The minimal carcinoma triple stain is superior to commercially available multiplex immunohistochemical stains: breast triple stain and LC/DC breast cocktail.

PubMed

Ginter, Paula S; Varma, Sonal; Liu, Yi-Fang; Shin, Sandra J

2015-12-01

The Minimal Carcinoma (MC) Triple Stain is a tri-chromogen multiplex immunostain (CK7, p63, and E-cadherin) helpful in classifying morphologically ambiguous and/or small carcinomas as either ductal or lobular and/or in situ or invasive. We compared the utility of this stain with two commercially available duplex/multiplex immunostains: Breast Triple Stain (BTS) (Clarient, Aliso Viejo, CA; CK5, p63, and CK8/18) and LC/DC Breast Cocktail (LCDC) (Biocare, Concord, CA; E-cadherin and p120). Ninety-seven mammary carcinomas stained with the MC Triple Stain, BTS, and LCDC were compared. The MC Triple Stain, LCDC, and BTS were diagnostic in 90 (93%) of 97, 82 (85%) of 97, and 85 (88%) of 97 of cases, respectively. All stains showed decreased diagnostic utility due to variability in tissue integrity, quality of the staining, and/or ease of interpretation. In cases where all immunostains were interpretable, the MC Triple Stain yielded the most information. When technically sufficient, all three immunostains demonstrated relative strengths and weaknesses in their ability to provide diagnostic information with the highest consistency and ease of use. Many cases stained with LCDC were technically insufficient due to a suboptimal staining protocol provided by the company. Overall, the MC Triple Stain outperformed BTS and LCDC by more consistently providing more diagnostic information. The MC Triple Stain is a viable alternative to other multiplex immunostains in evaluating small foci of carcinoma, particularly when both the histologic type and extent of disease (in situ vs invasive) require clarification. Copyright© by the American Society for Clinical Pathology.

Status of Activities to Implement a Sustainable System of MC&A Equipment and Methodological Support at Rosatom Facilities

DOE Office of Scientific and Technical Information (OSTI.GOV)

J.D. Sanders

Under the U.S.-Russian Material Protection, Control and Accounting (MPC&A) Program, the Material Control and Accounting Measurements (MCAM) Project has supported a joint U.S.-Russian effort to coordinate improvements of the Russian MC&A measurement system. These efforts have resulted in the development of a MC&A Equipment and Methodological Support (MEMS) Strategic Plan (SP), developed by the Russian MEM Working Group. The MEMS SP covers implementation of MC&A measurement equipment, as well as the development, attestation and implementation of measurement methodologies and reference materials at the facility and industry levels. This paper provides an overview of the activities conducted under the MEMS SP,more » as well as a status on current efforts to develop reference materials, implement destructive and nondestructive assay measurement methodologies, and implement sample exchange, scrap and holdup measurement programs across Russian nuclear facilities.« less

50 CFR 81.8 - Payments.

Code of Federal Regulations, 2013 CFR

2013-10-01

... ASSISTANCE-WILDLIFE AND SPORT FISH RESTORATION PROGRAM CONSERVATION OF ENDANGERED AND THREATENED SPECIES OF... Management and Budget Circular A-102. (c) Payments under the Endangered Species Act, including such...

50 CFR 81.8 - Payments.

Code of Federal Regulations, 2014 CFR

2014-10-01

... ASSISTANCE-WILDLIFE AND SPORT FISH RESTORATION PROGRAM CONSERVATION OF ENDANGERED AND THREATENED SPECIES OF... Management and Budget Circular A-102. (c) Payments under the Endangered Species Act, including such...

50 CFR 81.8 - Payments.

Code of Federal Regulations, 2011 CFR

2011-10-01

... ASSISTANCE-WILDLIFE SPORT FISH RESTORATION PROGRAM CONSERVATION OF ENDANGERED AND THREATENED SPECIES OF FISH... real property, subject to standards established by the Secretary as provided in Office of Management...

50 CFR 81.8 - Payments.

Code of Federal Regulations, 2012 CFR

2012-10-01

... ASSISTANCE-WILDLIFE SPORT FISH RESTORATION PROGRAM CONSERVATION OF ENDANGERED AND THREATENED SPECIES OF FISH... real property, subject to standards established by the Secretary as provided in Office of Management...

Toward high-efficiency and detailed Monte Carlo simulation study of the granular flow spallation target

NASA Astrophysics Data System (ADS)

Cai, Han-Jie; Zhang, Zhi-Lei; Fu, Fen; Li, Jian-Yang; Zhang, Xun-Chao; Zhang, Ya-Ling; Yan, Xue-Song; Lin, Ping; Xv, Jian-Ya; Yang, Lei

2018-02-01

The dense granular flow spallation target is a new target concept chosen for the Accelerator-Driven Subcritical (ADS) project in China. For the R&D of this kind of target concept, a dedicated Monte Carlo (MC) program named GMT was developed to perform the simulation study of the beam-target interaction. Owing to the complexities of the target geometry, the computational cost of the MC simulation of particle tracks is highly expensive. Thus, improvement of computational efficiency will be essential for the detailed MC simulation studies of the dense granular target. Here we present the special design of the GMT program and its high efficiency performance. In addition, the speedup potential of the GPU-accelerated spallation models is discussed.

50 CFR 81.8 - Payments.

Code of Federal Regulations, 2010 CFR

2010-10-01

... ASSISTANCE-WILDLIFE SPORT FISH RESTORATION PROGRAM CONSERVATION OF ENDANGERED AND THREATENED SPECIES OF FISH... States having a common interest in one or more endangered or threatened species, the conservation of...

US-Russian Cooperation in Upgrading MC&A System at Rosatom Facilities: Measurement of Nuclear Materials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Powell, Danny H; Jensen, Bruce A

2011-01-01

Improve protection of weapons-usable nuclear material from theft or diversion through the development and support of a nationwide sustainable and effective Material Control and Accountability (MC&A) program based on material measurement. The material protection, control, and accountability (MPC&A) cooperation has yielded significant results in implementing MC&A measurements at Russian nuclear facilities: (1) Establishment of MEM WG and MEMS SP; (2) Infrastructure for development, certification, and distribution of RMs; and (3) Coordination on development and implementation of MMs.

7 CFR 1599.4 - Application process.

Code of Federal Regulations, 2012 CFR

2012-01-01

... associations, community infrastructure, and health, nutrition, water and sanitation conditions; (3) Information... improvements in the learning environment; (iii) Improved maternal, child and student health and nutrition; (iv... OF AGRICULTURE McGOVERN-DOLE INTERNATIONAL FOOD FOR EDUCATION AND CHILD NUTRITION PROGRAM § 1599.4...

7 CFR 1599.4 - Application process.

Code of Federal Regulations, 2014 CFR

2014-01-01

... associations, community infrastructure, and health, nutrition, water and sanitation conditions; (3) Information... improvements in the learning environment; (iii) Improved maternal, child and student health and nutrition; (iv... OF AGRICULTURE McGOVERN-DOLE INTERNATIONAL FOOD FOR EDUCATION AND CHILD NUTRITION PROGRAM § 1599.4...

7 CFR 1599.4 - Application process.

Code of Federal Regulations, 2011 CFR

2011-01-01

... associations, community infrastructure, and health, nutrition, water and sanitation conditions; (3) Information... improvements in the learning environment; (iii) Improved maternal, child and student health and nutrition; (iv... OF AGRICULTURE McGOVERN-DOLE INTERNATIONAL FOOD FOR EDUCATION AND CHILD NUTRITION PROGRAM § 1599.4...

7 CFR 1599.4 - Application process.

Code of Federal Regulations, 2013 CFR

2013-01-01

... associations, community infrastructure, and health, nutrition, water and sanitation conditions; (3) Information... improvements in the learning environment; (iii) Improved maternal, child and student health and nutrition; (iv... OF AGRICULTURE McGOVERN-DOLE INTERNATIONAL FOOD FOR EDUCATION AND CHILD NUTRITION PROGRAM § 1599.4...

The evaluation of different forest structural indices to predict the stand aboveground biomass of even-aged Scotch pine (Pinus sylvestris L.) forests in Kunduz, Northern Turkey.

PubMed

Ercanli, İlker; Kahriman, Aydın

2015-03-01

We assessed the effect of stand structural diversity, including the Shannon, improved Shannon, Simpson, McIntosh, Margelef, and Berger-Parker indices, on stand aboveground biomass (AGB) and developed statistical prediction models for the stand AGB values, including stand structural diversity indices and some stand attributes. The AGB prediction model, including only stand attributes, accounted for 85 % of the total variance in AGB (R (2)) with an Akaike's information criterion (AIC) of 807.2407, Bayesian information criterion (BIC) of 809.5397, Schwarz Bayesian criterion (SBC) of 818.0426, and root mean square error (RMSE) of 38.529 Mg. After inclusion of the stand structural diversity into the model structure, considerable improvement was observed in statistical accuracy, including 97.5 % of the total variance in AGB, with an AIC of 614.1819, BIC of 617.1242, SBC of 633.0853, and RMSE of 15.8153 Mg. The predictive fitting results indicate that some indices describing the stand structural diversity can be employed as significant independent variables to predict the AGB production of the Scotch pine stand. Further, including the stand diversity indices in the AGB prediction model with the stand attributes provided important predictive contributions in estimating the total variance in AGB.

Health behaviours of pregnant women in Fort McMurray, Alberta.

PubMed

Dow-Clarke, R A; MacCalder, L; Hessel, P A

1994-01-01

Baby. Vision was a survey of lifestyle behaviours of pregnant women in the Fort McMurray area, conducted between April and June 1989. The survey goal was to establish baseline data for coordinated health promotion programs for expectant parents. Questionnaires were completed by 173 pregnant women. Overall the women were well educated and in high-income households. Approximately one third of the women (36.6%) reported smoking during pregnancy. Most (90%) were exposed to second-hand smoke. Almost half (48.8%) stated they had consumed alcoholic beverages since learning of their pregnancy. Thirty percent were unaware of their immunization status. Most (98%) reported doing something to improve their health during this pregnancy, improved eating habits being most often mentioned. The results indicate that health promotion activities might improve the birth outcomes in Fort McMurray and outlying areas. The data may be relevant to other relatively remote areas in Canada.

Circularly polarized measurements of radar backscatter from terrain

NASA Astrophysics Data System (ADS)

Wilson, E. A.; Brunfeldt, D. R.; Ulaby, F. T.; Holtzman, J. C.

1980-02-01

This report documents the design changes to the University of Kansas MAS 8-18/35 scatterometer system required to incorporate a circular polarization capability and a subsequent backscatter measurement program. The modifications enable the MAS 8-18/35 system to acquire both linear (HH, HV, VV) and circular (RR, RL, LL) radar backscatter data over its entire operating range of 8-18 GHz and 35 GHz. The measurement program described herein consisted of measurements of the backscatter coefficient, as a function of the angle of incidence (0-80) at selected frequencies in the 8-18 GHz range using circular polarization. Targets studied included coniferous and deciduous trees, wet and dry asphalt and concrete and bare and plowed ground at various moisture conditions. Coniferous and deciduous tree measurements were taken in both August and November so that seasonal changes could be observed.

A Systemwide Approach to Improving Early Childhood Program Quality in the Detroit Metropolitan Area. Final Report.

ERIC Educational Resources Information Center

Shouse, A. Clay; Epstein, Ann S.

This document is the final report of the McGregor-funded High/Scope training initiative, a system-wide approach to improving the quality of early childhood programs in the Detroit metropolitan area. The 3-year project was based on the validated High/Scope educational approach and training model, which advocates hands-on active learning for both…

The ERAU Undergraduate Meteorology Program, Students' Learning, and Measures of Success

NASA Astrophysics Data System (ADS)

Ivanova, D.

2008-12-01

The goal of this paper is to introduce the relationship, teaching techniques, research experience, and critical thinking interactions between Embry-Riddle Aeronautical University(ERAU) McNair mentors and their meteorology students to ensure the students' continued academic success and path to graduate school. The primary goal of the McNair Scholars Program is to provide experiences that prepare selected undergraduate students for doctoral study. The overriding goal of the McNair programs is to increase the number of underrepresented students who will obtain doctoral degrees and go on to teach and do research in institutions of higher learning. The underrepresented students are often those with limited resources, however encouraging critical thinking and undergraduate research experience is an effective tool for engaging them in applied meteorology. How do we help underrepresented meteorology students become aware of their strong and weak sides, help their learning, improve their learning strategies, and guide them toward a successful graduate school path? What skills are particularly important in developing a solid undergraduate expertise in meteorology? How can these skills be taught effectively? What are the obstacles the McNair scholars have to overcome? Some students are under prepared in math or have math phobias, others are learning English as they are learning the complex vocabulary of meteorology, or arrive in the classroom with communication skills that are not fully developed. We discuss our experiences as part of the ERAU McNair Scholars Program and Department of meteorology faculty body.

An 8-week multimodal treatment program improves symptoms of knee osteoarthritis: a real-world multicenter experience

PubMed Central

Miller, Larry E; Block, Jon E

2013-01-01

Purpose To report outcomes from a 5-year real-world clinical experience with a multimodal treatment program in patients with symptomatic knee osteoarthritis (OA). Methods Patients with symptomatic, radiographically confirmed knee OA resistant to traditional conservative treatments underwent a supervised 8-week multimodal treatment program consisting of low-impact aerobic exercise, muscle flexibility exercises, joint mobilization, physical therapy modalities, muscle strengthening and functional training, patient education, and a series of 3 or 5 weekly hyaluronic acid injections. Patients were evaluated at admission, 4 weeks, and 8 weeks. Patient-reported outcomes included knee pain severity using an 11-point (0–10) numerical scale and the Western Ontario and McMaster Universities Osteoarthritis Index. Results A total of 3,569 patients completed an 8-week treatment course between January 2008 and April 2013 at 66 dedicated treatment centers in the United States. Knee pain severity assessed on a numeric scale decreased 59% on average, from 5.4±2.9 to 2.2±2.2 (P<0.001). Western Ontario and McMaster Universities Osteoarthritis Index subscores decreased by 44% to 51% (all P<0.001) during the 8-week program. The percentage of patients achieving the threshold for Western Ontario and McMaster Universities Osteoarthritis Index minimally perceptible clinical improvement was 79% for the Pain subscale, 75% for Function, and 76% for Stiffness. Favorable patient outcomes were reported in all subgroups, regardless of age, sex, body mass index, disease severity, or number of treatment cycles. Discussion A real-world 8-week multimodal treatment program results in clinically meaningful improvements in knee OA symptoms, with excellent generalizability across a broad range of patient characteristics. PMID:27774023

Services Acquisition in the Department of Defense: Analysis of Operational and Performance Data to Identify Drivers of Success

DTIC Science & Technology

2015-03-24

improving the disclosure of CPARS program office Audit results (Black et al., 2014, pp. 48–49). Acquisition Research Program Graduate School of...improving the disclosure of CPARS program office audit results (Black et al., 2014, pp. 44–49). Recommendations Based on our conclusions, we identified...Fitzsimmons, J. A., & Fitzsimmons, M. J. (2006). Service management: Operations, strategy, and information technology (5th ed.). New York, NY: McGraw -Hill

The evaluation of a food allergy and epinephrine autoinjector training program for personnel who care for children in schools and community settings.

PubMed

Wahl, Ann; Stephens, Hilary; Ruffo, Mark; Jones, Amanda L

2015-04-01

With the dramatic increase in the incidence of food allergies, nurses and other school personnel are likely to encounter a child with food allergies. The objectives of this study were to assess the effectiveness of in-person training on enhancing knowledge about food allergies and improving self-confidence in preventing, recognizing, and treating food allergy reactions and to collect information about prior training and participation in response to food allergy incidents. A total of 4,818 individuals at 247 schools and community sites participated in the training program, which was delivered by a licensed registered nurse. Written evaluations, online surveys, and phone interviews were used to measure the impact including content retention, confidence, and behavior changes. The results of this study show that in-person training can increase participant's knowledge about food allergies and improve self-confidence in preventing, recognizing, and treating allergic reactions and that these gains were sustained over time. © The Author(s) 2014.

Effective Reading Programs for Middle and High Schools: A Best-Evidence Synthesis. Educator's Summary

ERIC Educational Resources Information Center

Center for Data-Driven Reform in Education (NJ3), 2008

2008-01-01

What reading programs have been proven to help middle and high school students to succeed? To find out, this review summarizes evidence on four types of programs designed to improve the reading achievement of students in grades 6-12: (1) Reading Curricula (Curr), such as "LANGUAGE!," "McDougal Littel," and other standard and alternative textbooks;…

Efficient Implementation of MrBayes on Multi-GPU

PubMed Central

Zhou, Jianfu; Liu, Xiaoguang; Wang, Gang

2013-01-01

MrBayes, using Metropolis-coupled Markov chain Monte Carlo (MCMCMC or (MC)3), is a popular program for Bayesian inference. As a leading method of using DNA data to infer phylogeny, the (MC)3 Bayesian algorithm and its improved and parallel versions are now not fast enough for biologists to analyze massive real-world DNA data. Recently, graphics processor unit (GPU) has shown its power as a coprocessor (or rather, an accelerator) in many fields. This article describes an efficient implementation a(MC)3 (aMCMCMC) for MrBayes (MC)3 on compute unified device architecture. By dynamically adjusting the task granularity to adapt to input data size and hardware configuration, it makes full use of GPU cores with different data sets. An adaptive method is also developed to split and combine DNA sequences to make full use of a large number of GPU cards. Furthermore, a new “node-by-node” task scheduling strategy is developed to improve concurrency, and several optimizing methods are used to reduce extra overhead. Experimental results show that a(MC)3 achieves up to 63× speedup over serial MrBayes on a single machine with one GPU card, and up to 170× speedup with four GPU cards, and up to 478× speedup with a 32-node GPU cluster. a(MC)3 is dramatically faster than all the previous (MC)3 algorithms and scales well to large GPU clusters. PMID:23493260

Efficient implementation of MrBayes on multi-GPU.

PubMed

Bao, Jie; Xia, Hongju; Zhou, Jianfu; Liu, Xiaoguang; Wang, Gang

2013-06-01

MrBayes, using Metropolis-coupled Markov chain Monte Carlo (MCMCMC or (MC)(3)), is a popular program for Bayesian inference. As a leading method of using DNA data to infer phylogeny, the (MC)(3) Bayesian algorithm and its improved and parallel versions are now not fast enough for biologists to analyze massive real-world DNA data. Recently, graphics processor unit (GPU) has shown its power as a coprocessor (or rather, an accelerator) in many fields. This article describes an efficient implementation a(MC)(3) (aMCMCMC) for MrBayes (MC)(3) on compute unified device architecture. By dynamically adjusting the task granularity to adapt to input data size and hardware configuration, it makes full use of GPU cores with different data sets. An adaptive method is also developed to split and combine DNA sequences to make full use of a large number of GPU cards. Furthermore, a new "node-by-node" task scheduling strategy is developed to improve concurrency, and several optimizing methods are used to reduce extra overhead. Experimental results show that a(MC)(3) achieves up to 63× speedup over serial MrBayes on a single machine with one GPU card, and up to 170× speedup with four GPU cards, and up to 478× speedup with a 32-node GPU cluster. a(MC)(3) is dramatically faster than all the previous (MC)(3) algorithms and scales well to large GPU clusters.

The Ph.D. Pipeline: McNair Program Cuts Could Hamper Efforts to Boost Number of Minorities Holding Doctoral Degrees

ERIC Educational Resources Information Center

Abdul-Alim, Jamaal

2012-01-01

This article features the Ronald E. McNair Postbaccalaureate Achievement Program at the University of Memphis. The McNair program is named after Ronald E. McNair, the second African-American in space, who died in the Space Shuttle Challenger explosion in 1986. Approximately 200 campuses across the nation host the program. Whereas the program…

A Behaviorally-Oriented Residential Camping Program for Obese Children and Adolescents.

ERIC Educational Resources Information Center

McKenzie, Thomas L.

1986-01-01

Behavioral strategies were used to teach exercise and weight control habits, and were combined with diet planning, nutrition education, and a strenuous physical education program in a residential summer camp, to successfully bring about a significant reduction in body fat and heart disease risk of obese boys, 8-18 years old. (Author/JDD)

Development of a Residential Education Program for Emotionally Deprived Pseudo-Retarded Blind Children, Volumes II and III. Final Report.

ERIC Educational Resources Information Center

Rigby, Mary E.; Woodcock, Charles C.

A continuation of a report (EC 004 818) presents appended case studies of 15 children involved in a residential school program for the multiply handicapped blind. Each study provides information and developmental history, medical data, personal hygiene, eating habits, physical development, psychological adjustment, object recognition, classroom…

Monte Carlo simulations of neutron-scattering instruments using McStas

NASA Astrophysics Data System (ADS)

Nielsen, K.; Lefmann, K.

2000-06-01

Monte Carlo simulations have become an essential tool for improving the performance of neutron-scattering instruments, since the level of sophistication in the design of instruments is defeating purely analytical methods. The program McStas, being developed at Risø National Laboratory, includes an extension language that makes it easy to adapt it to the particular requirements of individual instruments, and thus provides a powerful and flexible tool for constructing such simulations. McStas has been successfully applied in such areas as neutron guide design, flux optimization, non-Gaussian resolution functions of triple-axis spectrometers, and time-focusing in time-of-flight instruments.

Neuro-Cognitive Intervention for Working Memory: Preliminary Results and Future Directions.

PubMed

Bree, Kathleen D; Beljan, Paul

2016-01-01

Definitions of working memory identify it as a function of the executive function system in which an individual maintains two or more pieces of information in mind and uses that information simultaneously for some purpose. In academics, working memory is necessary for a variety of functions, including attending to the information one's teacher presents and then using that information simultaneously for problem solving. Research indicates difficulties with working memory are observed in children with mathematics learning disorder (MLD) and reading disorders (RD). To improve working memory and other executive function difficulties, and as an alternative to medication treatments for attention and executive function disorders, the Motor Cognition(2)® (MC(2)®)program was developed. Preliminary research on this program indicates statistically significant improvements in working memory, mathematics, and nonsense word decoding for reading. Further research on the MC(2)® program and its impact on working memory, as well as other areas of executive functioning, is warranted.

Educational and Employment Outcomes of Ronald E. McNair Postbaccalaureate Achievement Program Alumni

ERIC Educational Resources Information Center

McCoy, Ann; Wilkinson, Anna; Jackson, Russell

2008-01-01

This report presents findings from a study of the Ronald E. McNair Postbaccaulaureate Achievement (McNair) Program. The McNair Program was established in 1986 to increase the attainment of doctoral degrees by students from disadvantaged and underrepresented backgrounds. This study is a descriptive analysis of participant outcomes: no attempt is…

HC/MC-130 Recapitalization Aircraft (HC/MC-130 Recap)

DTIC Science & Technology

2015-12-01

Selected Acquisition Report ( SAR ) RCS: DD-A&T(Q&A)823-257 HC/MC-130 Recapitalization Aircraft (HC/MC-130 Recap) As of FY 2017 President’s Budget...Defense Acquisition Management Information Retrieval (DAMIR) March 18, 2016 08:18:54 UNCLASSIFIED HC/MC-130 Recap December 2015 SAR March 18, 2016...Recap December 2015 SAR March 18, 2016 08:18:54 UNCLASSIFIED 3 PB - President’s Budget PE - Program Element PEO - Program Executive Officer PM - Program

Airport Revenues: McMahon-Wrinkle Airpark; Big Spring, Texas

DOT National Transportation Integrated Search

1997-11-21

Audit objectives were to determine whether the city of Big Spring, Texas : (city), was in compliance with the Federal Aviation Administration (FAA) Airport : Improvement Program grant assurances to ensure (i) fee and rental structures were maintained...

LED Lighting in a Performing Arts Building

DOE Office of Scientific and Technical Information (OSTI.GOV)

Miller, N. J.; Kaye, S. M.; Coleman, P. M.

At the University of Florida in Gainesville, the DOE Solid-State Lighting GATEWAY program evaluated LED architectural and theatrical lighting in four academic/performance-related spaces within the Nadine McGuire Theatre + Dance Pavilion. Due to a wise choice of products and luminaire light distributions, the change brought significant quality improvements including improved controllability and color.

26 CFR 1.818-2 - Accounting provisions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Accounting provisions. 1.818-2 Section 1.818-2...) INCOME TAXES Miscellaneous Provisions § 1.818-2 Accounting provisions. (a) Method of accounting. (1... accounting. Thus, the over-all method of accounting for life insurance companies shall be the accrual method...

MO-E-18C-02: Hands-On Monte Carlo Project Assignment as a Method to Teach Radiation Physics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pater, P; Vallieres, M; Seuntjens, J

2014-06-15

Purpose: To present a hands-on project on Monte Carlo methods (MC) recently added to the curriculum and to discuss the students' appreciation. Methods: Since 2012, a 1.5 hour lecture dedicated to MC fundamentals follows the detailed presentation of photon and electron interactions. Students also program all sampling steps (interaction length and type, scattering angle, energy deposit) of a MC photon transport code. A handout structured in a step-by-step fashion guides student in conducting consistency checks. For extra points, students can code a fully working MC simulation, that simulates a dose distribution for 50 keV photons. A kerma approximation to dosemore » deposition is assumed. A survey was conducted to which 10 out of the 14 attending students responded. It compared MC knowledge prior to and after the project, questioned the usefulness of radiation physics teaching through MC and surveyed possible project improvements. Results: According to the survey, 76% of students had no or a basic knowledge of MC methods before the class and 65% estimate to have a good to very good understanding of MC methods after attending the class. 80% of students feel that the MC project helped them significantly to understand simulations of dose distributions. On average, students dedicated 12.5 hours to the project and appreciated the balance between hand-holding and questions/implications. Conclusion: A lecture on MC methods with a hands-on MC programming project requiring about 14 hours was added to the graduate study curriculum since 2012. MC methods produce “gold standard” dose distributions and slowly enter routine clinical work and a fundamental understanding of MC methods should be a requirement for future students. Overall, the lecture and project helped students relate crosssections to dose depositions and presented numerical sampling methods behind the simulation of these dose distributions. Research funding from governments of Canada and Quebec. PP acknowledges partial support by the CREATE Medical Physics Research Training Network grant of the Natural Sciences and Engineering Research Council (Grant number: 432290)« less

Root Cause Analyses of Nunn-McCurdy Breaches. Volume 2: Excalibur Artillery Projectile and the Navy Enterprise Resource Planning Program, with an Approach to Analyzing Program Complexity and Risk

DTIC Science & Technology

2012-01-01

The mismatch, it was feared, would wreck the processes that the ERP was trying to improve; customers did not have the choice of putting the ERP...program features ahead of attempting a deep dive into the data looking for problems. An initial conceptual framework would allow a decision- maker to

Rational mutagenesis by engineering disulphide bonds improves Kluyveromyces lactis beta-galactosidase for high-temperature industrial applications

PubMed Central

Rico-Díaz, Agustín; Álvarez-Cao, María-Efigenia; Escuder-Rodríguez, Juan-José; González-Siso, María-Isabel; Cerdán, M. Esperanza; Becerra, Manuel

2017-01-01

Kluyveromyces lactis β-galactosidase (Kl-β-Gal) is one of the most important enzymes in the dairy industry. The poor stability of this enzyme limits its use in the synthesis of galactooligosaccharides (GOS) and other applications requiring high operational temperature. To obtain thermoresistant variants, a rational mutagenesis strategy by introducing disulphide bonds in the interface between the enzyme subunits was used. Two improved mutants, R116C/T270C and R116C/T270C/G818C, had increased half-lives at 45 °C compared to Kl-β-Gal (2.2 and 6.8 fold increases, respectively). Likewise, Tm values of R116C/T270C and R116C/T270C/G818C were 2.4 and 8.5 °C, respectively, higher than Kl-β-Gal Tm. Enrichment in enzymatically active oligomeric forms in these mutant variants also increased their catalytic efficiency, due to the reinforcement of the interface contacts. In this way, using an artificial substrate (p-nitrophenyl-β-D-galactopyranoside), the Vmax values of the mutants were ~1.4 (R116C/T270C) and 2 (R116C/T270C/G818C) fold higher than that of native Kl-β-Gal. Using the natural substrate (lactose) the Vmax for R116C/T270C/G818C almost doubled the Vmax for Kl-β-Gal. Validation of these mutant variants of the enzyme for their use in applications that depend on prolonged incubations at high temperatures was achieved at the laboratory scale by monitoring their catalytic activity in GOS synthesis. PMID:28361909

Rational mutagenesis by engineering disulphide bonds improves Kluyveromyces lactis beta-galactosidase for high-temperature industrial applications.

PubMed

Rico-Díaz, Agustín; Álvarez-Cao, María-Efigenia; Escuder-Rodríguez, Juan-José; González-Siso, María-Isabel; Cerdán, M Esperanza; Becerra, Manuel

2017-03-31

Kluyveromyces lactis β-galactosidase (Kl-β-Gal) is one of the most important enzymes in the dairy industry. The poor stability of this enzyme limits its use in the synthesis of galactooligosaccharides (GOS) and other applications requiring high operational temperature. To obtain thermoresistant variants, a rational mutagenesis strategy by introducing disulphide bonds in the interface between the enzyme subunits was used. Two improved mutants, R116C/T270C and R116C/T270C/G818C, had increased half-lives at 45 °C compared to Kl-β-Gal (2.2 and 6.8 fold increases, respectively). Likewise, Tm values of R116C/T270C and R116C/T270C/G818C were 2.4 and 8.5 °C, respectively, higher than Kl-β-Gal Tm. Enrichment in enzymatically active oligomeric forms in these mutant variants also increased their catalytic efficiency, due to the reinforcement of the interface contacts. In this way, using an artificial substrate (p-nitrophenyl-β-D-galactopyranoside), the Vmax values of the mutants were ~1.4 (R116C/T270C) and 2 (R116C/T270C/G818C) fold higher than that of native Kl-β-Gal. Using the natural substrate (lactose) the Vmax for R116C/T270C/G818C almost doubled the Vmax for Kl-β-Gal. Validation of these mutant variants of the enzyme for their use in applications that depend on prolonged incubations at high temperatures was achieved at the laboratory scale by monitoring their catalytic activity in GOS synthesis.

4 CFR 81.8 - Public reading facility.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 4 Accounts 1 2014-01-01 2013-01-01 true Public reading facility. 81.8 Section 81.8 Accounts GOVERNMENT ACCOUNTABILITY OFFICE RECORDS PUBLIC AVAILABILITY OF GOVERNMENT ACCOUNTABILITY OFFICE RECORDS § 81.8 Public reading facility. GAO maintains a public reading facility in the Law Library at the Government Accountability Office Building, 441 G...

4 CFR 81.8 - Public reading facility.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 4 Accounts 1 2013-01-01 2013-01-01 false Public reading facility. 81.8 Section 81.8 Accounts GOVERNMENT ACCOUNTABILITY OFFICE RECORDS PUBLIC AVAILABILITY OF GOVERNMENT ACCOUNTABILITY OFFICE RECORDS § 81.8 Public reading facility. GAO maintains a public reading facility in the Law Library at the Government Accountability Office Building, 441 G...

4 CFR 81.8 - Public reading facility.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 4 Accounts 1 2012-01-01 2012-01-01 false Public reading facility. 81.8 Section 81.8 Accounts GOVERNMENT ACCOUNTABILITY OFFICE RECORDS PUBLIC AVAILABILITY OF GOVERNMENT ACCOUNTABILITY OFFICE RECORDS § 81.8 Public reading facility. GAO maintains a public reading facility in the Law Library at the Government Accountability Office Building, 441 G...

49 CFR 178.818 - Tear test.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 2 2010-10-01 2010-10-01 false Tear test. 178.818 Section 178.818 Transportation... § 178.818 Tear test. (a) General. The tear test must be conducted for the qualification of all flexible IBC design types. (b) Special preparation for the tear test. The flexible IBC must be filled to not...

46 CFR 15.818 - Global Maritime Distress and Safety System (GMDSS) at-sea maintainer.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 1 2014-10-01 2014-10-01 false Global Maritime Distress and Safety System (GMDSS) at-sea maintainer. 15.818 Section 15.818 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MERCHANT MARINE OFFICERS AND SEAMEN MANNING REQUIREMENTS Computations § 15.818 Global Maritime Distress and Safety...

Monolithic and bi-layer CAD/CAM lithium-disilicate versus metal-ceramic fixed dental prostheses: comparison of fracture loads and failure modes after fatigue.

PubMed

Schultheis, Stefan; Strub, Joerg R; Gerds, Thomas A; Guess, Petra C

2013-06-01

The authors analyzed the effect of fatigue on the survival rate and fracture load of monolithic and bi-layer CAD/CAM lithium-disilicate posterior three-unit fixed dental prostheses (FDPs) in comparison to the metal-ceramic gold standard. The authors divided 96 human premolars and molars into three equal groups. Lithium-disilicate ceramic (IPS-e.max-CAD) was milled with the CEREC-3-system in full-anatomic FDP dimensions (monolithic: M-LiCAD) or as framework (Bi-layer: BL-LiCAD) with subsequent hand-layer veneering. Metal-ceramic FDPs (MC) served as control. Single-load-to-failure tests were performed before and after mouth-motion fatigue. No fracture failures occurred during fatigue. Median fracture loads in [N], before and after fatigue were, respectively, as follows: M-LiCAD, 1,298/1,900; BL-LiCAD, 817/699; MC, 1,966/1,818. M-LiCAD and MC FPDs revealed comparable fracture loads and were both significantly higher than BL-LiCAD. M-LiCAD and BL-LiCAD both failed from core/veneer bulk fracture within the connector area. MC failures were limited to ceramic veneer fractures exposing the metal core. Fatigue had no significant effect on any group. Posterior monolithic CAD/CAM fabricated lithium-disilicate FPDs were shown to be fracture resistant with failure load results comparable to the metal-ceramic gold standard. Clinical investigations are needed to confirm these promising laboratory results. Monolithic CAD/CAM fabricated lithium-disilicate FDPs appeared to be a reliable treatment alternative for the posterior load-bearing area, whereas FDPs in bi-layer configuration were susceptible to low load fracture failure.

Graduate School Learning Curves: McNair Scholars' Postbaccalaureate Transitions

ERIC Educational Resources Information Center

Willison, Scott; Gibson, Emily

2011-01-01

The federally funded Ronald B. McNair Postbaccalaureate Achievement Program (McNair Program) prepares first-generation, low-income, and underrepresented college undergraduates to pursue terminal graduate degrees. This study examines 22 McNair scholars' transitions into graduate school in an attempt to identify factors that influence alumni…

McClellan AFB, California, RI/FS Quality Assurance Project Plan. Installation Restoration Program (IRP) Stage 3.

DTIC Science & Technology

1992-08-07

AD-A5 6 ... 1... . .. .. .... INSTALLATION RESTORATION PROGRAM (IRP) STAGE 3 7m~ QUALITY ASSURANCE -k- PROJECT PLAN for McCLELLAN AFB , CALIFORNIA...FINAL.. S AUG 2. 1 1992 L PREPARED FOR: .... ... McCLELLAN AFB IEM McCLELLAN AFB , CALIFORNIA 9652-599 ................... fr pu licrele se...PLAN FINAL ’’ : " FOR McCLELLAN AFB /EM McCLELLAN AFB , CALIFORNIA 95652-5990 August 1992 AUG 2 11992 PREPARED BY: DI Radian Corporation10389 Old

Report of the AAPM Task Group No. 105: Issues associated with clinical implementation of Monte Carlo-based photon and electron external beam treatment planning.

PubMed

Chetty, Indrin J; Curran, Bruce; Cygler, Joanna E; DeMarco, John J; Ezzell, Gary; Faddegon, Bruce A; Kawrakow, Iwan; Keall, Paul J; Liu, Helen; Ma, C M Charlie; Rogers, D W O; Seuntjens, Jan; Sheikh-Bagheri, Daryoush; Siebers, Jeffrey V

2007-12-01

The Monte Carlo (MC) method has been shown through many research studies to calculate accurate dose distributions for clinical radiotherapy, particularly in heterogeneous patient tissues where the effects of electron transport cannot be accurately handled with conventional, deterministic dose algorithms. Despite its proven accuracy and the potential for improved dose distributions to influence treatment outcomes, the long calculation times previously associated with MC simulation rendered this method impractical for routine clinical treatment planning. However, the development of faster codes optimized for radiotherapy calculations and improvements in computer processor technology have substantially reduced calculation times to, in some instances, within minutes on a single processor. These advances have motivated several major treatment planning system vendors to embark upon the path of MC techniques. Several commercial vendors have already released or are currently in the process of releasing MC algorithms for photon and/or electron beam treatment planning. Consequently, the accessibility and use of MC treatment planning algorithms may well become widespread in the radiotherapy community. With MC simulation, dose is computed stochastically using first principles; this method is therefore quite different from conventional dose algorithms. Issues such as statistical uncertainties, the use of variance reduction techniques, the ability to account for geometric details in the accelerator treatment head simulation, and other features, are all unique components of a MC treatment planning algorithm. Successful implementation by the clinical physicist of such a system will require an understanding of the basic principles of MC techniques. The purpose of this report, while providing education and review on the use of MC simulation in radiotherapy planning, is to set out, for both users and developers, the salient issues associated with clinical implementation and experimental verification of MC dose algorithms. As the MC method is an emerging technology, this report is not meant to be prescriptive. Rather, it is intended as a preliminary report to review the tenets of the MC method and to provide the framework upon which to build a comprehensive program for commissioning and routine quality assurance of MC-based treatment planning systems.

USGS research on mineral resources, 1985 program and abstracts

USGS Publications Warehouse

Krafft, Kathleen

1985-01-01

The extended abstracts in this volume are summaries of the papers presented orally and as posters in the first V.E. McKelvey Forum on Mineral and Energy Resources, entitled "USGS Research on Mineral Resources-1985." The Forum has been established to improve communication between the USGS and the earth science community by presenting the results of current USGS research on nonrenewable resources in a timely fashion and by providing an opportunity for individuals from other organizations to meet informally with USGS scientists and managers. It is our hope that the McKelvey Forum will help to make USGS programs more responsive to the needs of the earth science community, particularly the mining and petroleum industries, and will foster closer cooperation between organizations and individuals.

34 CFR 647.1 - What is the Ronald E. McNair Postbaccalaureate Achievement Program?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 3 2010-07-01 2010-07-01 false What is the Ronald E. McNair Postbaccalaureate... (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION RONALD E. MCNAIR POSTBACCALAUREATE ACHIEVEMENT PROGRAM General § 647.1 What is the Ronald E. McNair Postbaccalaureate Achievement Program? The...

The McNair Scholars Program as an Agent of Socialization in the Doctoral Experience

ERIC Educational Resources Information Center

Gittens, Cheryl Bailey

2013-01-01

Interventions such as the Ronald E. McNair Post-Baccalaureate Achievement Program (McNair Scholars Program) are among the national strategies for promoting doctoral degree attainment amongst first-generation college students from low socioeconomic backgrounds or groups underrepresented in graduate education. This study aimed to understand how…

Psychiatric service utilization and cost for persons with schizophrenia in a Medicaid managed care program.

PubMed

Rothbard, Aileen B; Kuno, Eri; Hadley, Trevor R; Dogin, Judith

2004-01-01

A pre-post study design was used to look at changes in behavioral health care services and costs for Medicaid-eligible individuals with schizophrenia in a managed care (MC) carve-out compared to a fee-for-service (FFS) program in Pennsylvania between 1995 and 1998. Statistically significant reductions of 59% were found in hospital expenditures in the MC program compared to 18.3% in the FFS program. The decline in hospital costs was due to dramatic fee reductions in the MC site. No significant differences in overall ambulatory utilization were found in either program; however, ambulatory expenditures rose 57% in the MC program versus a decline of 11% in fee for service. The ambulatory cost increase resulted from a cost shift between county block grant funds, and Medicaid funds, with no additional revenues provided to outpatient providers. Study implications are that cost reductions from MC are mainly due to reducing utilization and payments to hospitals, similar to the findings for private sector programs.

Geothermal well site restoration and plug and abandonment of wells, DOE Gladys McCall test site, Cameron Parish, Louisiana and DOE Willis Hulin test site, Vermillion Parish, Louisiana

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rinehart, Ben N.

1994-08-01

A report is presented on the final phase of an energy research program conducted by the U.S. Department of Energy (DOE) involving two geothermal well sites in the State of Louisiana--the Gladys McCall site and the Willis Hulin site. The research program was intended to improve geothermal technology and to determine the efficacy of producing electricity commercially from geopressured resource sites. The final phase of the program consisted of plug and abandonment (P&A) of the wells and restoration of the well sites. Restoration involved (a) initial soil and water sampling and analysis; (b) removal and disposal of well pads, concrete,more » utility poles, and trash; (c) plugging of monitor and freshwater wells; and (d) site leveling and general cleanup. Restoration of the McCall site required removal of naturally occurring radioactive material (NORM), which was costly and time-consuming. Exhibits are included that provide copies of work permits and authorizations, P&A reports, and cost and salvage reports. Site locations, grid maps, and photographs are provided.« less

Therapy in the Mountains.

ERIC Educational Resources Information Center

Kennison, Judith A.

This paper describes experiences from a summer internship in a North Carolina wilderness program for youth 8-18 years of age with a diagnosed learning disability or Attention Deficit Disorder (ADD). Children with ADD are trial and error learners, which makes them excellent candidates for experiential learning. Children with ADD are seekers of…

7 CFR 81.8 - Application and approval for participation.

Code of Federal Regulations, 2011 CFR

2011-01-01

... office personnel. (b) Applications for participation in the Prune-Plum Diversion Program can be obtained... in question, and/or as needed, the statement must show an agreement to participate in the tree... the tree removal. However, obtaining such assent shall be the responsibility of the applicant who...

7 CFR 81.8 - Application and approval for participation.

Code of Federal Regulations, 2013 CFR

2013-01-01

... office personnel. (b) Applications for participation in the Prune-Plum Diversion Program can be obtained... in question, and/or as needed, the statement must show an agreement to participate in the tree... the tree removal. However, obtaining such assent shall be the responsibility of the applicant who...

7 CFR 81.8 - Application and approval for participation.

Code of Federal Regulations, 2014 CFR

2014-01-01

... office personnel. (b) Applications for participation in the Prune-Plum Diversion Program can be obtained... in question, and/or as needed, the statement must show an agreement to participate in the tree... the tree removal. However, obtaining such assent shall be the responsibility of the applicant who...

7 CFR 81.8 - Application and approval for participation.

Code of Federal Regulations, 2012 CFR

2012-01-01

... office personnel. (b) Applications for participation in the Prune-Plum Diversion Program can be obtained... in question, and/or as needed, the statement must show an agreement to participate in the tree... the tree removal. However, obtaining such assent shall be the responsibility of the applicant who...

McGovern-Dole International Food for Education and Child Nutrition Program. Fact Sheet

ERIC Educational Resources Information Center

US Department of Agriculture, 2009

2009-01-01

The McGovern-Dole International Food for Education and Child Nutrition Program (McGovern-Dole program) helps support education, child development, and food security for some of the world's poorest children. It provides for donations of U.S. agricultural products, as well as financial and technical assistance, for school feeding and maternal and…

Field Tests of In-Service Modifications to Improve Performance of An Icebreaker Main Diesel Engine

DOT National Transportation Integrated Search

1977-08-01

Field tests of in-service modifications to improve engine efficiency and lower the emissions were performed on the no. 3 main diesel engine of the USCGC Mackinaw (WAGB-83). This engine is a model 38D8-1/8 manufactured by Colt Industries, Fairbanks Mo...

Root carboxylate exudation capacity under phosphorus stress does not improve grain yield in green gram.

PubMed

Pandey, Renu; Meena, Surendra Kumar; Krishnapriya, Vengavasi; Ahmad, Altaf; Kishora, Naval

2014-06-01

Genetic variability in carboxylate exudation capacity along with improved root traits was a key mechanism for P-efficient green gram genotype to cope with P-stress but it did not increase grain yield. This study evaluates genotypic variability in green gram for total root carbon exudation under low phosphorus (P) using (14)C and its relationship with root exuded carboxylates, growth and yield potential in contrasting genotypes. Forty-four genotypes grown hydroponically with low (2 μM) and sufficient (100 μM) P concentrations were exposed to (14)CO2 to screen for total root carbon exudation. Contrasting genotypes were employed to study carboxylate exudation and their performance in soil at two P levels. Based on relative (14)C exudation and biomass, genotypes were categorized. Carboxylic acids were measured in exudates and root apices of contrasting genotypes belonging to efficient and inefficient categories. Oxalic and citric acids were released into the medium under low-P. PDM-139 (efficient) was highly efficient in carboxylate exudation as compared to ML-818 (inefficient). In low soil P, the reduction in biomass was higher in ML-818 as compared to PDM-139. Total leaf area and photosynthetic rate averaged for genotypes increased by 71 and 41 %, respectively, with P fertilization. Significantly, higher root surface area and volume were observed in PDM-139 under low soil P. Though the grain yield was higher in ML-818, the total plant biomass was significantly higher in PDM-139 indicating improved P uptake and its efficient translation into biomass. The higher carboxylate exudation capacity and improved root traits in the later genotype might be the possible adaptive mechanisms to cope with P-stress. However, it is not necessary that higher root exudation would result in higher grain yield.

Male circumcision to prevent syphilis in 1855 and HIV in 1986 is supported by the accumulated scientific evidence to 2015: Response to Darby.

PubMed

Morris, Brian J; Wamai, Richard G; Krieger, John N; Banerjee, Joya; Klausner, Jeffrey D

2017-10-01

An article by Darby disparaging male circumcision (MC) for syphilis prevention in Victorian times (1837-1901) and voluntary medical MC programs for HIV prevention in recent times ignores contemporary scientific evidence. It is one-sided and cites outlier studies as well as claims by MC opponents that support the author's thesis, but ignores high quality randomised controlled trials and meta-analyses. While we agree with Darby that risky behaviours contribute to syphilis and HIV epidemics, there is now compelling evidence that MC helps reduce both syphilis and HIV infections. Although some motivations for MC in Victorian times were misguided, others, such as protection against syphilis, penile cancer, phimosis, balanitis and poor hygiene have stood the test of time. In the absence of a cure or effective prophylactic vaccine for HIV, MC should help lower heterosexually acquired HIV, especially when coupled with other interventions such as condoms and behaviour. This should save lives, as well as reducing costs and suffering. In contrast to Darby, our evaluation of the evidence leads us to conclude that MC would likely have helped reduce syphilis in Victorian times and, in the current era, will help lower both syphilis and HIV, so improving global public health.

Needs assessment of school and community physical activity opportunities in rural West Virginia: the McDowell CHOICES planning effort.

PubMed

Kristjansson, Alfgeir L; Elliott, Eloise; Bulger, Sean; Jones, Emily; Taliaferro, Andrea R; Neal, William

2015-04-03

McDowell CHOICES (Coordinated Health Opportunities Involving Communities, Environments, and Schools) Project is a county wide endeavor aimed at increasing opportunities for physical activity (PA) in McDowell County, West Virginia (WV). A comprehensive needs-assessment laid the foundation of the project. During the 6 month needs assessment, multiple sources of data were collected in two Town Hall Meetings (n = 80); a student online PA interest survey (n = 465); a PA and nutrition survey among 5(th) (10-11 years) and 8(th) graders (13-14 years) with questions adapted from the CDC's Youth Risk Behavior Surveillance Survey (n = 442, response rate = 82.2%); six semi-structured school and community focus groups (n = 44); school site visits (n = 11); and BMI screening (n = 550, response rate = 69.7%). One third of children in McDowell County meet the national PA minimum of 60 minutes daily. At least 40% of 5(th) and 8(th) graders engage in electronic screen activity for 3 hours or more every day. The prevalence of obesity in 5(th) graders is higher in McDowell County than the rest of WV (~55% vs. 47% respectively). SWOT analyses of focus group data suggest an overall interest in PA but also highlight a need for increase in structured PA opportunities. Focus group data also suggested that a central communication (e.g. internet-based) platform would be beneficial to advertise and boost participation both in current and future programs. Schools were commonly mentioned as potential facilities for public PA participation throughout the county, both with regards to access and convenience. School site visits suggest that schools need more equipment and resources for before, during, and after school programs. An overwhelming majority of participants in the McDowell CHOICES needs assessment were interested to participate in more PA programs throughout the county as well as to improve opportunities for the provision of such programs. Public schools were widely recognized as the hub of the communities and provide the best venue for PA promotion for both students and adult citizens, and can potentially serve as a platform for change in rural communities such as McDowell County.

Cytokeratin 5/6 and cytokeratin 8/18 expression in triple negative breast cancers: clinicopathologic significance in South-Asian population.

PubMed

Hashmi, Atif Ali; Naz, Samreen; Hashmi, Shumaila Kanwal; Hussain, Zubaida Fida; Irfan, Muhammad; Bakar, Syed Muhammad Abu; Faridi, Naveen; Khan, Amir; Edhi, Muhammad Muzzammil

2018-06-08

Cytokeratin 5/6 and Cytokeratin 8/18 are basal and luminal markers of breast cancer and they have pathological and prognostic significance in breast cancer. We performed Cytokeratin 5/6 and CK8/18 immunohistochemistry on 150 cases of triple negative breast cancers and association with various clinicopathological features was evaluated. Positive CK5/6 expression was noted in 8% (12 cases) of TNBC while 2.4% (4 cases) showed focal positive (< 10%) and 89.3% (134) were negative with CK5/6. Complete loss of CK8/18 expression was seen in 4.7% (7 cases) while 32.7% (49 cases) revealed focal loss of CK8/18 and 62.7% (94 cases) showed intact normal expression of CK8/18. No significant association of CK5/6 and CK8/18 with various clinicopathological parameters was observed. We found a low expression of basal cytokeratin (CK5/6) in TNBC our studied population, while loss/altered expression of CK8/18 in approximately 38% of TNBC. Although no prognostic relevance of these finding was noted in our study, however these findings are different from those reported in literature in other parts of the world. Therefore we suggest a more through immunohistochemical and genomic profiling of TNBC in our population for better understanding of this disease in this part of the world.

Counter-Attrition Programs in the United States Armed Forces

DTIC Science & Technology

1984-07-01

the average pretest - posttest improvement of ART students on the Gates-MacGinitie Reading Test was 2.5 RGL. No comparison control group change scores...retraining programs, elaborate quasi - experimentation could be readily built Into the existing operational system. Every major installation has one or more...research on teach-n. Chicago: Rand McNally, 1963, pp. 171-246. Reprinted as Experimental and quasi - experimental designs for research. Chicago: Rand

Pulmonary Rehabilitation: Improvement with Movement.

PubMed

Rajagopal, Anita; Casaburi, Richard

2016-01-15

This article serves as a CME- available, enduring material summary of the following COPD9 USA presentations: - "Lessons Learned from Pulmonary Education Program and On Track with COPD Ongoing Health Management." Presenter : Scott Cerreta, BS, RRT - "Cultivating Memorial Funds for Pulmonary Rehabilitation" Presenter : Valerie McLeod, RRT - "Strategies for Success: Maintenance Program Best Practices" Presenter : David Vines, MHS, RRT - "Strategies for Success-Maximizing Participation and Completion Rates," Presenter : Trina M. Limberg, BS, RRT.

Residential Instability and the McKinney-Vento Homeless Children and Education Program: What We Know, Plus Gaps in Research

ERIC Educational Resources Information Center

Cunningham, Mary; Harwood, Robin; Hall, Sam

2010-01-01

As homelessness increased among families and children during the 1980s and 1990s, policymakers created, and strengthened, the McKinney-Vento Education for Homeless Children and Youth (EHCY) program. The McKinney-Vento EHCY program aims to mitigate the effects of residential instability through the identification of homeless children in schools and…

The Midlatitude Continental Convective Clouds Experiment (MC3E)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jensen, Mark P.; Petersen, Walt A.; Bansemer, Aaron

The Midlatitude Continental Convective Clouds Experiment (MC3E), a field program jointly led by the U.S. Department of Energy’s Atmospheric Radiation Measurement program and the NASA Global Precipitation Measurement (GPM) Mission, was conducted in south-central Oklahoma during April – May 2011. MC3E science objectives were motivated by the need to improve understanding of midlatitude continental convective cloud system lifecycles, microphysics, and GPM precipitation retrieval algorithms. To achieve these objectives a multi-scale surface- and aircraft-based in situ and remote sensing observing strategy was employed. A variety of cloud and precipitation events were sampled during the MC3E, of which results from three deepmore » convective events are highlighted. Vertical structure, air motions, precipitation drop-size distributions and ice properties were retrieved from multi-wavelength radar, profiler, and aircraft observations for an MCS on 11 May. Aircraft observations for another MCS observed on 20 May were used to test agreement between observed radar reflectivities and those calculated with forward-modeled reflectivity and microwave brightness temperatures using in situ particle size distributions and ice water content. Multi-platform observations of a supercell that occurred on 23 May allowed for an integrated analysis of kinematic and microphysical interactions. A core updraft of 25 ms-1 supported growth of hail and large rain drops. Data collected during the MC3E campaign is being used in a number of current and ongoing research projects and is available through the DOE ARM and NASA data archives.« less

Whole Language Learning for Elementary School Teachers, Children, and Parents.

ERIC Educational Resources Information Center

McCarthy, William G., Ed.; And Others

The purpose of this booklet is to disseminate theoretical ideas and practical strategies concerning whole language so that learning for children and practice for teaching may be enlightened and improved. Chapters include: "Whole Language Learning" (William McCarthy and Alicia Sutton); "Planning the Program and Organizing the Classroom" (Marilyn…

Texas-style Fundraising and Public Relations for the International Year of Astronomy

NASA Astrophysics Data System (ADS)

Preston, Sandra; Barna, J. W.; Geiger, S.; Johnson, R.; Rimm, N.; Griffin, J.; Watson, K.

2008-05-01

McDonald Observatory can be a leader in Texas for the International Year of Astronomy (IYA09) celebration. Our strategy builds on the IYA09 program, tailoring it for the Texas audience, while also nationally promoting McDonald Observatory, UT Astronomy, the Hobby-Eberly Telescope Dark Energy Experiment (HETDEX) and our partnership in the Giant Magellan Telescope (GMT). We will also use this opportunity to make a concentrated outreach effort toward the Hispanic and Spanish-speaking communities in Texas and the nation, aligning with the IYA09 objective for improving relations with underrepresented and minority populations. Fundraising is a key ingredient to our success in 2009 and the future. With NASA Office of Space Science funding for education and public outreach being rethought, we will be focusing on new sources for fundraising, including private donations and corporate sponsorship, augmented by planned giving. We will take advantage of the timing to raise funds for special IYA09 programs, as well as for our large telescope projects HETDEX and GMT, along with our endowment and planned giving programs for education, outreach, and research. We will work with the UT McCombs School of Business on corporate sponsorship. During this time we will also go through a branding experience that will visually unify McDonald Observatory, UT Astronomy, and the education and public outreach programs. A consistent brand that can be used on the website and other media is our goal to build a stronger public presence that will aid us in our fundraising efforts. A Public Relations Internship Project produced a report to help launch this process. We are working with the UT College of Communications Advertising Department and with Hill Strategic Brand Solutions in Houston, Texas. We hope that our efforts will produce Texas-sized results!

Using ARINC 818 Avionics Digital Video Bus (ADVB) for military displays

NASA Astrophysics Data System (ADS)

Alexander, Jon; Keller, Tim

2007-04-01

ARINC 818 Avionics Digital Video Bus (ADVB) is a new digital video interface and protocol standard developed especially for high bandwidth uncompressed digital video. The first draft of this standard, released in January of 2007, has been advanced by ARINC and the aerospace community to meet the acute needs of commercial aviation for higher performance digital video. This paper analyzes ARINC 818 for use in military display systems found in avionics, helicopters, and ground vehicles. The flexibility of ARINC 818 for the diverse resolutions, grayscales, pixel formats, and frame rates of military displays is analyzed as well as the suitability of ARINC 818 to support requirements for military video systems including bandwidth, latency, and reliability. Implementation issues relevant to military displays are presented.

Implementing quality/productivity improvement initiatives in an engineering environment

NASA Technical Reports Server (NTRS)

Ruda, R. R.

1985-01-01

Quality/Productivity Improvement (QPI) initiatives in the engineering environment at McDonnell Douglas-Houston include several different, distinct activities, each having its own application, yet all targeted toward one common goal - making continuous improvement a way of life. The chief executive and the next two levels of management demonstrate their commitment to QPI with hands-on involvement in several activities. Each is a member of a QPI Council which consists of six panels - Participative Management, Communications, Training, Performance/Productivity, Human Resources Management and Strategic Management. In addition, each manager conducts Workplace Visits and Bosstalks, to enhance communications with employees and to provide a forum for the identification of problems - both real and perceived. Quality Circles and Project Teams are well established within McConnel Douglas as useful and desirable employee involvement teams. The continued growth of voluntary membership in the circles program is strong evidence of the employee interest and management support that have developed within the organization.

49 CFR 236.818 - Switch, facing point.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Switch, facing point. 236.818 Section 236.818 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Switch, facing point. A switch, the points of which face traffic approaching in the direction for which...

49 CFR 236.818 - Switch, facing point.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 4 2012-10-01 2012-10-01 false Switch, facing point. 236.818 Section 236.818 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Switch, facing point. A switch, the points of which face traffic approaching in the direction for which...

