Women's health

MedlinePlus

... 9th ed. Philadelphia, PA: Elsevier; 2016:chap 25. Review Date 4/5/2016 Updated by: Irina Burd, ... Johns Hopkins University School of Medicine, Baltimore, MD. Review provided by VeriMed Healthcare Network. Also reviewed by ...

Bowel retraining

MedlinePlus

... ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 136. Review Date 7/22/2016 Updated by: Subodh K. Lal, MD, gastroenterologist with Gastrointestinal Specialists of Georgia, Austell, GA. Review provided by VeriMed Healthcare Network. Also reviewed by ...

77 FR 56661 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-13

... Emphasis Panel; Member Conflict: Neurodevelopment, Plasticity, and Regeneration. Date: October 9, 2012... Bone, Function, Metabolism and Regeneration. Date: October 9, 2012. Time: 1:30 p.m. to 4 p.m. Agenda..., Bethesda, MD 20892, 301-435-1212, [email protected] . Name of Committee: Cell Biology Integrated Review...

77 FR 25487 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-30

... (Virtual Meeting). Contact Person: Ai-Ping Zou, MD, Ph.D., Scientific Review Officer, Center for Scientific... Scientific Review Special Emphasis Panel; Cancer Therapeutics AREA Grant Applications. Date: May 24, 2012...

75 FR 27708 - National Institute of Standards and Technology Performance Review Board Membership

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-18

... Neutron Research, National Institute of Standards & Technology, Gaithersburg, MD 20899. Appointment..., Building and Fire Research Laboratory, National Institute of Standards & Technology, Gaithersburg, MD 20899. Appointment Expires: 12/31/10. Dated: May 11, 2010. Katharine Gebbie, Director, Physics Laboratory. [FR Doc...

Pinworms

MedlinePlus

... still be around. How Do I Keep Pinworms Away? The best way to keep from getting pinworms ... these simple steps, you can keep the worms away! Reviewed by: Joanne Murren-Boezem, MD Date reviewed: ...

78 FR 24223 - National Institute of Biomedical Imaging and Bioengineering; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-24

... Imaging and Bioengineering Special Emphasis Panel; Center for Multiscale Simulations in the Human..., Bethesda, MD 20892, (Virtual Meeting). Contact Person: John K. Hayes, Ph.D., Scientific Review Officer... Boulevard, Room 959, Bethesda, MD 20892, 301-451-3398, [email protected] . Dated: April 18, 2013. David...

78 FR 6126 - National Institute of Biomedical Imaging and Bioengineering; Notice of Closed Meeting.

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-29

... Institutes of Health, Two Democracy Plaza, Suite 920, 6707 Democracy Boulevard, Bethesda, MD 20892, (Telephone Conference Call). Contact Person: Ruixia Zhou, Ph.D., Scientific Review Officer, 6707 Democracy Boulevard, Democracy Two Building, Suite 957, Bethesda, MD 20892, 301-496-4773, [email protected] . Dated...

Pierced Ears

MedlinePlus

... weeks. Then you can start enjoying your pierced ears again! Reviewed by: Steven Dowshen, MD Date reviewed: September ... All information on KidsHealth® is for educational purposes only. For specific medical advice, diagnoses, and treatment, ...

Blepharoplasty - slideshow

MedlinePlus

... or eliminate dark circles under the eyes. Review Date 1/10/2017 Updated by: David A. Lickstein, MD, FACS, specializing in cosmetic and reconstructive plastic surgery, Palm Beach Gardens, FL. Review provided by VeriMed Healthcare ...

75 FR 1793 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-13

...; Social Psychology, Personality and Interpersonal Processes Study Section. Date: February 4-5, 2010. Time..., MD 20892 (Virtual Meeting). Contact: Bob Weller, PhD, Scientific Review Officer, Center for...

