electrodes modified with cysteamine hydrochloride in aqueous solution. The assembled GO sheets on Au electrodes can be directly reduced into rGO sheets by hydrazine or pyrrole vapor and consequently provide the sensing devices based on self-assembled rGO sheets. Preliminary results, which have been presented on the detection of ammonia (NH3) gas using this facile and scalable fabrication method for practical devices, suggest that pyrrole-vapor-reduced rGO exhibits much better (more than 2.7 times with the concentration of NH3 at 50 ppm) response to NH3 than that of rGO reduced from hydrazine vapor. Furthermore, this novel gas sensor based on rGO reduced from pyrrole shows excellent responsive repeatability to NH3. Overall, the facile electrostatic self-assembly technique in aqueous solution facilitates device fabrication, the resultant self-assembled rGO-based sensing devices, with miniature, low-cost portable characteristics and outstanding sensing performances, which can ensure potential application in gas sensing fields. PMID:24917701
NASA Astrophysics Data System (ADS)
Wang, Yanyan; Zhang, Liling; Hu, Nantao; Wang, Ying; Zhang, Yafei; Zhou, Zhihua; Liu, Yanhua; Shen, Su; Peng, Changsi
2014-05-01
We present a useful ammonia gas sensor based on chemically reduced graphene oxide (rGO) sheets by self-assembly technique to create conductive networks between parallel Au electrodes. Negative graphene oxide (GO) sheets with large sizes (>10 μm) can be easily electrostatically attracted onto positive Au electrodes modified with cysteamine hydrochloride in aqueous solution. The assembled GO sheets on Au electrodes can be directly reduced into rGO sheets by hydrazine or pyrrole vapor and consequently provide the sensing devices based on self-assembled rGO sheets. Preliminary results, which have been presented on the detection of ammonia (NH3) gas using this facile and scalable fabrication method for practical devices, suggest that pyrrole-vapor-reduced rGO exhibits much better (more than 2.7 times with the concentration of NH3 at 50 ppm) response to NH3 than that of rGO reduced from hydrazine vapor. Furthermore, this novel gas sensor based on rGO reduced from pyrrole shows excellent responsive repeatability to NH3. Overall, the facile electrostatic self-assembly technique in aqueous solution facilitates device fabrication, the resultant self-assembled rGO-based sensing devices, with miniature, low-cost portable characteristics and outstanding sensing performances, which can ensure potential application in gas sensing fields.
Shoman, Mai E; Aly, Omar M
2016-01-01
Nitroxyl (HNO), the one-electron reduced form of nitric oxide (NO), shows a distinct chemical and biological profile from that of NO. HNO is currently being viewed as a vasodilator and positive inotropic agent that can be used as a potential treatment for heart failure. The ability of HNO to react with thiols and thiol containing proteins is largely used to explain the possible biological actions of HNO. Herein, we summarize different aspects related to HNO including HNO donors, chemistry, biology, and methods used for its detection.
Shoman, Mai E.; Aly, Omar M.
2016-01-01
Nitroxyl (HNO), the one-electron reduced form of nitric oxide (NO), shows a distinct chemical and biological profile from that of NO. HNO is currently being viewed as a vasodilator and positive inotropic agent that can be used as a potential treatment for heart failure. The ability of HNO to react with thiols and thiol containing proteins is largely used to explain the possible biological actions of HNO. Herein, we summarize different aspects related to HNO including HNO donors, chemistry, biology, and methods used for its detection. PMID:26770654
Nabity, Paul D; Zavala, Jorge A; DeLucia, Evan H
2013-01-01
Herbivory initiates a shift in plant metabolism from growth to defence that may reduce fitness in the absence of further herbivory. However, the defence-induced changes in carbon assimilation that precede this reallocation in resources remain largely undetermined. This study characterized the response of photosynthesis to herbivore induction of jasmonic acid (JA)-related defences in Nicotiana attenuata to increase understanding of these mechanisms. It was hypothesized that JA-induced defences would immediately reduce the component processes of photosynthesis upon attack and was predicted that wild-type plants would suffer greater reductions in photosynthesis than plants lacking JA-induced defences. Gas exchange, chlorophyll fluorescence, and thermal spatial patterns were measured together with the production of defence-related metabolites after attack and through recovery. Herbivore damage immediately reduced electron transport and gas exchange in wild-type plants, and gas exchange remained suppressed for several days after attack. The sustained reductions in gas exchange occurred concurrently with increased defence metabolites in wild-type plants, whereas plants lacking JA-induced defences suffered minimal suppression in photosynthesis and no increase in defence metabolite production. This suppression in photosynthesis occurred only after sustained defence signalling and defence chemical mobilization, whereas a short bout of feeding damage only transiently altered components of photosynthesis. It was identified that lipoxygenase signalling interacted with photosynthetic electron transport and that the resulting JA-related metabolites reduced photosynthesis. These data represent a metabolic cost to mounting a chemical defence against herbivory and link defence-signalling networks to the differential effects of herbivory on photosynthesis in remaining leaf tissues in a time-dependent manner.
Revilla, Marta; Galán, Berta; Viguri, Javier R
2016-07-01
An integrated mathematical model is proposed for modelling a moving bed biofilm reactor (MBBR) for removal of chemical oxygen demand (COD) under aerobic conditions. The composite model combines the following: (i) a one-dimensional biofilm model, (ii) a bulk liquid model, and (iii) biological processes in the bulk liquid and biofilm considering the interactions among autotrophic, heterotrophic and predator microorganisms. Depending on the values for the soluble biodegradable COD loading rate (SCLR), the model takes into account a) the hydrolysis of slowly biodegradable compounds in the bulk liquid, and b) the growth of predator microorganisms in the bulk liquid and in the biofilm. The integration of the model and the SCLR allows a general description of the behaviour of COD removal by the MBBR under various conditions. The model is applied for two in-series MBBR wastewater plant from an integrated cellulose and viscose production and accurately describes the experimental concentrations of COD, total suspended solids (TSS), nitrogen and phosphorous obtained during 14 months working at different SCLRs and nutrient dosages. The representation of the microorganism group distribution in the biofilm and in the bulk liquid allow for verification of the presence of predator microorganisms in the second reactor under some operational conditions.
Packwood, D. M.; Reaves, K. T.; Federici, F. L.; Katzgraber, H. G.; Teizer, W.
2013-01-01
An open problem in applied mathematics is to predict interesting molecules that are realistic targets for chemical synthesis. In this paper, we use a spin Hamiltonian-type model to predict molecular magnets (MMs) with magnetic moments that are intrinsically robust under random shape deformations to the molecule. Using the concept of convergence in probability, we show that for MMs in which all spin centres lie in-plane and all spin centre interactions are ferromagnetic, the total spin of the molecule is a ‘weak topological invariant’ when the number of spin centres is sufficiently large. By weak topological invariant, we mean that the total spin of the molecule depends only upon the arrangement of spin centres in the molecule, and is unlikely to change under shape deformations to the molecule. Our calculations show that only between 20 and 50 spin centres are necessary for the total spin of these MMs to be a weak topological invariant. The robustness effect is particularly enhanced for two-dimensional ferromagnetic MMs that possess a small number of spin rings in the structure. PMID:24353469
Li, Yilin; Liu, Shaoyang; Cline, David; Chen, Shengshun; Wang, Yifen; Bell, Leonard N
2013-10-01
The effect of chemical pretreatments on the color and carotenoid content of yellow discolored channel catfish fillets was studied. The color and carotenoid content of the fillets were analyzed by the L*a*b* color system and high-performance liquid chromatography, respectively. Untreated fillets turned more yellow and darker after 12-d storage. Sodium bicarbonate had a beneficial effect on reducing the degree of yellowness, but the fillets still turned darker after storage. Sodium bisulfite gave the best results with fillets becoming less yellow and brighter after storage. Ascorbic acid, butylated hydroxyanisole, citric acid, and sodium metabisulfite were not successful at reducing the discoloration. The sum of carotenoid contents of untreated fillets decreased significantly (P < 0.05) during storage as compared to the fresh fillets. However, the sum of the carotenoid contents of fillets treated by various chemicals was not significantly (P > 0.05) different from the fresh or untreated fillets. The appearance of catfish fillets may be improved during storage by pretreating with sodium bisulfite. PMID:24025113
Ferromagnetism in chemically reduced LiNbO3 and LiTaO3 crystals
NASA Astrophysics Data System (ADS)
Yan, Tao; Ye, Ning; Xu, Liuwei; Sang, Yuanhua; Chen, Yanxue; Song, Wei; Long, Xifa; Wang, Jiyang; Liu, Hong
2016-05-01
The ferromagnetism of bulk LiNbO3 and LiTaO3 at room temperature was investigated for the first time in the present work. The stoichiometric LiNbO3 is non-magnetic, while congruent LiNbO3 and LiTaO3 show very weak ferromagnetism. After chemical reduction in a mixture of zinc and lithium carbonate powders under flowing nitrogen, the ferromagnetic behavior of each sample became clear, with an increased value of magnetization. The saturation magnetization, the magnetic remanence and the coercive field of reduced congruent LiNbO3 are 7.0 × 10‑3 emu g‑1, 0.65 × 10‑3 emu g‑1 and 0.050 kOe, respectively. The ferromagnetism of chemically reduced LiNbO3 and LiTaO3 can be explained by considering the intrinsic Li vacancies, the appearance of Nb4+ (or Ta4+) on the surface with non-zero net spin and the oxygen vacancies at the surface.
Kurakevych, Oleksandr O; Le Godec, Yann; Crichton, Wilson A; Guignard, Jérémy; Strobel, Timothy A; Zhang, Haidong; Liu, Hanyu; Coelho Diogo, Cristina; Polian, Alain; Menguy, Nicolas; Juhl, Stephen J; Gervais, Christel
2016-09-01
Phase-pure samples of a metastable allotrope of silicon, Si-III or BC8, were synthesized by direct elemental transformation at 14 GPa and ∼900 K and also at significantly reduced pressure in the Na-Si system at 9.5 GPa by quenching from high temperatures ∼1000 K. Pure sintered polycrystalline ingots with dimensions ranging from 0.5 to 2 mm can be easily recovered at ambient conditions. The chemical route also allowed us to decrease the synthetic pressures to as low as 7 GPa, while pressures required for direct phase transition in elemental silicon are significantly higher. In situ control of the synthetic protocol, using synchrotron radiation, allowed us to observe the underlying mechanism of chemical interactions and phase transformations in the Na-Si system. Detailed characterization of Si-III using X-ray diffraction, Raman spectroscopy, (29)Si NMR spectroscopy, and transmission electron microscopy are discussed. These large-volume syntheses at significantly reduced pressures extend the range of possible future bulk characterization methods and applications. PMID:27532223
Fernández-Marín, Hermógenes; Zimmerman, Jess K; Nash, David R; Boomsma, Jacobus J; Wcislo, William T
2009-06-22
To combat disease, most fungus-growing ants (Attini) use antibiotics from mutualistic bacteria (Pseudonocardia) that are cultured on the ants' exoskeletons and chemical cocktails from exocrine glands, especially the metapleural glands (MG). Previous work has hypothesized that (i) Pseudonocardia antibiotics are narrow-spectrum and control a fungus (Escovopsis) that parasitizes the ants' fungal symbiont, and (ii) MG secretions have broad-spectrum activity and protect ants and brood. We assessed the relative importance of these lines of defence, and their activity spectra, by scoring abundance of visible Pseudonocardia for nine species from five genera and measuring rates of MG grooming after challenging ants with disease agents of differing virulence. Atta and Sericomyrmex have lost or greatly reduced the abundance of visible bacteria. When challenged with diverse disease agents, including Escovopsis, they significantly increased MG grooming rates and expanded the range of targets. By contrast, species of Acromyrmex and Trachymyrmex maintain abundant Pseudonocardia. When challenged, these species had lower MG grooming rates, targeted primarily to brood. More elaborate MG defences and reduced reliance on mutualistic Pseudonocardia are correlated with larger colony size among attine genera, raising questions about the efficacy of managing disease in large societies with chemical cocktails versus bacterial antimicrobial metabolites.
A reduced chemical kinetic model for IC engine combustion simulations with primary reference fuels
Ra, Youngchul; Reitz, Rolf D.
2008-12-15
A reduced chemical kinetic mechanism for the oxidation of primary reference fuel (PRF) has been developed and applied to model internal combustion engines. Starting from an existing reduced reaction mechanism for n-heptane oxidation, a new reduced n-heptane mechanism was generated by including an additional five species and their relevant reactions, by updating the reaction rate constants of several reactions pertaining to oxidation of carbon monoxide and hydrogen, and by optimizing reaction rate constants of selected reactions. Using a similar approach, a reduced mechanism for iso-octane oxidation was built and combined with the n-heptane mechanism to form a PRF mechanism. The final version of the PRF mechanism consists of 41 species and 130 reactions. Validation of the present PRF mechanism was performed with measurements from shock tube tests, and HCCI and direct injection engine experiments available in the literature. The results show that the present PRF mechanism gives reliable performance for combustion predictions, as well as computational efficiency improvements for multidimensional CFD simulations. (author)
Gordon, Wesley O; Peterson, Gregory W; Durke, Erin M
2015-04-01
Perfluoralkalation via plasma chemical vapor deposition has been used to improve hydrophobicity of surfaces. We have investigated this technique to improve the resistance of commercial polyurethane coatings to chemicals, such as chemical warfare agents. The reported results indicate the surface treatment minimizes the spread of agent droplets and the sorption of agent into the coating. The improvement in resistance is likely due to reduction of the coating's surface free energy via fluorine incorporation, but may also have contributing effects from surface morphology changes. The data indicates that plasma-based surface modifications may have utility in improving chemical resistance of commercial coatings.
Tsvetkov, Nikolai; Lu, Qiyang; Sun, Lixin; Crumlin, Ethan J; Yildiz, Bilge
2016-09-01
Segregation and phase separation of aliovalent dopants on perovskite oxide (ABO3) surfaces are detrimental to the performance of energy conversion systems such as solid oxide fuel/electrolysis cells and catalysts for thermochemical H2O and CO2 splitting. One key reason behind the instability of perovskite oxide surfaces is the electrostatic attraction of the negatively charged A-site dopants (for example, ) by the positively charged oxygen vacancies () enriched at the surface. Here we show that reducing the surface concentration improves the oxygen surface exchange kinetics and stability significantly, albeit contrary to the well-established understanding that surface oxygen vacancies facilitate reactions with O2 molecules. We take La0.8Sr0.2CoO3 (LSC) as a model perovskite oxide, and modify its surface with additive cations that are more and less reducible than Co on the B-site of LSC. By using ambient-pressure X-ray absorption and photoelectron spectroscopy, we proved that the dominant role of the less reducible cations is to suppress the enrichment and phase separation of Sr while reducing the concentration of and making the LSC more oxidized at its surface. Consequently, we found that these less reducible cations significantly improve stability, with up to 30 times faster oxygen exchange kinetics after 54 h in air at 530 °C achieved by Hf addition onto LSC. Finally, the results revealed a 'volcano' relation between the oxygen exchange kinetics and the oxygen vacancy formation enthalpy of the binary oxides of the additive cations. This volcano relation highlights the existence of an optimum surface oxygen vacancy concentration that balances the gain in oxygen exchange kinetics and the chemical stability loss. PMID:27295099
NASA Astrophysics Data System (ADS)
Tsvetkov, Nikolai; Lu, Qiyang; Sun, Lixin; Crumlin, Ethan J.; Yildiz, Bilge
2016-09-01
Segregation and phase separation of aliovalent dopants on perovskite oxide (ABO3) surfaces are detrimental to the performance of energy conversion systems such as solid oxide fuel/electrolysis cells and catalysts for thermochemical H2O and CO2 splitting. One key reason behind the instability of perovskite oxide surfaces is the electrostatic attraction of the negatively charged A-site dopants (for example, ) by the positively charged oxygen vacancies () enriched at the surface. Here we show that reducing the surface concentration improves the oxygen surface exchange kinetics and stability significantly, albeit contrary to the well-established understanding that surface oxygen vacancies facilitate reactions with O2 molecules. We take La0.8Sr0.2CoO3 (LSC) as a model perovskite oxide, and modify its surface with additive cations that are more and less reducible than Co on the B-site of LSC. By using ambient-pressure X-ray absorption and photoelectron spectroscopy, we proved that the dominant role of the less reducible cations is to suppress the enrichment and phase separation of Sr while reducing the concentration of and making the LSC more oxidized at its surface. Consequently, we found that these less reducible cations significantly improve stability, with up to 30 times faster oxygen exchange kinetics after 54 h in air at 530 °C achieved by Hf addition onto LSC. Finally, the results revealed a `volcano' relation between the oxygen exchange kinetics and the oxygen vacancy formation enthalpy of the binary oxides of the additive cations. This volcano relation highlights the existence of an optimum surface oxygen vacancy concentration that balances the gain in oxygen exchange kinetics and the chemical stability loss.
NASA Astrophysics Data System (ADS)
Perera, Sanjaya D.; Mariano, Ruperto G.; Nijem, Nour; Chabal, Yves; Ferraris, John P.; Balkus, Kenneth J.
2012-10-01
Graphene is a promising electrode material for energy storage applications. The most successful method for preparing graphene from graphite involves the oxidation of graphite to graphene oxide (GO) and reduction back to graphene. Even though different chemical and thermal methods have been developed to reduce GO to graphene, the use of less toxic materials to generate graphene still remains a challenge. In this study we developed a facile one-pot synthesis of deoxygenated graphene (hGO) via alkaline hydrothermal process, which exhibits similar properties to the graphene obtained via hydrazine reduction (i.e. the same degree of deoxygenation found in hydrazine reduced GO). Moreover, the hGO formed freestanding, binder-free paper electrodes for supercapacitors. Coin cell type (CR2032) symmetric supercapacitors were assembled using the hGO electrodes. Electrochemical characterization of hGO was carried out using lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) and ethylmethylimidazolium bis-(trifluoromethanesulfonyl)imide (EMITFSI) electrolytes. The results for the hGO electrodes were compared with the hydrazine reduced GO (rGO) electrode. The hGO electrode exhibits a energy density of 20 W h kg-1 and 50 W h kg-1 in LiTFSI and EMITFSI respectively, while delivering a maximum power density of 11 kW kg-1 and 14.7 kW kg-1 in LiTFSI and EMITFSI, respectively.
Screening of mRNA Chemical Modification to Maximize Protein Expression with Reduced Immunogenicity
Uchida, Satoshi; Kataoka, Kazunori; Itaka, Keiji
2015-01-01
Chemical modification of nucleosides in mRNA is an important technology to regulate the immunogenicity of mRNA. In this study, various previously reported mRNA formulations were evaluated by analyzing in vitro protein expression and immunogenicity in multiple cell lines. For the macrophage-derived cell line, RAW 264.7, modified mRNA tended to have reduced immunogenicity and increased protein expression compared to the unmodified mRNA. In contrast, in some cell types, such as hepatocellular carcinoma cells (HuH-7) and mouse embryonic fibroblasts (MEFs), protein expression was decreased by mRNA modification. Further analyses revealed that mRNA modifications decreased translation efficiency but increased nuclease stability. Thus, mRNA modification is likely to exert both positive and negative effects on the efficiency of protein expression in transfected cells and optimal mRNA formulation should be determined based on target cell types and transfection purposes. PMID:26213960
Ultrafast and sensitive room temperature NH3 gas sensors based on chemically reduced graphene oxide
NASA Astrophysics Data System (ADS)
Hu, Nantao; Yang, Zhi; Wang, Yanyan; Zhang, Liling; Wang, Ying; Huang, Xiaolu; Wei, Hao; Wei, Liangmin; Zhang, Yafei
2014-01-01
Ultrafast and sensitive room temperature NH3 gas sensors based on chemically reduced graphene oxide (rGO) are demonstrated in this work. rGO, which was prepared via the reduction of graphene oxide by pyrrole, exhibited excellent responsive sensitivity and selectivity to ammonia (NH3) gas. The high sensing performance of these rGO sensors with resistance change as high as 2.4% and response time as fast as 1.4 s was realized when the concentration of NH3 gas was as low as 1 ppb. Furthermore, the rGO sensors could rapidly recover to their initial states with IR illumination. The devices also showed excellent repeatability and selectivity to NH3. These rGO sensors, with low cost, low power, and easy fabrication, as well as scalable properties, showed great potential for ultrasensitive detection of NH3 gas in a wide variety of fields.
Ferromagnetic inks facilitate large scale paper recycling and reduce bleach chemical consumption.
Zeltner, Martin; Toedtli, Laura M; Hild, Nora; Fuhrer, Roland; Rossier, Michaël; Gerber, Lukas C; Raso, Renzo A; Grass, Robert N; Stark, Wendelin J
2013-04-23
Deinking is a fundamental part of paper recycling. As the global paper consumption rises and exceeds even the annual paper production, recycling of this raw material is of high importance. Magnetic ink based on carbon coated magnetic nanoparticles enables an alternative approach to state of the art paper deinking. Magnetic deinking comprises three steps (preselection, washing, and magnetic separation of fibers). Preseparation of printed from nonprinted scraps of paper is feasible and reduces the paper mass which has to be fed into a deinking process. A consecutive washing process removes surficial magnetic ink that can be collected by application of a permanent magnet. Still, printed parts are subjected to a further continuous magnetic deinking step, where magnetic and nonmagnetic paper fibers can be separated. Magnetic deinking of a model print allows recovery of more than 80% of bright fibers without any harsh chemical treatment and the re-collection of more than 82% of magnetic ink. PMID:23495668
Ferromagnetic inks facilitate large scale paper recycling and reduce bleach chemical consumption.
Zeltner, Martin; Toedtli, Laura M; Hild, Nora; Fuhrer, Roland; Rossier, Michaël; Gerber, Lukas C; Raso, Renzo A; Grass, Robert N; Stark, Wendelin J
2013-04-23
Deinking is a fundamental part of paper recycling. As the global paper consumption rises and exceeds even the annual paper production, recycling of this raw material is of high importance. Magnetic ink based on carbon coated magnetic nanoparticles enables an alternative approach to state of the art paper deinking. Magnetic deinking comprises three steps (preselection, washing, and magnetic separation of fibers). Preseparation of printed from nonprinted scraps of paper is feasible and reduces the paper mass which has to be fed into a deinking process. A consecutive washing process removes surficial magnetic ink that can be collected by application of a permanent magnet. Still, printed parts are subjected to a further continuous magnetic deinking step, where magnetic and nonmagnetic paper fibers can be separated. Magnetic deinking of a model print allows recovery of more than 80% of bright fibers without any harsh chemical treatment and the re-collection of more than 82% of magnetic ink.
Screening of mRNA Chemical Modification to Maximize Protein Expression with Reduced Immunogenicity.
Uchida, Satoshi; Kataoka, Kazunori; Itaka, Keiji
2015-01-01
Chemical modification of nucleosides in mRNA is an important technology to regulate the immunogenicity of mRNA. In this study, various previously reported mRNA formulations were evaluated by analyzing in vitro protein expression and immunogenicity in multiple cell lines. For the macrophage-derived cell line, RAW 264.7, modified mRNA tended to have reduced immunogenicity and increased protein expression compared to the unmodified mRNA. In contrast, in some cell types, such as hepatocellular carcinoma cells (HuH-7) and mouse embryonic fibroblasts (MEFs), protein expression was decreased by mRNA modification. Further analyses revealed that mRNA modifications decreased translation efficiency but increased nuclease stability. Thus, mRNA modification is likely to exert both positive and negative effects on the efficiency of protein expression in transfected cells and optimal mRNA formulation should be determined based on target cell types and transfection purposes. PMID:26213960
Chang, Sung-Jin; Hyun, Moon Seop; Myung, Sung; Kang, Min-A; Yoo, Jung Ho; Lee, Kyoung G.; Choi, Bong Gill; Cho, Youngji; Lee, Gaehang; Park, Tae Jung
2016-01-01
Understanding the underlying mechanisms involved in graphene growth via chemical vapour deposition (CVD) is critical for precise control of the characteristics of graphene. Despite much effort, the actual processes behind graphene synthesis still remain to be elucidated in a large number of aspects. Herein, we report the evolution of graphene properties during in-plane growth of graphene from reduced graphene oxide (RGO) on copper (Cu) via methane CVD. While graphene is laterally grown from RGO flakes on Cu foils up to a few hundred nanometres during CVD process, it shows appreciable improvement in structural quality. The monotonous enhancement of the structural quality of the graphene with increasing length of the graphene growth from RGO suggests that seeded CVD growth of graphene from RGO on Cu surface is accompanied by the restoration of graphitic structure. The finding provides insight into graphene growth and defect reconstruction useful for the production of tailored carbon nanostructures with required properties. PMID:26961409
Federal Register 2010, 2011, 2012, 2013, 2014
2011-11-17
... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF AGRICULTURE National Agricultural Statistics Service Notice of Intent To Reduce the Frequency of Chemical Use Surveys and All Associated Reports AGENCY: National Agricultural Statistics Service, USDA. ACTION: Notice...
Gowler, Camden D; Leon, Kristoffer E; Hunter, Mark D; de Roode, Jacobus C
2015-06-01
In tri-trophic systems, herbivores may benefit from their host plants in fighting parasitic infections. Plants can provide parasite resistance in two contrasting ways: either directly, by interfering with the parasite, or indirectly, by increasing herbivore immunity or health. In monarch butterflies, the larval diet of milkweed strongly influences the fitness of a common protozoan parasite. Toxic secondary plant chemicals known as cardenolides correlate strongly with parasite resistance of the host, with greater cardenolide concentrations in the larval diet leading to lower parasite growth. However, milkweed cardenolides may covary with other indices of plant quality including nutrients, and a direct experimental link between cardenolides and parasite performance has not been established. To determine if the anti-parasitic activity of milkweeds is indeed due to secondary chemicals, as opposed to nutrition, we supplemented the diet of infected and uninfected monarch larvae with milkweed latex, which contains cardenolides but no nutrients. Across three experiments, increased dietary cardenolide concentrations reduced parasite growth in infected monarchs, which consequently had longer lifespans. However, uninfected monarchs showed no differences in lifespan across treatments, confirming that cardenolide-containing latex does not increase general health. Our results suggest that cardenolides are a driving force behind plant-derived resistance in this system. PMID:25953502
Liu, Shizhen; Peng, Wenchao; Sun, Hongqi; Wang, Shaobin
2014-01-21
Physical and chemical activation of reduced graphene oxide (RGO) using different reagents, CO2, ZnCl2 and CO2/ZnCl2, to obtain highly porous and metal-free carbonaceous materials was carried out and their adsorption and catalytic behavior were investigated. Physical activation using CO2 was proved to be much more effective than chemical ZnCl2 activation, and increased the specific surface area (SSA) of RGO from ~200 to higher than 600 m(2) g(-1). Methylene blue (MB) was then used to evaluate the adsorption and catalytic activity of the activated RGO (A-RGO) materials with peroxymonosulfate (PMS) as an oxidant. It was found that the SSA and oxygen containing groups are two important factors determining the adsorptive and catalytic performance of the A-RGO materials. RGO by physicochemical CO2/ZnCl2 activation presented the best adsorption and RGO by physical CO2 activation exhibited the highest catalytic degradation of MB.
Lötsch, J; Hummel, T; Warskulat, U; Coste, O; Häussinger, D; Geisslinger, G; Tegeder, I
2014-02-14
The amino acid taurine is required for development and functioning of the central and peripheral nervous system where it exerts osmoregulatory, neuromodulatory and anti-apoptotic actions. It is subject to cellular import by the taurine transporter slc6a6. Absence of the transporter and consequently, absence of taurine leads to several neurologic deficits and sensory losses. In a slc6a6 knock-out mouse model, consequences of congenital taurine deficiency were assessed in nociceptive sensory processes. The formalin assay, hot plate assay, and summated generator potentials in response to local nociceptive stimulation with gaseous CO2 were applied. Reduced responsiveness of slc6a6(-/-) mice to nociceptive stimulation was observed in particular to chemical nociceptive stimuli. Scl6a6 knock-out mice spent significantly less time licking the formalin injected paw and displayed smaller amplitudes of the nociceptive nasal mucosa potentials than wild-type mice (p=0.002 and 0.01 respectively). In contrast, withdrawal latencies on a hot plate did not significantly differ, suggesting that intracellular taurine deficits lead in particular to a hyposensitivity of nociceptive sensory neurons sensitive to noxious chemical stimulation. As hereditary absence of taurine affects biological processes of anatomical structure development, the altered nociceptive responses likely reflect consequences of compromised peripheral nervous system development.
NASA Astrophysics Data System (ADS)
Benchirouf, Abderrahmane; Müller, Christian; Kanoun, Olfa
2016-01-01
In this paper, we propose strain-sensitive thin films based on chemically reduced graphene oxide (GO) and multi-walled carbon nanotubes (MWCNTs) without adding any further surfactants. In spite of the insulating properties of the thin-film-based GO due to the presence functional groups such as hydroxyl, epoxy, and carbonyl groups in its atomic structure, a significant enhancement of the film conductivity was reached by chemical reduction with hydro-iodic acid. By optimizing the MWCNT content, a significant improvement of electrical and mechanical thin film sensitivity is realized. The optical properties and the morphology of the prepared thin films were studied using ultraviolet-visible spectroscopy (UV-Vis) and scanning electron microscope (SEM). The UV-Vis spectra showed the ability to tune the band gap of the GO by changing the MWCNT content, whereas the SEM indicated that the MWCNTs were well dissolved and coated by the GO. Investigations of the piezoresistive properties of the hybrid nanocomposite material under mechanical load show a linear trend between the electrical resistance and the applied strain. A relatively high gauge factor of 8.5 is reached compared to the commercial metallic strain gauges. The self-assembled hybrid films exhibit outstanding properties in electric conductivity, mechanical strength, and strain sensitivity, which provide a high potential for use in strain-sensing applications.
Gowler, Camden D; Leon, Kristoffer E; Hunter, Mark D; de Roode, Jacobus C
2015-06-01
In tri-trophic systems, herbivores may benefit from their host plants in fighting parasitic infections. Plants can provide parasite resistance in two contrasting ways: either directly, by interfering with the parasite, or indirectly, by increasing herbivore immunity or health. In monarch butterflies, the larval diet of milkweed strongly influences the fitness of a common protozoan parasite. Toxic secondary plant chemicals known as cardenolides correlate strongly with parasite resistance of the host, with greater cardenolide concentrations in the larval diet leading to lower parasite growth. However, milkweed cardenolides may covary with other indices of plant quality including nutrients, and a direct experimental link between cardenolides and parasite performance has not been established. To determine if the anti-parasitic activity of milkweeds is indeed due to secondary chemicals, as opposed to nutrition, we supplemented the diet of infected and uninfected monarch larvae with milkweed latex, which contains cardenolides but no nutrients. Across three experiments, increased dietary cardenolide concentrations reduced parasite growth in infected monarchs, which consequently had longer lifespans. However, uninfected monarchs showed no differences in lifespan across treatments, confirming that cardenolide-containing latex does not increase general health. Our results suggest that cardenolides are a driving force behind plant-derived resistance in this system.
Tao, Leiling; Hoang, Kevin M; Hunter, Mark D; de Roode, Jacobus C
2016-09-01
The emerging field of ecological immunology demonstrates that allocation by hosts to immune defence against parasites is constrained by the costs of those defences. However, the costs of non-immunological defences, which are important alternatives to canonical immune systems, are less well characterized. Estimating such costs is essential for our understanding of the ecology and evolution of alternative host defence strategies. Many animals have evolved medication behaviours, whereby they use antiparasitic compounds from their environment to protect themselves or their kin from parasitism. Documenting the costs of medication behaviours is complicated by natural variation in the medicinal components of diets and their covariance with other dietary components, such as macronutrients. In the current study, we explore the costs of the usage of antiparasitic compounds in monarch butterflies (Danaus plexippus), using natural variation in concentrations of antiparasitic compounds among plants. Upon infection by their specialist protozoan parasite Ophryocystis elektroscirrha, monarch butterflies can selectively oviposit on milkweed with high foliar concentrations of cardenolides, secondary chemicals that reduce parasite growth. Here, we show that these antiparasitic cardenolides can also impose significant costs on both uninfected and infected butterflies. Among eight milkweed species that vary substantially in their foliar cardenolide concentration and composition, we observed the opposing effects of cardenolides on monarch fitness traits. While high foliar cardenolide concentrations increased the tolerance of monarch butterflies to infection, they reduced the survival rate of caterpillars to adulthood. Additionally, although non-polar cardenolide compounds decreased the spore load of infected butterflies, they also reduced the life span of uninfected butterflies, resulting in a hump-shaped curve between cardenolide non-polarity and the life span of infected butterflies
Barzel, Baruch; Biham, Ofer; Kupferman, Raz; Lipshtat, Azi; Zait, Amir
2010-08-01
Chemical reaction networks which exhibit strong fluctuations are common in microscopic systems in which reactants appear in low copy numbers. The analysis of these networks requires stochastic methods, which come in two forms: direct integration of the master equation and Monte Carlo simulations. The master equation becomes infeasible for large networks because the number of equations increases exponentially with the number of reactive species. Monte Carlo methods, which are more efficient in integrating over the exponentially large phase space, also become impractical due to the large amounts of noisy data that need to be stored and analyzed. The recently introduced multiplane method [A. Lipshtat and O. Biham, Phys. Rev. Lett. 93, 170601 (2004)] is an efficient framework for the stochastic analysis of large reaction networks. It is a dimensional reduction method, based on the master equation, which provides a dramatic reduction in the number of equations without compromising the accuracy of the results. The reduction is achieved by breaking the network into a set of maximal fully connected subnetworks (maximal cliques). A separate master equation is written for the reduced probability distribution associated with each clique, with suitable coupling terms between them. This method is highly efficient in the case of sparse networks, in which the maximal cliques tend to be small. However, in dense networks some of the cliques may be rather large and the dimensional reduction is not as effective. Furthermore, the derivation of the multiplane equations from the master equation is tedious and difficult. Here we present the reduced-multiplane method in which the maximal cliques are broken down to the fundamental two-vertex cliques. The number of equations is further reduced, making the method highly efficient even for dense networks. Moreover, the equations take a simpler form, which can be easily constructed using a diagrammatic procedure, for any desired network
Chemical defense in Elodea nuttallii reduces feeding and growth of aquatic herbivorous Lepidoptera.
Erhard, Daniela; Pohnert, Georg; Gross, Elisabeth M
2007-08-01
The submersed macrophyte Elodea nuttallii (Hydrocharitaceae) is invasive in Europe and frequently found in aquatic plant communities. Many invertebrate herbivores, such as larvae of the generalist aquatic moth, Acentria ephemerella (Lepidoptera, Pyralidae), avoid feeding on E. nuttallii and preferably consume native species. First instar larvae exhibited a high mortality on E. nuttallii compared to the native macrophyte Potamogeton perfoliatus. Mortality of older larvae was also high when fed E. nuttallii exposed to high light intensities. Growth of older larvae was strongly reduced on E. nuttallii compared to pondweeds (Potamogeton lucens). Neither differences in nitrogen nor phosphorus content explained the different performance on these submerged macrophytes, but plants differed in their flavonoid content. To investigate whether plant-derived allelochemicals from E. nuttallii affect larval performance in the same way as live plants, we developed a functional bioassay, in which Acentria larvae were reared on artificial diets. We offered larvae Potamogeton leaf disks coated with crude Elodea extracts and partially purified flavonoids. Elodea extracts deterred larvae from feeding on otherwise preferred Potamogeton leaves, and yet, unknown compounds in the extracts reduced growth and survival of Acentria. The flavonoid fraction containing luteolin-7-O-diglucuronide, apigenin-7-O-diglucuronide, and chrysoeriol-7-O-diglucuronide strongly reduced feeding of larvae, but did not increase mortality. The concentrations of these compounds in our assays were 0.01-0.09% of plant dry mass, which is in the lower range of concentrations found in the field (0.02-1.2%). Chemical defense in E. nuttallii thus plays an ecologically relevant role in this aquatic plant-herbivore system. PMID:17577598
Gadolinium chloride reduces cytochrome P450: relevance to chemical-induced hepatotoxicity.
Badger, D A; Kuester, R K; Sauer, J M; Sipes, I G
1997-08-15
The Kupffer cell inhibitor, gadolinium chloride (GdCl3), protects the liver from a number of toxicants that require biotransformation to elicit toxicity (i.e. 1,2-dichlorobenzene and CCl4), as well as compounds that do not (i.e. cadmium chloride and beryllium sulfate). The mechanism of this protection is thought to result from reduced secretion of inflammatory and cytotoxic products from Kupffer cells (KC). However, since other lanthanides have been shown to decrease cytochrome P450 (P450) activity, the following studies were designed to determine if GdCl3 pretreatment alters hepatic P450 levels or activity. The toxicological relevance of GdCl3-mediated alterations in P450 activity was also estimated by determining the effect of GdCl3 pretreatment on the susceptibility of primary cultured hepatocytes to CCl4 and cadmium chloride (CdCl2). Male and female Sprague-Dawley rats were given GdCl3 (i.v., 10 mg/kg). Twenty-four hours later, livers were either processed for preparation of microsomes or for primary cultures of hepatocytes. Gadolinium chloride treatment reduced total hepatic microsomal P450 as well as aniline hydroxylase activity by approximately 30% in males and 20% in females. In hepatocytes isolated from rats pretreated with GdCl3, the toxicity caused by CCl4, but not CdCl2 was reduced. Interestingly, when GdCl3 was administered in vitro to microsomes, there was no effect on either the microsomal P450 difference spectra or p-hydroxylation of aniline. However, when GdCl3 was incubated with isolated hepatocytes, the cytotoxicity of CCl4 (but not CdCl2) was partially attenuated. These results suggest that, in addition to its inhibitory effects on KC, GdCl3 produces other effects which may alter the susceptibility of hepatocytes to toxicity caused by certain chemicals.