49 CFR 236.818 - Switch, facing point.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 4 2013-10-01 2013-10-01 false Switch, facing point. 236.818 Section 236.818 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Switch, facing point. A switch, the points of which face traffic approaching in the direction for which...

49 CFR 236.818 - Switch, facing point.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 4 2011-10-01 2011-10-01 false Switch, facing point. 236.818 Section 236.818 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Switch, facing point. A switch, the points of which face traffic approaching in the direction for which...

49 CFR 236.818 - Switch, facing point.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 4 2014-10-01 2014-10-01 false Switch, facing point. 236.818 Section 236.818 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Switch, facing point. A switch, the points of which face traffic approaching in the direction for which...

Keratin 8 and 18 Loss in Epithelial Cancer Cells Increases Collective Cell Migration and Cisplatin Sensitivity through Claudin1 Up-regulation*

PubMed Central

Fortier, Anne-Marie; Asselin, Eric; Cadrin, Monique

2013-01-01

Keratins 8 and 18 (K8/18) are simple epithelial cell-specific intermediate filament proteins. Keratins are essential for tissue integrity and are involved in intracellular signaling pathways that regulate cell response to injuries, cell growth, and death. K8/18 expression is maintained during tumorigenesis; hence, they are used as a diagnostic marker in tumor pathology. In recent years, studies have provided evidence that keratins should be considered not only as markers but also as regulators of cancer cell signaling. The loss of K8/18 expression during epithelial-mesenchymal transition (EMT) is associated with metastasis and chemoresistance. In the present study, we investigated whether K8/18 expression plays an active role in EMT. We show that K8/18 stable knockdown using shRNA increased collective migration and invasiveness of epithelial cancer cells without modulating EMT markers. K8/18-depleted cells showed PI3K/Akt/NF-κB hyperactivation and increased MMP2 and MMP9 expression. K8/18 deletion also increased cisplatin-induced apoptosis. Increased Fas receptor membrane targeting suggests that apoptosis is enhanced via the extrinsic pathway. Interestingly, we identified the tight junction protein claudin1 as a regulator of these processes. This is the first indication that modulation of K8/18 expression can influence the phenotype of epithelial cancer cells at a transcriptional level and supports the hypothesis that keratins play an active role in cancer progression. PMID:23449973

Occurrence and characterization of Campylobacter in the Brazilian production and processing of broilers.

PubMed

Kuana, S L; Santos, L R; Rodrigues, L B; Borsoi, A; Moraes, H L S; Salle, C T P; Nascimento, V P

2008-12-01

Twenty-two commercial broiler flocks and their carcasses, totaling 546 samples (450 collected from a poultry farm and 96 from a slaughterhouse), were surveyed for the presence of Campylobacter. The positive results for Campylobacter among the analyzed samples were homogeneous, yielding 81.8% for cecal droppings, 80.9% for feces, and 80.4% for cloacal swabs. Pre-enrichment and direct plating showed that 77.85% and 81.8% of cloacal swabs, respectively, were positive for Campylobacter compared to 99.0% and 97.9% of carcasses testing positive with the pre-enrichment and direct plating methods. The Campylobacter count averaged 7.0 log10 colony-forming units (CFU)/g in cecal droppings, 5.15 log10 CFU/carcass after defeathering, and 4.24 log10 CFU/carcass after chilling. The samples were identified by the API Campy system as Campylobacter jejuni subsp. jejuni (68.8%), Campylobacter coli (8.3%), Campylobacter jejuni subsp. doylei (6.3%), Campylobacter upsaliensis (4.2%), and Campylobacter fetus subsp. fetus (2.1%). The analyzed broiler flocks were positive for Campylobacter in 81.8% of the cases, thus characterizing the occurrence of this pathogen in a broiler-producing region in southern Brazil. These results highlight the importance of programs targeted at the reduction of Campylobacter in poultry products, in order to minimize the risks for consumers.

Tennessee TCAP Science Scale Scores: Implications for Continuous Improvement and Educational Reform or Is It Possible To Beat the Odds?

ERIC Educational Resources Information Center

Miller-Whitehead, Marie

Evidence provided by analysis of science scale scores on the McGraw-Hill CTB/4 science test for grades 2 through 8 in Tennessee, part of the Tennessee Comprehensive Assessment Program (TCAP), shows that it is possible for high achieving school systems to show continuous improvement from year to year. These results would tend to offset fears that…

Novel optimum contribution selection methods accounting for conflicting objectives in breeding programs for livestock breeds with historical migration.

PubMed

Wang, Yu; Bennewitz, Jörn; Wellmann, Robin

2017-05-12

Optimum contribution selection (OCS) is effective for increasing genetic gain, controlling the rate of inbreeding and enables maintenance of genetic diversity. However, this diversity may be caused by high migrant contributions (MC) in the population due to introgression of genetic material from other breeds, which can threaten the conservation of small local populations. Therefore, breeding objectives should not only focus on increasing genetic gains but also on maintaining genetic originality and diversity of native alleles. This study aimed at investigating whether OCS was improved by including MC and modified kinships that account for breed origin of alleles. Three objective functions were considered for minimizing kinship, minimizing MC and maximizing genetic gain in the offspring generation, and we investigated their effects on German Angler and Vorderwald cattle. In most scenarios, the results were similar for Angler and Vorderwald cattle. A significant positive correlation between MC and estimated breeding values of the selection candidates was observed for both breeds, thus traditional OCS would increase MC. Optimization was performed under the condition that the rate of inbreeding did not exceed 1% and at least 30% of the maximum progress was achieved for all other criteria. Although traditional OCS provided the highest breeding values under restriction of classical kinship, the magnitude of MC in the progeny generation was not controlled. When MC were constrained or minimized, the kinship at native alleles increased compared to the reference scenario. Thus, in addition to constraining MC, constraining kinship at native alleles is required to ensure that native genetic diversity is maintained. When kinship at native alleles was constrained, the classical kinship was automatically lowered in most cases and more sires were selected. However, the average breeding value in the next generation was also lower than that obtained with traditional OCS. For local breeds with historical introgressions, current breeding programs should focus on increasing genetic gain and controlling inbreeding, as well as maintaining the genetic originality of the breeds and the diversity of native alleles via the inclusion of MC and kinship at native alleles in the OCS process.

Differences in physical characteristics and response to rehabilitation for patients with hand dystonia: musicians' cramp compared to writers' cramp.

PubMed

McKenzie, Alison L; Goldman, Sarah; Barrango, Cindy; Shrime, Maria; Wong, Tricia; Byl, Nancy

2009-01-01

Pre-Post, Mixed Factorial Trial. Focal hand dystonia is a challenging movement disorder to rehabilitate in musicians and writers. To compare the neuromusculoskeletal characteristics of those with writers' cramp (WC) and musicians' cramp (MC), and evaluate responsiveness to learning-based sensorimotor training. Twenty-seven individuals (14 musicians, 13 writers) participated in 8 weeks of supervised therapy supplemented with a home program. Between-group differences on measures of musculoskeletal (physical), sensory, and motor performance were evaluated at baseline and post-intervention. Subjects with MC had a higher level of functional independence and better range of motion, but less strength in the affected upper limb than those of subjects with WC. Subjects with MC demonstrated greater accuracy on graphesthesia, kinesthesia, and localization at baseline. No between-group differences in motor performance were noted at baseline or post-intervention. Following individually adapted learning-based sensorimotor training, both groups improved in musculoskeletal (physical) parameters, sensory processing, and motor control; however, improvements on certain subtests differed by group. At follow-up, differences in posture, ROM, strength, graphesthesia, and kinesthesia persisted between the groups. Subjects with WC have different physical and performance risk factors compared with those of subjects with MC. Intervention paradigms are efficacious, but variable responses to rehabilitation occur.

A Tracking Assessment Study of Adult Educational Needs in Atlantic and Cape May Counties, New Jersey: A Prototype Application of the Scipione-McDaniel Paradigm. AIR Forum 1980 Paper.

ERIC Educational Resources Information Center

McDaniel, Walter A.; Scipione, Paul A.

Atlantic Community College (New Jersey) undertook to track the educational needs of adult students in its region. There were three purposes: (1) to improve and expand existing educational programs and services; (2) to gear potential new programs and services to specific community educational needs; and (3) to base all institutional plans on an…

75 FR 57251 - Notice of Request for a Revision of a Currently Approved Information Collection

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-20

...), Food for Progress, and the McGovern-Dole International Food for Education and Child Nutrition programs... (Section 416(b), Food for Progress, and McGovern-Dole International Food for Education and Child Nutrition... Progress, and McGovern-Dole International Food for Education and Child Nutrition programs (the Foreign...

34 CFR 300.818 - Part C of the Act inapplicable.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 2 2011-07-01 2010-07-01 true Part C of the Act inapplicable. 300.818 Section 300.818 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF...

34 CFR 300.818 - Part C of the Act inapplicable.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Part C of the Act inapplicable. 300.818 Section 300.818 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF...

Education for Homeless Children and Youths Program. Title VII-B of the McKinney-Vento Homeless Assistance Act, as Amended by the Every Student Succeeds Act. Non-Regulatory Guidance. Updated

ERIC Educational Resources Information Center

US Department of Education, 2017

2017-01-01

The McKinney-Vento Act was originally authorized in 1987 and originally sponsored programs to provide services to the homeless. The McKinney-Vento Act is designed to address the challenges that homeless children and youths have faced in enrolling, attending, and succeeding in school. Under the McKinney-Vento Act, State educational agencies (SEAs)…

McGill's Integrated Civil and Common Law Program.

ERIC Educational Resources Information Center

Morissette, Yves-Marie

2002-01-01

Describes the bijural program of McGill University Faculty of Law. The program educates all first-degree law students in both the common law and civil law traditions, preparing them for the increasing globalization of legal practice. (EV)

Cyanotoxin occurrence associated with cyanoHAB events on ...

EPA Pesticide Factsheets

A monitoring approach combining wet chemistry and high frequency (HF) water quality sensors was employed to improve our understanding of the ecology of an inland reservoir with a history of cyanoHAB events. The study was conducted with samples collected from Lake Harsha, is a multi-use reservoir in southwest OH that has experienced an increase in cyanoHAB frequency and intensity. Nutrient, algal taxa, chlorophyll-a, and physico-chemical data have been collected on the lake since 2010 at three week intervals. Beginning in 2014 in cooperation with Clermont County Drinking Water Division, a high frequency (HF) monitoring program was implemented to complement the tri-weekly data and provide DWTP operators time-relevant information regarding source water quality. HF data included in-vivo fluorescence and physico-chemical parameters and were collected at two locations. These data, coupled with microcystin (MC) analyses demonstrated the utility of HF data for tracking the cyanoHAB status of the reservoir. It was also apparent that MC concentrations were potentially underestimated as MC sampling did not coincide with bloom peaks indicated by the HF data. To better characterize the cyanobacterial population and both intracellular and extracellular MC production, an intensive sampling regime was implemented in 2015 and 2016 including LC-MSMS analysis of select MC congeners and a total MC surrogate, cylindrospermopsin, and anatoxin-a, MC ELISA quantification, molecular (i.

MrBayes tgMC3++: A High Performance and Resource-Efficient GPU-Oriented Phylogenetic Analysis Method.

PubMed

Ling, Cheng; Hamada, Tsuyoshi; Gao, Jingyang; Zhao, Guoguang; Sun, Donghong; Shi, Weifeng

2016-01-01

MrBayes is a widespread phylogenetic inference tool harnessing empirical evolutionary models and Bayesian statistics. However, the computational cost on the likelihood estimation is very expensive, resulting in undesirably long execution time. Although a number of multi-threaded optimizations have been proposed to speed up MrBayes, there are bottlenecks that severely limit the GPU thread-level parallelism of likelihood estimations. This study proposes a high performance and resource-efficient method for GPU-oriented parallelization of likelihood estimations. Instead of having to rely on empirical programming, the proposed novel decomposition storage model implements high performance data transfers implicitly. In terms of performance improvement, a speedup factor of up to 178 can be achieved on the analysis of simulated datasets by four Tesla K40 cards. In comparison to the other publicly available GPU-oriented MrBayes, the tgMC 3 ++ method (proposed herein) outperforms the tgMC 3 (v1.0), nMC 3 (v2.1.1) and oMC 3 (v1.00) methods by speedup factors of up to 1.6, 1.9 and 2.9, respectively. Moreover, tgMC 3 ++ supports more evolutionary models and gamma categories, which previous GPU-oriented methods fail to take into analysis.

Set up for Success: An Examination of the Ronald E. McNair Postbaccalaureate Achievement Program's Mentoring Component

ERIC Educational Resources Information Center

Wyre, Dwuena Cene

2011-01-01

Often, individuals are set up to fail. However, effective mentoring can set individuals up to succeed. This nonexperimental cross-sectional, predictive study examines the Ronald E. McNair Postbaccalaureate Achievement Program's mentoring component. Specific focus is placed on faculty mentor competency and its impact on McNair student intent to…

Pilot Fullerton examines SE-81-8 Insect Flight Motion Study

NASA Technical Reports Server (NTRS)

1982-01-01

Pilot Fullerton examines Student Experiment 81-8 (SE-81-8) Insect Flight Motion Study taped to the airlock on aft middeck. Todd Nelson, a high school senior from Minnesota, won a national contest to fly his experiment on this particular flight. Moths, flies, and bees were studied in the near weightless environment.

25 CFR 166.818 - How are the proceeds from trespass distributed?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false How are the proceeds from trespass distributed? 166.818... PERMITS Trespass Penalties, Damages, and Costs § 166.818 How are the proceeds from trespass distributed... the trespass occurred. (b) Proceeds recovered under § 166.812 of this subpart may be distributed to...

25 CFR 166.818 - How are the proceeds from trespass distributed?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 1 2013-04-01 2013-04-01 false How are the proceeds from trespass distributed? 166.818... PERMITS Trespass Penalties, Damages, and Costs § 166.818 How are the proceeds from trespass distributed... the trespass occurred. (b) Proceeds recovered under § 166.812 of this subpart may be distributed to...

25 CFR 166.818 - How are the proceeds from trespass distributed?

Code of Federal Regulations, 2012 CFR

2012-04-01

... 25 Indians 1 2012-04-01 2011-04-01 true How are the proceeds from trespass distributed? 166.818... PERMITS Trespass Penalties, Damages, and Costs § 166.818 How are the proceeds from trespass distributed... the trespass occurred. (b) Proceeds recovered under § 166.812 of this subpart may be distributed to...

25 CFR 166.818 - How are the proceeds from trespass distributed?

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 1 2014-04-01 2014-04-01 false How are the proceeds from trespass distributed? 166.818... PERMITS Trespass Penalties, Damages, and Costs § 166.818 How are the proceeds from trespass distributed... the trespass occurred. (b) Proceeds recovered under § 166.812 of this subpart may be distributed to...

25 CFR 166.818 - How are the proceeds from trespass distributed?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 25 Indians 1 2011-04-01 2011-04-01 false How are the proceeds from trespass distributed? 166.818... PERMITS Trespass Penalties, Damages, and Costs § 166.818 How are the proceeds from trespass distributed... the trespass occurred. (b) Proceeds recovered under § 166.812 of this subpart may be distributed to...

49 CFR 178.818 - Tear test.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 3 2013-10-01 2013-10-01 false Tear test. 178.818 Section 178.818 Transportation... Tear test. (a) General. The tear test must be conducted for the qualification of all flexible IBC design types. (b) Special preparation for the tear test. The flexible IBC must be filled to not less than...

ARINC 818 specification revisions enable new avionics architectures

NASA Astrophysics Data System (ADS)

Grunwald, Paul

2014-06-01

The ARINC 818 Avionics Digital Video Bus is the standard for cockpit video that has gained wide acceptance in both the commercial and military cockpits. The Boeing 787, A350XWB, A400M, KC-46A, and many other aircraft use it. The ARINC 818 specification, which was initially release in 2006, has recently undergone a major update to address new avionics architectures and capabilities. Over the seven years since its release, projects have gone beyond the specification due to the complexity of new architectures and desired capabilities, such as video switching, bi-directional communication, data-only paths, and camera and sensor control provisions. The ARINC 818 specification was revised in 2013, and ARINC 818-2 was approved in November 2013. The revisions to the ARINC 818-2 specification enable switching, stereo and 3-D provisions, color sequential implementations, regions of interest, bi-directional communication, higher link rates, data-only transmission, and synchronization signals. This paper discusses each of the new capabilities and the impact on avionics and display architectures, especially when integrating large area displays, stereoscopic displays, multiple displays, and systems that include a large number of sensors.

The Midlatitude Continental Convective Clouds Experiment (MC3E)

DOE PAGES

Jensen, M. P.; Petersen, W. A.; Bansemer, A.; ...

2015-12-18

The Midlatitude Continental Convective Clouds Experiment (MC3E), a field program jointly led by the U.S. Department of Energy’s Atmospheric Radiation Measurement program and the NASA Global Precipitation Measurement (GPM) Mission, was conducted in south-central Oklahoma during April – May 2011. MC3E science objectives were motivated by the need to improve understanding of midlatitude continental convective cloud system lifecycles, microphysics, and GPM precipitation retrieval algorithms. To achieve these objectives a multi-scale surface- and aircraft-based in situ and remote sensing observing strategy was employed. A variety of cloud and precipitation events were sampled during the MC3E, of which results from three deepmore » convective events are highlighted. Vertical structure, air motions, precipitation drop-size distributions and ice properties were retrieved from multi-wavelength radar, profiler, and aircraft observations for an MCS on 11 May. Aircraft observations for another MCS observed on 20 May were used to test agreement between observed radar reflectivities and those calculated with forward-modeled reflectivity and microwave brightness temperatures using in situ particle size distributions and ice water content. Multi-platform observations of a supercell that occurred on 23 May allowed for an integrated analysis of kinematic and microphysical interactions. A core updraft of 25 ms -1 supported growth of hail and large rain drops. As a result, data collected during the MC3E campaign is being used in a number of current and ongoing research projects and is available through the DOE ARM and NASA data archives.« less

The Midlatitude Continental Convective Clouds Experiment (MC3E)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jensen, M. P.; Petersen, W. A.; Bansemer, A.

The Midlatitude Continental Convective Clouds Experiment (MC3E), a field program jointly led by the U.S. Department of Energy’s Atmospheric Radiation Measurement program and the NASA Global Precipitation Measurement (GPM) Mission, was conducted in south-central Oklahoma during April – May 2011. MC3E science objectives were motivated by the need to improve understanding of midlatitude continental convective cloud system lifecycles, microphysics, and GPM precipitation retrieval algorithms. To achieve these objectives a multi-scale surface- and aircraft-based in situ and remote sensing observing strategy was employed. A variety of cloud and precipitation events were sampled during the MC3E, of which results from three deepmore » convective events are highlighted. Vertical structure, air motions, precipitation drop-size distributions and ice properties were retrieved from multi-wavelength radar, profiler, and aircraft observations for an MCS on 11 May. Aircraft observations for another MCS observed on 20 May were used to test agreement between observed radar reflectivities and those calculated with forward-modeled reflectivity and microwave brightness temperatures using in situ particle size distributions and ice water content. Multi-platform observations of a supercell that occurred on 23 May allowed for an integrated analysis of kinematic and microphysical interactions. A core updraft of 25 ms -1 supported growth of hail and large rain drops. As a result, data collected during the MC3E campaign is being used in a number of current and ongoing research projects and is available through the DOE ARM and NASA data archives.« less

Determinants of fertility in Rwanda in the context of a fertility transition: a secondary analysis of the 2010 Demographic and Health Survey.

PubMed

Ndahindwa, Vedaste; Kamanzi, Collins; Semakula, Muhammed; Abalikumwe, François; Hedt-Gauthier, Bethany; Thomson, Dana R

2014-12-13

Major improvements to Rwanda's health system, infrastructure, and social programs over the last decade have led to a rapid fertility transition unique from other African countries. The total fertility rate fell from 6.1 in 2005 to 4.6 in 2010, with a 3-fold increase in contraceptive usage. Despite this rapid national decline, many women still have large numbers of children. This study investigates predictors of fertility during this fertility transition to inform policies that improve individuals' reproductive health and guide national development. We used Poisson regression to separately model number of children born to ever married/cohabitated women (n = 8,309) and never married women (n = 1,220) age 15 to 49 based on 2010 Rwanda Demographic and Health Survey data. We used backward stepwise regression with a time offset to identify individual and household factors associated with woman's fertility level, accounting for sampling weights, clustering, and stratification. In ever married/cohabitating women, high fertility was significantly associated (p < 0.05) with the following variables: unmet need for contraception (IRR = 1.07), women's desire for children (5+ versus 0-2 children: IRR = 1.22), woman's number of siblings (8-20 versus 0-4: IRR = 1.03), and couples who desired different numbers of children (husband wants more: IRR = 1.04; husband wants fewer: IRR = 1.04). Low fertility in ever married/cohabitating women was associated with women's education (higher versus no education: IRR = 0.66), household wealth (highest versus lowest quintile: IRR = 0.93), and delayed sexual debut (25+ versus 8-18 years: IRR = 0.49). In never married women, low fertility was associated with education (higher versus no education: IRR = 0.22), household wealth (highest versus lowest quintile: IRR = 0.58), delayed sexual debut (25-49 versus 8-18 years: IRR = 0.43), and having an unmet need for contraception (IRR = 0.69). Although the study design does not allow causal conclusions, these results suggest several strategies to further reduce Rwanda's national fertility rate and support families to achieve their desired fertility. Strategies include policies and programs that promote delayed sexual debut via educational and economic opportunities for women, improved access to reproductive health information and services at schools and via health campaigns, and involvement of men in family planning decision making.

ARINC 818 adds capabilities for high-speed sensors and systems

NASA Astrophysics Data System (ADS)

Keller, Tim; Grunwald, Paul

2014-06-01

ARINC 818, titled Avionics Digital Video Bus (ADVB), is the standard for cockpit video that has gained wide acceptance in both the commercial and military cockpits including the Boeing 787, the A350XWB, the A400M, the KC- 46A and many others. Initially conceived of for cockpit displays, ARINC 818 is now propagating into high-speed sensors, such as infrared and optical cameras due to its high-bandwidth and high reliability. The ARINC 818 specification that was initially release in the 2006 and has recently undergone a major update that will enhance its applicability as a high speed sensor interface. The ARINC 818-2 specification was published in December 2013. The revisions to the specification include: video switching, stereo and 3-D provisions, color sequential implementations, regions of interest, data-only transmissions, multi-channel implementations, bi-directional communication, higher link rates to 32Gbps, synchronization signals, options for high-speed coax interfaces and optical interface details. The additions to the specification are especially appealing for high-bandwidth, multi sensor systems that have issues with throughput bottlenecks and SWaP concerns. ARINC 818 is implemented on either copper or fiber optic high speed physical layers, and allows for time multiplexing multiple sensors onto a single link. This paper discusses each of the new capabilities in the ARINC 818-2 specification and the benefits for ISR and countermeasures implementations, several examples are provided.

Cytokine expression in three chicken host systems infected with H9N2 influenza viruses with different pathogenicities.

PubMed

Wang, Jianlin; Cao, Zhiwei; Guo, Xuejin; Zhang, Yi; Wang, Dongdong; Xu, Shouzheng; Yin, Yanbo

2016-12-01

SD/818 and SD/196 are H9N2 influenza virus strains isolated from chickens from the same farm at different times that exhibited similar genetic evolution. However, strain SD/818 exhibited higher pathogenicity in chickens than strain SD/196 and other H9N2 influenza virus epidemic strains from China. The expression of cytokines is an important host defence mechanism following viral infection and their intensity is a major determinant of viral pathogenicity. To elucidate the mechanism underlying the increased pathogenicity of strain SD/818 from the host's perspective, viral replication and cytokine expression were dynamically studied using real-time quantitative reverse transcription PCR in chickens infected with strain SD/818 compared with chickens infected with strain SD/196 in this study. The results showed that the replication of strain SD/818 and the expressions of IL-1β, IL-6, TNF-α, IFN-α and IFN-β induced by strain SD/818 were higher than those induced by strain SD/196 in the chicken host system. Expression of these cytokines in chickens coincided with or followed virus replication. These results suggested that high-level viral replication and pro-inflammatory cytokine expression (but not decreased type I IFN expression) were associated with the higher pathogenicity of strain SD/818 in chickens.

20 CFR 408.818 - When does SVB entitlement terminate if your benefit payments have been in suspense for 12...

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false When does SVB entitlement terminate if your benefit payments have been in suspense for 12 consecutive months? 408.818 Section 408.818 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II VETERANS Suspensions and...

20 CFR 408.818 - When does SVB entitlement terminate if your benefit payments have been in suspense for 12...

Code of Federal Regulations, 2011 CFR

2011-04-01

... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false When does SVB entitlement terminate if your benefit payments have been in suspense for 12 consecutive months? 408.818 Section 408.818 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II VETERANS Suspensions and...

20 CFR 408.818 - When does SVB entitlement terminate if your benefit payments have been in suspense for 12...

Code of Federal Regulations, 2012 CFR

2012-04-01

... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false When does SVB entitlement terminate if your benefit payments have been in suspense for 12 consecutive months? 408.818 Section 408.818 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II VETERANS Suspensions and...

20 CFR 408.818 - When does SVB entitlement terminate if your benefit payments have been in suspense for 12...

Code of Federal Regulations, 2014 CFR

2014-04-01

... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false When does SVB entitlement terminate if your benefit payments have been in suspense for 12 consecutive months? 408.818 Section 408.818 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II VETERANS Suspensions and...

Opening the black box: the impact of an oncology management program consisting of level I pathways and an outbound nurse call system.

PubMed

Hoverman, J Russell; Klein, Ira; Harrison, Debra W; Hayes, Jad E; Garey, Jody S; Harrell, Robyn; Sipala, Maria; Houldin, Scott; Jameson, Melissa D; Abdullahpour, Mitra; McQueen, Jessica; Nelson, Greg; Verrilli, Diana K; Neubauer, Marcus

2014-01-01

The Innovent Oncology Program aims to improve the value of cancer care delivered to patients. McKesson Specialty Health and Texas Oncology (TXO) collaborated with Aetna to launch a pilot program. The study objectives were to evaluate the impact of Innovent on Level I Pathway compliance, implement the Patient Support Services program, and measure the rate and costs associated with chemotherapy-related emergency room (ER) visits and hospital admissions. This was a prospective, nonrandomized evaluation of patients enrolled in Innovent from June 1, 2010, through May 31, 2012. Data from the iKnowMed electronic health record, the McKesson Specialty Health financial data warehouse, and Aetna claims data warehouse were analyzed. A total of 221 patients were included and stratified according to disease and age groups; 76% of ordered regimens were on pathway; 24% were off pathway. Pathway adherence improved from TXO baseline adherence of 63%. Of the 221 patients, 81% enrolled in PSS. Within the breast, colorectal, and lung cancer groups, 14% and 24% of patients had an ER visit and in-patient admission (IPA; baseline) versus 10% and 18% in Innovent, respectively; average in-patient days decreased from 2.1 to 1.2 days, respectively. Total savings combined for the program was $506,481. Implementation of Innovent positively affected patient care in several ways: Fewer ER visits and IPAs occurred, in-patient days decreased, cancer-related use costs were reduced, and on-pathway adherence increased.

Improving Decision Making for Advanced Heart Failure Patients and Caregivers.

PubMed

McIlvennan, Colleen K

2017-04-01

In this month's Magnet® Perspectives column, Colleen K. McIlvennan, DNP, ANP, lead nurse practitioner, Advanced Heart Failure and Transplantation at the University of Colorado, discusses her groundbreaking research encompassing patients' and caregivers' emotional, rational, and fundamental beliefs when considering a left ventricular assist device (LVAD). Results have led to the development of 2 innovative decision aids that are currently in use by LVAD programs across the United States and Canada. Dr McIlvennan's efforts led to a $2 million grant from the Patient-Centered Outcomes Research Institute, as well as national recognition from the American Heart Association and the Heart Failure Society of America. Last year, she received the 2016 National Magnet Nurse of the Year® Award in the Empirical Outcomes category. In addition to sharing her findings, Dr McIlvennan examines the value of performing research in a Magnet-recognized organization.

24 CFR 576.1 - Applicability and purpose.

Code of Federal Regulations, 2010 CFR

2010-04-01

... URBAN DEVELOPMENT COMMUNITY FACILITIES EMERGENCY SHELTER GRANTS PROGRAM: STEWART B. McKINNEY HOMELESS... program contained in subtitle B of title IV of the Stewart B. McKinney Homeless Assistance Act (42 U.S.C...

Studies on the antidiabetic activities of Momordica charantia fruit juice in streptozotocin-induced diabetic rats.

PubMed

Mahmoud, Mona F; El Ashry, Fatma El Zahraa Z; El Maraghy, Nabila N; Fahmy, Ahmed

2017-12-01

Momordica charantia Linn (Cucurbitaceae) (MC) is used in folk medicine to treat various diseases including diabetes mellitus. This study investigates the antidiabetic activities of Momordica charantia (bitter gourd) on streptozotocin-induced type 2 diabetes mellitus in rats. Male Wister rats were randomly assigned to 4 groups. Group I, Normal control; Group II, STZ diabetic; Group III and IV, Momordica charantia fruit juice was orally administered to diabetic rats (10 mL/kg/day either as prophylaxis for 14 days before induction of diabetes then 21 days treatment, or as treatment given for 21 days after induction of diabetes). The effects of MC juice were studied both in vivo and in vitro by studying the glucose uptake of isolated rat diaphragm muscles in the presence and absence of insulin. Histopathological examination of pancreas was also performed. This study showed that MC caused a significant reduction of serum glucose (135.99 ± 6.27 and 149.79 ± 1.90 vs. 253.40* ± 8.18) for prophylaxis and treatment respectively, fructosamine (0.99 ± 0.01 and 1.01 ± 0.04 vs. 3.04 ± 0.07), total cholesterol, triglycerides levels, insulin resistance index (1.13 ± 0.08 and 1.19 ± 0.05 vs. 1.48 ± 1.47) and pancreatic malondialdehyde content (p < 0.05). While it induced a significant increase of serum insulin (3.41 ± 0.08 and 3.28 ± 0.08 vs. 2.39 ± 0.27), HDL-cholesterol, total antioxidant capacity levels, β cell function percent, and pancreatic reduced glutathione (GSH) content (p < 0.05) and improved histopathological changes of the pancreas. It also increased glucose uptake by diaphragms of normal (12.17 ± 0.60 vs. 9.07 ± 0.66) and diabetic rats (8.37 ± 0.28 vs. 4.29 ± 0.51) in the absence and presence of insulin (p < 0.05). Momordica charantia presents excellent antidiabetic and antioxidant activities and thus has great potential as a new source for diabetes treatment whether it is used for prophylaxis or treatment.

20 CFR 10.818 - How is a provider notified of OWCP's intent to exclude him or her?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false How is a provider notified of OWCP's intent to exclude him or her? 10.818 Section 10.818 Employees' Benefits OFFICE OF WORKERS' COMPENSATION... How is a provider notified of OWCP's intent to exclude him or her? The Regional Director shall...

26 CFR 1.818-4 - Election with respect to life insurance reserves computed on preliminary term basis.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 26 Internal Revenue 8 2011-04-01 2011-04-01 false Election with respect to life insurance reserves... Provisions § 1.818-4 Election with respect to life insurance reserves computed on preliminary term basis. (a) In general. Section 818(c) permits a life insurance company issuing contracts with respect to which...

The Work, the Workplace, and the Work Force of Tomorrow.

ERIC Educational Resources Information Center

Allen, Claudia

1995-01-01

Ann McLaughlin, a former secretary of labor, discusses her views on the future of the workplace. She feels that to solve the impending problem of educational deficits among the work force, employers will begin their own educational programs, improving both employee loyalty and work force mobility. Includes predictions for future growth fields.…

Multispectral Landsat images of Antartica

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lucchitta, B.K.; Bowell, J.A.; Edwards, K.L.

1988-01-01

The U.S. Geological Survey has a program to map Antarctica by using colored, digitally enhanced Landsat multispectral scanner images to increase existing map coverage and to improve upon previously published Landsat maps. This report is a compilation of images and image mosaic that covers four complete and two partial 1:250,000-scale quadrangles of the McMurdo Sound region.

Global Health Values of a Multidirectional Near Peer Training Program in Surgery, Pathology, Anatomy, Research Methodology, and Medical Education for Haitian, Rwandan, and Canadian Medical Students.

PubMed

Elharram, Malik; Dinh, Trish; Lalande, Annie; Ge, Susan; Gao, Sophie; Noël, Geoffroy

As health care delivery increasingly requires providers to cross international borders, medical students at McGill University, Canada, developed a multidirectional exchange program with Haiti and Rwanda. The program integrates surgery, pathology, anatomy, research methodology, and medical education. The aim of the present study was to explore the global health value of this international training program to improve medical education within the environment of developing countries, such as Haiti and Rwanda, while improving sociocultural learning of Canadian students. Students from the University of Kigali, Rwanda and Université Quisqueya, Haiti, participated in a 3-week program at McGill University. The students spanned from the first to sixth year of their respective medical training. The program consisted of anatomy dissections, surgical simulations, clinical pathology shadowing, and interactive sessions in research methodology and medical education. To evaluate the program, a survey was administered to students using a mixed methodology approach. Common benefits pointed out by the participants included personal and professional growth. The exchange improved career development, sense of responsibility toward one's own community, teaching skills, and sociocultural awareness. The participants all agreed that the anatomy dissections improved their knowledge of anatomy and would make them more comfortable teaching the material when the returned to their university. The clinical simulation activities and shadowing experiences allowed them to integrate the different disciplines. However, the students all felt the research component had too little time devoted to it and that the knowledge presented was beyond their educational level. The development of an integrated international program in surgery, pathology, anatomy, research methodology, and medical education provided medical students with an opportunity to learn about differences in health care and medical education between the 3 countries. This exchange demonstrated that a crosscultural near-peer teaching environment can be an effective and sustainable method of medical student-centered development in global health. Copyright © 2017 Icahn School of Medicine at Mount Sinai. Published by Elsevier Inc. All rights reserved.

Community Resources for Career Education: Starring Baltimore's McCormick Plan

ERIC Educational Resources Information Center

Carey, E. Niel; Marshall, Howard E.

1973-01-01

The article develops from a general discussion of the utilization of community resources in career education to a discussion of a particular program--the McCormick Plan in Baltimore--and other Maryland programs. Suggestions drawn from those programs are offered for identifying and using such resources. (AG)

Ada and software management in NASA: Symposium/forum

NASA Technical Reports Server (NTRS)

1989-01-01

The promises of Ada to improve software productivity and quality, and the claims that a transition to Ada would require significant changes in NASA's training programs and ways of doing business were investigated. The study assesses the agency's ongoing and planned Ada activities. A series of industry representatives (Computer Sciences Corporation, General Electric Aerospace, McDonnell Douglas Space Systems Company, TRW, Lockheed, and Boeing) reviewed the recommendations and assessed their impact from the Company's perspective. The potential effects on NASA programs were then discussed.

The Navy Supply Corps Newsletter. Contracting Innovations: Navy Electronic Commerce Online Navy Afloat Purchase Card Program. Volume 62, No. 3.

DTIC Science & Technology

1998-06-01

Mike Lyden John Lantelme Andy Mackel Jesus Malgapo Carol Marcinek Greg Martin Michelle McAtee Molly McClellan Jerry McEnerney Laurie McKee...Paul McNeill Walt Melton Rich Mendez Mike Metts Jon Miller Ron Mosley Jim Naber Craig Nostrant NAVSUP USSNORMANDY(CG60) DDRE NORFOLK NPGS

76 FR 4148 - Notice of Opportunity for Public Comment on Surplus Property Release at Brunswick-Golden Isles...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-24

... at the following address: Atlanta Airports District Office, Attn: Aimee A. McCormick, Program Manager.... FOR FURTHER INFORMATION CONTACT: Aimee McCormick, Program Manager, Atlanta Airports District Office...

Texas-Style Fundraising and Public Relations for the International Year of Astronomy

NASA Astrophysics Data System (ADS)

Preston, S.; Barna, J. W.; Johnson, R.; Geiger, S.; Rimm, N.; Watson, K.; Griffin, J.

2008-11-01

McDonald Observatory will use the International Year of Astronomy (IYA) celebration to strengthen its fundraising for science education and outreach programs. At the same time, McDonald Observatory will be undergoing a logo and branding campaign in order to better unite the work and relationship of the University of Texas Department of Astronomy, McDonald Observatory, and the Observatory's education and outreach programs.

Jeopardizing a Legacy: A Closer Look at IDEA and Florida's Disability Voucher Program. Special Report.

ERIC Educational Resources Information Center

People for the American Way, Washington, DC.

This report examines the outcomes of the John M. McKay Scholarships Program, a statewide voucher program for students with disabilities in Florida that provides students with taxpayer-funded vouchers to be used at private schools or at other public schools. It argues that the McKay voucher program, which started in 1999, is rife with…

Students' Perspectives on a Gap-Funded Program: The Community Scholarship Program of McCracken County, Kentucky

ERIC Educational Resources Information Center

Hlinka, Karen R.; Gericke, Kevin L.; Akin, S. Renea; Stephenson, Lisa G.

2018-01-01

In 2010, McCracken County, Kentucky implemented the Community Scholarship Program (CSP) to provide graduates of high schools in the county an opportunity to receive a tuition-free community college education. Quantitative data was collected throughout the various stages of student progress through the program. As the first cohort of CSP students…

FY17 Status Report on NEAMS Neutronics Activities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, C. H.; Jung, Y. S.; Smith, M. A.

2017-09-30

Under the U.S. DOE NEAMS program, the high-fidelity neutronics code system has been developed to support the multiphysics modeling and simulation capability named SHARP. The neutronics code system includes the high-fidelity neutronics code PROTEUS, the cross section library and preprocessing tools, the multigroup cross section generation code MC2-3, the in-house meshing generation tool, the perturbation and sensitivity analysis code PERSENT, and post-processing tools. The main objectives of the NEAMS neutronics activities in FY17 are to continue development of an advanced nodal solver in PROTEUS for use in nuclear reactor design and analysis projects, implement a simplified sub-channel based thermal-hydraulic (T/H)more » capability into PROTEUS to efficiently compute the thermal feedback, improve the performance of PROTEUS-MOCEX using numerical acceleration and code optimization, improve the cross section generation tools including MC2-3, and continue to perform verification and validation tests for PROTEUS.« less

75 FR 39493 - Notice of Request for Revision of a Currently Approved Information Collection

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-09

... Education and Child Nutrition programs. DATES: Comments on this notice must be received by September 7, 2010... Programs (Section 416(b)), Food for Progress, and McGovern-Dole International Food for Education and Child... Progress, and McGovern-Dole International Food for Education and Child Nutrition programs (the ``Foreign...

Exploration Medical Capability (ExMC) Program

NASA Technical Reports Server (NTRS)

Kalla, Elizabeth

2006-01-01

This document reviews NASA's Exploration Medical Capability (ExMC) program. The new space exploration program, outlined by the President will present new challenges to the crew's health. The project goals are to develop and validate requirements for reliable, efficient, and robust medical systems and treatments for space exploration to maximize crew performance for mission objectives.

A Collaborative Approach to Family Literacy Evaluation Strategies.

ERIC Educational Resources Information Center

Landerholm, Elizabeth; Karr, Jo Ann; Mushi, Selina

A collaborative approach to program evaluation combined with the use of a variety of evaluation methods using currently available technology can yield valuable information about the effectiveness of family literacy programs. Such an approach was used for McCosh Even Start, a federally-funded family literacy program located at McCosh School in an…

Radial Velocity Detection of Extra-Solar Planetary Systems

NASA Technical Reports Server (NTRS)

Cochran, William D.

2004-01-01

This NASA Origins Program grant supported four closely related research programs at The University of Texas at Austin: 1) The McDonald Observatory Planetary Search (MOPS) Program, using the McDonald Observatory 2.7m Harlan Smith telescope and its 2dcoude spectrometer, 2) A high-precision radial-velocity survey of Hyades dwarfs, using the Keck telescope and its HIRES spectrograph, 3) A program at McDonald Observatory to obtain spectra of the parent stars of planetary systems at R = 210,000, and 4) the start of high precision radial velocity surveys using the Hobby-Eberly Telescope. The most important results from NASA support of these research programs are described. A list of all papers published under support of this grant is included at the end.

76 FR 51120 - Notice of Opportunity for Public Comment on Release of Federally Obligated Property at Hartsfield...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-17

... Airports District Office, Attn: Aimee A. McCormick, Program Manager, 1701 Columbia Ave., Campus Building..., GA 30320-2509. FOR FURTHER INFORMATION CONTACT: Aimee McCormick, Program Manager, Atlanta Airports...

USGS research on energy resources, 1986; program and abstracts

USGS Publications Warehouse

Carter, Lorna M.H.

1986-01-01

The extended abstracts in this volume are summaries of the papers presented orally and as posters in the second V. E. McKelvey Forum on Mineral and Energy Resources, entitled "USGS Research on Energy Resources-1986." The Forum has been established to improve communication between the USGS and the earth science community by presenting the results of current USGS research on nonrenewable resources in a timely fashion and by providing an opportunity for individuals from other organizations to meet informally with USGS scientists and managers. It is our hope that the McKelvey Forum will help to make USGS programs more responsive to the needs of the earth science community, particularly the mining and petroleum industries, and Win foster closer cooperation between organizations and individuals. The Forum was named after former Director Vincent E. McKelvey in recognition of his lifelong contributions to research, development, and administration in mineral and energy resources, as a scientist, as Chief Geologist, and as Director of the U.S. Geological Survey. The Forum will be an annual event, and its subject matter will alternate between mineral and energy resources. We expect that the format will change somewhat from year to year as various approaches are tried, but its primary purpose will remain the same: to encourage direct communication between USGS scientists and the representatives of other earth-science related organizations. Energy programs of the USGS include oil and gas, coal, geothermal, uranium-thorium, and oil shale; work in these programs spans the national domain, including surveys of the offshore Exclusive Economic Zone. The topics selected for presentation at this McKelvey Forum represent an overview of the scientific breadth of USGS research on energy resources. They include aspects of petroleum occurrence in Eastern United States rift basins, the origin of magnetic anomalies over oil fields, accreted terranes and energy-resource implications, coal quality, geothermal energy sources, integrated geology and chemistry in uranium-deposit studies, and interpretations of sea-floor geology seen in reconnaissance-scale sidescan-sonar mosaics of the Gulf of Mexico and west coast Exclusive Economic Zone. Data are presented that are being used in building models of geothermal energy settings, basin histories, and the occurrence of energy resources. In addition to the technical sessions presenting the results of USGS research, each congressionally mandated USGS Mineral Resource Program has a display outlining plans and progress. We are all excited about this continuing opportunity to disseminate and discuss our research with our colleagues in industry and academia, and we welcome your suggestions on improving this series of Forums.

Pilot Fullerton examines SE-81-8 Insect Flight Motion Study

NASA Image and Video Library

1982-03-30

STS003-23-178 (22-30 March 1982) --- Astronaut C. Gordon Fullerton, STS-3 pilot, examines Student Experiment 81-8 (SE-81-8) Insect Flight Motion Study taped to the airlock on aft middeck. Todd Nelson, a high school senior from Minnesota, won a national contest to fly his experiment on this particular flight. Moths, flies, and bees were studied in the near weightless environment. Photo credit: NASA

78 FR 70958 - 30-Day Notice of Proposed Information Collection: Recordkeeping for HUD's Continuum of Care Program

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-27

... Foreclosures and Enhance became Public Law 111-22; Division B of this law is the HEARTH Act. As amended by the HEARTH Act, Subpart C of the McKinney-Vento Homeless Assistance Act establishes the Continuum of Care... et seq.). The HEARTH Act was designed to improve administrative efficiency and enhance response...

Child Development Curriculum Improvement. Course Materials for Selected Courses in a Two-Year Vocational Program in Child Development.

ERIC Educational Resources Information Center

Schlueter, Jane A.; Davis, Cyndie M.

This curriculum guide contains course materials for the seven courses of the child development curriculum at McLennan Community College (Waco, Texas). The courses, which provide information on children from birth through school age, were completely revised in 1986-1987. Course titles are Introduction to Child Development, Growth and Development I…

McNary Dam, Ice Harbor Dam, and Lower Monumental Dam Smolt Monitoring Program; 1996 Annual Report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hillson, Todd; Lind, Sharon; Price, William

1997-07-01

The Washington Department of Fish & Wildlife (WDFW) assumed responsibility for the Smolt Monitoring Program at McNary Dam on the Columbia River in 1990 and at the new juvenile collection facility at Lower Monumental Dam on the Snake River in 1993. In 1996, Smolt Monitoring Program activities also began at the new juvenile collection facility located at Ice Harbor Dam. This report summarizes the 1996 Smolt Monitoring work at all three sites. The work at Ice Harbor consisted of Gas Bubble Trauma (GBT) monitoring only. In general, the 1996 passage season at both the McNary and Lower Monumental sites canmore » be characterized by reduced passage of juveniles through the collection systems due to elevated river flows and spill, and low (<1%) overall facility mortality rates most likely resulting from cooler water temperatures. In accordance with the National Marine Fisheries Service recommendations (NMFS, 1995) all spring migrants were bypassed at McNary Dam in 1996. Mechanical problems within the McNary collection system resulted in collection and sampling activities being delayed until April 18 at this site, while sampling and collection began on the scheduled starting date of April 1 at Lower Monumental Dam. Monitoring operations were conducted through December 14 at McNary Dam and through October 28 at Lower Monumental Dam. An ongoing transportation evaluation summer migrant marking program was conducted at McNary Dam in 1996 by the NMFS. This necessitated the sampling of 394,211 additional fish beyond the recommended sampling guidelines. All total, 509,237 and 31,219 juvenile salmonids were anesthetized and individually counted, examined for scale loss, injuries, and brands by WDFW Smolt Monitoring personnel in 1996 at McNary Dam and Lower Monumental Dam, respectively.« less

78 FR 9771 - Notice of Opportunity for Public Comment on Surplus Property Release at Brunswick-Golden Isles...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-11

... address: Atlanta Airports District Office, Attn: Aimee A. McCormick, Program Manager, 1701 Columbia Ave... McCormick, Program Manager, Atlanta Airports District Office, 1701 Columbia Ave., Suite 2-260, Atlanta, GA...

Do Early Childhood Programs Have Lasting Effects on Children? Evaluation Science Brief

ERIC Educational Resources Information Center

National Forum on Early Childhood Program Evaluation, 2008

2008-01-01

"Evaluation Science Briefs" summarize the findings and implications of a recent study evaluating the effects of an early childhood program or environment. This Brief evaluates the study "Early Intervention in Low Birthweight Premature Infants: Results at 18 Years of Age for the Infant Health and Development Program (IHDP)" (M.C. McCormick, J.…

Parallelization of a Monte Carlo particle transport simulation code

NASA Astrophysics Data System (ADS)

Hadjidoukas, P.; Bousis, C.; Emfietzoglou, D.

2010-05-01

We have developed a high performance version of the Monte Carlo particle transport simulation code MC4. The original application code, developed in Visual Basic for Applications (VBA) for Microsoft Excel, was first rewritten in the C programming language for improving code portability. Several pseudo-random number generators have been also integrated and studied. The new MC4 version was then parallelized for shared and distributed-memory multiprocessor systems using the Message Passing Interface. Two parallel pseudo-random number generator libraries (SPRNG and DCMT) have been seamlessly integrated. The performance speedup of parallel MC4 has been studied on a variety of parallel computing architectures including an Intel Xeon server with 4 dual-core processors, a Sun cluster consisting of 16 nodes of 2 dual-core AMD Opteron processors and a 200 dual-processor HP cluster. For large problem size, which is limited only by the physical memory of the multiprocessor server, the speedup results are almost linear on all systems. We have validated the parallel implementation against the serial VBA and C implementations using the same random number generator. Our experimental results on the transport and energy loss of electrons in a water medium show that the serial and parallel codes are equivalent in accuracy. The present improvements allow for studying of higher particle energies with the use of more accurate physical models, and improve statistics as more particles tracks can be simulated in low response time.

X-33 Proposal by McDonnell Douglas - Computer Graphic

NASA Technical Reports Server (NTRS)

1996-01-01

This artist's rendering depicts the McDonnell Douglas X-33 proposal for a technology demonstrator of a Single-Stage-To-Orbit (SSTO) Reusable Launch Vehicle (RLV). McDonnell Douglas submitted a vertical landing configuration design which used liquid oxygen/hydrogen bell engines. NASA considered design submissions from Rockwell, Lockheed Martin, and McDonnell Douglas. NASA selected Lockheed Martin's design on 2 July 1996. NASA's Dryden Flight research Center, Edwards, California, expected to play a key role in the development and flight testing of the X-33. The RLV technology program was a cooperative agreement between NASA and industry. The goal of the RLV technology program was to enable significant reductions in the cost of access to space, and to promote the creation and delivery of new space services and other activities that was to have improved U.S. economic competitiveness. The X-33 was a wedged-shaped subscale technology demonstrator prototype of a potential future Reusable Launch Vehicle (RLV) that Lockheed Martin had dubbed VentureStar. The company had hoped to develop VentureStar early this century. Through demonstration flight and ground research, NASA's X-33 program was to have provided the information needed for industry representatives such as Lockheed Martin to decide whether to proceed with the development of a full-scale, commercial RLV program. A full-scale, single-stage-to-orbit RLV was to have dramatically increased reliability and lowered the costs of putting a pound of payload into space, from the current figure of $10,000 to $1,000. Reducing the cost associated with transporting payloads in Low Earth Orbit (LEO) by using a commercial RLV was to have created new opportunities for space access and significantly improved U.S. economic competitiveness in the world-wide launch marketplace. NASA expected to be a customer, not the operator, of the commercial RLV. The X-33 design was based on a lifting body shape with two revolutionary 'linear aerospike' rocket engines and a rugged metallic thermal protection system. The vehicle also had lightweight components and fuel tanks built to conform to the vehicle's outer shape. Time between X-33 flights was normally to have been seven days, but the program hoped to demonstrate a two-day turnaround between flights during the flight-test phase of the program. The X-33 was to have been an unpiloted vehicle that took off vertically like a rocket and landed horizontally like an airplane. It was to have reached altitudes of up to 50 miles and high hypersonic speeds. The X-33 program was managed by the Marshall Space Flight Center and was to have been launched at a special launch site on Edwards Air Force Base. Due to technical problems with the liquid hydrogen fuel tanks, and the resulting cost increase and time delay, the X-33 program was cancelled in February 2001.

Radial Velocity Detection of Extra-Solar Planetary Systems

NASA Technical Reports Server (NTRS)

Cochran, William D.

2004-01-01

This NASA Origins Program grant supported four closely related research programs at The University of Texas at Austin: 1) The McDonald Observatory Planetary Search (MOPS) Program, using the McDonald Observatory 2.7m Harlan Smith telescope and its 2dcoud6 spectrometer, 2) A high-precision radial-velocity survey of Hyades dwarfs, using the Keck telescope and its HIRES spectrograph, 3) A program at McDonald Observatory to obtain spectra of the parent stars of planetary systems at R = 210,000, and 4) the start of high precision radial velocity surveys using the Hobby-Eberly Telescope. The most important results from NASA support of these research programs are described below. A list of all papers published under support of this grant is included at the end.

The McDonnell Douglas geophysical observatory program progress report 13 Conjugate point riometer program

NASA Technical Reports Server (NTRS)

Baker, M. B.

1975-01-01

This report, the thirteenth and final progress report on the McDonnell Douglas Geophysical Observatory Program, discusses history of the program from 1962 through 1973, and results of the research carried out in 1974. Topic areas covered include: Station operation; Ionospheric work; Solar studies, Magnetospheric studies; Satellite measurements; International participation; and, 1974 research on solar activity, ATS-6 studies, magnetospheric physics, and station operation.

Enhancing Involvement in Treatment Decision Making by Women with Breast Cancer

DTIC Science & Technology

2007-07-01

2003) 1995 MSc (Design, Measurement and Evaluation), McMaster University, Hamilton, Canada 1984 BHSc ( Physiotherapy ) McMaster University...Hamilton, Canada 1978 Diploma in Physiotherapy , Mohawk College, Hamilton, Canada Certificate in Physiotherapy , McMaster University, Hamilton...McMaster Physiotherapy Program, Mohawk College of Applied Arts and Technology, Hamilton, Ontario CLINICAL 1999- Physiotherapist, Hamilton Health

Enhancing Involvement in Treatment Decision Making by Women with Breast Cancer

DTIC Science & Technology

2008-07-01

Evaluation), McMaster University, Hamilton, Canada 1984 BHSc ( Physiotherapy ) McMaster University, Hamilton, Canada 1978 Diploma in Physiotherapy ...Mohawk College, Hamilton, Canada Certificate in Physiotherapy , McMaster University, Hamilton, Canada CURRENT STATUS AT MCMASTER UNIVERSITY 2001...University of York, United Kingdom 1985-1991 Clinical Education Co-ordinator, Mohawk-McMaster Physiotherapy Program, Mohawk College of Applied

CTUIR Grande Ronde River Watershed Restoration Program McCoy Creek/McIntyre Creek Road Crossing, 1995-1999 Progress Report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Childs, Allen B.

2000-08-01

The Confederated Tribes of the Umatilla Indian Reservation (CTUIR) and Bonneville Power Administration (BPA) entered into a contract agreement beginning in 1996 to fund watershed restoration and enhancement actions and contribute to recovery of fish and wildlife resources and water quality in the Grande Ronde River Basin. The CTUIR's habitat program is closely coordinated with the Grande Ronde Model Watershed Program and multiple agencies and organizations within the basin. The CTUIR has focused during the past 4 years in the upper portions of the Grande Ronde Subbasin (upstream of LaGrande, Oregon) on several major project areas in the Meadow, McCoy,more » and McIntyre Creek watersheds and along the mainstem Grande Ronde River. This Annual Report provides an overview of individual projects and accomplishments.« less

Department of Defense In-House RDT&E Activities. Management Analysis Report

DTIC Science & Technology

1988-10-30

Surveying 621 Nurse Assistant Technician 622 Medical Supply Aid 818 Engineering 625 Autopsy Attendant Drafting 636 Rehabilitation Therapy Asst 856...IMPORTANT PROGRAMS AVIATOR PERFORMANCE EFFECTS OF CHEMICAL AGENT ANTIDOTE THERAPIES . INDIVIDUAL AND CREW STRESS/WORKLOAD/PERFORMANCE. BIOMEDICAL HAZARDS...MIL.RELEVANT INFECT.DISEASES IN S.W.ASIA AND AFRICA. THERAPY OF INFECT. DISEASE IN S.W.ASIA AND AFRICA RAPID & EARLY DIAG. OF INFECT.DISEASES OF

North Carolina Toxic Substance Incidents Program 2010-2015: Identifying Areas for Injury Prevention Efforts.

PubMed

Eiffert, Samantha; Etienne, Suze; Hirsch, Annie; Langley, Ricky

2017-08-06

The National Toxic Substance Incidents Program (NTSIP) is a surveillance system designed to capture acute toxic substance releases, factors contributing to the release, and any associated injuries. North Carolina has participated since 2010, when NTSIP was established. This article will present a descriptive statistical summary from 2010 to 2015 focused on releases that resulted in injuries in order to identify areas for public health prevention efforts. Of the 1690 toxic releases in North Carolina, 155 incidents resulted in injuries and 500 people were injured. Carbon monoxide injured the greatest number of people. Of the incidents that resulted in injuries, 68 occurred at private vehicles or residences (44%), injuring 124 people (25%). Over half of events where at least one responder was injured occurred at private vehicles or residences. Events occurring at private residences did not have a significant relationship between evacuations and injuries, while for industry-related events, the odds of an evacuation being ordered were 8.18 times greater (OR = 8.18, 95% CI = 5.19, 12.89) when there were injuries associated with an event. Intervention efforts should focus on preventing responder injuries while responding to private residence releases and educating the general public on how to prevent injuries by self-evacuating areas where hazardous chemicals have been released.

North Carolina Toxic Substance Incidents Program 2010–2015: Identifying Areas for Injury Prevention Efforts

PubMed Central

Eiffert, Samantha; Etienne, Suze; Hirsch, Annie

2017-01-01

The National Toxic Substance Incidents Program (NTSIP) is a surveillance system designed to capture acute toxic substance releases, factors contributing to the release, and any associated injuries. North Carolina has participated since 2010, when NTSIP was established. This article will present a descriptive statistical summary from 2010 to 2015 focused on releases that resulted in injuries in order to identify areas for public health prevention efforts. Of the 1690 toxic releases in North Carolina, 155 incidents resulted in injuries and 500 people were injured. Carbon monoxide injured the greatest number of people. Of the incidents that resulted in injuries, 68 occurred at private vehicles or residences (44%), injuring 124 people (25%). Over half of events where at least one responder was injured occurred at private vehicles or residences. Events occurring at private residences did not have a significant relationship between evacuations and injuries, while for industry-related events, the odds of an evacuation being ordered were 8.18 times greater (OR = 8.18, 95% CI = 5.19, 12.89) when there were injuries associated with an event. Intervention efforts should focus on preventing responder injuries while responding to private residence releases and educating the general public on how to prevent injuries by self-evacuating areas where hazardous chemicals have been released. PMID:29051448

Using Blended Learning as an Innovative Delivery Model for an In-House Language Program

ERIC Educational Resources Information Center

Gadbois, Manon; Quildon, Denise

2013-01-01

This paper reports on the development and implementation in 2012 of McGill University's French at Work program for McGill employees, using a blended learning model. The program is an example of how a reduction in face-to-face teaching presents one solution to employees' scheduling constraints and how this model might offer suggestions for the…

INSTALLATION AT FRANKFURT OF A RECEIVING STATION FOR THE TRANSIT PROGRAM, PHASE I

DTIC Science & Technology

ata. The 2 receivers cover the range between 53 and 262 mc that includes satelite frequencies of 54, 108, 162 and 216 mc, except 324 mc. It wil be...E 390 envisaged for the reception of standard frequencies and time signals, satelites can be observed at a frequency of 20 mc (using a sepaate local

[Correction of local and central disorders in patients with chronic abacterial prostatitis in usage of amus-01-intramag unit].