Nose surgery - slideshow

MedlinePlus

... the size and shape of the nose. Review Date 1/10/2017 Updated by: David A. Lickstein, MD, FACS, specializing in cosmetic and reconstructive plastic surgery, Palm Beach Gardens, FL. Review provided by VeriMed Healthcare ...

Forehead lift - slideshow

MedlinePlus

... can be reduced through a forehead lift. Review Date 11/20/2017 Updated by: David A. Lickstein, MD, FACS, specializing in cosmetic and reconstructive plastic surgery, Palm Beach Gardens, FL. Review provided by VeriMed Healthcare ...

78 FR 54665 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-05

...: Center for Scientific Review Special Emphasis Panel; Basic Biology of Neurological Disorders. Date..., Bethesda, MD 20892, 301-435- 1242, [email protected] . Name of Committee: Biological Chemistry and...

Dermatomyositis

MedlinePlus

... Web site. rarediseases.org/rare-diseases/dermatomyositis/ . Accessed March 7, 2017. Review Date 2/8/2017 Updated by: Gordon A. Starkebaum, MD, Professor of Medicine, Division of Rheumatology, University of Washington School of Medicine, Seattle, WA. Also reviewed by ...

Breast lift (mastopexy) - slideshow

MedlinePlus

... routine breast exam are required before surgery. Review Date 1/10/2017 Updated by: David A. Lickstein, MD, FACS, specializing in cosmetic and reconstructive plastic surgery, Palm Beach Gardens, FL. Review provided by VeriMed Healthcare ...

Umbilical hernia repair - slideshow

MedlinePlus

... during development penetrate the fetal abdominal wall. Review Date 1/10/2017 Updated by: David A. Lickstein, MD, FACS, specializing in cosmetic and reconstructive plastic surgery, Palm Beach Gardens, FL. Review provided by VeriMed Healthcare ...

Household Safety: Preventing Choking

MedlinePlus

... More for Teens Teens site Sitio para adolescentes Body Mind Sexual Health Food & Fitness Diseases & Conditions Infections Drugs & ... exploring are the activities that develop your child's body and mind. Reviewed by: Rupal Christine Gupta, MD Date reviewed: ...

77 FR 31624 - National Institute of Biomedical Imaging and Bioengineering; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-29

... Institutes of Health, Two Democracy Plaza, 6707 Democracy Boulevard, Rm. 951, Bethesda, MD 20892, (Telephone Conference Call). Contact Person: Ruixia Zhou, Ph.D., Scientific Review Officer, 6707 Democracy Boulevard, Democracy Two Building, Suite 957, Bethesda, MD 20892, 301-496-4773, [email protected] . Dated: May 21...

77 FR 512 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-05

..., Bethesda, MD 20892, (301) 435- 1198, [email protected] . Name of Committee: Oncology 2--Translational Clinical Integrated Review Group, Clinical Oncology Study Section. Date: February 6-7, 2012. Time: 8 a.m...

Working during cancer treatment

MedlinePlus

... cancer treatment. www.cancer.gov/publications/patient-education/life-after-treatment.pdf . Updated May 2014. Accessed October 12, 2016. Review Date 8/15/2016 Updated by: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review ...

Adult Still's disease

MedlinePlus

... org/rare-diseases/adult-onset-stills-disease/ . Accessed March 14, 2017. Review Date 2/8/2017 Updated by: Gordon A. Starkebaum, MD, Professor of Medicine, Division of Rheumatology, University of Washington School of Medicine, Seattle, WA. Also reviewed by ...

Abdominoplasty - slideshow

MedlinePlus

... in the belly. In abdominoplasty, some of the fat is removed. Review Date 1/31/2017 Updated by: Mary C. Mancini, MD, PhD, Department of Surgery, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA. Review provided by VeriMed ...

Juvenile Idiopathic Arthritis

MedlinePlus

... condition so that it has the least possible impact on your life. Reviewed by: AnneMarie C. Brescia, MD Date reviewed: ... site. Note: All information on TeensHealth® is for educational purposes only. For specific medical advice, diagnoses, and ...