Tao, Leiling; Hoang, Kevin M; Hunter, Mark D; de Roode, Jacobus C
2016-09-01
The emerging field of ecological immunology demonstrates that allocation by hosts to immune defence against parasites is constrained by the costs of those defences. However, the costs of non-immunological defences, which are important alternatives to canonical immune systems, are less well characterized. Estimating such costs is essential for our understanding of the ecology and evolution of alternative host defence strategies. Many animals have evolved medication behaviours, whereby they use antiparasitic compounds from their environment to protect themselves or their kin from parasitism. Documenting the costs of medication behaviours is complicated by natural variation in the medicinal components of diets and their covariance with other dietary components, such as macronutrients. In the current study, we explore the costs of the usage of antiparasitic compounds in monarch butterflies (Danaus plexippus), using natural variation in concentrations of antiparasitic compounds among plants. Upon infection by their specialist protozoan parasite Ophryocystis elektroscirrha, monarch butterflies can selectively oviposit on milkweed with high foliar concentrations of cardenolides, secondary chemicals that reduce parasite growth. Here, we show that these antiparasitic cardenolides can also impose significant costs on both uninfected and infected butterflies. Among eight milkweed species that vary substantially in their foliar cardenolide concentration and composition, we observed the opposing effects of cardenolides on monarch fitness traits. While high foliar cardenolide concentrations increased the tolerance of monarch butterflies to infection, they reduced the survival rate of caterpillars to adulthood. Additionally, although non-polar cardenolide compounds decreased the spore load of infected butterflies, they also reduced the life span of uninfected butterflies, resulting in a hump-shaped curve between cardenolide non-polarity and the life span of infected butterflies
Soares, Cristina Neves Girao Salgado; Amaral, Flavia Lucisano Botelho do; Mesquita, Marcelo Ferraz; Franca, Fabiana Mantovani Gomes; Basting, Roberta Tarkany; Turssi, Cecilia Pedroso
2015-01-01
This in vitro study evaluated the efficacy of toothpastes containing abrasive and chemical whitening agents in reducing the extrinsic discoloration of dental enamel. Sixty slabs of dentin from human teeth were sealed so that only the enamel surface was exposed. The enamel surfaces were photographed for initial color assessment. Staining was performed by immersing the dental slabs in 0.2% chlorhexidine solution for 2 minutes and then in black tea for 60 minutes. This process was repeated 15 times. Photographs were taken at the end of the staining process, and the slabs were divided into 5 groups (n = 12), 3 to be brushed with toothpastes containing chemical whitening agents (2 containing phosphate salts and 1 containing phosphate salts plus hydrogen peroxide) and 2 to represent control groups (ordinary/nonwhitening toothpaste and distilled water). The dental slabs were subjected to mechanical toothbrushing with toothpaste slurry or distilled water, according to each group's specifications. After brushing, more photographs were taken for color analysis. The results showed a significant reduction in luminosity after the staining process in addition to an increase in the colors red and yellow (P < 0.001). After brushing, there was a significant increase in luminosity and a reduction in both red and yellow (P < 0.001). However, there was no observed difference between the changes in color values in dental enamel slabs brushed with whitening toothpastes and the changes found in slabs brushed with ordinary toothpaste. The whitening toothpastes did not outperform an ordinary toothpaste in the removal of extrinsic staining. PMID:26545284
Reducing drinking water supply chemical contamination: risks from underground storage tanks.
Enander, Richard T; Hanumara, R Choudary; Kobayashi, Hisanori; Gagnon, Ronald N; Park, Eugene; Vallot, Christopher; Genovesi, Richard
2012-12-01
Drinking water supplies are at risk of contamination from a variety of physical, chemical, and biological sources. Ranked among these threats are hazardous material releases from leaking or improperly managed underground storage tanks located at municipal, commercial, and industrial facilities. To reduce human health and environmental risks associated with the subsurface storage of hazardous materials, government agencies have taken a variety of legislative and regulatory actions--which date back more than 25 years and include the establishment of rigorous equipment/technology/operational requirements and facility-by-facility inspection and enforcement programs. Given a history of more than 470,000 underground storage tank releases nationwide, the U.S. Environmental Protection Agency continues to report that 7,300 new leaks were found in federal fiscal year 2008, while nearly 103,000 old leaks remain to be cleaned up. In this article, we report on an alternate evidence-based intervention approach for reducing potential releases from the storage of petroleum products (gasoline, diesel, kerosene, heating/fuel oil, and waste oil) in underground tanks at commercial facilities located in Rhode Island. The objective of this study was to evaluate whether a new regulatory model can be used as a cost-effective alternative to traditional facility-by-facility inspection and enforcement programs for underground storage tanks. We conclude that the alternative model, using an emphasis on technical assistance tools, can produce measurable improvements in compliance performance, is a cost-effective adjunct to traditional facility-by-facility inspection and enforcement programs, and has the potential to allow regulatory agencies to decrease their frequency of inspections among low risk facilities without sacrificing compliance performance or increasing public health risks.
A Probablistic Diagram to Guide Chemical Design with Reduced Potency to Incur Cytotoxicity
Toxicity is a concern with many chemicals currently in commerce, and with new chemicals that are introduced each year. The standard approach to testing chemicals is to run studies in laboratory animals (e.g. rats, mice, dogs), but because of the expense of these studies and conce...
Reducing the emission of ozone depleting chemicals through use of a self-cleaning soldering process
Lichtenberg, L.; Martin, G.; Van Buren, P.; Iman, R.; Paffett, M.T.
1991-12-31
Motorola has jointed with Sandia and Los Alamos National Laboratories to perform work under a Cooperative Research and Development Agreement (CRADA) to reduce the use of CFC`s and other ozone depleting printing wiring board (PWB) cleaning solvents. This study evaluated the use of a new soldering process that uses dilute adipic acid in lieu of rosin flux. The process consumes the adipic acid in lieu of rosin flux. The process consumes the adipic acid during the soldering process and precludes the need for subsequent cleaning with ozone depleting solvents. This paper presents results from a series of designed experiments that evaluated PWB cleanliness as a function of various levels of machine control parameters. The study included a comprehensive hardware reliability evaluation, which included environmental conditioning, cleanliness testing, surface chemical analysis, surface insulation resistance testing, along with electrical, mechanical and long term storage testing. The results of this study that the new process produces quality, reliable hardware over a wide range of processing parameters. Adoption of this process, which eliminates the need for supplemental cleaning, will have a positive impact on many environmental problems, including depletion of the ozone layer.
Reducing the emission of ozone depleting chemicals through use of a self-cleaning soldering process
Lichtenberg, L.; Martin, G.; Van Buren, P. . Government Electronics Group); Iman, R. ); Paffett, M.T. )
1991-01-01
Motorola has jointed with Sandia and Los Alamos National Laboratories to perform work under a Cooperative Research and Development Agreement (CRADA) to reduce the use of CFC's and other ozone depleting printing wiring board (PWB) cleaning solvents. This study evaluated the use of a new soldering process that uses dilute adipic acid in lieu of rosin flux. The process consumes the adipic acid in lieu of rosin flux. The process consumes the adipic acid during the soldering process and precludes the need for subsequent cleaning with ozone depleting solvents. This paper presents results from a series of designed experiments that evaluated PWB cleanliness as a function of various levels of machine control parameters. The study included a comprehensive hardware reliability evaluation, which included environmental conditioning, cleanliness testing, surface chemical analysis, surface insulation resistance testing, along with electrical, mechanical and long term storage testing. The results of this study that the new process produces quality, reliable hardware over a wide range of processing parameters. Adoption of this process, which eliminates the need for supplemental cleaning, will have a positive impact on many environmental problems, including depletion of the ozone layer.
NASA Astrophysics Data System (ADS)
Saini, Parveen; Kaushik, Sachin; Sharma, Rahul; Chakravarty, Disha; Raj, Rishi; Sharma, Jyotirmay
2016-06-01
Graphitic oxide (GO) was synthesized by oxidation of graphite powder using Hummer's method and the formed GO is solution processed into paper-like macroscopic form. Subsequently, chemically reduced graphitic oxide paper (CRGOP) is prepared by hydrazine vapours induced reduction of formed GO precursor based paper. The formation of GO and its successful reduction to RGO phase is confirmed by FTIR, Raman Spectroscopy and X-ray diffraction. It has been observed that due to high electrical conductivity ~200 micron thick CRGOP display excellent EMI shielding performance at very high frequency of 101 GHz frequency with total shielding effectiveness (SE) value of -35.49 dB (i.e. >99.97% blocking of incident EM radiation) which is much higher compared to pristine GO paper (-1.55 dB) or comparable to expanded graphite (EG) sheet (-35.61 dB). Due to their lightweight nature, these freestanding CRGOPs display average specific SE value of -221.8 dB cm3/g. Besides, their excellent flexibility and makes them potential candidate for lightweight EMI gasketing material compared to other forms of flexible carbons like EG.
Elburki, Muna S.; Rossa, Carlos; Guimaraes, Morgana R.; Goodenough, Mark; Lee, Hsi-Ming; Curylofo, Fabiana A.; Zhang, Yu; Johnson, Francis; Golub, Lorne M.
2014-01-01
Tetracycline-based matrix metalloproteinase- (MMP-) inhibitors are currently approved for two inflammatory diseases, periodontitis and rosacea. The current study addresses the therapeutic potential of a novel pleiotropic MMP-inhibitor not based on an antibiotic. To induce experimental periodontitis, endotoxin (LPS) was repeatedly injected into the gingiva of rats on one side of the maxilla; the contralateral (control) side received saline injections. Two groups of rats were treated by daily oral intubation with a chemically modified curcumin, CMC 2.24, for two weeks; the control groups received vehicle alone. After sacrifice, gingiva, blood, and maxilla were collected, the jaws were defleshed, and periodontal (alveolar) bone loss was quantified morphometrically and by μ-CT scan. The gingivae were pooled per experimental group, extracted, and analyzed for MMPs (gelatin zymography; western blot) and for cytokines (e.g., IL-1β; ELISA); serum and plasma samples were analyzed for cytokines and MMP-8. The LPS-induced pathologically excessive bone loss was reduced to normal levels based on either morphometric (P = 0.003) or μ-CT (P = 0.008) analysis. A similar response was seen for MMPs and cytokines in the gingiva and blood. This initial study, on a novel triketonic zinc-binding CMC, indicates potential efficacy on inflammatory mediators and alveolar bone loss in experimental periodontitis and warrants future therapeutic and pharmacokinetic investigations. PMID:25104884
Potumarthi, Ravichandra; Baadhe, Rama Raju; Pisipati, Aparna; Jetty, Annapurna
2014-11-01
Two commonly used chemical pretreatment processes, sulphuric acid, and sodium hydroxide, were tested to provide comparative performance data. A connection between solid to liquid ratio (S/L) and sugars released was observed with an increase in S/L ratio between 0.02 and 0.2. Enzymatic digestibility of 1 M of NaOH-pretreated corncobs were released 210.7 mg ml(-1) of sugars. Further, compared with different concentrations of acid pretreatments at 0.05, 0.1, 0.15, 0.2, 0.25, 0.3, and 0.5 M concentrations, sodium hydroxide pretreatment of corncob substantially increased accessibility and digestibility of cellulose. Another additional observation made was whole-cell and crude enzymatic hydrolysis of different concentrations of acid and NaOH (0.05, 0.1, 0.25 M)-treated materials released lower amount of sugars compared with the sugars released (310.9 mg ml(-1)) with whole-cell hydrolysis of 1 M of NaOH-treated corncobs. NaOH-pretreated corncobs contained higher content of sugars and which is more suitable for production of reducing sugars.
Stoliker, Deborah L.; Campbell, Kate M.; Fox, Patricia M.; Singer, David M.; Kaviani, Nazila; Carey, Minna; Peck, Nicole E.; Barger, John R.; Kent, Douglas B.; Davis, James A.
2013-01-01
Extraction techniques utilizing high pH and (bi)carbonate concentrations were evaluated for their efficacy in determining the oxidation state of uranium (U) in reduced sediments collected from Rifle, CO. Differences in dissolved concentrations between oxic and anoxic extractions have been proposed as a means to quantify the U(VI) and U(IV) content of sediments. An additional step was added to anoxic extractions using a strong anion exchange resin to separate dissolved U(IV) and U(VI). X-ray spectroscopy showed that U(IV) in the sediments was present as polymerized precipitates similar to uraninite and/or less ordered U(IV), referred to as non-uraninite U(IV) species associated with biomass (NUSAB). Extractions of sediment containing both uraninite and NUSAB displayed higher dissolved uranium concentrations under oxic than anoxic conditions while extractions of sediment dominated by NUSAB resulted in identical dissolved U concentrations. Dissolved U(IV) was rapidly oxidized under anoxic conditions in all experiments. Uraninite reacted minimally under anoxic conditions but thermodynamic calculations show that its propensity to oxidize is sensitive to solution chemistry and sediment mineralogy. A universal method for quantification of U(IV) and U(VI) in sediments has not yet been developed but the chemical extractions, when combined with solid-phase characterization, have a narrow range of applicability for sediments without U(VI).
Chemical Reactivity Probes for Assessing Abiotic Natural Attenuation by Reducing Iron Minerals.
Fan, Dimin; Bradley, Miranda J; Hinkle, Adrian W; Johnson, Richard L; Tratnyek, Paul G
2016-02-16
Increasing recognition that abiotic natural attenuation (NA) of chlorinated solvents can be important has created demand for improved methods to characterize the redox properties of the aquifer materials that are responsible for abiotic NA. This study explores one promising approach: using chemical reactivity probes (CRPs) to characterize the thermodynamic and kinetic aspects of contaminant reduction by reducing iron minerals. Assays of thermodynamic CRPs were developed to determine the reduction potentials (ECRP) of suspended minerals by spectrophotometric determination of equilibrium CRP speciation and calculations using the Nernst equation. ECRP varied as expected with mineral type, mineral loading, and Fe(II) concentration. Comparison of ECRP with reduction potentials measured potentiometrically using a Pt electrode (EPt) showed that ECRP was 100-150 mV more negative than EPt. When EPt was measured with small additions of CRPs, the systematic difference between EPt and ECRP was eliminated, suggesting that these CRPs are effective mediators of electron transfer between mineral and electrode surfaces. Model contaminants (4-chloronitrobenzene, 2-chloroacetophenone, and carbon tetrachloride) were used as kinetic CRPs. The reduction rate constants of kinetic CRPs correlated well with the ECRP for mineral suspensions. Using the rate constants compiled from literature for contaminants and relative mineral reduction potentials based on ECRP measurements, qualitatively consistent trends were obtained, suggesting that CRP-based assays may be useful for estimating abiotic NA rates of contaminants in groundwater.
Zhu, Jiangfeng; Sanchez, Ailen; Bennett, George N.; San, Ka-Yiu
2011-01-01
Optimizing the productivity of bioengineered strains requires balancing ATP generation and carbon atom conservation through fine-tuning cell respiration and metabolism. Traditional approaches manipulate cell respiration by altering air feeding, which are technically difficult especially in large bioreactors. An approach based on genetic regulation may better serve this purpose. With excess oxygen supply to the culture, we efficiently manipulated Escherichia coli cell respiration by adding different amount of coenzyme Q1 to strains lacking the ubiCA genes, which encode two critical enzymes for ubiquinone synthesis. As a proof-of-concept, the metabolic effect of the ubiCA gene knockout and coenzyme Q1 supplementation were characterized, and the metabolic profiles of the experimental strains showed clear correlations with coenzyme Q1 concentrations. Further proof-of-principle experiments were performed to illustrate that the approach can be used to optimize cell respiration for the production of chemicals of interest such as ethanol. This study showed that controlled respiration through genetic manipulation can be exploited to allow much larger operating windows for reduced product formation even under fully aerobic conditions. PMID:22001430
Graphenol defects induced blue emission enhancement in chemically reduced graphene quantum dots.
Zhang, Wenkai; Liu, Yingqiu; Meng, Xianrui; Ding, Tao; Xu, Yuanqing; Xu, Hao; Ren, Yanrong; Liu, Baoying; Huang, Jiajia; Yang, Jinghe; Fang, Xiaomin
2015-09-14
In this work, few layer graphene quantum dots (GQDs) with a size of 3-5 nm are purposely treated with highly concentrated aqueous NaBH4 solutions to obtain the reduced graphene quantum dots (rGQDs). Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS) and Raman spectroscopy demonstrate that the number of carbonyl groups decreases but -OH related defects increase during chemical reduction. Green and weak emissions of original GQDs originate from carrier recombination in the disorder-induced localized state (mainly including carbonyl and carboxyl and epoxy groups). As the reduction degree increases, the photoluminescence (PL) quantum efficiency of GQDs increases dramatically from 2.6% to 10.1%. In the meantime, the PL peak position blue shifts rapidly, and full width at half maximum (FWHM) becomes narrower. Thus we can infer that graphenol topological defects (hydroxyl functionalized graphene) are gradually formed during reduction. Besides, graphenol defect related PL features a longer fluorescence lifetime, excitation wavelength dependence but less pH sensitivity. PMID:26247890
Application of Chemically Accelerated Biotreatment to Reduce Risk in Oil-Impacted Soils
Paterek, J.R.; Bogan, W.W.; Sirivedhin; Tanita
2003-03-06
Research was conducted in six major focus areas: (1) Evaluation of the process using 6 test soils with full chemical and physical characteristics to determine controlling factors for biodegradation and chemical oxidation; (2) Determination of the sequestration time on chemical treatment suspectability; (3) Risk factors, i.e. toxicity after chemical and biological treatment; (4) Impact of chemical treatment (Fenton's Reagent) on the agents of biodegradation; (5) Description of a new genus and its type species that degrades hydrocarbons; and (6) Intermediates generate from Fenton's reagent treatment of various polynuclear aromatic hydrocarbons.
NASA Astrophysics Data System (ADS)
Barzel, Baruch; Biham, Ofer; Kupferman, Raz; Lipshtat, Azi; Zait, Amir
2010-08-01
Chemical reaction networks which exhibit strong fluctuations are common in microscopic systems in which reactants appear in low copy numbers. The analysis of these networks requires stochastic methods, which come in two forms: direct integration of the master equation and Monte Carlo simulations. The master equation becomes infeasible for large networks because the number of equations increases exponentially with the number of reactive species. Monte Carlo methods, which are more efficient in integrating over the exponentially large phase space, also become impractical due to the large amounts of noisy data that need to be stored and analyzed. The recently introduced multiplane method [A. Lipshtat and O. Biham, Phys. Rev. Lett. 93, 170601 (2004)10.1103/PhysRevLett.93.170601] is an efficient framework for the stochastic analysis of large reaction networks. It is a dimensional reduction method, based on the master equation, which provides a dramatic reduction in the number of equations without compromising the accuracy of the results. The reduction is achieved by breaking the network into a set of maximal fully connected subnetworks (maximal cliques). A separate master equation is written for the reduced probability distribution associated with each clique, with suitable coupling terms between them. This method is highly efficient in the case of sparse networks, in which the maximal cliques tend to be small. However, in dense networks some of the cliques may be rather large and the dimensional reduction is not as effective. Furthermore, the derivation of the multiplane equations from the master equation is tedious and difficult. Here we present the reduced-multiplane method in which the maximal cliques are broken down to the fundamental two-vertex cliques. The number of equations is further reduced, making the method highly efficient even for dense networks. Moreover, the equations take a simpler form, which can be easily constructed using a diagrammatic procedure
NASA Astrophysics Data System (ADS)
de-Campos, A. B.; Mamedov, A. I.; Huang, C.; Wagner, L. E.
2008-12-01
Upland soils in the Midwestern US often undergo reducing conditions when soils are temporally flooded during the spring and remain water saturated for days or weeks. Short-term reducing conditions change the chemistry of the soil and may affect soil structure and solution chemical transport. The effects of short-term reducing conditions on chemical and physical properties of the soils, colloids, and associated chemical/nutrients transport are still not well understood and was the objective of our study. A biogeochemical reactor was built to achieve reducing conditions. Three cultivated and three uncultivated soils with different organic carbon contents were incubated in the reactor for 1 hour and 3 days under anaerobic conditions. Effects of the redox state on soil structure (pore size distribution) and drainable porosity, colloids mobility, and chemical transport were determined using high energy moisture characteristic and analytical methods. After each treatment, the soil solution was collected for redox potential (Eh), pH, and electrical conductivity (EC) measurements, and chemical analysis of metals (Ca, Mg, K), nutrients (N, P), and dissolved organic carbon. Strongly reducing conditions were achieved after 3 days of incubation and were followed by a decrease in soil porosity and an increase in pH, EC, clay dispersion, swelling, colloids mobility, and associated chemical transport. The trend for each soil depended on their initial structural stability and chemical properties. The structure of cultivated soils and the leaching of nutrients and carbon from uncultivated soils were more sensitive to the redox state. A strong correlation was found between changes in Eh and drainable porosity. The role of short-term reducing conditions on changes in redox sensitive elements, organic matter decomposition, pH, and EC and their influence on soil structure and soil particles or colloids/chemical transport for both soil groups are discussed in the paper. This study
Reddy, R Vamshidhar; Tanveer, K; Sharma, K Dinesh; Kokkula, Naveen; Suresh, P L; Sudhakar, Meher
2013-11-01
Infection control requires serious effort in all fields of dentistry including orthodontics. Though there are various means of sterilization and disinfection in dental office, chemical disinfection is the most preferred method among orthodontists. The purpose of this study is to evaluate different chemical sterilization and disinfection methods used in orthodontic offices, which would guide the orthodontists in infection control.
Reducing the Risk of Dangerous Chemicals Getting into the Wrong Hands
ERIC Educational Resources Information Center
Matthews, Nancy
2008-01-01
Under the Department of Homeland Security (DHS) Appropriations Act of 2007, DHS has the authority and funding to regulate security at facilities storing chemicals considered to be high-risk (P. L. 109-295, Section 550). This article discusses the Department's efforts to enhance the security of facilities that store chemicals that could be stolen…
Guo, Xinghua; Bruins, Andries P; Covey, Thomas R
2007-06-01
The interference of chemical background ions (chemical noise) has been a problem since the inception of mass spectrometry. We present here a novel method to reduce the chemical noise in LC-MS based on exclusive gas-phase reactions with a reactive collision gas in a triple-quadrupole mass spectrometer. Combined with the zero neutral loss (ZNL) scan of a triple-quadrupole mass spectrometer, the reactive chemical noise ions can be removed because of shifts of mass-to-charge ratios from the original background ions. The test on various classes of compounds with different functional groups indicates a generic application of this technique in LC-MS. The preliminary results show that a reduction of the level of LC-MS base-peak chromatographic baseline by a factor up to 40 and an improvement of the signal-to-noise ratio by a factor up to 5-10 are achieved on both commercial and custom-modified triple-quadrupole LC-MS systems. Application is foreseen in both quantitative and qualitative trace analysis. It is expected that this chemical noise reduction technique can be optimized on a dedicated mass spectrometric instrumentation which incorporates both a chemical reaction cell for noise reduction and a collision stage for fragmentation.
NASA Astrophysics Data System (ADS)
Gao, Zhiming
2001-11-01
A phenomenological model based on the multizone concept and a three-dimensional CFD model were used to predict the effect of engine modification on particulated and NOx emission from a compression ignited direct injection (CIDI) engine. The phenomenological model consisted of a spray model, an evaporation model, a heat release model, NOx formation, soot formation, and oxidation model, and can be used to predict the combustion process and pollutant emission in a CIDI diesel engine. The advantage of the multizone model over the 3-D CFD model is the small CPU and memory it requires for a simulation. In this study, the phenomenological model was used to investigate (1) the effect of increasing the intake-air O2 content on soot and NO x emission as a function of power level and wall temperature; and (2) the effect of exhaust gas recirculation (EGR) and split fuel injection on pollutant emission, and compare their soot penalty at a given NOx emission. The results indicate that EGR with a relatively low temperature can reduce NOx emission with a minimum penalty of soot particle emission. The use of EGR is promising for significantly reducing NOx emission with small or no penalty of soot particle emission. The effect of auxiliary gas injection (AGI) on diesel engine combustion and emission was studied using KIVA 3V, a multidimensional computation fluid dynamics code. AGI enhances the diesel combustion via mixing to reduce the emission of pollutants. The simulation of a high-speed gas jet model with a relatively coarse computational grids was described. The choice of turbulent length scale for optimum simulation suitability is dependent of local mesh grid. The results demonstrate that AGI creates a second-way flow in the cylinder, which improves the mixing of charge in the cylinder. The effect of AGI on combustion and flow movement is significant. The use of exhaust gas on the AGI can reduce soot emission, while NOx emission also can be decreased to some degree. To reduce
Vats, Siddharth; Maurya, Devendra Prasad; Jain, Ayushi; Mall, Varija; Negi, Sangeeta
2013-11-01
The objective of this study was to optimize the physico-enzymatic pretreatment of P. roxburghii fallen foliage (needles) to produce reducing sugars through response surface methodology (RSM) with central composite face centered design (CCD). Under this, five parameters, i.e., concentration of laccase, cellulose and xylanase, steam explosion pressure and incubation period, at three levels with twenty six runs were taken into account. Cellulase, xylanase and laccase enzymes with activity 4.563, 38.32 and 0.05 IU/mL, respectively, were produced from locally isolated microbial strains. The analysis of variance (ANOVA) was applied for the validation of the predicted model at 95% of confidence level. This model predicted 334 mg/g release of reducing sugars on treating P. roxburghii fallen foliage with 1.18 mL of cellulose, 0.31 mL of xylanase and 0.01 mL of laccase, 14.39 psi steam explosion pressure and 24 h of incubation time. The experimental results obtained were in good agreement to predicted values, making it a reliable optimized model for five factors in combination to predict reducing sugar yield for ethanol production for bio-fuel industry.
NASA Astrophysics Data System (ADS)
Pham, Chuyen V.; Krueger, Michael; Eck, Michael; Weber, Stefan; Erdem, Emre
2014-03-01
Electron paramagnetic resonance (EPR) spectroscopy has been applied to different chemically treated reduced graphene oxide (rGO) and multiwalled carbon nanotubes (CNTs). A narrow EPR signal is visible at g = 2.0029 in both GO and CNT-Oxide from carbon-related dangling bonds. EPR signals became broader and of lower intensity after oxygen-containing functionalities were reduced and partially transformed into thiol groups to obtain thiol-functionalized reduced GO (TrGO) and thiol-functionalized CNT (CNT-SH), respectively. Additionally, EPR investigation of CdSe quantum dot-TrGO hybrid material reveals complete quenching of the TrGO EPR signal due to direct chemical attachment and electronic coupling. Our work confirms that EPR is a suitable tool to detect spin density changes in different functionalized nanocarbon materials and can contribute to improved understanding of electronic coupling effects in nanocarbon-nanoparticle hybrid nano-composites promising for various electronic and optoelectronic applications.
Reduced VOC chemical agent resistant coating (CARC). Progress report, October 1993-September 1994
Duncan, J.L.
1994-09-01
MIL-C-46168 is the basic camouflage topcoat required on all Army combat, combat support and essential ground support equipment, plus tactical wheeled vehicles and aircraft. Federal and local regulations resulting from the Clean Air Act and its amendments restrict the amount of Volatile Organic Compounds (VOCs) emitted during the application of surface coatings and there will be lower limits in the future. This report summarizes an effort to develop a lower-VOC CARC using recent technology advances in water-dispersable polyesters and polyisocyanates. While low-VOC, quality finishes have been developed, none has successfully passed live chemical agent resistance testing. Chemical Agent Resistant Coating, CARC, VOC.
APPLICATION OF CHEMICALLY ACCELERATED BIOTREATMENT TO REDUCE RISK IN OIL-IMPACTED SOILS
J.R. Paterek; W.W. Bogan; L.M. Lahner; A. May
2000-04-01
The overall program objective is to develop and evaluate integrated biological/physical/chemical co-treatment strategies for the remediation of wastes associated with the exploration and production of fossil energy. The specific objectives of this project are: chemical accelerated biotreatment (CAB) technology development for enhanced site remediation, application of the risk based analyses to define and support the rationale for environmental acceptable endpoints (EAE) for exploration and production wastes, and evaluate both the technological technologies in conjugation for effective remediation of hydrocarbon contaminated soils from E&P sites in the USA.
APPLICATION OF CHEMICALLY ACCELERATED BIOTREATMENT TO REDUCE RISK IN OIL-IMPACTED SOILS
J.R. Paterek; W.W. Bogan; L.M. Lahner; V. Trbovic; E. Korach
2001-05-01
The overall program objective is to develop and evaluate integrated biological/physical/chemical co-treatment strategies for the remediation of wastes associated with the exploration and production of fossil energy. The specific objectives of this project are: chemical accelerated biotreatment (CAB) technology development for enhanced site remediation, application of the risk based analyses to define and support the rationale for environmental acceptable endpoints (EAE) for exploration and production wastes, and evaluate both the technological technologies in conjugation for effective remediation of hydrocarbon contaminated soils from E&P sites in the USA.
Reducing Steam Pressure Saves $42,000 Annually at Vulcan Chemicals (VMC Geismar Plant)
2000-02-01
As part of their Operational Excellence Program, Vulcan Chemicals, a business group of the Vulcan Materials Company, implemented a process optimization project involving two chloromethane production units. This four-month project required no capital investment and resulted in a reduction in process steam demand and significant cost savings.
Innovative permeable cover system to reduce risks at a chemical munitions burial site
Powels, C.C.; Bon, I.; Okusu, N.M.
1997-12-31
An innovative permeable sand cover with various integrated systems has been designed to contain and treat the Old O-Field chemical munitions landfill at Aberdeen Proving Ground, Maryland. The 18,200 m{sup 2} (4.5 acre) landfill was used from the mid 1930s to the mid 1950s for the disposal of chemical, incendiary, and explosive munitions from domestic and foreign origins, together with contaminated wastes associated with the development and production of chemical warfare agents (CWA). The site is suspected to be contaminated with white phosphorous (WP) (which when dry, spontaneously burns when exposed to air), shock sensitive picric acid fuses and has the potential to contain large quantities of CWA-filled munitions. Historically, one to three explosions or fires occurred per ten-year period at the landfill. Such events have the potential to cause a CWA release to the environment, which could potentially affect densely populated areas. Recovery and decontamination projects conducted at the site in the late 1940s and early 1950s used large amounts of decontamination chemicals (containing solvents) and fuels which further contaminated the area. The groundwater downgradient of the landfill is contaminated with volatile organic compounds, metals, explosives and CWA degradation compounds and is currently being contained by a groundwater extraction and treatment system. This report describes a remedial action program for the site.
NASA Astrophysics Data System (ADS)
Aziz Ayyad, Ezzat
A mathematical representation is sought to model the behavior of a portable pneumatic foam bladder designed to mitigate the effects of human exposure to shock and whole body random vibration. Fluid Dynamics principles are used to derive the analytic differential equations used for the physical equations Model. Additionally, combination of Wiener and Hammerstein block oriented representation techniques have been selected to create system identification (SID) block oriented models. A number of algorithms have been iterated to obtain numerical solutions for the system of equations which was found to be coupled and non-linear, with no analytic closed form solution. The purpose is to be able to predict the response of such system due to random vibrations and shock within reasonable margin of error. The constructed models were found to be accurate within accepted confidence level. Beside the analytic set of physical equations model representation, a linear SID model was selected to take advantage of the available vast amount of mathematical tools available to further analyze and redesign the bladder as a dynamic system. Measured field-test and lab test data have been collected from several helicopter and land terrain vehicle experiments. Numerous excitation and response acceleration measurement records were collected and used to prove the agreement with predictions. The estimation of two selected models were later applied to standard metrics in the frequency domain realization and compared with measurement responses. The collected test records are obtained from measured data at the US Army fields and facilities and at UNLV-CMEST environmental lab. The emerged models have been validated for conformity with actual accelerometer measurement responses and found within accepted error tolerance that is in both time and frequency domains. Further, standard metrics have been used to further confirm the confidence in the validation results. When comparing model prediction with
Price, J.H. Jr.
1989-01-01
The work examines the engineering reasonableness and the cost effectiveness of reducing public exposure to carcinogens n ambient air by abating emissions of organic chemicals in waste gas streams from chemical plants in Harris County, Texas, which contains the large chemical manufacturing complex in the Houston ship channel areas. The work also examined the cost effectiveness of reducing public exposure through changing the way vent streams are released to the atmosphere. The achievable exposure reductions are estimated by use of 1980 census data and of ambient concentration estimates. The ambient concentration estimates are calculated using the Texas Climatological Model Version 2 (TCM-2) and publicly available emissions inventory collected by the Texas Air Control Board. The TCM-2 is based on the steady state Gaussian plume hypothesis, Briggs plume rise formations, Pasquill-Gifford dispersion coefficient approximations, and first order pollutant decay. The cost estimates rely on published studies and on the waste gas stream parameters of the chemical plant vents. The cost effectiveness results are compared with the cost effectiveness of controls typically applied to new sources of volatile organic compounds (VOCs) that are controlled because of their contribution to ozone air pollution, not because of the carcinogenicity of their emissions.
ERIC Educational Resources Information Center
Luther, Kenneth H.
2012-01-01
Mathematical modeling of groundwater flow is a topic at the intersection of mathematics and geohydrology and is rarely encountered in undergraduate mathematics. However, this subject is full of interesting and meaningful examples of truly "applied" mathematics accessible to undergraduates, from the pre-calculus to advanced mathematics levels. This…
A new rapid chemical route to prepare reduced graphene oxide using copper metal nanoparticles.
Wu, Tao; Gao, Jianping; Xu, Xiaoyang; Wang, Wei; Gao, Chunjuan; Qiu, Haixia
2013-05-31
Copper metal nanoparticles were used as a reducing agent to reduce graphene oxide (GO). The reaction was complete in about 10 min and did not involve the use of any toxic reagents or acids that are typically used in the reduction of GO by Zn and Fe powders. The high reduction activity of the Cu nanoparticles, compared to Cu powder, may be the result of the formation of Cu₂O nanoparticles. The effect of the mass ratio of the metal to GO for this reduction was also investigated. The reduction of the GO was verified by ultraviolet-visible absorption spectroscopy, x-ray diffraction, thermogravimetric analysis, Raman spectroscopy, x-ray photoelectron spectroscopy and transmission electron microscopy. After reduction, Cu₂O supported on reduced GO was formed and showed superior catalytic ability for the degradation of a model dye pollutant, methylene blue. PMID:23619742
A new rapid chemical route to prepare reduced graphene oxide using copper metal nanoparticles
NASA Astrophysics Data System (ADS)
Wu, Tao; Gao, Jianping; Xu, Xiaoyang; Wang, Wei; Gao, Chunjuan; Qiu, Haixia
2013-05-01
Copper metal nanoparticles were used as a reducing agent to reduce graphene oxide (GO). The reaction was complete in about 10 min and did not involve the use of any toxic reagents or acids that are typically used in the reduction of GO by Zn and Fe powders. The high reduction activity of the Cu nanoparticles, compared to Cu powder, may be the result of the formation of Cu2O nanoparticles. The effect of the mass ratio of the metal to GO for this reduction was also investigated. The reduction of the GO was verified by ultraviolet-visible absorption spectroscopy, x-ray diffraction, thermogravimetric analysis, Raman spectroscopy, x-ray photoelectron spectroscopy and transmission electron microscopy. After reduction, Cu2O supported on reduced GO was formed and showed superior catalytic ability for the degradation of a model dye pollutant, methylene blue.
Application of Chemically Accelerated Biotreatment to Reduce Risk in Oil-Impacted Soils
Paterek, J.R.; Bogan, W.W.; Lahner, L.M.; Trbovic, V.
2003-03-06
Conducted research in the following major focus areas: (1) Development of mild extraction approaches to estimate bioavailable fraction of crude oil residues in contaminated soils; (2) Application of these methods to understand decreases in toxicity and increases in sequestration of hydrocarbons over time, as well as the influence of soil properties on these processes; (3) Measurements of the abilities of various bacteria (PAH-degraders and others more representative of typical soil bacteria) to withstand oxidative treatments (i.e. Fenton's reaction) which would occur in CBT; and (4) Experiments into the biochemical/genetic inducibility of PAH degradation by compounds formed by the chemical oxidation of PAH.
1996-05-01
A biological/chemical process for converting cyclohexane into caprolactam was investigated: microorganisms in a bioreactor would be used to convert cyclohexane into caprolactone followed by chemical synthesis of caprolactam using ammonia. Four microorganisms were isolated from natural soil and water, that can utilize cyclohexane as a sole source of C and energy for growth. They were shown to have the correct metabolic intermediates and enzymes to convert cyclohexane into cyclohexanol, cyclohexanone, and caprolactone. Genetic techniques to create and select for caprolactone hydrolase negative-mutants were developed; those are used to convert cyclohexane into caprolactone but, because of the block, are unable to metabolize the caprolactone further. Because of a new nylon carpet reycle process and the long time frame for a totally new bioprocess, a limited study was done to evaluate whether a simplified bioprocess to convert cyclohexanol into cyclohexanone or caprolactone was feasible; growth rates and key enzyme levels were measured in a collection of microorganisms that metabolize cyclohexanol to determine if the bioactivity is high enough to support an economical cyclohexanol bioprocess. Although these microorganisms had sufficient bioactivity, they could tolerate only low levels (<1%) of cyclohexanol and thus are not suitable for developing a cost effective bioprocess because of the high cost of dilute product recovery.
Tucker, Mark D.
2014-06-03
A reduced weight DF-200 decontamination formulation that is stable under high temperature storage conditions. The formulation can be pre-packed as an all-dry (i.e., no water) or nearly-dry (i.e., minimal water) three-part kit, with make-up water (the fourth part) being added later in the field at the point of use.
Downscaling procedures reduce chemical use in androgen receptor reporter gene assay.