PubMed

Glybochko, P V; Gol'braĭkh, G E; Raĭgorodskiĭ, Iu M; Valiev, A Z; Surikov, V N

2007-01-01

Combined use of dynamic magnetotherapy of local and central action in combination with antibacterial endourethral therapy and rectal administration of vitaprost arrests symptoms of chronic prostatitis. Combination of local and total dynamic magnetotherapy with application of AMUS-01-INTRAMAG unit improves erection quality in 81.8% males with psychogenic form of erectile dysfunction. There was also improvement of spermogram parameters and relieve of asthenovegetative syndrome.

Characterisation of FAP-1 expression and CD95 mediated apoptosis in the A818-6 pancreatic adenocarcinoma differentiation system.

PubMed

Winterhoff, Boris J N; Arlt, Alexander; Duttmann, Angelika; Ungefroren, Hendrik; Schäfer, Heiner; Kalthoff, Holger; Kruse, Marie-Luise

2012-03-01

The present study investigated the expression and localisation of FAP-1 (Fas associated phosphatase-1) and CD95 in a 3D differentiation model in comparison to 2D monolayers of the pancreatic adenocarcinoma cell line A818-6. Under non-adherent growth conditions, A818-6 cells differentiate into 3D highly organised polarised epithelial hollow spheres, resembling duct-like structures. A818-6 cells showed a differentiation-dependent FAP-1 localisation. Cells grown as 2D monolayers revealed FAP-1 staining in a juxtanuclear cisternal position, as well as localisation in the nucleus. After differentiation into hollow spheres, FAP-1 was relocated towards the actin cytoskeleton beneath the outer plasma membrane of polarised cells and no further nuclear localisation was observed. CD95 surface staining was found only in a subset of A818-6 monolayer cells, while differentiated hollow spheres appeared to express CD95 in all cells of a given sphere. We rarely observed co-localisation of CD95 and FAP-1 in A818-6 monolayer cells, but strong co-localisation beneath the outer plasma membrane in polarised cells. Analysis of surface expression by flow cytometry revealed that only a subset (36%) of monolayer cells showed CD95 surface expression, and after induction of hollow spheres, CD95 presentation at the outer plasma membrane was reduced to 13% of hollow spheres. Induction of apoptosis by stimulation with agonistic anti-CD95 antibodies, resulted in increased caspase activity in both, monolayer cells and hollow spheres. Knock down of FAP-1 mRNA in A818-6 monolayer cells did not alter resposiveness to CD95 agonistic antibodies. These data suggested that CD95 signal transduction was not affected by FAP-1 expression in A818-6 monolayer cells. In differentiated 3D hollow spheres, we found a polarisation-induced co-localisation of CD95 and FAP-1. A tight control of receptor surface representation and signalling induced apoptosis ensures controlled removal of individual cells instead of a "snowball effect" of apoptotic events. Copyright © 2011 International Society of Differentiation. Published by Elsevier B.V. All rights reserved.

Training an Aging Work Force.

ERIC Educational Resources Information Center

Allen, Annamary Zappia

This manual provides information and suggestions on training the increasingly older work force. An introduction addresses a needed emphasis on training programs to retain older workers as employees and development of effective training that focuses on needs and limitations of older adults as learners. It introduces McDonald's McMaster's Program,…

A continued program of planetary study at the University of Texas McDonald Observatory

NASA Technical Reports Server (NTRS)

Trafton, L.

1991-01-01

The program conducts solar system research in support of NASA missions and of general astronomical interest. Investigations of composition, physical characteristics and changes in solar system bodies are conducted primarily using the facilities of McDonald Observatory. Progress, accomplishments, and projected accomplishments are discussed.

Landing Technique Improvements After an Aquatic-Based Neuromuscular Training Program in Physically Active Women.

PubMed

Scarneo, Samantha E; Root, Hayley J; Martinez, Jessica C; Denegar, Craig; Casa, Douglas J; Mazerolle, Stephanie M; Dann, Catie L; Aerni, Giselle A; DiStefano, Lindsay J

2017-01-01

Neuromuscular training programs (NTPs) improve landing technique and decrease vertical ground-reaction forces (VGRFs), resulting in injury-risk reduction. NTPs in an aquatic environment may elicit the same improvements as land-based programs with reduced joint stress. To examine the effects of an aquatic NTP on landing technique as measured by the Landing Error Scoring System (LESS) and VGRFs, immediately and 4 mo after the intervention. Repeated measures, pool and laboratory. Fifteen healthy, recreationally active women (age 21 ± 2 y, mass 62.02 ± 8.18 kg, height 164.74 ± 5.97 cm) who demonstrated poor landing technique (LESS-Real Time > 4). All participants completed an aquatic NTP 3 times/wk for 6 wk. Participants' landing technique was evaluated using a jump-landing task immediately before (PRE), immediately after (POST), and 4 mo after (RET) the intervention period. A single rater, blinded to time point, graded all videos using the LESS, which is a valid and reliable movement-screening tool. Peak VGRFs were measured during the stance phase of the jump-landing test. Repeated-measure analyses of variance with planned comparisons were performed to explore differences between time points. LESS scores were lower at POST (4.46 ± 1.69 errors) and at RET (4.2 ± 1.72 errors) than at PRE (6.30 ± 1.78 errors) (P < .01). No significant differences were observed between POST and RET (P > .05). Participants also landed with significantly lower peak VGRFs (P < .01) from PRE (2.69 ± .72 N) to POST (2.23 ± .66 N). The findings introduce evidence that an aquatic NTP improves landing technique and suggest that improvements are retained over time. These results show promise of using an aquatic NTP when there is a desire to reduce joint loading, such as early stages of rehabilitation, to improve biomechanics and reduce injury risk.

Principles of Precision Prevention Science for Improving Recruitment and Retention of Participants.

PubMed

Supplee, Lauren H; Parekh, Jenita; Johnson, Makedah

2018-03-12

Precision medicine and precision public health focus on identifying and providing the right intervention to the right population at the right time. Expanding on the concept, precision prevention science could allow the field to examine prevention programs to identify ways to make them more efficient and effective at scale, including addressing issues related to engagement and retention of participants. Research to date on engagement and retention has often focused on demographics and risk factors. The current paper proposes using McCurdy and Daro (Family Relations, 50, 113-121, 2001) model that posits a complex mixture of individual, provider, program, and community-level factors synergistically affect enrollment, engagement, and retention. The paper concludes recommending the use of research-practice partnerships and innovative, rapid cycle methods to design and improve prevention programs related to participant engagement and retention at scale.

38 CFR 8.18 - Total disability-speech.

Code of Federal Regulations, 2010 CFR

2010-07-01

... SERVICE LIFE INSURANCE Premium Waivers and Total Disability § 8.18 Total disability—speech. The organic loss of speech shall be deemed to be total disability under National Service Life Insurance. [67 FR...

38 CFR 8.18 - Total disability-speech.

Code of Federal Regulations, 2011 CFR

2011-07-01

... SERVICE LIFE INSURANCE Premium Waivers and Total Disability § 8.18 Total disability—speech. The organic loss of speech shall be deemed to be total disability under National Service Life Insurance. [67 FR...

Tide Gauge Records Reveal Improved Processing of Gravity Recovery and Climate Experiment Time-Variable Mass Solutions over the Coastal Ocean

NASA Astrophysics Data System (ADS)

Piecuch, Christopher G.; Landerer, Felix W.; Ponte, Rui M.

2018-05-01

Monthly ocean bottom pressure solutions from the Gravity Recovery and Climate Experiment (GRACE), derived using surface spherical cap mass concentration (MC) blocks and spherical harmonics (SH) basis functions, are compared to tide gauge (TG) monthly averaged sea level data over 2003-2015 to evaluate improved gravimetric data processing methods near the coast. MC solutions can explain ≳ 42% of the monthly variance in TG time series over broad shelf regions and in semi-enclosed marginal seas. MC solutions also generally explain ˜5-32 % more TG data variance than SH estimates. Applying a coastline resolution improvement algorithm in the GRACE data processing leads to ˜ 31% more variance in TG records explained by the MC solution on average compared to not using this algorithm. Synthetic observations sampled from an ocean general circulation model exhibit similar patterns of correspondence between modeled TG and MC time series and differences between MC and SH time series in terms of their relationship with TG time series, suggesting that observational results here are generally consistent with expectations from ocean dynamics. This work demonstrates the improved quality of recent MC solutions compared to earlier SH estimates over the coastal ocean, and suggests that the MC solutions could be a useful tool for understanding contemporary coastal sea level variability and change.

Measuring the quality of life of people at the end of life: The McGill Quality of Life Questionnaire-Revised.

PubMed

Cohen, S Robin; Sawatzky, Richard; Russell, Lara B; Shahidi, Javad; Heyland, Daren K; Gadermann, Anne M

2017-02-01

The McGill Quality of Life Questionnaire has been widely used with people with life-threatening illnesses without modification since its publication in 1996. With use, areas for improvement have emerged; therefore, various minor modifications were tested over time. To revise the McGill Quality of Life Questionnaire (McGill Quality of Life Questionnaire-Revised) while maintaining or improving its psychometric properties and length, keeping it as close as possible to the McGill Quality of Life Questionnaire to enable reasonable comparison with existing McGill Quality of Life Questionnaire literature. Data sets from eight studies were used (four studies originally used to develop the McGill Quality of Life Questionnaire, two to develop new McGill Quality of Life Questionnaire versions, and two with unrelated purposes). The McGill Quality of Life Questionnaire-Revised was developed using analyses of measurement invariance, confirmatory factor analysis, and calculation of correlations with the McGill Quality of Life Questionnaire's global quality of life item. Data were from 1702 people with life-threatening illnesses recruited from acute and palliative care units, palliative home care services, and oncology and HIV/AIDS outpatient clinics. The McGill Quality of Life Questionnaire-Revised consists of 14 items (plus the global quality of life item). A new Physical subscale was created combining physical symptoms and physical well-being and a new item on physical functioning. The Existential subscale was reduced to four items. The revised Support subscale, renamed Social, focuses more on relationships. The Psychological subscale remains unchanged. Confirmatory factor analysis results provide support for the measurement structure of the McGill Quality of Life Questionnaire-Revised. The overall scale has good internal consistency reliability ( α = 0.94). The McGill Quality of Life Questionnaire-Revised improves on and can replace the McGill Quality of Life Questionnaire since it contains improved wording, a somewhat expanded repertoire of concepts with fewer items, and a single subscale for the physical domain, while retaining good psychometric properties.

Teachers' Voices on Integrating Metacognition into Science Education

NASA Astrophysics Data System (ADS)

Ben-David, Adi; Orion, Nir

2013-12-01

This study is an attempt to gain new insight, on behalf of science teachers, into the integration of metacognition (MC) into science education. Participants were 44 elementary school science teachers attending an in-service teacher-training (INST) program. Data collection was carried out by several data sources: recordings of all verbal discussions that took place during the program, teachers' written reflections, and semi-structured individual interviews. Our study provides a qualitative analysis of the 44 teachers' voices as a group, as well as a detailed case-study narrative analysis of three teachers' stories The findings show that the teachers' intuitive (pre-instructional) thinking was incomplete and unsatisfactory and their voices were skeptical and against the integration of MC. After teachers had mastered the notion of MC in the INST program, the following outcomes have been identified: (a) teachers expressed amazement at how such an important and relevant issue had been almost invisible to them; (b) teachers identified the affective character of metacognitive experiences as the most significant facet of MC, which acts as a mediator between teaching and learning; (c) the complete lack of learning materials addressing MC and the absence of supportive in-classroom guidance were identified as the major obstacles for its implementation; (d) teachers expressed a willingness to continue their professional development toward expanding their abilities to integrate MC as an inseparable component of the science curriculum. The implications of the findings for professional development courses in the field of MC are discussed.

Advanced Tactical Booster Technologies: Applications for Long-Range Rocket Systems

DTIC Science & Technology

2016-09-07

Applications for Long-Range Rocket Systems 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Matthew McKinna, Jason Mossman 5d...technology advantages currently under development for tactical rocket motors which have direct application to land-based long-range rocket systems...increased rocket payload capacity, improved rocket range or increased rocket loadout from the volumetrically constrained environment of a land-based

[Training in iterative hypothesis testing as part of psychiatric education. A randomized study].

PubMed

Lampen-Imkamp, S; Alte, C; Sipos, V; Kordon, A; Hohagen, F; Schweiger, U; Kahl, K G

2012-01-01

The improvement of medical education is at the center of efforts to reform the studies of medicine. Furthermore, an excellent teaching program for students is a quality feature of medical universities. Besides teaching of disease-specific contents, the acquisition of interpersonal and decision-making skills is important. However, the cognitive style of senior physicians leading to a diagnosis cannot easily be taught. Therefore, the following study aimed at examining whether specific training in iterative hypothesis testing (IHT) may improve the correctness of the diagnostic process. Seventy-one medical students in their 9th-11th terms were randomized to medical teaching as usual or to IHT training for 4 weeks. The intervention group received specific training according to the method of IHT. All students were examined by a multiple choice (MC) exam and additionally by simulated patients (SP). The SPs were instructed to represent either a patient with depression and comorbid anxiety and substance use disorder (SP1) or to represent a patient with depression, obsessive-compulsive disorder and acute suicidal tendencies (SP2). All students identified the diagnosis of major depression in the SPs, but IHT-trained students recognized more diagnostic criteria. Furthermore, IHT-trained students recognized acute suicide tendencies in SP2 more often and identified more comorbid psychiatric disorders. The results of the MC exam were comparable in both groups. An analysis of the satisfaction with the different training programs revealed that the IHT training received a better appraisal. Our results point to the role of IHT in teaching diagnostic skills. However, the results of the MC exam were not influenced by IHT training. Furthermore, our results show that students are in need of training in practical clinical skills.

Family medicine residents' practice intentions: Theory of planned behaviour evaluation.

PubMed

Grierson, Lawrence E M; Fowler, Nancy; Kwan, Matthew Y W

2015-11-01

To assess residents' practice intentions since the introduction of the College of Family Physicians of Canada's Triple C curriculum, which focuses on graduating family physicians who will provide comprehensive care within traditional and newer models of family practice. A survey based on Ajzen's theory of planned behaviour was administered on 2 occasions. McMaster University in Hamilton, Ont. Residents (n = 135) who were enrolled in the Department of Family Medicine Postgraduate Residency Program at McMaster University in July 2012 and July 2013; 54 of the 60 first-year residents who completed the survey in 2012 completed it again in 2013. The survey was modeled so as to measure the respondents' intentions to practise with a comprehensive scope; determine the degree to which their attitudes, subjective norms, and perceptions of control about comprehensive practice influence those intentions; and investigate how these relationships change as residents progress through the curriculum. The survey also queried the respondents about their intentions with respect to particular medical services that underpin comprehensive practice. The responses indicate that the factors modeled by the theory of planned behaviour survey account for 60% of the variance in the residents' intentions to adopt a comprehensive scope of practice upon graduation, that there is room for curricular improvement with respect to encouraging residents to practise comprehensive care, and that targeting subjective norms about comprehensive practice might have the greatest influence on improving resident intentions. The theory of planned behaviour presents an effective approach to assessing curricular effects on resident practice intentions while also providing meaningful information for guiding further program evaluation efforts in the Department of Family Medicine at McMaster University.

Family medicine residents’ practice intentions

PubMed Central

Grierson, Lawrence E.M.; Fowler, Nancy; Kwan, Matthew Y.W.

2015-01-01

Abstract Objective To assess residents’ practice intentions since the introduction of the College of Family Physicians of Canada’s Triple C curriculum, which focuses on graduating family physicians who will provide comprehensive care within traditional and newer models of family practice. Design A survey based on Ajzen’s theory of planned behaviour was administered on 2 occasions. Setting McMaster University in Hamilton, Ont. Participants Residents (n = 135) who were enrolled in the Department of Family Medicine Postgraduate Residency Program at McMaster University in July 2012 and July 2013; 54 of the 60 first-year residents who completed the survey in 2012 completed it again in 2013. Main outcome measures The survey was modeled so as to measure the respondents’ intentions to practise with a comprehensive scope; determine the degree to which their attitudes, subjective norms, and perceptions of control about comprehensive practice influence those intentions; and investigate how these relationships change as residents progress through the curriculum. The survey also queried the respondents about their intentions with respect to particular medical services that underpin comprehensive practice. Results The responses indicate that the factors modeled by the theory of planned behaviour survey account for 60% of the variance in the residents’ intentions to adopt a comprehensive scope of practice upon graduation, that there is room for curricular improvement with respect to encouraging residents to practise comprehensive care, and that targeting subjective norms about comprehensive practice might have the greatest influence on improving resident intentions. Conclusion The theory of planned behaviour presents an effective approach to assessing curricular effects on resident practice intentions while also providing meaningful information for guiding further program evaluation efforts in the Department of Family Medicine at McMaster University. PMID:26889508

LFC leading edge glove flight: Aircraft modification design, test article development and systems integration

NASA Technical Reports Server (NTRS)

Etchberger, F. R.

1983-01-01

Reduction of skin friction drag by suction of boundary layer air to maintain laminar flow has been known since Prandtl's published work in 1904. The dramatic increases in fuel costs and the potential for periods of limited fuel availability provided the impetus to explore technologies to reduce transport aircraft fuel consumption. NASA sponsored the Aircraft Energy Efficiency (ACEE) program in 1976 to develop technologies to improve fuel efficiency. This report documents the Lockheed-Georgia Company accomplishments in designing and fabricating a leading-edge flight test article incorporating boundary layer suction slots to be flown by NASA on their modified JetStar aircraft. Lockheed-Georgia Company performed as the integration contractor to design the JetStar aircraft modification to accept both a Lockheed and a McDonnell Douglas flight test article. McDonnell Douglas uses a porous skin concept. The report describes aerodynamic analyses, fabrication techniques, JetStar modifications, instrumentation requirements, and structural analyses and testing for the Lockheed test article. NASA will flight test the two LFC leading-edge test articles in a simulated commercial environment over a 6 to 8 month period in 1984. The objective of the flight test program is to evaluate the effectiveness of LFC leading-edge systems in reducing skin friction drag and consequently improving fuel efficiency.

Hemoglobin A1c (HbA1c) changes over time among adolescent and young adult participants in the T1D exchange clinic registry.

PubMed

Clements, Mark A; Foster, Nicole C; Maahs, David M; Schatz, Desmond A; Olson, Beth A; Tsalikian, Eva; Lee, Joyce M; Burt-Solorzano, Christine M; Tamborlane, William V; Chen, Vincent; Miller, Kellee M; Beck, Roy W

2016-08-01

Hemoglobin A1c (HbA1c) levels among individuals with type 1 diabetes (T1D) influence the longitudinal risk for diabetes-related complications. Few studies have examined HbA1c trends across time in children, adolescents, and young adults with T1D. This study examines changes in glycemic control across the specific transition periods of pre-adolescence-to-adolescence and adolescence-to-young adulthood, and the demographic and clinical factors associated with these changes. Available HbA1c lab results for up to 10 yr were collected from medical records at 67 T1D Exchange clinics. Two retrospective cohorts were evaluated: the pre-adolescent-to-adolescent cohort consisting of 85 016 HbA1c measurements from 6574 participants collected when the participants were 8-18 yr old and the adolescent-to-young adult cohort, 2200 participants who were 16-26 yr old at the time of 17 279 HbA1c measurements. HbA1c in the 8-18 cohort increased over time after age 10 yr until ages 16-17; followed by a plateau. HbA1c levels in the 16-26 cohort remained steady from 16-18, and then gradually declined. For both cohorts, race/ethnicity, income, health insurance, and pump use were all significant in explaining individual variations in age-centered HbA1c (p < 0.001). For the 8-18 cohort, insulin pump use, age of onset, and health insurance were significant in predicting individual HbA1c trajectory. Glycemic control among patients 8-18 yr old worsens over time, through age 16. Elevated HbA1c levels observed in 18 yr-olds begin a steady improvement into early adulthood. Focused interventions to prevent deterioration in glucose control in pre-adolescence, adolescence, and early adulthood are needed. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Beyond McPoetry: Contemporary American Poetry in the Institutionalized Creative Writing Program Era

ERIC Educational Resources Information Center

Porter, Julie LaRue

2012-01-01

This dissertation examines the rise of the creative writing program in American higher education and considers its influence on contemporary American poetry. I investigate how the patronage of the university has impacted American poetry and reconfigured the contemporary literary landscape. Using Mark McGurl's (2009) groundbreaking research on…

Engineers of the Future: The Colorado School of Mines' McBride Honors Program.

ERIC Educational Resources Information Center

Olds, Barbara M.

1988-01-01

More educators argue that science and technology students must be more liberally educated. The McBride Honors Program at Colorado School of Mines addresses the needs of a global society by preparing engineers to be technically competent, with strong communication skills, and knowledge of societal issues. (MLW)

77 FR 27214 - Applications for New Awards; Ronald E. McNair Postbaccalaureate Achievement Program

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-09

... educational support for qualified individuals from disadvantaged backgrounds. The McNair Program is a... provide disadvantaged college students with effective preparation for doctoral study. The President has set a clear goal for our education system: By 2020, the United States will once again lead the world...

Education Program - Teacher in Space

NASA Image and Video Library

1985-12-17

S85-46205 (December 1985) --- Sharon Christa McAuliffe (left), from Concord, New Hampshire, and Barbara R. Morgan of McCall, Idaho, have been named NASA Teacher-in-Space Project prime and backup payload specialists, respectively, for the first citizen observer position of the STS program, scheduled for a Challenger flight in January 1986. Photo credit: NASA

78 FR 6334 - Housing Choice Voucher Program; Office of Public and Indian Housing Announcement of Funding...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-30

... ALLEN HA 2301 JASMINE AVE, MC ALLEN, TX 80 336,384 78501. VA: ALEXANDRIA REDEV & HA 600 N FAIRFAX ST... ANTONIO, TX 0 19,600 78295. TX: MC ALLEN HA 2301 JASMINE AVE, MC ALLEN, TX 0 15,800 78501. VA: ALEXANDRIA...

76 FR 20305 - Notice of Funding Availability: Inviting Applications for McGovern-Dole International Food for...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-12

... DEPARTMENT OF AGRICULTURE Foreign Agricultural Service Notice of Funding Availability: Inviting Applications for McGovern-Dole International Food for Education and Child Nutrition Program's Micronutrient... March 14, 2011, inviting proposals for the McGovern-Dole International Food for Education and Child...

Marketing fast food: impact of fast food restaurants in children's hospitals.

PubMed

Sahud, Hannah B; Binns, Helen J; Meadow, William L; Tanz, Robert R

2006-12-01

The objectives of this study were (1) to determine fast food restaurant prevalence in hospitals with pediatric residencies and (2) to evaluate how hospital environment affects purchase and perception of fast food. We first surveyed pediatric residency programs regarding fast food restaurants in their hospitals to determine the prevalence of fast food restaurants in these hospitals. We then surveyed adults with children after pediatric outpatient visits at 3 hospitals: hospital M with an on-site McDonald's restaurant, hospital R without McDonald's on site but with McDonald's branding, and hospital X with neither on-site McDonald's nor branding. We sought to determine attitudes toward, consumption of, and influences on purchase of fast food and McDonald's food. Fifty-nine of 200 hospitals with pediatric residencies had fast food restaurants. A total of 386 outpatient surveys were analyzed. Fast food consumption on the survey day was most common among hospital M respondents (56%; hospital R: 29%; hospital X: 33%), as was the purchase of McDonald's food (hospital M: 53%; hospital R: 14%; hospital X: 22%). McDonald's accounted for 95% of fast food consumed by hospital M respondents, and 83% of them bought their food at the on-site McDonald's. Using logistic regression analysis, hospital M respondents were 4 times more likely than respondents at the other hospitals to have purchased McDonald's food on the survey day. Visitors to hospitals M and R were more likely than those at hospital X to believe that McDonald's supported the hospital financially. Respondents at hospital M rated McDonald's food healthier than did respondents at the other hospitals. Fast food restaurants are fairly common in hospitals that sponsor pediatric residency programs. A McDonald's restaurant in a children's hospital was associated with significantly increased purchase of McDonald's food by outpatients, belief that the McDonald's Corporation supported the hospital financially, and higher rating of the healthiness of McDonald's food.

Overview of medical operations for a manned stratospheric balloon flight.

PubMed

Blue, Rebecca S; Law, Jennifer; Norton, Sean C; Garbino, Alejandro; Pattarini, James M; Turney, Matthew W; Clark, Jonathan B

2013-03-01

Red Bull Stratos was a commercial program designed to bring a test parachutist protected by a full-pressure suit via a stratospheric balloon with a pressurized capsule to 120,000 ft (36,576 m), from which he would freefall and subsequently parachute to the ground. On March 15, 2012, the Red Bull Stratos program successfully conducted a preliminary manned balloon test flight and parachute jump, reaching a final altitude of 71,581 ft (21,818 m). In light of the uniqueness of the operation and medical threats faced, a comprehensive medical plan was needed to ensure prompt and efficient response to any medical contingencies. This report will serve to discuss the medical plans put into place before the first manned balloon flight and the actions of the medical team during that flight. The medical operations developed for this program will be systematically evaluated, particularly, specific recommendations for improvement in future high-altitude and commercial space activities. A multipronged approach to medical support was developed, consisting of event planning, medical personnel, equipment, contingency-specific considerations, and communications. Medical operations were found to be highly successful when field-tested during this stratospheric flight, and the experience allowed for refinement of medical operations for future flights. The lessons learned and practices established for this program can easily be used to tailor a plan specific to other aviation or spaceflight events.

Dynamic multi-coil tailored excitation for transmit B1 correction at 7 Tesla.

PubMed

Umesh Rudrapatna, S; Juchem, Christoph; Nixon, Terence W; de Graaf, Robin A

2016-07-01

Tailored excitation (TEx) based on interspersing multiple radio frequency pulses with linear gradient and higher-order shim pulses can be used to obtain uniform flip angle in the presence of large radio frequency transmission (B 1+) inhomogeneity. Here, an implementation of dynamic, multislice tailored excitation using the recently developed multi-coil nonlinear shim hardware (MC-DTEx) is reported. MC-DTEx was developed and tested both in a phantom and in vivo at 7 T, and its efficacy was quantitatively assessed. Predicted outcomes of MC-DTEx and DTEx based on spherical harmonic shims (SH-DTEx) were also compared. For a planned 30 ° flip angle, in a phantom, the standard deviation in excitation improved from 28% (regular excitation) to 12% with MC-DTEx. The SD in in vivo excitation improved from 22 to 12%. The improvements achieved with experimental MC-DTEx closely matched the theoretical predictions. Simulations further showed that MC-DTEx outperforms SH-DTEx for both scenarios. Successful implementation of multislice MC-DTEx is presented and is shown to be capable of homogenizing excitation over more than twofold B 1+ variations. Its benefits over SH-DTEx are also demonstrated. A distinct advantage of MC hardware over SH shim hardware is the absence of significant eddy current effects, which allows for a straightforward, multislice implementation of MC-DTEx. Magn Reson Med 76:83-93, 2016. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.

SSPF Operational Upgrades

NASA Image and Video Library

2016-11-15

During a ribbon cutting ceremony in the high bay of the Space Station Processing Facility at NASA's Kennedy Space Center in Florida, center director Bob Cabana, far left, is joined by Bill Dowdell, Kennedy's International Space Station technical director, Josephine Burnett, director of Exploration Research and Technology, Andy Allen, Jacobs vice president and general manager and Test and Operations Support Contract program manager, and Jeff McAlear, Jacobs director of Processing Services. The event celebrated completion of facility modifications to improve processing and free up zones tailored to a variety of needs supporting a robust assortment of space-bound hardware including NASA programs and commercial space companies.

The Shock and Vibration Digest. Volume 14, Number 11

DTIC Science & Technology

1982-11-01

cooled reactor 1981) ( HTGR ) core under seismic excitation his been developed . N82-18644 The computer program can be used to predict the behavior (In...French) of the HTGR core under seismic excitation. Key Words: Computer programs , Modal analysis, Beams, Undamped structures A computation method is...30) PROGRAMMING c c Dale and Cohen [221 extended the method of McMunn and Plunkett [201 developed a compute- McMunn and Plunkett to continuous systems

Collaborative Employee Wellness: Living Healthy With Diabetes.

PubMed

Hovatter, Joan McGarvev; Cooke, Catherine E; de Bittner, Magaly Rodriguez

Innovative approaches to managing an employee population with a high prevalence of type 2 diabetes mellitus can mitigate costs for employers by improving employees' health. This article describes such an approach at McCormick & Company, Inc., where participants had statistically significant improvements in weight, average plasma glucose concentration (also called glycated hemoglobin or A1c) and cholesterol. A simulation analysis applying the findings of the study population to Maryland employees with a baseline A1c of greater than 6.0% showed that participation in the program could improve glycemic control in these patients, reducing the A1 c by 0.24% on average, with associated cost savings for the employer.

Antimicrobial stewardship program in a Malaysian district hospital: First year experience

PubMed Central

Sing, Diana Yap Fui; Boo, Yang Liang; Mukhlis, Roshalina; Chin, Pek Woon; Hoo, Fan Kee

2016-01-01

Backgrounds & Objective: Antimicrobial resistance is an alarming public health threat that requires urgent global solution. Implementation of antimicrobial stewardship program (ASP) is an essential practice element for healthcare institutions in gate-keeping judicious antimicrobial use. This study highlighted the development, first year experience, and result of the implementation of ASP utilizing persuasive and restrictive approaches in a Malaysian district hospital. Methods: An observational study was conducted between January 2015 to December 2015 on implementation of ASP among hospitalized inpatients age 12 years old and above. Results: Recommendations were provided for 60% of cases (110 patients) with the average acceptance rate of 83.33%. Majority of the interventions were to stop the antimicrobial therapy (30.3%), and the most common audited antimicrobials was Piperacillin/Tazobactam (25.5%), followed by Meropenem (11.82%), Amoxicillin/Clavulanate and Vancomycin (8.18%) respectively. The concordance rate towards authorization policy was increased in 2015 (71.59% of cases) as compared before the implementation of ASP in 2014 (60.6% of cases). Restrictive enforcement under ASP had been shown to improve significantly adherence rate towards antimicrobials authorization policy (p-value: 0.004). Conclusion: ASP was successfully implemented in a district hospital. Future studies on its clinical outcomes are important to evaluate its effectiveness as well as focus on the improvement to the pre-existing strategies and measures. PMID:27648056

17 CFR 8.18 - Decision.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION EXCHANGE PROCEDURES FOR DISCIPLINARY, SUMMARY, AND MEMBERSHIP DENIAL ACTIONS Disciplinary Procedure § 8.18 Decision. Promptly following a hearing conducted in accordance with § 8.17, the disciplinary committee shall render a written decision...

26 CFR 1.818-3 - Amortization of premium and accrual of discount.

Code of Federal Regulations, 2010 CFR

2010-04-01

... required under section 818(b) on account of accruable discounts. (f) Denial of double inclusion. Any amount... section shall not be includible in gross income under section 1232(a) (relating to the taxation of bonds...

Review of "The Effect of Special Education Vouchers on Public School Achievement: Evidence from Florida's McKay Scholarship Program"

ERIC Educational Resources Information Center

Yun, John T.

2008-01-01

A new report published by the Manhattan Institute for Education Policy, "The Effect of Special Education Vouchers on Public School Achievement: Evidence from Florida's McKay Scholarship Program," attempts to examine the complex issue of how competition introduced through school vouchers affects student outcomes in public schools. The…

Options in Education Transcript: Program No. 138: "Beyond Bakke."

ERIC Educational Resources Information Center

George Washington Univ., Washington, DC. Inst. for Educational Leadership.

In this transcript of a radio program about the Bakke case, a news team covers the following topics: (1) Vernon Jordan's admonitions to use restraint in assessing the implications of Bakke; (2) blacks' suspicions about affirmative action; (3) Robert McKay's thoughts on the meaning of Bakke; (4) McGeorge Bundy's thoughts on the Harvard Admissions…

An Evaluation of the McRel Thinking Skills Program.

ERIC Educational Resources Information Center

Marzano, Robert J.

This report summarizes the results of an evaluation of the thinking skills model/program developed at the Mid-continent Regional Educational Laboratory (McREL). Participating were 19 primary, 32 upper elementary, 10 junior high, and 16 senior high school teachers at four sites varying in size and locale. Providing a framework for teaching a wide…

An Evidence Based Approach to Designing Medical Support for Long Duration, Interplanetary Missions

NASA Technical Reports Server (NTRS)

Watkins, S. D.; McGrath, T. L.; Bauman, D. K.; Wu, J. H.; Barsten, K. N.; Barr, Y. R.; Kerstman, E. L.

2011-01-01

The Exploration Medical Capability (ExMC) element is one of six elements under NASA's Human Research Program (HRP). The goal of the ExMC element is to address the risk of the "inability to adequately recognize or treat an ill or injured crewmember." This poster highlights the evidence-based approach that the ExMC element has taken to address this goal, and the ExMC element's current areas of interest.

76 FR 55869 - Notice of Funding Availability: Inviting Applications for the McGovern-Dole International Food...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-09

... Applications for the McGovern-Dole International Food for Education and Child Nutrition Program; Correction... Federal Register on July 28, 2011, inviting proposals for the McGovern-Dole International Food for... eligibility requirements, makes minor changes to the application and review process, and provides updates to...

Perceptions about Teacher Leadership: Do Teacher Leaders and Administrators Share a Common Ground?

ERIC Educational Resources Information Center

Uribe-Flórez, Lida J.; Al-Rawashdeh, Amneh; Morales, Sara

2014-01-01

In 2010, the Mathematically Connected Communities Leadership Institute for Teachers (MC[superscript 2]-LIFT) started with a vision for preparing teachers to lead the construction of appropriate learning environments in their schools and districts (MC[superscript 2]-Lift Proposal, 2009). During this two-year program, MC[superscript 2]-LIFT prepared…

Training Researchers in Cultural Psychiatry: The McGill-CIHR Strategic Training Program

ERIC Educational Resources Information Center

Kirmayer, Laurence J.; Rousseau, Cecile; Corin, Ellen; Groleau, Danielle

2008-01-01

Objectives: The authors aim to summarize the pedagogical approaches and curriculum used in the training of researchers in cultural psychiatry at the Division of Social and Transcultural Psychiatry at McGill University. Method: We reviewed available published and unpublished reports on the history and development of the McGill cultural psychiatry…

Why the McKinsey Reports Will Not Improve School Systems

ERIC Educational Resources Information Center

Coffield, Frank

2012-01-01

In the last four years McKinsey and Company have produced two highly influential reports on how to improve school systems. The first McKinsey report "How the world's best-performing school systems come out on top" has since its publication in 2007 been used to justify change in educational policy and practice in England and many other…

Multiconfigurational short-range density-functional theory for open-shell systems

NASA Astrophysics Data System (ADS)

Hedegârd, Erik Donovan; Toulouse, Julien; Jensen, Hans Jørgen Aagaard

2018-06-01

Many chemical systems cannot be described by quantum chemistry methods based on a single-reference wave function. Accurate predictions of energetic and spectroscopic properties require a delicate balance between describing the most important configurations (static correlation) and obtaining dynamical correlation efficiently. The former is most naturally done through a multiconfigurational (MC) wave function, whereas the latter can be done by, e.g., perturbation theory. We have employed a different strategy, namely, a hybrid between multiconfigurational wave functions and density-functional theory (DFT) based on range separation. The method is denoted by MC short-range DFT (MC-srDFT) and is more efficient than perturbative approaches as it capitalizes on the efficient treatment of the (short-range) dynamical correlation by DFT approximations. In turn, the method also improves DFT with standard approximations through the ability of multiconfigurational wave functions to recover large parts of the static correlation. Until now, our implementation was restricted to closed-shell systems, and to lift this restriction, we present here the generalization of MC-srDFT to open-shell cases. The additional terms required to treat open-shell systems are derived and implemented in the DALTON program. This new method for open-shell systems is illustrated on dioxygen and [Fe(H2O)6]3+.

Improved Cloud Detection Utilizing Defense Meteorological Satellite Program near Infrared Measurements

DTIC Science & Technology

1982-01-27

Visible 3. 3 Ea r th Location, Colocation, and Normalization 4. IMAGE ANALYSIS 4. 1 Interactive Capabilities 4.2 Examples 5. AUTOMATED CLOUD...computer Interactive Data Access System (McIDAS) before image analysis and algorithm development were done. Earth-location is an automated procedure to...the factor l / s in (SSE) toward the gain settings given in Table 5. 4. IMAGE ANALYSIS 4.1 Interactive Capabilities The development of automated

Contractor Past Performance Information: An Analysis of Assessment Narratives and Objective Ratings

DTIC Science & Technology

2015-04-30

narratives, and improving the disclosure of CPARS program office audit results (Black et al., 2014, pp. 48–49). Summary, Conclusions, and Recommendations...office audit results (Black et al., 2014, pp. 44–49). Recommendations Based on our conclusions, we identified the following five recommendations...and information technology (5th ed.). New York, NY: McGraw -Hill. Freeman, R. E. (1984). Strategic management: A stakeholder approach. Boston, MA

MC-TESTER v. 1.23: A universal tool for comparisons of Monte Carlo predictions for particle decays in high energy physics

NASA Astrophysics Data System (ADS)

Davidson, N.; Golonka, P.; Przedziński, T.; Waş, Z.

2011-03-01

Theoretical predictions in high energy physics are routinely provided in the form of Monte Carlo generators. Comparisons of predictions from different programs and/or different initialization set-ups are often necessary. MC-TESTER can be used for such tests of decays of intermediate states (particles or resonances) in a semi-automated way. Since 2002 new functionalities were introduced into the package. In particular, it now works with the HepMC event record, the standard for C++ programs. The complete set-up for benchmarking the interfaces, such as interface between τ-lepton production and decay, including QED bremsstrahlung effects is shown. The example is chosen to illustrate the new options introduced into the program. From the technical perspective, our paper documents software updates and supplements previous documentation. As in the past, our test consists of two steps. Distinct Monte Carlo programs are run separately; events with decays of a chosen particle are searched, and information is stored by MC-TESTER. Then, at the analysis step, information from a pair of runs may be compared and represented in the form of tables and plots. Updates introduced in the program up to version 1.24.4 are also documented. In particular, new configuration scripts or script to combine results from multitude of runs into single information file to be used in analysis step are explained. Program summaryProgram title: MC-TESTER, version 1.23 and version 1.24.4 Catalog identifier: ADSM_v2_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADSM_v2_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 250 548 No. of bytes in distributed program, including test data, etc.: 4 290 610 Distribution format: tar.gz Programming language: C++, FORTRAN77 Tested and compiled with: gcc 3.4.6, 4.2.4 and 4.3.2 with g77/gfortran Computer: Tested on various platforms Operating system: Tested on operating systems: Linux SLC 4.6 and SLC 5, Fedora 8, Ubuntu 8.2 etc. Classification: 11.9 External routines: HepMC ( https://savannah.cern.ch/projects/hepmc/), PYTHIA8 ( http://home.thep.lu.se/~torbjorn/Pythia.html), LaTeX ( http://www.latex-project.org/) Catalog identifier of previous version: ADSM_v1_0 Journal reference of previous version: Comput. Phys. Comm. 157 (2004) 39 Does the new version supersede the previous version?: Yes Nature of problem: The decays of individual particles are well defined modules of a typical Monte Carlo program chain in high energy physics. A fast, semi-automatic way of comparing results from different programs is often desirable for the development of new programs, in order to check correctness of the installations or for discussion of uncertainties. Solution method: A typical HEP Monte Carlo program stores the generated events in event records such as HepMC, HEPEVT or PYJETS. MC-TESTER scans, event by event, the contents of the record and searches for the decays of the particle under study. The list of the found decay modes is successively incremented and histograms of all invariant masses which can be calculated from the momenta of the particle decay products are defined and filled. The outputs from the two runs of distinct programs can be later compared. A booklet of comparisons is created: for every decay channel, all histograms present in the two outputs are plotted and parameter quantifying shape difference is calculated. Its maximum over every decay channel is printed in the summary table. Reasons for new version: Interface for HepMC Event Record is introduced. Setup for benchmarking the interfaces, such as τ-lepton production and decay, including QED bremsstrahlung effects is introduced as well. This required significant changes in the algorithm. As a consequence, a new version of the code was introduced. Restrictions: Only the first 200 decay channels that were found will initialize histograms and if the multiplicity of decay products in a given channel was larger than 7, histograms will not be created for that channel. Additional comments: New features: HepMC interface, use of lists in definition of histograms and decay channels, filters for decay products or secondary decays to be omitted, bug fixing, extended flexibility in representation of program output, installation configuration scripts, merging multiple output files from separate generations. Running time: Varies substantially with the analyzed decay particle, but generally speed estimation of the old version remains valid. On a PC/Linux with 2.0 GHz processors MC-TESTER increases the run time of the τ-lepton Monte Carlo program TAUOLA by 4.0 seconds for every 100 000 analyzed events (generation itself takes 26 seconds). The analysis step takes 13 seconds; LATEX processing takes additionally 10 seconds. Generation step runs may be executed simultaneously on multiprocessor machines.

Constant-pH Molecular Dynamics Simulations for Large Biomolecular Systems

DOE PAGES

Radak, Brian K.; Chipot, Christophe; Suh, Donghyuk; ...

2017-11-07

We report that an increasingly important endeavor is to develop computational strategies that enable molecular dynamics (MD) simulations of biomolecular systems with spontaneous changes in protonation states under conditions of constant pH. The present work describes our efforts to implement the powerful constant-pH MD simulation method, based on a hybrid nonequilibrium MD/Monte Carlo (neMD/MC) technique within the highly scalable program NAMD. The constant-pH hybrid neMD/MC method has several appealing features; it samples the correct semigrand canonical ensemble rigorously, the computational cost increases linearly with the number of titratable sites, and it is applicable to explicit solvent simulations. The present implementationmore » of the constant-pH hybrid neMD/MC in NAMD is designed to handle a wide range of biomolecular systems with no constraints on the choice of force field. Furthermore, the sampling efficiency can be adaptively improved on-the-fly by adjusting algorithmic parameters during the simulation. Finally, illustrative examples emphasizing medium- and large-scale applications on next-generation supercomputing architectures are provided.« less

Constant-pH Molecular Dynamics Simulations for Large Biomolecular Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Radak, Brian K.; Chipot, Christophe; Suh, Donghyuk

We report that an increasingly important endeavor is to develop computational strategies that enable molecular dynamics (MD) simulations of biomolecular systems with spontaneous changes in protonation states under conditions of constant pH. The present work describes our efforts to implement the powerful constant-pH MD simulation method, based on a hybrid nonequilibrium MD/Monte Carlo (neMD/MC) technique within the highly scalable program NAMD. The constant-pH hybrid neMD/MC method has several appealing features; it samples the correct semigrand canonical ensemble rigorously, the computational cost increases linearly with the number of titratable sites, and it is applicable to explicit solvent simulations. The present implementationmore » of the constant-pH hybrid neMD/MC in NAMD is designed to handle a wide range of biomolecular systems with no constraints on the choice of force field. Furthermore, the sampling efficiency can be adaptively improved on-the-fly by adjusting algorithmic parameters during the simulation. Finally, illustrative examples emphasizing medium- and large-scale applications on next-generation supercomputing architectures are provided.« less

Achieving Gender Equality in Families: The Role of Males. Innocenti Global Seminar Summary Report (Kingston, Jamaica, May 8-18, 1995).

ERIC Educational Resources Information Center

Richardson, John

This report summarizes the proceedings of UNICEF's Global Innocenti Seminar on "Achieving Gender Equality in Families: The Role of Males." The seminar examined how, as more women become economic providers for families, the role of males in families needs to develop new dimensions so that they can contribute to improved health and…

Enhancing Involvement in Treatment Decision Making by Women With Breast Cancer

DTIC Science & Technology

2006-07-01

Hamilton, Canada 1984 BHSc ( Physiotherapy ) McMaster University, Hamilton, Canada 1978 Diploma in Physiotherapy , Mohawk College, Hamilton...Canada Certificate in Physiotherapy , McMaster University, Hamilton, Canada CURRENT STATUS AT MCMASTER UNIVERSITY 2001-2006 Associate Clinical...United Kingdom 1985-1991 Clinical Education Co-ordinator, Mohawk-McMaster Physiotherapy Program, Mohawk College of Applied Arts and Technology

Journey to the Doctorate: Motivating Factors for Persistence and Completion of Doctoral Programs among McNair Scholars

ERIC Educational Resources Information Center

Baness King, Deborah

2011-01-01

Using a qualitative approach, this study investigated the perceptions of motivating factors for persistence and completion of the doctorate among low income, first generation and students of color that participated in the federally funded Ronald E. McNair Postbaccalaureate Achievement Program. Purposive sampling was used to obtain a pool of nine…

An Exploratory Study of the Experiences of Recent Graduates Who Participated in the Ronald E. McNair Postbaccalaureate Achievement Program

ERIC Educational Resources Information Center

Thomas, Zaducka T. C.

2012-01-01

The purpose of this qualitative study was to explore the experiences of recent graduates who participated in the Ronald E. McNair Postbaccalaureate Achievement Program at a medium-size southeastern university. This research used a phenomenological approach, as well as qualitative interviews, to provide a detailed and insightful description about…

Effectiveness of McGraw Hill's "Jamestown Reading Navigator" in Grades 9-10: A Study of Intensive Reading Classes in Miami-Dade High Schools

ERIC Educational Resources Information Center

Lazarev, Valeriy; Atienza, Sara; Lai, Garrett; Ma, Boya; Sterling, Laurel

2010-01-01

A quasi-experimental study designed to provide evidence of the effectiveness of the "Jamestown Reading Navigator" ("JRN") program for students in grades 9-10 was conducted in the Miami Dade Public School District (MDCSD). "Jamestown Reading Navigator" is a reading intervention program developed by McGraw-Hill…

Interaction between renal function and percutaneous edge-to-edge mitral valve repair using MitraClip.

PubMed

Kaneko, Hidehiro; Neuss, Michael; Schau, Thomas; Weissenborn, Jens; Butter, Christian

2017-02-01

MitraClip (MC; Abbott Vascular, Menlo Park, CA, USA) is a treatment option for mitral regurgitation. Renal dysfunction is closely associated with cardiovascular disease. However, the influence of renal function in MC remains not fully understood. In this study, we aimed to clarify the association between renal function and MC. We examined 206 consecutive patients who underwent MC and divided patients into 3 groups according to estimated glomerular filtration rate (eGFR), normal eGFR (≥60mL/min/1.73m 2 ) (n=70), mild chronic kidney disease (CKD) (30-59mL/min/1.73m 2 ) (n=106), and severe CKD (<30mL/min/1.73m 2 ) (n=30). N-terminal pro-B type natriuretic peptide (NT-pro BNP) levels increased with decreasing eGFR. Kaplan-Meier curves revealed that the long-term survival rate significantly decreased with eGFR. After adjustment with the covariates, severe CKD was still associated with mortality. Improved renal function was observed in 30% and associated with baseline lower NT-pro BNP levels. Patients with improved renal function had higher chronic phase survival rate. Renal dysfunction is common in MC patients and the survival rate decreased with eGFR in association with increased NT-pro BNP levels. MC may improve renal function in approximately 30% of MC patients. Improved renal function is associated with lower NT-pro BNP levels and results in satisfactory prognosis. These results implies a close association between renal function and MC treatment. Copyright © 2016 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.

Hypervelocity impact testing of the Space Station utility distribution system carrier

NASA Technical Reports Server (NTRS)

Lazaroff, Scott

1993-01-01

A two-phase, joint JSC and McDonnell Douglas Aerospace-Huntington Beach hypervelocity impact (HVI) test program was initiated to develop an improved understanding of how meteoroid and orbital debris (M/OD) impacts affect the Space Station Freedom (SSF) avionic and fluid lines routed in the Utility Distribution System (UDS) carrier. This report documents the first phase of the test program which covers nonpowered avionic line segment and pressurized fluid line segment HVI testing. From these tests, a better estimation of avionic line failures is approximately 15 failures per year and could very well drop to around 1 or 2 avionic line failures per year (depending upon the results of the second phase testing of the powered avionic line at White Sands). For the fluid lines, the initial McDonnell Douglas analysis calculated 1 to 2 line failures over a 30 year period. The data obtained from these tests indicate the number of predicted fluid line failures increased slightly to as many as 3 in the first 10 years and up to 15 for the entire 30 year life of SSF.

The plant metacaspase AtMC1 in pathogen-triggered programmed cell death and aging: functional linkage with autophagy

PubMed Central

Coll, N S; Smidler, A; Puigvert, M; Popa, C; Valls, M; Dangl, J L

2014-01-01

Autophagy is a major nutrient recycling mechanism in plants. However, its functional connection with programmed cell death (PCD) is a topic of active debate and remains not well understood. Our previous studies established the plant metacaspase AtMC1 as a positive regulator of pathogen-triggered PCD. Here, we explored the linkage between plant autophagy and AtMC1 function in the context of pathogen-triggered PCD and aging. We observed that autophagy acts as a positive regulator of pathogen-triggered PCD in a parallel pathway to AtMC1. In addition, we unveiled an additional, pro-survival homeostatic function of AtMC1 in aging plants that acts in parallel to a similar pro-survival function of autophagy. This novel pro-survival role of AtMC1 may be functionally related to its prodomain-mediated aggregate localization and potential clearance, in agreement with recent findings using the single budding yeast metacaspase YCA1. We propose a unifying model whereby autophagy and AtMC1 are part of parallel pathways, both positively regulating HR cell death in young plants, when these functions are not masked by the cumulative stresses of aging, and negatively regulating senescence in older plants. PMID:24786830

63. McMILLAN DAM Photographic copy of construction drawing dated ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

63. McMILLAN DAM - Photographic copy of construction drawing dated July 19, 1937 (from aperture card located at Bureau of Reclamation, Salt Lake City). McMILLAN DAM - GENERAL PLAN AND SECTIONS WITH PROPOSED IMPROVEMENTS - Carlsbad Irrigation District, McMillan Dam, On Pecos River, 13 miles North of Carlsbad, Carlsbad, Eddy County, NM

United States Air Force Weapons Laboratory Research Scholar Program, 1983-1984.

DTIC Science & Technology

1984-10-01

voltage upon passing through an RC circuit .) The phase shift is given by = tan-Tf (3) * where T is the cavity lifetime and f is the modulation ...spark in air at the external terminals of a filter module has * S. . . . . .. S ** . * * * * Page 8-18 approximately the same effect on the circuit as a... module usually contains a metal oxide varistor(s), and perhaps also 3 an RFI filter circuit . We shall discuss line conditioners and surge protection

Is Mc Leod's Patent Pending Naturoptic Method for Restoring Healthy Vision Easy and Verifiable?

NASA Astrophysics Data System (ADS)

Niemi, Paul; McLeod, David; McLeod, Roger

2006-10-01

RDM asserts that he and people he has trained can assign visual tasks from standard vision assessment charts, or better replacements, proceeding through incremental changes and such rapid improvements that healthy vision can be restored. Mc Leod predicts that in visual tasks with pupil diameter changes, wavelengths change proportionally. A longer, quasimonochromatic wavelength interval is coincident with foveal cones, and rods. A shorter, partially overlapping interval separately aligns with extrafoveal cones. Wavelengths follow the Airy disk radius formula. Niemi can evaluate if it is true that visual health merely requires triggering and facilitating the demands of possibly overridden feedback signals. The method and process are designed so that potential Naturopathic and other select graduate students should be able to self-fund their higher- level educations from preferential franchising arrangements of earnings while they are in certain programs.

Three Dimensional Spherical Display Systems and McIDAS: Tools for Science, Education and Outreach

NASA Astrophysics Data System (ADS)

Kohrs, R.; Mooney, M. E.

2010-12-01

The Space Science and Engineering Center (SSEC) and Cooperative Institute for Meteorological Satellite Studies (CIMSS) at the University of Wisconsin are now using a 3D spherical display system and their Man computer Data Access System (McIDAS)-X and McIDAS-V as outreach tools to demonstrate how scientists and forecasters utilize satellite imagery to monitor weather and climate. Our outreach program displays orbits and data coverage of geostationary and polar satellites and demonstrates how each is beneficial for the remote sensing of Earth. Global composites of visible, infrared and water vapor images illustrate how satellite instruments collect data from different bands of the electromagnetic spectrum to monitor global weather patterns 24 hours a day. Captivating animations on spherical display systems are proving to be much more intuitive than traditional 2D displays, enabling audiences to view satellites orbiting above real-time weather systems circulating the entire globe. Complimenting the 3D spherical display system are the UNIX-based McIDAS-X and Java-based McIDAS-V software packages. McIDAS is used to composite the real-time global satellite data and create other weather related derived products. Client and server techniques used by these software packages provide the opportunity to continually update the real-time content on our globe. The enhanced functionality of McIDAS-V extends our outreach program by allowing in-depth interactive 4-dimensional views of the imagery previously viewed on the 3D spherical display system. An important goal of our outreach program is the promotion of remote sensing research and technology at SSEC and CIMSS. The 3D spherical display system has quickly become a popular tool to convey societal benefits of these endeavors. Audiences of all ages instinctively relate to recent weather events which keeps them engaged in spherical display presentations. McIDAS facilitates further exploration of the science behind the weather phenomena. Audience feedback fuels the collaborative efforts of outreach specialists and computer programmers which provides continuous evolution of the 3D displays and McIDAS. This iterative presentation strategy is proving to be beneficial to our outreach program as seen by the success of our workshops, educational lectures and temporary exhibits at high visibility venues such as Madison Children’s Museum, the Milwaukee Public Museum and EAA AirVenture Museum. 3D Spherical Display System and McIDAS-V depiction of Hurricane Wilma

Design of the Quality of Life in Motion (QLIM) study: a randomized controlled trial to evaluate the effectiveness and cost-effectiveness of a combined physical exercise and psychosocial training program to improve physical fitness in children with cancer.

PubMed

Braam, Katja I; van Dijk, Elisabeth M; Veening, Margreet A; Bierings, Marc B; Merks, Johannes H M; Grootenhuis, Martha A; Chinapaw, Mai J M; Sinnema, Gerben; Takken, Tim; Huisman, Jaap; Kaspers, Gertjan J L; van Dulmen-den Broeder, Eline

2010-11-11

Childhood cancer and its treatment have considerable impact on a child's physical and mental wellbeing. Especially long-term administration of chemotherapy and/or radiotherapy impairs physical fitness both during and after therapy, when children often present with muscle weakness and/or low cardiorespiratory fitness. Physical exercise can improve these two elements of physical fitness, but the positive effects of physical exercise might be further increased when a child's wellbeing is simultaneously enhanced by psychosocial training. Feeling better may increase the willingness and motivation to engage in sports activities. Therefore, this multi-centre study evaluates the short and long-term changes in physical fitness of a child with a childhood malignancy, using a combined physical exercise and psychosocial intervention program, implemented during or shortly after treatment. Also examined is whether positive effects on physical fitness reduce inactivity-related adverse health problems, improve quality of life, and are cost-effective. This multi-centre randomized controlled trial compares a combined physical and psychosocial intervention program for children with cancer, with care as usual (controls). Children with cancer (aged 8-18 years) treated with chemotherapy and/or radiotherapy, and who are no longer than 1 year post-treatment, are eligible for participation. A total of 100 children are being recruited from the paediatric oncology/haematology departments of three Dutch university medical centres. Patients are stratified according to pubertal stage (girls: age ≤10 or >10 years; boys: ≤11 or >11 years), type of malignancy (haematological or solid tumour), and moment of inclusion into the study (during or after treatment), and are randomly assigned to the intervention or control group. Childhood cancer patients undergoing long-term cancer therapy may benefit from a combined physical exercise and psychosocial intervention program since it may maintain or enhance their physical fitness and increase their quality of life. However, the feasibility, patient need, and effectiveness of such a program should be established before the program can be implemented as part of standard care. NTR1531 (The Netherlands National Trial Register).

Christa McAuliffe meets other STS 51-L crewmembers

NASA Image and Video Library

1985-09-10

S85-39943 (9 Sept. 1985) --- Sharon Christa McAuliffe, STS-51L citizen observer/payload specialist representing the Teacher in Space Program, meets the other STS-51L crew members. The crew members pictured are (l.-r.) astronauts Michael J. Smith, pilot; Ronald E. McNair, mission specialist; and Francis R. (Dick) Scobee, mission commander. Photo credit: NASA

Records of Aedes albopictus, Aedes aegypti and Aedes triseriatus from the U.S. Air Force Ovitrapping Program - 1989.