Household Safety: Preventing Poisoning (For Parents)

MedlinePlus

... More for Teens Teens site Sitio para adolescentes Body Mind Sexual Health Food & Fitness Diseases & Conditions Infections Drugs & ... exploring are the activities that develop your child's body and mind. Reviewed by: Rupal Christine Gupta, MD Date reviewed: ...

75 FR 67379 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-02

...: Weight Loss, Obesity and Physical Activity. Date: November 15, 2010. Time: 10 a.m. to 11:30 a.m. Agenda..., Bethesda, MD 20892 (Telephone Conference Call). Contact Person: Lee S. Mann, PhD, Scientific Review Officer... Research Transition (A-START) in Drug Abuse and HIV/AIDS. Date: November 29, 2010. Time: 11 a.m. to 4 p.m...

76 FR 51379 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-18

... Drive, Bethesda, MD 20892, (Virtual Meeting). Contact Person: John Bleasdale, PhD, Scientific Review.... Contact Person: Reed A Graves, PhD, Scientific Review Officer, Center for Scientific Review, National... Group Biochemistry and Biophysics of Membranes Study Section. Date: September 26-27, 2011. Time: 8 a.m...

78 FR 50065 - National Cancer Institute; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-16

... Methodological Research for Cancer Epidemiology Cohorts. Date: October 25, 2013. Time: 10:30 a.m. to 2:30 p.m... Lopaczynski, MD, Ph.D., Scientific Review Officer, Research Programs Review Branch, Division of Extramural.... Contact Person: Shakeel Ahmad, Ph.D., Scientific Review Officer, Research Programs Review Branch, Division...

78 FR 8155 - National Cancer Institute; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-05

...; NCI Omnibus Cancer Biology 1. Date: March 11-12, 2013. Time: 8:00 a.m. to 5:00 p.m. Agenda: To review..., Special Review and Logistics Branch, Division of Extramural Activities, National Cancer Institute, NIH..., MD, Scientific Review Officer, Research Programs Review Branch, Division of Extramural Activities...

77 FR 33474 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-06

... Translational Integrated Review Group; Cancer Molecular Pathobiology Study Section. Date: June 25-26, 2012. Time... 7818, Bethesda, MD 20892, 301-435- 1198, [email protected] . Name of Committee: Molecular, Cellular and Developmental Neuroscience Integrated Review Group; Cellular and Molecular Biology of...

77 FR 31030 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-24

... Review Group; Cellular, Molecular and Integrative Reproduction Study Section. Date: June 21, 2012. Time...: Endocrinology, Metabolism, Nutrition and Reproductive Sciences Integrated Review Group; Molecular and Cellular..., Bethesda, MD 20892, 301-827- 7915, [email protected] . Name of Committee: Molecular, Cellular and...

Pelvic Inflammatory Disease (For Parents)

MedlinePlus

... about sexual health issues. Community health organizations and sexual counseling centers in your local area also may be able to offer some guidance. Reviewed by: Larissa Hirsch, MD Date reviewed: January ... Teens Sexual Development About Abstinence About Birth Control: What Parents ...

Constipation

MedlinePlus

... Stanton BF, St. Geme JW, Schor NF, eds. Nelson Textbook of Pediatrics. 20th ed. Philadelphia, PA: Elsevier; 2016:chap 306. Review Date 7/22/2016 Updated by: Subodh K. Lal, MD, gastroenterologist at Gastrointestinal Specialists of Georgia, Austell, GA. Review provided by VeriMed ...

77 FR 65567 - Center for Scientific Review; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-29

...: Risk, Prevention and Health Behavior Date: November 2, 2012. Time: 10:00 p.m. to 12:00 p.m. Agenda: To..., Bethesda, MD 20892, (Telephone Conference Call). Contact Person: Lee S Mann, Ph.D., Scientific Review...

