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Sample records for matrix factorisation models

  1. Bayesian Inference for Nonnegative Matrix Factorisation Models

    PubMed Central

    Cemgil, Ali Taylan

    2009-01-01

    We describe nonnegative matrix factorisation (NMF) with a Kullback-Leibler (KL) error measure in a statistical framework, with a hierarchical generative model consisting of an observation and a prior component. Omitting the prior leads to the standard KL-NMF algorithms as special cases, where maximum likelihood parameter estimation is carried out via the Expectation-Maximisation (EM) algorithm. Starting from this view, we develop full Bayesian inference via variational Bayes or Monte Carlo. Our construction retains conjugacy and enables us to develop more powerful models while retaining attractive features of standard NMF such as monotonic convergence and easy implementation. We illustrate our approach on model order selection and image reconstruction. PMID:19536273

  2. Algorithmic deformation of matrix factorisations

    NASA Astrophysics Data System (ADS)

    Carqueville, Nils; Dowdy, Laura; Recknagel, Andreas

    2012-04-01

    Branes and defects in topological Landau-Ginzburg models are described by matrix factorisations. We revisit the problem of deforming them and discuss various deformation methods as well as their relations. We have implemented these algorithms and apply them to several examples. Apart from explicit results in concrete cases, this leads to a novel way to generate new matrix factorisations via nilpotent substitutions, and to criteria whether boundary obstructions can be lifted by bulk deformations.

  3. An integrated PM2.5 source apportionment study: Positive Matrix Factorisation vs. the chemical transport model CAMx

    NASA Astrophysics Data System (ADS)

    Bove, M. C.; Brotto, P.; Cassola, F.; Cuccia, E.; Massabò, D.; Mazzino, A.; Piazzalunga, A.; Prati, P.

    2014-09-01

    Receptor and Chemical Transport Models are commonly used tools in source apportionment studies, even if different expertise is required. We describe an experiment using both approaches to apportion the PM2.5 (i.e., particulate matter with aerodynamic diameters below 2.5 μm) sources in the city of Genoa (Italy). A sampling campaign was carried out to collect PM2.5 samples daily for approximately six month during 2011 in three sites. The subsequent compositional analyses included the speciation of elements, major ions and both organic and elemental carbon; these data produced a large database for receptor modelling through Positive Matrix Factorisation (PMF). In the same period, a meteorological and air quality modelling system was implemented based on the mesoscale numerical weather prediction model WRF and the chemical transport model CAMx to obtain meteorological and pollutant concentrations up to a resolution of 1.1 km. The source apportionment was evaluated by CAMx over the same period that was used for the monitoring campaign using the Particulate Source Apportionment Technology tool. Even if the source categorisations were changed (i.e., groups of time-correlated compounds in PMF vs. activity categories in CAMx), the PM2.5 source apportionment by PMF and CAMx produced comparable results. The different information provided by the two approaches (e.g., real-world factor profile by PMF and apportionment of a secondary aerosol by CAMx) was used jointly to elucidate the composition and origin of PM2.5 and to develop a more general methodology. When studying the primary and secondary components of PM, the main anthropogenic sources in the area were road transportation, energy production/industry and maritime emissions, accounting for 40%-50%, 20%-30% and 10%-15%, of PM2.5, respectively.

  4. Tracking Time Evolution of Collective Attention Clusters in Twitter: Time Evolving Nonnegative Matrix Factorisation.

    PubMed

    Saito, Shota; Hirata, Yoshito; Sasahara, Kazutoshi; Suzuki, Hideyuki

    2015-01-01

    Micro-blogging services, such as Twitter, offer opportunities to analyse user behaviour. Discovering and distinguishing behavioural patterns in micro-blogging services is valuable. However, it is difficult and challenging to distinguish users, and to track the temporal development of collective attention within distinct user groups in Twitter. In this paper, we formulate this problem as tracking matrices decomposed by Nonnegative Matrix Factorisation for time-sequential matrix data, and propose a novel extension of Nonnegative Matrix Factorisation, which we refer to as Time Evolving Nonnegative Matrix Factorisation (TENMF). In our method, we describe users and words posted in some time interval by a matrix, and use several matrices as time-sequential data. Subsequently, we apply Time Evolving Nonnegative Matrix Factorisation to these time-sequential matrices. TENMF can decompose time-sequential matrices, and can track the connection among decomposed matrices, whereas previous NMF decomposes a matrix into two lower dimension matrices arbitrarily, which might lose the time-sequential connection. Our proposed method has an adequately good performance on artificial data. Moreover, we present several results and insights from experiments using real data from Twitter.

  5. Tracking Time Evolution of Collective Attention Clusters in Twitter: Time Evolving Nonnegative Matrix Factorisation

    PubMed Central

    Saito, Shota; Hirata, Yoshito; Sasahara, Kazutoshi; Suzuki, Hideyuki

    2015-01-01

    Micro-blogging services, such as Twitter, offer opportunities to analyse user behaviour. Discovering and distinguishing behavioural patterns in micro-blogging services is valuable. However, it is difficult and challenging to distinguish users, and to track the temporal development of collective attention within distinct user groups in Twitter. In this paper, we formulate this problem as tracking matrices decomposed by Nonnegative Matrix Factorisation for time-sequential matrix data, and propose a novel extension of Nonnegative Matrix Factorisation, which we refer to as Time Evolving Nonnegative Matrix Factorisation (TENMF). In our method, we describe users and words posted in some time interval by a matrix, and use several matrices as time-sequential data. Subsequently, we apply Time Evolving Nonnegative Matrix Factorisation to these time-sequential matrices. TENMF can decompose time-sequential matrices, and can track the connection among decomposed matrices, whereas previous NMF decomposes a matrix into two lower dimension matrices arbitrarily, which might lose the time-sequential connection. Our proposed method has an adequately good performance on artificial data. Moreover, we present several results and insights from experiments using real data from Twitter. PMID:26417999

  6. Extended Nonnegative Tensor Factorisation Models for Musical Sound Source Separation

    PubMed Central

    FitzGerald, Derry; Cranitch, Matt; Coyle, Eugene

    2008-01-01

    Recently, shift-invariant tensor factorisation algorithms have been proposed for the purposes of sound source separation of pitched musical instruments. However, in practice, existing algorithms require the use of log-frequency spectrograms to allow shift invariance in frequency which causes problems when attempting to resynthesise the separated sources. Further, it is difficult to impose harmonicity constraints on the recovered basis functions. This paper proposes a new additive synthesis-based approach which allows the use of linear-frequency spectrograms as well as imposing strict harmonic constraints, resulting in an improved model. Further, these additional constraints allow the addition of a source filter model to the factorisation framework, and an extended model which is capable of separating mixtures of pitched and percussive instruments simultaneously. PMID:18551178

  7. A Novel Sky-Subtraction Method Based on Non-negative Matrix Factorisation with Sparsity for Multi-object Fibre Spectroscopy

    NASA Astrophysics Data System (ADS)

    Zhang, Bo; Zhang, Long; Ye, Zhongfu

    2016-12-01

    A novel sky-subtraction method based on non-negative matrix factorisation with sparsity is proposed in this paper. The proposed non-negative matrix factorisation with sparsity method is redesigned for sky-subtraction considering the characteristics of the skylights. It has two constraint terms, one for sparsity and the other for homogeneity. Different from the standard sky-subtraction techniques, such as the B-spline curve fitting methods and the Principal Components Analysis approaches, sky-subtraction based on non-negative matrix factorisation with sparsity method has higher accuracy and flexibility. The non-negative matrix factorisation with sparsity method has research value for the sky-subtraction on multi-object fibre spectroscopic telescope surveys. To demonstrate the effectiveness and superiority of the proposed algorithm, experiments are performed on Large Sky Area Multi-Object Fiber Spectroscopic Telescope data, as the mechanisms of the multi-object fibre spectroscopic telescopes are similar.

  8. Minimal representation of matrix valued white stochastic processes and U-D factorisation of algorithms for optimal control

    NASA Astrophysics Data System (ADS)

    Van Willigenburg, L. Gerard; De Koning, Willem L.

    2013-02-01

    Two different descriptions are used in the literature to formulate the optimal dynamic output feedback control problem for linear dynamical systems with white stochastic parameters and quadratic criteria, called the optimal compensation problem. One describes the matrix valued white stochastic processes involved, using a sum of deterministic matrices each one multiplied by a scalar stochastic process that is independent of the others. Another, that is more general and concise, uses Kronecker products instead. This article relates the statistics of both descriptions and shows their advantages and disadvantages. As to the first description, an important result that comes out is the minimum number of matrices multiplied by scalar, independent, stochastic processes needed to represent a certain matrix valued white stochastic process, together with an associated minimal representation. As to the second description, an important result concerns the generation of all Kronecker products that represent relevant statistics. Both results facilitate the specification of statistics of systems with white stochastic parameters. The second part of this article further exploits these results to perform an U-D factorisation of an algorithm to compute optimal dynamic output feedback controllers (optimal compensators) for linear discrete-time systems with white stochastic parameters and quadratic sum criteria. U-D factorisation of this type of algorithm is new. By solving several numerical examples, the U-D factored algorithm is compared with a conventional algorithm.

  9. Convergence of the standard RLS method and UDUT factorisation of covariance matrix for solving the algebraic Riccati equation of the DLQR via heuristic approximate dynamic programming

    NASA Astrophysics Data System (ADS)

    Moraes Rêgo, Patrícia Helena; Viana da Fonseca Neto, João; Ferreira, Ernesto M.

    2015-08-01

    The main focus of this article is to present a proposal to solve, via UDUT factorisation, the convergence and numerical stability problems that are related to the covariance matrix ill-conditioning of the recursive least squares (RLS) approach for online approximations of the algebraic Riccati equation (ARE) solution associated with the discrete linear quadratic regulator (DLQR) problem formulated in the actor-critic reinforcement learning and approximate dynamic programming context. The parameterisations of the Bellman equation, utility function and dynamic system as well as the algebra of Kronecker product assemble a framework for the solution of the DLQR problem. The condition number and the positivity parameter of the covariance matrix are associated with statistical metrics for evaluating the approximation performance of the ARE solution via RLS-based estimators. The performance of RLS approximators is also evaluated in terms of consistence and polarisation when associated with reinforcement learning methods. The used methodology contemplates realisations of online designs for DLQR controllers that is evaluated in a multivariable dynamic system model.

  10. Towards geometric D6-brane model building on non-factorisable toroidal ℤ 4-orbifolds

    NASA Astrophysics Data System (ADS)

    Berasaluce-González, Mikel; Honecker, Gabriele; Seifert, Alexander

    2016-08-01

    We present a geometric approach to D-brane model building on the non-factorisable torus backgrounds of T 6/ ℤ 4, which are A 3 × A 3 and A 3 × A 1 × B 2. Based on the counting of `short' supersymmetric three-cycles per complex structure vev, the number of physically inequivalent lattice orientations with respect to the anti-holomorphic involution ℛ of the Type IIA/Ωℛ orientifold can be reduced to three for the A 3 × A 3 lattice and four for the A 3 × A 1 × B 2 lattice. While four independent three-cycles on A 3 × A 3 cannot accommodate phenomenologically interesting global models with a chiral spectrum, the eight-dimensional space of three-cycles on A 3 × A 1 × B 2 is rich enough to provide for particle physics models, with several globally consistent two- and four-generation Pati-Salam models presented here.

  11. Non-negative matrix factorisation methods for the spectral decomposition of MRS data from human brain tumours

    PubMed Central

    2012-01-01

    Background In-vivo single voxel proton magnetic resonance spectroscopy (SV 1H-MRS), coupled with supervised pattern recognition (PR) methods, has been widely used in clinical studies of discrimination of brain tumour types and follow-up of patients bearing abnormal brain masses. SV 1H-MRS provides useful biochemical information about the metabolic state of tumours and can be performed at short (< 45 ms) or long (> 45 ms) echo time (TE), each with particular advantages. Short-TE spectra are more adequate for detecting lipids, while the long-TE provides a much flatter signal baseline in between peaks but also negative signals for metabolites such as lactate. Both, lipids and lactate, are respectively indicative of specific metabolic processes taking place. Ideally, the information provided by both TE should be of use for clinical purposes. In this study, we characterise the performance of a range of Non-negative Matrix Factorisation (NMF) methods in two respects: first, to derive sources correlated with the mean spectra of known tissue types (tumours and normal tissue); second, taking the best performing NMF method for source separation, we compare its accuracy for class assignment when using the mixing matrix directly as a basis for classification, as against using the method for dimensionality reduction (DR). For this, we used SV 1H-MRS data with positive and negative peaks, from a widely tested SV 1H-MRS human brain tumour database. Results The results reported in this paper reveal the advantage of using a recently described variant of NMF, namely Convex-NMF, as an unsupervised method of source extraction from SV1H-MRS. Most of the sources extracted in our experiments closely correspond to the mean spectra of some of the analysed tumour types. This similarity allows accurate diagnostic predictions to be made both in fully unsupervised mode and using Convex-NMF as a DR step previous to standard supervised classification. The obtained results are comparable to, or

  12. Controllability discrepancy and irreducibility/reducibility of Floquet factorisations in linear continuous-time periodic systems

    NASA Astrophysics Data System (ADS)

    Zhou, Jun; Lu, Xinbiao; Qian, Huimin

    2016-09-01

    The paper reports interesting but unnoticed facts about irreducibility (resp., reducibility) of Flouqet factorisations and their harmonic implication in term of controllability in finite-dimensional linear continuous-time periodic (FDLCP) systems. Reducibility and irreducibility are attributed to matrix logarithm algorithms during computing Floquet factorisations in FDLCP systems, which are a pair of essential features but remain unnoticed in the Floquet theory so far. The study reveals that reducible Floquet factorisations may bring in harmonic waves variance into the Fourier analysis of FDLCP systems that in turn may alter our interpretation of controllability when the Floquet factors are used separately during controllability testing; namely, controllability interpretation discrepancy (or simply, controllability discrepancy) may occur and must be examined whenever reducible Floquet factorisations are involved. On the contrary, when irreducible Floquet factorisations are employed, controllability interpretation discrepancy can be avoided. Examples are included to illustrate such observations.

  13. Concretising Factorisation of Quadratic Expressions

    ERIC Educational Resources Information Center

    Hoong, Leong Yew; Fwe, Yap Sook; Yvonne, Teo Mei Lin; Subramaniam, Thilagam d/o; Zaini, Irni Karen Bte Mohd; Chiew, Quek Eng; Karen, Tan Kang Ling

    2010-01-01

    The way quadratic factorisation was usually taught to students in Bukit View Secondary was through the familiar "cross-method." However, some teachers felt that a significant number of students could not use the method effectively even after careful demonstration through repeated examples. In addition, many secondary mathematics teachers…

  14. Using sparse LU factorisation to precondition GMRES for a family of similarly structured matrices arising from process modelling

    SciTech Connect

    Brooking, C.

    1996-12-31

    Process engineering software is used to simulate the operation of large chemical plants. Such simulations are used for a variety of tasks, including operator training. For the software to be of practical use for this, dynamic simulations need to run in real-time. The models that the simulation is based upon are written in terms of Differential Algebraic Equations (DAE`s). In the numerical time-integration of systems of DAE`s using an implicit method such as backward Euler, the solution of nonlinear systems is required at each integration point. When solved using Newton`s method, this leads to the repeated solution of nonsymmetric sparse linear systems. These systems range in size from 500 to 20,000 variables. A typical integration may require around 3000 timesteps, and if 4 Newton iterates were needed on each time step, then this means approximately 12,000 linear systems must be solved. The matrices produced by the simulations have a similar sparsity pattern throughout the integration. They are also severely ill-conditioned, and have widely-scattered spectra.

  15. U-D factorisation of the strengthened discrete-time optimal projection equations

    NASA Astrophysics Data System (ADS)

    Van Willigenburg, L. Gerard; De Koning, Willem L.

    2016-04-01

    Algorithms for optimal reduced-order dynamic output feedback control of linear discrete-time systems with white stochastic parameters are U-D factored in this paper. U-D factorisation enhances computational accuracy, stability and possibly efficiency. Since U-D factorisation of algorithms for optimal full-order output feedback controller design was recently published by us, this paper focusses on the U-D factorisation of the optimal oblique projection matrix that becomes part of the solution as a result of order-reduction. The equations producing the solution are known as the optimal projection equations which for discrete-time systems have been strengthened in the past. The U-D factored strengthened discrete-time optimal projection equations are presented in this paper by means of a transformation that has to be applied recursively until convergence. The U-D factored and conventional algorithms are compared through a series of examples.

  16. Faces of matrix models

    NASA Astrophysics Data System (ADS)

    Morozov, A.

    2012-08-01

    Partition functions of eigenvalue matrix models possess a number of very different descriptions: as matrix integrals, as solutions to linear and nonlinear equations, as τ-functions of integrable hierarchies and as special-geometry prepotentials, as result of the action of W-operators and of various recursions on elementary input data, as gluing of certain elementary building blocks. All this explains the central role of such matrix models in modern mathematical physics: they provide the basic "special functions" to express the answers and relations between them, and they serve as a dream model of what one should try to achieve in any other field.

  17. Multiscale entropy analysis of resting-state magnetoencephalogram with tensor factorisations in Alzheimer's disease.

    PubMed

    Escudero, Javier; Acar, Evrim; Fernández, Alberto; Bro, Rasmus

    2015-10-01

    Tensor factorisations have proven useful to model amplitude and spectral information of brain recordings. Here, we assess the usefulness of tensor factorisations in the multiway analysis of other brain signal features in the context of complexity measures recently proposed to inspect multiscale dynamics. We consider the "refined composite multiscale entropy" (rcMSE), which computes entropy "profiles" showing levels of physiological complexity over temporal scales for individual signals. We compute the rcMSE of resting-state magnetoencephalogram (MEG) recordings from 36 patients with Alzheimer's disease and 26 control subjects. Instead of traditional simple visual examinations, we organise the entropy profiles as a three-way tensor to inspect relationships across temporal and spatial scales and subjects with multiway data analysis techniques based on PARAFAC and PARAFAC2 factorisations. A PARAFAC2 model with two factors was appropriate to account for the interactions in the entropy tensor between temporal scales and MEG channels for all subjects. Moreover, the PARAFAC2 factors had information related to the subjects' diagnosis, achieving a cross-validated area under the ROC curve of 0.77. This confirms the suitability of tensor factorisations to represent electrophysiological brain data efficiently despite the unsupervised nature of these techniques. This article is part of a Special Issue entitled 'Neural data analysis'.

  18. A New Factorisation of a General Second Order Differential Equation

    ERIC Educational Resources Information Center

    Clegg, Janet

    2006-01-01

    A factorisation of a general second order ordinary differential equation is introduced from which the full solution to the equation can be obtained by performing two integrations. The method is compared with traditional methods for solving these type of equations. It is shown how the Green's function can be derived directly from the factorisation…

  19. Diffractive PDF fits and factorisation tests at HERA

    SciTech Connect

    Solano, Ada

    2011-07-15

    A DGLAP next-to-leading-order QCD analysis to extract the diffractive parton distribution functions, using DIS inclusive and dijet diffractive HERA data, is presented. Predictions based on the extracted parton densities are compared to diffractive dijet photoproduction data to discuss factorisation.

  20. Noncommutative spaces from matrix models

    NASA Astrophysics Data System (ADS)

    Lu, Lei

    Noncommutative (NC) spaces commonly arise as solutions to matrix model equations of motion. They are natural generalizations of the ordinary commutative spacetime. Such spaces may provide insights into physics close to the Planck scale, where quantum gravity becomes relevant. Although there has been much research in the literature, aspects of these NC spaces need further investigation. In this dissertation, we focus on properties of NC spaces in several different contexts. In particular, we study exact NC spaces which result from solutions to matrix model equations of motion. These spaces are associated with finite-dimensional Lie-algebras. More specifically, they are two-dimensional fuzzy spaces that arise from a three-dimensional Yang-Mills type matrix model, four-dimensional tensor-product fuzzy spaces from a tensorial matrix model, and Snyder algebra from a five-dimensional tensorial matrix model. In the first part of this dissertation, we study two-dimensional NC solutions to matrix equations of motion of extended IKKT-type matrix models in three-space-time dimensions. Perturbations around the NC solutions lead to NC field theories living on a two-dimensional space-time. The commutative limit of the solutions are smooth manifolds which can be associated with closed, open and static two-dimensional cosmologies. One particular solution is a Lorentzian fuzzy sphere, which leads to essentially a fuzzy sphere in the Minkowski space-time. In the commutative limit, this solution leads to an induced metric that does not have a fixed signature, and have a non-constant negative scalar curvature, along with singularities at two fixed latitudes. The singularities are absent in the matrix solution which provides a toy model for resolving the singularities of General relativity. We also discussed the two-dimensional fuzzy de Sitter space-time, which has irreducible representations of su(1,1) Lie-algebra in terms of principal, complementary and discrete series. Field

  1. Matrix model approach to cosmology

    NASA Astrophysics Data System (ADS)

    Chaney, A.; Lu, Lei; Stern, A.

    2016-03-01

    We perform a systematic search for rotationally invariant cosmological solutions to toy matrix models. These models correspond to the bosonic sector of Lorentzian Ishibashi, Kawai, Kitazawa and Tsuchiya (IKKT)-type matrix models in dimensions d less than ten, specifically d =3 and d =5 . After taking a continuum (or commutative) limit they yield d -1 dimensional Poisson manifolds. The manifolds have a Lorentzian induced metric which can be associated with closed, open, or static space-times. For d =3 , we obtain recursion relations from which it is possible to generate rotationally invariant matrix solutions which yield open universes in the continuum limit. Specific examples of matrix solutions have also been found which are associated with closed and static two-dimensional space-times in the continuum limit. The solutions provide for a resolution of cosmological singularities, at least within the context of the toy matrix models. The commutative limit reveals other desirable features, such as a solution describing a smooth transition from an initial inflation to a noninflationary era. Many of the d =3 solutions have analogues in higher dimensions. The case of d =5 , in particular, has the potential for yielding realistic four-dimensional cosmologies in the continuum limit. We find four-dimensional de Sitter d S4 or anti-de Sitter AdS4 solutions when a totally antisymmetric term is included in the matrix action. A nontrivial Poisson structure is attached to these manifolds which represents the lowest order effect of noncommutativity. For the case of AdS4 , we find one particular limit where the lowest order noncommutativity vanishes at the boundary, but not in the interior.

  2. q-Virasoro constraints in matrix models

    NASA Astrophysics Data System (ADS)

    Nedelin, Anton; Zabzine, Maxim

    2017-03-01

    The Virasoro constraints play the important role in the study of matrix models and in understanding of the relation between matrix models and CFTs. Recently the localization calculations in supersymmetric gauge theories produced new families of matrix models and we have very limited knowledge about these matrix models. We concentrate on elliptic generalization of hermitian matrix model which corresponds to calculation of partition function on S 3 × S 1 for vector multiplet. We derive the q-Virasoro constraints for this matrix model. We also observe some interesting algebraic properties of the q-Virasoro algebra.

  3. Parton distribution functions in Monte Carlo factorisation scheme

    NASA Astrophysics Data System (ADS)

    Jadach, S.; Płaczek, W.; Sapeta, S.; Siódmok, A.; Skrzypek, M.

    2016-12-01

    A next step in development of the KrkNLO method of including complete NLO QCD corrections to hard processes in a LO parton-shower Monte Carlo is presented. It consists of a generalisation of the method, previously used for the Drell-Yan process, to Higgs-boson production. This extension is accompanied with the complete description of parton distribution functions in a dedicated, Monte Carlo factorisation scheme, applicable to any process of production of one or more colour-neutral particles in hadron-hadron collisions.

  4. Thermoplastic matrix composite processing model

    NASA Technical Reports Server (NTRS)

    Dara, P. H.; Loos, A. C.

    1985-01-01

    The effects the processing parameters pressure, temperature, and time have on the quality of continuous graphite fiber reinforced thermoplastic matrix composites were quantitatively accessed by defining the extent to which intimate contact and bond formation has occurred at successive ply interfaces. Two models are presented predicting the extents to which the ply interfaces have achieved intimate contact and cohesive strength. The models are based on experimental observation of compression molded laminates and neat resin conditions, respectively. Identified as the mechanism explaining the phenomenon by which the plies bond to themselves is the theory of autohesion (or self diffusion). Theoretical predictions from the Reptation Theory between autohesive strength and contact time are used to explain the effects of the processing parameters on the observed experimental strengths. The application of a time-temperature relationship for autohesive strength predictions is evaluated. A viscoelastic compression molding model of a tow was developed to explain the phenomenon by which the prepreg ply interfaces develop intimate contact.

  5. Matrix model description of baryonic deformations

    SciTech Connect

    Bena, Iosif; Murayama, Hitoshi; Roiban, Radu; Tatar, Radu

    2003-03-13

    We investigate supersymmetric QCD with N{sub c} + 1 flavors using an extension of the recently proposed relation between gauge theories and matrix models.The impressive agreement between the two sides provides a beautiful confirmation of the extension of the gauge theory-matrix model relation to this case.

  6. Multiscale Modeling of Ceramic Matrix Composites

    NASA Technical Reports Server (NTRS)

    Bednarcyk, Brett A.; Mital, Subodh K.; Pineda, Evan J.; Arnold, Steven M.

    2015-01-01

    Results of multiscale modeling simulations of the nonlinear response of SiC/SiC ceramic matrix composites are reported, wherein the microstructure of the ceramic matrix is captured. This micro scale architecture, which contains free Si material as well as the SiC ceramic, is responsible for residual stresses that play an important role in the subsequent thermo-mechanical behavior of the SiC/SiC composite. Using the novel Multiscale Generalized Method of Cells recursive micromechanics theory, the microstructure of the matrix, as well as the microstructure of the composite (fiber and matrix) can be captured.

  7. Curvature and gravity actions for matrix models

    NASA Astrophysics Data System (ADS)

    Blaschke, Daniel N.; Steinacker, Harold

    2010-08-01

    We show how gravitational actions, in particular the Einstein-Hilbert action, can be obtained from additional terms in Yang-Mills matrix models. This is consistent with recent results on induced gravitational actions in these matrix models, realizing spacetime as four-dimensional brane solutions. It opens up the possibility for a controlled non-perturbative description of gravity through simple matrix models, with interesting perspectives for the problem of vacuum energy. The relation with UV/IR mixing and non-commutative gauge theory is discussed.

  8. Micromechanical Modeling of Woven Metal Matrix Composites

    NASA Technical Reports Server (NTRS)

    Bednarcyk, Brett A.; Pindera, Marek-Jerzy

    1997-01-01

    This report presents the results of an extensive micromechanical modeling effort for woven metal matrix composites. The model is employed to predict the mechanical response of 8-harness (8H) satin weave carbon/copper (C/Cu) composites. Experimental mechanical results for this novel high thermal conductivity material were recently reported by Bednarcyk et al. along with preliminary model results. The micromechanics model developed herein is based on an embedded approach. A micromechanics model for the local (micro-scale) behavior of the woven composite, the original method of cells (Aboudi), is embedded in a global (macro-scale) micromechanics model (the three-dimensional generalized method of cells (GMC-3D) (Aboudi). This approach allows representation of true repeating unit cells for woven metal matrix composites via GMC-3D, and representation of local effects, such as matrix plasticity, yarn porosity, and imperfect fiber-matrix bonding. In addition, the equations of GMC-3D were reformulated to significantly reduce the number of unknown quantities that characterize the deformation fields at the microlevel in order to make possible the analysis of actual microstructures of woven composites. The resulting micromechanical model (WCGMC) provides an intermediate level of geometric representation, versatility, and computational efficiency with respect to previous analytical and numerical models for woven composites, but surpasses all previous modeling work by allowing the mechanical response of a woven metal matrix composite, with an elastoplastic matrix, to be examined for the first time. WCGMC is employed to examine the effects of composite microstructure, porosity, residual stresses, and imperfect fiber-matrix bonding on the predicted mechanical response of 8H satin C/Cu. The previously reported experimental results are summarized, and the model predictions are compared to monotonic and cyclic tensile and shear test data. By considering appropriate levels of porosity

  9. Matrix models of 2d gravity

    SciTech Connect

    Ginsparg, P.

    1991-01-01

    These are introductory lectures for a general audience that give an overview of the subject of matrix models and their application to random surfaces, 2d gravity, and string theory. They are intentionally 1.5 years out of date.

  10. Matrix models of 2d gravity

    SciTech Connect

    Ginsparg, P.

    1991-12-31

    These are introductory lectures for a general audience that give an overview of the subject of matrix models and their application to random surfaces, 2d gravity, and string theory. They are intentionally 1.5 years out of date.

  11. A matrix model from string field theory

    NASA Astrophysics Data System (ADS)

    Zeze, Syoji

    2016-09-01

    We demonstrate that a Hermitian matrix model can be derived from level truncated open string field theory with Chan-Paton factors. The Hermitian matrix is coupled with a scalar and U(N) vectors which are responsible for the D-brane at the tachyon vacuum. Effective potential for the scalar is evaluated both for finite and large N. Increase of potential height is observed in both cases. The large N matrix integral is identified with a system of N ZZ branes and a ghost FZZT brane.

  12. Chaos in the BMN matrix model

    NASA Astrophysics Data System (ADS)

    Asano, Yuhma; Kawai, Daisuke; Yoshida, Kentaroh

    2015-06-01

    We study classical chaotic motions in the Berenstein-Maldacena-Nastase (BMN) matrix model. For this purpose, it is convenient to focus upon a reduced system composed of two-coupled anharmonic oscillators by supposing an ansatz. We examine three ansätze: 1) two pulsating fuzzy spheres, 2) a single Coulomb-type potential, and 3) integrable fuzzy spheres. For the first two cases, we show the existence of chaos by computing Poincaré sections and a Lyapunov spectrum. The third case leads to an integrable system. As a result, the BMN matrix model is not integrable in the sense of Liouville, though there may be some integrable subsectors.

  13. Expansion of Binomials and Factorisation of Quadratic Expressions: Exploring a Vedic Method

    ERIC Educational Resources Information Center

    Nataraj, Mala Saraswathy; Thomas, Michael O. J.

    2006-01-01

    Many students have traditionally found the processes of algebraic manipulation, especially factorisation, difficult to learn. This study investigated the value of introducing students to a Vedic method of multiplication of arithmetic numbers to algebra that is very visual in its application. This research considered a possible role of the…

  14. Schwarzschild geometry emerging from matrix models

    NASA Astrophysics Data System (ADS)

    Blaschke, Daniel N.; Steinacker, Harold

    2010-09-01

    We demonstrate how various geometries can emerge from Yang-Mills-type matrix models with branes, and consider the examples of Schwarzschild and Reissner-Nordström geometries. We provide an explicit embedding of these branes in \\mathds{R}^{2,5} and \\mathds{R}^{4,6}, as well as an appropriate Poisson resp. symplectic structure which determines the non-commutativity of spacetime. The embedding is asymptotically flat with the asymptotically constant θμν for large r, and therefore suitable for a generalization to many-body configurations. This is an illustration of our previous work (Blaschke and Steinacker 2010 Class. Quantum Grav. 27 165010 (arXiv:1003.4132)), where we have shown how the Einstein-Hilbert action can be realized within such matrix models.

  15. Efficient Matrix Models for Relational Learning

    DTIC Science & Technology

    2009-10-01

    Haesun Park. Orthogonal nonnegative matrix tri-factorizations for clustering. In Tina Eliassi-Rad, Lyle H. Ungar , Mark Craven, and Dimitrios Gunopulos...97] A. Popescul and L. Ungar . Structural logistic regression for link analysis. KDD Workshop on Multi-Relational Data Mining, 2003. [98] Yuan Qi and...asking questions, pages 167–192. Morgan Kaufman, 1986. [112] Andrew I. Schein, Lawrence K. Saul, and Lyle H. Ungar . A generalized linear model for

  16. Nano- and mesoscale modeling of cement matrix

    NASA Astrophysics Data System (ADS)

    Yu, Zechuan; Lau, Denvid

    2015-04-01

    Atomistic simulations of cementitious material can enrich our understanding of its structural and mechanical properties, whereas current computational capacities restrict the investigation length scale within 10 nm. In this context, coarse-grained simulations can translate the information from nanoscale to mesoscale, thus bridging the multi-scale investigations. Here, we develop a coarse-grained model of cement matrix using the concept of disk-like building block. The objective is to introduce a new method to construct a coarse-grained model of cement, which could contribute to the scale-bridging issue from nanoscale to mesoscale. PAC codes: 07.05.Tp, 62.25.-g, 82.70.Dd

  17. Nano- and mesoscale modeling of cement matrix.

    PubMed

    Yu, Zechuan; Lau, Denvid

    2015-01-01

    Atomistic simulations of cementitious material can enrich our understanding of its structural and mechanical properties, whereas current computational capacities restrict the investigation length scale within 10 nm. In this context, coarse-grained simulations can translate the information from nanoscale to mesoscale, thus bridging the multi-scale investigations. Here, we develop a coarse-grained model of cement matrix using the concept of disk-like building block. The objective is to introduce a new method to construct a coarse-grained model of cement, which could contribute to the scale-bridging issue from nanoscale to mesoscale. PAC codes: 07.05.Tp, 62.25.-g, 82.70.Dd.

  18. Spectral density of the correlation matrix of factor models: a random matrix theory approach.

    PubMed

    Lillo, F; Mantegna, R N

    2005-07-01

    We studied the eigenvalue spectral density of the correlation matrix of factor models of multivariate time series. By making use of the random matrix theory, we analytically quantified the effect of statistical uncertainty on the spectral density due to the finiteness of the sample. We considered a broad range of models, ranging from one-factor models to hierarchical multifactor models.

  19. Transition matrix model for evolutionary game dynamics

    NASA Astrophysics Data System (ADS)

    Ermentrout, G. Bard; Griffin, Christopher; Belmonte, Andrew

    2016-03-01

    We study an evolutionary game model based on a transition matrix approach, in which the total change in the proportion of a population playing a given strategy is summed directly over contributions from all other strategies. This general approach combines aspects of the traditional replicator model, such as preserving unpopulated strategies, with mutation-type dynamics, which allow for nonzero switching to unpopulated strategies, in terms of a single transition function. Under certain conditions, this model yields an endemic population playing non-Nash-equilibrium strategies. In addition, a Hopf bifurcation with a limit cycle may occur in the generalized rock-scissors-paper game, unlike the replicator equation. Nonetheless, many of the Folk Theorem results are shown to hold for this model.

  20. String coupling and interactions in type IIB matrix model

    SciTech Connect

    Kitazawa, Yoshihisa; Nagaoka, Satoshi

    2009-05-15

    We investigate the interactions of closed strings in a IIB matrix model. The basic interaction of the closed superstring is realized by the recombination of two intersecting strings. Such interaction is investigated in a IIB matrix model via two-dimensional noncommutative gauge theory in the IR limit. By estimating the probability of the recombination, we identify the string coupling g{sub s} in the IIB matrix model. We confirm that our identification is consistent with matrix string theory.

  1. Exclusive J/\\psi production at the LHC in the k T factorisation approach

    NASA Astrophysics Data System (ADS)

    Jones, S. P.; Martin, A. D.; Ryskin, M. G.; Teubner, T.

    2017-03-01

    The recent LHCb data for exclusive J/\\psi peripheral production at 13 TeV motivate an improved ‘NLO’ analysis to estimate the gluon distribution at low x in which we re-calculate the rapidity gap survival factors and use a more precise expression for the photon flux. We comment on the difference between the k T and collinear factorisation approaches.

  2. Superstring vertex operators in type IIB matrix model

    SciTech Connect

    Kitazawa, Yoshihisa; Nagaoka, Satoshi

    2008-06-15

    We clarify the relation between the vertex operators in type IIB matrix model and superstring. Green-Schwarz light-cone closed superstring theory is obtained from IIB matrix model on two-dimensional noncommutative backgrounds. Superstring vertex operators should be reproduced from those of IIB matrix model through this connection. Indeed, we confirm that supergravity vertex operators in IIB matrix model on the two-dimensional backgrounds reduce to those in superstring theory. Noncommutativity plays an important role in our identification. Through this correspondence, we can reproduce superstring scattering amplitudes from IIB matrix model.

  3. Random matrix model of adiabatic quantum computing

    SciTech Connect

    Mitchell, David R.; Adami, Christoph; Lue, Waynn; Williams, Colin P.

    2005-05-15

    We present an analysis of the quantum adiabatic algorithm for solving hard instances of 3-SAT (an NP-complete problem) in terms of random matrix theory (RMT). We determine the global regularity of the spectral fluctuations of the instantaneous Hamiltonians encountered during the interpolation between the starting Hamiltonians and the ones whose ground states encode the solutions to the computational problems of interest. At each interpolation point, we quantify the degree of regularity of the average spectral distribution via its Brody parameter, a measure that distinguishes regular (i.e., Poissonian) from chaotic (i.e., Wigner-type) distributions of normalized nearest-neighbor spacings. We find that for hard problem instances - i.e., those having a critical ratio of clauses to variables - the spectral fluctuations typically become irregular across a contiguous region of the interpolation parameter, while the spectrum is regular for easy instances. Within the hard region, RMT may be applied to obtain a mathematical model of the probability of avoided level crossings and concomitant failure rate of the adiabatic algorithm due to nonadiabatic Landau-Zener-type transitions. Our model predicts that if the interpolation is performed at a uniform rate, the average failure rate of the quantum adiabatic algorithm, when averaged over hard problem instances, scales exponentially with increasing problem size.

  4. Modeling the formation of cell-matrix adhesions on a single 3D matrix fiber.

    PubMed

    Escribano, J; Sánchez, M T; García-Aznar, J M

    2015-11-07

    Cell-matrix adhesions are crucial in different biological processes like tissue morphogenesis, cell motility, and extracellular matrix remodeling. These interactions that link cell cytoskeleton and matrix fibers are built through protein clutches, generally known as adhesion complexes. The adhesion formation process has been deeply studied in two-dimensional (2D) cases; however, the knowledge is limited for three-dimensional (3D) cases. In this work, we simulate different local extracellular matrix properties in order to unravel the fundamental mechanisms that regulate the formation of cell-matrix adhesions in 3D. We aim to study the mechanical interaction of these biological structures through a three dimensional discrete approach, reproducing the transmission pattern force between the cytoskeleton and a single extracellular matrix fiber. This numerical model provides a discrete analysis of the proteins involved including spatial distribution, interaction between them, and study of the different phenomena, such as protein clutches unbinding or protein unfolding.

  5. High Strain Rate Deformation Modeling of a Polymer Matrix Composite. Part 1; Matrix Constitutive Equations

    NASA Technical Reports Server (NTRS)

    Goldberg, Robert K.; Stouffer, Donald C.

    1998-01-01

    Recently applications have exposed polymer matrix composite materials to very high strain rate loading conditions, requiring an ability to understand and predict the material behavior under these extreme conditions. In this first paper of a two part report, background information is presented, along with the constitutive equations which will be used to model the rate dependent nonlinear deformation response of the polymer matrix. Strain rate dependent inelastic constitutive models which were originally developed to model the viscoplastic deformation of metals have been adapted to model the nonlinear viscoelastic deformation of polymers. The modified equations were correlated by analyzing the tensile/ compressive response of both 977-2 toughened epoxy matrix and PEEK thermoplastic matrix over a variety of strain rates. For the cases examined, the modified constitutive equations appear to do an adequate job of modeling the polymer deformation response. A second follow-up paper will describe the implementation of the polymer deformation model into a composite micromechanical model, to allow for the modeling of the nonlinear, rate dependent deformation response of polymer matrix composites.

  6. Modeling for Matrix Multicracking Evolution of Cross-ply Ceramic-Matrix Composites Using Energy Balance Approach

    NASA Astrophysics Data System (ADS)

    Longbiao, Li

    2015-12-01

    The matrix multicracking evolution of cross-ply ceramic-matrix composites (CMCs) has been investigated using energy balance approach. The multicracking of cross-ply CMCs was classified into five modes, i.e., (1) mode 1: transverse multicracking; (2) mode 2: transverse multicracking and matrix multicracking with perfect fiber/matrix interface bonding; (3) mode 3: transverse multicracking and matrix multicracking with fiber/matrix interface debonding; (4) mode 4: matrix multicracking with perfect fiber/matrix interface bonding; and (5) mode 5: matrix multicracking with fiber/matrix interface debonding. The stress distributions of four cracking modes, i.e., mode 1, mode 2, mode 3 and mode 5, are analysed using shear-lag model. The matrix multicracking evolution of mode 1, mode 2, mode 3 and mode 5, has been determined using energy balance approach. The effects of ply thickness and fiber volume fraction on matrix multicracking evolution of cross-ply CMCs have been investigated.

  7. Probabilistic Modeling of Ceramic Matrix Composite Strength

    NASA Technical Reports Server (NTRS)

    Shan, Ashwin R.; Murthy, Pappu L. N.; Mital, Subodh K.; Bhatt, Ramakrishna T.

    1998-01-01

    Uncertainties associated with the primitive random variables such as manufacturing process (processing temperature, fiber volume ratio, void volume ratio), constituent properties (fiber, matrix and interface), and geometric parameters (ply thickness, interphase thickness) have been simulated to quantify the scatter in the first matrix cracking strength (FMCS) and the ultimate tensile strength of SCS-6/RBSN (SiC fiber (SCS-6) reinforced reaction-bonded silicon nitride composite) ceramic matrix composite laminate at room temperature. Cumulative probability distribution function for the FMCS and ultimate tensile strength at room temperature (RT) of (0)(sub 8), (0(sub 2)/90(sub 2), and (+/-45(sub 2))(sub S) laminates have been simulated and the sensitivity of primitive variables to the respective strengths have been quantified. Computationally predicted scatter of the strengths for a uniaxial laminate have been compared with those from limited experimental data. Also the experimental procedure used in the tests has been described briefly. Results show a very good agreement between the computational simulation and the experimental data. Dominating failure modes in (0)(sub 8), (0/90)(sub s) and (+/-45)(sub S) laminates have been identified. Results indicate that the first matrix cracking strength for the (0)(sub S), and (0/90)(sub S) laminates is sensitive to the thermal properties, modulus and strengths of both the fiber and matrix whereas the ultimate tensile strength is sensitive to the fiber strength and the fiber volume ratio. In the case of a (+/-45)(sub S), laminate, both the FMCS and the ultimate tensile strengths have a small scatter range and are sensitive to the fiber tensile strength as well as the fiber volume ratio.

  8. Matrix model for non-Abelian quantum Hall states

    NASA Astrophysics Data System (ADS)

    Dorey, Nick; Tong, David; Turner, Carl

    2016-08-01

    We propose a matrix quantum mechanics for a class of non-Abelian quantum Hall states. The model describes electrons which carry an internal SU(p ) spin. The ground states of the matrix model include spin-singlet generalizations of the Moore-Read and Read-Rezayi states and, in general, lie in a class previously introduced by Blok and Wen. The effective action for these states is a U(p ) Chern-Simons theory. We show how the matrix model can be derived from quantization of the vortices in this Chern-Simons theory and how the matrix model ground states can be reconstructed as correlation functions in the boundary WZW model.

  9. Positive Matrix Factorization Model for environmental data analyses

    EPA Pesticide Factsheets

    Positive Matrix Factorization is a receptor model developed by EPA to provide scientific support for current ambient air quality standards and implement those standards by identifying and quantifying the relative contributions of air pollution sources.

  10. Thermodynamics of the BMN matrix model at strong coupling

    NASA Astrophysics Data System (ADS)

    Costa, Miguel S.; Greenspan, Lauren; Penedones, João; Santos, Jorge E.

    2015-03-01

    We construct the black hole geometry dual to the deconfined phase of the BMN matrix model at strong 't Hooft coupling. We approach this solution from the limit of large temperature where it is approximately that of the non-extremal D0-brane geometry with a spherical S 8 horizon. This geometry preserves the SO(9) symmetry of the matrix model trivial vacuum. As the temperature decreases the horizon becomes deformed and breaks the SO(9) to the SO(6) × SO(3) symmetry of the matrix model. When the black hole free energy crosses zero the system undergoes a phase transition to the confined phase described by a Lin-Maldacena geometry. We determine this critical temperature, whose computation is also within reach of Monte Carlo simulations of the matrix model.

  11. Entanglement entropy of Wilson loops: Holography and matrix models

    NASA Astrophysics Data System (ADS)

    Gentle, Simon A.; Gutperle, Michael

    2014-09-01

    A half-Bogomol'nyi-Prasad-Sommerfeld circular Wilson loop in N=4 SU(N) supersymmetric Yang-Mills theory in an arbitrary representation is described by a Gaussian matrix model with a particular insertion. The additional entanglement entropy of a spherical region in the presence of such a loop was recently computed by Lewkowycz and Maldacena using exact matrix model results. In this paper we utilize the supergravity solutions that are dual to such Wilson loops in a representation with order N2 boxes to calculate this entropy holographically. Employing the matrix model results of Gomis, Matsuura, Okuda and Trancanelli we express this holographic entanglement entropy in a form that can be compared with the calculation of Lewkowycz and Maldacena. We find complete agreement between the matrix model and holographic calculations.

  12. Modelling the random effects covariance matrix in longitudinal data.

    PubMed

    Daniels, Michael J; Zhao, Yan D

    2003-05-30

    A common class of models for longitudinal data are random effects (mixed) models. In these models, the random effects covariance matrix is typically assumed constant across subject. However, in many situations this matrix may differ by measured covariates. In this paper, we propose an approach to model the random effects covariance matrix by using a special Cholesky decomposition of the matrix. In particular, we will allow the parameters that result from this decomposition to depend on subject-specific covariates and also explore ways to parsimoniously model these parameters. An advantage of this parameterization is that there is no concern about the positive definiteness of the resulting estimator of the covariance matrix. In addition, the parameters resulting from this decomposition have a sensible interpretation. We propose fully Bayesian modelling for which a simple Gibbs sampler can be implemented to sample from the posterior distribution of the parameters. We illustrate these models on data from depression studies and examine the impact of heterogeneity in the covariance matrix on estimation of both fixed and random effects.

  13. Higgs production via gluon fusion in k{sub T} factorisation

    SciTech Connect

    Hautmann, F.; Jung, H.; Pandis, V.

    2011-07-15

    Theoretical studies of Higgs production via gluon fusion are frequently carried out in the limit where the top quark mass is much larger than the Higgs mass, an approximation which reduces the top quark loop to an effective vertex. We present a numerical analysis of the error thus introduced by performing a Monte Carlo calculation for gg{yields}h in k{sub T}-factorisation, using the parton shower generator CASCADE. By examining both inclusive and exclusive quantities, we find that retaining the top-mass dependence results in only a small enhancement of the cross-section. We then proceed to compare CASCADE to the collinear Monte Carlos PYTHIA, MC-NLO and POWHEG.

  14. MOEMS Modeling Using the Geometrical Matrix Toolbox

    NASA Technical Reports Server (NTRS)

    Wilson, William C.; Atkinson, Gary M.

    2005-01-01

    New technologies such as MicroOptoElectro-Mechanical Systems (MOEMS) require new modeling tools. These tools must simultaneously model the optical, electrical, and mechanical domains and the interactions between these domains. To facilitate rapid prototyping of these new technologies an optical toolbox has been developed for modeling MOEMS devices. The toolbox models are constructed using MATLAB's dynamical simulator, Simulink. Modeling toolboxes will allow users to focus their efforts on system design and analysis as opposed to developing component models. This toolbox was developed to facilitate rapid modeling and design of a MOEMS based laser ultrasonic receiver system.

  15. Strain Rate Dependent Modeling of Polymer Matrix Composites

    NASA Technical Reports Server (NTRS)

    Goldberg, Robert K.; Stouffer, Donald C.

    1999-01-01

    A research program is in progress to develop strain rate dependent deformation and failure models for the analysis of polymer matrix composites subject to high strain rate impact loads. Strain rate dependent inelastic constitutive equations have been developed to model the polymer matrix, and have been incorporated into a micromechanics approach to analyze polymer matrix composites. The Hashin failure criterion has been implemented within the micromechanics results to predict ply failure strengths. The deformation model has been implemented within LS-DYNA, a commercially available transient dynamic finite element code. The deformation response and ply failure stresses for the representative polymer matrix composite AS4/PEEK have been predicted for a variety of fiber orientations and strain rates. The predicted results compare favorably to experimentally obtained values.

  16. Modeling the Stress Strain Behavior of Woven Ceramic Matrix Composites

    NASA Technical Reports Server (NTRS)

    Morscher, Gregory N.

    2006-01-01

    Woven SiC fiber reinforced SiC matrix composites represent one of the most mature composite systems to date. Future components fabricated out of these woven ceramic matrix composites are expected to vary in shape, curvature, architecture, and thickness. The design of future components using woven ceramic matrix composites necessitates a modeling approach that can account for these variations which are physically controlled by local constituent contents and architecture. Research over the years supported primarily by NASA Glenn Research Center has led to the development of simple mechanistic-based models that can describe the entire stress-strain curve for composite systems fabricated with chemical vapor infiltrated matrices and melt-infiltrated matrices for a wide range of constituent content and architecture. Several examples will be presented that demonstrate the approach to modeling which incorporates a thorough understanding of the stress-dependent matrix cracking properties of the composite system.

  17. Dynamical phase space from an SO (d ,d ) matrix model

    NASA Astrophysics Data System (ADS)

    Chatzistavrakidis, Athanasios

    2014-12-01

    It is shown that a matrix model with SO (d ,d ) global symmetry is derived from a generalized Yang-Mills theory on the standard Courant algebroid. This model keeps all the positive features of the well-studied type IIB matrix model, and it has many additional welcome properties. We show that it not only captures the dynamics of spacetime, but it should be associated with the dynamics of phase space. This is supported by a large set of classical solutions of its equations of motion, which corresponds to phase spaces of noncommutative curved manifolds and points to a new mechanism of emergent gravity. The model possesses a symmetry that exchanges positions and momenta, in analogy to quantum mechanics. It is argued that the emergence of phase space in the model is an essential feature for the investigation of the precise relation of matrix models to string theory and quantum gravity.

  18. Geometric deviation modeling by kinematic matrix based on Lagrangian coordinate

    NASA Astrophysics Data System (ADS)

    Liu, Weidong; Hu, Yueming; Liu, Yu; Dai, Wanyi

    2015-09-01

    Typical representation of dimension and geometric accuracy is limited to the self-representation of dimension and geometric deviation based on geometry variation thinking, yet the interactivity affection of geometric variation and gesture variation of multi-rigid body is not included. In this paper, a kinematic matrix model based on Lagrangian coordinate is introduced, with the purpose of unified model for geometric variation and gesture variation and their interactive and integrated analysis. Kinematic model with joint, local base and movable base is built. The ideal feature of functional geometry is treated as the base body; the fitting feature of functional geometry is treated as the adjacent movable body; the local base of the kinematic model is fixed onto the ideal geometry, and the movable base of the kinematic model is fixed onto the fitting geometry. Furthermore, the geometric deviation is treated as relative location or rotation variation between the movable base and the local base, and it's expressed by the Lagrangian coordinate. Moreover, kinematic matrix based on Lagrangian coordinate for different types of geometry tolerance zones is constructed, and total freedom for each kinematic model is discussed. Finally, the Lagrangian coordinate library, kinematic matrix library for geometric deviation modeling is illustrated, and an example of block and piston fits is introduced. Dimension and geometric tolerances of the shaft and hole fitting feature are constructed by kinematic matrix and Lagrangian coordinate, and the results indicate that the proposed kinematic matrix is capable and robust in dimension and geometric tolerances modeling.

  19. Amerciamysis bahia Stochastic Matrix Population Model for Laboratory Populations

    EPA Science Inventory

    The population model described here is a stochastic, density-independent matrix model for integrating the effects of toxicants on survival and reproduction of the marine invertebrate, Americamysis bahia. The model was constructed using Microsoft® Excel 2003. The focus of the mode...

  20. Proposed framework for thermomechanical life modeling of metal matrix composites

    NASA Technical Reports Server (NTRS)

    Halford, Gary R.; Lerch, Bradley A.; Saltsman, James F.

    1993-01-01

    The framework of a mechanics of materials model is proposed for thermomechanical fatigue (TMF) life prediction of unidirectional, continuous-fiber metal matrix composites (MMC's). Axially loaded MMC test samples are analyzed as structural components whose fatigue lives are governed by local stress-strain conditions resulting from combined interactions of the matrix, interfacial layer, and fiber constituents. The metallic matrix is identified as the vehicle for tracking fatigue crack initiation and propagation. The proposed framework has three major elements. First, TMF flow and failure characteristics of in situ matrix material are approximated from tests of unreinforced matrix material, and matrix TMF life prediction equations are numerically calibrated. The macrocrack initiation fatigue life of the matrix material is divided into microcrack initiation and microcrack propagation phases. Second, the influencing factors created by the presence of fibers and interfaces are analyzed, characterized, and documented in equation form. Some of the influences act on the microcrack initiation portion of the matrix fatigue life, others on the microcrack propagation life, while some affect both. Influencing factors include coefficient of thermal expansion mismatch strains, residual (mean) stresses, multiaxial stress states, off-axis fibers, internal stress concentrations, multiple initiation sites, nonuniform fiber spacing, fiber debonding, interfacial layers and cracking, fractured fibers, fiber deflections of crack fronts, fiber bridging of matrix cracks, and internal oxidation along internal interfaces. Equations exist for some, but not all, of the currently identified influencing factors. The third element is the inclusion of overriding influences such as maximum tensile strain limits of brittle fibers that could cause local fractures and ensuing catastrophic failure of surrounding matrix material. Some experimental data exist for assessing the plausibility of the proposed

  1. Holography and entropy bounds in the plane wave matrix model

    SciTech Connect

    Bousso, Raphael; Mints, Aleksey L.

    2006-06-15

    As a quantum theory of gravity, matrix theory should provide a realization of the holographic principle, in the sense that a holographic theory should contain one binary degree of freedom per Planck area. We present evidence that Bekenstein's entropy bound, which is related to area differences, is manifest in the plane wave matrix model. If holography is implemented in this way, we predict crossover behavior at strong coupling when the energy exceeds N{sup 2} in units of the mass scale.

  2. Matrix model maps in AdS/CFT correspondence

    SciTech Connect

    Donos, Aristomenis; Jevicki, Antal; Rodrigues, Joao P.

    2005-12-15

    We discuss an extension of a map between BPS states and free fermions. The extension involves states associated with a full two matrix problem which are constructed using a sequence of integral equations. A two parameter set of matrix model eigenstates is then related to states in SUGRA. Their wave functions are characterized by nontrivial dependence on the radial coordinate of AdS and of the Sphere, respectively. A kernel defining a one to one map between these states is then constructed.

  3. Bayesian hierarchical model for large-scale covariance matrix estimation.

    PubMed

    Zhu, Dongxiao; Hero, Alfred O

    2007-12-01

    Many bioinformatics problems implicitly depend on estimating large-scale covariance matrix. The traditional approaches tend to give rise to high variance and low accuracy due to "overfitting." We cast the large-scale covariance matrix estimation problem into the Bayesian hierarchical model framework, and introduce dependency between covariance parameters. We demonstrate the advantages of our approaches over the traditional approaches using simulations and OMICS data analysis.

  4. $\\cN$-FOLD SUPERSYMMETRY IN QUANTUM MECHANICAL MATRIX MODELS

    NASA Astrophysics Data System (ADS)

    Tanaka, Toshiaki

    2012-03-01

    We formulate Ņ-fold supersymmetry in quantum mechanical matrix models. As an example, we construct general two-by-two Hermitian matrix two-fold supersymmetric quantum mechanical systems. We find that there are two inequivalent such systems, both of which are characterized by two arbitrary scalar functions, and one of which does not reduce to the scalar system. The obtained systems are all weakly quasi-solvable.

  5. Hierarchical spatiotemporal matrix models for characterizing invasions

    USGS Publications Warehouse

    Hooten, M.B.; Wikle, C.K.; Dorazio, R.M.; Royle, J. Andrew

    2007-01-01

    The growth and dispersal of biotic organisms is an important subject in ecology. Ecologists are able to accurately describe survival and fecundity in plant and animal populations and have developed quantitative approaches to study the dynamics of dispersal and population size. Of particular interest are the dynamics of invasive species. Such nonindigenous animals and plants can levy significant impacts on native biotic communities. Effective models for relative abundance have been developed; however, a better understanding of the dynamics of actual population size (as opposed to relative abundance) in an invasion would be beneficial to all branches of ecology. In this article, we adopt a hierarchical Bayesian framework for modeling the invasion of such species while addressing the discrete nature of the data and uncertainty associated with the probability of detection. The nonlinear dynamics between discrete time points are intuitively modeled through an embedded deterministic population model with density-dependent growth and dispersal components. Additionally, we illustrate the importance of accommodating spatially varying dispersal rates. The method is applied to the specific case of the Eurasian Collared-Dove, an invasive species at mid-invasion in the United States at the time of this writing. ?? 2006, The International Biometric Society.

  6. Hierarchical spatiotemporal matrix models for characterizing invasions

    USGS Publications Warehouse

    Hooten, Mevin B.; Wikle, Christopher K.; Dorazio, Robert M.; Royle, J. Andrew

    2007-01-01

    The growth and dispersal of biotic organisms is an important subject in ecology. Ecologists are able to accurately describe survival and fecundity in plant and animal populations and have developed quantitative approaches to study the dynamics of dispersal and population size. Of particular interest are the dynamics of invasive species. Such nonindigenous animals and plants can levy significant impacts on native biotic communities. Effective models for relative abundance have been developed; however, a better understanding of the dynamics of actual population size (as opposed to relative abundance) in an invasion would be beneficial to all branches of ecology. In this article, we adopt a hierarchical Bayesian framework for modeling the invasion of such species while addressing the discrete nature of the data and uncertainty associated with the probability of detection. The nonlinear dynamics between discrete time points are intuitively modeled through an embedded deterministic population model with density-dependent growth and dispersal components. Additionally, we illustrate the importance of accommodating spatially varying dispersal rates. The method is applied to the specific case of the Eurasian Collared-Dove, an invasive species at mid-invasion in the United States at the time of this writing.

  7. Modeling Extracellular Matrix Reorganization in 3D Environments

    PubMed Central

    Harjanto, Dewi; Zaman, Muhammad H.

    2013-01-01

    Extracellular matrix (ECM) remodeling is a key physiological process that occurs in a number of contexts, including cell migration, and is especially important for cellular form and function in three-dimensional (3D) matrices. However, there have been few attempts to computationally model how cells modify their environment in a manner that accounts for both cellular properties and the architecture of the surrounding ECM. To this end, we have developed and validated a novel model to simulate matrix remodeling that explicitly defines cells in a 3D collagenous matrix. In our simulation, cells can degrade, deposit, or pull on local fibers, depending on the fiber density around each cell. The cells can also move within the 3D matrix. Different cell phenotypes can be modeled by varying key cellular parameters. Using the model we have studied how two model cancer cell lines, of differing invasiveness, modify matrices with varying fiber density in their vicinity by tracking the metric of fraction of matrix occupied by fibers. Our results quantitatively demonstrate that in low density environments, cells deposit more collagen to uniformly increase fibril fraction. On the other hand, in higher density environments, the less invasive model cell line reduced the fibril fraction as compared to the highly invasive phenotype. These results show good qualitative and quantitative agreement with existing experimental literature. Our simulation is therefore able to function as a novel platform to provide new insights into the clinically relevant and physiologically critical process of matrix remodeling by helping identify critical parameters that dictate cellular behavior in complex native-like environments. PMID:23341900

  8. Score Matrix for HWBI Forecast Model

    EPA Pesticide Factsheets

    2000-2010 Annual State-Scale Service and Domain scores used to support the approach for forecasting EPA's Human Well-Being Index. A modeling approach was developed based relationship function equations derived from select economic, social and ecosystem final goods and service scores and calculated human well-being index and related domain scores. These data are being used in a secondary capacity. The foundational data and scoring techniques were originally described in: a) U.S. EPA. 2012. Indicators and Methods for Constructing a U.S. Human Well-being Index (HWBI) for Ecosystem Services Research. Report. EPA/600/R-12/023. pp. 121; and b) U.S. EPA. 2014. Indicators and Methods for Evaluating Economic, Ecosystem and Social Services Provisioning. Report. EPA/600/R-14/184. pp. 174. Mode Smith, L. M., Harwell, L. C., Summers, J. K., Smith, H. M., Wade, C. M., Straub, K. R. and J.L. Case (2014).This dataset is associated with the following publication:Summers , K., L. Harwell , and L. Smith. A Model For Change: An Approach for Forecasting Well-Being From Service-Based Decisions. ECOLOGICAL INDICATORS. Elsevier Science Ltd, New York, NY, USA, 69: 295-309, (2016).

  9. Green-Schwarz superstring from type IIB matrix model

    SciTech Connect

    Kitazawa, Yoshihisa; Nagaoka, Satoshi

    2008-01-15

    We construct a Green-Schwarz (GS) light-cone closed superstring theory from the type IIB matrix model. A GS light-cone string action is derived from the two-dimensional N=8 U(n) noncommutative Yang-Mills (NCYM) theory by identifying a noncommutative scale with a string scale. The supersymmetry transformation for the light-cone gauge action is also derived from supersymmetry transformation for the IIB matrix model. By identifying the physical states and interaction vertices, string theory is perturbatively reproduced.

  10. Explicit examples of DIM constraints for network matrix models

    NASA Astrophysics Data System (ADS)

    Awata, Hidetoshi; Kanno, Hiroaki; Matsumoto, Takuya; Mironov, Andrei; Morozov, Alexei; Morozov, Andrey; Ohkubo, Yusuke; Zenkevich, Yegor

    2016-07-01

    Dotsenko-Fateev and Chern-Simons matrix models, which describe Nekrasov functions for SYM theories in different dimensions, are all incorporated into network matrix models with the hidden Ding-Iohara-Miki (DIM) symmetry. This lifting is especially simple for what we call balanced networks. Then, the Ward identities (known under the names of Virasoro/ {W} -constraints or loop equations or regularity condition for qq-characters) are also promoted to the DIM level, where they all become corollaries of a single identity.

  11. Modeling fatigue crack growth in cross ply titanium matrix composites

    NASA Technical Reports Server (NTRS)

    Bakuckas, J. G., Jr.; Johnson, W. S.

    1993-01-01

    In this study, the fatigue crack growth behavior of fiber bridging matrix cracks in cross-ply SCS-6/Ti-15-3 and SCS-6/Timetal-21S laminates containing center holes was investigated. Experimental observations revealed that matrix cracking was far more extensive and wide spread in the SCS-6/Ti-15-3 laminates compared to that in the SCS-6/Timetal-21S laminates. In addition, the fatigue life of the SCS-6/Ti-15-3 laminates was significantly longer than that of the SCS-6/Timetal-21S laminates. The matrix cracking observed in both material systems was analyzed using a fiber bridging (FB) model which was formulated using the boundary correction factors and weight functions for center hole specimen configurations. A frictional shear stress is assumed in the FB model and was used as a curve fitting parameter to model matrix crack growth data. The higher frictional shear stresses calculated in the SCS-6/Timetal-21S laminates resulted in lower stress intensity factors in the matrix and higher axial stresses in the fibers compared to those in the SCS-6/Ti-15-3 laminates at the same applied stress levels.

  12. Matrix models for quantifying competitive intransitivity.

    PubMed

    Ulrich, Werner; Soliveres, Santiago; Kryszewski, Wojciech; Maestre, Fernando T; Gotelli, Nicholas J

    2014-09-01

    Assessing the relative importance of intransitive competition networks in nature has been difficult because it requires a large number of pairwise competition experiments linked to observed field abundances of interacting species. Here we introduce metrics and statistical tests for evaluating the contribution of intransitivity to community structure using two kinds of data: competition matrices derived from the outcomes of pairwise experimental studies (C matrices) and species abundance matrices. We use C matrices to develop patch transition matrices (P) that predict community structure in a simple Markov chain model. We propose a randomization test to evaluate the degree of intransitivity from these P matrices in combination with empirical or simulated C matrices. Benchmark tests revealed that the methods could correctly detect intransitive competition networks, even in the absence of direct measures of pairwise competitive strength. These tests represent the first tools for estimating the degree of intransitivity in competitive networks from observational datasets. They can be applied to both spatio-temporal data sampled in homogeneous environments or across environmental gradients, and to experimental measures of pairwise interactions. To illustrate the methods, we analyzed empirical data matrices on the colonization of slug carrion by necrophagous flies and their parasitoids.

  13. HIGH DIMENSIONAL COVARIANCE MATRIX ESTIMATION IN APPROXIMATE FACTOR MODELS

    PubMed Central

    Fan, Jianqing; Liao, Yuan; Mincheva, Martina

    2012-01-01

    The variance covariance matrix plays a central role in the inferential theories of high dimensional factor models in finance and economics. Popular regularization methods of directly exploiting sparsity are not directly applicable to many financial problems. Classical methods of estimating the covariance matrices are based on the strict factor models, assuming independent idiosyncratic components. This assumption, however, is restrictive in practical applications. By assuming sparse error covariance matrix, we allow the presence of the cross-sectional correlation even after taking out common factors, and it enables us to combine the merits of both methods. We estimate the sparse covariance using the adaptive thresholding technique as in Cai and Liu (2011), taking into account the fact that direct observations of the idiosyncratic components are unavailable. The impact of high dimensionality on the covariance matrix estimation based on the factor structure is then studied. PMID:22661790

  14. HIGH DIMENSIONAL COVARIANCE MATRIX ESTIMATION IN APPROXIMATE FACTOR MODELS.

    PubMed

    Fan, Jianqing; Liao, Yuan; Mincheva, Martina

    2011-01-01

    The variance covariance matrix plays a central role in the inferential theories of high dimensional factor models in finance and economics. Popular regularization methods of directly exploiting sparsity are not directly applicable to many financial problems. Classical methods of estimating the covariance matrices are based on the strict factor models, assuming independent idiosyncratic components. This assumption, however, is restrictive in practical applications. By assuming sparse error covariance matrix, we allow the presence of the cross-sectional correlation even after taking out common factors, and it enables us to combine the merits of both methods. We estimate the sparse covariance using the adaptive thresholding technique as in Cai and Liu (2011), taking into account the fact that direct observations of the idiosyncratic components are unavailable. The impact of high dimensionality on the covariance matrix estimation based on the factor structure is then studied.

  15. Modeling of visible light channel based on matrix reconstruction

    NASA Astrophysics Data System (ADS)

    Liu, Wei; Zhou, Xian; Huo, Jiahao; Yan, Kaili

    2016-10-01

    Visible light channel modeling is one of the key technologies in visible light communication researches. But traditional Modified Monte Carlo Algorithm and Photon Tracing Algorithm still exist the problem of nesting too many times for visible light channel modeling, which leads to large computational complexity, so the system will take up too much computing resources. To solve this problem, we present the visible light channel modeling based on matrix reconstruction, which can simulate multiple diffuse reflection channel response in the case of low complexity. The simulation results show that the matrix reconstruction method can significantly reduce computational complexity comparing with the traditional modeling methods when the number of diffuse reflection increases. Meanwhile, the high modeling accuracy is guaranteed when the simulation time is shortened.

  16. Demographic matrix model for swallow-wort (Vincetoxicum spp.)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Demographic matrix modeling of plant populations can be a powerful tool to identify key life stage transitions that contribute the most to population growth of an invasive plant and hence should be targeted for disruption (weak links) by biological control and/or other control tactics. Therefore, t...

  17. Resilient organizations: matrix model and service line management.

    PubMed

    Westphal, Judith A

    2005-09-01

    Resilient organizations modify structures to meet the demands of the marketplace. The author describes a structure that enables multihospital organizations to innovate and rapidly adapt to changes. Service line management within a matrix model is an evolving organizational structure for complex systems in which nurses are pivotal members.

  18. Multivariate Linear Models of the Multitrait-Multimethod Matrix.

    ERIC Educational Resources Information Center

    Wothke, Werner

    Several multivariate statistical methodologies have been proposed to ensure objective and quantitative evaluation of the multitrait-multimethod matrix. The paper examines the performance of confirmatory factor analysis and covariance component models. It is shown, both empirically and formally, that confirmatory factor analysis is not a reliable…

  19. An algebraic factorisation scheme for spectral element solution of incompressible flow and scalar transport

    NASA Astrophysics Data System (ADS)

    Kim, Ho J.; Beskok, Ali

    2010-03-01

    A spectral element algorithm for solution of the unsteady incompressible Navier-Stokes and scalar (species/heat) transport equations is developed using the algebraic factorisation scheme. The new algorithm utilises Nth order Gauss-Lobatto-Legendre points for velocity and the scalar, while (N-2)th order Gauss-Legendre points are used for pressure. As a result, the algorithm does not require inter-element continuity for pressure and pressure boundary conditions on solid surfaces. Implementations of the algorithm are performed for conforming and non-conforming grids. The latter is accomplished using both the point-wise matching and integral projection methods, and applied for grids with both polynomial and geometric non-conformities. Code validation cases include the unsteady scalar convection equation, and Kovasznay flow in two- and three-dimensional domains. Using cases with analytical solutions, the algorithm is shown to achieve spectral accuracy in space and second-order accuracy in time. The results for the Boussinesq approximation for buoyancy-driven flows, and the species mixing in a continuous flow micro-mixer are also included as examples of applications that require long-time integration of the scalar transport equations.

  20. Modeling of 3-D Woven Ceramic Matrix Composites

    NASA Technical Reports Server (NTRS)

    Murthy, Pappu L. N.; Sullivan, Roy M.; Mital, Subodh K.

    2003-01-01

    Three different approaches are being pursued at the NASA Glenn Research Center to predict the nanostructural behavior of three-dimensional woven ceramic matrix composites. These are: a micromechanics-based approach using W-CEMCAN (Woven Ceramic Matrix Composite Analyzer), a laminate analogy method and a structural frame approach (based on the finite element method). All three techniques are applied to predict the thermomechanical properties of a three-dimensional woven angle interlock C/SiC composite. The properties are predicted for room temperature and 1100 C and the predicted properties are compared to measurements. General observations regarding the three approaches for three-dimensional composite modeling are discussed.