Di Paolo, Carolina; Kirchner, Kristina; Balk, Fabian Gerhard Peter; Muschket, Matthias; Brack, Werner; Hollert, Henner; Seiler, Thomas-Benjamin
2016-11-15
Bioactivity screening studies often face sample amount limitation with respect to the need for reliable, reproducible and quantitative results. Therefore approaches that minimize sample use are needed. Low-volume exposure and chemical dilution procedures were applied in an androgen receptor reporter gene human cell line assay to evaluate environmental contaminants and androgen receptor modulators, which were the agonist 5α-dihydrotestosterone (DHT); and the antagonists flutamide, bisphenol A, 1-hydroxypyrene and triclosan. Cells were exposed in around 1/3 of the medium volume recommended by the protocol (70μL/well). Further, chemical losses during pipetting steps were minimized by applying a low-volume method for compound dilution in medium (250μL for triplicate wells) inside microvolume glass inserts. Simultaneously, compounds were evaluated following conventional procedures (200μL/well, dilution in 24-well plates) for comparison of results. Low-volume exposure tests produced DHT EC50 (3.4-3.7×10(-10)M) and flutamide IC50 (2.2-3.3×10(-7)M) values very similar to those from regular assays (3.1-4.2×10(-10) and 2.1-3.3×10(-7)M respectively) and previous studies. Also, results were within assay acceptance criteria, supporting the relevance of the downscaling setup for agonistic and antagonistic tests. The low-volume exposure was also successful in determining IC50 values for 1-hydroxypyrene (2.1-2.8×10(-6)M), bisphenol A (2.6-3.3×10(-6)M), and triclosan (1.2-1.9×10(-6)M) in agreement with values obtained through high-volume exposure (2.3-2.8, 2.5-3.4 and 1.0-1.3×10(-6)M respectively). Finally, experiments following both low-volume dosing and exposure produced flutamide and triclosan IC50 values similar to those from regular tests. The low-volume experimental procedures provide a simple and effective solution for studies that need to minimize bioassay sample use while maintaining method reliability. The downscaling methods can be applied for the evaluation
Montgomery, Christopher J.; Yang, Chongguan; Parkinson, Alan R.; Chen, J.-Y.
2006-01-01
A genetic optimization algorithm has been applied to the selection of quasi-steady-state (QSS) species in reduced chemical kinetic mechanisms. The algorithm seeks to minimize the error between reduced and detailed chemistry for simple reactor calculations approximating conditions of interest for a computational fluid dynamics simulation. The genetic algorithm does not guarantee that the global optimum will be found, but much greater accuracy can be obtained than by choosing QSS species through a simple kinetic criterion or by human trial and error. The algorithm is demonstrated for methane-air combustion over a range of temperatures and stoichiometries and for homogeneous charge compression ignition engine combustion. The results are in excellent agreement with those predicted by the baseline mechanism. A factor of two reduction in the number of species was obtained for a skeletal mechanism that had already been greatly reduced from the parent detailed mechanism.
Gary D. McGinnis
2001-12-31
The research is a laboratory and bench-scale investigation of a system to concentrate and destroy volatile organic compounds (VOCs), including hazardous air pollutants, formed from the drying of wood and the manufacture of wood board products (e.g., particle board and oriented strandboard). The approach that was investigated involved concentrating the dilute VOCs (<500 ppmv) with a physical/chemical adsorption unit, followed by the treatment of the concentrated voc stream (2,000 to 2,500 ppmv) with a biofiltration unit. The research program lasted three years, and involved three research organizations. Michigan Technological University was the primary recipient of the financial assistance, the USDA Forest Products Laboratory (FPL) and Mississippi State University (MSU) were subcontractors to MTU. The ultimate objective of this research was to develop a pilot-scale demonstration of the technology with sufficient data to provide for the design of an industrial system. No commercialization activities were included in this project.
APPLICATION OF CHEMICALLY ACCELERATED BIOTREATMENT TO REDUCE RISKIN OIL-IMPACTED SOILS
J.R. Paterek; W.W.Bogan; V. Trbovic; W. Sullivan
2003-01-07
The drilling and operation of gas/petroleum exploratory wells and the operations of natural gas and petroleum production wells generate a number of waste materials that are usually stored and/or processed at the drilling/operations site. Contaminated soils result from drilling operations, production operations, and pipeline breaks or leaks where crude oil and petroleum products are released into the surrounding soil or sediments. In many cases, intrinsic biochemical remediation of these contaminated soils is either not effective or is too slow to be an acceptable approach. This project targeted petroleum-impacted soil and other wastes, such as soil contaminated by: accidental release of petroleum and natural gas-associated organic wastes from pipelines or during transport of crude oil or natural gas; production wastes (such as produced waters, and/or fuels or product gas). Our research evaluated the process designated Chemically-Accelerated Biotreatment (CAB) that can be applied to remediate contaminated matrices, either on-site or in situ. The Gas Technology Institute (GTI) had previously developed a form of CAB for the remediation of hydrocarbons and metals at Manufactured Gas Plant (MGP) sites and this research project expanded its application into Exploration and Production (E&P) sites. The CAB treatment was developed in this project using risk-based endpoints, a.k.a. environmentally acceptable endpoints (EAE) as the treatment goal. This goal was evaluated, compared, and correlated to traditional analytical methods (Gas Chromatography (GC), High Precision Liquid Chromatography (HPLC), or Gas Chromatography-Mass Spectrometry (CGMS)). This project proved that CAB can be applied to remediate E&P contaminated soils to EAE, i.e. those concentrations of chemical contaminants in soil below which there is no adverse affect to human health or the environment. Conventional approaches to risk assessment to determine ''how clean is clean'' for soils undergoing remediation
Reducing flicker noise in chemical vapor deposition graphene field-effect transistors
NASA Astrophysics Data System (ADS)
Arnold, Heather N.; Sangwan, Vinod K.; Schmucker, Scott W.; Cress, Cory D.; Luck, Kyle A.; Friedman, Adam L.; Robinson, Jeremy T.; Marks, Tobin J.; Hersam, Mark C.
2016-02-01
Single-layer graphene derived from chemical vapor deposition (CVD) holds promise for scalable radio frequency (RF) electronic applications. However, prevalent low-frequency flicker noise (1/f noise) in CVD graphene field-effect transistors is often up-converted to higher frequencies, thus limiting RF device performance. Here, we achieve an order of magnitude reduction in 1/f noise in field-effect transistors based on CVD graphene transferred onto silicon oxide substrates by utilizing a processing protocol that avoids aqueous chemistry after graphene transfer. Correspondingly, the normalized noise spectral density (10-7-10-8 μm2 Hz-1) and noise amplitude (4 × 10-8-10-7) in these devices are comparable to those of exfoliated and suspended graphene. We attribute the reduction in 1/f noise to a decrease in the contribution of fluctuations in the scattering cross-sections of carriers arising from dynamic redistribution of interfacial disorder.
Mason, Charles J; Couture, John J; Raffa, Kenneth F
2014-07-01
Phytophagous insects must contend with numerous secondary defense compounds that can adversely affect their growth and development. The gypsy moth (Lymantria dispar) is a polyphagous herbivore that encounters an extensive range of hosts and chemicals. We used this folivore and a primary component of aspen chemical defenses, namely, phenolic glycosides, to investigate if bacteria detoxify phytochemicals and benefit larvae. We conducted insect bioassays using bacteria enriched from environmental samples, analyses of the microbial community in the midguts of bioassay larvae, and in vitro phenolic glycoside metabolism assays. Inoculation with bacteria enhanced larval growth in the presence, but not absence, of phenolic glycosides in the artificial diet. This effect of bacteria on growth was observed only in larvae administered bacteria from aspen foliage. The resulting midgut community composition varied among the bacterial treatments. When phenolic glycosides were included in diet, the composition of midguts in larvae fed aspen bacteria was significantly altered. Phenolic glycosides increased population responses by bacteria that we found able to metabolize these compounds in liquid growth cultures. Several aspects of these results suggest that vectoring or pairwise symbiosis models are inadequate for understanding microbial mediation of plant-herbivore interactions in some systems. First, bacteria that most benefitted larvae were initially foliar residents, suggesting that toxin-degrading abilities of phyllosphere inhabitants indirectly benefit herbivores upon ingestion. Second, assays with single bacteria did not confer the benefits to larvae obtained with consortia, suggesting multi- and inter-microbial interactions are also involved. Our results show that bacteria mediate insect interactions with plant defenses but that these interactions are community specific and highly complex. PMID:24798201
Evaluation of chemical amendments to reduce ammonia volatilization from poultry litter.
Moore, P A; Daniel, T C; Edwards, D R; Miller, D M
1996-03-01
Ammonia volatilization from poultry litter often causes high levels of atmospheric ammonia in poultry houses, which is detrimental to both farm workers and birds. Ammonia emissions from houses also aggravate environmental problems, such as acid rain, and result in a loss of fertilizer nitrogen. The objectives of this study were to determine the effect of litter amendments on ammonia volatilization and to determine the effect of these amendments on nitrogen and phosphorus content in litter. The results of this research indicate that alum [Al2(SO4)3.18H2O], ferrous sulfate (FeSO4.7H2O), and phosphoric acid (H3PO4) dramatically reduce ammonia volatilization form litter. The amount of ammonia lost from litter treated with sodium bisulfate (NaHSO4) and a proprietory product made of Ca-Fe silicate with a phosphoric acid coating was not different from the control (untreated litter). Aluminum sulfate (alum) and ferrous sulfate also reduced water soluble P concentrations in litter, whereas phosphoric acid greatly increased water-soluble P levels. The most effective compound evaluated with respect to reducing both ammonia loss and P solubility was alum.
Synthesis of reduced graphene oxide (rGO) via chemical reduction
Thakur, Alpana Rangra, V. S.; Kumar, Sunil
2015-05-15
Natural flake Graphite was used as the starting material for the graphene synthesis. In the first step flake graphite was treated with oxidizing agents under vigorous conditions to obtain graphite oxide. Layered graphite oxide decorated with oxygen has large inter-layer distance leading easy exfoliation into single sheets by ultrasonication giving graphene oxide. In the last step exfoliated graphene oxide sheets were reduced slowly with the help of reducing agent to obtain fine powder which is labeled as reduced graphene oxide (rGO). This rGO was further characterized by X-Ray Diffraction (XRD), Scanning Tunneling Microscopy (SEM) and Fourier Transform Infrared Spectroscopy (FTIR), Raman Spectroscopy techniques. XRD pattern shows peaks corresponding to (002) graphitic lattice planes indicating the formation of network of sp{sup 2} like carbon structure. SEM images show the ultrathin, wrinkled, paper-like morphology of graphene sheets. IR study shows that the graphite has been oxidized to graphite oxide with the presence of various absorption bands confirming the presence of oxidizing groups. The FTIR spectrum of rGO shows no sharp peaks confirming the efficient reduction of rGO. The Raman spectrum shows disorder in the graphene sheets.
NASA Astrophysics Data System (ADS)
Jana, Milan; Kumar, J. Sharath; Khanra, Partha; Samanta, Pranab; Koo, Hyeyoung; Murmu, Naresh Chandra; Kuila, Tapas
2016-01-01
A novel strategy to synthesize hierarchical rod like MnCO3 on the reduced graphene oxide (RGO) sheets by a facile and cost-effective hydrothermal method is demonstrated. The chelating action of citric acid facilitates the formation a complex intermediate of Mn2+ and citrate ions, which finally results a 3D MnCO3/RGO (MRGO) composite with high electrical conductivity (˜1056 S m-1), good surface area (59 m2 g-1) and high pore volume (0.3 cm3 g-1). The specific capacitance (SC) of the MRGO composite is ˜1120 F g-1 at a current density of 2 A g-1 in three electrode system. An asymmetric device has been designed with MRGO as positive and sono-chemically reduced RGO (SRGO) as negative electrode material. The asymmetric device (MRGO//SRGO) shows the SC of ˜318 F g-1 (at 2 A g-1) and energy density of ˜113 W h kg-1 (at 1600 W kg-1). The true energy density (1.7 W h kg-1) has been calculated considering the total weight of the device. The MRGO//SRGO device can power a wall clock for ˜13 min after full charging. The Nyquist plot of the asymmetric cell has been simulated with Z-View software to measure the solution resistance, charge-transfer resistance and Warburg elements.
Plant growth-promoting rhizobacteria allow reduced application rates of chemical fertilizers.
Adesemoye, A O; Torbert, H A; Kloepper, J W
2009-11-01
The search for microorganisms that improve soil fertility and enhance plant nutrition has continued to attract attention due to the increasing cost of fertilizers and some of their negative environmental impacts. The objectives of this greenhouse study with tomato were to determine (1) if reduced rates of inorganic fertilizer coupled with microbial inoculants will produce plant growth, yield, and nutrient uptake levels equivalent to those with full rates of the fertilizer and (2) the minimum level to which fertilizer could be reduced when inoculants were used. The microbial inoculants used in the study were a mixture of plant growth-promoting rhizobacteria (PGPR) strains Bacillus amyloliquefaciens IN937a and Bacillus pumilus T4, a formulated PGPR product, and the arbuscular mycorrhiza fungus (AMF), Glomus intraradices. Results showed that supplementing 75% of the recommended fertilizer rate with inoculants produced plant growth, yield, and nutrient (nitrogen and phosphorus) uptake that were statistically equivalent to the full fertilizer rate without inoculants. When inoculants were used with rates of fertilizer below 75% of the recommended rate, the beneficial effects were usually not consistent; however, inoculation with the mixture of PGPR and AMF at 70% fertility consistently produced the same yield as the full fertility rate without inoculants. Without inoculants, use of fertilizer rates lower than the recommended resulted in significantly less plant growth, yield, and nutrient uptake or inconsistent impacts. The results suggest that PGPR-based inoculants can be used and should be further evaluated as components of integrated nutrient management strategies. PMID:19466478
Thatcher, Tracy L.; Daisey, Joan M.
1999-09-01
There is growing concern about potential terrorist attacks involving releases of chemical and/or biological (CB) agents, such as sarin or anthrax, in and around buildings. For an external release, the CB agent can enter the building through the air intakes of a building's mechanical ventilation system and by infiltration through the building envelope. For an interior release in a single room, the mechanical ventilation system, which often recirculates some fraction of the air within a building, may distribute the released CB agent throughout the building. For both cases, installing building systems that remove chemical and biological agents may be the most effective way to protect building occupants. Filtration systems installed in the heating, ventilating and air-conditioning (HVAC) systems of buildings can significantly reduce exposures of building occupants in the event of a release, whether the release is outdoors or indoors. Reduced exposures can reduce the number of deaths from a terrorist attack. The purpose of this report is to provide information and examples of the design of filtration systems to help building engineers retrofit HVAC systems. The report also provides background information on the physical nature of CB agents and brief overviews of the basic principles of particle and vapor filtration.
Pham, Chuyen V.; Krueger, Michael E-mail: emre.erdem@physchem.uni-freiburg.de; Eck, Michael; Weber, Stefan; Erdem, Emre E-mail: emre.erdem@physchem.uni-freiburg.de
2014-03-31
Electron paramagnetic resonance (EPR) spectroscopy has been applied to different chemically treated reduced graphene oxide (rGO) and multiwalled carbon nanotubes (CNTs). A narrow EPR signal is visible at g = 2.0029 in both GO and CNT-Oxide from carbon-related dangling bonds. EPR signals became broader and of lower intensity after oxygen-containing functionalities were reduced and partially transformed into thiol groups to obtain thiol-functionalized reduced GO (TrGO) and thiol-functionalized CNT (CNT-SH), respectively. Additionally, EPR investigation of CdSe quantum dot-TrGO hybrid material reveals complete quenching of the TrGO EPR signal due to direct chemical attachment and electronic coupling. Our work confirms that EPR is a suitable tool to detect spin density changes in different functionalized nanocarbon materials and can contribute to improved understanding of electronic coupling effects in nanocarbon-nanoparticle hybrid nano-composites promising for various electronic and optoelectronic applications.
Chemical vapor deposition of hexagonal boron nitride films in the reduced pressure
Choi, B.J.
1999-12-01
Hexagonal boron nitride (h-BN) films were deposited onto a graphite substrate in reduced pressure by reacting ammonia and boron tribromide at 800--1,200 C. The growth rate of h-BN films was dependent on the substrate temperature and the total pressures. The growth rate increased with increasing the substrate temperature at the pressure of 2 kPa, while it showed a maximum value at the pressures of 4 and 8 kPa. The temperature at which the maximum growth rate occurs decreased with increasing total pressure. With increasing the substrate temperature and total pressure, the apparent grain size increased and the surface morphology showed a rough, cauliflower-like structure.
Physical and chemical evolution of reduced organic matter in the ISM
NASA Technical Reports Server (NTRS)
Jenniskens, Peter; Blake, David F.
1995-01-01
Icy mantles on interstellar grains have been a topic of study in airborne astronomy. Recent laboratory analog studies of the yield of organic residue from UV photolyzed ices have shown that this mechanism can be the most significant source of complex reduced organic matter in the interstellar medium. However, the total yield is a function of the occurrence of heating events that evaporate the ice, i.e. T is greater than 130 K, and the mechanism for such events is debated. Recently, we proposed that the recombination of radicals in the ice does not need high temperature excursions and, instead, occurs during a structural transformation of water ice at temperatures in the range 38 - 68 K.
NASA Technical Reports Server (NTRS)
Unuvar, C.; Fredrick, D.; Anselmi-Tamburini, U.; Manerbino, A.; Guigne, J. Y.; Munir, Z. A.; Shaw, B. D.
2004-01-01
Combustion synthesis (CS) generally involves mixing reactants together (e.g., metal powders) and igniting the mixture. Typically, a reaction wave will pass through the sample. In field activated combustion synthesis (FACS), the addition of an electric field has a marked effect on the dynamics of wave propagation and on the nature, composition, and homogeneity of the product as well as capillary flow, mass-transport in porous media, and Marangoni flows, which are influenced by gravity. The objective is to understand the role of an electric field in CS reactions under conditions where gravity-related effects are suppressed or altered. The systems being studied are Ti+Al and Ti+3Al. Two different ignition orientations have been used to observe effects of gravity when one of the reactants becomes molten. This consequentially influences the position and concentration of the electric current, which in turn influences the entire process. Experiments have also been performed in microgravity conditions. This process has been named Microgravity Field Activated Combustion Synthesis (MFACS). Effects of gravity have been demonstrated, where the reaction wave temperature and velocity demonstrate considerable differences besides the changes of combustion mechanisms with the different high currents applied. Also the threshold for the formation of a stable reaction wave is increased under zero gravity conditions. Electric current was also utilized with a chemical oven technique, where inserts of aluminum with minute amounts of tungsten and tantalum were used to allow observation of effects of settling of the higher density solid particles in liquid aluminum at the present temperature profile and wave velocity of the reaction.
Kasper, Stephen H; Bonocora, Richard P; Wade, Joseph T; Musah, Rabi Ann; Cady, Nathaniel C
2016-04-15
The opportunistic pathogen Pseudomonas aeruginosa utilizes multiple quorum sensing (QS) pathways to coordinate an arsenal of virulence factors. We previously identified several cysteine-based compounds inspired by natural products from the plant Petiveria alliacea which are capable of antagonizing multiple QS circuits as well as reducing P. aeruginosa biofilm formation. To understand the global effects of such compounds on virulence factor production and elucidate their mechanism of action, RNA-seq transcriptomic analysis was performed on P. aeruginosa PAO1 exposed to S-phenyl-l-cysteine sulfoxide, the most potent inhibitor from the prior study. Exposure to this inhibitor down-regulated expression of several QS-regulated virulence operons (e.g., phenazine biosynthesis, type VI secretion systems). Interestingly, many genes that were differentially regulated pertain to the related metabolic pathways that yield precursors of pyochelin, tricarboxylic acid cycle intermediates, phenazines, and Pseudomonas quinolone signal (PQS). Activation of the MexT-regulon was also indicated, including the multidrug efflux pump encoded by mexEF-oprN, which has previously been shown to inhibit QS and pathogenicity. Deeper investigation of the metabolites involved in these systems revealed that S-phenyl-l-cysteine sulfoxide has structural similarity to kynurenine, a precursor of anthranilate, which is critical for P. aeruginosa virulence. By supplementing exogenous anthranilate, the QS-inhibitory effect was reversed. Finally, it was shown that S-phenyl-l-cysteine sulfoxide competitively inhibits P. aeruginosa kynureninase (KynU) activity in vitro and reduces PQS production in vivo. The kynurenine pathway has been implicated in P. aeruginosa QS and virulence factor expression; however, this is the first study to show that targeted inhibition of KynU affects P. aeruginosa gene expression and QS, suggesting a potential antivirulence strategy.
Kasper, Stephen H; Bonocora, Richard P; Wade, Joseph T; Musah, Rabi Ann; Cady, Nathaniel C
2016-04-15
The opportunistic pathogen Pseudomonas aeruginosa utilizes multiple quorum sensing (QS) pathways to coordinate an arsenal of virulence factors. We previously identified several cysteine-based compounds inspired by natural products from the plant Petiveria alliacea which are capable of antagonizing multiple QS circuits as well as reducing P. aeruginosa biofilm formation. To understand the global effects of such compounds on virulence factor production and elucidate their mechanism of action, RNA-seq transcriptomic analysis was performed on P. aeruginosa PAO1 exposed to S-phenyl-l-cysteine sulfoxide, the most potent inhibitor from the prior study. Exposure to this inhibitor down-regulated expression of several QS-regulated virulence operons (e.g., phenazine biosynthesis, type VI secretion systems). Interestingly, many genes that were differentially regulated pertain to the related metabolic pathways that yield precursors of pyochelin, tricarboxylic acid cycle intermediates, phenazines, and Pseudomonas quinolone signal (PQS). Activation of the MexT-regulon was also indicated, including the multidrug efflux pump encoded by mexEF-oprN, which has previously been shown to inhibit QS and pathogenicity. Deeper investigation of the metabolites involved in these systems revealed that S-phenyl-l-cysteine sulfoxide has structural similarity to kynurenine, a precursor of anthranilate, which is critical for P. aeruginosa virulence. By supplementing exogenous anthranilate, the QS-inhibitory effect was reversed. Finally, it was shown that S-phenyl-l-cysteine sulfoxide competitively inhibits P. aeruginosa kynureninase (KynU) activity in vitro and reduces PQS production in vivo. The kynurenine pathway has been implicated in P. aeruginosa QS and virulence factor expression; however, this is the first study to show that targeted inhibition of KynU affects P. aeruginosa gene expression and QS, suggesting a potential antivirulence strategy. PMID:26785289
ERIC Educational Resources Information Center
Reys, Robert; Reys, Rustin
2011-01-01
In their dual roles as mathematics teachers and tennis coaches, the authors have worked with tennis players who have never thought about how a knowledge of mathematics might help them become "better" tennis players. They have also worked with many mathematics students who have never considered how much mathematics is associated with tennis. This…
Kantrowitz, I.H.; Woodham, W.M.
1995-01-01
A multipurpose wet stormwater detention pond in Pinellas Park, Florida was studied to determine its effectiveness in reducing the load of selected water-quality constituents commonly found in urban streamflow. Water-quality samples, and data on streamflow and precipitation were collected at the outflow and principal inflow of detention area 3 on Saint Joe Creek. To compare the constituent loads entering and leaving the detention pond, flows and water quality were monitored simultaneously at the inflow and outflow sites for six storms, and were monitored intermittently during periods of base flow. Lodas od 19 selected chemical and physical constituents were determined. Because all the stormwater entering the detention pond was not measured at the inflow site, computed stormwater inflow loads were adjusted to account for loads from the unmonitored areas. The ratio of storm- water volume measured at the outflow site to stormwater volume measured at the inflow site was used to adjust inflow loads for individual storms. Pond efficiencies for selected water- quality constituents for each of the storms were estimated by dividing the difference in outflow and adjusted inflow loads by the adjusted inflow load. Stormwater loads of the major ions (chloride, calcium and bicarbonate) and dissolved solids at the outflow site exceeded loads at the inflow site, partly as a result of mixing with base flow stored within the pond. However, the detention pond was effective in reducing the stormwater load of such urban-runoff contaminants as metals, nutrients, suspended solids, and biochemical and chemical oxygen demand. Estimated median pond efficiencies for reducing constituent loads ranged from 25 to more than 60 percent for metals, 2 to 52 percent for nutrients, 2 to 52 percent for nutrients, 7 to 11 percent for two measurements of suspended solids, and 16 to 49 percent for the oxygen- consuming substances. The reductions of constituent loads in stormwater are probably a result of
Grdina, D.J.
1986-01-01
We have investigated WR2721 and similar aminothiol compounds to determine their role in modulating the mutagenic and carcinogenic action of radiation and selected chemotherapeutic agents. We have found that 2-((aminopropyl)amino) ethanethiol (WR1065), a free-thiol of WR2721, effectively protected against the mutagenic effects of radiation at the HGPRT locus in V79 cells even if administered up to 3 h following irradiation, a reduction in mutation frequencies of about 0.55. Under the conditions tested, the radioprotector protected against cell killing only if it was present during irradiation. In contrast, protection against mutagenesis occurred regardless of whether the protector was present during or following irradiation. These preliminary studies were expanded to determine the effects of WR1065 on cis-diamminedichloroplatinum-(cis-DDP) and bleomycin-induced cytotoxicity and mutagenicity even when administered following chemotherapy treatment. Thus, the V79 cell system used was found to be extremely effective in monitoring, in a rapid and cost-effective manner, the antimutagenic effects of radioprotectors on radiation and chemotherapy agents. Cell transformation was assayed using C3H 10T1/2 cells. The presence of a radioprotector significantly reduced the formation of radiation-induced transformed cells. Neonatal rats were also used to assess the induction of preneoplastic-lesions. 6 figs., 1 tab.
Chemical genoprotection: reducing biological damage to as low as reasonably achievable levels
Alcaraz, M; Armero, D; Martínez-Beneyto, Y; Castillo, J; Benavente-García, O; Fernandez, H; Alcaraz-Saura, M; Canteras, M
2011-01-01
Objectives The aim of this study was to evaluate the antioxidant substances present in the human diet with an antimutagenic protective capacity against genotoxic damage induced by exposure to X-rays in an attempt to reduce biological damage to as low a level as reasonably possible. Methods Ten compounds were assessed using the lymphocyte cytokinesis-block micronucleus (MN) cytome test. The compounds studied were added to human blood at 25 μM 5 min before exposure to irradiation by 2 Gy of X-rays. Results The protective capacity of the antioxidant substances assessed was from highest to lowest according to the frequency of the MN generated by X-ray exposure: rosmarinic acid = carnosic acid = δ-tocopherol = l-acid ascorbic = apigenin = amifostine (P < 0.001) > green tea extract = diosmine = rutin = dimetylsulfoxide (P < 0.05) > irradiated control. The reduction in genotoxic damage with the radiation doses administered reached 58%, which represents a significant reduction in X-ray-induced chromosomal damage (P < 0.001). This degree of protection is greater than that obtained with amifostine, a radioprotective compound used in radiotherapy and which is characterised by its high toxicity. Conclusion Several antioxidant substances, common components of the human diet and lacking toxicity, offer protection from the biological harm induced by ionizing radiation. Administering these protective substances to patients before radiological exploration should be considered, even in the case of small radiation doses and regardless of the biological damage expected. PMID:21697157
Yoder, Sally F; Henning, William R; Mills, Edward W; Doores, Stephanie; Ostiguy, Nancy; Cutter, Catherine N
2012-01-01
Numerous antimicrobial interventions are capable of reducing the prevalence of harmful bacteria on raw meat products. There is a need to identify effective and inexpensive antimicrobial interventions that could, in practice, be used in very small meat plants because of limited financial, space, and labor resources. Eight antimicrobial compounds (acetic acid, citric acid, lactic acid, peroxyacetic acid, acidified sodium chlorite, chlorine dioxide, sodium hypochlorite, and aqueous ozone) were applied at various concentrations with small, hand-held spraying equipment, and bactericidal effectiveness was examined. Beef plate pieces were inoculated with fecal slurry containing a pathogen cocktail (Escherichia coli O157:H7, Salmonella Typhimurium, Campylobacter coli, and Campylobacter jejuni) and natural populations of aerobic plate counts, coliforms, and E. coli. Antimicrobial solutions were applied to beef surfaces via a portable, pressurized hand-held spray tank, and treated surfaces were subjected to appropriate methods for the enumeration and isolation of pathogens and hygiene indicators. Relative antimicrobial effectiveness was determined (from greatest to least): (i) organic acids, (ii) peroxyacetic acid, (iii) chlorinated compounds, and (iv) aqueous ozone. Using the equipment described, a 2% lactic acid rinse provided 3.5- to 6.4-log CFU/cm(2) reductions across all bacterial populations studied. Conversely, aqueous ozone yielded 0.02- to 2.9-log CFU/cm(2) reductions in pathogens and hygiene indicators, and did not differ significantly from a control tap water rinse (P = 0.055 to 0.731). This 2% lactic acid rinse will be subsequently combined with a previously described water wash to create a multistep antimicrobial intervention that will be examined under laboratory conditions and validated in very small meat plants. PMID:22221350
Duan, Yinghua; Xu, Minggang; Gao, Suduan; Liu, Hua; Huang, Shaomin; Wang, Boren
2016-01-01
Improving soil fertility/productivity and reducing environmental impact of nitrogen (N) fertilization are essential for sustainable agriculture. Quantifying the contribution of various fertilization regimes to soil N storage and loss has been lacking in a wide range of spatiotemporal scales. Based on data collected from field experiments at three typical agricultural zones in China, soil N dynamics and N changes in soil profile (0-100 cm) were examined during 1990-2009 under chemical fertilization, manure incorporation with fertilizer, and fertilizer with straw return treatments. We employed a mass balance approach to estimate the N loss to the environment after taking into account soil N change. Results showed a significant increase in soil N storage under manure incorporation treatments, accompanied with the lowest N loss (ave.20-24% of total N input) compared to all other treatments (ave.35-63%). Both soil N distribution and mass balance data suggested higher leaching risk from chemical fertilization in acidic soil of southern China with higher precipitation than the other two sites. This research concludes that manure incorporation with chemical fertilizer not only can achieve high N use efficiency and improve soil fertility, but also leads to the lowest total N loss or damage to the environment. PMID:27650801
NASA Astrophysics Data System (ADS)
Duan, Yinghua; Xu, Minggang; Gao, Suduan; Liu, Hua; Huang, Shaomin; Wang, Boren
2016-09-01
Improving soil fertility/productivity and reducing environmental impact of nitrogen (N) fertilization are essential for sustainable agriculture. Quantifying the contribution of various fertilization regimes to soil N storage and loss has been lacking in a wide range of spatiotemporal scales. Based on data collected from field experiments at three typical agricultural zones in China, soil N dynamics and N changes in soil profile (0–100 cm) were examined during 1990–2009 under chemical fertilization, manure incorporation with fertilizer, and fertilizer with straw return treatments. We employed a mass balance approach to estimate the N loss to the environment after taking into account soil N change. Results showed a significant increase in soil N storage under manure incorporation treatments, accompanied with the lowest N loss (ave.20–24% of total N input) compared to all other treatments (ave.35–63%). Both soil N distribution and mass balance data suggested higher leaching risk from chemical fertilization in acidic soil of southern China with higher precipitation than the other two sites. This research concludes that manure incorporation with chemical fertilizer not only can achieve high N use efficiency and improve soil fertility, but also leads to the lowest total N loss or damage to the environment.
Duan, Yinghua; Xu, Minggang; Gao, Suduan; Liu, Hua; Huang, Shaomin; Wang, Boren
2016-01-01
Improving soil fertility/productivity and reducing environmental impact of nitrogen (N) fertilization are essential for sustainable agriculture. Quantifying the contribution of various fertilization regimes to soil N storage and loss has been lacking in a wide range of spatiotemporal scales. Based on data collected from field experiments at three typical agricultural zones in China, soil N dynamics and N changes in soil profile (0–100 cm) were examined during 1990–2009 under chemical fertilization, manure incorporation with fertilizer, and fertilizer with straw return treatments. We employed a mass balance approach to estimate the N loss to the environment after taking into account soil N change. Results showed a significant increase in soil N storage under manure incorporation treatments, accompanied with the lowest N loss (ave.20–24% of total N input) compared to all other treatments (ave.35–63%). Both soil N distribution and mass balance data suggested higher leaching risk from chemical fertilization in acidic soil of southern China with higher precipitation than the other two sites. This research concludes that manure incorporation with chemical fertilizer not only can achieve high N use efficiency and improve soil fertility, but also leads to the lowest total N loss or damage to the environment. PMID:27650801
Kim, Sujin; Choi, Kwangrok; Shim, Yeonjun; Lee, Seungjun; Park, Sungjin
2016-08-01
Reduced graphene oxide (rG-O)-based materials have great potential as metal-free electrocatalysts for the oxygen reduction reaction (ORR) owing to their electrical and electrochemical properties and large surface area. Long-term durability and chemical stability of the catalysts in the presence of electrolytes such as aqueous KOH solution are important for their use in practical applications. In this study, three types of rG-O and rG-O-K (rG-O after reaction with KOH) materials were synthesized. The chemical structures, surface areas, and catalytic ORR performances of the rG-O materials were compared with those of the corresponding rG-O-K materials. The onset potentials of the rG-O materials for electrocatalytic reduction of oxygen are almost the same as those of the corresponding rG-O-K materials; however, the current density and the number of transferred electrons are significantly reduced. These data show that the catalytic ORR performance of rG-O-based materials can be altered by KOH.
NASA Astrophysics Data System (ADS)
Emmerton, S.; Muxworthy, A. R.; Sephton, M. A.; Williams, W.
2012-12-01
dominance of multidomain magnetite as well as the appearance of hematite. The presence of hematite only within heavily biodegraded samples suggests a later stage of biodegradation at the surface due to oxidation of magnetite. We have identified a relationship between magnetization and the relative abundance of aliphatic organic compounds in oil. Biodegradation appears to remove both aliphatic hydrocarbons and magnetic susceptibility owing to influence of bacterial metabolic activity that uses ferric iron minerals as electron acceptors reducing the overall magnetic signature. These findings reinforce the importance of bacteria within petroleum systems as well as providing a platform for the use of magnetization as a hydrocarbon migration proxy and as an inexpensive and simple method to determine oil quality.
NASA Astrophysics Data System (ADS)
Yuce, Kutluay; Adelman, Saul J.
2016-07-01
The middle B to the early F main sequence stars are thought to have some of the most quiet atmospheres. In this part of the HR diagram we find stars with atmospheres in radiative equilibrium. They lack the convective circulations of the middle F and cooler stars and the massive stellar winds of hotter stars. Diffusion theory requires the Chemically Peculiar stars to have relatively quiet atmospheres and if there are no magnetic fields they should lack abundance spots. If we look at stars evolving off the Main Sequence in this part of the HR diagram, we see that the evolutionary paths of stars of different mass do not cross. So if we compare stars with the same effective temperature and surface gravity, we are studying stars of the same luminosity and mass. By comparing their elemental abundances, we might be able to identify physical processes which cause their abundances to be different. In this work we begin with stars whose effective temperatures and surface gravities are similar, and which has been analyzed by us using spectra obtained from the Dominion Astrophysical Observatory.
Xi, Beidou; Zhao, Xinyu; He, Xiaosong; Huang, Caihong; Tan, Wenbing; Gao, Rutai; Zhang, Hui; Li, Dan
2016-11-01
Humic-reducing microorganisms (HRMs) could utilize humic substances (HS) as terminal electron mediator to promote the biodegradation of recalcitrant pollutants. However, the dynamics of HRMs during composting has not been explored. Here, high throughput sequencing technology was applied to investigate the patterns of HRMs during three composting systems. A total of 30 main genera of HRMs were identified in three composts, with Proteobacteria being the largest phylum. HRMs were detected with increased diversity and abundance and distinct patterns during composting, which were significantly associated with dissolved organic carbon, dissolved organic nitrogen and germination index. Regulating key physical-chemical parameters is a process control of HRMs community composition, thus promoting the redox capability of the compost. The redox capability of HRMs were strengthened during composting, suggesting that HRMs of the compost may play an important role on pollutant degradation of the compost or when they are applied to the contaminated soils. PMID:27494101
Wilson, Kevin R.; Smith, Jared D.; Kessler, Sean; Kroll, Jesse H.
2011-10-03
The heterogeneous reaction of hydroxyl radicals (OH) with squalane and bis(2-ethylhexyl) sebacate (BES) particles are used as model systems to examine how distributions of reactionproducts evolve during the oxidation of chemically reduced organic aerosol. A kinetic model of multigenerational chemistry, which is compared to previously measured (squalane) and new(BES) experimental data, reveals that it is the statistical mixtures of different generations of oxidation products that control the average particle mass and elemental composition during thereaction. The model suggests that more highly oxidized reaction products, although initially formed with low probability, play a large role in the production of gas phase reaction products.In general, these results highlight the importance of considering atmospheric oxidation as a statistical process, further suggesting that the underlying distribution of molecules could playimportant roles in aerosol formation as well as in the evolution of key physicochemical properties such as volatility and hygroscopicity.
ERIC Educational Resources Information Center
Jones, Thomas A.
1983-01-01
Mathematical techniques used to solve geological problems are briefly discussed (including comments on use of geostatistics). Highlights of conferences/meetings and conference papers in mathematical geology are also provided. (JN)
Mathematics anxiety and mathematics achievement
NASA Astrophysics Data System (ADS)
Sherman, Brian F.; Wither (Post.), David P.
2003-09-01
This paper is a distillation of the major result from the 1998 Ph.D. thesis of the late David Wither. It details a longitudinal study over five years of the relationship between mathematics anxiety and mathematics achievement. It starts from the already well documented negative correlation between the two, and seeks to establish one of the three hypotheses—that mathematics anxiety causes an impairment of mathematics achievement; that lack of mathematics achievement causes mathematics anxiety; or that there is a third underlying cause of the two.