5-HIAA

MedlinePlus

... and the carcinoid syndrome. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine . 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 232. Review Date 8/15/2016 Updated by: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by ...

Porphyria

MedlinePlus

... Hift RJ. The porphyrias. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine . 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 210. Review Date 2/1/2017 Updated by: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by ...

Pancreatitis - discharge

MedlinePlus

... Diet - clear liquid Diet - full liquid Enteral nutrition - child - managing problems Gallstones - discharge Gastrostomy feeding tube - bolus Jejunostomy feeding tube Review Date 12/1/2016 Updated by: Subodh K. Lal, MD, Gastroenterologist ...

Disseminated intravascular coagulation (DIC)

MedlinePlus

... and vitamin K deficiency. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine . 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 175. Review Date 10/21/2017 Updated by: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by ...

Serum globulin electrophoresis

MedlinePlus

... SV. Plasma cell disorders. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine . 25th ed. Philadelphia, PA: Elsevier Saunders; 2015:chap 187. Review Date 2/11/2016 Updated by: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by ...

78 FR 25754 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-02

..., Bethesda, MD 20892, (301) 435-1727, [email protected] . Name of Committee: Genes, Genomes, and Genetics Integrated Review Group; Molecular Genetics B Study Section. Date: May 29-30, 2013. Time: 7:00 p.m. to 6:30 p...

Klinefelter Syndrome (For Teens)

MedlinePlus

... classes go more smoothly. Reviewed by: Judith L. Ross, MD Date reviewed: September 2017 More on this topic for: Teens Delayed Puberty How Can I Improve My Self-Esteem? A Guy's Guide to Body Image When Will I Start Developing? The Basics on Genes and ...

Cosleeping and Your Baby

MedlinePlus

... another bedroom, it's best to wait until their child is at least 6 months of age. Reviewed by: Mary L. Gavin, MD Date reviewed: December 2016 More on this topic for: Parents Sudden Infant Death Syndrome (SIDS) All About Sleep Sleep and Your 1- ...

Pyloric Stenosis (For Parents)

MedlinePlus

... poops) over a period of 1 or 2 days show signs of dehydration, such as more than 4 to 6 hours between wet diapers, a sunken "soft spot" on the head, or sunken eyes Reviewed by: J. Fernando del Rosario, MD Date reviewed: March 2017 ...

78 FR 52206 - Center For Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-22

...: Biophysics, Biochemistry and Chemistry. Date: September 18-19, 2013. Time: 8:00 a.m. to 3:00 p.m. Agenda: To..., Bethesda, MD 20892 (Virtual Meeting). Contact Person: John L Bowers, Ph.D., Scientific Review Officer..., Ph.D., Scientific Review Officer, Center for Scientific Review, National Institutes of Health, 6701...

78 FR 31951 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-28

..., Bethesda, MD 20892, (Virtual Meeting). Contact Person: Nuria E Assa-Munt, Ph.D., Scientific Review Officer...; Small Business: Education, Psychology, and Biology in Health Behavior. Date: June 24-25, 2013. Time: 8..., (Virtual Meeting). Contact Person: David R Filpula, Ph.D., Scientific Review Officer, Center for Scientific...

75 FR 54156 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-03

... personal privacy. Name of Committee: Oncology 2--Translational Clinical Integrated Review Group, Basic... 3211, MSC 7808, Bethesda, MD 20892, 301-435- 0903, [email protected] . Name of Committee: Oncology 2--Translational Clinical Integrated Review Group, Clinical Oncology Study Section. Date: October 11-12, 2010. Time...

76 FR 81953 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-29

... Person: John Firrell, Ph.D., Scientific Review Officer, Center for Scientific Review, National Institutes...: Biological Chemistry and Macromolecular Biophysics. Date: January 19-20, 2012. Time: 11 a.m. to 10 p.m... Drive, Bethesda, MD 20892 (Virtual Meeting). Contact Person: Donald L. Schneider, Ph.D., Scientific...