  1. Coulomb matrix elements in multi-orbital Hubbard models

    NASA Astrophysics Data System (ADS)

    Bünemann, Jörg; Gebhard, Florian

    2017-04-01

    Coulomb matrix elements are needed in all studies in solid-state theory that are based on Hubbard-type multi-orbital models. Due to symmetries, the matrix elements are not independent. We determine a set of independent Coulomb parameters for a d-shell and an f-shell and all point groups with up to 16 elements (O h , O, T d , T h , D 6h , and D 4h ). Furthermore, we express all other matrix elements as a function of the independent Coulomb parameters. Apart from the solution of the general point-group problem we investigate in detail the spherical approximation and first-order corrections to the spherical approximation.

  2. Matrix models and stochastic growth in Donaldson-Thomas theory

    NASA Astrophysics Data System (ADS)

    Szabo, Richard J.; Tierz, Miguel

    2012-10-01

    We show that the partition functions which enumerate Donaldson-Thomas invariants of local toric Calabi-Yau threefolds without compact divisors can be expressed in terms of specializations of the Schur measure. We also discuss the relevance of the Hall-Littlewood and Jack measures in the context of BPS state counting and study the partition functions at arbitrary points of the Kähler moduli space. This rewriting in terms of symmetric functions leads to a unitary one-matrix model representation for Donaldson-Thomas theory. We describe explicitly how this result is related to the unitary matrix model description of Chern-Simons gauge theory. This representation is used to show that the generating functions for Donaldson-Thomas invariants are related to tau-functions of the integrable Toda and Toeplitz lattice hierarchies. The matrix model also leads to an interpretation of Donaldson-Thomas theory in terms of non-intersecting paths in the lock-step model of vicious walkers. We further show that these generating functions can be interpreted as normalization constants of a corner growth/last-passage stochastic model.

  3. Matrix models and stochastic growth in Donaldson-Thomas theory

    SciTech Connect

    Szabo, Richard J.; Tierz, Miguel

    2012-10-15

    We show that the partition functions which enumerate Donaldson-Thomas invariants of local toric Calabi-Yau threefolds without compact divisors can be expressed in terms of specializations of the Schur measure. We also discuss the relevance of the Hall-Littlewood and Jack measures in the context of BPS state counting and study the partition functions at arbitrary points of the Kaehler moduli space. This rewriting in terms of symmetric functions leads to a unitary one-matrix model representation for Donaldson-Thomas theory. We describe explicitly how this result is related to the unitary matrix model description of Chern-Simons gauge theory. This representation is used to show that the generating functions for Donaldson-Thomas invariants are related to tau-functions of the integrable Toda and Toeplitz lattice hierarchies. The matrix model also leads to an interpretation of Donaldson-Thomas theory in terms of non-intersecting paths in the lock-step model of vicious walkers. We further show that these generating functions can be interpreted as normalization constants of a corner growth/last-passage stochastic model.

  4. Lie-algebraic solutions of the type IIB matrix model

    NASA Astrophysics Data System (ADS)

    Chatzistavrakidis, Athanasios

    2011-11-01

    A systematic search for Lie-algebra solutions of the type IIB matrix model is performed. Our survey is based on the classification of all Lie algebras for dimensions up to five and of all nilpotent Lie algebras of dimension six. It is shown that Lie-type solutions of the equations of motion of the type IIB matrix model exist and they correspond to certain nilpotent and solvable Lie algebras. Their representation in terms of Hermitian matrices is discussed in detail. These algebras give rise to certain noncommutative spaces for which the corresponding star products are provided. Finally the issue of constructing quantized compact nilmanifolds and solvmanifolds based on the above algebras is addressed.

  5. Using self-assembled monolayers to model the extracellular matrix.

    PubMed

    Mrksich, Milan

    2009-03-01

    The extracellular matrix is an insoluble aggregate of large proteins and glycosoaminoglycans that comprises the microenvironment of cells in tissue. The matrix displays a host of ligands that interact with cell-surface receptors to mediate the attachment and spreading of cells and regulate signaling processes. Studies of cell-matrix interactions and downstream signaling processes commonly employ substrates having an adsorbed layer of protein and are challenged by the difficulty in controlling the structure and activity of the immobilized protein. Significant effort has been directed towards the development of model substrates that present adhesion ligands in defined densities, orientations and environments. Among these approaches, self-assembled monolayers of alkanethiolates on gold offer a high level of control over the molecular structure of the surface and are well-suited to studies of cell adhesion. This review describes the design and use of monolayers for applications in cell biology, including the use of monolayers to evaluate the roles of peptide and protein ligands in cell-matrix interactions, the development of methods to pattern ligands on monolayers and applications to cell biology, the development of dynamic monolayers that can switch the activities of ligands presented to an adherent cell, and the rewiring of interactions between a cell and its substrate. These examples illustrate the flexibility inherent to monolayers for applications in cell biology.

  6. Anisotropic Damage Mechanics Modeling in Metal Matrix Composites

    DTIC Science & Technology

    1993-05-15

    conducted on a titanium aluminide SiC-reinforced metal matrix composite. Center-cracked plates with laminate layups of (0/90) and (±45). were tested...Kattan, P. I., "Finite Strain Plasticity and Damage in Constitutive Modeling of Metals with Spin Tensors," Applied Mechanics Reviews, Vol. 45, No. 3...34Contractors Meeting on Mechanics of Materials," Dayton, Ohio, October 1991. Voyiadjis, G. Z., and Kattan, P. I., "Finite Strain Plasticity and Damage in

  7. Chiral matrix model of the semi-QGP in QCD

    SciTech Connect

    Pisarski, Robert D.; Skokov, Vladimir V.

    2016-08-08

    Previously, a matrix model of the region near the transition temperature, in the “semi”quark gluon plasma, was developed for the theory of SU(3) gluons without quarks. In this paper we develop a chiral matrix model applicable to QCD by including dynamical quarks with 2+1 flavors. This requires adding a nonet of scalar fields, with both parities, and coupling these to quarks through a Yukawa coupling, y. Treating the scalar fields in mean field approximation, the effective Lagrangian is computed by integrating out quarks to one loop order. As is standard, the potential for the scalar fields is chosen to be symmetric under the flavor symmetry of SU (3)L × SU(3)R × Z (3) A , except for a term linear in the current quark mass, mqk . In addition, at a nonzero temperature T it is necessary to add a new term, ~ mqk T2 . The parameters of the gluon part of the matrix model are identical to those for the pure glue theory without quarks. The parameters in the chiral matrix model are fixed by the values, at zero temperature, of the pion decay constant and the masses of the pions, kaons, η , and η' . The temperature for the chiral crossover at T$χ$ = 155 MeV is determined by adjusting the Yukawa coupling y . We find reasonable agreement with the results of numerical simulations on the lattice for the pressure and related quantities. In the chiral limit, besides the divergence in the chiral susceptibility there is also a milder divergence in the susceptibility between the Polyakov loop and the chiral order parameter, with critical exponent β $-$ 1 . We compute derivatives with respect to a quark chemical potential to determine the susceptibilities for baryon number, the $χ$2n . Especially sensitive tests are provided by $χ$4 $-$ $χ$2 and by $χ$6 , which changes in sign about T$χ$ . In conclusion, the behavior of the susceptibilities in the chiral matrix

  8. Chiral matrix model of the semi-QGP in QCD

    DOE PAGES

    Pisarski, Robert D.; Skokov, Vladimir V.

    2016-08-08

    Previously, a matrix model of the region near the transition temperature, in the “semi”quark gluon plasma, was developed for the theory of SU(3) gluons without quarks. In this paper we develop a chiral matrix model applicable to QCD by including dynamical quarks with 2+1 flavors. This requires adding a nonet of scalar fields, with both parities, and coupling these to quarks through a Yukawa coupling, y. Treating the scalar fields in mean field approximation, the effective Lagrangian is computed by integrating out quarks to one loop order. As is standard, the potential for the scalar fields is chosen to bemore » symmetric under the flavor symmetry of SU (3)L × SU(3)R × Z (3) A , except for a term linear in the current quark mass, mqk . In addition, at a nonzero temperature T it is necessary to add a new term, ~ mqk T2 . The parameters of the gluon part of the matrix model are identical to those for the pure glue theory without quarks. The parameters in the chiral matrix model are fixed by the values, at zero temperature, of the pion decay constant and the masses of the pions, kaons, η , and η' . The temperature for the chiral crossover at T$χ$ = 155 MeV is determined by adjusting the Yukawa coupling y . We find reasonable agreement with the results of numerical simulations on the lattice for the pressure and related quantities. In the chiral limit, besides the divergence in the chiral susceptibility there is also a milder divergence in the susceptibility between the Polyakov loop and the chiral order parameter, with critical exponent β $-$ 1 . We compute derivatives with respect to a quark chemical potential to determine the susceptibilities for baryon number, the $χ$2n . Especially sensitive tests are provided by $χ$4 $-$ $χ$2 and by $χ$6 , which changes in sign about T$χ$ . In conclusion, the behavior of the susceptibilities in the chiral matrix model strongly suggests that as the temperature increases from T$χ$ , that the transition to

  9. Chiral matrix model of the semi-QGP in QCD

    NASA Astrophysics Data System (ADS)

    Pisarski, Robert D.; Skokov, Vladimir V.

    2016-08-01

    Previously, a matrix model of the region near the transition temperature, in the "semi"quark gluon plasma, was developed for the theory of S U (3 ) gluons without quarks. In this paper we develop a chiral matrix model applicable to QCD by including dynamical quarks with 2 +1 flavors. This requires adding a nonet of scalar fields, with both parities, and coupling these to quarks through a Yukawa coupling, y . Treating the scalar fields in mean field approximation, the effective Lagrangian is computed by integrating out quarks to one loop order. As is standard, the potential for the scalar fields is chosen to be symmetric under the flavor symmetry of S U (3 )L×S U (3 )R×Z (3 )A, except for a term linear in the current quark mass, mqk. In addition, at a nonzero temperature T it is necessary to add a new term, ˜mqkT2. The parameters of the gluon part of the matrix model are identical to those for the pure glue theory without quarks. The parameters in the chiral matrix model are fixed by the values, at zero temperature, of the pion decay constant and the masses of the pions, kaons, η , and η'. The temperature for the chiral crossover at Tχ=155 MeV is determined by adjusting the Yukawa coupling y . We find reasonable agreement with the results of numerical simulations on the lattice for the pressure and related quantities. In the chiral limit, besides the divergence in the chiral susceptibility there is also a milder divergence in the susceptibility between the Polyakov loop and the chiral order parameter, with critical exponent β -1 . We compute derivatives with respect to a quark chemical potential to determine the susceptibilities for baryon number, the χ2 n. Especially sensitive tests are provided by χ4-χ2 and by χ6, which changes in sign about Tχ. The behavior of the susceptibilities in the chiral matrix model strongly suggests that as the temperature increases from Tχ, that the transition to deconfinement is significantly quicker than indicated by the

  10. Modeling mechanophore activation within a crosslinked glassy matrix

    NASA Astrophysics Data System (ADS)

    Silberstein, Meredith N.; Min, Kyoungmin; Cremar, Lee D.; Degen, Cassandra M.; Martinez, Todd J.; Aluru, Narayana R.; White, Scott R.; Sottos, Nancy R.

    2013-07-01

    Mechanically induced reactivity is a promising means for designing self-reporting materials. Mechanically sensitive chemical groups called mechanophores are covalently linked into polymers in order to trigger specific chemical reactions upon mechanical loading. These mechanophores can be linked either within the backbone or as crosslinks between backbone segments. Mechanophore response is sensitive to both the matrix properties and placement within the matrix, providing two avenues for material design. A model framework is developed to describe reactivity of mechanophores located as crosslinks in a glassy polymer matrix. Simulations are conducted at the molecular and macromolecular scales in order to develop macroscale constitutive relations. The model is developed specifically for the case of spiropyran (SP) in lightly crosslinked polymethylmethacrylate (PMMA). This optically trackable mechanophore (fluorescent when activated) allows the model to be assessed in terms of observed experimental behavior. The force modified potential energy surface (FMPES) framework is used in conjunction with ab initio steered molecular dynamics (MD) simulations of SP to determine the mechanophore kinetics. MD simulations of the crosslinked PMMA structure under shear deformation are used to determine the relationship between macroscale stress and local force on the crosslinks. A continuum model implemented in a finite element framework synthesizes these mechanochemical relations with the mechanical behavior. The continuum model with parameters taken directly from the FMPES and MD analyses under predicts stress-driven activation relative to experimental data. The continuum model, with the physically motivated modification of force fluctuations, provides an accurate prediction for monotonic loading across three decades of strain rate and creep loading, suggesting that the fundamental physics are captured.

  11. Mechanical model for a collagen fibril pair in extracellular matrix.

    PubMed

    Chan, Yue; Cox, Grant M; Haverkamp, Richard G; Hill, James M

    2009-04-01

    In this paper, we model the mechanics of a collagen pair in the connective tissue extracellular matrix that exists in abundance throughout animals, including the human body. This connective tissue comprises repeated units of two main structures, namely collagens as well as axial, parallel and regular anionic glycosaminoglycan between collagens. The collagen fibril can be modeled by Hooke's law whereas anionic glycosaminoglycan behaves more like a rubber-band rod and as such can be better modeled by the worm-like chain model. While both computer simulations and continuum mechanics models have been investigated for the behavior of this connective tissue typically, authors either assume a simple form of the molecular potential energy or entirely ignore the microscopic structure of the connective tissue. Here, we apply basic physical methodologies and simple applied mathematical modeling techniques to describe the collagen pair quantitatively. We found that the growth of fibrils was intimately related to the maximum length of the anionic glycosaminoglycan and the relative displacement of two adjacent fibrils, which in return was closely related to the effectiveness of anionic glycosaminoglycan in transmitting forces between fibrils. These reveal the importance of the anionic glycosaminoglycan in maintaining the structural shape of the connective tissue extracellular matrix and eventually the shape modulus of human tissues. We also found that some macroscopic properties, like the maximum molecular energy and the breaking fraction of the collagen, were also related to the microscopic characteristics of the anionic glycosaminoglycan.

  12. Matrix viscoplasticity and its shielding by active mechanics in microtissue models: experiments and mathematical modeling

    NASA Astrophysics Data System (ADS)

    Liu, Alan S.; Wang, Hailong; Copeland, Craig R.; Chen, Christopher S.; Shenoy, Vivek B.; Reich, Daniel H.

    2016-09-01

    The biomechanical behavior of tissues under mechanical stimulation is critically important to physiological function. We report a combined experimental and modeling study of bioengineered 3D smooth muscle microtissues that reveals a previously unappreciated interaction between active cell mechanics and the viscoplastic properties of the extracellular matrix. The microtissues’ response to stretch/unstretch actuations, as probed by microcantilever force sensors, was dominated by cellular actomyosin dynamics. However, cell lysis revealed a viscoplastic response of the underlying model collagen/fibrin matrix. A model coupling Hill-type actomyosin dynamics with a plastic perfectly viscoplastic description of the matrix quantitatively accounts for the microtissue dynamics, including notably the cells’ shielding of the matrix plasticity. Stretch measurements of single cells confirmed the active cell dynamics, and were well described by a single-cell version of our model. These results reveal the need for new focus on matrix plasticity and its interactions with active cell mechanics in describing tissue dynamics.

  13. Matrix viscoplasticity and its shielding by active mechanics in microtissue models: experiments and mathematical modeling

    PubMed Central

    Liu, Alan S.; Wang, Hailong; Copeland, Craig R.; Chen, Christopher S.; Shenoy, Vivek B.; Reich, Daniel H.

    2016-01-01

    The biomechanical behavior of tissues under mechanical stimulation is critically important to physiological function. We report a combined experimental and modeling study of bioengineered 3D smooth muscle microtissues that reveals a previously unappreciated interaction between active cell mechanics and the viscoplastic properties of the extracellular matrix. The microtissues’ response to stretch/unstretch actuations, as probed by microcantilever force sensors, was dominated by cellular actomyosin dynamics. However, cell lysis revealed a viscoplastic response of the underlying model collagen/fibrin matrix. A model coupling Hill-type actomyosin dynamics with a plastic perfectly viscoplastic description of the matrix quantitatively accounts for the microtissue dynamics, including notably the cells’ shielding of the matrix plasticity. Stretch measurements of single cells confirmed the active cell dynamics, and were well described by a single-cell version of our model. These results reveal the need for new focus on matrix plasticity and its interactions with active cell mechanics in describing tissue dynamics. PMID:27671239

  14. Chaos in matrix models and black hole evaporation

    NASA Astrophysics Data System (ADS)

    Berkowitz, Evan; Hanada, Masanori; Maltz, Jonathan

    2016-12-01

    Is the evaporation of a black hole described by a unitary theory? In order to shed light on this question—especially aspects of this question such as a black hole's negative specific heat—we consider the real-time dynamics of a solitonic object in matrix quantum mechanics, which can be interpreted as a black hole (black zero-brane) via holography. We point out that the chaotic nature of the system combined with the flat directions of its potential naturally leads to the emission of D0-branes from the black brane, which is suppressed in the large N limit. Simple arguments show that the black zero-brane, like the Schwarzschild black hole, has negative specific heat, in the sense that the temperature goes up when it evaporates by emitting D0-branes. While the largest Lyapunov exponent grows during the evaporation, the Kolmogorov-Sinai entropy decreases. These are consequences of the generic properties of matrix models and gauge theory. Based on these results, we give a possible geometric interpretation of the eigenvalue distribution of matrices in terms of gravity. Applying the same argument in the M-theory parameter region, we provide a scenario to derive the Hawking radiation of massless particles from the Schwarzschild black hole. Finally, we suggest that by adding a fraction of the quantum effects to the classical theory, we can obtain a matrix model whose classical time evolution mimics the entire life of the black brane, from its formation to the evaporation.

  15. Thermal response model of polymer matrix composites under laser irradiating

    NASA Astrophysics Data System (ADS)

    Peng, Guo-liang; Zhang, Xiang-hua; Du, Tai-jiao

    2015-05-01

    A numerical study is conducted to determine which model could be used to compute temperature fields of polymer matrix composites under laser irradiating. By using the local thermal non-equilibrium model, solid and gas temperature on surfaces of materials with different volume convection coefficients have been computed and compared under different heat flux. The results show that the assumption of local thermal equilibrium is not reasonable until the heat flux applied to composites is low enough and the volume convection coefficient is big enough. And the gas may be not important for solid temperature when the volume convection coefficient is small.

  16. Matrix population models from 20 studies of perennial plant populations

    USGS Publications Warehouse

    Ellis, Martha M.; Williams, Jennifer L.; Lesica, Peter; Bell, Timothy J.; Bierzychudek, Paulette; Bowles, Marlin; Crone, Elizabeth E.; Doak, Daniel F.; Ehrlen, Johan; Ellis-Adam, Albertine; McEachern, Kathryn; Ganesan, Rengaian; Latham, Penelope; Luijten, Sheila; Kaye, Thomas N.; Knight, Tiffany M.; Menges, Eric S.; Morris, William F.; den Nijs, Hans; Oostermeijer, Gerard; Quintana-Ascencio, Pedro F.; Shelly, J. Stephen; Stanley, Amanda; Thorpe, Andrea; Tamara, Ticktin; Valverde, Teresa; Weekley, Carl W.

    2012-01-01

    Demographic transition matrices are one of the most commonly applied population models for both basic and applied ecological research. The relatively simple framework of these models and simple, easily interpretable summary statistics they produce have prompted the wide use of these models across an exceptionally broad range of taxa. Here, we provide annual transition matrices and observed stage structures/population sizes for 20 perennial plant species which have been the focal species for long-term demographic monitoring. These data were assembled as part of the "Testing Matrix Models" working group through the National Center for Ecological Analysis and Synthesis (NCEAS). In sum, these data represent 82 populations with >460 total population-years of data. It is our hope that making these data available will help promote and improve our ability to monitor and understand plant population dynamics.

  17. Matrix population models from 20 studies of perennial plant populations

    USGS Publications Warehouse

    Ellis, Martha M.; Williams, Jennifer L.; Lesica, Peter; Bell, Timothy J.; Bierzychudek, Paulette; Bowles, Marlin; Crone, Elizabeth E.; Doak, Daniel F.; Ehrlen, Johan; Ellis-Adam, Albertine; McEachern, Kathryn; Ganesan, Rengaian; Latham, Penelope; Luijten, Sheila; Kaye, Thomas N.; Knight, Tiffany M.; Menges, Eric S.; Morris, William F.; den Nijs, Hans; Oostermeijer, Gerard; Quintana-Ascencio, Pedro F.; Shelly, J. Stephen; Stanley, Amanda; Thorpe, Andrea; Tamara, Ticktin; Valverde, Teresa; Weekley, Carl W.

    2012-01-01

    Demographic transition matrices are one of the most commonly applied population models for both basic and applied ecological research. The relatively simple framework of these models and simple, easily interpretable summary statistics they produce have prompted the wide use of these models across an exceptionally broad range of taxa. Here, we provide annual transition matrices and observed stage structures/population sizes for 20 perennial plant species which have been the focal species for long-term demographic monitoring. These data were assembled as part of the 'Testing Matrix Models' working group through the National Center for Ecological Analysis and Synthesis (NCEAS). In sum, these data represent 82 populations with >460 total population-years of data. It is our hope that making these data available will help promote and improve our ability to monitor and understand plant population dynamics.

  18. An Uncertainty Structure Matrix for Models and Simulations

    NASA Technical Reports Server (NTRS)

    Green, Lawrence L.; Blattnig, Steve R.; Hemsch, Michael J.; Luckring, James M.; Tripathi, Ram K.

    2008-01-01

    Software that is used for aerospace flight control and to display information to pilots and crew is expected to be correct and credible at all times. This type of software is typically developed under strict management processes, which are intended to reduce defects in the software product. However, modeling and simulation (M&S) software may exhibit varying degrees of correctness and credibility, depending on a large and complex set of factors. These factors include its intended use, the known physics and numerical approximations within the M&S, and the referent data set against which the M&S correctness is compared. The correctness and credibility of an M&S effort is closely correlated to the uncertainty management (UM) practices that are applied to the M&S effort. This paper describes an uncertainty structure matrix for M&S, which provides a set of objective descriptions for the possible states of UM practices within a given M&S effort. The columns in the uncertainty structure matrix contain UM elements or practices that are common across most M&S efforts, and the rows describe the potential levels of achievement in each of the elements. A practitioner can quickly look at the matrix to determine where an M&S effort falls based on a common set of UM practices that are described in absolute terms that can be applied to virtually any M&S effort. The matrix can also be used to plan those steps and resources that would be needed to improve the UM practices for a given M&S effort.

  19. The multitrace matrix model: An alternative to Connes NCG and IKKT model in 2 dimensions

    NASA Astrophysics Data System (ADS)

    Ydri, Badis

    2016-12-01

    We present a new multitrace matrix model, which is a generalization of the real quartic one matrix model, exhibiting dynamical emergence of a fuzzy two-sphere and its non-commutative gauge theory. This provides a novel and a much simpler alternative to Connes non-commutative geometry and to the IKKT matrix model for emergent geometry in two dimensions. However, in higher dimensions this mechanism is not known to exist and the systematic frameworks of NCG and IKKT are expected to hold sway.

  20. Modeling of cumulative tool wear in machining metal matrix composites

    SciTech Connect

    Hung, N.P.; Tan, V.K.; Oon, B.E.

    1995-12-31

    Metal matrix composites (MMCs) are notoriously known for their low machinability because of the abrasive and brittle reinforcement. Although a near-net-shape product could be produced, finish machining is still required for the final shape and dimension. The classical Taylor`s tool life equation that relates tool life and cutting conditions has been traditionally used to study machinability. The turning operation is commonly used to investigate the machinability of a material; tedious and costly milling experiments have to be performed separately; while a facing test is not applicable for the Taylor`s model since the facing speed varies as the tool moves radially. Collecting intensive machining data for MMCs is often difficult because of the constraints on size, cost of the material, and the availability of sophisticated machine tools. A more flexible model and machinability testing technique are, therefore, sought. This study presents and verifies new models for turning, facing, and milling operations. Different cutting conditions were utilized to assess the machinability of MMCs reinforced with silicon carbide or alumina particles. Experimental data show that tool wear does not depend on the order of different cutting speeds since abrasion is the main wear mechanism. Correlation between data for turning, milling, and facing is presented. It is more economical to rank machinability using data for facing and then to convert the data for turning and milling, if required. Subsurface damages such as work-hardened and cracked matrix alloy, and fractured and delaminated particles are discussed.

  1. Non-Hermitian random matrix models: Free random variable approach

    SciTech Connect

    Janik, R.A.,; Nowak, M.A., ||; Papp, G.,; Wambach, J.,; Zahed, I., |

    1997-04-01

    Using the standard concepts of free random variables, we show that for a large class of non-Hermitian random matrix models, the support of the eigenvalue distribution follows from their Hermitian analogs using a conformal transformation. We also extend the concepts of free random variables to the class of non-Hermitian matrices, and apply them to the models discussed by Ginibre-Girko (elliptic ensemble) [J. Ginibre, J. Math. Phys. {bold 6}, 1440 (1965); V. L. Girko, {ital Spectral Theory of Random Matrices} (in Russian) (Nauka, Moscow, 1988)] and Mahaux-Weidenm{umlt u}ller (chaotic resonance scattering) [C. Mahaux and H. A. Weidenm{umlt u}ller, {ital Shell-model Approach to Nuclear Reactions} (North-Holland, Amsterdam, 1969)]. {copyright} {ital 1997} {ital The American Physical Society}

  2. The implementation of holography in the plane wave matrix model

    NASA Astrophysics Data System (ADS)

    Mints, Aleksey Leonidovich

    It is expected that at the core of nonperturbative theories of quantum gravity, such as M-theory, lies the realization of the holographic principle, in the sense that a holographic theory should contain one binary degree of freedom per Planck area. Present understanding of such theories requires the holographic encoding of bulk data in large matrices. Currently this mapping is poorly understood. The plane wave matrix model provides a laboratory for isolating aspects of this problem in a controlled setting. At large boosts, configurations of concentric membranes become superselection sectors, whose exact spectra are known. From the bulk point of view one expects product states of individual membranes to be contained within the full spectrum. However, for non-BPS states this inclusion relation is obscured by Gauss law constraints. Its validity rests on nontrivial relations in representation theory, which we identify and verify by explicit computation. Beyond the decoding and partial identification of selected states in large matrices, one would like to get a better understanding of the holographic state counting of these degrees of freedom, i.e., entropy. Contrary to the naive expectation of holography realized in terms of the covariant entropy bound, we present evidence that it is the Bekenstein entropy bound, which is related to area differences, that is manifest in the plane wave matrix model. If holography is implemented in this way, we predict crossover behavior at strong coupling when the energy exceeds N2 in units of the mass scale.

  3. Teaching Improvement Model Designed with DEA Method and Management Matrix

    ERIC Educational Resources Information Center

    Montoneri, Bernard

    2014-01-01

    This study uses student evaluation of teachers to design a teaching improvement matrix based on teaching efficiency and performance by combining management matrix and data envelopment analysis. This matrix is designed to formulate suggestions to improve teaching. The research sample consists of 42 classes of freshmen following a course of English…

  4. Hygrothermal modeling and testing of polymers and polymer matrix composites

    NASA Astrophysics Data System (ADS)

    Xu, Weiqun

    2000-10-01

    The dissertation, consisting of four papers, presents the results of the research investigation on environmental effects on polymers and polymer matrix composites. Hygrothermal models were developed that would allow characterization of non-Fickian diffusion coefficients from moisture weight gain data. Hygrothermal testing was also conducted to provide the necessary data for characterizing of model coefficients and model verification. In part 1, a methodology is proposed that would allow characterization of non-Fickian diffusion coefficients from moisture weight gain data for a polymer adhesive below its Tg. Subsequently, these diffusion coefficients are used for predicting moisture concentration profiles through the thickness of a polymer. In part 2, a modeling methodology based on irreversible thermodynamics applied within the framework of composite macro-mechanics is presented, that would allow characterization of non-Fickian diffusion coefficients from moisture weight gain data for laminated composites with distributed uniaxial damage. Comparisons with test data for a 5-harness satin textile composite with uniaxial micro-cracks are provided for model verifications. In part 3, the same modeling methodology based on irreversible thermodynamics is extended to the case of a bi-axially damaged laminate. The model allows characterization of nonFickian diffusion coefficients as well as moisture saturation level from moisture weight gain data for laminates with pre-existing damage. Comparisons with test data for a bi-axially damaged Graphite/Epoxy woven composite are provided for model verifications. Finally, in part 4, hygrothermal tests conducted on AS4/PR500 5HS textile composite laminates are summarized. The objectives of the hygrothermal tests are to determine the diffusivity and maximum moisture content of the laminate.

  5. Phase Transitions and Equilibrium Measures in Random Matrix Models

    NASA Astrophysics Data System (ADS)

    Martínez-Finkelshtein, A.; Orive, R.; Rakhmanov, E. A.

    2015-02-01

    The paper is devoted to a study of phase transitions in the Hermitian random matrix models with a polynomial potential. In an alternative equivalent language, we study families of equilibrium measures on the real line in a polynomial external field. The total mass of the measure is considered as the main parameter, which may be interpreted also either as temperature or time. Our main tools are differentiation formulas with respect to the parameters of the problem, and a representation of the equilibrium potential in terms of a hyperelliptic integral. Using this combination we introduce and investigate a dynamical system (system of ODEs) describing the evolution of families of equilibrium measures. On this basis we are able to systematically derive a number of new results on phase transitions, such as the local behavior of the system at all kinds of phase transitions, as well as to review a number of known ones.

  6. A matrix model for Misner universe and closed string tachyons

    NASA Astrophysics Data System (ADS)

    She, Jian-Huang

    2006-01-01

    We use D-instantons to probe the geometry of Misner universe, and calculate the world volume field theory action, which is of the 1+0 dimensional form and highly non-local. Turning on closed string tachyons, we see from the deformed moduli space of the D-instantons that the spacelike singularity is removed and the region near the singularity becomes a fuzzy cone, where space and time do not commute. When realized cosmologically there can be controllable trans-planckian effects. And the infinite past is now causally connected with the infinite future, thus also providing a model for big crunch/big bang transition. In the spirit of IKKT matrix theory, we propose that the D-instanton action here provides a holographic description for Misner universe and time is generated dynamically. In addition we show that winding string production from the vacua and instability of D-branes have simple uniform interpretations in this second quantized formalism.

  7. Higher Rank ABJM Wilson Loops from Matrix Models

    NASA Astrophysics Data System (ADS)

    Cookmeyer, Jonathan; Liu, James; Zayas, Leopoldo

    2017-01-01

    We compute the expectation values of 1/6 supersymmetric Wilson Loops in ABJM theory in higher rank representations. Using standard matrix model techniques, we calculate the expectation value in the rank m fully symmetric and fully antisymmetric representation where m is scaled with N. To leading order, we find agreement with the classical action of D6 and D2 branes in AdS4 ×CP3 respectively. Further, we compute the first subleading order term, which, on the AdS side, makes a prediction for the one-loop effective action of the corresponding D6 and D2 branes. Supported by the National Science Foundation under Grant No. PHY 1559988 and the US Department of Energy under Grant No. DE-SC0007859.

  8. Modeling Woven Polymer Matrix Composites with MAC/GMC

    NASA Technical Reports Server (NTRS)

    Bednarcyk, Brett A.; Arnold, Steven M. (Technical Monitor)

    2000-01-01

    NASA's Micromechanics Analysis Code with Generalized Method of Cells (MAC/GMC) is used to predict the elastic properties of plain weave polymer matrix composites (PMCs). The traditional one step three-dimensional homogertization procedure that has been used in conjunction with MAC/GMC for modeling woven composites in the past is inaccurate due to the lack of shear coupling inherent to the model. However, by performing a two step homogenization procedure in which the woven composite repeating unit cell is homogenized independently in the through-thickness direction prior to homogenization in the plane of the weave, MAC/GMC can now accurately model woven PMCs. This two step procedure is outlined and implemented, and predictions are compared with results from the traditional one step approach and other models and experiments from the literature. Full coupling of this two step technique with MAC/ GMC will result in a widely applicable, efficient, and accurate tool for the design and analysis of woven composite materials and structures.

  9. Analytical Model of Water Flow in Coal with Active Matrix

    NASA Astrophysics Data System (ADS)

    Siemek, Jakub; Stopa, Jerzy

    2014-12-01

    This paper presents new analytical model of gas-water flow in coal seams in one dimension with emphasis on interactions between water flowing in cleats and coal matrix. Coal as a flowing system, can be viewed as a solid organic material consisting of two flow subsystems: a microporous matrix and a system of interconnected macropores and fractures. Most of gas is accumulated in the microporous matrix, where the primary flow mechanism is diffusion. Fractures and cleats existing in coal play an important role as a transportation system for macro scale flow of water and gas governed by Darcy's law. The coal matrix can imbibe water under capillary forces leading to exchange of mass between fractures and coal matrix. In this paper new partial differential equation for water saturation in fractures has been formulated, respecting mass exchange between coal matrix and fractures. Exact analytical solution has been obtained using the method of characteristics. The final solution has very simple form that may be useful for practical engineering calculations. It was observed that the rate of exchange of mass between the fractures and the coal matrix is governed by an expression which is analogous to the Newton cooling law known from theory of heat exchange, but in present case the mass transfer coefficient depends not only on coal and fluid properties but also on time and position. The constant term of mass transfer coefficient depends on relation between micro porosity and macro porosity of coal, capillary forces, and microporous structure of coal matrix. This term can be expressed theoretically or obtained experimentally. W artykule zaprezentowano nowy model matematyczny przepływu wody i gazu w jednowymiarowej warstwie węglowej z uwzględnieniem wymiany masy między systemem szczelin i matrycą węglową. Węgiel jako system przepływowy traktowany jest jako układ o podwójnej porowatości i przepuszczalności, składający się z mikroporowatej matrycy węglowej oraz z

  10. Filter-matrix lattice Boltzmann model for microchannel gas flows.

    PubMed

    Zhuo, Congshan; Zhong, Chengwen

    2013-11-01

    The lattice Boltzmann method has been shown to be successful for microscale gas flows, and it has attracted significant research interest. In this paper, the recently proposed filter-matrix lattice Boltzmann (FMLB) model is first applied to study the microchannel gas flows, in which a Bosanquet-type effective viscosity is used to capture the flow behaviors in the transition regime. A kinetic boundary condition, the combined bounce-back and specular-reflection scheme with the second-order slip scheme, is also designed for the FMLB model. By analyzing a unidirectional flow, the slip velocity and the discrete effects related to the boundary condition are derived within the FMLB model, and a revised scheme is presented to overcome such effects, which have also been validated through numerical simulations. To gain an accurate simulation in a wide range of Knudsen numbers, covering the slip and the entire transition flow regimes, a set of slip coefficients with an introduced fitting function is adopted in the revised second-order slip boundary condition. The periodic and pressure-driven microchannel flows have been investigated by the present model in this study. The numerical results, including the velocity profile and the mass flow rate, as well as the nonlinear pressure distribution along the channel, agree fairly well with the solutions of the linearized Boltzmann equation, the direct simulation Monte Carlo results, the experimental data, and the previous results of the multiple effective relaxation lattice Boltzmann model. Also, the present results of the velocity profile and the mass flow rate show that the present model with the fitting function can yield improved predictions for the microchannel gas flow with higher Knudsen numbers in the transition flow regime.

  11. Simulating generic spin-boson models with matrix product states

    NASA Astrophysics Data System (ADS)

    Wall, Michael L.; Safavi-Naini, Arghavan; Rey, Ana Maria

    2016-11-01

    The global coupling of few-level quantum systems ("spins") to a discrete set of bosonic modes is a key ingredient for many applications in quantum science, including large-scale entanglement generation, quantum simulation of the dynamics of long-range interacting spin models, and hybrid platforms for force and spin sensing. We present a general numerical framework for treating the out-of-equilibrium dynamics of such models based on matrix product states. Our approach applies for generic spin-boson systems: it treats any spatial and operator dependence of the two-body spin-boson coupling and places no restrictions on relative energy scales. We show that the full counting statistics of collective spin measurements and infidelity of quantum simulation due to spin-boson entanglement, both of which are difficult to obtain by other techniques, are readily calculable in our approach. We benchmark our method using a recently developed exact solution for a particular spin-boson coupling relevant to trapped ion quantum simulators. Finally, we show how decoherence can be incorporated within our framework using the method of quantum trajectories, and study the dynamics of an open-system spin-boson model with spatially nonuniform spin-boson coupling relevant for trapped atomic ion crystals in the presence of molecular ion impurities.

  12. Assessing Fit of Item Response Models Using the Information Matrix Test

    ERIC Educational Resources Information Center

    Ranger, Jochen; Kuhn, Jorg-Tobias

    2012-01-01

    The information matrix can equivalently be determined via the expectation of the Hessian matrix or the expectation of the outer product of the score vector. The identity of these two matrices, however, is only valid in case of a correctly specified model. Therefore, differences between the two versions of the observed information matrix indicate…

  13. Model of the Human Eye Based on ABCD Matrix

    NASA Astrophysics Data System (ADS)

    González, G. Díaz; Castillo, M. David Iturbe

    2008-04-01

    At the moment several models of the human eye exist, nevertheless the gradient index models of the human lens (crystalline) have received little attention in optometry and vision sciences, although they consider how the refractive index and the refracting power can change with the accommodation. On the other hand, in study fields like ophthalmology and optometry, exist cases where there is a lack of information about the factors that influence the change of refractive power and therefore the focal length of the eye. By such reason, in this paper we present a model of the human eye based on the ABCD matrix in order to describe the propagation of light rays, that can be understood by professional people in optics, ophthalmology and optometry, and the dispersions of the different ocular mediums are taken into account,. The aim of the model is to obtain data about the refractive power of the eye under different considerations, such as: changes in wavelength, radius of curvature and thicknesses of the ocular mediums. We present results of simulations in Matlab of our model, assuming that the object is punctual and is placed to a certain distance of the eye, and considering at the beginning to the crystalline like a medium with fixed refractive index, and after like a gradient lens. By means of graphs, we show the total refractive power of the eye and its form and type of dependence with respect to variations in radius of curvature and thicknesses of the cornea and crystalline, as well as variations in the thickness of the previous and later cameras.

  14. Simulating spin-boson models with matrix product states

    NASA Astrophysics Data System (ADS)

    Wall, Michael; Safavi-Naini, Arghavan; Rey, Ana Maria

    2016-05-01

    The global coupling of few-level quantum systems (``spins'') to a discrete set of bosonic modes is a key ingredient for many applications in quantum science, including large-scale entanglement generation, quantum simulation of the dynamics of long-range interacting spin models, and hybrid platforms for force and spin sensing. In many situations, the bosons are integrated out, leading to effective long-range interactions between the spins; however, strong spin-boson coupling invalidates this approach, and spin-boson entanglement degrades the fidelity of quantum simulation of spin models. We present a general numerical method for treating the out-of-equilibrium dynamics of spin-boson systems based on matrix product states. While most efficient for weak coupling or small numbers of boson modes, our method applies for any spatial and operator dependence of the spin-boson coupling. In addition, our approach allows straightforward computation of many quantities of interest, such as the full counting statistics of collective spin measurements and quantum simulation infidelity due to spin-boson entanglement. We apply our method to ongoing trapped ion quantum simulator experiments in analytically intractable regimes. This work is supported by JILA-NSF-PFC-1125844, NSF-PIF- 1211914, ARO, AFOSR, AFOSR-MURI, and the NRC.

  15. A discrete approach for modeling cell-matrix adhesions

    NASA Astrophysics Data System (ADS)

    Escribano, J.; Sánchez, M. T.; García-Aznar, J. M.

    2014-06-01

    During recent years the interaction between the extracellular matrix and the cytoskeleton of the cell has been object of numerous studies due to its importance in cell migration processes. These interactions are performed through protein clutches, known as focal adhesions. For migratory cells these focal adhesions along with force generating processes in the cytoskeleton are responsible for the formation of protrusion structures like lamellipodia or filopodia. Much is known about these structures: the different proteins that conform them, the players involved in their formation or their role in cell migration. Concretely, growth-cone filopodia structures have attracted significant attention because of their role as cell sensors of their surrounding environment and its complex behavior. On this matter, a vast myriad of mathematical models has been presented to explain its mechanical behavior. In this work, we aim to study the mechanical behavior of these structures through a discrete approach. This numerical model provides an individual analysis of the proteins involved including spatial distribution, interaction between them, and study of different phenomena, such as clutches unbinding or protein unfolding.

  16. Scalar products in GL(3)-based models with trigonometric R-matrix. Determinant representation

    NASA Astrophysics Data System (ADS)

    Slavnov, N. A.

    2015-03-01

    We study quantum integrable GL(3)-based models with a trigonometric R-matrix solvable by the nested algebraic Bethe ansatz. We derive a determinant representation for a special case of scalar products of Bethe vectors. This representation allows one to find a determinant formula for the form factor of one of the monodromy matrix entries. We also point out an essential difference between form factors in the models with the trigonometric R-matrix and their analogs in GL(3)-invariant models.

  17. Physical model of differential Mueller matrix for depolarizing uniform media.

    PubMed

    Devlaminck, Vincent

    2013-11-01

    In this article, we address the question of significance of the parameters of differential Mueller matrix formalism. We show how the concept of mean value and uncertainty of the optical properties recently introduced to depict this differential matrix can be related to the random fluctuations of these optical properties. From the layered-medium interpretation introduced by Jones [J. Opt. Soc. Am. 38, 671 (1948)] and extended to Mueller-Jones matrix by Azzam [J. Opt. Soc. Am. 68, 1756 (1978)], a generalization to depolarizing Mueller matrices is proposed. Based on the random Mueller-Jones matrix approach, the obtained parameterization perfectly fits the previous results from the literature. Necessary conditions of positivity on specific coefficients imposed in order to have physical Mueller matrix are introduced in a natural way and not inferred a posteriori. Interpretations of the underlying physical processes are also presented. An illustrative experimental example is provided from literature data.

  18. Significance of matrix diagonalization in modelling inelastic electron scattering.

    PubMed

    Lee, Z; Hambach, R; Kaiser, U; Rose, H

    2016-11-21

    Electron scattering is always applied as one of the routines to investigate nanostructures. Nowadays the development of hardware offers more and more prospect for this technique. For example imaging nanostructures with inelastic scattered electrons may allow to produce component-sensitive images with atomic resolution. Modelling inelastic electron scattering is therefore essential for interpreting these images. The main obstacle to study inelastic scattering problem is its complexity. During inelastic scattering, incident electrons entangle with objects, and the description of this process involves a multidimensional array. Since the simulation usually involves fourdimensional Fourier transforms, the computation is highly inefficient. In this work we have offered one solution to handle the multidimensional problem. By transforming a high dimensional array into twodimensional array, we are able to perform matrix diagonalization and approximate the original multidimensional array with its twodimensional eigenvectors. Our procedure reduces the complicated multidimensional problem to a twodimensional problem. In addition, it minimizes the number of twodimensional problems. This method is very useful for studying multiple inelastic scattering.

  19. Matrix product states and the non-Abelian rotor model

    NASA Astrophysics Data System (ADS)

    Milsted, Ashley

    2016-04-01

    We use uniform matrix product states to study the (1 +1 )D O (2 ) and O (4 ) rotor models, which are equivalent to the Kogut-Susskind formulation of matter-free non-Abelian lattice gauge theory on a "Hawaiian earring" graph for U (1 ) and S U (2 ), respectively. Applying tangent space methods to obtain ground states and determine the mass gap and the β function, we find excellent agreement with known results, locating the Berezinskii-Kosterlitz-Thouless transition for O (2 ) and successfully entering the asymptotic weak-coupling regime for O (4 ). To obtain a finite local Hilbert space, we truncate in the space of generalized Fourier modes of the gauge group, comparing the effects of different cutoff values. We find that higher modes become important in the crossover and weak-coupling regimes of the non-Abelian theory, where entanglement also suddenly increases. This could have important consequences for tensor network state studies of Yang-Mills on higher-dimensional graphs.

  20. Neutrinoless Double Beta Nuclear Matrix Elements Around Mass 80 in the Nuclear Shell Model

    NASA Astrophysics Data System (ADS)

    Yoshinaga, Naotaka; Higashiyama, Koji; Taguchi, Daisuke; Teruya, Eri

    The observation of the neutrinoless double-beta decay can determine whether the neutrino is a Majorana particle or not. In its theoretical nuclear side it is particularly important to estimate three types of nuclear matrix elements, namely, Fermi (F), Gamow-Teller (GT), and tensor (T) types matrix elements. The shell model calculations and also the pair-truncated shell model calculations are carried out to check the model dependence on nuclear matrix elements. In this work the neutrinoless double-beta decay for mass A = 82 nuclei is studied. It is found that the matrix elements are quite sensitive to the ground state wavefunctions.

  1. Modeling Background Attenuation by Sample Matrix in Gamma Spectrometric Analyses

    SciTech Connect

    Bastos, Rodrigo O.; Appoloni, Carlos R.

    2008-08-07

    In laboratory gamma spectrometric analyses, the procedures for estimating background usually overestimate it. If an empty container similar to that used to hold samples is measured, it does not consider the background attenuation by sample matrix. If a 'blank' sample is measured, the hypothesis that this sample will be free of radionuclides is generally not true. The activity of this 'blank' sample is frequently sufficient to mask or to overwhelm the effect of attenuation so that the background remains overestimated. In order to overcome this problem, a model was developed to obtain the attenuated background from the spectrum acquired with the empty container. Beyond reasonable hypotheses, the model presumes the knowledge of the linear attenuation coefficient of the samples and its dependence on photon energy and samples densities. An evaluation of the effects of this model on the Lowest Limit of Detection (LLD) is presented for geological samples placed in cylindrical containers that completely cover the top of an HPGe detector that has a 66% relative efficiency. The results are presented for energies in the range of 63 to 2614keV, for sample densities varying from 1.5 to 2.5 g{center_dot}cm{sup -3}, and for the height of the material on the detector of 2 cm and 5 cm. For a sample density of 2.0 g{center_dot}cm{sup -3} and with a 2cm height, the method allowed for a lowering of 3.4% of the LLD for the energy of 1460keV, from {sup 40}K, 3.9% for the energy of 911keV from {sup 228}Ac, 4.5% for the energy of 609keV from {sup 214}Bi, and8.3% for the energy of 92keV from {sup 234}Th. For a sample density of 1.75 g{center_dot}cm{sup -3} and a 5cm height, the method indicates a lowering of 6.5%, 7.4%, 8.3% and 12.9% of the LLD for the same respective energies.

  2. Scalar products in models with the GL(3) trigonometric R-matrix: General case

    NASA Astrophysics Data System (ADS)

    Pakuliak, S. Z.; Ragoucy, E.; Slavnov, N. A.

    2014-07-01

    We study quantum integrable models with the GL( 3) trigonometric R-matrix solvable by the nested algebraic Bethe ansatz and obtain an explicit representation for a scalar product of generic Bethe vectors in terms of a sum over partitions of Bethe parameters. This representation generalizes the known formula for scalar products in models with the GL( 3)-invariant R-matrix.

  3. Fuzzy Field Theory as a Random Matrix Model

    NASA Astrophysics Data System (ADS)

    Tekel, Juraj

    This dissertation considers the theory of scalar fields on fuzzy spaces from the point of view of random matrices. First we define random matrix ensembles, which are natural description of such theory. These ensembles are new and the novel feature is a presence of kinetic term in the probability measure, which couples the random matrix to a set of external matrices and thus breaks the original symmetry. Considering the case of a free field ensemble, which is generalization of a Gaussian matrix ensemble, we develop a technique to compute expectation values of the observables of the theory based on explicit Wick contractions and we write down recursion rules for these. We show that the eigenvalue distribution of the random matrix follows the Wigner semicircle distribution with a rescaled radius. We also compute distributions of the matrix Laplacian of the random matrix given by the new term and demonstrate that the eigenvalues of these two matrices are correlated. We demonstrate the robustness of the method by computing expectation values and distributions for more complicated observables. We then consider the ensemble corresponding to an interacting field theory, with a quartic interaction. We use the same method to compute the distribution of the eigenvalues and show that the presence of the kinetic terms rescales the distribution given by the original theory, which is a polynomially deformed Wigner semicircle. We compute the eigenvalue distribution of the matrix Laplacian and the joint distribution up to second order in the correlation and we show that the correlation between the two changes from the free field case. Finally, as an application of these results, we compute the phase diagram of the fuzzy scalar field theory, we find multiscaling which stabilizes this diagram in the limit of large matrices and compare it with the results obtained numerically and by considering the kinetic part as a perturbation.

  4. Application of fiber bridging models to fatigue crack growth in unidirectional titanium matrix composites

    NASA Technical Reports Server (NTRS)

    Bakuckas, J. G., Jr.; Johnson, W. S.

    1992-01-01

    Several fiber bridging models were reviewed and applied to study the matrix fatigue crack growth behavior in center notched (0)(sub 8) SCS-6/Ti-15-3 and (0)(sub 4) SCS-6/Ti-6Al-4V laminates. Observations revealed that fatigue damage consisted primarily of matrix cracks and fiber matrix interfacial failure in the (0)(sub 8) SCS-6/Ti-15-3 laminates. Fiber-matrix interface failure included fracture of the brittle reaction zone and cracking between the two carbon rich fiber coatings. Intact fibers in the wake of the matrix cracks reduce the stress intensity factor range. Thus, an applied stress intensity factor range is inappropriate to characterize matrix crack growth behavior. Fiber bridging models were used to determine the matrix stress intensity factor range in titanium metal matrix composites. In these models, the fibers in the wake of the crack are idealized as a closure pressure. An unknown constant frictional shear stress is assumed to act along the debond or slip length of the bridging fibers. The frictional shear stress was used as a curve fitting parameter to available data (crack growth data, crack opening displacement data, and debond length data). Large variations in the frictional shear stress required to fit the experimental data indicate that the fiber bridging models in their present form lack predictive capabilities. However, these models provide an efficient and relatively simple engineering method for conducting parametric studies of the matrix growth behavior based on constituent properties.

  5. Neutron diffraction measurements and modeling of residual strains in metal matrix composites

    NASA Technical Reports Server (NTRS)

    Saigal, A.; Leisk, G. G.; Hubbard, C. R.; Misture, S. T.; Wang, X. L.

    1996-01-01

    Neutron diffraction measurements at room temperature are used to characterize the residual strains in tungsten fiber-reinforced copper matrix, tungsten fiber-reinforced Kanthal matrix, and diamond particulate-reinforced copper matrix composites. Results of finite element modeling are compared with the neutron diffraction data. In tungsten/Kanthal composites, the fibers are in compression, the matrix is in tension, and the thermal residual strains are a strong function of the volume fraction of fibers. In copper matrix composites, the matrix is in tension and the stresses are independent of the volume fraction of tungsten fibers or diamond particles and the assumed stress free temperature because of the low yield strength of the matrix phase.

  6. Modeling the Mechanical Behavior of Ceramic Matrix Composite Materials

    NASA Technical Reports Server (NTRS)

    Jordan, William

    1998-01-01

    Ceramic matrix composites are ceramic materials, such as SiC, that have been reinforced by high strength fibers, such as carbon. Designers are interested in using ceramic matrix composites because they have the capability of withstanding significant loads while at relatively high temperatures (in excess of 1,000 C). Ceramic matrix composites retain the ceramic materials ability to withstand high temperatures, but also possess a much greater ductility and toughness. Their high strength and medium toughness is what makes them of so much interest to the aerospace community. This work concentrated on two different tasks. The first task was to do an extensive literature search into the mechanical behavior of ceramic matrix composite materials. This report contains the results of this task. The second task was to use this understanding to help interpret the ceramic matrix composite mechanical test results that had already been obtained by NASA. Since the specific details of these test results are subject to the International Traffic in Arms Regulations (ITAR), they are reported in a separate document (Jordan, 1997).

  7. CONSTRUCTING, PERTURBATION ANALYSIIS AND TESTING OF A MULTI-HABITAT PERIODIC MATRIX POPULATION MODEL

    EPA Science Inventory

    We present a matrix model that explicitly incorporates spatial habitat structure and seasonality and discuss preliminary results from a landscape level experimental test. Ecological risk to populations is often modeled without explicit treatment of spatially or temporally distri...

  8. Localization in band random matrix models with and without increasing diagonal elements.

    PubMed

    Wang, Wen-ge

    2002-06-01

    It is shown that localization of eigenfunctions in the Wigner band random matrix model with increasing diagonal elements can be related to localization in a band random matrix model with random diagonal elements. The relation is obtained by making use of a result of a generalization of Brillouin-Wigner perturbation theory, which shows that reduced Hamiltonian matrices with relatively small dimensions can be introduced for nonperturbative parts of eigenfunctions, and by employing intermediate basis states, which can improve the method of the reduced Hamiltonian matrix. The latter model deviates from the standard band random matrix model mainly in two aspects: (i) the root mean square of diagonal elements is larger than that of off-diagonal elements within the band, and (ii) statistical distributions of the matrix elements are close to the Lévy distribution in their central parts, except in the high top regions.

  9. Semiclassical matrix model for quantum chaotic transport with time-reversal symmetry

    SciTech Connect

    Novaes, Marcel

    2015-10-15

    We show that the semiclassical approach to chaotic quantum transport in the presence of time-reversal symmetry can be described by a matrix model. In other words, we construct a matrix integral whose perturbative expansion satisfies the semiclassical diagrammatic rules for the calculation of transport statistics. One of the virtues of this approach is that it leads very naturally to the semiclassical derivation of universal predictions from random matrix theory.

  10. Unified continuum damage model for matrix cracking in composite rotor blades

    SciTech Connect

    Pollayi, Hemaraju; Harursampath, Dineshkumar

    2015-03-10

    This paper deals with modeling of the first damage mode, matrix micro-cracking, in helicopter rotor/wind turbine blades and how this effects the overall cross-sectional stiffness. The helicopter/wind turbine rotor system operates in a highly dynamic and unsteady environment leading to severe vibratory loads present in the system. Repeated exposure to this loading condition can induce damage in the composite rotor blades. These rotor/turbine blades are generally made of fiber-reinforced laminated composites and exhibit various competing modes of damage such as matrix micro-cracking, delamination, and fiber breakage. There is a need to study the behavior of the composite rotor system under various key damage modes in composite materials for developing Structural Health Monitoring (SHM) system. Each blade is modeled as a beam based on geometrically non-linear 3-D elasticity theory. Each blade thus splits into 2-D analyzes of cross-sections and non-linear 1-D analyzes along the beam reference curves. Two different tools are used here for complete 3-D analysis: VABS for 2-D cross-sectional analysis and GEBT for 1-D beam analysis. The physically-based failure models for matrix in compression and tension loading are used in the present work. Matrix cracking is detected using two failure criterion: Matrix Failure in Compression and Matrix Failure in Tension which are based on the recovered field. A strain variable is set which drives the damage variable for matrix cracking and this damage variable is used to estimate the reduced cross-sectional stiffness. The matrix micro-cracking is performed in two different approaches: (i) Element-wise, and (ii) Node-wise. The procedure presented in this paper is implemented in VABS as matrix micro-cracking modeling module. Three examples are presented to investigate the matrix failure model which illustrate the effect of matrix cracking on cross-sectional stiffness by varying the applied cyclic load.

  11. Improved Porosity and Permeability Models with Coal Matrix Block Deformation Effect

    NASA Astrophysics Data System (ADS)

    Zhou, Yinbo; Li, Zenghua; Yang, Yongliang; Zhang, Lanjun; Qi, Qiangqiang; Si, Leilei; Li, Jinhu

    2016-09-01

    Coal permeability is an important parameter in coalbed methane (CBM) exploration and greenhouse gas storage. A reasonable theoretical permeability model is helpful for analysing the influential factors of gas flowing in a coalbed. As an unconventional reservoir, the unique feature of a coal structure deformation determines the state of gas seepage. The matrix block and fracture change at the same time due to changes in the effective stress and adsorption; the porosity and permeability also change. Thus, the matrix block deformation must be ignored in the theoretical model. Based on the cubic model, we analysed the characteristics of matrix block deformation and fracture deformation. The new models were developed with the change in matrix block width a. We compared the new models with other models, such as the Palmer-Manson (P-M) model and the Shi-Durucan (S-D) model, and used a constant confining stress. By matching the experimental data, our model matches quite well and accurately predicts the evolution of permeability. The sorption-induced strain coefficient f differs between the strongly adsorbing gases and weakly adsorbing gases because the matrix block deformation is more sensitive for the weakly adsorbing gases and the coefficient f is larger. The cubic relationship between porosity and permeability overlooks the importance of the matrix block deformation. In our model, the matrix block deformation suppresses the permeability ratio growth. With a constant confining stress, the weight of the matrix block deformation for the strongly adsorbing gases is larger than that for weakly adsorbing gases. The weight values increase as the pore pressure increases. It can be concluded that the matrix block deformation is an important phenomenon for researching coal permeability and can be crucial for the prediction of CBM production due to the change in permeability.

  12. High Strain Rate Deformation Modeling of a Polymer Matrix Composite. Part 2; Composite Micromechanical Model

    NASA Technical Reports Server (NTRS)

    Goldberg, Robert K.; Stouffer, Donald C.

    1998-01-01

    Recently applications have exposed polymer matrix composite materials to very high strain rate loading conditions, requiring an ability to understand and predict the material behavior under these extreme conditions. In this second paper of a two part report, a three-dimensional composite micromechanical model is described which allows for the analysis of the rate dependent, nonlinear deformation response of a polymer matrix composite. Strain rate dependent inelastic constitutive equations utilized to model the deformation response of a polymer are implemented within the micromechanics method. The deformation response of two representative laminated carbon fiber reinforced composite materials with varying fiber orientation has been predicted using the described technique. The predicted results compare favorably to both experimental values and the response predicted by the Generalized Method of Cells, a well-established micromechanics analysis method.

  13. Preconditioning of Nonlinear Mixed Effects Models for Stabilisation of Variance-Covariance Matrix Computations.

    PubMed

    Aoki, Yasunori; Nordgren, Rikard; Hooker, Andrew C

    2016-03-01

    As the importance of pharmacometric analysis increases, more and more complex mathematical models are introduced and computational error resulting from computational instability starts to become a bottleneck in the analysis. We propose a preconditioning method for non-linear mixed effects models used in pharmacometric analyses to stabilise the computation of the variance-covariance matrix. Roughly speaking, the method reparameterises the model with a linear combination of the original model parameters so that the Hessian matrix of the likelihood of the reparameterised model becomes close to an identity matrix. This approach will reduce the influence of computational error, for example rounding error, to the final computational result. We present numerical experiments demonstrating that the stabilisation of the computation using the proposed method can recover failed variance-covariance matrix computations, and reveal non-identifiability of the model parameters.

  14. Form factors in quantum integrable models with GL(3)-invariant R-matrix

    NASA Astrophysics Data System (ADS)

    Pakuliak, S.; Ragoucy, E.; Slavnov, N. A.

    2014-04-01

    We study integrable models solvable by the nested algebraic Bethe ansatz and possessing GL(3)-invariant R-matrix. We obtain determinant representations for form factors of off-diagonal entries of the monodromy matrix. These representations can be used for the calculation of form factors and correlation functions of the XXX SU(3)-invariant Heisenberg chain.

  15. Recognizing Uncertainty in the Q-Matrix via a Bayesian Extension of the DINA Model

    ERIC Educational Resources Information Center

    DeCarlo, Lawrence T.

    2012-01-01

    In the typical application of a cognitive diagnosis model, the Q-matrix, which reflects the theory with respect to the skills indicated by the items, is assumed to be known. However, the Q-matrix is usually determined by expert judgment, and so there can be uncertainty about some of its elements. Here it is shown that this uncertainty can be…

  16. Model-based OPC using the MEEF matrix II

    NASA Astrophysics Data System (ADS)

    Lei, Junjiang; Hong, Le; Lippincott, George; Word, James

    2014-03-01

    In the traditional OPC (Optical Proximity Correction) procedure, edges in a layout are broken into fragments and each fragment is iteratively adjusted by multiplying its EPE (Edge Placement Error) with a carefully selected or calculated feedback. However, the ever-shrinking technology nodes in recent years bring stronger fragment to fragment interaction. The feedback tuning approach driven by a single fragment EPE is no longer sufficient to achieve good pattern fidelity with reasonable turn-around-time. Various novel techniques such as matrix OPC [1, 2] have been developed in the past to incorporate the influence of neighboring fragments into each fragment's movement. Here we introduce a neighboraware feedback controller for full chip level OPC applications, following the concept and algorithms of the matrix OPC that were laid out in Cobb and Granik's work [1]. We present experimental results and discuss the benefits and challenges of the proposed feedback controller.

  17. Neutrinoless double beta nuclear matrix elements around mass 80 in the nuclear shell-model

    NASA Astrophysics Data System (ADS)

    Yoshinaga, N.; Higashiyama, K.; Taguchi, D.; Teruya, E.

    2015-05-01

    The observation of the neutrinoless double-beta decay can determine whether the neutrino is a Majorana particle or not. For theoretical nuclear physics it is particularly important to estimate three types of matrix elements, namely Fermi (F), Gamow-Teller (GT), and tensor (T) matrix elements. In this paper, we carry out shell-model calculations and also pair-truncated shell-model calculations to check the model dependence in the case of mass A=82 nuclei.

  18. General structure of democratic mass matrix of quark sector in E6 model

    NASA Astrophysics Data System (ADS)

    Ciftci, R.; ćiftci, A. K.

    2016-03-01

    An extension of the Standard Model (SM) fermion sector, which is inspired by the E6 Grand Unified Theory (GUT) model, might be a good candidate to explain a number of unanswered questions in SM. Existence of the isosinglet quarks might explain great mass difference of bottom and top quarks. Also, democracy on mass matrix elements is a natural approach in SM. In this study, we have given general structure of Democratic Mass Matrix (DMM) of quark sector in E6 model.

  19. From matrix models' topological expansion to topological string theories: counting surfaces with algebraic geometry

    NASA Astrophysics Data System (ADS)

    Orantin, N.

    2007-09-01

    The 2-matrix model has been introduced to study Ising model on random surfaces. Since then, the link between matrix models and combinatorics of discrete surfaces has strongly tightened. This manuscript aims to investigate these deep links and extend them beyond the matrix models, following my work's evolution. First, I take care to define properly the hermitian 2 matrix model which gives rise to generating functions of discrete surfaces equipped with a spin structure. Then, I show how to compute all the terms in the topological expansion of any observable by using algebraic geometry tools. They are obtained as differential forms on an algebraic curve associated to the model: the spectral curve. In a second part, I show how to define such differentials on any algebraic curve even if it does not come from a matrix model. I then study their numerous symmetry properties under deformations of the algebraic curve. In particular, I show that these objects coincide with the topological expansion of the observable of a matrix model if the algebraic curve is the spectral curve of this model. Finally, I show that fine tuning the parameters ensure that these objects can be promoted to modular invariants and satisfy the holomorphic anomaly equation of the Kodaira-Spencer theory. This gives a new hint that the Dijkgraaf-Vafa conjecture is correct.

  20. Analytical Micromechanics Modeling Technique Developed for Ceramic Matrix Composites Analysis

    NASA Technical Reports Server (NTRS)

    Min, James B.

    2005-01-01

    Ceramic matrix composites (CMCs) promise many advantages for next-generation aerospace propulsion systems. Specifically, carbon-reinforced silicon carbide (C/SiC) CMCs enable higher operational temperatures and provide potential component weight savings by virtue of their high specific strength. These attributes may provide systemwide benefits. Higher operating temperatures lessen or eliminate the need for cooling, thereby reducing both fuel consumption and the complex hardware and plumbing required for heat management. This, in turn, lowers system weight, size, and complexity, while improving efficiency, reliability, and service life, resulting in overall lower operating costs.

  1. Nuclear Matrix Model: A path to nuclear physics from superstrings

    SciTech Connect

    Hashimoto, Koji

    2011-10-21

    We derive nuclear forces and nuclear density saturation from large N{sub c} QCD, by applying AdS/CFT correspondence of string theory, called holographic QCD. This is made possible by a new description of a multi-baryon system in the holographic QCD. The description employs a matrix quantum mechanics which can be derived via the correspondence. This talk is based on collaboration work with N. Iizuka and P. Yi [1], with N. Iizuka [2, 3] and with T. Morita [4].

  2. A review of failure models for unidirectional ceramic matrix composites under monotonic loads

    NASA Technical Reports Server (NTRS)

    Tripp, David E.; Hemann, John H.; Gyekenyesi, John P.

    1989-01-01

    Ceramic matrix composites offer significant potential for improving the performance of turbine engines. In order to achieve their potential, however, improvements in design methodology are needed. In the past most components using structural ceramic matrix composites were designed by trial and error since the emphasis of feasibility demonstration minimized the development of mathematical models. To understand the key parameters controlling response and the mechanics of failure, the development of structural failure models is required. A review of short term failure models with potential for ceramic matrix composite laminates under monotonic loads is presented. Phenomenological, semi-empirical, shear-lag, fracture mechanics, damage mechanics, and statistical models for the fast fracture analysis of continuous fiber unidirectional ceramic matrix composites under monotonic loads are surveyed.

  3. Numerical modelling of transdermal delivery from matrix systems: parametric study and experimental validation with silicone matrices.

    PubMed

    Snorradóttir, Bergthóra S; Jónsdóttir, Fjóla; Sigurdsson, Sven Th; Másson, Már

    2014-08-01

    A model is presented for transdermal drug delivery from single-layered silicone matrix systems. The work is based on our previous results that, in particular, extend the well-known Higuchi model. Recently, we have introduced a numerical transient model describing matrix systems where the drug dissolution can be non-instantaneous. Furthermore, our model can describe complex interactions within a multi-layered matrix and the matrix to skin boundary. The power of the modelling approach presented here is further illustrated by allowing the possibility of a donor solution. The model is validated by a comparison with experimental data, as well as validating the parameter values against each other, using various configurations with donor solution, silicone matrix and skin. Our results show that the model is a good approximation to real multi-layered delivery systems. The model offers the ability of comparing drug release for ibuprofen and diclofenac, which cannot be analysed by the Higuchi model because the dissolution in the latter case turns out to be limited. The experiments and numerical model outlined in this study could also be adjusted to more general formulations, which enhances the utility of the numerical model as a design tool for the development of drug-loaded matrices for trans-membrane and transdermal delivery.

  4. Incorporating PROPACK into PEST to Estimate the Model Resolution Matrix for Large Groundwater Flow Models

    NASA Astrophysics Data System (ADS)

    Muffels, C.; Zhang, H.; Doherty, J.; Tonkin, M.; Hunt, R.; Anderson, M.

    2006-12-01

    Regularized inversion of groundwater flow models can be used to delineate geological heterogeneities using subspace methods like the singular value decomposition (SVD). To characterize heterogeneity, thousands of system parameters and, with appropriate regularization, thousands of observations may be necessary. The SVD method is not practical because it requires significant memory space and is time consuming. In previous work, we demonstrated the LSQR can be used to estimate the many unknown parameters in large groundwater flow inverse problems. However, in doing so, a resolution analysis is needed to characterize the reliability of the resulting model parameters. We adopted an approach developed for large seismic tomography problems and incorporate the PROPACK package into PEST, a model independent parameter estimation program. PROPACK estimates singular values and vectors for large sparse matrices efficiently and accurately based on the Lanczos bidiagonalization, the core of LSQR, with partial reorthogonalization. Unlike other LSQR-based resolution approaches, this PROPACK-based approach calculates the full resolution matrix. We estimate the model resolution matrix for a synthetic approximation based on a regional MODFLOW model of the Trout Lake Basin, Wisconsin, and compare it with results from the more commonly used SVD approach.

  5. Product spectrum matrix feature extraction and recognition of radar deception jamming

    NASA Astrophysics Data System (ADS)

    Tian, Xiao; Tang, Bin; Gui, Guan

    2013-12-01

    A deception jamming recognition algorithm is proposed based on product spectrum matrix (SPM). Firstly, the product spectral in the different pulse repetition interval (PRI) is calculated, and the product spectral of frequency-slow time is arranged into a two-dimensional matrix. Secondly, non-negative matrix factorisation (NMF) is used to extract the features, and further the separability of the characteristic parameters is analysed by the F-Ratio. Finally, the best features are selected to recognise the deception jamming. The experimental results show that the average recognition accuracy of the proposed deception jamming algorithm is higher than 90% when SNR is greater than 6dB.

  6. A Coupled Model of Neovessel Growth and Matrix Mechanics Describes and Predicts Angiogenesis In Vitro

    PubMed Central

    Edgar, Lowell T.; Maas, Steve A.; Guilkey, James E.; Weiss, Jeffrey A.