ERIC Educational Resources Information Center
Kilpatrick, Jeremy
2014-01-01
This paper addresses the contested way that ethnomathematics has sometimes been received by mathematicians and others and what that disagreement might suggest about issues in mathematics education; namely, (a) the relation of ethnomathematics to academic mathematics; (b) recent efforts to reform secondary school mathematics so that it prepares…
Schulz, Philipp; Neukermans, Jenny; Van Der Kelen, Katrien; Mühlenbock, Per; Van Breusegem, Frank; Noctor, Graham; Teige, Markus; Metzlaff, Michael; Hannah, Matthew A.
2012-01-01
Poly-ADP-ribose polymerase (PARP) post-translationally modifies proteins through the addition of ADP-ribose polymers, yet its role in modulating plant development and stress responses is only poorly understood. The experiments presented here address some of the gaps in our understanding of its role in stress tolerance and thereby provide new insights into tolerance mechanisms and growth. Using a combination of chemical and genetic approaches, this study characterized phenotypes associated with PARP inhibition at the physiological level. Molecular analyses including gene expression analysis, measurement of primary metabolites and redox metabolites were used to understand the underlying processes. The analysis revealed that PARP inhibition represses anthocyanin and ascorbate accumulation under stress conditions. The reduction in defense is correlated with enhanced biomass production. Even in unstressed conditions protective genes and molecules are repressed by PARP inhibition. The reduced anthocyanin production was shown to be based on the repression of transcription of key regulatory and biosynthesis genes. PARP is a key factor for understanding growth and stress responses of plants. PARP inhibition allows plants to reduce protection such as anthocyanin, ascorbate or Non-Photochemical-Quenching whilst maintaining high energy levels likely enabling the observed enhancement of biomass production under stress, opening interesting perspectives for increasing crop productivity. PMID:22662141
Mathematical Modeling and Pure Mathematics
ERIC Educational Resources Information Center
Usiskin, Zalman
2015-01-01
Common situations, like planning air travel, can become grist for mathematical modeling and can promote the mathematical ideas of variables, formulas, algebraic expressions, functions, and statistics. The purpose of this article is to illustrate how the mathematical modeling that is present in everyday situations can be naturally embedded in…
NASA Astrophysics Data System (ADS)
Tian, Mingwei; Du, Minzhi; Qu, Lijun; Zhang, Kun; Li, Hongliang; Zhu, Shifeng; Liu, Dongdong
2016-09-01
Versatile and ductile conductive carbonized cotton fabrics decorated with reduced graphene oxide (rGO)/manganese dioxide (MnO2) are prepared in this paper. In order to endow multifunction to cotton fabric, graphene oxide (GO) is deposited on cotton fibers by simple dip-coating route. MnO2 nanoparticles are assembled on the surface of cotton fabric through in-situ chemical solution deposition. MnO2/GO@cotton fabrics are carbonized to achieve conductive fabric (MnO2/rGO@C). The morphologies and structures of obtained fabrics are characterized by SEM, XRD, ICP and element analysis, and their electro-properties including electro-chemical, electro-heating and electro-mechanical properties are evaluated. The MnO2/rGO@C yields remarkable specific capacitance of 329.4 mA h/g at the current density of 100 mA/g, which is more than 40% higher than that of the control carbonized cotton fabric (231 mA h/g). Regarding electro-heating properties, the temperature of MnO2/rGO@C fabric could be monotonically increased to the steady-state maximum temperatures (ΔTmax) of 36 °C within 5 min under the applied voltage 15 V while the ΔTmax = 17 °C of the control case. In addition, MnO2/rGO@C exhibits repeatable electro-mechanical properties and its normalized resistance (R-R0)/R0 could reach 0.78 at a constant strain (curvature = 0.6 cm-1). The MnO2/rGO@C fabric is versatile, scalable, and adaptable to a wide variety of smart textiles applications.
NASA Astrophysics Data System (ADS)
Adams, P. J.
2015-12-01
Though essential for informed decision-making, it is challenging to estimate the air quality and public health impacts associated with current and future energy generation scenarios because the analysis must address the complicated atmospheric processes that air pollutants undergo: emissions, dispersion, chemistry, and removal. Employing a chemical transport model (CTM) is the most rigorous way to address these atmospheric processes. However, CTMs are expensive from a computational standpoint and, therefore, beyond the reach of policy analysis for many types of problems. On the other hand, previously available reduced-form models used for policy analysis fall short of the rigor of CTMs and may lead to biased results. To address this gap, we developed the Estimating Air pollution Social Impacts Using Regression (EASIUR) method, which builds parameterizations that predict per-tonne social costs and intake fractions for pollutants emitted from any location in the United States. Derived from a large database of tagged CTM simulations, the EASIUR method predicts social costs almost indistinguishable from a full CTM but with negligible computational requirements. We found that the average mortality-related social costs from inorganic PM2.5 and its precursors in the United States are 150,000-180,000/t EC, 21,000-34,000/t SO2, 4,200-15,000/t NOx, and 29,000-85,000/t NH3. This talk will demonstrate examples of using both CTMs and reduced-form models for assessing air quality impacts associated with current energy production activities as well as a future deployment of carbon capture and sequestration.
Cowley, Elise S.; Kopf, Sebastian H.; LaRiviere, Alejandro
2015-01-01
ABSTRACT Severe and persistent bacterial lung infections characterize cystic fibrosis (CF). While several studies have documented the microbial diversity within CF lung mucus, we know much less about the inorganic chemistry that constrains microbial metabolic processes and their distribution. We hypothesized that sputum is chemically heterogeneous both within and between patients. To test this, we measured microprofiles of oxygen and sulfide concentrations as well as pH and oxidation-reduction potentials in 48 sputum samples from 22 pediatric patients with CF. Inorganic ions were measured in 20 samples from 12 patients. In all cases, oxygen was depleted within the first few millimeters below the sputum-air interface. Apart from this steep oxycline, anoxia dominated the sputum environment. Different sputum samples exhibited a broad range of redox conditions, with either oxidizing (16 mV to 355 mV) or reducing (−300 to −107 mV) potentials. The majority of reduced samples contained hydrogen sulfide and had a low pH (2.9 to 6.5). Sulfide concentrations increased at a rate of 0.30 µM H2S/min. Nitrous oxide was detected in only one sample that also contained sulfide. Microenvironmental variability was observed both within a single patient over time and between patients. Modeling oxygen dynamics within CF mucus plugs indicates that anoxic zones vary as a function of bacterial load and mucus thickness and can occupy a significant portion of the mucus volume. Thus, aerobic respiration accounts only partially for pathogen survival in CF sputum, motivating research to identify mechanisms of survival under conditions that span fluctuating redox states, including sulfidic environments. PMID:26220964
ERIC Educational Resources Information Center
Langbort, Carol, Ed.; Curtis, Deborah, Ed.
2000-01-01
The focus of this special issue is mathematics education. All articles were written by graduates of the new masters Degree program in which students earn a Master of Arts degree in Education with a concentration in Mathematics Education at San Francisco State University. Articles include: (1) "Developing Teacher-Leaders in a Masters Degree Program…
ERIC Educational Resources Information Center
Huckstep, Peter
2002-01-01
Contends teachers must resist the temptation to suggest that, while children can create stories and melodies, they cannot create mathematics. Quotes mathematician G. H. Hardy: "A mathematician, like a painter or poet, is a 'maker' of patterns." Considers mathematics should be able to stand up for itself. (BT)
ERIC Educational Resources Information Center
Flannery, Carol A.
This manuscript provides information and problems for teaching mathematics to vocational education students. Problems reflect applications of mathematical concepts to specific technical areas. The materials are organized into six chapters. Chapter 1 covers basic arithmetic, including fractions, decimals, ratio and proportions, percentages, and…
ERIC Educational Resources Information Center
Prochazka, Helen
2004-01-01
One section of this "scrapbook" section describes Pythagoras' belief in the connections between music and mathematics -- that everything in the universe was a series of harmonies and regulated by music. Another section explains why Phythagoras felt it important for women to be encouraged to learn mathematics. At least 28 women were involved in his…
Rodríguez, Luis; Gómez, Rocío; Sánchez, Virtudes; Alonso-Azcárate, Jacinto
2016-04-01
The goal of this research was to assess the potential of several industrial wastes to immobilise metals in two polluted soils deriving from an old Pb/Zn mine. Two different approaches were used to assess the performance of different amendments: a chemical one, using extraction by ethylenediaminetetraacetic acid (EDTA), and a biological one, using Lupinus albus as a bio-indicator. Four amendments were used: inorganic sugar production waste (named 'sugar foam', SF), sludge from a drinking water treatment sludge (DWS), organic waste from olive mill waste (OMW) and paper mill sludge (PMS). Amendment to soil ratios ranged from 0.1 to 0.3 (w/w). All the amendments were capable of significantly decreasing (p < 0.05) EDTA-extractable Pb, Zn and Cu concentrations in the two soils used, with decreases in ranges 21-100, 25-100 and 2-100 % for Pb, Zn and Cu, respectively. The amendments tested were also effective in reducing the bioavailability of Pb and Zn for L. albus, which gave rise to a decrease in shoot metal accumulation by the lupine plants compared to that found in the control soil. That decrease reached up to 5.6 and 2.8 times for Pb and Zn, respectively, being statistically significant in most cases. Moreover, application of the OMW, DWS and SF amendments led to higher average values of plant biomass (up to 71%) than those obtained in the control soil. The results obtained showed the technology put forward to be a viable means of remediating mine soils as it led to a decrease in the availability and toxicity of metals and, thus, facilitated the growth of a vegetation layer. PMID:25772873
NASA Astrophysics Data System (ADS)
Kartono, R.; Basuki, Y. T.
2014-03-01
The purpose of this paper is to examine the sets of model and literature review to prove that strategy of applying free chemical usage in purified water system for pharmaceutical industry would be help the existing and new pharmaceutical companies to comply with part of Natioanal Agency of Drug and Food Control / Badan Pengawas Obat dan Makanan (NADFC/BPOM) regulation in order to achieve "Cara Pembuatan Obat yang Baik" (CPOB) of Indonesia pharmaceutical industry. One of the main reasons is when we figured out the number of Indonesian pharmaceutical industries in 2012 are kept reducing compare to the increasing numbers of Indonesian population growth. This strategy concept also might help the industries to reducing environmental pollution, and operational cost in pharmaceutical industries, by reducing of the chemical usage for water treatment process in floculation and cougulation and chlorination for sterillization. This new model is free usage of chemicals for purified water generation system process and sterilization. The concept offering of using membrane technology- Reverse Osmosis (RO) membrane base treatment to replace traditional chemical base treatment, following enhance Electrodeionization (EDI) as final polisher for controlling conductivity, and finally Ultra Violet (UV) disinfectant technology as final guard for bacteria controls instead of chemical base system in purified water generation system.
Technology Transfer Automated Retrieval System (TEKTRAN)
Sustainable strategies for control of Sclerotinia sclerotiorum on oilseed rape are needed. Here we tested combinations of Trichoderma sp. Tri-1, formulated with oilseed rape seedcake and straw, with reduced application rates of the chemical pesticide Carbendazim for control of this pathogen on oils...
ERIC Educational Resources Information Center
McCammon, Richard B.
1979-01-01
The year 1978 marked a continued trend toward practical applications in mathematical geology. Developments included work in interactive computer graphics, factor analysis, the vanishing tons problem, universal kriging, and resource estimating. (BB)
ERIC Educational Resources Information Center
Gardner, Martin
1978-01-01
Describes the life and work of Charles Peirce, U.S. mathematician and philosopher. His accomplishments include contributions to logic, the foundations of mathematics and scientific method, and decision theory and probability theory. (MA)
ERIC Educational Resources Information Center
Davis-Van Atta, David, Ed.
This guide, published for the first time, provides prospective college students detailed information on 190 United States colleges and universities identified as having very strong track records in the sciences and mathematics. Following a description of how institutions were identified for inclusion by David Davis-Van Atta, and a discussion on…
ERIC Educational Resources Information Center
Bossé, Michael J.; Adu-Gyamfi, Kwaku; Chandler, Kayla; Lynch-Davis, Kathleen
2016-01-01
Dynamic mathematical environments allow users to reify mathematical concepts through multiple representations, transform mathematical relations and organically explore mathematical properties, investigate integrated mathematics, and develop conceptual understanding. Herein, we integrate Boolean algebra, the functionalities of a dynamic…
Mathematical wit and mathematical cognition.
Aberdein, Andrew
2013-04-01
The published works of scientists often conceal the cognitive processes that led to their results. Scholars of mathematical practice must therefore seek out less obvious sources. This article analyzes a widely circulated mathematical joke, comprising a list of spurious proof types. An account is proposed in terms of argumentation schemes: stereotypical patterns of reasoning, which may be accompanied by critical questions itemizing possible lines of defeat. It is argued that humor is associated with risky forms of inference, which are essential to creative mathematics. The components of the joke are explicated by argumentation schemes devised for application to topic-neutral reasoning. These in turn are classified under seven headings: retroduction, citation, intuition, meta-argument, closure, generalization, and definition. Finally, the wider significance of this account for the cognitive science of mathematics is discussed. PMID:23512504
Glimm, J.
2009-10-14
Progress for the past decade or so has been extraordinary. The solution of Fermat's Last Theorem [11] and of the Poincare Conjecture [1] have resolved two of the most outstanding challenges to mathematics. For both cases, deep and advanced theories and whole subfields of mathematics came into play and were developed further as part of the solutions. And still the future is wide open. Six of the original seven problems from the Clay Foundation challenge remain open, the 23 DARPA challenge problems are open. Entire new branches of mathematics have been developed, including financial mathematics and the connection between geometry and string theory, proposed to solve the problems of quantized gravity. New solutions of the Einstein equations, inspired by shock wave theory, suggest a cosmology model which fits accelerating expansion of the universe possibly eliminating assumptions of 'dark matter'. Intellectual challenges and opportunities for mathematics are greater than ever. The role of mathematics in society continues to grow; with this growth comes new opportunities and some growing pains; each will be analyzed here. We see a broadening of the intellectual and professional opportunities and responsibilities for mathematicians. These trends are also occuring across all of science. The response can be at the level of the professional societies, which can work to deepen their interactions, not only within the mathematical sciences, but also with other scientific societies. At a deeper level, the choices to be made will come from individual mathematicians. Here, of course, the individual choices will be varied, and we argue for respect and support for this diversity of responses. In such a manner, we hope to preserve the best of the present while welcoming the best of the new.
Ding, Hai-Yan; Li, Gai-Ru; Yu, Ying-Ge; Guo, Wei; Zhi, Ling; Li, Xin-Xia
2014-04-01
A method for on-line monitoring the dissolution of Valsartan and hydrochlorothiazide tablets assisted by mathematical separation model of linear equations was established. UV spectrums of valsartan and hydrochlorothiazide were overlapping completely at the maximum absorption wavelength respectively. According to the Beer-Lambert principle of absorbance additivity, the absorptivity of Valsartan and hydrochlorothiazide was determined at the maximum absorption wavelength, and the dissolubility of Valsartan and hydrochlorothiazide tablets was detected by fiber-optic dissolution test (FODT) assisted by the mathematical separation model of linear equations and compared with the HPLC method. Results show that two ingredients were real-time determined simultaneously in given medium. There was no significant difference for FODT compared with HPLC (p > 0.05). Due to the dissolution behavior consistency, the preparation process of different batches was stable and with good uniformity. The dissolution curves of valsartan were faster and higher than hydrochlorothiazide. The dissolutions at 30 min of Valsartan and hydrochlorothiazide were concordant with US Pharmacopoeia. It was concluded that fiber-optic dissolution test system assisted by the mathematical separation model of linear equations that can detect the dissolubility of Valsartan and hydrochlorothiazide simultaneously, and get dissolution profiles and overall data, which can directly reflect the dissolution speed at each time. It can provide the basis for establishing standards of the drug. Compared to HPLC method with one-point data, there are obvious advantages to evaluate and analyze quality of sampling drug by FODT. PMID:25007628
St.Martin, E.J.
1995-08-01
A novel biological/chemical process for converting cyclohexane into caprolactam was investigated. Microorganisms in a bioreactor would be used to convert cyclohexane into caprolactone followed by chemical synthesis of caprolactam using ammonia. The proposed bioprocess would be more energy efficient and reduce byproducts and wastes that are generated by the current chemical process. We have been successful in isolating from natural soil and water samples two microorganisms that can utilize cyclohexane as a sole source of carbon and energy for growth. These microorganisms were shown to have the correct metabolic intermediates and enzymes to convert cyclohexane into cyclohexanol, cyclohexanone and caprolactone. Genetic techniques to create and select for caprolactone hydrolase negative-mutants are being developed. These blocked-mutants will be used to convert cyclohexane into caprolactone but, because of the block, be unable to metabolize the caprolactone further and excrete it as a final end product.
NASA Astrophysics Data System (ADS)
Özcan, Umut; Yilmaz, Erkan; Özcan, Lale; Furuhashi, Masato; Vaillancourt, Eric; Smith, Ross O.; Görgün, Cem Z.; Hotamisligil, Gökhan S.
2006-08-01
Endoplasmic reticulum (ER) stress is a key link between obesity, insulin resistance, and type 2 diabetes. Here, we provide evidence that this mechanistic link can be exploited for therapeutic purposes with orally active chemical chaperones. 4-Phenyl butyric acid and taurine-conjugated ursodeoxycholic acid alleviated ER stress in cells and whole animals. Treatment of obese and diabetic mice with these compounds resulted in normalization of hyperglycemia, restoration of systemic insulin sensitivity, resolution of fatty liver disease, and enhancement of insulin action in liver, muscle, and adipose tissues. Our results demonstrate that chemical chaperones enhance the adaptive capacity of the ER and act as potent antidiabetic modalities with potential application in the treatment of type 2 diabetes.
NASA Astrophysics Data System (ADS)
Egeland, G. W.; Mariani, R. D.; Hartmann, T.; Porter, D. L.; Hayes, S. L.; Kennedy, J. R.
2013-01-01
Fast-reactor fuel alloys produce lanthanide fission products which migrate to the fuel/cladding interface causing fuel-cladding chemical interaction. To test viability of pinning these lanthanides, neodymium was selected as an iron interacting lanthanide and palladium was chosen as the dopant. An arc-melt produced 1:1 neodymium-palladium compound and pure neodymium were tested against iron in diffusion couples at temperatures above and below the Nd-Fe eutectic melting point.
Lee, Eun Sang; Lee, Hae-June; Lee, Yoon-Jin; Jeong, Jae-Hoon; Kang, Seongman; Lim, Young-Bin
2014-07-25
Highlights: • UPR activation precedes caspase activation in irradiated IEC-6 cells. • Chemical ER stress inducers radiosensitize IEC-6 cells. • siRNAs that targeted ER stress responses ameliorate IR-induced cell death. • Chemical chaperons prevent cell death in irradiated IEC-6 cells. - Abstract: Radiotherapy, which is one of the most effective approaches to the treatment of various cancers, plays an important role in malignant cell eradication in the pelvic area and abdomen. However, it also generates some degree of intestinal injury. Apoptosis in the intestinal epithelium is the primary pathological factor that initiates radiation-induced intestinal injury, but the mechanism by which ionizing radiation (IR) induces apoptosis in the intestinal epithelium is not clearly understood. Recently, IR has been shown to induce endoplasmic reticulum (ER) stress, thereby activating the unfolded protein response (UPR) signaling pathway in intestinal epithelial cells. However, the consequences of the IR-induced activation of the UPR signaling pathway on radiosensitivity in intestinal epithelial cells remain to be determined. In this study, we investigated the role of ER stress responses in IR-induced intestinal epithelial cell death. We show that chemical ER stress inducers, such as tunicamycin or thapsigargin, enhanced IR-induced caspase 3 activation and DNA fragmentation in intestinal epithelial cells. Knockdown of Xbp1 or Atf6 with small interfering RNA inhibited IR-induced caspase 3 activation. Treatment with chemical chaperones prevented ER stress and subsequent apoptosis in IR-exposed intestinal epithelial cells. Our results suggest a pro-apoptotic role of ER stress in IR-exposed intestinal epithelial cells. Furthermore, inhibiting ER stress may be an effective strategy to prevent IR-induced intestinal injury.
Tucker, Mark D.
2011-09-20
A reduced weight decontamination formulation that utilizes a solid peracid compound (sodium borate peracetate) and a cationic surfactant (dodecyltrimethylammonium chloride) that can be packaged with all water removed. This reduces the packaged weight of the decontamination formulation by .about.80% (as compared to the "all-liquid" DF-200 formulation) and significantly lowers the logistics burden on the warfighter. Water (freshwater or saltwater) is added to the new decontamination formulation at the time of use from a local source.
Cassidy, Daniel P; Srivastava, Vipul J; Dombrowski, Frank J; Lingle, James W
2015-10-30
Laboratory batch reactors were maintained for 32 weeks to test the potential for an in situ remedy that combines chemical oxidation, stabilization, and anaerobic bioremediation in a single application to treat soil from a manufactured gas plant, contaminated with polycyclic aromatic hydrocarbons (PAH) and benzene, toluene, ethylbenzene, and xylenes (BTEX). Portland cement and slaked lime were used to activate the persulfate and to stabilize/encapsulate the contaminants that were not chemically oxidized. Native sulfate-reducing bacteria degraded residual contaminants using the sulfate left after persulfate activation. The ability of the combined remedy to reduce contaminant mass and leachability was compared with NaOH-activated persulfate, stabilization, and sulfate-reducing bioremediation as stand-alone technologies. The stabilization amendments increased pH and temperature sufficiently to activate the persulfate within 1 week. Activation with both stabilization amendments and NaOH removed between 55% and 70% of PAH and BTEX. However, combined persulfate and stabilization significantly reduced the leachability of residual BTEX and PAH compared with NaOH activation. Sulfide, 2-naphthoic acid, and the abundance of subunit A of the dissimilatory sulfite reductase gene (dsrA) were used to monitor native sulfate-reducing bacteria, which were negatively impacted by activated persulfate, but recovered completely within weeks.
Cassidy, Daniel P; Srivastava, Vipul J; Dombrowski, Frank J; Lingle, James W
2015-10-30
Laboratory batch reactors were maintained for 32 weeks to test the potential for an in situ remedy that combines chemical oxidation, stabilization, and anaerobic bioremediation in a single application to treat soil from a manufactured gas plant, contaminated with polycyclic aromatic hydrocarbons (PAH) and benzene, toluene, ethylbenzene, and xylenes (BTEX). Portland cement and slaked lime were used to activate the persulfate and to stabilize/encapsulate the contaminants that were not chemically oxidized. Native sulfate-reducing bacteria degraded residual contaminants using the sulfate left after persulfate activation. The ability of the combined remedy to reduce contaminant mass and leachability was compared with NaOH-activated persulfate, stabilization, and sulfate-reducing bioremediation as stand-alone technologies. The stabilization amendments increased pH and temperature sufficiently to activate the persulfate within 1 week. Activation with both stabilization amendments and NaOH removed between 55% and 70% of PAH and BTEX. However, combined persulfate and stabilization significantly reduced the leachability of residual BTEX and PAH compared with NaOH activation. Sulfide, 2-naphthoic acid, and the abundance of subunit A of the dissimilatory sulfite reductase gene (dsrA) were used to monitor native sulfate-reducing bacteria, which were negatively impacted by activated persulfate, but recovered completely within weeks. PMID:26093352
ERIC Educational Resources Information Center
Rogness, Jonathan
2011-01-01
Advances in computer graphics have provided mathematicians with the ability to create stunning visualizations, both to gain insight and to help demonstrate the beauty of mathematics to others. As educators these tools can be particularly important as we search for ways to work with students raised with constant visual stimulation, from video games…
ERIC Educational Resources Information Center
Hadlock, Charles R
2013-01-01
The movement of groundwater in underground aquifers is an ideal physical example of many important themes in mathematical modeling, ranging from general principles (like Occam's Razor) to specific techniques (such as geometry, linear equations, and the calculus). This article gives a self-contained introduction to groundwater modeling with…
ERIC Educational Resources Information Center
Catterton, Gene; And Others
This material was developed to be used with the non college-bound student in the senior high school. It provides the student with everyday problems and experiences in which practical mathematical applications are made. The package includes worksheets pertaining to letterhead invoices, sales slips, payroll sheets, inventory sheets, carpentry and…
Warby, Richard A F; Johnson, Chris E; Driscoll, Charles T
2005-09-01
Changes in lake water chemistry between 1984 and 2001 at 130 stratified random sites across the northeastern United States were studied to evaluate the population-level effects of decreases in acidic deposition. Surface-water S04(2-) concentrations decreased across the region at a median rate of -1.53 microequiv L(-1) year(-1). Calcium concentrations also decreased, with a median rate of -1.73 microequiv L(-1) year(-1). This decrease in Ca2+ retarded the recovery of surface water acid neutralizing capacity (Gran ANC), which increased at a median rate of 0.66 microequiv L(-1) year(-1). There were small increases in pH in all subregions except central New England and Maine, where the changes were not statistically significant. Median NO3- trends were not significant except in the Adirondacks, where NO3- concentrations increased at a rate of 0.53 microequiv L(-1) year(-1). A regionwide decrease in the concentration of total Al, especially in ponds with low ANC values (ANC < 25 microequiv L(-1)), was observed in the Adirondack subregion. These changes in Al were consistent with the general pattern of increasing pH and ANC. Despite the general pattern of chemical recovery, many ponds remain chronically acidic or are susceptible to episodic acidification. The continued chemical and biological recovery at sites in the northeastern United States will depend on further controls on S and N emissions.
Chen, Yaqin; Wu, Zhihong; Zhao, Shuiping; Xiang, Rong
2016-01-01
Obesity, which is characteristic by chronic inflammation, is defined as abnormal or excessive fat accumulation in adipose tissues. Endoplasmic reticulum (ER) stress is increased in adipose tissue of obese state and is known to be strongly associated with chronic inflammation. The aim of this study was to investigate the effect of ER stress on adipokine secretion in obese mice and explore the potential mechanisms. In this study, we found high-fat diet induced-obesity contributed to strengthened ER stress and triggered chronic inflammation in adipose tissue. Chemical chaperones, 4-PBA and TUDCA, modified metabolic disorders and decreased the levels of inflammatory cytokines in obese mice fed a high-fat diet. The alleviation of ER stress is in accordance with the decrease of free cholesterol in adipose tissue. Furthermore chemical chaperones suppress NF-κB activity in adipose tissue of obese mice in vivo. In vitro studies showed IKK/NF-κB may be involved in the signal transduction of adipokine secretion dysfunction induced by ER stress. The present study revealed the possibility that inhibition of ER stress may be a novel drug target for metabolic abnormalities associated with obesity. Further studies are now needed to characterize the initial incentive of sustained ER stress in obese. PMID:27271106
NASA Astrophysics Data System (ADS)
Paesano, Andrea; Silva, Alexandre Christófaro; Ivashita, Flávio Francisco; Cerqueira Machado-Flavio Sives, Carla Fabiana; Sives, Flávio; Mercader, Roberto Carlos; Fabris, José Domingos
2014-04-01
A peatland in Pinheiro, Diamantina City, Minas Gerais State - Brazil, was sampled at different depths of two profiles with diverse vegetation coverings (grassland field and bush) in order to collect materials that might reflect changes in the chemical states of iron over the peat formation coming from original minerals such as hematitic phyllite surrounding the boggy pedon. Samples collected were chemically, structurally and magnetically characterized. The results show that both series of peats are composed of organic matter and minerals such as quartz, kaolinite, gibbsite, rutile and muscovite. Deeper layers present only quartz. Mössbauer spectroscopy shows that iron is present in both electron states, Fe2+ and Fe3+, under both vegetations, each valence appearing in the spectra in the form of a discrete doublet. No hyperfine magnetic splitting was observed in any spectrum at room temperature. The Mössbauer subspectral area of Fe2+ tended to increase from the upper to deeper layers. Magnetic measurements reveal that the magnetic response of the surface samples is the highest, displaying a sharp decrease below 15 cm and that the magnetic signal is a superposition of (super)paramagnetic and ferrimagnetic contributions. Samples from the grassland field also show a diamagnetic component for the deeper layers.
Kage, Hirokazu; Riva, Elena; Parascandolo, James S; Kreutzer, Martin F; Tosin, Manuela; Nett, Markus
2015-12-21
Synthetic chain terminators were used to capture the biosynthetic intermediates from a partially reducing iterative type I polyketide synthase, which is integrated into a multimodular biosynthesis enzyme. The off-loaded metabolites clarified the timing of ketoreduction and aromatization in the assembly of the antibiotic micacocidin. PMID:26507693
Technology Transfer Automated Retrieval System (TEKTRAN)
Improving soil fertility/productivity and reducing environmental impact of nitrogen (N) fertilization in intensive farming systems are essential for sustainable agriculture and food security around the world. The objective of this study was to determine the long-term effects of various fertilization...
Chmelík, M; Kukurová, I Just; Gruber, S; Krššák, M; Valkovič, L; Trattnig, S; Bogner, W
2013-05-01
A fully adiabatic phosphorus (31P) two-dimensional (2D) chemical shift spectroscopic imaging sequence with reduced chemical shift displacement error for 7 T, based on 1D-image-selected in vivo spectroscopy, combined with 2D-chemical shift spectroscopic imaging selection, was developed. Slice-selective excitation was achieved by a spatially selective broadband GOIA-W(16,4) inversion pulse with an interleaved subtraction scheme before nonselective adiabatic excitation, and followed by 2D phase encoding. The use of GOIA-W(16,4) pulses (bandwidth 4.3-21.6 kHz for 10-50 mm slices) reduced the chemical shift displacement error in the slice direction ∼1.5-7.7 fold, compared to conventional 2D-chemical shift spectroscopic imaging with Sinc3 selective pulses (2.8 kHz). This reduction was experimentally demonstrated with measurements of an MR spectroscopy localization phantom and with experimental evaluation of pulse profiles. In vivo experiments in clinically acceptable measurement times were demonstrated in the calf muscle (nominal voxel volume, 5.65 ml in 6 min 53 s), brain (10 ml, 6 min 32 s), and liver (8.33 ml, 8 min 14 s) of healthy volunteers at 7 T. High reproducibility was found in the calf muscle at 7 T. In combination with adiabatic excitation, this sequence is insensitive to the B1 inhomogeneities associated with surface coils. This sequence, which is termed GOIA-1D-ISIS/2D-CSI (goISICS), has the potential to be applied in both clinical research and in the clinical routine.
Mathematics Curriculum Guide. Mathematics IV.
ERIC Educational Resources Information Center
Gary City Public School System, IN.
GRADES OR AGES: Grade 12. SUBJECT MATTER: Mathematics. ORGANIZATION AND PHYSICAL APPEARANCE: The subject matter is presented in four columns: major areas, significant outcomes, observations and suggestions, and films and references. The topics include: sets-relations-functions, circular functions, graphs of circular functions, inverses of circular…
Richard A.F. Warby; Chris E. Johnson; Charles T. Driscoll
2005-09-01
Changes in lake water chemistry between 1984 and 2001 at 130 stratified random sites across the northeastern United States were studied to evaluate the population-level effects of decreases in acidic deposition. Surface-water SO{sub 4}{sup 2-} concentrations decreased across the region at a median rate of -1.53 {mu}equiv L{sup -1} year{sup -1}. Calcium concentrations also decreased, with a median rate of -1.73 {mu}equiv L{sup -1} year{sup -1}. This decrease in Ca{sub 2+} retarded the recovery of surface water acid neutralizing capacity (Gran ANC), which increased at a median rate of 0.66 {mu}equiv L{sup -1} year{sup -1}. There were small increases in pH in all subregions except central New England and Maine, where the changes were not statistically significant. Median NO{sub 3}{sup -} trends were not significant except in the Adirondacks, where NO{sub 3}{sup -} concentrations increased at a rate of 0.53 equiv L{sup -1} year{sup -1}. A regionwide decrease in the concentration of total Al, especially in ponds with low ANC values (ANC {lt} 25 {mu}equiv L{sup -1}), was observed in the Adirondack subregion. These changes in Al were consistent with the general pattern of increasing pH and ANC. Despite the general pattern of chemical recovery, many ponds remain chronically acidic or are susceptible to episodic acidification. The continued chemical and biological recovery at sites in the northeastern United States will depend on further controls on S and N emissions. 27 refs., 4 figs., 3 tabs.
Bramsen, Jesper B.; Pakula, Malgorzata M.; Hansen, Thomas B.; Bus, Claus; Langkjær, Niels; Odadzic, Dalibor; Smicius, Romualdas; Wengel, Suzy L.; Chattopadhyaya, Jyoti; Engels, Joachim W.; Herdewijn, Piet; Wengel, Jesper; Kjems, Jørgen
2010-01-01
Small interfering RNAs (siRNAs) are now established as the preferred tool to inhibit gene function in mammalian cells yet trigger unintended gene silencing due to their inherent miRNA-like behavior. Such off-target effects are primarily mediated by the sequence-specific interaction between the siRNA seed regions (position 2–8 of either siRNA strand counting from the 5′-end) and complementary sequences in the 3′UTR of (off-) targets. It was previously shown that chemical modification of siRNAs can reduce off-targeting but only very few modifications have been tested leaving more to be identified. Here we developed a luciferase reporter-based assay suitable to monitor siRNA off-targeting in a high throughput manner using stable cell lines. We investigated the impact of chemically modifying single nucleotide positions within the siRNA seed on siRNA function and off-targeting using 10 different types of chemical modifications, three different target sequences and three siRNA concentrations. We found several differently modified siRNAs to exercise reduced off-targeting yet incorporation of the strongly destabilizing unlocked nucleic acid (UNA) modification into position 7 of the siRNA most potently reduced off-targeting for all tested sequences. Notably, such position-specific destabilization of siRNA–target interactions did not significantly reduce siRNA potency and is therefore well suited for future siRNA designs especially for applications in vivo where siRNA concentrations, expectedly, will be low. PMID:20453030
Doronin, Konstantin; Shashkova, Elena V.; May, Shannon M.; Hofherr, Sean E.
2009-01-01
Abstract Oncolytic adenoviruses are anticancer agents that replicate within tumors and spread to uninfected tumor cells, amplifying the anticancer effect of initial transduction. We tested whether coating the viral particle with polyethylene glycol (PEG) could reduce transduction of hepatocytes and hepatotoxicity after systemic (intravenous) administration of oncolytic adenovirus serotype 5 (Ad5). Conjugating Ad5 with high molecular weight 20-kDa PEG but not with 5-kDa PEG reduced hepatocyte transduction and hepatotoxicity after intravenous injection. PEGylation with 20-kDa PEG was as efficient at detargeting adenovirus from Kupffer cells and hepatocytes as virus predosing and warfarin. Bioluminescence imaging of virus distribution in two xenograft tumor models in nude mice demonstrated that PEGylation with 20-kDa PEG reduced liver infection 19- to 90-fold. Tumor transduction levels were similar for vectors PEGylated with 20-kDa PEG and unPEGylated vectors. Anticancer efficacy after a single intravenous injection was retained at the level of unmodified vector in large established prostate carcinoma xenografts, resulting in complete elimination of tumors in all animals and long-term tumor-free survival. Anticancer efficacy after a single intravenous injection was increased in large established hepatocellular carcinoma xenografts, resulting in significant prolongation of survival as compared with unmodified vector. The increase in efficacy was comparable to that obtained with predosing and warfarin pretreatment, significantly extending the median of survival. Shielding adenovirus with 20-kDa PEG may be a useful approach to improve the therapeutic window of oncolytic adenovirus after systemic delivery to primary and metastatic tumor sites. PMID:19469693
Doronin, Konstantin; Shashkova, Elena V; May, Shannon M; Hofherr, Sean E; Barry, Michael A
2009-09-01
Oncolytic adenoviruses are anticancer agents that replicate within tumors and spread to uninfected tumor cells, amplifying the anticancer effect of initial transduction. We tested whether coating the viral particle with polyethylene glycol (PEG) could reduce transduction of hepatocytes and hepatotoxicity after systemic (intravenous) administration of oncolytic adenovirus serotype 5 (Ad5). Conjugating Ad5 with high molecular weight 20-kDa PEG but not with 5-kDa PEG reduced hepatocyte transduction and hepatotoxicity after intravenous injection. PEGylation with 20-kDa PEG was as efficient at detargeting adenovirus from Kupffer cells and hepatocytes as virus predosing and warfarin. Bioluminescence imaging of virus distribution in two xenograft tumor models in nude mice demonstrated that PEGylation with 20-kDa PEG reduced liver infection 19- to 90-fold. Tumor transduction levels were similar for vectors PEGylated with 20-kDa PEG and unPEGylated vectors. Anticancer efficacy after a single intravenous injection was retained at the level of unmodified vector in large established prostate carcinoma xenografts, resulting in complete elimination of tumors in all animals and long-term tumor-free survival. Anticancer efficacy after a single intravenous injection was increased in large established hepatocellular carcinoma xenografts, resulting in significant prolongation of survival as compared with unmodified vector. The increase in efficacy was comparable to that obtained with predosing and warfarin pretreatment, significantly extending the median of survival. Shielding adenovirus with 20-kDa PEG may be a useful approach to improve the therapeutic window of oncolytic adenovirus after systemic delivery to primary and metastatic tumor sites.
de Farias Silva, Carlos Eduardo; da Silva Gonçalves, Andreza Heloiza; de Souza Abud, Ana Karla
2016-01-01
Various agricultural residues have been tested as biosorbents due to their low cost, high surface area, and favorable surface chemistry. In this work, a sweet orange albedo was tested as a biosorbent for treatment of real textile effluents. The orange albedo powder was prepared by drying the residue at 50 °C and milling to 30 mesh, and then used for dye adsorption from a alkaline (pH = 10.71) effluent. The adsorption process was studied in batch experiments at 30 °C by measuring color removal and chemical oxygen demand (COD). The color removal was found not to be significantly altered when the effluent was used in its raw state, while COD increased probably due to albedo degradation. For the effluent diluted to 60% (Veffluent VH2O(-1)), color and COD removal percentages of approximately 89% were obtained. It was found that pH played a very significant role on the adsorption process, as the treated albedo displayed a relative pHPZC* of 4.61, and the highest dye removal efficiencies were reached at pH lower than 2. The COD was strongly influenced by the effluent dilution. The effectiveness in eliminating color and COD shows that orange albedo can be potentially used as a biosorbent to treat textile wastewater. PMID:27533873
de Farias Silva, Carlos Eduardo; da Silva Gonçalves, Andreza Heloiza; de Souza Abud, Ana Karla
2016-01-01
Various agricultural residues have been tested as biosorbents due to their low cost, high surface area, and favorable surface chemistry. In this work, a sweet orange albedo was tested as a biosorbent for treatment of real textile effluents. The orange albedo powder was prepared by drying the residue at 50 °C and milling to 30 mesh, and then used for dye adsorption from a alkaline (pH = 10.71) effluent. The adsorption process was studied in batch experiments at 30 °C by measuring color removal and chemical oxygen demand (COD). The color removal was found not to be significantly altered when the effluent was used in its raw state, while COD increased probably due to albedo degradation. For the effluent diluted to 60% (Veffluent VH2O(-1)), color and COD removal percentages of approximately 89% were obtained. It was found that pH played a very significant role on the adsorption process, as the treated albedo displayed a relative pHPZC* of 4.61, and the highest dye removal efficiencies were reached at pH lower than 2. The COD was strongly influenced by the effluent dilution. The effectiveness in eliminating color and COD shows that orange albedo can be potentially used as a biosorbent to treat textile wastewater.