77 FR 2738 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-19

..., Review Group; Clinical Molecular Imaging and Probe Development. Date: February 2-3, 2012. Time: 7 p.m. to..., Bethesda, MD 20892, (301) 435-1777, [email protected] . Name of Committee: Molecular, Cellular and...: Molecular, Cellular and Developmental Neuroscience Integrated Review Group; Cellular and Molecular Biology...

77 FR 4049 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-26

... Translational Integrated Review Group, Cancer Genetics Study Section. Date: February 23-24, 2012. Time: 8 a.m... 7892, Bethesda, MD 20892, (301) 402- 6297, [email protected] . Name of Committee: Molecular, [email protected] . Name of Committee: Genes, Genomes, and Genetics Integrated Review Group, Genetics of...

76 FR 27652 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-12

... Integrated Review Group, Molecular Genetics C Study Section. Date: June 23-24, 2011. Time: 8 a.m. to 6 p.m... . Name of Committee: Interdisciplinary Molecular Sciences and Training Integrated Review Group, Enabling..., Bethesda, MD 20892, (301) 435-1782, [email protected] . Name of Committee: Molecular, Cellular and...

75 FR 11895 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-12

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... and Social Stress. Date: March 24, 2010. Time: 2 p.m. to 3 p.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892 (Telephone...

76 FR 35900 - Center For Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-20

...: Child Psychopathology and Developmental Disabilities. Date: July 5, 2011. Time: 1 p.m. to 3:30 p.m... Drive, Bethesda, MD 20892, (Telephone Conference Call). Contact Person: Melissa Gerald, PhD, Scientific Review Officer, Center for Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Room...

75 FR 65020 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-21

...: Psychopathology, Developmental Disabilities, Stress and Aging. Date: November 12, 2010. Time: 8 a.m. to 5 p.m... Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Room 3182, MSC 7759, Bethesda, MD..., Center for Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Room 5208, MSC 7852...

Gallstones

MedlinePlus

... ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 155. Jackson PG, Evans SRT. Biliary system. In: Townsend CM ... 65. Review Date 4/19/2017 Updated by: Michael M. Phillips, MD, Clinical Professor of Medicine, The ...

Blood in the Urine (Hematuria) (For Parents)

MedlinePlus

... weeks later, just to make sure the urine is free of red blood cells. Hematuria that only happens once won't ... up tests to make sure your child's urine is free of red blood cells. Reviewed by: Robert S. Mathias, MD Date reviewed: ...

Ear tag

MedlinePlus

... an ear tag or pit are: An inherited tendency to have this facial feature A genetic syndrome ... Elsevier Churchill Livingstone; 2016:chap 19. Review Date 4/24/2017 Updated by: Liora C Adler, MD, ...

Bilirubin - urine

MedlinePlus

... Direct bilirubin - urine Images Male urinary system References Berk PD, Korenblat KM. Approach to the patient with ... Review Date 5/21/2017 Updated by: Laura J. Martin, MD, MPH, ABIM Board Certified in Internal ...

Bee poison

MedlinePlus

... are also much more likely to sting than European bees. Where Found Bee, wasp, hornet, and yellow ... Philadelphia, PA: Elsevier; 2016:chap 72. Review Date 7/10/2017 Updated by: Jacob L. Heller, MD, ...

ALP - blood test

MedlinePlus

... Renal cell carcinoma Alternative Names Alkaline phosphatase References Berk PD, Korenblat KM. Approach to the patient with ... Review Date 5/21/2017 Updated by: Laura J. Martin, MD, MPH, ABIM Board Certified in Internal ...

ALP isoenzyme test

MedlinePlus

... Alkaline phosphatase isoenzyme test Images Blood test References Berk PD, Korenblat KM. Approach to the patient with ... Review Date 5/21/2017 Updated by: Laura J. Martin, MD, MPH, ABIM Board Certified in Internal ...