    2014-01-01

    During angiogenesis, sprouting microvessels interact with the extracellular matrix (ECM) by degrading and reorganizing the matrix, applying traction forces and producing deformation. Morphometric features of the resulting microvascular network are affected by the interaction between the matrix and angiogenic microvessels. The objective of this study was to develop a continuous-discrete modeling approach to simulate mechanical interactions between growing neovessels and the deformation of the matrix in vitro. This was accomplished by coupling an existing angiogenesis growth model which uses properties of the ECM to regulate angiogenic growth with the nonlinear finite element software FEBio (www.febio.org). FEBio solves for the deformation and remodeling of the matrix caused by active stress generated by neovessel sprouts, and this deformation was used to update the ECM into the current configuration. After mesh resolution and parameter sensitivity studies, the model was used to accurately predict vascular alignment for various gel boundary conditions. Alignment primarily arises passively as microvessels convect with the deformation of the matrix, but active alignment along collagen fibrils plays a role as well. Predictions of alignment were most sensitive to the range over which active stresses were applied and the viscoelastic time constant in the material model. The computational framework provides a flexible platform for interpreting in vitro investigations of vessel-matrix interactions, predicting new experiments, and simulating conditions that are outside current experimental capabilities. PMID:25429840

  7. Improved Scheme for Modeling Mass Transfer between Fracture and Matrix Continua with Particle Tracking Method

    SciTech Connect

    L. Pan; Y. Seol; G. Bodvarsson

    2004-04-29

    The dual-continuum random-walk particle tracking approach is an attractive simulation method for simulating transport in a fractured porous medium. In order to be truly successful for such a model, however, the key issue is to properly simulate the mass transfer between the fracture and matrix continua. In a recent paper, Pan and Bodvarsson (2002) proposed an improved scheme for simulating fracture-matrix mass transfer, by introducing the concept of activity range into the calculation of fracture-matrix particle-transfer probability. By comparing with analytical solutions, they showed that their scheme successfully captured the transient diffusion depth into the matrix without any additional subgrid (matrix) cells. This technical note presents an expansion of their scheme to cases in which significant water flow through the fracture-matrix interface exists. The dual-continuum particle tracker with this new scheme was found to be as accurate as a numerical model using a more detailed grid. The improved scheme can be readily incorporated into the existing particle-tracking code, while still maintaining the advantage of needing no additional matrix cells to capture transient features of particle penetration into the matrix.

  8. A Model for Estimating Nonlinear Deformation and Damage in Ceramic Matrix Composites (Preprint)

    DTIC Science & Technology

    2011-07-01

    AFRL-RX-WP-TP-2011-4232 A MODEL FOR ESTIMATING NONLINEAR DEFORMATION AND DAMAGE IN CERAMIC MATRIX COMPOSITES (PREPRINT) Unni Santhosh and...5a. CONTRACT NUMBER In-house 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 62102F 6. AUTHOR(S) Unni Santhosh and Jalees Ahmad 5d. PROJECT...Composite Materials, 2010 A Model for Estimating Nonlinear Deformation and Damage in Ceramic Matrix Composites Unni Santhosh and Jalees Ahmad Research

  9. Time series, correlation matrices and random matrix models

    SciTech Connect

    Vinayak; Seligman, Thomas H.

    2014-01-08

    In this set of five lectures the authors have presented techniques to analyze open classical and quantum systems using correlation matrices. For diverse reasons we shall see that random matrices play an important role to describe a null hypothesis or a minimum information hypothesis for the description of a quantum system or subsystem. In the former case various forms of correlation matrices of time series associated with the classical observables of some system. The fact that such series are necessarily finite, inevitably introduces noise and this finite time influence lead to a random or stochastic component in these time series. By consequence random correlation matrices have a random component, and corresponding ensembles are used. In the latter we use random matrices to describe high temperature environment or uncontrolled perturbations, ensembles of differing chaotic systems etc. The common theme of the lectures is thus the importance of random matrix theory in a wide range of fields in and around physics.

  10. OC Chondrule, Rim and Matrix Compositions: A Model

    NASA Astrophysics Data System (ADS)

    Alexander, C. M. O'd.

    1996-03-01

    The peak temperatures chondrules experienced, based on their liquidus temperatures, range from 1500 K to 2000 K. At these temperatures and nebular pressures most elements are volatile, but generally the alkali metals and S have been the only major elements considered as such. However, correlated variations in Mg and Al abundances, if they are not due to precursor compositions, require the loss of up to 50% of the SiO2 from some chondrules. The more volatile FeO would have been lost to an even greater extent. Here it is shown that if the material lost from chondrules recondenses onto the fine grained material which survived the chondrule forming process, chondrule rim and matrix compositions can be explained.

  11. Detection of extracellular matrix modification in cancer models with inverse spectroscopic optical coherence tomography

    NASA Astrophysics Data System (ADS)

    Spicer, Graham L. C.; Azarin, Samira M.; Yi, Ji; Young, Scott T.; Ellis, Ronald; Bauer, Greta M.; Shea, Lonnie D.; Backman, Vadim

    2016-10-01

    In cancer biology, there has been a recent effort to understand tumor formation in the context of the tissue microenvironment. In particular, recent progress has explored the mechanisms behind how changes in the cell-extracellular matrix ensemble influence progression of the disease. The extensive use of in vitro tissue culture models in simulant matrix has proven effective at studying such interactions, but modalities for non-invasively quantifying aspects of these systems are scant. We present the novel application of an imaging technique, Inverse Spectroscopic Optical Coherence Tomography, for the non-destructive measurement of in vitro biological samples during matrix remodeling. Our findings indicate that the nanoscale-sensitive mass density correlation shape factor D of cancer cells increases in response to a more crosslinked matrix. We present a facile technique for the non-invasive, quantitative study of the micro- and nano-scale structure of the extracellular matrix and its host cells.

  12. Modeling the Effect of Multiple Matrix Cracking Modes on Cyclic Hysteresis Loops of 2D Woven Ceramic-Matrix Composites

    NASA Astrophysics Data System (ADS)

    Longbiao, Li

    2016-08-01

    In this paper, the effect of multiple matrix cracking modes on cyclic loading/unloading hysteresis loops of 2D woven ceramic-matrix composites (CMCs) has been investigated. The interface slip between fibers and the matrix existed in matrix cracking mode 3 and mode 5, in which matrix cracking and interface debonding occurred in longitudinal yarns, are considered as the major reason for hysteresis loops of 2D woven CMCs. The effects of fiber volume content, peak stress, matrix crack spacing, interface properties, matrix cracking mode proportion and interface wear on interface slip and hysteresis loops have been analyzed. The cyclic loading/unloading hysteresis loops of 2D woven SiC/SiC composite corresponding to different peak stresses have been predicted using the present analysis. It was found that the damage parameter, i.e., the proportion of matrix cracking mode 3 in the entire cracking modes of the composite, increases with increasing peak stress.

  13. Estimation and Q-Matrix Validation for Diagnostic Classification Models

    ERIC Educational Resources Information Center

    Feng, Yuling

    2013-01-01

    Diagnostic classification models (DCMs) are structured latent class models widely discussed in the field of psychometrics. They model subjects' underlying attribute patterns and classify subjects into unobservable groups based on their mastery of attributes required to answer the items correctly. The effective implementation of DCMs depends…

  14. A LISREL Model for the Analysis of Repeated Measures with a Patterned Covariance Matrix.

    ERIC Educational Resources Information Center

    Rovine, Michael J.; Molenaar, Peter C. M.

    1998-01-01

    Presents a LISREL model for the estimation of the repeated measures analysis of variance (ANOVA) with a patterned covariance matrix. The model is demonstrated for a 5 x 2 (Time x Group) ANOVA in which the data are assumed to be serially correlated. Similarities with the Statistical Analysis System PROC MIXED model are discussed. (SLD)

  15. A Physically Based Approach for Modeling Multiphase Fracture-Matrix Interaction in Fractured Porous Media

    SciTech Connect

    Wu, Yu-Shu; Pan, Lehua; Pruess, Karsten

    2004-03-15

    Modeling fracture-matrix interaction within a complex multiple phase flow system is a key issue for fractured reservoir simulation. Commonly used mathematical models for dealing with such interactions employ a dual- or multiple-continuum concept, in which fractures and matrix are represented as overlapping, different, but interconnected continua, described by parallel sets of conservation equations. The conventional single-point upstream weighting scheme, in which the fracture relative permeability is used to represent the counterpart at the fracture-matrix interface, is the most common scheme by which to estimate flow mobility for fracture-matrix flow terms. However, such a scheme has a serious flaw, which may lead to unphysical solutions or significant numerical errors. To overcome the limitation of the conventional upstream weighting scheme, this paper presents a physically based modeling approach for estimating physically correct relative permeability in calculating multiphase flow between fractures and the matrix, using continuity of capillary pressure at the fracture-matrix interface. The proposed approach has been implemented into two multiphase reservoir simulators and verified using analytical solutions and laboratory experimental data. The new method is demonstrated to be accurate, numerically efficient, and easy to implement in dual- or multiple-continuum models.

  16. Aroma behaviour during steam cooking within a potato starch-based model matrix.

    PubMed

    Descours, Emilie; Hambleton, Alicia; Kurek, Mia; Debeaufort, Fréderic; Voilley, Andrée; Seuvre, Anne-Marie

    2013-06-05

    To help understand the organoleptic qualities of steam cooked foods, the kinetics of aroma release during cooking in a potato starch based model matrix was studied. Behaviour of components having a major impact in potato flavour were studied using solid phase micro extraction-gas chromatography (SPME-GC). Evolution of microstructure of potato starch model-matrix during steam cooking process was analyzed using environmental scanning electron microscopy (ESEM). Both aroma compounds that are naturally present in starch matrix and those that were added were analyzed. Both the aroma compounds naturally presented and those added had different behaviour depending on their physico-chemical properties (hydrophobicity, saturation vapour pressure, molecular weight, etc.). The physical state of potato starch influences of the retention of aromatized matrix with Starch gelatinization appearing to be the major phenomenon influencing aroma release.

  17. The Use of Scattering Matrix to Model Multi-Modal Array Inspection with the Tfm

    NASA Astrophysics Data System (ADS)

    Zhang, J.; Drinkwater, B. W.; Wilcox, P. D.

    2009-03-01

    The scattering coefficient matrix describes the far field amplitude of scattered signals from a scatterer as a function of incident and scattering angles. In this paper an FE model is used to predict scattering matrices. By combining the predicted scattering coefficient matrix with a ray tracing model to predict the full matrix of array data, an efficient forward model of the complete array inspection process is presented. Longitudinal wave, shear waves and wave mode conversions are considered in the model. The TFM images for various wave mode combination cases from a weld sample are predicted and measured. Results show that by selecting the optimum array mode combination a good image for a given defect in the weld sample can be produced using an array. It is also shown how the model can be used to optimize the array inspection configuration.

  18. Models for predicting damage evolution in metal matrix composites subjected to cyclic loading

    SciTech Connect

    Allen, D.H.; Hurtado, L.D.; Helms, K.L.E.

    1995-03-01

    A thermomechanical analysis of a continuous fiber metal matrix composite (MMC) subjected to cyclic loading is performed herein. The analysis includes the effects of processing induced residual thermal stresses, matrix inelasticity, and interface cracking. Due to these complexities, the analysis is performed computationally using the finite element method. Matrix inelasticity is modelled with a rate dependent viscoplasticity model. Interface fracture is modelled by the use of a nonlinear interface constitutive model. The problem formulation is summarized, and results are given for a four-ply unidirectional SCS-6/{beta}21S titanium composite under high temperature isothermal mechanical fatigue. Results indicate rate dependent viscoplasticity can be a significant mechanism for dissipating the energy available for damage propagation, thus contributing to improved ductility of the composite. Results also indicate that the model may be useful for inclusion in life prediction methodologies for MMC`s.

  19. Unitary-matrix models as exactly solvable string theories

    NASA Technical Reports Server (NTRS)

    Periwal, Vipul; Shevitz, Danny

    1990-01-01

    Exact differential equations are presently found for the scaling functions of models of unitary matrices which are solved in a double-scaling limit, using orthogonal polynomials on a circle. For the case of the simplest, k = 1 model, the Painleve II equation with constant 0 is obtained; possible nonperturbative phase transitions exist for these models. Equations are presented for k = 2 and 3, and discussed with a view to asymptotic behavior.

  20. A Knowledge Matrix Modeling of the Intelligence Cycle

    DTIC Science & Technology

    2005-03-01

    Process, by modeling intelligence as an opportunistic, multi-source, multi-entity system of systems . The value of intelligence fusion is compared...network model , agencies would still have their own databases, but those databases would be searchable across agency lines. In this system , levels of...effort is to accurately model the flow of intelligence information through a multi-INT system and provide an output measure of total 1-3

  1. Chiral matrix model for the phase transition in QCD

    NASA Astrophysics Data System (ADS)

    Pisarski, Robert D.; Skokov, Vladimir

    2016-12-01

    We discuss how to model chiral symmetry restoration with an effective theory of deconfinement. The model includes fluctuations in the quarks to one loop order, while the mesons of the sigma model are treated in mean field approximation. We note that a new counterterm is required at T = 0, and a novel form of symmetry breaking at T ≠ 0. We discuss how to incorporate tetraquark states, representing JP =0+ scalar mesons, into a linear sigma model. We suggest that their effect upon the chiral phase transition is small.

  2. Bethe Vectors of Quantum Integrable Models with GL(3) Trigonometric R-Matrix

    NASA Astrophysics Data System (ADS)

    Belliard, Samuel; Pakuliak, Stanislav; Ragoucy, Eric; Slavnov, Nikita A.

    2013-10-01

    We study quantum integrable models with GL(3) trigonometric R-matrix and solvable by the nested algebraic Bethe ansatz. Using the presentation of the universal Bethe vectors in terms of projections of products of the currents of the quantum affine algebra U_q(widehat{{gl}}_3) onto intersections of different types of Borel subalgebras, we prove that the set of the nested Bethe vectors is closed under the action of the elements of the monodromy matrix.

  3. Sloppy-model universality class and the Vandermonde matrix.

    PubMed

    Waterfall, Joshua J; Casey, Fergal P; Gutenkunst, Ryan N; Brown, Kevin S; Myers, Christopher R; Brouwer, Piet W; Elser, Veit; Sethna, James P

    2006-10-13

    In a variety of contexts, physicists study complex, nonlinear models with many unknown or tunable parameters to explain experimental data. We explain why such systems so often are sloppy: the system behavior depends only on a few "stiff" combinations of the parameters and is unchanged as other "sloppy" parameter combinations vary by orders of magnitude. We observe that the eigenvalue spectra for the sensitivity of sloppy models have a striking, characteristic form with a density of logarithms of eigenvalues which is roughly constant over a large range. We suggest that the common features of sloppy models indicate that they may belong to a common universality class. In particular, we motivate focusing on a Vandermonde ensemble of multiparameter nonlinear models and show in one limit that they exhibit the universal features of sloppy models.

  4. Camera-Model Identification Using Markovian Transition Probability Matrix

    NASA Astrophysics Data System (ADS)

    Xu, Guanshuo; Gao, Shang; Shi, Yun Qing; Hu, Ruimin; Su, Wei

    Detecting the (brands and) models of digital cameras from given digital images has become a popular research topic in the field of digital forensics. As most of images are JPEG compressed before they are output from cameras, we propose to use an effective image statistical model to characterize the difference JPEG 2-D arrays of Y and Cb components from the JPEG images taken by various camera models. Specifically, the transition probability matrices derived from four different directional Markov processes applied to the image difference JPEG 2-D arrays are used to identify statistical difference caused by image formation pipelines inside different camera models. All elements of the transition probability matrices, after a thresholding technique, are directly used as features for classification purpose. Multi-class support vector machines (SVM) are used as the classification tool. The effectiveness of our proposed statistical model is demonstrated by large-scale experimental results.

  5. Modeling the Tensile Strength of Carbon Fiber - Reinforced Ceramic - Matrix Composites Under Multiple Fatigue Loading

    NASA Astrophysics Data System (ADS)

    Li, Longbiao

    2016-06-01

    An analytical method has been developed to investigate the effect of interface wear on the tensile strength of carbon fiber - reinforced ceramic - matrix composites (CMCs) under multiple fatigue loading. The Budiansky - Hutchinson - Evans shear - lag model was used to describe the micro stress field of the damaged composite considering fibers failure and the difference existed in the new and original interface debonded region. The statistical matrix multicracking model and fracture mechanics interface debonding criterion were used to determine the matrix crack spacing and interface debonded length. The interface shear stress degradation model and fibers strength degradation model have been adopted to analyze the interface wear effect on the tensile strength of the composite subjected to multiple fatigue loading. Under tensile loading, the fibers failure probabilities were determined by combining the interface wear model and fibers failure model based on the assumption that the fiber strength is subjected to two - parameter Weibull distribution and the loads carried by broken and intact fibers satisfy the Global Load Sharing criterion. The composite can no longer support the applied load when the total loads supported by broken and intact fibers approach its maximum value. The conditions of a single matrix crack and matrix multicrackings for tensile strength corresponding to multiple fatigue peak stress levels and different cycle number have been analyzed.

  6. A numerical dual-porosity model with semianalytical treatment of fracture/matrix flow

    NASA Astrophysics Data System (ADS)

    Zimmerman, Robert W.; Chen, Gang; Hadgu, Teklu; Bodvarsson, Gudmundur S.

    1993-07-01

    A new dual-porosity model is developed for single-phase fluid flow in fractured/porous media. Flow is assumed to take place through the fracture network and between the fractures and matrix blocks. The matrix blocks are treated in a lumped parameter manner, with a single average pressure used for each matrix block. Rather than assuming that fracture/matrix flux is proportional to the difference between the fracture pressure and matrix pressure at each point, as is done in the Warren-Root model, we use a nonlinear equation which more accurately models the flux over all time regimes, including both early and late times. This flux equation is compared with analytical solutions for spherical blocks with prescribed pressure variations on their boundaries. The nonlinear flux equation is also used as a source/sink term in the numerical simulator TOUGH. The modified code allows more accurate simulations than the conventional Warren-Root method, with a large savings (about 90%) in computational time compared to methods which explicitly discretize the matrix blocks.

  7. Modeling the Tensile Behavior of Cross-Ply C/SiC Ceramic-Matrix Composites

    NASA Astrophysics Data System (ADS)

    Li, L. B.; Song, Y. D.; Sun, Y. C.

    2015-07-01

    The tensile behavior of cross-ply C/SiC ceramic-matrix composites (CMCs) at room temperature has been investigated. Under tensile loading, the damage evolution process was observed with an optical microscope. A micromechanical approach was developed to predict the tensile stress-strain curve, which considers the damage mechanisms of transverse multicracking, matrix multicracking, fiber/matrix interface debonding, and fiber fracture. The shear-lag model was used to describe the microstress field of the damaged composite. By combining the shear-lag model with different damage models, the tensile stress-strain curve of cross-ply CMCs corresponding to each damage stage was modeled. The predicted tensile stress-strain curves of cross-ply C/SiC composites agreed with experimental data.

  8. a Matrix Model Representation of the Integrable Xxz Heisenberg Chain on Random Surfaces

    NASA Astrophysics Data System (ADS)

    Ambjørn, J.; Sedrakyan, A.

    2013-11-01

    We consider integrable models, i.e. models defined by R-matrices, on random Manhattan lattices (RML). The set of random Manhattan lattices is defined as the set dual to the lattice random surfaces embedded on a regular d-dimensional lattice. As an example we formulate a random matrix model where the partition function reproduces annealed average of the XXZ Heisenberg chain over all RML. A technique is presented which reduces the random matrix integration in partition function to an integration over their eigenvalues.

  9. A penny-shaped crack in a filament reinforced matrix. 1: The filament model

    NASA Technical Reports Server (NTRS)

    Erdogan, F.; Pacella, A. H.

    1973-01-01

    The electrostatic problem of a penny-shaped crack in an elastic matrix which reinforced by filaments or fibers perpendicular to the plane of the crack was studied. The elastic filament model was developed for application to evaluation studies of the stress intensity factor along the periphery of the crack, the stresses in the filaments or fibers, and the interface shear between the matrix and the filaments or fibers. The requirements expected of the model are a sufficiently accurate representation of the filament and applicability to the interaction problems involving a cracked elastic continuum with multi-filament reinforcements. The technique for developing the model and numerical examples of it are shown.

  10. Scalar products in models with a GL(3) trigonometric R-matrix: Highest coefficient

    NASA Astrophysics Data System (ADS)

    Pakuliak, S. Z.; Ragoucy, E.; Slavnov, N. A.

    2014-03-01

    We study quantum integrable models with a GL (3) trigonometric R-matrix solvable by the nested algebraic Bethe ansatz. Scalar products of Bethe vectors in such models can be expressed in terms of bilinear combinations of the highest coefficients. We show that there exist two different highest coefficients in the models with a GL (3) trigonometric R-matrix. We obtain various representations for the highest coefficients in terms of sums over partitions. We also prove several important properties of the highest coefficients, which are necessary for evaluating the scalar products.

  11. Adapted Boolean network models for extracellular matrix formation

    PubMed Central

    Wollbold, Johannes; Huber, René; Pohlers, Dirk; Koczan, Dirk; Guthke, Reinhard; Kinne, Raimund W; Gausmann, Ulrike

    2009-01-01

    Background Due to the rapid data accumulation on pathogenesis and progression of chronic inflammation, there is an increasing demand for approaches to analyse the underlying regulatory networks. For example, rheumatoid arthritis (RA) is a chronic inflammatory disease, characterised by joint destruction and perpetuated by activated synovial fibroblasts (SFB). These abnormally express and/or secrete pro-inflammatory cytokines, collagens causing joint fibrosis, or tissue-degrading enzymes resulting in destruction of the extra-cellular matrix (ECM). We applied three methods to analyse ECM regulation: data discretisation to filter out noise and to reduce complexity, Boolean network construction to implement logic relationships, and formal concept analysis (FCA) for the formation of minimal, but complete rule sets from the data. Results First, we extracted literature information to develop an interaction network containing 18 genes representing ECM formation and destruction. Subsequently, we constructed an asynchronous Boolean network with biologically plausible time intervals for mRNA and protein production, secretion, and inactivation. Experimental gene expression data was obtained from SFB stimulated by TGFβ1 or by TNFα and discretised thereafter. The Boolean functions of the initial network were improved iteratively by the comparison of the simulation runs to the experimental data and by exploitation of expert knowledge. This resulted in adapted networks for both cytokine stimulation conditions. The simulations were further analysed by the attribute exploration algorithm of FCA, integrating the observed time series in a fine-tuned and automated manner. The resulting temporal rules yielded new contributions to controversially discussed aspects of fibroblast biology (e.g., considerable expression of TNF and MMP9 by fibroblasts stimulation) and corroborated previously known facts (e.g., co-expression of collagens and MMPs after TNFα stimulation), but also revealed

  12. Micromechanism Based Modeling of Structural Life in Metal Matrix Composites

    DTIC Science & Technology

    2007-11-02

    6. AUTHOR(S) David H. Allen and Dimitris C. Lagoudas 5 . FUNDING NUMBERS F49620-94-1-0341 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES...MONITORING AGENCY NAME(S) AND ADDRESS(ES) AFOSR/NA 110 Duncan Avenue, Rm B115 Boiling AFB, DC 20332- 8050 11. SUPPLEMENTARY NOTES 12a. DISTRIBUTION...behavior; 4) modeling the effects of oxidation on the crack growth resistance of metals; and 5 ) the modeling of oxidation fronts in metals. In summary

  13. Matrix Solution of Coupled Differential Equations and Looped Car Following Models

    ERIC Educational Resources Information Center

    McCartney, Mark

    2008-01-01

    A simple mathematical model for the behaviour of how vehicles follow each other along a looped stretch of road is described. The resulting coupled first order differential equations are solved using appropriate matrix techniques and the physical significance of the model is discussed. A number possible classroom exercises are suggested to help…

  14. Development of a Matrix of Teaching Models Based on Instructional and Nurturant Effects

    ERIC Educational Resources Information Center

    Miller, Ava S.; Anderson, Stoerm E.

    2007-01-01

    The selection of appropriate teaching models with which to bring about meaningful learning is an important and fundamental concern of the professional educator. This paper describes the development of a matrix of models and effects that was a three step process involving the compilation of a list of effects; the development of effect categories by…

  15. The spatiotemporal MEG covariance matrix modeled as a sum of Kronecker products.

    PubMed

    Bijma, Fetsje; de Munck, Jan C; Heethaar, Rob M

    2005-08-15

    The single Kronecker product (KP) model for the spatiotemporal covariance of MEG residuals is extended to a sum of Kronecker products. This sum of KP is estimated such that it approximates the spatiotemporal sample covariance best in matrix norm. Contrary to the single KP, this extension allows for describing multiple, independent phenomena in the ongoing background activity. Whereas the single KP model can be interpreted by assuming that background activity is generated by randomly distributed dipoles with certain spatial and temporal characteristics, the sum model can be physiologically interpreted by assuming a composite of such processes. Taking enough terms into account, the spatiotemporal sample covariance matrix can be described exactly by this extended model. In the estimation of the sum of KP model, it appears that the sum of the first 2 KP describes between 67% and 93%. Moreover, these first two terms describe two physiological processes in the background activity: focal, frequency-specific alpha activity, and more widespread non-frequency-specific activity. Furthermore, temporal nonstationarities due to trial-to-trial variations are not clearly visible in the first two terms, and, hence, play only a minor role in the sample covariance matrix in terms of matrix power. Considering the dipole localization, the single KP model appears to describe around 80% of the noise and seems therefore adequate. The emphasis of further improvement of localization accuracy should be on improving the source model rather than the covariance model.

  16. A Taxonomy of Latent Structure Assumptions for Probability Matrix Decomposition Models.

    ERIC Educational Resources Information Center

    Meulders, Michel; De Boeck, Paul; Van Mechelen, Iven

    2003-01-01

    Proposed a taxonomy of latent structure assumptions for probability matrix decomposition (PMD) that includes the original PMD model and a three-way extension of the multiple classification latent class model. Simulation study results show the usefulness of the taxonomy. (SLD)

  17. Continuing Education Leadership Matrix: A Model for Practitioners in Higher Education

    ERIC Educational Resources Information Center

    Moroney, Peter

    2007-01-01

    Continuing education (CE) units are a diverse blend of philosophical and pedagogical approaches, personal aptitudes, and professional knowledge and skills. The Continuing Education Leadership Matrix model is presented as a conceptual framework for understanding and managing CE practice. The model is useful to leaders and managers working within CE…

  18. SMARTIES: Spheroids Modelled Accurately with a Robust T-matrix Implementation for Electromagnetic Scattering

    NASA Astrophysics Data System (ADS)

    Somerville, W. R. C.; Auguié, B.; Le Ru, E. C.

    2016-03-01

    SMARTIES calculates the optical properties of oblate and prolate spheroidal particles, with comparable capabilities and ease-of-use as Mie theory for spheres. This suite of MATLAB codes provides a fully documented implementation of an improved T-matrix algorithm for the theoretical modelling of electromagnetic scattering by particles of spheroidal shape. Included are scripts that cover a range of scattering problems relevant to nanophotonics and plasmonics, including calculation of far-field scattering and absorption cross-sections for fixed incidence orientation, orientation-averaged cross-sections and scattering matrix, surface-field calculations as well as near-fields, wavelength-dependent near-field and far-field properties, and access to lower-level functions implementing the T-matrix calculations, including the T-matrix elements which may be calculated more accurately than with competing codes.

  19. Computational modeling of structure of metal matrix composite in centrifugal casting process

    SciTech Connect

    Zagorski, Roman

    2007-04-07

    The structure of alumina matrix composite reinforced with crystalline particles obtained during centrifugal casting process are studied. Several parameters of cast process like pouring temperature, temperature, rotating speed and size of casting mould which influent on structure of composite are examined. Segregation of crystalline particles depended on other factors such as: the gradient of density of the liquid matrix and reinforcement, thermal processes connected with solidifying of the cast, processes leading to changes in physical and structural properties of liquid composite are also investigated. All simulation are carried out by CFD program Fluent. Numerical simulations are performed using the FLUENT two-phase free surface (air and matrix) unsteady flow model (volume of fluid model - VOF) and discrete phase model (DPM)

  20. Extension of a noninteractive reliability model for ceramic matrix composites

    NASA Technical Reports Server (NTRS)

    Duffy, Stephen F.; Wetherhold, Robert C.; Jain, Lalit K.

    1990-01-01

    Developments in the processing of high temperature ceramic composites demand innovative and progressive design protocols that adequately predict the thermal and mechanical behavior of these materials. The focus here is the extension of a reliability model for orthotropic ceramic composites. The approach chosen to describe failures leads to a noninteractive formulation of reliability that is phenomenological. This particular criterion, which was constructed using tensorial invariant theory, allows six potential failure modes to emerge.

  1. Collective field theory of a singular supersymmetric matrix model

    SciTech Connect

    de Mello Koch, R.; Rodrigues, J.P.

    1995-05-15

    The supersymmetric collective field theory with the potential {ital v}{prime}({ital x})={omega}{ital x}{minus}{eta}/{ital x} is studied. Consistency with supersymmetry enforces a two band solution. A supersymmetric classical configuration is found, and interpreted in terms of the density of zeroes of certain Laguerre polynomials. The spectrum of the model is then studied and is seen to correspond to a massless scalar and a Majorana fermion. The {ital x} space eigenfunctions are constructed and expressed in terms of Chebyshev polynomials. Higher order interactions are also discussed.

  2. Matrix model maps and reconstruction of AdS supergravity interactions

    SciTech Connect

    Cremonini, Sera; Mello Koch, Robert de; Jevicki, Antal

    2008-05-15

    We consider the question of reconstructing (cubic) SUGRA interactions in AdS/CFT. The method we introduce is based on the matrix model maps (MMP) which were previously successfully employed at the linearized level. The strategy is to start with the map for 1/2 BPS configurations, which is exactly known (to all orders) in the Hamiltonian framework. We then use the extension of the matrix model map with the corresponding Ward identities to completely specify the interaction. A central point in this construction is the nonvanishing of off-shell interactions (even for highest-weight states)

  3. Meaning-making and the matrix model: does one size really fit all?

    PubMed

    Neimeyer, Robert A

    2005-09-01

    Despite the multifocal complexity of the matrix model (C.R. Snyder & T.R. Elliott, this issue, pp. 1033-1054), its close correspondence with the theoretical dialectics and philosophy of clinical constructivism auger well for its capacity to articulate with existing approaches to graduate education in psychology. In this article points of contact are documented between the two approaches, and a caveat is included about the limits of the matrix model in ensuring greater relevance of clinical training to the settings in which contemporary professionals will work.

  4. Modeling the matrix of articular cartilage using a continuous fiber angular distribution predicts many observed phenomena.

    PubMed

    Ateshian, Gerard A; Rajan, Vikram; Chahine, Nadeen O; Canal, Clare E; Hung, Clark T

    2009-06-01

    Cartilage is a hydrated soft tissue whose solid matrix consists of negatively charged proteoglycans enmeshed within a fibrillar collagen network. Though many aspects of cartilage mechanics are well understood today, most notably in the context of porous media mechanics, there remain a number of responses observed experimentally whose prediction from theory has been challenging. In this study the solid matrix of cartilage is modeled with a continuous fiber angular distribution, where fibers can only sustain tension, swelled by the osmotic pressure of a proteoglycan ground matrix. It is shown that this representation of cartilage can predict a number of observed phenomena in relation to the tissue's equilibrium response to mechanical and osmotic loading, when flow-dependent and flow-independent viscoelastic effects have subsided. In particular, this model can predict the transition of Poisson's ratio from very low values in compression (approximately 0.02) to very high values in tension (approximately 2.0). Most of these phenomena cannot be explained when using only three orthogonal fiber bundles to describe the tissue matrix, a common modeling assumption used to date. The main picture emerging from this analysis is that the anisotropy of the fibrillar matrix of articular cartilage is intimately dependent on the mechanism of tensed fiber recruitment, in the manner suggested by our recent theoretical study (Ateshian, 2007, ASME J. Biomech. Eng., 129(2), pp. 240-249).

  5. A phenomenological cohesive model for the macroscopic simulation of cell-matrix adhesions.

    PubMed

    Cóndor, M; García-Aznar, J M

    2017-02-17

    Cell adhesion is crucial for cells to not only physically interact with each other but also sense their microenvironment and respond accordingly. In fact, adherent cells can generate physical forces that are transmitted to the surrounding matrix, regulating the formation of cell-matrix adhesions. The main purpose of this work is to develop a computational model to simulate the dynamics of cell-matrix adhesions through a cohesive formulation within the framework of the finite element method and based on the principles of continuum damage mechanics. This model enables the simulation of the mechanical adhesion between cell and extracellular matrix (ECM) as regulated by local multidirectional forces and thus predicts the onset and growth of the adhesion. In addition, this numerical approach allows the simulation of the cell as a whole, as it models the complete mechanical interaction between cell and ECM. As a result, we can investigate and quantify how different mechanical conditions in the cell (e.g., contractile forces, actin cytoskeletal properties) or in the ECM (e.g., stiffness, external forces) can regulate the dynamics of cell-matrix adhesions.

  6. Modeling the Matrix of Articular Cartilage Using a Continuous Fiber Angular Distribution Predicts Many Observed Phenomena

    PubMed Central

    Ateshian, Gerard A.; Rajan, Vikram; Chahine, Nadeen O.; Canal, Clare E.; Hung, Clark T.

    2010-01-01

    Background Cartilage is a hydrated soft tissue whose solid matrix consists of negatively charged proteoglycans enmeshed within a fibrillar collagen network. Though many aspects of cartilage mechanics are well understood today, most notably in the context of porous media mechanics, there remain a number of responses observed experimentally whose prediction from theory has been challenging. Method of approach In this study the solid matrix of cartilage is modeled with a continuous fiber angular distribution, where fibers can only sustain tension, swelled by the osmotic pressure of a proteoglycan ground matrix. Results It is shown that this representation of cartilage can predict a number of observed phenomena in relation to the tissue’s equilibrium response to mechanical and osmotic loading, when flow-dependent and flow-independent viscoelastic effects have subsided. In particular, this model can predict the transition of Poisson’s ratio from very low values in compression (~0.02) to very high values in tension (~2.0). Most of these phenomena cannot be explained when using only three orthogonal fiber bundles to describe the tissue matrix, a common modeling assumption used to date. Conclusions The main picture emerging from this analysis is that the anisotropy of the fibrillar matrix of articular cartilage is intimately dependent on the mechanism of tensed fiber recruitment, in the manner suggested by our recent theoretical study (G. A. Ateshian. J Biomech Eng, 129(2):240-9, 2007). PMID:19449957

  7. A physically based numerical approach for modeling fracture-matrix interaction in fractured reservoirs

    SciTech Connect

    Wu, Yu-Shu; Pruess, Karsten

    2004-05-04

    Modeling fracture-matrix interaction within a multiple-phase flow system is a key issue for fractured reservoir simulation. Commonly used mathematical models for dealing with such interactions employ dual- or multiple-continuum concepts, in which fractures and matrix are represented as overlapping, different, but interconnected continua, described by parallel sets of conservation equations. The conventional single-point upstream weighting scheme is most commonly used to estimate flow mobility for fracture-matrix flow. However, such a scheme may have serious limitations or flaws, which lead to unphysical solutions or significant numerical errors. To overcome the limitations of the conventional upstream weighting scheme, this paper presents a physically based modeling approach for estimating physically correct relative permeability in calculating multiphase flow between fractures and the matrix, using continuity of capillary pressure at the fracture-matrix interface. The proposed approach has been implemented into two multiphase reservoir simulators and verified using analytical solutions and laboratory experimental data. The new method is demonstrated to be accurate, numerically efficient, and easy to implement in dual- or multiple-continuum reservoir simulators.

  8. Modeling Single Well Injection-Withdrawal (SWIW) Tests for Characterization of Complex Fracture-Matrix Systems

    SciTech Connect

    Cotte, F.P.; Doughty, C.; Birkholzer, J.

    2010-11-01

    The ability to reliably predict flow and transport in fractured porous rock is an essential condition for performance evaluation of geologic (underground) nuclear waste repositories. In this report, a suite of programs (TRIPOLY code) for calculating and analyzing flow and transport in two-dimensional fracture-matrix systems is used to model single-well injection-withdrawal (SWIW) tracer tests. The SWIW test, a tracer test using one well, is proposed as a useful means of collecting data for site characterization, as well as estimating parameters relevant to tracer diffusion and sorption. After some specific code adaptations, we numerically generated a complex fracture-matrix system for computation of steady-state flow and tracer advection and dispersion in the fracture network, along with solute exchange processes between the fractures and the porous matrix. We then conducted simulations for a hypothetical but workable SWIW test design and completed parameter sensitivity studies on three physical parameters of the rock matrix - namely porosity, diffusion coefficient, and retardation coefficient - in order to investigate their impact on the fracture-matrix solute exchange process. Hydraulic fracturing, or hydrofracking, is also modeled in this study, in two different ways: (1) by increasing the hydraulic aperture for flow in existing fractures and (2) by adding a new set of fractures to the field. The results of all these different tests are analyzed by studying the population of matrix blocks, the tracer spatial distribution, and the breakthrough curves (BTCs) obtained, while performing mass-balance checks and being careful to avoid some numerical mistakes that could occur. This study clearly demonstrates the importance of matrix effects in the solute transport process, with the sensitivity studies illustrating the increased importance of the matrix in providing a retardation mechanism for radionuclides as matrix porosity, diffusion coefficient, or retardation

  9. One-factor model for the cross-correlation matrix in the Vietnamese stock market

    NASA Astrophysics Data System (ADS)

    Nguyen, Quang

    2013-07-01

    Random matrix theory (RMT) has been applied to the analysis of the cross-correlation matrix of a financial time series. The most important findings of previous studies using this method are that the eigenvalue spectrum largely follows that of random matrices but the largest eigenvalue is at least one order of magnitude higher than the maximum eigenvalue predicted by RMT. In this work, we investigate the cross-correlation matrix in the Vietnamese stock market using RMT and find similar results to those of studies realized in developed markets (US, Europe, Japan) [9-18] as well as in other emerging markets[20,21,19,22]. Importantly, we found that the largest eigenvalue could be approximated by the product of the average cross-correlation coefficient and the number of stocks studied. We demonstrate this dependence using a simple one-factor model. The model could be extended to describe other characteristics of the realistic data.

  10. An extended standard model and its Higgs geometry from the matrix model

    NASA Astrophysics Data System (ADS)

    Steinacker, Harold C.; Zahn, Jochen

    2014-08-01

    We find a simple brane configuration in the IKKT matrix model which resembles the standard model at low energies, with a second Higgs doublet and right-handed neutrinos. The electroweak sector is realized geometrically in terms of two minimal fuzzy ellipsoids, which can be interpreted in terms of four point-branes in the extra dimensions. The electroweak Higgs connects these branes and is an indispensable part of the geometry. Fermionic would-be zero modes arise at the intersections with two larger branes, leading precisely to the correct chiral matter fields at low energy, along with right-handed neutrinos which can acquire a Majorana mass due to a Higgs singlet. The larger branes give rise to SU(3)_c, extended by U(1)_B and another U(1) which are anomalous at low energies and expected to disappear. At higher energies, mirror fermions and additional fields arise, completing the full {N}=4 supersymmetry. The brane configuration is a solution of the model, assuming a suitable effective potential and a non-linear stabilization of the singlet Higgs. The basic results can be carried over to {N}=4 SU(N) super Yang-Mills on ordinary Minkowski space with sufficiently large N.

  11. Application of nonequilibrium fracture matrix model in simulating reactive contaminant transport through fractured porous media

    NASA Astrophysics Data System (ADS)

    Joshi, Nitin; Ojha, C. S. P.; Sharma, P. K.; Madramootoo, Chandra A.

    2015-01-01

    Nonequilibrium and nonlinear sorption of the contaminants in the fractured porous media could significantly influence the shape of the breakthrough curve (BTC). For the fracture-matrix system, there are very few studies which consider these processes. In this study, the nonequilibrium fracture-matrix model with two different nonlinear sorption isotherms, namely nonlinear Freundlich and Langmuir sorption isotherms were developed. The effect of sorption nonlinearity and nonequilibrium conditions on the shape of the BTC was studied using the temporal moments. The developed models along with the linear equilibrium, linear nonequilibrium fracture matrix models, and the multirate mass transfer model were used to simulate the BTC, which were compared with the experimental data available in the literature. Both sorption nonequilibrium and nonlinearity were found to significantly influence the shape of the BTC. Presence of sorption nonlinearity reduces the solute spreading, whereas presence of nonequilibrium conditions increases the solute spreading. Considering the sorption nonequilibrium along with the sorption nonlinearity leads to an improved simulation of the BTC. The nonequilibrium nonlinear sorption models could simulate the extended BTC tailing resulting from sorption nonlinearity and rate-limited interaction in the fracture-matrix system.

  12. Numerical Modeling on Two phase Fluid flow in a Coupled Fracture-Skin-Matrix System

    NASA Astrophysics Data System (ADS)

    Valsala Kumari, R.; G, S. K.

    2015-12-01

    Multiphase flow modeling studies below the ground surface is very essential for designing suitable remediation strategies for contaminated aquifers and for the development of petroleum and geothermal reservoirs. Presence of fractured bedrock beneath the ground surface will make multiphase flow process more complex due to its highly heterogeneous nature. A major challenge in modeling flow within a fractured rock is to capture the interaction between the high permeability fracture and the low permeability rock-matrix. In some instances, weathering and mineral depositions will lead to formation of an additional layer named fracture-skin at the fracture-matrix interface. Porosity and permeability of fracture-skin may significantly vary from the adjacent rock matrix and this variation will result in different flow and transport behavior within the fracture-skin. In the present study, an attempt has been made to model simultaneous flow of two immiscible phases (water and LNAPL) in a saturated coupled fracture-skin-matrix system. A fully-implicit finite difference model has been developed to simulate the variation of pressure and saturation of fluid phases along the fracture and within the rock-matrix. Sensitivity studies have been done to analyze the effect of change of various fracture-skin parameters such as porosity, diffusion coefficient and thickness on pressure and saturation distribution of both wetting and non-wetting fluid phases. It can be concluded from the study that the presence of fracture-skin is significantly affecting the fluid flow at the fracture-matrix interface and it can also be seen from the study that the flow behavior of both fluid phases is sensitive to fracture-skin parameters.

  13. Modelling of the Scattering by a Smooth Dielectric Cylinder: Study of the Complex Scattering Matrix using Two Different Models

    NASA Astrophysics Data System (ADS)

    Thirion, L.; Dahon, C.; Lefevre, A.; Chenerie, I.; Ferro-Famil, L.; Titin-Schnaider, C.

    2003-04-01

    The interpretation of SAR data remains particularly difficult in the case of forests. Interferometric or/and polarimetric studies may enable us to retrieve some characteristics of the forest and identify the relevant scattering mechanisms in- volved in the global scattering phenomenon. A lot of numerical models have been developed to make the retrieval of such complex scenes easier. Both interferometry and polarimetry require a good knowledge of the scattering matrix, which is studied here for a single scatterer with a focusing on trunks, branches and needles, which are generally modelled by cylin- ders. The scattering matrix is simulated with two different commonly used models, based on semi-exact computations. The complex scattering matrix is computed for several local mechanisms involved in the global scattering by forested areas. Significantly results are found, pointing out that such studies are necessary before focusing on forest scattering modelling.

  14. The accuracy of matrix population model projections for coniferous trees in the Sierra Nevada, California

    USGS Publications Warehouse

    van Mantgem, P.J.; Stephenson, N.L.

    2005-01-01

    1 We assess the use of simple, size-based matrix population models for projecting population trends for six coniferous tree species in the Sierra Nevada, California. We used demographic data from 16 673 trees in 15 permanent plots to create 17 separate time-invariant, density-independent population projection models, and determined differences between trends projected from initial surveys with a 5-year interval and observed data during two subsequent 5-year time steps. 2 We detected departures from the assumptions of the matrix modelling approach in terms of strong growth autocorrelations. We also found evidence of observation errors for measurements of tree growth and, to a more limited degree, recruitment. Loglinear analysis provided evidence of significant temporal variation in demographic rates for only two of the 17 populations. 3 Total population sizes were strongly predicted by model projections, although population dynamics were dominated by carryover from the previous 5-year time step (i.e. there were few cases of recruitment or death). Fractional changes to overall population sizes were less well predicted. Compared with a null model and a simple demographic model lacking size structure, matrix model projections were better able to predict total population sizes, although the differences were not statistically significant. Matrix model projections were also able to predict short-term rates of survival, growth and recruitment. Mortality frequencies were not well predicted. 4 Our results suggest that simple size-structured models can accurately project future short-term changes for some tree populations. However, not all populations were well predicted and these simple models would probably become more inaccurate over longer projection intervals. The predictive ability of these models would also be limited by disturbance or other events that destabilize demographic rates. ?? 2005 British Ecological Society.

  15. LS-DYNA Implementation of Polymer Matrix Composite Model Under High Strain Rate Impact

    NASA Technical Reports Server (NTRS)

    Zheng, Xia-Hua; Goldberg, Robert K.; Binienda, Wieslaw K.; Roberts, Gary D.

    2003-01-01

    A recently developed constitutive model is implemented into LS-DYNA as a user defined material model (UMAT) to characterize the nonlinear strain rate dependent behavior of polymers. By utilizing this model within a micromechanics technique based on a laminate analogy, an algorithm to analyze the strain rate dependent, nonlinear deformation of a fiber reinforced polymer matrix composite is then developed as a UMAT to simulate the response of these composites under high strain rate impact. The models are designed for shell elements in order to ensure computational efficiency. Experimental and numerical stress-strain curves are compared for two representative polymers and a representative polymer matrix composite, with the analytical model predicting the experimental response reasonably well.

  16. Fracture-Based Mesh Size Requirements for Matrix Cracks in Continuum Damage Mechanics Models

    NASA Technical Reports Server (NTRS)

    Leone, Frank A.; Davila, Carlos G.; Mabson, Gerald E.; Ramnath, Madhavadas; Hyder, Imran

    2017-01-01

    This paper evaluates the ability of progressive damage analysis (PDA) finite element (FE) models to predict transverse matrix cracks in unidirectional composites. The results of the analyses are compared to closed-form linear elastic fracture mechanics (LEFM) solutions. Matrix cracks in fiber-reinforced composite materials subjected to mode I and mode II loading are studied using continuum damage mechanics and zero-thickness cohesive zone modeling approaches. The FE models used in this study are built parametrically so as to investigate several model input variables and the limits associated with matching the upper-bound LEFM solutions. Specifically, the sensitivity of the PDA FE model results to changes in strength and element size are investigated.

  17. The Data Collection Matrix Model: A Tool for Functional Area and Program Evaluation.

    ERIC Educational Resources Information Center

    Coker, Dana Rosenberg; Friedel, Janice Nahra

    1991-01-01

    The data collection matrix makes possible the integration of functional area data from numerous assessment sources and presentation of the information in a unified composite report. This model is discussed in relation to the various assessment instruments and the evaluation of functional areas and programs in colleges and universities. (Author/MSE)

  18. Micromechanical Modeling for Tensile Behaviour of Carbon Fiber - Reinforced Ceramic - Matrix Composites

    NASA Astrophysics Data System (ADS)

    Longbiao, Li

    2015-12-01

    The stress-strain curves of fiber - reinforced ceramic - matrix composites (CMCs) exhibit obvious non-linear behaviour under tensile loading. The occurrence of multiple damage mechanisms, i.e., matrix multicracking, fiber/matrix interface debonding and fibers fracture, is the mainly reason for the non-linear characteristic. The micromechanics approach has been developed to predict the tensile stress-strain curves of unidirectional, cross-ply and woven CMCs. The shear-lag model was used to describe the micro stress field of the damaged composite. The damage models were used to determine the evolution of micro damage parameters, i.e., matrix crack spacing, interface debonded length and broken fibers fraction. By combining the shear-lag model with damage models and considering the effect of transverse multicracking in the 90° plies or transverse yarns in cross-ply or woven CMCs, the tensile stress-strain curves of unidirectional, cross-ply, 2D and 2.5D woven CMCs have been predicted. The results agreed with experimental data.

  19. Demographic matrix model for informing swallow-wort (Vincetoxicum spp.) biological control

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Demographic matrix modeling of plant populations can be a powerful tool to identify key life stage transitions that contribute the most to population growth of an invasive plant and hence should be targeted for disruption (weak links) by biological control and/or other control tactics. Therefore, t...

  20. Effect of matrix elasticity on the continuous foaming of food models.

    PubMed

    Narchi, I; Vial, Ch; Djelveh, G

    2008-12-01

    The aim is to understand the effect of matrix elasticity on continuous foaming using food models based on glucose syrup. This was modified by adding polyacrylamide (PAA) with 2% whey protein isolate (WPI) or Tween 80 as foaming agents. Foaming was conducted in a stirred column. Rotation speed N and gas-to-liquid flow ratio (G/L) were varied. Overrun, average bubble size d (32), texture and stability were measured using densimetry, image analysis, and rheometry, respectively. Experimental results showed that 0.01% PAA did not modify the viscosity of 2% WPI models, but conferred low elastic behavior. PAA (0.05%) doubled matrix viscosity and drastically increased elasticity. The increase of elasticity became slower for further PAA addition. Foaming experiments demonstrated that theoretical overrun could not be achieved for inelastic WPI models in two cases: for high viscosity and low N, as dispersion effectiveness was reduced; for high G/L and N because of enhanced coalescence. Matrix elasticity was shown to increase overrun at constant viscosity for high G/L by enhancing interface stabilization. However, in elastic models, gas dispersion was more difficult and d (32) was higher than in inelastic fluids of similar viscosity. Finally, when the limiting step was dispersion, foaming was shown to be negatively affected by matrix elasticity.

  1. Nucleon statistics in holographic QCD: Aharonov-Bohm effect in a matrix model

    SciTech Connect

    Hashimoto, Koji; Iizuka, Norihiro

    2010-11-15

    We show that the Aharonov-Bohm effect in the nuclear matrix model [K. Hashimoto, N. Iizuka, and P. Yi, J. High Energy Phys. 10 (2010), 3.] derives the statistical nature of nucleons in holographic QCD. For N{sub c}=odd (even), the nucleon is shown to be a fermion (boson).

  2. Nucleon statistics in holographic QCD: Aharonov-Bohm effect in a matrix model

    NASA Astrophysics Data System (ADS)

    Hashimoto, Koji; Iizuka, Norihiro

    2010-11-01

    We show that the Aharonov-Bohm effect in the nuclear matrix model [K. Hashimoto, N. Iizuka, and P. Yi, J. High Energy Phys.JHEPFG1029-8479 10 (2010), 3.10.1007/JHEP10(2010)003] derives the statistical nature of nucleons in holographic QCD. For Nc=odd (even), the nucleon is shown to be a fermion (boson).

  3. Matrix models for size-structured populations: unrealistic fast growth or simply diffusion?

    PubMed

    Picard, Nicolas; Liang, Jingjing

    2014-01-01

    Matrix population models are widely used to study population dynamics but have been criticized because their outputs are sensitive to the dimension of the matrix (or, equivalently, to the class width). This sensitivity is concerning for the population growth rate (λ) because this is an intrinsic characteristic of the population that should not depend on the model specification. It has been suggested that the sensitivity of λ to matrix dimension was linked to the existence of fast pathways (i.e. the fraction of individuals that systematically move up a class), whose proportion increases when class width increases. We showed that for matrix population models with growth transition only from class i to class i + 1, λ was independent of the class width when the mortality and the recruitment rates were constant, irrespective of the growth rate. We also showed that if there were indeed fast pathways, there were also in about the same proportion slow pathways (i.e. the fraction of individuals that systematically remained in the same class), and that they jointly act as a diffusion process (where diffusion here is the movement in size of an individual whose size increments are random according to a normal distribution with mean zero). For 53 tree species from a tropical rain forest in the Central African Republic, the diffusion resulting from common matrix dimensions was much stronger than would be realistic. Yet, the sensitivity of λ to matrix dimension for a class width in the range 1-10 cm was small, much smaller than the sampling uncertainty on the value of λ. Moreover, λ could either increase or decrease when class width increased depending on the species. Overall, even if the class width should be kept small enough to limit diffusion, it had little impact on the estimate of λ for tree species.

  4. Modeling Single Well Injection-Withdrawal (SWIW) Tests for Characterization of Complex Fracture-Matrix Systems

    NASA Astrophysics Data System (ADS)

    Cotte, F.; Doughty, C.; Birkholzer, J. T.

    2010-12-01

    An essential condition for performance evaluation of enhanced geothermal systems (EGS) resides in the ability to reliably predict fluid flow and heat transport in fractured porous rocks, where fast convection-dispersive transport through the fracture network can be strongly affected by heat conduction into the adjacent rock matrix. SWIW tests are single-well tracer tests that involve an initial period of fluid and tracer injection followed by a period of fluid withdrawal. As a result of the flow field reversal, the measured breakthrough curves tend to be less sensitive to advective heterogeneities and more sensitive to matrix diffusion and sorption, making this method very valuable in characterizing fracture-matrix interaction and evaluating matrix properties. In particular, we propose using SWIW tests before and after hydrofracking operations, to help assess the means by which hydrofracking increases permeability and enhances fracture-matrix interaction. In the present study, we have modeled single-well injection-withdrawal (SWIW) tests for non-sorbing and sorbing tracers, using the mixed Eulerian-Lagrangian transport simulator TRIPOLY, which solves tracer advection and dispersion in fracture networks together with solute exchange processes between the fractures and the porous matrix. Our simulations were conducted for hypothetical but workable SWIW test designs considering a variety of statistically generated 2D fracture-matrix systems. Parameter sensitivity studies were completed on three physical parameters of the rock matrix, namely porosity, diffusion coefficient and retardation coefficient, in order to investigate their impact on the fracture-matrix solute exchange process. Hydraulic fracturing, or hydrofracking, was modeled in two different ways, one by increasing the fracture aperture for flow and the other one by adding a new set of fractures to the fracture network. The results of all these different tests were analyzed by studying the population of

  5. A New Equation Solver for Modeling Turbulent Flow in Coupled Matrix-Conduit Flow Models.

    PubMed

    Hubinger, Bernhard; Birk, Steffen; Hergarten, Stefan

    2016-07-01

    Karst aquifers represent dual flow systems consisting of a highly conductive conduit system embedded in a less permeable rock matrix. Hybrid models iteratively coupling both flow systems generally consume much time, especially because of the nonlinearity of turbulent conduit flow. To reduce calculation times compared to those of existing approaches, a new iterative equation solver for the conduit system is developed based on an approximated Newton-Raphson expression and a Gauß-Seidel or successive over-relaxation scheme with a single iteration step at the innermost level. It is implemented and tested in the research code CAVE but should be easily adaptable to similar models such as the Conduit Flow Process for MODFLOW-2005. It substantially reduces the computational effort as demonstrated by steady-state benchmark scenarios as well as by transient karst genesis simulations. Water balance errors are found to be acceptable in most of the test cases. However, the performance and accuracy may deteriorate under unfavorable conditions such as sudden, strong changes of the flow field at some stages of the karst genesis simulations.

  6. [Experimental study of the collagen matrix for increase the gums using a 3D-modeling].

    PubMed

    Baulin, I M; Badalyan, V A; Ryakhovsky, A N

    2015-01-01

    In an experimental study on mini-pigs demonstrated that the use of collagen matrix Mucograft open method leads to the formation of mature connective tissue around the implants, more pronounced after 70 days, and the width of attached mucosa already 45th day (from 4.4 ± 0.3 to 7.7 ± 0.5 mm) is comparable to that of free gingival graft. Three-dimensional computer modeling of jaws experimental animals showed the soft tissue augmentation by 0.8 ± 0.1 cm3 after use of collagen matrix Mucograft and 1.1 ± 0.12 cm3 after free gingival graft.

  7. The effect of stochiastic technique on estimates of population viability from transition matrix models

    USGS Publications Warehouse

    Kaye, T.N.; Pyke, David A.

    2003-01-01

    Population viability analysis is an important tool for conservation biologists, and matrix models that incorporate stochasticity are commonly used for this purpose. However, stochastic simulations may require assumptions about the distribution of matrix parameters, and modelers often select a statistical distribution that seems reasonable without sufficient data to test its fit. We used data from long-term (5a??10 year) studies with 27 populations of five perennial plant species to compare seven methods of incorporating environmental stochasticity. We estimated stochastic population growth rate (a measure of viability) using a matrix-selection method, in which whole observed matrices were selected at random at each time step of the model. In addition, we drew matrix elements (transition probabilities) at random using various statistical distributions: beta, truncated-gamma, truncated-normal, triangular, uniform, or discontinuous/observed. Recruitment rates were held constant at their observed mean values. Two methods of constraining stage-specific survival to a??100% were also compared. Different methods of incorporating stochasticity and constraining matrix column sums interacted in their effects and resulted in different estimates of stochastic growth rate (differing by up to 16%). Modelers should be aware that when constraining stage-specific survival to 100%, different methods may introduce different levels of bias in transition element means, and when this happens, different distributions for generating random transition elements may result in different viability estimates. There was no species effect on the results and the growth rates derived from all methods were highly correlated with one another. We conclude that the absolute value of population viability estimates is sensitive to model assumptions, but the relative ranking of populations (and management treatments) is robust. Furthermore, these results are applicable to a range of perennial plants and

  8. An analytical model for particulate reinforced composites (PRCs) taking account of particle debonding and matrix cracking

    NASA Astrophysics Data System (ADS)

    Jiang, Yunpeng

    2016-10-01

    In this work, a simple micromechanics-based model was developed to describe the overall stress-strain relations of particulate reinforced composites (PRCs), taking into account both particle debonding and matrix cracking damage. Based on the secant homogenization frame, the effective compliance tensor could be firstly given for the perfect composites without any damage. The progressive interface debonding damage is controlled by a Weibull probability function, and then the volume fraction of detached particles is involved in the equivalent compliance tensor to account for the impact of particle debonding. The matrix cracking was introduced in the present model to embody the stress softening stage in the deformation of PRCs. The analytical model was firstly verified by comparing with the corresponding experiment, and then parameter analyses were conducted. This modeling will shed some light on optimizing the microstructures in effectively improving the mechanical behaviors of PRCs.

  9. Massive quiver matrix models for massive charged particles in AdS

    SciTech Connect

    Asplund, Curtis T.; Denef, Frederik; Dzienkowski, Eric

    2016-01-11

    Here, we present a new class of N = 4 supersymmetric quiver matrix models and argue that it describes the stringy low-energy dynamics of internally wrapped D-branes in four-dimensional anti-de Sitter (AdS) flux compactifications. The Lagrangians of these models differ from previously studied quiver matrix models by the presence of mass terms, associated with the AdS gravitational potential, as well as additional terms dictated by supersymmetry. These give rise to dynamical phenomena typically associated with the presence of fluxes, such as fuzzy membranes, internal cyclotron motion and the appearance of confining strings. We also show how these models can be obtained by dimensional reduction of four-dimensional supersymmetric quiver gauge theories on a three-sphere.

  10. Massive quiver matrix models for massive charged particles in AdS

    DOE PAGES

    Asplund, Curtis T.; Denef, Frederik; Dzienkowski, Eric

    2016-01-11

    Here, we present a new class of N = 4 supersymmetric quiver matrix models and argue that it describes the stringy low-energy dynamics of internally wrapped D-branes in four-dimensional anti-de Sitter (AdS) flux compactifications. The Lagrangians of these models differ from previously studied quiver matrix models by the presence of mass terms, associated with the AdS gravitational potential, as well as additional terms dictated by supersymmetry. These give rise to dynamical phenomena typically associated with the presence of fluxes, such as fuzzy membranes, internal cyclotron motion and the appearance of confining strings. We also show how these models can bemore » obtained by dimensional reduction of four-dimensional supersymmetric quiver gauge theories on a three-sphere.« less

  11. R-matrix calculations of electron molecule collision data for plasma models

    NASA Astrophysics Data System (ADS)

    Tennyson, Jonathan

    2016-09-01

    Models of low-pressure plasma require electron collision cross sections for many processes. For transient molecular species, almost none of these data are available from laboratory measurements so theory has to be the chosen means of providing the necessary information. The R-matrix method is a well-established fully quantal procedure for computing low-energy electron-collision cross sections. The R-matrix calculations using the UK Molecular R-matrix codes (UKRMol), which are run by the Quantemol-N expert system, are being employed to provide a wide range of collision cross sections. These are augmented by use of suitable high-energy approximations, such as BEB for ionisation, and a novel procedure to give branching ratios for the fragmentation pattern following electron impact ionisation and electron impact dissociation. Examples, such as recently generated complete cross section sets for the molecules NF, NF and NF, will be given at the meeting.

  12. A model for the control of DNA integrity by the sperm nuclear matrix

    PubMed Central

    Gawecka, Joanna E; Ribas-Maynou, Jordi; Benet, Jordi; Ward, W Steven

    2015-01-01

    The highly condensed chromatin of mammalian spermatozoa is usually considered to be biologically inert before fertilization. However, we have demonstrated that even in this compacted state, sperm chromatin is subject to degradation at open configurations associated with the nuclear matrix through a process we have termed sperm chromatin fragmentation (SCF). This suggests that a mechanism exists to monitor the health of spermatozoa during transit through the male reproductive tract and to destroy the genome of defective sperm cells. The site of DNA damage in SCF, the matrix attachment sites, are the same that we hypothesize initiate DNA synthesis in the zygote. When sperm that have damaged DNA are injected into the oocyte, the newly created zygote responds by delaying DNA synthesis in the male pronucleus and, if the damage is severe enough, arresting the embryo's development. Here we present a model for paternal DNA regulation by the nuclear matrix that begins during sperm maturation and continues through early embryonic development. PMID:25926613

  13. Topological Control of Extracellular Matrix Growth: A Native-Like Model for Cell Morphodynamics Studies.

    PubMed

    Caballero, David; Samitier, Josep

    2017-02-01

    The interaction of cells with their natural environment influences a large variety of cellular phenomena, including cell adhesion, proliferation, and migration. The complex extracellular matrix network has challenged the attempts to replicate in vitro the heterogeneity of the cell environment and has threatened, in general, the relevance of in vitro studies. In this work, we describe a new and extremely versatile approach to generate native-like extracellular matrices with controlled morphologies for the in vitro study of cellular processes. This general approach combines the confluent culture of fibroblasts with microfabricated guiding templates to direct the three-dimensional growth of well-defined extracellular networks which recapitulate the structural and biomolecular complexity of features typically found in vivo. To evaluate its performance, we studied fundamental cellular processes, including cell cytoskeleton organization, cell-matrix adhesion, proliferation, and protrusions morphodynamics. In all cases, we found striking differences depending on matrix architecture and, in particular, when compared to standard two-dimensional environments. We also assessed whether the engineered matrix networks influenced cell migration dynamics and locomotion strategy, finding enhanced migration efficiency for cells seeded on aligned matrices. Altogether, our methodology paves the way to the development of high-performance models of the extracellular matrix for potential applications in tissue engineering, diagnosis, or stem-cell biology.

  14. Modeling and life prediction methodology for Titanium Matrix Composites subjected to mission profiles

    NASA Technical Reports Server (NTRS)

    Mirdamadi, M.; Johnson, W. S.

    1994-01-01

    Titanium matrix composites (TMC) are being evaluated as structural materials for elevated temperature applications in future generation hypersonic vehicles. In such applications, TMC components are subjected to complex thermomechanical loading profiles at various elevated temperatures. Therefore, thermomechanical fatigue (TMF) testing, using a simulated mission profile, is essential for evaluation and development of life prediction methodologies. The objective of the research presented in this paper was to evaluate the TMF response of the (0/90)2s SCS-6/Timetal-21S subjected to a generic hypersonic flight profile and its portions with a temperature ranging from -130 C to 816 C. It was found that the composite modulus, prior to rapid degradation, had consistent values for all the profiles tested. A micromechanics based analysis was used to predict the stress-strain response of the laminate and of the constituents in each ply during thermomechanical loading conditions by using only constituent properties as input. The fiber was modeled as elastic with transverse orthotropic and temperature dependent properties. The matrix was modeled using a thermoviscoplastic constitutive relation. In the analysis, the composite modulus degradation was assumed to result from matrix cracking and was modeled by reducing the matrix modulus. Fatigue lives of the composite subjected to the complex generic hypersonic flight profile were well correlated using the predicted stress in 0 degree fibers.

  15. Modeling and life prediction methodology for Titanium Matrix Composites subjected to mission profiles

    SciTech Connect

    Mirdamadi, M.; Johnson, W.S.

    1994-08-01

    Titanium matrix composites (TMC) are being evaluated as structural materials for elevated temperature applications in future generation hypersonic vehicles. In such applications, TMC components are subjected to complex thermomechanical loading profiles at various elevated temperatures. Therefore, thermomechanical fatigue (TMF) testing, using a simulated mission profile, is essential for evaluation and development of life prediction methodologies. The objective of the research presented in this paper was to evaluate the TMF response of the (0/90)2s SCS-6/Timetal-21S subjected to a generic hypersonic flight profile and its portions with a temperature ranging from -130 C to 816 C. It was found that the composite modulus, prior to rapid degradation, had consistent values for all the profiles tested. A micromechanics based analysis was used to predict the stress-strain response of the laminate and of the constituents in each ply during thermomechanical loading conditions by using only constituent properties as input. The fiber was modeled as elastic with transverse orthotropic and temperature dependent properties. The matrix was modeled using a thermoviscoplastic constitutive relation. In the analysis, the composite modulus degradation was assumed to result from matrix cracking and was modeled by reducing the matrix modulus. Fatigue lives of the composite subjected to the complex generic hypersonic flight profile were well correlated using the predicted stress in 0 degree fibers.

  16. Model Determined for Predicting Fatigue Lives of Metal Matrix Composites Under Mean Stresses

    NASA Technical Reports Server (NTRS)

    Lerch, Bradley

    1997-01-01

    Aircraft engine components invariably are subjected to mean stresses over and above the cyclic loads. In monolithic materials, it has been observed that tensile mean stresses are detrimental and compressive mean stresses are beneficial to fatigue life in comparison to a base of zero mean stress. Several mean stress models exist for monolithic metals, but each differ quantitatively in the extent to which detrimental or beneficial effects are ascribed. There have been limited attempts to apply these models to metal matrix composites. At the NASA Lewis Research Center, several mean stress models--the Smith-Watson- Topper, Walker, Normalized Goodman, and Soderberg models--were examined for applicability to this class of composite materials. The Soderberg approach, which normalizes the mean stress to a 0.02-percent yield strength, was shown to best represent the effect of mean stresses over the range covered. The other models varied significantly in their predictability and often failed to predict the composite behavior at very high tensile mean stresses. This work is the first to systematically demonstrate the influence of mean stresses on metal matrix composites and model their effects. Attention also was given to fatigue-cracking mechanisms in the Ti-15-3 matrix and to micromechanics analyses of mean stress effects.

  17. A differential CDM model for fatigue of unidirectional metal matrix composites

    NASA Technical Reports Server (NTRS)

    Arnold, S. M.; Kruch, S.

    1992-01-01

    A multiaxial, isothermal, continuum damage mechanics (CDM) model for fatigue of a unidirectional metal matrix composite volume element is presented. The model is phenomenological, stress based, and assumes a single scalar internal damage variable, the evolution of which is anisotropic. The development of the fatigue damage model, (i.e., evolutionary law) is based on the definition of an initially transversely isotropic fatigue limit surface, a static fracture surface, and a normalized stress amplitude function. The anisotropy of these surfaces and function, and therefore the model, is defined through physically meaningful invariants reflecting the local stress and material orientation. This transversely isotropic model is shown, when taken to it's isotropic limit, to directly simplify to a previously developed and validated isotropic fatigue continuum damage model. Results of a nondimensional parametric study illustrate (1) the flexibility of the present formulation in attempting to characterize a class of composite materials, and (2) the capability of the formulation in predicting anticipated qualitative trends in the fatigue behavior of unidirectional metal matrix composites. Also, specific material parameters representing an initial characterization of the composite system SiC/Ti 15-3 and the matrix material (Ti 15-3) are reported.

  18. Transition probabilities matrix of Markov Chain in the fatigue crack growth model

    NASA Astrophysics Data System (ADS)

    Nopiah, Zulkifli Mohd; Januri, Siti Sarah; Ariffin, Ahmad Kamal; Masseran, Nurulkamal; Abdullah, Shahrum

    2016-10-01

    Markov model is one of the reliable method to describe the growth of the crack from the initial until fracture phase. One of the important subjects in the crack growth models is to obtain the transition probability matrix of the fatigue. Determining probability transition matrix is important in Markov Chain model for describing probability behaviour of fatigue life in the structure. In this paper, we obtain transition probabilities of a Markov chain based on the Paris law equation to describe the physical meaning of fatigue crack growth problem. The results show that the transition probabilities are capable to calculate the probability of damage in the future with the possibilities of comparing each stage between time.

  19. Multiphase modelling of tumour growth and extracellular matrix interaction: mathematical tools and applications.

    PubMed

    Preziosi, Luigi; Tosin, Andrea

    2009-04-01

    Resorting to a multiphase modelling framework, tumours are described here as a mixture of tumour and host cells within a porous structure constituted by a remodelling extracellular matrix (ECM), which is wet by a physiological extracellular fluid. The model presented in this article focuses mainly on the description of mechanical interactions of the growing tumour with the host tissue, their influence on tumour growth, and the attachment/detachment mechanisms between cells and ECM. Starting from some recent experimental evidences, we propose to describe the interaction forces involving the extracellular matrix via some concepts coming from viscoplasticity. We then apply the model to the description of the growth of tumour cords and the formation of fibrosis.

  20. Data-resolution matrix and model-resolution matrix for Rayleigh-wave inversion using a damped least-squares method

    USGS Publications Warehouse

    Xia, J.; Miller, R.D.; Xu, Y.

    2008-01-01

    Inversion of multimode surface-wave data is of increasing interest in the near-surface geophysics community. For a given near-surface geophysical problem, it is essential to understand how well the data, calculated according to a layered-earth model, might match the observed data. A data-resolution matrix is a function of the data kernel (determined by a geophysical model and a priori information applied to the problem), not the data. A data-resolution matrix of high-frequency (>2 Hz) Rayleigh-wave phase velocities, therefore, offers a quantitative tool for designing field surveys and predicting the match between calculated and observed data. We employed a data-resolution matrix to select data that would be well predicted and we find that there are advantages of incorporating higher modes in inversion. The resulting discussion using the data-resolution matrix provides insight into the process of inverting Rayleigh-wave phase velocities with higher-mode data to estimate S-wave velocity structure. Discussion also suggested that each near-surface geophysical target can only be resolved using Rayleigh-wave phase velocities within specific frequency ranges, and higher-mode data are normally more accurately predicted than fundamental-mode data because of restrictions on the data kernel for the inversion system. We used synthetic and real-world examples to demonstrate that selected data with the data-resolution matrix can provide better inversion results and to explain with the data-resolution matrix why incorporating higher-mode data in inversion can provide better results. We also calculated model-resolution matrices in these examples to show the potential of increasing model resolution with selected surface-wave data. ?? Birkhaueser 2008.