DTIC Science & Technology

1989-12-01

PERSONAL AUTHOR(S) McHugh, Chad P., and Hanny , Paul A. 13a. TYPE OF REPORT 13b. TIME COVERED 14. DATE OF REPORT (Year, Month, Day) 15. PAGE COUNT Fina I...Ovitrapping Program - 1989 C.P. McHugh and P.A. Hanny Epidemiology Division, USAF School of Aerospace Medicine, Human Systems Division (AFSC), Brooks AFB

Assessing the Effects of the "McGraw Hill Phonemic Awareness" Program with Preschool Children with Developmental Delays: A Case Study

ERIC Educational Resources Information Center

Isakson, Lisa; Marchand-Martella, Nancy; Martella, Ronald C.

2011-01-01

This study assessed the effects of "McGraw Hill Phonemic Awareness" on the phonemic awareness skills of 5 preschool children with developmental delays. The children received 60 of the 110 lessons included in this program over 5 months. They were pre- and posttested using the kindergarten level Initial Sound Fluency and Phoneme…

Discrete Time McKean–Vlasov Control Problem: A Dynamic Programming Approach

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pham, Huyên, E-mail: pham@math.univ-paris-diderot.fr; Wei, Xiaoli, E-mail: tyswxl@gmail.com

We consider the stochastic optimal control problem of nonlinear mean-field systems in discrete time. We reformulate the problem into a deterministic control problem with marginal distribution as controlled state variable, and prove that dynamic programming principle holds in its general form. We apply our method for solving explicitly the mean-variance portfolio selection and the multivariate linear-quadratic McKean–Vlasov control problem.

Microphysics of Clouds with the Relaxed Arakawa-Schubert Scheme (McRAS). Part I: Design and Evaluation with GATE Phase III Data.

NASA Astrophysics Data System (ADS)

Sud, Y. C.; Walker, G. K.

1999-09-01

A prognostic cloud scheme named McRAS (Microphysics of Clouds with Relaxed Arakawa-Schubert Scheme) has been designed and developed with the aim of improving moist processes, microphysics of clouds, and cloud-radiation interactions in GCMs. McRAS distinguishes three types of clouds: convective, stratiform, and boundary layer. The convective clouds transform and merge into stratiform clouds on an hourly timescale, while the boundary layer clouds merge into the stratiform clouds instantly. The cloud condensate converts into precipitation following the autoconversion equations of Sundqvist that contain a parametric adaptation for the Bergeron-Findeisen process of ice crystal growth and collection of cloud condensate by precipitation. All clouds convect, advect, as well as diffuse both horizontally and vertically with a fully interactive cloud microphysics throughout the life cycle of the cloud, while the optical properties of clouds are derived from the statistical distribution of hydrometeors and idealized cloud geometry.An evaluation of McRAS in a single-column model (SCM) with the Global Atmospheric Research Program Atlantic Tropical Experiment (GATE) Phase III data has shown that, together with the rest of the model physics, McRAS can simulate the observed temperature, humidity, and precipitation without discernible systematic errors. The time history and time mean in-cloud water and ice distribution, fractional cloudiness, cloud optical thickness, origin of precipitation in the convective anvils and towers, and the convective updraft and downdraft velocities and mass fluxes all simulate a realistic behavior. Some of these diagnostics are not verifiable with data on hand. These SCM sensitivity tests show that (i) without clouds the simulated GATE-SCM atmosphere is cooler than observed; (ii) the model's convective scheme, RAS, is an important subparameterization of McRAS; and (iii) advection of cloud water substance is helpful in simulating better cloud distribution and cloud-radiation interaction. An evaluation of the performance of McRAS in the Goddard Earth Observing System II GCM is given in a companion paper (Part II).

Technical Note: Defining cyclotron-based clinical scanning proton machines in a FLUKA Monte Carlo system.

PubMed

Fiorini, Francesca; Schreuder, Niek; Van den Heuvel, Frank

2018-02-01

Cyclotron-based pencil beam scanning (PBS) proton machines represent nowadays the majority and most affordable choice for proton therapy facilities, however, their representation in Monte Carlo (MC) codes is more complex than passively scattered proton system- or synchrotron-based PBS machines. This is because degraders are used to decrease the energy from the cyclotron maximum energy to the desired energy, resulting in a unique spot size, divergence, and energy spread depending on the amount of degradation. This manuscript outlines a generalized methodology to characterize a cyclotron-based PBS machine in a general-purpose MC code. The code can then be used to generate clinically relevant plans starting from commercial TPS plans. The described beam is produced at the Provision Proton Therapy Center (Knoxville, TN, USA) using a cyclotron-based IBA Proteus Plus equipment. We characterized the Provision beam in the MC FLUKA using the experimental commissioning data. The code was then validated using experimental data in water phantoms for single pencil beams and larger irregular fields. Comparisons with RayStation TPS plans are also presented. Comparisons of experimental, simulated, and planned dose depositions in water plans show that same doses are calculated by both programs inside the target areas, while penumbrae differences are found at the field edges. These differences are lower for the MC, with a γ(3%-3 mm) index never below 95%. Extensive explanations on how MC codes can be adapted to simulate cyclotron-based scanning proton machines are given with the aim of using the MC as a TPS verification tool to check and improve clinical plans. For all the tested cases, we showed that dose differences with experimental data are lower for the MC than TPS, implying that the created FLUKA beam model is better able to describe the experimental beam. © 2017 The Authors. Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine.

Inflammatory response and treatment tolerance of long-term infusion of the anti-GD2 antibody ch14.18/CHO in combination with interleukin-2 in patients with high-risk neuroblastoma.

PubMed

Ceylan, Kiraz; Jahns, Luciana J; Lode, Bjoern N; Ehlert, Karoline; Kietz, Silke; Troschke-Meurer, Sascha; Siebert, Nikolai; Lode, Holger N

2018-06-01

The monoclonal anti-GD 2 antibody ch14.18/CHO in combination with IL-2 is active and effective in high-risk neuroblastoma (NB) patients. Here, we investigated the inflammatory response and treatment tolerance of long-term infusion (LTI) of ch14.18/CHO (10 × 10 mg/m 2 ; 24 hr) in combination with subcutaneous (s.c.) IL-2 in a single center program. Fifty-three NB patients received up to six cycles of 100 mg/m 2 ch14.18/CHO (d8-18, where d represents day(s)) as LTI combined with 6 × 10 6 IU/m 2 s.c. IL-2 (d1-5; 8-12) and 160 mg/m 2 oral 13-cis retinoic acid (RA) (d19-32). Side effects of ch14.18/CHO and IL-2 treatment require hospitalization of patients on d8. Treatment tolerance was evaluated daily with clinical parameters (body temperature, vital signs, Lansky performance status, requirement of i.v. concomitant medication) to define an outpatient candidate status. sIL-2-R and C-reactive protein values were determined to assess the inflammatory response. LTI of ch14.18/CHO (d8-18) in combination with s.c.IL-2 (d8-12) showed an acceptable treatment tolerance that allowed all patients to receive part of the treatment as an outpatient (median time point of discharge: d15 for all cycles). The treatment tolerance improved from cycle to cycle and the time to become an outpatient candidate decreased from d15 to d13 in subsequent cycles. Clinical and laboratory parameters indicate a maximum inflammatory response at d11 of each cycle. Interestingly, the soluble IL-2 receptor remained increased at baseline of the next cycle indicating immune activation over the entire treatment period of 6 months. LTI of ch14.18/CHO combined with s.c.IL-2 shows an improved tolerance in subsequent cycles allowing outpatient treatment. © 2018 Wiley Periodicals, Inc.

A Structured Educational Curriculum Including Online Training Positively Impacts American Board of Surgery In-Training Examination Scores.

PubMed

Kelly, Dympna M; London, Daniel A; Siperstein, Allan; Fung, John J; Walsh, Matthew R

2015-01-01

To assess the effect of a structured postgraduate year 1 educational curriculum, including online surgical training, on American Board of Surgery In-Training Examination (ABSITE) scores. This was a retrospective cohort study. The study was performed in an academic surgical residency program in a tertiary care hospital, Cleveland Clinic Foundation, Cleveland, Ohio. The participants were 140 surgical postgraduate year 1 residents from 2000 to 2009. Interns from 2000 to 2004 were grouped together and completed a self-directed learning curriculum. Interns from 2005 to 2009 participated in a structured educational curriculum that included lectures and the use of an online program. Lectures were based on the American College of Surgeons curriculum. The online program consisted of 8 to 12 hours of assigned tutorials and quizzes that corresponded to the lectures and 3 multiple-choice (MC) examinations. Use of a structured educational curriculum led to improved ABSITE scores (66 ± 9%) compared with that of those who had no curriculum (55 ± 10%, p < 0.001). Several variables positively correlated with the ABSITE score: United States Medical Licensing Examination step 1 score (p < 0.001), monthly quiz scores (p = 0.003), average MC examination scores (p = 0.005), lecture attendance (p = 0.02), and time spent online (p = 0.04). Multivariable analysis demonstrated that the step 1 United States Medical Licensing Examination score, time spent online, and MC examination score are predictive of total the ABSITE score. When ABSITE subscores (basic science and clinical science) were compared, the online curriculum had a greater effect on basic science subscores, whereas lectures had a greater effect on clinical science subscores. Providing surgery residents a structured curriculum with lectures and an online component positively impacts ABSITE scores. Copyright © 2015 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

Major impact: a global population policy can advance human development in the 21st century.

PubMed

Mcnamara, R S

1992-12-01

In Tokyo, Japan, former president of the World Bank, Robert McNamara, addressed the Global Industrial and Social Progress Research Institute Symposium in April 1992. He reiterated a statement he made during his first presentation as president of the World Bank in September 1968--rapid population growth is the leading obstacle to economic growth and social well-being for people living in developing countries. He called for both developed and developing countries to individually and collectively take immediate action to reduce population growth rates, otherwise coercive action will be needed. Rapid population growth prevents countries from achieving sustainable development and jeopardizes our physical environment. It also exacerbates poverty, does not improve the role and status of women, adversely affects the health of children, and does not allow children a chance at a quality life. Even if developing countries were to quickly adopt replacement level fertility rates, high birth rates in the recent past prevent them from reducing fast population growth for decades. For example, with more than 60% of females in Kenya being at least 19 years old (in Sweden they represent just 23%), the population would continue to grow rapidly for 70 years if immediate reduction to replacement level fertility occurred. Mr. McNamara emphasized than any population program must center on initiating or strengthening extensive family planning programs and increasing the rate of economic and social progress. Successful family planning programs require diverse enough family planning services and methods to meet the needs of various unique populations, stressing of family planning derived health benefits to women and children, participation of both the public and private sectors, and political commitment. McNamara calculated that a global family planning program for the year 2000 would cost about US$8 billion. He added that Japan should increase its share of funds to population growth reduction efforts.

Mobility for GCSS-MC through virtual PCs

DTIC Science & Technology

2017-06-01

their productivity. Mobile device access to GCSS-MC would allow Marines to access a required program for their mission using a form of computing ...network throughput applications with a device running on various operating systems with limited computational ability. The use of VPCs leads to a...reduced need for network throughput and faster overall execution. 14. SUBJECT TERMS GCSS-MC, enterprise resource planning, virtual personal computer

McStas 1.1: a tool for building neutron Monte Carlo simulations

NASA Astrophysics Data System (ADS)

Lefmann, K.; Nielsen, K.; Tennant, A.; Lake, B.

2000-03-01

McStas is a project to develop general tools for the creation of simulations of neutron scattering experiments. In this paper, we briefly introduce McStas and describe a particular application of the program: the Monte Carlo calculation of the resolution function of a standard triple-axis neutron scattering instrument. The method compares well with the analytical calculations of Popovici.

Installation Restoration Program Stage 3. McClellan Air Force Base, California. Remedial Investigation/Feasibility Study Groundwater Sampling and Analysis Program Data Summary

DTIC Science & Technology

1988-12-01

and do not refer to monitoring zones at McClellSn AFB. b Priority poLutant metals analyses also included U.S. EPA Methods 206.2, 245.1 and 270.2. EW a...sampling protocol, and the laboratory is audited routinely. Therefore, no corrective action other than good training and supervision is necessary. The same

DOD JPADS Programs Overview & NATO Activities

DTIC Science & Technology

2007-05-01

DOD JPADS PROGRAMS OVERVIEW & NATO ACTIVITIES Richard Benney, Joseph McGrath, Jaclyn McHugh, Andrew Meloni, Greg Noetscher, Steve Tavan1 US...May 23-26, 2005, Munich, Germany. [3] Philip D. Hattis, Thomas J. Fill, David S. Rubenstein, Robert P. Wright, and Richard J. Benney, "An Advanced...Colorado. [4] Philip Hattis, Thomas Fill, David Rubenstein, Robert Wright, Richard Benney, David LeMoine, "Status of an On-Board PC-Based Airdrop

Continuous Efforts to Develop the National System for Material Control and Accounting Training at the George Kuzmycz Training Center

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gavrilyuk, Victor I.; Kirischuk, Volodymyr; Romanova, Olena

2011-10-01

The George Kuzmycz Training Center (GKTC) for Physical Protection, Control and Accounting of Nuclear Materials was established in 1998 at the Kyiv Institute of Nuclear Research of the Ukrainian Academy of Sciences through the collaborative efforts of the United States and Ukraine. Later the European Commission (EC) joined the US in assisting with the Material Control and Accounting (MC&A) part of the GKTC training program. The Government of Ukraine designated the GKTC as the National Center responsible for providing training and methodological support for nuclear facilities and nuclear specialists in the Material Protection, Control and Accounting (MPC&A) area. To increasemore » the efficiency of the State MC&A system an essential number of new regulations, norms and rules have been developed; some of them mandate regular and more intensive training of MC&A specialists in the industry - from those working at the Nuclear Regulatory Authority of Ukraine to the personnel of nuclear facilities. To meet such regulations GKTC plans to develop next year a number of training courses under the EC contract; such courses will reflect both the specifics of Ukrainian nuclear facilities and the level of expertise of the facilities’ personnel. The NDA training laboratory, established in 2003 with US DOE financial support and technical and methodological assistance, considerably expanded the GKTC’s training capabilities for MC&A programs. Next year that lab will be supplemented with a new NM Surveillance and Containment laboratory as current plans call for under the EC contract. The US DOE is also providing funding to support that project. Under the EC contract the laboratory will be equipped with state-of-the-art, advanced surveillance and containment equipment which will strengthen and expand even further the GKTC’s training capabilities and potential. This will allow GKTC to train Ukrainian nuclear industry specialists in practically all MC&A topics. Furthermore, GKTC is planning to offer already this year and to continue offering in the future, on a regular basis, the courses that have already been developed, while continuing to develop new ones. This paper briefly describes the work done to upgrade the Ukrainian MC&A system, both at the State and at the facilities’ levels, as well as the results of efforts to develop the National System for training MC&A personnel at the GKTC. It also describes problems encountered and their solution; it includes comments, suggestions and recommendations for future activities to promote and improve the nuclear material management culture in Ukraine.« less

Availability Estimation for Facilities in Extreme Geographical Locations

NASA Technical Reports Server (NTRS)

Fischer, Gerd M.; Omotoso, Oluseun; Chen, Guangming; Evans, John W.

2012-01-01

A value added analysis for the Reliability. Availability and Maintainability of McMurdo Ground Station was developed, which will be a useful tool for system managers in sparing, maintenance planning and determining vital performance metrics needed for readiness assessment of the upgrades to the McMurdo System. Output of this study can also be used as inputs and recommendations for the application of Reliability Centered Maintenance (RCM) for the system. ReliaSoft's BlockSim. a commercial Reliability Analysis software package, has been used to model the availability of the system upgrade to the National Aeronautics and Space Administration (NASA) Near Earth Network (NEN) Ground Station at McMurdo Station in the Antarctica. The logistics challenges due to the closure of access to McMurdo Station during the Antarctic winter was modeled using a weighted composite of four Weibull distributions. one of the possible choices for statistical distributions throughout the software program and usually used to account for failure rates of components supplied by different manufacturers. The inaccessibility of the antenna site on a hill outside McMurdo Station throughout one year due to severe weather was modeled with a Weibull distribution for the repair crew availability. The Weibull distribution is based on an analysis of the available weather data for the antenna site for 2007 in combination with the rules for travel restrictions due to severe weather imposed by the administrating agency, the National Science Foundation (NSF). The simulations resulted in an upper bound for the system availability and allowed for identification of components that would improve availability based on a higher on-site spare count than initially planned.

An Interview with Joe McMann: His Life Lessons

NASA Technical Reports Server (NTRS)

McMann, Joe

2011-01-01

Pica Kahn conducted "An Interview with Joe McMann: His Life Lessons" on May 23, 2011. With over 40 years of experience in the aerospace industry, McMann has gained a wealth of knowledge. Many have been interested in his biography, progression of work at NASA, impact on the U.S. spacesuit, and career accomplishments. This interview highlighted the influences and decision-making methods that impacted his technical and management contributions to the space program. McMann shared information about the accomplishments and technical advances that committed individuals can make.

Short Hairpin RNA Gene Silencing of Prolyl Hydroxylase-2 with a Minicircle Vector Improves Neovascularization of Hindlimb Ischemia

PubMed Central

Lijkwan, Maarten A.; Hellingman, Alwine A.; Bos, Ernst J.; van der Bogt, Koen E.A.; Huang, Mei; Kooreman, Nigel G.; de Vries, Margreet R.; Peters, Hendrika A.B.; Robbins, Robert C.; Quax, Paul H.A.

2014-01-01

Abstract In this study, we target the hypoxia inducible factor-1 alpha (HIF-1-alpha) pathway by short hairpin RNA interference therapy targeting prolyl hydroxylase-2 (shPHD2). We use the minicircle (MC) vector technology as an alternative for conventional nonviral plasmid (PL) vectors in order to improve neovascularization after unilateral hindlimb ischemia in a murine model. Gene expression and transfection efficiency of MC and PL, both in vitro and in vivo, were assessed using bioluminescence imaging (BLI) and firefly luciferase (Luc) reporter gene. C57Bl6 mice underwent unilateral electrocoagulation of the femoral artery and gastrocnemic muscle injection with MC-shPHD2, PL-shPHD2, or phosphate-buffered saline (PBS) as control. Blood flow recovery was monitored using laser Doppler perfusion imaging, and collaterals were visualized by immunohistochemistry and angiography. MC-Luc showed a 4.6-fold higher in vitro BLI signal compared with PL-Luc. BLI signals in vivo were 4.3×105±3.3×105 (MC-Luc) versus 0.4×105±0.3×105 (PL-Luc) at day 28 (p=0.016). Compared with PL-shPHD2 or PBS, MC-shPHD2 significantly improved blood flow recovery, up to 50% from day 3 until day 14 after ischemia induction. MC-shPHD2 significantly increased collateral density and capillary density, as monitored by alpha-smooth muscle actin expression and CD31+ expression, respectively. Angiography data confirmed the histological findings. Significant downregulation of PHD2 mRNA levels by MC-shPHD2 was confirmed by quantitative polymerase chain reaction. Finally, Western blot analysis confirmed significantly higher levels of HIF-1-alpha protein by MC-shPHD2, compared with PL-shPHD2 and PBS. This study provides initial evidence of a new potential therapeutic approach for peripheral artery disease. The combination of HIF-1-alpha pathway targeting by shPHD2 with the robust nonviral MC plasmid improved postischemic neovascularization, making this approach a promising potential treatment option for critical limb ischemia. PMID:24090375

Effects of an adapted physical activity program on psychophysical health in elderly women.

PubMed

Battaglia, Giuseppe; Bellafiore, Marianna; Alesi, Marianna; Paoli, Antonio; Bianco, Antonino; Palma, Antonio

2016-01-01

Several studies have shown the positive effects of adapted physical activity (APA) on physical and mental health (MH) during the lifetime. The aim of this study was to assess the effectiveness of a specific APA intervention program in the improvement of the health-related quality of life (QOL) and functional condition of spine in elderly women. Thirty women were recruited from a senior center and randomly assigned to two groups: control group (CG; age: 69.69±7.94 years, height: 1.57±0.06 m, weight: 68.42±8.18 kg, body mass index [BMI]: 27.88±2.81) and trained group (TG; age: 68.35±6.04 years, height: 1.55±0.05 m, weight: 64.78±10.16 kg, BMI: 26.98±3.07). The APA program was conducted for 8 weeks, with two training sessions/week. CG did not perform any physical activity during the study. Spinal angles were evaluated by SpinalMouse(®) (Idiag, Volkerswill, Switzerland); health-related QOL was evaluated by SF-36 Health Survey, which assesses physical component summary (PCS-36), mental component summary (MCS-36), and eight subscales: physical functioning, role-physical, bodily pain, general health perception, role-emotional, social functioning, vitality, and MH. All measures were recorded before and after the experimental period. In TG, compared to CG, the two-way analysis of variance with repeated measures with Bonferroni post hoc test showed a relevant improvement in lumbar spinal angle (°) and in SF-36 outcomes after the intervention period. We showed a significant increase in physical functioning, bodily pain, and MH subscales and in PCS-36 and MCS-36 scores in TG compared to CG. In particular, from baseline to posttest, we found that in TG, the PCS-36 and MCS-36 scores increased by 13.20% and 11.64%, respectively. We believe that an 8-week APA intervention program is able to improve psychophysical heath in elderly people. During the aging process, a dynamic lifestyle, including regular physical activity, is a crucial factor for public and health care systems to improve QOL and physical fitness in aging people.

[Development of MEDUC-PG14 survey to assess postgraduate teaching in medical specialties].

PubMed

Pizarro, Margarita; Solís, Nancy; Rojas, Viviana; Díaz, Luis Antonio; Padilla, Oslando; Letelier, Luz María; Aizman, Andrés; Sarfatis, Alberto; Olivos, Trinidad; Soza, Alejandro; Delfino, Alejandro; Latorre, Gonzalo; Ivanovic-Zuvic, Danisa; Hoyl, Trinidad; Bitran, Marcela; Arab, Juan Pablo; Riquelme, Arnoldo

2015-08-01

Feedback is one of the most important tools to improve teaching in medical education. To develop an instrument to assess the performance of clinical postgraduate teachers in medical specialties. A qualitative methodology consisting in interviews and focus-groups followed by a quantitative methodology to generate consensus, was employed. After generating the instrument, psychometric tests were performed to assess the construct validity (factor analysis) and reliability (Cronbach’s alpha). Experts in medical education, teachers and residents of a medical school participated in interviews and focus groups. With this information, 26 categories (79 items) were proposed and reduced to 14 items (Likert scale 1-5) by an expert’s Delphi panel, generating the MEDUC-PG14 survey, which was answered by 123 residents from different programs of medical specialties. Construct validity was carried out. Factor analysis showed three domains: Teaching and evaluation, respectful behavior towards patients and health care team, and providing feedback. The global score was 4.46 ± 0.94 (89% of the maximum). One teachers’ strength, as evaluated by their residents was “respectful behavior” with 4.85 ± 0.42 (97% of the maximum). “Providing feedback” obtained 4.09 ± 1.0 points (81.8% of the maximum). MEDUC-PG14 survey had a Cronbach’s alpha coefficient of 0.947. MEDUC-PG14 survey is a useful and reliable guide for teacher evaluation in medical specialty programs. Also provides feedback to improve educational skills of postgraduate clinical teachers.

Preliminary Magnitude of Completeness Quantification of Improved BMKG Catalog (2008-2016) in Indonesian Region

NASA Astrophysics Data System (ADS)

Diantari, H. C.; Suryanto, W.; Anggraini, A.; Irnaka, T. M.; Susilanto, P.; Ngadmanto, D.

2018-03-01

We present a magnitude of completeness (Mc) quantification based on BMKG improved earthquake catalog which generated from Ina-TEWS seismograph network. The Mc quantification can help us determine the lowest magnitude which can be recorded perfectly as a function of space and time. We use the BMKG improved earthquake catalog from 2008 to 2016 which has been converted to moment magnitude (Mw) and declustered. The value of Mc is computed by determining the initial point of deviation patterns in Frequency Magnitude Distribution (FMD) chart following the Gutenberg-Richter equations. In the next step, we calculate the temporal variation of Mc and b-value using maximum likelihood method annually. We found that the Mc value is decreasing and produced a varying b-value. It indicates that the development of seismograph network from 2008 to 2016 can affect the value of Mc although it is not significant. We analyze temporal variation of Mc value, and correlate it with the spatial distribution of seismograph in Indonesia. The spatial distribution of seismograph installation shows that the western part of Indonesia has more dense seismograph compared to the eastern region. However, the eastern part of Indonesia has a high level of seismicity compared to the western region. Based upon the results, additional seismograph installation in the eastern part of Indonesia should be taken into consideration.

List of Antineoplastic and Other Hazardous Drugs in Healthcare Settings 2012

MedlinePlus

... inorganic arsenic compounds, which include the antineoplastic drug ar- senic trioxide [29 CFR 1910.1018; NIOSH 2004; ... an established safety program [McDiarmid et al. 1991; Ar- rington and McDiarmid 1993]. The criteria are prioritized ...

Quality Circles: An Innovative Program to Improve Military Hospitals

DTIC Science & Technology

1982-08-01

quality control. However, Dr. Kaoru Ishikawa is credited with starting the first "Quality Control Circles" and registering them with the Japanese Union of...McGregor and Abraham Maslow into a unique style of management. In 1962 Dr. Ishikawa , a professor at Tokyo University, developed the QC concept based on...RECOMMENDATIONS Conclusions The QC concept has come a long way since Dr. Ishikawa gave it birth in 1962. It has left an enviable record of success along its

Improved Understanding of Fenton-like Reactions for the In Situ Remediation of Contaminated Groundwater Including Treatment of Sorbed Contaminants and Destruction of DNAPLs

DTIC Science & Technology

2006-04-29

Dehalogenation of Chlorinated Methanes by Iron Metal.” Environ . Sci. Technol. 28, 2045-2053. McBride, M.B. Environmental Chemistry of Soils; Oxford Press: New...Oxidative Transformation of Triclosan and Chlorophene by Manganese Oxides. Environ . Sci. Technol. 2003, 37, 2421-2430 Zhang, Y., Crittenden, J.C...prepared under contract to the Department of Defense Strategic Environmental Research and Development Program (SERDP). The publication of this report does

Do medical complications impact long-term outcomes in prolonged disorders of consciousness?

PubMed

Estraneo, Anna; Loreto, Vincenzo; Masotta Psy, Orsola; Pascarella, Angelo; Trojano, Luigi

2018-05-25

to investigate medical complications (MC) occuring within 6 months post-injury in brain-injured patients with prolonged disorders of consciousness (DoC) and to evaluate impact of MC on mortality and long-term clinical outcomes. prospective observational cohort study. rehabilitation unit for acquired DoC. 194 patients with DoC (142 in vegetative state, 52 in minimally conscious state; traumatic etiology: 43, anoxic: 69, vascular: 82) consecutively admitted to a neurorehabilitation unit within 1-3 months after onset. not applicable. mortality and improvements in clinical diagnosis and functional disability level (assessed by Coma Recovery Scale-Revised and Disability Rating Scale) at 12, 24 and 36 months post-onset. within 6 months post-injury, more than 95% of patients (188/194) developed at least 1 MC and 73% of them (142) showed at least 1 severe MC. Respiratory and musculoskeletal-cutaneous MC were the most frequent, followed by endocrino-metabolic abnormalities. Follow-up, complete in 189/194 patients, showed that male sex and endocrine-metabolic MC were associated to higher risk for mortality at all timepoints. Older age, anoxic etiology, lower CRS-R total scores and diagnosis of vegetative state at study entry predicted no clinical and functional improvements at most timepoints, whereas epilepsy predicted no improvement in diagnosis at 24 months post-onset only. MC are very frequent in patients with DoC within at least 6 months after brain injury, regardless of clinical diagnosis, etiology and age. Endocrino-metabolic MC are independent predictors of mortality at all timepoints, whereas epilepsy predicted poor long-term outcome. Occurrence and severity of MC in patients with DoC call for long-term appropriate levels of care after the post-acute phase. Copyright © 2018. Published by Elsevier Inc.

Exploration of Epistemological Beliefs in a Summer Science Program for High Achieving Students(1)

NASA Astrophysics Data System (ADS)

Cormier, Sebastien; Raia, F.; Steinberg, R.

2006-12-01

We will describe changes in epistemology of students in a comprehensive summer science program for high achieving students at City College New York. The program focuses on having students participate in the process of scientific discovery using inquiry based activities such as the astronomy units from Physics by Inquiry(2). Multiple tools were used throughout the program to study student epistemological beliefs about science. We administered a Likert scale survey about how science is done as well as multiple content questions from which student beliefs were inferred. Instructor perspectives on student epistemologies are used in conjunction with these tools to study improvements and correlations between the different measures. (1) Supported in part by the National Science Foundation (2) Physics by Inquiry, L.C. McDermott, John Wiley & Sons, Inc., New York, 1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jensen, Michael; Kollias, Pavlos; Giangrande, Scott

The Mid-latitude Continental Convective Clouds Experiment (MC3E) took place from April 22 through June 6, 2011, centered at the ARM Southern Great Plains site (http://www.arm.gov/sites/sgp) in northcentral Oklahoma. MC3E was a collaborative effort between the ARM Climate Research Facility and the National Aeronautics and Space Administration’s (NASA’s) Global Precipitation Measurement (GPM) mission Ground Validation (GV) program. The campaign leveraged the largest ground-based observing infrastructure available in the central United States, including recent upgrades through the American Recovery and Reinvestment Act of 2009, combined with an extensive sounding array, remote sensing and in situ aircraft observations, and additional radar and inmore » situ precipitation instrumentation. The overarching goal of the campaign was to provide a three-dimensional characterization of convective clouds and precipitation for the purpose of improving the representation of convective lifecycle in atmospheric models and the reliability of satellite-based retrievals of precipitation.« less

Let Our Students Be Our Guides: McNair Scholars "Guide" Three Urban Teacher Educators on Meeting the Needs of Culturally Diverse Learners

ERIC Educational Resources Information Center

Jett, Christopher C.; McNeal Curry, Kezia; Vernon-Jackson, Sandra

2016-01-01

This case study examines the PreK-16 schooling experiences of nine McNair Post-Baccalaureate Achievement Program Scholars from a large, urban university in the southeast with respect to culturally relevant teaching. This study highlights the experiences of the McNair Scholars in an effort to assist educators in creating spaces that allow…

Naval Air Systems Command Mobile Facility Program

DTIC Science & Technology

2009-11-03

Julie Trossbach 301-757-3073 Database Manager – Emi McCutcheon 301-757- 8347 BFM – Michelle Moorman 301-757-8328 Comptroller Analyst – Kathy...Jamie McDonald (757) 444-1428 NAVAIR Mobile Facilities MFTool/Database AIR 6.7.6.2 Emi McCutcheon (301) 757-8347 NAVAIR Mobile Facilities Logistics...requirement for mobile trailer -type vans for peculiar jet aircraft maintenance – Needed dust free, temperature & humidity-controlled maintenance

View of Astronaut Jon McBride during Zero-G training

NASA Image and Video Library

1984-07-16

S84-37522 (18 July 1984) --- Astronaut Jon A. McBride, center, floats briefly aboard a NASA KC-135 aircraft during a flight designed as part of the training program for 41-G's seven crewmembers. McBride is pilot for that October 1984 flight. Marc Garneau, one of two payload specialists for the mission, is seated at right. Garneau represents the National Research Council of Canada.

CHAD Explorer - An Enhanced Web Application for CHAD

EPA Science Inventory

In 1999 the US Environmental Protection Agency (EPA) developed a Consolidated Human Activity Database (CHAD). CHAD has been used for various exposure modeling studies (McCurdy et al., 2000, Graham & McCurdy, 2004; McCurdy & Graham, 2003). Recently, CHAD has been improved and enha...

High-Performance and Traditional Multicrystalline Silicon: Comparing Gettering Responses and Lifetime-Limiting Defects

DOE Office of Scientific and Technical Information (OSTI.GOV)

Castellanos, Sergio; Ekstrom, Kai E.; Autruffe, Antoine

2016-05-01

In recent years, high-performance multicrystalline silicon (HPMC-Si) has emerged as an attractive alternative to traditional ingot-based multicrystalline silicon (mc-Si), with a similar cost structure but improved cell performance. Herein, we evaluate the gettering response of traditional mc-Si and HPMC-Si. Microanalytical techniques demonstrate that HPMC-Si and mc-Si share similar lifetime-limiting defect types but have different relative concentrations and distributions. HPMC-Si shows a substantial lifetime improvement after P-gettering compared with mc-Si, chiefly because of lower area fraction of dislocation-rich clusters. In both materials, the dislocation clusters and grain boundaries were associated with relatively higher interstitial iron point-defect concentrations after diffusion, which ismore » suggestive of dissolving metal-impurity precipitates. The relatively fewer dislocation clusters in HPMC-Si are shown to exhibit similar characteristics to those found in mc-Si. Given similar governing principles, a proxy to determine relative recombination activity of dislocation clusters developed for mc-Si is successfully transferred to HPMC-Si.« less

Performance of Improved Channel Allocation for Multicarrier CDMA with Adaptive Frequency Hopping and Multiuser Detection

DTIC Science & Technology

2008-08-29

resulting in much larger system capacity than for a non-adaptive MC direct-sequence ( DS )- CDMA system. This conclusion is confirmed for realistic fading...system capacity than for a non-adaptive MC direct-sequence ( DS )- CDMA system. This conclusion is confirmed for realistic fading channels with correlated...transmission method exploits both frequency and multiuser diversity and improves on non-adaptive MC DS - CDMA sys- tems in [6]. In this paper, we focus on the

Feeding a Mixture of Choline Forms to Lactating Dams Improves the Development of the Immune System in Sprague-Dawley Rat Offspring.

PubMed

Richard, Caroline; Lewis, Erin D; Goruk, Susan; Wadge, Emily; Curtis, Jonathan M; Jacobs, René L; Field, Catherine J

2017-06-02

Dietary choline is essential during lactation, but few studies have examined the implications of feeding a mixture of choline forms on immune function. This study investigates the impact of feeding lactating dams different mixtures of choline forms, similar to those in human diets, on the development and later immune function of suckled offspring. Sprague-Dawley lactating dams ( n = 6/diet) were randomized to consume one of three diets, containing 1 g/kg choline: Control (100% free choline (FC)), Mixed Choline (MC: 50% phosphatidylcholine (PC), 25% FC, 25% glycerophosphocholine (GPC)), or High GPC (HGPC: 75% GPC, 12.5% PC, 12.5% FC). At weaning, female pups ( n = 2/dam) were fed the Control diet until 10 weeks. At 3 weeks, MC and HGPC pups were heavier and their splenocytes had a higher proportion of helper T cells expressing CD25 and CD28 and produced less interferon gamma (IFN-γ) and tumor-necrosis factor-α (TNF-α) after Concanavalin A stimulation vs. Control pups ( p < 0.05). At 10 weeks, MC and HGPC offspring had a lower proportion of macrophages and dendritic cells and produced less interleukin (IL)-1β but more IL-10 after lipopolysaccharide stimulation vs. Control pups ( p < 0.05). In summary, feeding mixed choline diets during lactation improved T cell phenotype/function at the end of suckling and programmed a less inflammatory response later in life.

Feeding a Mixture of Choline Forms to Lactating Dams Improves the Development of the Immune System in Sprague-Dawley Rat Offspring

PubMed Central

Richard, Caroline; Lewis, Erin D.; Goruk, Susan; Wadge, Emily; Curtis, Jonathan M.; Jacobs, René L.; Field, Catherine J.

2017-01-01

Dietary choline is essential during lactation, but few studies have examined the implications of feeding a mixture of choline forms on immune function. This study investigates the impact of feeding lactating dams different mixtures of choline forms, similar to those in human diets, on the development and later immune function of suckled offspring. Sprague-Dawley lactating dams (n = 6/diet) were randomized to consume one of three diets, containing 1 g/kg choline: Control (100% free choline (FC)), Mixed Choline (MC: 50% phosphatidylcholine (PC), 25% FC, 25% glycerophosphocholine (GPC)), or High GPC (HGPC: 75% GPC, 12.5% PC, 12.5% FC). At weaning, female pups (n = 2/dam) were fed the Control diet until 10 weeks. At 3 weeks, MC and HGPC pups were heavier and their splenocytes had a higher proportion of helper T cells expressing CD25 and CD28 and produced less interferon gamma (IFN-γ) and tumor-necrosis factor-α (TNF-α) after Concanavalin A stimulation vs. Control pups (p < 0.05). At 10 weeks, MC and HGPC offspring had a lower proportion of macrophages and dendritic cells and produced less interleukin (IL)-1β but more IL-10 after lipopolysaccharide stimulation vs. Control pups (p < 0.05). In summary, feeding mixed choline diets during lactation improved T cell phenotype/function at the end of suckling and programmed a less inflammatory response later in life. PMID:28574475

Worta McCaskill-Stevens, MD, MS | Division of Cancer Prevention

Cancer.gov

Dr. Worta McCaskill-Stevens is a medical oncologist and Chief of the Community Oncology and Prevention Trials Research Group, which houses the NCI Community Oncology Research Program (NCORP), a community-based clinical trials network launched in 2014. |

A Moderate Redshift Supernova Search Program

NASA Astrophysics Data System (ADS)

Adams, M. T.; Wheeler, J. C.; Ward, M.; Wren, W. R.; Schmidt, B. P.

1995-12-01

We report on a recently initiated supernova (SN) search program using the McDonald Observatory 0.76m telescope and Prime Focus Camera (PFC). This SN search program takes advantage of the PFC's 42.6 x 42.6 arcmin FOV to survey moderate redshift Abell clusters in single Kron-Cousins R-band images. Our scientific goal is to discover and provide quality BVRI photometric follow-up, to R \\ +21, for a significant SNe sample at 0.03 < z < 0.15. These data will constrain SNe progenitor models and calibrate SN luminosity, color and light curve characteristics, as a function of host galaxy type, increasing our understanding of the utility of SNe as "calibrated candles" and cosmological model probes. The McDonald SNe provide an important link between the local discoveries of the LBL Automated Nearby SN Search (Pennypacker et al 1995, Aiguiblava NATO ASI Proceedings, in preparation), and the very distant SNe found by the LBL/UC Berkeley group (Perlmutter et al 1995, ApJ, 440, L41), and the High Redshift SN Search Team (Schmidt et al 1995, Aiguiblava NATO ASI Proceedings). The McDonald SN search program includes a sample of the Abell clusters used by Lauer and Postman (1994, ApJ, 425, 418) to analyze Local Group motion. SNe discovered in these clusters contribute to the resolution of the Local Group motion controversy. We present an overview of the McDonald Observatory supernova search program, and discuss recent results.

26 CFR 1.818-8 - Special rules relating to consolidated returns and certain capital losses.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Special rules relating to consolidated returns... Special rules relating to consolidated returns and certain capital losses. Section 818(g) provides that, in the case of a life insurance company filing or required to file a consolidated return under...

MC-TESTER: a universal tool for comparisons of Monte Carlo predictions for particle decays in high energy physics

NASA Astrophysics Data System (ADS)

Golonka, P.; Pierzchała, T.; Waş, Z.

2004-02-01

Theoretical predictions in high energy physics are routinely provided in the form of Monte Carlo generators. Comparisons of predictions from different programs and/or different initialization set-ups are often necessary. MC-TESTER can be used for such tests of decays of intermediate states (particles or resonances) in a semi-automated way. Our test consists of two steps. Different Monte Carlo programs are run; events with decays of a chosen particle are searched, decay trees are analyzed and appropriate information is stored. Then, at the analysis step, a list of all found decay modes is defined and branching ratios are calculated for both runs. Histograms of all scalar Lorentz-invariant masses constructed from the decay products are plotted and compared for each decay mode found in both runs. For each plot a measure of the difference of the distributions is calculated and its maximal value over all histograms for each decay channel is printed in a summary table. As an example of MC-TESTER application, we include a test with the τ lepton decay Monte Carlo generators, TAUOLA and PYTHIA. The HEPEVT (or LUJETS) common block is used as exclusive source of information on the generated events. Program summaryTitle of the program:MC-TESTER, version 1.1 Catalogue identifier: ADSM Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADSM Program obtainable from: CPC Program Library, Queen's University of Belfast, N. Ireland Computer: PC, two Intel Xeon 2.0 GHz processors, 512MB RAM Operating system: Linux Red Hat 6.1, 7.2, and also 8.0 Programming language used:C++, FORTRAN77: gcc 2.96 or 2.95.2 (also 3.2) compiler suite with g++ and g77 Size of the package: 7.3 MB directory including example programs (2 MB compressed distribution archive), without ROOT libraries (additional 43 MB). No. of bytes in distributed program, including test data, etc.: 2 024 425 Distribution format: tar gzip file Additional disk space required: Depends on the analyzed particle: 40 MB in the case of τ lepton decays (30 decay channels, 594 histograms, 82-pages booklet). Keywords: particle physics, decay simulation, Monte Carlo methods, invariant mass distributions, programs comparison Nature of the physical problem: The decays of individual particles are well defined modules of a typical Monte Carlo program chain in high energy physics. A fast, semi-automatic way of comparing results from different programs is often desirable, for the development of new programs, to check correctness of the installations or for discussion of uncertainties. Method of solution: A typical HEP Monte Carlo program stores the generated events in the event records such as HEPEVT or PYJETS. MC-TESTER scans, event by event, the contents of the record and searches for the decays of the particle under study. The list of the found decay modes is successively incremented and histograms of all invariant masses which can be calculated from the momenta of the particle decay products are defined and filled. The outputs from the two runs of distinct programs can be later compared. A booklet of comparisons is created: for every decay channel, all histograms present in the two outputs are plotted and parameter quantifying shape difference is calculated. Its maximum over every decay channel is printed in the summary table. Restrictions on the complexity of the problem: For a list of limitations see Section 6. Typical running time: Varies substantially with the analyzed decay particle. On a PC/Linux with 2.0 GHz processors MC-TESTER increases the run time of the τ-lepton Monte Carlo program TAUOLA by 4.0 seconds for every 100 000 analyzed events (generation itself takes 26 seconds). The analysis step takes 13 seconds; ? processing takes additionally 10 seconds. Generation step runs may be executed simultaneously on multi-processor machines. Accessibility: web page: http://cern.ch/Piotr.Golonka/MC/MC-TESTER e-mails: Piotr.Golonka@CERN.CH, T.Pierzchala@friend.phys.us.edu.pl, Zbigniew.Was@CERN.CH.

Gastro-Resistant Insulin Receptor-Binding Peptide from Momordica charantia Improved the Glucose Tolerance in Streptozotocin-Induced Diabetic Mice via Insulin Receptor Signaling Pathway.

PubMed

Lo, Hsin-Yi; Li, Chia-Cheng; Chen, Feng-Yuan; Chen, Jaw-Chyun; Hsiang, Chien-Yun; Ho, Tin-Yun

2017-10-25

Momordica charantia is a commonly used food and has been used for the management of diabetes. Our previous study has identified an insulin receptor (IR)-binding protein (mcIRBP) from Momordica charantia. Here we identified the gastro-resistant hypoglycemic bioactive peptides from protease-digested mcIRBP. By in vitro digestion and IR kinase activity assay, we found that a 9-amino-acid-residue peptide, mcIRBP-9, was a gastro-resistant peptide that enhanced IR kinase activities. mcIRBP-9 activated IR signaling transduction pathway, which resulted in the phosphorylation of IR, the translocation of glucose transporter 4, and the uptake of glucose in cells. Intraperitoneal and oral administration of mcIRBP-9 stimulated the glucose clearance by 30.91 ± 0.39% and 32.09 ± 0.38%, respectively, in streptozotocin-induced diabetic mice. Moreover, a pilot study showed that daily ingestion of mcIRBP-9 for 30 days decreased the fasting blood glucose levels and glycated hemoglobin (HbA1c) levels by 23.62 ± 6.14% and 24.06 ± 1.53%, respectively. In conclusion, mcIRBP-9 is a unique gastro-resistant bioactive peptide generated after the digestion of mcIRBP. Furthermore, oral administration of mcIRBP-9 improves both the glucose tolerance and the HbA1c levels in diabetic mice via targeting IR signaling transduction pathway.

Installation Restoration Program. Phase 1. Records Search, McGuire AFB, New Jersey

DTIC Science & Technology

1982-11-01

Raritan- Magothy System * 3.12 Log of Base Well OD" 3-23 3.13 Well no. 1 at McGuire Missile Site 3-25 3.14 Base Well Locations 3-26 3.15 Surface Water...in the Potomac-Raritan- Magothy outcrop area has been published. This is not expected to impact base water quality in the near term. o Flooding is not a...Potamac-Raritan- Magothy System (PRM) 3-13 FIGURE 3.7 McGUIRE AFB STANDARD LOG OF McGUIRE PENETRATION. TEST MISSILE SITE I TEST BORING 46 21 DEPTH BELOW

Final Environmental Assessment: Solar Panel Systems at Joint Base McGuire-Dix-Lakehurst New Jersey

DTIC Science & Technology

2012-03-01

FINAL ENVIRONMENTAL ASSESSMENT Solar Panel Systems at Joint Base McGuire-Dix-Lakehurst, New Jersey MARCH 2012...Final Environmental Assessment : Solar Panel Systems at Joint Base McGuire-Dix-Lakehurst New Jersey 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM...unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 Purpose Finding of No Significant Impact (FONSI) Environmental Assessment (EA

Development of a Comprehensive Base-Level Environmental Training Program for Total Environmental Compliance

DTIC Science & Technology

1994-09-01

Business Managers. Ed. Betty Seldner. San Francisco : McGraw Hill, Inc., 1994 11. Gunderson, John. "Federal Facilities Compliance Act," in Environmental...Decision Making for Engineering and Business Managers. Ed. Betty Seldner. San Francisco : McGraw Hill, Inc., 1994 105 12. Heyman, Glenn. "The Role and...San Francisco . McGraw Hill, Inc., 1994 13- Hill, Chuck. Environmental Oversight Branch, Headquarters Air Combat Command. Personal Correspondence

ProMC: Input-output data format for HEP applications using varint encoding

NASA Astrophysics Data System (ADS)

Chekanov, S. V.; May, E.; Strand, K.; Van Gemmeren, P.

2014-10-01

A new data format for Monte Carlo (MC) events, or any structural data, including experimental data, is discussed. The format is designed to store data in a compact binary form using variable-size integer encoding as implemented in the Google's Protocol Buffers package. This approach is implemented in the PROMC library which produces smaller file sizes for MC records compared to the existing input-output libraries used in high-energy physics (HEP). Other important features of the proposed format are a separation of abstract data layouts from concrete programming implementations, self-description and random access. Data stored in PROMC files can be written, read and manipulated in a number of programming languages, such C++, JAVA, FORTRAN and PYTHON.

McDonnell Model XV-1 Convertiplane in the Ames 40x80 Foot Wind Tunnel.

NASA Image and Video Library

1954-05-17

Foreword, front view of McDonnell Model XV-1 Convertiplane in the Ames 40x80 Foot Wind Tunnel. The McDonnell XV-1 was an experimental compound gyroplane developed for a joint research program between the United States Air Force and the United States Army to explore technologies to develop an aircraft that could take off and land like a helicopter but fly at faster airspeeds, similar to a conventional airplane. The XV-1 would reach a speed of 200 mph (322 km/h), faster than any previous rotorcraft, but the program was terminated due to the tip-jet noise and complexity of the technology which gave only a modest gain in performance.

Making the Grade: Challenges and Successes in Providing Educational Opportunities for Children and Youth in Homeless Situations. Bridging the Gap between Home and School. A Position Document.

ERIC Educational Resources Information Center

National Association of State Coordinators for the Education of Homeless Children and Youth.

Profiles of the 1995-96 implementation of the Stewart B. McKinney Act's Education for Homeless Children and Youth (EHCY) Programs in 37 states are presented in this document. In these 37 states, at least 173,082 homeless children and youth were served through programs funded by the McKinney Act, and at least 465 local education agencies received…

Defense AT and L Magazine. Vol. 42, no. 5, September-October 2013

DTIC Science & Technology

2013-09-01

McFarland DAU Acting President Dr. James McMichael DAU Chief of Staff Joseph Johnson Director, DAU Operations Support Group Leo Filipowicz Director...after more than 35 years in federal service, Dryden turned over lead of the Cost Consciousness team to Paul Peters, Principal Deputy Assistant...2 DMS Mod) on May 3. Dana W. Whalley relieved George K. Francois as program manager for the Space Fence Program on May 22. Col. Jeffrey C. Sobel

Precision Strike 2009 Summer Forum: Affordable Precision Munitions-The Reliable Choice for Modern Battle

DTIC Science & Technology

2009-06-10

Sponsored by: General Dynamics-OTS) 0800 SUMMER FORUM WELCOME: Andy McHugh —Chairman of the Board, Precision Strike Association 0810...Andy McHugh , Chairman of the Board, PSA ArmAments technology Fire Power Forum committee PSA Programs Chair: Ginny Sniegon PSA Programs Vice-Chair...Business For G-20 Meeting: Russia’s Strategic Resource Grab • BY DANIEL MCGROARTY Posted 4/1/2009 • Metals conglomerate Norilsk Nickel owns the United

Metabolite-cycled STEAM and semi-LASER localization for MR spectroscopy of the human brain at 9.4T.

PubMed

Giapitzakis, Ioannis-Angelos; Shao, Tingting; Avdievich, Nikolai; Mekle, Ralf; Kreis, Roland; Henning, Anke

2018-04-01

Metabolite cycling (MC) is an MRS technique for the simultaneous acquisition of water and metabolite spectra that avoids chemical exchange saturation transfer effects and for which water may serve as a reference signal or contain additional information in functional or diffusion studies. Here, MC was developed for human investigations at ultrahigh field. MC-STEAM and MC-semi-LASER are introduced at 9.4T with an optimized inversion pulse and elaborate coil setup. Experimental and simulation results are given for the implementation of adiabatic inversion pulses for MC. The two techniques are compared, and the effect of frequency and phase correction based on the MC water spectra is evaluated. Finally, absolute quantification of metabolites is performed. The proposed coil configuration results in a maximum B1 + of 48 μΤ in a voxel within the occipital lobe. Frequency and phase correction of single acquisitions improve signal-to-noise ratio (SNR) and linewidth, leading to high-resolution spectra. The improvement of SNR of N-acetylaspartate (SNR NAA ) for frequency aligned data, acquired with MC-STEAM and MC-semi-LASER, are 37% and 30%, respectively (P < 0.05). Moreover, a doubling of the SNR NAA for MC-semi-LASER in comparison with MC-STEAM is observed (P < 0.05). Concentration levels for 18 metabolites from the human occipital lobe are reported, as acquired with both MC-STEAM and MC-semi-LASER. This work introduces a novel methodology for single-voxel MRS on a 9.4T whole-body scanner and highlights the advantages of semi-LASER compared to STEAM in terms of excitation profile. In comparison with MC-STEAM, MC-semi-LASER yields spectra with higher SNR. Magn Reson Med 79:1841-1850, 2018. © 2017 International Society for Magnetic Resonance in Medicine. © 2017 International Society for Magnetic Resonance in Medicine.

Update on the College of American Pathologists Experience With High-Risk Human Papillomavirus Proficiency Testing for Cytology.

PubMed

Ghofrani, Mohiedean; Zhao, Chengquan; Davey, Diane D; Fan, Fang; Husain, Mujtaba; Laser, Alice; Ocal, Idris T; Shen, Rulong Z; Goodrich, Kelly; Souers, Rhona J; Crothers, Barbara A

2016-12-01

- Since 2008, the College of American Pathologists has provided the human papillomavirus for cytology laboratories (CHPV) proficiency testing program to help laboratories meet the requirements of the Clinical Laboratory Improvement Amendments of 1988. - To provide an update on trends in proficiency testing performance in the College of American Pathologists CHPV program during the 4-year period from 2011 through 2014 and to compare those trends with the preceding first 3 years of the program. - Responses of laboratories participating in the CHPV program from 2011 through 2014 were analyzed using a nonlinear mixed model to compare different combinations of testing medium and platform. - In total, 818 laboratories participated in the CHPV program at least once during the 4 years, with participation increasing during the study period. Concordance of participant responses with the target result was more than 98% (38 280 of 38 892). Overall performance with all 3 testing media-ThinPrep (Hologic, Bedford, Massachusetts), SurePath (Becton, Dickinson and Company, Franklin Lakes, New Jersey), or Digene (Qiagen, Valencia, California)-was equivalent (P = .51), and all 4 US Food and Drug Administration (FDA)-approved platforms-Hybrid Capture 2 (Qiagen), Cervista (Hologic), Aptima (Hologic), and cobas (Roche Molecular Systems, Pleasanton, California)-outperformed laboratory-developed tests, unspecified commercial kits, and other (noncommercial) methods in ThinPrep medium (P < .001). However, certain off-label combinations of platform and medium, most notably Cervista with SurePath, demonstrated suboptimal performance (P < .001). - Laboratories demonstrated proficiency in using various combinations of testing media and platforms offered in the CHPV program, with statistically significant performance differences in certain combinations. These observations may be relevant in the current discussions about FDA oversight of laboratory-developed tests.

The welfare impact of Medicare HMOs.

PubMed

Town, Robert; Liu, Su

2003-01-01

We estimate the welfare associated with the Medicare HMO program, now known as Medicare+Choice (M+C). We find that the creation of the M+C program resulted in approximately $15.6 billion in consumer surplus and $52 billion in profits from 1993 to 2000 (in 2000 dollars). This program most likely generated significant net social welfare. However, we find that consumer surplus is geographically unevenly distributed. Prescription drug coverage accounts for approximately 45% of the estimated consumer surplus for 2000. Consumer surplus increases in the number of plans in a county, and most of the increase in welfare is due to increased premium competition.

Monte Carlo simulations to replace film dosimetry in IMRT verification.

PubMed

Goetzfried, Thomas; Rickhey, Mark; Treutwein, Marius; Koelbl, Oliver; Bogner, Ludwig

2011-01-01

Patient-specific verification of intensity-modulated radiation therapy (IMRT) plans can be done by dosimetric measurements or by independent dose or monitor unit calculations. The aim of this study was the clinical evaluation of IMRT verification based on a fast Monte Carlo (MC) program with regard to possible benefits compared to commonly used film dosimetry. 25 head-and-neck IMRT plans were recalculated by a pencil beam based treatment planning system (TPS) using an appropriate quality assurance (QA) phantom. All plans were verified both by film and diode dosimetry and compared to MC simulations. The irradiated films, the results of diode measurements and the computed dose distributions were evaluated, and the data were compared on the basis of gamma maps and dose-difference histograms. Average deviations in the high-dose region between diode measurements and point dose calculations performed with the TPS and MC program were 0.7 ± 2.7% and 1.2 ± 3.1%, respectively. For film measurements, the mean gamma values with 3% dose difference and 3mm distance-to-agreement were 0.74 ± 0.28 (TPS as reference) with dose deviations up to 10%. Corresponding values were significantly reduced to 0.34 ± 0.09 for MC dose calculation. The total time needed for both verification procedures is comparable, however, by far less labor intensive in the case of MC simulations. The presented study showed that independent dose calculation verification of IMRT plans with a fast MC program has the potential to eclipse film dosimetry more and more in the near future. Thus, the linac-specific QA part will necessarily become more important. In combination with MC simulations and due to the simple set-up, point-dose measurements for dosimetric plausibility checks are recommended at least in the IMRT introduction phase. Copyright © 2010. Published by Elsevier GmbH.

Motivational Interviewing as an Intervention for At-Risk Couples.

ERIC Educational Resources Information Center

Cordova, James V.; Warren, Lisa Zepeda; Gee, Christina B.

2001-01-01

Thirty-one couples participated in the Marriage Checkup (MC), a pilot, motivational interviewing intervention for at-risk couples. Marital satisfaction improved significantly from pre- to post-checkup and remained improved at one month follow up. Although not addressing the efficacy of MC, this study supports its validity as an indicative…

Simultaneous effect of initial moisture content and airflow rate on biodrying of sewage sludge.

PubMed

Huiliñir, Cesar; Villegas, Manuel

2015-10-01

The simultaneous effect of initial moisture content (initial Mc) and air-flow rate (AFR) on biodrying performance was evaluated. For the study, a 3(2) factorial design, whose factors were AFR (1, 2 and 3 L/min kg(TS)) and initial Mc (59, 68 and 78% w.b.), was used. Using energy and water mass balance the main routes of water removal, energy use and efficiencies were determined. The results show that initial Mc has a stronger effect on the biodrying than the AFR, affecting the air outlet temperature and improving the water removal, with higher maximum temperatures obtained around 68% and the lowest maximum matrix temperature obtained at initial Mc = 78%.Through the water mass balance it was found that the main mechanism for water removal was the aeration, with higher water removal at intermediate initial Mc (68%) and high AFR (3 L/min kg(TS)). The energy balance indicated that bioreaction is the main energy source for water evaporation, with higher energy produced at intermediate initial Mc (68%). Finally, it was found that low values of initial Mc (59%) improve biodrying efficiency. Copyright © 2015 Elsevier Ltd. All rights reserved.

Patient navigation to improve breast cancer screening in Bosnian refugees and immigrants.