NASA Astrophysics Data System (ADS)
Nurbaity, A.; Sofyan, E. T.; Hamdani, J. S.
2016-08-01
The use of high chemical fertilizer rates in potato production has been applied on the farm in Indonesia. Application of biofertilizer consists of arbuscular mycorrhizal fungi has been tested to reduce the use of NPK rates in production of potato and to determine whether different soil types will have different response to this biofertilizer. A greenhouse experiment was conducted using mixtures of spores of Glomus sp. and inoculant of mycorrhizal helper bacteria Pseudomonas diminuta, applied at different rates of NPK fertilizer (0, 25, 50, 75 and 100% of recommended rates) and different soil types (Andisols and Inceptisols). Results of experiment showed that application of Glomus sp. and P. diminuta reduced the use of NPK up to 50%, where the growth (plant height and tuber number), N,P,K uptake and tuber yields of potato had similar effect to the highest recommendation rate of NPK fertilizer. Inceptisols in general had better response to the biofertiliser compared to Andisols. Findings from this experiment confirmed the evidences that biofertilizer could reduce the use of chemical fertilizer, and the widely distributed soil in Indonesia such as Inceptisols, is potential to be used as a medium for potato production.
Dilemma in Teaching Mathematics
ERIC Educational Resources Information Center
Md Kamaruddin, Nafisah Kamariah; Md Amin, Zulkarnain
2012-01-01
The challenge in mathematics education is finding the best way to teach mathematics. When students learn the reasoning and proving in mathematics, they will be proficient in mathematics. Students must know mathematics before they can apply it. Symbolism and logic is the key to both the learning of mathematics and its effective application to…
NASA Astrophysics Data System (ADS)
Hartmann, Jens; West, A. Joshua; Renforth, Phil; KöHler, Peter; de La Rocha, Christina L.; Wolf-Gladrow, Dieter A.; Dürr, Hans H.; Scheffran, Jürgen
2013-04-01
weathering is an integral part of both the rock and carbon cycles and is being affected by changes in land use, particularly as a result of agricultural practices such as tilling, mineral fertilization, or liming to adjust soil pH. These human activities have already altered the terrestrial chemical cycles and land-ocean flux of major elements, although the extent remains difficult to quantify. When deployed on a grand scale, Enhanced Weathering (a form of mineral fertilization), the application of finely ground minerals over the land surface, could be used to remove CO2 from the atmosphere. The release of cations during the dissolution of such silicate minerals would convert dissolved CO2 to bicarbonate, increasing the alkalinity and pH of natural waters. Some products of mineral dissolution would precipitate in soils or be taken up by ecosystems, but a significant portion would be transported to the coastal zone and the open ocean, where the increase in alkalinity would partially counteract "ocean acidification" associated with the current marked increase in atmospheric CO2. Other elements released during this mineral dissolution, like Si, P, or K, could stimulate biological productivity, further helping to remove CO2 from the atmosphere. On land, the terrestrial carbon pool would likely increase in response to Enhanced Weathering in areas where ecosystem growth rates are currently limited by one of the nutrients that would be released during mineral dissolution. In the ocean, the biological carbon pumps (which export organic matter and CaCO3 to the deep ocean) may be altered by the resulting influx of nutrients and alkalinity to the ocean. This review merges current interdisciplinary knowledge about Enhanced Weathering, the processes involved, and the applicability as well as some of the consequences and risks of applying the method.
NASA Astrophysics Data System (ADS)
Chen, De-Jun; Zhang, Qian-Li; Feng, Jin-Xia; Ju, Ke-Jian; Wang, Ai-Jun; Wei, Jie; Feng, Jiu-Ju
2015-08-01
In this work, a simple, rapid and facile one-pot wet-chemical co-reduction method is developed for synthesis of bimetallic Au-Pt alloyed nanochains supported on reduced graphene oxide (Au-Pt NCs/RGO), in which caffeine is acted as a capping agent and a structure-directing agent, while no any seed, template, surfactant or polymer involved. The as-prepared nanocomposites display enlarged electrochemical active surface area, significantly enhanced catalytic activity and better stability for methanol and ethylene glycol oxidation, compared with commercial Pt-C (Pt 50 wt%), PtRu-C (Pt 30 wt% and Ru 15 wt%) and Pt black.
Teaching Mathematical Modeling in Mathematics Education
ERIC Educational Resources Information Center
Saxena, Ritu; Shrivastava, Keerty; Bhardwaj, Ramakant
2016-01-01
Mathematics is not only a subject but it is also a language consisting of many different symbols and relations. Taught as a compulsory subject up the 10th class, students are then able to choose whether or not to study mathematics as a main subject. The present paper discusses mathematical modeling in mathematics education. The article provides…
Teacher Education and Mathematics: Program Development and Evaluation.
ERIC Educational Resources Information Center
Chapline, Elaine B.
The Teacher Education and Mathematics (TEAM) Program has been developed to reduce mathematics anxiety and increase mathematics confidence and competence of teacher education students; to increase their perception of mathematics as female domain; and to develop their skills in identifying sex bias in curriculum materials and classroom practices.…
Mathematical Modeling of Diverse Phenomena
NASA Technical Reports Server (NTRS)
Howard, J. C.
1979-01-01
Tensor calculus is applied to the formulation of mathematical models of diverse phenomena. Aeronautics, fluid dynamics, and cosmology are among the areas of application. The feasibility of combining tensor methods and computer capability to formulate problems is demonstrated. The techniques described are an attempt to simplify the formulation of mathematical models by reducing the modeling process to a series of routine operations, which can be performed either manually or by computer.
Computer program determines chemical composition of physical system at equilibrium
NASA Technical Reports Server (NTRS)
Kwong, S. S.
1966-01-01
FORTRAN 4 digital computer program calculates equilibrium composition of complex, multiphase chemical systems. This is a free energy minimization method with solution of the problem reduced to mathematical operations, without concern for the chemistry involved. Also certain thermodynamic properties are determined as byproducts of the main calculations.
Edwards, A W F
2011-03-01
Ernst Mayr called the first part of the evolutionary synthesis the 'Fisherian synthesis' on account of the dominant role played by R.A. Fisher in forging a mathematical theory of natural selection together with J.B.S. Haldane and Sewall Wright in the decade 1922-1932. It is here argued that Fisher's contribution relied on a close reading of Darwin's work to a much greater extent than did the contributions of Haldane and Wright, that it was synthetic in contrast to their analytic approach and that it was greatly influenced by his friendship with the Darwin family, particularly with Charles's son Leonard. PMID:21423339
Mathematical Notation in Bibliographic Databases.
ERIC Educational Resources Information Center
Pasterczyk, Catherine E.
1990-01-01
Discusses ways in which using mathematical symbols to search online bibliographic databases in scientific and technical areas can improve search results. The representations used for Greek letters, relations, binary operators, arrows, and miscellaneous special symbols in the MathSci, Inspec, Compendex, and Chemical Abstracts databases are…
Throckmorton, Kurt; Wiemann, Philipp; Keller, Nancy P
2015-09-01
Fungal polyketides are a diverse class of natural products, or secondary metabolites (SMs), with a wide range of bioactivities often associated with toxicity. Here, we focus on a group of non-reducing polyketide synthases (NR-PKSs) in the fungal phylum Ascomycota that lack a thioesterase domain for product release, group V. Although widespread in ascomycete taxa, this group of NR-PKSs is notably absent in the mycotoxigenic genus Fusarium and, surprisingly, found in genera not known for their secondary metabolite production (e.g., the mycorrhizal genus Oidiodendron, the powdery mildew genus Blumeria, and the causative agent of white-nose syndrome in bats, Pseudogymnoascus destructans). This group of NR-PKSs, in association with the other enzymes encoded by their gene clusters, produces a variety of different chemical classes including naphthacenediones, anthraquinones, benzophenones, grisandienes, and diphenyl ethers. We discuss the modification of and transitions between these chemical classes, the requisite enzymes, and the evolution of the SM gene clusters that encode them. Integrating this information, we predict the likely products of related but uncharacterized SM clusters, and we speculate upon the utility of these classes of SMs as virulence factors or chemical defenses to various plant, animal, and insect pathogens, as well as mutualistic fungi. PMID:26378577
Throckmorton, Kurt; Wiemann, Philipp; Keller, Nancy P.
2015-01-01
Fungal polyketides are a diverse class of natural products, or secondary metabolites (SMs), with a wide range of bioactivities often associated with toxicity. Here, we focus on a group of non-reducing polyketide synthases (NR-PKSs) in the fungal phylum Ascomycota that lack a thioesterase domain for product release, group V. Although widespread in ascomycete taxa, this group of NR-PKSs is notably absent in the mycotoxigenic genus Fusarium and, surprisingly, found in genera not known for their secondary metabolite production (e.g., the mycorrhizal genus Oidiodendron, the powdery mildew genus Blumeria, and the causative agent of white-nose syndrome in bats, Pseudogymnoascus destructans). This group of NR-PKSs, in association with the other enzymes encoded by their gene clusters, produces a variety of different chemical classes including naphthacenediones, anthraquinones, benzophenones, grisandienes, and diphenyl ethers. We discuss the modification of and transitions between these chemical classes, the requisite enzymes, and the evolution of the SM gene clusters that encode them. Integrating this information, we predict the likely products of related but uncharacterized SM clusters, and we speculate upon the utility of these classes of SMs as virulence factors or chemical defenses to various plant, animal, and insect pathogens, as well as mutualistic fungi. PMID:26378577
Vengatesan, M R; Shen, Tian-Zi; Alagar, M; Song, Jang-Kun
2016-01-01
We report a cost effective and easy chemical reduction method for exfoliated individual graphene oxide (GO) and GO paper using p-toluene sulfonic acid (PTSA) under mild conditions. Raman spectroscopy, Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), X-ray photon spectroscopy (XPS), thermo gravimetric analysis (TGA) and transmission electron microscopy (TEM) analysis were performed to investigate the quality of GO reduction. Data resulting from the spectral analysis suggest that the reduction method using PTSA is an efficient method to remove oxygen functionalities in the GO and also as an alternative to commonly used reducing agents. We also fabricated chemically reduced GO (RGO) film from GO film using this method. The RGO film exhibits an electrical conductivity of about 10587 Sm⁻¹. These results suggest that this method is very useful for the reduction of GO and GO film or paper using PTSA in a solution process for flexible electronics due to its facile, efficient and cost-effective features. PMID:27398462
NASA Astrophysics Data System (ADS)
Schwerdtfeger, Christine Ann
An N-particle system can be described without approximation using a two-particle reduced density matrix (2-RDM) if the particles are indistinguishable and interact pairwise. If a 2-RDM is determined without using an N-particle wavefunction, the computational advantage of using a two-particle representation is realized. Directly minimizing the energy as a functional of the 2-RDM, however, does not yield a 2-RDM that describes an N -particle system (N-representable). In this thesis we discuss two approaches for determining approximately N-representable 2-RDMS without using wavefunctions. In the first approach, known as the variational 2-RDM method, we minimize the energy as a function of the 2-RDM while explicitly enforcing a subset of N-representability conditions on the 2-RDM to obtain a lower bound to the exact energy. We apply this approach to the strongly correlated quantum phase transition in the 1D transverse Ising model and demonstrate that compared to the exact solution, the variational 2-RDM method provides an accurate description of the Ising lattice and is an alternative tool for locating a quantum phase transition using only the ground electronic state. The second approach used in this work is the parametric 2-RDM method. The 2-RDM is parameterized using a reference 2-RDM and a subset of N-representability conditions. We apply the method to several isomerization reactions including those of oxywater, ammonia oxide, carbonic acid and diazene. Results obtained using the parametric 2-RDM method reproduce experimental results in predicting the equilibrium ratio of cis- to trans-carbonic acid isomers and describe the multireference transition state in the isomerization of diazene as well as multireference wavefunction methods. We extend the 2-RDM parameterization to describe electronic systems in arbitrary spin states and demonstrate similar accuracy at equilibrium and nonequilibrium geometries as was seen in describing singlet electronic states. Lastly, we
Authenticity of Mathematical Modeling
ERIC Educational Resources Information Center
Tran, Dung; Dougherty, Barbara J.
2014-01-01
Some students leave high school never quite sure of the relevancy of the mathematics they have learned. They fail to see links between school mathematics and the mathematics of everyday life that requires thoughtful decision making and often complex problem solving. Is it possible to bridge the gap between school mathematics and the mathematics in…
Rice, Antonie; Liu, Yanbin; Michaelis, Mary Lou; Himes, Richard H; Georg, Gunda I; Audus, Kenneth L
2005-02-10
The purpose of this work was to introduce a chemical modification into the paclitaxel (Taxol) structure to reduce interactions with the product of the multidrug resistant type 1 (MDR1) gene, P-glycoprotein (Pgp), resulting in improved blood-brain barrier (BBB) permeability. Specifically, a taxane analogue, Tx-67, with a succinate group added at the C10 position of Taxol, was synthesized and identified as such a candidate. In comparison studies, Tx-67 had no apparent interactions with Pgp, as demonstrated by the lack of enhanced uptake of rhodamine 123 by brain microvessel endothelial cells (BMECs) in the presence of the agent. By contrast, Taxol exposure substantially enhanced rhodamine 123 uptake by BMECs through inhibition of Pgp. The transport across BMEC monolayers was polarized for both Tx-67 and Taxol with permeation in the apical to basolateral direction greater for Tx-67 and substantially reduced for Taxol relative to basolateral to apical permeation. Taxol and cyclosporin A treatments also did not enhance Tx-67 permeation across BMEC monolayers. In an in situ rat brain perfusion study, Tx-67 was demonstrated to permeate across the BBB at a greater rate than Taxol. These results demonstrate that the Taxol analogue Tx-67 had a reduced interaction with Pgp and, as a consequence, enhanced permeation across the blood-brain barrier in vitro and in situ.
Buchko, Garry W; Perkins, Arden; Parsonage, Derek; Poole, Leslie B; Karplus, P Andrew
2016-04-01
Peroxiredoxins (Prx) are ubiquitous enzymes that reduce peroxides as part of antioxidant defenses and redox signaling. While Prx catalytic activity and sensitivity to hyperoxidative inactivation depend on their dynamic properties, there are few examples where their dynamics has been characterized by NMR spectroscopy. Here, we provide a foundation for studies of the solution properties of peroxiredoxin Q from the plant pathogen Xanthomonas campestris (XcPrxQ) by assigning the observable (1)H(N), (15)N, (13)C(α), (13)C(β), and (13)C' chemical shifts for both the reduced (dithiol) and oxidized (disulfide) states. In the reduced state, most of the backbone amide resonances (149/152, 98 %) can be assigned in the XcPrxQ (1)H-(15)N HSQC spectrum. In contrast, a remarkable 51 % (77) of these amide resonances are not visible in the (1)H-(15)N HSQC spectrum of the disulfide state of the enzyme, indicating a substantial change in backbone dynamics associated with the formation of an intramolecular C48-C84 disulfide bond. PMID:26438558
Douglas, Erica A.; Sheng, Josephine J.; Verley, Jason C.; Carroll, Malcolm S.
2015-06-04
We found that the demand for integration of near infrared optoelectronic functionality with silicon complementary metal oxide semiconductor (CMOS) technology has for many years motivated the investigation of low temperature germanium on silicon deposition processes. Our work describes the development of a high density plasma chemical vapor deposition process that uses a low temperature (<460 °C) in situ germane/argon plasma surface preparation step for epitaxial growth of germanium on silicon. It is shown that the germane/argon plasma treatment sufficiently removes SiO_{x} and carbon at the surface to enable germanium epitaxy. Finally, the use of this surface preparation step demonstrates an alternative way to produce germanium epitaxy at reduced temperatures, a key enabler for increased flexibility of integration with CMOS back-end-of-line fabrication.
Douglas, Erica A.; Sheng, Josephine J.; Verley, Jason C.; Carroll, Malcolm S.
2015-06-04
We found that the demand for integration of near infrared optoelectronic functionality with silicon complementary metal oxide semiconductor (CMOS) technology has for many years motivated the investigation of low temperature germanium on silicon deposition processes. Our work describes the development of a high density plasma chemical vapor deposition process that uses a low temperature (<460 °C) in situ germane/argon plasma surface preparation step for epitaxial growth of germanium on silicon. It is shown that the germane/argon plasma treatment sufficiently removes SiOx and carbon at the surface to enable germanium epitaxy. Finally, the use of this surface preparation step demonstrates anmore » alternative way to produce germanium epitaxy at reduced temperatures, a key enabler for increased flexibility of integration with CMOS back-end-of-line fabrication.« less
Lozovoi, A. Y.; Sheppard, T. J.; Kohanoff, J. J.; Pashov, D. L.; Paxton, A. T.
2014-07-28
We demonstrate a model for stoichiometric and reduced titanium dioxide intended for use in molecular dynamics and other atomistic simulations and based in the polarizable ion tight binding theory. This extends the model introduced in two previous papers from molecular and liquid applications into the solid state, thus completing the task of providing a comprehensive and unified scheme for studying chemical reactions, particularly aimed at problems in catalysis and electrochemistry. As before, experimental results are given priority over theoretical ones in selecting targets for model fitting, for which we used crystal parameters and band gaps of titania bulk polymorphs, rutile and anatase. The model is applied to six low index titania surfaces, with and without oxygen vacancies and adsorbed water molecules, both in dissociated and non-dissociated states. Finally, we present the results of molecular dynamics simulation of an anatase cluster with a number of adsorbed water molecules and discuss the role of edge and corner atoms of the cluster.
Liu, Qi; Jin, Ning; Fan, Zhaoyang; Natsuaki, Yutaka; Tawackoli, Wafa; Pelled, Gadi; Bae, Hyun; Gazit, Dan; Li, Debiao
2013-12-01
The reduced field-of-view (rFOV) turbo-spin-echo (TSE) technique, which effectively suppresses bowel movement artifacts, is developed for the purpose of chemical exchange saturation transfer (CEST) imaging of the intervertebral disc (IVD) in vivo. Attempts to quantify IVD CEST signals in a clinical setting require high reliability and accuracy, which is often compromised in the conventionally used technique. The proposed rFOV TSE CEST method demonstrated significantly superior reproducibility when compared with the conventional technique on healthy volunteers, implying it is a more reliable measurement. Phantom study revealed a linear relation between CEST signal and glycosaminoglycan (GAG) concentration. The feasibility of detecting IVD degeneration was demonstrated on a healthy volunteer, indicating that the proposed method is a promising tool to quantify disc degeneration.
NASA Astrophysics Data System (ADS)
Lozovoi, A. Y.; Pashov, D. L.; Sheppard, T. J.; Kohanoff, J. J.; Paxton, A. T.
2014-07-01
We demonstrate a model for stoichiometric and reduced titanium dioxide intended for use in molecular dynamics and other atomistic simulations and based in the polarizable ion tight binding theory. This extends the model introduced in two previous papers from molecular and liquid applications into the solid state, thus completing the task of providing a comprehensive and unified scheme for studying chemical reactions, particularly aimed at problems in catalysis and electrochemistry. As before, experimental results are given priority over theoretical ones in selecting targets for model fitting, for which we used crystal parameters and band gaps of titania bulk polymorphs, rutile and anatase. The model is applied to six low index titania surfaces, with and without oxygen vacancies and adsorbed water molecules, both in dissociated and non-dissociated states. Finally, we present the results of molecular dynamics simulation of an anatase cluster with a number of adsorbed water molecules and discuss the role of edge and corner atoms of the cluster.
Cheng, Jun; Zhang, Meng; Wu, Gai; Wang, Xin; Zhou, Junhu; Cen, Kefa
2014-06-17
The photoelectrocatalytic (PEC) reduction of CO2 into high-value chemicals is beneficial in alleviating global warming and advancing a low-carbon economy. In this work, Pt-modified reduced graphene oxide (Pt-RGO) and Pt-modified TiO2 nanotubes (Pt-TNT) were combined as cathode and photoanode catalysts, respectively, to form a PEC reactor for converting CO2 into valuable chemicals. XRD, XPS, TEM, AFM, and SEM were employed to characterize the microstructures of the Pt-RGO and Pt-TNT catalysts. Reduction products, such as C2H5OH and CH3COOH, were obtained from CO2 under band gap illumination and biased voltage. A combined liquid product generation rate (CH3OH, C2H5OH, HCOOH, and CH3COOH) of approximately 600 nmol/(h·cm(2)) was observed. Carbon atom conversion rate reached 1,130 nmol/(h·cm(2)), which were much higher than those achieved using Pt-modified carbon nanotubes and platinum carbon as cathode catalysts. PMID:24846604
Cultural horizons for mathematics
NASA Astrophysics Data System (ADS)
Owens, Kay; Paraides, Patricia; Jannok Nutti, Ylva; Johansson, Gunilla; Bennet, Maria; Doolan, Pat; Peckham, Ray; Hill, John; Doolan, Frank; O'Sullivan, Dominic; Murray, Libbey; Logan, Patricia; McNair, Melissa; Sunnari, Vappu; Murray, Beatrice; Miller, Alissa; Nolan, John; Simpson, Alca; Ohrin, Christine; Doolan, Terry; Doolan, Michelle; Taylor, Paul
2011-06-01
As a result of a number of government reports, there have been numerous systemic changes in Indigenous education in Australia revolving around the importance of partnerships with the community. A forum with our local Dubbo community established the importance of working together and developed a model which placed the child in an ecological perspective that particularly noted the role of Elders and the place of the child in the family. However, there was also the issue of curriculum and mathematics education to be addressed. It was recognised that a colonised curriculum reduces the vision of what might be the potential for Indigenous mathematics education. This paper reports on the sharing that developed between our local community and some researchers and teachers from Sweden, Papua New Guinea and New Zealand. It has implications for recognising the impact of testing regimes, the teaching space, understanding the ways children learn, the curriculum, and teacher education. As a result of these discussions, a critical pedagogy that considers culture and place is presented as an ecocultural perspective on mathematics education. This perspective was seen as critical for the curriculum and learning experiences of Indigenous children.
Mathematical Language and Advanced Mathematics Learning
ERIC Educational Resources Information Center
Ferrari, Pier Luigi
2004-01-01
This paper is concerned with the role of language in mathematics learning at college level. Its main aim is to provide a perspective on mathematical language appropriate to effectively interpret students' linguistic behaviors in mathematics and to suggest new teaching ideas. Examples are given to show that the explanation of students' behaviors…
Mathematical Story: A Metaphor for Mathematics Curriculum
ERIC Educational Resources Information Center
Dietiker, Leslie
2015-01-01
This paper proposes a theoretical framework for interpreting the content found in mathematics curriculum in order to offer teachers and other mathematics educators comprehensive conceptual tools with which to make curricular decisions. More specifically, it describes a metaphor of "mathematics curriculum as story" and defines and…
Mathematics for Life: Sustainable Mathematics Education
ERIC Educational Resources Information Center
Renert, Moshe
2011-01-01
Ecological sustainability has not been a major focus of mathematics education research, even though it has attracted considerable attention in other areas of educational research in the past decade. The connections between mathematics education and ecological sustainability are not readily apparent. This paper explores how mathematics educators…
Mathematical Modelling Approach in Mathematics Education
ERIC Educational Resources Information Center
Arseven, Ayla
2015-01-01
The topic of models and modeling has come to be important for science and mathematics education in recent years. The topic of "Modeling" topic is especially important for examinations such as PISA which is conducted at an international level and measures a student's success in mathematics. Mathematical modeling can be defined as using…
Mathematics Anxiety and Attitudes toward Mathematics.
ERIC Educational Resources Information Center
Rounds, James B., Jr.; Hendel, Darwin D.
1980-01-01
Results indicate that the Mathematics Anxiety Rating Scale and the Math Anxiety Scale measure similar components of mathematics-anxiety domain. Mathematics-anxiety scales and Fennema-Sherman scales of Confidence and Effectance Motivation measure similar affective domains and are approximately equal predictors of arithmetic performance. (Author)
Guinee, T P; O'Callaghan, D J
2013-01-01
Scientific studies indicate that the intake of dietary fat and saturated fats in the modern Western diet is excessive and contributes adversely to health, lifestyle, and longevity. In response, manufacturers of cheese and processed cheese products (PCP) are pursuing the development of products with reduced fat contents. The present study investigated the effect of altering the fat level (13.8, 18.2, 22.7, 27.9, and 32.5 g/100g) in PCP on their chemical and physical properties. The PCP were formulated in triplicate to different fat levels using Cheddar cheese, skim milk cheese, anhydrous milk fat, emulsifying salt (ES), NaCl, and water. The formulations were designed to give fixed moisture (~53 g/100g) and ES:protein ratio (0.105). The resultant PCP, and their water-soluble extracts (WSE), prepared from a macerated blend of PCP and water at a weight ratio of 1:2, were analyzed at 4d. Reducing the fat content significantly increased the firmness of the unheated PCP and reduced the flowability and maximum loss tangent (fluidity) of the melted PCP. These changes coincided with increases in the levels of total protein, water-soluble protein, water-insoluble protein, and water-soluble Ca, and a decrease in the molar ratio of water-soluble Ca to soluble P. However, both water-soluble Ca and water-soluble protein decreased when expressed as percentages of total protein and total Ca, respectively, in the PCP. The high level of protein was a major factor contributing to the deterioration in physical properties as the fat content of PCP was reduced. Diluting the protein content or reducing the potential of the protein to aggregate, and thereby form structures that contribute to rigidity, may provide a means for improving quality of reduced-fat PCP by using natural cheese with lower intact casein content and lower calcium:casein ratio, for example, or by decreasing the ratio of sodium phosphate to sodium citrate-based ES. PMID:23992974
Guinee, T P; O'Callaghan, D J
2013-01-01
Scientific studies indicate that the intake of dietary fat and saturated fats in the modern Western diet is excessive and contributes adversely to health, lifestyle, and longevity. In response, manufacturers of cheese and processed cheese products (PCP) are pursuing the development of products with reduced fat contents. The present study investigated the effect of altering the fat level (13.8, 18.2, 22.7, 27.9, and 32.5 g/100g) in PCP on their chemical and physical properties. The PCP were formulated in triplicate to different fat levels using Cheddar cheese, skim milk cheese, anhydrous milk fat, emulsifying salt (ES), NaCl, and water. The formulations were designed to give fixed moisture (~53 g/100g) and ES:protein ratio (0.105). The resultant PCP, and their water-soluble extracts (WSE), prepared from a macerated blend of PCP and water at a weight ratio of 1:2, were analyzed at 4d. Reducing the fat content significantly increased the firmness of the unheated PCP and reduced the flowability and maximum loss tangent (fluidity) of the melted PCP. These changes coincided with increases in the levels of total protein, water-soluble protein, water-insoluble protein, and water-soluble Ca, and a decrease in the molar ratio of water-soluble Ca to soluble P. However, both water-soluble Ca and water-soluble protein decreased when expressed as percentages of total protein and total Ca, respectively, in the PCP. The high level of protein was a major factor contributing to the deterioration in physical properties as the fat content of PCP was reduced. Diluting the protein content or reducing the potential of the protein to aggregate, and thereby form structures that contribute to rigidity, may provide a means for improving quality of reduced-fat PCP by using natural cheese with lower intact casein content and lower calcium:casein ratio, for example, or by decreasing the ratio of sodium phosphate to sodium citrate-based ES.
Mathematics Models in Chemistry--An Innovation for Non-Mathematics and Non-Science Majors
ERIC Educational Resources Information Center
Rash, Agnes M.; Zurbach, E. Peter
2004-01-01
The intention of this article is to present a year-long interdisciplinary course, Mathematical Models in Chemistry. The course is comprised of eleven units, each of which has both a mathematical and a chemical component. A syllabus of the course is given and the format of the class is explained. The interaction of the professors and the content is…
Katsnelson, B A; Tsepilov, N A; Panov, V G; Sutunkova, M P; Varaksin, A N; Gurvich, V B; Minigalieva, I A; Valamina, I E; Makeyev, O H; Meshtcheryakova, E Y
2016-09-01
Sodium fluoride solution was injected i.p. to rats at a dose equivalent to 0.1 LD50 three times a week up to 18 injections. Two thirds of these rats and of the sham-injected ones were exposed to the whole body impact of a 25 mT static magnetic field for 2 or 4 h a day, 5 times a week. For mathematical analysis of the effects they produced in combination, we used a response surface model. This analysis demonstrated that (like in combined toxicity) the combined adverse action of a chemical plus a physical agent was characterized by a diversity of types depending not only on particular effects these types were assessed for but on their level as well. From this point of view, the indices for which at least one statistically significant effect was observed could be classified as identifying (1) single-factor action; (2) additivity; (3) synergism; (4) antagonism (both subadditive unidirectional action and all variants of contradirectional action). Although the classes (2) and (3) taken together encompass a smaller part of the indices, the biological importance of some of them renders the combination of agents studied as posing a higher health risk than that associated with each them acting alone.
Mathematical Modeling of Electronic Devices and Circuits
NASA Astrophysics Data System (ADS)
Singh, B. P.; Singh, Meena; Roy, Sanjay Kumar
2010-11-01
The necessity of modeling lies in the nature of technology and its advancement. The modeling minimizes time and cost of the process involved. The mathematical model provides an insight into the behavior of the physical system that reduces the problem to its essential characteristics. The floating admittance matrix (FAM) approach is an elegant method of mathematical modeling of electronic devices and circuits.
Mathematical Ability Relies on Knowledge, Too
ERIC Educational Resources Information Center
Sweller, John; Clark, Richard E.; Kirschner, Paul A.
2011-01-01
Recent "reform" curricula both ignore the absence of supporting data and completely misunderstand the role of problem solving in cognition. If, the argument goes, teachers are not really teaching people mathematics but rather are teaching them some form of general problem solving, then mathematical content can be reduced in importance. According…
Students as Mathematics Consultants
ERIC Educational Resources Information Center
Jensen, Jennifer L.
2013-01-01
If students are going to develop reasoning and thinking skills, use their mathematical knowledge, and recognize the relevance of mathematics in their lives, they need to experience mathematics in meaningful ways. Only then will their mathematical skills be transferrable to all other parts of their lives. To promote such flexible mathematical…
Transforming Primary Mathematics
ERIC Educational Resources Information Center
Askew, Mike
2011-01-01
What is good mathematics teaching? What is mathematics teaching good for? Who is mathematics teaching for? These are just some of the questions addressed in "Transforming Primary Mathematics", a highly timely new resource for teachers which accessibly sets out the key theories and latest research in primary maths today. Under-pinned by findings…
ERIC Educational Resources Information Center
Morsy, Zaghloul, Ed.; Draxler, Alexandra, Ed.
1979-01-01
A set of articles with the theme "Mathematics for Real Life" is presented. These article titles are: (1) Teaching Mathematics as a Tool for Problem Solving; (2) New Math or New Education; (3) Hand Calculators and Math in Primary School; (4) Mass Media in the Mathematical Training of Polish Primary Teachers; (5) The Goals of Mathematics Teaching in…
Mathematical Epistemologies at Work.
ERIC Educational Resources Information Center
Noss, Richard
2002-01-01
Investigates young people's expression of mathematical ideas with a computer, the nature of mathematical practices, and the problem of mathematical meaning from cognitive and socio-cultural perspectives. Describes a mathematical activity system designed for learning and the role of digital technologies in helping to understand and reshape the…
ERIC Educational Resources Information Center
Cain, David
2007-01-01
This article presents the first part of the closing address given by the author to the 2007 Association of Teachers of Mathematics (ATM) Easter conference at Loughborough. In his closing address, the author focuses on functioning mathematically as opposed to functional mathematics. His view of functional mathematics is that the focus is on someone…
Mathematics Lessons without ...
ERIC Educational Resources Information Center
Cross, Kath; Hibbs, John
2006-01-01
In the Association of Teachers of Mathematics (ATM) Easter conference, 2006, the authors presented a list of important aspects of mathematics lessons, recommended for students to have a positive attitude to mathematics and for teachers to acquire effective teaching. The following are discussed in detail: (1) Mathematics lessons without good…
Xue, JunShuai Zhang, JinCheng Hao, Yue
2015-07-27
Ultrathin-barrier AlN/GaN heterostructures were grown on sapphire substrates by pulsed metal organic chemical vapor deposition (PMOCVD) using indium as a surfactant at a dramatically reduced growth temperature of 830 °C. Upon optimization of growth parameters, an electron mobility of 1398 cm{sup 2}/V s together with a two-dimensional-electron-gas density of 1.3 × 10{sup 13 }cm{sup −2} was obtained for a 4 nm thick AlN barrier. The grown structures featured well-ordered parallel atomic steps with a root-mean-square roughness of 0.15 nm in a 5 × 5 μm{sup 2} area revealed by atomic-force-microscopic image. Finally, the potential of such structures for device application was demonstrated by fabricating and testing under dc operation AlN/GaN high-electron-mobility transistors. These results indicate that this low temperature PMOCVD growth technique is promising for the fabrication of GaN-based electronic devices.
Ribback, Silvia; Sailer, Verena; Böhning, Enrico; Günther, Julia; Merz, Jaqueline; Steinmüller, Frauke; Utpatel, Kirsten; Cigliano, Antonio; Peters, Kristin; Pilo, Maria G.; Evert, Matthias; Calvisi, Diego F.; Dombrowski, Frank
2016-01-01
Activation of the epidermal growth factor receptor (EGFR) signaling pathway promotes the development of hepatocellular adenoma (HCA) and carcinoma (HCC). The selective EGFR inhibitor Gefitinib was found to prevent hepatocarcinogenesis in rat cirrhotic livers. Thus, Gefitinib might reduce progression of pre-neoplastic liver lesions to HCC. In short- and long-term experiments, administration of N-Nitrosomorpholine (NNM) or intrahepatic transplantation of pancreatic islets in diabetic (PTx), thyroid follicles in thyroidectomized (TTx) and ovarian fragments in ovariectomized (OTx) rats was conducted for the induction of foci of altered hepatocytes (FAH). Gefitinib was administered for two weeks (20 mg/kg) or three and nine months (10 mg/kg). In NNM-treated rats, Gefitinib administration decreased the amount of FAH when compared to controls. The amount of HCA and HCC was decreased, but development was not prevented. Upon all transplantation models, proliferative activity of FAH was lower after administration of Gefitinib in short-term experiments. Nevertheless, the burden of HCA and HCC was not changed in later stages. Thus, EGFR inhibition by Gefitinib diminishes chemical and hormonal also induced hepatocarcinogenesis in the initiation stage in the non-cirrhotic liver. However, progression to malignant hepatocellular tumors was not prevented, indicating only a limited relevance of the EGFR signaling cascade in later stages of hepatocarcinogenesis. PMID:27669229
Kim, Jeong Im; Ciesielski, Peter N; Donohoe, Bryon S; Chapple, Clint; Li, Xu
2014-02-01
The phenylpropanoid pathway is responsible for the biosynthesis of diverse and important secondary metabolites including lignin and flavonoids. The reduced epidermal fluorescence8 (ref8) mutant of Arabidopsis (Arabidopsis thaliana), which is defective in a lignin biosynthetic enzyme p-coumaroyl shikimate 3'-hydroxylase (C3'H), exhibits severe dwarfism and sterility. To better understand the impact of perturbation of phenylpropanoid metabolism on plant growth, we generated a chemically inducible C3'H expression construct and transformed it into the ref8 mutant. Application of dexamethasone to these plants greatly alleviates the dwarfism and sterility and substantially reverses the biochemical phenotypes of ref8 plants, including the reduction of lignin content and hyperaccumulation of flavonoids and p-coumarate esters. Induction of C3'H expression at different developmental stages has distinct impacts on plant growth. Although early induction effectively restored the elongation of primary inflorescence stem, application to 7-week-old plants enabled them to produce new rosette inflorescence stems. Examination of hypocotyls of these plants revealed normal vasculature in the newly formed secondary xylem, presumably restoring water transport in the mutant. The ref8 mutant accumulates higher levels of salicylic acid than the wild type, but depletion of this compound in ref8 did not relieve the mutant's growth defects, suggesting that the hyperaccumulation of salicylic acid is unlikely to be responsible for dwarfism in this mutant.