  1. Deformed Matrix Models, Supersymmetric Lattice Twists and N=1/4 Supersymmetry

    SciTech Connect

    Unsal, Mithat

    2008-09-24

    A manifestly supersymmetric nonperturbative matrix regularization for a twisted version of N = (8, 8) theory on a curved background (a two-sphere) is constructed. Both continuum and the matrix regularization respect four exact scalar supersymmetries under a twisted version of the supersymmetry algebra. We then discuss a succinct Q = 1 deformed matrix model regularization of N = 4 SYM in d = 4, which is equivalent to a non-commutative A*{sub 4} orbifold lattice formulation. Motivated by recent progress in supersymmetric lattices, we also propose a N = 1/4 supersymmetry preserving deformation of N = 4 SYM theory on R{sup 4}. In this class of N = 1/4 theories, both the regularized and continuum theory respect the same set of (scalar) supersymmetry. By using the equivalence of the deformed matrix models with the lattice formulations, we give a very simple physical argument on why the exact lattice supersymmetry must be a subset of scalar subalgebra. This argument disagrees with the recent claims of the link approach, for which we give a new interpretation.

  2. Potential-model calculation of an order-v2 nonrelativistic QCD matrix element

    NASA Astrophysics Data System (ADS)

    Bodwin, Geoffrey T.; Kang, Daekyoung; Lee, Jungil

    2006-07-01

    We present two methods for computing dimensionally regulated nonrelativistic QCD heavy-quarkonium matrix elements that are related to the second derivative of the heavy-quarkonium wave function at the origin. The first method makes use of a hard-cutoff regulator as an intermediate step and requires knowledge only of the heavy-quarkonium wave function. It involves a significant cancellation that is an obstacle to achieving high numerical accuracy. The second method is more direct and yields a result that is identical to the Gremm-Kapustin relation, but it is limited to use in potential models. It can be generalized to the computation of matrix elements of higher order in the heavy-quark velocity and can be used to resum the contributions to decay and production rates that are associated with those matrix elements. We apply these methods to the Cornell potential model and compute a matrix element for the J/ψ state that appears in the leading relativistic correction to the production and decay of that state through the color-singlet quark-antiquark channel.

  3. Development of a hybrid wave based-transfer matrix model for sound transmission analysis.

    PubMed

    Dijckmans, A; Vermeir, G

    2013-04-01

    In this paper, a hybrid wave based-transfer matrix model is presented that allows for the investigation of the sound transmission through finite multilayered structures placed between two reverberant rooms. The multilayered structure may consist of an arbitrary configuration of fluid, elastic, or poro-elastic layers. The field variables (structural displacements and sound pressures) are expanded in terms of structural and acoustic wave functions. The boundary and continuity conditions in the rooms determine the participation factors in the pressure expansions. The displacement of the multilayered structure is determined by the mechanical impedance matrix, which gives a relation between the pressures and transverse displacements at both sides of the structure. The elements of this matrix are calculated with the transfer matrix method. First, the hybrid model is numerically validated. Next a comparison is made with sound transmission loss measurements of a hollow brick wall and a sandwich panel. Finally, numerical simulations show the influence of structural damping, room dimensions and plate dimensions on the sound transmission loss of multilayered structures.

  4. Differential continuum damage mechanics models for creep and fatigue of unidirectional metal matrix composites

    NASA Technical Reports Server (NTRS)

    Arnold, S. M.; Kruch, S.

    1991-01-01

    Three multiaxial isothermal continuum damage mechanics models for creep, fatigue, and creep/fatigue interaction of a unidirectional metal matrix composite volume element are presented, only one of which will be discussed in depth. Each model is phenomenological and stress based, with varying degrees of complexity to accurately predict the initiation and propagation of intergranular and transgranular defects over a wide range of loading conditions. The development of these models is founded on the definition of an initially transversely isotropic fatigue limit surface, static fracture surface, normalized stress amplitude function and isochronous creep damage failure surface, from which both fatigue and creep damage evolutionary laws can be obtained. The anisotropy of each model is defined through physically meaningful invariants reflecting the local stress and material orientation. All three transversely isotropic models have been shown, when taken to their isotropic limit, to directly simplify to previously developed and validated creep and fatigue continuum damage theories. Results of a nondimensional parametric study illustrate (1) the flexibility of the present formulation when attempting to characterize a large class of composite materials, and (2) its ability to predict anticipated qualitative trends in the fatigue behavior of unidirectional metal matrix composites. Additionally, the potential for the inclusion of various micromechanical effects (e.g., fiber/matrix bond strength, fiber volume fraction, etc.), into the phenomenological anisotropic parameters is noted, as well as a detailed discussion regarding the necessary exploratory and characterization experiments needed to utilize the featured damage theories.

  5. Mathematical model of water transport in Bacon and alkaline matrix-type hydrogen-oxygen fuel cells

    NASA Technical Reports Server (NTRS)

    Prokopius, P. R.; Easter, R. W.

    1972-01-01

    Based on general mass continuity and diffusive transport equations, a mathematical model was developed that simulates the transport of water in Bacon and alkaline-matrix fuel cells. The derived model was validated by using it to analytically reproduce various Bacon and matrix-cell experimental water transport transients.

  6. The Development of Multicultural Counselling Competencies (MCC) Training Module Based on MCC Matrix Model by Sue et al. (1992)

    ERIC Educational Resources Information Center

    Anuar, Azad Athahiri; Rozubi, Norsayyidatina Che; Abdullah, Haslee Sharil

    2015-01-01

    The aims of this study were to develop and validate a MCC training module for trainee counselor based on MCC matrix model by Sue et al. (1992). This module encompassed five sub modules and 11 activities developed along the concepts and components of the MCC matrix model developed by Sue, Arredondo dan McDavis (1992). The design method used in this…

  7. On the Critical Behavior of Hermitian f-MATRIX Models in the Double Scaling Limit with f ≥ 3

    NASA Astrophysics Data System (ADS)

    Balaska, S.; Maeder, J.; Rühl, W.

    An algorithm for the isolation of any singularity of f-matrix models in the double scaling limit is presented. In particular it is proved by construction that only those universality classes exist that are known from two-matrix models.

  8. B(s) 0-mixing matrix elements from lattice QCD for the Standard Model and beyond

    NASA Astrophysics Data System (ADS)

    Bazavov, A.; Bernard, C.; Bouchard, C. M.; Chang, C. C.; DeTar, C.; Du, Daping; El-Khadra, A. X.; Freeland, E. D.; Gámiz, E.; Gottlieb, Steven; Heller, U. M.; Kronfeld, A. S.; Laiho, J.; Mackenzie, P. B.; Neil, E. T.; Simone, J.; Sugar, R.; Toussaint, D.; Van de Water, R. S.; Zhou, Ran; Fermilab Lattice; MILC Collaborations

    2016-06-01

    We calculate—for the first time in three-flavor lattice QCD—the hadronic matrix elements of all five local operators that contribute to neutral B0- and Bs-meson mixing in and beyond the Standard Model. We present a complete error budget for each matrix element and also provide the full set of correlations among the matrix elements. We also present the corresponding bag parameters and their correlations, as well as specific combinations of the mixing matrix elements that enter the expression for the neutral B -meson width difference. We obtain the most precise determination to date of the SU(3)-breaking ratio ξ =1.206 (18 )(6 ), where the second error stems from the omission of charm-sea quarks, while the first encompasses all other uncertainties. The threefold reduction in total uncertainty, relative to the 2013 Flavor Lattice Averaging Group results, tightens the constraint from B mixing on the Cabibbo-Kobayashi-Maskawa (CKM) unitarity triangle. Our calculation employs gauge-field ensembles generated by the MILC Collaboration with four lattice spacings and pion masses close to the physical value. We use the asqtad-improved staggered action for the light-valence quarks and the Fermilab method for the bottom quark. We use heavy-light meson chiral perturbation theory modified to include lattice-spacing effects to extrapolate the five matrix elements to the physical point. We combine our results with experimental measurements of the neutral B -meson oscillation frequencies to determine the CKM matrix elements |Vt d|=8.00 (34 )(8 )×10-3, |Vt s|=39.0 (1.2 )(0.4 )×10-3, and |Vt d/Vt s|=0.2052 (31 )(10 ), which differ from CKM-unitarity expectations by about 2 σ . These results and others from flavor-changing-neutral currents point towards an emerging tension between weak processes that are mediated at the loop and tree levels.

  9. Matrix model for strings beyond the c =1 barrier: The spin-s Heisenberg model on random surfaces

    NASA Astrophysics Data System (ADS)

    Ambjørn, J.; Khachatryan, Sh.; Sedrakyan, A.

    2015-07-01

    We consider a spin-s Heisenberg model coupled to two-dimensional quantum gravity. We quantize the model using the Feynman path integral, summing over all possible two-dimensional geometries and spin configurations. We regularize this path integral by starting with the R-matrices defining the spin-s Heisenberg model on a regular 2d Manhattan lattice. Two-dimensional quantum gravity is included by defining the R-matrices on random Manhattan lattices and summing over these, in the same way as one sums over 2d geometries using random triangulations in noncritical string theory. We formulate a random matrix model where the partition function reproduces the annealed average of the spin-s Heisenberg model over all random Manhattan lattices. A technique is presented which reduces the random matrix integration in the partition function to an integration over their eigenvalues.

  10. Highly accelerated cardiac cine parallel MRI using low-rank matrix completion and partial separability model

    NASA Astrophysics Data System (ADS)

    Lyu, Jingyuan; Nakarmi, Ukash; Zhang, Chaoyi; Ying, Leslie

    2016-05-01

    This paper presents a new approach to highly accelerated dynamic parallel MRI using low rank matrix completion, partial separability (PS) model. In data acquisition, k-space data is moderately randomly undersampled at the center kspace navigator locations, but highly undersampled at the outer k-space for each temporal frame. In reconstruction, the navigator data is reconstructed from undersampled data using structured low-rank matrix completion. After all the unacquired navigator data is estimated, the partial separable model is used to obtain partial k-t data. Then the parallel imaging method is used to acquire the entire dynamic image series from highly undersampled data. The proposed method has shown to achieve high quality reconstructions with reduction factors up to 31, and temporal resolution of 29ms, when the conventional PS method fails.

  11. Discrete matrix models for partial sums of conformal blocks associated to Painlevé transcendents

    NASA Astrophysics Data System (ADS)

    Balogh, F.

    2015-01-01

    A recently formulated conjecture of Gamayun, Iorgov and Lisovyy gives an asymptotic expansion of the Jimbo-Miwa-Ueno isomonodromic τ-function for certain Painlevé transcendents. The coefficients in this expansion are given in terms of conformal blocks of a two-dimensional conformal field theory, which can be written as infinite sums over pairs of partitions. In this note a discrete matrix model is proposed on a lattice whose partition function can be used to obtain a multiple integral representation for the length-restricted partial sums of the Painlevé conformal blocks. This leads to expressions of the partial sums involving Hänkel determinants associated to the discrete measure of the matrix model, or equivalently, Wronskians of the corresponding moment generating function which is shown to be of the generalized hypergeometric type.

  12. Fractional supersymmetric Liouville theory and the multi-cut matrix models

    NASA Astrophysics Data System (ADS)

    Irie, Hirotaka

    2009-10-01

    We point out that the non-critical version of the k-fractional superstring theory can be described by k-cut critical points of the matrix models. In particular, in comparison with the spectrum structure of fractional super-Liouville theory, we show that (p,q) minimal fractional superstring theories appear in the Z-symmetry breaking critical points of the k-cut two-matrix models and the operator contents and string susceptibility coincide on both sides. By using this correspondence, we also propose a set of primary operators of the fractional superconformal ghost system which consistently produces the correct gravitational scaling critical exponents of the on-shell vertex operators.

  13. Floating Node Method and Virtual Crack Closure Technique for Modeling Matrix Cracking-Delamination Interaction

    NASA Technical Reports Server (NTRS)

    DeCarvalho, N. V.; Chen, B. Y.; Pinho, S. T.; Baiz, P. M.; Ratcliffe, J. G.; Tay, T. E.

    2013-01-01

    A novel approach is proposed for high-fidelity modeling of progressive damage and failure in composite materials that combines the Floating Node Method (FNM) and the Virtual Crack Closure Technique (VCCT) to represent multiple interacting failure mechanisms in a mesh-independent fashion. In this study, the approach is applied to the modeling of delamination migration in cross-ply tape laminates. Delamination, matrix cracking, and migration are all modeled using fracture mechanics based failure and migration criteria. The methodology proposed shows very good qualitative and quantitative agreement with experiments.

  14. Floating Node Method and Virtual Crack Closure Technique for Modeling Matrix Cracking-Delamination Migration

    NASA Technical Reports Server (NTRS)

    DeCarvalho, Nelson V.; Chen, B. Y.; Pinho, Silvestre T.; Baiz, P. M.; Ratcliffe, James G.; Tay, T. E.

    2013-01-01

    A novel approach is proposed for high-fidelity modeling of progressive damage and failure in composite materials that combines the Floating Node Method (FNM) and the Virtual Crack Closure Technique (VCCT) to represent multiple interacting failure mechanisms in a mesh-independent fashion. In this study, the approach is applied to the modeling of delamination migration in cross-ply tape laminates. Delamination, matrix cracking, and migration are all modeled using fracture mechanics based failure and migration criteria. The methodology proposed shows very good qualitative and quantitative agreement with experiments.

  15. Parallel Fock matrix construction with distributed shared memory model for the FMO-MO method.

    PubMed

    Umeda, Hiroaki; Inadomi, Yuichi; Watanabe, Toshio; Yagi, Toru; Ishimoto, Takayoshi; Ikegami, Tsutomu; Tadano, Hiroto; Sakurai, Tetsuya; Nagashima, Umpei

    2010-10-01

    A parallel Fock matrix construction program for FMO-MO method has been developed with the distributed shared memory model. To construct a large-sized Fock matrix during FMO-MO calculations, a distributed parallel algorithm was designed to make full use of local memory to reduce communication, and was implemented on the Global Array toolkit. A benchmark calculation for a small system indicates that the parallelization efficiency of the matrix construction portion is as high as 93% at 1,024 processors. A large FMO-MO application on the epidermal growth factor receptor (EGFR) protein (17,246 atoms and 96,234 basis functions) was also carried out at the HF/6-31G level of theory, with the frontier orbitals being extracted by a Sakurai-Sugiura eigensolver. It takes 11.3 h for the FMO calculation, 49.1 h for the Fock matrix construction, and 10 min to extract 94 eigen-components on a PC cluster system using 256 processors.

  16. Numerical Modeling of Combined Matrix Cracking and Delamination in Composite Laminates Using Cohesive Elements

    NASA Astrophysics Data System (ADS)

    Kumar, Deepak; Roy, Rene; Kweon, Jin-Hwe; Choi, Jin-ho

    2016-06-01

    Sub-laminate damage in the form of matrix cracking and delamination was simulated by using interface cohesive elements in the finite element (FE) software ABAQUS. Interface cohesive elements were inserted parallel to the fiber orientation in the transverse ply with equal spacing (matrix cracking) and between the interfaces (delamination). Matrix cracking initiation in the cohesive elements was based on stress traction separation laws and propagated under mixed-mode loading. We expanded the work of Shi et al. (Appl. Compos. Mater. 21, 57-70 2014) to include delamination and simulated additional [45/-45/0/90]s and [02/90n]s { n = 1,2,3} CFRP laminates and a [0/903]s GFRP laminate. Delamination damage was quantified numerically in terms of damage dissipative energy. We observed that transverse matrix cracks can propagate to the ply interface and initiate delamination. We also observed for [0/90n/0] laminates that as the number of 90° ply increases past n = 2, the crack density decreases. The predicted crack density evolution compared well with experimental results and the equivalent constraint model (ECM) theory. Empirical relationships were established between crack density and applied stress by linear curve fitting. The reduction of laminate elastic modulus due to cracking was also computed numerically and it is in accordance with reported experimental measurements.

  17. Evolution of the CKM matrix in the universal extra dimension model

    SciTech Connect

    Cornell, A. S.; Liu Luxin

    2011-02-01

    The evolution of the Cabibbo-Kobayashi-Maskawa matrix and the quark Yukawa couplings is performed for the one-loop renormalization group equations in the universal extra dimension model. It is found that the evolution of mixing angles and the CP violation measure J may rapidly vary in the presence of the Kaluza-Klein modes, and this variation becomes dramatic as the energy approaches the unification scale.

  18. Simplified transfer matrix approach in the two-dimensional Ising model with various boundary conditions

    NASA Astrophysics Data System (ADS)

    Kastening, Boris

    2002-11-01

    A recent simplified transfer matrix solution of the two-dimensional Ising model on a square lattice with periodic boundary conditions is generalized to periodic-antiperiodic, antiperiodic-periodic, and antiperiodic-antiperiodic boundary conditions. It is suggested to employ linear combinations of the resulting partition functions to investigate finite-size scaling. An exact relation of such a combination to the partition function corresponding to Brascamp-Kunz boundary conditions is found.

  19. Efficient methodologies for system matrix modelling in iterative image reconstruction for rotating high-resolution PET.

    PubMed

    Ortuño, J E; Kontaxakis, G; Rubio, J L; Guerra, P; Santos, A

    2010-04-07

    A fully 3D iterative image reconstruction algorithm has been developed for high-resolution PET cameras composed of pixelated scintillator crystal arrays and rotating planar detectors, based on the ordered subsets approach. The associated system matrix is precalculated with Monte Carlo methods that incorporate physical effects not included in analytical models, such as positron range effects and interaction of the incident gammas with the scintillator material. Custom Monte Carlo methodologies have been developed and optimized for modelling of system matrices for fast iterative image reconstruction adapted to specific scanner geometries, without redundant calculations. According to the methodology proposed here, only one-eighth of the voxels within two central transaxial slices need to be modelled in detail. The rest of the system matrix elements can be obtained with the aid of axial symmetries and redundancies, as well as in-plane symmetries within transaxial slices. Sparse matrix techniques for the non-zero system matrix elements are employed, allowing for fast execution of the image reconstruction process. This 3D image reconstruction scheme has been compared in terms of image quality to a 2D fast implementation of the OSEM algorithm combined with Fourier rebinning approaches. This work confirms the superiority of fully 3D OSEM in terms of spatial resolution, contrast recovery and noise reduction as compared to conventional 2D approaches based on rebinning schemes. At the same time it demonstrates that fully 3D methodologies can be efficiently applied to the image reconstruction problem for high-resolution rotational PET cameras by applying accurate pre-calculated system models and taking advantage of the system's symmetries.

  20. Noninteractive macroscopic reliability model for ceramic matrix composites with orthotropic material symmetry

    NASA Technical Reports Server (NTRS)

    Duffy, Stephen F.; Manderscheid, Jane M.

    1989-01-01

    A macroscopic noninteractive reliability model for ceramic matrix composites is presented. The model is multiaxial and applicable to composites that can be characterized as orthotropic. Tensorial invariant theory is used to create an integrity basis with invariants that correspond to physical mechanisms related to fracture. This integrity basis is then used to construct a failure function per unit volume (or area) of material. It is assumed that the overall strength of the composite is governed by weakest link theory. This leads to a Weibull type model similar in nature to the principle of independent action (PIA) model for isotropic monolithic ceramics. An experimental program to obtain model parameters is briefly discussed. In addition, qualitative features of the model are illustrated by presenting reliability surfaces for various model parameters.

  1. An improved tensile deformation model for in-situ dendrite/metallic glass matrix composites

    PubMed Central

    Sun, X. H.; Qiao, J. W.; Jiao, Z. M.; Wang, Z. H.; Yang, H. J.; Xu, B. S.

    2015-01-01

    With regard to previous tensile deformation models simulating the tensile behavior of in-situ dendrite-reinforced metallic glass matrix composites (MGMCs) [Qiao et al., Acta Mater. 59 (2011) 4126; Sci. Rep. 3 (2013) 2816], some parameters, such as yielding strength of the dendrites and glass matrix, and the strain-hardening exponent of the dendrites, are estimated based on literatures. Here, Ti48Zr18V12Cu5Be17 MGMCs are investigated in order to improve the tensile deformation model and reveal the tensile deformation mechanisms. The tensile behavior of dendrites is obtained experimentally combining nano-indentation measurements and finite-element-method analysis for the first time, and those of the glass matrix and composites are obtained by tension. Besides, the tensile behavior of the MGMCs is divided into four stages: (1) elastic-elastic, (2) elastic-plastic, (3) plastic-plastic (work-hardening), and (4) plastic-plastic (softening). The respective constitutive relationships at different deformation stages are quantified. The calculated results coincide well with the experimental results. Thus, the improved model can be applied to clarify and predict the tensile behavior of the MGMCs. PMID:26354724

  2. Fast and accurate computation of system matrix for area integral model-based algebraic reconstruction technique

    NASA Astrophysics Data System (ADS)

    Zhang, Shunli; Zhang, Dinghua; Gong, Hao; Ghasemalizadeh, Omid; Wang, Ge; Cao, Guohua

    2014-11-01

    Iterative algorithms, such as the algebraic reconstruction technique (ART), are popular for image reconstruction. For iterative reconstruction, the area integral model (AIM) is more accurate for better reconstruction quality than the line integral model (LIM). However, the computation of the system matrix for AIM is more complex and time-consuming than that for LIM. Here, we propose a fast and accurate method to compute the system matrix for AIM. First, we calculate the intersection of each boundary line of a narrow fan-beam with pixels in a recursive and efficient manner. Then, by grouping the beam-pixel intersection area into six types according to the slopes of the two boundary lines, we analytically compute the intersection area of the narrow fan-beam with the pixels in a simple algebraic fashion. Overall, experimental results show that our method is about three times faster than the Siddon algorithm and about two times faster than the distance-driven model (DDM) in computation of the system matrix. The reconstruction speed of our AIM-based ART is also faster than the LIM-based ART that uses the Siddon algorithm and DDM-based ART, for one iteration. The fast reconstruction speed of our method was accomplished without compromising the image quality.

  3. The ABCDEF's of matrix models for supersymmetric Chern-Simons theories

    NASA Astrophysics Data System (ADS)

    Gulotta, Daniel R.; Herzog, Christopher P.; Nishioka, Tatsuma

    2012-04-01

    We consider {N} = {3} supersymmetric Chern-Simons gauge theories with product unitary and orthosymplectic groups and bifundamental and fundamental fields. We study the partition functions on an S 3 by using the Kapustin-Willett-Yaakov matrix model. The saddlepoint equations in a large N limit lead to a constraint that the long range forces between the eigenvalues must cancel; the resulting quiver theories are of affine Dynkin type. We introduce a folding/unfolding trick which lets us, at the level of the large N matrix model, (i) map quivers with orthosymplectic groups to those with unitary groups, and (ii) obtain non-simply laced quivers from the corresponding simply laced quivers using a {{{Z}}_{{2}}} outer automorphism. The brane configurations of the quivers are described in string theory and the folding/unfolding is interpreted as the addition/subtraction of orientifold and orbifold planes. We also relate the U( N) quiver theories to the affine ADE quiver matrix models with a Stieltjes-Wigert type potential, and derive the generalized Seiberg duality in 2 + 1 dimensions from Seiberg duality in 3 + 1 dimensions.

  4. MATRIX-VBS Condensing Organic Aerosols in an Aerosol Microphysics Model

    NASA Technical Reports Server (NTRS)

    Gao, Chloe Y.; Tsigaridis, Konstas; Bauer, Susanne E.

    2015-01-01

    The condensation of organic aerosols is represented in a newly developed box-model scheme, where its effect on the growth and composition of particles are examined. We implemented the volatility-basis set (VBS) framework into the aerosol mixing state resolving microphysical scheme Multiconfiguration Aerosol TRacker of mIXing state (MATRIX). This new scheme is unique and advances the representation of organic aerosols in models in that, contrary to the traditional treatment of organic aerosols as non-volatile in most climate models and in the original version of MATRIX, this new scheme treats them as semi-volatile. Such treatment is important because low-volatility organics contribute significantly to the growth of particles. The new scheme includes several classes of semi-volatile organic compounds from the VBS framework that can partition among aerosol populations in MATRIX, thus representing the growth of particles via condensation of low volatility organic vapors. Results from test cases representing Mexico City and a Finish forrest condistions show good representation of the time evolutions of concentration for VBS species in the gas phase and in the condensed particulate phase. Emitted semi-volatile primary organic aerosols evaporate almost completely in the high volatile range, and they condense more efficiently in the low volatility range.

  5. Modeling of wave propagation in drill strings using vibration transfer matrix methods.

    PubMed

    Han, Je-Heon; Kim, Yong-Joe; Karkoub, Mansour

    2013-09-01

    In order to understand critical vibration of a drill bit such as stick-slip and bit-bounce and their wave propagation characteristics through a drill string system, it is critical to model the torsional, longitudinal, and flexural waves generated by the drill bit vibration. Here, a modeling method based on a vibration transfer matrix between two sets of structural wave variables at the ends of a constant cross-sectional, hollow, circular pipe is proposed. For a drill string system with multiple pipe sections, the total vibration transfer matrix is calculated by multiplying all individual matrices, each is obtained for an individual pipe section. Since drill string systems are typically extremely long, conventional numerical analysis methods such as a finite element method (FEM) require a large number of meshes, which makes it computationally inefficient to analyze these drill string systems numerically. The proposed "analytical" vibration transfer matrix method requires significantly low computational resources. For the validation of the proposed method, experimental and numerical data are obtained from laboratory experiments and FEM analyses conducted by using a commercial FEM package, ANSYS. It is shown that the modeling results obtained by using the proposed method are well matched with the experimental and numerical results.

  6. Optimal Substrate Preheating Model for Thermal Spray Deposition of Thermosets onto Polymer Matrix Composites

    NASA Technical Reports Server (NTRS)

    Ivosevic, M.; Knight, R.; Kalidindi, S. R.; Palmese, G. R.; Tsurikov, A.; Sutter, J. K.

    2003-01-01

    High velocity oxy-fuel (HVOF) sprayed, functionally graded polyimide/WC-Co composite coatings on polymer matrix composites (PMC's) are being investigated for applications in turbine engine technologies. This requires that the polyimide, used as the matrix material, be fully crosslinked during deposition in order to maximize its engineering properties. The rapid heating and cooling nature of the HVOF spray process and the high heat flux through the coating into the substrate typically do not allow sufficient time at temperature for curing of the thermoset. It was hypothesized that external substrate preheating might enhance the deposition behavior and curing reaction during the thermal spraying of polyimide thermosets. A simple analytical process model for the deposition of thermosetting polyimide onto polymer matrix composites by HVOF thermal spray technology has been developed. The model incorporates various heat transfer mechanisms and enables surface temperature profiles of the coating to be simulated, primarily as a function of substrate preheating temperature. Four cases were modeled: (i) no substrate preheating; (ii) substrates electrically preheated from the rear; (iii) substrates preheated by hot air from the front face; and (iv) substrates electrically preheated from the rear and by hot air from the front.

  7. An improved tensile deformation model for in-situ dendrite/metallic glass matrix composites.

    PubMed

    Sun, X H; Qiao, J W; Jiao, Z M; Wang, Z H; Yang, H J; Xu, B S

    2015-09-10

    With regard to previous tensile deformation models simulating the tensile behavior of in-situ dendrite-reinforced metallic glass matrix composites (MGMCs) [Qiao et al., Acta Mater. 59 (2011) 4126; Sci. Rep. 3 (2013) 2816], some parameters, such as yielding strength of the dendrites and glass matrix, and the strain-hardening exponent of the dendrites, are estimated based on literatures. Here, Ti48Zr18V12Cu5Be17 MGMCs are investigated in order to improve the tensile deformation model and reveal the tensile deformation mechanisms. The tensile behavior of dendrites is obtained experimentally combining nano-indentation measurements and finite-element-method analysis for the first time, and those of the glass matrix and composites are obtained by tension. Besides, the tensile behavior of the MGMCs is divided into four stages: (1) elastic-elastic, (2) elastic-plastic, (3) plastic-plastic (work-hardening), and (4) plastic-plastic (softening). The respective constitutive relationships at different deformation stages are quantified. The calculated results coincide well with the experimental results. Thus, the improved model can be applied to clarify and predict the tensile behavior of the MGMCs.

  8. Analytical Modeling of the High Strain Rate Deformation of Polymer Matrix Composites

    NASA Technical Reports Server (NTRS)

    Goldberg, Robert K.; Roberts, Gary D.; Gilat, Amos

    2003-01-01

    The results presented here are part of an ongoing research program to develop strain rate dependent deformation and failure models for the analysis of polymer matrix composites subject to high strain rate impact loads. State variable constitutive equations originally developed for metals have been modified in order to model the nonlinear, strain rate dependent deformation of polymeric matrix materials. To account for the effects of hydrostatic stresses, which are significant in polymers, the classical 5 plasticity theory definitions of effective stress and effective plastic strain are modified by applying variations of the Drucker-Prager yield criterion. To verify the revised formulation, the shear and tensile deformation of a representative toughened epoxy is analyzed across a wide range of strain rates (from quasi-static to high strain rates) and the results are compared to experimentally obtained values. For the analyzed polymers, both the tensile and shear stress-strain curves computed using the analytical model correlate well with values obtained through experimental tests. The polymer constitutive equations are implemented within a strength of materials based micromechanics method to predict the nonlinear, strain rate dependent deformation of polymer matrix composites. In the micromechanics, the unit cell is divided up into a number of independently analyzed slices, and laminate theory is then applied to obtain the effective deformation of the unit cell. The composite mechanics are verified by analyzing the deformation of a representative polymer matrix composite (composed using the representative polymer analyzed for the correlation of the polymer constitutive equations) for several fiber orientation angles across a variety of strain rates. The computed values compare favorably to experimentally obtained results.

  9. A matrix-calibrated species-area model for predicting biodiversity losses due to land-use change.

    PubMed

    Koh, Lian Pin; Ghazoul, Jaboury

    2010-08-01

    Application of island biogeography theory to prediction of species extinctions resulting from habitat loss is based on the assumption that the transformed landscape matrix is completely inhospitable to the taxa considered, despite evidence demonstrating the nontrivial influence of matrix on populations within habitat remnants. The island biogeography paradigm therefore needs refining to account for specific responses of taxa to the area of habitat "islands" and to the quality of the surrounding matrix. We incorporated matrix effects into island theory by partitioning the slope (z value) of species-area relationships into two components: gamma, a constant, and sigma, a measure of taxon-specific responses to each component of a heterogeneous matrix. We used our matrix-calibrated model to predict extinction and endangerment of bird species resulting from land-use change in 20 biodiversity hotspots and compared these predictions with observed numbers of extinct and threatened bird species. We repeated this analysis with the conventional species-area model and the countryside species-area model, considering alternative z values of 0.35 (island) or 0.22 (continental). We evaluated the relative strength of support for each of the five candidate models with Akaike's information criterion (AIC). The matrix-calibrated model had the highest AIC weight (w(i) = 89.21%), which means the weight of evidence in support of this model was the optimal model given the set of candidate models and the data. In addition to being a valuable heuristic tool for assessing extinction risk, our matrix-calibrated model also allows quantitative assessment of biodiversity benefits (and trade-offs) of land-management options in human-dominated landscapes. Given that processes of secondary regeneration have become more widespread across tropical regions and are predicted to increase, our matrix-calibrated model will be increasingly appropriate for practical conservation in tropical landscapes.

  10. Development of Source-Receptor matrix over South Korea in support of GAINS-Korea model

    NASA Astrophysics Data System (ADS)

    Choi, K. C.; Woo, J. H.; Kim, H. K.; Lee, Y. M.; Kim, Y.; Heyes, C.; Lee, J. B.; Song, C. K.; Han, J.

    2014-12-01

    A comprehensive and combined analysis of air pollution and climate change could reveal important synergies of emission control measures, which could be of high policy relevance. IIASA's GAINS model (The Greenhouse gas - Air pollution Interactions and Synergies) has been developed as a tool to identify emission control strategies that achieve given targets on air quality and greenhouse gas emissions at least costs. The GAINS-Korea Model, which is being jointly developed by Konkuk University and IIASA, should play an important role in understanding the impact of air quality improvements across the regions in Korea. Source-Receptor relationships (S-R) is an useful methodology in air pollution studies to determine the areas of origin of chemical compounds at receptor point, and thus be able to target actions to reduce pollutions. The GAINS model can assess the impact of emission reductions of sources on air quality in receptor regions based on S-R matrix, derived from chemical transport model. In order to develop S-R matrix for GAINS-Korea, the CAMx model with PSAT/OSAT tools was applied in this study. The coarse domain covers East Asia, and a nesting domain as main research area was used for Korea peninsula. To evaluate of S-R relationships, a modeling domain is divided into sixteen regions over South Korea with three outside of S. Korea countries (China, N. Korea and Japan) for estimating transboundary contributions. The results of our analysis will be presented at the conference.

  11. Model Predictive Control of A Matrix-Converter Based Solid State Transformer for Utility Grid Interaction

    SciTech Connect

    Xue, Yaosuo

    2016-01-01

    The matrix converter solid state transformer (MC-SST), formed from the back-to-back connection of two three-to-single-phase matrix converters, is studied for use in the interconnection of two ac grids. The matrix converter topology provides a light weight and low volume single-stage bidirectional ac-ac power conversion without the need for a dc link. Thus, the lifetime limitations of dc-bus storage capacitors are avoided. However, space vector modulation of this type of MC-SST requires to compute vectors for each of the two MCs, which must be carefully coordinated to avoid commutation failure. An additional controller is also required to control power exchange between the two ac grids. In this paper, model predictive control (MPC) is proposed for an MC-SST connecting two different ac power grids. The proposed MPC predicts the circuit variables based on the discrete model of MC-SST system and the cost function is formulated so that the optimal switch vector for the next sample period is selected, thereby generating the required grid currents for the SST. Simulation and experimental studies are carried out to demonstrate the effectiveness and simplicity of the proposed MPC for such MC-SST-based grid interfacing systems.

  12. A Note on the Asymptotic Variance-Covariance Matrix of Item Parameter Estimates in the RASCH model.

    ERIC Educational Resources Information Center

    de Gruijter, Data N. M.

    1985-01-01

    A simplification of Lord and Wingersky's method for computing the asymptotic variance-covariance matrix of maximum likelihood estimates for item and person parameters under some restrictions on the estimates is presented. Computation of the error variance-covariance matrix for the item parameters in the Rasch model is described. (NSF)

  13. Assessment of Matrix Multiplication Learning with a Rule-Based Analytical Model--"A Bayesian Network Representation"

    ERIC Educational Resources Information Center

    Zhang, Zhidong

    2016-01-01

    This study explored an alternative assessment procedure to examine learning trajectories of matrix multiplication. It took rule-based analytical and cognitive task analysis methods specifically to break down operation rules for a given matrix multiplication. Based on the analysis results, a hierarchical Bayesian network, an assessment model,…

  14. The matrix model of outpatient stimulant abuse treatment: history and description.

    PubMed

    Obert, J L; McCann, M J; Marinelli-Casey, P; Weiner, A; Minsky, S; Brethen, P; Rawson, R

    2000-01-01

    The Matrix model was originally developed in response to the cocaine epidemic of the 1980s. The program consists of relapse prevention groups, education groups, social support groups, individual counseling, and urine and breath testing delivered in a structured manner over a 16-week period. The treatment is a directive, nonconfrontational approach which focuses on current issues and behavior change. Several evaluations of the model have supported its usefulness and efficacy with methamphetamine (MA) users. Methamphetamine users appear to respond to treatment similarly to cocaine users and many continue to show improvements at follow-up.

  15. The monodromy matrix in the F-basis for arbitrary six-vertex models

    NASA Astrophysics Data System (ADS)

    Martins, M. J.; Zuparic, M.

    2011-10-01

    We present the expressions for the monodromy matrix elements of the six-vertex model in the F-basis for arbitrary Boltzmann weights. The results rely solely on the property of unitarity and Yang-Baxter relations, avoiding any specific parameterization of the weights. This allows us to write complete algebraic expressions for the inner products and the underlying domain wall partition functions in the case of arbitrary rapidities. We then apply our results for the trigonometric six-vertex model in the presence of inhomogeneous electric fields and obtain a determinant formula for the respective on-shell scalar products.

  16. A new Q-matrix in the eight-vertex model

    NASA Astrophysics Data System (ADS)

    Fabricius, Klaus

    2007-04-01

    We construct a Q-matrix for the eight-vertex model at roots of unity for crossing parameter η = 2mK/L with odd L, a case for which the existing constructions do not work. The new Q-matrix {\\skew3\\hat{Q}} depends on the spectral parameter v and also on a free parameter t. For t=0, {\\skew3\\hat{Q}} has the standard properties. For t ≠ 0, however, it does not commute with the operator S nor with itself for different values of the spectral parameter. We show that the six-vertex limit of {\\skew3\\hat{Q}}(v,t=iK^{\\prime}/2) exists.

  17. Constitutive Modeling and Testing of Polymer Matrix Composites Incorporating Physical Aging at Elevated Temperatures

    NASA Technical Reports Server (NTRS)

    Veazie, David R.

    1998-01-01

    Advanced polymer matrix composites (PMC's) are desirable for structural materials in diverse applications such as aircraft, civil infrastructure and biomedical implants because of their improved strength-to-weight and stiffness-to-weight ratios. For example, the next generation military and commercial aircraft requires applications for high strength, low weight structural components subjected to elevated temperatures. A possible disadvantage of polymer-based composites is that the physical and mechanical properties of the matrix often change significantly over time due to the exposure of elevated temperatures and environmental factors. For design, long term exposure (i.e. aging) of PMC's must be accounted for through constitutive models in order to accurately assess the effects of aging on performance, crack initiation and remaining life. One particular aspect of this aging process, physical aging, is considered in this research.

  18. Pansharpening remotely sensed data by using nonnegative matrix factorization and spectral-spatial degradation models

    NASA Astrophysics Data System (ADS)

    Farhi, Nezha; Karoui, Moussa Sofiane; Djerriri, Khelifa; Boukerch, Issam

    2016-10-01

    In this paper, a new pansharpening method, which uses nonnegative matrix factorization, is proposed to enhance the spatial resolution of remote sensing multispectral images. This method, based on the linear spectral unmixing concept and called joint spatial-spectral variables nonnegative matrix factorization, optimizes, by new iterative and multiplicative update rules, a joint-variables criterion that exploits spatial and spectral degradation models between the considered images. This criterion considers only two unknown high spatial-spectral resolutions variables. The proposed method is tested on synthetic and real datasets and its effectiveness, in spatial and spectral domains, is evaluated with established performance criteria. Results show the good performances of the proposed approach in comparison with other standard literature ones.

  19. Modeling limit languages via limit adjacency matrix and Yusof-Goode approaches

    NASA Astrophysics Data System (ADS)

    Lim, Wen Li, Yusof, Yuhani

    2015-05-01

    Limit language was introduced by Goode and Pixton in 2004 under the framework of formal language theory. It is a subset of splicing languages which is restricted to the molecules that will be presented in the splicing system after the reaction of biochemical has run to its completion. In this paper, limit adjacency matrix will be introduced to model the existence of limit languages from splicing languages. Besides, it can be used to characterize the splicing language in terms of active persistent, adult/inert and transient properties based on Yusof-Goode splicing system. In this paper, some examples and theorems that have been formulated via limit adjacency matrix approach will be presented too.

  20. Creep of Refractory Fibers and Modeling of Metal and Ceramic Matrix Composite Creep Behavior

    NASA Technical Reports Server (NTRS)

    Tewari, S.N.

    1995-01-01

    Our concentration during this research was on the following subprograms. (1) Ultra high vacuum creep tests on 218, ST300 and WHfC tungsten and MoHfC molybdenum alloy wires, temperature range from 1100 K to 1500 K, creep time of 1 to 500 hours. (2) High temperature vacuum tensile tests on 218, ST300 and WHfC tungsten and MoHfC molybdenum alloy wires. (3) Air and vacuum tensile creep tests on polycrystalline and single crystal alumina fibers, such as alumina-mullite Nextel fiber, yttrium aluminum ganet (YAG) and Saphikon, temperature range from 1150 K to 1470 K, creep time of 2 to 200 hours. (4) Microstructural evaluation of crept fibers, TEM study on the crept metal wires, SEM study on the fracture surface of ceramic fibers. (5) Metal Matrix Composite creep models, based on the fiber creep properties and fiber-matrix interface zone formation.

  1. A fiber matrix model for the filtration through fenestral pores in a compressible arterial intima.

    PubMed

    Huang, Y; Rumschitzki, D; Chien, S; Weinbaum, S

    1997-04-01

    We advance a new hypothesis to explain the changes in hydraulic conductivity of an intact artery wall with transmural pressure previously observed by Tedgui and Lever [Am. J. Physiol. 247 (Heart Circ. Physiol. 16): H784-H791, 1984] and Baldwin and Wilson [Am. J. Physiol. 264 (Heart Circ. Physiol. 33): H26-H32, 1993]. This hypothesis suggests that compaction due to pressure loading of the proteoglycan matrix in the arterial intima near fenestral pores of the internal elastic lamina (IEL) leads to a narrowing of the pore entrance area and a large decrease in local intrinsic Darcy permeability of the matrix. To quantitatively assess the feasibility of this mechanism, a local two-dimensional model is proposed to study filtration flow in the vicinity of fenestral pores in a compressible intima. Using a heterogenous fiber matrix theory, we first predict the change in Darcy permeability with intimal thickness (Li). The model then calculates local velocity profiles and pressure distributions in the intima and media. The results show a marked nonlinear steepening of intimal pressure profiles near fenestral pores when the intima thins at higher luminal pressures. The predicted relative change in resistances of the IEL (with intima, R(I)) and of the media (Rm) shows a steep increase in R(I)/Rm when Li is <20% of its unstressed value. Numerical results also suggest that intimal compression has a limiting behavior in which the much stiffer collagen fibrils inhibit further compaction at high pressures after the proteoglycan matrix is maximally compressed. Predictions are also presented to show how different transmural pressures alter growth of an intimal horseradish peroxidase spot that derives from a localized (a single cell's boundary) endothelial leakage. Such a prediction is amenable to experimental verification.

  2. Modeling of outgassing and matrix decomposition in carbon-phenolic composites

    NASA Technical Reports Server (NTRS)

    Mcmanus, Hugh L.

    1993-01-01

    A new release rate equation to model the phase change of water to steam in composite materials was derived from the theory of molecular diffusion and equilibrium moisture concentration. The new model is dependent on internal pressure, the microstructure of the voids and channels in the composite materials, and the diffusion properties of the matrix material. Hence, it is more fundamental and accurate than the empirical Arrhenius rate equation currently in use. The model was mathematically formalized and integrated into the thermostructural analysis code CHAR. Parametric studies on variation of several parameters have been done. Comparisons to Arrhenius and straight-line models show that the new model produces physically realistic results under all conditions.

  3. The Sp(3, R) Sympletic Model: a comparison of exact and approximate matrix elements

    NASA Astrophysics Data System (ADS)

    McCoy, Anna; Caprio, Mark; Rowe, David

    2014-03-01

    The Sp(3, R) symplectic model has a close physical connection to both the microscopic shell model and the collective deformation and rotational degrees of freedom, and it is a natural extension of the Elliot SU(3) model from single-shell to multi-shell dynamics. The Sp(3, R) Lie algebra--which contains the angular momentum operators, the quadrupole and vibrational momentum operators and the quadrupole flow tensor operators--is the smallest algebra containing both the shell model Hamiltonian and the rotor algebra. In the limit of large number of oscillator quanta, the Sp(3, R) algebra contracts to the U(3) boson algebra. For large values of the Casimir operator of the SU(3) subalgebra, the sp(3, R) algebra further contracts to the algebra of the collective coupled rotor-vibrator model. The exact Sp(3, R) matrix elements, calculated using the vector coherent state method, are compared with approximate matrix elements calculated in the U(3) boson limit. Science Advancement under a Cottrell Scholar Award and by the US DOE under grant DE-FG02-95ER-40934.

  4. A Micromechanical Constitutive Model of Progressive Crushing in Random Carbon Fiber Polymer Matrix Composites

    SciTech Connect

    Lee, H.K.; Simunovic, S.

    1999-09-01

    A micromechanical damage constitutive model is presented to predict the overall elastoplastic behavior and damage evolution in random carbon fiber polymer matrix composites (RFPCs).To estimate the overall elastoplastic damage responses,an effective yield criterion is derived based on the ensemble-volume averaging process and first-order effects of eigenstrains due to the existence of spheroidal (prolate) fibers.The proposed effective yield criterion,to ether with the assumed overall associative plastic flow rule and hardening law, constitutes the analytical foundation for the estimation of effective elastoplastic behavior of ductile matrix composites.First,an effective elastoplastic constitutive dama e model for aligned fiber-reinforced composites is proposed.A micromechanical damage constitutive model for RFPCs is then developed.The average process over all orientations upon overning constitutive field equations and overall yield function for aligned fiber-reinforced composites i s performed to obtain the constitutive relations and effective yield function of RFPCs.The discrete numerical integration algorithms and the continuum tan ent operator are also presented to implement the proposed dama e constitutive model.The dama e constitutive model forms the basis for the pro ressive crushing in composite structures under impact loading.

  5. Black holes as random particles: entanglement dynamics in infinite range and matrix models

    NASA Astrophysics Data System (ADS)

    Magán, Javier M.

    2016-08-01

    We first propose and study a quantum toy model of black hole dynamics. The model is unitary, displays quantum thermalization, and the Hamiltonian couples every oscillator with every other, a feature intended to emulate the color sector physics of large- {N} matrix models. Considering out of equilibrium initial states, we analytically compute the time evolution of every correlator of the theory and of the entanglement entropies, allowing a proper discussion of global thermalization/scrambling of information through the entire system. Microscopic non-locality causes factorization of reduced density matrices, and entanglement just depends on the time evolution of occupation densities. In the second part of the article, we show how the gained intuition extends to large- {N} matrix models, where we provide a gauge invariant entanglement entropy for `generalized free fields', again depending solely on the quasinormal frequencies. The results challenge the fast scrambling conjecture and point to a natural scenario for the emergence of the so-called brick wall or stretched horizon. Finally, peculiarities of these models in regards to the thermodynamic limit and the information paradox are highlighted.

  6. A dynamic model of mobile concrete pump boom based on discrete time transfer matrix method

    NASA Astrophysics Data System (ADS)

    Ren, Wu; Wu, Yunxin; Zhang, Zhaowei

    2013-12-01

    Mobile concrete pump boom is typical multibody large-scale motion manipulator. Due to posture constantly change in working process, kinematic rule and dynamic characteristic are difficult to solve. A dynamics model of a mobile concrete pump boom is established based on discrete time transfer matrix method (DTTMM). The boom system is divided into sub-structure A and substructure B. Sub-structure A is composed by the 1st boom and hydraulic actuator as well as the support. And substructure B is consists of the other three booms and corresponding hydraulic actuators. In the model, the booms and links are regarded as rigid elements and the hydraulic cylinders are equivalent to spring-damper. The booms are driven by the controllable hydraulic actuators. The overall dynamic equation and transfer matrix of the model can be assembled by sub-structures A and B. To get a precise result, step size and integration parameters are studied then. Next the tip displacement is calculated and compared with the result of ADAMS software. The displacement and rotation angle curves of the proposed method fit well with the ADAMS model. Besides it is convenient in modeling and saves time. So it is suitable for mobile concrete pump boom real-time monitoring and dynamic analysis. All of these provide reference to boom optimize and engineering application of such mechanisms.

  7. Modeling the Effect of Interface Wear on Fatigue Hysteresis Behavior of Carbon Fiber-Reinforced Ceramic-Matrix Composites

    NASA Astrophysics Data System (ADS)

    Longbiao, Li

    2015-12-01

    An analytical method has been developed to investigate the effect of interface wear on fatigue hysteresis behavior in carbon fiber-reinforced ceramic-matrix composites (CMCs). The damage mechanisms, i.e., matrix multicracking, fiber/matrix interface debonding and interface wear, fibers fracture, slip and pull-out, have been considered. The statistical matrix multicracking model and fracture mechanics interface debonding criterion were used to determine the matrix crack spacing and interface debonded length. Upon first loading to fatigue peak stress and subsequent cyclic loading, the fibers failure probabilities and fracture locations were determined by combining the interface wear model and fiber statistical failure model based on the assumption that the loads carried by broken and intact fibers satisfy the global load sharing criterion. The effects of matrix properties, i.e., matrix cracking characteristic strength and matrix Weibull modulus, interface properties, i.e., interface shear stress and interface debonded energy, fiber properties, i.e., fiber Weibull modulus and fiber characteristic strength, and cycle number on fibers failure, hysteresis loops and interface slip, have been investigated. The hysteresis loops under fatigue loading from the present analytical method were in good agreement with experimental data.

  8. $B^0_{(s)}$-mixing matrix elements from lattice QCD for the Standard Model and beyond

    SciTech Connect

    Bazavov, A.; Bernard, C.; Bouchard, C. M.; Chang, C. C.; DeTar, C.; Du, Daping; El-Khadra, A. X.; Freeland, E. D.; Gamiz, E.; Gottlieb, Steven; Heller, U. M.; Kronfeld, A. S.; Laiho, J.; Mackenzie, P. B.; Neil, E. T.; Simone, J.; Sugar, R.; Toussaint, D.; Van de Water, R. S.; Zhou, Ran

    2016-06-28

    We calculate—for the first time in three-flavor lattice QCD—the hadronic matrix elements of all five local operators that contribute to neutral B0- and Bs-meson mixing in and beyond the Standard Model. We present a complete error budget for each matrix element and also provide the full set of correlations among the matrix elements. We also present the corresponding bag parameters and their correlations, as well as specific combinations of the mixing matrix elements that enter the expression for the neutral B-meson width difference. We obtain the most precise determination to date of the SU(3)-breaking ratio ξ=1.206(18)(6), where the second error stems from the omission of charm-sea quarks, while the first encompasses all other uncertainties. The threefold reduction in total uncertainty, relative to the 2013 Flavor Lattice Averaging Group results, tightens the constraint from B mixing on the Cabibbo-Kobayashi-Maskawa (CKM) unitarity triangle. Our calculation employs gauge-field ensembles generated by the MILC Collaboration with four lattice spacings and pion masses close to the physical value. We use the asqtad-improved staggered action for the light-valence quarks and the Fermilab method for the bottom quark. We use heavy-light meson chiral perturbation theory modified to include lattice-spacing effects to extrapolate the five matrix elements to the physical point. We combine our results with experimental measurements of the neutral B-meson oscillation frequencies to determine the CKM matrix elements |Vtd| = 8.00(34)(8)×10-3, |Vts| = 39.0(1.2)(0.4)×10-3, and |Vtd/Vts| = 0.2052(31)(10), which differ from CKM-unitarity expectations by about 2σ. In addition, these results and others from flavor-changing-neutral currents point towards an emerging tension between weak processes that are mediated at the loop and tree levels.

  9. $$B^0_{(s)}$$-mixing matrix elements from lattice QCD for the Standard Model and beyond

    DOE PAGES

    Bazavov, A.; Bernard, C.; Bouchard, C. M.; ...

    2016-06-28

    We calculate—for the first time in three-flavor lattice QCD—the hadronic matrix elements of all five local operators that contribute to neutral B0- and Bs-meson mixing in and beyond the Standard Model. We present a complete error budget for each matrix element and also provide the full set of correlations among the matrix elements. We also present the corresponding bag parameters and their correlations, as well as specific combinations of the mixing matrix elements that enter the expression for the neutral B-meson width difference. We obtain the most precise determination to date of the SU(3)-breaking ratio ξ=1.206(18)(6), where the second errormore » stems from the omission of charm-sea quarks, while the first encompasses all other uncertainties. The threefold reduction in total uncertainty, relative to the 2013 Flavor Lattice Averaging Group results, tightens the constraint from B mixing on the Cabibbo-Kobayashi-Maskawa (CKM) unitarity triangle. Our calculation employs gauge-field ensembles generated by the MILC Collaboration with four lattice spacings and pion masses close to the physical value. We use the asqtad-improved staggered action for the light-valence quarks and the Fermilab method for the bottom quark. We use heavy-light meson chiral perturbation theory modified to include lattice-spacing effects to extrapolate the five matrix elements to the physical point. We combine our results with experimental measurements of the neutral B-meson oscillation frequencies to determine the CKM matrix elements |Vtd| = 8.00(34)(8)×10-3, |Vts| = 39.0(1.2)(0.4)×10-3, and |Vtd/Vts| = 0.2052(31)(10), which differ from CKM-unitarity expectations by about 2σ. In addition, these results and others from flavor-changing-neutral currents point towards an emerging tension between weak processes that are mediated at the loop and tree levels.« less

  10. Evaluation of Solid Modeling Software for Finite Element Analysis of Woven Ceramic Matrix Composites

    NASA Technical Reports Server (NTRS)

    Nemeth, Noel N.; Mital, Subodh; Lang, Jerry

    2010-01-01

    Three computer programs, used for the purpose of generating 3-D finite element models of the Repeating Unit Cell (RUC) of a textile, were examined for suitability to model woven Ceramic Matrix Composites (CMCs). The programs evaluated were the open-source available TexGen, the commercially available WiseTex, and the proprietary Composite Material Evaluator (COMATE). A five-harness-satin (5HS) weave for a melt-infiltrated (MI) silicon carbide matrix and silicon carbide fiber was selected as an example problem and the programs were tested for their ability to generate a finite element model of the RUC. The programs were also evaluated for ease-of-use and capability, particularly for the capability to introduce various defect types such as porosity, ply shifting, and nesting of a laminate. Overall, it was found that TexGen and WiseTex were useful for generating solid models of the tow geometry; however, there was a lack of consistency in generating well-conditioned finite element meshes of the tows and matrix. TexGen and WiseTex were both capable of allowing collective and individual shifting of tows within a ply and WiseTex also had a ply nesting capability. TexGen and WiseTex were sufficiently userfriendly and both included a Graphical User Interface (GUI). COMATE was satisfactory in generating a 5HS finite element mesh of an idealized weave geometry but COMATE lacked a GUI and was limited to only 5HS and 8HS weaves compared to the larger amount of weave selections available with TexGen and WiseTex.

  11. Nonlinearity and Strain-Rate Dependence in the Deformation Response of Polymer Matrix Composites Modeled

    NASA Technical Reports Server (NTRS)

    Goldberg, Robert K.

    2000-01-01

    There has been no accurate procedure for modeling the high-speed impact of composite materials, but such an analytical capability will be required in designing reliable lightweight engine-containment systems. The majority of the models in use assume a linear elastic material response that does not vary with strain rate. However, for containment systems, polymer matrix composites incorporating ductile polymers are likely to be used. For such a material, the deformation response is likely to be nonlinear and to vary with strain rate. An analytical model has been developed at the NASA Glenn Research Center at Lewis Field that incorporates both of these features. A set of constitutive equations that was originally developed to analyze the viscoplastic deformation of metals (Ramaswamy-Stouffer equations) was modified to simulate the nonlinear, rate-dependent deformation of polymers. Specifically, the effects of hydrostatic stresses on the inelastic response, which can be significant in polymers, were accounted for by a modification of the definition of the effective stress. The constitutive equations were then incorporated into a composite micromechanics model based on the mechanics of materials theory. This theory predicts the deformation response of a composite material from the properties and behavior of the individual constituents. In this manner, the nonlinear, rate-dependent deformation response of a polymer matrix composite can be predicted.

  12. A semi-analytical method for simulating matrix diffusion in numerical transport models

    NASA Astrophysics Data System (ADS)

    Falta, Ronald W.; Wang, Wenwen

    2017-02-01

    A semi-analytical approximation for transient matrix diffusion is developed for use in numerical contaminant transport simulators. This method is an adaptation and extension of the heat conduction method of Vinsome and Westerveld (1980) used to simulate heat losses during thermally enhanced oil recovery. The semi-analytical method is used in place of discretization of the low permeability materials, and it represents the concentration profile in the low permeability materials with a fitting function that is adjusted in each element at each time-step. The resulting matrix diffusion fluxes are added to the numerical model as linear concentration-dependent source/sink terms. Since only the high permeability zones need to be discretized, the numerical formulation is extremely efficient compared to traditional approaches that require discretization of both the high and low permeability zones. The semi-analytical method compares favorably with the analytical solution for transient one-dimensional diffusion with first order decay, with a two-layer aquifer/aquitard solution, with the solution for transport in a fracture with matrix diffusion and decay, and with a fully numerical solution for transport in a thin sand zone bounded by clay with variable decay rates.

  13. A semi-analytical method for simulating matrix diffusion in numerical transport models.

    PubMed

    Falta, Ronald W; Wang, Wenwen

    2017-02-01

    A semi-analytical approximation for transient matrix diffusion is developed for use in numerical contaminant transport simulators. This method is an adaptation and extension of the heat conduction method of Vinsome and Westerveld (1980) used to simulate heat losses during thermally enhanced oil recovery. The semi-analytical method is used in place of discretization of the low permeability materials, and it represents the concentration profile in the low permeability materials with a fitting function that is adjusted in each element at each time-step. The resulting matrix diffusion fluxes are added to the numerical model as linear concentration-dependent source/sink terms. Since only the high permeability zones need to be discretized, the numerical formulation is extremely efficient compared to traditional approaches that require discretization of both the high and low permeability zones. The semi-analytical method compares favorably with the analytical solution for transient one-dimensional diffusion with first order decay, with a two-layer aquifer/aquitard solution, with the solution for transport in a fracture with matrix diffusion and decay, and with a fully numerical solution for transport in a thin sand zone bounded by clay with variable decay rates.

  14. Spin Matrix theory: a quantum mechanical model of the AdS/CFT correspondence

    NASA Astrophysics Data System (ADS)

    Harmark, Troels; Orselli, Marta

    2014-11-01

    We introduce a new quantum mechanical theory called Spin Matrix theory (SMT). The theory is interacting with a single coupling constant g and is based on a Hilbert space of harmonic oscillators with a spin index taking values in a Lie (super)algebra representation as well as matrix indices for the adjoint representation of U( N). We show that SMT describes super-Yang-Mills theory (SYM) near zero-temperature critical points in the grand canonical phase diagram. Equivalently, SMT arises from non-relativistic limits of SYM. Even though SMT is a non-relativistic quantum mechanical theory it contains a variety of phases mimicking the AdS/CFT correspondence. Moreover, the g → ∞ limit of SMT can be mapped to the supersymmetric sector of string theory on AdS5 × S 5. We study SU(2) SMT in detail. At large N and low temperatures it is a theory of spin chains that for small g resembles planar gauge theory and for large g a non-relativistic string theory. When raising the temperature a partial deconfinement transition occurs due to finite- N effects. For sufficiently high temperatures the partially deconfined phase has a classical regime. We find a matrix model description of this regime at any coupling g. Setting g = 0 it is a theory of N 2 + 1 harmonic oscillators while for large g it becomes 2 N harmonic oscillators.

  15. Phase space and phase transitions in the Penner matrix model with negative coupling constant

    NASA Astrophysics Data System (ADS)

    Álvarez, Gabriel; Martínez Alonso, Luis; Medina, Elena

    2017-03-01

    The partition function of the Penner matrix model for both positive and negative values of the coupling constant can be explicitly written in terms of the Barnes G function. In this paper we show that for negative values of the coupling constant this partition function can also be represented as the product of an holomorphic matrix integral by a nontrivial oscillatory function of n. We show that the planar limit of the free energy with ’t Hooft sequences does not exist. Therefore we use a certain modification that uses Kuijlaars–McLaughlin sequences instead of ’t Hooft sequences and leads to a well-defined planar free energy and to an associated two-dimensional phase space. We describe the different configurations of complex saddle points of the holomorphic matrix integral both to the left and to the right of the critical point, and interpret the phase transitions in terms of processes of gap closing, eigenvalue tunneling, and Bose condensation.

  16. Application of Transfer Matrix Approach to Modeling and Decentralized Control of Lattice-Based Structures

    NASA Technical Reports Server (NTRS)

    Cramer, Nick; Swei, Sean Shan-Min; Cheung, Kenny; Teodorescu, Mircea

    2015-01-01

    This paper presents a modeling and control of aerostructure developed by lattice-based cellular materials/components. The proposed aerostructure concept leverages a building block strategy for lattice-based components which provide great adaptability to varying ight scenarios, the needs of which are essential for in- ight wing shaping control. A decentralized structural control design is proposed that utilizes discrete-time lumped mass transfer matrix method (DT-LM-TMM). The objective is to develop an e ective reduced order model through DT-LM-TMM that can be used to design a decentralized controller for the structural control of a wing. The proposed approach developed in this paper shows that, as far as the performance of overall structural system is concerned, the reduced order model can be as e ective as the full order model in designing an optimal stabilizing controller.

  17. Separation of variables in anisotropic models and non-skew-symmetric elliptic r-matrix

    NASA Astrophysics Data System (ADS)

    Skrypnyk, Taras

    2016-11-01

    We solve a problem of separation of variables for the classical integrable hamiltonian systems possessing Lax matrices satisfying linear Poisson brackets with the non-skew-symmetric, non-dynamical elliptic so(3)⊗ so(3) -valued classical r-matrix. Using the corresponding Lax matrices, we present a general form of the "separating functions" B(u) and A(u) that generate the coordinates and the momenta of separation for the associated models. We consider several examples and perform the separation of variables for the classical anisotropic Euler's top, Steklov-Lyapunov model of the motion of anisotropic rigid body in the liquid, two-spin generalized Gaudin model and "spin" generalization of Steklov-Lyapunov model.

  18. EFFECT OF MODEL-DEPENDENT COVARIANCE MATRIX FOR STUDYING BARYON ACOUSTIC OSCILLATIONS

    SciTech Connect

    Labatie, A.; Starck, J. L.

    2012-12-01

    Large-scale structures in the universe are a powerful tool to test cosmological models and constrain cosmological parameters. A particular feature of interest comes from baryon acoustic oscillations (BAOs), which are sound waves traveling in the hot plasma of the early universe that stopped at the recombination time. This feature can be observed as a localized bump in the correlation function at the scale of the sound horizon r{sub s} . As such, it provides a standard ruler and a lot of constraining power in the correlation function analysis of galaxy surveys. Moreover, the detection of BAOs at the expected scale gives strong support to cosmological models. Both of these studies (BAO detection and parameter constraints) rely on a statistical modeling of the measured correlation function {xi}-circumflex. Usually {xi}-circumflex is assumed to be Gaussian, with a mean {xi}{sub {theta}} depending on the cosmological model and a covariance matrix C generally approximated as a constant (i.e., independent of the model). In this article, we study whether a realistic model-dependent C {sub {theta}} changes the results of cosmological parameter constraints compared to the approximation of a constant covariance matrix C. For this purpose, we use a new procedure to generate lognormal realizations of the luminous red galaxy sample of the Sloan Digital Sky Survey Data Release 7 to obtain a model-dependent C {sub {theta}} in a reasonable time. The approximation of C {sub {theta}} as a constant creates small changes in the cosmological parameter constraints on our sample. We quantify this modeling error using a lot of simulations and find that it only has a marginal influence on cosmological parameter constraints for current and next-generation galaxy surveys. It can be approximately taken into account by extending the 1{sigma} intervals by a factor Almost-Equal-To 1.3.

  19. A mathematical model of the inline CMOS matrix sensor for investigation of particles in hydraulic liquids

    NASA Astrophysics Data System (ADS)

    Kornilin, DV; Kudryavtsev, IA

    2016-10-01

    One of the most effective ways to diagnose the state of hydraulic system is an investigation of the particles in their liquids. The sizes of such particles range from 2 to 200 gm and their concentration and shape reveal important information about the current state of equipment and the necessity of maintenance. In-line automatic particle counters (APC), which are built into hydraulic system, are widely used for determination of particle size and concentration. These counters are based on a single photodiode and a light emitting diode (LED); however, samples of liquid are needed for analysis using microscope or industrial video camera in order to get information about particle shapes. The act of obtaining the sample leads to contamination by other particles from the air or from the sample tube, meaning that the results are usually corrupted. Using the CMOS or CCD matrix sensor without any lens for inline APC is the solution proposed by authors. In this case the matrix sensors are put into the liquid channel of the hydraulic system and illuminated by LED. This system could be stable in arduous conditions like high pressure and the vibration of the hydraulic system; however, the image or signal from that matrix sensor needs to be processed differently in comparison with the signal from microscope or industrial video camera because of relatively short distance between LED and sensor. This paper introduces mathematical model of a sensor with CMOS and LED, which can be built into hydraulic system. It is also provided a computational algorithm and results, which can be useful for calculation of particle sizes and shapes using the signal from the CMOS matrix sensor.

  20. A Bridging Cell Multiscale Methodology to Model the Structural Behaviour of Polymer Matrix Composites

    NASA Astrophysics Data System (ADS)

    Iacobellis, Vincent

    Composite and nanocomposite materials exhibit behaviour which is inherently multiscale, extending from the atomistic to continuum levels. In composites, damage growth tends to occur at the nano and microstructural scale by means of crack growth and fibre-matrix debonding. Concurrent multiscale modeling provides a means of efficiently solving such localized phenomena, however its use in this application has been limited due to a number of existing issues in the multiscale field. These include the seamless transfer of information between continuum and atomistic domains, the small timesteps required for dynamic simulation, and limited research into concurrent multiscale modeling of amorphous polymeric materials. The objective of this thesis is thus twofold: to formulate a generalized approach to solving a coupled atomistic-to-continuum system that addresses these issues and to extend the application space of concurrent multiscale modeling to damage modeling in composite microstructures. To achieve these objectives, a finite element based multiscale technique termed the Bridging Cell Method (BCM), has been formulated with a focus on crystalline material systems. Case studies are then presented that show the effectiveness of the developed technique with respect to full atomistic simulations. The BCM is also demonstrated for applications of stress around a nanovoid, nanoindentation, and crack growth due to monotonic and cyclic loading. Next, the BCM is extended to modeling amorphous polymeric material systems where an adaptive solver and a two-step iterative solution algorithm are introduced. Finally, the amorphous and crystalline BCM is applied to modeling a polymer-graphite interface. This interface model is used to obtain cohesive zone parameters which are used in a cohesive zone model of fibre-matrix interfacial cracking in a composite microstructure. This allows for an investigation of the temperature dependent damage mechanics from the nano to microscale within

  1. A Chemomechanical Model of Matrix and Nuclear Rigidity Regulation of Focal Adhesion Size

    PubMed Central

    Cao, Xuan; Lin, Yuan; Driscoll, Tristian P.; Franco-Barraza, Janusz; Cukierman, Edna; Mauck, Robert L.; Shenoy, Vivek B.

    2015-01-01

    In this work, a chemomechanical model describing the growth dynamics of cell-matrix adhesion structures (i.e., focal adhesions (FAs)) is developed. We show that there are three regimes for FA evolution depending on their size. Specifically, nascent adhesions with initial lengths below a critical value that are yet to engage in actin fibers will dissolve, whereas bigger ones will grow into mature FAs with a steady state size. In adhesions where growth surpasses the steady state size, disassembly will occur until their sizes are reduced to the equilibrium state. This finding arises from the fact that polymerization of adhesion proteins is force-dependent. Under actomyosin contraction, individual integrin bonds within small FAs (i.e., nascent adhesions or focal complexes) must transmit higher loads while the phenomenon of stress concentration occurs at the edge of large adhesion patches. As such, an effective stiffness of the FA-extracellular matrix complex that is either too small or too large will be relatively low, resulting in a limited actomyosin pulling force developed at the edge that is insufficient to prevent disassembly. Furthermore, it is found that a stiffer extracellular matrix and/or nucleus, as well as a stronger chemomechanical feedback, will induce larger adhesions along with a higher level of contraction force. Interestingly, switching the extracellular side from an elastic half-space, corresponding to some widely used in vitro gel substrates, to a one-dimensional fiber (as in the case of cells anchoring to a fibrous scaffold in vivo) does not qualitative change these conclusions. Our model predictions are in good agreement with a variety of experimental observations obtained in this study as well as those reported in the literature. Furthermore, this new model, to our knowledge, provides a framework with which to understand how both intracellular and extracellular perturbations lead to changes in adhesion structure number and size. PMID:26536258

  2. Gap formation and phase transition of the anisotropic Kondo necklace model: Density matrix renormalization group analysis

    NASA Astrophysics Data System (ADS)

    Mendoza-Arenas, J. J.; Franco, R.; Silva-Valencia, J.

    2010-01-01

    We analyze the one-dimensional Kondo necklace model, at zero temperature, with an anisotropy parameter η in the interaction of the conduction chain, by means of the density matrix renormalization group. We calculate the energy gap and estimate the quantum critical points that separate a Kondo singlet state from an antiferromagnetic state, assuming a Kosterlitz-Thouless tendency. We also observe the correlation functions and the structure factors that support our critical points. The resulting phase diagram is presented and compared to that reported previously using Lanczos calculations. It is shown that the quantum critical points vary very slowly with η , but when η approaches zero, they drop abruptly.

  3. Matrix Models and Eigenvalue Statistics for Truncations of Classical Ensembles of Random Unitary Matrices

    NASA Astrophysics Data System (ADS)

    Killip, Rowan; Kozhan, Rostyslav

    2017-02-01

    We consider random non-normal matrices constructed by removing one row and column from samples from Dyson's circular ensembles or samples from the classical compact groups. We develop sparse matrix models whose spectral measures match these ensembles. This allows us to compute the joint law of the eigenvalues, which have a natural interpretation as resonances for open quantum systems or as electrostatic charges located in a dielectric medium. Our methods allow us to consider all values of {β > 0}, not merely {β=1,2,4}.