PubMed

Percac-Lima, Sanja; Milosavljevic, Bosiljka; Oo, Sarah Abernethy; Marable, Danelle; Bond, Barbara

2012-08-01

Refugee women have low breast cancer screening rates. This study highlights the culturally competent implementation and reports the outcomes of a breast cancer screening patient navigation program for refuge/immigrant women from Bosnia. Refugees/immigrant women from Bosnia age 40-79 were contacted by a Serbo-Croatian speaking patient navigator who addressed patient-reported barriers to breast cancer screening and, using individually tailored interventions, helped women obtain screening. The proportion of women up-to-date for mammography was compared at baseline and after 1-year using McNemar's Chi-Square test. 91 Serbo-Croatian speaking women were eligible for mammography screening. At baseline, 44.0% of women had a mammogram within the previous year, with the proportion increasing to 67.0% after 1-year (P = 0.001). A culturally-tailored, language-concordant navigator program designed to overcome specific barriers to breast cancer screening can significantly improve mammography rates in refugees/immigrants.

Comprehensive Outpatient Rehabilitation Program: Hospital-Based Stroke Outpatient Rehabilitation.

PubMed

Rice, Danielle; Janzen, Shannon; McIntyre, Amanda; Vermeer, Julianne; Britt, Eileen; Teasell, Robert

2016-05-01

Few studies have considered the effectiveness of outpatient rehabilitation programs for stroke patients. The objective of this study was to assess the effectiveness of a hospital-based interdisciplinary outpatient stroke rehabilitation program with respect to physical functioning, mobility, and balance. The Comprehensive Outpatient Rehabilitation Program provides a hospital-based interdisciplinary approach to stroke rehabilitation in Southwestern Ontario. Outcome measures from physiotherapy and occupational therapy sessions were available at intake and discharge from the program. A series of paired sample t-tests were performed to assess patient changes between time points for each outcome measure. A total of 271 patients met the inclusion criteria for analysis (56.1% male; mean age = 62.9 ± 13.9 years). Significant improvements were found between admission and discharge for the Functional Independence Measure, grip strength, Chedoke-McMaster Stroke Assessment, two-minute walk test, maximum walk test, Timed Up and Go, Berg Balance Scale, and one-legged stance (P < .003 for all). The findings indicate that an interdisciplinary rehabilitation program was effective at improving the physical functioning, mobility, and balance of individuals after a stroke. A hospital-based, stroke-specific rehabilitation program should be considered when patients continue to experience deficits after inpatient rehabilitation. Copyright © 2016 National Stroke Association. Published by Elsevier Inc. All rights reserved.

KSC-00pp0239

NASA Image and Video Library

2000-02-16

Mack McKinney (left), chief, Programs Resources Management, and Delores Abraham (right), with the Astronaut office, flank one of the posters decorating the Early Space Exploration Conference Center at the KSC Visitor Complex for the 2000 African American History Month Celebration Luncheon. McKinney is chairperson for the event

KSC00pp0239

NASA Image and Video Library

2000-02-16

Mack McKinney (left), chief, Programs Resources Management, and Delores Abraham (right), with the Astronaut office, flank one of the posters decorating the Early Space Exploration Conference Center at the KSC Visitor Complex for the 2000 African American History Month Celebration Luncheon. McKinney is chairperson for the event

Cooking Up a Storm.

ERIC Educational Resources Information Center

Crafts, Peter

1983-01-01

Minuteman Vocational Technical School in Lexington, Massachusetts leases school space to McDonald's for a restaurant which also serves as a food service laboratory for students in the culinary arts hospitality management program. The school has also benefited from the renovation of its facilities by McDonald's. (SK)

Optimization of land use of agricultural farms in Sumedang regency by using linear programming models

NASA Astrophysics Data System (ADS)

Zenis, F. M.; Supian, S.; Lesmana, E.

2018-03-01

Land is one of the most important assets for farmers in Sumedang Regency. Therefore, agricultural land should be used optimally. This study aims to obtain the optimal land use composition in order to obtain maximum income. The optimization method used in this research is Linear Programming Models. Based on the results of the analysis, the composition of land use for rice area of 135.314 hectares, corn area of 11.798 hectares, soy area of 2.290 hectares, and peanuts of 2.818 hectares with the value of farmers income of IDR 2.682.020.000.000,-/year. The results of this analysis can be used as a consideration in decisions making about cropping patterns by farmers.

John B. McKay after X-15 flight #3-27-44

NASA Image and Video Library

1964-03-13

John B. McKay was one of the first pilots assigned to the X-15 flight research program at NASA's Flight Research Center, Edwards, Calif. As a civilian research pilot and aeronautical engineer, he made 30 flights in X-15s from October 28, 1960, until September 8, 1966. His peak altitude was 295,600 feet, and his highest speed was 3863 mph (Mach 5.64). McKay was with the NACA and NASA from February 8,1951 until October 5, 1971 and specialized in high-speed flight research programs. He began as an NACA intern, but assumed pilot status on July 11, 1952. In addition to the X-l5, he flew such experimental aircraft as the D-558-1, D-558-2, X-lB, and the X-lE. He has also served as a research pilot on flight programs involving the F-100, F-102, F-104, and the F-107. Born on December 8, 1922, in Portsmouth, Va., McKay graduated from Virginia Polytechnic Institute in 195O with a Bachelor of Science degree in Aeronautical Engineering. During World War II he served as a Navy pilot in the Pacific Theater, earning the Air Medal and Two Clusters, and a Presidential Unit Citation. McKay wrote several technical papers, and was a member of the American Institute of Aeronautics and Astronautics, as well as the Society of Experimental Test Pilots. He passed away on April 27, 1975.

Targeting the 5T4 oncofetal glycoprotein with an antibody drug conjugate (A1mcMMAF) improves survival in patient-derived xenograft models of acute lymphoblastic leukemia.

PubMed

McGinn, Owen J; Krishnan, Shekhar; Bourquin, Jean-Pierre; Sapra, Puja; Dempsey, Clare; Saha, Vaskar; Stern, Peter L

2017-06-01

Outcome in childhood acute lymphoblastic leukemia is prognosticated from levels of minimal residual disease after remission induction therapy. Higher levels of minimal residual disease are associated with inferior results even with intensification of therapy, thus suggesting that identification and targeting of minimal residual disease cells could be a therapeutic strategy. Here we identify high expression of 5T4 in subclonal populations of patient-derived xenografts from patients with high, post-induction levels of minimal residual disease. 5T4-positive cells showed preferential ability to overcome the NOD- scid IL2Rγ null mouse xenograft barrier, migrated in vitro on a CXCL12 gradient, preferentially localized to bone marrow in vivo and displayed the ability to reconstitute the original clonal composition on limited dilution engraftment. Treatment with A1mcMMAF (a 5T4-antibody drug conjugate) significantly improved survival without overt toxicity in mice engrafted with a 5T4-positive acute lymphoblastic leukemia cell line. Mice engrafted with 5T4-positive patient-derived xenograft cells were treated with combination chemotherapy or dexamethasone alone and then given A1mcMMAF in the minimal residual disease setting. Combination chemotherapy was toxic to NOD- scid IL2Rγ null mice. While dexamethasone or A1mcMMAF alone improved outcomes, the sequential administration of dexamethasone and A1mcMMAF significantly improved survival ( P =0.0006) over either monotherapy. These data show that specifically targeting minimal residual disease cells improved outcomes and support further investigation of A1mcMMAF in patients with high-risk B-cell precursor acute lymphoblastic leukemia identified by 5T4 expression at diagnosis. Copyright© Ferrata Storti Foundation.

Targeting the 5T4 oncofetal glycoprotein with an antibody drug conjugate (A1mcMMAF) improves survival in patient-derived xenograft models of acute lymphoblastic leukemia

PubMed Central

McGinn, Owen J.; Krishnan, Shekhar; Bourquin, Jean-Pierre; Sapra, Puja; Dempsey, Clare; Saha, Vaskar; Stern, Peter L.

2017-01-01

Outcome in childhood acute lymphoblastic leukemia is prognosticated from levels of minimal residual disease after remission induction therapy. Higher levels of minimal residual disease are associated with inferior results even with intensification of therapy, thus suggesting that identification and targeting of minimal residual disease cells could be a therapeutic strategy. Here we identify high expression of 5T4 in subclonal populations of patient-derived xenografts from patients with high, post-induction levels of minimal residual disease. 5T4-positive cells showed preferential ability to overcome the NOD-scidIL2Rγnull mouse xenograft barrier, migrated in vitro on a CXCL12 gradient, preferentially localized to bone marrow in vivo and displayed the ability to reconstitute the original clonal composition on limited dilution engraftment. Treatment with A1mcMMAF (a 5T4-antibody drug conjugate) significantly improved survival without overt toxicity in mice engrafted with a 5T4-positive acute lymphoblastic leukemia cell line. Mice engrafted with 5T4-positive patient-derived xenograft cells were treated with combination chemotherapy or dexamethasone alone and then given A1mcMMAF in the minimal residual disease setting. Combination chemotherapy was toxic to NOD-scidIL2Rγnull mice. While dexamethasone or A1mcMMAF alone improved outcomes, the sequential administration of dexamethasone and A1mcMMAF significantly improved survival (P=0.0006) over either monotherapy. These data show that specifically targeting minimal residual disease cells improved outcomes and support further investigation of A1mcMMAF in patients with high-risk B-cell precursor acute lymphoblastic leukemia identified by 5T4 expression at diagnosis. PMID:28341731

A multidimensional education program at substance dependence treatment centers improves patient knowledge and hepatitis C care.

PubMed

Marinho, Rui Tato; Costa, António; Pires, Teodomiro; Raposo, Helena; Vasconcelos, Carlos; Polónia, Cristina; Borges, Joaquim; Soares, Mariana; Vilar, Graça; Nogueira, Ana Maria

2016-10-12

HCV treatment among people who inject drugs (PWID) is low. Education programs may be suitable strategies to improve patients' knowledge about their condition and to overcome barriers to access treatment. The Health Educational Program (HEP) consisted of patient workshops and educational videos and leaflets, and healthcare professionals' workshops. HEP was implemented at seven substance dependence treatment centers (STDC) in Portugal. The study comprised two cross-sectional evaluations conducted before and after HEP. At both evaluations, adult patients with confirmed HCV diagnosis and registered in the STDC were consecutively included. For patients that completed both evaluations, the overall knowledge score were calculated and compared with McNemar test. Linear regression modelling was used to evaluate factors associated with baseline knowledge. Rates of referral and attendance to referral specialist, treatment proposal, initiation and retention at both evaluations were also compared with McNemar test. Overall, 504 patients with chronic hepatitis C were included: 78 % male, mean age 42.3 ± 6.6 years, 14 % school education ≤ 4 years, disease duration 11.0 ± 6.0 years and 26 % HIV co-infected. A higher baseline knowledge was independently associated with educational level ≥ 10 years (regression coefficient [B] =15.13, p < 0.001), current use of intravenous drugs (B = 7.99, p = 0.038), previous referral for treatment (B = 4.26, p = 0.008) and previous HCV treatment (B = 5.40, p = 0.003). Following HEP, mean knowledge score increased from 69 % to 79 % (p < 0.001). The rate of patient referral to a liver specialist increased from 56.2 % to 67.5 % (p < 0.001). An HEP conducted at STDCs improved significantly patient knowledge about hepatitis C, even among patients with a high baseline knowledge. The HEP has also increased the rate of referral to the liver specialist and showed a great potential to support healthcare professionals in managing HCV. Education programs may promote treatment access among PWID, a population that represents the majority of HCV infected patients.

Gulf Coast geopressured-geothermal program summary report compilation. Volume 2-B: Resource description, program history, wells tested, university and company based research, site restoration

DOE Office of Scientific and Technical Information (OSTI.GOV)

John, C.J.; Maciasz, G.; Harder, B.J.

1998-06-01

The US Department of Energy established a geopressured-geothermal energy program in the mid 1970`s as one response to America`s need to develop alternate energy resources in view of the increasing dependence on imported fossil fuel energy. This program continued for 17 years and approximately two hundred million dollars were expended for various types of research and well testing to thoroughly investigate this alternative energy source. This volume describes the following studies: Design well program; LaFourche Crossing; MG-T/DOE Amoco Fee No. 1 (Sweet Lake); Environmental monitoring at Sweet Lake; Air quality; Water quality; Microseismic monitoring; Subsidence; Dow/DOE L.R. Sweezy No. 1more » well; Reservoir testing; Environmental monitoring at Parcperdue; Air monitoring; Water runoff; Groundwater; Microseismic events; Subsidence; Environmental consideration at site; Gladys McCall No. 1 well; Test results of Gladys McCall; Hydrocarbons in production gas and brine; Environmental monitoring at the Gladys McCall site; Pleasant Bayou No. 2 well; Pleasant Bayou hybrid power system; Environmental monitoring at Pleasant Bayou; and Plug abandonment and well site restoration of three geopressured-geothermal test sites. 197 figs., 64 tabs.« less

Role of 18F-FDG PET/CT in diagnosing peritoneal carcinomatosis in the restaging of patient with ovarian cancer as compared to contrast enhanced CT and tumor marker Ca-125.

PubMed

Rubini, G; Altini, C; Notaristefano, A; Merenda, N; Rubini, D; Ianora, A A Stabile; Asabella, A Niccoli

2014-01-01

To investigate the role of whole-body fluorine-18-2-deoxy-2-fluoro-d-glucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) in the identification of peritoneal carcinomatosis in patients with ovarian cancer (OC). Seventy-nine patients with histologically proven stages III-IV OC who underwent (18)F-FDG PET/CT were studied retrospectively. We considered group A as 51 patients who also underwent computed-tomography with contrast-enhancement (CECT), and group B as 35 patients who had also been tested for biomarker Ca-125. Sensitivity, specificity, accuracy, positive predictive values (PPV) and negative predictive values (NPV) of (18)F-FDG PET/CT as compared to CECT and to Ca-125 were evaluated. (18)F-FDG PET/CT' sensitivity, specificity, accuracy, PPV and NPV for all 79 patients were: 85%, 92.31%, 88.61%, 91.89% and 85.71%, respectively. (18)F-FDG PET/CT sensitivity in group A was 78.6%, while it was 53.6% for CECT. (18)F-FDG PET/CT specificity, calculated in the same group, was 91.3%, while that of CECT was 60.9% (statistically significant difference, McNemar 4, P=0.039). Accuracy was 84.3% and 56.9%, respectively. (18)F-FDG PET/CT' sensitivity in group B was 86.4%, while that of Ca-125 was 81.8% (no statistical difference, McNemar 0, P=1). (18)F-FDG PET/CT specificity in group B was 84.6% while that of Ca-125 was 38.5% (clear but not statistically significant difference, McNemar 3.12, P=0.070). Accuracy calculated in the same group was 85.7% for (18)F-FDG PET/CT and 65.7% for Ca-125. (18)F-FDG PET/CT is a useful diagnostic tool when peritoneal biopsy cannot be performed and it can better select those who are candidates for adjuvant chemotherapy. Copyright © 2013 Elsevier España, S.L. and SEMNIM. All rights reserved.

"The feasibility of implementing cognitive remediation for work in community based psychiatric rehabilitation programs": Correction to McGurk et al. (2017).

PubMed

2017-06-01

Reports an error in "The feasibility of implementing cognitive remediation for work in community based psychiatric rehabilitation programs" by Susan R. McGurk, Kim T. Mueser, Melanie A. Watkins, Carline M. Dalton and Heather Deutsch ( Psychiatric Rehabilitation Journal , 2017[Mar], Vol 40[1], 79-86). In the article, the author order was incorrect due to a printer error. The online version of this article has been corrected. (The following abstract of the original article appeared in record 2017-13255-004.) Objective: Adding cognitive remediation to vocational rehabilitation services improves cognitive and work functioning in people with serious mental illness, but despite interest, the uptake of cognitive programs into community services has been slow. This study evaluated the feasibility of implementing an empirically supported cognitive remediation program in routine rehabilitation services at 2 sites. The Thinking Skills for Work (TSW) program was adapted for implementation at 2 sites of a large psychiatric rehabilitation agency providing prevocational services, but not community-based vocational services, which were provided off-site. Agency staff were trained to deliver TSW to clients with work or educational goals. Cognitive assessments were conducted at baseline and posttreatment, with work and school activity tracked for 2 years. Eighty-three participants enrolled in TSW, of whom 79.5% completed at least 6 of the 24 computer cognitive exercise sessions (M = 16.7) over an average of 18 weeks. Participants improved significantly from baseline to posttreatment in verbal learning and memory, speed of processing, and overall cognitive functioning. Over the follow-up, 25.3% of participants worked and 47.0% were involved in work or school activity. Higher work rates were observed at the site where participants had easier access to vocational services. The results support the feasibility of implementing the TSW program by frontline staff in agencies providing psychiatric rehabilitation, and suggest that ease of access to vocational services may influence work outcomes. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Application of superplastically formed and diffusion bonded aluminum to a laminar flow control leading edge

NASA Technical Reports Server (NTRS)

Goodyear, M. D.

1987-01-01

NASA sponsored the Aircraft Energy Efficiency (ACEE) program in 1976 to develop technologies to improve fuel efficiency. Laminar flow control was one such technology. Two approaches for achieving laminar flow were designed and manufactured under NASA sponsored programs: the perforated skin concept used at McDonnell Douglas and the slotted design used at Lockheed-Georgia. Both achieved laminar flow, with the slotted design to a lesser degree (JetStar flight test program). The latter design had several fabrication problems concerning springback and adhesive flow clogging the air flow passages. The Lockheed-Georgia Company accomplishments is documented in designing and fabricating a small section of a leading edge article addressing a simpler fabrication method to overcome the previous program's manufacturing problems, i.e., design and fabrication using advanced technologies such as diffusion bonding of aluminum, which has not been used on aerospace structures to date, and the superplastic forming of aluminum.

Life science experiments during parabolic flight: The McGill experience

NASA Technical Reports Server (NTRS)

Watt, D. G. D.

1988-01-01

Over the past twelve years, members of the Aerospace Medical Research Unit of McGill University have carried out a wide variety of tests and experiments in the weightless condition created by parabolic flight. This paper discusses the pros and cons of that environment for the life scientist, and uses examples from the McGill program of the types of activities which can be carried out in a transport aircraft such as the NASA KC-135.

PLANNING AND COORDINATION OF ACTIVITIES SUPPORTING THE RUSSIAN SYSTEM OF CONTROL AND ACCOUNTING OF NUCLEAR MATERIALS AT ROSATOM FACILITIES IN THE FRAMEWORK OF THE U.S.-RUSSIAN COOPERATION.

DOE Office of Scientific and Technical Information (OSTI.GOV)

SVIRIDOVA, V.V.; ERASTOV, V.V.; ISAEV, N.V.

2005-05-16

The MC&A Equipment and Methodological Support Strategic Plan (MEMS SP) for implementing modern MC&A equipment and methodologies at Rosatom facilities has been developed within the framework of the U.S.-Russian MPC&A Program. This plan developed by the Rosatom's Russian MC&A Equipment and Methodologies (MEM) Working Group and is coordinated by that group with support and coordination provided by the MC&A Measurements Project, Office of National Infrastructure and Sustainability, US DOE. Implementation of different tasks of the MEMS Strategic Plan is coordinated by Rosatom and US-DOE in cooperation with different U.S.-Russian MC&A-related working groups and joint site project teams. This cooperation allowsmore » to obtain and analyze information about problems, current needs and successes at Rosatom facilities and facilitates solution of the problems, satisfying the facilities' needs and effective exchange of expertise and lessons learned. The objective of the MEMS Strategic Plan is to enhance effectiveness of activities implementing modern equipment and methodologies in the Russian State MC&A system. These activities are conducted within the joint Russian-US MPC&A program aiming at reduction of possibility for theft or diversion of nuclear materials and enhancement of control of nuclear materials.« less

Sorting in-shell walnuts using near infrared spectroscopy for improved drying efficiency and product quality

USDA-ARS?s Scientific Manuscript database

In the current walnut drying practice, dryers comingle nuts with varying moisture contents (MC) which results in over drying of nuts with low MC and thereby decrease product quality. The objectives of this research were to investigate correlations among near infrared (NIR) spectral data and MC of fr...

2011 Agile (Scrum) Workshop Held in Baltimore, Maryland on November 14-15, 2011

DTIC Science & Technology

2011-11-15

have success- fully implemented Agile Development within DoD. SUSI MCKEE OC2IS Program Manager, U.S. Air Force Susana V. McKee has 25 years of DoD T...AGILE WILL WORK IN DOD: THREE EXAMPLES u Ms. Kelly Goshorn, Patriot Excalibur (PEX) Program Manager, U.S. Air Force u Ms. Susi McKee, Operational...OPS PEX Team: Internal •Devs/SMEs/Testers •Architecture Committee •Etc. none Future implementation, not Current release Big R/ Little r I n

McDonnell Douglas Helicopter Company independent research and development: Preparing for the future

NASA Technical Reports Server (NTRS)

Haggerty, Allen C.

1988-01-01

During the 1970's and 80's, research has produced the technology that is seen in aircraft such as the LHX and future models. The technology is discussed that is reaching maturity and moving into the application stage of future programs. Technology is discussed in six major areas: advanced concepts, analysis techniques, structures, systems, simulation, and research and development facilities. The partnership of McDonnell Douglas Helicopter Co. and the government in developing these technologies is illustrated in several programs.

Transcripts of Regional Hearings, St. Louis, Missouri. Annex L to Adjusting to the Drawdown. Report of the Defense Conversion Commission

DTIC Science & Technology

1992-08-01

entrepreneurship courses for laid-off McDonnell Douglas employees. Over 500 have participated in the classes. • McDonnell Douglas donated its lease-hold...international programs and organizations • Analysis of regional financing programs The St. Louis World Trade Center franchise was acquired for the region...averaged over the 1970’s, the defense cutbacks are likely contribute only a small part of that objective. 2 38 7 Figure 5.3 REAL GDP BASE VS

Correct Requirements, A Factor for Success in Major Acquisition Programs

DTIC Science & Technology

2008-06-01

23 See Organizational Behavior, Mc Shane/von Glinow, Mc Graw -Hill/Irwin, New York 2007, chapter 14. 24 As stated during MN3304 class...57 LIST OF REFERENCES Apte, Aruna. (2006). Spiral Development: A perspective.NPS-GSBPP-05-009. Banus, Stephen P. (1997). Financing contingency

Movement Correction Method for Human Brain PET Images: Application to Quantitative Analysis of Dynamic [18F]-FDDNP Scans

PubMed Central

Wardak, Mirwais; Wong, Koon-Pong; Shao, Weber; Dahlbom, Magnus; Kepe, Vladimir; Satyamurthy, Nagichettiar; Small, Gary W.; Barrio, Jorge R.; Huang, Sung-Cheng

2010-01-01

Head movement during a PET scan (especially, dynamic scan) can affect both the qualitative and quantitative aspects of an image, making it difficult to accurately interpret the results. The primary objective of this study was to develop a retrospective image-based movement correction (MC) method and evaluate its implementation on dynamic [18F]-FDDNP PET images of cognitively intact controls and patients with Alzheimer’s disease (AD). Methods Dynamic [18F]-FDDNP PET images, used for in vivo imaging of beta-amyloid plaques and neurofibrillary tangles, were obtained from 12 AD and 9 age-matched controls. For each study, a transmission scan was first acquired for attenuation correction. An accurate retrospective MC method that corrected for transmission-emission misalignment as well as emission-emission misalignment was applied to all studies. No restriction was assumed for zero movement between the transmission scan and first emission scan. Logan analysis with cerebellum as the reference region was used to estimate various regional distribution volume ratio (DVR) values in the brain before and after MC. Discriminant analysis was used to build a predictive model for group membership, using data with and without MC. Results MC improved the image quality and quantitative values in [18F]-FDDNP PET images. In this subject population, medial temporal (MTL) did not show a significant difference between controls and AD before MC. However, after MC, significant differences in DVR values were seen in frontal, parietal, posterior cingulate (PCG), MTL, lateral temporal (LTL), and global between the two groups (P < 0.05). In controls and AD, the variability of regional DVR values (as measured by the coefficient of variation) decreased on average by >18% after MC. Mean DVR separation between controls and ADs was higher in frontal, MTL, LTL and global after MC. Group classification by discriminant analysis based on [18F]-FDDNP DVR values was markedly improved after MC. Conclusion The streamlined and easy to use MC method presented in this work significantly improves the image quality and the measured tracer kinetics of [18F]-FDDNP PET images. The proposed MC method has the potential to be applied to PET studies on patients having other disorders (e.g., Down syndrome and Parkinson’s disease) and to brain PET scans with other molecular imaging probes. PMID:20080894

Auditing and inspection-area liason program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wilson, W.A.

1989-01-01

Prior to 1986 the Material Control and Accountability (MC and A) organization at the Savannah River Site (SRS) was centrally located in the administration area. Since most production facilities are located at least 7-15 miles from the administration area, there was very little interaction between MC and A and operations personnel. Oversight of site material control and accountability practices was limited to periodic audits conducted by an accountant assigned to the MC and A organization. These audits focused mainly on accountability practices. With increased emphasis placed on material control in recent years, it became imperative that the MC and Amore » organization have representation in the production areas at SRS. Therefore, the position of MC and A area liaison was formed. The concept was to place technical personnel in the key production areas at SRS to assume MC and A auditing responsibilities in those areas, and more importantly, interact with area personnel to provide MC and A oversight and guidance on a day-to-day basis« less

Improved Assessment Strategies for Vapor Intrusion Passive Samplers and Building Pressure Control

DTIC Science & Technology

2013-09-01

pressure control. Matrix Analyte Method Container Holding Time (Days) Vapor Radon McHugh , Hammond, Nickels , and Hartman, 2008 Tedlar ® bag 14...2: Diffusive Sampling,” ISO 16017-2:2003. McHugh T. E., D. E. Hammond, T. Nickels , and B. Hartman. 2008. “Use of Radon Measurements for Evaluation...Control I. D. Rivera-Duarte D. B. Chadwick SSC Pacific T. McAlary H. Groenevelt T. Creamer D. Bertrand Geosyntec Consultants, Inc. T. McHugh

Minimum Energy Routing through Interactive Techniques (MERIT) modeling

NASA Technical Reports Server (NTRS)

Wylie, Donald P.

1988-01-01

The MERIT program is designed to demonstrate the feasibility of fuel savings by airlines through improved route selection using wind observations from their own fleet. After a discussion of weather and aircraft data, manually correcting wind fields, automatic corrections to wind fields, and short-range prediction models, it is concluded that improvements in wind information are possible if a system is developed for analyzing wind observations and correcting the forecasts made by the major models. One data handling system, McIDAS, can easily collect and display wind observations and model forecasts. Changing the wind forecasts beyond the time of the most recent observations is more difficult; an Australian Mesoscale Model was tested with promising but not definitive results.

Motivational interviewing combined with chess accelerates improvement in executive functions in cocaine dependent patients: a one-month prospective study.

PubMed

Gonçalves, Priscila Dib; Ometto, Mariella; Bechara, Antoine; Malbergier, André; Amaral, Ricardo; Nicastri, Sergio; Martins, Paula A; Beraldo, Livia; dos Santos, Bernardo; Fuentes, Daniel; Andrade, Arthur G; Busatto, Geraldo F; Cunha, Paulo Jannuzzi

2014-08-01

In cocaine-dependent individuals, executive function (EF) deficits are associated with poor treatment outcomes. Psychological interventions and pharmacological approaches have produced only modest effect sizes. To date, studies of this topic have been few and limited. The aim of this study was to examine the effects of a new model of intervention, which integrates chess and Motivational Interviewing, Motivational Chess (MC) METHODS: We evaluated 46 cocaine-dependent inpatients (aged 18-45), in two groups-MC (n=26); and active comparison-AC (n=20). Using neuropsychological tests and an impulsivity scale, we assessed the subjects before and after the study period (one month of abstinence monitored by urine toxicology screening). The MC and AC groups did not differ at baseline. In the post-intervention assessment (after one month), both groups showed significant improvements in attention, mental flexibility, inhibitory control, abstraction abilities, and decision-making (p<0.01). In addition, the improvement in working memory was more significant in the MC group than in the AC group (group-by-time interaction, p=01). One month of abstinence was sufficient to improve various attentional and executive domains in cocaine-dependent subjects. The MC intervention was associated with greater improvements in EFs, especially working memory, suggesting that tailored interventions focusing on complex EFs accelerate the process of cognitive recovery during the initial period of abstinence. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

NASA Graduate Student Researchers Program Ronald E. McNair PhD Program

NASA Technical Reports Server (NTRS)

Howard, Sunnie

1998-01-01

The NASA Ronald E. McNair PHD Program was funded in September 1995. Implementation began during the spring of 1996. The deferment of the actual program initial semester enabled the program to continue support through the fall semester of 1998. This was accomplished by a no-cost extension from August 15, 1998 through December 31, 1998. There were 12 fellows supported by the program in 1996, 15 fellows in 1997, and 15 fellows 1998. Current program capacity is 15 fellows per funding support. Support for the academic outreach component began in spring 1998. The program was named the "Good Enough" Crew Activity (GECA) in honor of Dr. McNair's philosophy of everyone being good enough to achieve anything they want bad enough. The program currently enrolls 65 students from the third through the eight grades. The program is held 12 Saturdays per semester. The time is 9:00 AM to 12:30 PM each Saturday Morning. Program direction and facilitation is jointly administered with the PHD fellows and the Saturday Academy staff. Dr. John Kelly, REM-PHD Principal Investigator serves in a program oversight and leadership capacity. Ms. Sunnie Howard, The NASA REM-PHD Administrative Coordinator serves in an administrative and logistical capacity. Mr. Aaron Hatch, the NASA-AMES Liaison Officer, serve@'in a consultative and curriculum review capacity. The first recognition activity will be held on December 12, 1998, with the students, parents, faculty, PHD fellows, and other local student support services persons. Program outreach efforts are jointly supported by the NASA REM-PHD Program and the National Space Grant College and Fellowship Program. The Ph.D. program reached its first milestone in May 1998. North Carolina A&T State University graduated the first Ph.D. fellows. The first three Ph.D. Alumni were Ronald E. McNair PHD Program Fellows. It is hoped that this is just the beginning of a highly acclaimed doctoral program. The ultimate program success will be recognized when the program begins to graduate 15 fellows per year. The Ph.D. Program is only three and a half years old and the expectations of graduating PH.D's in that timeframe, is a phenomenal accomplishment for any program in the country. Since inception of the NASA REM-PHD program, tuitions and fees have increased. Stipend support was increased to offer the Ph.D. program on a competitive basis. These increases will place allocation restraints on r_ the current level of funding. These issues are being addressed in the proposal and will bear their own merit.

Enhanced mesenchymal cell engraftment by IGF-1 improves left ventricular function in rats undergoing myocardial infarction.

PubMed

Enoki, Chiharu; Otani, Hajime; Sato, Daisuke; Okada, Takayuki; Hattori, Reiji; Imamura, Hiroji

2010-01-07

We hypothesized that enhanced mesenchymal cell (MC) engraftment with insulin-like growth factor-1 (IGF-1) improves left ventricular (LV) function and survival. IGF-1 (10 microg/ml) increased adhesion and inhibited apoptosis under hypoxia in vitro through activation of phosphatidylinositol 3-kinase (PI3K) in bone marrow-derived MCs obtained from transgenic rats expressing green fluorescence protein. Myocardial infarction (MI) in rats was produced by ligature of the left coronary artery. One month after MI, rat hearts were injected with MCs in the presence or absence of 10 microg/ml IGF-1 with or without PI3K inhibitor, 5 microM LY294002. IGF-1 significantly increased engraftment of MCs between 6 h and 3 days after transplantation associated with the increase in stromal cell-derived factor-1alpha in the infracted LV. The transplanted MCs had disappeared 1 month after transplantation in all groups. MC transplantation with IGF-1 significantly increased neovascularization and inhibited cardiomyocyte apoptosis 3 days and 1 month after MC transplantation. This was associated with improved LV function 1 month after MC transplantation and eventually survival. LY294002 abrogated all of the beneficial effects of MC transplantation with IGF-1. IGF-1 alone had no effect on neovascularization and did not improve LV function and/or survival. These results suggest that IGF-1 improves engraftment of MCs at the time of transplantation via activation of PI3K and this improved engraftment of MCs may be attributed to an increased neovascularization and inhibition of cardiomyocyte death, leading to improvement of LV function and prolongation of survival despite the eventual loss of the transplanted MCs.

Berkeley Lab Sheds Light on Improving Solar Cell Efficiency

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lawrence Berkeley National Laboratory

2007-07-20

Typical manufacturing methods produce solar cells with an efficiency of 12-15%; and 14% efficiency is the bare minimum for achieving a profit. In work performed at the Ernest Orlando Lawrence Berkeley National Laboratory (Berkeley, CA, 5 10-486-577 1)--a US Department of Energy national laboratory that conducts unclassified scientific research and is managed by the University of California--scientist Scott McHugo has obtained keen insights into the impaired performance of solar cells manufactured from polycrystalline silicon. The solar cell market is potentially vast, according to Berkeley Lab. Lightweight solar panels are highly beneficial for providing electrical power to remote locations in developingmore » nations, since there is no need to build transmission lines or truck-in generator fuel. Moreover, industrial nations confronted with diminishing resources have active programs aimed at producing improved, less expensive solar cells. 'In a solar cell, there is a junction between p-type silicon and an n-type layer, such as diffused-in phosphorous', explained McHugo, who is now with Berkeley Lab's Accelerator and Fusion Research Division. 'When sunlight is absorbed, it frees electrons, which start migrating in a random-walk fashion toward that junction. If the electrons make it to the junction; they contribute to the cell's output of electric current. Often, however, before they reach the junction, they recombine at specific sites in the crystal' (and, therefore, cannot contribute to current output). McHugo scrutinized a map of a silicon wafer in which sites of high recombination appeared as dark regions. Previously, researchers had shown that such phenomena occurred not primarily at grain boundaries in the polycrystalline material, as might be expected, but more often at dislocations in the crystal. However, the dislocations themselves were not the problem. Using a unique heat treatment technique, McHugo performed electrical measurements to investigate the material at the dislocations. He was purportedly the first to show that they were 'decorated' with iron.« less

Accelerated SPECT Monte Carlo Simulation Using Multiple Projection Sampling and Convolution-Based Forced Detection

NASA Astrophysics Data System (ADS)

Liu, Shaoying; King, Michael A.; Brill, Aaron B.; Stabin, Michael G.; Farncombe, Troy H.

2008-02-01

Monte Carlo (MC) is a well-utilized tool for simulating photon transport in single photon emission computed tomography (SPECT) due to its ability to accurately model physical processes of photon transport. As a consequence of this accuracy, it suffers from a relatively low detection efficiency and long computation time. One technique used to improve the speed of MC modeling is the effective and well-established variance reduction technique (VRT) known as forced detection (FD). With this method, photons are followed as they traverse the object under study but are then forced to travel in the direction of the detector surface, whereby they are detected at a single detector location. Another method, called convolution-based forced detection (CFD), is based on the fundamental idea of FD with the exception that detected photons are detected at multiple detector locations and determined with a distance-dependent blurring kernel. In order to further increase the speed of MC, a method named multiple projection convolution-based forced detection (MP-CFD) is presented. Rather than forcing photons to hit a single detector, the MP-CFD method follows the photon transport through the object but then, at each scatter site, forces the photon to interact with a number of detectors at a variety of angles surrounding the object. This way, it is possible to simulate all the projection images of a SPECT simulation in parallel, rather than as independent projections. The result of this is vastly improved simulation time as much of the computation load of simulating photon transport through the object is done only once for all projection angles. The results of the proposed MP-CFD method agrees well with the experimental data in measurements of point spread function (PSF), producing a correlation coefficient (r2) of 0.99 compared to experimental data. The speed of MP-CFD is shown to be about 60 times faster than a regular forced detection MC program with similar results.

Photometric Detection of Extra-Solar Planets

NASA Technical Reports Server (NTRS)

Hatzes, Artie P.; Cochran, William D.

2004-01-01

This NASA Origins Program grant supported the TEMPEST Texas McDonald Photometric Extrasolar Search for Transits) program at McDonald Observatory, which searches for transits of extrasolar planets across the disks of their parent stars. The basic approach is to use a wide-field ground-based telescope (in our case the McDonald Observatory 0.76m telescope and it s Prime Focus Corrector) to search for transits of short period (1-15 day orbits) of close-in hot-Jupiter planets in orbit around a large sample of field stars. The next task is to search these data streams for possible transit events. We collected our first set of test data for this program using the 0.76 m PFC in the summer of 1998. From those data, we developed the optimal observing procedures, including tailoring the stellar density, exposure times, and filters to best-suit the instrument and project. In the summer of 1999, we obtained the first partial season of data on a dedicated field in the constellation Cygnus. These data were used to develop and refine the reduction and analysis procedures to produce high-precision photometry and search for transits in the resulting light curves. The TeMPEST project subsequently obtained three full seasons of data on six different fields using the McDonald Observatory 0.76m PFC.

Effect of Baseline Spastic Hemiparesis on Recovery of Upper-Limb Function Following Botulinum Toxin Type A Injections and Postinjection Therapy

PubMed Central

Chang, Chia-Lin; Munin, Michael C.; Skidmore, Elizabeth R.; Niyonkuru, Christian; Huber, Lynne M.; Weber, Douglas J.

2015-01-01

Objective To determine whether baseline hand spastic hemiparesis assessed by the Chedoke-McMaster Assessment influences functional improvement after botulinum toxin type A (BTX-A) injections and postinjection therapy. Design Prospective cohort study. Setting Outpatient spasticity clinic. Participants Participants (N = 14) with spastic hemiparesis divided into 2 groups: Chedoke-McMaster Assessment Hand-Higher Function (stage≥4, n = 5) and Chedoke-McMaster Assessment Hand-Lower Function (stage = 2 or 3, n = 9). Interventions Upper-limb BTX-A injections followed by 6 weeks of postinjection therapy. Main Outcome Measures Primary outcomes were Motor Activity Log-28 and Motor Activity Log items. Secondary outcomes were Action Research Arm Test (ARAT), Motor Activity Log-Self-Report, and Modified Ashworth Scale (MAS). Measures were assessed at baseline (preinjection), 6 weeks, 9 weeks, and 12 weeks postinjection. Results Primary and secondary outcomes improved significantly over time in both groups. Although no significant differences in ARAT or MAS change scores were noted between groups, Chedoke-McMaster Assessment Hand-Higher Function group demonstrated greater change on Motor Activity Log-28 (P = .013) from baseline to 6 weeks and Motor Activity Log items (P = .006) from baseline to 12 weeks compared to Chedoke-McMaster Assessment Hand-Lower Function group. Conclusions BTX-A injections and postinjection therapy improved hand function and reduced spasticity for both Chedoke-McMaster Assessment Hand-Higher Function and Chedoke-McMaster Assessment Hand-Lower Function groups. Clinicians should expect to see larger gains for persons with less baseline impairment. PMID:19735772

A Matter of Principals

ERIC Educational Resources Information Center

Fletcher, Geoffrey H.

2009-01-01

Scott McLeod says the great sin in the way professional development is provided in this country is one of omission. On his blog, McLeod, an associate professor in the Department of Educational Leadership and Policy Studies at Iowa State University and the coordinator of the department's Educational Administration Program, writes, "Most of our…

2000 African American History Month Celebration Luncheon

NASA Technical Reports Server (NTRS)

2000-01-01

Mack McKinney (left), chief, Programs Resources Management, and Delores Abraham (right), with the Astronaut office, flank one of the posters decorating the Early Space Exploration Conference Center at the KSC Visitor Complex for the 2000 African American History Month Celebration Luncheon. McKinney is chairperson for the event.

76 FR 21753 - Noncompetitive Program Extension Supplemental Awards

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-18

... Medicine H30 MC00019-20-00 Region 2 595,453 Children's Hospital of Philadelphia... H30 MC09625-02-00 Region... issuing non-competitive supplemental funding to the Maternal Child and Health Bureau's (MCHB) Comprehensive Hemophilia Diagnostic and Treatment Centers. MCHB's Division of Children with Special Health Needs...

Prioritizing Medical Resources for Exploration Missions

NASA Technical Reports Server (NTRS)

Shah, R. V.; Kerstman, E. L.

2015-01-01

Long duration missions beyond low Earth orbit introduce new constraints to the medical system. Factors such as the inability to evacuate to Earth in a timely manner, communication delay, limitations in available medical equipment, and the clinical background of the crew will all have an impact on the assessment and treatment of medical conditions. The Exploration Medical Capability (ExMC) Element of NASAs Human Research Program seeks to improve the way the element derives its mitigation strategies for the risk of "Unacceptable Health and Mission Outcomes Due to Limitation of In-flight Medical Capabilities."

Verification of an improved computational design procedure for TWT-dynamic refocuser-MDC systems with secondary electron emission losses

NASA Technical Reports Server (NTRS)

Ramins, P.; Force, D. A.; Palmer, R. W.; Dayton, J. A., Jr.; Kosmahl, H. G.

1986-01-01

A computational procedure for the design of TWT-refocuser-MDC systems was used to design a short 'dynamic' refocusing system and highly efficient four-stage depressed collector for a 200-W 8-18-GHz TWT. The computations were carried out with advanced multidimensional computer programs which model the electron beam as a series of disks of charge and follow their trajectories from the RF input of the TWT, through the slow-wave structure and refocusing section, to their points of impact in the depressed collector. Secondary emission losses in the MDC were treated semiquantitatively by injecting a representative beam of secondary electrons into the MDC analysis at the point of impact of each primary beam. A comparison of computed and measured TWT and MDC performance showed very good agreement. The electrodes of the MDC were fabricated from a particular form of isotropic graphite that was selected for its low secondary electron yield, thermal expansion characteristics, ease of machinability and vacuum properties. This MDC was tested at CW for more than 1000 h with negligible degradation in TWT and MDC performances.

Revising Army National Guard Officer Retention Boards

DTIC Science & Technology

2006-02-06

performance in the corporate world by a multi-national U. S . based corporation is McDonalds . This well known company, founded in 1955, was the... franchising ) to grow McDonalds into the premier fast food giant it has become. McDonald’s recently set a mandatory retirement age for its executives...Retention Boards 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR( S ) Keith Mabry 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK

Tools for the Conceptual Design and Engineering Analysis of Micro Air Vehicles

DTIC Science & Technology

2009-03-01

problem with two DC motors with propellers, mounted on each wing tip and oriented such that the thrust vectors had an angular separation of 180...ElectriCalc or MotoCalc Database • Script Program (MC) In determination of the components to be integrated into MC, the R/C world was explored since the tools...Excel, ProE, QuickWrap and Script . Importing outside applications can be achieved by direct interaction with MC or through analysis server connections [11

Installation Restoration Program (IRP) Stage 3. McClellan Air Force Base. Operable Unit B. Preliminary Assessment Summary Report. Volume 2. Appendix B (Part 2)

DTIC Science & Technology

1991-10-01

the Industrial Wastewater Collection System (IWCS) for leaks and analyzed wastewater passing through the wastewater lines (the IWL) at McClellan AFB (EG...Wastewater Collection System (IWCS) is a system of underground pipes and lift stations used to collect the wastewater from the various base processes...and work areas for treatment at one centralized Industrial Wastewater Treatment Plant (IWTP) located in OU C McClellan AFB. Most of the system is

PAMAM dendrimer-baculovirus nanocomplex for microencapsulated adipose stem cell-gene therapy: in vitro and in vivo functional assessment.

PubMed

Paul, Arghya; Shao, Wei; Abbasi, Sana; Shum-Tim, Dominique; Prakash, Satya

2012-09-04

The present study aims to develop a new stem cell based gene delivery system consisting of human adipose tissue derived stem cells (hASCs) genetically modified with self-assembled nanocomplex of recombinant baculovirus and PAMAM dendrimer (Bac-PAMAM) to overexpress the vascular endothelial growth factor (VEGF). Cells were enveloped into branched PEG surface functionalized polymeric microcapsules for efficient transplantation. In vitro analysis confirmed efficient transduction of hASCs expressing 7.65 ± 0.86 ng functionally active VEGF per 10(6) microencapsulated hASCs (ASC-VEGF). To determine the potential of the developed system, chronically infarcted rat hearts were treated with either empty microcapsules (MC), microencapsulated hASCs expressing MGFP reporter protein (MC+ASC-MGFP), or MC+ASC-VEGF, and analyzed for 10 weeks. Post-transplantation data confirmed higher myocardial VEGF expressions with significantly enhanced neovasculature in the MC+ASC-VEGF group. In addition, the cardiac performance, as measured by percentage ejection fraction, also improved significantly in the MC+ASC-VEGF group (48.6 ± 6.1%) compared to that in MC+ASC-MGFP (38.8 ± 5.3%) and MC groups (31.5 ± 3.3%). Collectively, these data demonstrate the feasibility of this system for improved stem cell therapy applications.

In-simulator training of driving abilities in a person with a traumatic brain injury.

PubMed

Gamache, Pierre-Luc; Lavallière, Martin; Tremblay, Mathieu; Simoneau, Martin; Teasdale, Normand

2011-01-01

This study reports the case of a 23-year-old woman (MC) who sustained a severe traumatic brain injury in 2004. After her accident, her driving license was revoked. Despite recovering normal neuropsychological functions in the following years, MC was unable to renew her license, failing four on-road evaluations assessing her fitness to drive. In hope of an eventual license renewal, MC went through an in-simulator training programme in the laboratory in 2009. The training programme aimed at improving features of MC's driving behaviour that were identified as being problematic in prior on-road evaluations. To do so, proper driving behaviour was reinforced via driving-specific feedback provided during the training sessions. After 25 sessions in the simulator (over a period of 4 months), MC significantly improved various components of her driving. Notably, compared to early sessions, later ones were associated with a reduced cognitive load, less jerky speed profiles when stopping at intersections and better vehicle control and positioning. A 1-year retention test showed most of these improvements were consistent. The learning principles underlying well conducted simulator-based education programmes have a strong scientific basis. A simulator training programme like this one represents a promising avenue for driving rehabilitation. It allows individuals without a driving license to practice and improve their skills in a safe and realistic environment.

Grain Refinement and Improvement of Solidification Defects in Direct-Chill Cast Billets of A4032 Alloy by Melt Conditioning

NASA Astrophysics Data System (ADS)

Li, Hu-Tian; Zhao, Pizhi; Yang, Rongdong; Patel, Jayesh B.; Chen, Xiangfu; Fan, Zhongyun

2017-10-01

Melt-conditioned, direct-chill (MC-DC) casting is an emerging technology to manipulate the solidification process by melt conditioning via intensive shearing in the sump during DC casting to tailor the solidification microstructure and defect formation. When using MC-DC casting technology in an industrial scale DC cast billet of an A4032 aluminum alloy, significant grain refinement and uniform microstructure can be achieved in the primary α-Al phase with fine secondary dendritic arm spacing (SDAS). Improved macrosegregation is quantitatively characterized and correlated with the suppression of channel segregation. The mechanisms for the prevention of channel segregation are attributed to the increased local cooling rate in the liquid-solid phase region in the sump and the formation of fine equiaxed dendritic grains under intensive melt shearing during MC-DC casting. A critical cooling rate has been identified to be around 0.5 to 1 K/s (°C/s) for the channel segregation to happen in the investigated alloy based on quantitative metallographic results of SDAS. Reduction and refinement of microporosity is attributed to the improved permeability in the liquid-solid phase region estimated by the Kozeny-Carman relationship. The potential improvement in the mechanical properties achievable in MC-DC cast billets is indicated by the finer and more uniform forging streamline in the forgings of MC-DC cast billet.

Efficiency in nonequilibrium molecular dynamics Monte Carlo simulations

DOE PAGES

Radak, Brian K.; Roux, Benoît

2016-10-07

Hybrid algorithms combining nonequilibrium molecular dynamics and Monte Carlo (neMD/MC) offer a powerful avenue for improving the sampling efficiency of computer simulations of complex systems. These neMD/MC algorithms are also increasingly finding use in applications where conventional approaches are impractical, such as constant-pH simulations with explicit solvent. However, selecting an optimal nonequilibrium protocol for maximum efficiency often represents a non-trivial challenge. This work evaluates the efficiency of a broad class of neMD/MC algorithms and protocols within the theoretical framework of linear response theory. The approximations are validated against constant pH-MD simulations and shown to provide accurate predictions of neMD/MC performance.more » An assessment of a large set of protocols confirms (both theoretically and empirically) that a linear work protocol gives the best neMD/MC performance. Lastly, a well-defined criterion for optimizing the time parameters of the protocol is proposed and demonstrated with an adaptive algorithm that improves the performance on-the-fly with minimal cost.« less

Modeling of transitional flows

NASA Technical Reports Server (NTRS)

Lund, Thomas S.

1988-01-01

An effort directed at developing improved transitional models was initiated. The focus of this work was concentrated on the critical assessment of a popular existing transitional model developed by McDonald and Fish in 1972. The objective of this effort was to identify the shortcomings of the McDonald-Fish model and to use the insights gained to suggest modifications or alterations of the basic model. In order to evaluate the transitional model, a compressible boundary layer code was required. Accordingly, a two-dimensional compressible boundary layer code was developed. The program was based on a three-point fully implicit finite difference algorithm where the equations were solved in an uncoupled manner with second order extrapolation used to evaluate the non-linear coefficients. Iteration was offered as an option if the extrapolation error could not be tolerated. The differencing scheme was arranged to be second order in both spatial directions on an arbitrarily stretched mesh. A variety of boundary condition options were implemented including specification of an external pressure gradient, specification of a wall temperature distribution, and specification of an external temperature distribution. Overall the results of the initial phase of this work indicate that the McDonald-Fish model does a poor job at predicting the details of the turbulent flow structure during the transition region.

Is it time for a new classification of mast cells? What do we know about mast cell heterogeneity?

PubMed

Frossi, Barbara; Mion, Francesca; Sibilano, Riccardo; Danelli, Luca; Pucillo, Carlo E M

2018-03-01

Mast cells (MCs) are derived from committed precursors that leave the hematopoietic tissue, migrate in the blood, and colonize peripheral tissues where they terminally differentiate under microenvironment stimuli. They are distributed in almost all vascularized tissues where they act both as immune effectors and housekeeping cells, contributing to tissue homeostasis. Historically, MCs were classified into 2 subtypes, according to tryptic enzymes expression. However, MCs display a striking heterogeneity that reflects a complex interplay between different microenvironmental signals delivered by various tissues, and a differentiation program that decides their identity. Moreover, tissue-specific MCs show a trained memory, which contributes to shape their function in a specific microenvironment. In this review, we summarize the current state of our understanding of MC heterogeneity that reflects their different tissue experiences. We describe the discovery of unique cell molecules that can be used to distinguish specific MC subsets in vivo, and discuss how the improved ability to recognize these subsets provided new insights into the biology of MCs. These recent advances will be helpful for the understanding of the specific role of individual MC subsets in the control of tissue homeostasis, and in the regulation of pathological conditions such as infection, autoimmunity, and cancer. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

The Complete Heavy-Atom Structure of a Cp-Ftmw Chiral Tag Precursor, Verbenone

NASA Astrophysics Data System (ADS)

Marshall, Frank E.; West, Channing; Sedo, Galen; Pate, Brooks; Grubbs, G. S., II

2017-06-01

The microwave spectrum of the chiral molecule verbenone has been recorded from 2-18 GHz using two CP-FTMW spectrometers. 2-8 GHz data has been acquired on a 2-8 GHz CP-FTMW located at the University of Virginia and 8-18 data has been acquired on a 6-18 GHz spectrometer located at Missouri S&T. From the experiments the authors were able to assign and fit isotopologues corresponding to each heavy atom position (either ^{13}C or ^{18}O), providing for the heavy-atom structure. Previous studies by Evans and coworkers have been added to these measurements in a global fit of the parent species. The measurement and assignment of these transitions provide preliminary information needed for enatiomeric excess experiments using CP-FTMW van der Waals-type chiral tagging processes already being performed at UVa. Details of the experiment, fits, and structure will be discussed. C. J. Evans, S. M. Allpress, P. D. Godfrey, D. McNaughton, 67th International Symposium on Molecular Spectroscopy, 2012, RH13 S. M. Allpress, Spectroscopic and Computational Chemistry Studies on Terpene Related Compounds, University of Leicester, 2015, Chapter 6: Microwave Spectroscopy of Verbenone

[Papillary cystadenoma of the epididymis: a report of 2 cases and review of the literature].

PubMed

Zhang, Wei; Tu, Pin; Wang, Jian-jun; He, Yan; Yu, Bo; Wang, Hai; Shi, Qun-li

2015-02-01

To study the clinicopathological characteristics of papillary cystadenoma of the epididymis. Using routine pathology and immunohistochemistry, we observed the surgically obtained samples from 2 cases of papillary cystadenoma of the epididymis, analyzed their pathological features and clinical presentations, and reviewed the related literature. The 2 patients were both adult males. The tumors typically manifested as painless swelling in the epididymis, with occasionally dull pain and tenesmus in 1 of the cases. Pathologically, the lesions exhibited three morphological features, i. e., dilated ducts and small cysts surrounded by fibrous connective tissue, adenoid papillary hyperplasia into the cysts embraced by fibrovascular stroma, and acidophil substance present in the cysts. Immunohistochemistry showed that the tumors were strongly positive for CK8/18, CK7, and EMA, but negative for CK20, CEA, MC, Calretenin, P53, P63, SMA, VHL, and CD10, with the positive rate of Ki-67 <1%. Follow-up visits revealed good prognosis in both cases. Papillary cystadenoma of the epididymis is a rare benign tumor in the male urogenital system, which may be accompanied by the VHL syndrome. Surgery is the first choice for its treatment.

McGraw-Hill Programmed Reading Evaluation.

ERIC Educational Resources Information Center

Norfolk Public Schools, VA.

One of the programs included in "Effective Reading Programs...," this program, begun in 1972, serves about 3,600 disadvantaged first through fourth grade students. The independent learning approach is featured in this program. Placement tests help teachers determine each child's needs, and diagnostic tests monitor student progress.…

The effect of medical clowns on performance of spirometry among preschool aged children.

PubMed

Nir, Vered; Schichter-Konfino, Vered; Kassem, Eias; Klein, Adi

2018-04-02

Medical clowns (MCs) are known to assist in reducing pain and alleviating anxiety. The objective of this study is to evaluate the ability of MCs to assist preschoolers in performing spirometry. A prospective, randomized controlled trial. Children aged 3-6 years participated. After a first spirometry, children were divided into two groups: the first performed a second spirometry with an MC. The second repeated spirometry with the technician. Primary outcome was second spirometry values compared between the groups. Secondary outcome were change in spirometry values within groups, and difference between the groups. A total of 140 children participated. The groups did not differ in age, sex, mother tongue, or weight. Nor in mean FVC (MC 89.2% ± 16.7, control 89.5% ± 16.3) mean FEV1 (MC 91.3% ± 15.6, control 94.2% ± 16.8), and expiratory time (MC 1.58 ± 0.43, control 1.7 ± 0.44) in first spirometry. In second spirometry the control group had a similar FVC, FEV1, and expiratory time. The MC group had a significant improvement in all parameters: FVC: MC 95.3% ± 15.5, control 89.3% ± 19.1, FEV1: MC 98.0% ± 15.6, control 91.8% ± 19.3, and expiratory time MC 1.96 ± 0.55, control 1.84 ± 0.52. The differences between the groups between first and second attempt were significant (P-value FVC 0.000, FEV1 0.000, expiratory time 0.003). MCs improved performance of spirometry among preschoolers. It is possible that laughter and relief of stress had a physiological effect. Further studies are required to better establish the ability of MCs to improve active participation and to better understand whether the mechanism of the improvement is better cooperation or true physiological change. © 2018 Wiley Periodicals, Inc.

Bimanual Behaviours in Children Aged 8-18 Months: A Literature Review to Select Toys that Elicit the Use of Two Hands

ERIC Educational Resources Information Center

Greaves, Susan; Imms, Christine; Krumlinde-Sundholm, Lena; Dodd, Karen; Eliasson, Ann-Christin

2012-01-01

Toys that provoke the use of both hands are required to develop a test of bimanual performance in children 8-18 months with unilateral cerebral palsy (Mini-AHA). To choose the toys, a conceptual model based on perception-action theory and object use was used to guide a literature review. Evidence was sought for three critical relationships…

Indissoluble Connection of Russian MC&A System Sustainability with that of the Russian Methodological & Training Center

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ryazanov, Boris G.; Goryunov, Victor; Pshakin, Gennady M.

During the past 10 years of collaboration under the U.S.-Russian Materials Protection, Control and Accounting (MPC&A) Program great efforts were made to transform and upgrade the Russian Federal Nuclear Materials Control and Accounting (MC&A) System. The efforts were focused not only on MC&A systems for nuclear facilities but also on creating and developing the system infrastructure, including legislation, state inspection and agency monitoring, training of operators and inspectors, instrument and methodological support, and the Federal Information System (FIS). At present the most important and urgent goal is to provide sustainability of MC&A systems at the existing level or at themore » level that will be achieved in 2007-2008. Since the very beginning of the program, the Russian Methodological and Training Center (RMTC) activities have been focused on intensive training of the personnel as well as the methodological support necessary for transformation and development of the entire system and its elements located at nuclear facilities. Sustainability of the federal MC&A system is impossible without advanced training of personnel and methodological support for upgrading of system elements at nuclear facilities. That is why the RMTC sustainability is one of the key conditions required for the system sustainability as a whole. The paper presents the results of analysis of the conditions for the Russian MC&A system sustainable development in conjunction with the RMTC sustainability.« less

3D Bioprinting of Highly Thixotropic Alginate/Methylcellulose Hydrogel with Strong Interface Bonding.