Ribback, Silvia; Sailer, Verena; Böhning, Enrico; Günther, Julia; Merz, Jaqueline; Steinmüller, Frauke; Utpatel, Kirsten; Cigliano, Antonio; Peters, Kristin; Pilo, Maria G; Evert, Matthias; Calvisi, Diego F; Dombrowski, Frank
2016-01-01
Activation of the epidermal growth factor receptor (EGFR) signaling pathway promotes the development of hepatocellular adenoma (HCA) and carcinoma (HCC). The selective EGFR inhibitor Gefitinib was found to prevent hepatocarcinogenesis in rat cirrhotic livers. Thus, Gefitinib might reduce progression of pre-neoplastic liver lesions to HCC. In short- and long-term experiments, administration of N-Nitrosomorpholine (NNM) or intrahepatic transplantation of pancreatic islets in diabetic (PTx), thyroid follicles in thyroidectomized (TTx) and ovarian fragments in ovariectomized (OTx) rats was conducted for the induction of foci of altered hepatocytes (FAH). Gefitinib was administered for two weeks (20 mg/kg) or three and nine months (10 mg/kg). In NNM-treated rats, Gefitinib administration decreased the amount of FAH when compared to controls. The amount of HCA and HCC was decreased, but development was not prevented. Upon all transplantation models, proliferative activity of FAH was lower after administration of Gefitinib in short-term experiments. Nevertheless, the burden of HCA and HCC was not changed in later stages. Thus, EGFR inhibition by Gefitinib diminishes chemical and hormonal also induced hepatocarcinogenesis in the initiation stage in the non-cirrhotic liver. However, progression to malignant hepatocellular tumors was not prevented, indicating only a limited relevance of the EGFR signaling cascade in later stages of hepatocarcinogenesis. PMID:27669229
Mathematical Modelling: A New Approach to Teaching Applied Mathematics.
ERIC Educational Resources Information Center
Burghes, D. N.; Borrie, M. S.
1979-01-01
Describes the advantages of mathematical modeling approach in teaching applied mathematics and gives many suggestions for suitable material which illustrates the links between real problems and mathematics. (GA)
Mathematics and Sports. Mathematical World. Volume 3.
ERIC Educational Resources Information Center
Sadovskii, L. E.; Sadovskii, A. L.
This volume contains some examples of mathematical applications in sports. Sports discussed include tennis, figure skating, gymnastics, track and field, soccer, skiing, hockey, and swimming. Problems and situations are posed and answers with thorough explanations are provided. Chapters include: (1) Mathematics and Sports; (2) What Is Applied…
Mathematics Coursework Regulates Growth in Mathematics Achievement
ERIC Educational Resources Information Center
Ma, Xin; Wilkins, Jesse L. M.
2007-01-01
Using data from the Longitudinal Study of American Youth (LSAY), we examined the extent to which students' mathematics coursework regulates (influences) the rate of growth in mathematics achievement during middle and high school. Graphical analysis showed that students who started middle school with higher achievement took individual mathematics…
Mathematics for Language, Language for Mathematics
ERIC Educational Resources Information Center
Prochazkova, Lenka Tejkalova
2013-01-01
The author discusses the balance and mutual influence of the language of instruction and mathematics in the context of CLIL, Content and Language Integrated Learning. Different aspects of the relationship of language and Mathematics teaching and learning are discussed: the benefits of using a foreign language of instruction, as well as the…
Negotiation of Mathematical Meaning and Learning Mathematics.
ERIC Educational Resources Information Center
Voigt, Jorg
1994-01-01
Presents a case study of a first-grade class and their teacher who were observed as they ascribed mathematical meanings of numbers and of numerical operations to empirical phenomena. Differences in ascriptions led to negotiation of meanings. Discusses some indirect relations between social interaction and mathematics learning. (Contains 60…
ERIC Educational Resources Information Center
Blakley, G. R.
1982-01-01
Reviews mathematical techniques for solving systems of homogeneous linear equations and demonstrates that the algebraic method of balancing chemical equations is a matter of solving a system of homogeneous linear equations. FORTRAN programs using this matrix method to chemical equation balancing are available from the author. (JN)
Gana, Mohamed Lamine; Kebbouche-Gana, Salima; Touzi, Abdelkader; Zorgani, Mohamed Amine; Pauss, André; Lounici, Hakim; Mameri, Nabil
2011-03-01
The present study enlightens the role of the antagonistic potential of nonpathogenic strain B21 against sulfate-reducing bacteria (SRB) consortium. The inhibitor effects of strain B21 were compared with those of the chemical biocide tetrakishydroxymethylphosphonium sulfate (THPS), generally used in the petroleum industry. The biological inhibitor exhibited much better and effective performance. Growth of SRB in coculture with bacteria strain B21 antagonist exhibited decline in SRB growth, reduction in production of sulfides, with consumption of sulfate. The observed effect seems more important in comparison with the effect caused by the tested biocide (THPS). Strain B21, a dominant facultative aerobic species, has salt growth requirement always above 5% (w/v) salts with optimal concentration of 10-15%. Phylogenetic analysis based on partial 16S rRNA gene sequences showed that strain B21 is a member of the genus Bacillus, being most closely related to Bacillus qingdaonensis DQ115802 (94.0% sequence similarity), Bacillus aidingensis DQ504377 (94.0%), and Bacillus salarius AY667494 (92.2%). Comparative analysis of partial 16S rRNA gene sequence data plus physiological, biochemical, and phenotypic features of the novel isolate and related species of Bacillus indicated that strain B21 may represent a novel species within the genus Bacillus, named Bacillus sp. (EMBL, FR671419). The results of this study indicate the application potential of Bacillus strain B21 as a biocontrol agent to fight corrosion in the oil industry.
NASA Astrophysics Data System (ADS)
Aubin, J.; Hartmann, J. M.; Bauer, M.; Moffatt, S.
2016-07-01
We have studied the very low temperature epitaxy of pure Ge and of Ge-rich SiGe alloys in a 200 mm industrial reduced pressure chemical vapour deposition tool. We have, first of all, benchmarked germane (GeH4) and digermane (Ge2H6) for the growth of pure Ge. Used Ge2H6 instead of GeH4 enabled us to dramatically increase the Ge growth rate at temperatures 425 °C and lower (5.6 nm min-1 compared to 0.14 nm min-1 at 350 °C with a Ge2H6 mass-flow one fourth that of GeH4). We have also evaluated at 400 °C, 100 Torr, the impact of the GeH4 or Ge2H6 mass-flow on the Ge growth rate. For a given Ge atomic flow, the higher surface reactivity of digermane yielded roughly five times higher growth rates than with germane. We have then combined digermane with disilane (Si2H6) or dichlorosilane (SiH2Cl2) in order to study the GeSi growth kinetics at 475 °C, 100 Torr. While the SiH2Cl2 mass-flow did not have any clear influence on the GeSi growth rate (with a 14 nm min-1 mean value, then), a Si2H6 mass-flow increase resulted in a slight GeSi growth rate increase (from 11 nm min-1 up to 14 nm min-1). Significantly higher Ge concentrations were otherwise accessed with dichlorosilane than with disilane, in the 77-82% range compared to the 39-53% range, respectively.
Åhs, Fredrik; Savic, Ivanka
2013-01-01
Multiple chemical sensitivity (MCS) is a common condition, characterized by somatic distress upon exposure to odors. As in other idiopathic environmental intolerances, the underlying mechanisms are unknown. Contrary to the expectations it was recently found that persons with MCS activate the odor-processing brain regions less than controls, while their activation of the anterior cingulate cortex (ACC) is increased. The present follow-up study was designed to test the hypotheses that MCS subjects have increased harm avoidance and deviations in the serotonin system, which could render them intolerant to environmental odors. Twelve MCS and 11 control subjects, age 22–44, all working or studying females, were included in a PET study where 5-HT1A receptor binding potential (BP) was assessed after bolus injection of [11C]WAY100635. Psychological profiles were assessed by the Temperament and Character Inventory and the Swedish universities Scales of Personality. All MCS and 12 control subjects were also tested for emotional startle modulation in an acoustic startle test. MCS subjects exhibited significantly increased harm avoidance, and anxiety compared to controls. They also had a reduced 5-HT1A receptor BP in amygdala (p = 0.029), ACC (p = 0.005) (planned comparisons, significance level 0.05), and insular cortex (p = 0.003; significance level p<0.005 with Bonferroni correction), and showed an inverse correlation between degree of anxiety and the BP in the amygdala (planned comparison). No group by emotional category difference was found in the startle test. Increased harm avoidance and the observed changes in the 5-HT1A receptor BP in the regions processing harm avoidance provides a plausible pathophysiological ground for the symptoms described in MCS, and yields valuable information for our general understanding of idiopathic environmental intolerances. PMID:23349968
Perspectives from Mathematics Education.
ERIC Educational Resources Information Center
Sowder, Judith Threadgill
1998-01-01
Explores possible reasons for the gender differences in mathematics problem-solving strategies found in primary-grade students in the study by E. Fennema and others and considers implications of the findings for mathematics instruction. (SLD)
Mathematical and statistical analysis
NASA Technical Reports Server (NTRS)
Houston, A. Glen
1988-01-01
The goal of the mathematical and statistical analysis component of RICIS is to research, develop, and evaluate mathematical and statistical techniques for aerospace technology applications. Specific research areas of interest include modeling, simulation, experiment design, reliability assessment, and numerical analysis.
Developing My Mathematics Identity
ERIC Educational Resources Information Center
Gonzalez, Lidia
2016-01-01
Assuming the role of storyteller, the author uses her experiences as a graduate student and beginning teacher to reflect critically on issues related to mathematics, mathematics education, gender, and diversity.
Mental Mathematics Moves Ahead.
ERIC Educational Resources Information Center
Jones, Pamela
1988-01-01
The author suggests that the efficient use of mathematics in everyday life means translating situations into mathematical contexts, using a calculator and mental methods of calculation. Suggestions for teaching these concepts are included. (PK)
Multi-World Paradigm in Mathematical Learning (1): An Analysis of Mathematics Classes.
ERIC Educational Resources Information Center
Nakahara, Tadao; Sasaki, Tetsuro; Koyama, Masataka; Yamaguchi, Takeshi
2000-01-01
Illustrates two analyses of mathematical learning based on the multi-word paradigm and considers it theoretically. The multi-world paradigm suggests the very important forward direction for research in teaching and learning mathematics because educational phenomena are often complex and can not be reduced to a single theory. (Contains 28…
ERIC Educational Resources Information Center
Clary, Joseph R.; Nery, Karen P.
This set of 20 modules was designed for use primarily to help teach and reinforce the basic mathematics skills in electronics classes. The modules are based on electronics competencies that require mathematics skills, as determined by a panel of high school electronics and mathematics teachers. Each module consists of one or two pages of basic…
ERIC Educational Resources Information Center
Pratt, Dave
2012-01-01
Mathematics is often portrayed as an "abstract" cerebral subject, beyond the reach of many. In response, research with digital technology has led to innovative design in which mathematics can be experienced much like everyday phenomena. This lecture examines how careful design can "phenomenalise" mathematics and support not only engagement but…
Translations toward Connected Mathematics
ERIC Educational Resources Information Center
Applebaum, Mark; Leikin, Roza
2010-01-01
The translation principle allows students to solve problems in different branches of mathematics and thus to develop connectedness in their mathematical knowledge. Successful application of the translation principle depends on the classroom mathematical norms for the development of discussions and the comparison of different solutions to one…
Mathematics and Comprehensive Ideals
ERIC Educational Resources Information Center
Watson, Anne
2011-01-01
This article revisits methods and debates about teaching mathematics that were common in the 1980s and early 1990s, and then moves up to date with the findings from three mathematics departments that set out to make a difference for their lowest attaining students. The methods they used were distinctly focused on core mathematical ideas, and how…
Winning Women into Mathematics.
ERIC Educational Resources Information Center
Kenschaft, Patricia Clark, Ed.; Keith, Sandra Zaroodny, Ed.
Mathematics is an auspicious discipline for young people of both sexes and all ethnic groups. This booklet aims to help members of the Mathematical Association of America (MAA) and others to increase future participation of women in mathematics, to better understand their present roles, and to develop a vision of a world with greater equal…
ERIC Educational Resources Information Center
Martin, Tami S.; Speer, William R.
2009-01-01
This article describes features, consistent messages, and new components of "Mathematics Teaching Today: Improving Practice, Improving Student Learning" (NCTM 2007), an updated edition of "Professional Standards for Teaching Mathematics" (NCTM 1991). The new book describes aspects of high-quality mathematics teaching; offers a model for observing,…
Revisiting Mathematics Manipulative Materials
ERIC Educational Resources Information Center
Swan, Paul; Marshall, Linda
2010-01-01
It is over 12 years since "APMC" published Bob Perry and Peter Howard's research on the use of mathematics manipulative materials in primary mathematics classrooms. Since then the availability of virtual manipulatives and associated access to computers and interactive whiteboards have caused educators to rethink the use of mathematics manipulative…
Rural Mathematics Educator, 2002.
ERIC Educational Resources Information Center
Rural Mathematics Educator, 2002
2002-01-01
This document contains the two issues of "Rural Mathematics Educator" published in 2002. This newsletter of the Appalachian Collaborative Center for Learning, Assessment, and Instruction in Mathematics (ACCLAIM) includes articles on rural mathematics education, as well as information and descriptions of professional development opportunities for…
Mathematics and Global Survival.
ERIC Educational Resources Information Center
Schwartz, Richard H.
This resource was written to provide students with an awareness of critical issues facing the world today. In courses for college students, it can motivate their study of mathematics, teach them how to solve mathematical problems related to current global issues, provide coherence to mathematical studies through a focus on issues of human…
ERIC Educational Resources Information Center
Walshaw, Margaret
2014-01-01
This paper explores contemporary thinking about learning mathematics, and within that, social justice within mathematics education. The discussion first looks at mechanisms offered by conventional explanations on the emancipatory project and then moves towards more recent insights developed within mathematics education. Synergies are drawn between…
Making Mathematics Culturally Relevant.
ERIC Educational Resources Information Center
Moyer, Patricia
2001-01-01
Examines three strands of elementary mathematics--numerals and counting, recording and calculating, and mathematics exploration and play--and provides ways to integrate culture and mathematics experiences in each area. Specific topics include Egyptian methods for multiplication, the abacus, and the words for the numbers 1-10 in seven different…
Mathematical Epistemologies at Work.
ERIC Educational Resources Information Center
Noss, Richard
In this paper, I draw together a corpus of findings derived from two sources: studies of students using computers to learn mathematics, and research into the use of mathematics in professional practice. Using this as a basis, I map some elements of a theoretical framework for understanding the nature of mathematical knowledge in use, and how it is…
ERIC Educational Resources Information Center
Darlington, Ellie
2014-01-01
This article describes part of a study which investigated the role of questions in students' approaches to learning mathematics at the secondary-tertiary interface, focussing on the enculturation of students at the University of Oxford. Use of the Mathematical Assessment Task Hierarchy taxonomy revealed A-level Mathematics and Further Mathematics…
ERIC Educational Resources Information Center
Gallian, Joseph A., Ed.
2010-01-01
"Mathematics and Sports", edited by Joseph A. Gallian, gathers 25 articles that illuminate the power and role of mathematics in the worlds of professional and recreational play. Divided into sections by the kind of sports, the book offers source materials for classroom use and student projects. Readers will encounter mathematical ideas from an…
A "Mathematics Background Check"
ERIC Educational Resources Information Center
Hubisz, John
2009-01-01
Early in my career someone else reported that the best indicator of success in calculus-based physics (CBP) at our school was whether students had taken mathematics in a certain region of New Brunswick. I sat down with a very longtime mathematics teacher and asked him what he thought students should know in mathematics after high school to succeed…
ERIC Educational Resources Information Center
Posey, Johnsie Jo, Ed.; And Others
This manual is a collection of materials and teaching strategies to motivate the development of mathematical ideas in secondary school mathematics programs or in beginning college mathematics programs. The unit is written for the instructor with step-by-step procedures including lists of needed materials. The exercises in this unit also appear in…
Mathematics and Mobile Learning
ERIC Educational Resources Information Center
Sayed, Fayez
2015-01-01
The wide range of Mathematical Apps targeting different mathematical concepts and the various types of mobile devices available present a demanding and challenging problem to the teaching and learning in the field of mathematics. In an attempt to address this issue, a few Apps were selected, implemented and tested in this work. [For complete…
ERIC Educational Resources Information Center
Ortiz-Franco, Luis
An historical perspective reveals that sophisticated mathematical activity has been going on in the Latino culture for thousands of years. This paper provides a general definition of the area of mathematics education that deals with issues of culture and mathematics (ethnomathematics) and defines what is meant by the term Latino in this essay.…
Mathenger Hunt: Mathematics Matters.
ERIC Educational Resources Information Center
Falba, Christy J.; Weiss, Maria J.
1991-01-01
Presented is an activity which shows how mathematics is used in real life and helps to establish a need for mathematics in students' futures. Adapted from a scavenger-hunt idea, this activity helps students to discover that almost every career makes use of mathematics. (KR)
Mathematics. [SITE 2001 Section].
ERIC Educational Resources Information Center
Connell, Michael L., Ed.; Lowery, Norene Vail, Ed.; Harnisch, Delwyn L., Ed.
This document contains the following papers on mathematics from the SITE (Society for Information Technology & Teacher Education) 2001 conference: "Secondary Mathematics Methods Course with Technology Units: Encouraging Pre-Service Teachers To Use Technology" (Rajee Amarasinghe); "Competency Exams in College Mathematics" (Kathy R. Autrey and Leigh…
Applying Mathematical Processes (AMP)
ERIC Educational Resources Information Center
Kathotia, Vinay
2011-01-01
This article provides insights into the "Applying Mathematical Processes" resources, developed by the Nuffield Foundation. It features Nuffield AMP activities--and related ones from Bowland Maths--that were designed to support the teaching and assessment of key processes in mathematics--representing a situation mathematically, analysing,…
Abraham, Ralph
2015-12-01
Is there a world of mathematics above and beyond ordinary reality, as Plato proposed? Or is mathematics a cultural construct? In this short article we speculate on the place of mathematical reality from the perspective of the mystical cosmologies of the ancient traditions of meditation, psychedelics, and divination.
ERIC Educational Resources Information Center
Galligan, Linda
2016-01-01
A "National Numeracy Report" and the Australian Curriculum (2014) have recognised the importance of language in mathematics. The general capabilities contained within the "Australian Curriculum: Mathematics" (2014) highlight literacy as an important tool in the teaching and learning of mathematics, from the interpretation of…
Carey, Emma; Hill, Francesca; Devine, Amy; Szücs, Dénes
2015-01-01
This review considers the two possible causal directions between mathematics anxiety (MA) and poor mathematics performance. Either poor maths performance may elicit MA (referred to as the Deficit Theory), or MA may reduce future maths performance (referred to as the Debilitating Anxiety Model). The evidence is in conflict: the Deficit Theory is supported by longitudinal studies and studies of children with mathematical learning disabilities, but the Debilitating Anxiety Model is supported by research which manipulates anxiety levels and observes a change in mathematics performance. It is suggested that this mixture of evidence might indicate a bidirectional relationship between MA and mathematics performance (the Reciprocal Theory), in which MA and mathematics performance can influence one another in a vicious cycle.
Carey, Emma; Hill, Francesca; Devine, Amy; Szücs, Dénes
2016-01-01
This review considers the two possible causal directions between mathematics anxiety (MA) and poor mathematics performance. Either poor maths performance may elicit MA (referred to as the Deficit Theory), or MA may reduce future maths performance (referred to as the Debilitating Anxiety Model). The evidence is in conflict: the Deficit Theory is supported by longitudinal studies and studies of children with mathematical learning disabilities, but the Debilitating Anxiety Model is supported by research which manipulates anxiety levels and observes a change in mathematics performance. It is suggested that this mixture of evidence might indicate a bidirectional relationship between MA and mathematics performance (the Reciprocal Theory), in which MA and mathematics performance can influence one another in a vicious cycle. PMID:26779093
The History of Mathematics and Mathematical Education
ERIC Educational Resources Information Center
Grattan-Guinness, I.
1977-01-01
Answers to questions which were asked after the author's various lectures in Australia are gathered here. Topics touched upon include "new" mathematics, unknown constants and free variables, propositional functions, linear algebra, arithmetic and geometry, and student assessment. (MN)
Mass Transfer with Chemical Reaction.
ERIC Educational Resources Information Center
DeCoursey, W. J.
1987-01-01
Describes the organization of a graduate course dealing with mass transfer, particularly as it relates to chemical reactions. Discusses the course outline, including mathematics models of mass transfer, enhancement of mass transfer rates by homogeneous chemical reaction, and gas-liquid systems with chemical reaction. (TW)
Mathematics analysis of polymerase chain reaction kinetic curves.
Sochivko, D G; Fedorov, A A; Varlamov, D A; Kurochkin, V E; Petrov, R V
2016-01-01
The paper reviews different approaches to the mathematical analysis of polymerase chain reaction (PCR) kinetic curves. The basic principles of PCR mathematical analysis are presented. Approximation of PCR kinetic curves and PCR efficiency curves by various functions is described. Several PCR models based on chemical kinetics equations are suggested. Decision criteria for an optimal function to describe PCR efficiency are proposed.
Trajectory Calculations in Chemical Kinetics
ERIC Educational Resources Information Center
Hemphill, Gregory L.; White, John M.
1972-01-01
This exercise, suitable for an advanced undergraduate physical chemistry lab, examines the detailed theoretical description of a chemical reaction. Mathematical techniques of moderate complexity serve to introduce some aspects of theoretical chemistry. (Author/TS)
Early childhood mathematics intervention.
Clements, Douglas H; Sarama, Julie
2011-08-19
Preschool and primary grade children have the capacity to learn substantial mathematics, but many children lack opportunities to do so. Too many children not only start behind their more advantaged peers, but also begin a negative trajectory in mathematics. Interventions designed to facilitate their mathematical learning during ages 3 to 5 years have a strong positive effect on these children's lives for many years thereafter.
ERIC Educational Resources Information Center
House, Peggy A.
1994-01-01
Describes some mathematical investigations of the necktie which includes applications of geometry, statistics, data analysis, sampling, probability, symmetry, proportion, problem solving, and business. (MKR)
Mathematics for Teaching: A Form of Applied Mathematics
ERIC Educational Resources Information Center
Stylianides, Gabriel J.; Stylianides, Andreas J.
2010-01-01
In this article we elaborate a conceptualisation of "mathematics for teaching" as a form of applied mathematics (using Bass's idea of characterising mathematics education as a form of applied mathematics) and we examine implications of this conceptualisation for the mathematical preparation of teachers. Specifically, we focus on issues of design…
Using Mathematics Literature with Prospective Secondary Mathematics Teachers
ERIC Educational Resources Information Center
Jett, Christopher C.
2014-01-01
Literature in mathematics has been found to foster positive improvements in mathematics learning. This manuscript reports on a mathematics teacher educator's use of literature via literature circles with 11 prospective secondary mathematics teachers in a mathematics content course. Using survey and reflection data, the author found that…
Finite Mathematics and Discrete Mathematics: Is There a Difference?
ERIC Educational Resources Information Center
Johnson, Marvin L.
Discrete mathematics and finite mathematics differ in a number of ways. First, finite mathematics has a longer history and is therefore more stable in terms of course content. Finite mathematics courses emphasize certain particular mathematical tools which are useful in solving the problems of business and the social sciences. Discrete mathematics…
Exploring Differential Effects of Mathematics Courses on Mathematics Achievement
ERIC Educational Resources Information Center
Ma, Xin; McIntyre, Laureen J.
2005-01-01
Using data from the Longitudinal Study of Mathematics Participation (N = 1,518 students from 34 schools), we investigated the effects of pure and applied mathematics courses on mathematics achievement, controlling for prior mathematics achievement. Results of multilevel modelling showed that the effects of pure mathematics were significant after…
Hands-On Mathematics: Two Cases from Ancient Chinese Mathematics
ERIC Educational Resources Information Center
Wang, Youjun
2009-01-01
In modern mathematical teaching, it has become increasingly emphasized that mathematical knowledge should be taught by problem-solving, hands-on activities, and interactive learning experiences. Comparing the ideas of modern mathematical education with the development of ancient Chinese mathematics, we find that the history of mathematics in…
A Capstone Mathematics Course for Prospective Secondary Mathematics Teachers
ERIC Educational Resources Information Center
Artzt, Alice F.; Sultan, Alan; Curcio, Frances R.; Gurl, Theresa
2012-01-01
This article describes an innovative capstone mathematics course that links college mathematics with school mathematics and pedagogy. It describes how college juniors in a secondary mathematics teacher preparation program engage in leadership experiences that enable them to learn mathematics for teaching while developing student-centered…
Junka, Adam F; Szymczyk, Patrycja; Secewicz, Anna; Pawlak, Andrzej; Smutnicka, Danuta; Ziółkowski, Grzegorz; Bartoszewicz, Marzenna; Chlebus, Edward
2016-01-01
In our previous work we reported the impact of hydrofluoric and nitric acid used for chemical polishing of Ti-6Al-7Nb scaffolds on decrease of the number of Staphylococcus aureus biofilm forming cells. Herein, we tested impact of the aforementioned substances on biofilm of Gram-negative microorganism, Pseudomonas aeruginosa, dangerous pathogen responsible for plethora of implant-related infections. The Ti-6Al-7Nb scaffolds were manufactured using Selective Laser Melting method. Scaffolds were subjected to chemical polishing using a mixture of nitric acid and fluoride or left intact (control group). Pseudomonal biofilm was allowed to form on scaffolds for 24 hours and was removed by mechanical vortex shaking. The number of pseudomonal cells was estimated by means of quantitative culture and Scanning Electron Microscopy. The presence of nitric acid and fluoride on scaffold surfaces was assessed by means of IR and rentgen spetorscopy. Quantitative data were analysed using the Mann-Whitney test (P ≤ 0.05). Our results indicate that application of chemical polishing correlates with significant drop of biofilm-forming pseudomonal cells on the manufactured Ti-6Al-7Nb scaffolds ( p = 0.0133, Mann-Whitney test) compared to the number of biofilm-forming cells on non-polished scaffolds. As X-ray photoelectron spectroscopy revealed the presence of fluoride and nitrogen on the surface of scaffold, we speculate that drop of biofilm forming cells may be caused by biofilm-supressing activity of these two elements.
Junka, Adam F; Szymczyk, Patrycja; Secewicz, Anna; Pawlak, Andrzej; Smutnicka, Danuta; Ziółkowski, Grzegorz; Bartoszewicz, Marzenna; Chlebus, Edward
2016-01-01
In our previous work we reported the impact of hydrofluoric and nitric acid used for chemical polishing of Ti-6Al-7Nb scaffolds on decrease of the number of Staphylococcus aureus biofilm forming cells. Herein, we tested impact of the aforementioned substances on biofilm of Gram-negative microorganism, Pseudomonas aeruginosa, dangerous pathogen responsible for plethora of implant-related infections. The Ti-6Al-7Nb scaffolds were manufactured using Selective Laser Melting method. Scaffolds were subjected to chemical polishing using a mixture of nitric acid and fluoride or left intact (control group). Pseudomonal biofilm was allowed to form on scaffolds for 24 hours and was removed by mechanical vortex shaking. The number of pseudomonal cells was estimated by means of quantitative culture and Scanning Electron Microscopy. The presence of nitric acid and fluoride on scaffold surfaces was assessed by means of IR and rentgen spetorscopy. Quantitative data were analysed using the Mann-Whitney test (P ≤ 0.05). Our results indicate that application of chemical polishing correlates with significant drop of biofilm-forming pseudomonal cells on the manufactured Ti-6Al-7Nb scaffolds ( p = 0.0133, Mann-Whitney test) compared to the number of biofilm-forming cells on non-polished scaffolds. As X-ray photoelectron spectroscopy revealed the presence of fluoride and nitrogen on the surface of scaffold, we speculate that drop of biofilm forming cells may be caused by biofilm-supressing activity of these two elements. PMID:27150429
Remedial Mathematics for Quantum Chemistry
ERIC Educational Resources Information Center
Koopman, Lodewijk; Brouwer, Natasa; Heck, Andre; Buma, Wybren Jan
2008-01-01
Proper mathematical skills are important for every science course and mathematics-intensive chemistry courses rely on a sound mathematical pre-knowledge. In the first-year quantum chemistry course at this university, it was noticed that many students lack basic mathematical knowledge. To tackle the mathematics problem, a remedial mathematics…
Solving Common Mathematical Problems
NASA Technical Reports Server (NTRS)
Luz, Paul L.
2005-01-01
Mathematical Solutions Toolset is a collection of five software programs that rapidly solve some common mathematical problems. The programs consist of a set of Microsoft Excel worksheets. The programs provide for entry of input data and display of output data in a user-friendly, menu-driven format, and for automatic execution once the input data has been entered.
Issues in Teaching Mathematics
ERIC Educational Resources Information Center
Ediger, Marlow
2013-01-01
In this article, the author states that there are selected issues in mathematics instruction that educators should be well aware of when planning lessons and units of study. These issues provide a basis for thought and discussion when assisting pupils to attain more optimally. Purposeful studying of issues guides mathematics teachers in…
Mathematics: The Universal Language?
ERIC Educational Resources Information Center
Hoffert, Sharon B.
2009-01-01
Mathematics is considered the universal language, but students who speak languages other than English have difficulty doing mathematics in English. For instance, because of a lack of familiarity with the problem's context, many have trouble understanding exactly what operations to perform. In the United States, approximately one in seven students…
Mathematical techniques: A compilation
NASA Technical Reports Server (NTRS)
1975-01-01
Articles on theoretical and applied mathematics are introduced. The articles cover information that might be of interest to workers in statistics and information theory, computational aids that could be used by scientists and engineers, and mathematical techniques for design and control.
Modularizing Remedial Mathematics
ERIC Educational Resources Information Center
Wong, Aaron
2013-01-01
As remedial mathematics education has become an increasingly important topic of conversation in higher education. Mathematics departments have been put under increased pressure to change their programs to increase the student success rate. A number of models have been introduced over the last decade that represent a wide range of new ideas and…
Dyslexia, Dyspraxia and Mathematics.
ERIC Educational Resources Information Center
Yeo, Dorian
This book explores how primary school children with dyslexia or dyspraxia and difficulty in math can learn math and provides practical support and detailed teaching suggestions. It considers cognitive features that underlie difficulty with mathematics generally or with specific aspects of mathematics. It outlines the ways in which children usually…
Developing Mathematically Promising Students.
ERIC Educational Resources Information Center
Sheffield, Linda Jensen, Ed.
This book, written on the recommendation of the Task Force on Mathematically Promising Students, investigates issues involving the development of promising mathematics students. Recommendations are made concerning topics such as the definition of promising students; the identification of such students; appropriate curriculum, instruction, and…
Mathematics in Power Technology.
ERIC Educational Resources Information Center
Trombley, Carl; And Others
This mathematics curriculum is designed to be taught by the technology education teacher during the power technology class over a period of 2 years. It is intended to be elective in nature; upon successful completion of both years, one-half credit in mathematics is to be awarded. A list of the academic competencies contained in the curriculum…
Experimenting with Mathematical Biology
ERIC Educational Resources Information Center
Sanft, Rebecca; Walter, Anne
2016-01-01
St. Olaf College recently added a Mathematical Biology concentration to its curriculum. The core course, Mathematics of Biology, was redesigned to include a wet laboratory. The lab classes required students to collect data and implement the essential modeling techniques of formulation, implementation, validation, and analysis. The four labs…
ERIC Educational Resources Information Center
Sharp, Karen Tobey
This paper cites information received from a number of sources, e.g., mathematics teachers in two-year colleges, publishers, and convention speakers, about the nature of discrete mathematics and about what topics a course in this subject should contain. Note is taken of the book edited by Ralston and Young which discusses the future of college…
Consumer Mathematics Curriculum Guide.
ERIC Educational Resources Information Center
Louisiana State Dept. of Education, Baton Rouge.
This guide for high school consumer mathematics (one in a set of curriculum guides developed by Louisiana statewide mathematics curriculum committees) contains a course outline, performance objectives, and coordinated activities designed to teach skills that students will need as citizens and consumers. Background on the development,…
Business Mathematics Curriculum.
ERIC Educational Resources Information Center
EASTCONN Regional Educational Services Center, North Windham, CT.
This curriculum guide for teaching business mathematics in the Connecticut Vocational-Technical School System is based on the latest thinking of instructors in the field, suggestions from mathematics authorities, and current instructional approaches in education. The curriculum guide consists of six sections: (1) career relationships and…
Astronomy and Mathematics Education
NASA Astrophysics Data System (ADS)
Ros, Rosa M.
There are many European countries where Astronomy does not appear as a specific course on the secondary school. In these cases Astronomy content can be introduced by means of other subjects. There are some astronomical topics within the subject of Physics but this talk concerns introducing Astronomy in Mathematics classes. Teaching Astronomy through Mathematics would result in more exposure than through Physics as Mathematics is more prevalent in the curriculum. Generally it is not easy to motivate students in Mathematics but they are motivated to find out more about the universe and Astronomy current events than appears in the media. This situation can be an excellent introduction to several mathematics topics. The teachers in secondary and high school can use this idea in order to present more attractive mathematics courses. In particular some different examples will be offered regarding * Angles and spherical coordinates considering star traces * Logarithms and visual magnitudes * Plane trigonometry related orbital movements * Spherical trigonometry in connection with ecliptic obliquity * Conic curves related to sundial at several latitudes Some students do not enjoy studying Mathematics but they can be attracted by practical situations using Applied Mathematics: Astronomy is always very attractive to teenagers.
Quality Teaching in Mathematics
ERIC Educational Resources Information Center
Ediger, Marlow
2012-01-01
The best teaching possible needs to accrue in the mathematics curriculum. Pupils also need to become proficient in using mathematics in every day situations in life. Individuals buy goods and services. They pay for these in different ways, including cash. Here, persons need to be able to compute the total cost of items purchased and then pay for…
Learning Mathematics while Black
ERIC Educational Resources Information Center
Martin, Danny Bernard
2012-01-01
While research by scholars has contributed greatly to an emerging knowledge base on Black children and mathematics, there continues to be a dire need for insightful research that de-centers longstanding accounts that have contributed to the construction of Black children as mathematically illiterate and as less than ideal learners relative to…
Intermediate Mathematics Study Guide.
ERIC Educational Resources Information Center
Stanford Univ., CA. School Mathematics Study Group.
This SMSG study guide is intended to provide teachers who use "Intermediate Mathematics," as a textbook with references to materials which will help them to gain a better understanding of the mathematics contained in the text. For each chapter of the text a brief resume of its content is followed by a list of annotated references which are…
ERIC Educational Resources Information Center
Hallenberg, Harvey
1995-01-01
Presents ideas for creating mathematical classroom activities associated with the history of mathematics: calculating sums and products the way ancient Greeks did it, using an abacus or moving stones on a sanded floor, and engaging elementary students through role playing specific mathematicians. Suggests that through such techniques, mathematics…
Designing Assessment for Mathematics
ERIC Educational Resources Information Center
Depka, Eileen
2007-01-01
Teaching mathematics in today's world requires practices and procedures integrated with performance tasks that actively involve students. In this second edition of Designing Rubrics for Mathematics, Eileen Depka clarifies the purpose of rubrics in math instruction and illustrates the relationship between assessment, rubrics, and the National…
Mathematical Graphic Organizers
ERIC Educational Resources Information Center
Zollman, Alan
2009-01-01
As part of a math-science partnership, a university mathematics educator and ten elementary school teachers developed a novel approach to mathematical problem solving derived from research on reading and writing pedagogy. Specifically, research indicates that students who use graphic organizers to arrange their ideas improve their comprehension…
Mathematics. [SITE 2002 Section].
ERIC Educational Resources Information Center
Connell, Michael L., Ed.; Lowery, Norene Vail, Ed.; Harnisch, Delwyn L., Ed.
This document contains the following papers on mathematics from the SITE (Society for Information Technology & Teacher Education) 2002 conference: (1) "Teachers' Learning of Mathematics in the Presence of Technology: Participatory Cognitive Apprenticeship" (Mara Alagic); (2) "A Fractal Is a Pattern in Your Neighborhood" (Craig N. Bach); (3)…
ERIC Educational Resources Information Center
Stallings, L. Lynn
2007-01-01
This article proposes four strategies for posing mathematics problems that raise the cognitive demands of the tasks given to students. Each strategy is illustrated with three common middle school mathematics examples: finding the greatest common factor, finding area or perimeter, and finding the equation of a line. Posing these types of problems…
The Impossible in Mathematics.
ERIC Educational Resources Information Center
Adler, Irving
The material in this reprint, with minor editorial changes, is from the chapter "Doing the Impossible" in MONKEY BUSINESS by Irving Adler. This 25-page booklet contains brief accounts of historical attempts to prove impossible problems in mathematics. The mathematical recreations in this booklet of geometric constructions include the trisection…
Strengthen Your Mathematical Muscles
ERIC Educational Resources Information Center
Wohlhuter, Kay A.; Breyfogle, M. Lynn; McDuffie, Amy Roth
2010-01-01
Developing deep knowledge and understanding of mathematics is a lifelong process, and building the foundation for teachers' development must begin in preservice preparation and continue throughout one's professional life. While teaching mathematics content courses and methods courses, the authors have found that preservice elementary school…
Mathematics: Content and Pedagogy
ERIC Educational Resources Information Center
Ediger, Marlow
2009-01-01
The debate has gone on for some time in terms of which is more salient for the teacher to be well versed in, mathematical content versus methods and approaches in teaching. Both are salient. They cannot be separated from each other. The mathematics teacher must indeed have broad, in-depth knowledge of subject matter as well as in teaching and…
Mathematics Education in Argentina
ERIC Educational Resources Information Center
Varsavsky, Cristina; Anaya, Marta
2009-01-01
This article gives an overview of the state of mathematics education in Argentina across all levels, in the regional and world contexts. Statistics are drawn from Mercosur and UNESCO data bases, World Education Indicators and various national time-series government reports. Mathematics results in national testing programmes, Programme for…
[Collected Papers on Mathematics.
ERIC Educational Resources Information Center
Connell, Michael L., Ed.