  4. Complex saddle points in the Gross-Witten-Wadia matrix model

    NASA Astrophysics Data System (ADS)

    Álvarez, Gabriel; Alonso, Luis Martínez; Medina, Elena

    2016-11-01

    We give an exhaustive characterization of the complex saddle point configurations of the Gross-Witten-Wadia matrix model in the large-N limit. In particular, we characterize the cases in which the saddles accumulate in one, two, or three arcs, in terms of the values of the coupling constant and of the fraction of the total unit density that is supported in one of the arcs, and derive an explicit condition for gap closing associated with nonvacuum saddles. By applying the idea of large-N instanton we also give direct analytic derivations of the weak-coupling and strong-coupling instanton actions.

  5. R-matrix and Potential Model Extrapolations for NACRE Update and Extension Project

    SciTech Connect

    Aikawa, Masayuki; Katsuma, Masahiko; Takahashi, Kohji; Arnould, Marcel; Arai, Koji; Utsunomiya, Hiroaki

    2006-07-12

    NACRE, the 'nuclear astrophysics compilation of reaction rates', has been widely utilized in stellar evolution and nucleosynthesis studies. Its update and extension programme started within a Konan-Universite Libre de Bruxelles (ULB) collaboration. At the present moment, experimental data in refereed journals have been collected, and their theoretical extrapolations are being performed using the R-matrix or potential models. For the 3H(d,n)4He and 2H(p,{gamma})3He reactions, we present preliminary results that could well reproduce the experimental data.

  6. Density Induced Phase Transitions in the Schwinger Model: A Study with Matrix Product States

    NASA Astrophysics Data System (ADS)

    Bañuls, Mari Carmen; Cichy, Krzysztof; Cirac, J. Ignacio; Jansen, Karl; Kühn, Stefan

    2017-02-01

    We numerically study the zero temperature phase structure of the multiflavor Schwinger model at nonzero chemical potential. Using matrix product states, we reproduce analytical results for the phase structure for two flavors in the massless case and extend the computation to the massive case, where no analytical predictions are available. Our calculations allow us to locate phase transitions in the mass-chemical potential plane with great precision and provide a concrete example of tensor networks overcoming the sign problem in a lattice gauge theory calculation.

  7. Periodic matrix population models: growth rate, basic reproduction number, and entropy.

    PubMed

    Bacaër, Nicolas

    2009-10-01

    This article considers three different aspects of periodic matrix population models. First, a formula for the sensitivity analysis of the growth rate lambda is obtained that is simpler than the one obtained by Caswell and Trevisan. Secondly, the formula for the basic reproduction number R0 in a constant environment is generalized to the case of a periodic environment. Some inequalities between lambda and R0 proved by Cushing and Zhou are also generalized to the periodic case. Finally, we add some remarks on Demetrius' notion of evolutionary entropy H and its relationship to the growth rate lambda in the periodic case.

  8. Probing the smearing effect by a pointlike graviton in the plane-wave matrix model

    SciTech Connect

    Lee, Bum-Hoon; Nam, Siyoung; Shin, Hyeonjoon

    2010-08-15

    We investigate the interaction between a flat membrane and pointlike graviton in the plane-wave matrix model. The one-loop effective potential in the large-distance limit is computed and is shown to be of r{sup -3} type where r is the distance between two objects. This type of interaction has been interpreted as the one incorporating the smearing effect due to the configuration of a flat membrane in a plane-wave background. Our results support this interpretation and provide more evidence about it.

  9. Matrix Pseudospectral Method for (Visco)Elastic Tides Modeling of Planetary Bodies

    NASA Astrophysics Data System (ADS)

    Zabranova, Eliska; Hanyk, Ladidslav; Matyska, Ctirad

    2010-05-01

    We deal with the equations and boundary conditions describing deformation and gravitational potential of prestressed spherically symmetric elastic bodies by decomposing governing equations into a series of boundary value problems (BVP) for ordinary differential equations (ODE) of the second order. In contrast to traditional Runge-Kutta integration techniques, highly accurate pseudospectral schemes are employed to directly discretize the BVP on Chebyshev grids and a set of linear algebraic equations with an almost block diagonal matrix is derived. As a consequence of keeping the governing ODEs of the second order instead of the usual first-order equations, the resulting algebraic system is half-sized but derivatives of the model parameters are required. Moreover, they can be easily evaluated for models, where structural parametres are piecewise polynomially dependent. Both accuracy and efficiency of the method are tested by evaluating the tidal Love numbers for the Earth's model PREM. Finally, we also derive complex Love numbers for models with the Maxwell viscoelastic rheology, where viscosity is a depth-dependent function. The method is applied to evaluation of the tidal Love numbers for models of Mars and Venus. The Love numbers of the two Martian models - the former optimized to cosmochemical data and the latter to the moment of inertia (Sohl and Spohn, 1997) - are h2=0.172 (0.212) and k2=0.093 (0.113). For Venus, the value of k2=0.295 (Konopliv and Yoder, 1996), obtained from the gravity-field analysis, is consistent with the results for our model with the liquid-core radius of 3110 km (Zábranová et al., 2009). Together with rapid evaluation of free oscillation periods by an analogous method, this combined matrix approach could by employed as an efficient numerical tool in structural studies of planetary bodies. REFERENCES Konopliv, A. S. and Yoder, C. F., 1996. Venusian k2 tidal Love number from Magellan and PVO tracking data, Geophys. Res. Lett., 23, 1857

  10. Micromechanics Fatigue Damage Analysis Modeling for Fabric Reinforced Ceramic Matrix Composites

    NASA Technical Reports Server (NTRS)

    Min, J. B.; Xue, D.; Shi, Y.

    2013-01-01

    A micromechanics analysis modeling method was developed to analyze the damage progression and fatigue failure of fabric reinforced composite structures, especially for the brittle ceramic matrix material composites. A repeating unit cell concept of fabric reinforced composites was used to represent the global composite structure. The thermal and mechanical properties of the repeating unit cell were considered as the same as those of the global composite structure. The three-phase micromechanics, the shear-lag, and the continuum fracture mechanics models were integrated with a statistical model in the repeating unit cell to predict the progressive damages and fatigue life of the composite structures. The global structure failure was defined as the loss of loading capability of the repeating unit cell, which depends on the stiffness reduction due to material slice failures and nonlinear material properties in the repeating unit cell. The present methodology is demonstrated with the analysis results evaluated through the experimental test performed with carbon fiber reinforced silicon carbide matrix plain weave composite specimens.

  11. A Tensile Deformation Model for In-situ Dendrite/Metallic Glass Matrix Composites

    PubMed Central

    Qiao, J. W.; Zhang, T.; Yang, F. Q.; Liaw, P. K.; Pauly, S.; Xu, B. S.

    2013-01-01

    In-situ dendrite/metallic glass matrix composites (MGMCs) with a composition of Ti46Zr20V12Cu5Be17 exhibit ultimate tensile strength of 1510 MPa and fracture strain of about 7.6%. A tensile deformation model is established, based on the five-stage classification: (1) elastic-elastic, (2) elastic-plastic, (3) plastic-plastic (yield platform), (4) plastic-plastic (work hardening), and (5) plastic-plastic (softening) stages, analogous to the tensile behavior of common carbon steels. The constitutive relations strongly elucidate the tensile deformation mechanism. In parallel, the simulation results by a finite-element method (FEM) are in good agreement with the experimental findings and theoretical calculations. The present study gives a mathematical model to clarify the work-hardening behavior of dendrites and softening of the amorphous matrix. Furthermore, the model can be employed to simulate the tensile behavior of in-situ dendrite/MGMCs. PMID:24085187

  12. Modelling matrix diffusion in high-pH infiltration tests in concrete columns

    NASA Astrophysics Data System (ADS)

    Carme Chaparro, M.; Saaltink, Maarten W.; Soler, Josep M.; Slooten, Luit Jan; Mäder, Urs

    2014-05-01

    Tracer tests in concrete columns have been carried out to improve the characterization of the transport properties of the concrete from the Radioactive Waste Disposal Facility at El Cabril (Spain). High entry pressure has been employed in order to perform the experiments in a reasonable time span. Three tests have been performed using different infiltration solutions, with pH 12.6, 7.0 and 13.4, respectively. Lithium, bromide and deuterium have been used as tracers. Experimental results show that permeability decreases with time probably because of mineral precipitation. So, solute transport in concrete cannot easily be decoupled from reactions. A preliminary model of only advection and dispersion could not be fitted satisfactory to the breakthrough curves of conservative tracers. Therefore, we added matrix diffusion between a mobile pore domain, where water can flow, and an immobile zone without any advective flow. Three conceptual models have been compared, considering the immobile zone as (i) slabs, (ii) spheres and (iii) tubes. Porosity of the mobile and immobile zones, size of the immobile zone and a diffusion coefficient are estimated by calibrating the model results to the measured breakthrough curve. The calculated values show that matrix diffusion plays an important role in solute transport. The best fit is obtained with the tube concept: cylindrical diffusion from concrete (large radius) to mobile zone (small radius).

  13. A Computational Model of In Vitro Angiogenesis based on Extracellular Matrix Fiber Orientation

    PubMed Central

    Edgar, Lowell T.; Sibole, Scott C.; Underwood, Clayton J.; Guilkey, James E.; Weiss, Jeffrey A.

    2012-01-01

    Recent interest in the process of vascularization within the biomedical community has motivated numerous new research efforts focusing on the process of angiogenesis. Although the role of chemical factors during angiogenesis has been well documented, the role of mechanical factors, such as the interaction between angiogenic vessels and the extracellular matrix, remain poorly understood. In vitro methods for studying angiogenesis exist, however measurements available using such techniques often suffer from limited spatial and temporal resolution. For this reason, computational models have been extensively employed to investigate various aspects of angiogenesis. This manuscript outlines the formulation and validation of a simple and robust computational model developed to accurately simulate angiogenesis based on length, branching, and orientation morphometrics collected from vascularized tissue constructs. Excellent agreement was observed between computational and experimental morphometric data over time. Computational predictions of microvessel orientation within an anisotropic matrix correlated well with experimental data. The accuracy of this modeling approach makes it a valuable platform for investigating the role of mechanical interactions during angiogenesis. PMID:22515707

  14. Dynamic densification of metal matrix-coated fibre composites: modelling and processing

    SciTech Connect

    Peng, H.X.; Dunne, F.P.E. . E-mail: fionn.dunne@eng.ox.ac.uk; Grant, P.S.; Cantor, B.

    2005-02-01

    The consolidation processing of Ti-6Al-4V matrix-coated fibre (MCF) composite under vacuum hot pressing (VHP) has been investigated. A new test methodology has been developed for the determination of in situ matrix coating creep properties. In using the methodology, only a single, simple test is required, together with finite element modelling of the single fibre compression test. The creep coefficient and stress index have been determined for electron beam evaporated physical vapour deposited Ti-6Al-4V at 900 deg. C to be 1.23 x 10{sup -5} and 1.3, respectively. Consolidation experiments have been carried out on multi-ply MCF arrays under vacuum hot pressing. Finite element models have been developed for the dynamic consolidation of both square and hexagonal fibre packings. The creep constants for the Ti-6Al-4V, determined using the single fibre test, were assigned to the coating in the finite element models. Excellent agreement between predicted and experimental results was achieved, providing verification of the single fibre test methodology for the determination of creep constants.

  15. TOPICAL REVIEW: Emergent geometry and gravity from matrix models: an introduction

    NASA Astrophysics Data System (ADS)

    Steinacker, Harold

    2010-07-01

    An introductory review to emergent noncommutative gravity within Yang-Mills matrix models is presented. Spacetime is described as a noncommutative brane solution of the matrix model, i.e. as a submanifold of {\\mathbb R}^D. Fields and matter on the brane arise as fluctuations of the bosonic resp. fermionic matrices around such a background, and couple to an effective metric interpreted in terms of gravity. Suitable tools are provided for the description of the effective geometry in the semi-classical limit. The relation to non-commutative gauge theory and the role of UV/IR mixing are explained. Several types of geometries are identified, in particular 'harmonic' and 'Einstein' types of solutions. The physics of the harmonic branch is discussed in some detail, emphasizing the non-standard role of vacuum energy. This may provide a new approach to some of the big puzzles in this context. The IKKT model with D = 10 and close relatives are singled out as promising candidates for quantum theory of fundamental interactions including gravity.

  16. Modeling the Effect of Oxidation on Tensile Strength of Carbon Fiber-Reinforced Ceramic-Matrix Composites

    NASA Astrophysics Data System (ADS)

    Longbiao, Li

    2015-12-01

    An analytical method has been developed to investigate the effect of oxidation on the tensile strength of carbon fiber - reinforced ceramic - matrix composites (CMCs). The Budiansky - Hutchinson - Evans shear - lag model was used to describe the micro stress field of the damaged composite considering fibers failure. The statistical matrix multicracking model and fracture mechanics interface debonding criterion were used to determine the matrix crack spacing and interface debonded length. The fiber strength degradation model and oxidation region propagation model have been adopted to analyze the oxidation effect on tensile strength of the composite, which is controlled by diffusion of oxygen gas through matrix cracks. Under tensile loading, the fibers failure probabilities were determined by combining oxidation model and fiber statistical failure model based on the assumption that fiber strength is subjected to two-parameter Weibull distribution and the loads carried by broken and intact fibers statisfy the global load sharing criterion. The composite can no longer support the applied load when the total loads supported by broken and intact fibers approach its maximum value. The conditions of a single matrix crack and matrix multicrackings for tensile strength considering oxidation time and temperature have been analyzed.

  17. Conductance statistics for the power-law banded random matrix model

    SciTech Connect

    Martinez-Mendoza, A. J.; Mendez-Bermudez, J. A.; Varga, Imre

    2010-12-21

    We study numerically the conductance statistics of the one-dimensional (1D) Anderson model with random long-range hoppings described by the Power-law Banded Random Matrix (PBRM) model. Within a scattering approach to electronic transport, we consider two scattering setups in absence and presence of direct processes: 2M single-mode leads attached to one side and to opposite sides of 1D circular samples. For both setups we show that (i) the probability distribution of the logarithm of the conductance T behaves as w(lnT){proportional_to}T{sup M2/2}, for T<<, for both the critical and the non-critical samples; and (ii) at criticality there is a smooth crossover from localized-like to delocalized-like behavior in the transport properties of the PBRM model by decreasing the fractality of its eigenstates.

  18. Computational modelling of large aluminium stabilized conductors in an indirectly cooled magnet matrix

    SciTech Connect

    Baynham, D.E.; Sampson, P.L.

    1996-07-01

    Many of the detector magnets in use for Particle Physics experiments are based on a common technology developed in the 1980s: indirect cooling, pure aluminium stabilized conductor and monolithic resin impregnation (DELPHI, ALEPH, H1, TOPAZ etc.). In such indirectly cooled magnets stable behavior is a balance between the transient heat removal capacity of the winding and the thermal disturbances. For the extrapolation in magnet technology towards LHC detectors it is important to understand more fully this stability balance. This paper describes computational modelling techniques developed to predict the behavior of conductors in an indirectly cooled magnet matrix. The verification of the model is based on experimental studies of a test coil for the DELPHI solenoid. The computational model has been used to carry out a parametric study of the stability of the conductors proposed for the ATLAS End Cap Toroids at LHC. Results of the parametric study are presented.

  19. Evaluation of higher order PMD effects using Jones matrix analytical models: a comparative study

    NASA Astrophysics Data System (ADS)

    Ferreira, M. F.

    2006-04-01

    A comparative study among the Jones matrix analytical models with high-order PMD is presented. The models that make use of an exponential expansion arrested up to second order or consider the dispersion vector as a Taylor series expansion do not give good results in the approximation of high-order PMD effects, because of the nonlimited behavior with respect to frequency of the modulus of their dispersion vectors. On the other hand, the analytical model which describes the dispersion vector as rotating on a circumference in the Stokes space is found to be the most accurate. Moreover, it can be used to obtain an analytical expression of the pulse broadening, which is often chosen as a quality-system parameter.

  20. A micro to macro approach to polymer matrix composites damage modeling : final LDRD report.

    SciTech Connect

    English, Shawn Allen; Brown, Arthur A.; Briggs, Timothy M.

    2013-12-01

    Capabilities are developed, verified and validated to generate constitutive responses using material and geometric measurements with representative volume elements (RVE). The geometrically accurate RVEs are used for determining elastic properties and damage initiation and propagation analysis. Finite element modeling of the meso-structure over the distribution of characterizing measurements is automated and various boundary conditions are applied. Plain and harness weave composites are investigated. Continuum yarn damage, softening behavior and an elastic-plastic matrix are combined with known materials and geometries in order to estimate the macroscopic response as characterized by a set of orthotropic material parameters. Damage mechanics and coupling effects are investigated and macroscopic material models are demonstrated and discussed. Prediction of the elastic, damage, and failure behavior of woven composites will aid in macroscopic constitutive characterization for modeling and optimizing advanced composite systems.

  1. Spatially-explicit matrix models. A mathematical analysis of stage-structured integrodifference equations.

    PubMed

    Lutscher, Frithjof; Lewis, Mark A

    2004-03-01

    This paper is concerned with mathematical analysis of the 'critical domain-size' problem for structured populations. Space is introduced explicitly into matrix models for stage-structured populations. Movement of individuals is described by means of a dispersal kernel. The mathematical analysis investigates conditions for existence, stability and uniqueness of equilibrium solutions as well as some bifurcation behaviors. These mathematical results are linked to species persistence or extinction in connected habitats of different sizes or fragmented habitats; hence the framework is given for application of such models to ecology. Several approximations which reduce the complexity of integrodifference equations are given. A simple example is worked out to illustrate the analytical results and to compare the behavior of the integrodifference model to that of the approximations.

  2. Polarization aberration modeling via Jones matrix in the context of OPC

    NASA Astrophysics Data System (ADS)

    Zhang, Qiaolin; Song, Hua; Lucas, Kevin

    2007-10-01

    The increasingly stringent demand for shrinkage of IC device dimensions has been pushing the development of new resolution enhancement technologies in micro-lithography. High NA and Ultra-High NA (NA>1.0) applications for low k I imaging strongly demand the adoption of polarized illumination as a resolution enhancement technology since proper illumination polarization configuration can greatly improve the image contrast hence pattern printing fidelity. For polarized illumination to be fully effective, ideally all the components in the optical system should not alter the polarization state during propagation from illuminator to wafer surface. In current OPC modeling tools, it is typically assumed that the amplitude and polarization state of the electric field do not change as it passes through the projection lens pupil. However, in reality, the projection lens pupil of the scanner does change the amplitude and the polarization state to some extent, and ignorance of projection pupil induced polarization state and amplitude changes may cause CD errors which are un-tolerable at the 45nm device generation and beyond. We developed an OPC-deployable modeling approach to model polarization aberration imposed by the projection lens pupil via Jones matrix format. This polarization aberration modeling capability has been integrated into the Synopsys OPC modeling tool, ProGen, and its accuracy and efficiency have been validated by comparing with an industry standard lithography simulator SolidE. Our OPC simulations show that the impact of projection lens pupil polarization aberrations on optical proximity effect (OPE) could be as large as several nanometers, which is not negligible given the extremely stringent CD error budget at 45nm node and beyond. This modeling approach is applicable to arbitrary polarization aberrations imposed by any components in the lithography system that can be characterized in Jones matrix format. Based on an experimentally measured Jones matrix

  3. Probabilistic Residual Strength Model Developed for Life Prediction of Ceramic Matrix Composites

    NASA Technical Reports Server (NTRS)

    Thomas, David J.; Verrilli, Michael J.; Calomino, Anthony M.

    2004-01-01

    For the next generation of reusable launch vehicles, NASA is investigating introducing ceramic matrix composites (CMCs) in place of current superalloys for structural propulsion applications (e.g., nozzles, vanes, combustors, and heat exchangers). The higher use temperatures of CMCs will reduce vehicle weight by eliminating and/or reducing cooling system requirements. The increased strength-to-weight ratio of CMCs relative to superalloys further enhances their weight savings potential. However, in order to provide safe designs for components made of these new materials, a comprehensive life prediction methodology for CMC structures needs to be developed. A robust methodology for lifing composite structures has yet to be adopted by the engineering community. Current industry design practice continues to utilize deterministic empirically based models borrowed from metals design for predicting material life capabilities. The deterministic nature of these models inadequately addresses the stochastic character of brittle composites, and their empirical reliance makes predictions beyond the experimental test conditions a risky extrapolation. A team of engineers at the NASA Glenn Research Center has been developing a new life prediction engineering model. The Probabilistic Residual Strength (PRS) model uses the residual strength of the composite as its damage metric. Expected life and material strength are both considered probabilistically to account for the observed stochastic material response. Extensive experimental testing has been carried out on C/SiC (a candidate aerospace CMC material system) in a controlled 1000 ppm O2/argon environment at elevated temperatures of 800 and 1200 C. The test matrix was established to allow observation of the material behavior, characterization of the model, and validation of the model's predictive capabilities. Sample results of the validation study are illustrated in the graphs.

  4. Multiscale computational model of fluid flow and matrix deformation in decellularized liver.

    PubMed

    Nishii, Kenichiro; Reese, Greg; Moran, Emma C; Sparks, Jessica L

    2016-04-01

    Currently little is known about the biomechanical environment in decellularized tissue. The goal of this research is to quantify the mechanical microenvironment in decellularized liver, for varying organ-scale perfusion conditions, using a combined experimental/computational approach. Needle-guided ultra-miniature pressure sensors were inserted into liver tissue to measure parenchymal fluid pressure ex-situ in portal vein-perfused native (n=5) and decellularized (n=7) ferret liver, for flow rates from 3-12mL/min. Pressures were also recorded at the inlet near the portal vein cannula to estimate total vascular resistance of the specimens. Experimental results were fit to a multiscale computational model to simulate perfusion conditions inside native versus decellularized livers for four experimental flow rates. The multiscale model consists of two parts: an organ-scale electrical analog model of liver hemodynamics and a tissue-scale model that predicts pore fluid pressure, pore fluid velocity, and solid matrix stress and deformation throughout the 3D hepatic lobule. Distinct models were created for native versus decellularized liver. Results show that vascular resistance decreases by 82% as a result of decellularization. The hydraulic conductivity of the decellularized liver lobule, a measure of tissue permeability, was 5.6 times that of native liver. For the four flow rates studied, mean fluid pressures in the decellularized lobule were 0.6-2.4mmHg, mean fluid velocities were 211-767μm/s, and average solid matrix principal strains were 1.7-6.1%. In the future this modeling platform can be used to guide the optimization of perfusion seeding and conditioning strategies for decellularized scaffolds in liver bioengineering.

  5. Ability of matrix models to explain the past and predict the future of plant populations.

    PubMed

    Crone, Elizabeth E; Ellis, Martha M; Morris, William F; Stanley, Amanda; Bell, Timothy; Bierzychudek, Paulette; Ehrlén, Johan; Kaye, Thomas N; Knight, Tiffany M; Lesica, Peter; Oostermeijer, Gerard; Quintana-Ascencio, Pedro F; Ticktin, Tamara; Valverde, Teresa; Williams, Jennifer L; Doak, Daniel F; Ganesan, Rengaian; McEachern, Kathyrn; Thorpe, Andrea S; Menges, Eric S

    2013-10-01

    Uncertainty associated with ecological forecasts has long been recognized, but forecast accuracy is rarely quantified. We evaluated how well data on 82 populations of 20 species of plants spanning 3 continents explained and predicted plant population dynamics. We parameterized stage-based matrix models with demographic data from individually marked plants and determined how well these models forecast population sizes observed at least 5 years into the future. Simple demographic models forecasted population dynamics poorly; only 40% of observed population sizes fell within our forecasts' 95% confidence limits. However, these models explained population dynamics during the years in which data were collected; observed changes in population size during the data-collection period were strongly positively correlated with population growth rate. Thus, these models are at least a sound way to quantify population status. Poor forecasts were not associated with the number of individual plants or years of data. We tested whether vital rates were density dependent and found both positive and negative density dependence. However, density dependence was not associated with forecast error. Forecast error was significantly associated with environmental differences between the data collection and forecast periods. To forecast population fates, more detailed models, such as those that project how environments are likely to change and how these changes will affect population dynamics, may be needed. Such detailed models are not always feasible. Thus, it may be wiser to make risk-averse decisions than to expect precise forecasts from models.

  6. Ability of matrix models to explain the past and predict the future of plant populations.

    USGS Publications Warehouse

    McEachern, Kathryn; Crone, Elizabeth E.; Ellis, Martha M.; Morris, William F.; Stanley, Amanda; Bell, Timothy; Bierzychudek, Paulette; Ehrlen, Johan; Kaye, Thomas N.; Knight, Tiffany M.; Lesica, Peter; Oostermeijer, Gerard; Quintana-Ascencio, Pedro F.; Ticktin, Tamara; Valverde, Teresa; Williams, Jennifer I.; Doak, Daniel F.; Ganesan, Rengaian; Thorpe, Andrea S.; Menges, Eric S.

    2013-01-01

    Uncertainty associated with ecological forecasts has long been recognized, but forecast accuracy is rarely quantified. We evaluated how well data on 82 populations of 20 species of plants spanning 3 continents explained and predicted plant population dynamics. We parameterized stage-based matrix models with demographic data from individually marked plants and determined how well these models forecast population sizes observed at least 5 years into the future. Simple demographic models forecasted population dynamics poorly; only 40% of observed population sizes fell within our forecasts' 95% confidence limits. However, these models explained population dynamics during the years in which data were collected; observed changes in population size during the data-collection period were strongly positively correlated with population growth rate. Thus, these models are at least a sound way to quantify population status. Poor forecasts were not associated with the number of individual plants or years of data. We tested whether vital rates were density dependent and found both positive and negative density dependence. However, density dependence was not associated with forecast error. Forecast error was significantly associated with environmental differences between the data collection and forecast periods. To forecast population fates, more detailed models, such as those that project how environments are likely to change and how these changes will affect population dynamics, may be needed. Such detailed models are not always feasible. Thus, it may be wiser to make risk-averse decisions than to expect precise forecasts from models.

  7. Modelling of Fiber/Matrix Debonding of Composites Under Cyclic Loading

    NASA Technical Reports Server (NTRS)

    Naghipour, Paria; Pineda, Evan J.; Bednarcyk, Brett A.; Arnold, Steven M.

    2013-01-01

    The micromechanics theory, generalized method of cells (GMC), was employed to simulate the debonding of fiber/matrix interfaces, within a repeating unit cell subjected to global, cyclic loading, utilizing a cyclic crack growth law. Cycle dependent, interfacial debonding was implemented as a new module to the available GMC formulation. The degradation of interfacial stresses, with applied load cycles, was achieved via progressive evolution of the interfacial compliance. A periodic repeating unit cell, representing the fiber/matrix architecture of a composite, was subjected to combined normal and shear loadings, and degradation of the global transverse stress in successive cycles was monitored. The obtained results were compared to values from a corresponding finite element model. Reasonable agreement was achieved for combined normal and shear loading conditions, with minimal variation for pure loading cases. The local effects of interfacial debonding, and fatigue damage will later be combined as sub-models to predict the experimentally obtained fatigue life of Ti-15-3/Sic composites at the laminate level.

  8. Modeling of the viscoelastic behavior of a polyimide matrix at elevated temperature

    NASA Astrophysics Data System (ADS)

    Crochon, Thibaut

    Use of Polymer Matrix Composite Materials (PMCMs) in aircraft engines requires materials able to withstand extreme service conditions, such as elevated temperatures, high mechanical loadings and an oxidative environment. In such an environment, the polymer matrix is likely to exhibit a viscoelastic behavior dependent on the mechanical loading and temperature. In addition, the combined effects of elevated temperature and the environment near the engines are likely to increase physical as well as chemical aging. These various parameters need to be taken into consideration for the designer to be able to predict the material behavior over the service life of the components. The main objective of this thesis was to study the viscoelastic behavior of a high temperature polyimide matrix and develop a constitutive theory able to predict the material behavior for every of service condition. Then, the model had to have to be implemented into commercially available finite-element software such as ABAQUS or ANSYS. Firstly, chemical aging of the material at service temperature was studied. To that end, a thermogravimetric analysis of the matrix was conducted on powder samples in air atmosphere. Two kinds of tests were performed: i) kinetic tests in which powder samples were heated at a constant rate until complete sublimation; ii) isothermal tests in which the samples were maintained at a constant temperature for 24 hours. The first tests were used to develop a degradation model, leading to an excellent fit of the experimental data. Then, the model was used to predict the isothermal data but which much less success, particularly for the lowest temperatures. At those temperatures, the chemical degradation was preceded by an oxidation phase which the model was not designed to predict. Other isothermal degradation tests were also performed on tensile tests samples instead of powders. Those tests were conducted at service temperature for a much longer period of time. The samples

  9. Altered Chondrocyte Differentiation and Extracellular Matrix Homeostasis in a Zebrafish Model for Mucolipidosis II

    PubMed Central

    Flanagan-Steet, Heather; Sias, Christina; Steet, Richard

    2009-01-01

    Mucolipidosis II (ML-II) is a pediatric disorder caused by defects in the biosynthesis of mannose 6-phosphate, the carbohydrate recognition signal responsible for targeting certain acid hydrolases to lysosomes. The mechanisms underlying the developmental defects of ML-II are largely unknown due in part to the lack of suitable animal models. To overcome these limitations, we developed a model for ML-II in zebrafish by inhibiting the expression of N-acetylglucosamine-1-phosphotransferase, the enzyme that initiates mannose 6-phosphate biosynthesis. Morphant embryos manifest craniofacial defects, impaired motility, and abnormal otolith and pectoral fin development. Decreased mannose phosphorylation of several lysosomal glycosidases was observed in morphant lysates, consistent with the reduction in phosphotransferase activity. Investigation of the craniofacial defects in the morphants uncovered striking changes in the timing and localization of both type II collagen and Sox9 expression, suggestive of an accelerated chondrocyte differentiation program. Accumulation of type II collagen was also noted within misshapen cartilage elements at later stages of development. Furthermore, we observed abnormal matrix formation and calcium deposition in morphant otoliths. Collectively, these data provide new insight into the developmental pathology of ML-II and suggest that altered production and/or homeostasis of extracellular matrix proteins are integral to the disease process. These findings highlight the potential of the zebrafish system in studying lysosomal disease pathogenesis. PMID:19834066

  10. Development of a 3D matrix for modeling mammalian spinal cord injury in vitro.

    PubMed

    Diaz Quiroz, Juan Felipe; Li, Yuping; Aparicio, Conrado; Echeverri, Karen

    2016-11-01

    Spinal cord injury affects millions of people around the world, however, limited therapies are available to improve the quality of life of these patients. Spinal cord injury is usually modeled in rats and mice using contusion or complete transection models and this has led to a deeper understanding of the molecular and cellular complexities of the injury. However, it has not to date led to development of successful novel therapies, this is in part due to the complexity of the injury and the difficulty of deciphering the exact roles and interactions of different cells within this complex environment. Here we developed a collagen matrix that can be molded into the 3D tubular shape with a lumen and can hence support cell interactions in a similar architecture to a spinal cord. We show that astrocytes can be successfully grown on this matrix in vitro and when injured, the cells respond as they do in vivo and undergo reactive gliosis, one of the steps that lead to formation of a glial scar, the main barrier to spinal cord regeneration. In the future, this system can be used to quickly assess the effect of drugs on glial scar protein activity or to perform live imaging of labeled cells after exposure to drugs.

  11. Modeling Optical Properties of Polluted Dust and its Morphological Effects by T-Matrix Method

    NASA Astrophysics Data System (ADS)

    Xu, G.; Yang, P.; Brooks, S. D.

    2015-12-01

    Dust storms largely contribute to regional or global aerosol loads, influence radiative energy budget, and air quality, and cause atmospheric environmental, public health problems. As dusts are transported long distances, aerosols such as black carbon can pollute the air mass along the transport path. Two mixing processes, externally and semi-externally (sticking) mixing may substantially affect the single-scattering and radiative properties of polluted dust particles compared to the unpolluted counterparts. This study focuses on quantifying the changes in the optical properties of dust aerosols due to black carbon contamination. The dust model we use is an irregular polyhedron, which is in good agreement with the laboratory measurement. The black carbon model is spherules aggregate defined with a cluster-cluster aggregation algorithm. Specifically, we define the degree of pollution in terms of two variables, the adhesion degree of pollutants and their mixing ratios, since both can alter the optical properties of polluted dust in different ways. By applying the Invariant Imbedding T-matrix Method (II-TM), we obtain the scattering phase matrix and other optical properties of dust aerosols with different degrees of contamination. Furthermore, the morphological effects on the optical properties of polluted dust are quantified by considering different fractal dimensions of black carbon as particles age. The overall changes due to different degrees of pollution by black carbon are investigated at various wavelengths.

  12. Development of a 3D matrix for modeling mammalian spinal cord injury in vitro

    PubMed Central

    Diaz Quiroz, Juan Felipe; Li, Yuping; Aparicio, Conrado; Echeverri, Karen

    2016-01-01

    Spinal cord injury affects millions of people around the world, however, limited therapies are available to improve the quality of life of these patients. Spinal cord injury is usually modeled in rats and mice using contusion or complete transection models and this has led to a deeper understanding of the molecular and cellular complexities of the injury. However, it has not to date led to development of successful novel therapies, this is in part due to the complexity of the injury and the difficulty of deciphering the exact roles and interactions of different cells within this complex environment. Here we developed a collagen matrix that can be molded into the 3D tubular shape with a lumen and can hence support cell interactions in a similar architecture to a spinal cord. We show that astrocytes can be successfully grown on this matrix in vitro and when injured, the cells respond as they do in vivo and undergo reactive gliosis, one of the steps that lead to formation of a glial scar, the main barrier to spinal cord regeneration. In the future, this system can be used to quickly assess the effect of drugs on glial scar protein activity or to perform live imaging of labeled cells after exposure to drugs. PMID:28123426

  13. Hydrogel core flexible matrix composite (H-FMC) actuators: theory and preliminary modelling

    NASA Astrophysics Data System (ADS)

    Dicker, M. P. M.; Weaver, P. M.; Rossiter, J. M.; Bond, I. P.

    2014-09-01

    The underlying theory of a new actuator concept based on hydrogel core flexible matrix composites (H-FMC) is presented. The key principle that underlines the H-FMC actuator operation is that the three-dimensional swelling of a hydrogel is partially constrained in order to improve the amount of useful work done. The partial constraint is applied to the hydrogel by a flexible matrix composite (FMC) that minimizes the hydrogel's volume expansion while swelling. This constraint serves to maximize the fixed charge density and resulting osmotic pressure, the driving force behind actuation. In addition, for certain FMC fibre orientations the Poisson's ratio of the anisotropic FMC laminate converts previously unused hydrogel swelling in the radial and circumferential directions into useful axial strains. The potential benefit of the H-FMC concept to hydrogel actuator performance is shown through comparison of force-stroke curves and evaluation of improvements in useful actuation work. The model used to achieve this couples chemical and electrical components, represented with the Nernst-Plank and Poisson equations, as well as a linear elastic mechanical material model, encompassing limited geometric nonlinearities. It is found that improvements in useful actuation work in the order of 1500% over bare hydrogel performance are achieved by the H-FMC concept. A parametric study is also undertaken to determine the effect of various FMC design parameters on actuator free strain and blocking stress. A comparison to other actuator concepts is also included.

  14. A matrix dependent/algebraic multigrid approach for extruded meshes with applications to ice sheet modeling

    SciTech Connect

    Tuminaro, Raymond S.; Perego, Mauro; Tezaur, Irina Kalashnikova; Salinger, Andrew G.; Price, Stephen

    2016-10-06

    A multigrid method is proposed that combines ideas from matrix dependent multigrid for structured grids and algebraic multigrid for unstructured grids. It targets problems where a three-dimensional mesh can be viewed as an extrusion of a two-dimensional, unstructured mesh in a third dimension. Our motivation comes from the modeling of thin structures via finite elements and, more specifically, the modeling of ice sheets. Extruded meshes are relatively common for thin structures and often give rise to anisotropic problems when the thin direction mesh spacing is much smaller than the broad direction mesh spacing. Within our approach, the first few multigrid hierarchy levels are obtained by applying matrix dependent multigrid to semicoarsen in a structured thin direction fashion. After sufficient structured coarsening, the resulting mesh contains only a single layer corresponding to a two-dimensional, unstructured mesh. Algebraic multigrid can then be employed in a standard manner to create further coarse levels, as the anisotropic phenomena is no longer present in the single layer problem. The overall approach remains fully algebraic, with the minor exception that some additional information is needed to determine the extruded direction. Furthermore, this facilitates integration of the solver with a variety of different extruded mesh applications.

  15. A matrix dependent/algebraic multigrid approach for extruded meshes with applications to ice sheet modeling

    DOE PAGES

    Tuminaro, Raymond S.; Perego, Mauro; Tezaur, Irina Kalashnikova; ...

    2016-10-06

    A multigrid method is proposed that combines ideas from matrix dependent multigrid for structured grids and algebraic multigrid for unstructured grids. It targets problems where a three-dimensional mesh can be viewed as an extrusion of a two-dimensional, unstructured mesh in a third dimension. Our motivation comes from the modeling of thin structures via finite elements and, more specifically, the modeling of ice sheets. Extruded meshes are relatively common for thin structures and often give rise to anisotropic problems when the thin direction mesh spacing is much smaller than the broad direction mesh spacing. Within our approach, the first few multigridmore » hierarchy levels are obtained by applying matrix dependent multigrid to semicoarsen in a structured thin direction fashion. After sufficient structured coarsening, the resulting mesh contains only a single layer corresponding to a two-dimensional, unstructured mesh. Algebraic multigrid can then be employed in a standard manner to create further coarse levels, as the anisotropic phenomena is no longer present in the single layer problem. The overall approach remains fully algebraic, with the minor exception that some additional information is needed to determine the extruded direction. Furthermore, this facilitates integration of the solver with a variety of different extruded mesh applications.« less

  16. Continuum Damage Modeling for Dynamic Fracture Toughness of Metal Matrix Composites

    NASA Astrophysics Data System (ADS)

    Lee, Intaek; Ochi, Yasuo; Bae, Sungin; Song, Jungil

    Short fiber reinforced metal-matrix composites (MMCs) have widely adopted as structural materials and many experimental researches have been performed to study fracture toughness of it. Fracture toughness is often referred as the plane strain(maximum constraint) fracture toughness KIc determined by the well-established standard test method, such as ASTM E399. But the application for dynamic fracture toughness KId has not been popular yet, because of reliance in capturing the crack propagating time. This paper deals with dynamic fracture toughness testing and simulation using finite element method to evaluate fracture behaviors of MMCs manufactured by squeeze casting process when material combination is varied with the type of reinforcement (appearance, size), volume fraction and combination of reinforcements, and the matrix alloy. The instrumented Charphy impact test was used for KId determination and continuum damage model embedded in commercial FE program is used to investigate the dynamic fracture toughness with the influence of elasto-visco-plastic constitutive relation of quasi-brittle fracture that is typical examples of ceramics and some fibre reinforced composites. With Compared results between experimental method and FE simulation, the determination process for KId is presented. FE simulation coupled with continuum damage model is emphasized single shot simulation can predict the dynamic fracture toughness, KId and real time evolution of that directly.

  17. Carbon isotope composition of ambient CO2 and recycling: a matrix simulation model

    USGS Publications Warehouse

    da Silveira Lobo Sternberg, Leonel; DeAngelis, Donald L.

    2002-01-01

    The relationship between isotopic composition and concentration of ambient CO2 in a canopy and its associated convective boundary layer was modeled. The model divides the canopy and convective boundary layer into several layers. Photosynthesis, respiration, and exchange between each layer can be simulated by matrix equations. This simulation can be used to calculate recycling; defined here as the amount of respired CO2 re-fixed by photosynthesis relative to the total amount of respired CO2. At steady state the matrix equations can be solved for the canopy and convective boundary layer CO2 concentration and isotopic profile, which can be used to calculate a theoretical recycling index according to a previously developed equation. There is complete agreement between simulated and theoretical recycling indices for different exchange scenarios. Recycling indices from a simulation of gas exchange between a heterogeneous vegetation canopy and the troposphere also agreed with a more generalized form of the theoretical recycling equation developed here.

  18. Comparison of Damage Models for Predicting the Non-Linear Response of Laminates Under Matrix Dominated Loading Conditions

    NASA Technical Reports Server (NTRS)

    Schuecker, Clara; Davila, Carlos G.; Rose, Cheryl A.

    2010-01-01

    Five models for matrix damage in fiber reinforced laminates are evaluated for matrix-dominated loading conditions under plane stress and are compared both qualitatively and quantitatively. The emphasis of this study is on a comparison of the response of embedded plies subjected to a homogeneous stress state. Three of the models are specifically designed for modeling the non-linear response due to distributed matrix cracking under homogeneous loading, and also account for non-linear (shear) behavior prior to the onset of cracking. The remaining two models are localized damage models intended for predicting local failure at stress concentrations. The modeling approaches of distributed vs. localized cracking as well as the different formulations of damage initiation and damage progression are compared and discussed.

  19. Evaluation of several micromechanics models for discontinuously reinforced metal matrix composites

    NASA Technical Reports Server (NTRS)

    Johnson, W. Steven; Birt, M. J.

    1990-01-01

    A systematic experimental evaluation of whisker and particulate reinforced aluminum matrix composites was conducted to assess the variation in tensile properties with reinforcement type, volume fraction, and specimen thickness. Each material was evaluated in three thicknesses, 1.8, 3.18, and 6.35 mm, to determine the size, distribution, and orientation of the reinforcements. This information was used to evaluate several micromechanical models that predict composite moduli. The longitudinal and transverse moduli were predicted for reinforced aluminum. The Paul model, the Cox model and the Halpin-Tsai model were evaluated. The Paul model gave a good upper bound prediction for the particulate reinforced composites but under predicted whisker reinforced composite moduli. The Cox model gave good moduli predictions for the whisker reinforcement, but was too low for the particulate. The Halpin-Tsai model gave good results for both whisker and particulate reinforced composites. An approach using a trigonometric projection of whisker length to predict the fiber contribution to the modulus in the longitudinal and transverse directions was compared to the more conventional lamination theory approach.

  20. A framework for studying transient dynamics of population projection matrix models.

    PubMed

    Stott, Iain; Townley, Stuart; Hodgson, David James

    2011-09-01

    Empirical models are central to effective conservation and population management, and should be predictive of real-world dynamics. Available modelling methods are diverse, but analysis usually focuses on long-term dynamics that are unable to describe the complicated short-term time series that can arise even from simple models following ecological disturbances or perturbations. Recent interest in such transient dynamics has led to diverse methodologies for their quantification in density-independent, time-invariant population projection matrix (PPM) models, but the fragmented nature of this literature has stifled the widespread analysis of transients. We review the literature on transient analyses of linear PPM models and synthesise a coherent framework. We promote the use of standardised indices, and categorise indices according to their focus on either convergence times or transient population density, and on either transient bounds or case-specific transient dynamics. We use a large database of empirical PPM models to explore relationships between indices of transient dynamics. This analysis promotes the use of population inertia as a simple, versatile and informative predictor of transient population density, but criticises the utility of established indices of convergence times. Our findings should guide further development of analyses of transient population dynamics using PPMs or other empirical modelling techniques.

  1. UTOPIAN: user-driven topic modeling based on interactive nonnegative matrix factorization.

    PubMed

    Choo, Jaegul; Lee, Changhyun; Reddy, Chandan K; Park, Haesun

    2013-12-01

    Topic modeling has been widely used for analyzing text document collections. Recently, there have been significant advancements in various topic modeling techniques, particularly in the form of probabilistic graphical modeling. State-of-the-art techniques such as Latent Dirichlet Allocation (LDA) have been successfully applied in visual text analytics. However, most of the widely-used methods based on probabilistic modeling have drawbacks in terms of consistency from multiple runs and empirical convergence. Furthermore, due to the complicatedness in the formulation and the algorithm, LDA cannot easily incorporate various types of user feedback. To tackle this problem, we propose a reliable and flexible visual analytics system for topic modeling called UTOPIAN (User-driven Topic modeling based on Interactive Nonnegative Matrix Factorization). Centered around its semi-supervised formulation, UTOPIAN enables users to interact with the topic modeling method and steer the result in a user-driven manner. We demonstrate the capability of UTOPIAN via several usage scenarios with real-world document corpuses such as InfoVis/VAST paper data set and product review data sets.

  2. A Phenomenological Model for Tool Wear in Friction Stir Welding of Metal Matrix Composites

    NASA Astrophysics Data System (ADS)

    Prater, Tracie J.; Strauss, Alvin M.; Cook, George E.; Gibson, Brian T.; Cox, Chase D.

    2013-08-01

    Friction stir welding (FSW) of metal matrix composites (MMCs) is advantageous because the solid-state nature of the process precludes formation of deleterious intermetallic phases which accompany melting. FSW of MMCs is complicated by rapid and severe wear of the welding tool, a consequence of contact between the tool and the much harder abrasive reinforcement which gives the workpiece material its enhanced strength. The current article demonstrates that Nunes's rotating plug model of material flow in FSW, which has been successfully applied in many other contexts, can also help us understand wear in FSW of MMCs. An equation for predicting the amount of wear in this application is developed and compared with experimental data. This phenomenological model explains the relationship between wear and FSW process parameters documented in previous studies.

  3. Decellularized extracellular matrix microparticles as a vehicle for cellular delivery in a model of anastomosis healing.

    PubMed

    Hoganson, David M; Owens, Gwen E; Meppelink, Amanda M; Bassett, Erik K; Bowley, Chris M; Hinkel, Cameron J; Finkelstein, Eric B; Goldman, Scott M; Vacanti, Joseph P

    2016-07-01

    Extracellular matrix (ECM) materials from animal and human sources have become important materials for soft tissue repair. Microparticles of ECM materials have increased surface area and exposed binding sites compared to sheet materials. Decellularized porcine peritoneum was mechanically dissociated into 200 µm microparticles, seeded with fibroblasts and cultured in a low gravity rotating bioreactor. The cells avidly attached and maintained excellent viability on the microparticles. When the seeded microparticles were placed in a collagen gel, the cells quickly migrated off the microparticles and through the gel. Cells from seeded microparticles migrated to and across an in vitro anastomosis model, increasing the tensile strength of the model. Cell seeded microparticles of ECM material have potential for paracrine and cellular delivery therapies when delivered in a gel carrier. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 1728-1735, 2016.

  4. Pulsed radiolysis of model aromatic polymers and epoxy based matrix materials

    NASA Technical Reports Server (NTRS)

    Gupta, A.; Moacanin, J.; Liang, R.; Coulter, D.

    1982-01-01

    Models of primary processes leading to deactivation of energy deposited by a pulse of high energy electrons were derived for epoxy matrix materials and polyl-vinyl naphthalene. The basic conclusion is that recombination of initially formed charged states is complete within 1 nanosecond, and subsequent degradation chemistry is controlled by the reactivity of these excited states. Excited states in both systems form complexes with ground state molecules. These excimers or exciplexes have their characteristics emissive and absorptive properties and may decay to form separated pairs of ground state molecules, cross over to the triplet manifold or emit fluorescence. ESR studies and chemical analyses subsequent to pulse radiolysis were performed in order to estimate bond cleavage probabilities and net reaction rates. The energy deactivation models which were proposed to interpret these data have led to the development of radiation stabilization criteria for these systems.

  5. Standard Model anatomy of WIMP dark matter direct detection. II. QCD analysis and hadronic matrix elements

    NASA Astrophysics Data System (ADS)

    Hill, Richard J.; Solon, Mikhail P.

    2015-02-01

    Models of weakly interacting massive particles (WIMPs) specified at the electroweak scale are systematically matched to effective theories at hadronic scales where WIMP-nucleus scattering observables are evaluated. Anomalous dimensions and heavy-quark threshold matching conditions are computed for the complete basis of lowest-dimension effective operators involving quarks and gluons. The resulting QCD renormalization group evolution equations are solved. The status of relevant hadronic matrix elements is reviewed and phenomenological illustrations are given, including details for the computation of the universal limit of nucleon scattering with heavy S U (2 )W×U (1 )Y charged WIMPs. Several cases of previously underestimated hadronic uncertainties are isolated. The results connect arbitrary models specified at the electroweak scale to a basis of nf=3 -flavor QCD operators. The complete basis of operators and Lorentz invariance constraints through order v2/c2 in the nonrelativistic nucleon effective theory are derived.

  6. Density-matrix based determination of low-energy model Hamiltonians from ab initio wavefunctions.

    PubMed

    Changlani, Hitesh J; Zheng, Huihuo; Wagner, Lucas K

    2015-09-14

    We propose a way of obtaining effective low energy Hubbard-like model Hamiltonians from ab initio quantum Monte Carlo calculations for molecular and extended systems. The Hamiltonian parameters are fit to best match the ab initio two-body density matrices and energies of the ground and excited states, and thus we refer to the method as ab initio density matrix based downfolding. For benzene (a finite system), we find good agreement with experimentally available energy gaps without using any experimental inputs. For graphene, a two dimensional solid (extended system) with periodic boundary conditions, we find the effective on-site Hubbard U(∗)/t to be 1.3 ± 0.2, comparable to a recent estimate based on the constrained random phase approximation. For molecules, such parameterizations enable calculation of excited states that are usually not accessible within ground state approaches. For solids, the effective Hamiltonian enables large-scale calculations using techniques designed for lattice models.

  7. Modeling of drug release from matrix systems involving moving boundaries: approximate analytical solutions.

    PubMed

    Lee, Ping I

    2011-10-10

    The purpose of this review is to provide an overview of approximate analytical solutions to the general moving boundary diffusion problems encountered during the release of a dispersed drug from matrix systems. Starting from the theoretical basis of the Higuchi equation and its subsequent improvement and refinement, available approximate analytical solutions for the more complicated cases involving heterogeneous matrix, boundary layer effect, finite release medium, surface erosion, and finite dissolution rate are also discussed. Among various modeling approaches, the pseudo-steady state assumption employed in deriving the Higuchi equation and related approximate analytical solutions appears to yield reasonably accurate results in describing the early stage release of a dispersed drug from matrices of different geometries whenever the initial drug loading (A) is much larger than the drug solubility (C(s)) in the matrix (or A≫C(s)). However, when the drug loading is not in great excess of the drug solubility (i.e. low A/C(s) values) or when the drug loading approaches the drug solubility (A→C(s)) which occurs often with drugs of high aqueous solubility, approximate analytical solutions based on the pseudo-steady state assumption tend to fail, with the Higuchi equation for planar geometry exhibiting a 11.38% error as compared with the exact solution. In contrast, approximate analytical solutions to this problem without making the pseudo-steady state assumption, based on either the double-integration refinement of the heat balance integral method or the direct simplification of available exact analytical solutions, show close agreement with the exact solutions in different geometries, particularly in the case of low A/C(s) values or drug loading approaching the drug solubility (A→C(s)). However, the double-integration heat balance integral approach is generally more useful in obtaining approximate analytical solutions especially when exact solutions are not

  8. Role of vertex corrections in the matrix formulation of the random phase approximation for the multiorbital Hubbard model

    NASA Astrophysics Data System (ADS)

    Altmeyer, Michaela; Guterding, Daniel; Hirschfeld, P. J.; Maier, Thomas A.; Valentí, Roser; Scalapino, Douglas J.

    2016-12-01

    In the framework of a multiorbital Hubbard model description of superconductivity, a matrix formulation of the superconducting pairing interaction that has been widely used is designed to treat spin, charge, and orbital fluctuations within a random phase approximation (RPA). In terms of Feynman diagrams, this takes into account particle-hole ladder and bubble contributions as expected. It turns out, however, that this matrix formulation also generates additional terms which have the diagrammatic structure of vertex corrections. Here we examine these terms and discuss the relationship between the matrix-RPA superconducting pairing interaction and the Feynman diagrams that it sums.

  9. Study on a three-dimensional testing method coupling with a leaching behavior model for solidified waste matrix.

    PubMed

    Liu, Kuen-Shan; Li, Kung-Cheh

    2008-05-01

    The objective of this study was to develop a three-dimensional leaching method to understand the diffusion behavior of a solidified waste matrix. A cylindrical solidified waste matrix with isotope lead compounds used as a tracer was used to demonstrate the diffusion phenomenon. The leaching test method was coupled with the mathematical diffusion model derived from Duhamel's theorem to control the time-dependent conditions and compute the mass diffusivity and mass generation rate constant of the target pollutants and also simulate the pollutants leached from solidified waste matrix. The simulation value is in fair agreement with experiment.

  10. Tuning stochastic matrix models with hydrologic data to predict the population dynamics of a riverine fish

    USGS Publications Warehouse

    Sakaris, P.C.; Irwin, E.R.

    2010-01-01

    We developed stochastic matrix models to evaluate the effects of hydrologic alteration and variable mortality on the population dynamics of a lotie fish in a regulated river system. Models were applied to a representative lotic fish species, the flathead catfish (Pylodictis olivaris), for which two populations were examined: a native population from a regulated reach of the Coosa River (Alabama, USA) and an introduced population from an unregulated section of the Ocmulgee River (Georgia, USA). Size-classified matrix models were constructed for both populations, and residuals from catch-curve regressions were used as indices of year class strength (i.e., recruitment). A multiple regression model indicated that recruitment of flathead catfish in the Coosa River was positively related to the frequency of spring pulses between 283 and 566 m3/s. For the Ocmulgee River population, multiple regression models indicated that year class strength was negatively related to mean March discharge and positively related to June low flow. When the Coosa population was modeled to experience five consecutive years of favorable hydrologic conditions during a 50-year projection period, it exhibited a substantial spike in size and increased at an overall 0.2% annual rate. When modeled to experience five years of unfavorable hydrologic conditions, the Coosa population initially exhibited a decrease in size but later stabilized and increased at a 0.4% annual rate following the decline. When the Ocmulgee River population was modeled to experience five years of favorable conditions, it exhibited a substantial spike in size and increased at an overall 0.4% annual rate. After the Ocmulgee population experienced five years of unfavorable conditions, a sharp decline in population size was predicted. However, the population quickly recovered, with population size increasing at a 0.3% annual rate following the decline. In general, stochastic population growth in the Ocmulgee River was more

  11. Evidence for the use of organic carbon as the sorbing matrix in the modeling of PCB accumulation in phytoplankton

    SciTech Connect

    Skoglung, R.S.; Swackhamer, D.L.

    1999-05-01

    This report presents empirical evidence for the use of organic carbon as the sorbing matrix in the kinetic modeling of PCB accumulation in phytoplankton. A kinetic-based model was used to predict congener-specific bioaccumulation factors of PCBs in phytoplankton samples collected from Green Bay, Lake Michigan. These values were compared to the measured bioaccumulation factors, and the sum of the residuals was used to evaluate the model`s predictive quality. The sorbing matrix fraction (F{sub M}) that minimized the sum of residuals of the model was then solved by iteration. The appropriateness of using dry weight, organic carbon fraction, or lipid fractions as the sorbing matrix fraction was determined by measuring their correlation to the optimum F{sub M}. It was determined that the F{sub M} correlated best with the organic carbon fraction, and this correlation appeared to be independent of both the spatial and seasonal differences of the field samples.

  12. Financial Distress Prediction Using Discrete-time Hazard Model and Rating Transition Matrix Approach

    NASA Astrophysics Data System (ADS)

    Tsai, Bi-Huei; Chang, Chih-Huei

    2009-08-01

    Previous studies used constant cut-off indicator to distinguish distressed firms from non-distressed ones in the one-stage prediction models. However, distressed cut-off indicator must shift according to economic prosperity, rather than remains fixed all the time. This study focuses on Taiwanese listed firms and develops financial distress prediction models based upon the two-stage method. First, this study employs the firm-specific financial ratio and market factors to measure the probability of financial distress based on the discrete-time hazard models. Second, this paper further focuses on macroeconomic factors and applies rating transition matrix approach to determine the distressed cut-off indicator. The prediction models are developed by using the training sample from 1987 to 2004, and their levels of accuracy are compared with the test sample from 2005 to 2007. As for the one-stage prediction model, the model in incorporation with macroeconomic factors does not perform better than that without macroeconomic factors. This suggests that the accuracy is not improved for one-stage models which pool the firm-specific and macroeconomic factors together. In regards to the two stage models, the negative credit cycle index implies the worse economic status during the test period, so the distressed cut-off point is adjusted to increase based on such negative credit cycle index. After the two-stage models employ such adjusted cut-off point to discriminate the distressed firms from non-distressed ones, their error of misclassification becomes lower than that of one-stage ones. The two-stage models presented in this paper have incremental usefulness in predicting financial distress.

  13. Pilot Study of the Efficacy of Extracellular Matrix Arterial Interposition Grafts in a Sheep (Ovis aries) Model

    DTIC Science & Technology

    2014-02-18

    extracellular matrix arterial interposition grafts in a sheep (Ovis aries) model." 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER...carotid arteries in sheep . Methods: Three crossbred sheep were anesthetized, instrumented, and had 10 cm interposition grafts placed in both carotid...was present by four weeks. Conclusion: In this pilot study, the Cormatrix extracellular matrix performed well in a sheep carotid interposition graft

  14. Relapse and Risk-taking among Iranian Methamphetamine Abusers Undergoing Matrix Treatment Model

    PubMed Central

    Taymoori, Parvaneh; Pashaei, Tahereh

    2016-01-01

    Background This study investigated the correlation between risk-taking and relapse among methamphetamine (MA) abusers undergoing the Matrix Model of treatment. Methods This cross-sectional study was conducted on male patients who were stimulant drug abusers undergoing the matrix treatment in the National Center for Addiction Research. A sampling was done using the availability method including 92 male patients. Demographic questionnaires and drug abuse related questionnaire were completed for each patient. Then, Bart’s balloon risk-taking test was administered to the patients. Findings Participants had a mean age ± standard deviation (SD) of 27.59 ± 6.60 years with an age range of 17-29 years. Unemployment, unmarried status, criminal offense, and also addiction family history increased the probability of relapse. In addition, a greater adjusted score of the risk-taking test increased the odds of relapse by more than 97%. The simultaneous abuse of opium and stimulants compared to the abuse of stimulants only, revealed no statistically significant differences for relapse. Patients with higher risk-taking behavior had a more probability of relapse. Conclusion This finding indirectly implies the usefulness of Bart’s risk-taking test in assessing risk-taking behavior in stimulant drug abusers. PMID:27274793

  15. Sparse modeling of EELS and EDX spectral imaging data by nonnegative matrix factorization.

    PubMed

    Shiga, Motoki; Tatsumi, Kazuyoshi; Muto, Shunsuke; Tsuda, Koji; Yamamoto, Yuta; Mori, Toshiyuki; Tanji, Takayoshi

    2016-11-01

    Advances in scanning transmission electron microscopy (STEM) techniques have enabled us to automatically obtain electron energy-loss (EELS)/energy-dispersive X-ray (EDX) spectral datasets from a specified region of interest (ROI) at an arbitrary step width, called spectral imaging (SI). Instead of manually identifying the potential constituent chemical components from the ROI and determining the chemical state of each spectral component from the SI data stored in a huge three-dimensional matrix, it is more effective and efficient to use a statistical approach for the automatic resolution and extraction of the underlying chemical components. Among many different statistical approaches, we adopt a non-negative matrix factorization (NMF) technique, mainly because of the natural assumption of non-negative values in the spectra and cardinalities of chemical components, which are always positive in actual data. This paper proposes a new NMF model with two penalty terms: (i) an automatic relevance determination (ARD) prior, which optimizes the number of components, and (ii) a soft orthogonal constraint, which clearly resolves each spectrum component. For the factorization, we further propose a fast optimization algorithm based on hierarchical alternating least-squares. Numerical experiments using both phantom and real STEM-EDX/EELS SI datasets demonstrate that the ARD prior successfully identifies the correct number of physically meaningful components. The soft orthogonal constraint is also shown to be effective, particularly for STEM-EELS SI data, where neither the spatial nor spectral entries in the matrices are sparse.

  16. T-Matrix Modeling of Linear Depolarization by Morphologically Complex Soot and Soot-Containing Aerosols

    NASA Technical Reports Server (NTRS)

    Mishchenko, Michael I.; Liu, Li; Mackowski, Daniel W.

    2013-01-01

    We use state-of-the-art public-domain Fortran codes based on the T-matrix method to calculate orientation and ensemble averaged scattering matrix elements for a variety of morphologically complex black carbon (BC) and BC-containing aerosol particles, with a special emphasis on the linear depolarization ratio (LDR). We explain theoretically the quasi-Rayleigh LDR peak at side-scattering angles typical of low-density soot fractals and conclude that the measurement of this feature enables one to evaluate the compactness state of BC clusters and trace the evolution of low-density fluffy fractals into densely packed aggregates. We show that small backscattering LDRs measured with groundbased, airborne, and spaceborne lidars for fresh smoke generally agree with the values predicted theoretically for fluffy BC fractals and densely packed near-spheroidal BC aggregates. To reproduce higher lidar LDRs observed for aged smoke, one needs alternative particle models such as shape mixtures of BC spheroids or cylinders.

  17. Facultative control of matrix production optimizes competitive fitness in Pseudomonas aeruginosa PA14 biofilm models.

    PubMed

    Madsen, Jonas S; Lin, Yu-Cheng; Squyres, Georgia R; Price-Whelan, Alexa; de Santiago Torio, Ana; Song, Angela; Cornell, William C; Sørensen, Søren J; Xavier, Joao B; Dietrich, Lars E P

    2015-12-01

    As biofilms grow, resident cells inevitably face the challenge of resource limitation. In the opportunistic pathogen Pseudomonas aeruginosa PA14, electron acceptor availability affects matrix production and, as a result, biofilm morphogenesis. The secreted matrix polysaccharide Pel is required for pellicle formation and for colony wrinkling, two activities that promote access to O2. We examined the exploitability and evolvability of Pel production at the air-liquid interface (during pellicle formation) and on solid surfaces (during colony formation). Although Pel contributes to the developmental response to electron acceptor limitation in both biofilm formation regimes, we found variation in the exploitability of its production and necessity for competitive fitness between the two systems. The wild type showed a competitive advantage against a non-Pel-producing mutant in pellicles but no advantage in colonies. Adaptation to the pellicle environment selected for mutants with a competitive advantage against the wild type in pellicles but also caused a severe disadvantage in colonies, even in wrinkled colony centers. Evolution in the colony center produced divergent phenotypes, while adaptation to the colony edge produced mutants with clear competitive advantages against the wild type in this O2-replete niche. In general, the structurally heterogeneous colony environment promoted more diversification than the more homogeneous pellicle. These results suggest that the role of Pel in community structure formation in response to electron acceptor limitation is unique to specific biofilm models and that the facultative control of Pel production is required for PA14 to maintain optimum benefit in different types of communities.

  18. Accounting for management costs in sensitivity analyses of matrix population models.

    PubMed

    Baxter, Peter W J; McCarthy, Michael A; Possingham, Hugh P; Menkhorst, Peter W; McLean, Natasha

    2006-06-01

    Traditional sensitivity and elasticity analyses of matrix population models have been used to inform management decisions, but they ignore the economic costs of manipulating vital rates. For example, the growth rate of a population is often most sensitive to changes in adult survival rate, but this does not mean that increasing that rate is the best option for managing the population because it may be much more expensive than other options. To explore how managers should optimize their manipulation of vital rates, we incorporated the cost of changing those rates into matrix population models. We derived analytic expressions for locations in parameter space where managers should shift between management of fecundity and survival, for the balance between fecundity and survival management at those boundaries, and for the allocation of management resources to sustain that optimal balance. For simple matrices, the optimal budget allocation can often be expressed as simple functions of vital rates and the relative costs of changing them. We applied our method to management of the Helmeted Honeyeater (Lichenostomus melanops cassidix; an endangered Australian bird) and the koala (Phascolarctos cinereus) as examples. Our method showed that cost-efficient management of the Helmeted Honeyeater should focus on increasing fecundity via nest protection, whereas optimal koala management should focus on manipulating both fecundity and survival simultaneously. These findings are contrary to the cost-negligent recommendations of elasticity analysis, which would suggest focusing on managing survival in both cases. A further investigation of Helmeted Honeyeater management options, based on an individual-based model incorporating density dependence, spatial structure, and environmental stochasticity, confirmed that fecundity management was the most cost-effective strategy. Our results demonstrate that decisions that ignore economic factors will reduce management efficiency.

  19. Discovery of potent inhibitor for matrix metalloproteinase-9 by pharmacophore based modeling and dynamics simulation studies.

    PubMed

    Kalva, Sukesh; Azhagiya Singam, E R; Rajapandian, V; Saleena, Lilly M; Subramanian, V

    2014-04-01

    Matrix metalloproteinase-9 (MMP-9) is an attractive target for anticancer therapy. In the present study ligand based pharmacophore modeling was performed to elucidate the structural elements for a diverse class of MMP-9 inhibitors. The pharmacophore model was validated through Güner-Henry (GH) scoring method. The final pharmacophore model consisted of three hydrogen bond acceptors (HBA), and two ring aromatic regions (RA). This model was utilized to screen the natural compound database to seek novel compounds as MMP-9 inhibitors. The identified hits were validated using molecular docking and molecular dynamics simulation studies. Finally, one compound named Hinokiflavone from Juniperus communis had high binding free energy of -26.54kJ/mol compared with the known inhibitors of MMP-9. Cytotoxicity for hinokiflavone was evaluated by MTT assay. Inhibition of MMP-9 in the presence of hinokiflavone was detected by gelatin zymography and gelatinolytic inhibition assay. Results revealed that the natural compounds derived based on the developed pharmacophore model would be useful for further design and development of MMP-9 inhibitors.

  20. Convection equation modeling: A non-iterative direct matrix solution algorithm for use with SINDA

    NASA Technical Reports Server (NTRS)

    Schrage, Dean S.

    1993-01-01

    The determination of the boundary conditions for a component-level analysis, applying discrete finite element and finite difference modeling techniques often requires an analysis of complex coupled phenomenon that cannot be described algebraically. For example, an analysis of the temperature field of a coldplate surface with an integral fluid loop requires a solution to the parabolic heat equation and also requires the boundary conditions that describe the local fluid temperature. However, the local fluid temperature is described by a convection equation that can only be solved with the knowledge of the locally-coupled coldplate temperatures. Generally speaking, it is not computationally efficient, and sometimes, not even possible to perform a direct, coupled phenomenon analysis of the component-level and boundary condition models within a single analysis code. An alternative is to perform a disjoint analysis, but transmit the necessary information between models during the simulation to provide an indirect coupling. For this approach to be effective, the component-level model retains full detail while the boundary condition model is simplified to provide a fast, first-order prediction of the phenomenon in question. Specifically for the present study, the coldplate structure is analyzed with a discrete, numerical model (SINDA) while the fluid loop convection equation is analyzed with a discrete, analytical model (direct matrix solution). This indirect coupling allows a satisfactory prediction of the boundary condition, while not subjugating the overall computational efficiency of the component-level analysis. In the present study a discussion of the complete analysis of the derivation and direct matrix solution algorithm of the convection equation is presented. Discretization is analyzed and discussed to extend of solution accuracy, stability and computation speed. Case studies considering a pulsed and harmonic inlet disturbance to the fluid loop are analyzed to

  1. Evaluation of Johnson-Cook model constants for aluminum based particulate metal matrix composites

    NASA Astrophysics Data System (ADS)

    Hilfi, H.; Brar, N. S.

    1996-05-01

    High strain rate and high temperature response of three types of aluminum based particulate metal matrix ceramic composites is investigated by performing split Hopkinson pressure bar (SHPB) experiments. The composites are: NGP-2014 (15% SiC), NGT-6061 (15% SiC), and NGU-6061 (15% Al2O3), in which all the reinforcement materials are percentage by volume. Johnson-Cook constitutive model constants are evaluated from the high strain rate/high temperature data and implemented in a two dimensional finite element computer code (EPIC-2D) to simulate the penetration of an ogive nose tungsten projectile (23 grams) at a velocity 1.17 km/sec into the base 6061-T6 aluminum alloy and the composite NGU-6061. The simulated penetrations in the composite and in 6061-T6 aluminum agree with in 2%, in both materials, with the measured values.

  2. Spacetime Emergence of the Robertson-Walker Universe from a Matrix Model

    SciTech Connect

    Erdmenger, Johanna; Meyer, Rene; Park, Jeong-Hyuck

    2007-06-29

    Using a novel, string theory-inspired formalism based on a Hamiltonian constraint, we obtain a conformal mechanical system for the spatially flat four-dimensional Robertson-Walker Universe. Depending on parameter choices, this system describes either a relativistic particle in the Robertson-Walker background or metric fluctuations of the Robertson-Walker geometry. Moreover, we derive a tree-level M theory matrix model in this time-dependent background. Imposing the Hamiltonian constraint forces the spacetime geometry to be fuzzy near the big bang, while the classical Robertson-Walker geometry emerges as the Universe expands. From our approach, we also derive the temperature of the Universe interpolating between the radiation and matter dominated eras.

  3. Spacetime emergence of the robertson-walker universe from a matrix model.

    PubMed

    Erdmenger, Johanna; Meyer, René; Park, Jeong-Hyuck

    2007-06-29

    Using a novel, string theory-inspired formalism based on a Hamiltonian constraint, we obtain a conformal mechanical system for the spatially flat four-dimensional Robertson-Walker Universe. Depending on parameter choices, this system describes either a relativistic particle in the Robertson-Walker background or metric fluctuations of the Robertson-Walker geometry. Moreover, we derive a tree-level M theory matrix model in this time-dependent background. Imposing the Hamiltonian constraint forces the spacetime geometry to be fuzzy near the big bang, while the classical Robertson-Walker geometry emerges as the Universe expands. From our approach, we also derive the temperature of the Universe interpolating between the radiation and matter dominated eras.