PubMed

Li, Huijun; Tan, Yu Jun; Leong, Kah Fai; Li, Lin

2017-06-14

A robust alginate/methylcellulose (Alg/MC) blend hydrogel, with a strategy to improve adhesion between printed layers, has been fabricated for the first time for three-dimensional (3D) bioprinting. The optimized Alg/MC blend hydrogel exhibits a highly thixotropic property, great extrudability, and stackability. With treatment by a trisodium citrate (TSC) solution, the interfacial bonding between the printed layers is significantly improved. The TSC solution acts as a chelating agent to remove the superficial calcium ions at each layer. Post-cross-linking in a CaCl 2 bath after 3D printing further enhances the adhesion strength between the layers. The key parameters affecting the interfacial strength of the Alg/MC hydrogel are found to be the concentration of TSC, the volume of TSC, and the concentration of CaCl 2 in the bath. The Alg/MC hydrogel with the aid of TSC demonstrates superior printability, high stackability (150 layers can be printed), and high shape fidelity. A good cell viability of >95% is obtained for a freshly 3D-bioprinted Alg/MC construct. The novel Alg/MC hydrogel with the aid of TSC has been shown to have a great potential as an advanced 3D bioprinting material.

Transforming Individuals, Families, and Communities through Travel

ERIC Educational Resources Information Center

Austin, Tanya

2006-01-01

It was predicted that the 21st century would be an era of family stress and transformation (McCubbin, McCubbin, Thompson, Han, & Allen, 1997). When evaluating what families face today and what FCS professionals are addressing in current research, curriculum, and programming, it seems that this is indeed the case. Today's FCS professionals need to…

The Effect of Instrument-Specific Rater Training on Interrater Reliability and Counseling Skills Performance Differentiation

ERIC Educational Resources Information Center

Meacham, Paul Douglas, Jr.

2013-01-01

The purpose of this study was to explore the effect of instrument-specific rater training on interrater reliability (IRR) and counseling skills performance differentiation. Strong IRR is of primary concern to effective program evaluation (McCullough, Kuhn, Andrews, Valen, Hatch, & Osimo, 2003; Schanche, Nielsen, McCullough, Valen, &…

The Work of Scholars: An Institutional Ethnography of a McNair Scholars' Class

ERIC Educational Resources Information Center

Vaughan, Terry, III

2017-01-01

The McNair Scholars Program continues to be pivotal towards increasing diversity within graduate schools in the USA, particularly within doctoral programmes. The programme provides underrepresented undergraduate students with opportunities to learn about research and applying to graduate schools, which otherwise might not be available for these…

McNair Scholars' Science, Technology, Engineering, and Mathematics (STEM) Graduate Experience: A Pilot Study

ERIC Educational Resources Information Center

Bancroft, Senetta F.; Benson, Susan Kushner; Johnson-Whitt, Eugenia

2016-01-01

Nationally, racial and gender disparities persist in science, technology, engineering, and mathematics (STEM) disciplines. These disparities are most notable at the doctoral level and are also found in the doctoral outcomes of Ronald E. McNair Postbaccalaureate Achievement Program participants (Scholars) despite opportunities designed to promote…

Using Achievement Motivation Theory to Explain Student Participation in a Residential Leadership Learning Community

ERIC Educational Resources Information Center

Moore, Lori L.; Grabsch, Dustin K.; Rotter, Craig

2010-01-01

This study sought to examine student motives for participating in a residential leadership learning community for incoming freshmen using McClelland's Achievement Motivation Theory (McClelland, 1958, 1961). Eighty-nine students began the program in the Fall 2009 semester and were administered a single, researcher-developed instrument. Responses to…

McDonald's Recipe for Success

ERIC Educational Resources Information Center

Weinstein, Margery

2012-01-01

Who isn't familiar with McDonald's? Its golden arches are among the most recognizable brand icons in the U.S. What many are less familiar with is the methodical and distinguished learning and development that supports that brand. Training that begins by preparing employees to serve customers at the counter, and extends to programs that help…

Dynamics of the McDonnell Douglas Large Scale Dynamic Rig and Dynamic Calibration of the Rotor Balance

DOT National Transportation Integrated Search

1994-10-01

A shake test was performed on the Large Scale Dynamic Rig in the 40- by 80-Foot Wind Tunnel in support of the McDonnell Douglas Advanced Rotor Technology (MDART) Test Program. The shake test identifies the hub modes and the dynamic calibration matrix...

Medical Surveillance Technology - Clinical Looking Glass

DTIC Science & Technology

2012-10-01

0016 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER Ms Susan Mia McCroskey, Mr. Noah Geberer , Dr. Eran Bellin 5e. TASK NUMBER...Chowdhury, Soma 0-40% Edwards, Richie 25-30% Geberer , Noah 60-70% Golden, Joe 15-30% Lee, William 0-15% McCroskey, Mia 29-50% Muresan, Mircea 0

The OMLTA Yearbook: 1982.

ERIC Educational Resources Information Center

Snyder, Barbara, Ed.

The first issue of the Yearbook of the Ohio Modern Language Teachers Association presents the following articles and features: (1) "PR and the Language Program," by Nancy Humbach; (2) "Creative Play in Language Learning," by Carolann DeSelms; (3) "Foreign Language Projects for the Gifted Student," by Carol L. McKay and Martin D. McKay; (4) "A…

From the Bench to the Clinic Part 1: Martin McIntosh, Ph.D., Introduces His Lab's Immunotherapy Research | Office of Cancer Genomics

Cancer.gov

The field of immunotherapy is rapidly advancing and genomics techniques are being incorporated to add a “precision” approach. OCG spoke with two CTD2 investigators from the Fred Hutchinson Cancer Research Center (FHCRC) about new advances in immunotherapy. For the first article of this two-part series, we interviewed Martin McIntosh, Ph.D., member of the Fred Hutchinson Translational Research program and previously Program Head in Computational Biology at FHCRC/University of Washington Comprehensive Cancer Center.

A Matched Project Evaluation of Modern Programming Practices. Volume II. Scientific Report on the ASTROS Plan.

DTIC Science & Technology

1980-02-01

formula for predictinq the number of errors during system testing. The equation he presents is B V/ ECRIT where B is the number of 19 ’R , errors...expected, V is the volume, and ECRIT is "the mean number of elementary discriminations between potential errors in programming" (p. 85). E CRIT can also...prediction of delivered bugs is: "V VX 2 B = V/ ECRIT -3- 13,824 2.3 McCabe’s Complexity Metric Thomas McCabe (1976) defined complexity in relation to

Overview of an Integrated Medical System for Exploration Missions

NASA Technical Reports Server (NTRS)

Watkins, Sharmila; Rubin, David

2013-01-01

The Exploration Medical Capability (ExMC) element of the NASA Human Research Program (HRP) is charged with addressing the risk of unacceptable health and mission outcomes due to limitations of inflight medical capabilities. The Exploration Medical System Demonstration (EMSD) is a project within the ExMC element aimed at reducing this risk by improving the medical capabilities available for exploration missions. The EMSD project will demonstrate, on the ground and on ISS, the integration of several components felt to be essential to the delivery of medical care during long ]duration missions outside of low Earth orbit. The components of the EMSD include the electronic medical record, assisted medical procedure software, medical consumables tracking technology and RFID ] tagged consumables, video conferencing capability, ultrasound device and probes (ground demonstration only), peripheral biosensors, and the software to allow communication among the various components (middleware). This presentation seeks to inform our international partners of the goals and objectives of the EMSD and to foster collaboration opportunities related to this and future projects.

Waste minimization/pollution prevention study of high-priority waste streams

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ogle, R.B.

1994-03-01

Although waste minimization has been practiced by the Metals and Ceramics (M&C) Division in the past, the effort has not been uniform or formalized. To establish the groundwork for continuous improvement, the Division Director initiated a more formalized waste minimization and pollution prevention program. Formalization of the division`s pollution prevention efforts in fiscal year (FY) 1993 was initiated by a more concerted effort to determine the status of waste generation from division activities. The goal for this effort was to reduce or minimize the wastes identified as having the greatest impact on human health, the environment, and costs. Two broadmore » categories of division wastes were identified as solid/liquid wastes and those relating to energy use (primarily electricity and steam). This report presents information on the nonradioactive solid and liquid wastes generated by division activities. More specifically, the information presented was generated by teams of M&C staff members empowered by the Division Director to study specific waste streams.« less

Analysis of Parent, Teacher, and Consultant Speech Exchanges and Educational Outcomes of Students With Autism During COMPASS Consultation.

PubMed

Ruble, Lisa; Birdwhistell, Jessie; Toland, Michael D; McGrew, John H

2011-01-01

The significant increase in the numbers of students with autism combined with the need for better trained teachers (National Research Council, 2001) call for research on the effectiveness of alternative methods, such as consultation, that have the potential to improve service delivery. Data from 2 randomized controlled single-blind trials indicate that an autism-specific consultation planning framework known as the collaborative model for promoting competence and success (COMPASS) is effective in increasing child Individual Education Programs (IEP) outcomes (Ruble, Dal-rymple, & McGrew, 2010; Ruble, McGrew, & Toland, 2011). In this study, we describe the verbal interactions, defined as speech acts and speech act exchanges that take place during COMPASS consultation, and examine the associations between speech exchanges and child outcomes. We applied the Psychosocial Processes Coding Scheme (Leaper, 1991) to code speech acts. Speech act exchanges were overwhelmingly affiliative, failed to show statistically significant relationships with child IEP outcomes and teacher adherence, but did correlate positively with IEP quality.

Analysis of Parent, Teacher, and Consultant Speech Exchanges and Educational Outcomes of Students With Autism During COMPASS Consultation

PubMed Central

RUBLE, LISA; BIRDWHISTELL, JESSIE; TOLAND, MICHAEL D.; MCGREW, JOHN H.

2011-01-01

The significant increase in the numbers of students with autism combined with the need for better trained teachers (National Research Council, 2001) call for research on the effectiveness of alternative methods, such as consultation, that have the potential to improve service delivery. Data from 2 randomized controlled single-blind trials indicate that an autism-specific consultation planning framework known as the collaborative model for promoting competence and success (COMPASS) is effective in increasing child Individual Education Programs (IEP) outcomes (Ruble, Dal-rymple, & McGrew, 2010; Ruble, McGrew, & Toland, 2011). In this study, we describe the verbal interactions, defined as speech acts and speech act exchanges that take place during COMPASS consultation, and examine the associations between speech exchanges and child outcomes. We applied the Psychosocial Processes Coding Scheme (Leaper, 1991) to code speech acts. Speech act exchanges were overwhelmingly affiliative, failed to show statistically significant relationships with child IEP outcomes and teacher adherence, but did correlate positively with IEP quality. PMID:22639523

Improving the capability of an integrated CA-Markov model to simulate spatio-temporal urban growth trends using an Analytical Hierarchy Process and Frequency Ratio

NASA Astrophysics Data System (ADS)

Aburas, Maher Milad; Ho, Yuek Ming; Ramli, Mohammad Firuz; Ash'aari, Zulfa Hanan

2017-07-01

The creation of an accurate simulation of future urban growth is considered one of the most important challenges in urban studies that involve spatial modeling. The purpose of this study is to improve the simulation capability of an integrated CA-Markov Chain (CA-MC) model using CA-MC based on the Analytical Hierarchy Process (AHP) and CA-MC based on Frequency Ratio (FR), both applied in Seremban, Malaysia, as well as to compare the performance and accuracy between the traditional and hybrid models. Various physical, socio-economic, utilities, and environmental criteria were used as predictors, including elevation, slope, soil texture, population density, distance to commercial area, distance to educational area, distance to residential area, distance to industrial area, distance to roads, distance to highway, distance to railway, distance to power line, distance to stream, and land cover. For calibration, three models were applied to simulate urban growth trends in 2010; the actual data of 2010 were used for model validation utilizing the Relative Operating Characteristic (ROC) and Kappa coefficient methods Consequently, future urban growth maps of 2020 and 2030 were created. The validation findings confirm that the integration of the CA-MC model with the FR model and employing the significant driving force of urban growth in the simulation process have resulted in the improved simulation capability of the CA-MC model. This study has provided a novel approach for improving the CA-MC model based on FR, which will provide powerful support to planners and decision-makers in the development of future sustainable urban planning.

METACASPASE9 modulates autophagy to confine cell death to the target cells during Arabidopsis vascular xylem differentiation

PubMed Central

Escamez, Sacha; André, Domenique; Zhang, Bo; Bollhöner, Benjamin; Pesquet, Edouard; Tuominen, Hannele

2016-01-01

ABSTRACT We uncovered that the level of autophagy in plant cells undergoing programmed cell death determines the fate of the surrounding cells. Our approach consisted of using Arabidopsis thaliana cell cultures capable of differentiating into two different cell types: vascular tracheary elements (TEs) that undergo programmed cell death (PCD) and protoplast autolysis, and parenchymatic non-TEs that remain alive. The TE cell type displayed higher levels of autophagy when expression of the TE-specific METACASPASE9 (MC9) was reduced using RNAi (MC9-RNAi). Misregulation of autophagy in the MC9-RNAi TEs coincided with ectopic death of the non-TEs, implying the existence of an autophagy-dependent intercellular signalling from within the TEs towards the non-TEs. Viability of the non-TEs was restored when AUTOPHAGY2 (ATG2) was downregulated specifically in MC9-RNAi TEs, demonstrating the importance of autophagy in the spatial confinement of cell death. Our results suggest that other eukaryotic cells undergoing PCD might also need to tightly regulate their level of autophagy to avoid detrimental consequences for the surrounding cells. PMID:26740571

McKenzie River Focus Watershed Coordination: Year-End Report 2000.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thrailkil, Jim

2000-01-01

This report summarizes accomplishments of the McKenzie River Focus Watershed Council (MWC) in the areas of coordination and administration during Fiscal Year 2000. Coordination and administration consist of prioritization and planning for projects; project management and implementation; procurement of funding for long-term support of the Council; and watershed education/outreach program for residents and local schools. Key accomplishments in the area of project planning include coordinating: monthly Council and executive committee meetings; staffing the Upper Willamette Spring Chinook Working Group; staffing the water quality technical committee; and guiding education and stewardship projects. Key accomplishments in the area of project management includemore » the completion of the McKenzie-Willamette Confluence Assessment; securing funds for project planning in the confluence area; near completion of the BPA funded McKenzie sub-basin assessment; development of a framework for a McKenzie Watershed Conservation Strategy; an evaluation of Council's monitoring programs - ambient water quality, storm-event water quality, Tier III water quality, and macroinvertebrate monitoring. The Council, in cooperation with the McKenzie River Cooperative, completed habitat enhancements in the Gate Creek and Deer Creek sub-watersheds. This partnership recently submitted Bring Back the Natives grant for initiation of projects in other McKenzie tributaries. The Council will also be working with a local business to develop a river-side riparian enhancement and native landscaping project on the lodge grounds. This will serve as a demonstration project for blending fish and wildlife habitat concerns with maintaining grounds for business opportunities. Accomplishments in the area of procurement of funding included developing the FY2000 Scope of Work and budget for approval by the Council and BPA; providing quarterly budget and work program progress reports to the Council; and securing additional funding from Council partner organizations and foundations. Highlights in the area of watershed education/outreach include the MWC's lead role in convening the Watershed Education Network for teachers as part of its educational mission; production of newsletters and brochures; and coordination of media coverage of watershed-related issues.« less

75 FR 70895 - Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-19

... number. Foreign Agricultural Service Title: Food Donation Programs (Food for Progress & Section 416(b... through direct donations and concessional programs. USDA Food aid may be provided through four program... programs are under 7 CFR part 1499, Foreign Donation Programs and 7 CFR part 1599, McGovern-Dole...

Engine System Loads Analysis Compared to Hot-Fire Data

NASA Technical Reports Server (NTRS)

Frady, Gregory P.; Jennings, John M.; Mims, Katherine; Brunty, Joseph; Christensen, Eric R.; McConnaughey, Paul R. (Technical Monitor)

2002-01-01

Early implementation of structural dynamics finite element analyses for calculation of design loads is considered common design practice for high volume manufacturing industries such as automotive and aeronautical industries. However with the rarity of rocket engine development programs starts, these tools are relatively new to the design of rocket engines. In the NASA MC-1 engine program, the focus was to reduce the cost-to-weight ratio. The techniques for structural dynamics analysis practices, were tailored in this program to meet both production and structural design goals. Perturbation of rocket engine design parameters resulted in a number of MC-1 load cycles necessary to characterize the impact due to mass and stiffness changes. Evolution of loads and load extraction methodologies, parametric considerations and a discussion of load path sensitivities are important during the design and integration of a new engine system. During the final stages of development, it is important to verify the results of an engine system model to determine the validity of the results. During the final stages of the MC-1 program, hot-fire test results were obtained and compared to the structural design loads calculated by the engine system model. These comparisons are presented in this paper.

Marie McMahan: AECT President 1978-1979

ERIC Educational Resources Information Center

Audiovisual Instruction, 1978

1978-01-01

The 1978-79 president, Marie McMahan, discusses a model of the interrelationships of the diverse groups within the association for the future improvement of communications, involvement, and professional preparation within AECT. (CMV)

Downregulation of mucosal mast cell activation and immune response in diarrhoea-irritable bowel syndrome by oral disodium cromoglycate: A pilot study

PubMed Central

Lobo, Beatriz; Ramos, Laura; Martínez, Cristina; Guilarte, Mar; González-Castro, Ana M; Alonso-Cotoner, Carmen; Pigrau, Marc; de Torres, Inés; Rodiño-Janeiro, Bruno K; Salvo-Romero, Eloisa; Fortea, Marina; Pardo-Camacho, Cristina; Guagnozzi, Danila; Azpiroz, Fernando

2017-01-01

Background and goal Diarrhoea-predominant irritable bowel syndrome (IBS-D) exhibits intestinal innate immune and mucosal mast cell (MC) activation. MC stabilisers have been shown to improve IBS symptoms but the mechanism is unclear. Our primary aim was to investigate the effect of oral disodium cromoglycate (DSCG) on jejunal MC activation and specific innate immune signalling pathways in IBS-D, and secondarily, its potential clinical benefit. Study Mucosal MC activation (by ultrastructural changes, tryptase release and gene expression) and innate immune signalling (by protein and gene expression) were quantified in jejunal biopsies from healthy (HS; n = 16) and IBS-D subjects after six months of either treatment with DSCG (600 mg/day, IBS-D-DSCG group; n = 18) or without treatment (IBS-D-NT group; n = 25). All IBS-D patients recorded abdominal pain and bowel habits at baseline and in the last 10 days prior to jejunal sampling. Results IBS-D-NT exhibited significant MC activation and over-expression of immune-related genes as compared to HS, whereas in IBS-D-DSCG MC activity and gene expression were similar to HS. Furthermore, DSCG significantly reduced abdominal pain and improved stool consistency. Conclusion Oral DSCG modulates mucosal immune activity and improves gut symptoms in IBS-D patients. Future placebo-controlled clinical trials are needed for confirmation of clinical benefit of DSCG for IBS-D. PMID:29026603

The Human Side of Science Education: Using McGregor's Theory Y as a Framework for Improving Student Motivation

ERIC Educational Resources Information Center

Markwell, John

2004-01-01

Student motivation is correlated with learning. Douglas McGregor's Theory X and Theory Y as a basis for understanding and improving motivation in the business world can be directly applied to the science classroom. Teachers with a Theory Y perspective (students naturally want to learn) provide increased motivation for students and promote more…

McDonnell FH-1 Phantom Destroyed for the NACA Crash Fire Program

NASA Image and Video Library

1955-04-21

Researchers at the National Advisory Committee for Aeronautics (NACA) Lewis Flight Propulsion Laboratory purposely wreck a McDonnell FH-1 Phantom as part of the laboratory’s Crash Fire Program. NACA Lewis researchers created the program in 1949 to investigate methods for improving survival rates for take-off and landing-type crashes. In these types of crashes, the passengers often survived the impact only to perish in the ensuing fire. Previously there had been little information on the nature of post-crash fires, and it was difficult to use analytical studies in this area. Irving Pinkel, Chief of the Lewis Flight Propulsion Division, was the primary researcher. He enlisted flight safety specialist and aeronautics researchers G. Merritt Preston and Gerard Pesman, mechanical engineer Dugald Black, and others. The tests were conducted at the nearby Ravenna Arsenal using decommissioned Air Force fighter and transport aircraft. The pilotless aircraft were accelerated down a rail on a 1700-foot track at take-off speeds and run into barriers to simulate a variety of different types of crashes. The first barrier stripped off the landing gears and another briefly sent the aircraft off the ground before it crashed into a dirt mound. Telemetry and high-speed cameras were crucial elements in these studies. NACA Lewis photographer Bill Wynne developed a method for inserting timekeeping devices on test film that were able to show time to one thousandth of a second.

25 CFR 115.818 - What happens if an Indian adult does not cash his or her per capita check?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false What happens if an Indian adult does not cash his or her... Funds § 115.818 What happens if an Indian adult does not cash his or her per capita check? (a) If an Indian adult does not cash his or her per capita check within twelve (12) months of the date the check...

25 CFR 115.818 - What happens if an Indian adult does not cash his or her per capita check?

Code of Federal Regulations, 2012 CFR

2012-04-01

... 25 Indians 1 2012-04-01 2011-04-01 true What happens if an Indian adult does not cash his or her... Funds § 115.818 What happens if an Indian adult does not cash his or her per capita check? (a) If an Indian adult does not cash his or her per capita check within twelve (12) months of the date the check...

25 CFR 115.818 - What happens if an Indian adult does not cash his or her per capita check?

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 1 2014-04-01 2014-04-01 false What happens if an Indian adult does not cash his or her... Funds § 115.818 What happens if an Indian adult does not cash his or her per capita check? (a) If an Indian adult does not cash his or her per capita check within twelve (12) months of the date the check...

25 CFR 115.818 - What happens if an Indian adult does not cash his or her per capita check?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 25 Indians 1 2011-04-01 2011-04-01 false What happens if an Indian adult does not cash his or her... Funds § 115.818 What happens if an Indian adult does not cash his or her per capita check? (a) If an Indian adult does not cash his or her per capita check within twelve (12) months of the date the check...

25 CFR 115.818 - What happens if an Indian adult does not cash his or her per capita check?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 1 2013-04-01 2013-04-01 false What happens if an Indian adult does not cash his or her... Funds § 115.818 What happens if an Indian adult does not cash his or her per capita check? (a) If an Indian adult does not cash his or her per capita check within twelve (12) months of the date the check...

Educating Homeless Youth in Texas: The McKinney-Vento Homeless Education Assistance Improvements Act of 2001.

PubMed

Windsor, Liliane Cambraia; Thompson, Sanna J

2008-07-01

This paper discusses homeless youth in the US focusing on educational issues addressed by the implementation of the McKinney-Vento Homeless Education Assistance Improvements Act of 2001. This law requires that states ensure each homeless child has equal access to public education. Moreover, the law requires states to identify and remove barriers to homeless children's education, such as requirements for previous school records and proof of residency. Following description of homelessness, educational issues, and barriers for homeless youth, the McKinney-Vento Act is described as it is applied in Texas. Finally, the paper concludes that further development, education, and commitment from service providers in schools and other community agencies will be needed to improve outcomes for these highly vulnerable youth.

Patterns of Radicalization: Identifying the Markers and Warning Signs of Domestic Lone Wolf Terrorists in Our Midst

DTIC Science & Technology

2009-12-01

effect the general education program had on students like him. Gen Ed delivered to those of us who were undergraduates during this time a double...were not very important to McVeigh, although he was one of the brightest students in his school. “McVeigh was a bright (IQ 128, above average...hardworking student who got sloppy at times but earned mostly As and Bs through high school, falling just outside the top 20% of his class.”37 McVeigh’s

Proposed Tier 2 Screening Criteria and Tier 3 Field Procedures for Evaluation of Vapor Intrusion (ESTCP Cost and Performance Report)

DTIC Science & Technology

2012-08-01

Interstate Technology & Regulatory Council, Washington, DC, Copyright 2007. McHugh T.E., D.E. Hammond, T. Nickels , and B. Hartman. 2008. Use of...based corrective action have realized significant cost savings for their corrective action programs (Connor and McHugh , 2002). As described above...Groundwater (Tier 2) VOCs USEPA 8260B 40 mL VOA vial HCl 14 days Vapor (Tier 2 and Tier 3) Radon McHugh et al., 2008 500 mL Tedlar bag None 14

Synaptic plasticity and sensory-motor improvement following fibrin sealant dorsal root reimplantation and mononuclear cell therapy

PubMed Central

Benitez, Suzana U.; Barbizan, Roberta; Spejo, Aline B.; Ferreira, Rui S.; Barraviera, Benedito; Góes, Alfredo M.; de Oliveira, Alexandre L. R.

2014-01-01

Root lesions may affect both dorsal and ventral roots. However, due to the possibility of generating further inflammation and neuropathic pain, surgical procedures do not prioritize the repair of the afferent component. The loss of such sensorial input directly disturbs the spinal circuits thus affecting the functionality of the injuried limb. The present study evaluated the motor and sensory improvement following dorsal root reimplantation with fibrin sealant (FS) plus bone marrow mononuclear cells (MC) after dorsal rhizotomy. MC were used to enhance the repair process. We also analyzed changes in the glial response and synaptic circuits within the spinal cord. Female Lewis rats (6–8 weeks old) were divided in three groups: rhizotomy (RZ group), rhizotomy repaired with FS (RZ+FS group) and rhizotomy repaired with FS and MC (RZ+FS+MC group). The behavioral tests electronic von-Frey and Walking track test were carried out. For immunohistochemistry we used markers to detect different synapse profiles as well as glial reaction. The behavioral results showed a significant decrease in sensory and motor function after lesion. The reimplantation decreased glial reaction and improved synaptic plasticity of afferent inputs. Cell therapy further enhanced the rewiring process. In addition, both reimplanted groups presented twice as much motor control compared to the non-treated group. In conclusion, the reimplantation with FS and MC is efficient and may be considered an approach to improve sensory-motor recovery following dorsal rhizotomy. PMID:25249946

Adaptive Transmission and Channel Modeling for Frequency Hopping Communications

DTIC Science & Technology

2009-09-21

proposed adaptive transmission method has much greater system capacity than conventional non-adaptive MC direct- sequence ( DS )- CDMA system. • We...several mobile radio systems. First, a new improved allocation algorithm was proposed for multicarrier code-division multiple access (MC- CDMA ) system...Multicarrier code-division multiple access (MC- CDMA ) system with adaptive frequency hopping (AFH) has attracted attention of researchers due to its

Leveraging Air Force Medical Service (AFMS) Senior Leadership Corps Diversity to Improve Efficiency

DTIC Science & Technology

2013-04-01

licensing , and board certification requirements . A few of these specialties include physician assistant, physical therapist, optometrist, podiatrist...the Deputy Surgeon General (MC), the AFMS Family Practice consultant (MC), 5 Family Practice physicians (MC), 2 nurses (NC), 2 medical technicians...specifically require clinicians, instead of taking advantage of their valuable clinical training in the MTFs. To illustrate, moving one family practice

Mountains to Climb: A Union-Led Partnership to Revitalize Education in McDowell County, West Virginia

ERIC Educational Resources Information Center

Dubin, Jennifer

2016-01-01

For more than four years, the AFT has guided the efforts of a public-private partnership to bring much-needed resources and services to McDowell County, West Virginia, a geographically isolated area in the heart of Appalachia. Known as Reconnecting McDowell, the initiative has also encouraged a renewed emphasis on improving education by focusing…

Photocatalytic Removal of Microcystin-LR by Advanced WO3-Based Nanoparticles under Simulated Solar Light

PubMed Central

Zhao, Chao; Li, Dawei; Feng, Chuanping; Zhang, Zhenya; Sugiura, Norio; Yang, Yingnan

2015-01-01

A series of advanced WO3-based photocatalysts including CuO/WO3, Pd/WO3, and Pt/WO3 were synthesized for the photocatalytic removal of microcystin-LR (MC-LR) under simulated solar light. In the present study, Pt/WO3 exhibited the best performance for the photocatalytic degradation of MC-LR. The MC-LR degradation can be described by pseudo-first-order kinetic model. Chloride ion (Cl−) with proper concentration could enhance the MC-LR degradation. The presence of metal cations (Cu2+ and Fe3+) improved the photocatalytic degradation of MC-LR. This study suggests that Pt/WO3 photocatalytic oxidation under solar light is a promising option for the purification of water containing MC-LR. PMID:25884038

The Nordic maintenance care program: what is maintenance care? Interview based survey of Danish chiropractors

PubMed Central

2013-01-01

Objective To describe and interpret Danish Chiropractors’ perspectives regarding the purpose and rationale for using MC (maintenance care), its content, course and patient characteristics. Methods Semi-structured interviews were conducted with 10 chiropractors identified using a stratified, theoretical sampling framework. Interviews covered four domains relating to MC, namely: purpose, patient characteristics, content, and course and development. Data was analysed thematically. Results Practitioners regard MC primarily as a means of providing secondary or tertiary care and they primarily recommend it to patients with a history of recurrence. Initiating MC is often a shared decision between clinician and patient. The core elements of MC are examination and manipulation, but exercise and general lifestyle advice are often included. Typically, treatment intervals lie between 2 and 4 months. Clinician MC practices seem to evolve over time and are informed by individual practice experiences. Chiropractors are more likely to offer MC to patients whose complaints include a significant muscular component. Furthermore, a successful transition to MC appears dependent on correctly matching complaint with management. A positive relationship between chiropractor and patient facilitates the initiation of MC. Finally; MC appears grounded in a patient-oriented approach to care rather than a market-oriented one. Conclusion MC is perceived as both a secondary and tertiary preventative measure and its practice appears grounded in the tenet of patient-oriented care. A positive personal relationship between chiropractor and patient facilitates the initiation of MC. The results from this and previous studies should be considered in the design of studies of efficacy. PMID:23962318

Home fire safety intervention pilot with urban older adults living in Wales.

PubMed

Lehna, Carlee; Merrell, Joy; Furmanek, Stephen; Twyman, Stephanie

2017-02-01

The purpose of this pilot study was to evaluate the effects of a home fire safety (HFS) education program developed in the US, on improved HFS knowledge and practice in a purposive sample of 12 urban older adults living in Swansea, Wales. Knowledge was tested at baseline (T1), immediately after watching a Video on HFS (T2), and at 2-week follow-up (T3). A majority of the participants were Caucasian (n=9, 81.8%), and female (n=11, 91.7%); their mean age was 78years old (SD=12.7years). They had two chronic illnesses (n=1.8, SD=1.3), walked without help (n=7, 58.3%), and lived in a flat (n=10, 90.9%). Knowledge scores (percent correct) changed over time and were significantly different from T1 (46.7%) to T2 (59.2%, p=0.04) and from T1 (46.7%) to T3 (58.9%, p=0.04), but T2 and T3 (p=0.94) scores showed no difference. There is a need for educational HFS intervention programs aimed at this age group. This pilot successfully targeted active older adults living independently in sheltered housing complexes. Further fire safety research is needed with community dwelling older adults living in other types of housing. Copyright © 2016 Elsevier Ltd and ISBI. All rights reserved.

The timber resources of Kentucky

Treesearch

David A. Gansner

1968-01-01

The McSweeney-McNary Forest Research Act of 1928 authorizes the U. S. Forest Service to complete a statewide forest inventory of Kentucky at approximate 10-year intervals as part of the nationwide program of maintaining a current account of our timber resources. The Division of Forestry of the Kentucky Department of Natural Resources and the U. S. Forest Service...

"Win with Katie McGee": The First Governor of Girls' State Looks Back.

ERIC Educational Resources Information Center

Harsh, Sarah Wilmoth

2003-01-01

Rhododendron Girls' State, a 5-day West Virginia citizenship and leadership program, offers female high school students the opportunity to directly experience the campaign and electoral process. Katie McGee White discusses her experiences as the first Girls' State governor in 1941, her love of politics, and how she encouraged her students to be…

Development of an Effectiveness Model or Metric for the Air Force Environmental Compliance Assessment and Management Program (ECAMP)

DTIC Science & Technology

1993-09-01

Regional Compliance Office, San Francisco CA, 19 February 1993. 8. Brunner, Paul G. "Organizing For Environmental Compliance at McClellan AFB," Federal...Probability and Statistics, Schaums Outline Series. New York: McGraw Hill, 1992. 42. Vergara , Capt Gwen. Chief, ECAMP Policy and Oversight Division

House Hearing Nunn-McCurdy Review of NPOESS

NASA Image and Video Library

2006-06-08

NASA Administrator Michael Griffin, testifies before the House Committee on Science and Technology regarding the future of the National Polar-orbiting Operational Environmental Satellite System (NPOESS) and results of the Nunn-McCurdy review of NOAA’s weather satellite program, Thursday, June 8, 2006, at the Rayburn House Office Building in Washington. Photo Credit: (NASA/Bill Ingalls)

Student Responsibility and Self-Directed Learning: An Interview with Christine Mcphail

ERIC Educational Resources Information Center

Saxon, D. Patrick

2013-01-01

Christine McPhail formerly served as president at Cypress College in California and is founder and professor emeritus of the Community College Leadership Doctoral Program at Morgan State University in Maryland. She is the Managing Partner for The McPhail Group LLC and currently serves as a Leadership Coach for more than a dozen community colleges…

The Lived Intersectional Experiences of Privilege and Oppression of Queer Men of Color in Counselor Education Doctoral Programs: An Interpretative Phenomenological Analysis

ERIC Educational Resources Information Center

Chan, Christian D.

2018-01-01

The advent of the "Multicultural and Social Justice Counseling Competencies" (Ratts, Singh, Nassar-McMillan, Butler, & McCullough, 2016), the "American Counseling Association (ACA) Code of Ethics" (2014), and a more comprehensive emphasis on multiculturalism and social justice (Haskins & Singh, 2015; Ratts, 2009, 2011;…

Advanced Rotorcraft Transmission (ART) program

NASA Technical Reports Server (NTRS)

Heath, Gregory F.; Bossler, Robert B., Jr.

1993-01-01

Work performed by the McDonnell Douglas Helicopter Company and Lucas Western, Inc. within the U.S. Army/NASA Advanced Rotorcraft Transmission (ART) Program is summarized. The design of a 5000 horsepower transmission for a next generation advanced attack helicopter is described. Government goals for the program were to define technology and detail design the ART to meet, as a minimum, a weight reduction of 25 percent, an internal noise reduction of 10 dB plus a mean-time-between-removal (MTBR) of 5000 hours compared to a state-of-the-art baseline transmission. The split-torque transmission developed using face gears achieved a 40 percent weight reduction, a 9.6 dB noise reduction and a 5270 hour MTBR in meeting or exceeding the above goals. Aircraft mission performance and cost improvements resulting from installation of the ART would include a 17 to 22 percent improvement in loss-exchange ratio during combat, a 22 percent improvement in mean-time-between-failure, a transmission acquisition cost savings of 23 percent of $165K, per unit, and an average transmission direct operating cost savings of 33 percent, or $24K per flight hour. Face gear tests performed successfully at NASA Lewis are summarized. Also, program results of advanced material tooth scoring tests, single tooth bending tests, Charpy impact energy tests, compact tension fracture toughness tests and tensile strength tests are summarized.

Efficacy of Hip Strengthening Exercises Compared With Leg Strengthening Exercises on Knee Pain, Function, and Quality of Life in Patients With Knee Osteoarthritis.

PubMed

Lun, Victor; Marsh, Andrew; Bray, Robert; Lindsay, David; Wiley, Preston

2015-11-01

The purpose of this study was to compare the efficacy of hip and leg strengthening exercise programs on knee pain, function, and quality of life (QOL) of patients with knee osteoarthritis (KOA). Single-Blinded Randomized Clinical Trial. Patients with KOA. Male and female subjects were recruited from patients referred to the University of Calgary Sport Medicine Center and from newspaper advertisements. Thirty-seven and 35 patients with KOA were randomly assigned to either a 12-week hip or leg strengthening exercise program, respectively. Both exercise programs consisted of strengthening and flexibility exercises, which were completed 3 to 5 days a week. The first 3 weeks of exercise were supervised and the remaining 9 weeks consisted of at-home exercise. Knee Injury and Osteoarthritis Score (KOOS) and Western Ontario McMaster Arthritis Index (WOMAC) questionnaires, 6-minute walk test, hip and knee range of motion (ROM), and hip and leg muscle strength. Statistically and clinically significant improvements in the KOOS and WOMAC pain subscale scores were observed in both the hip and leg strengthening programs. There was no statistical difference in the change in scores observed between the 2 groups. Equal improvements in the KOOS and WOMAC function and QOL subscales were observed for both programs. There was no change in hip and knee ROM or hip and leg strength in either group. Isolated hip and leg strengthening exercise programs seem to similarly improve knee pain, function, and QOL in patients with KOA. The results of this study show that both hip and leg strengthening exercises improve pain and QOL in patients with KOA and should be incorporated into the exercise prescription of patients with KOA.

A retrospective analysis of chemotherapy switch suggests improved outcome in surgically removed, biologically aggressive canine haemangiosarcoma.

PubMed

Finotello, R; Henriques, J; Sabattini, S; Stefanello, D; Felisberto, R; Pizzoni, S; Ferrari, R; Marconato, L

2017-06-01

Haemangiosarcoma (HSA) has an aggressive biological behaviour and carries a poor prognosis, with less than 10% of treated dogs surviving longer than 1 year. In this retrospective study a varied metronomic chemotherapy (MC) regimen preceded by adjuvant doxorubicin-based maximum-tolerated dose chemotherapy (MTDC) was compared with MTDC, in terms of efficacy [time to metastasis, (TTM) and survival time (ST)] and safety in dogs with biologically aggressive HSA. Dogs were eligible if they had no metastasis after MTDC and received either no further chemotherapy or MC maintenance. Twelve dogs received MTDC, and 10 received MC thereafter. Median TTM and ST were significantly longer for dogs receiving MTDC-MC (not reached versus 150 days, P = 0.028; and not reached versus 168 days, P = 0.030, respectively). Treatment was well tolerated. MTDC followed by MC is safe and suggests improved TTM and ST in dogs with surgically removed, biologically aggressive HSA that are treated in the microscopic setting. © 2016 John Wiley & Sons Ltd.

STS-54 Pilot McMonagle with DSO 802 & Physics of Toys top on OV-105's middeck

NASA Image and Video Library

1993-01-15

STS054-S-020 (15 Jan 1993) --- McMonagle watches as a top spins above his head on the middeck of the Earth-orbiting Endeavour. The demonstration was part of a lengthy "physics of toys" program conducted by all five crewmembers on their third day aboard the Shuttle. Through telephone and TV downlinks, students in four schools around the country participated in a special lesson to discover how specific toys function differently in the classroom compared to those on the Shuttle. Students at Westwood Elementary School in Flint, Michigan -- McMonagle's hometown -- asked him questions about the several toys he demonstrated. The top demonstrates gyroscopic motion, the center of mass and angular momentum. The entire collection of toys will be videotaped for an educational program to be distributed to schools in the autumn. The scene was downlinked at 18:01:59:11 GMT, Jan. 15, 1993.

One session treatment for pediatric blood-injection-injury phobia: A controlled multiple baseline trial.

PubMed

Oar, Ella L; Farrell, Lara J; Waters, Allison M; Conlon, Elizabeth G; Ollendick, Thomas H

2015-10-01

The present study evaluated the effectiveness of a modified One Session Treatment (OST), which included an e-therapy homework maintenance program over 4 weeks for Blood-Injection-Injury (BII) phobia in children and adolescents. Using a single case, non-concurrent multiple-baseline design, 24 children and adolescents (8-18 years; 7 males, 17 females) with a primary diagnosis of BII phobia were randomly assigned to a one, two or three week baseline prior to receiving OST. Primary outcome measures included diagnostic severity, diagnostic status, and child and parent fear ratings. Secondary outcome measures included avoidance during behavioural avoidance tasks (BAT), global functioning and self and parent reported anxiety, fear and depression. Efficacy was assessed at post-treatment, 1-month, and 3-month follow-up. BII symptoms and diagnostic severity remained relatively stable during the baseline periods and then significantly improved following implementation of the intervention. Treatment response was supported by changes across multiple measures, including child, parent and independent clinician ratings. At post-treatment 8 of the 24 (33.33%) children were BII diagnosis free. Treatment gains improved at follow-ups with 14 (58.33%) children diagnosis free at 1-month follow-up and 15 (62.5%) diagnosis free at 3-month follow-up. Preliminary findings support the effectiveness of a modified OST approach for BII phobic youth with treatment outcomes improving over follow-up intervals. Copyright © 2015 Elsevier Ltd. All rights reserved.

Application of ground-penetrating radar at McMurdo Station, Antarctica

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stefano, J.E.

1992-05-01

Argonne National Laboratory initiated a site investigation program at McMurdo Station, Antarctica, to characterize environmental contamination. The performance and usefulness of ground-penetrating radar (GPR) was evaluated under antarctic conditions during the initial site investigation in January 1991. Preliminary surveys were successful in defining the contact between reworked pyroclastic material and in the prefill, undisturbed pyroclastics and basalts at some sites. Interference from radio traffic at McMurdo Station was not observed, but interference was a problem in work with unshielded antennas near buildings. In general, the results of this field test suggest that high-quality, high-resolution, continuous subsurface profiles can be producedmore » with GPR over most of McMurdo Station.« less

Application of ground-penetrating radar at McMurdo Station, Antarctica

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stefano, J.E.

1992-01-01

Argonne National Laboratory initiated a site investigation program at McMurdo Station, Antarctica, to characterize environmental contamination. The performance and usefulness of ground-penetrating radar (GPR) was evaluated under antarctic conditions during the initial site investigation in January 1991. Preliminary surveys were successful in defining the contact between reworked pyroclastic material and in the prefill, undisturbed pyroclastics and basalts at some sites. Interference from radio traffic at McMurdo Station was not observed, but interference was a problem in work with unshielded antennas near buildings. In general, the results of this field test suggest that high-quality, high-resolution, continuous subsurface profiles can be producedmore » with GPR over most of McMurdo Station.« less

CRISPR/Cas9/sgRNA-mediated targeted gene modification confirms the cause-effect relationship between gyrA mutation and quinolone resistance in Escherichia coli.

PubMed

Qiu, Haixiang; Gong, Jiansen; Butaye, Patrick; Lu, Guangwu; Huang, Ke; Zhu, Guoqiang; Zhang, Jilei; Hathcock, Terri; Cheng, Darong; Wang, Chengming

2018-05-14

Quinolones are broad-spectrum antibiotics that have been used for decades in treating bacterial infections in humans and animals, and subsequently bacterial resistance to these agents has increased. While studies indicated the relationship between gyrA mutations and bacterial resistance to quinolones, CRISPR/Cas9 was used in this study to investigate causal role of gyrA mutation in the quinolone resistance. In this study, 818 clinical Escherichia coli isolates were analyzed for gyrA mutations and their resistance to quinolones. The CRISPR/Cas9 system was used to generate gyrA mutations in quinolone-susceptible E. coli ATCC 25922, and quinolone-resistant clinical E. coli. The antimicrobial resistance prevalence rate in E. coli against nalidixic acid, ciprofloxacin and enrofloxacin was 77.1% (631/818), 51.1% (418/818) and 49.8% (407/818), respectively. The gyrA mutations were identified in nucleotide positions 248, 255, 259, 260, 261, 273 and 300, and mutations at positions 248 and 259 resulting in amino acid changes at positions 83 and 87 were associated with quinolone resistance. Double-site amino acid mutations increase resistance to quinolones. The gyrA mutations causing changes at amino acids 83 and 87 reversed the features of quinolone resistance in ATCC and clinical strains, verifying the causal role of gyrA mutation in the quinolone resistance of E. coli.

Sampling Enrichment toward Target Structures Using Hybrid Molecular Dynamics-Monte Carlo Simulations

PubMed Central

Yang, Kecheng; Różycki, Bartosz; Cui, Fengchao; Shi, Ce; Chen, Wenduo; Li, Yunqi

2016-01-01

Sampling enrichment toward a target state, an analogue of the improvement of sampling efficiency (SE), is critical in both the refinement of protein structures and the generation of near-native structure ensembles for the exploration of structure-function relationships. We developed a hybrid molecular dynamics (MD)-Monte Carlo (MC) approach to enrich the sampling toward the target structures. In this approach, the higher SE is achieved by perturbing the conventional MD simulations with a MC structure-acceptance judgment, which is based on the coincidence degree of small angle x-ray scattering (SAXS) intensity profiles between the simulation structures and the target structure. We found that the hybrid simulations could significantly improve SE by making the top-ranked models much closer to the target structures both in the secondary and tertiary structures. Specifically, for the 20 mono-residue peptides, when the initial structures had the root-mean-squared deviation (RMSD) from the target structure smaller than 7 Å, the hybrid MD-MC simulations afforded, on average, 0.83 Å and 1.73 Å in RMSD closer to the target than the parallel MD simulations at 310K and 370K, respectively. Meanwhile, the average SE values are also increased by 13.2% and 15.7%. The enrichment of sampling becomes more significant when the target states are gradually detectable in the MD-MC simulations in comparison with the parallel MD simulations, and provide >200% improvement in SE. We also performed a test of the hybrid MD-MC approach in the real protein system, the results showed that the SE for 3 out of 5 real proteins are improved. Overall, this work presents an efficient way of utilizing solution SAXS to improve protein structure prediction and refinement, as well as the generation of near native structures for function annotation. PMID:27227775

Sampling Enrichment toward Target Structures Using Hybrid Molecular Dynamics-Monte Carlo Simulations.

PubMed

Yang, Kecheng; Różycki, Bartosz; Cui, Fengchao; Shi, Ce; Chen, Wenduo; Li, Yunqi

2016-01-01

Sampling enrichment toward a target state, an analogue of the improvement of sampling efficiency (SE), is critical in both the refinement of protein structures and the generation of near-native structure ensembles for the exploration of structure-function relationships. We developed a hybrid molecular dynamics (MD)-Monte Carlo (MC) approach to enrich the sampling toward the target structures. In this approach, the higher SE is achieved by perturbing the conventional MD simulations with a MC structure-acceptance judgment, which is based on the coincidence degree of small angle x-ray scattering (SAXS) intensity profiles between the simulation structures and the target structure. We found that the hybrid simulations could significantly improve SE by making the top-ranked models much closer to the target structures both in the secondary and tertiary structures. Specifically, for the 20 mono-residue peptides, when the initial structures had the root-mean-squared deviation (RMSD) from the target structure smaller than 7 Å, the hybrid MD-MC simulations afforded, on average, 0.83 Å and 1.73 Å in RMSD closer to the target than the parallel MD simulations at 310K and 370K, respectively. Meanwhile, the average SE values are also increased by 13.2% and 15.7%. The enrichment of sampling becomes more significant when the target states are gradually detectable in the MD-MC simulations in comparison with the parallel MD simulations, and provide >200% improvement in SE. We also performed a test of the hybrid MD-MC approach in the real protein system, the results showed that the SE for 3 out of 5 real proteins are improved. Overall, this work presents an efficient way of utilizing solution SAXS to improve protein structure prediction and refinement, as well as the generation of near native structures for function annotation.

CTUIR Grande Ronde River Basin Watershed Restoration Program McCoy Creek/McIntyre Creek Road Crossing, 1996-1998 Progress Report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Childs, Allen B.

1999-07-01

This Annual Report provides a detailed overview of watershed restoration accomplishments achieved by the Confederated Tribes of the Umatilla Indian Reservation (CTUIR) and project partners in the Upper Grande Ronde River Basin under contract with the Bonneville Power Administration (BPA) during the period July 1, 1997 through June 30, 1998. The Contract Agreement entitled McCoy Meadows Watershed Restoration Project (Project No.96-83-01) includes habitat restoration planning, design, and implementation in two project areas--the McCoy Meadows Ranch located in the Meadow, McCoy, and McIntyre Creek subbasins on private land and the Mainstem Grande Ronde River Habitat Enhancement Project located on private andmore » National Forest System lands near Bird Tract Springs along the Grande Ronde River. During the contract period, the CTUIR and partners (Mark and Lorna Tipperman, landowners), Oregon Department of Environmental Quality (ODEQ), U.S. Environmental Protection Agency (EPA), Oregon Department of Fish and Wildlife (ODFW), and Natural Resource Conservation Service (NRCS) initiated phase 1 construction of the McCoy Meadows Restoration Project. Phase 1 involved reintroduction of a segment of McCoy Creek from its existing channelized configuration into a historic meander channel. Project efforts included bioengineering and tree/shrub planting and protection, transporting salvaged cottonwood tree boles and limbs from offsite source to the project area for utilization by resident beaver populations for forage and dam construction materials, relocation of existing BPA/ODFW riparian corridor fencing to outer edges of meadow floodplain, establishment of pre-project photo points, and coordination of other monitoring and evaluation efforts being led by other project partners including groundwater monitoring wells, channel cross sections, water quality monitoring stations, juvenile population sampling index sites, redd surveys, and habitat surveys. Project activities also included coordination with the U.S. Forest Service, Wallowa-Whitman National Forest, LaGrande Ranger District (USFS) on the Forest Road 2137 (McIntyre Road) Relocation and Obliteration Project and the McCoy Creek crossing. The USFS completed engineering designs under the cooperative effort for the McCoy Creek crossing. Project activities accomplished on the Upper Mainstem Large Wood Addition Project included placement of approximately 120 whole trees to enhance instream structural diversity, pool habitat quality, streambank stability, and improved floodplain morphology. Project activities accomplished on the Mainstem Grande Ronde Habitat Enhancement Project included coordination with landowners (Shauna Musgrove of Cuhna Ranches, Dean Stone, and the Wallowa-Whitman National Forest, LaGrande Ranger District) to develop a habitat enhancement/restoration project opportunity along a 3 mile section of the mainstem Grande Ronde River and major tributaries including the lower reaches of Bear Creek and Jordan Creek. Upon securing an agreement with the landowners, project partners including the CTUIR, ODFW, NRCS, and USFS initiated development of project objectives and site-specific designs. By June 1998, project designs were completed and preparations nearly complete to initiate onsite project construction.« less

Constructing a mixed π-conjugated bridge to effectively enhance the nonlinear optical response in the Möbius cyclacene-based systems.

PubMed

Chen, Liwei; Yu, Guangtao; Chen, Wei; Tu, Chunyun; Zhao, Xingang; Huang, Xuri

2014-06-14

Using density functional theory computations, employing the concept of a mixed π-conjugated bridge can effectively improve the first hyperpolarizability (β0) of Möbius cyclacene (MC)-based systems with a D-π-A framework. This mixed π-conjugated bridge is constructed by applying a -(CH=CH)x-NH2 or -(CH=CH)x-NO2 chain to modify [8]MC, which can lead to a considerable β0 value (e.g. [8]MC-(CH=CH)12-NO2 (9.87 × 10(5) au) with only a certain chain length), much larger than the sole [8]MC (261 au) and the corresponding NH2/NO2-modified polyethylene chain with the same π-conjugated length. It is revealed that the substituent sites and the chain length can play a crucial role in improving β0 values of these MC-chain systems, where the β0 value can monotonically increase with increasing -(CH=CH)x- length, and the substituent electron-withdrawing -(CH=CH)x-NO2 chain is superior to the parallel electron-donating -(CH=CH)x-NH2. These appealing findings can provide valuable insights into the design of novel NLO materials based on MC.

Mast Cells Regulate Wound Healing in Diabetes

PubMed Central

Tellechea, Ana; Leal, Ermelindo C.; Kafanas, Antonios; Auster, Michael E.; Kuchibhotla, Sarada; Ostrovsky, Yana; Tecilazich, Francesco; Baltzis, Dimitrios; Zheng, Yongjun; Carvalho, Eugénia; Zabolotny, Janice M.; Weng, Zuyi; Petra, Anastasia; Patel, Arti; Panagiotidou, Smaro; Pradhan-Nabzdyk, Leena; Theoharides, Theoharis C.

2016-01-01

Diabetic foot ulceration is a severe complication of diabetes that lacks effective treatment. Mast cells (MCs) contribute to wound healing, but their role in diabetes skin complications is poorly understood. Here we show that the number of degranulated MCs is increased in unwounded forearm and foot skin of patients with diabetes and in unwounded dorsal skin of diabetic mice (P < 0.05). Conversely, postwounding MC degranulation increases in nondiabetic mice, but not in diabetic mice. Pretreatment with the MC degranulation inhibitor disodium cromoglycate rescues diabetes-associated wound-healing impairment in mice and shifts macrophages to the regenerative M2 phenotype (P < 0.05). Nevertheless, nondiabetic and diabetic mice deficient in MCs have delayed wound healing compared with their wild-type (WT) controls, implying that some MC mediator is needed for proper healing. MCs are a major source of vascular endothelial growth factor (VEGF) in mouse skin, but the level of VEGF is reduced in diabetic mouse skin, and its release from human MCs is reduced in hyperglycemic conditions. Topical treatment with the MC trigger substance P does not affect wound healing in MC-deficient mice, but improves it in WT mice. In conclusion, the presence of nondegranulated MCs in unwounded skin is required for proper wound healing, and therapies inhibiting MC degranulation could improve wound healing in diabetes. PMID:27207516

Effects of McGill stabilization exercises and conventional physiotherapy on pain, functional disability and active back range of motion in patients with chronic non-specific low back pain.

PubMed

Ghorbanpour, Arsalan; Azghani, Mahmoud Reza; Taghipour, Mohammad; Salahzadeh, Zahra; Ghaderi, Fariba; Oskouei, Ali E

2018-04-01

[Purpose] The aim of this study was to compare the effects of "McGill stabilization exercises" and "conventional physiotherapy" on pain, functional disability and active back flexion and extension range of motion in patients with chronic non-specific low back pain. [Subjects and Methods] Thirty four patients with chronic non-specific low back pain were randomly assigned to McGill stabilization exercises group (n=17) and conventional physiotherapy group (n=17). In both groups, patients performed the corresponding exercises for six weeks. The visual analog scale (VAS), Quebec Low Back Pain Disability Scale Questionnaire and inclinometer were used to measure pain, functional disability, and active back flexion and extension range of motion, respectively. [Results] Statistically significant improvements were observed in pain, functional disability, and active back extension range of motion in McGill stabilization exercises group. However, active back flexion range of motion was the only clinical symptom that statistically increased in patients who performed conventional physiotherapy. There was no significant difference between the clinical characteristics while compared these two groups of patients. [Conclusion] The results of this study indicated that McGill stabilization exercises and conventional physiotherapy provided approximately similar improvement in pain, functional disability, and active back range of motion in patients with chronic non-specific low back pain. However, it appears that McGill stabilization exercises provide an additional benefit to patients with chronic non-specific low back, especially in pain and functional disability improvement.

Management options of chronic low back pain. A randomized blinded clinical trial.

PubMed

Nazzal, Mahmoud E; Saadah, Mohammed A; Saadah, Loai M; Al-Omari, Mahmoud A; Al-Oudat, Ziad A; Nazzal, Mohammed S; El-Beshari, Mahfoud Y; Al-Zaabi, Amani A; Alnuaimi, Yousif I

2013-04-01

To compare efficacies of 2 active programs in the management of chronic low back pain (CLBP). This prospective, stratified, randomized single-blinded controlled study was conducted in the Department of Rehabilitation Medicine, King Abdullah University Hospital, Irbid, Jordan, between February and December 2010. A total of 100 patients were randomized to either 6-weeks of multidisciplinary rehabilitation (group A) or therapist-assisted exercise (group B). At baseline and 6 weeks, the visual analogue scale (VAS) pain score was estimated, as a primary outcome measure. McGill pain score, Oswestry Disability Index (ODI), trunk forward flexion and extension, left and right lateral bending, were applied before and after treatment and were employed as secondary outcome measures. All outcome measures significantly improved in group A after treatment, compared with group B. The VAS, McGill, ODI scores, left and right lateral bending decreased significantly, whereas forward and backward bending increased. A significant number of patients returned to work in group A at the end of 6 weeks, compared with group B. These effects were maintained over 12 and 24 weeks of follow-up. Multidisciplinary rehabilitation improved functional indices and pain scale scores in group A compared with B. This would be an effective strategy in CLBP management.

STOVL Hot Gas Ingestion control technology

NASA Technical Reports Server (NTRS)

Amuedo, K. C.; Williams, B. R.; Flood, J. D.; Johns, A. L.

1991-01-01

A comprehensive wind tunnel test program was conducted to evaluate control of Hot Gas Ingestion (HGI) on a 9.2 percent scale model of the McDonnell Aircraft Company model 279-3C advanced Short Takeoff and Vertical Landing (STOVL) configuration. The test was conducted in the NASA-Lewis Research Center 9 ft by 15 ft Low Speed Wind Tunnel during the summer of 1987. Initial tests defined baseline HGI levels as determined by engine face temperature rise and temperature distortion. Subsequent testing was conducted to evaluate HGI control parametrically using Lift Improvement Devices (LIDs), forward nozzle splay angle, a combination of LIDs and forward nozzle splay angle, and main inlet blocking. The results from this test program demonstrate that HGI can be effectively controlled and that HGI is not a barrier to STOVL aircraft development.