77 FR 22580 - Center for Scientific Review; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-16

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review...: Brain and Spinal Cord Injury. Date: April 30, 2012. Time: 3 p.m. to 5 p.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892...

77 FR 63844 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-17

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... Review, National Institutes of Health, 6701 Rockledge Drive, Room 3224, MSC 7808, Bethesda, MD 20892, 301...; Small Business: Oral, Dental and Craniofacial Sciences. Date: November 14-15, 2012. Time: 8:00 a.m. to 5...

75 FR 42452 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-21

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review...: Diabetes and Obesity. Date: August 12-13, 2010. Time: 1 p.m. to 5 p.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892, (Virtual Meeting...

Genital sores - male

MedlinePlus

... genitalia. In: Wein AJ, Kavoussi LR, Partin AW, Peters CA, eds. Campbell-Walsh Urology . 11th ed. Philadelphia, ... 26042815 . Review Date 8/26/2017 Updated by: Peter J Chen, MD, FACOG, Associate Professor of OBGYN ...

77 FR 52751 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-30

... personal privacy. Name of Committee: Molecular, Cellular and Developmental Neuroscience Integrated Review Group, Molecular Neuropharmacology and Signaling Study Section. Date: September 24-25, 2012. Time: 8 a.m... 7770, Bethesda, MD 20892, (301) 435- 0684, [email protected] . Name of Committee: Molecular, Cellular...

76 FR 62079 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-06

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review..., Room 4222, MSC 7812, Bethesda, MD 20892, 301-435-2365, [email protected] . Name of Committee... Effects of Second Generation Psychotropic Medications Leading to Obesity and Diabetes. Date: October 27...

Eardrum repair - slideshow

MedlinePlus

... which connect the tympanic membrane to the inner ear. Review Date 11/15/2017 Updated by: Tang Ho, MD, Assistant Professor, Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology – Head and Neck Surgery, The ...

Gastrectomy - slideshow

MedlinePlus

... the small intestine, and functions to break up food into small particles that can be absorbed by the small intestine. Review Date 11/10/2016 Updated by: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. ...

Immunofixation - blood

MedlinePlus

... MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods . 23rd ed. St Louis, MO: Elsevier; 2017:chap 44. Review Date 5/20/2016 Updated by: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. ...

75 FR 55805 - National Institute of General Medical Sciences; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-14

... General Medical Sciences; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory... Sciences Initial Review Group, Biomedical Research and Research Training Review Subcommittee A. Date... General Medical Sciences, National Institutes of Health, Natcher Building, Room 3AN18, Bethesda, MD 20892...

78 FR 28599 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-15

... 20892, (301) 402-4411, [email protected] . Name of Committee: Oncology 2--Translational Clinical..., Bethesda, MD 20892, (301) 408-9724, [email protected] . Name of Committee: Oncology 2--Translational Clinical Integrated Review Group, Clinical Oncology Study Section. Date: June 10, 2013. Time: 8:00 a.m. to...

78 FR 51735 - Center For Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-21

...: Biological Chemistry and Macromolecular Biophysics. Date: August 26, 2013. Time: 11:00 a.m. to 12:00 p.m... Drive, Bethesda, MD 20892 (Telephone Conference Call). Contact Person: Nitsa Rosenzweig, Ph.D... Conference Call). Contact Person: Aftab A Ansari, Ph.D., Scientific Review Officer, Center for Scientific...

75 FR 156 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-04

... personal privacy. Name of Committee: Biological Chemistry and Macromolecular Biophysics Integrated Review..., Bethesda, MD 20892. (301) 451-1323. [email protected] . Name of Committee: Biological Chemistry and... Chemistry and Macromolecular Biophysics. Date: January 28-29, 2010. Time: 11 a.m. to 10 p.m. Agenda: To...