  4. Aberrant alternative splicing and extracellular matrix gene expression in mouse models of myotonic dystrophy

    PubMed Central

    Du, Hongqing; Cline, Melissa S.; Osborne, Robert J.; Tuttle, Daniel L.; Clark, Tyson A.; Donohue, John Paul; Hall, Megan P.; Shiue, Lily; Swanson, Maurice S.; Thornton, Charles A.; Ares, Manuel

    2009-01-01

    Myotonic dystrophy (DM1) is associated with expression of expanded CTG DNA repeats as RNA (CUGexp RNA). To test whether CUGexp RNA creates a global splicing defect, we compared skeletal muscle of two mouse DM1 models, one expressing a CTGexp transgene, and another homozygous for a defective Mbnl1 gene. Strong correlation in splicing changes for ~100 new Mbnl1-regulated exons indicates loss of Mbnl1 explains >80% of the splicing pathology due to CUGexp RNA. In contrast, only about half of mRNA level changes can be attributed to loss of Mbnl1, indicating CUGexp RNA has Mbnl1-independent effects, particularly on mRNAs for extracellular matrix (ECM) proteins. We propose that CUGexp RNA causes two separate effects: loss of Mbnl1 function, disrupting splicing, and loss of another function that disrupts ECM mRNA regulation, possibly mediated by MBNL2. These findings reveal unanticipated similarities between DM1 and other muscular dystrophies. PMID:20098426

  5. Matrix models for supersymmetric Chern-Simons theories with an ADE classification

    NASA Astrophysics Data System (ADS)

    Gulotta, Daniel R.; Ang, J. P.; Herzog, Christopher P.

    2012-01-01

    We consider mathcal{N} = 3 supersymmetric Chern-Simons (CS) theories that contain product U(N ) gauge groups and bifundamental matter fields. Using the matrix model of Kapustin, Willett and Yaakov, we examine the Euclidean partition function of these theories on an S 3 in the large N limit. We show that the only such CS theories for which the long range forces between the eigenvalues cancel have quivers which are in one-to-one correspondence with the simply laced affine Dynkin diagrams. As the A n series was studied in detail before, in this paper we compute the partition function for the D 4 quiver. The D 4 example gives further evidence for a conjecture that the saddle point eigenvalue distribution is determined by the distribution of gauge invariant chiral operators. We also see that the partition function is invariant under a generalized Seiberg duality for CS theories.

  6. Density matrix model for polarons in a terahertz quantum dot cascade laser

    NASA Astrophysics Data System (ADS)

    Burnett, Benjamin A.; Williams, Benjamin S.

    2014-10-01

    A density matrix based method is introduced for computation of steady-state dynamics in quantum cascade systems of arbitrary size, which incorporates an optical field coherently. The method is applied to a model terahertz quantum dot cascade laser system, where a means of treating coherent electron-optical-phonon coupling is also introduced. Results predict a strong increase in the upper state lifetime and operating temperature as compared to traditional well-based terahertz quantum cascade lasers. However, new complications also arise, including multiple peaks in the gain spectrum due to strong electron-phonon coupling, and strong parasitic subthreshold current channels that arise due to reduced dephasing. It is anticipated that novel design schemes will be necessary for such lasers to become a reality.

  7. Interfacial shear stress distribution in model composites. I - A Kevlar 49 fibre in an epoxy matrix

    SciTech Connect

    Jahankhani, H.; Galiotis, C. )

    1991-05-01

    The technique of Laser Raman Spectroscopy has been applied in the study of aramid fibers, such as Kevlar 49, and aramid/epoxy interfaces. A linear relationship has been found between Raman frequencies and strain upon loading a single Kevlar 49 filament in air. Model composites of single Kevlar 49 fibers embedded in epoxy resins have been fabricated and subjected to various degrees of mechanical deformation. The transfer lengths for reinforcement have been measured at various levels of applied tensile load and the dependence of transfer length upon applied matrix strain has been established. Finally, by balancing the tensile and the shear forces acting along the interface, the interfacial shear stress (ISS) distribution along the embedded fiber was obtained. 52 refs.

  8. Numerical Computation of a Continuous-thrust State Transition Matrix Incorporating Accurate Hardware and Ephemeris Models

    NASA Technical Reports Server (NTRS)

    Ellison, Donald; Conway, Bruce; Englander, Jacob

    2015-01-01

    A significant body of work exists showing that providing a nonlinear programming (NLP) solver with expressions for the problem constraint gradient substantially increases the speed of program execution and can also improve the robustness of convergence, especially for local optimizers. Calculation of these derivatives is often accomplished through the computation of spacecraft's state transition matrix (STM). If the two-body gravitational model is employed as is often done in the context of preliminary design, closed form expressions for these derivatives may be provided. If a high fidelity dynamics model, that might include perturbing forces such as the gravitational effect from multiple third bodies and solar radiation pressure is used then these STM's must be computed numerically. We present a method for the power hardward model and a full ephemeris model. An adaptive-step embedded eight order Dormand-Prince numerical integrator is discussed and a method for the computation of the time of flight derivatives in this framework is presented. The use of these numerically calculated derivatieves offer a substantial improvement over finite differencing in the context of a global optimizer. Specifically the inclusion of these STM's into the low thrust missiondesign tool chain in use at NASA Goddard Spaceflight Center allows for an increased preliminary mission design cadence.

  9. Density matrix renormalization group study of the Anyon-Hubbard model

    NASA Astrophysics Data System (ADS)

    Arcila-Forero, J.; Franco, R.; Silva-Valencia, J.

    2016-02-01

    Recently optical lattices allow us to observe phase transition without the uncertainty posed by complex materials, and the simulations of these systems are an excellent bridge between materials-based condensed matter physics and cold atoms. In this way, the computational physics related to many-body problems have increased in importance. Using the density matrix renormalization group method, we studied a Hubbard model for anyons, which is an equivalent to a variant of the Bose-Hubbard model in which the bosonic hopping depends on the local density. This is an exact mapping between anyons and bosons in one dimension. The anyons interlope between bosons and fermions. For two anyons under particle exchange, the wave function acquires a fractional phase eiθ . We conclude that this system exhibits two phases: Mott-insulator and superfluid. We present the phase diagram for some angles. The Mott lobe increases with an increase of the statistical. We observed a reentrance phase transition for all lobes. We showed that the model studied is in the same universality class as the Bose-Hubbard model with two-body interactions.

  10. A transverse isotropic model for microporous solids: Application to coal matrix adsorption and swelling

    NASA Astrophysics Data System (ADS)

    Espinoza, D. N.; Vandamme, M.; Dangla, P.; Pereira, J.-M.; Vidal-Gilbert, S.

    2013-12-01

    Understanding the adsorption-induced swelling in coal is critical for predictable and enhanced coal bed methane production. The coal matrix is a natural anisotropic disordered microporous solid. We develop an elastic transverse isotropic poromechanical model for microporous solids which couples adsorption and strain through adsorption stress functions and expresses the adsorption isotherm as a multivariate function depending on fluid pressure and solid strains. Experimental data from the literature help invert the anisotropic adsorptive-mechanical properties of Brzeszcze coal samples exposed to CO2. The main findings include the following: (1) adsorption-induced swelling can be modeled by including fluid-specific and pressure-dependent adsorption stress functions into equilibrium equations, (2) modeling results suggest that swelling anisotropy is mostly caused by anisotropy of the solid mechanical properties, and (3) the total amount of adsorbed gas measured by immersing coal in the adsorbate overestimates adsorption amount compared to in situ conditions up to ˜20%. The developed fully coupled model can be upscaled to determine the coal seam permeability through permeability-stress relationships.

  11. The Effects of Q-Matrix Misspecification on Parameter Estimates and Classification Accuracy in the DINA Model

    ERIC Educational Resources Information Center

    Rupp, Andre A.; Templin, Jonathan

    2008-01-01

    This article reports a study that investigated the effects of Q-matrix misspecifications on parameter estimates and misclassification rates for the deterministic-input, noisy "and" gate (DINA) model, which is a restricted latent class model for multiple classifications of respondents that can be useful for cognitively motivated diagnostic…

  12. An open-access modeled passenger flow matrix for the global air network in 2010.

    PubMed

    Huang, Zhuojie; Wu, Xiao; Garcia, Andres J; Fik, Timothy J; Tatem, Andrew J

    2013-01-01

    The expanding global air network provides rapid and wide-reaching connections accelerating both domestic and international travel. To understand human movement patterns on the network and their socioeconomic, environmental and epidemiological implications, information on passenger flow is required. However, comprehensive data on global passenger flow remain difficult and expensive to obtain, prompting researchers to rely on scheduled flight seat capacity data or simple models of flow. This study describes the construction of an open-access modeled passenger flow matrix for all airports with a host city-population of more than 100,000 and within two transfers of air travel from various publicly available air travel datasets. Data on network characteristics, city population, and local area GDP amongst others are utilized as covariates in a spatial interaction framework to predict the air transportation flows between airports. Training datasets based on information from various transportation organizations in the United States, Canada and the European Union were assembled. A log-linear model controlling the random effects on origin, destination and the airport hierarchy was then built to predict passenger flows on the network, and compared to the results produced using previously published models. Validation analyses showed that the model presented here produced improved predictive power and accuracy compared to previously published models, yielding the highest successful prediction rate at the global scale. Based on this model, passenger flows between 1,491 airports on 644,406 unique routes were estimated in the prediction dataset. The airport node characteristics and estimated passenger flows are freely available as part of the Vector-Borne Disease Airline Importation Risk (VBD-Air) project at: www.vbd-air.com/data.

  13. An Open-Access Modeled Passenger Flow Matrix for the Global Air Network in 2010

    PubMed Central

    Huang, Zhuojie; Wu, Xiao; Garcia, Andres J.; Fik, Timothy J.; Tatem, Andrew J.

    2013-01-01

    The expanding global air network provides rapid and wide-reaching connections accelerating both domestic and international travel. To understand human movement patterns on the network and their socioeconomic, environmental and epidemiological implications, information on passenger flow is required. However, comprehensive data on global passenger flow remain difficult and expensive to obtain, prompting researchers to rely on scheduled flight seat capacity data or simple models of flow. This study describes the construction of an open-access modeled passenger flow matrix for all airports with a host city-population of more than 100,000 and within two transfers of air travel from various publicly available air travel datasets. Data on network characteristics, city population, and local area GDP amongst others are utilized as covariates in a spatial interaction framework to predict the air transportation flows between airports. Training datasets based on information from various transportation organizations in the United States, Canada and the European Union were assembled. A log-linear model controlling the random effects on origin, destination and the airport hierarchy was then built to predict passenger flows on the network, and compared to the results produced using previously published models. Validation analyses showed that the model presented here produced improved predictive power and accuracy compared to previously published models, yielding the highest successful prediction rate at the global scale. Based on this model, passenger flows between 1,491 airports on 644,406 unique routes were estimated in the prediction dataset. The airport node characteristics and estimated passenger flows are freely available as part of the Vector-Borne Disease Airline Importation Risk (VBD-Air) project at: www.vbd-air.com/data. PMID:23691194

  14. Constrained positive matrix factorization: Elemental ratios, spatial distinction, and chemical transport model source contributions

    NASA Astrophysics Data System (ADS)

    Sturtz, Timothy M.

    Source apportionment models attempt to untangle the relationship between pollution sources and the impacts at downwind receptors. Two frameworks of source apportionment models exist: source-oriented and receptor-oriented. Source based apportionment models use presumed emissions and atmospheric processes to estimate the downwind source contributions. Conversely, receptor based models leverage speciated concentration data from downwind receptors and apply statistical methods to predict source contributions. Integration of both source-oriented and receptor-oriented models could lead to a better understanding of the implications sources have on the environment and society. The research presented here investigated three different types of constraints applied to the Positive Matrix Factorization (PMF) receptor model within the framework of the Multilinear Engine (ME-2): element ratio constraints, spatial separation constraints, and chemical transport model (CTM) source attribution constraints. PM10-2.5 mass and trace element concentrations were measured in Winston-Salem, Chicago, and St. Paul at up to 60 sites per city during two different seasons in 2010. PMF was used to explore the underlying sources of variability. Information on previously reported PM10-2.5 tire and brake wear profiles were used to constrain these features in PMF by prior specification of selected species ratios. We also modified PMF to allow for combining the measurements from all three cities into a single model while preserving city-specific soil features. Relatively minor differences were observed between model predictions with and without the prior ratio constraints, increasing confidence in our ability to identify separate brake wear and tire wear features. Using separate data, source contributions to total fine particle carbon predicted by a CTM were incorporated into the PMF receptor model to form a receptor-oriented hybrid model. The level of influence of the CTM versus traditional PMF was

  15. An iterative parallel sparse matrix equation solver with application to finite element modeling of electromagnetic scattering

    SciTech Connect

    Cwik, T.; Jamnejad, V.; Zuffada, C.

    1994-12-31

    The usefulness of finite element modeling follows from the ability to accurately simulate the geometry and three-dimensional fields on the scale of a fraction of a wavelength. To make this modeling practical for engineering design, it is necessary to integrate the stages of geometry modeling and mesh generation, numerical solution of the fields-a stage heavily dependent on the efficient use of a sparse matrix equation solver, and display of field information. The stages of geometry modeling, mesh generation, and field display are commonly completed using commercially available software packages. Algorithms for the numerical solution of the fields need to be written for the specific class of problems considered. Interior problems, i.e. simulating fields in waveguides and cavities, have been successfully solved using finite element methods. Exterior problems, i.e. simulating fields scattered or radiated from structures, are more difficult to model because of the need to numerically truncate the finite element mesh. To practically compute a solution to exterior problems, the domain must be truncated at some finite surface where the Sommerfeld radiation condition is enforced, either approximately or exactly. Approximate methods attempt to truncate the mesh using only local field information at each grid point, whereas exact methods are global, needing information from the entire mesh boundary. In this work, a method that couples three-dimensional finite element (FE) solutions interior to the bounding surface, with an efficient integral equation (IE) solution that exactly enforces the Sommerfeld radiation condition is developed. The bounding surface is taken to be a surface of revolution (SOR) to greatly reduce computational expense in the IE portion of the modeling.

  16. Fluid-matrix interactions during high-temperature aquifer storage - lab experiments and modelling

    NASA Astrophysics Data System (ADS)

    Wismeth, Carina; Ueckert, Martina; Muffler, Selina; Niessner, Reinhard; Baumann, Thomas

    2016-04-01

    High-temperature aquifer storage is a promising extension to combined heat and power plants because it allows to store excess heat during the summer months and to recuperate the heat in winter when the heat demand exceeds the production. Within a research project funded by the Bavarian State Ministry for Economic Affairs and Media, Energy and Technology and the BMW Group, a pilot scale test was run at the Dingolfing site (Bavaria, Germany) in 2014. Field data and an a priori numerical model suggest dissolution and precipitation of the processes in the calcareous aquifer. In order to quantify the reaction kinetics, lab experiments were run in an autoclave. The experimental results were used to setup and calibrate a numerical hydrogeochemical model based on PhreeqC. Laboratory experiments were performed in a closed system with respect to CO2 and under pre-defined conditions using a high temperature autoclave. Within the dissolution test series original core samples of different depth were heated up with ultrapure water in defined heating cycles up to 110 °C and at defined pressure. For combined dissolution and precipitation processes, tap water from Munich was used. The gas phase was equilibrated with CO2 regarding the pCO2 of tap water. Five water samples were taken for each heating cycle and analyzed by ion chromatography to quantify the calcium/magnesium concentrations and ratio. Additionally the sorption properties of the core materials were tested with respect to the fluorescent dyes used in the field tests. The starting point to model the fluid matrix interactions was literature data of dolomite and calcite rates, which were integrated in the conceptional model. While the model results matched the experimentally determined concentrations nicely, there was a discrepancy with respect to the effective surface areas, which is likely due to impurities of the natural rock materials. The model was able to describe the minor precipitation of calcite during the

  17. Comprehensive analysis of leukocytes, vascularization and matrix metalloproteinases in human menstrual xenograft model.

    PubMed

    Guo, Yong; He, Bin; Xu, Xiangbo; Wang, Jiedong

    2011-02-17

    In our previous study, menstrual-like changes in mouse were provoked through the pharmacologic withdrawal of progesterone with mifepristone following induction of decidualization. However, mouse is not a natural menstruation animal, and the menstruation model using external stimuli may not truly reflect the occurrence and development of the human menstrual process. Therefore, we established a model of menstruation based on human endometrial xenotransplantation. In this model, human endometrial tissues were transplanted subcutaneously into SCID mice that were ovarectomized and supplemented with estrogen and progestogen by silastic implants with a scheme imitating the endocrinological milieu of human menstrual cycle. Morphology, hormone levels, and expression of vimentin and cytokeratin markers were evaluated to confirm the menstrual-like changes in this model. With 28 days of hormone treatment, transplanted human endometrium survived and underwent proliferation, differentiation and disintegration, similar to human endometrium in vivo. Human CD45+ cells showed a peak of increase 28 days post-transplantation. Three days after progesterone withdrawal, mouse CD45+ cells increased rapidly in number and were significantly greater than human CD45+ cell counts. Mouse CD31+ blood vascular-like structures were detected in both transplanted and host tissues. After progesterone withdrawal, the expression levels of matrix metalloproteinases (MMP) 1, 2, and 9 were increased. In summary, we successfully established a human endometrial xenotransplantation model in SCID mice, based on the results of menstrual-like changes in which MMP-1, 2 and 9 are involved. We showed that leukocytes are originated from in situ proliferation in human xenografts and involved in the occurrence of menstruation. This model will help to further understand the occurrence, growth, and differentiation of the endometrium and the underlying mechanisms of menstruation.

  18. Decellularized skeletal muscle as an in vitro model for studying drug-extracellular matrix interactions

    PubMed Central

    Wassenaar, Jean W.; Boss, Gerry R.; Christman, Karen L.

    2015-01-01

    Several factors can affect drug absorption after intramuscular (IM) injection: drug solubility, drug transport across cell membranes, and drug metabolism at the injection site. We found that potential interactions between the drug and the extracellular matrix (ECM) at the injection site can also affect the rate of absorption post-injection. Using decellularized skeletal muscle, we developed a simple method to model drug absorption after IM injection, and showed that the nature of the drug-ECM interaction could be investigated by adding compounds that alter binding. We validated the model using the vitamin B12 analog cobinamide with different bound ligands. Cobinamide is being developed as an IM injectable treatment for cyanide poisoning, and we found that the in vitro binding data correlated with previously published in vivo drug absorption in animals. Commercially available ECM products, such as collagen and GelTrex, did not recapitulate drug binding behavior. While decellularized ECM has been widely studied in fields such as tissue engineering, this work establishes a novel use of skeletal muscle ECM as a potential in vitro model to study drug-ECM interactions during drug development. PMID:26125502

  19. Mathematical Modeling of Particle Segregation During Centrifugal Casting of Metal Matrix Composites

    NASA Astrophysics Data System (ADS)

    Balout, B.; Litwin, J.

    2012-04-01

    When a metal matrix composite undergoes centrifugal casting, the velocity, deceleration, displacement, and segregation of its particles are modeled according to changes in the centrifugal radius, as well as by variations in the molten metal viscosity as the temperature decreases during the cooling process. A cast aluminum alloy A356 reinforced by 10 V% of silicon carbide particles (SiC), with a median diameter of 12 μm, was used to conduct the experiments, and a mathematical modeling showed that the particles' volume fraction on the outer casting face varied according to whether the viscosity of the liquid metal used was constant or variable. If variations in viscosity during the cooling process are taken into account, then the volume fraction of the particles for a given time of centrifugation changes on the outer casting face, while it increases if the viscosity was constant. Modeling the particle segregation with variable viscosity produces results that are closer to those obtained with experiments than is the case when a constant viscosity is used. In fact, the higher the initial pouring and mold temperatures, the higher the effect of the viscosity variation on particle segregation.

  20. Thimble regularization at work: From toy models to chiral random matrix theories

    NASA Astrophysics Data System (ADS)

    Di Renzo, F.; Eruzzi, G.

    2015-10-01

    We apply the Lefschetz thimble formulation of field theories to a couple of different problems. We first address the solution of a complex zero-dimensional ϕ4 theory. Although very simple, this toy model makes us appreciate a few key issues of the method. In particular, we will solve the model by a correct accounting of all the thimbles giving a contribution to the partition function and we will discuss a number of algorithmic solutions to simulate this (simple) model. We will then move to a chiral random matrix (CRM) theory. This is a somehow more realistic setting, giving us once again the chance to tackle the same couple of fundamental questions: How many thimbles contribute to the solution? How can we make sure that we correctly sample configurations on the thimble? Since the exact result is known for the observable we study (a condensate), we can verify that, in the region of parameters we studied, only one thimble contributes and that the algorithmic solution that we set up works well, despite its very crude nature. The deviation of results from phase quenched ones highlights that in a certain region of parameter space there is a quite important sign problem. In view of this, the success of our thimble approach is quite a significant one.

  1. Oxidation of Carbon Fibers in a Cracked Ceramic Matrix Composite Modeled as a Function of Temperature

    NASA Technical Reports Server (NTRS)

    Halbig, Michael C.; Cawley, James D.; Eckel, Andrew J.

    2003-01-01

    The oxidation model simulates the oxidation of the reinforcing carbon fibers within a ceramic matrix composite material containing as-fabricated microcracks. The physics-based oxidation model uses theoretically and experimentally determined variables as input for the model. The model simulates the ingress of oxygen through microcracks into a two-dimensional plane within the composite material. Model input includes temperature, oxygen concentration, the reaction rate constant, the diffusion coefficient, and the crack opening width as a function of the mechanical and thermal loads. The model is run in an iterative process for a two-dimensional grid system in which oxygen diffuses through the porous and cracked regions of the material and reacts with carbon in short time steps. The model allows the local oxygen concentrations and carbon volumes from the edge to the interior of the composite to be determined over time. Oxidation damage predicted by the model was compared with that observed from microstructural analysis of experimentally tested composite material to validate the model for two temperatures of interest. When the model is run for low-temperature conditions, the kinetics are reaction controlled. Carbon and oxygen reactions occur relatively slowly. Therefore, oxygen can bypass the carbon near the outer edge and diffuse into the interior so that it saturates the entire composite at relatively high concentrations. The kinetics are limited by the reaction rate between carbon and oxygen. This results in an interior that has high local concentrations of oxygen and a similar amount of consumed carbon throughout the cross section. When the model is run for high-temperature conditions, the kinetics are diffusion controlled. Carbon and oxygen reactions occur very quickly. The carbon consumes oxygen as soon as it is supplied. The kinetics are limited by the relatively slow rate at which oxygen is supplied in comparison to the relatively fast rate at which carbon and

  2. A fiber matrix model for fluid flow and streaming potentials in the canaliculi of an osteon

    NASA Technical Reports Server (NTRS)

    Zeng, Y.; Cowin, S. C.; Weinbaum, S.

    1994-01-01

    A theoretical model is developed to predict the fluid shear stress and streaming potential at the surface of osteocytic processes in the lacunar-canalicular porosity of an osteon when the osteon is subject to mechanical loads that are parallel or perpendicular to its axis. The theory developed in Weinbaum et al. (31) for the flow through a proteoglycan matrix in a canaliculus is employed in a poroelastic model for the osteon. Our formulation is a generalization of that of Petrov et al. (17). Our model predicts that, in order to satisfy the measured frequency dependence of the phase and magnitude of the SGP in macroscopic bone samples, the fiber spacing in the fluid annulus must lie in the narrow range 6-7 nm typical of the spacing of GAG sidechains along a protein monomer. The model predictions for the local SGP profiles in the osteon agree with the experimental observations of Starkebaum et al. (24). The theory predicts that the pore pressure relaxation time, tau d, for a 150-300 microns diameter osteon with the foregoing matrix structure is approximately 0.03-0.13 sec, and that the amplitude of the mean fluid shear stress on the membrane of the osteocytic process at the mean areal radius of the osteon has a maximum at 28 Hz if tau d = 0.06 sec. This maximum, which is independent of the magnitude of the loading, could be important in vivo since the recent experiments of Turner et al. (28) and McLeod et al. (15) have a peak in the strain frequency spectrum between 20 and 30 Hz that also appears to be independent of the type (magnitude) of loading. Numerical predictions for the amplitude of the average fluid shear stress on the osteocytic membrane at the mean areal radius of the osteon show that the fluid shear stress associated with the low amplitude 20-30 Hz spectral strain component is at least as large as the average fluid shear stress associated with the high amplitude 1 Hz stride component, although the latter loading is an order of magnitude larger, and has a

  3. Modeling extracellular matrix (ECM) alterations in ovarian cancer by multiphoton excited fabrication of stromal models (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Campagnola, Paul J.; Ajeti, Visar; Lara, Jorge; Eliceiri, Kevin W.; Patankar, Mansh

    2016-04-01

    A profound remodeling of the extracellular matrix (ECM) occurs in human ovarian cancer but it unknown how this affects tumor growth, where this understanding could lead to better diagnostics and therapeutic approaches. We investigate the role of these ECM alterations by using multiphoton excited (MPE) polymerization to fabricate biomimetic models to investigate operative cell-matrix interactions in invasion/metastasis. First, we create nano/microstructured gradients mimicking the basal lamina to study adhesion/migration dynamics of ovarian cancer cells of differing metastatic potential. We find a strong haptotactic response that depends on both contact guidance and ECM binding cues. While we found enhanced migration for more invasive cells, the specifics of alignment and directed migration also depend on cell polarity. We further use MPE fabrication to create collagen scaffolds with complex, 3D submicron morphology. The stromal scaffold designs are derived directly from "blueprints" based on SHG images of normal, high risk, and malignant ovarian tissues. The models are seeded with different cancer cell lines and this allows decoupling of the roles of cell characteristics (metastatic potential) and ECM structure and composition (normal vs cancer) on adhesion/migration dynamics. We found the malignant stroma structure promotes enhanced migration and proliferation and also cytoskeletal alignment. Creating synthetic models based on fibers patterns further allows decoupling the topographic roles of the fibers themselves vs their alignment within the tissue. These models cannot be synthesized by other conventional fabrication methods and we suggest the MPE image-based fabrication method will enable a variety of studies in cancer biology.

  4. Facultative Control of Matrix Production Optimizes Competitive Fitness in Pseudomonas aeruginosa PA14 Biofilm Models

    PubMed Central

    Madsen, Jonas S.; Lin, Yu-Cheng; Squyres, Georgia R.; Price-Whelan, Alexa; de Santiago Torio, Ana; Song, Angela; Cornell, William C.; Sørensen, Søren J.

    2015-01-01

    As biofilms grow, resident cells inevitably face the challenge of resource limitation. In the opportunistic pathogen Pseudomonas aeruginosa PA14, electron acceptor availability affects matrix production and, as a result, biofilm morphogenesis. The secreted matrix polysaccharide Pel is required for pellicle formation and for colony wrinkling, two activities that promote access to O2. We examined the exploitability and evolvability of Pel production at the air-liquid interface (during pellicle formation) and on solid surfaces (during colony formation). Although Pel contributes to the developmental response to electron acceptor limitation in both biofilm formation regimes, we found variation in the exploitability of its production and necessity for competitive fitness between the two systems. The wild type showed a competitive advantage against a non-Pel-producing mutant in pellicles but no advantage in colonies. Adaptation to the pellicle environment selected for mutants with a competitive advantage against the wild type in pellicles but also caused a severe disadvantage in colonies, even in wrinkled colony centers. Evolution in the colony center produced divergent phenotypes, while adaptation to the colony edge produced mutants with clear competitive advantages against the wild type in this O2-replete niche. In general, the structurally heterogeneous colony environment promoted more diversification than the more homogeneous pellicle. These results suggest that the role of Pel in community structure formation in response to electron acceptor limitation is unique to specific biofilm models and that the facultative control of Pel production is required for PA14 to maintain optimum benefit in different types of communities. PMID:26431965

  5. An Investigation of Reliability Models for Ceramic Matrix Composites and their Implementation into Finite Element Codes

    NASA Technical Reports Server (NTRS)

    Duffy, Stephen F.

    1998-01-01

    The development of modeling approaches for the failure analysis of ceramic-based material systems used in high temperature environments was the primary objective of this research effort. These materials have the potential to support many key engineering technologies related to the design of aeropropulsion systems. Monolithic ceramics exhibit a number of useful properties such as retention of strength at high temperatures, chemical inertness, and low density. However, the use of monolithic ceramics has been limited by their inherent brittleness and a large variation in strength. This behavior has motivated material scientists to reinforce the monolithic material with a ceramic fiber. The addition of a second ceramic phase with an optimized interface increases toughness and marginally increases strength. The primary purpose of the fiber is to arrest crack growth, not to increase strength. The material systems of interest in this research effort were laminated ceramic matrix composites, as well as two- and three- dimensional fabric reinforced ceramic composites. These emerging composite systems can compete with metals in many demanding applications. However, the ongoing metamorphosis of ceramic composite material systems, and the lack of standardized design data has in the past tended to minimize research efforts related to structural analysis. Many structural components fabricated from ceramic matrix composites (CMC) have been designed by "trial and error." The justification for this approach lies in the fact that during the initial developmental phases for a material system fabrication issues are paramount. Emphasis is placed on demonstrating feasibility rather than fully understanding the processes controlling mechanical behavior. This is understandable during periods of rapid improvements in material properties for any composite system. But to avoid the ad hoc approach, the analytical methods developed under this effort can be used to develop rational structural

  6. Anomalous NMR relaxation in cartilage matrix components and native cartilage: fractional-order models.

    PubMed

    Magin, Richard L; Li, Weiguo; Pilar Velasco, M; Trujillo, Juan; Reiter, David A; Morgenstern, Ashley; Spencer, Richard G

    2011-06-01

    We present a fractional-order extension of the Bloch equations to describe anomalous NMR relaxation phenomena (T(1) and T(2)). The model has solutions in the form of Mittag-Leffler and stretched exponential functions that generalize conventional exponential relaxation. Such functions have been shown by others to be useful for describing dielectric and viscoelastic relaxation in complex, heterogeneous materials. Here, we apply these fractional-order T(1) and T(2) relaxation models to experiments performed at 9.4 and 11.7 Tesla on type I collagen gels, chondroitin sulfate mixtures, and to bovine nasal cartilage (BNC), a largely isotropic and homogeneous form of cartilage. The results show that the fractional-order analysis captures important features of NMR relaxation that are typically described by multi-exponential decay models. We find that the T(2) relaxation of BNC can be described in a unique way by a single fractional-order parameter (α), in contrast to the lack of uniqueness of multi-exponential fits in the realistic setting of a finite signal-to-noise ratio. No anomalous behavior of T(1) was observed in BNC. In the single-component gels, for T(2) measurements, increasing the concentration of the largest components of cartilage matrix, collagen and chondroitin sulfate, results in a decrease in α, reflecting a more restricted aqueous environment. The quality of the curve fits obtained using Mittag-Leffler and stretched exponential functions are in some cases superior to those obtained using mono- and bi-exponential models. In both gels and BNC, α appears to account for micro-structural complexity in the setting of an altered distribution of relaxation times. This work suggests the utility of fractional-order models to describe T(2) NMR relaxation processes in biological tissues.

  7. Anomalous NMR Relaxation in Cartilage Matrix Components and Native Cartilage: Fractional-Order Models

    PubMed Central

    Magin, Richard L.; Li, Weiguo; Velasco, M. Pilar; Trujillo, Juan; Reiter, David A.; Morgenstern, Ashley; Spencer, Richard G.

    2011-01-01

    We present a fractional-order extension of the Bloch equations to describe anomalous NMR relaxation phenomena (T1 and T2). The model has solutions in the form of Mittag-Leffler and stretched exponential functions that generalize conventional exponential relaxation. Such functions have been shown by others to be useful for describing dielectric and viscoelastic relaxation in complex, heterogeneous materials. Here, we apply these fractional-order T1 and T2 relaxation models to experiments performed at 9.4 and 11.7 Tesla on type I collagen gels, chondroitin sulfate mixtures, and to bovine nasal cartilage (BNC), a largely isotropic and homogeneous form of cartilage. The results show that the fractional-order analysis captures important features of NMR relaxation that are typically described by multi-exponential decay models. We find that the T2 relaxation of BNC can be described in a unique way by a single fractional-order parameter (α), in contrast to the lack of uniqueness of multi-exponential fits in the realistic setting of a finite signal-to-noise ratio. No anomalous behavior of T1 was observed in BNC. In the single-component gels, for T2 measurements, increasing the concentration of the largest components of cartilage matrix, collagen and chondroitin sulfate, results in a decrease in α, reflecting a more restricted aqueous environment. The quality of the curve fits obtained using Mittag-Leffler and stretched exponential functions are in some cases superior to those obtained using mono- and bi-exponential models. In both gels and BNC, α appears to account for microstructural complexity in the setting of an altered distribution of relaxation times. This work suggests the utility of fractional-order models to describe T2 NMR relaxation processes in biological tissues. PMID:21498095

  8. Anomalous NMR relaxation in cartilage matrix components and native cartilage: Fractional-order models

    NASA Astrophysics Data System (ADS)

    Magin, Richard L.; Li, Weiguo; Pilar Velasco, M.; Trujillo, Juan; Reiter, David A.; Morgenstern, Ashley; Spencer, Richard G.

    2011-06-01

    We present a fractional-order extension of the Bloch equations to describe anomalous NMR relaxation phenomena ( T1 and T2). The model has solutions in the form of Mittag-Leffler and stretched exponential functions that generalize conventional exponential relaxation. Such functions have been shown by others to be useful for describing dielectric and viscoelastic relaxation in complex, heterogeneous materials. Here, we apply these fractional-order T1 and T2 relaxation models to experiments performed at 9.4 and 11.7 Tesla on type I collagen gels, chondroitin sulfate mixtures, and to bovine nasal cartilage (BNC), a largely isotropic and homogeneous form of cartilage. The results show that the fractional-order analysis captures important features of NMR relaxation that are typically described by multi-exponential decay models. We find that the T2 relaxation of BNC can be described in a unique way by a single fractional-order parameter ( α), in contrast to the lack of uniqueness of multi-exponential fits in the realistic setting of a finite signal-to-noise ratio. No anomalous behavior of T1 was observed in BNC. In the single-component gels, for T2 measurements, increasing the concentration of the largest components of cartilage matrix, collagen and chondroitin sulfate, results in a decrease in α, reflecting a more restricted aqueous environment. The quality of the curve fits obtained using Mittag-Leffler and stretched exponential functions are in some cases superior to those obtained using mono- and bi-exponential models. In both gels and BNC, α appears to account for micro-structural complexity in the setting of an altered distribution of relaxation times. This work suggests the utility of fractional-order models to describe T2 NMR relaxation processes in biological tissues.

  9. Incorporating uncertainty of management costs in sensitivity analyses of matrix population models.

    PubMed

    Salomon, Yacov; McCarthy, Michael A; Taylor, Peter; Wintle, Brendan A

    2013-02-01

    The importance of accounting for economic costs when making environmental-management decisions subject to resource constraints has been increasingly recognized in recent years. In contrast, uncertainty associated with such costs has often been ignored. We developed a method, on the basis of economic theory, that accounts for the uncertainty in population-management decisions. We considered the case where, rather than taking fixed values, model parameters are random variables that represent the situation when parameters are not precisely known. Hence, the outcome is not precisely known either. Instead of maximizing the expected outcome, we maximized the probability of obtaining an outcome above a threshold of acceptability. We derived explicit analytical expressions for the optimal allocation and its associated probability, as a function of the threshold of acceptability, where the model parameters were distributed according to normal and uniform distributions. To illustrate our approach we revisited a previous study that incorporated cost-efficiency analyses in management decisions that were based on perturbation analyses of matrix population models. Incorporating derivations from this study into our framework, we extended the model to address potential uncertainties. We then applied these results to 2 case studies: management of a Koala (Phascolarctos cinereus) population and conservation of an olive ridley sea turtle (Lepidochelys olivacea) population. For low aspirations, that is, when the threshold of acceptability is relatively low, the optimal strategy was obtained by diversifying the allocation of funds. Conversely, for high aspirations, the budget was directed toward management actions with the highest potential effect on the population. The exact optimal allocation was sensitive to the choice of uncertainty model. Our results highlight the importance of accounting for uncertainty when making decisions and suggest that more effort should be placed on

  10. The intraclass covariance matrix.

    PubMed

    Carey, Gregory

    2005-09-01

    Introduced by C.R. Rao in 1945, the intraclass covariance matrix has seen little use in behavioral genetic research, despite the fact that it was developed to deal with family data. Here, I reintroduce this matrix, and outline its estimation and basic properties for data sets on pairs of relatives. The intraclass covariance matrix is appropriate whenever the research design or mathematical model treats the ordering of the members of a pair as random. Because the matrix has only one estimate of a population variance and covariance, both the observed matrix and the residual matrix from a fitted model are easy to inspect visually; there is no need to mentally average homologous statistics. Fitting a model to the intraclass matrix also gives the same log likelihood, likelihood-ratio (LR) chi2, and parameter estimates as fitting that model to the raw data. A major advantage of the intraclass matrix is that only two factors influence the LR chi2--the sampling error in estimating population parameters and the discrepancy between the model and the observed statistics. The more frequently used interclass covariance matrix adds a third factor to the chi2--sampling error of homologous statistics. Because of this, the degrees of freedom for fitting models to an intraclass matrix differ from fitting that model to an interclass matrix. Future research is needed to establish differences in power-if any--between the interclass and the intraclass matrix.

  11. Activated matrix metalloproteinase and disrupted myocardial collagen matrix in increased sympathetic activity following stimulation of dorsal medulla in the vagotomized feline model.

    PubMed

    Cheng, Ching-Chang; Tung, Kwong-Chung; Fu, Yun-Ching; Gong, Chi-Li; Chen, Ying-Tsung; Lin, Nai-Nu; Lin, James A; Chiu, Yung-Tsung

    2008-02-29

    Sympathetic hyperactivation in many kinds of neurocardiogenic injury can result in obvious heart failure. We generated a vagotomized feline model in which sympathetic hyperactivation was induced by electrical stimulation of dorsal medulla (ESDM) of brain stem to investigate the relationship between disruption of extracellular collagen matrix (ECM) and activation of matrix metalloproteinases (MMPs) in myocardium in the sympathetic hyperactivity. Mean blood pressure, heart rate and plasma norepinephrine were all significantly increased from baseline to a peak at 5 min after ESDM. Echocardiographic study showed significant left ventricular dilatation and hypokinesia (ejection fraction: from 87.7 +/- 6.3% to 39.4 +/- 7.8%) from baseline to 180 mm after ESDM. Histopathological finding revealed significant overstretching or spring-like disappearance and disruption of ECM. MMP-2 expression was significantly increased in left ventricular myocardium as compared to sham. These results suggest that ESDM-induced sympathetic hyperactivity causes the expression of MMP-2 that disrupts myocardial ECM, contributing to the development of cardiac dysfunction.

  12. Analytical and numerical modeling of the mechanical behavior of metal matrix composites

    NASA Astrophysics Data System (ADS)

    Elfishawy, Karim Fouad

    Metal matrix composites (MMCs) subjected to both external and thermal cycling loading can experience enhanced creep deformation, leading to dimensional instability in some cases. Three-dimensional finite element models have been constructed to predict the behavior of composites under such loading conditions. The different possible types of composite behavior are discussed in detail. The language and ideas developed in the continuum mechanics area of ratcheting and shakedown was shown to correlate quite closely to the thermal cycling behavior of composites and to apply to their analysis and design. Three composite configurations were analyzed analytically and their models were used to construct Composite Behavior Maps (CBMs). CBMs are diagrams which delineate regions of dimensionally stable and unstable composite behavior, and were shown to have a characteristic shape. Experimental and analytical methods are outlined for constructing conservative CBMs for complex composite configurations for which analytical solutions are not possible. The utility of such diagrams as both an analysis and design tool for MMCs on the microstructural scale is discussed in detail. The fundamental elastic and plastic properties of a new non-traditional alumina/aluminum composite where both phases are continuous, known as Csp4, were investigated analytically using finite element simulations and compared to experimental results. The composite behaves in a nearly bilinear manner defined by an elastic modulus and an elastic-plastic modulus. The apparent plasticity in the composite was shown to occur by true plastic deformation of aluminum and elastic accommodation of alumina. Effects of residual stresses and matrix strength on the tensile and compressive behavior of the composite were also investigated. The concept of selective reinforcement is discussed, along with its special considerations and limitations. The applicability and effectiveness of selective reinforcement as a design approach

  13. Density-matrix based determination of low-energy model Hamiltonians from ab initio wavefunctions

    SciTech Connect

    Changlani, Hitesh J.; Zheng, Huihuo; Wagner, Lucas K.

    2015-09-14

    We propose a way of obtaining effective low energy Hubbard-like model Hamiltonians from ab initio quantum Monte Carlo calculations for molecular and extended systems. The Hamiltonian parameters are fit to best match the ab initio two-body density matrices and energies of the ground and excited states, and thus we refer to the method as ab initio density matrix based downfolding. For benzene (a finite system), we find good agreement with experimentally available energy gaps without using any experimental inputs. For graphene, a two dimensional solid (extended system) with periodic boundary conditions, we find the effective on-site Hubbard U{sup ∗}/t to be 1.3 ± 0.2, comparable to a recent estimate based on the constrained random phase approximation. For molecules, such parameterizations enable calculation of excited states that are usually not accessible within ground state approaches. For solids, the effective Hamiltonian enables large-scale calculations using techniques designed for lattice models.

  14. Singular-potential random-matrix model arising in mean-field glassy systems.

    PubMed

    Akemann, Gernot; Villamaina, Dario; Vivo, Pierpaolo

    2014-06-01

    We consider an invariant random matrix ensemble where the standard Gaussian potential is distorted by an additional single pole of arbitrary fixed order. Potentials with first- and second-order poles have been considered previously and found applications in quantum chaos and number theory. Here we present an application to mean-field glassy systems. We derive and solve the loop equation in the planar limit for the corresponding class of potentials. We find that the resulting mean or macroscopic spectral density is generally supported on two disconnected intervals lying on the two sides of the repulsive pole, whose edge points can be completely determined imposing the additional constraint of traceless matrices on average. For an unbounded potential with an attractive pole, we also find a possible one-cut solution for certain values of the couplings, which is ruled out when the traceless condition is imposed. Motivated by the calculation of the distribution of the spin-glass susceptibility in the Sherrington-Kirkpatrick spin-glass model, we consider in detail a second-order pole for a zero-trace model and provide the most explicit solution in this case. In the limit of a vanishing pole, we recover the standard semicircle. Working in the planar limit, our results apply to matrices with orthogonal, unitary, and symplectic invariance. Numerical simulations and an independent analytical Coulomb fluid calculation for symmetric potentials provide an excellent confirmation of our results.

  15. Brain Mapping-Based Model of Δ(9)-Tetrahydrocannabinol Effects on Connectivity in the Pain Matrix.

    PubMed

    Walter, Carmen; Oertel, Bruno G; Felden, Lisa; Kell, Christian A; Nöth, Ulrike; Vermehren, Johannes; Kaiser, Jochen; Deichmann, Ralf; Lötsch, Jörn

    2016-05-01

    Cannabinoids receive increasing interest as analgesic treatments. However, the clinical use of Δ(9)-tetrahydrocannabinol (Δ(9)-THC) has progressed with justified caution, which also owes to the incomplete mechanistic understanding of its analgesic effects, in particular its interference with the processing of sensory or affective components of pain. The present placebo-controlled crossover study therefore focused on the effects of 20 mg oral THC on the connectivity between brain areas of the pain matrix following experimental stimulation of trigeminal nocisensors in 15 non-addicted healthy volunteers. A general linear model (GLM) analysis identified reduced activations in the hippocampus and the anterior insula following THC administration. However, assessment of psychophysiological interaction (PPI) revealed that the effects of THC first consisted in a weakening of the interaction between the thalamus and the secondary somatosensory cortex (S2). From there, dynamic causal modeling (DCM) was employed to infer that THC attenuated the connections to the hippocampus and to the anterior insula, suggesting that the reduced activations in these regions are secondary to a reduction of the connectivity from somatosensory regions by THC. These findings may have consequences for the way THC effects are currently interpreted: as cannabinoids are increasingly considered in pain treatment, present results provide relevant information about how THC interferes with the affective component of pain. Specifically, the present experiment suggests that THC does not selectively affect limbic regions, but rather interferes with sensory processing which in turn reduces sensory-limbic connectivity, leading to deactivation of affective regions.

  16. Early Embryonic Vascular Patterning by Matrix-Mediated Paracrine Signalling: A Mathematical Model Study

    PubMed Central

    Köhn-Luque, Alvaro; de Back, Walter; Starruß, Jörn; Mattiotti, Andrea; Deutsch, Andreas; Pérez-Pomares, José María; Herrero, Miguel A.

    2011-01-01

    During embryonic vasculogenesis, endothelial precursor cells of mesodermal origin known as angioblasts assemble into a characteristic network pattern. Although a considerable amount of markers and signals involved in this process have been identified, the mechanisms underlying the coalescence of angioblasts into this reticular pattern remain unclear. Various recent studies hypothesize that autocrine regulation of the chemoattractant vascular endothelial growth factor (VEGF) is responsible for the formation of vascular networks in vitro. However, the autocrine regulation hypothesis does not fit well with reported data on in vivo early vascular development. In this study, we propose a mathematical model based on the alternative assumption that endodermal VEGF signalling activity, having a paracrine effect on adjacent angioblasts, is mediated by its binding to the extracellular matrix (ECM). Detailed morphometric analysis of simulated networks and images obtained from in vivo quail embryos reveals the model mimics the vascular patterns with high accuracy. These results show that paracrine signalling can result in the formation of fine-grained cellular networks when mediated by angioblast-produced ECM. This lends additional support to the theory that patterning during early vascular development in the vertebrate embryo is regulated by paracrine signalling. PMID:21949696

  17. Hybrid-space density matrix renormalization group study of the doped two-dimensional Hubbard model

    NASA Astrophysics Data System (ADS)

    Ehlers, G.; White, S. R.; Noack, R. M.

    2017-03-01

    The performance of the density matrix renormalization group (DMRG) is strongly influenced by the choice of the local basis of the underlying physical lattice. We demonstrate that, for the two-dimensional Hubbard model, the hybrid-real-momentum-space formulation of the DMRG is computationally more efficient than the standard real-space formulation. In particular, we show that the computational cost for fixed bond dimension of the hybrid-space DMRG is approximately independent of the width of the lattice, in contrast to the real-space DMRG, for which it is proportional to the width squared. We apply the hybrid-space algorithm to calculate the ground state of the doped two-dimensional Hubbard model on cylinders of width four and six sites; at n =0.875 filling, the ground state exhibits a striped charge-density distribution with a wavelength of eight sites for both U /t =4.0 and 8.0 . We find that the strength of the charge ordering depends on U /t and on the boundary conditions. Furthermore, we investigate the magnetic ordering as well as the decay of the static spin, charge, and pair-field correlation functions.

  18. STAT3 accelerates uterine epithelial regeneration in a mouse model of decellularized uterine matrix transplantation

    PubMed Central

    Hiraoka, Takehiro; Saito-Fujita, Tomoko; Matsuo, Mitsunori; Egashira, Mahiro; Matsumoto, Leona; Haraguchi, Hirofumi; Dey, Sudhansu K.; Furukawa, Katsuko S.; Fujii, Tomoyuki; Osuga, Yutaka

    2016-01-01

    Although a close connection between uterine regeneration and successful pregnancy in both humans and mice has been consistently observed, its molecular basis remains unclear. We here established a mouse model of decellularized uterine matrix (DUM) transplantation. Resected mouse uteri were processed with SDS to make DUMs without any intact cells. DUMs were transplanted into the mouse uteri with artificially induced defects, and all the uterine layers were recovered at the DUM transplantation sites within a month. In the regenerated uteri, normal hormone responsiveness in early pregnancy was observed, suggesting the regeneration of functional uteri. Uterine epithelial cells rapidly migrated and formed a normal uterine epithelial layer within a week, indicating a robust epithelial-regenerating capacity. Stromal and myometrial regeneration occurred following epithelial regeneration. In ovariectomized mice, uterine regeneration of the DUM transplantation was similarly observed, suggesting that ovarian hormones are not essential for this regeneration process. Importantly, the regenerating epithelium around the DUM demonstrated heightened STAT3 phosphorylation and cell proliferation, which was suppressed in uteri of Stat3 conditional knockout mice. These data suggest a key role of STAT3 in the initial step of the uterine regeneration process. The DUM transplantation model is a powerful tool for uterine regeneration research. PMID:27358915

  19. Mechanics and crack formation in the extracellular matrix with articular cartilage as a model system

    NASA Astrophysics Data System (ADS)

    Kearns, Sarah; Silverberg, Jesse; Bonassar, Lawrence; Cohen, Itai; Das, Moumita

    We investigate the mechanical structure-function relations in the extracellular matrix (ECM) with focus on crack formation and failure. As a model system, our study focuses on the ECM in articular cartilage (AC), the tissue that covers the ends of bones, and distributes load in joints including in the knees, shoulders, and hips. The strength, toughness, and crack resistance of native articular cartilage is unparalleled in materials made by humankind. This mechanical response is mainly due to its ECM. The ECM in AC has two major mechanobiological components: a network of the biopolymer collagen and a flexible aggrecan gel. We model this system as a biopolymer network embedded in a swelling gel, and investigate the conditions for the formation and propagation of cracks using a combination of rigidity percolation theory and energy minimization approaches. Our results may provide useful insights into the design principles of the ECM as well as of biomimetic hydrogels that are mechanically robust and can, at the same time, easily adapt to cues in their surroundings. This work was partially supported by a Cottrell College Science Award.

  20. Singular-potential random-matrix model arising in mean-field glassy systems

    NASA Astrophysics Data System (ADS)

    Akemann, Gernot; Villamaina, Dario; Vivo, Pierpaolo

    2014-06-01

    We consider an invariant random matrix ensemble where the standard Gaussian potential is distorted by an additional single pole of arbitrary fixed order. Potentials with first- and second-order poles have been considered previously and found applications in quantum chaos and number theory. Here we present an application to mean-field glassy systems. We derive and solve the loop equation in the planar limit for the corresponding class of potentials. We find that the resulting mean or macroscopic spectral density is generally supported on two disconnected intervals lying on the two sides of the repulsive pole, whose edge points can be completely determined imposing the additional constraint of traceless matrices on average. For an unbounded potential with an attractive pole, we also find a possible one-cut solution for certain values of the couplings, which is ruled out when the traceless condition is imposed. Motivated by the calculation of the distribution of the spin-glass susceptibility in the Sherrington-Kirkpatrick spin-glass model, we consider in detail a second-order pole for a zero-trace model and provide the most explicit solution in this case. In the limit of a vanishing pole, we recover the standard semicircle. Working in the planar limit, our results apply to matrices with orthogonal, unitary, and symplectic invariance. Numerical simulations and an independent analytical Coulomb fluid calculation for symmetric potentials provide an excellent confirmation of our results.

  1. Line-Mixing Relaxation Matrix model for spectroscopic and radiative transfer studies

    NASA Astrophysics Data System (ADS)

    Mendaza, Teresa; Martin-Torres, Javier

    2016-04-01

    We present a generic model to compute the Relaxation Matrix easily adaptable to any molecule and type of spectroscopic lines or bands in non-reactive molecule collisions regimes. It also provides the dipole moment of every transition and level population of the selected molecule. The model is based on the Energy-Corrected Sudden (ECS) approximation/theory introduced by DePristo (1980), and on previous Relaxation Matrix studies for the interaction between molecular ro-vibrational levels (Ben-Rueven, 1966), atoms (Rosenkranz, 1975), linear molecules (Strow and Reuter, 1994; Niro, Boulet and Hartmann, 2004), and symmetric but not linear molecules (Tran et al., 2006). The model is open source, and it is user-friendly. To the point that the user only has to select the wished molecule and vibrational band to perform the calculations. It reads the needed spectroscopic data from the HIgh-resolution TRANsmission molecular absorption (HITRAN) (Rothman et al., 2013) and ExoMol (Tennyson and Yurchenko, 2012). In this work we present an example of the calculations with our model for the case of the 2ν3 band of methane (CH4), and a comparison with a previous work (Tran et al., 2010). The data produced by our model can be used to characterise the line-mixing effects on ro-vibrational lines of the infrared emitters of any atmosphere, to calculate accurate absorption spectra, that are needed in the interpretation of atmospheric spectra, radiative transfer modelling and General Circulation Models (GCM). References [1] A.E. DePristo, Collisional influence on vibration-rotation spectral line shapes: A scaling theoretical analysis and simplification, J. Chem. Phys. 73(5), 1980. [2] A. Ben-Reuven, Impact broadening of microwave spectra, Phys. Rev. 145(1), 7-22, 1966. [3] P.W. Rosenkranz, Shape of the 5 mm Oxygen Band in the Atmosphere, IEEE Transactions on Antennas and Propagation, vol. AP-23, no. 4, pp. 498-506, 1975. [4] Strow, L.L., D.D. Tobin, and S.E. Hannon, A compilation of

  2. Mouse model of pulmonary cavitary tuberculosis and expression of matrix metalloproteinase-9

    PubMed Central

    Ordonez, Alvaro A.; Tasneen, Rokeya; Pokkali, Supriya; Xu, Ziyue; Converse, Paul J.; Klunk, Mariah H.; Mollura, Daniel J.; Nuermberger, Eric L.

    2016-01-01

    ABSTRACT Cavitation is a key pathological feature of human tuberculosis (TB), and is a well-recognized risk factor for transmission of infection, relapse after treatment and the emergence of drug resistance. Despite intense interest in the mechanisms underlying cavitation and its negative impact on treatment outcomes, there has been limited study of this phenomenon, owing in large part to the limitations of existing animal models. Although cavitation does not occur in conventional mouse strains after infection with Mycobacterium tuberculosis, cavitary lung lesions have occasionally been observed in C3HeB/FeJ mice. However, to date, there has been no demonstration that cavitation can be produced consistently enough to support C3HeB/FeJ mice as a new and useful model of cavitary TB. We utilized serial computed tomography (CT) imaging to detect pulmonary cavitation in C3HeB/FeJ mice after aerosol infection with M. tuberculosis. Post-mortem analyses were performed to characterize lung lesions and to localize matrix metalloproteinases (MMPs) previously implicated in cavitary TB in situ. A total of 47-61% of infected mice developed cavities during primary disease or relapse after non-curative treatments. Key pathological features of human TB, including simultaneous presence of multiple pathologies, were noted in lung tissues. Optical imaging demonstrated increased MMP activity in TB lesions and MMP-9 was significantly expressed in cavitary lesions. Tissue MMP-9 activity could be abrogated by specific inhibitors. In situ, three-dimensional analyses of cavitary lesions demonstrated that 22.06% of CD11b+ signal colocalized with MMP-9. C3HeB/FeJ mice represent a reliable, economical and tractable model of cavitary TB, with key similarities to human TB. This model should provide an excellent tool to better understand the pathogenesis of cavitation and its effects on TB treatments. PMID:27482816

  3. Density matrix embedding theory studies of the two-dimensional Hubbard model

    NASA Astrophysics Data System (ADS)

    Zheng, Bo-Xiao

    Density matrix embedding theory (DMET) provides a quantum embedding framework to compute the electronic structure in strongly correlated lattice systems. It has been applied to various model Hamiltonians and ab initio systems. In this talk, I will review the results obtained in the two-dimensional one-band Hubbard model using DMET. Over the last years, we mapped a calibrated ground-state phase diagram of the two-dimensional Hubbard model, concerning magnetic, superconducting and various inhomogeneous phases. Based on the results from this work, as well as the consistent data from other numerical methods, we are able to conclude that many parts of the Hubbard phase diagram is already settled up to an accurate energy scale of 0.001t. Recently, by using large-scale auxiliary-field quantum Monte Carlo (AFQMC) in the impurity problem, we are able to treat much larger embedded clusters at half-filling (and with the constrained path approximation at non-half-filling), which provides a deeper understanding on the finite-size effects of energy and observables in both quantum embedding and finite cluster numerical methods. Finally, we systematically investigated the putative inhomogeneous phases in the underdoped, strong coupling Hubbard model, proposing new inhomogeneous patterns as strong candidates for the ground state. Reference: [1] Bo-Xiao Zheng, Garnet K.-L. Chan, arXiv:1504.01784 [2] J.P.F. Leblanc, Andrey E. Antipov, et al., arXiv:1505.02290 We acknowledge funding from the US Department of Energy, Office of Science, through DE-SC0008624 and DE-SC0010530. This work was also performed as part of the Simons Collaboration on the Many Electron Problem, sponsored by the Simons Foundation.

  4. Climate implications of carbonaceous aerosols: An aerosol microphysical study using the GISS/MATRIX climate model

    NASA Astrophysics Data System (ADS)

    Bauer, S. E.

    2009-12-01

    Recently, attention has been drawn towards black carbon aerosols as a likely short-term climate warming mitigation candidate. However the global and regional impacts of the direct and especially the indirect aerosol forcing effects are highly uncertain, due to the complex nature of aerosol evolution and its climate interactions. Black carbon is directly released as particle into the atmosphere, but then interacts with other gases and particles through condensation and coagulation processes leading to further aerosol growth, aging and internal mixing. Those aerosol characteristics determine their role in direct and indirect aerosol forcing, as their chemical composition and size distribution determine their optical properties and cloud activation potential. A new detailed aerosol microphysical scheme, MATRIX, embedded within the global GISS modelE climate model includes the above processes that determine the lifecycle and climate impact of aerosols. This study presents a quantitative assessment and an uncertainty estimate of the impact of microphysical processes involving black carbon and its optical properties on aerosol cloud activation and radiative forcing. We calculate an anthropogenic net radiative forcing of -0.46 W/m2, relative to emission changes between 1750 and 2000. This study finds the direct and indirect aerosol effect to be very sensitivity towards the size distribution of the emitted black and organic particles. The total net radiative forcing can vary between -0.26 to -0.47 W/m2. The models radiation transfer scheme reacts even more sensitive to black carbon core shell structure assumptions. Assuming that sulfates, nitrates and secondary organics can lead to a coating shell around a black carbon core can turn the overall net radiative forcing from a negative to a positive number. In the light of these sensitivities, black carbon mitigation experiments can show no to up to very significant impact to slower global warming.

  5. Conceptualizing Matrix Multiplication: A Framework for Student Thinking, an Historical Analysis, and a Modeling Perspective

    ERIC Educational Resources Information Center

    Larson, Christine

    2010-01-01

    Little is known about the variety of ways students conceptualize matrix multiplication, yet this is a fundamental part of most introductory linear algebra courses. My dissertation follows a three-paper format, with the three papers exploring conceptualizations of matrix multiplication from a variety of viewpoints. In these papers, I explore (1)…

  6. Influence of PEGylation on nanoparticle mobility in different models of the extracellular matrix.

    PubMed

    Tomasetti, Luise; Liebl, Renate; Wastl, Daniel S; Breunig, Miriam

    2016-11-01

    Nanoparticle transport inside the extracellular matrix (ECM) is a crucial factor affecting the therapeutic success. In this work, two in vitro ECM models - a neutrally charged collagen I network with an effective pore size of 0.47μm and Matrigel, a basement membrane matrix with strong negative charge and effective pore size of 0.14μm - were assessed for barrier function in the context of diffusing nanoparticles. Nanoparticles with a size of 120nm were coated with poly(ethylene glycol) (PEG) of different molecular weights - 2, 5 and 20kDa - over a range of gradually increasing coating densities - precisely 0.2, 2, 8 and 20PEG/nm(2). The PEG corona was imaged in its native state without any drying process by atomic force microscopy, revealing that the experimentally determined arrangement of PEG at the surface did not match with what was theoretically expected. In a systematic investigation of nanoparticle mobility via fluorescence recovery after photobleaching, increasing both PEG MW and PEGylation density gradually improved diffusion properties predominately in collagen. Due to its smaller pore size and electrostatic obstruction, diffusion coefficients were about ten times lower in Matrigel than in the collagen network and an extension of the PEG MW and density did not necessarily lead to better diffusing particles. Consequently, collagen gels were revealed to be a poor model for nanoparticle mobility assessment, as neither their pore size nor their electrostatic properties reflect the expected in vivo conditions. In Matrigel, diffusion proceeded according to a sigmoidal increase with gradually increasing PEG densities showing threshold zeta potentials of 11.6mV (PEG2kDa) and 13.8mV (PEG5kDa), below which particles were regarded as mobile. Irrespective of the molecular weight particles with a PEGylation density lower than 2PEG/nm(2) were defined as immobile and those with a PEG coverage of more than 8PEG/nm(2) as mobile.

  7. Data and Knowledge Base on the Basis of the Expanded Matrix Model of Their Representation for the Intelligent System of Road-Climatic Zoning of Territories

    NASA Astrophysics Data System (ADS)

    Yankovskaya, A.; Cherepanov, D.; Selivanikova, O.

    2016-08-01

    An extended matrix model of data and knowledge representation on the investigated area, as well as a matrix model of data representation on the territory under investigation, are proposed for the intelligent system of road-climatic zoning of territories (RCZT) - the main information technology of RCZT. A part of the West Siberian region has been selected as the investigated territory. The extended matrix model of knowledge representation is filled out by knowledge engineers with participation of highly qualified experts in the field of RCZT. The matrix model of data representation on the territory under investigation is filled out by persons concerned in RCZT of the motor-roads management system.

  8. Neutrino mixing matrix and masses from a generalized Friedberg-Lee model

    NASA Astrophysics Data System (ADS)

    Razzaghi, N.; Gousheh, S. S.

    2014-02-01

    The overall characteristics of the solar and atmospheric neutrino oscillation are approximately consistent with a tribimaximal form of the mixing matrix U of the lepton sector. Exact tribimaximal mixing leads to θ13=0. However, recent results from the Daya Bay and RENO experiments have established a nonzero value for θ13. Keeping the leading behavior of U as tribimaximal, we use a generalized Friedberg-Lee neutrino mass model along with a complementary ansatz to incorporate a nonzero θ13 along with CP violation. We generalize this model in two stages: In the first stage, we assume μ -τ symmetry and add imaginary components which leads to nonzero phases. In the second stage, we add a perturbation with real components which breaks the μ-τ symmetry, and this leads to a nonzero value for θ13. The combination of these two generalizations leads to CP violation. Using only two sets of the experimental data, we can fix all of the parameters of our model and predict not only values for the other experimental data, which agree well with the available data, but also the masses of neutrinos and the CP-violating phases and parameters. These predictions include the following: ⟨mνe⟩≈(0.033-0.037) eV, ⟨mνμ⟩≈(0.043-0.048) eV, ⟨mντ⟩≈(0.046-0.051) eV, and 59.21°≲δ ≲59.34°.

  9. POPULATION-LEVEL RESPONSE OF THE COMMON LOON TO MERCURY IN TWO CANADIAN PROVINCES: A MATRIX MODELING APPROACH

    EPA Science Inventory

    We used data collected from Common Loon Gavia immer populations in two Canadian provinces to demonstrate a matrix population modeling approach for evaluating population-level responses to stressors and to understand how these populations may have responded to mercury contaminatio...

  10. Detection of Q-Matrix Misspecification Using Two Criteria for Validation of Cognitive Structures under the Least Squares Distance Model

    ERIC Educational Resources Information Center

    Romero, Sonia J.; Ordoñez, Xavier G.; Ponsoda, Vincente; Revuelta, Javier

    2014-01-01

    Cognitive Diagnostic Models (CDMs) aim to provide information about the degree to which individuals have mastered specific attributes that underlie the success of these individuals on test items. The Q-matrix is a key element in the application of CDMs, because contains links item-attributes representing the cognitive structure proposed for solve…

  11. Rabbit models of arthritis: immunolocalization of matrix metalloproteinases and tissue inhibitor of metalloproteinase in synovium and cartilage.

    PubMed Central

    Hembry, R. M.; Bagga, M. R.; Murphy, G.; Henderson, B.; Reynolds, J. J.

    1993-01-01

    The distribution of the matrix metalloproteinases, collagenase, stromelysin, gelatinases A and B, and the tissue inhibitor of metalloproteinases in cartilage and synovium removed from rabbits up to 27 days after induction of two models of arthritis was investigated by immunolocalization. Following intra-articular injection of poly-D-lysine/hyaluronic acid coacervate, collagenase and stromelysin were found bound to cartilage matrix, but there was little increase in chondrocyte synthesis of these enzymes. The synovium underwent a complex wound healing response involving invagination and encapsulation of the coacervate and inflammatory cell debris, during which all four metalloproteinases and tissue inhibitor of metalloproteinase could be immunolocalized. The second model, intra-articular injection of ovalbumin into sensitized rabbits, caused considerable chondrocyte necrosis; collagenase was found bound to cartilage matrix on day 13, although again there was little evidence of synthesis by chondrocytes. Inflammatory cell infiltration of meniscoid synovia took place initially, followed by fibrosis involving macrophagelike cells secreting gelatinase A. In both models there was rapid loss of glycosaminoglycan metachromasia from the cartilage matrix. These results are discussed in relation to current knowledge of metalloproteinase involvement in the chronic rheumatoid synovial pannus erosion of cartilage in humans. The data suggest that there are considerable differences between rheumatoid arthritis and these models, and their use must therefore be carefully defined. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 PMID:8342606

  12. Modeling and space vector control of a novel multilevel matrix converter for variable-speed wind power generators

    NASA Astrophysics Data System (ADS)

    Al-Naseem, Osama Abdulrahman

    -quadrant switches used in a conventional matrix converter. This increase in power handling capability is due to the doubling of the number of devices in a multilevel matrix converter switch cell. Scaling up the power handling capability is accomplished by cascading more than one switch cell per branch. Control of the new converter is achieved through space vector modulation in which three-phase ac voltages are transformed to the d-q reference frame and compared with a set of space vectors prior to modulation. Since it has 19683 different switching combinations, control can be difficult and complex. Nevertheless, the multilevel matrix converter has been modeled and controlled through simulation. Simulation results show the possibility of operating the converter to produce the desired voltage waveforms with universal input and output power factors and maintain constant capacitor voltages simultaneously. Also in this dissertation is the derivation of an analytical averaged equivalent circuit model of a PWM converter. This model reveals how dominant loss mechanisms vary with converter operating point. The model is based on the operational characteristics of power diodes and IGBTs. Laboratory experiments support the derived model and confirm that IGBT current tailing and diode reverse-recovery are indeed the most critical losses in a PWM converter. These losses are more significant at light load, hence reducing the energy capture capability of converters used in wind generation. The results suggest that multilevel conversion, which has been employed in the novel multilevel matrix converter, could improve the low-wind converter efficiency.

  13. Modeling State-Space Aeroelastic Systems Using a Simple Matrix Polynomial Approach for the Unsteady Aerodynamics

    NASA Technical Reports Server (NTRS)

    Pototzky, Anthony S.

    2008-01-01

    A simple matrix polynomial approach is introduced for approximating unsteady aerodynamics in the s-plane and ultimately, after combining matrix polynomial coefficients with matrices defining the structure, a matrix polynomial of the flutter equations of motion (EOM) is formed. A technique of recasting the matrix-polynomial form of the flutter EOM into a first order form is also presented that can be used to determine the eigenvalues near the origin and everywhere on the complex plane. An aeroservoelastic (ASE) EOM have been generalized to include the gust terms on the right-hand side. The reasons for developing the new matrix polynomial approach are also presented, which are the following: first, the "workhorse" methods such as the NASTRAN flutter analysis lack the capability to consistently find roots near the origin, along the real axis or accurately find roots farther away from the imaginary axis of the complex plane; and, second, the existing s-plane methods, such as the Roger s s-plane approximation method as implemented in ISAC, do not always give suitable fits of some tabular data of the unsteady aerodynamics. A method available in MATLAB is introduced that will accurately fit generalized aerodynamic force (GAF) coefficients in a tabular data form into the coefficients of a matrix polynomial form. The root-locus results from the NASTRAN pknl flutter analysis, the ISAC-Roger's s-plane method and the present matrix polynomial method are presented and compared for accuracy and for the number and locations of roots.

  14. Characterization of metal matrix composites by linear ultrasonics and finite element modeling.

    PubMed

    Chen, Xuesheng; Sharples, Steve D; Clark, Matt; Wright, David

    2013-02-01

    Titanium metal matrix composites (TiMMCs) offer advantages over traditional materials for aerospace applications due to the increased mechanical strength of the materials. But the non-destructive inspection of these materials, especially with ultrasound, is in an infancy stage. If the manufacturing process of TiMMC is not correctly controlled, then disbonds and voids between the fibers can result. The effective microstructure of the composite makes difficulty to interpret results from traditional ultrasound techniques because of the scattering caused by fibers; the scattering prevents the ultrasound from penetrating far into the composite region and produces a background signal masking any reflections from voids. In this paper, relatively low frequency ultrasound is used to probe the composite region, and the state of the composite (porosity) is inferred from the velocity of the ultrasound traversing the composite. The relationship between the velocity and porosity is complex in this regime, so finite element (FE) analysis is used to model the composite regions and relate the velocity to the porosity. The FE simulated results are validated by ultrasound velocity measurements.

  15. Cauchy-Laguerre Two-Matrix Model and the Meijer-G Random Point Field

    NASA Astrophysics Data System (ADS)

    Bertola, M.; Gekhtman, M.; Szmigielski, J.