Ada Compiler Validation Summary Report: Certificate Number: 901212I1. 11120 Tartan Inc., Tartan Ada VMS/960MC Version 4.0 VAXstation 3100 = Intel ICE960/25 on an VMS 5.2 Intel EXV80960MC Board

DTIC Science & Technology

1991-01-09

5.2 (Target), 90121211 .11120 6. AUTHOR( S ) IABG-AVFT IOttobrunn, Federal Republic of Germany 7 PERFORMING ORGANIZATION NAME( S ) AND ADDRESS(ES) N-1...FEDERAL REPUBLIC OF GERMANY 9 SPONSORINGMONITORING AGENCY NAME( S ) AND ADDRESS( ES) 10. SPONSORING/ONITORING AGENCY Ada Joint Program Office REPORT NUMBER...Ada implementacion for which validation status is realized. Host Computer A computer system where Ada source programs are transformec System into

Adequacy of physician documentation and correlation with assessment of transfusion appropriateness: a follow-up study in the setting of prospective audits and patient blood management.

PubMed

Madrigal, Emilio; Prajapati, Shyam; Avadhani, Vaidehi; Annen, Kyle; Friedman, Mark T

2017-02-01

A previous study in our hospitals correlated suboptimal documentation and failure to justify transfusions. In light of implemented blood-conservation strategies, including patient blood management (PBM) and prospective audits (PAs), we performed a follow-up study. We reviewed prospectively audited red blood cell (RBC) transfusions received by adult patients from January to July 2014. Survey forms were used to assess the level of documentation and to classify documentation as adequate, intermediate, or inadequate. Transfusions were deemed justified or not by comparisons with hospital transfusion guidelines. We also analyzed the effect of implemented blood-conservation strategies on our hospital transfusion rates and costs from 2009 to 2015. During the study period, there were 259 prospectively audited transfusion events (TEs) (one or more RBC units transfused to a patient), of which we reviewed 94 TEs (36.3%) in 87 patients. TEs with suboptimal (intermediate and inadequate) documentation accounted for 46.8% of the reviewed TEs, of which 81.8% could not be justified compared with 18.0% of nonjustified, adequately documented TEs. The correlation between suboptimal documentation and failure to justify transfusion was significant (p < 0.001). This correlation remained even in a comparison between the site with a PBM program and the sites without such a program. Overall transfusion rates declined after the introduction of PA, although the decline was only statistically significant at the sites with a PBM program. Suboptimal transfusion documentation remains problematic and is highly correlated with nonjustifiable transfusions. Newly adopted approaches to minimize blood transfusions have not improved transfusion documentation and corresponding out-of-guideline transfusions, although overall transfusions have been reduced by PA, particularly in the setting of a PBM program. © 2016 AABB.

NPOESS C3S Expandability: SafetyNetTM and McMurdo Improvements

NASA Astrophysics Data System (ADS)

Jamilkowski, M. L.; Paciaroni, J.; Pela, F.

2010-12-01

The National Oceanic & Atmospheric Administration (NOAA), Department of Defense (DoD), and National Aeronautics & Space Administration (NASA) are jointly acquiring the next-generation weather & environmental satellite system; the National Polar-orbiting Operational Environmental Satellite System (NPOESS). NPOESS replaces the current NOAA Polar-orbiting Operational Environmental Satellites (POES) and Dod's Defense Meteorological Satellite Program (DMSP). The NPOESS satellites carry a suite of sensors that collect meteorological, oceanographic, climatological, and solar-geophysical observations of the earth, atmosphere, and space. The command & telemetry portion of NPOESS is the Command, Control and Communications Segment (C3S), developed by Raytheon Intelligence & Information Systems. C3S is responsible for managing the overall NPOESS mission from control and status of the space and ground assets to ensuring delivery of timely, high quality data from the Space Segment (SS) to the Interface Data Processing Segment (IDPS) for processing. In addition, the C3S provides the globally distributed ground assets necessary to collect and transport mission, telemetry, and command data between the satellites and the processing locations. The C3S provides all functions required for day-to-day commanding & state-of-health monitoring of the NPP & NPOESS satellites, and delivery of Stored Mission Data (SMD) to each US Weather Central Interface Data Processor (IDP) for data products development and transfer to System subscribers. The C3S also monitors and reports system-wide health and status & data communications with external systems and between NPOESS segments. Two crucial elements of NPOESS C3S expandability are SafetyNetTM and communications improvements to McMurdo Station, Antarctica. SafetyNetTM is a key feature of NPOESS and a vital element of the C3S and Northrop Grumman Aerospace Systems patented data collection architecture. The centerpiece of SafetyNetTM is the system of fifteen globally-distributed ground receptors developed by Raytheon Company. These antennae will collect up to five times as much environmental data approximately four times faster than current polar-orbiting weather satellites. Once collected, these data will be forwarded near-instantaneously to US weather centrals via the global fiber optic network for processing in environmental prediction models. In January 2008, Raytheon Company achieved a significant milestone for the NPOESS program by successfully completing the first phase of a major communications upgrade for Antarctica. The upgrade of the off-continent satellite communications link at McMurdo Station more than tripled the bandwidth available for scientific research, weather prediction, and health & safety of those stationed at McMurdo. The project is part of the company’s C3S under development for NPOESS. This upgrade paves the way for a second major communications upgrade planned for 2012 in preparation for the use of McMurdo Station as one of the 15 NPOESS ground stations worldwide that will be receiving environmental data collected by the NPOESS satellites. SafetyNet is a trademark of Northrop Grumman Aerospace Systems.

McDonald Observatory Visitor Center Education Programs

NASA Astrophysics Data System (ADS)

Hemenway, M. K.; Armosky, B. J.; Wetzel, M.; Preston, S.

2002-12-01

The opening of the new Visitor Center at McDonald Observatory in Fort Davis, Texas provided an opportunity to greatly expand the Observatory's outreach efforts to students and teachers. In addition to a theater, outdoor telescope park, and amphitheater, the facility contains a classroom and an exhibit entitled ``Decoding Starlight." In preparation for the opening, new teacher-friendly materials were written to provide standards aligned (both state and national) classroom activities for students. These activities form the core for both the multi-day Professional Development Program for teachers and the Student Field Experience Program. Student Field Experiences often begin with a tour specifically designed for student groups to emphasize careers and life at the Observatory. The group then interacts with the exhibit using Exhibit Guides that were developed for various grade levels. When their schedule allows, student groups may also participate in nighttime observing activities. Smaller groups (under 30 members) may choose from a menu of hands-on activities offered within the classroom. The positive reception of these activities has led to their inclusion in the existing Elderhostel program for senior citizens. We gratefully acknowledge the support of NSF 96-26965 ``Fingerprinting the Universe - An Interactive, Bilingual Exhibit on Spectroscopy," NSF 97-05340 ``Universo, Hispanic Heritage Month Programs, and StarDate in the Classroom," and NASA IDEAS HST-ED-90234-.01 ``Enriching the Experience at McDonald Observatory: Pre/Post Visit Materials for Teachers and Students."

Video laryngoscopy in pre-hospital critical care - a quality improvement study.

PubMed

Rhode, Marianne Grønnebæk; Vandborg, Mads Partridge; Bladt, Vibeke; Rognås, Leif

2016-06-13

Pre-hospital endotracheal intubation is challenging and repeated endotracheal intubation is associated with increased morbidity and mortality. We investigated whether the introduction of the McGrath MAC video laryngoscope as the primary device for pre-hospital endotracheal intubation could improve first-pass success rate in our anaesthesiologist-staffed pre-hospital critical care services. We also investigated the incidence of failed pre-hospital endotracheal intubation, the use of airway adjuncts and back-up devices and problems encountered using the McGrath MAC video laryngoscope. Prospective quality improvement study collecting data from all adult pre-hospital endotracheal intubation performed by four anaesthesiologist-staffed pre-hospital critical care teams between December 15(th) 2013 and December 15(th) 2014. We registered data from 273 consecutive patients. When using the McGrath MAC video laryngoscope the overall pre-hospital endotracheal intubation first-pass success rate was 80.8 %. Following rapid sequence intubation (RSI) it was 88.9 %. This was not significantly different from previously reported first-pass success rates in our system (p = 0.27 and p = 0.41). During the last nine months of the study period the overall first-pass success rate was 80.1 (p = 0.47) but the post-RSI first-pass success rate improved to 94.4 % (0.048). The overall pre-hospital endotracheal intubation success rate with the McGrath MAC video laryngoscope was 98.9 % (p = 0.17). Gastric content, blood or secretion in the airway resulted in reduced vision when using the McGrath MAC video laryngoscope. In this study of video laryngoscope implementation in a Scandinavian anaesthesiologist-staffed pre-hospital critical care service, overall pre-hospital endotracheal first pass success rate did not change. The post-RSI first-pass success rate was significantly higher during the last nine months of our 12-month study compared with our results from before introducing McGrath MAC video laryngoscope. The implementation of the Standard Operating Procedure and check list for pre-hospital anaesthesia during the study period may have influenced the first-pass success rate and constitutes a potential confounder. The potential limitations of the McGrath MAC video laryngoscope when there are gastric content, blood and secretions in the airways need to be further investigated before the McGrath MAC video laryngoscope can be recommended as the primary device in all pre-hospital endotracheal intubations.

Metal Nanoparticles/Porous Silicon Microcavity Enhanced Surface Plasmon Resonance Fluorescence for the Detection of DNA.

PubMed

Wang, Jiajia; Jia, Zhenhong

2018-02-23

A porous silicon microcavity (PSiMC) with resonant peak wavelength of 635 nm was fabricated by electrochemical etching. Metal nanoparticles (NPs)/PSiMC enhanced fluorescence substrates were prepared by the electrostatic adherence of Au NPs that were distributed in PSiMC. The Au NPs/PSiMC device was used to characterize the target DNA immobilization and hybridization with its complementary DNA sequences marked with Rhodamine red (RRA). Fluorescence enhancement was observed on the Au NPs/PSiMC device substrate; and the minimum detection concentration of DNA ran up to 10 pM. The surface plasmon resonance (SPR) of the MC substrate; which is so well-positioned to improve fluorescence enhancement rather the fluorescence enhancement of the high reflection band of the Bragg reflector; would welcome such a highly sensitive in biosensor.

Ecological effects of contaminants in McCoy Branch, 1989-1990

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ryon, M.G.

1992-01-01

The 1984 Hazardous and Solid Waste Amendments to the Resource Conservation and Recovery Act (RCRA) required assessment of all current and former solid waste management units. Such a RCRA Facility Investigation (RFI) was required of the Y-12 Plant for their Filled Coal Ash Pond on McCoy Branch. Because the disposal of coal ash in the ash pond, McCoy Branch, and Rogers Quarry was not consistent with the Tennessee Water Quality Act, several remediation steps were implemented or planned for McCoy Branch to address disposal problems. The McCoy Branch RFI plan included provisions for biological monitoring of the McCoy Branch watershed.more » The objectives of the biological monitoring were to: (1) document changes in biological quality of McCoy Branch after completion of a pipeline and after termination of all discharges to Rogers Quarry, (2) provide guidance on the need for additional remediation, and (3) evaluate the effectiveness of implemented remedial actions. The data from the biological monitoring program will also determine if the classified uses, as identified by the State of Tennessee, of McCoy Branch are being protected and maintained. This report discusses results from toxicity monitoring of snails fish community assessment, and a Benthic macroinvertebrate community assessment.« less

Comparison of Lecture-Based Learning vs Discussion-Based Learning in Undergraduate Medical Students.

PubMed

Zhao, Beiqun; Potter, Donald D

2016-01-01

To compare lecture-based learning (LBL) and discussion-based learning (DBL) by assessing immediate and long-term knowledge retention and application of practical knowledge in third- and fourth-year medical students. A prospective, randomized control trial was designed to study the effects of DBL. Medical students were randomly assigned to intervention (DBL) or control (LBL) groups. Both the groups were instructed regarding the management of gastroschisis. The control group received a PowerPoint presentation, whereas the intervention group was guided only by an objectives list and a gastroschisis model. Students were evaluated using a multiple-choice pretest (Pre-Test MC) immediately before the teaching session, a posttest (Post-Test MC) following the session, and a follow-up test (Follow-Up MC) at 3 months. A practical examination (PE), which tested simple skills and management decisions, was administered at the end of the clerkship (Initial PE) and at 3 months after clerkship (Follow-Up PE). Students were also given a self-evaluation immediately following the Post-Test MC to gauge satisfaction and comfort level in the management of gastroschisis. University of Iowa Hospitals and Clinics and the Carver College of Medicine, Iowa City, IA. A total of 49 third- and fourth-year medical students who were enrolled in the general surgery clerkship were eligible for this study. Enrollment into the study was completely voluntary. Of the 49 eligible students, 36 students agreed to participate in the study, and 27 completed the study. Mean scores for the Pre-Test MC, Post-Test MC, and Follow-Up MC were similar between the control and intervention groups. In the control group, the Post-Test MC scores were significantly greater than Pre-Test MC scores (8.92 ± 0.79 vs 4.00 ± 1.04, p < 0.0001), whereas the Follow-Up MC scores were significantly lower than Post-Test MC scores (7.17 ± 1.75 vs 8.92 ± 0.79, p = 0.005). In the control group, the Follow-Up MC scores were significantly greater than Pre-Test MC scores (7.17 ± 1.75 vs 4.00 ± 1.04, p < 0.0001). Analysis of variance for all control group MC examinations had a p < 0.0001. In the intervention group, the Post-Test MC scores were significantly greater than Pre-Test MC scores (8.33 ± 1.23 vs 4.60 ± 1.55, p < 0.0001), whereas the Follow-Up MC scores were significantly lower than Post-Test MC scores (7.13 ± 1.77 vs 8.33 ± 1.23, p = 0.04). In the intervention group, the Follow-Up MC scores were significantly greater than Pre-Test MC scores (7.13 ± 1.77 vs 4.60 ± 1.55, p = 0.0002). Analysis of variance for all intervention group MC examinations had a p < 0.0001. Mean scores for the Initial PE were significantly higher for the intervention group compared with the control group's score (7.47 ± 1.68 vs 5.25 ± 2.34, p = 0.008). Mean scores for the Follow-Up PE were significantly higher for the intervention group compared with the control group's score (7.87 ± 1.77 vs 5.83 ± 2.04, p = 0.005). A comparison of Initial PE vs Follow-Up PE was not significant in either group. Students in the intervention group were more comfortable in the immediate management of gastroschisis and placement of a silo and felt that the educational experience was more worthwhile than students in the control group did. After a single instructional session, there was a significant difference in the students' scores between the control and the intervention groups on both administrations of the PEs. There were no significant differences between the 2 groups in any administration of the MC examinations. This seems to suggest that DBL may lead to better practical knowledge and potentially improved long-term knowledge retention when compared with LBL. Students in the DBL group also felt more comfortable with the management of gastroschisis and were more satisfied with the educational session. Copyright © 2015 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hecker, Siegfried; Gottemoeller, Rose; Reis, Victor H.

A short oral history of the NNSA's Stockpile Stewardship Program, produced in association with the 20th anniversary of the program. It features Siegfried Hecker, Rose Gottemoeller, Victor Reis, Charles McMillan, Joan Rohlfing, Omar Hurricane, Roger Hagengruber, and John Taylor.

34 CFR 237.1 - What is the Christa McAuliffe Fellowship Program?

Code of Federal Regulations, 2010 CFR

2010-07-01

... to reward excellence in teaching by encouraging outstanding teachers to continue their education, to develop innovative programs, to consult with or assist LEAs, private schools, or private school systems...

Conformer-specific microwave spectroscopy of 3-phenylpropionitrile by strong field coherence breaking

NASA Astrophysics Data System (ADS)

Fritz, Sean M.; Hernandez-Castillo, A. O.; Abeysekera, Chamara; Hays, Brian M.; Zwier, Timothy S.

2018-07-01

Strong field coherence breaking (SFCB) was used with a chirped-pulse Fourier Transform microwave spectrometer to obtain conformer-specific rotational spectra of 3-phenylpropionitrile in the 8-18 GHz region. Transitions belonging to anti and gauche conformers were identified and assigned and accurate experimental rotational constants were determined to provide insight to the molecular structure. Experimental rotational transitions provided relative abundances in the supersonic expansion. A modified line picking scheme was developed in the process to modulate more transitions and improve the overall efficiency of the SFCB multiple selective excitation technique.

Improvement of McKibben Artificial Muscle with Long Stroke Motion and Its Application

NASA Astrophysics Data System (ADS)

Akagi, Tetsuya; Dohta, Shujiro; Kuno, Hiroaki; Ihara, Michinori

The actuators required for a wearable system need to be flexible so as not to injure the body. The purpose of this study is to develop a flexible and lightweight actuator which can be safe enough to be attached to the human body. In the previous study, a new type of McKibben artificial muscle that had a long stroke of more than 80 % of its original length was proposed and tested. However, the damages on the tube of the actuator were found. They are caused by a large friction between the slide stage and the tube. Therefore, the life time of the actuator becomes shorter. In this paper, the improved McKibben actuator which consists of a McKibben artificial muscle on the market (FESTO Co. Ltd.), steel balls as a cylinder head and two pairs of slide stages is proposed and tested. The slide stage has steel balls set on the inner bore of the stage to decrease the friction. The steel ball in the McKibben actuator is held by two pairs of slide stages from both sides of the ball. As a result, the minimum driving pressure of the improved actuator decreases about 68 % compared with that of the previous one. The actuator can realize both pushing and pulling motion even if it has flexibility. By using these properties of the actuator, the various rehabilitation devices were proposed and tested.

The Value of Applied Research: Retrieval Practice Improves Classroom Learning and Recommendations from a Teacher, a Principal, and a Scientist

ERIC Educational Resources Information Center

Agarwal, Pooja K.; Bain, Patrice M.; Chamberlain, Roger W.

2012-01-01

Over the course of a 5-year applied research project with more than 1,400 middle school students, evidence from a number of studies revealed that retrieval practice in authentic classroom settings improves long-term learning (Agarwal et al. 2009; McDaniel et al., "Journal of Educational Psychology" 103:399-414, 2011; McDaniel et al.…

77 FR 30592 - Agency Information Collection (Yellow Ribbon Agreement Under Title 38 U.S.C. Chapter 33) Activity...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-23

... McLamb, Program Analyst, Enterprise Records Service. [FR Doc. 2012-12384 Filed 5-22-12; 8:45 am] BILLING... Office of Management and Budget (OMB) for review and comment. The PRA submission describes the nature of... the Submission Contact: Denise McLamb, Enterprise Records Service (005R1B), Department of Veterans...

Modeling the Problem-Based Learning Preferences of McMaster University Undergraduate Medical Students Using a Discrete Choice Conjoint Experiment

ERIC Educational Resources Information Center

Cunningham, Charles E.; Deal, Ken; Neville, Alan; Rimas, Heather; Lohfeld, Lynne

2006-01-01

Objectives: To use methods from the field of marketing research to involve students in the redesign of McMaster University's small group, problem-based undergraduate medical education program. Methods: We used themes from a focus group conducted in an electronic decision support lab to compose 14 four-level educational attributes. Undergraduate…

Service with Style: Micki McIntyre--Health Sciences Library, University of Medicine and Dentistry of New Jersey

ERIC Educational Resources Information Center

Library Journal, 2005

2005-01-01

After a brief career in musical theater, Micki McIntyre entered the graduate library program at Columbia University, where she noticed a poster advertising free tuition to library employees. "There was a vacancy at the health sciences library, and that's how a theater major became a medical librarian." She's a medical librarian with…

House Hearing Nunn-McCurdy Review of NPOESS

NASA Image and Video Library

2006-06-08

Under Secretary of the Air Force Dr. Ronald Sega, testifies before the House Committee on Science and Technology regarding the future of the National Polar-orbiting Operational Environmental Satellite System (NPOESS) and results of the Nunn-McCurdy review of NOAA’s weather satellite program, Thursday, June 8, 2006, at the Rayburn House Office Building in Washington. Photo Credit: (NASA/Bill Ingalls)

House Hearing Nunn-McCurdy Review of NPOESS

NASA Image and Video Library

2006-06-07

Under Secretary of the Air Force Dr. Ronald Sega, testifies before the House Committee on Science and Technology regarding the future of the National Polar-orbiting Operational Environmental Satellite System (NPOESS) and results of the Nunn-McCurdy review of NOAA’s weather satellite program, Thursday, June 8, 2006, at the Rayburn House Office Building in Washington. Photo Credit: (NASA/Bill Ingalls)

An Examination of How Women and Underrepresented Racial/Ethnic Minorities Experience Barriers in Biomedical Research and Medical Programs

ERIC Educational Resources Information Center

Chakraverty, Devasmita

2013-01-01

Women in medicine and biomedical research often face challenges to their retention, promotion, and advancement to leadership positions (McPhillips et al., 2007); they take longer to advance their careers, tend to serve at less research-intensive institutions and have shorter tenures compared to their male colleagues (White, McDade, Yamagata, &…

Installation Restoration Program. Preliminary Assessment: 118th Tactical Airlift Wing Tennessee Air National Guard, Nashville International Airport, Nashville, Tennessee

DTIC Science & Technology

1988-12-01

disseminated silt and shale partings. The unit is medium-bedded and is characterized by numerous fossils of the brachiopod Resseralla fertilis . The... runoff from the Base is collected by the storm sewer system and discharged to McCrory Creek (Figure 6). The confluence of McCrory Creek and the Stone

McDaniel Step Ahead: A Summer Transitional Program for First Year College Students with Disabilities

ERIC Educational Resources Information Center

Lawson, Dana L.; Gould, Sarah A.; Conley, Melanie L.

2016-01-01

In recent years, there has been a significant increase in the number of students with disabilities seeking postsecondary education. The complexity of needs is also increasing, resulting in more students withdrawing from college or taking leaves of absence in their first year. In 2012, the Student Academic Support Services office (SASS) at McDaniel…

Astronaut McDivitt - Blood Pressure Check - Preflight Examination - Merritt Island, FL

NASA Image and Video Library

1965-06-01

S65-19524 (1 June 1965) --- Dr. Charles A. Berry, chief of Center Medical Programs, MSC, Houston, Texas, prepares to check the blood pressure of astronaut James A. McDivitt, command pilot for the Gemini-Titan 4 spaceflight. McDivitt is on the tilt table at the Aero Medical Area, MSC, Merritt Island, where he and astronaut Edward H. White II (out of frame), GT-4 pilot, underwent preflight physicals in preparation for the four-day, 62-revolution spaceflight. The two astronauts were declared in top physical condition. In the background is Dr. Gordon Benson, NASA physician at Cape Kennedy.

The 8-18 GHz radar spectrometer

NASA Technical Reports Server (NTRS)

Bush, T. F.; Ulaby, F. T.

1973-01-01

The design, construction, testing, and accuracy of an 8-18 GHz radar spectrometer, an FM-CW system which employs a dual antenna system, is described. The antennas, transmitter, and a portion of the receiver are mounted at the top of a 26 meter hydraulic boom which is in turn mounted on a truck for system mobility. HH and VV polarized measurements are possible at incidence angles ranging from 0 deg. to 80 deg. Calibration is accomplished by referencing the measurements against a Luneberg lens of known radar cross section.

Bar Code Applications at the Naval Publications and Forms Center.

DTIC Science & Technology

1986-07-01

Note 4 811 758 NAVAIR 0 0 See Note 4 813 469 NAVAIR 0 0 See Note 4 816 10062 NAVAIR 0 0 See Note 4 818 8366 NAVAIR 0 0 See Note 4 819 1392 NAVAiR 0 0...816 10062 NAVAIR 0 0 See Note 4 818 8366 NAVAIR 0 0 See Note 4 819 1392 NAVAIR 0 0 See Nole 4 850 255 NAVAIR 0 0 See Note 4 851 272 NAVAIR 0 0 See Note

Thomas C. McMurtry

NASA Technical Reports Server (NTRS)

1982-01-01

Thomas C. McMurtry in November 1982. He graduated in June 1957 from the University of Notre Dame with a Bachelor of Science degree in Mechanical Engineering. McMurtry had been part of the university's Navy ROTC program, and after graduation he joined the Navy as a pilot. Before retiring from the Navy in 1964 as a Lieutenant, he graduated from the U.S. Navy Test Pilot School, and had flown such aircraft as the F9F, A3D, A4D, F3D, F-8, A-6, and S-2. McMurtry was then a consultant for the Lockheed Corporation until joining NASA as a research pilot in 1967. While at the Dryden Flight Research Center, he was co-project pilot on the F-8 Digital Fly-By-Wire program, and the 747 Shuttle Carrier Aircraft, as well as project pilot on the F-15 Digital Electronic Engine Control (DEEC) project, the KC-135 Winglets, the F-8 Supercritical Wing project, and the AD-1 Oblique Wing Project. He also made research flights in NASA's YF-12C aircraft (actually a modified SR-71). McMurtry made the last glide flight of the X-24B lifting body on November 26, 1975, and was co-pilot of the 747 Shuttle Carrier Aircraft on the first free flight of the space shuttle Enterprise on August 12, 1977. He was involved in several remotely piloted research vehicle programs, including the FAA/NASA 720 Controlled Impact Demonstration and the 3/8 F-15 Spin Research Vehicle. During McMurtry's 32 years as a pilot and manager at Dryden, he received numerous awards. These include the NASA Exceptional Service Award for his work on the F-8 Supercritical Wing, and the Iven C. Kincheloe Award from the Society of Experimental Test Pilots for his role as chief pilot on the AD-1 project, the NASA Distinguished Service Medal, and the 1999 Milton O. Thomson Lifetime Achievement Award. McMurtry also held a number of management positions at Dryden, including Chief Pilot, Director of Flight Operations, Associate Director of Flight Operations, and was the acting Chief Engineer at the time of his retirement on June 3, 1999. Since becoming a pilot in 1958, he logged more than 11,000 hours of flight time, in aircraft ranging from a WACO open cockpit biplane to a Mach 3 YF-12C, as well as navy trainers, fighters and attack airplanes, the U-2, F-104 and FA-18 chase planes, and diverse research aircraft. McMurtry's fondest memories are of early morning take-offs from Edwards AFB.

Melanocortin-4-receptors Expressed by Cholinergic Neurons Regulate Energy Balance and Glucose Homeostasis

PubMed Central

Rossi, Jari; Balthasar, Nina; Olson, David; Scott, Michael; Berglund, Eric; Lee, Charlotte E.; Choi, Michelle J.; Lauzon, Danielle; Lowell, Bradford B.; Elmquist, Joel K.

2011-01-01

Summary Melanocortin-4-receptor (MC4R) mutations cause dysregulation of energy balance and hyperinsulinemia. We have used mouse models to study the physiological roles of extrahypothalamic MC4Rs. Re-expression of MC4Rs in cholinergic neurons (ChAT-Cre, loxTB MC4R mice) modestly reduced body weight gain without altering food intake and was sufficient to normalize energy expenditure and attenuate hyperglycemia and hyperinsulinemia. In contrast, restoration of MC4R expression in brainstem neurons including those in the dorsal motor nucleus of the vagus (Phox2b-Cre, loxTB MC4R mice) was sufficient to attenuate hyperinsulinemia, while the hyperglycemia and energy balance were not normalized. Additionally, hepatic insulin action and insulin mediated-suppression of hepatic glucose production were improved in ChAT-Cre, loxTB MC4R mice. These findings suggest that MC4Rs expressed by cholinergic neurons regulate energy expenditure and hepatic glucose production. Our results also provide further evidence of the dissociation in pathways mediating the effects of melanocortins on energy balance and glucose homeostasis. PMID:21284986

Effect of Thermal Exposure on the Tensile Properties of Aluminum Alloys for Elevated Temperature Service

NASA Technical Reports Server (NTRS)

Edahl, Robert A., Jr.; Domack, Marcia

2004-01-01

Tensile properties were evaluated for four aluminum alloys that are candidates for airframe applications on high speed transport aircraft. These alloys included the Al-Cu-Mg-Ag alloys C415 and C416 and the Al-Cu-Li-Mg-Ag alloys RX818 and ML377. The Al-Cu-Mg alloys CM001, which was used on the Concorde SST, and 1143, which was modified from the alloy used on the TU144 Russian supersonic aircraft, were tested for comparison. The alloys were subjected to thermal exposure at 200 F, 225 F and 275 F for times up to 30,000 hours. Tensile tests were performed on thermally-exposed and as-received material at -65 F, room temperature, 200 F, 225 F and 275 F. All four candidate alloys showed significant tensile property improvements over CM001 and 1143. Room temperature yield strengths of the candidate alloys were at least 20% greater than for CM001 and 1143, for both the as-received and thermally-exposed conditions. The strength levels of alloy RX818 were the highest of all materials investigated, and were 5-10% higher than for ML377, C415 and C416 for the as-received condition and after 5,000 hours thermal exposure. RX818 was removed from this study after 5,000 hours exposure due to poor fracture toughness performance observed in a parallel study. After 30,000 hours exposure at 200 F and 225 F, the alloys C415, C416 and ML377 showed minor decreases in yield strength, tensile strength and elongation when compared to the as-received properties. Reductions in tensile strength from the as-received values were up to 25% for alloys C415, C416 and ML377 after 15,000 hours exposure at 275 F.

75 FR 51047 - Notice of Receipt of a Pesticide Petition Filed for Residues of Complex Polymeric Polyhydroxy...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-18

... Adams, Biopesticides and Pollution Prevention Division (7511P), Office of Pesticide Programs... McDavit, Acting Director, Biopesticides and Pollution Prevention Division, Office of Pesticide Programs...

Junior High Students Produce Daily TV Today Program

ERIC Educational Resources Information Center

Worzala, Louise Hicks

1976-01-01

Describes the seven-minute, closed-circuit television program for 500 students and teachers which is entirely planned and produced by an eighth grade broadcast journalism class at a McHenry (Illinois) junior high school. (JM)

TH-E-BRE-09: TrueBeam Monte Carlo Absolute Dose Calculations Using Monitor Chamber Backscatter Simulations and Linac-Logged Target Current

DOE Office of Scientific and Technical Information (OSTI.GOV)

A, Popescu I; Lobo, J; Sawkey, D

2014-06-15

Purpose: To simulate and measure radiation backscattered into the monitor chamber of a TrueBeam linac; establish a rigorous framework for absolute dose calculations for TrueBeam Monte Carlo (MC) simulations through a novel approach, taking into account the backscattered radiation and the actual machine output during beam delivery; improve agreement between measured and simulated relative output factors. Methods: The ‘monitor backscatter factor’ is an essential ingredient of a well-established MC absolute dose formalism (the MC equivalent of the TG-51 protocol). This quantity was determined for the 6 MV, 6X FFF, and 10X FFF beams by two independent Methods: (1) MC simulationsmore » in the monitor chamber of the TrueBeam linac; (2) linac-generated beam record data for target current, logged for each beam delivery. Upper head MC simulations used a freelyavailable manufacturer-provided interface to a cloud-based platform, allowing use of the same head model as that used to generate the publicly-available TrueBeam phase spaces, without revealing the upper head design. The MC absolute dose formalism was expanded to allow direct use of target current data. Results: The relation between backscatter, number of electrons incident on the target for one monitor unit, and MC absolute dose was analyzed for open fields, as well as a jaw-tracking VMAT plan. The agreement between the two methods was better than 0.15%. It was demonstrated that the agreement between measured and simulated relative output factors improves across all field sizes when backscatter is taken into account. Conclusion: For the first time, simulated monitor chamber dose and measured target current for an actual TrueBeam linac were incorporated in the MC absolute dose formalism. In conjunction with the use of MC inputs generated from post-delivery trajectory-log files, the present method allows accurate MC dose calculations, without resorting to any of the simplifying assumptions previously made in the TrueBeam MC literature. This work has been partially funded by Varian Medical Systems.« less

The NASA Human Research Wiki - An Online Collaboration Tool

NASA Technical Reports Server (NTRS)

Barr, Yael; Rasbury, Jack; Johnson, Jordan; Barstend, Kristina; Saile, Lynn; Watkins, Sharmi

2012-01-01

The Exploration Medical Capability (ExMC) element is one of six elements of the Human Research Program (HRP). ExMC is charged with decreasing the risk of: "Inability to adequately recognize or treat an ill or injured crew member" for exploration-class missions In preparation for exploration-class missions, ExMC has compiled a large evidence base, previously available only to persons within the NASA community. ExMC has developed the "NASA Human Research Wiki" in an effort to make the ExMC information available to the general public and increase collaboration within and outside of NASA. The ExMC evidence base is comprised of several types of data, including: (1)Information on more than 80 medical conditions which could occur during space flight (a)Derived from several sources (b)Including data on incidence and potential outcomes, as captured in the Integrated Medical Model s (IMM) Clinical Finding Forms (CliFFs). (2)Approximately 25 gap reports (a)Identify any "gaps" in knowledge and/or technology that would need to be addressed in order to provide adequate medical support for these novel missions.

Persistence of organochlorine chemical residues in fish from the Tombigbee River (Alabama, USA): Continuing risk to wildlife from a former DDT manufacturing facility

USGS Publications Warehouse

Hinck, J.E.; Norstrom, R.J.; Orazio, C.E.; Schmitt, C.J.; Tillitt, D.E.

2009-01-01

Organochlorine pesticide and total polychlorinated biphenyl (PCB) concentrations were measured in largemouth bass from the Tombigbee River near a former DDT manufacturing facility at McIntosh, Alabama. Evaluation of mean p,p???- and o,p???-DDT isomer concentrations and o,p???- versus p,p???-isomer proportions in McIntosh bass indicated that DDT is moving off site from the facility and into the Tombigbee River. Concentrations of p,p???-DDT isomers in McIntosh bass remained unchanged from 1974 to 2004 and were four times greater than contemporary concentrations from a national program. Total DDT in McIntosh bass exceeded dietary effect concentrations developed for bald eagle and osprey. Hexachlorobenzene, PCBs, and toxaphene concentrations in bass from McIntosh also exceeded thresholds to protect fish and piscivorous wildlife. Whereas concentrations of DDT and most other organochlorine chemicals in fish have generally declined in the U.S. since their ban, concentrations of DDT in fish from McIntosh remain elevated and represent a threat to wildlife.

Psychometric characteristics of single-word tests of children's speech sound production.

PubMed

Flipsen, Peter; Ogiela, Diane A

2015-04-01

Our understanding of test construction has improved since the now-classic review by McCauley and Swisher (1984). The current review article examines the psychometric characteristics of current single-word tests of speech sound production in an attempt to determine whether our tests have improved since then. It also provides a resource that clinicians may use to help them make test selection decisions for their particular client populations. Ten tests published since 1990 were reviewed to determine whether they met the 10 criteria set out by McCauley and Swisher (1984), as well as 7 additional criteria. All of the tests reviewed met at least 3 of McCauley and Swisher's (1984) original criteria, and 9 of 10 tests met at least 5 of them. Most of the tests met some of the additional criteria as well. The state of the art for single-word tests of speech sound production in children appears to have improved in the last 30 years. There remains, however, room for improvement.

NASA Remembers Astronaut Bruce McCandless II

NASA Image and Video Library

2017-12-22

Former NASA Astronaut Bruce McCandless II, best known for his iconic free-floating spacewalk on a 1984 shuttle flight, died on Dec. 21 at the age of 80. A native of Boston, McCandless II attended the U.S. Naval Academy and served as a naval aviator before joining NASA in 1966. He served in support or backup roles during the Apollo and Skylab programs, including serving as the communicator from mission control to the Apollo 11 crew during their historic 1969 moonwalk. On Feb. 7, 1984, during the Space Shuttle Challenger’s STS-41B mission, he made the first, untethered, free flight spacewalk in the Manned Maneuvering Unit. In 1990, McCandless II was part of the crew on Space Shuttle Discovery’s STS-31 mission, which deployed the Hubble Space Telescope.

Personal Background Interview of Jim McBarron

NASA Technical Reports Server (NTRS)

McBarron, Jim; Wright, Rebecca

2012-01-01

Jim McBarron exhibits a wealth of knowledge gathered from more than 40 years of experience with NASA, EVA, and spacesuits. His biography, progression of work at NASA, impact on EVA and the U.S. spacesuit, and career accomplishments are of interest to many. Wright, from the JSC History Office, conducted a personal background interview with McBarron. This interview highlighted the influences and decision-making methods that impacted McBarron's technical and management contributions to the space program. Attendees gained insight on the external and internal NASA influences on career progression within the EVA and spacesuit, and the type of accomplishments and technical advances that committed individuals can make. He concluded the presentation with a question and answer period that included a brief discussion about close calls and Russian spacesuits.

Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and prevent multiple organ damage

PubMed Central

Giuliani, D; Mioni, C; Bazzani, C; Zaffe, D; Botticelli, A R; Capolongo, S; Sabba, A; Galantucci, M; Iannone, A; Grieco, P; Novellino, E; Colombo, G; Tomasi, A; Catania, A; Guarini, S

2007-01-01

Background and purpose: In circulatory shock, melanocortins have life-saving effects likely to be mediated by MC4 receptors. To gain direct insight into the role of melanocortin MC4 receptors in haemorrhagic shock, we investigated the effects of two novel selective MC4 receptor agonists. Experimental approach: Severe haemorrhagic shock was produced in rats under general anaesthesia. Rats were then treated with either the non-selective agonist [Nle4, D-Phe7]α-melanocyte-stimulating hormone (NDP-α-MSH) or with the selective MC4 agonists RO27-3225 and PG-931. Cardiovascular and respiratory functions were continuously monitored for 2 h; survival rate was recorded up to 24 h. Free radicals in blood were measured using electron spin resonance spectrometry; tissue damage was evaluated histologically 25 min or 24 h after treatment. Key results: All shocked rats treated with saline died within 30-35 min. Treatment with NDP-α-MSH, RO27-3225 and PG-931 produced a dose-dependent (13-108 nmol kg-1 i.v.) restoration of cardiovascular and respiratory functions, and improved survival. The three melanocortin agonists also markedly reduced circulating free radicals relative to saline-treated shocked rats. All these effects were prevented by i.p. pretreatment with the selective MC4 receptor antagonist HS024. Moreover, treatment with RO27-3225 prevented morphological and immunocytochemical changes in heart, lung, liver, and kidney, at both early (25 min) and late (24 h) intervals. Conclusions and Implications: Stimulation of MC4 receptors reversed haemorrhagic shock, reduced multiple organ damage and improved survival. Our findings suggest that selective MC4 receptor agonists could have a protective role against multiple organ failure following circulatory shock. PMID:17245369

Catalog based two-color, relative photometry of NEOs at McDonald Observatory

NASA Astrophysics Data System (ADS)

Barker, E. S.; Györgyey Ries, J.; Shelus, P. J.; Ricklefs, R. L.

2001-11-01

The McDonald Observatory astrometry group has been involved in Solar System positional observations since the early 1970's. Since 1995, it has evolved to a CCD-based, almost totally automated, astrometry package. We are focusing our observational program on Near Earth Objects (NEOs) as part of NASA's mission to discover and catalogue 90 percent of NEOs with diameters larger than 1 km by 2008. We carry out confirmation observations of newly discovered objects and contribute to orbit improvements of under-observed objects. Understanding the overall hazard that these objects pose to Earth requires their dynamical and physical characterization. We recently adopted the USNO-A2.0 catalogue to improve our astrometric results. The catalog, however, also provides stellar magnitudes in the standard Johnson R and B photometric bands. After completing the night’s observing program, we now regularly provide the IAU with R magnitudes in addition to astrometric positions. Our limiting magnitude in R is near 22 in a 15 minute exposure over a 46 arcmin field on the 0.8m prime focus camera. Typically, we are scheduled for 4 nights each lunation, but our semi-automated, IRAF/ICE based program can be used by other 0.8m users. We are testing procedures that will include B and V exposures as part of our standard confirmation triplet. We have confirmed that switching filters between exposures on standard fields does not compromise the astrometric accurary. Thus, we should be able to provide two color, sequential, relative photometry of any newly discovered asteroid, as part of the confirmation process. The time interval between exposures is less than 20 minutes, short compared to most asteroid rotation times. Consequently, a meaningful color index can be obtained in parallel with the astrometric positions. Although B-R is not the usual color index used in asteroid classification studies, we are testing whether we can use it as a quick diagnostic tool to roughly classify newly discovered NEOs as by product of our astrometric observing sequence. Preliminary results will be presented at the meeting. This research is funded by NASA's NEO Observation Program grants NAG5-6863 and NAG5-10183.

Application of Enhanced Sampling Monte Carlo Methods for High-Resolution Protein-Protein Docking in Rosetta

PubMed Central

Zhang, Zhe; Schindler, Christina E. M.; Lange, Oliver F.; Zacharias, Martin

2015-01-01

The high-resolution refinement of docked protein-protein complexes can provide valuable structural and mechanistic insight into protein complex formation complementing experiment. Monte Carlo (MC) based approaches are frequently applied to sample putative interaction geometries of proteins including also possible conformational changes of the binding partners. In order to explore efficiency improvements of the MC sampling, several enhanced sampling techniques, including temperature or Hamiltonian replica exchange and well-tempered ensemble approaches, have been combined with the MC method and were evaluated on 20 protein complexes using unbound partner structures. The well-tempered ensemble method combined with a 2-dimensional temperature and Hamiltonian replica exchange scheme (WTE-H-REMC) was identified as the most efficient search strategy. Comparison with prolonged MC searches indicates that the WTE-H-REMC approach requires approximately 5 times fewer MC steps to identify near native docking geometries compared to conventional MC searches. PMID:26053419

Effect of Cricoid Pressure on Laryngeal View During Macintosh, McGrath MAC X-Blade and GlideScope Video Laryngoscopies

PubMed Central

Arslan, Zehra İpek; Solak, Mine

2017-01-01

Objective Cricoid pressure is useful in fasted patients requiring emergency intubation. We compared the effect of cricoid pressure on laryngeal view during Macintosh, McGrath MAC X-Blade and GlideScope video laryngoscopy. Methods After obtaining approval from the Human Research Ethics Committee and written informed consent from patients, we enrolled 120 patients (American Society of Anesthesiologists I–II, age 18–65 years) undergoing elective surgery that required endotracheal intubation in this prospective randomised study. Patients were divided into three groups (Macintosh, McGrath MAC X-Blade and GlideScope). Results Demographic and airway variables were similar in the groups. Cormack-Lehane grades were improved or unchanged on using cricoid pressure in Macintosh and McGrath MAC X-Blade groups. However, laryngeal views worsened in 12 patients (30%), remained unchanged in 26 patients (65%) and improved in 2 patients (5%) in the GlideScope group (p<0.001). Insertion and intubation times for Macintosh and McGrath MAC X-Blade video laryngoscopes were similar. Insertion times for GlideScope and Macintosh video laryngoscopes were similar, but were longer than those for the McGrath MAC X-Blade video laryngoscope (p=0.02). Tracheal intubation took longer with the GlideScope video laryngoscope than with the other devices (p<0.001 and p=0.003). Mean arterial pressures after insertion increased significantly in Macintosh and GlideScope groups (p=0.004 and p=0.001, respectively) compared with post-induction values. Heart rates increased after insertion in all three groups compared with post-induction values (p<0.001). Need for optimisation manoeuvres and postoperative minor complications were comparable in all three groups. Conclusion Although all three devices are useful for normal or difficult intubation, cricoid pressure improved Cormack-Lehane grades of Macintosh and McGrath MAC X-Blade video laryngoscopes but statistically significantly worsened that of the GlideScope video laryngoscope. PMID:29359076

Impact Evaluation of an After-school Cooking Skills Program in a Disadvantaged Community: Back to Basics.

PubMed

Burrows, Tracy L; Lucas, Hannah; Morgan, Philip J; Bray, James; Collins, Clare E

2015-09-01

Few efficacious child obesity interventions have been converted into ongoing community programs in the after-school setting. The aim of this study was to evaluate the impact of phase 2 of the Back to Basics cooking club on dietary behaviours and fruit and vegetable variety in a population at risk of obesity at a low income school with > 10% indigenous population. Baseline and 3-month dietary intake and social cognitive theory (SCT) constructs were collected in 51 children, mean age 9 years, 61% female. McNemar tests were used for comparison of proportions between categorical variables. Cohen's d was used to compare effect sizes across different measures. Consumption of one or more fruit servings per day significantly increased from 41% to 67% (P = 0.02, d = 0.13) and there was a trend for increasing the weekly variety of fruit and vegetables. The SCT constructs assessed within the current study improved significantly (P < 0.05), with moderate to large effect sizes (d = 0.33-0.78). This study documents that a previous efficacious healthy lifestyle program can be adapted for use as an obesity prevention program addressing improvements in vegetable and fruit intakes in a low income community with a relatively high indigenous population.

A Patient-Centered Transitional Care Case Management Program: Taking Case Management to the Streets and Beyond.

PubMed

Lovelace, Derenda; Hancock, Diane; Hughes, Sabrina S; Wyche, Phyllis R; Jenkins, Claire; Logan, Cindy

In 2011, the Hunter Holmes McGuire Veterans Administration Medical Center (VAMC) in Richmond, VA, had a cumulative readmission rate and emergency department (ED) revisits for discharged Veterans of 1 in 5. In 2012, a transitional care program (TCP) was implemented to improve care coordination and outcomes among Veterans, with an emphasis on geriatric patients with chronic disease. This TCP was created with an interdisciplinary approach using intensive case management interventions, with a goal of reducing Veteran ED and hospital revisits by 30%. To examine the impact of the McGuire VAMC TCP on Veteran ED and hospital utilization and costs. Veterans being discharged to home following an inpatient admission, ED visit, and/or short rehab stay. The primary means of identifying patients for the program is through daily screening of the previous 24-hour admission and ED report, which the inpatient nurse practitioner performs. She completes an extensive review of each Veteran's electronic medical record to determine the number of ED visits and inpatient admissions at the VAMC and in the community. Initial criteria for consideration in the program included the following: more than two hospital admissions and/or ED visits in the past 90 days or at high risk for readmission based on a Care Assessment Need score of greater than 95. Two hundred Veterans participated in the program in fiscal year (FY) 2013, with 146 participating in FY 2014. A retrospective chart review of Veterans participating in the TCP in FYs 2013 and 2014 was conducted, with a focus on number of admissions and ED visits 90 days prior to admission to the TCP and 90 days following TCP admission. Average admission and ED costs for this VA were calculated to determine cost savings from pre- to post-90 days of admission and ED visits. Veterans who obtained TCP services in FYs 2013 and 2014 experienced a 67% decrease in hospital admissions and a 61% decrease in ED visits in the 90 days following participation in this program compared with the 90 days prior to participation. This produced an estimated net savings of $3,823,673 in medical center costs. In addition, registered nurse case managers (RN CMs) noted improved patient compliance and satisfaction with care and the licensed clinical social worker noted reduced caregiver burden. The results of this program demonstrate how using an interdisciplinary approach to develop patient-centered transition plans of care through intensive case management interventions improves resource utilization with substantial financial savings. This program represents a feasible option for other VAMCs as well as civilian hospitals seeking to provide cost-effective transitional care to patients upon discharge and prevent untimely readmissions. With an RN CM at the hub of patient care, this program successfully demonstrates the value of smooth care transitions.

Effects of a sleep education program with self-help treatment on sleeping patterns and daytime sleepiness in Japanese adolescents: A cluster randomized trial.

PubMed

Tamura, Norihisa; Tanaka, Hideki

2016-01-01

Subjective insufficient sleep and delayed sleep-wake patterns have been reported as the primary causes for daytime sleepiness, a reasonably significant and prevalent problem for adolescents worldwide. Systematic reviews have indicated that the success of sleep education programs has thus far been inconsistent, due to the lack of a tailored approach that allows for evaluation of individual differences in behavior patterns. One way to resolve this problem is to assess the individual sleep behaviors of adolescents by using a checklist containing the recommended behaviors for promoting sleep health. Such self-help education programs have already been implemented for elementary school children, school nurses and the elderly. The present study aimed to verify the effects of a sleep education program with supplementary self-help treatment, based on a checklist of sleep-promoting behaviors, in addition to evaluation of changes in sleeping patterns, sleep-promoting behaviors and daytime sleepiness in adolescents. A cluster randomized controlled trial involving 5 Japanese junior high schools was conducted, and 243 students (sleep education: n = 122; waiting list: n = 121; 50.6% female; 7th grade) were included in the final analysis. The sleep education group was provided with information on proper sleep health and sleep-promoting behaviors. The students in this group were asked to practice one sleep-promoting behavior as a goal for 2 weeks and to monitor their practice using sleep diaries. Both pre- and post-treatment questionnaires were administered to students in order to assess knowledge of sleep-promoting behaviors, sleeping patterns and daytime functioning. Students in the sleep education group showed significant improvement in their knowledge of sleep health (F1,121 = 648.05, p < 0.001) and in their sleep-promoting behaviors (F1,121 = 55.66, p < 0.001). Bedtime on both school nights (F1,121 = 50.86, p < 0.001) and weekends (F1,121 = 15.03, p < 0.001), sleep-onset latency (F1,121 = 10.26, p = 0.002), total sleep time on school nights (F1,121 = 12.45, p = 0.001), subjective experience of insufficient sleep (McNemar χ(2)(1) = 4.03, p = 0.045) and daytime sleepiness (McNemar χ(2)(1) = 4.23, p = 0.040) were also improved in the sleep education group. In contrast, no significant improvement in these variables was observed for students in the waiting-list group. In conclusion, the sleep education program with self-help treatment was effective not only in increasing sleep knowledge but also in improving sleep-promoting behavior and sleeping patterns/reducing daytime sleepiness for students in the sleep education group, in comparison with the waiting-list group.

SU-E-T-535: Proton Dose Calculations in Homogeneous Media.

PubMed

Chapman, J; Fontenot, J; Newhauser, W; Hogstrom, K

2012-06-01

To develop a pencil beam dose calculation algorithm for scanned proton beams that improves modeling of scatter events. Our pencil beam algorithm (PBA) was developed for calculating dose from monoenergetic, parallel proton beams in homogeneous media. Fermi-Eyges theory was implemented for pencil beam transport. Elastic and nonelastic scatter effects were each modeled as a Gaussian distribution, with root mean square (RMS) widths determined from theoretical calculations and a nonlinear fit to a Monte Carlo (MC) simulated 1mm × 1mm proton beam, respectively. The PBA was commissioned using MC simulations in a flat water phantom. Resulting PBA calculations were compared with results of other models reported in the literature on the basis of differences between PBA and MC calculations of 80-20% penumbral widths. Our model was further tested by comparing PBA and MC results for oblique beams (45 degree incidence) and surface irregularities (step heights of 1 and 4 cm) for energies of 50-250 MeV and field sizes of 4cm × 4cm and 10cm × 10cm. Agreement between PBA and MC distributions was quantified by computing the percentage of points within 2% dose difference or 1mm distance to agreement. Our PBA improved agreement between calculated and simulated penumbral widths by an order of magnitude compared with previously reported values. For comparisons of oblique beams and surface irregularities, agreement between PBA and MC distributions was better than 99%. Our algorithm showed improved accuracy over other models reported in the literature in predicting the overall shape of the lateral profile through the Bragg peak. This improvement was achieved by incorporating nonelastic scatter events into our PBA. The increased modeling accuracy of our PBA, incorporated into a treatment planning system, may improve the reliability of treatment planning calculations for patient treatments. This research was supported by contract W81XWH-10-1-0005 awarded by The U.S. Army Research Acquisition Activity, 820 Chandler Street, Fort Detrick, MD 21702-5014. This report does not necessarily reflect the position or policy of the Government, and no official endorsement should be inferred. © 2012 American Association of Physicists in Medicine.

Improving the sampling efficiency of Monte Carlo molecular simulations: an evolutionary approach

NASA Astrophysics Data System (ADS)

Leblanc, Benoit; Braunschweig, Bertrand; Toulhoat, Hervé; Lutton, Evelyne

We present a new approach in order to improve the convergence of Monte Carlo (MC) simulations of molecular systems belonging to complex energetic landscapes: the problem is redefined in terms of the dynamic allocation of MC move frequencies depending on their past efficiency, measured with respect to a relevant sampling criterion. We introduce various empirical criteria with the aim of accounting for the proper convergence in phase space sampling. The dynamic allocation is performed over parallel simulations by means of a new evolutionary algorithm involving 'immortal' individuals. The method is bench marked with respect to conventional procedures on a model for melt linear polyethylene. We record significant improvement in sampling efficiencies, thus in computational load, while the optimal sets of move frequencies are liable to allow interesting physical insights into the particular systems simulated. This last aspect should provide a new tool for designing more efficient new MC moves.

Fast GPU-based Monte Carlo code for SPECT/CT reconstructions generates improved 177Lu images.

PubMed

Rydén, T; Heydorn Lagerlöf, J; Hemmingsson, J; Marin, I; Svensson, J; Båth, M; Gjertsson, P; Bernhardt, P

2018-01-04

Full Monte Carlo (MC)-based SPECT reconstructions have a strong potential for correcting for image degrading factors, but the reconstruction times are long. The objective of this study was to develop a highly parallel Monte Carlo code for fast, ordered subset expectation maximum (OSEM) reconstructions of SPECT/CT images. The MC code was written in the Compute Unified Device Architecture language for a computer with four graphics processing units (GPUs) (GeForce GTX Titan X, Nvidia, USA). This enabled simulations of parallel photon emissions from the voxels matrix (128 3 or 256 3 ). Each computed tomography (CT) number was converted to attenuation coefficients for photo absorption, coherent scattering, and incoherent scattering. For photon scattering, the deflection angle was determined by the differential scattering cross sections. An angular response function was developed and used to model the accepted angles for photon interaction with the crystal, and a detector scattering kernel was used for modeling the photon scattering in the detector. Predefined energy and spatial resolution kernels for the crystal were used. The MC code was implemented in the OSEM reconstruction of clinical and phantom 177 Lu SPECT/CT images. The Jaszczak image quality phantom was used to evaluate the performance of the MC reconstruction in comparison with attenuated corrected (AC) OSEM reconstructions and attenuated corrected OSEM reconstructions with resolution recovery corrections (RRC). The performance of the MC code was 3200 million photons/s. The required number of photons emitted per voxel to obtain a sufficiently low noise level in the simulated image was 200 for a 128 3 voxel matrix. With this number of emitted photons/voxel, the MC-based OSEM reconstruction with ten subsets was performed within 20 s/iteration. The images converged after around six iterations. Therefore, the reconstruction time was around 3 min. The activity recovery for the spheres in the Jaszczak phantom was clearly improved with MC-based OSEM reconstruction, e.g., the activity recovery was 88% for the largest sphere, while it was 66% for AC-OSEM and 79% for RRC-OSEM. The GPU-based MC code generated an MC-based SPECT/CT reconstruction within a few minutes, and reconstructed patient images of 177 Lu-DOTATATE treatments revealed clearly improved resolution and contrast.

Monitoring and Evaluation of Smolt Migration in the Columbia Basin : Volume XV : Evaluation of the 2007 Predictions of the Run-Timing of Wild and Hatchery-Reared Salmon and Steelhead Smolts to Rock Island, Lower Granite, McNary, John Day, and Bonneville Dams using Program RealTime.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Griswold, Jim; Townsend, Richard L.; Skalski, John R.

Program RealTime provided monitoring and forecasting of the 2007 inseason outmigrations via the internet for 26 PIT-tagged stocks of wild ESU Chinook salmon and steelhead to Lower Granite and/or McNary dams, one PIT-tagged hatchery-reared ESU of sockeye salmon to Lower Granite Dam, one PIT-tagged wild stock of sockeye salmon to McNary Dam, and 20 passage-indexed runs-at-large, five each to Rock Island, McNary, John Day, and Bonneville dams. Nineteen stocks are of wild yearling Chinook salmon which were captured, PIT-tagged, and released at sites above Lower Granite Dam in 2007 and have at least one year's historical migration data previous tomore » the 2007 migration. These stocks originate in 19 tributaries of the Salmon, Grande Ronde and Clearwater Rivers, all tributaries to the Snake River, and are subsequently detected through tag identification and monitored at Lower Granite Dam. Seven wild PIT-tagged runs-at-large of Snake or Upper Columbia River ESU salmon and steelhead were monitored at McNary Dam. Three wild PIT-tagged runs-at-large were monitored at Lower Granite Dam, consisting of the yearling and subyearling Chinook salmon and the steelhead runs. The hatchery-reared PIT-tagged sockeye salmon stock from Redfish Lake was monitored outmigrating through Lower Granite Dam. Passage-indexed stocks (stocks monitored by FPC passage indices) included combined wild and hatchery runs-at-large of subyearling and yearling Chinook, coho, and sockeye salmon, and steelhead forecasted to Rock Island, McNary, John Day, and Bonneville dams.« less

Development and analysis of insulation constructions for aerospace wiring applications

NASA Astrophysics Data System (ADS)

Slenski, George A.; Woodford, Lynn M.

1993-03-01

The Wright Laboratory Materials Directorate at WPAFB, Ohio recently completed a research and development program under contract with the McDonnell Douglas Aerospace Company, St. Louis, Missouri. Program objectives were to develop wire insulation performance requirements, evaluate candidate insulations, and prepare preliminary specification sheets on the most promising candidates. Aircraft wiring continues to be a high maintenance item and a major contributor to electrically-related aircraft mishaps. Mishap data on aircraft show that chafing of insulation is the most common mode of wire failure. Improved wiring constructions are expected to increase aircraft performance and decrease costs by reducing maintenance actions. In the laboratory program, new insulation constructions were identified that had overall improved performance in evaluation tests when compared to currently available MIL-W-81381 and MIL-W-22759 wiring. These insulations are principally aromatic polyimide and crosslinked ethylene tetrafluoroethylene (ETFE), respectively. Candidate insulations identified in preliminary specification sheets were principally fluoropolymers with a polyimide inner layer. Examples of insulation properties evaluated included flammability, high temperature mechanical and electrical performance, fluid immersion, and susceptibility to arc propagation under applied power chafing conditions. Potential next generation wire insulation materials are also reviewed.