77 FR 30021 - Center for Scientific Review Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-21

... personal privacy. Name of Committee: Molecular, Cellular and Developmental Neuroscience Integrated Review Group; Cellular and Molecular Biology of Glia Study Section. Date: June 14, 2012. Time: 8:00 a.m. to 7..., Bethesda, MD 20892, (301) 435- 4433, [email protected] . Name of Committee: Molecular, Cellular and...

77 FR 38074 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-26

... Emphasis Panel; Member Conflict: Biobehavioral Mechanisms of Emotion, Stress and Health. Date: July 18... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review..., National Institutes of Health, 6701 Rockledge Drive, Room 4120, MSC 7802, Bethesda, MD 20892, 301-806-7314...

75 FR 18512 - National Institute on Deafness and Other Communication Disorders; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-12

... Deafness and Other Communication Disorders Special Emphasis Panel, LRP's. Date: May 3, 2010. Time: 1 p.m..., 6120 Executive Blvd., Rockville, MD 20852. (Virtual Meeting.) Contact Person: Sheo Singh, PhD...'s Clinical Trial. Date: May 7, 2010. Time: 4 p.m. to 5 p.m. Agenda: To review and evaluate grant...

75 FR 75872 - Airworthiness Directives; McDonnell Douglas Corporation Model DC-9-30, DC-9-40, and DC-9-50...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-07

... reviewed Boeing Service Bulletins DC9-28-212 (for Model DC- 9-30, DC-9-40, and DC-9-50 series airplanes... on airplanes changed in accordance with Boeing Service Bulletin DC9-28-212 or MD90-28-010, both dated... accomplishing the modification). Boeing Service Bulletins DC9-28-212 and MD90-28-010, both Revision 1, both...

Hot tub folliculitis

MedlinePlus

... RG. Folliculitis. In: Lebwohl MG, Heymann WR, Berth-Jones J, Coulson I, eds. Treatment of Skin Disease: Comprehensive Therapeutic Strategies . 4th ed. Philadelphia, PA: Elsevier; 2014:chap 83. Review Date 10/24/2016 Updated by: David L. Swanson, MD, Vice Chair ...

Seborrheic keratosis

MedlinePlus

... Seborrheic kertosis. In: Lebwohl MG, Heymann WR, Berth-Jones J, Coulson I, eds. Treatment of Skin Disease: Comprehensive Therapeutic Strategies . 4th ed. Philadelphia, PA: Elsevier Saunders; 2014:chap 220. Review Date 10/24/2016 Updated by: David L. Swanson, MD, Vice Chair ...

Pityriasis rosea

MedlinePlus

... Pityriasis rosea. In: Lebwohl MG, Heymann WR, Berth-Jones J, Coulson I, eds. Treatment of Skin Disease: Comprehensive Therapeutic Strategies . 4th ed. Philadelphia, PA: Elsevier; 2014:chap 186. Review Date 12/10/2016 Updated by: Linda J. Vorvick, MD, Clinical Associate ...

77 FR 54919 - National Institute on Alcohol Abuse and Alcoholism; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-06

... Alcohol Abuse and Alcoholism; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory... Alcohol Abuse and Alcoholism Initial Review Group Biomedical Research Review Subcommittee. Date: October... Alcohol Abuse and Alcoholism, 5635 Fishers Lane, Rm 2019, Bethesda, MD 20892, 301-443-2861, marmillotp...

75 FR 49499 - Center for Scientific Review; Notice of Closed Meetings

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Prerenal azotemia

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Palliative care - what the final days are like

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Muscle dysmorphia: could it be classified as an addiction to body image?