This document contains the following papers on issues related to mathematics in technology and teacher education: "A Case for Strong Conceptualization in Technology Enhanced Mathematics Instruction" (Michael L. Connell and Delwyn L. Harnisch); "Faculty/Student Collaboration in Education and Math--Using the Web To Improve Student Learning and…
Discrete Mathematics Re "Tooled."
ERIC Educational Resources Information Center
Grassl, Richard M.; Mingus, Tabitha T. Y.
1999-01-01
Indicates the importance of teaching discrete mathematics. Describes how the use of technology can enhance the teaching and learning of discrete mathematics. Explorations using Excel, Derive, and the TI-92 proved how preservice and inservice teachers experienced a new dimension in problem solving and discovery. (ASK)
ERIC Educational Resources Information Center
Fennema, Elizabeth, Ed.; Leder, Gilah C., Ed.
This book reports on various studies that have increased our understanding of why females and males learn different kinds and amounts of mathematics. In particular, this book explicates the Autonomous Learning Behavior model, proposed by Fennema and Peterson, which is a possible explanation of the development of gender differences in mathematics.…
Mathematics Knowledge for Teaching
ERIC Educational Resources Information Center
Mohr, Margaret
2006-01-01
Research indicates that U. S. teachers' mathematical knowledge continues to be weak, and there is an inherent difference between the mathematical knowledge needed to be an effective teacher and that needed by a mathematician. In this article, the author discusses pedagogical content knowledge. According to Schulman (1987), pedagogical content…
ERIC Educational Resources Information Center
Iben, Miriam F.
1991-01-01
Examines seventh and eighth grade students in Australia, Japan, and the United States for attitudes related to mathematics, and the relationship these attitudes have to students' development of abstract mathematical thought and spatial relations. Study uses the Iowa Algebra Aptitude Test, Differential Aptitude Test-Spatial Relations, and the…
Developing Mathematical Vocabulary.
ERIC Educational Resources Information Center
Monroe, Eula Ewing; Orme, Michelle P.
2002-01-01
This article discusses the importance of mathematical vocabulary, difficulties students encounter in learning this vocabulary, and some instructional strategies. Two general methods for teaching vocabulary are discussed: context and explicit vocabulary instruction. The methods are summarized as they apply to mathematical vocabulary instruction and…
ERIC Educational Resources Information Center
Sharp, John
2012-01-01
This relationship is omnipresent to those who appreciate the shared attributes of these two areas of creativity. The dynamic nature of media, and further study, enable mathematicians and artists to present new and exciting manifestations of the "mathematics in art", and the "art in mathematics". The illustrative images of the relationship--that…
NASA Astrophysics Data System (ADS)
Rohrlich, Fritz
2011-12-01
Classical and the quantum mechanical sciences are in essential need of mathematics. Only thus can the laws of nature be formulated quantitatively permitting quantitative predictions. Mathematics also facilitates extrapolations. But classical and quantum sciences differ in essential ways: they follow different laws of logic, Aristotelian and non-Aristotelian logics, respectively. These are explicated.
Business Mathematics. Mathematics Curriculum Guide (Career Oriented).
ERIC Educational Resources Information Center
Nuschler, Alexandra; And Others
The curriculum guide correlates concepts in business mathematics with career-oriented concepts and activities. The curriculum outline format gives the concepts to be taught, matched with related career-oriented performance objectives, concepts, and suggested instructional activities in facing page layouts. The outline is divided into the major…
Technical Mathematics: Restructure of Technical Mathematics.
ERIC Educational Resources Information Center
Flannery, Carol A.
Designed to accompany a series of videotapes, this textbook provides information, examples, problems, and solutions relating to mathematics and its applications in technical fields. Chapter I deals with basic arithmetic, providing information on fractions, decimals, ratios, proportions, percentages, and order of operations. Chapter II focuses on…
ERIC Educational Resources Information Center
Hebert, Michael A.; Powell, Sarah R.
2016-01-01
Increasingly, students are expected to write about mathematics. Mathematics writing may be informal (e.g., journals, exit slips) or formal (e.g., writing prompts on high-stakes mathematics assessments). In order to develop an effective mathematics-writing intervention, research needs to be conducted on how students organize mathematics writing and…
Assessing Students Beliefs about Mathematics.
ERIC Educational Resources Information Center
Spangler, Denise A.
1992-01-01
Presents 11 open-ended questions that can be presented to students and teachers at all educational levels in various formats to assess mathematical beliefs. Questions investigate beliefs toward mathematics, the problem-solving process, mathematicians, and mathematical applications. (MDH)
Kim, Cheon-Jei; Kim, Hyun-Wook; Hwang, Ko-Eun; Song, Dong-Heon; Ham, Youn-Kyung; Choi, Ji-Hun
2016-01-01
In this study, we investigated the effects of reducing fat levels from 30% to 25, 20, and 15% by substituting pork fat with water and pumpkin fiber (2%) on the quality of frankfurters compared with control. Decreasing the fat concentration from 30% to 15% significantly increased moisture content, redness of meat batter and frankfurter, cooking loss, and water exudation, and decreased fat content, energy value, pH, and lightness of meat batter and frankfurter, hardness, cohesiveness, gumminess, chewiness, and apparent viscosity. The addition of 2% pumpkin fiber was significantly increased moisture content, yellowness of meat batter and frankfurter, hardness, cohesiveness, gumminess, chewiness, and apparent viscosity, whereas reduced cooking loss and emulsion stability. The treatment of reduced-fat frankfurters formulated with 20 and 25% fat levels and with pumpkin fiber had sensory properties similar to the high-fat control frankfurters. The results demonstrate that when the reduced-fat frankfurter with 2% added pumpkin fiber and water replaces fat levels can be readily made with high quality and acceptable sensory properties. PMID:27433101
Kim, Cheon-Jei; Kim, Hyun-Wook; Hwang, Ko-Eun; Song, Dong-Heon; Ham, Youn-Kyung; Choi, Ji-Hun; Kim, Young-Boong; Choi, Yun-Sang
2016-01-01
In this study, we investigated the effects of reducing fat levels from 30% to 25, 20, and 15% by substituting pork fat with water and pumpkin fiber (2%) on the quality of frankfurters compared with control. Decreasing the fat concentration from 30% to 15% significantly increased moisture content, redness of meat batter and frankfurter, cooking loss, and water exudation, and decreased fat content, energy value, pH, and lightness of meat batter and frankfurter, hardness, cohesiveness, gumminess, chewiness, and apparent viscosity. The addition of 2% pumpkin fiber was significantly increased moisture content, yellowness of meat batter and frankfurter, hardness, cohesiveness, gumminess, chewiness, and apparent viscosity, whereas reduced cooking loss and emulsion stability. The treatment of reduced-fat frankfurters formulated with 20 and 25% fat levels and with pumpkin fiber had sensory properties similar to the high-fat control frankfurters. The results demonstrate that when the reduced-fat frankfurter with 2% added pumpkin fiber and water replaces fat levels can be readily made with high quality and acceptable sensory properties.
Horita, C N; Morgano, M A; Celeghini, R M S; Pollonio, M A R
2011-12-01
Blends of calcium, magnesium and potassium chloride were used to partially replace sodium chloride (50-75%) in reduced-fat mortadella formulations. The presence of calcium chloride reduced the emulsion stability, cooking yield, elasticity and cohesiveness and increased hardness; however, it yielded the best sensory acceptance when 50% NaCl was replaced by 25% CaCl(2) and 25% KCl. There was no effect of the salt substitutes on mortadella color, appearance and aroma. All salt combinations studied showed stable lipid oxidation during its shelf life. The use of a blend with 1% NaCl, 0.5% KCl and 0.5% MgCl(2) resulted in the best emulsion stability, but the worst scores for flavor. This study suggests that it is possible to reduce the sodium chloride concentration by 50% in reduced-fat mortadella using the studied salt combinations with necessary adjustments to optimize the sensory properties (MgCl(2) 25%; KCl 25%) or emulsion stability (CaCl(2) 25%; KCl 25%).
Kim, Cheon-Jei; Kim, Hyun-Wook; Hwang, Ko-Eun; Song, Dong-Heon; Ham, Youn-Kyung; Choi, Ji-Hun; Kim, Young-Boong; Choi, Yun-Sang
2016-01-01
In this study, we investigated the effects of reducing fat levels from 30% to 25, 20, and 15% by substituting pork fat with water and pumpkin fiber (2%) on the quality of frankfurters compared with control. Decreasing the fat concentration from 30% to 15% significantly increased moisture content, redness of meat batter and frankfurter, cooking loss, and water exudation, and decreased fat content, energy value, pH, and lightness of meat batter and frankfurter, hardness, cohesiveness, gumminess, chewiness, and apparent viscosity. The addition of 2% pumpkin fiber was significantly increased moisture content, yellowness of meat batter and frankfurter, hardness, cohesiveness, gumminess, chewiness, and apparent viscosity, whereas reduced cooking loss and emulsion stability. The treatment of reduced-fat frankfurters formulated with 20 and 25% fat levels and with pumpkin fiber had sensory properties similar to the high-fat control frankfurters. The results demonstrate that when the reduced-fat frankfurter with 2% added pumpkin fiber and water replaces fat levels can be readily made with high quality and acceptable sensory properties. PMID:27433101
Are physicists afraid of mathematics?
NASA Astrophysics Data System (ADS)
Kollmer, Jonathan E.; Pöschel, Thorsten; Gallas, Jason A. C.
2015-01-01
A recent study claimed that heavy use of equations impedes communication among biologists, as measured by the ability to attract citations from peers. It was suggested that to increase the probability of being cited one should reduce the density of equations in papers, that equations should be moved to appendices, and that math training among biologists should be improved. Here, we report a detailed study of the citation habits among physicists, a community that has traditionally strong training and dependence on mathematical formulations. Is it possible to correlate statistical citation patterns and fear of mathematics in a community whose work strongly depends on equations? By performing a systematic analysis of the citation counts of papers published in one of the leading journals in physics covering all its disciplines, we find striking similarities with distribution of citations recorded in biological sciences. However, based on the standard deviations in citation data of both communities, biologists and physicists, we argue that trends in statistical indicators are not reliable to unambiguously blame mathematics for the existence or lack of citations. We digress briefly about other statistical trends that apparently would also enhance citation success.
Mathematics as verbal behavior.
Marr, M Jackson
2015-04-01
"Behavior which is effective only through the mediation of other persons has so many distinguishing dynamic and topographical properties that a special treatment is justified and indeed demanded" (Skinner, 1957, p. 2). Skinner's demand for a special treatment of verbal behavior can be extended within that field to domains such as music, poetry, drama, and the topic of this paper: mathematics. For centuries, mathematics has been of special concern to philosophers who have continually argued to the present day about what some deem its "special nature." Two interrelated principal questions have been: (1) Are the subjects of mathematical interest pre-existing in some transcendental realm and thus are "discovered" as one might discover a new planet; and (2) Why is mathematics so effective in the practices of science and engineering even though originally such mathematics was "pure" with applications neither contemplated or even desired? I argue that considering the actual practice of mathematics in its history and in the context of acquired verbal behavior one can address at least some of its apparent mysteries. To this end, I discuss some of the structural and functional features of mathematics including verbal operants, rule-and contingency-modulated behavior, relational frames, the shaping of abstraction, and the development of intuition. How is it possible to understand Nature by properly talking about it? Essentially, it is because nature taught us how to talk. PMID:25595115
Mathematics as verbal behavior.
Marr, M Jackson
2015-04-01
"Behavior which is effective only through the mediation of other persons has so many distinguishing dynamic and topographical properties that a special treatment is justified and indeed demanded" (Skinner, 1957, p. 2). Skinner's demand for a special treatment of verbal behavior can be extended within that field to domains such as music, poetry, drama, and the topic of this paper: mathematics. For centuries, mathematics has been of special concern to philosophers who have continually argued to the present day about what some deem its "special nature." Two interrelated principal questions have been: (1) Are the subjects of mathematical interest pre-existing in some transcendental realm and thus are "discovered" as one might discover a new planet; and (2) Why is mathematics so effective in the practices of science and engineering even though originally such mathematics was "pure" with applications neither contemplated or even desired? I argue that considering the actual practice of mathematics in its history and in the context of acquired verbal behavior one can address at least some of its apparent mysteries. To this end, I discuss some of the structural and functional features of mathematics including verbal operants, rule-and contingency-modulated behavior, relational frames, the shaping of abstraction, and the development of intuition. How is it possible to understand Nature by properly talking about it? Essentially, it is because nature taught us how to talk.
Boisvert, Ronald F.; Donahue, Michael J.; Lozier, Daniel W.; McMichael, Robert; Rust, Bert W.
2001-01-01
In this paper we describe the role that mathematics plays in measurement science at NIST. We first survey the history behind NIST’s current work in this area, starting with the NBS Math Tables project of the 1930s. We then provide examples of more recent efforts in the application of mathematics to measurement science, including the solution of ill-posed inverse problems, characterization of the accuracy of software for micromagnetic modeling, and in the development and dissemination of mathematical reference data. Finally, we comment on emerging issues in measurement science to which mathematicians will devote their energies in coming years. PMID:27500024
The Greatest Mathematical Discovery?
Bailey, David H.; Borwein, Jonathan M.
2010-05-12
What mathematical discovery more than 1500 years ago: (1) Is one of the greatest, if not the greatest, single discovery in the field of mathematics? (2) Involved three subtle ideas that eluded the greatest minds of antiquity, even geniuses such as Archimedes? (3) Was fiercely resisted in Europe for hundreds of years after its discovery? (4) Even today, in historical treatments of mathematics, is often dismissed with scant mention, or else is ascribed to the wrong source? Answer: Our modern system of positional decimal notation with zero, together with the basic arithmetic computational schemes, which were discovered in India about 500 CE.
Mathematization in introductory physics
NASA Astrophysics Data System (ADS)
Brahmia, Suzanne M.
Mathematization is central to STEM disciplines as a cornerstone of the quantitative reasoning that characterizes these fields. Introductory physics is required for most STEM majors in part so that students develop expert-like mathematization. This dissertation describes coordinated research and curriculum development for strengthening mathematization in introductory physics; it blends scholarship in physics and mathematics education in the form of three papers. The first paper explores mathematization in the context of physics, and makes an original contribution to the measurement of physics students' struggle to mathematize. Instructors naturally assume students have a conceptual mastery of algebra before embarking on a college physics course because these students are enrolled in math courses beyond algebra. This paper provides evidence that refutes the validity of this assumption and categorizes some of the barriers students commonly encounter with quantification and representing ideas symbolically. The second paper develops a model of instruction that can help students progress from their starting points to their instructor's desired endpoints. Instructors recognize that the introductory physics course introduces new ideas at an astonishing rate. More than most physicists realize, however, the way that mathematics is used in the course is foreign to a large portion of class. This paper puts forth an instructional model that can move all students toward better quantitative and physical reasoning, despite the substantial variability of those students' initial states. The third paper describes the design and testing of curricular materials that foster mathematical creativity to prepare students to better understand physics reasoning. Few students enter introductory physics with experience generating equations in response to specific challenges involving unfamiliar quantities and units, yet this generative use of mathematics is typical of the thinking involved in
Warren, Linda P.; Hornback, Chris; Strom, Daniel J.
2006-08-01
In the aftermath of a chemical, biological, or radiological (CBR) attack, decontamination of people and infrastructure will be needed. Decontamination inevitably produces wastewater, and wastewater treatment plants (WTPs) need to know how to handle decontamination wastewater. This article describes CBR substances; planning, coordinating, and communicating responses across agencies; planning within a utility; coordination with local emergency managers and first responders; mitigating effects of decontamination wastewater; and mitigating effects on utility personnel. Planning for Decontamination Wastewater: A Guide for Utilities, the document on which this article is based, was developed under a cooperative agreement from the U.S. Environmental Protection Agency by the National Association of Clean Water Agencies (NACWA) and its contractor, CH2MHILL, Inc.
A mathematical model for jet engine combustor pollutant emissions
NASA Technical Reports Server (NTRS)
Boccio, J. L.; Weilerstein, G.; Edelman, R. B.
1973-01-01
Mathematical modeling for the description of the origin and disposition of combustion-generated pollutants in gas turbines is presented. A unified model in modular form is proposed which includes kinetics, recirculation, turbulent mixing, multiphase flow effects, swirl and secondary air injection. Subelements of the overall model were applied to data relevant to laboratory reactors and practical combustor configurations. Comparisons between the theory and available data show excellent agreement for basic CO/H2/Air chemical systems. For hydrocarbons the trends are predicted well including higher-than-equilibrium NO levels within the fuel rich regime. Although the need for improved accuracy in fuel rich combustion is indicated, comparisons with actual jet engine data in terms of the effect of combustor-inlet temperature is excellent. In addition, excellent agreement with data is obtained regarding reduced NO emissions with water droplet and steam injection.
Benjamin Banneker's Mathematical Puzzles.
ERIC Educational Resources Information Center
Mahoney, John F.
2003-01-01
Benjamin Banneker, a self-taught African American mathematician, kept a journal containing a number of mathematical puzzles. Explores four of these puzzles, 200 years later, with the aid of 21st century technology. (Author/NB)
Mathematics Case Methods Project.
ERIC Educational Resources Information Center
Barnett, Carne S.
1998-01-01
Presents an overview and analysis of the Mathematics Case Methods Project, which uses cases in order to examine and reflect upon teaching. Focuses on a special kind of teacher knowledge, coined pedagogical-content knowledge. (ASK)
Standards in Mathematics Teaching.
ERIC Educational Resources Information Center
Brookes, Bill
1978-01-01
This article is based on a lecture given at the 1978 Easter Course at Padgate College of Higher Education. The lecture is an analysis of the complexity of mathematics teaching and the setting of teaching standards. (MN)
Reciprocal Relationships between Attitude toward Mathematics and Achievement in Mathematics.
ERIC Educational Resources Information Center
Ma, Xin
1997-01-01
This study examined reciprocal relationships between attitude toward mathematics and mathematics achievement. High school seniors from the Dominican Republic completed mathematics achievement tests and a questionnaire on mathematics attitudes. Results indicated that reciprocal relationships existed, suggesting that the reciprocal nature between…
Using Mathematics in Science: Working with Your Mathematics Department
ERIC Educational Resources Information Center
Lyon, Steve
2014-01-01
Changes to the mathematics and science curriculums are designed to increase rigour in mathematics, and place greater emphasis on mathematical content in science subjects at key stages 3, 4 and 5 (ages 11-18). One way to meet the growing challenge of providing increased emphasis on mathematics in the science curriculum is greater collaboration…
Applications of Secondary School Mathematics: Readings from the "Mathematics Teacher."
ERIC Educational Resources Information Center
Austin, Joe Dan, Ed.
This book provides applications for use in the secondary school mathematics curriculum by selecting related articles appearing in the "Mathematics Teacher" during the last 15 years. The articles are grouped into chapters that reflect the main secondary school mathematics courses and categorized by the highest level of mathematics needed for…
Promoting Critical Mathematics Literacy in Secondary Mathematics Teacher Education
ERIC Educational Resources Information Center
Fish, Michael Charles
2012-01-01
This study examines how critical mathematical literacy teachers conceptualize their practices and how those practices were demonstrated in the classroom. Practices were considered from an ontology of mathematics education, specific to critical mathematical literacy, in which classroom interactions question what it means to do mathematics as an…
Prospective Mathematics Teachers' Attitudes Towards Learning Mathematics with Technology
ERIC Educational Resources Information Center
Ipek, A. Sabri; Berigel, Muhammed; Albayrak, Mustafa
2007-01-01
Role of technology which is an important tool for new approaches in learning mathematics is rapidly increasing at focus point of learning mathematics with new designs. One of the biggest factors at learning and instructing technology based mathematic education is attitudes of mathematics teachers towards technology. At this study, attitudes of…
Elementary Mathematics Teachers' Perceptions and Lived Experiences on Mathematical Communication
ERIC Educational Resources Information Center
Kaya, Defne; Aydin, Hasan
2016-01-01
Mathematical thinking skills and meaningful mathematical understanding are among the goals of current mathematics education. There is a wide consensus among scholars about the purpose of developing mathematical understanding and higher order thinking skills in students. However, how to develop those skills in classroom settings is an area that…
Mathematical Modeling in Mathematics Education: Basic Concepts and Approaches
ERIC Educational Resources Information Center
Erbas, Ayhan Kürsat; Kertil, Mahmut; Çetinkaya, Bülent; Çakiroglu, Erdinç; Alacaci, Cengiz; Bas, Sinem
2014-01-01
Mathematical modeling and its role in mathematics education have been receiving increasing attention in Turkey, as in many other countries. The growing body of literature on this topic reveals a variety of approaches to mathematical modeling and related concepts, along with differing perspectives on the use of mathematical modeling in teaching and…
Alba, Christina; Bowers, M. Deane; Blumenthal, Dana; Hufbauer, Ruth A.
2014-01-01
Intra-specific variation in host-plant quality affects herbivore foraging decisions and, in turn, herbivore foraging decisions mediate plant fitness. In particular, variation in defenses against herbivores, both among and within plants, shapes herbivore behavior. If variation in defenses is genetically based, it can respond to natural selection by herbivores. We quantified intra-specific variation in iridoid glycosides, trichome length, and leaf strength in common mullein (Verbascum thapsus L, Scrophulariaceae) among maternal lines within a population and among leaves within plants, and related this variation to feeding preferences of a generalist herbivore, Trichopulsia ni Hübner. We found significant variation in all three defenses among maternal lines, with T. ni preferring plants with lower investment in chemical, but not mechanical, defense. Within plants, old leaves had lower levels of all defenses than young leaves, and were strongly preferred by T. ni. Caterpillars also preferred leaves with trichomes removed to leaves with trichomes intact. Differences among maternal lines indicate that phenotypic variation in defenses likely has a genetic basis. Furthermore, these results reveal that the feeding behaviors of T. ni map onto variation in plant defense in a predictable way. This work highlights the importance of variation in host-plant quality in driving interactions between plants and their herbivores. PMID:25127229
Campanella, Beatrice; Onor, Massimo; Ferrari, Carlo; D'Ulivo, Alessandro; Bramanti, Emilia
2014-09-16
In this work we have studied the derivatization of protein disulfide bonds with p-Hydroxymercurybenzoate (pHMB) in strong alkaline medium without any preliminary reduction. The reaction has been followed by the determination of the protein-pHMB complex using size exclusion chromatography coupled to a microwave/UV mercury oxidation system for the on-line oxidation of free and protein-complexed pHMB and atomic fluorescence spectrometry (SEC-CVG-AFS) detection. The reaction has been optimized by an experimental design using lysozyme as a model protein and applied to several thiolic proteins. The proposed method reports, for the first time, that it is possible to label 75-100% cysteines of proteins and, thus, to determine thiolic proteins without the need of any reducing step to obtain reduced SH groups before mercury labelling. We obtained a detection limit of 100 nmol L(-1) based on a signal-to-noise ratio of 3 for unbound and complexed pHMB, corresponding to a detection limit of proteins ranged between 3 and 360 nmol L(-1), depending on the number of cysteines in the protein sequence.
Modern Chemical Technology, Volume 1.
ERIC Educational Resources Information Center
Pecsok, Robert L.; Chapman, Kenneth
This volume is the first in a series of the ACS "Modern Chemical Technology" (ChemTeC) curriculum which is to prepare chemical technicians. The chapters concentrate on gas chromatography, tests for purity, properties of gases, and gas measurements. Included is the appropriate content, exercises, laboratory activities, and all needed mathematics.…
Mathematical challenges from theoretical/computational chemistry
1995-12-31
The committee believes that this report has relevance and potentially valuable suggestions for a wide range of readers. Target audiences include: graduate departments in the mathematical and chemical sciences; federal and private agencies that fund research in the mathematical and chemical sciences; selected industrial and government research and development laboratories; developers of software and hardware for computational chemistry; and selected individual researchers. Chapter 2 of this report covers some history of computational chemistry for the nonspecialist, while Chapter 3 illustrates the fruits of some past successful cross-fertilization between mathematical scientists and computational/theoretical chemists. In Chapter 4 the committee has assembled a representative, but not exhaustive, survey of research opportunities. Most of these are descriptions of important open problems in computational/theoretical chemistry that could gain much from the efforts of innovative mathematical scientists, written so as to be accessible introductions to the nonspecialist. Chapter 5 is an assessment, necessarily subjective, of cultural differences that must be overcome if collaborative work is to be encouraged between the mathematical and the chemical communities. Finally, the report ends with a brief list of conclusions and recommendations that, if followed, could promote accelerated progress at this interface. Recognizing that bothersome language issues can inhibit prospects for collaborative research at the interface between distinctive disciplines, the committee has attempted throughout to maintain an accessible style, in part by using illustrative boxes, and has included at the end of the report a glossary of technical terms that may be familiar to only a subset of the target audiences listed above.
The logical status of thermodynamic proofs of mathematical theorems
NASA Astrophysics Data System (ADS)
Deakin, M. A. B.; Troup, G. J.
1981-06-01
The logical status of such thermodynamic proofs of mathematical theorems as Landsberg's derivation of the inequality of arithmetic and geometric means is considered. The status is not as absolute as the rigorous demonstration of a mathematical theorem. Many axiomatic accounts of thermodynamics use this inequality to reduce the number of physical assumptions required.
Can Peer Assisted Learning Be Effective in Undergraduate Mathematics?
ERIC Educational Resources Information Center
Duah, Francis; Croft, Tony; Inglis, Matthew
2014-01-01
We report the implementation and evaluation of a "peer assisted learning" (PAL) scheme designed to reduce the so-called "cooling off" phenomenon in undergraduate mathematics. "Cooling off" occurs when mathematics undergraduates lose motivation and interest in their studies, despite having previously actively chosen to…
Reaching All Students with Mathematics.
ERIC Educational Resources Information Center
Cuevas, Gilbert, Ed.; Driscoll, Mark, Ed.
The National Council of Teachers of Mathematics'"Curriculum and Evaluation Standards for School Mathematics" and "Professional Standards for Teaching Mathematics" reflect the belief that all students can learn a significant core of high-quality mathematics. Recognizing the magnitude of the task of reaching all students, this book was put together…
What Counts as Mathematical Discourse?
ERIC Educational Resources Information Center
Moschkovich, Judit
2003-01-01
In this paper I use situated and socio-cultural perspective (Gee, 1996 & 1999) to examine descriptions of mathematical discourse and an example of student talk in a mathematics classroom. Using this example, I discuss how the distinction between everyday and mathematical discourse can help or hinder us in hearing the mathematical content in…
A Mathematics Software Database Update.
ERIC Educational Resources Information Center
Cunningham, R. S.; Smith, David A.
1987-01-01
Contains an update of an earlier listing of software for mathematics instruction at the college level. Topics are: advanced mathematics, algebra, calculus, differential equations, discrete mathematics, equation solving, general mathematics, geometry, linear and matrix algebra, logic, statistics and probability, and trigonometry. (PK)
Perceptions of Mathematics and Gender
ERIC Educational Resources Information Center
Kloosterman, Peter; Tassel, Janet; Ponniah, Ann G.; Esses, N. Kathryn
2008-01-01
This study examined students' perceptions about gender and the subject of mathematics, as well as gender and mathematics learning. Secondary school students and pre-service elementary teachers were surveyed using the Mathematics as a Gendered Domain and Who and Mathematics instruments developed by Leder and Forgasz (Leder, 2001). The data indicate…
Mathematical Modeling: A Structured Process
ERIC Educational Resources Information Center
Anhalt, Cynthia Oropesa; Cortez, Ricardo
2015-01-01
Mathematical modeling, in which students use mathematics to explain or interpret physical, social, or scientific phenomena, is an essential component of the high school curriculum. The Common Core State Standards for Mathematics (CCSSM) classify modeling as a K-12 standard for mathematical practice and as a conceptual category for high school…
Truth & Beauty: Mathematics in Literature
ERIC Educational Resources Information Center
Cohen, Marion D.
2013-01-01
Today there are many categories of mathematics literature, including fiction and poetry. Mathematics fiction appears in such anthologies as "Fantasia Mathematica" (Fadiman 1958, 1997) and "The Mathematical Magpie" (Fadiman 1962, 1997). In addition, mathematics fiction is featured at http://kasmana.people.cofc.edu/MATHFICT.…
Semantic Processing of Mathematical Gestures
ERIC Educational Resources Information Center
Lim, Vanessa K.; Wilson, Anna J.; Hamm, Jeff P.; Phillips, Nicola; Iwabuchi, Sarina J.; Corballis, Michael C.; Arzarello, Ferdinando; Thomas, Michael O. J.
2009-01-01
Objective: To examine whether or not university mathematics students semantically process gestures depicting mathematical functions (mathematical gestures) similarly to the way they process action gestures and sentences. Semantic processing was indexed by the N400 effect. Results: The N400 effect elicited by words primed with mathematical gestures…
Zhang, Manchao; Taylor, Christopher E.; Piao, Longzhu; Datta, Jharna; Bruno, Paul A.; Bhave, Sanjay; Su, Tizhi; Lang, James C.; Xie, Xiujie; Teknos, Theodoros N.; Mapp, Anna K.; Pan, Quintin
2013-01-01
Epidermal growth factor receptor (EGFR) is elevated in over 90% of head and neck squamous cell carcinoma (HNSCC). However, a majority of HNSCC patients do not respond to anti-EGFR therapeutics. Insensitivity to EGFR inhibitors may be due to kinase-independent actions of EGFR and/or activation of Her2. Strategies to reduce EGFR and Her2 protein levels in concert may be an optimal approach to enhance the efficacy of current anti-EGFR molecules. In this study, knockdown of ESX decreased EGFR and Her2 promoter activity, expression, and levels. ESX was elevated in primary HNSCC tumors and associated with increased EGFR and Her2. Genetic ablation of ESX decreased EGFR and Her2 levels and enhanced the anti-proliferative effects of EGFR/Her2 tyrosine kinase inhibitors, lapatinib and afatinib. Biphenyl isoxazolidine, a novel small molecule ESX inhibitor, reduced EGFR and Her2 levels and potentiated the anti-proliferative efficacy of afatinib. Single-agent biphenyl isoxazolidine retarded the in vivo tumorigenicity of CAL27 cells. Importantly, the combination of biphenyl isoxazolidine and afatinib was significantly superior in vivo and resulted in a 100% response rate with a 94% reduction in tumor volume. Targeting EGFR/Her2 levels with an ESX inhibitor and EGFR/Her2 kinase activity with a TKI simultaneously is a highly active therapeutic approach to manage HNSCC. Our work provides evidence to support the further development of ESX inhibitors as an adjuvant to enhance the response rate of HNSCC patients to current anti-EGFR/Her2 therapeutics. PMID:23723125
Collective Surfing of Chemically Active Particles
NASA Astrophysics Data System (ADS)
Masoud, Hassan; Shelley, Michael J.
2014-03-01
We study theoretically the collective dynamics of immotile particles bound to a 2D surface atop a 3D fluid layer. These particles are chemically active and produce a chemical concentration field that creates surface-tension gradients along the surface. The resultant Marangoni stresses create flows that carry the particles, possibly concentrating them. For a 3D diffusion-dominated concentration field and Stokesian fluid we show that the surface dynamics of active particle density can be determined using nonlocal 2D surface operators. Remarkably, we also show that for both deep or shallow fluid layers this surface dynamics reduces to the 2D Keller-Segel model for the collective chemotactic aggregation of slime mold colonies. Mathematical analysis has established that the Keller-Segel model can yield finite-time, finite-mass concentration singularities. We show that such singular behavior occurs in our finite-depth system, and study the associated 3D flow structures.
Collective surfing of chemically active particles.
Masoud, Hassan; Shelley, Michael J
2014-03-28
We study theoretically the collective dynamics of immotile particles bound to a 2D surface atop a 3D fluid layer. These particles are chemically active and produce a chemical concentration field that creates surface-tension gradients along the surface. The resultant Marangoni stresses create flows that carry the particles, possibly concentrating them. For a 3D diffusion-dominated concentration field and Stokesian fluid we show that the surface dynamics of active particle density can be determined using nonlocal 2D surface operators. Remarkably, we also show that for both deep or shallow fluid layers this surface dynamics reduces to the 2D Keller-Segel model for the collective chemotactic aggregation of slime mold colonies. Mathematical analysis has established that the Keller-Segel model can yield finite-time, finite-mass concentration singularities. We show that such singular behavior occurs in our finite-depth system, and study the associated 3D flow structures. PMID:24724685
Simple optical computing device for chemical analysis
NASA Astrophysics Data System (ADS)
Soyemi, Olusola O.; Zhang, Lixia; Eastwood, DeLyle; Li, Hongli; Gemperline, Paul J.; Myrick, Michael L.
2001-05-01
Multivariate Optical Computing (MOC) devices have the potential of greatly simplifying as well as reducing the cost of applying the mathematics of multivariate regression to problems of chemical analysis in the real world. These devices utilize special optical interference coatings known as multivariate optical elements (MOEs) that are encoded with pre-determined spectroscopic patterns to selectively quantify a chemical species of interest in the presence of other interfering species. A T-format prototype of the first optical computing device is presented utilizing a multilayer MOE consisting of alternating layers of two metal oxide films (Nb2O5 and SiO2) on a BK-7 glass substrate. The device was tested by using it to quantify copper uroporphyrin in a quaternary mixture consisting of uroporphyrin (freebase), tin uroporphyrin, nickel uroporphyrin, and copper uroporphyrin. A standard error of prediction (SEP) of 0.86(mu) M was obtained for copper uroporphyrin.
Mathematical simulation of Earth system dynamics
NASA Astrophysics Data System (ADS)
Dymnikov, V. P.; Lykosov, V. N.; Volodin, E. M.
2015-05-01
The mathematical simulation of the Earth system, the dynamics of which depends on physical, chemical, biological, and other processes and which requires interdisciplinary approaches to studying this problem, is considered. The term "the Earth system" extends the concept "the climatic system," since additional geospheres (lithosphere, heliosphere, etc.) are taken into account and a wider range of physical, chemical, biological, and social interactions is described. The present-day level of climate modeling is discussed, and some data obtained at the Institute of Numerical Mathematics, Russian Academy of Sciences (INM RAS), are presented for this purpose. The prospects for further development of climate models toward the creation of the Earth system models based on a seamless approach, according to which a unified model is used to make short-term (several days) and long-term (climatic) prediction, are considered.
The Effect of Mathematics Research on Mathematics Majors' Mathematical Beliefs
ERIC Educational Resources Information Center
Goodson, Joshua E.
2012-01-01
This is a dissertation about the beliefs that mathematics majors have about mathematics and how their beliefs are affected by the introduction of mathematics research. The mathematics research presented to the students dealt with counting regular orbits of an action. Research has shown that the beliefs that teachers hold about mathematics…
ERIC Educational Resources Information Center
Dickerson, David S.; Doerr, Helen M.
2014-01-01
Proof serves many purposes in mathematics. In this qualitative study of 17 high school mathematics teachers, we found that these teachers perceived that two of the most important purposes for proof in school mathematics were (a) to enhance students' mathematical understanding and (b) to develop generalized thinking skills that were…
ERIC Educational Resources Information Center
Thorndike-Christ, Tracy
The relationship of attitudes toward mathematics to mathematics performance, gender, mathematics course-taking plans, and career interests were investigated. Students enrolled in public middle and high school mathematics courses (722 male, 794 female) served as subjects. The Fennema-Sherman Math Attitude scales were used to measure attitudes…
Gaber, David; Schlimm, Dirk
2015-01-01
Mathematics is a powerful tool for describing and developing our knowledge of the physical world. It informs our understanding of subjects as diverse as music, games, science, economics, communications protocols, and visual arts. Mathematical thinking has its roots in the adaptive behavior of living creatures: animals must employ judgments about quantities and magnitudes in the assessment of both threats (how many foes) and opportunities (how much food) in order to make effective decisions, and use geometric information in the environment for recognizing landmarks and navigating environments. Correspondingly, cognitive systems that are dedicated to the processing of distinctly mathematical information have developed. In particular, there is evidence that certain core systems for understanding different aspects of arithmetic as well as geometry are employed by humans and many other animals. They become active early in life and, particularly in the case of humans, develop through maturation. Although these core systems individually appear to be quite limited in application, in combination they allow for the recognition of mathematical properties and the formation of appropriate inferences based upon those properties. In this overview, the core systems, their roles, their limitations, and their interaction with external representations are discussed, as well as possibilities for how they can be employed together to allow us to reason about more complex mathematical domains. PMID:26263425
Perception determinants in learning mathematics
NASA Astrophysics Data System (ADS)
Mokhtar, Siti Fairus; Ali, Noor Rasidah; Rashid, Nurazlina Abdul
2015-05-01
This article described a statistical study of students' perception in mathematics. The objective of this study is to identify factors related to perception about learning mathematics among non mathematics' student. This study also determined the relationship between of these factors among non mathematics' student. 43 items questionnaires were distributed to one hundred students in UiTM Kedah who enrolled in the Business Mathematics course. These items were measured by using a semantic scale with the following anchors: 1 = strongly disagree to 7 = strongly agree. A factor analysis of respondents were identified into five factors that influencing the students' perception in mathematics. In my study, factors identified were attitude, interest, role of the teacher, role of peers and usefulness of mathematics that may relate to the perception about learning mathematics among non mathematics' student.
Mathematical Astronomy in India
NASA Astrophysics Data System (ADS)
Plofker, Kim
Astronomy in South Asia's Sanskrit tradition, apparently originating in simple calendric computations regulating the timing of ancient ritual practices, expanded over the course of two or three millennia to include detailed spherical models, an endless variety of astrological systems, and academic mathematics in general. Assimilating various technical models, methods, and genres from the astronomy of neighboring cultures, Indian astronomers created new forms that were in turn borrowed by their foreign counterparts. Always recognizably related to the main themes of Eurasian geocentric mathematical astronomy, Indian astral science nonetheless maintained its culturally distinct character until Keplerian heliocentrism and Newtonian mechanics replaced it in colonial South Asia's academic mainstream.