    2014-02-01

    We apply the general theory of Cauchy biorthogonal polynomials developed in Bertola et al. (Commun Math Phys 287(3):983-1014, 2009) and Bertola et al. (J Approx Th 162(4):832-867, 2010) to the case associated with Laguerre measures. In particular, we obtain explicit formulae in terms of Meijer-G functions for all key objects relevant to the study of the corresponding biorthogonal polynomials and the Cauchy two-matrix model associated with them. The central theorem we prove is that a scaling limit of the correlation functions for eigenvalues near the origin exists, and is given by a new determinantal two-level random point field, the Meijer-G random field. We conjecture that this random point field leads to a novel universality class of random fields parametrized by exponents of Laguerre weights. We express the joint distributions of the smallest eigenvalues in terms of suitable Fredholm determinants and evaluate them numerically. We also show that in a suitable limit, the Meijer-G random field converges to the Bessel random field and hence the behavior of the eigenvalues of one of the two matrices converges to the one of the Laguerre ensemble.

  16. Synthesis and Characterization of a Model Extracellular Matrix that Induces Partial Regeneration of Adult Mammalian Skin

    NASA Astrophysics Data System (ADS)

    Yannas, I. V.; Lee, E.; Orgill, D. P.; Skrabut, E. M.; Murphy, G. F.

    1989-02-01

    Regeneration of the dermis does not occur spontaneously in the adult mammal. The epidermis is regenerated spontaneously provided there is a dermal substrate over which it can migrate. Certain highly porous, crosslinked collagen--glycosaminoglycan copolymers have induced partial morphogenesis of skin when seeded with dermal and epidermal cells and then grafted on standard, full-thickness skin wounds in the adult guinea pig. A mature epidermis and a nearly physiological dermis, which lacked hair follicles but was demonstrably different from scar, were regenerated over areas as large as 16 cm2. These chemical analogs of extracellular matrices were morphogenetically active provided that the average pore diameter ranged between 20 and 125 μ m, the resistance to degradation by collagenase exceeded a critical limit, and the density of autologous dermal and epidermal cells inoculated therein was >5 × 104 cells per cm2 of wound area. Unseeded copolymers with physical structures that were within these limits delayed the onset of wound contraction by about 10 days but did not eventually prevent it. Seeded copolymers not only delayed contraction but eventually arrested and reversed it while new skin was being regenerated. The data identify a model extracellular matrix that acts as if it were an insoluble growth factor with narrowly specified physicochemical structure, functioning as a transient basal lamina during morphogenesis of skin.

  17. Synthesis and characterization of a model extracellular matrix that induces partial regeneration of adult mammalian skin.

    PubMed Central

    Yannas, I V; Lee, E; Orgill, D P; Skrabut, E M; Murphy, G F

    1989-01-01

    Regeneration of the dermis does not occur spontaneously in the adult mammal. The epidermis is regenerated spontaneously provided there is a dermal substrate over which it can migrate. Certain highly porous, crosslinked collagen-glycosaminoglycan copolymers have induced partial morphogenesis of skin when seeded with dermal and epidermal cells and then grafted on standard, full-thickness skin wounds in the adult guinea pig. A mature epidermis and a nearly physiological dermis, which lacked hair follicles but was demonstrably different from scar, were regenerated over areas as large as 16 cm2. These chemical analogs of extracellular matrices were morphogenetically active provided that the average pore diameter ranged between 20 and 125 microns, the resistance to degradation by collagenase exceeded a critical limit, and the density of autologous dermal and epidermal cells inoculated therein was greater than 5 x 10(4) cells per cm2 of wound area. Unseeded copolymers with physical structures that were within these limits delayed the onset of wound contraction by about 10 days but did not eventually prevent it. Seeded copolymers not only delayed contraction but eventually arrested and reversed it while new skin was being regenerated. The data identify a model extracellular matrix that acts as if it were an insoluble growth factor with narrowly specified physiochemical structure, functioning as a transient basal lamina during morphogenesis of skin. Images PMID:2915988

  18. Efficient model reduction of parametrized systems by matrix discrete empirical interpolation

    NASA Astrophysics Data System (ADS)

    Negri, Federico; Manzoni, Andrea; Amsallem, David

    2015-12-01

    In this work, we apply a Matrix version of the so-called Discrete Empirical Interpolation (MDEIM) for the efficient reduction of nonaffine parametrized systems arising from the discretization of linear partial differential equations. Dealing with affinely parametrized operators is crucial in order to enhance the online solution of reduced-order models (ROMs). However, in many cases such an affine decomposition is not readily available, and must be recovered through (often) intrusive procedures, such as the empirical interpolation method (EIM) and its discrete variant DEIM. In this paper we show that MDEIM represents a very efficient approach to deal with complex physical and geometrical parametrizations in a non-intrusive, efficient and purely algebraic way. We propose different strategies to combine MDEIM with a state approximation resulting either from a reduced basis greedy approach or Proper Orthogonal Decomposition. A posteriori error estimates accounting for the MDEIM error are also developed in the case of parametrized elliptic and parabolic equations. Finally, the capability of MDEIM to generate accurate and efficient ROMs is demonstrated on the solution of two computationally-intensive classes of problems occurring in engineering contexts, namely PDE-constrained shape optimization and parametrized coupled problems.

  19. Test of 600 and 750 MeV NN matrix on elastic scattering Glauber model calculations

    NASA Astrophysics Data System (ADS)

    Brissaud, I.

    1980-09-01

    The 600 and 750 MeV proton nucleus elastic scattering cross section and polarization calculations have been performed in the framework of the Glauber model to test the pp and pn scattering amplitudes deduced from a phase shift analysis by Bystricky, Lechanoine and Lehar. It is well known that up to now we do not possess a non-phenomenological NN scattering matrix at intermediate energies. However proton-nucleus scattering analyses are used to extract information about short range correlations1), Δ resonance2) or pion condensation presences)... etc. Most scattering calculations made at these energies have been done with phenomenological NN amplitudes having a gaussian q-dependence 10050_2005_Article_BF01438168_TeX2GIFE1.gif A(q) = {kσ }/{4π }(α + i) e^{ - β ^2 q^2 /2} and 10050_2005_Article_BF01438168_TeX2GIFE2.gif C(q) = {kσ }/{4π }iq(α + i) D_e - β ^2 q^2 /2 K and σ being respectively the projectile momentum and the total pN total cross section. The parameters α, β and D are badly known and are adjusted by fitting some specific reactions as p+4He elastic scattering4). Even when these amplitudes provide good fits to the data, our understanding of the dynamics of the scattering remains obscure.

  20. Tunneling Current of Electron in Armchair Graphene Nanoribbon Bipolar Transistor Model Using Transfer Matrix Method

    NASA Astrophysics Data System (ADS)

    Fahmi, A. K.; Hasanah, L.; Rusdiana, D.; Aminudin, A.; Suhendi, E.

    2017-03-01

    The tunneling current of n-p-n bipolar junction transistor AGNR-based is modeled with semi-numerical method. The exponential solution from Schrödinger equation is used and solved analytically. The potential profile of n-p-n BJT divided into several segments in the numerical method. Then, the solved analytical result is used in the numerical method to compute the electron transmittance. Transfer Matrix Method (TMM) is the numerical method used to compute the electron transmittance. From the calculated transmittance the tunneling current can be computed by using Landauer formula with aid of Gauss-Legendre Quadrature (GLQ). Next, the tunneling current is computed with several change of variables which are base-emitter voltage (VBE), base-collector voltage (VBC), temperature and the AGNR’s width. The computed tunneling current shows that the larger value of applied voltage for both VBE and VBC results in larger value of tunneling current. At the lower temperature, the current is larger. The computed tunneling current shows that at wider width of AGNR, the current is also larger. This is due to the decreased band-gap energy (Eg) because of the wider width of AGNR.

  1. Optical characterization of murine model's in-vivo skin using Mueller matrix polarimetric imaging

    NASA Astrophysics Data System (ADS)

    Mora-Núñez, Azael; Martinez-Ponce, Geminiano; Garcia-Torales, Guillermo

    2015-12-01

    Mueller matrix polarimetric imaging (MMPI) provides a complete characterization of an anisotropic optical medium. Subsequent single value decomposition allows image interpretation in terms of basic optical anisotropies, such as depolarization, diattenuation, and retardance. In this work, healthy in-vivo skin at different anatomical locations of a biological model (Rattus norvegicus) was imaged by the MMPI technique using 532nm coherent illumination. The body parts under study were back, abdomen, tail, and calvaria. Because skin components are randomly distributed and skin thickness depends on its location, polarization measures arise from the average over a single detection element (pixel) and on the number of free optical paths, respectively. Optical anisotropies over the imaged skin indicates, mainly, the presence of components related to the physiology of the explored region. In addition, a MMPI-based comparison between a tumor on the back of one test subject and proximal healthy skin was made. The results show that the single values of optical anisotropies can be helpful in distinguishing different areas of in-vivo skin and also lesions.

  2. Macrophage Depletion Attenuates Extracellular Matrix Deposition and Ductular Reaction in a Mouse Model of Chronic Cholangiopathies

    PubMed Central

    Syn, Wing-Kin; Lagaisse, Kimberly; van Hul, Noemi; Heindryckx, Femke; Sowa, Jan-Peter; Peeters, Liesbeth; Van Vlierberghe, Hans; Leclercq, Isabelle A.; Canbay, Ali

    2016-01-01

    Chronic cholangiopathies, such as primary and secondary sclerosing cholangitis, are progressive disease entities, associated with periportal accumulation of inflammatory cells, encompassing monocytes and macrophages, peribiliary extracellular matrix (ECM) deposition and ductular reaction (DR). This study aimed to elucidate the relevance of macrophages in the progression of chronic cholangiopathies through macrophage depletion in a 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) mouse model. One group of mice received a single i.p. injection of Clodronate encapsulated liposomes (CLOLipo) at day 7 of a 14 day DDC treatment, while control animals were co-treated with PBSLipo instead. Mice were sacrificed after 7 or respectively 14 days of treatment for immunohistochemical assessment of macrophage recruitment (F4/80), ECM deposition (Sirius Red, Laminin) and DR (CK19). Macrophage depletion during a 14 day DDC treatment resulted in a significant inhibition of ECM deposition. Porto-lobular migration patterns of laminin-rich ECM and ductular structures were significantly attenuated and a progression of DR was effectively inhibited by macrophage depletion. CLOLipo co-treatment resulted in a confined DR to portal regions without amorphous cell clusters. This study suggests that therapeutic options selectively directed towards macrophages might represent a feasible treatment for chronic cholestatic liver diseases. PMID:27618307

  3. [Diagnosis of complementary feeding practices for creating a matrix model for action in primary health care].

    PubMed

    Mais, Laís Amaral; Domene, Semíramis Martins Álvares; Barbosa, Marina Borelli; Taddei, José Augusto de Aguiar Carrazedo

    2014-01-01

    Timely and appropriate complementary feeding is essential for the healthy growth and development of children, and Primary Health Care, especially the Family Health Support Nuclei, are the ideal location for developing relevant actions during this period. A cross-sectional study that applied a questionnaire to mothers and anthropometric evaluation for 324 children sought to develop an index of complementary feeding inadequacies and to study its association with social, economic, clinical, epidemiological and nutritional variables. For quantification of feeding inadequacies, an index using the Delphi method was created. High frequencies were observed for all inadequacies, especially for late introduction of solids (80.2%), early introduction of sugar/thickeners (78.1%) and liquids (73.5%). The most significant results of these associations were early weaning of exclusive (p = 0.000) and total (p = 0.005) breastfeeding, absence of partner (p = 0.001) and the mother supporting the family financially (p = 0.025). The use of this index identifies higher-risk situations for developing a nutritional assistance action plan, especially when it comes to promoting matrix model work.

  4. Modeling and spectral simulation of matrix-isolated molecules by density functional calculations: A case study on formic acid dimer

    NASA Astrophysics Data System (ADS)

    Ito, Fumiyuki

    2010-12-01

    The supermolecule approach has been used to model molecules embedded in solid argon matrix, wherein interaction between the guest and the host atoms in the first solvation shell is evaluated with the use of density functional calculations. Structural stability and simulated spectra have been obtained for formic acid dimer (FAD)-Arn (n = 21-26) clusters. The calculations at the B971/6-31++G(3df,3pd) level have shown that the tetrasubstitutional site on Ar(111) plane is likely to incorporate FAD most stably, in view of consistency with the matrix shifts available experimentally.

  5. Slow molecular motion of different spin probes in a model glycerol—water matrix studied by double modulation ESR

    NASA Astrophysics Data System (ADS)

    Valić, S.; Rakvin, B.; Veksli, Z.; Pečar, S.

    1992-11-01

    The slow molecular motion of several deuterated and undeuterated spin probes differing in size and shape, embedded in a model glycerol—water matrix, have been studied by double-modulated electron spin resonance (DMESR). The DMESR spectra as a function of temperature reveal two motional regions. From the experimental linewidths of both deuterated and undeuterated spin probes in the lower temperature region and simulated data based on the variation of T1 relaxation, two different dynamics of the -CH 3 groups attached to piperidine ring were resolved. Our results indicate that the onset of the whole spin probe motion depends on the type of probe and the matrix density.

  6. Incorporating Plasticity of the Interfibrillar Matrix in Shear Lag Models is Necessary to Replicate the Multiscale Mechanics of Tendon Fascicles

    PubMed Central

    Szczesny, Spencer E.; Elliott, Dawn M.

    2015-01-01

    Despite current knowledge of tendon structure, the fundamental deformation mechanisms underlying tendon mechanics and failure are unknown. We recently showed that a shear lag model, which explicitly assumed plastic interfibrillar load transfer between discontinuous fibrils, could explain the multiscale fascicle mechanics, suggesting that fascicle yielding is due to plastic deformation of the interfibrillar matrix. However, it is unclear whether alternative physical mechanisms, such as elastic interfibrillar deformation or fibril yielding, also contribute to fascicle mechanical behavior. The objective of the current work was to determine if plasticity of the interfibrillar matrix is uniquely capable of explaining the multiscale mechanics of tendon fascicles including the tissue post-yield behavior. This was examined by comparing the predictions of a continuous fibril model and three separate shear lag models incorporating an elastic, plastic, or elastoplastic interfibrillar matrix with multiscale experimental data. The predicted effects of fibril yielding on each of these models were also considered. The results demonstrated that neither the continuous fibril model nor the elastic shear lag model can successfully predict the experimental data, even if fibril yielding is included. Only the plastic or elastoplastic shear lag models were capable of reproducing the multiscale tendon fascicle mechanics. Differences between these two models were small, although the elastoplastic model did improve the fit of the experimental data at low applied tissue strains. These findings suggest that while interfibrillar elasticity contributes to the initial stress response, plastic deformation of the interfibrillar matrix is responsible for tendon fascicle post-yield behavior. This information sheds light on the physical processes underlying tendon failure, which is essential to improve our understanding of tissue pathology and guide the development of successful repair. PMID:25262202

  7. S100A4 upregulation suppresses tissue ossification and enhances matrix degradation in experimental periodontitis models

    PubMed Central

    Zhou, Min; Li, Zhuo-quan; Wang, Zuo-lin

    2015-01-01

    Aim: S100A4, also known as fibroblast-specific protein 1 or metastasin 1, is not only highly expressed in growth-stimulated cultured cells and metastatic tumor cells, but also in the periodontal ligament. The aim of this study was to investigate the roles of S100A4 in the pathogenesis of periodontitis and its regulatory mechanisms in inflammatory milieu. Methods: Experimental periodontitis was induced in rats by submarginal silk ligatures. TRAP activity and S100A4 expression in periodontal ligaments were examined using immunohistochemistry and immunofluorescence methods. IL-1β-treated human periodontal ligament cells (hPDLCs) were used as in vitro model of experimental periodontitis. S100A4 mRNA and protein were assessed using qRT-PCR and Western blot, respectively. hPDLCs were transfected with either S100A4 overexpression plasmids or shRNAs plasmids. The mineralization in hPDLCs was evaluated with a 12-d osteogenic induction assay, and the expression of ALP, OCN, MMP-2 and MMP-13 was analyzed by qRT-PCR. Results: In the periodontal ligaments of rats with experimental periodontitis, TRAP activity and S100A4 protein staining were considerably more intense compared with those in the control rats. Treatment of hPDLCs with IL-1β (10, 50 and 100 ng/mL) dose-dependently increased the mRNA and protein levels of S100A4. Transfection with shRNAs markedly increased mineralized nodule formation and the osteogenic-related markers ALP and OCN levels in hPDLCs, whereas the overexpression of S100A4 significantly reduced mineralized nodule formation, and increased the matrix degradation enzymes MMP-2 and MMP-13 levels in hPDLCs. Conclusion: S100A4 is upregulated in the experimental rat periodontitis and in IL-1β-treated hPDLCs, where S100A4 suppresses osteogenic differentiation and enhances matrix degradation. Thus, S100A4 is a potential target for the treatment of periodontitis. PMID:26499072

  8. User's guide for SAMMY: a computer model for multilevel r-matrix fits to neutron data using Bayes' equations

    SciTech Connect

    Larson, N. M.; Perey, F. G.

    1980-11-01

    A method is described for determining the parameters of a model from experimental data based upon the utilization of Bayes' theorem. This method has several advantages over the least-squares method as it is commonly used; one important advantage is that the assumptions under which the parameter values have been determined are more clearly evident than in many results based upon least squares. Bayes' method has been used to develop a computer code which can be utilized to analyze neutron cross-section data by means of the R-matrix theory. The required formulae from the R-matrix theory are presented, and the computer implementation of both Bayes' equations and R-matrix theory is described. Details about the computer code and compelte input/output information are given.

  9. Time-dependent occupation numbers in reduced-density-matrix-functional theory: Application to an interacting Landau-Zener model

    SciTech Connect

    Requist, Ryan; Pankratov, Oleg

    2011-05-15

    We prove that if the two-body terms in the equation of motion for the one-body reduced density matrix are approximated by ground-state functionals, the eigenvalues of the one-body reduced density matrix (occupation numbers) remain constant in time. This deficiency is related to the inability of such an approximation to account for relative phases in the two-body reduced density matrix. We derive an exact differential equation giving the functional dependence of these phases in an interacting Landau-Zener model and study their behavior in short- and long-time regimes. The phases undergo resonances whenever the occupation numbers approach the boundaries of the interval [0,1]. In the long-time regime, the occupation numbers display correlation-induced oscillations and the memory dependence of the functionals assumes a simple form.

  10. Transfer matrix computation of critical polynomials for two-dimensional Potts models

    DOE PAGES

    Jacobsen, Jesper Lykke; Scullard, Christian R.

    2013-02-04

    We showed, In our previous work, that critical manifolds of the q-state Potts model can be studied by means of a graph polynomial PB(q, v), henceforth referred to as the critical polynomial. This polynomial may be defined on any periodic two-dimensional lattice. It depends on a finite subgraph B, called the basis, and the manner in which B is tiled to construct the lattice. The real roots v = eK — 1 of PB(q, v) either give the exact critical points for the lattice, or provide approximations that, in principle, can be made arbitrarily accurate by increasing the size ofmore » B in an appropriate way. In earlier work, PB(q, v) was defined by a contraction-deletion identity, similar to that satisfied by the Tutte polynomial. Here, we give a probabilistic definition of PB(q, v), which facilitates its computation, using the transfer matrix, on much larger B than was previously possible.We present results for the critical polynomial on the (4, 82), kagome, and (3, 122) lattices for bases of up to respectively 96, 162, and 243 edges, compared to the limit of 36 edges with contraction-deletion. We discuss in detail the role of the symmetries and the embedding of B. The critical temperatures vc obtained for ferromagnetic (v > 0) Potts models are at least as precise as the best available results from Monte Carlo simulations or series expansions. For instance, with q = 3 we obtain vc(4, 82) = 3.742 489 (4), vc(kagome) = 1.876 459 7 (2), and vc(3, 122) = 5.033 078 49 (4), the precision being comparable or superior to the best simulation results. More generally, we trace the critical manifolds in the real (q, v) plane and discuss the intricate structure of the phase diagram in the antiferromagnetic (v < 0) region.« less

  11. Climate implications of carbonaceous aerosols: An aerosol microphysical study using the GISS/MATRIX climate model

    SciTech Connect

    Bauer, Susanne E.; Menon, Surabi; Koch, Dorothy; Bond, Tami; Tsigaridis, Kostas

    2010-04-09

    Recently, attention has been drawn towards black carbon aerosols as a likely short-term climate warming mitigation candidate. However the global and regional impacts of the direct, cloud-indirect and semi-direct forcing effects are highly uncertain, due to the complex nature of aerosol evolution and its climate interactions. Black carbon is directly released as particle into the atmosphere, but then interacts with other gases and particles through condensation and coagulation processes leading to further aerosol growth, aging and internal mixing. A detailed aerosol microphysical scheme, MATRIX, embedded within the global GISS modelE includes the above processes that determine the lifecycle and climate impact of aerosols. This study presents a quantitative assessment of the impact of microphysical processes involving black carbon, such as emission size distributions and optical properties on aerosol cloud activation and radiative forcing. Our best estimate for net direct and indirect aerosol radiative forcing change is -0.56 W/m{sup 2} between 1750 and 2000. However, the direct and indirect aerosol effects are very sensitive to the black and organic carbon size distribution and consequential mixing state. The net radiative forcing change can vary between -0.32 to -0.75 W/m{sup 2} depending on these carbonaceous particle properties. Assuming that sulfates, nitrates and secondary organics form a coating shell around a black carbon core, rather than forming a uniformly mixed particles, changes the overall net radiative forcing from a negative to a positive number. Black carbon mitigation scenarios showed generally a benefit when mainly black carbon sources such as diesel emissions are reduced, reducing organic and black carbon sources such as bio-fuels, does not lead to reduced warming.

  12. Modeling for Fatigue Hysteresis Loops of Carbon Fiber-Reinforced Ceramic-Matrix Composites under Multiple Loading Stress Levels

    NASA Astrophysics Data System (ADS)

    Longbiao, Li

    2015-12-01

    In this paper, the fatigue hysteresis loops of fiber-reinforced ceramic-matrix composites (CMCs) under multiple loading stress levels considering interface wear has been investigated using micromechanical approach. Under fatigue loading, the fiber/matrix interface shear stress decreases with the increase of cycle number due to interface wear. Upon increasing of fatigue peak stress, the interface debonded length would propagate along the fiber/matrix interface. The difference of interface shear stress existed in the new and original debonded region would affect the interface debonding and interface frictional slipping between the fiber and the matrix. Based on the fatigue damage mechanism of fiber slipping relative to matrix in the interface debonded region upon unloading and subsequent reloading, the interface slip lengths, i.e., the interface debonded length, interface counter-slip length and interface new-slip length, are determined by fracture mechanics approach. The fatigue hysteresis loops models under multiple loading stress levels have been developed. The effects of single/multiple loading stress levels and different loading sequences on fatigue hysteresis loops have been investigated. The fatigue hysteresis loops of unidirectional C/SiC composite under multiple loading stress levels have been predicted.

  13. Modeling the Nonlinear, Strain Rate Dependent Deformation of Woven Ceramic Matrix Composites With Hydrostatic Stress Effects Included

    NASA Technical Reports Server (NTRS)

    Goldberg, Robert K.; Carney, Kelly S.

    2004-01-01

    An analysis method based on a deformation (as opposed to damage) approach has been developed to model the strain rate dependent, nonlinear deformation of woven ceramic matrix composites with a plain weave fiber architecture. In the developed model, the differences in the tension and compression response have also been considered. State variable based viscoplastic equations originally developed for metals have been modified to analyze the ceramic matrix composites. To account for the tension/compression asymmetry in the material, the effective stress and effective inelastic strain definitions have been modified. The equations have also been modified to account for the fact that in an orthotropic composite the in-plane shear stiffness is independent of the stiffness in the normal directions. The developed equations have been implemented into a commercially available transient dynamic finite element code, LS-DYNA, through the use of user defined subroutines (UMATs). The tensile, compressive, and shear deformation of a representative plain weave woven ceramic matrix composite are computed and compared to experimental results. The computed values correlate well to the experimental data, demonstrating the ability of the model to accurately compute the deformation response of woven ceramic matrix composites.

  14. RECEPTOR MODELING OF AMBIENT PARTICULATE MATTER DATA USING POSITIVE MATRIX FACTORIZATION REVIEW OF EXISTING METHODS

    EPA Science Inventory

    Methods for apportioning sources of ambient particulate matter (PM) using the positive matrix factorization (PMF) algorithm are reviewed. Numerous procedural decisions must be made and algorithmic parameters selected when analyzing PM data with PMF. However, few publications docu...

  15. A model for overview of student learning: a matrix of educational outcomes versus methodologies.

    PubMed

    Johnsen, David C; Marshall, Teresa A; Finkelstein, Michael W; Cunningham-Ford, Marsha A; Straub-Morarend, Cheryl L; Holmes, David C; Armstrong, Steven R; Aquilino, Steven A; Sharp, Helen M; Solow, Catherine M; McQuistan, Michelle R

    2011-02-01

    A concise overview of an institution's aspirations for its students becomes increasingly elusive because dental education has evolving emphases on priorities like critical thinking and adapting to new technology. The purpose of this article is to offer a learner-oriented matrix that gives a focus for discussion and an overview of an institution's educational outcomes. On one axis of the matrix, common educational outcomes are listed: knowledge, technical skills, critical thinking, ethical and professional values, patient and practice management, and social responsibility awareness. On the other axis, methodologies are listed: definition, cultivation strategies, measures (summative/formative, objective/subjective), institutional coordination, and competency determination. By completing the matrix, an overview of the process by which students reach these outcomes emerges. Each institution would likely complete the matrix differently and, ideally, with active discussion. While the matrix can first be used to establish "Where are we now?" for an institution, it can also be a starting point for more extensive matrices and further discussion. Vertical and horizontal analyses of the matrix provide a unique lens for viewing the institution's learning environment.

  16. Modeling of stress/strain behavior of fiber-reinforced ceramic matrix composites including stress redistribution

    NASA Technical Reports Server (NTRS)

    Mital, Subodh K.; Murthy, Pappu L. N.; Chamis, Christos C.

    1994-01-01

    A computational simulation procedure is presented for nonlinear analyses which incorporates microstress redistribution due to progressive fracture in ceramic matrix composites. This procedure facilitates an accurate simulation of the stress-strain behavior of ceramic matrix composites up to failure. The nonlinearity in the material behavior is accounted for at the constituent (fiber/matrix/interphase) level. This computational procedure is a part of recent upgrades to CEMCAN (Ceramic Matrix Composite Analyzer) computer code. The fiber substructuring technique in CEMCAN is used to monitor the damage initiation and progression as the load increases. The room-temperature tensile stress-strain curves for SiC fiber reinforced reaction-bonded silicon nitride (RBSN) matrix unidirectional and angle-ply laminates are simulated and compared with experimentally observed stress-strain behavior. Comparison between the predicted stress/strain behavior and experimental stress/strain curves is good. Collectively the results demonstrate that CEMCAN computer code provides the user with an effective computational tool to simulate the behavior of ceramic matrix composites.

  17. Estimating the model resolution matrix for large seismic tomography problems based on Lanczos bidiagonalization with partial reorthogonalization

    NASA Astrophysics Data System (ADS)

    Zhang, H.; Thurber, C. H.

    2007-07-01

    The PROPACK package developed by Larsen is able to efficiently and accurately estimate singular values and vectors for large matrices based on the Lanczos bidiagonalization with partial reorthogonalization. We incorporate the Pavtial Reorthogonalization Package (PROPACK) package into the double-difference seismic tomography code tomoDD and estimate the model resolution matrix for large seismic tomography problems. Compared to previous Least Squares QR (LSQR)-based methods for estimating the model resolution matrix the PROPACK-based method calculates the full resolution matrix and thus gives a complete description of how well the model is resolved. Several observations are drawn from the application to data from the 2001 eruption of Mt Etna: for this example, it is reasonable to use ray-sampling density information to characterize the model resolution qualitatively; the model resolution resulting from just velocity inversion bears a close linear relationship to that from simultaneous inversion but always overestimates resolution; and the inversion system using differential times has a greater ability to resolve the source region structure than the system using absolute times.

  18. Modelling the matrix shift on the vibrational frequency of ThO by DFT-D3 calculations

    NASA Astrophysics Data System (ADS)

    Kovács, Attila; Rode, Joanna E.

    2017-03-01

    Benchmark calculations with a goal to find dispersion-corrected DFT-D3 methods suitable for a reliable estimation of matrix shifts on the vibrational frequency were carried out on the ThO molecule in three rare gas (Rg = Ne, Ar, and Kr) matrices. The matrices were modelled by the explicit approach, in which a single and a double shell of Rg atoms around ThO was considered. The selection of exchange-correlation functionals was based on test calculations on triatomic ThO⋯ Rg models. The B3LYP, PBE0, CAM-B3LYP, and LC-ω PBE functionals were found to be the best suited for the estimation of matrix shifts. The single shell of Rg's around ThO accounted for a major part of the shifts; the addition of a second Rg shell resulted only in a minor improvement. Continuum solvation models considerably overestimated the effect of Rg matrices both when the whole matrix was treated by the model and when the first shell was treated explicitly and the rest with a continuum solvation model.

  19. MATRIX (Multiconfiguration Aerosol TRacker of mIXing state): an aerosol microphysical module for global atmospheric models

    NASA Astrophysics Data System (ADS)

    Bauer, S. E.; Wright, D. L.; Koch, D.; Lewis, E. R.; McGraw, R.; Chang, L.-S.; Schwartz, S. E.; Ruedy, R.

    2008-10-01

    A new aerosol microphysical module MATRIX, the Multiconfiguration Aerosol TRacker of mIXing state, and its application in the Goddard Institute for Space Studies (GISS) climate model (ModelE) are described. This module, which is based on the quadrature method of moments (QMOM), represents nucleation, condensation, coagulation, internal and external mixing, and cloud-drop activation and provides aerosol particle mass and number concentration and particle size information for up to 16 mixed-mode aerosol populations. Internal and external mixing among aerosol components sulfate, nitrate, ammonium, carbonaceous aerosols, dust and sea-salt particles are represented. The solubility of each aerosol population, which is explicitly calculated based on its soluble and insoluble components, enables calculation of the dependence of cloud drop activation on the microphysical characterization of multiple soluble aerosol populations. A detailed model description and results of box-model simulations of various aerosol population configurations are presented. The box model experiments demonstrate the dependence of cloud activating aerosol number concentration on the aerosol population configuration; comparisons to sectional models are quite favorable. MATRIX is incorporated into the GISS climate model and simulations are carried out primarily to assess its performance/efficiency for global-scale atmospheric model application. Simulation results were compared with aircraft and station measurements of aerosol mass and number concentration and particle size to assess the ability of the new method to yield data suitable for such comparison. The model accurately captures the observed size distributions in the Aitken and accumulation modes up to particle diameter 1 μm, in which sulfate, nitrate, black and organic carbon are predominantly located; however the model underestimates coarse-mode number concentration and size, especially in the marine environment. This is more likely due to

  20. Detection and monitoring of localized matrix metalloproteinase upregulation in a murine model of asthma

    PubMed Central

    Felsen, Csilla N.; Savariar, Elamprakash N.; Whitney, Michael

    2014-01-01

    Extracellular proteases including matrix metalloproteinases (MMPs) are speculated to play a significant role in chronic lung diseases, such as asthma. Although increased protease expression has been correlated with lung pathogenesis, the relationship between localized enzyme activity and disease progression remains poorly understood. We report the application of MMP-2/9 activatable cell-penetrating peptides (ACPPs) and their ratiometric analogs (RACPPs) for in vivo measurement of protease activity and distribution in the lungs of mice that were challenged with the allergen ovalbumin. MMP-2/9 activity was increased greater than twofold in whole, dissected lungs from acutely challenged mice compared with control mice (P = 1.8 × 10−4). This upregulation of MMP-2/9 activity was localized around inflamed airways with 1.6-fold higher protease-dependent ACPP uptake surrounding diseased airways compared with adjacent, pathologically normal lung parenchyma (P = 0.03). MMP-2/9 activity detected by ACPP cleavage colocalized with gelatinase activity measured with in situ dye-quenched gelatin. For comparison, neutrophil elastase activity and thrombin activity, detected with elastase- and thrombin-cleavable RACPPs, respectively, were not significantly elevated in acutely allergen-challenged mouse lungs. The results demonstrate that ACPPs, like the MMP-2/9-activated and related ACPPs, allow for real-time detection of protease activity in a murine asthma model, which should improve our understanding of protease activation in asthma disease progression and help elucidate new therapy targets or act as a mechanism for therapeutic drug delivery. PMID:24508733

  1. Matrix Metalloproteinase-8 Augments Bacterial Clearance in a Juvenile Sepsis Model

    PubMed Central

    Atkinson, Sarah J; Varisco, Brian M; Sandquist, Mary; Daly, Meghan N; Klingbeil, Lindsey; Kuethe, Joshua W; Midura, Emily F; Harmon, Kelli; Opoka, Amy; Lahni, Patrick; Piraino, Giovanna; Hake, Paul; Zingarelli, Basilia; Mortensen, Joel E; Wynn, James L; Wong, Hector R

    2016-01-01

    Genetic ablation or pharmacologic inhibition of matrix metalloproteinase-8 (MMP8) improves survival in an adult murine sepsis model. Because developmental age influences the host inflammatory response, we hypothesized that developmental age influences the role of MMP8 in sepsis. First, we compared sepsis survival between wild-type (WT, C57BL/6) and MMP8 null juvenile-aged mice (12–14 d) after intraperitoneal injection of a standardized cecal slurry. Second, peritoneal lavages collected 6 h and 18 h after cecal slurry injection were analyzed for bacterial burden, leukocyte subsets and inflammatory cytokines. Third, juvenile WT mice were pretreated with an MMP8 inhibitor prior to cecal slurry injection; analysis of their bacterial burden was compared with vehicle-injected animals. Fourth, the phagocytic capacity of WT and MMP8 null peritoneal macrophages was compared. Finally, peritoneal neutrophil extracellular traps (NETs) were compared using immunofluorescent imaging and quantitative image analysis. We found that juvenile MMP8 null mice had greater mortality and higher bacterial burden than WT mice. Leukocyte counts and cytokine concentrations in the peritoneal fluid were increased in the MMP8 null mice relative to the wild-type mice. Peritoneal macrophages from MMP8 null mice had reduced phagocytic capacity compared to WT macrophages. There was no quantitative difference in NET formation, but fewer bacteria were adherent to NETs from MMP8 null animals. In conclusion, in contrast to septic adult mice, genetic ablation of MMP8 increased mortality following bacterial peritonitis in juvenile mice. This increase in mortality was associated with reduced bacterial clearance and reduced NET efficiency. We conclude that developmental age influences the role of MMP8 in sepsis. PMID:27506554

  2. Transfer matrix computation of critical polynomials for two-dimensional Potts models

    SciTech Connect

    Jacobsen, Jesper Lykke; Scullard, Christian R.

    2013-02-04

    We showed, In our previous work, that critical manifolds of the q-state Potts model can be studied by means of a graph polynomial PB(q, v), henceforth referred to as the critical polynomial. This polynomial may be defined on any periodic two-dimensional lattice. It depends on a finite subgraph B, called the basis, and the manner in which B is tiled to construct the lattice. The real roots v = eK — 1 of PB(q, v) either give the exact critical points for the lattice, or provide approximations that, in principle, can be made arbitrarily accurate by increasing the size of B in an appropriate way. In earlier work, PB(q, v) was defined by a contraction-deletion identity, similar to that satisfied by the Tutte polynomial. Here, we give a probabilistic definition of PB(q, v), which facilitates its computation, using the transfer matrix, on much larger B than was previously possible.We present results for the critical polynomial on the (4, 82), kagome, and (3, 122) lattices for bases of up to respectively 96, 162, and 243 edges, compared to the limit of 36 edges with contraction-deletion. We discuss in detail the role of the symmetries and the embedding of B. The critical temperatures vc obtained for ferromagnetic (v > 0) Potts models are at least as precise as the best available results from Monte Carlo simulations or series expansions. For instance, with q = 3 we obtain vc(4, 82) = 3.742 489 (4), vc(kagome) = 1.876 459 7 (2), and vc(3, 122) = 5.033 078 49 (4), the precision being comparable or superior to the best simulation results. More generally, we trace the critical manifolds in the real (q, v) plane and discuss the intricate structure of the phase diagram in the antiferromagnetic (v < 0) region.

  3. Three-Dimensional In Vitro Skin and Skin Cancer Models Based on Human Fibroblast-Derived Matrix.

    PubMed

    Berning, Manuel; Prätzel-Wunder, Silke; Bickenbach, Jackie R; Boukamp, Petra

    2015-09-01

    Three-dimensional in vitro skin and skin cancer models help to dissect epidermal-dermal and tumor-stroma interactions. In the model presented here, normal human dermal fibroblasts isolated from adult skin self-assembled into dermal equivalents with their specific fibroblast-derived matrix (fdmDE) over 4 weeks. The fdmDE represented a complex human extracellular matrix that was stabilized by its own heterogeneous collagen fiber meshwork, largely resembling a human dermal in vivo architecture. Complemented with normal human epidermal keratinocytes, the skin equivalent (fdmSE) thereof favored the establishment of a well-stratified and differentiated epidermis and importantly allowed epidermal regeneration in vitro for at least 24 weeks. Moreover, the fdmDE could be used to study the features of cutaneous skin cancer. Complementing fdmDE with HaCaT cells in different stages of malignancy or tumor-derived cutaneous squamous cell carcinoma cell lines, the resulting skin cancer equivalents (fdmSCEs) recapitulated the respective degree of tumorigenicity. In addition, the fdmSCE invasion phenotypes correlated with their individual degree of tissue organization, disturbance in basement membrane organization, and presence of matrix metalloproteinases. Together, fdmDE-based models are well suited for long-term regeneration of normal human epidermis and, as they recapitulate tumor-specific growth, differentiation, and invasion profiles of cutaneous skin cancer cells, also provide an excellent human in vitro skin cancer model.

  4. Extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloproteinases (MMPs) as regulators of tumor-host interaction in a spontaneous metastasis model in rats.

    PubMed

    Donadio, Ana Carolina; Remedi, María Mónica; Susperreguy, Sebastián; Frede, Silvia; Gilardoni, Mónica Beatriz; Tang, Yi; Pellizas, Claudia Gabriela; Yan, Li

    2008-12-01

    EMMPRIN has a role in invasion and metastasis through the induction of MMPs and the consequent modulation of cell-substrate and cell-cell adhesion processes. The present study evaluates the expression of EMMPRIN protein and MMP-2/9 activity in tumor and parenchymal cells in a spontaneous metastasis model in rats. Moreover, we explore the regulation of EMMPRIN and MMP-9 by tumor-epithelial cell interactions in vitro. By zymography, we observed an increased proMMP-9 expression in both metastasized liver and spleen samples from tumor bearing rats. Immunohistochemical studies showed EMMPRIN-positive tumor cells in tumor biopsies as well as in spleen and liver samples from tumor bearing rats. Interestingly, a significant increase in EMMPRIN expression in hepatic cells was also detected. The regulation of EMMPRIN expression in tumor and liver cells in response to tumor-host interaction was investigated in vitro through a tumor cell line culture on extracellular matrix (ECM) molecules or in co-culture with normal rat liver cells (BRL3A cells). No significant changes in EMMPRIN expression were detected in tumor cells cultured on ECM molecules. On the other hand, EMMPRIN protein and MMP-9 mRNA expression were induced in BRL3A cells. The increase in EMMPRIN expression in BRL3A cells was inhibited by an anti-EMMPRIN antibody. These results reinforce the main role of EMMPRIN mediating tumor-host interactions that may evolve new opportunities for therapeutic interventions.

  5. Regulation of Extracellular Matrix Remodeling Proteins by Osteoblasts in Titanium Nanoparticle-Induced Aseptic Loosening Model.

    PubMed

    Xie, Jing; Hou, Yanhua; Fu, Na; Cai, Xiaoxiao; Li, Guo; Peng, Qiang; Lin, Yunfeng

    2015-10-01

    Titanium (Ti)-wear particles, formed at the bone-implant interface, are responsible for aseptic loosening, which is a main cause of total joint replacement failure. There have been many studies on Ti particle-induced function changes in mono-cultured osteoblasts and synovial cells. However, little is known on extracellular matrix remodeling displayed by osteoblasts when in coexistence with Synovial cells. To further mimic the bone-implant interface environment, we firstly established a nanoscaled-Ti particle-induced aseptic loosening system by co-culturing osteoblasts and Synovial cells. We then explored the impact of the Synovial cells on Ti particle-engulfed osteoblasts in the mimicked flamed niche. The matrix metalloproteinases and lysyl oxidases expression levels, two protein families which are critical in osseointegration, were examined under induction by tumor necrosis factor-alpha. It was found that the co-culture between the osteoblasts and Synovial cells markedly increased the migration and proliferation of the osteoblasts, even in the Ti-particle engulfed osteoblasts. Importantly, the Ti-particle engulfed osteoblasts, induced by TNF-alpha after the co-culture, enhanced the release of the matrix metalloproteinases and reduced the expressions of lysyl oxidases. The regulation of extracellular matrix remodeling at the protein level was further assessed by investigations on gene expression of the matrix metalloproteinases and lysyl oxidases, which also suggested that the regulation started at the genetic level. Our research work has therefore revealed the critical role of multi cell-type interactions in the extracellular matrix remodeling within the peri-prosthetic tissues, which provides new insights on aseptic loosening and brings new clues about incomplete osseointegration between the implantation materials and their surrounding bones.

  6. On the universal {\\boldmath R}-matrix for the Izergin-Korepin model

    NASA Astrophysics Data System (ADS)

    Boos, Herman; Göhmann, Frank; Klümper, Andreas; Nirov, Khazret S.; Razumov, Alexander V.

    2011-09-01

    We continue our exercises with the universal R-matrix based on the Khoroshkin and Tolstoy formula. Here we present our results for the case of the twisted affine Kac-Moody Lie algebra of type A(2)2. Our interest in this case is inspired by the fact that the Tzitzéica equation is associated with A(2)2 in a similar way as the sine-Gordon equation is related to A(1)1. The fundamental spin-chain Hamiltonian is constructed systematically as the logarithmic derivative of the transfer matrix. L-operators of two types are obtained by using q-deformed oscillators.

  7. Ion Yields in the Coupled Chemical and Physical Dynamics Model of Matrix-Assisted Laser Desorption/Ionization

    NASA Astrophysics Data System (ADS)

    Knochenmuss, Richard

    2015-08-01

    The Coupled Chemical and Physical Dynamics (CPCD) model of matrix assisted laser desorption ionization has been restricted to relative rather than absolute yield comparisons because the rate constant for one step in the model was not accurately known. Recent measurements are used to constrain this constant, leading to good agreement with experimental yield versus fluence data for 2,5-dihydroxybenzoic acid. Parameters for alpha-cyano-4-hydroxycinnamic acid are also estimated, including contributions from a possible triplet state. The results are compared with the polar fluid model, the CPCD is found to give better agreement with the data.

  8. Integrating Temperature-Dependent Life Table Data into a Matrix Projection Model for Drosophila suzukii Population Estimation

    PubMed Central

    Wiman, Nik G.; Walton, Vaughn M.; Dalton, Daniel T.; Anfora, Gianfranco; Burrack, Hannah J.; Chiu, Joanna C.; Daane, Kent M.; Grassi, Alberto; Miller, Betsey; Tochen, Samantha; Wang, Xingeng; Ioriatti, Claudio

    2014-01-01

    Temperature-dependent fecundity and survival data was integrated into a matrix population model to describe relative Drosophila suzukii Matsumura (Diptera: Drosophilidae) population increase and age structure based on environmental conditions. This novel modification of the classic Leslie matrix population model is presented as a way to examine how insect populations interact with the environment, and has application as a predictor of population density. For D. suzukii, we examined model implications for pest pressure on crops. As case studies, we examined model predictions in three small fruit production regions in the United States (US) and one in Italy. These production regions have distinctly different climates. In general, patterns of adult D. suzukii trap activity broadly mimicked seasonal population levels predicted by the model using only temperature data. Age structure of estimated populations suggest that trap and fruit infestation data are of limited value and are insufficient for model validation. Thus, we suggest alternative experiments for validation. The model is advantageous in that it provides stage-specific population estimation, which can potentially guide management strategies and provide unique opportunities to simulate stage-specific management effects such as insecticide applications or the effect of biological control on a specific life-stage. The two factors that drive initiation of the model are suitable temperatures (biofix) and availability of a suitable host medium (fruit). Although there are many factors affecting population dynamics of D. suzukii in the field, temperature-dependent survival and reproduction are believed to be the main drivers for D. suzukii populations. PMID:25192013

  9. Differential expression of extracellular matrix remodeling genes in a murine model of bleomycin-induced pulmonary fibrosis.

    PubMed Central

    Swiderski, R. E.; Dencoff, J. E.; Floerchinger, C. S.; Shapiro, S. D.; Hunninghake, G. W.

    1998-01-01

    Exposure to the chemotherapeutic drug bleomycin leads to pulmonary fibrosis in humans and has been widely used in animal models of the disease. Using C57BL/6 bleomycin-sensitive mice, pulmonary fibrosis was induced by multiple intraperitoneal injections of the drug. An increase in the relative amounts of steady-state alpha1(I) procollagen, alpha1(III) procollagen, and fibronectin mRNA as well as histopathological evidence of fibrosis was observed. The effect of bleomycin on the expression of the enzymes responsible for extracellular matrix degradation, the matrix metalloproteinases (MMPs), and their inhibitors (TIMPs), was selective and showed temporal differences during the development of fibrosis. Of the MMPs tested, bleomycin treatment resulted in the up-regulation of gelatinase A and macrophage metalloelastase gene expression in whole-lung homogenates, whereas gelatinase B, stromelysin-1, and interstitial collagenase gene expression was not significantly changed. Timp2 and Timp3, the murine homologues of the respective TIMP genes, were constitutively expressed, whereas Timp1 was markedly up-regulated during fibrosis. The strong correlation between enhanced extracellular matrix gene expression, differential MMP and TIMP gene expression, and histopathological evidence of fibrosis suggest that dysregulated matrix remodeling is likely to contribute to the pathology of bleomycin-induced pulmonary fibrosis. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 PMID:9502424

  10. On implementation of EM-type algorithms in the stochastic models for a matrix computing on GPU

    SciTech Connect

    Gorshenin, Andrey K.

    2015-03-10

    The paper discusses the main ideas of an implementation of EM-type algorithms for computing on the graphics processors and the application for the probabilistic models based on the Cox processes. An example of the GPU’s adapted MATLAB source code for the finite normal mixtures with the expectation-maximization matrix formulas is given. The testing of computational efficiency for GPU vs CPU is illustrated for the different sample sizes.

  11. OOMM--Object-Oriented Matrix Modelling: an instrument for the integration of the Brasilia Regional Health Information System.

    PubMed

    Cammarota, M; Huppes, V; Gaia, S; Degoulet, P

    1998-01-01

    The development of Health Information Systems is widely determined by the establishment of the underlying information models. An Object-Oriented Matrix Model (OOMM) is described which target is to facilitate the integration of the overall health system. The model is based on information modules named micro-databases that are structured in a three-dimensional network: planning, health structures and information systems. The modelling tool has been developed as a layer on top of a relational database system. A visual browser facilitates the development and maintenance of the information model. The modelling approach has been applied to the Brasilia University Hospital since 1991. The extension of the modelling approach to the Brasilia regional health system is considered.

  12. Development of a Subcell Based Modeling Approach for Modeling the Architecturally Dependent Impact Response of Triaxially Braided Polymer Matrix Composites

    NASA Technical Reports Server (NTRS)

    Sorini, Chris; Chattopadhyay, Aditi; Goldberg, Robert K.; Kohlman, Lee W.

    2016-01-01

    Understanding the high velocity impact response of polymer matrix composites with complex architectures is critical to many aerospace applications, including engine fan blade containment systems where the structure must be able to completely contain fan blades in the event of a blade-out. Despite the benefits offered by these materials, the complex nature of textile composites presents a significant challenge for the prediction of deformation and damage under both quasi-static and impact loading conditions. The relatively large mesoscale repeating unit cell (in comparison to the size of structural components) causes the material to behave like a structure rather than a homogeneous material. Impact experiments conducted at NASA Glenn Research Center have shown the damage patterns to be a function of the underlying material architecture. Traditional computational techniques that involve modeling these materials using smeared homogeneous, orthotropic material properties at the macroscale result in simulated damage patterns that are a function of the structural geometry, but not the material architecture. In order to preserve heterogeneity at the highest length scale in a robust yet computationally efficient manner, and capture the architecturally dependent damage patterns, a previously-developed subcell modeling approach where the braided composite unit cell is approximated as a series of four adjacent laminated composites is utilized. This work discusses the implementation of the subcell methodology into the commercial transient dynamic finite element code LS-DYNA (Livermore Software Technology Corp.). Verification and validation studies are also presented, including simulation of the tensile response of straight-sided and notched quasi-static coupons composed of a T700/PR520 triaxially braided [0deg/60deg/-60deg] composite. Based on the results of the verification and validation studies, advantages and limitations of the methodology as well as plans for future work

  13. Long-term performance of ceramic matrix composites at elevated temperatures: Modelling of creep and creep rupture

    SciTech Connect

    Curtin, W.A.; Fabeny, B.; Ibnabdeljalil, M.; Iyengar, N.; Reifsnider, K.L.

    1996-07-31

    The models developed, contain explicit dependences on constituent material properties and their changes with time, so that composite performance can be predicted. Three critical processes in ceramic composites at elevated temperatures have been modeled: (1) creep deformation of composite vs stress and time-dependent creep of fibers and matrix, and failure of these components; (2) creep deformation of ``interface`` around broken fibers; and (3) lifetime of the composite under conditions of fiber strength loss over time at temperature. In (1), general evolution formulas are derived for relaxation time of matrix stresses and steady-state creep rate of composite; the model is tested against recent data on Ti-MMCs. Calculations on a composite of Hi-Nicalon fibers in a melt-infiltrated SiC matrix are presented. In (2), numerical simulations of composite failure were made to map out time-to-failure vs applied load for several sets of material parameters. In (3), simple approximate relations are obtained between fiber life and composite life that should be useful for fiber developers and testers. Strength degradation data on Hi-Nicalon fibers is used to assess composite lifetime vs fiber lifetime for Hi-Nicalon fiber composites.

  14. Modeling of Damage Initiation and Progression in a SiC/SiC Woven Ceramic Matrix Composite

    NASA Technical Reports Server (NTRS)

    Mital, Subodh K.; Goldberg, Robert K.; Bonacuse, Peter J.

    2012-01-01

    The goal of an ongoing project at NASA Glenn is to investigate the effects of the complex microstructure of a woven ceramic matrix composite and its variability on the effective properties and the durability of the material. Detailed analysis of these complex microstructures may provide clues for the material scientists who `design the material? or to structural analysts and designers who `design with the material? regarding damage initiation and damage propagation. A model material system, specifically a five-harness satin weave architecture CVI SiC/SiC composite composed of Sylramic-iBN fibers and a SiC matrix, has been analyzed. Specimens of the material were serially sectioned and polished to capture the detailed images of fiber tows, matrix and porosity. Open source analysis tools were used to isolate various constituents and finite elements models were then generated from simplified models of those images. Detailed finite element analyses were performed that examine how the variability in the local microstructure affected the macroscopic behavior as well as the local damage initiation and progression. Results indicate that the locations where damage initiated and propagated is linked to specific microstructural features.

  15. Hydrolysis of triple-helical collagen peptide models by matrix metalloproteinases.

    PubMed

    Lauer-Fields, J L; Tuzinski, K A; Shimokawa, K i; Nagase, H; Fields, G B

    2000-05-05

    The matrix metalloproteinase (MMP) family has been implicated in the process of a variety of diseases such as arthritis, atherosclerosis, and tumor cell metastasis. To study the mechanisms of MMP action on collagenous substrates, we have constructed homotrimeric triple-helical peptide (THP) models of the collagenase cleavage sites in types I and II collagen. The THPs incorporate either the alpha1(I)772-786 or the alpha1(II)772-783 sequence. The alpha1(I)772-786 and alpha1(II)772-783 THPs were hydrolyzed by MMP-1 at the Gly-Ile and Gly-Leu bonds, respectively, analogous to the bonds cleaved in corresponding native collagens. Thus, the THPs contained all necessary information to direct MMP-1 binding and proteolysis. Subsequent investigations using the alpha1(I)772-786 THP showed hydrolysis by MMP-2, MMP-13, and a COOH-terminal domain-deleted MMP-1 (MMP-1(Delta(243-450))) but not by MMP-3 or a COOH-terminal domain-deleted MMP-3 (MMP-3(Delta(248-460))). Kinetic analyses showed a k(cat)/K(m) value of 1,808 s(-1) m(-1) for MMP-1 hydrolysis of alpha1(I)772-786 THP, approximately 10-fold lower than for type I collagen. The effect is caused primarily by relative K(m) values. MMP-2 and MMP-13 cleaved the THP more rapidly than MMP-1, but MMP-2 cleavage occurred at distinct multiple sites. Comparison of MMP-1 and MMP-1(Delta(243-450)) hydrolysis of alpha1(I)772-786 THP showed that both can cleave a triple-helical substrate with a slightly higher K(m) value for MMP-1(Delta(243-450)). We propose that the COOH-terminal domain of MMPs is necessary for orienting whole, native collagen molecules but may not be necessary for binding to and cleaving a THP. This proposal is consistent with the large distance between the MMP-1 catalytic and COOH-terminal domains observed by three-dimensional structural analysis and supports previous suggestions that the features of the catalytic domain contribute significantly toward enzyme specificity.

  16. Modeling and Analysis of Granite Matrix Pore Structure and Hydraulic Characteristics in 2D and 3D Networks

    NASA Astrophysics Data System (ADS)

    Gvozdik, L.; Polak, M.; Zaruba, J.; Vanecek, M.

    2010-12-01

    A geological environment labeled as a Granite massif represents in terms of groundwater flow and transport a distinct hydrogeological environment from that of sedimentary basins, the characterisation of which is generally more complex and uncertain. Massifs are composed of hard crystalline rocks with the very low effective porosity. Due to their rheological properties such rocks are predisposed to brittle deformation resulting from changes in stress conditions. Our specific research project (Research on the influence of intergrangular porosity on deep geological disposal: geological formations, methodology and the development of measurement apparatus) is focussed on the problem of permeable zones within apparently undisturbed granitic rock matrix. The project including the both laboratory and in-situ tracer tests study migration along and through mineral grains in fresh and altered granite. The objective of the project is to assess whether intergranular porosity is a general characteristic of the granitic rock matrix or subject to significant evolution resulting from geochemical and/or hydrogeochemical processes, geotechnical and/or mechanical processes. Moreover, the research is focussed on evaluating methods quantifying intergranular porosity by both physical testing and mathematical modelling using verified standard hydrological software tools. Groundwater flow in microfractures and intergranular pores in granite rock matrix were simulated in three standard hydrogeological modeling programs with completely different conceptual approaches: MODFLOW (Equivalent Continuum concept), FEFLOW (Discrete Fracture and Equivalent Continuum concepts) and NAPSAC (Discrete Fracture Network concept). Specialized random fracture generators were used for creation of several 2D and 3D models in each of the chosen program. Percolation characteristics of these models were tested and analyzed. Several scenarios of laboratory tests of the rock samples permeability made in triaxial

  17. Probing mechanical principles of focal contacts in cell–matrix adhesion with a coupled stochastic–elastic modelling framework

    PubMed Central

    Gao, Huajian; Qian, Jin; Chen, Bin

    2011-01-01

    Cell–matrix adhesion depends on the collective behaviours of clusters of receptor–ligand bonds called focal contacts between cell and extracellular matrix. While the behaviour of a single molecular bond is governed by statistical mechanics at the molecular scale, continuum mechanics should be valid at a larger scale. This paper presents an overview of a series of recent theoretical studies aimed at probing the basic mechanical principles of focal contacts in cell–matrix adhesion via stochastic–elastic models in which stochastic descriptions of molecular bonds and elastic descriptions of interfacial traction–separation are unified in a single modelling framework. The intention here is to illustrate these principles using simple analytical and numerical models. The aim of the discussions is to provide possible clues to the following questions: why does the size of focal adhesions (FAs) fall into a narrow range around the micrometre scale? How can cells sense and respond to substrates of varied stiffness via FAs? How do the magnitude and orientation of mechanical forces affect the binding dynamics of FAs? The effects of cluster size, cell–matrix elastic modulus, loading direction and cytoskeletal pretension on the lifetime of FA clusters have been investigated by theoretical arguments as well as Monte Carlo numerical simulations, with results showing that intermediate adhesion size, stiff substrate, cytoskeleton stiffening, low-angle pulling and moderate cytoskeletal pretension are factors that contribute to stable FAs. From a mechanistic point of view, these results provide possible explanations for a wide range of experimental observations and suggest multiple mechanisms by which cells can actively control adhesion and de-adhesion via cytoskeletal contractile machinery in response to mechanical properties of their surroundings. PMID:21632610

  18. Gelatin Methacrylate Hydrogels as Biomimetic Three-Dimensional Matrixes for Modeling Breast Cancer Invasion and Chemoresponse in Vitro.

    PubMed

    Arya, Anuradha D; Hallur, Pavan M; Karkisaval, Abhijith G; Gudipati, Aditi; Rajendiran, Satheesh; Dhavale, Vaibhav; Ramachandran, Balaji; Jayaprakash, Aravindakshan; Gundiah, Namrata; Chaubey, Aditya

    2016-08-31

    Recent studies have shown that three-dimensional (3D) culture environments allow the study of cellular responses in a setting that more closely resembles the in vivo milieu. In this context, hydrogels have become popular scaffold options for the 3D cell culture. Because the mechanical and biochemical properties of culture matrixes influence crucial cell behavior, selecting a suitable matrix for replicating in vivo cellular phenotype in vitro is essential for understanding disease progression. Gelatin methacrylate (GelMA) hydrogels have been the focus of much attention because of their inherent bioactivity, favorable hydration and diffusion properties, and ease-of-tailoring of their physicochemical characteristics. Therefore, in this study we examined the efficacy of GelMA hydrogels as a suitable platform to model specific attributes of breast cancer. We observed increased invasiveness in vitro and increased tumorigenic ability in vivo in breast cancer cells cultured on GelMA hydrogels. Further, cells cultured on GelMA matrixes were more resistant to paclitaxel treatment, as shown by the results of cell-cycle analysis and gene expression. This study, therefore, validates GelMA hydrogels as inexpensive, cell-responsive 3D platforms for modeling key characteristics associated with breast cancer metastasis, in vitro.

  19. [The inclusion of nutritionists in Primary Health Care: a proposal for a matrix model of nutritional care].

    PubMed

    Borelli, Marina; Domene, Semíramis Martins Álvares; Mais, Laís Amaral; Pavan, Juliana; Taddei, José Augusto de Aguiar Carrazedo

    2015-09-01

    Nutritionists were integrated into the Family Health Support Centers back in 2008. Focusing on the development of technical and pedagogical support and assistance to Family Health Teams, the aim of this study was to develop a proposal for a matrix model for nutrition aimed at women and children in the Family Health Strategy. The study was conducted in a Basic Health Unit and was divided into Cycle I, including interviews with families of 0 to 6-year-old children to establish the confines of the territory; and Cycles II and III, with the development of intersectorial field activities to promote food and nutritional security based on matrix support. Following the diagnosis of social vulnerability, children's nutritional risk, indicators of early weaning and inadequate food intake, actions were developed in order to propose a matrix model of nutritional measures in three scenarios, namely at the community, family and individual level. Among the activities that were developed, the main ones included cooking classes, prenatal care, and the training of Community Health Agents. This study tested ways to develop nutritional care by broadened clinical action and territory recognition, seeking to enhance the activities of nutritionists as health educators.

  20. The Bottlenose Dolphin (Tursiops truncatus) as a Model to Understand Variation in Stress and Reproductive Hormone Measures in Relation to Sampling Matrix, Demographics, and Environmental Factors

    DTIC Science & Technology

    2014-09-30

    Understand Variation in Stress and Reproductive Hormone Measures in Relation to Sampling Matrix, Demographics, and Environmental Factors...GC hormones can lead to chronic immune suppression and inhibition of other energy-expending hormonal systems, including disruption of reproductive ...truncatus) as a Model to Understand Variation in Stress and Reproductive Hormone Measures in Relation to Sampling Matrix, Demographics, and

  1. Matrixed business support comparison study.

    SciTech Connect

    Parsons, Josh D.

    2004-11-01

    The Matrixed Business Support Comparison Study reviewed the current matrixed Chief Financial Officer (CFO) division staff models at Sandia National Laboratories. There were two primary drivers of this analysis: (1) the increasing number of financial staff matrixed to mission customers and (2) the desire to further understand the matrix process and the opportunities and challenges it creates.

  2. Mechanical characterization and modeling of non-linear deformation and fracture of a fiber reinforced metal matrix composite

    NASA Technical Reports Server (NTRS)

    Jansson, S.

    1991-01-01

    The nonlinear anisotropic mechanical behavior of an aluminum alloy metal matrix composite reinforced with continuous alumina fibers was determined experimentally. The mechanical behavior of the composite were modeled by assuming that the composite has a periodical microstructure. The resulting unit cell problem was solved with the finite element method. Excellent agreement was found between theoretically predicted and measured stress-strain responses for various tensile and shear loadings. The stress-strain responses for transverse and inplane shear were found to be identical and this will provide a simplification of the constitutive equations for the composite. The composite has a very low ductility in transverse tension and a limited ductility in transverse shear that was correlated to high hydrostatic stresses that develop in the matrix. The shape of the initial yield surface was calculated and good agreement was found between the calculated shape and the experimentally determined shape.

  3. Concomitant use of the matrix strategy and the mand-model procedure in teaching graphic symbol combinations.

    PubMed

    Nigam, Ravi; Schlosser, Ralf W; Lloyd, Lyle L

    2006-09-01

    Matrix strategies employing parts of speech arranged in systematic language matrices and milieu language teaching strategies have been successfully used to teach word combining skills to children who have cognitive disabilities and some functional speech. The present study investigated the acquisition and generalized production of two-term semantic relationships in a new population using new types of symbols. Three children with cognitive disabilities and little or no functional speech were taught to combine graphic symbols. The matrix strategy and the mand-model procedure were used concomitantly as intervention procedures. A multiple probe design across sets of action-object combinations with generalization probes of untrained combinations was used to teach the production of graphic symbol combinations. Results indicated that two of the three children learned the early syntactic-semantic rule of combining action-object symbols and demonstrated generalization to untrained action-object combinations and generalization across trainers. The results and future directions for research are discussed.

  4. Quantitative analysis of ultrasonic images of fibrotic liver using co-occurrence matrix based on multi-Rayleigh model

    NASA Astrophysics Data System (ADS)

    Isono, Hiroshi; Hirata, Shinnosuke; Hachiya, Hiroyuki

    2015-07-01

    In medical ultrasonic images of liver disease, a texture with a speckle pattern indicates a microscopic structure such as nodules surrounded by fibrous tissues in hepatitis or cirrhosis. We have been applying texture analysis based on a co-occurrence matrix to ultrasonic images of fibrotic liver for quantitative tissue characterization. A co-occurrence matrix consists of the probability distribution of brightness of pixel pairs specified with spatial parameters and gives new information on liver disease. Ultrasonic images of different types of fibrotic liver were simulated and the texture-feature contrast was calculated to quantify the co-occurrence matrices generated from the images. The results show that the contrast converges with a value that can be theoretically estimated using a multi-Rayleigh model of echo signal amplitude distribution. We also found that the contrast value increases as liver fibrosis progresses and fluctuates depending on the size of fibrotic structure.

  5. Suprathel-antiseptic matrix: in vitro model for local antiseptic treatment?

    PubMed

    Ryssel, Henning; Andreas Radu, Christian; Germann, Guenter; Kloeters, Oliver; Riedel, Katrin; Otte, Maximilian; Kremer, Thomas

    2011-02-01

    Acetic acid is a traditional antiseptic agent that has been used for more than 6000 years. The main goal of this study was to demonstrate the suitability of Suprathel (PolyMedics Innovations GmbH, Denkendorf, Germany) in combination with various antiseptic agents to create an "antiseptic-matrix" especially designed for problematic microorganisms such as Proteus vulgaris, Acinetobacter baumannii, or Pseudomonas aeruginosa, which are frequently associated with burns. The study was designed to test the in vitro antimicrobial effect of a "Suprathel-antiseptic matrix" (Suprathel combined with acetic acid 3%, povidone-iodine 11% [Betaisodona], polyhexanide 0.04% [Lavasept], phenoxyethanol 2%/octenidine dihydrochloride 0.1% [Octenisept], mafenide acetate 5%, and chlorhexidine gluconate 1.5%/cetrimid 15% [Hibicet]). As a means to assess the typical bacterial spectrum of a burn unit, the following Gram-negative and Gram-positive bacteria strains were tested: Escherichia coli, P vulgaris, P aeruginosa, A baumannii, Enterococcus faecalis, Staphylococcus epidermidis, Staphylococcus aureus, methicillin-resistant S aureus, and β-hemolytic streptococcus groups A and B. The tests showed a positive bactericidal effect of the Suprathel-antiseptic matrix, particularly with problematic Gram-negative bacteria such as P vulgaris, P aeruginosa, and A baumannii, except for the combination of Suprathel and mafenide acetate. It can be concluded that Suprathel-antiseptic matrix appears to be suitable as a local antiseptic agent, but clinical studies need to be performed to confirm these in vitro observations. The authors' previous studies have shown that acetic acid demonstrates a wide antiseptic spectrum for microorganisms typically found in burn patients. The combination of Suprathel and acetic acid worked well in this study and appears to be promising for future clinical application.

  6. Model system for studies on bone matrix formation by osteogenic cells in microgravity

    NASA Astrophysics Data System (ADS)

    Quinton, Todd M.; Fattaey, Heideh K.; Motaffaf, Farzaneh; Johnson, Terry C.

    1998-01-01

    A considerable amount of attention has been focused on the physiological factors that are responsible for the reduction of bone mineralization and mass during prolonged periods in the microgravity environment. Although bone mineralization can be reduced by one percent per month as shown to result from shuttle flights and Mir habitation, the reasons for this phenomenon remain unclear. Changes in specific markers of bone cells upon differentiation indicate that the induction of bone matrix formation is dependent upon these cells reaching confluency. In our laboratory, we have isolated a reversible inhibitor of cellular growth (CeReS-18) that could be important in cell contact inhibition and thus may mimic the signals involved in growth confluency. Preliminary experiments with osteogenic cells have revealed the potential capability of CeReS-18 to inhibit these cells in a reversible manner. We are developing a series of studies, designed at the cellular level, to quantitatively measure the production of bone matrix by osteogenic cells propagated in culture. The use of CeReS-18 would facilitate the study of several factors being assessed regarding matrix formation including the rate of cell population density, hormone induction events, calcium availability, and cell cycle arest. The studies are being conducted in a manner that will allow comparable measurements in the microgravity environment with flight hardware designed and deployed by BioServe Space Technologies.

  7. A numerical model for predicting crack path and modes of damage in unidirectional metal matrix composites

    NASA Technical Reports Server (NTRS)

    Bakuckas, J. G.; Tan, T. M.; Lau, A. C. W.; Awerbuch, J.

    1993-01-01

    A finite element-based numerical technique has been developed to simulate damage growth in unidirectional composites. This technique incorporates elastic-plastic analysis, micromechanics analysis, failure criteria, and a node splitting and node force relaxation algorithm to create crack surfaces. Any combination of fiber and matrix properties can be used. One of the salient features of this technique is that damage growth can be simulated without pre-specifying a crack path. In addition, multiple damage mechanisms in the forms of matrix cracking, fiber breakage, fiber-matrix debonding and plastic deformation are capable of occurring simultaneously. The prevailing failure mechanism and the damage (crack) growth direction are dictated by the instantaneous near-tip stress and strain fields. Once the failure mechanism and crack direction are determined, the crack is advanced via the node splitting and node force relaxation algorithm. Simulations of the damage growth process in center-slit boron/aluminum and silicon carbide/titanium unidirectional specimens were performed. The simulation results agreed quite well with the experimental observations.

  8. 3D model of a matrix source of negative ions: RF driving by a large area planar coil

    NASA Astrophysics Data System (ADS)

    Demerdzhiev, A.; Lishev, St.; Tarnev, Kh.; Shivarova, A.

    2015-04-01

    Based on three-dimensional (3D) modeling, different manners of a planar-coil inductive discharge driving of a plasma source completed as a matrix of small-radius hydrogen discharges are studied regarding a proper choice of an efficient and alike rf power deposition into the separate discharges of the matrix. Driving the whole matrix by a single coil and splitting it to blocks of discharge tubes, with single coil driving of each block, are the two cases considered. The results from the self-consistent model presented for a block of discharge tubes show its reliability in ensuring the same spatial distribution of the plasma parameters in the discharges completing the block. Since regarding the construction of the matrix, its driving as a whole by a single coil is the most reasonable decision, three modifications of the coil design have been tested: two zigzag coils with straight conductors passing, respectively, between and through the bottoms of the discharge tubes and a coil with an "omega" shaped conductor on the bottom of each tube. Among these three configurations, the latter ‒ a coil with an Ω-shaped conductor on the bottom of each tube ‒ shows up with the highest rf efficiency of an inductive discharge driving, shown by results for the rf current induced in the discharges obtained from an electrodynamical description. In all the cases considered the spatial distribution of the induced current density is analysed based on the manner of the penetration into the plasma of the wave field sustaining the inductive discharges.

  9. On the Numerical Formulation of Parametric Linear Fractional Transformation (LFT) Uncertainty Models for Multivariate Matrix Polynomial Problems

    NASA Technical Reports Server (NTRS)

    Belcastro, Christine M.