Addressing education of speech-language pathologists in the World Report on Disability: development of a speech-language pathology program in Malaysia.

PubMed

Ahmad, Kartini; Ibrahim, Hasherah; Othman, Basyariatul Fathi; Vong, Etain

2013-02-01

The current paper is a response to the Wiley, McAllister, Davidson, and Marshall lead article regarding the application of the World Report on Disability (WRD) to people with communication disorders. The current paper directly addresses recommendation 5 (improvement of human resource capacity) and indirectly addresses recommendations 7, 8, and 9 (related to improving local knowledge and data on communicative disabilities) indirectly. The paper describes Malaysia's initiatives in the early 1990s, in developing its local professional capacity to provide services for people with communication disorders (PWCD). It charts the history of development of a local undergraduate entry-level degree program for speech-language pathology (SLP) from the point of conceptualization to full execution. The article provides glimpses to the processes and challenges faced by Universiti Kebangsaan Malaysia as the pioneer university in the South East Asia region to undertake the training and education of the SLP profession and highlights relevant issues faced by newly introduced professions in a country where resources and practice traditions were previously unavailable. It underscores the important role played by government institutions and an international professional network in driving forward-looking policies to implement and sustain the program.

Prognostic relevance of epithelial-mesenchymal transition and proliferation in surgically treated primary parotid gland cancer.

PubMed

Busch, Alina; Bauer, Larissa; Wardelmann, Eva; Rudack, Claudia; Grünewald, Inga; Stenner, Markus

2017-05-01

Cancer of the major salivary glands comprises a morphologically diverse group of rare tumours of largely unknown cause. Epithelial-mesenchymal transition (EMT) has been shown to play a significant prognostic role in various human cancers. The aim was to assess the expression of EMT markers in different histological subtypes of parotid gland cancer (PGC) and analyse their prognostic value. We examined 94 PGC samples (13 histological subtypes) for the expression of MIB-1, epithelial cadherin (E-cadherin), β-catenin, vimentin and cytokeratin 8/18 (CK8/18) by means of immunohistochemistry. The experimental findings were correlated with clinicopathological and survival parameters. We detected all analysed EMT and proliferation markers in specifically different constellations within the examined histological subtypes of PGC. We found high epithelial marker expressions (CK8/18, E-cadherin, membranous β-catenin) only in a distinct variety of carcinomas. A high proliferation rate (high MIB-1 expression) as well as a combination of high CK8/18 and low vimentin expression was associated with a significantly worse survival. Our findings indicate that activation of the EMT pathway is a relevant explanation for tumour progression in individual histological subtypes of malignant parotid gland lesions, but by far not in all. Evidence of EMT activation in PGC cannot be seen as an isolated prognostic factor. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Bs and Ds decay constants in three-flavor lattice QCD.

PubMed

Wingate, Matthew; Davies, Christine T H; Gray, Alan; Lepage, G Peter; Shigemitsu, Junko

2004-04-23

Capitalizing on recent advances in lattice QCD, we present a calculation of the leptonic decay constants f(B(s)) and f(D(s)) that includes effects of one strange sea quark and two light sea quarks via an improved staggered action. By shedding the quenched approximation and the associated lattice scale uncertainty, lattice QCD greatly increases its predictive power. Nonrelativistic QCD is used to simulate heavy quarks with masses between 1.5m(c) and m(b). We arrive at the following results: f(B(s))=260+/-7+/-26+/-8+/-5 and f(D(s))=290+/-20+/-29+/-29+/-6 MeV. The first quoted error is the statistical uncertainty, and the rest estimate the sizes of higher order terms neglected in this calculation. All of these uncertainties are systematically improvable by including another order in the weak coupling expansion, the nonrelativistic expansion, or the Symanzik improvement program.

Vertical Temperature Simulation of Pegasus Runway, McMurdo Station, Antarctica

DTIC Science & Technology

2015-01-01

Report Approved for public release; distribution is unlimited. Prepared for National Science Foundation , Division of Polar Programs, Antarctic...45 ERDC/CRREL TR-15-2 vii Preface This study was conducted for the National Science Foundation (NSF), Di- vision of Polar...Development Center GPR Ground-Penetrating Radar MIS McMurdo Ice Self NSF National Science Foundation PIR Precision Infrared Radiometer PLR Division of

ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT - ON-SITE GENERATION OF SODIUM HYPOCHLORITE CLORTEC, DIVISION OF CAPITAL CONTROLS, CLORTEC MODEL MC100 - NSF 00/16/EPADW395

EPA Science Inventory

THE EPA and NSF verified the performance of the ClorTec Model MC100 System under the EPA's ETV program. The concentrated hypochlorite generator stream from the treatment system underwent a twice-daily analysis from 3/8-4/6/00. The chlorine analyses were conducted onsite in United...

House Hearing Nunn-McCurdy Review of NPOESS

NASA Image and Video Library

2006-06-07

NOAA Administrator, Vice Admiral Conrad C. Lautenbacher, Jr., U.S. Navy (Ret.), testifies before the House Committee on Science and Technology regarding the future of the National Polar-orbiting Operational Environmental Satellite System (NPOESS) and results of the Nunn-McCurdy review of NOAA’s weather satellite program, Thursday, June 8, 2006, at the Rayburn House Office Building in Washington. Photo Credit: (NASA/Bill Ingalls)

House Hearing Nunn-McCurdy Review of NPOESS

NASA Image and Video Library

2006-06-07

Chairman of the House Committee on Science and Technology U.S. Rep. Sherwood Boehlert, R-N.Y., questions witnesses during a hearing on the future of the National Polar-orbiting Operational Environmental Satellite System (NPOESS) and results of the Nunn-McCurdy review of NOAA’s weather satellite program, Thursday, June 8, 2006, at the Rayburn House Office Building in Washington. Photo Credit: (NASA/Bill Ingalls)

Integration of Old and New Technology: Computers, Photography, and Video Technology in an Even Start Family Literacy Project.

ERIC Educational Resources Information Center

Landerholm, Elizabeth

McCosh Even Start is a federally funded project at McCosh School in an inner-city Chicago neighborhood and is administered as a partnership between Northeastern Illinois University and the Chicago Public Schools. The program's goals are to help parents: (1) become involved with the school by becoming comfortable at the school, making friends, and…

Assessment of Institutional and Personnel-Related Challenges Facing Educational Programme for the Mentally Challenged Persons at Kaimosi Special School, Kenya

ERIC Educational Resources Information Center

Mmbwanga, Daniel M.; Matemba, Collins K.; Bota, Kennedy N.

2015-01-01

The mentally challenged child (MC) can achieve a lot if the right environment and curriculum are designed for him/her. However, the realization of the desirable outcomes faces many challenges. The objective of the study was to examine institutional and personnel-related challenges facing education programs for the MC persons at Kaimosi Special…

Transforming Effective Army Units: Best Practices and Lessons Learned

DTIC Science & Technology

2013-08-01

Unlimited 106 Dorothy Young 703-545-2316 ii iii Technical Report 1326 Effective Army Units: Best Practices and Lessons Learned...SBCT units at Joint Base Lewis -McChord (JBLM), and two civilian subject matter experts on transformation from the Program Manager (PM) Stryker and...ISR Intelligence, Surveillance, Reconnaissance JBLM Joint Base Lewis -McChord JRTC Joint Readiness Training Center A-2 LNO Liaison

Removing Bureaucracy

DTIC Science & Technology

2015-08-01

11 Defense AT&L: July–August 2015 Removing Bureaucracy Katharina G. McFarland McFarland is Assistant Secretary of Defense for Acquisition. I once...involvement from all of the Service warfighting areas came together to scrub the program requirements due to concern over the “ bureaucracy ” and... Bureaucracy ” that focuses on reducing cycle time, staffing time and all forms of inefficiencies. This includes review of those burdens that Congress

Central role for melanocortin-4 receptors in offspring hypertension arising from maternal obesity

PubMed Central

Samuelsson, Anne-Maj S.; Mullier, Amandine; Maicas, Nuria; Oosterhuis, Nynke R.; Eun Bae, Sung; Novoselova, Tatiana V.; Chan, Li F.; Pombo, Joaquim M.; Taylor, Paul D.; Joles, Jaap A.; Coen, Clive W.; Balthasar, Nina; Poston, Lucilla

2016-01-01

Melanocortin-4 receptor (Mc4r)–expressing neurons in the autonomic nervous system, particularly in the paraventricular nucleus of the hypothalamus (PVH), play an essential role in blood pressure (BP) control. Mc4r-deficient (Mc4rKO) mice are severely obese but lack obesity-related hypertension; they also show a reduced pressor response to salt loading. We have previously reported that lean juvenile offspring born to diet-induced obese rats (OffOb) exhibit sympathetic-mediated hypertension, and we proposed a role for postnatally raised leptin in its etiology. Here, we test the hypothesis that neonatal hyperleptinemia due to maternal obesity induces persistent changes in the central melanocortin system, thereby contributing to offspring hypertension. Working on the OffOb paradigm in both sexes and using transgenic technology to restore Mc4r in the PVH of Mc4rKO (Mc4rPVH) mice, we have now shown that these mice develop higher BP than Mc4rKO or WT mice. We have also found that experimental hyperleptinemia induced in the neonatal period in Mc4rPVH and WT mice, but not in the Mc4rKO mice, leads to heightened BP and severe renal dysfunction. Thus, Mc4r in the PVH appears to be required for early-life programming of hypertension arising from either maternal obesity or neonatal hyperleptinemia. Early-life exposure of the PVH to maternal obesity through postnatal elevation of leptin may have long-term consequences for cardiovascular health. PMID:27791019

Building Community through Arts Experiences.

ERIC Educational Resources Information Center

Arnold, Alice

1994-01-01

Asserts that society is fragmented and there is a need for strong support networks. Describes a cooperative community building program in North Carolina involving East Carolina University's art education program, Greenville (NC) public schools, and the McDonalds corporation. (CFR)

Disparities in Aesthetic Procedures Performed by Plastic Surgery Residents.

PubMed

Silvestre, Jason; Serletti, Joseph M; Chang, Benjamin

2017-05-01

Operative experience in aesthetic surgery is an important issue affecting plastic surgery residents. This study addresses the variability of aesthetic surgery experience during plastic surgery residency. National operative case logs of chief residents in independent/combined and integrated plastic surgery residency programs were analyzed (2011-2015). Fold differences between the bottom and top 10th percentiles of residents were calculated for each aesthetic procedure category and training model. The number of residents not achieving case minimums was also calculated. Case logs of 818 plastic surgery residents were analyzed. There was marked variability in craniofacial (range, 6.0-15.0), breast (range, 2.4-5.9), trunk/extremity (range, 3.0-16.0), and miscellaneous (range, 2.7-22.0) procedure categories. In 2015, the bottom 10th percentile of integrated and independent/combined residents did not achieve case minimums for botulinum toxin and dermal fillers. Case minimums were achieved for the other aesthetic procedure categories for all graduating years. Significant variability persists for many aesthetic procedure categories during plastic surgery residency training. Greater efforts may be needed to improve the aesthetic surgery experience of plastic surgery residents. © 2016 The American Society for Aesthetic Plastic Surgery, Inc. Reprints and permission: journals.permissions@oup.com

Sunburn prevalence among adults--United States, 1999, 2003, and 2004.

PubMed

2007-06-01

Episodic acute overexposure to ultraviolet (UV) radiation (i.e., sunburn) is an important risk factor for two types of skin cancer: basal cell carcinoma and melanoma. Melanoma is the most lethal type of skin cancer. In 2003, a total of 45,625 new cases of melanoma were diagnosed in the United States, and 7,818 persons died from the disease. A meta-analysis of 57 studies indicated that the relative risk for melanoma among persons with sunburn history compared with those without sunburn history was 2.03 (95% confidence interval [CI] = 1.73-2.37). Monitoring sunburn prevalence with population-based surveys allows an estimate of compliance with sun-protection behaviors, assessments of risk for developing skin cancer, and measurement of the success of prevention programs. To evaluate trends in sunburn prevalence among U.S. adults, CDC analyzed cross-sectional data from the 1999, 2003, and 2004 Behavioral Risk Factor Surveillance System (BRFSS) surveys. This report describes the results of that analysis, which indicated that sunburn prevalence among all adults increased from 31.8% in 1999 to 33.7% in 2004. Further research is needed to determine which interventions will best improve sun-protection behaviors among the public.

CAST: a new program package for the accurate characterization of large and flexible molecular systems.

PubMed

Grebner, Christoph; Becker, Johannes; Weber, Daniel; Bellinger, Daniel; Tafipolski, Maxim; Brückner, Charlotte; Engels, Bernd

2014-09-15

The presented program package, Conformational Analysis and Search Tool (CAST) allows the accurate treatment of large and flexible (macro) molecular systems. For the determination of thermally accessible minima CAST offers the newly developed TabuSearch algorithm, but algorithms such as Monte Carlo (MC), MC with minimization, and molecular dynamics are implemented as well. For the determination of reaction paths, CAST provides the PathOpt, the Nudge Elastic band, and the umbrella sampling approach. Access to free energies is possible through the free energy perturbation approach. Along with a number of standard force fields, a newly developed symmetry-adapted perturbation theory-based force field is included. Semiempirical computations are possible through DFTB+ and MOPAC interfaces. For calculations based on density functional theory, a Message Passing Interface (MPI) interface to the Graphics Processing Unit (GPU)-accelerated TeraChem program is available. The program is available on request. Copyright © 2014 Wiley Periodicals, Inc.

Physical therapy treatment effectiveness for osteoarthritis of the knee: a randomized comparison of supervised clinical exercise and manual therapy procedures versus a home exercise program.

PubMed

Deyle, Gail D; Allison, Stephen C; Matekel, Robert L; Ryder, Michael G; Stang, John M; Gohdes, David D; Hutton, Jeremy P; Henderson, Nancy E; Garber, Matthew B

2005-12-01

Manual therapy and exercise have not previously been compared with a home exercise program for patients with osteoarthritis (OA) of the knee. The purpose of this study was to compare outcomes between a home-based physical therapy program and a clinically based physical therapy program. One hundred thirty-four subjects with OA of the knee were randomly assigned to a clinic treatment group (n=66; 61% female, 39% male; mean age [+/-SD]=64+/-10 years) or a home exercise group (n=68, 71% female, 29% male; mean age [+/-SD]=62+/-9 years). Subjects in the clinic treatment group received supervised exercise, individualized manual therapy, and a home exercise program over a 4-week period. Subjects in the home exercise group received the same home exercise program initially, reinforced at a clinic visit 2 weeks later. Measured outcomes were the distance walked in 6 minutes and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Both groups showed clinically and statistically significant improvements in 6-minute walk distances and WOMAC scores at 4 weeks; improvements were still evident in both groups at 8 weeks. By 4 weeks, WOMAC scores had improved by 52% in the clinic treatment group and by 26% in the home exercise group. Average 6-minute walk distances had improved about 10% in both groups. At 1 year, both groups were substantially and about equally improved over baseline measurements. Subjects in the clinic treatment group were less likely to be taking medications for their arthritis and were more satisfied with the overall outcome of their rehabilitative treatment compared with subjects in the home exercise group. Although both groups improved by 1 month, subjects in the clinic treatment group achieved about twice as much improvement in WOMAC scores than subjects who performed similar unsupervised exercises at home. Equivalent maintenance of improvements at 1 year was presumably due to both groups continuing the identical home exercise program. The results indicate that a home exercise program for patients with OA of the knee provides important benefit. Adding a small number of additional clinical visits for the application of manual therapy and supervised exercise adds greater symptomatic relief.

Pre-Concentration for Improved Long-Term Monitoring of Contaminants in Groundwater

DTIC Science & Technology

2009-01-01

Inorganic/Organic Frameworks. Chem. Mater. 11 (1999) 3302-3308. [14] M.C. Burleigh, M.A. Markowitz, M.S. Spector, and B.P. Gaber , Porous organosilicas...Mitigation. (2008). [20] M.C. Burleigh, M.A. Markowitz, M.S. Spector, and B.P. Gaber , Porous polysilsesquioxanes for the adsorption of phenols...chromatography. Journal of Chromatography A 771 (1997) 145-154. [24] M.C. Burleigh, M.A. Markowitz, M.S. Spector, and B.P. Gaber , Porous polysilsesquioxanes

The NASA/industry Design Analysis Methods for Vibrations (DAMVIBS) program: McDonnell-Douglas Helicopter Company achievements

NASA Technical Reports Server (NTRS)

Toossi, Mostafa; Weisenburger, Richard; Hashemi-Kia, Mostafa

1993-01-01

This paper presents a summary of some of the work performed by McDonnell Douglas Helicopter Company under NASA Langley-sponsored rotorcraft structural dynamics program known as DAMVIBS (Design Analysis Methods for VIBrationS). A set of guidelines which is applicable to dynamic modeling, analysis, testing, and correlation of both helicopter airframes and a large variety of structural finite element models is presented. Utilization of these guidelines and the key features of their applications to vibration modeling of helicopter airframes are discussed. Correlation studies with the test data, together with the development and applications of a set of efficient finite element model checkout procedures, are demonstrated on a large helicopter airframe finite element model. Finally, the lessons learned and the benefits resulting from this program are summarized.

Assessment of an introductory cervicocerebral catheter angiography learning program: a pilot study.

PubMed

Lui, Y W; Farinhas, J M; Basalely, A M; Hsu, K A; Freeman, K; Bello, J A

2012-06-01

There is no standardized curriculum currently available at most institutions for establishing procedural competency in trainees performing cervicocerebral angiography. The purpose of this study was to evaluate a simple learning program to supplement the teaching of basic cervicocerebral angiography. An 11-session interactive curriculum was implemented covering anatomic, clinical, and radiographic topics for the novice cervicocerebral angiographer. The target learner was the neuroradiology fellow. Data were gathered regarding fellow comfort level on topics relating to cervicocerebral angiography by using a 5-point Likert scale. Improvement in scores on knowledge-based questions after completion of the curriculum was calculated (McNemar test). Trainee-perceived utility of the program was also recorded by using a 5-point Likert scale. Focus sessions were held at the completion of the curriculum to gather feedback regarding the strengths and weaknesses of the program from participants. Ten subjects were enrolled in this pilot study for 3 years. Topics where participants reported a poor initial comfort level (4 or higher) included selection of injection rates and volumes and reformation of reverse-curve catheters. Trainees demonstrated a statistically significant change in the distribution of scores of 29.3% (49.4%-78.7% correct response rate, P < .0001). The average perceived utility was 1.5 (1 = most useful, 5 = least useful). This simple learning program was a useful adjunct to the training of fellows in diagnostic cervicocerebral angiography, resulting in quantitative improvements in knowledge.

Automated movement correction for dynamic PET/CT images: evaluation with phantom and patient data.

PubMed

Ye, Hu; Wong, Koon-Pong; Wardak, Mirwais; Dahlbom, Magnus; Kepe, Vladimir; Barrio, Jorge R; Nelson, Linda D; Small, Gary W; Huang, Sung-Cheng

2014-01-01

Head movement during a dynamic brain PET/CT imaging results in mismatch between CT and dynamic PET images. It can cause artifacts in CT-based attenuation corrected PET images, thus affecting both the qualitative and quantitative aspects of the dynamic PET images and the derived parametric images. In this study, we developed an automated retrospective image-based movement correction (MC) procedure. The MC method first registered the CT image to each dynamic PET frames, then re-reconstructed the PET frames with CT-based attenuation correction, and finally re-aligned all the PET frames to the same position. We evaluated the MC method's performance on the Hoffman phantom and dynamic FDDNP and FDG PET/CT images of patients with neurodegenerative disease or with poor compliance. Dynamic FDDNP PET/CT images (65 min) were obtained from 12 patients and dynamic FDG PET/CT images (60 min) were obtained from 6 patients. Logan analysis with cerebellum as the reference region was used to generate regional distribution volume ratio (DVR) for FDDNP scan before and after MC. For FDG studies, the image derived input function was used to generate parametric image of FDG uptake constant (Ki) before and after MC. Phantom study showed high accuracy of registration between PET and CT and improved PET images after MC. In patient study, head movement was observed in all subjects, especially in late PET frames with an average displacement of 6.92 mm. The z-direction translation (average maximum = 5.32 mm) and x-axis rotation (average maximum = 5.19 degrees) occurred most frequently. Image artifacts were significantly diminished after MC. There were significant differences (P<0.05) in the FDDNP DVR and FDG Ki values in the parietal and temporal regions after MC. In conclusion, MC applied to dynamic brain FDDNP and FDG PET/CT scans could improve the qualitative and quantitative aspects of images of both tracers.

Automated Movement Correction for Dynamic PET/CT Images: Evaluation with Phantom and Patient Data

PubMed Central

Ye, Hu; Wong, Koon-Pong; Wardak, Mirwais; Dahlbom, Magnus; Kepe, Vladimir; Barrio, Jorge R.; Nelson, Linda D.; Small, Gary W.; Huang, Sung-Cheng

2014-01-01

Head movement during a dynamic brain PET/CT imaging results in mismatch between CT and dynamic PET images. It can cause artifacts in CT-based attenuation corrected PET images, thus affecting both the qualitative and quantitative aspects of the dynamic PET images and the derived parametric images. In this study, we developed an automated retrospective image-based movement correction (MC) procedure. The MC method first registered the CT image to each dynamic PET frames, then re-reconstructed the PET frames with CT-based attenuation correction, and finally re-aligned all the PET frames to the same position. We evaluated the MC method's performance on the Hoffman phantom and dynamic FDDNP and FDG PET/CT images of patients with neurodegenerative disease or with poor compliance. Dynamic FDDNP PET/CT images (65 min) were obtained from 12 patients and dynamic FDG PET/CT images (60 min) were obtained from 6 patients. Logan analysis with cerebellum as the reference region was used to generate regional distribution volume ratio (DVR) for FDDNP scan before and after MC. For FDG studies, the image derived input function was used to generate parametric image of FDG uptake constant (Ki) before and after MC. Phantom study showed high accuracy of registration between PET and CT and improved PET images after MC. In patient study, head movement was observed in all subjects, especially in late PET frames with an average displacement of 6.92 mm. The z-direction translation (average maximum = 5.32 mm) and x-axis rotation (average maximum = 5.19 degrees) occurred most frequently. Image artifacts were significantly diminished after MC. There were significant differences (P<0.05) in the FDDNP DVR and FDG Ki values in the parietal and temporal regions after MC. In conclusion, MC applied to dynamic brain FDDNP and FDG PET/CT scans could improve the qualitative and quantitative aspects of images of both tracers. PMID:25111700

A new approach to integrate GPU-based Monte Carlo simulation into inverse treatment plan optimization for proton therapy.

PubMed

Li, Yongbao; Tian, Zhen; Song, Ting; Wu, Zhaoxia; Liu, Yaqiang; Jiang, Steve; Jia, Xun

2017-01-07

Monte Carlo (MC)-based spot dose calculation is highly desired for inverse treatment planning in proton therapy because of its accuracy. Recent studies on biological optimization have also indicated the use of MC methods to compute relevant quantities of interest, e.g. linear energy transfer. Although GPU-based MC engines have been developed to address inverse optimization problems, their efficiency still needs to be improved. Also, the use of a large number of GPUs in MC calculation is not favorable for clinical applications. The previously proposed adaptive particle sampling (APS) method can improve the efficiency of MC-based inverse optimization by using the computationally expensive MC simulation more effectively. This method is more efficient than the conventional approach that performs spot dose calculation and optimization in two sequential steps. In this paper, we propose a computational library to perform MC-based spot dose calculation on GPU with the APS scheme. The implemented APS method performs a non-uniform sampling of the particles from pencil beam spots during the optimization process, favoring those from the high intensity spots. The library also conducts two computationally intensive matrix-vector operations frequently used when solving an optimization problem. This library design allows a streamlined integration of the MC-based spot dose calculation into an existing proton therapy inverse planning process. We tested the developed library in a typical inverse optimization system with four patient cases. The library achieved the targeted functions by supporting inverse planning in various proton therapy schemes, e.g. single field uniform dose, 3D intensity modulated proton therapy, and distal edge tracking. The efficiency was 41.6  ±  15.3% higher than the use of a GPU-based MC package in a conventional calculation scheme. The total computation time ranged between 2 and 50 min on a single GPU card depending on the problem size.

A new approach to integrate GPU-based Monte Carlo simulation into inverse treatment plan optimization for proton therapy

NASA Astrophysics Data System (ADS)

Li, Yongbao; Tian, Zhen; Song, Ting; Wu, Zhaoxia; Liu, Yaqiang; Jiang, Steve; Jia, Xun

2017-01-01

Monte Carlo (MC)-based spot dose calculation is highly desired for inverse treatment planning in proton therapy because of its accuracy. Recent studies on biological optimization have also indicated the use of MC methods to compute relevant quantities of interest, e.g. linear energy transfer. Although GPU-based MC engines have been developed to address inverse optimization problems, their efficiency still needs to be improved. Also, the use of a large number of GPUs in MC calculation is not favorable for clinical applications. The previously proposed adaptive particle sampling (APS) method can improve the efficiency of MC-based inverse optimization by using the computationally expensive MC simulation more effectively. This method is more efficient than the conventional approach that performs spot dose calculation and optimization in two sequential steps. In this paper, we propose a computational library to perform MC-based spot dose calculation on GPU with the APS scheme. The implemented APS method performs a non-uniform sampling of the particles from pencil beam spots during the optimization process, favoring those from the high intensity spots. The library also conducts two computationally intensive matrix-vector operations frequently used when solving an optimization problem. This library design allows a streamlined integration of the MC-based spot dose calculation into an existing proton therapy inverse planning process. We tested the developed library in a typical inverse optimization system with four patient cases. The library achieved the targeted functions by supporting inverse planning in various proton therapy schemes, e.g. single field uniform dose, 3D intensity modulated proton therapy, and distal edge tracking. The efficiency was 41.6  ±  15.3% higher than the use of a GPU-based MC package in a conventional calculation scheme. The total computation time ranged between 2 and 50 min on a single GPU card depending on the problem size.

A New Approach to Integrate GPU-based Monte Carlo Simulation into Inverse Treatment Plan Optimization for Proton Therapy

PubMed Central

Li, Yongbao; Tian, Zhen; Song, Ting; Wu, Zhaoxia; Liu, Yaqiang; Jiang, Steve; Jia, Xun

2016-01-01

Monte Carlo (MC)-based spot dose calculation is highly desired for inverse treatment planning in proton therapy because of its accuracy. Recent studies on biological optimization have also indicated the use of MC methods to compute relevant quantities of interest, e.g. linear energy transfer. Although GPU-based MC engines have been developed to address inverse optimization problems, their efficiency still needs to be improved. Also, the use of a large number of GPUs in MC calculation is not favorable for clinical applications. The previously proposed adaptive particle sampling (APS) method can improve the efficiency of MC-based inverse optimization by using the computationally expensive MC simulation more effectively. This method is more efficient than the conventional approach that performs spot dose calculation and optimization in two sequential steps. In this paper, we propose a computational library to perform MC-based spot dose calculation on GPU with the APS scheme. The implemented APS method performs a non-uniform sampling of the particles from pencil beam spots during the optimization process, favoring those from the high intensity spots. The library also conducts two computationally intensive matrix-vector operations frequently used when solving an optimization problem. This library design allows a streamlined integration of the MC-based spot dose calculation into an existing proton therapy inverse planning process. We tested the developed library in a typical inverse optimization system with four patient cases. The library achieved the targeted functions by supporting inverse planning in various proton therapy schemes, e.g. single field uniform dose, 3D intensity modulated proton therapy, and distal edge tracking. The efficiency was 41.6±15.3% higher than the use of a GPU-based MC package in a conventional calculation scheme. The total computation time ranged between 2 and 50 min on a single GPU card depending on the problem size. PMID:27991456

How to Increase the Number of Minority Ph.D.s.

ERIC Educational Resources Information Center

Wagener, Ursula

1991-01-01

The article considers efforts to increase the number of minority persons, especially African Americans, earning doctoral degrees and describes the McKnight Doctoral Fellowship Program at the University of Florida which has provided 167 doctoral fellowships. This program illustrates essential program components: aggressive recruitment; constant,…

School Library Media Program Connections for Learning.

ERIC Educational Resources Information Center

Bookmark, 1991

1991-01-01

The 29 articles in this theme issue of "The Bookmark" focus on various aspects of school library media programs. The articles are as follows: (1) "School Library Media Program Connections for Learning" (Betty J. Morris); (2) "Humanity and Technology in the School of the Future" (Michael V. McGill); (3) "Community…

34 CFR 647.4 - What activities and services may a project provide?

Code of Federal Regulations, 2010 CFR

2010-07-01

... PROGRAM General § 647.4 What activities and services may a project provide? A McNair project may provide... activities designed to prepare participants for doctoral study. (d) Tutoring. (e) Academic counseling. (f... programs. (g) Mentoring programs involving faculty members or students at institutions of higher education...

The McNair Program as a Socializing Influence on Doctoral Degree Attainment

ERIC Educational Resources Information Center

Gittens, Cheryl Bailey

2014-01-01

The quality of doctoral students' academic and social experiences is a key element of their success in graduate school programs. These experiences support the completion of doctoral programs, especially for first-generation college students from low-income backgrounds. Framed by Weidman's (1989) undergraduate socialization model, the author…

50 CFR 223.102 - Enumeration of threatened marine and anadromous species.

Code of Federal Regulations, 2014 CFR

2014-10-01

...; Imnaha River Program; Big Sheep Creek Program; McCall Hatchery Program; Johnson Creek Artificial... the U.S. Virgin Islands, and Cuba's EEZ, and further delineated by the following boundary lines... Aptos Creek, and all drainages of San Francisco and San Pablo Bays eastward to Chipps Island at the...

Improving queuing service at McDonald's

NASA Astrophysics Data System (ADS)

Koh, Hock Lye; Teh, Su Yean; Wong, Chin Keat; Lim, Hooi Kie; Migin, Melissa W.

2014-07-01

Fast food restaurants are popular among price-sensitive youths and working adults who value the conducive environment and convenient services. McDonald's chains of restaurants promote their sales during lunch hours by offering package meals which are perceived to be inexpensive. These promotional lunch meals attract good response, resulting in occasional long queues and inconvenient waiting times. A study is conducted to monitor the distribution of waiting time, queue length, customer arrival and departure patterns at a McDonald's restaurant located in Kuala Lumpur. A customer survey is conducted to gauge customers' satisfaction regarding waiting time and queue length. An android app named Que is developed to perform onsite queuing analysis and report key performance indices. The queuing theory in Que is based upon the concept of Poisson distribution. In this paper, Que is utilized to perform queuing analysis at this McDonald's restaurant with the aim of improving customer service, with particular reference to reducing queuing time and shortening queue length. Some results will be presented.

Improving stroke knowledge through a 'volunteer-led' community education program in Australia.

PubMed

Kilkenny, Monique F; Purvis, Tara; Werner, Megan; Reyneke, Megan; Czerenkowski, Jude; Cadilhac, Dominique A

2016-05-01

Public awareness of stroke risks and warning signs remains poor. The National Stroke Foundation (NSF) in Australia has been undertaking a StrokeSafe Ambassador Education program to raise awareness of stroke. The format includes presentations by volunteers trained to be 'ambassadors' to spread standard information about stroke to the public. Our aim was to determine the change in knowledge of participants who attended presentations. Participants completed questionnaires before immediately after presentations, and at 3months following the presentation. Information was collected on knowledge of risk factors and signs of stroke. McNemar's test was used to compare paired-responses over time. A p value of <0.05 was considered significant. Between March and April 2014, 591 participants attended 185 presentations and 591 (100%) completed them before and immediately after presentation questionnaires: 68% were female and 75% were aged 65years or more. 258 consented for further follow-up with 192 completing follow-up. Comparing immediately after with before presentation showed significantly improved knowledge for all 10 stroke risk factors and all signs of stroke. Significantly improved knowledge for 7/10 risk factors and 1/3 signs of stroke was found when comparing follow-up and immediately after presentation results. Knowledge of 5/10 risk factors and 2/3 signs of stroke improved when comparing follow-up and before presentation. This study describes a novel approach to support the use of trained volunteers to provide a community-based, standardised education program for stroke. This program shows that community presentations can improve immediate and short-term knowledge of signs and risk factors for stroke. Copyright © 2016. Published by Elsevier Inc.

Ecological effects of contaminants in McCoy Branch, 1991--1993

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ryon, M.G.

1996-09-01

The 1984 Hazardous and Solid Waste Amendments to the Resource Conservation and Recovery Act (RCRA) required assessment of all current and former solid waste management units. Following guidelines under RCRA and the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), a remedial investigation (RI) was required of the Y-12 Plant for their filled coal ash pond (FCAP) and associated areas on McCoy Branch. The RI process was initiated and assessments were presented. Because the disposal of coal ash in the ash pond, McCoy Branch, and Rogers Quarry was not consistent with the Tennessee Water Quality Act, several remediation steps weremore » implemented between 1986 and 1994 for McCoy Branch to address disposal problems. The required ecological risk assessments of McCoy Branch watershed included provisions for biological monitoring of the watershed. The objectives of the biological monitoring were to (1) document changes in biological quality of McCoy Branch after completion of a pipeline bypassing upper McCoy Branch and further, after termination of all discharges to Rogers Quarry, (2) provide guidance on the need for additional remediation, and (3) evaluate the effectiveness of implemented remedial actions. The data from the biological monitoring program may also determine whether the goals of protection of human health and the environment of McCoy Branch are being accomplished.« less

Clinical outcome of nutrition-oriented intervention for primary intestinal lymphangiectasia.

PubMed

Tang, Qing-Ya; Wen, Jie; Wu, Jiang; Wang, Ying; Cai, Wei

2011-02-01

primary intestinal lymphangiectasia (PIL) is a rare digestive disease and few studies have focused on the therapeutic effect in PIL patients. This study was undertaken to evaluate nutrition-oriented intervention in children with PIL. four children with PIL were studied. Their medical records were reviewed. Anthropometric measurements and blood tests were performed during a 8-18 month follow-up. during hospitalization, the 4 patients were subjected to diet intervention. Parenteral nutrition (PN) support was also given to 3 of them. Clinical symptoms and laboratory parameters of the patients were significantly improved at discharge. After discharge, the patients continued diet control, 2 of whom received intermittent PN support. The mean follow-up duration of the 4 patients was 13 months (range, 8-18 months) and they all kept in a stable condition without symptoms relapse. Weight, height and body mass index for age were normal during the follow-up, while total protein, albumin and immunoglobulin concentrations were still slightly below normal level. nutrition therapy is effective as a valid and safe therapeutic management for PIL patients. No growth retardation was observed in the 4 children after the therapy, but they are still at risk of nutrient malabsorption. Therefore, they need long-term, regular monitoring and intensive nutritional care.

First-Year Students' Impressions of Pair Programming in CS1

ERIC Educational Resources Information Center

Simon, Beth; Hanks, Brian

2008-01-01

Pair programming, as part of the Agile Development process, has noted benefits in professional software development scenarios. These successes have led to a rise in use of pair programming in educational settings, particularly in Computer Science 1 (CS1). Specifically, McDowell et al. [2006] has shown that students using pair programming in CS1 do…

A system that 'walks the talk'. Using improved community health status for CEO evaluation and compensation. Interview by Karen Gardner.

PubMed

McMeekin, J C; Billings, R W

1994-04-01

Crozer-Keystone Health System, with corporate headquarters in Media, PA, is relatively new. The system was formed in 1990 to integrate four hospitals--roughly 1,160 acute care beds--five long-term care facilities, skilled nursing facilities and personal care facilities. According to President and CEO John C. McMeekin, the system comprises "very aggressive" programs in senior wellness, geriatric care, women's and children's health, behavioral medicine and psychiatric substance abuse. And it also has a large managed care organization that was undertaken as part of a joint venture with members of the hospitals' medical staff. The system is still defining itself, and perhaps that's why it has been willing to venture into an area that is virtually unique among health care organizations: using community health status indicators as part of the CEO's annual evaluation and compensation. Recently, Trustee editor Karen Gardner spoke to McMeekin and board Chairman Richard W. Billings about a major community needs assessment project that the system undertook in 1991 and how it is using the results of that study.

Aluminum Lithium Alloy 2195 Fusion Welding Improvements with New Filler Wire

NASA Technical Reports Server (NTRS)

Russell, Carolyn; Bjorkman, Gerry; McCool, Carolyn (Technical Monitor)

2000-01-01

A viewgraph presentation outlines NASA Marshall Space Flight Center, Lockheed Martin Michoud Space Systems, and McCook Metals' development an aluminum-copper weld filler wire for fusion welding 2195 aluminum lithium. The aluminum-copper based weld filler wire has been identified as B218, which is the result of six years of weld filler wire development funded by NASA, Lockheed Martin, and McCook Metals. The Super Lightweight External Tank for the NASA Space Shuttle Program consists of 2195 welded with 4043 aluminum-silicon weld filler wire. The B218 filler wire chemistry was developed to produce enhanced 2195 weld and repair weld mechanical properties. An initial characterization of the B218 weld filler wire was performed consisting of initial weld and repair weld evaluation comparing B218 and 4043. The testing involved room temperature and cryogenic tensile testing along with fracture toughness testing. B218 weld filler wire proved to produce enhanced initial and repair weld tensile and fracture properties over 4043. B218 weld filler wire has proved to be a superior weld filler wire for welding 2195 and other aluminum lithium alloys over 4043.

Predicting international medical graduate success on college certification examinations

PubMed Central

Schabort, Inge; Mercuri, Mathew; Grierson, Lawrence E.M.

2014-01-01

Abstract Objective To determine predictors of international medical graduate (IMG) success in accordance with the priorities highlighted by the Thomson and Cohl judicial report on IMG selection. Design Retrospective assessment using regression analyses to compare the information available at the time of resident selection with those trainees’ national certification examination outcomes. Setting McMaster University in Hamilton, Ont. Participants McMaster University IMG residents who completed the program between 2005 and 2011. Main outcome measures Associations between IMG professional experience or demographic characteristics and examination outcomes. Results The analyses revealed that country of study and performance on the Medical Council of Canada Evaluating Examination are among the predictors of performance on the College of Family Physicians of Canada and the Royal College of Physicians and Surgeons of Canada certification examinations. Of interest, the analyses also suggest discipline-specific relationships between previous professional experience and examination success. Conclusion This work presents a useful technique for further improving our understanding of the performance of IMGs on certification examinations in North America, encourages similar interinstitutional analyses, and provides a foundation for the development of tools to assist with IMG education. PMID:25316762

Feeding a Mixture of Choline Forms during Lactation Improves Offspring Growth and Maternal Lymphocyte Response to Ex Vivo Immune Challenges.

PubMed

Lewis, Erin D; Richard, Caroline; Goruk, Susan; Wadge, Emily; Curtis, Jonathan M; Jacobs, René L; Field, Catherine J

2017-07-07

Study objectives were to examine the impact of feeding a mixture of choline forms, or a diet high in glycerophosphocholine (GPC) on maternal immune function and offspring growth during lactation. Lactating Sprague-Dawley rat dams ( n = 6/diet) were randomized to one of three diets, providing 1 g/kg total choline: Control (100% free choline (FC)), Mixed Choline (MC; 50% phosphatidylcholine (PC), 25% FC, 25% GPC), or High GPC (HGPC; 75% GPC, 12.5% PC, 12.5% FC). At 3 weeks, cell phenotypes and cytokine production with Concanavalin A (ConA)-or lipopolysaccharide (LPS)-stimulated splenocytes and mesenteric lymphocytes were measured. Feeding MC or HGPC diets improved pups' growth compared to Control (+22% body weight, p < 0.05). In spleen, MC-and HGPC-fed dams had higher proportions of cytotoxic (CD8+) T cells expressing CD27, CD71 and CD127, total B cells (CD45RA+) and dendritic cells (OX6+OX62+), and produced less IL-6 and IFN-γ after ConA than Control-fed dams ( p < 0.05). MC and HGPC LPS-stimulated splenocytes produced less IL-1β and IL-6 than Control. ConA-stimulated mesenteric lymphocytes from MC and HGPC dams produced more IL-2 and IFN-γ than Control ( p < 0.05). In summary, feeding a mixture of choline forms during lactation improved offspring growth and resulted in a more efficient maternal immune response following mitogenic immune challenge.

Feeding a Mixture of Choline Forms during Lactation Improves Offspring Growth and Maternal Lymphocyte Response to Ex Vivo Immune Challenges

PubMed Central

Lewis, Erin D.; Goruk, Susan; Wadge, Emily; Curtis, Jonathan M.; Field, Catherine J.

2017-01-01

Study objectives were to examine the impact of feeding a mixture of choline forms, or a diet high in glycerophosphocholine (GPC) on maternal immune function and offspring growth during lactation. Lactating Sprague-Dawley rat dams (n = 6/diet) were randomized to one of three diets, providing 1 g/kg total choline: Control (100% free choline (FC)), Mixed Choline (MC; 50% phosphatidylcholine (PC), 25% FC, 25% GPC), or High GPC (HGPC; 75% GPC, 12.5% PC, 12.5% FC). At 3 weeks, cell phenotypes and cytokine production with Concanavalin A (ConA)-or lipopolysaccharide (LPS)-stimulated splenocytes and mesenteric lymphocytes were measured. Feeding MC or HGPC diets improved pups’ growth compared to Control (+22% body weight, p < 0.05). In spleen, MC-and HGPC-fed dams had higher proportions of cytotoxic (CD8+) T cells expressing CD27, CD71 and CD127, total B cells (CD45RA+) and dendritic cells (OX6+OX62+), and produced less IL-6 and IFN-γ after ConA than Control-fed dams (p < 0.05). MC and HGPC LPS-stimulated splenocytes produced less IL-1β and IL-6 than Control. ConA-stimulated mesenteric lymphocytes from MC and HGPC dams produced more IL-2 and IFN-γ than Control (p < 0.05). In summary, feeding a mixture of choline forms during lactation improved offspring growth and resulted in a more efficient maternal immune response following mitogenic immune challenge. PMID:28686201

CheckMATE 2: From the model to the limit

NASA Astrophysics Data System (ADS)

Dercks, Daniel; Desai, Nishita; Kim, Jong Soo; Rolbiecki, Krzysztof; Tattersall, Jamie; Weber, Torsten

2017-12-01

We present the latest developments to the CheckMATE program that allows models of new physics to be easily tested against the recent LHC data. To achieve this goal, the core of CheckMATE now contains over 60 LHC analyses of which 12 are from the 13 TeV run. The main new feature is that CheckMATE 2 now integrates the Monte Carlo event generation via MadGraph5_aMC@NLO and Pythia 8. This allows users to go directly from a SLHA file or UFO model to the result of whether a model is allowed or not. In addition, the integration of the event generation leads to a significant increase in the speed of the program. Many other improvements have also been made, including the possibility to now combine signal regions to give a total likelihood for a model.

Evaluation of a social skills program based on social learning theory, implemented in a school setting.

PubMed

Sheridan, Beth A; MacDonald, Douglas A; Donlon, Mark; Kuhn, Beth; McGovern, Katie; Friedman, Harris

2011-04-01

Using a sample of 647 Canadian children in kindergarten to Grade 3 (325 boys, 322 girls), the present study evaluated the perceived effectiveness of Skillstreaming (McGinnis & Goldstein, 2003), a widely known social skills program implemented to target the development of four skill sets, i.e., listening, following directions, problem-solving, and knowing when to tell. Results indicated significant postprogram improvements in all skills as well as in ratings of overall prosociality obtained from both classroom teachers and mental health staff, with medium to large effect sizes obtained from teachers' and mental health professionals' ratings, respectively. Additional analyses yielded significant but weak moderator effects of grade and preprogram prosocial functioning for teacher ratings but no consistent moderator effects for children's sex or school location (i.e., urban versus rural) regardless of rater.

Millimeter Wave Filter Design with Suspended Stripline

DTIC Science & Technology

1989-09-01

VARIATIONAL CALCULATION METHOD.....................44 B. ALTERNATE ASSUMPTION FOR CHARGE DISTRIBUTION....... 47 APPE’NDIX B. FORTRAN PROGRAM...negative) of K. Instead of equation (99) the K was chosen such as to maximize the line capacitance C (in this case K = 3). B. ALTERNATE ASSUMPTION FOR...REAL Gl,G2,G3,HH1,T,KQ,56,C1M,C2M,C3M,C4M,NCAPM, CAPM REAL ClEC2E,C3E,C4E,NCAPE,CAPE,CO INTEGER IMAX,MMAXNMAX,JMAX, I,J,Nl,N2,M2,M,N,I2,J2,I3,J3,L

Astronaut James A. McDivitt has blood pressure checked during preflight exam.

NASA Technical Reports Server (NTRS)

1965-01-01

S65-19524 (1 June 1965) --- Dr. Charles A. Berry, Chief of Center Medical Programs, Manned Spacecraft Center (MSC), Houston, prepares to check the blood pressure of astronaut James A. McDivitt, command pilot for the Gemini-Titan 4 space flight. McDivitt is on the tilt table at the Aero Medical Area, Merritt Island, where he and Astronaut Edward H. White II, GT-4 pilot, underwent pre-flight physicals in preparation for the 4-day, 62 revolution space flight. The two astronauts were declared in top physical condition. In the background is Dr. Gordon Benson, NASA physician at Cape Kennedy.

ASK Talks with Alex McCool

NASA Technical Reports Server (NTRS)

2003-01-01

As a charter member at Marshall, McCool was instrumental in the design of the propulsion systems for the Saturn launch vehicles that propelled Apollo to the Moon and directed project engineering for Skylab, the first space science laboratory. Alex McCool's 48-year career includes exceptional contributions to the vehicles that launched America into orbit and carried human beings to the moon. Presently, he is the manager of the Space Shuttle Projects Office at Marshall. Among his many honors he recently received the National Space Club's 2002 Astronautics Engineer Award. The award recognizes those who have made outstanding contributions in engineering management to the national space program.

Stockpile Stewardship's 20th Anniversary

ScienceCinema

Hecker, Siegfried; Gottemoeller, Rose; Reis, Victor H.; McMillan, Charles; Rohlfing, Joan; Hurricane, Omar; Hagengruber, Roger; Taylor, John

2018-06-22

A short oral history of the NNSA's Stockpile Stewardship Program, produced in association with the 20th anniversary of the program. It features Siegfried Hecker, Rose Gottemoeller, Victor Reis, Charles McMillan, Joan Rohlfing, Omar Hurricane, Roger Hagengruber, and John Taylor.

Lessons Learned from the Everglades Collaborative Adaptive Management Program

EPA Science Inventory

Recent technical papers explore whether adaptive management (AM) is useful for environmental management and restoration efforts and discuss the many challenges to overcome for successful implementation, especially for large-scale restoration programs (McLain and Lee 1996; Levine ...

Conference Committees: Conference Committees

NASA Astrophysics Data System (ADS)

2009-09-01

International Programm Committee (IPC) Harald Ade NCSU Sadao Aoki University Tsukuba David Attwood Lawrence Berkeley National Laboratory/CXRO Christian David Paul Scherrer Institut Peter Fischer Lawrence Berkeley National Laboratory Adam Hitchcock McMaster University Chris Jacobsen SUNY, Stony Brook Denis Joyeux Lab Charles Fabry de l'Institut d'Optique Yasushi Kagoshima University of Hyogo Hiroshi Kihara Kansai Medical University Janos Kirz SUNY Stony Brook Maya Kiskinova ELETTRA Ian McNulty Argonne National Lab/APS Alan Michette Kings College London Graeme Morrison Kings College London Keith Nugent University of Melbourne Zhu Peiping BSRF Institute of High Energy Physics Francois Polack Soleil Christoph Quitmann Paul Scherrer Institut Günther Schmahl University Göttingen Gerd Schneider Bessy Hyun-Joon Shin Pohang Accelerator Lab Jean Susini ESRF Mau-Tsu Tang NSRRC Tony Warwick Lawrence Berkeley Lab/ALS Local Organizing Committee Christoph Quitmann Chair, Scientific Program Charlotte Heer Secretary Christian David Scientific Program Frithjof Nolting Scientific Program Franz Pfeiffer Scientific Program Marco Stampanoni Scientific Program Robert Rudolph Sponsoring, Financials Alfred Waser Industry Exhibition Robert Keller Public Relation Markus Knecht Computing and WWW Annick Cavedon Proceedings and Excursions and Accompanying Persons Program Margrit Eichler Excursions and Accompanying Persons Program Kathy Eikenberry Excursions and Accompanying Persons Program Marlies Locher Excursions and Accompanying Persons Program

Improving the accuracy of electronic moisture meters for runner-type peanuts

USDA-ARS?s Scientific Manuscript database

Runner-type peanut kernel moisture content (MC) is measured periodically during curing and post harvest processing with electronic moisture meters for marketing and quality control. MC is predicted for 250 g samples of kernels with a mathematical function from measurements of various physical prope...

STS-92 Mission Specialist McArthur has his launch and entry suit adjusted

NASA Technical Reports Server (NTRS)

2000-01-01

In the Operations and Checkout Building, STS-92 Mission Specialist William S. McArthur Jr. has the gloves on his launch and entry suit adjusted during fit check. McArthur and the rest of the crew are at KSC for Terminal Countdown Demonstration Test activities. The TCDT provides emergency egress training, simulated countdown exercises and opportunities to inspect the mission payload. This mission will be McArthur's third Shuttle flight. STS-92 is scheduled to launch Oct. 5 at 9:38 p.m. EDT from Launch Pad 39A on the fifth flight to the International Space Station. It will carry two elements of the Space Station, the Integrated Truss Structure Z1 and the third Pressurized Mating Adapter. The mission is also the 100th flight in the Shuttle program.

STS-92 Mission Specialist McArthur has his launch and entry suit adjusted

NASA Technical Reports Server (NTRS)

2000-01-01

During pre-pack and fit check in the Operations and Checkout Building, STS-92 Mission Specialist William S. McArthur Jr. uses a laptop computer while garbed in his full launch and entry suit. McArthur and the rest of the crew are at KSC for Terminal Countdown Demonstration Test activities. The TCDT provides emergency egress training, simulated countdown exercises and opportunities to inspect the mission payload. This mission will be McArthur's third Shuttle flight. STS-92 is scheduled to launch Oct. 5 at 9:38 p.m. EDT from Launch Pad 39A on the fifth flight to the International Space Station. It will carry two elements of the Space Station, the Integrated Truss Structure Z1 and the third Pressurized Mating Adapter. The mission is also the 100th flight in the Shuttle program.

MITLL 2015 Language Recognition Evaluation System Description

DTIC Science & Technology

2016-01-27

912 8.18 qsl-rus Russian 2021 37.80 ara-ary Maghrebi 919 46.91 spa-car Carib. Spa. 194 30.59 ara-arz Egyptian 440 97.27 spa-eur Eur. Spa. 366 8.55...qsl-pol Polish 695 32.14 ara-arb MSA 912 8.18 qsl-rus Russian 2021 37.80 ara-ary Maghrebi 919 46.91 spa-car Carib. Spa. 194 30.59 ara-arz Egyptian ...BOTTLENECK I-VECTOR SYSTEM (BNF1) The Deep Neural Network architecture that we used for this system was composed of seven hidden layers. The sixth

Effect of vertical sleeve gastrectomy in melanocortin receptor 4-deficient rats.

PubMed

Mul, Joram D; Begg, Denovan P; Alsters, Suzanne I M; van Haaften, Gijs; Duran, Karen J; D'Alessio, David A; le Roux, Carel W; Woods, Stephen C; Sandoval, Darleen A; Blakemore, Alexandra I F; Cuppen, Edwin; van Haelst, Mieke M; Seeley, Randy J

2012-07-01

Bariatric surgery is currently the most effective treatment for obesity. Vertical sleeve gastrectomy (VSG), a commonly applied bariatric procedure, involves surgically incising most of the volume of the stomach. In humans, partial loss of melanocortin receptor-4 (MC4R) activity is the most common monogenic correlate of obesity regardless of lifestyle. At present it is unclear whether genetic alteration of MC4R signaling modulates the beneficial effects of VSG. Following VSG, we analyzed body weight, food intake, glucose sensitivity, and macronutrient preference of wild-type and MC4R-deficient (Mc4r(+/-) and Mc4r(-/-)) rats compared with sham-operated controls. VSG reduced body weight and fat mass and improved glucose metabolism and also shifted preference toward carbohydrates and away from fat. All of this occurred independently of MC4R activity. In addition, MC4R was resequenced in 46 human subjects who underwent VSG. We observed common genetic variations in the coding sequence of MC4R in five subjects. However, none of those variations appeared to affect the outcome of VSG. Taken together, these data suggest that the beneficial effect of VSG on body weight and glucose metabolism is not mediated by alterations in MC4R activity.

Effect of vertical sleeve gastrectomy in melanocortin receptor 4-deficient rats

PubMed Central

Mul, Joram D.; Begg, Denovan P.; Alsters, Suzanne I. M.; van Haaften, Gijs; Duran, Karen J.; D'Alessio, David A.; le Roux, Carel W.; Woods, Stephen C.; Sandoval, Darleen A.; Blakemore, Alexandra I. F.; Cuppen, Edwin; van Haelst, Mieke M.

2012-01-01

Bariatric surgery is currently the most effective treatment for obesity. Vertical sleeve gastrectomy (VSG), a commonly applied bariatric procedure, involves surgically incising most of the volume of the stomach. In humans, partial loss of melanocortin receptor-4 (MC4R) activity is the most common monogenic correlate of obesity regardless of lifestyle. At present it is unclear whether genetic alteration of MC4R signaling modulates the beneficial effects of VSG. Following VSG, we analyzed body weight, food intake, glucose sensitivity, and macronutrient preference of wild-type and MC4R-deficient (Mc4r+/− and Mc4r−/−) rats compared with sham-operated controls. VSG reduced body weight and fat mass and improved glucose metabolism and also shifted preference toward carbohydrates and away from fat. All of this occurred independently of MC4R activity. In addition, MC4R was resequenced in 46 human subjects who underwent VSG. We observed common genetic variations in the coding sequence of MC4R in five subjects. However, none of those variations appeared to affect the outcome of VSG. Taken together, these data suggest that the beneficial effect of VSG on body weight and glucose metabolism is not mediated by alterations in MC4R activity. PMID:22535749

Winglets for the Airlines

NASA Technical Reports Server (NTRS)

1994-01-01

Originally developed as part of the Aircraft Energy Efficiency Program in the 1970's, winglets are now used by long-ranging aircraft as well as business jets and smaller planes. The winglet is an upturned wingtip, a lifting surface designed to operate in the wingtip "vortex," a whirlpool of air at an airplane's wingtips. It takes advantage of the turbulent vortex flow by producing forward thrust. This reduces drag and improves fuel efficiency. After McDonnell Douglas conducted wind tunnel tests of winglets in 1978-79, the technology was incorporated into the MD-11, their large payload, long range airplane. There are now more than 100 MD-11s in service.

Solar-Terrestrial Interactions

DTIC Science & Technology

2008-01-01

PROGRAM ELEMENT NUMBER 0601102F 6. AUTHOR(S) Stephen W. Kahler 5d. PROJECT NUMBER 5e. TASK NUMBER 2311G4 (PL012) 5f. WORK UNIT NUMBER 7...the three principal mechanisms: axial, equinoctial , and Russell-McPherron. During 1954 and 1996, the axial and Russell-McPherron effects were...long run (decades to centuries) of geomagnetic activity where the six-month wave is primarily (~70%) due to the equinoctial hypothesis. 4

Detection And Classification Of Web Robots With Honeypots

DTIC Science & Technology

2016-03-01

CLASSIFICATION OF WEB ROBOTS WITH HONEYPOTS by Sean F. McKenna March 2016 Thesis Advisor: Neil Rowe Second Reader: Justin P. Rohrer THIS...Master’s thesis 4. TITLE AND SUBTITLE DETECTION AND CLASSIFICATION OF WEB ROBOTS WITH HONEYPOTS 5. FUNDING NUMBERS 6. AUTHOR(S) Sean F. McKenna 7...DISTRIBUTION CODE 13. ABSTRACT (maximum 200 words) Web robots are automated programs that systematically browse the Web , collecting information. Although

House Hearing Nunn-McCurdy Review of NPOESS

NASA Image and Video Library

2006-06-07

NASA Administrator Michael Griffin, left, testifies before the House Committee on Science and Technology regarding the future of the National Polar-orbiting Operational Environmental Satellite System (NPOESS) and results of the Nunn-McCurdy review of NOAA’s weather satellite program, as Under Secretary of the Air Force Dr. Ronald Sega looks on, Thursday, June 8, 2006, at the Rayburn House Office Building in Washington. Photo Credit: (NASA/Bill Ingalls)

Mobile CubeSat Command and Control (MC3)

DTIC Science & Technology

2011-09-01

at NPS and other universities. A. MC3 OVERVIEW 1. Colony Program The National Reconnaissance Office (NRO) has, over the past couple of years... Pumpkin Incorporated and has contracted for the Colony II bus through Boeing. These contracts have different bus requirements, but enable...it is important to maintain a good relationship between NRL and NPS to effectively leverage the work NRL has done in the past on these small ground