Mathematics in modern immunology
Castro, Mario; Lythe, Grant; Molina-París, Carmen; Ribeiro, Ruy M.
2016-01-01
Mathematical and statistical methods enable multidisciplinary approaches that catalyse discovery. Together with experimental methods, they identify key hypotheses, define measurable observables and reconcile disparate results. We collect a representative sample of studies in T-cell biology that illustrate the benefits of modelling–experimental collaborations and that have proven valuable or even groundbreaking. We conclude that it is possible to find excellent examples of synergy between mathematical modelling and experiment in immunology, which have brought significant insight that would not be available without these collaborations, but that much remains to be discovered. PMID:27051512
Mathematics in modern immunology.
Castro, Mario; Lythe, Grant; Molina-París, Carmen; Ribeiro, Ruy M
2016-04-01
Mathematical and statistical methods enable multidisciplinary approaches that catalyse discovery. Together with experimental methods, they identify key hypotheses, define measurable observables and reconcile disparate results. We collect a representative sample of studies in T-cell biology that illustrate the benefits of modelling-experimental collaborations and that have proven valuable or even groundbreaking. We conclude that it is possible to find excellent examples of synergy between mathematical modelling and experiment in immunology, which have brought significant insight that would not be available without these collaborations, but that much remains to be discovered.
Mathematical Modeling of Cellular Metabolism.
Berndt, Nikolaus; Holzhütter, Hermann-Georg
2016-01-01
Cellular metabolism basically consists of the conversion of chemical compounds taken up from the extracellular environment into energy (conserved in energy-rich bonds of organic phosphates) and a wide array of organic molecules serving as catalysts (enzymes), information carriers (nucleic acids), and building blocks for cellular structures such as membranes or ribosomes. Metabolic modeling aims at the construction of mathematical representations of the cellular metabolism that can be used to calculate the concentration of cellular molecules and the rates of their mutual chemical interconversion in response to varying external conditions as, for example, hormonal stimuli or supply of essential nutrients. Based on such calculations, it is possible to quantify complex cellular functions as cellular growth, detoxification of drugs and xenobiotic compounds or synthesis of exported molecules. Depending on the specific questions to metabolism addressed, the methodological expertise of the researcher, and available experimental information, different conceptual frameworks have been established, allowing the usage of computational methods to condense experimental information from various layers of organization into (self-) consistent models. Here, we briefly outline the main conceptual frameworks that are currently exploited in metabolism research. PMID:27557541
Mathematical Modeling of Cellular Metabolism.
Berndt, Nikolaus; Holzhütter, Hermann-Georg
2016-01-01
Cellular metabolism basically consists of the conversion of chemical compounds taken up from the extracellular environment into energy (conserved in energy-rich bonds of organic phosphates) and a wide array of organic molecules serving as catalysts (enzymes), information carriers (nucleic acids), and building blocks for cellular structures such as membranes or ribosomes. Metabolic modeling aims at the construction of mathematical representations of the cellular metabolism that can be used to calculate the concentration of cellular molecules and the rates of their mutual chemical interconversion in response to varying external conditions as, for example, hormonal stimuli or supply of essential nutrients. Based on such calculations, it is possible to quantify complex cellular functions as cellular growth, detoxification of drugs and xenobiotic compounds or synthesis of exported molecules. Depending on the specific questions to metabolism addressed, the methodological expertise of the researcher, and available experimental information, different conceptual frameworks have been established, allowing the usage of computational methods to condense experimental information from various layers of organization into (self-) consistent models. Here, we briefly outline the main conceptual frameworks that are currently exploited in metabolism research.
Elementary School Mathematics Priorities
ERIC Educational Resources Information Center
Wilson, W. Stephen
2009-01-01
This article first describes some of the basic skills and knowledge that a solid elementary school mathematics foundation requires. It then elaborates on several points germane to these practices. These are then followed with a discussion and conclude with final comments and suggestions for future research. The article sets out the five…
The Constructivist Mathematics Classroom
ERIC Educational Resources Information Center
Jones, Karrie; Jones, Jennifer L.; Vermette, Paul J.
2010-01-01
By examining how people learn, the educational theories of Dewey, Piaget, Vygotsky and Bruner can be synthesized to give this set of core Constructivist principles. Principles of effective mathematics teaching: (1) allows learning that is "active" and "reflective". Students are required to transfer key concepts to new situations; (2) allows…
ERIC Educational Resources Information Center
Noblitt, Bethany A.; Buckley, Brooke E.
2011-01-01
Teams, pit stops, clues, time limits, fast forwards, challenges, and prizes are all components of the CBS hit show "The Amazing Race." They were also elements of the Amazing Mathematical Race sponsored by the Math and Stats Club at Northern Kentucky University in April 2009. Held in recognition of Math Awareness Month, which is advocated by the…
Fostering Creativity Through Mathematics.
ERIC Educational Resources Information Center
Lichtenberg, Betty K., Ed.; Troutman, Andria P., Ed.
The 26 activities described in this volume deal with a wide variety of mathematical ideas. Most of the activities are appropriate for grades 6-9; many could be used with older or younger groups as well. All activities are described in detail; some descriptions include sample worksheets, and several provide suggestions for followup activities. The…
Mathematics in Vocational Education.
ERIC Educational Resources Information Center
Oregon State Univ., Corvallis. Vocational-Technical Education Dept.
This handbook was developed to help the vocational teacher aid students in solving mathematical problems in vocational education classes. Most of the examples in the handbook were derived from metal-working and industrial mechanics classes; however, the procedures explained through them will work in any vocational class. The handbook is divided…
Navajo Area Mathematics Guidelines.
ERIC Educational Resources Information Center
Bureau of Indian Affairs (Dept. of Interior), Window Rock, AZ.
Heavy emphasis is placed on development of understanding of arithmetic in this mathematics curriculum prepared specifically for Navajo children and intended for use in reservation schools. Materials are presented so that only when a given concept is understood are skills associated with it and a written format introduced. Learning activities…
Supporting Mathematical Thinking
ERIC Educational Resources Information Center
Houssart, Jenny; Roaf, Caroline; Watson, Anne
2005-01-01
This book looks at how practitioners have focused on the fully educational application of intellect to the problem of developing mathematical thinking among one's pupils. Each chapter demonstrates reflective minds at work, relying on close observation, willingness to understand the student's thinking processes and patient commitment to students…
ERIC Educational Resources Information Center
Portales Public Schools, NM.
This curriculum guide provides aid in organizing and planning for the mathematical needs of the individual classroom. It is recommended that: (1) each teacher study the entire curriculum to become familiar with the concepts that interlock and blend all the grades together, and (2) all students with average ability master 70% of the skills. The…
Exploratory Problems in Mathematics.
ERIC Educational Resources Information Center
Stevenson, Frederick W.
This book attempts to introduce students to the creative aspects of mathematics through exploratory problems. The introduction presents the criteria for the selection of the problems in the book. Criteria indicate that problems should: be immediately attractive, require data to be generated or gathered, appeal to students from junior high school…
Making Music with Mathematics.
ERIC Educational Resources Information Center
Fernandez, Maria L.
1999-01-01
Presents examples of students' work when they are engaged in problem solving and reasoning tasks as they determine how to fill bottles with water to create musical notes by blowing across the tops of the bottles, and as they create mathematical models that represent these notes. (ASK)
Mathematics as Problem Solving.
ERIC Educational Resources Information Center
Soifer, Alexander
This book contains about 200 problems. It is suggested that it be used by students, teachers or anyone interested in exploring mathematics. In addition to a general discussion on problem solving, there are problems concerned with number theory, algebra, geometry, and combinatorics. (PK)
ERIC Educational Resources Information Center
Clary, Joseph R.; Nery, Karen P.
This set of three modules was designed for use primarily to help teach and reinforce the basic mathematics skills in drafting classes. The modules are based on the needs of drafting students in beginning courses as determined by a survey of teachers across North Carolina. Each module consists of basic information and examples and problem sheets…
ERIC Educational Resources Information Center
Popelka, Susan R.
2011-01-01
Tiny prisms in reflective road signs and safety vests have interesting geometrical properties that can be discussed at any level of high school mathematics. At the beginning of the school year, the author teaches a unit on these reflective materials in her precalculus class so that students can review and strengthen their geometry and trigonometry…
Correlating Mathematics and Science
ERIC Educational Resources Information Center
Mireles, Selena Vasquez
2009-01-01
The change from students learning all subjects together in a one-room schoolhouse to learning in classes separated by subject and grade resulted in distinct disciplines such as social studies, mathematics, science, and English. What was lost was the unified, holistic curriculum that a one-room setting required. Since students move from…
Investigating Children's Mathematics Readiness
ERIC Educational Resources Information Center
Lee, Joohi; Autry, Mary Murray; Fox, Jill; Williams, Cynthia
2008-01-01
A sample of 244 children (average age: 61 months) and their parents from the Dallas and Fort Worth (DFW) metroplex area in Texas were surveyed to investigate children's mathematics readiness. This study was conducted as part of a project funded by a local child care council, composed of business, civic, and education leaders in the community. The…
ERIC Educational Resources Information Center
Battista, Michael T.
1993-01-01
Presents a series of 13 activities to explore the mathematics of baseball. Activities examine the numerical measures of player statistics and team standings and the geometry of baseball. Discusses the use of computer spreadsheets and LOGO computer simulations to study the concepts embodied in the activities. (MDH)
ERIC Educational Resources Information Center
Davis, Sue
2009-01-01
The Williams Review (Dept. for Children, Schools and Families, 2008) is significantly important to all early years and primary educationalists, including those who are involved in teaching mathematics to the next generation of primary school teachers. The report, compiled as a result of this review, sets out the ways that children in primary…
Symmetry in Mathematics Learning.
ERIC Educational Resources Information Center
Dreyfus, Tommy; Eisenberg, Theodore
1989-01-01
Discusses the creed in symmetry and the omnipresence of symmetrical relationships in mathematics and nature, discusses mathematicians' attraction toward looking for symmetrical relationships as an unstated problem-solving heuristic, and shows how symmetry can be used as a didactical tool. (Author/MKR)
Consumer Mathematics. Teaching Units.
ERIC Educational Resources Information Center
North Carolina State Dept. of Public Instruction, Raleigh.
GRADES OR AGES: Secondary school. SUBJECT MATTER: Consumer mathematics including--money management, transportation, probability, swindles and gyps, insurance, housing, taxes, consumer credit, banks, savings, and investments. ORGANIZATION AND PHYSICAL APPEARANCE: The guide is divided into ten parallel units, one for each of the above areas, which…
ERIC Educational Resources Information Center
Barger, Rita H.; Jarrah, Adeeb M.
2012-01-01
March 14 is special because it is Pi Day. Mathematics is celebrated on that day because the date, 3-14, replicates the first three digits of pi. Pi-related songs, websites, trivia facts, and more are at the fingertips of interested teachers and students. Less celebrated, but still fairly well known, is National Metric Day, which falls on October…
Mathematics Unipac. Computers.
ERIC Educational Resources Information Center
Parma City School District, OH.
Five activities are presented in this student workbook designed for exploration of a career in computers, and the mathematics related to that career. Included are activities on basic computer language, flow charts, and basic computer programming. Each activity includes the objective, materials needed, and information for completing the activity.…
ERIC Educational Resources Information Center
Whitin, Phyllis; Whitin, David J.
2011-01-01
The habit of looking for patterns, the skills to find them, and the expectation that patterns have explanations is an essential mathematical habit of mind for young children (Goldenberg, Shteingold, & Feurzeig 2003, 23). Work with patterns leads to the ability to form generalizations, the bedrock of algebraic thinking, and teachers must nurture…
Mathematical Intrusions in Literatures
ERIC Educational Resources Information Center
Modica, Erasmo
2011-01-01
This article describes an activity that can be carried out in one of the final classes of Italian secondary schools. The aim of the activity is to stimulate pupil curiosity, demonstrating that Mathematics is not a barren subject and allowing the students, according to an interdisciplinary point of view, to investigate some literary works and the…
Audiovisual Materials in Mathematics.
ERIC Educational Resources Information Center
Raab, Joseph A.
This pamphlet lists five thousand current, readily available audiovisual materials in mathematics. These are grouped under eighteen subject areas: Advanced Calculus, Algebra, Arithmetic, Business, Calculus, Charts, Computers, Geometry, Limits, Logarithms, Logic, Number Theory, Probability, Soild Geometry, Slide Rule, Statistics, Topology, and…
ERIC Educational Resources Information Center
Bogdany, Melvin
The curriculum guide offers a course of training in the fundamentals of mathematics as applied to baking. Problems specifically related to the baking trade are included to maintain a practical orientation. The course is designed to help the student develop proficiency in the basic computation of whole numbers, fractions, decimals, percentage,…
Formal Definitions in Mathematics
ERIC Educational Resources Information Center
Shield, Mal
2004-01-01
The definition is an important language form in the register of mathematics. Students need to understand the structure of a definition so that they can make sense of the definitions they encounter and so that they can construct their own definitions as part of organising their thoughts about the concepts they have explored. This article suggests…
New Technologies in Mathematics.
ERIC Educational Resources Information Center
Sarmiento, Jorge
An understanding of past technological advancements can help educators understand the influence of new technologies in education. Inventions such as the abacus, logarithms, the slide rule, the calculating machine, computers, and electronic calculators have all found their place in mathematics education. While new technologies can be very useful,…
Mathematics and Mobile Learning
ERIC Educational Resources Information Center
White, Tobin; Martin, Lee
2014-01-01
This paper argues for an approach to mobile learning that leverages students' informal digital practices as resources for designing mathematics classrooms activities. We briefly describe two exploratory designs along these lines, one featuring the use of photos taken by students outside class and the other centered on their recording and…
ERIC Educational Resources Information Center
Bureau of Naval Personnel, Washington, DC.
The second of three volumes of a mathematics training course for Navy personnel, this document contains material primarily found at the college level. Beginning with logarithms and trigonometry, the text moves into vectors and static equilibrium (physics). Coordinate geometry, conic sections, and the tangents, normals, and slopes of curves follow.…
Using and Applying Mathematics
ERIC Educational Resources Information Center
Knight, Rupert
2011-01-01
The Nobel prize winning physicist Richard Feynman (2007) famously enthused about "the pleasure of finding things out". In day-to-day classroom life, however, it is easy to lose and undervalue this pleasure in the process, as opposed to products, of mathematics. Finding things out involves a journey and is often where the learning takes place.…
Designing for Mathematical Abstraction
ERIC Educational Resources Information Center
Pratt, Dave; Noss, Richard
2010-01-01
Our focus is on the design of systems (pedagogical, technical, social) that encourage mathematical abstraction, a process we refer to as "designing for abstraction." In this paper, we draw on detailed design experiments from our research on children's understanding about chance and distribution to re-present this work as a case study in designing…
A Classroom Mathematics Utility.
ERIC Educational Resources Information Center
Williams, Michael
1984-01-01
Reviews CATUSPLOT, a mathematics utility aimed at high school algebra through college-level calculus. Basic program capabilities include plotting, tabulating, integrating, and locating of intersections of functions composed of combinations of polynomial, trigonometric, and exponential functions. Rated excellent on all areas examined…
Designing a Mathematics Curriculum
ERIC Educational Resources Information Center
Yee, Lee Peng
2010-01-01
A decade of PMRI saw the changes in the classroom in some of the primary schools in Indonesia. Based on observation, we can say that though the mathematics syllabus in Indonesia did not change, its curriculum has changed under the movement of PMRI. In this article, we put in writing some of the experience gained through the involvement in…
Storytelling + Origami = Storigami Mathematics
ERIC Educational Resources Information Center
Mastin, Marla
2007-01-01
This article presents a way to engage students in mathematics learning by using the innovative instructional method of storigami. The author shares reactions from teachers who have used her storigami techniques in their classes and provides an example of storigami using the Norwegian fable "The Dog and the Mountain." (Contains 6 figures.)
ERIC Educational Resources Information Center
Bruun, Faye; Diaz, Joan M.; Dykes, Valerie J.
2015-01-01
Students may excel in computation, but their ability to apply their skills will suffer if they do not understand the math vocabulary used in instructions and story problems. This action research project examines two methods for strengthening students' ability to communicate mathematically: (1) Journal writing and peer discussion; and (2) The…
ERIC Educational Resources Information Center
Thornton, Steve
2000-01-01
Describes the most enduring link between Napoleon and mathematics as the geometric result known as Napoleon's Theorem, which states that if equilateral triangles are drawn on the three sides of any triangle, the line segments joining the centers of these equilateral triangles will themselves form an equilateral triangle. (ASK)
Learning Mathematics through Games
ERIC Educational Resources Information Center
Gough, John
2015-01-01
When considering the use of games for teaching mathematics, educators should distinguish between an "activity" and a "game". Gough (1999) states that "A 'game' needs to have two or more players, who take turns, each competing to achieve a 'winning' situation of some kind, each able to exercise some choice about how to move…
Teaching Vocational Mathematics.
ERIC Educational Resources Information Center
Thiering, Jeannette; And Others
This Australian document is a guide to teaching mathematics as it relates to specific work situations. After a brief introduction, chapter 1 looks at problem solving, advises teachers to lower the reading level and thus raise the understandability of written math problems, and describes a four-step problem-solving process. Chapter 2 outlines a…
Comprehension Tests in Mathematics.
ERIC Educational Resources Information Center
Conradie, Jurie; Frith, John
2000-01-01
Presents an alternative way for testing a student's understanding of theory in a tertiary mathematics course. Provides two sample questions and discusses the advantages and disadvantages of the method. Argues that the method is an acceptable and flexible means of testing students and can be adapted to use in other contexts as well. (Author/ASK)
Celebrate Mathematical Curiosity
ERIC Educational Resources Information Center
Redford, Christine
2011-01-01
Children's mathematical questions are often based in real-world experiences, as they instinctively make connections to the world around them. In teaching math methods courses, this author recently started to emphasize the importance of fostering curiosity in, and activating the thinking of, the students. In this article, she describes how to tap…
ERIC Educational Resources Information Center
Leutzinger, Larry, Ed.
This book contains articles that help to further the process of reform in the middle grades, recognizing that the knowledge acquired during these years greatly affects how well the secondary school curriculum will attain its goals. Critical issues facing middle grade classes in particular and all mathematics classrooms in general are discussed.…
Mathematics Through Paper Folding.
ERIC Educational Resources Information Center
Olson, Alton T.
This booklet is a revised edition of Donovan Johnson's "Paper Folding for the Mathematics Class" (ED 077 711). It begins with directions for folding basic constructions such as as a straight line, the line perpendicular to a given line passing through a given point, and the bisector of an angle. Subsequent chapters cover concepts related to…
ERIC Educational Resources Information Center
Zack, Laurie; Fuselier, Jenny; Graham-Squire, Adam; Lamb, Ron; O'Hara, Karen
2015-01-01
Our study compared a flipped class with a standard lecture class in four introductory courses: finite mathematics, precalculus, business calculus, and calculus 1. The flipped sections watched video lectures outside of class and spent time in class actively working on problems. The traditional sections had lectures in class and did homework outside…
ERIC Educational Resources Information Center
Cain, David
2007-01-01
In this article, the author looks at ways of creating conditions to bring about learning. If one is to "arrange conditions to bring about learning," one needs written guidance and support systems. Two books that discusses how to arrange these conditions are: "Thinking Mathematically" by John Mason with Leone Burton and Kaye Stacey and "Starting…
Urban Mathematics Teacher Retention
ERIC Educational Resources Information Center
Hamdan, Kamal
2010-01-01
Mathematics teachers are both more difficult to attract and more difficult to retain than social sciences teachers. This fact is not unique to the United States; it is reported as being a problem in Europe as well (Howson, 2002). In the United States, however, the problem is particularly preoccupying. Because of the chronic teacher shortages and…
NEEDLE TRADES, MATHEMATICS - I.
ERIC Educational Resources Information Center
COLICCHIO, ANTOINETTE J.
THE NEEDLE TRADES INDUSTRY CONSISTS OF THREE TYPES OF ESTABLISHMENTS -- THE REGULAR MANUFACTURERS, THE APPAREL JOBBERS, AND THE CONTRACTORS. THE FUNCTIONS INCLUDED COVER A WIDE SCOPE FROM BUYING OF RAW MATERIAL TO SELLING OF THE FINISHED APPAREL. THE PURPOSE OF THIS STUDY GUIDE IS TO FURNISH BASIC KNOWLEDGE IN MATHEMATICS AND DEVELOP SKILL IN…
COMMERCIAL FOODS, MATHEMATICS - I.
ERIC Educational Resources Information Center
DORNFIELD, BLANCHE E.
THE UNDERSTANDING AND MASTERY OF FUNDAMENTAL MATHEMATICS IS A NECESSARY PART OF COMMERCIAL FOODS WORK. THIS STUDENT HANDBOOK WAS DESIGNED TO ACCOMPANY A COMMERCIAL FOODS COURSE AT THE HIGH SCHOOL LEVEL FOR STUDENTS WITH APPROPRIATE APTITUDES AND COMMERCIAL FOOD SERVICE GOALS. THE MATERIAL, TESTED IN VARIOUS INTERESTED CLASSROOMS, WAS PREPARED BY…
Computers in Fundamental Mathematics.
ERIC Educational Resources Information Center
New York City Board of Education, Brooklyn, NY. Div. of Computer Information Services.
This manual provides a resource for mathematics teachers who wish to take advantage of the extensive library of computer software materials available to expand and strengthen classroom instruction. Classroom management procedures, software duplication guidelines, copying procedures of diskettes for MS DOS and Apple II computers, and methods for…
Cort, John R.; Swenson, Michael; Magnuson, Timothy S.
2011-03-04
We report the 1H, 13C, and 15N chemical shift assignments of both oxidized and reduced forms of an abundant periplasmic c-type cytochrome, designated ApcA, from the acidophilic gram-negative facultatively anaerobic metal-reducing alpha-proteobacterium Acidiphilium cryptum. These resonance assignments prove that ApcA is a monoheme cytochrome c2 and the product of the Acry_2099 gene. An absence of resonance peaks in the NMR spectra for the 21 N-terminal residues suggests that a predicted N-terminal signal sequence is cleaved. We also describe the preparation and purification of the protein in labeled form from laboratory cultures of A. cryptum growing on 13C- and 15N- labeled substrates.
NASA Astrophysics Data System (ADS)
Flowers, Reagan D.
The primary purpose of this study was to investigate how a management service organization can assist schools with reducing the achievement gap between minority and non-minority students in science, technology, engineering, and mathematics (STEM) during the after-school hours. Developing a strategic plan through creating a program that provides support services for the implementation of hands-on activities in STEM for children during the after-school hours was central to this purpose. This Project Demonstrating Excellence (PDE), a social action project, also presents historical and current after-school program developments in the nation. The study is quantitative and qualitative in nature. Surveys were utilized to quantitatively capture the opinions of participants in the social action project on three specific education related issues: (1) disparity in academic motivation of students to participate in after-school STEM enrichment programs; (2) whether teachers and school administrators saw a need for STEM after-school enrichment; and (3) developing STEM after-school programs that were centered on problem-solving and higher-order thinking skills to develop students' interest in STEM careers. The sample consisted of 50 participants comprised of students, teachers, and administrators. The focus groups and interviews provided the qualitative data for the study. The qualitative sample consisted of 14 participants comprised of students, parents and teachers, administrators, an education consultant, and a corporate sponsor. The empirical data obtained from the study survey, focus groups, and interviews provided a comprehensive profile on the current views and future expectations of STEM after-school enrichment, student and school needs, and community partnerships with STEM companies. Results of the study and review of the implementation of the social action project, C-STEM (communication, science, technology, engineering, and mathematics) Teacher and Student Support
Middle School Mathematics Students' Perspectives on the Study of Mathematics
ERIC Educational Resources Information Center
Vaughn, Christy H.
2012-01-01
This qualitative study addressed the perceptions toward the study of mathematics by middle school students who had formerly been in a remedial mathematics program. The purpose of the study was to explore the past experiences of nine students in order to determine what is needed for them to feel successful in mathematics. The conceptual framework…
Between the Academic Mathematics and the Mathematics Education Worlds.
ERIC Educational Resources Information Center
Moreira, Candida Queiroz
1997-01-01
Investigated stresses confronted by Portuguese secondary mathematics teachers during the first semester in a master's course, Perspectives on Mathematics Education, noting how they negatively affected teachers' self-confidence and morale and discussing fundamental issues teachers addressed in bridging the academic mathematics and mathematics…
Mathematics Teacher Candidates' Metaphors about the Concept of "Mathematics"
ERIC Educational Resources Information Center
Erdogan, Ahmet; Yazlik, Derya Ozlem; Erdik, Cengiz
2014-01-01
The main purpose of this study was to research mathematics teacher candidates' perceptions about the concept of "mathematics" through the use of metaphors. The research is conducted during 2012-2013 academic year, on a group of 111 mathematics teacher candidates at the Education Faculty of a University in Turkey. To collect the research…
History of Modern Applied Mathematics in Mathematics Education
ERIC Educational Resources Information Center
Jankvist, Uffe Thomas
2009-01-01
This article discusses the integration of history of modern applied mathematics in mathematics education as well as the possible teaching and learning benefits of introducing a newer history of mathematics over an old(er) one--something that seems to be done most often when integrating history. Three cases of the history of modern applied…
Mathematical Models of Elementary Mathematics Learning and Performance. Final Report.
ERIC Educational Resources Information Center
Suppes, Patrick
This project was concerned with the development of mathematical models of elementary mathematics learning and performance. Probabilistic finite automata and register machines with a finite number of registers were developed as models and extensively tested with data arising from the elementary-mathematics strand curriculum developed by the…
Mathematics Teachers' Ideas about Mathematical Models: A Diverse Landscape
ERIC Educational Resources Information Center
Bautista, Alfredo; Wilkerson-Jerde, Michelle H.; Tobin, Roger G.; Brizuela, Bárbara M.
2014-01-01
This paper describes the ideas that mathematics teachers (grades 5-9) have regarding mathematical models of real-world phenomena, and explores how teachers' ideas differ depending on their educational background. Participants were 56 United States in-service mathematics teachers. We analyzed teachers' written responses to three open-ended…
Multicultural Mathematics: A More Inclusive Mathematics. ERIC Digest.
ERIC Educational Resources Information Center
Strutchens, Marilyn
Until recently there have not been many links to students' culture in the mathematics classroom. This may be one of the major barriers to achievement of many groups historically underrepresented in mathematics, for these students may see mathematics as a subject that has very little meaning or value for their current or future lives. This digest…
Racial Differences in Mathematics Test Scores for Advanced Mathematics Students
ERIC Educational Resources Information Center
Minor, Elizabeth Covay
2016-01-01
Research on achievement gaps has found that achievement gaps are larger for students who take advanced mathematics courses compared to students who do not. Focusing on the advanced mathematics student achievement gap, this study found that African American advanced mathematics students have significantly lower test scores and are less likely to be…
Problems with Fallibilism as a Philosophy of Mathematics Education
NASA Astrophysics Data System (ADS)
Rowlands, Stuart; Graham, Ted; Berry, John
2011-07-01
Much reference has been made to Paul Ernest's `philosophy of mathematics education' to legitimise a strong fallibilist trend in mathematics education. This article presents the argument that: (1) This philosophy makes unwarranted assumptions that have been taken as `given'. For example, that `absolutist' or `Platonist' views of mathematics necessarily imply the transmission model of teaching mathematics. (2) The very basis of this philosophy contains a contradiction: that mathematics cannot be separated from its social origins, yet mathematics has a logical necessity that is independent of its origin. (3) This philosophy downplays mathematics as a formal, academic system of knowledge in the attempt to promote a child-centred pedagogy or the mathematics of social practices. (4) Ernest's attempt to semiotically reduce proof to calculation is flawed. This article explores what is meant by fallibilism in relation to the views of many educationalists who appear not to like mathematics as a formal, academic body of knowledge and draws out the educational implications of these views.
Integrating Mathematics and Social Issues
ERIC Educational Resources Information Center
Harrell, Gregory K.
2007-01-01
This article illustrates how to integrate mathematics with social issues. Social issues discussed in the newspaper provide a rich context for connecting mathematical activities to the real world. The sample activities focus on measurement concepts. (Contains 2 figures.)
Integrating Mathematics and Composition Instruction.
ERIC Educational Resources Information Center
Kirtland, Joseph; Hoh, Pau-San
2002-01-01
Describes the development of an integrated approach for teaching mathematics and writing to freshmen. The goals are to strengthen mathematical skills, develop writing competencies, and foster interdisciplinary awareness. (Author/MM)
Overview of Mathematical Social Sciences.
ERIC Educational Resources Information Center
Kim, K. H.; And Others
1992-01-01
Provides a survey of models that use mathematics in a variety of fields of social science. Discusses specifically mathematical applications in demography, economics, management, political science, psychology, sociology, and other areas. Proposes four unsolved problems. (20 references) (MDH)
Ambiguity and Paradox in Mathematics
ERIC Educational Resources Information Center
Byers, William
2007-01-01
Many people believe that mathematics provides a model of what thinking is, or should be. They imagine that mathematical thinking always proceeds in a logically rigorous, step-by-step fashion from one truth to another, like a formal proof or a computer program. In fact, insights in mathematics -- whether they are the scholar's breakthroughs or the…
New Jersey Mathematics Curriculum Framework.
ERIC Educational Resources Information Center
Rosenstein, Joseph G.; And Others
The New Jersey Mathematics Curriculum Framework is based on the "Mathematics Standards" adopted by the New Jersey State Board of Education on May 1, 1996, and is intended to provide guidance to teachers, administrators, and districts that will help them translate a vision of exemplary mathematics education into reality. It includes information and…
Ethical Dimensions of Mathematics Education
ERIC Educational Resources Information Center
Boylan, Mark
2016-01-01
The relationships between mathematics, mathematics education and issues such as social justice and equity have been addressed by the sociopolitical tradition in mathematics education. Others have introduced explicit discussion of ethics, advocating for its centrality. However, this is an area that is still under developed. There is a need for an…
Infants and Toddlers Exploring Mathematics.
ERIC Educational Resources Information Center
Geist, Eugene
2003-01-01
Offers examples of what infants and toddlers might do in early childhood settings, how these behaviors are related to mathematics, and what teachers can do to encourage the natural mathematical interests of this age group. Asserts that teachers' interactions with children are vitally important to children's understanding of early mathematics. (KB)
The Emergence of Mathematical Structures
ERIC Educational Resources Information Center
Hegedus, Stephen John; Moreno-Armella, Luis
2011-01-01
We present epistemological ruptures that have occurred in mathematical history and in the transformation of using technology in mathematics education in the twenty-first century. We describe how such changes establish a new form of digital semiotics that challenges learning paradigms and mathematical inquiry for learners today. We focus on drawing…
Students' Mathematical Noticing
ERIC Educational Resources Information Center
Lobato, Joanne; Hohensee, Charles; Rhodehamel, Bohdan
2013-01-01
Even in simple mathematical situations, there is an array of different mathematical features that students can attend to or notice. What students notice mathematically has consequences for their subsequent reasoning. By adapting work from both cognitive science and applied linguistics anthropology, we present a focusing framework, which treats…
ERIC Educational Resources Information Center
Sriraman, Bharath, Ed.
2012-01-01
The interaction of the history of mathematics and mathematics education has long been construed as an esoteric area of inquiry. Much of the research done in this realm has been under the auspices of the history and pedagogy of mathematics group. However there is little systematization or consolidation of the existing literature aimed at…
A Primer for Mathematical Modeling
ERIC Educational Resources Information Center
Sole, Marla
2013-01-01
With the implementation of the National Council of Teachers of Mathematics recommendations and the adoption of the Common Core State Standards for Mathematics, modeling has moved to the forefront of K-12 education. Modeling activities not only reinforce purposeful problem-solving skills, they also connect the mathematics students learn in school…
Resisting Reductionism in Mathematics Pedagogy
ERIC Educational Resources Information Center
Foster, Colin
2013-01-01
Although breaking down a mathematical problem into smaller parts can often be an effective solution strategy, when the same reductionist approach is applied to mathematics pedagogy the effects are far from beneficial for students. Mathematics pedagogy in UK schools is gaining an increasingly reductionist flavour, as seen in an excessive focus on…
Learning to Write about Mathematics
ERIC Educational Resources Information Center
Parker, Renee; Breyfogle, M. Lynn
2011-01-01
Beginning in third grade, Pennsylvania students are required to take the Pennsylvania State Standardized Assessment (PSSA), which presents multiple-choice mathematics questions and open-ended mathematics problems. Consistent with the Communication Standard of the National Council of Teachers of Mathematics, while solving the open-ended problems,…
The Psychological Foundations of Mathematics.
ERIC Educational Resources Information Center
Suppes, Patrick
1967-01-01
This paper outlines problems which are central to the psychological foundations of mathematics. Discussed are the relations that exist between psychological and classical foundations of mathematics. It is shown how the inadequacies of current learning theories which account for complex mathematics learning may be made explicit for appropriate…
Toddlers' Opportunities to Learn Mathematics
ERIC Educational Resources Information Center
Bjorklund, Camilla
2008-01-01
Mathematical knowledge has developed from human activities through thousands of years and is bound to the world and cultures that men and women experience. One can say that mathematics is rooted in humans' everyday life, an environment where people reach agreement regarding principles in mathematics. Through interaction with worldly phenomena and…
Mathematics in the Early Years.
ERIC Educational Resources Information Center
Copley, Juanita V., Ed.
Noting that young children are capable of surprisingly complex forms of mathematical thinking and learning, this book presents a collection of articles depicting children discovering mathematical ideas, teachers fostering students' informal mathematical knowledge, adults asking questions and listening to answers, and researchers examining…
Investigating Teachers' Images of Mathematics
ERIC Educational Resources Information Center
Sterenberg, Gladys
2008-01-01
Research suggests that understanding new images of mathematics is very challenging and can contribute to teacher resistance. An explicit exploration of personal views of mathematics may be necessary for pedagogical change. One possible way for exploring these images is through mathematical metaphors. As metaphors focus on similarities, they can be…
The Nature of Mathematics Anxiety.
ERIC Educational Resources Information Center
Cemen, Pamala Byrd
This paper attempts to generate a comprehensive description of the nature of mathematics anxiety through a synthesis of: (1) the general and test anxiety literatures applied to mathematics anxiety; (2) the mathematics anxiety literature, and (3) case studies developed through in-depth interviews. The indepth interviews were conducted with seven…
Creativity: The Essence of Mathematics
ERIC Educational Resources Information Center
Mann, Eric L.
2006-01-01
For the gifted mathematics student, early mastery of concepts and skills in the mathematics curriculum usually results in getting more of the same work and/or moving through the curriculum at a faster pace. Testing, grades, and pacing overshadow the essential role of creativity involved in doing mathematics. Talent development requires creative…
Unlocking Mathematics Teaching. Second Edition
ERIC Educational Resources Information Center
Koshy, Valsa, Ed.; Murray, Jean, Ed.
2011-01-01
Now in a fully updated second edition, "Unlocking Mathematics Teaching" is a comprehensive guide to teaching mathematics in the primary school. Combining theory and practice, selected experts outline the current context of mathematics education. They suggest strategies, activities and examples to help develop readers understanding and confidence…
Assessment and Learning of Mathematics.
ERIC Educational Resources Information Center
Leder, Gilah C., Ed.
This book addresses the link between student learning of mathematics, the teaching method adopted in the mathematics classroom, and the assessment procedures used to determine and measure student knowledge. Fifteen chapters address issues that include a review of different models of mathematics learning and assessment practices, three contrasting…
Mathematics Unit Plans. PACE '94.
ERIC Educational Resources Information Center
Wiles, Clyde A., Ed.; Schoon, Kenneth J., Ed.
This booklet contains mathematics unit plans for Algebra 1, Geometry, Math for Technology, Mathematical Problem Solving, and Pre-Algebra developed by PACE (Promoting Academic Excellence In Mathematics, Science & Technology for Workers of the 21st Century). Each unit plan contains suggested timing, objectives, skills to be acquired, workplace…
Professional Development of Mathematics Teachers.
ERIC Educational Resources Information Center
Wu, Hung-Hsi
1999-01-01
This essay discusses inservice professional development and suggests that any improvement in mathematics education must begin with teachers already in the classroom. It includes three examples of mathematical presentations in professional development made in Californian schools relating to discrete mathematics, connections, and technology. (MM)
STEM Gives Meaning to Mathematics
ERIC Educational Resources Information Center
Hefty, Lukas J.
2015-01-01
The National Council of Teachers of Mathematics' (NCTM's) "Principles and Standards for School Mathematics" (2000) outlines fi ve Process Standards that are essential for developing deep understanding of mathematics: (1) Problem Solving; (2) Reasoning and Proof; (3) Communication; (4) Connections; and (5) Representation. The Common Core…
Mathematical Giftedness: A Creative Scenario
ERIC Educational Resources Information Center
Sharma, Yogesh
2013-01-01
Identification and development of giftedness is a major task of mathematics teachers worldwide. An early identification of gifted children in mathematics can have a number of benefits, like, providing opportunities for the nourishment of their talent, saving them from burnout, and proper utilisation of mathematical talent in future. As creativity…
Putting Mathematical Tasks into Context
ERIC Educational Resources Information Center
Nagle, Courtney R.; Styers, Jodie L.
2015-01-01
Although many factors affect students' mathematical activity during a lesson, the teacher's selection and implementation of tasks is arguably the most influential in determining the level of student engagement. Mathematical tasks are intended to focus students' attention on a particular mathematical concept and it is the careful developing and…
Mathematical Modelling in European Education
ERIC Educational Resources Information Center
Ferri, Rita Borromeo
2013-01-01
Teaching and learning of mathematical modelling has become a key competence within school curricula and educational standards in many countries of the world. The term mathematical modelling, its meaning, and how it can be implemented in mathematics lessons have been intensively discussed during several Conferences of the European Society for…