    1998-01-01

    Robust control system analysis and design is based on an uncertainty description, called a linear fractional transformation (LFT), which separates the uncertain (or varying) part of the system from the nominal system. These models are also useful in the design of gain-scheduled control systems based on Linear Parameter Varying (LPV) methods. Low-order LFT models are difficult to form for problems involving nonlinear parameter variations. This paper presents a numerical computational method for constructing and LFT model for a given LPV model. The method is developed for multivariate polynomial problems, and uses simple matrix computations to obtain an exact low-order LFT representation of the given LPV system without the use of model reduction. Although the method is developed for multivariate polynomial problems, multivariate rational problems can also be solved using this method by reformulating the rational problem into a polynomial form.

  10. Fast-SNP: a fast matrix pre-processing algorithm for efficient loopless flux optimization of metabolic models

    PubMed Central

    Saa, Pedro A.; Nielsen, Lars K.

    2016-01-01

    Motivation: Computation of steady-state flux solutions in large metabolic models is routinely performed using flux balance analysis based on a simple LP (Linear Programming) formulation. A minimal requirement for thermodynamic feasibility of the flux solution is the absence of internal loops, which are enforced using ‘loopless constraints’. The resulting loopless flux problem is a substantially harder MILP (Mixed Integer Linear Programming) problem, which is computationally expensive for large metabolic models. Results: We developed a pre-processing algorithm that significantly reduces the size of the original loopless problem into an easier and equivalent MILP problem. The pre-processing step employs a fast matrix sparsification algorithm—Fast- sparse null-space pursuit (SNP)—inspired by recent results on SNP. By finding a reduced feasible ‘loop-law’ matrix subject to known directionalities, Fast-SNP considerably improves the computational efficiency in several metabolic models running different loopless optimization problems. Furthermore, analysis of the topology encoded in the reduced loop matrix enabled identification of key directional constraints for the potential permanent elimination of infeasible loops in the underlying model. Overall, Fast-SNP is an effective and simple algorithm for efficient formulation of loop-law constraints, making loopless flux optimization feasible and numerically tractable at large scale. Availability and Implementation: Source code for MATLAB including examples is freely available for download at http://www.aibn.uq.edu.au/cssb-resources under Software. Optimization uses Gurobi, CPLEX or GLPK (the latter is included with the algorithm). Contact: lars.nielsen@uq.edu.au Supplementary information: Supplementary data are available at Bioinformatics online. PMID:27559155

  11. An analytical/numerical correlation study of the multiple concentric cylinder model for the thermoplastic response of metal matrix composites

    NASA Technical Reports Server (NTRS)

    Pindera, Marek-Jerzy; Salzar, Robert S.; Williams, Todd O.

    1993-01-01

    The utility of a recently developed analytical micromechanics model for the response of metal matrix composites under thermal loading is illustrated by comparison with the results generated using the finite-element approach. The model is based on the concentric cylinder assemblage consisting of an arbitrary number of elastic or elastoplastic sublayers with isotropic or orthotropic, temperature-dependent properties. The elastoplastic boundary-value problem of an arbitrarily layered concentric cylinder is solved using the local/global stiffness matrix formulation (originally developed for elastic layered media) and Mendelson's iterative technique of successive elastic solutions. These features of the model facilitate efficient investigation of the effects of various microstructural details, such as functionally graded architectures of interfacial layers, on the evolution of residual stresses during cool down. The available closed-form expressions for the field variables can readily be incorporated into an optimization algorithm in order to efficiently identify optimal configurations of graded interfaces for given applications. Comparison of residual stress distributions after cool down generated using finite-element analysis and the present micromechanics model for four composite systems with substantially different temperature-dependent elastic, plastic, and thermal properties illustrates the efficacy of the developed analytical scheme.

  12. Evaluation of the Majorana phases of a general Majorana neutrino mass matrix: Testability of hierarchical flavour models

    NASA Astrophysics Data System (ADS)

    Samanta, Rome; Chakraborty, Mainak; Ghosal, Ambar

    2016-03-01

    We evaluate the Majorana phases for a general 3 × 3 complex symmetric neutrino mass matrix on the basis of Mohapatra-Rodejohann's phase convention using the three rephasing invariant quantities I12, I13 and I23 proposed by Sarkar and Singh. We find them interesting as they allow us to evaluate each Majorana phase in a model independent way even if one eigenvalue is zero. Utilizing the solution of a general complex symmetric mass matrix for eigenvalues and mixing angles we determine the Majorana phases for both the hierarchies, normal and inverted, taking into account the constraints from neutrino oscillation global fit data as well as bound on the sum of the three light neutrino masses (Σimi) and the neutrinoless double beta decay (ββ0ν) parameter |m11 |. This methodology of finding the Majorana phases is applied thereafter in some predictive models for both the hierarchical cases (normal and inverted) to evaluate the corresponding Majorana phases and it is shown that all the sub cases presented in inverted hierarchy section can be realized in a model with texture zeros and scaling ansatz within the framework of inverse seesaw although one of the sub cases following the normal hierarchy is yet to be established. Except the case of quasi degenerate neutrinos, the methodology obtained in this work is able to evaluate the corresponding Majorana phases, given any model of neutrino masses.

  13. Fourier transform infrared spectroscopy to quantify collagen and elastin in an in vitro model of extracellular matrix degradation in aorta.

    PubMed

    Cheheltani, Rabee; McGoverin, Cushla M; Rao, Jayashree; Vorp, David A; Kiani, Mohammad F; Pleshko, Nancy

    2014-06-21

    Extracellular matrix (ECM) is a key component and regulator of many biological tissues including aorta. Several aortic pathologies are associated with significant changes in the composition of the matrix, especially in the content, quality and type of aortic structural proteins, collagen and elastin. The purpose of this study was to develop an infrared spectroscopic methodology that is comparable to biochemical assays to quantify collagen and elastin in aorta. Enzymatically degraded porcine aorta samples were used as a model of ECM degradation in abdominal aortic aneurysm (AAA). After enzymatic treatment, Fourier transform infrared (FTIR) spectra of the aortic tissue were acquired by an infrared fiber optic probe (IFOP) and FTIR imaging spectroscopy (FT-IRIS). Collagen and elastin content were quantified biochemically and partial least squares (PLS) models were developed to predict collagen and elastin content in aorta based on FTIR spectra. PLS models developed from FT-IRIS spectra were able to predict elastin and collagen content of the samples with strong correlations (RMSE of validation = 8.4% and 11.1% of the range respectively), and IFOP spectra were successfully used to predict elastin content (RMSE = 11.3% of the range). The PLS regression coefficients from the FT-IRIS models were used to map collagen and elastin in tissue sections of degraded porcine aortic tissue as well as a human AAA biopsy tissue, creating a similar map of each component compared to histology. These results support further application of FTIR spectroscopic techniques for evaluation of AAA tissues.

  14. Fourier Transform Infrared Spectroscopy to Quantify Collagen and Elastin in an In Vitro Model of Extracellular Matrix Degradation in Aorta

    PubMed Central

    Cheheltani, Rabee; McGoverin, Cushla M.; Rao, Jayashree; Vorp, David A.; Kiani, Mohammad F.; Pleshko, N.

    2014-01-01

    Extracellular matrix (ECM) is a key component and regulator of many biological tissues including aorta. Several aortic pathologies are associated with significant changes in the composition of the matrix, especially in the content, quality and type of aortic structural proteins, collagen and elastin. The purpose of this study was to develop an infrared spectroscopic methodology that is comparable to biochemical assays to quantify collagen and elastin in aorta. Enzymatically degraded porcine aorta samples were used as a model of ECM degradation in abdominal aortic aneurysm (AAA). After enzymatic treatment, Fourier transform infrared (FTIR) spectra of the aortic tissue were acquired by an infrared fiber optic probe (IFOP) and FTIR imaging spectroscopy (FT-IRIS). Collagen and elastin content were quantified biochemically and partial least squares (PLS) models were developed to predict collagen and elastin content in aorta based on FTIR spectra. PLS models developed from FT-IRIS spectra were able to predict elastin and collagen content of the samples with strong correlations (RMSE of validation = 8.4% and 11.1% of the range respectively), and IFOP spectra were successfully used to predict elastin content (RMSE = 11.3% of the range). The PLS regression coefficients from the FT-IRIS models were used to map collagen and elastin in tissue sections of degraded porcine aortic tissue as well as a human AAA biopsy tissue, creating a similar map of each component compared to histology. These results support further application of FTIR spectroscopic techniques for evaluation of AAA tissues. PMID:24761431

  15. Intact pericellular matrix of articular cartilage is required for unactivated discoidin domain receptor 2 in the mouse model.

    PubMed

    Xu, Lin; Polur, Ilona; Servais, Jacqueline M; Hsieh, Sirena; Lee, Peter L; Goldring, Mary B; Li, Yefu

    2011-09-01

    Increased expression of the discoidin domain receptor 2 (DDR2) results from its interaction with collagen type II. This induces expression of matrix metalloproteinase (MMP)-13, leading to osteoarthritis (OA). To investigate the impact of the pericellular matrix of chondrocytes on DDR2, we generated a mouse model with inducible overexpression of DDR2 in cartilage. Conditional overexpression of DDR2 in mature mouse articular cartilage was controlled via the cartilage oligomeric matrix protein promoter using the Tet-Off-inducible system. Doxycycline was withdrawn at 1 month of age, and knee joints were examined at 2, 3, and 4 months of age. Microsurgery was performed on 3-month-old transgenic mice overexpressing DDR2 to destabilize the medial meniscus, and serial paraffin sections were examined at 2, 4, 8, and 12 weeks after surgery. DDR2 expression increased in the knee joints of transgenic mice. However, the increased DDR2 did not induce MMP-13 expression. No OA-like changes were observed in the transgenic mice at the age of 4 months. When transgenic mice were subjected to destabilizing of the medial meniscus, we observed accelerated progression to OA, which was associated with DDR2 activation. Therefore, conditionally overexpressing DDR2 in the mature articular cartilage of mouse knee joints requires activation to induce OA, and altered biomechanical stress can accelerate the onset of cartilage loss and progression to OA in transgenic mice.

  16. A Computational Efficient Physics Based Methodology for Modeling Ceramic Matrix Composites (Preprint)

    DTIC Science & Technology

    2011-11-01

    been integrated with the commercial finite element code ABAQUS for analysis of layered polymer matrix composites and is extended here for application... Python ). The format was chosen for its flexibility and shallow learning curve. Prior knowledge of XML is not required to use the software. A...and R. Raj 2002. “Mechanical Properties Of A Fully Dense Polymer Derived Ceramic Made By A Novel Pressure Casting Process,” Acta Materialia, 50(16): 4093-4103. 15 Approved for public release; distribution unlimited.

  17. Modeling neural differentiation on micropatterned substrates coated with neural matrix components

    PubMed Central

    García-Parra, Patricia; Cavaliere, Fabio; Maroto, Marcos; Bilbao, Leire; Obieta, Isabel; López de Munain, Adolfo; Álava, José Iñaki; Izeta, Ander

    2012-01-01

    Topographical and biochemical characteristics of the substrate are critical for neuronal differentiation including axonal outgrowth and regeneration of neural circuits in vivo. Contact stimuli and signaling molecules allow neurons to develop and stabilize synaptic contacts. Here we present the development, characterization and functional validation of a new polymeric support able to induce neuronal differentiation in both PC12 cell line and adult primary skin-derived precursor cells (SKPs) in vitro. By combining a photolithographic technique with use of neural extracellular matrix (ECM) as a substrate, a biocompatible and efficient microenvironment for neuronal differentiation was developed. PMID:22435050

  18. Sucrose stearate-enriched lipid matrix tablets of etodolac: modulation of drug release, diffusional modeling and structure elucidation studies.

    PubMed

    Abd-Elbary, Ahmed; Tadros, Mina Ibrahim; Alaa-Eldin, Ahmed Adel

    2013-06-01

    Etodolac is a non-steroidal anti-inflammatory drug having an elimination half-life of 7 h; oral doses are given every 6-8 h. The aim of current work was the development of controlled-release etodolac lipid matrix tablets. The variables influencing design of these tablets (L1-L28) by the hot fusion method were investigated including; (1) lipid type (stearic acid, cetyl alcohol, cetostearyl alcohol, Imwitor® 900K, Precirol® ATO 5 and Compritol® ATO 888), (2) drug/lipid ratio (1:0.25 and 1:0.50, respectively), (3) filler type (lactose, Avicel® PH101 and their physical mixtures; 2:1, 1:1, and 1:2, respectively), (4) surfactant's HLB (5 and 11), and (5) drug/surfactant ratio (20:1 and 10:1, respectively). Statistical analysis and kinetic modeling of drug release data were evaluated. The inner matrix of the tablet was visualized via scanning electron microscopy (SEM). An inverse correlation was observed between the drug/lipid ratio and the drug release rate. Precirol®- and Compritol®-containing formulae showed more retarded drug release rates. Lactose/Avicel® physical mixture (1:1) was considered as a filler of choice where it minimized the burst effect observed with Avicel®-free formulae. The higher surfactant's HLB, the higher drug release rate. The similarity factor (f(2)) between the drug release profiles revealed similarity within the investigated drug/surfactant ratios. Sucrose stearate D1805®-based matrix (L21) succeeded in delivering more than 90% of etodolac over 12 h, following anomalous (non-Fickian) controlled-release kinetics. SEM micrographs confirmed pore formation, within the latter matrix, upon contact with dissolution medium.

  19. Pericellular Matrix Mechanics in the Anulus Fibrosus Predicted by a Three-Dimensional Finite Element Model and In Situ Morphology

    PubMed Central

    Cao, Li; Guilak, Farshid; Setton, Lori A.

    2009-01-01

    Anulus fibrosus (AF) cells have been demonstrated to exhibit dramatic differences in morphology and biologic responses to different types of mechanical stimuli. AF cells may reside as single cell, paired or multiple cells in a contiguous pericellular matrix (PCM), whose structure and properties are expected to have a significant influence on the mechanical stimuli that these cells may experience during physiologic loading of the spine, as well as in tissue degeneration and regeneration. In this study, a computational model was developed to predict the micromechanical stimuli, such as stress and strain, fluid pressure and flow, of cells and their surrounding PCM in the AF tissue using three-dimensional (3D) finite element models based on in situ morphology. 3D solid geometries of cell-PCM regions were registered from serial confocal images obtained from mature rat AF tissues by custom codes. Distinct cell-matrix units were modeled with a custom 3D biphasic finite element code (COMSOL Multiphysics), and simulated to experience uni-axial tensile strain along the local collagen fiber direction. AF cells were predicted to experience higher volumetric strain with a strain amplification ratio (relative to that in the extracellular matrix) of ~ 3.1 – 3.8 at equilibrium, as compared to the PCM domains (1.3 – 1.9). The strain concentrations were generally found at the cell/PCM interface and stress concentration at the PCM/ECM interface. Increased numbers of cells within a contiguous PCM was associated with an apparent increase of strain levels and decreased rate of fluid pressurization in the cell, with magnitudes dependent on the cell size, shape and relative position inside the PCM. These studies provide spatio-temporal information on micromechanics of AF cells in understanding the mechanotransduction in the intervertebral disc. PMID:19946619

  20. Predictive model for microcracking and mechanical properties of polymer-matrix composite materials for space applications

    NASA Astrophysics Data System (ADS)

    Issoupov, V.; Viel-Inguimbert, V.; Dinguirard, M.; Startsev, O. V.; Nikishin, E. F.

    2003-09-01

    Thermal ageing of polymer-matrix composite materials of any long-life spacecraft in LEO involves evolution of mechanical, thermophysical and morphological properties, especially if the structure operates under external mechanical stress like bending. Behavior of KMU-4l carbon/epoxy composite material under combined effect of thermal profiles and static mechanical loading has been studied in a simulated LEO space environment. Thermal cycling was performed on specimens under bending stress reaching 30.4% of the material ultimate strength. Specimens subjected to combined thermal and mechanical fatigue were examined in a series of 4 intermediate points with a maximum of 120 cycles. The DMTA technique has been employed to follow the global thermomechanical response of KMU-4l composite. The degradation produced was detected by moisture diffusion analysis, the crack density was estimated at the edges of the specimens using a scanning electron microscope. Effects such as the temperature dependence of material properties and matrix post-curing phenomena are also discussed. The results are compared with the appropriate data obtained on specimens of KMU-4l exposed for up to 1501 days to LEO space environments onboard SALYUT and MIR space stations.

  1. Performance and modeling of active metal-matrix composites manufactured by ultrasonic additive manufacturing

    NASA Astrophysics Data System (ADS)

    Hahnlen, Ryan; Dapino, Marcelo J.

    2011-04-01

    This paper presents the development and characterization of active aluminum-matrix composites manufactured by Ultrasonic Additive Manufacturing (UAM), an emerging rapid prototyping process based on ultrasonic metal welding. The primary benefit of UAM over other metal-matrix fabrication processes is the low process temperatures, as low as 25 °C. UAM thus provides unprecedented opportunities to develop adaptive structures with seamlessly embedded smart materials and electronic components without degrading the properties that make these materials and components attractive. The objective of this research is to develop UAM composites with aluminum matrices and embedded shape memory NiTi, magnetostrictive Galfenol (FeGa), and polyvinylidene fluoride (PVDF) phases. The paper is focused on the thermally induced strain response and stiffness behavior of NiTi-Al composites, the actuation properties of FeGa-Al composites, and the embedded sensing capabilities of PVDF-Al composites. We observe up to a 10% increase over room temperature stiffness for NiTi-Al composites and a magnetomechanical response in the FeGa-Al composite up to 52.4 μɛ. The response of the PVDF-Al composite to harmonic loads is observed over a frequency range of 10 to 1000 Hz.

  2. [On the competition among discrete-structured populations: a matrix model for population dynamics of woodreed and birch growing together].

    PubMed

    Ulanova, N G; Belova, I N; Logofet, D O

    2008-01-01

    Presented is a synthesis of field, theoretical and modelling studies on joint dynamics of two species--common birch (Betula pendula Roth) and wood small reed (Calamagrostis epigeios (L.) Roth)--overgrowing a spruce forest clear-cut. A nonlinear matrix model for population dynamics of two species, which both possess non-trivial population structures and compete for a resource in common was developed as an expansion of the linear models for single-species, age-stage-structured population dynamics. Constant values of the age-stage-specific survival and reproduction rates have been modified with some decreasing functions of the (competitive group) abundances in the competitor species or/and the species itself. Special aggregation of the age-stage structure for each of the competitor species has reduced the dimension of the nonlinear matrix operator down to the level that admits accurate calibration of the model parameters on the observation data, as well as the search for an equilibrium and its stability analysis. When calibrated, the nonlinear model exhibits convergence to the steady equilibrium--a state of the phytocoenosis that is interpreted as young, closed-canopy, birch forest with suppressed woodreed population. The model illustrates the observed course of forest renewal: the appearance of birch germs and the growth of birch population overpass the woodreed competitive resistance and result in formation of young birch forest, where the birch exerts a strong suppressive impact on both the woodreed growth and the own young growth. Remarked is a potential of the model as an object of more general mathematical study and a tool to predict the course of forest renewal.

  3. Misleading Population Estimates: Biases and Consistency of Visual Surveys and Matrix Modelling in the Endangered Bearded Vulture

    PubMed Central

    Margalida, Antoni; Oro, Daniel; Cortés-Avizanda, Ainara; Heredia, Rafael; Donázar, José A.

    2011-01-01

    Conservation strategies for long-lived vertebrates require accurate estimates of parameters relative to the populations' size, numbers of non-breeding individuals (the “cryptic” fraction of the population) and the age structure. Frequently, visual survey techniques are used to make these estimates but the accuracy of these approaches is questionable, mainly because of the existence of numerous potential biases. Here we compare data on population trends and age structure in a bearded vulture (Gypaetus barbatus) population from visual surveys performed at supplementary feeding stations with data derived from population matrix-modelling approximations. Our results suggest that visual surveys overestimate the number of immature (<2 years old) birds, whereas subadults (3–5 y.o.) and adults (>6 y.o.) were underestimated in comparison with the predictions of a population model using a stable-age distribution. In addition, we found that visual surveys did not provide conclusive information on true variations in the size of the focal population. Our results suggest that although long-term studies (i.e. population matrix modelling based on capture-recapture procedures) are a more time-consuming method, they provide more reliable and robust estimates of population parameters needed in designing and applying conservation strategies. The findings shown here are likely transferable to the management and conservation of other long-lived vertebrate populations that share similar life-history traits and ecological requirements. PMID:22039550

  4. A Leslie matrix model for Sicyopterus lagocephalus in La Réunion: sensitivity, uncertainty and research prioritization.

    PubMed

    Artzrouni, Marc; Teichert, Nils; Mara, Thierry

    2014-10-01

    We propose a Leslie matrix model for the population dynamics of Sicyopterus lagocephalus in La Réunion. In order to capture both the amphidromous and the seasonal natures of the species' life history the model has four stages (sea+three river sites) and is cyclical with a 12 month period. Baseline parameters (age-specific fecundity, spatial dispersion patterns and survival rates) were chosen in such a way that the dominant eigenvalue of the year-on-year projection matrix is 1. Large uncertainties on the parameter values preclude the use of the model for management purpose. A sensitivity/uncertainty analysis sheds light on the parameters that cause much of the output to vary and that are poorly known: the life expectancy in rivers and the mortality both at river mouths and during the drift of larvae to sea. The aim is to help policymakers and researchers prioritize data acquisition efforts. The ultimate goal is a sustainable management of Sicyopterus lagocephalus in La Réunion.

  5. Genomic analysis of a spontaneous model of breast cancer metastasis to bone reveals a role for the extracellular matrix.

    PubMed

    Eckhardt, Bedrich L; Parker, Belinda S; van Laar, Ryan K; Restall, Christina M; Natoli, Anthony L; Tavaria, Michael D; Stanley, Kym L; Sloan, Erica K; Moseley, Jane M; Anderson, Robin L

    2005-01-01

    A clinically relevant model of spontaneous breast cancer metastasis to multiple sites, including bone, was characterized and used to identify genes involved in metastatic progression. The metastatic potential of several genetically related tumor lines was assayed using a novel real-time quantitative RT-PCR assay of tumor burden. Based on this assay, the tumor lines were categorized as nonmetastatic (67NR), weakly metastatic to lymph node (168FARN) or lung (66cl4), or highly metastatic to lymph node, lung, and bone (4T1.2 and 4T1.13). In vitro assays that mimic stages of metastasis showed that highly metastatic tumors lines were more adhesive, invasive, and migratory than the less metastatic lines. To identify metastasis-related genes in this model, each metastatic tumor was array profiled against the nonmetastatic 67NR using 15,000 mouse cDNA arrays. A significant proportion of genes relating to the extracellular matrix had elevated expression in highly metastatic tumors. The role of one of these genes, POEM, was further investigated in the model. In situ hybridization showed that POEM expression was specific to the tumor epithelium of highly metastatic tumors. Decreased POEM expression in 4T1.2 tumors significantly inhibited spontaneous metastasis to the lung, bone, and kidney. Taken together, our data support a role for the extracellular matrix in metastatic progression and describe, for the first time, a role for POEM in this process.

  6. Efficient fully 3D list-mode TOF PET image reconstruction using a factorized system matrix with an image domain resolution model

    PubMed Central

    Zhou, Jian; Qi, Jinyi

    2014-01-01

    A factorized system matrix utilizing an image domain resolution model is attractive in fully 3D TOF PET image reconstruction using list-mode data. In this paper, we study a factored model based on sparse matrix factorization that is comprised primarily of a simplified geometrical projection matrix and an image blurring matrix. Beside the commonly-used Siddon's raytracer, we propose another more simplified geometrical projector based on the Bresenham's raytracer which further reduces the computational cost. We discuss in general how to obtain an image blurring matrix associated with a geometrical projector, and provide theoretical analysis that can be used to inspect the efficiency in model factorization. In simulation studies, we investigate the performance of the proposed sparse factorization model in terms of spatial resolution, noise properties and computational cost. The quantitative results reveal that the factorization model can be as efficient as a nonfactored model such as the analytical model while its computational cost can be much lower. In addition we conduct Monte Carlo simulations to identify the conditions under which the image resolution model can become more efficient in terms of image contrast recovery. We verify our observations using the provided theoretical analysis. The result offers a general guide to achieve optimal reconstruction performance based on a sparse factorization model with an only image domain resolution model. PMID:24434568

  7. Expanding (3+1)-dimensional universe from a lorentzian matrix model for superstring theory in (9+1) dimensions.

    PubMed

    Kim, Sang-Woo; Nishimura, Jun; Tsuchiya, Asato

    2012-01-06

    We reconsider the matrix model formulation of type IIB superstring theory in (9+1)-dimensional space-time. Unlike the previous works in which the Wick rotation was used to make the model well defined, we regularize the Lorentzian model by introducing infrared cutoffs in both the spatial and temporal directions. Monte Carlo studies reveal that the two cutoffs can be removed in the large-N limit and that the theory thus obtained has no parameters other than one scale parameter. Moreover, we find that three out of nine spatial directions start to expand at some "critical time," after which the space has SO(3) symmetry instead of SO(9).

  8. A unified multicomponent stress-diffusion model of drug release from non-biodegradable polymeric matrix tablets.

    PubMed

    Salehi, Ali; Zhao, Jin; Cabelka, Tim D; Larson, Ronald G

    2016-02-28

    We propose a new transport model of drug release from hydrophilic polymeric matrices, based on Stefan-Maxwell flux laws for multicomponent transport. Polymer stress is incorporated in the total mixing free energy, which contributes directly to the diffusion driving force while leading to time-dependent boundary conditions at the tablet interface. Given that hydrated matrix tablets are dense multicomponent systems, extended Stefan-Maxwell (ESM) flux laws are adopted to ensure consistency with the Onsager reciprocity principle and the Gibbs-Duhem thermodynamic constraint. The ESM flux law for any given component takes into account the friction exerted by all other species and is invariant with respect to reference velocity, thus satisfying Galilean translational invariance. Our model demonstrates that penetrant-induced plasticization of polymer chains partially or even entirely offsets the steady decline of chemical potential gradients at the tablet-medium interface that drive drug release. Utilizing a Flory-Huggins thermodynamic model, a modified form of the upper convected Maxwell constitutive equation for polymer stress and a Fujita-type dependence of mutual diffusivities on composition, depending on parameters, Fickian, anomalous or case II drug transport arises naturally from the model, which are characterized by quasi-power-law release profiles with exponents ranging from 0.5 to 1, respectively. A necessary requirement for non-Fickian release in our model is that the matrix stress relaxation time is comparable to the time scale for water diffusion. Mutual diffusivities and their composition dependence are the most decisive factors in controlling drug release characteristics in our model. Regression of the experimental polymer dissolution and drug release profiles in a system of Theophylline/cellulose (K15M) demonstrate that API-water mutual diffusivity in the presence of excipient cannot generally be taken as a constant.

  9. Investigations on the effect of antioxidant type and concentration and model system matrix on acrylamide formation in model Maillard reaction systems.

    PubMed

    Constantinou, Costas; Koutsidis, Georgios

    2016-04-15

    The formation of acrylamide in model Maillard reaction systems containing phenolic compounds was examined, with regards to phenolic type, concentration, and model system matrix. In dry glyoxal/asparagine waxy maize starch (WMS) systems, 9 out of 10 examined phenolics demonstrated an inhibiting effect, with the most significant reductions (55-60%) observed for caffeoylquinic acids. In WMS glucose/asparagine systems, examination of three different concentrations (0.1, 0.5 and 1 μmol/g WMS) suggested a 'minimum effective concentration' for epicatechin and caffeic acid, whilst addition of caffeoylquinic acids resulted in dose-dependent acrylamide reduction (25-75%). The discordant results of further studies utilising different matrices (dry and wet-to-dry) indicated that, apart from the nature and chemical reactivity, the matrix and the physical state of the reactants might be important for acrylamide formation.

  10. Biomaterials approaches to modeling macrophage-extracellular matrix interactions in the tumor microenvironment.

    PubMed

    Springer, Nora L; Fischbach, Claudia

    2016-08-01

    Tumors are characterized by aberrant extracellular matrix (ECM) remodeling and chronic inflammation. While advances in biomaterials and tissue engineering strategies have led to important new insights regarding the role of ECM composition, structure, and mechanical properties in cancer in general, the functional link between these parameters and macrophage phenotype is poorly understood. Nevertheless, increasing experimental evidence suggests that macrophage behavior is similarly controlled by physicochemical properties of the ECM and consequential changes in mechanosignaling. Here, we will summarize the current knowledge of macrophage biology and ECM-mediated differences in mechanotransduction and discuss future opportunities of biomaterials and tissue engineering platforms to interrogate the functional relationship between these parameters and their relevance to cancer.

  11. Effects of processing on the recovery of food allergens from a model dark chocolate matrix.

    PubMed

    Khuda, Sefat E; Jackson, Lauren S; Fu, Tong-Jen; Williams, Kristina M

    2015-02-01

    To alleviate the risk to allergic consumers, it is crucial to improve factors affecting the detection of food allergens in processed chocolate products. This study evaluated processing effects on (1) recovery of peanut, egg, and milk allergens using five different extraction buffers, and (2) identification of specific allergenic proteins from extracts of incurred chocolate using allergen-specific antibodies and human allergic sera. Immunochemical staining with polyclonal antibodies showed that the addition of detergent or reducing agent improved extraction efficiency of peanut proteins, but not of egg and milk proteins. Tempering decreased antibody binding regardless of extractant. Detection of IgE-reactive peanut, egg, and milk allergens was differentially affected by tempering and extractant. Detection problems associated with matrix and processing effects may be overcome by the choice of extraction buffer and detecting antibody.

  12. Model of brittle matrix composite toughening based on discrete fiber reinforcement

    NASA Technical Reports Server (NTRS)

    Rubinstein, Asher A.

    1992-01-01

    An analytical approach for the analysis of the effectiveness of fiber reinforcement in brittle matrix composites is presented. The analytical method allows consideration of discrete fiber distribution and examination of the development of crack growth parameters on microscale. The problem associated with the bridging zone development is addressed here; therefore, the bridging zone is considered to be smaller than the main preexisting crack, and the small scale approach is used. The mechanics of the reinforcement is accurately accounted for in the process zone of a growing crack. Closed form solutions characterizing the initial failure process are presented for linear and nonlinear force - fiber pullout displacement relationships. The implicit exact solution for the extended bridging zone is presented as well.

  13. Cohomological gauge theory, quiver matrix models and Donaldson-Thomas theory

    NASA Astrophysics Data System (ADS)

    Cirafici, Michele; Sinkovics, Annamaria; Szabo, Richard J.

    2009-03-01

    We study the relation between Donaldson-Thomas theory of Calabi-Yau threefolds and a six-dimensional topological Yang-Mills theory. Our main example is the topological U(N) gauge theory on flat space in its Coulomb branch. To evaluate its partition function we use equivariant localization techniques on its noncommutative deformation. As a result the gauge theory localizes on noncommutative instantons which can be classified in terms of N-coloured three-dimensional Young diagrams. We give to these noncommutative instantons a geometrical description in terms of certain stable framed coherent sheaves on projective space by using a higher-dimensional generalization of the ADHM formalism. From this formalism we construct a topological matrix quantum mechanics which computes an index of BPS states and provides an alternative approach to the six-dimensional gauge theory.

  14. Glucosamine Supplementation Demonstrates a Negative Effect On Intervertebral Disc Matrix in an Animal Model of Disc Degeneration

    PubMed Central

    Jacobs, Lloydine; Vo, Nam; Coehlo, J. Paulo; Dong, Qing; Bechara, Bernard; Woods, Barrett; Hempen, Eric; Hartman, Robert; Preuss, Harry; Balk, Judith; Kang, James; Sowa, Gwendolyn

    2013-01-01

    Study Design Laboratory based controlled in vivo study Objective To determine the in vivo effects of oral glucosamine sulfate on intervertebral disc degeneration Summary of Background Data Although glucosamine has demonstrated beneficial effect in articular cartilage, clinical benefit is uncertain. A CDC report from 2009 reported that many patients are using glucosamine supplementation for low back pain (LBP), without significant evidence to support its use. Because disc degeneration is a major contributor of LBP, we explored the effects of glucosamine on disc matrix homeostasis in an animal model of disc degeneration. Methods Eighteen skeletally mature New Zealand White rabbits were divided into four groups: control, annular puncture, glucosamine, and annular puncture+glucosamine. Glucosamine treated rabbits received daily oral supplementation with 107mg/day (weight based equivalent to human 1500mg/day). Annular puncture surgery involved puncturing the annulus fibrosus (AF) of 3 lumbar discs with a 16G needle to induce degeneration. Serial MRIs were obtained at 0, 4, 8, 12, and 20 weeks. Discs were harvested at 20 weeks for determination of glycosaminoglycan(GAG) content, relative gene expression measured by RT-PCR, and histological analyses. Results The MRI index and NP area of injured discs of glucosamine treated animals with annular puncture was found to be lower than that of degenerated discs from rabbits not supplemented with glucosamine. Consistent with this, decreased glycosaminoglycan was demonstrated in glucosamine fed animals, as determined by both histological and GAG content. Gene expression was consistent with a detrimental effect on matrix. Conclusions These data demonstrate that the net effect on matrix in an animal model in vivo, as measured by gene expression, MRI, histology, and total proteoglycan is anti-anabolic. This raises concern over this commonly used supplement, and future research is needed to establish the clinical relevance of these

  15. Thiol Functionalized Silica-Mixed Matrix Membranes for Silver Capture from Aqueous Solutions: Experimental Results and Modeling

    PubMed Central

    Ladhe, A. R.; Frailie, P.; Hua, D.; Darsillo, M.; Bhattacharyya, D.

    2009-01-01

    The study deals with an aqueous phase application of Mixed Matrix Membranes (MMMs) for silver ion (Ag+) capture. Silica particles were functionalized with 3-mercaptopropyltrimethoxy silane (MPTMS) to introduce free thiol (-SH) groups on the surface. The particles were used as the dispersed phase in the polysulfone or cellulose acetate polymer matrix. The membranes were prepared by the phase inversion method to create more open and interconnected porous structures suitable for liquid phase applications. The effects of the silica properties such as particle size, specific surface area, and porous/nonporous morphology on the silver ion capture capacity were studied. It was demonstrated that the membranes are capable of selectively capturing silver from a solution containing significant concentrations of other metal ions like Ca2+. The membranes were studied to quantify the dynamic capacity for silver ion capture and its dependence on residence time through the adjustment of transmembrane pressure. The thiol-Ag+ interaction was quantified with Quartz Crystal Microbalance in a continuous flow mode experiment and the observations were compared with the membrane results. One dimensional unsteady state model with overall volumetric mass transfer coefficient was developed and solved to predict the silver concentration in the liquid phase and the solid silica phase along the membrane thickness at varying time. The breakthrough data predicted using the model is comparable with the experimental observations. The study demonstrates successful application of the functionalized silica-mixed matrix membranes for selective aqueous phase Ag+ capture with high capacity at low transmembrane pressures. The technique can be easily extended to other applications by altering the functionalized groups on the silica particles. PMID:20098490

  16. A cellular Potts model for the MMP-dependent and -independent cancer cell migration in matrix microtracks of different dimensions

    NASA Astrophysics Data System (ADS)

    Scianna, Marco; Preziosi, Luigi

    2014-03-01

    Cell migration is fundamental in a wide variety of physiological and pathological phenomena, among other in cancer invasion and development. In particular, the migratory/invasive capability of single metastatic cells is fundamental in determining the malignancy of a solid tumor. Specific cell migration phenotypes result for instance from the reciprocal interplay between the biophysical and biochemical properties of both the malignant cells themselves and of the surrounding environment. In particular, the extracellular matrices (ECMs) forming connective tissues can provide both loosely organized zones and densely packed barriers, which may impact cell invasion mode and efficiency. The critical processes involved in cell movement within confined spaces are (i) the proteolytic activity of matrix metalloproteinases (MMPs) and (ii) the deformation of the entire cell body, and in particular of the nucleus. We here present an extended cellular Potts model (CPM) to simulate a bio-engineered matrix system, which tests the active motile behavior of a single cancer cell into narrow channels of different widths. As distinct features of our approach, the cell is modeled as a compartmentalized discrete element, differentiated in the nucleus and in the cytosolic region, while a directional shape-dependent movement is explicitly driven by the evolution of its polarity vector. As outcomes, we find that, in a large track, the tumor cell is not able to maintain a directional movement. On the contrary, a structure of subcellular width behaves as a contact guidance sustaining cell persistent locomotion. In particular, a MMP-deprived cell is able to repolarize and follow the micropattern geometry, while a full MMP activity leads to a secondary track expansion by degrading the matrix structure. Finally, we confirm that cell movement within a subnuclear structure can be achieved either by pericellular proteolysis or by a significant deformation of cell nucleus.

  17. Efficient fully 3D list-mode TOF PET image reconstruction using a factorized system matrix with an image domain resolution model.

    PubMed

    Zhou, Jian; Qi, Jinyi

    2014-02-07

    A factorized system matrix utilizing an image domain resolution model is attractive in fully 3D time-of-flight PET image reconstruction using list-mode data. In this paper, we study a factored model based on sparse matrix factorization that is comprised primarily of a simplified geometrical projection matrix and an image blurring matrix. Beside the commonly-used Siddon's ray-tracer, we propose another more simplified geometrical projector based on the Bresenham's ray-tracer which further reduces the computational cost. We discuss in general how to obtain an image blurring matrix associated with a geometrical projector, and provide theoretical analysis that can be used to inspect the efficiency in model factorization. In simulation studies, we investigate the performance of the proposed sparse factorization model in terms of spatial resolution, noise properties and computational cost. The quantitative results reveal that the factorization model can be as efficient as a non-factored model, while its computational cost can be much lower. In addition we conduct Monte Carlo simulations to identify the conditions under which the image resolution model can become more efficient in terms of image contrast recovery. We verify our observations using the provided theoretical analysis. The result offers a general guide to achieve the optimal reconstruction performance based on a sparse factorization model with an image domain resolution model.

  18. Fundamental comparison of time-domain experimental modal analysis methods based on high- and first-order matrix models

    NASA Astrophysics Data System (ADS)

    Hu, Sau-Lon James; Yang, Wen-Long; Liu, Fu-Shun; Li, Hua-Jun

    2014-12-01

    All time-domain methods for experimental modal analysis (EMA) begin with a mathematical model. Based on either a high-order matrix polynomial model or a first-order state-space model, this paper emphasizes the comparison of numerical conditioning and stability, as well as the modal parameter estimation, among EMA methods. Numerical conditioning pertains to the perturbation behavior of a mathematical problem (model) itself and stability pertains to the perturbation behavior of an algorithm used to solve that problem on a computer. As various EMA methods are modeled differently with distinct solution algorithms, implementing these methods would have different conditioning and stability. In this paper, both deterministic and stochastic EMA methods are covered. Three different scenarios for the response signal are considered: (1) clean response from impulse loading, (2) noisy response from impulse loading, and (3) noisy response from ambient noise excitation. Comparing the numerical conditioning of various EMA methods, this paper theoretically illustrates that methods based on first-order state-space models are more likely to be well-conditioned (with a smaller conditioning number) than those based on high-order polynomial models. Furthermore, the numerical observation of a case study for a 6 degree-of-freedom system also suggests that first-order state-space model methods are more robust and accurate for the estimation of modal frequency and damping.

  19. MATRIX (Multiconfiguration Aerosol TRacker of mIXing state): an aerosol microphysical module for global atmospheric models

    NASA Astrophysics Data System (ADS)

    Bauer, S. E.; Wright, D.; Koch, D.; Lewis, E. R.; McGraw, R.; Chang, L.-S.; Schwartz, S. E.; Ruedy, R.

    2008-05-01

    A new aerosol microphysical module MATRIX, the Multiconfiguation Aerosol TRacker of mIXing state, and its application in the Goddard Institute for Space Studies (GISS) climate model (ModelE) is described. This module, which is based on the quadrature method of moments (QMOM), represents nucleation, condensation, coagulation, internal and external mixing, and cloud-drop activation and provides aerosol particle mass and number concentration and particle size information for up to 16 mixed-mode aerosol populations. Internal and external mixing among aerosol components sulfate, nitrate, ammonium, carbonaceous aerosols, dust and sea-salt particles are represented. The solubility of each aerosol mode, which is explicitly calculated based on its soluble and insoluble components, enables calculation of the dependence of cloud drop activation on the microphysical characterization of multiple soluble modes. A detailed model description and results of box-model simulations of various mode configurations are presented. The number concentration of aerosol particles activated to cloud drops depends on the mode configuration. Simulations on the global scale with the GISS climate model are evaluated against aircraft and station measurements of aerosol mass and number concentration and particle size. The model accurately captures the observed size distributions in the aitken and accumulation modes up to particle diameter 1 μm, in which sulfate, nitrate, black and organic carbon are predominantly located; however the model underestimates coarse-mode number concentration and size, especially in the marine environment.

  20. An agent-based model for elasto-plastic mechanical interactions between cells, basement membrane and extracellular matrix.

    PubMed

    D'Antonio, Gianluca; Macklin, Paul; Preziosi, Luigi

    2013-02-01

    The basement membrane (BM) and extracellular matrix (ECM) play critical roles in developmental and cancer biology, and are of great interest in biomathematics. We introduce a model of mechanical cell-BM-ECM interactions that extends current (visco)elastic models (e.g. [8,16]), and connects to recent agent-based cell models (e.g. [2,3,20,26]). We model the BM as a linked series of Hookean springs, each with time-varying length, thickness, and spring constant. Each BM spring node exchanges adhesive and repulsive forces with the cell agents using potential functions. We model elastic BM-ECM interactions with analogous ECM springs. We introduce a new model of plastic BM and ECM reorganization in response to prolonged strains, and new constitutive relations that incorporate molecular-scale effects of plasticity into the spring constants. We find that varying the balance of BM and ECM elasticity alters the node spacing along cell boundaries, yielding a nonuniform BM thickness. Uneven node spacing generates stresses that are relieved by plasticity over long times. We find that elasto-viscoplastic cell shape response is critical to relieving uneven stresses in the BM. Our modeling advances and results highlight the importance of rigorously modeling of cell-BM-ECM interactions in clinically important conditions with significant membrane deformations and time-varying membrane properties, such as aneurysms and progression from in situ to invasive carcinoma.

  1. Bioengineered 3D brain tumor model to elucidate the effects of matrix stiffness on glioblastoma cell behavior using PEG-based hydrogels.

    PubMed

    Wang, Christine; Tong, Xinming; Yang, Fan

    2014-07-07

    Glioblastoma (GBM) is the most common and aggressive form of primary brain tumor with a median survival of 12-15 months, and the mechanisms underlying GBM tumor progression remain largely elusive. Given the importance of tumor niche signaling in driving GBM progression, there is a strong need to develop in vitro models to facilitate analysis of brain tumor cell-niche interactions in a physiologically relevant and controllable manner. Here we report the development of a bioengineered 3D brain tumor model to help elucidate the effects of matrix stiffness on GBM cell fate using poly(ethylene-glycol) (PEG)-based hydrogels with brain-mimicking biochemical and mechanical properties. We have chosen PEG given its bioinert nature and tunable physical property, and the resulting hydrogels allow tunable matrix stiffness without changing the biochemical contents. To facilitate cell proliferation and migration, CRGDS and a MMP-cleavable peptide were chemically incorporated. Hyaluronic acid (HA) was also incorporated to mimic the concentration in the brain extracellular matrix. Using U87 cells as a model GBM cell line, we demonstrate that such biomimetic hydrogels support U87 cell growth, spreading, and migration in 3D over the course of 3 weeks in culture. Gene expression analyses showed U87 cells actively deposited extracellular matrix and continued to upregulate matrix remodeling genes. To examine the effects of matrix stiffness on GBM cell fate in 3D, we encapsulated U87 cells in soft (1 kPa) or stiff (26 kPa) hydrogels, which respectively mimics the matrix stiffness of normal brain or GBM tumor tissues. Our results suggest that changes in matrix stiffness induce differential GBM cell proliferation, morphology, and migration modes in 3D. Increasing matrix stiffness led to delayed U87 cell proliferation inside hydrogels, but cells formed denser spheroids with extended cell protrusions. Cells cultured in stiff hydrogels also showed upregulation of HA synthase 1 and matrix

  2. Mechanical and structural contribution of non-fibrillar matrix in uniaxial tension: a collagen-agarose co-gel model.

    PubMed

    Lake, Spencer P; Barocas, Victor H

    2011-07-01

    The mechanical role of non-fibrillar matrix and the nature of its interaction with the collagen network in soft tissues remain poorly understood, in part because of the lack of a simple experimental model system to quantify these interactions. This study's objective was to examine mechanical and structural properties of collagen-agarose co-gels, utilized as a simplified model system, to understand better the relationships between the collagen network and non-fibrillar matrix. We hypothesized that the presence of agarose would have a pronounced effect on microstructural reorganization and mechanical behavior. Samples fabricated from gel solutions containing 1.0 mg/mL collagen and 0, 0.125, or 0.25% w/v agarose were evaluated via scanning electron microscopy, incremental tensile stress-relaxation tests, and polarized light imaging. While the incorporation of agarose did not dramatically alter collagen network morphology, agarose led to concentration-dependent changes in mechanical and structural properties. Specifically, resistance of co-gels to volume change corresponded with differences in fiber reorientation and elastic/viscoelastic mechanics. Results demonstrate strong relationships between tissue properties and offer insight into behavior of tissues of varying Poisson's ratio and fiber kinematics. Results also suggest that non-fibrillar material may have significant effects on properties of artificial and native tissues even in tension, which is generally assumed to be collagen dominated.

  3. Matrix-fracture transfer shape factor for modeling flow of a compressible fluid in dual-porosity media

    NASA Astrophysics Data System (ADS)

    Ranjbar, Ehsan; Hassanzadeh, Hassan

    2011-05-01

    The matrix-fracture transfer shape factor is one of the important parameters in the modeling of fluid flow in fractured porous media using a dual-porosity concept. Warren and Root [36] introduced the dual-porosity concept and suggested a relation for the shape factor. There is no general relationship for determining the shape factor for a single-phase flow of slightly compressible fluids. Therefore, different studies reported different values for this parameter, as an input into the flow models. Several investigations have been reported on the shape factor for slightly compressible fluids. However, the case of compressible fluids has not been investigated in the past. The focus of this study is, therefore, to find the shape factor for the single-phase flow of compressible fluids (gases) in fractured porous media. In this study, a model for the determination of the shape factor for compressible fluids is presented; and, the solution of nonlinear gas diffusivity equation is used to derive the shape factor. The integral method and the method of moments are used to solve the nonlinear governing equation by considering the pressure dependency of the viscosity and isothermal compressibility of the fluid. The approximate semi-analytical model for the shape factor presented in this study is verified using single-porosity, fine-grid, numerical simulations. The dependency of the shape factor on the gas specific gravity, pressure and temperature are also investigated. The theoretical analysis presented improves our understanding of fluid flow in fractured porous media. In addition, the developed matrix-fracture transfer shape factor can be used as an input for modeling flow of compressible fluids in dual-porosity systems, such as naturally fractured gas reservoirs, coalbed methane reservoirs and fractured tight gas reservoirs.

  4. Reproducing Electric Field Observations during Magnetic Storms by means of Rigorous 3-D Modelling and Distortion Matrix Co-estimation

    NASA Astrophysics Data System (ADS)

    Püthe, Christoph; Manoj, Chandrasekharan; Kuvshinov, Alexey

    2015-04-01

    Electric fields induced in the conducting Earth during magnetic storms drive currents in power transmission grids, telecommunication lines or buried pipelines. These geomagnetically induced currents (GIC) can cause severe service disruptions. The prediction of GIC is thus of great importance for public and industry. A key step in the prediction of the hazard to technological systems during magnetic storms is the calculation of the geoelectric field. To address this issue for mid-latitude regions, we developed a method that involves 3-D modelling of induction processes in a heterogeneous Earth and the construction of a model of the magnetospheric source. The latter is described by low-degree spherical harmonics; its temporal evolution is derived from observatory magnetic data. Time series of the electric field can be computed for every location on Earth's surface. The actual electric field however is known to be perturbed by galvanic effects, arising from very local near-surface heterogeneities or topography, which cannot be included in the conductivity model. Galvanic effects are commonly accounted for with a real-valued time-independent distortion matrix, which linearly relates measured and computed electric fields. Using data of various magnetic storms that occurred between 2000 and 2003, we estimated distortion matrices for observatory sites onshore and on the ocean bottom. Strong correlations between modellings and measurements validate our method. The distortion matrix estimates prove to be reliable, as they are accurately reproduced for different magnetic storms. We further show that 3-D modelling is crucial for a correct separation of galvanic and inductive effects and a precise prediction of electric field time series during magnetic storms. Since the required computational resources are negligible, our approach is suitable for a real-time prediction of GIC. For this purpose, a reliable forecast of the source field, e.g. based on data from satellites

  5. Two-flux transfer matrix model for predicting the reflectance and transmittance of duplex halftone prints.

    PubMed

    Mazauric, Serge; Hébert, Mathieu; Simonot, Lionel; Fournel, Thierry

    2014-12-01

    We introduce a model allowing convenient calculation of the spectral reflectance and transmittance of duplex prints. It is based on flux transfer matrices and enables retrieving classical Kubelka-Munk formulas, as well as extended formulas for nonsymmetric layers. By making different assumptions on the flux transfers, we obtain two predictive models for the duplex halftone prints: the "duplex Clapper-Yule model," which is an extension of the classical Clapper-Yule model, and the "duplex primary reflectance-transmittance model." The two models can be calibrated from either reflectance or transmittance measurements; only the second model can be calibrated from both measurements, thus giving optimal accuracy for both reflectance and transmittance predictions. The conceptual differences between the two models are deeply analyzed, as well as their advantages and drawbacks in terms of calibration. According to the test carried out in this study with paper printed in inkjet, their predictive performances are good provided appropriate calibration options are selected.

  6. Grassmann matrix quantum mechanics

    DOE PAGES

    Anninos, Dionysios; Denef, Frederik; Monten, Ruben

    2016-04-21

    We explore quantum mechanical theories whose fundamental degrees of freedom are rectangular matrices with Grassmann valued matrix elements. We study particular models where the low energy sector can be described in terms of a bosonic Hermitian matrix quantum mechanics. We describe the classical curved phase space that emerges in the low energy sector. The phase space lives on a compact Kähler manifold parameterized by a complex matrix, of the type discovered some time ago by Berezin. The emergence of a semiclassical bosonic matrix quantum mechanics at low energies requires that the original Grassmann matrices be in the long rectangular limit.more » In conclusion, we discuss possible holographic interpretations of such matrix models which, by construction, are endowed with a finite dimensional Hilbert space.« less

  7. Grassmann matrix quantum mechanics

    SciTech Connect

    Anninos, Dionysios; Denef, Frederik; Monten, Ruben

    2016-04-21

    We explore quantum mechanical theories whose fundamental degrees of freedom are rectangular matrices with Grassmann valued matrix elements. We study particular models where the low energy sector can be described in terms of a bosonic Hermitian matrix quantum mechanics. We describe the classical curved phase space that emerges in the low energy sector. The phase space lives on a compact Kähler manifold parameterized by a complex matrix, of the type discovered some time ago by Berezin. The emergence of a semiclassical bosonic matrix quantum mechanics at low energies requires that the original Grassmann matrices be in the long rectangular limit. In conclusion, we discuss possible holographic interpretations of such matrix models which, by construction, are endowed with a finite dimensional Hilbert space.

  8. Degradation of extracellular matrix by larvae of Schistosoma mansoni. I. Degradation by cercariae as a model for initial parasite invasion of host

    SciTech Connect

    McKerrow, J.H.; Keene, W.E.; Jeong, K.H.; Werb, Z.

    1983-01-01

    The ability of cercariae of Schistosoma mansoni to degrade a model extracellular connective tissue matrix produced by rat vascular smooth muscle cells in culture was investigated. In this model, connective tissue macromolecules are present in the interactive framework that characterizes their structure in vivo. Cercariae were stimulated to degrade the matrix by skin lipid or linoleic acid. At the maximally stimulating concentration of linoleic acid (25 ..mu..g/cm/sup 2/), 68% of the total matrix was degraded, including 57% of the glycoprotein, 79% of the elastin, and 8% of the collagen. Degradation of matrix was inhibited by ..cap alpha../sub 1/-proteinase inhibitor and soybean trypsin inhibitor. Ethylenediaminetetraacetic acid inhibited degradation by unstimulated but not linoleic acid-stimulated cercariae. Preacetabular gland secretions collected from cercariae also degraded the matrix with an activity 86% of that of live cercariae. Preacetabular gland proteolytic activity was also inhibited by ..cap alpha../sub 1/-proteinase inhibitor, soybean trypsin inhibitor, and ethylenediaminetetraacetic acid. The similar characteristics of matrix degradation by both live cercariae and cercarial preacetabular gland secretions support the idea that a proteinase secreted from cercarial preacetabular glands facilitates invasion of skin and connective tissue by these larvae. Degradation of elastin and glycoprotein constituentes of extracellular matrix is probably essential for skin penetration.

  9. ATOMISTIC MODELING OF OIL SHALE KEROGENS AND ASPHALTENES ALONG WITH THEIR INTERACTIONS WITH THE INORGANIC MINERAL MATRIX

    SciTech Connect

    Facelli, Julio; Pugmire, Ronald; Pimienta, Ian

    2011-03-31

    The goal of this project is to obtain and validate three dimensional atomistic models for the organic matter in both oil shales and oil sands. In the case of oil shales the modeling was completed for kerogen, the insoluble portion of the organic matter; for oil sands it was for asphaltenes, a class of molecules found in crude oil. The three dimensional models discussed in this report were developed starting from existing literature two dimensional models. The models developed included one kerogen, based on experimental data on a kerogen isolated from a Green River oil shale, and a set of six representative asphaltenes. Subsequently, the interactions between these organic models and an inorganic matrix was explored in order to gain insight into the chemical nature of this interaction, which could provide vital information in developing efficient methods to remove the organic material from inorganic mineral substrate. The inorganic substrate used to model the interaction was illite, an aluminum silicate oxide clay. In order to obtain the feedback necessary to validate the models, it is necessary to be able to calculate different observable quantities and to show that these observables both reproduce the results of experimental measurements on actual samples as well as that the observables are sensitive to structural differences between models. The observables that were calculated using the models include 13C NMR spectra, the IR vibrational spectra, and the atomic pair wise distribution function; these were chosen as they are among the methods for which both experimental and calculated values can be readily obtained. Where available, comparison was made to experiment results. Finally, molecular dynamic simulations of pyrolysis were completed on the models to gain an understanding into the nature of the decomposition of these materials when heated.

  10. Role of Matrix Metalloproteinases 2 and 9 in Lacrimal Gland Disease in Animal Models of Sjögren's Syndrome

    PubMed Central

    Aluri, Hema S.; Kublin, Claire L.; Thotakura, Suharika; Armaos, Helene; Samizadeh, Mahta; Hawley, Dillon; Thomas, William M.; Leavis, Paul; Makarenkova, Helen P.; Zoukhri, Driss

    2015-01-01

    Purpose Chronic inflammation of the lacrimal gland results in changes in the composition of the extracellular matrix (ECM), which is believed to compromise tissue repair. We hypothesized that increased production/activity of matrix metalloproteinases (MMPs), especially MMP-2 and -9, in inflamed lacrimal glands modifies the ECM environment, therefore disrupting tissue repair. Methods The lacrimal glands from female MRL/lpr and male NOD mice along with their respective control strains were harvested and divided into three pieces and processed for histology, immunohistochemistry, zymography, Western blotting, and RNA analyses. In another study, MRL/lpr mice were treated for 5 weeks with a selective MMP2/9 inhibitor peptide or a control peptide. At the end of treatment, the lacrimal glands were excised and the tissue was processed as described above. Results There was a 2.5- and 2.7-fold increase in MMP2 gene expression levels in MRL/lpr and NOD mice, respectively. Matrix metalloproteinase 2 and 9 enzymatic activities and protein expression levels were significantly upregulated in the lacrimal glands of MRL/lpr and NOD mice compared to controls. Treatment with the MMP2/9 inhibitor resulted in decreased activity of MMP-2 and -9 both in vitro and in vivo. Importantly, MMP2/9 inhibitor treatment of MRL/lpr mice improved aqueous tear production and resulted in reduced number and size of lymphocytic foci in diseased lacrimal glands. Conclusions We conclude that MMP2/9 expression and activity are elevated in lacrimal glands of two murine models of Sjögren's syndrome, suggesting that manipulation of MMP2/9 activity might be a potential therapeutic target in chronically inflamed lacrimal glands. PMID:26244298

  11. Central nervous system extracellular matrix changes in a transgenic mouse model of bovine spongiform encephalopathy.

    PubMed

    Costa, Carme; Tortosa, Raül; Vidal, Enric; Padilla, Danielle; Torres, Juan Maria; Ferrer, Isidre; Pumarola, Martí; Bassols, Anna

    2009-11-01

    Bovine spongiform encephalopathy (BSE) is a transmissible spongiform encephalopathy characterised by accumulation of resistant prion protein (PrP(BSE)), neuronal loss, spongiosus and glial cell proliferation. In this study, properties of the extracellular matrix (ECM) were investigated in boTg110 transgenic mice over-expressing the bovine cellular prion protein (PrP(c)) and infected with BSE. Using immunohistochemistry with Wisteria floribunda agglutinin as a specific marker for perineuronal nets (PNNs) and antibodies against aggrecan and hyaluronic acid binding protein, loss of ECM was correlated with PrP(BSE) accumulation and activation of astrocytes and microglia. PrP(BSE) accumulation and glial cell activation were detected from the earliest stages of the disease and increased in the terminal stages. Decreases in PNNs, aggrecan and hyaluronic acid were observed only in the terminal stages and correlated with the distribution of PrP(BSE) and activated glial cells. This study suggests that the loss of PNNs, aggrecan and hyaluronic acid is a consequence of PrP(BSE) accumulation. Degradation of ECM in BSE may be due to secretion of degradative enzymes by activated glial cells.

  12. Effect of Extracellular Matrix Membrane on Bone Formation in a Rabbit Tibial Defect Model

    PubMed Central

    Kim, Sungtae; Kim, Se Won; Lee, Jong Ho

    2016-01-01

    Absorbable extracellular matrix (ECM) membrane has recently been used as a barrier membrane (BM) in guided tissue regeneration (GTR) and guided bone regeneration (GBR). Absorbable BMs are mostly based on collagen, which is more biocompatible than synthetic materials. However, implanted absorbable BMs can be rapidly degraded by enzymes in vivo. In a previous study, to delay degradation time, collagen fibers were treated with cross-linking agents. These compounds prevented the enzymatic degradation of BMs. However, cross-linked BMs can exhibit delayed tissue integration. In addition, the remaining cross-linker could induce inflammation. Here, we attempted to overcome these problems using a natural ECM membrane. The membrane consisted of freshly harvested porcine pericardium that was stripped from cells and immunoreagents by a cleaning process. Acellular porcine pericardium (APP) showed a bilayer structure with a smooth upper surface and a significantly coarser bottom layer. APP is an ECM with a thin layer (0.18–0.35 mm) but with excellent mechanical properties. Tensile strength of APP was 14.15 ± 2.24 MPa. In in vivo experiments, APP was transplanted into rabbit tibia. The biocompatible material was retained for up to 3 months without the need for cross-linking. Therefore, we conclude that APP could support osteogenesis as a BM for up to 3 months. PMID:27047963

  13. Molecular surface area based predictive models for the adsorption and diffusion of disperse dyes in polylactic acid matrix.

    PubMed

    Xu, Suxin; Chen, Jiangang; Wang, Bijia; Yang, Yiqi

    2015-11-15

    Two predictive models were presented for the adsorption affinities and diffusion coefficients of disperse dyes in polylactic acid matrix. Quantitative structure-sorption behavior relationship would not only provide insights into sorption process, but also enable rational engineering for desired properties. The thermodynamic and kinetic parameters for three disperse dyes were measured. The predictive model for adsorption affinity was based on two linear relationships derived by interpreting the experimental measurements with molecular structural parameters and compensation effect: ΔH° vs. dye size and ΔS° vs. ΔH°. Similarly, the predictive model for diffusion coefficient was based on two derived linear relationships: activation energy of diffusion vs. dye size and logarithm of pre-exponential factor vs. activation energy of diffusion. The only required parameters for both models are temperature and solvent accessible surface area of the dye molecule. These two predictive models were validated by testing the adsorption and diffusion properties of new disperse dyes. The models offer fairly good predictive ability. The linkage between structural parameter of disperse dyes and sorption behaviors might be generalized and extended to other similar polymer-penetrant systems.

  14. Optical modeling of thin film silicon solar cells by combination of the transfer-matrix method and the Raytracer algorithm

    NASA Astrophysics Data System (ADS)

    Walder, Cordula; Lacombe, Jürgen; von Maydell, Karsten; Agert, Carsten

    2012-06-01

    This article deals with an optical model which describes silicon thin film solar cells with rough interfaces in a fast and easy way. In order to simulate thin layer stacks with rough interfaces diffuse scattering as well as interference effects have to be taken into account. Algorithms like the Finite-Difference Time-Domain method (FDTD) solve the Maxwell Equations and therefore fulfil these demands. Yet they take up a considerable amount of simulation time and computation capacity. To overcome these drawbacks an optical model was developed which combines the Transfer- Matrix-Method (TMM) and the Raytracer algorithm. The fraction of TMM and Raytracer in the model is determined by a separating function which can be interpreted as the integral haze. In order to verify the combined optical model a series of amorphous silicon single cells with varying intrinsic layer thicknesses was produced on two different kinds of textured substrates. The results of the combined optical model are compared to measured data as well as to the simulation results of the FDTD method. It can be shown that the combined optical model yields good results at low simulation time.

  15. Development of a three-dimensional unit cell to model the micromechanical response of a collagen-based extracellular matrix.

    PubMed

    Susilo, Monica E; Roeder, Blayne A; Voytik-Harbin, Sherry L; Kokini, Klod; Nauman, Eric A

    2010-04-01

    The three-dimensional microstructure and mechanical properties of the collagen fibrils within the extracellular matrix (ECM) is now being recognized as a primary factor in regulating cell proliferation and differentiation. Therefore, an appreciation of the mechanical aspects by which a cell interacts with its ECM is required for the development of engineered tissues. Ultimately, using these interactions to design tissue equivalents requires mathematical models with three-dimensional architecture. In this study, a three-dimensional model of a collagen fibril matrix undergoing uniaxial tensile stress was developed by making use of cellular solids. A structure consisting of thin struts was chosen to represent the arrangement of collagen fibrils within an engineered ECM. To account for the large deformation of tissues, the collagen fibrils were modeled as hyperelastic neo-Hookean or Mooney-Rivlin materials. The use of cellular solids allowed the fibril properties to be related to the ECM properties in closed form, which, in turn, allowed the estimation of fibril properties using ECM experimental data. A set of previously obtained experimental data consisting of simultaneous measures of the fibril microstructure and mechanical tests was used to evaluate the model's capability to estimate collagen fibril mechanical property when given tissue-scale data and to predict the tissue-scale mechanical properties when given estimated fibril stiffness. The fibril tangent modulus was found to be 1.26 + or - 0.70 and 1.62 + or - 0.88 MPa when the fibril was modeled as neo-Hookean and Mooney-Rivlin material, respectively. There was no statistical significance of the estimated fibril tangent modulus among the different groups. Sensitivity analysis showed that the fibril mechanical properties and volume fraction were the two input parameters which required accurate values. While the volume fraction was easily obtained from the initial image of the gel, the fibril mechanical properties

  16. Noninvasive glucometer model using partial least square regression technique for human blood matrix

    NASA Astrophysics Data System (ADS)

    Parab, J. S.; Gad, R. S.; Naik, G. M.

    2010-05-01

    In this article, we have highlighted the partial least square regression (PLSR) model to predict the glucose level in human blood by considering only five variants. The PLSR model is experimentally validated for the 13 templates samples. The root mean square error analysis of design model and experimental sample is found to be satisfactory with the values of 3.459 and 5.543, respectively. In PLSR templates design is a critical issue for the number of variants participating in the model. Ensemble consisting of five major variants is simulated to replicate the signatures of these constituents in the human blood, i.e., alanine, urea, lactate, glucose, and ascorbate. Multivariate system using PLSR plays important role in understanding chemometrics of such ensemble. The resultant spectra of all these constituents are generated to create templates for the PLSR model. This model has potential scope in designing a near-infrared spectroscopy based noninvasive glucometer.

  17. Matrix Population Model for Estimating Effects from Time-Varying Aquatic Exposures: Technical Documentation

    EPA Science Inventory

    The Office of Pesticide Programs models daily aquatic pesticide exposure values for 30 years in its risk assessments. However, only a fraction of that information is typically used in these assessments. The population model employed herein is a deterministic, density-dependent pe...

  18. The effect of manipulation of silk scaffold fabrication parameters on matrix performance in a murine model of bladder augmentation

    PubMed Central

    Gomez, Pablo; Gil, Eun Seok; Lovett, Michael L.; Rockwood, Danielle N.; Di Vizio, Dolores; Kaplan, David L.; Adam, Rosalyn M.; Estrada, Carlos R.; Mauney, Joshua R.

    2011-01-01

    Autologous gastrointestinal segments are utilized as the primary option for bladder reconstructive procedures despite their inherent morbidity and significant complication rate. Multi-laminate biomaterials derived from Bombyx mori silk fibroin and prepared from a gel spinning process may serve as a superior alternative for bladder tissue engineering due to their robust mechanical properties, biocompatibility, and processing plasticity. In the present study, we sought to determine the impact of variations in winding (axial slew rate: 2 and 40 mm/sec) and post-winding (methanol and lyophilization) fabrication parameters on the in vivo performance of gel spun silk scaffolds in a murine model of bladder augmentation. Three silk matrix groups with distinct structural and mechanical properties were investigated following 10 weeks of implantation including our original prototype previously shown to support bladder regeneration, Group 1 (2mm/sec, methanol) as well as Group 2 (40mm/sec, methanol) and Group 3 (40mm/sec, lyophilization) configurations. Non surgical animals were assessed in parallel as controls. Quantification of residual scaffold area demonstrated that while Group 1 and 2 scaffolds were largely intact, processing parameters utilized for Group 3 led to significantly higher degrees of scaffold degradation in comparison to Group 1. Histological (hematoxylin and eosin, masson’s trichrome) and immunohistochemical (IHC) analyses showed comparable extents of smooth muscle regeneration and contractile protein (α-smooth muscle actin and SM22α) expression within the original defect site throughout all matrix groups similar to controls. Parallel evaluations demonstrated transitional urothelial formation with prominent uroplakin and p63 protein expression supported by Group 1 and 3 scaffolds, while Group 2 variants supported a thin, immature epithelium composed primarily of uroplakin-negative, p63-positive basal cells. Voided stain on paper analysis revealed similar

  19. Repeated short climatic change affects the epidermal differentiation program and leads to matrix remodeling in a human organotypic skin model.

    PubMed

    Boutrand, Laetitia-Barbollat; Thépot, Amélie; Muther, Charlotte; Boher, Aurélie; Robic, Julie; Guéré, Christelle; Vié, Katell; Damour, Odile; Lamartine, Jérôme

    2017-01-01

    Human skin is subject to frequent changes in ambient temperature and humidity and needs to cope with these environmental modifications. To decipher the molecular response of human skin to repeated climatic change, a versatile model of skin equivalent subject to "hot-wet" (40°C, 80% relative humidity [RH]) or "cold-dry" (10°C, 40% RH) climatic stress repeated daily was used. To obtain an exhaustive view of the molecular mechanisms elicited by climatic change, large-scale gene expression DNA microarray analysis was performed and modulated function was determined by bioinformatic annotation. This analysis revealed several functions, including epidermal differentiation and extracellular matrix, impacted by repeated variations in climatic conditions. Some of these molecular changes were confirmed by histological examination and protein expression. Both treatments (hot-wet and cold-dry) reduced the expression of genes encoding collagens, laminin, and proteoglycans, suggesting a profound remodeling of the extracellular matrix. Strong induction of the entire family of late cornified envelope genes after cold-dry exposure, confirmed at protein level, was also observed. These changes correlated with an increase in epidermal differentiation markers such as corneodesmosin and a thickening of the stratum corneum, indicating possible implementation of defense mechanisms against dehydration. This study for the first time reveals the complex pattern of molecular response allowing adaption of human skin to repeated change in its climatic environment.

  20. Repeated short climatic change affects the epidermal differentiation program and leads to matrix remodeling in a human organotypic skin model

    PubMed Central

    Boutrand, Laetitia-Barbollat; Thépot, Amélie; Muther, Charlotte; Boher, Aurélie; Robic, Julie; Guéré, Christelle; Vié, Katell; Damour, Odile; Lamartine, Jérôme

    2017-01-01

    Human skin is subject to frequent changes in ambient temperature and humidity and needs to cope with these environmental modifications. To decipher the molecular response of human skin to repeated climatic change, a versatile model of skin equivalent subject to “hot–wet” (40°C, 80% relative humidity [RH]) or “cold–dry” (10°C, 40% RH) climatic stress repeated daily was used. To obtain an exhaustive view of the molecular mechanisms elicited by climatic change, large-scale gene expression DNA microarray analysis was performed and modulated function was determined by bioinformatic annotation. This analysis revealed several functions, including epidermal differentiation and extracellular matrix, impacted by repeated variations in climatic conditions. Some of these molecular changes were confirmed by histological examination and protein expression. Both treatments (hot–wet and cold–dry) reduced the expression of genes encoding collagens, laminin, and proteoglycans, suggesting a profound remodeling of the extracellular matrix. Strong induction of the entire family of late cornified envelope genes after cold–dry exposure, confirmed at protein level, was also observed. These changes correlated with an increase in epidermal differentiation markers such as corneodesmosin and a thickening of the stratum corneum, indicating possible implementation of defense mechanisms against dehydration. This study for the first time reveals the complex pattern of molecular response allowing adaption of human skin to repeated change in its climatic environment. PMID:28243135