PubMed

Foster, Andrew C; Shorter, Gillian W; Griffiths, Mark D

2015-03-01

Muscle dysmorphia (MD) describes a condition characterised by a misconstrued body image in which individuals who interpret their body size as both small or weak even though they may look normal or highly muscular.MD has been conceptualized as a type of body dysmorphic disorder, an eating disorder, and obsessive–compulsive disorder symptomatology. METHOD AND AIM: Through a review of the most salient literature on MD, this paper proposes an alternative classification of MD--the ‘Addiction to Body Image’ (ABI) model--using Griffiths (2005)addiction components model as the framework in which to define MD as an addiction. It is argued the addictive activity in MD is the maintaining of body image via a number of different activities such as bodybuilding, exercise,eating certain foods, taking specific drugs (e.g., anabolic steroids), shopping for certain foods, food supplements,and the use or purchase of physical exercise accessories). In the ABI model, the perception of the positive effects on the self-body image is accounted for as a critical aspect of the MD condition (rather than addiction to exercise or certain types of eating disorder). Based on empirical evidence to date, it is proposed that MD could be re-classified as an addiction due to the individual continuing to engage in maintenance behaviours that may cause long-term harm.

77 FR 6570 - National Institute of Neurological Disorders and Stroke; Notice of Closed Meetings

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2012-02-08

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Muscle dysmorphia: Could it be classified as an addiction to body image?

PubMed Central

FOSTER, ANDREW C.; SHORTER, GILLIAN W.

2015-01-01

Background Muscle dysmorphia (MD) describes a condition characterised by a misconstrued body image in which individuals who interpret their body size as both small or weak even though they may look normal or highly muscular. MD has been conceptualized as a type of body dysmorphic disorder, an eating disorder, and obsessive–compulsive disorder symptomatology. Method and aim Through a review of the most salient literature on MD, this paper proposes an alternative classification of MD – the ‘Addiction to Body Image’ (ABI) model – using Griffiths (2005) addiction components model as the framework in which to define MD as an addiction. Results It is argued the addictive activity in MD is the maintaining of body image via a number of different activities such as bodybuilding, exercise, eating certain foods, taking specific drugs (e.g., anabolic steroids), shopping for certain foods, food supplements, and the use or purchase of physical exercise accessories). In the ABI model, the perception of the positive effects on the self-body image is accounted for as a critical aspect of the MD condition (rather than addiction to exercise or certain types of eating disorder). Conclusions Based on empirical evidence to date, it is proposed that MD could be re-classified as an addiction due to the individual continuing to engage in maintenance behaviours that may cause long-term harm. PMID:25592218

76 FR 44572 - Plants for Planting Whose Importation Is Not Authorized Pending Pest Risk Analysis; Notice of...

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2011-07-26

... available to the public for review and comment. DATES: We will consider all comments that we receive on or... Development, PPD, APHIS, Station 3A-03.8, 4700 River Road Unit 118, Riverdale, MD 20737- 1238. The data sheets... importation of plants for planting (including living plants, plant parts, seeds, and plant cuttings) to...

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77 FR 42459 - Airworthiness Directives; MD Helicopters, Inc. (MDHI) Helicopters

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2012-07-19

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Clinical Investigation Program Report.

DTIC Science & Technology

1983-10-01

metastatic to liver. (0) H-83-63. Double-blind, randomized parallel comparison of two different dosage regimens of naproxen sodium in patients with...different dosage regimens of naproxen sodium in patients with bone pain due to m etastatic cancer. Start Date: May 83 Est Comp Date: Indefinite Principal...Investigator: Facility: LTC D Gandara, MD LAMC CPT R Mansour, MD D ept/Svc: Associate Investigators: Hematology-Oncology Key Words: naproxen sodium

78 FR 17996 - MCM Rail Services LLC-Petition for Retroactive Exemption-In Sparrows Point, Md.

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... LLC--Petition for Retroactive Exemption--In Sparrows Point, Md. AGENCY: Surface Transportation Board... of rail line in Sparrows Point, Md. (the Line). DATES: MCM's supplemental information is due by April... Railroad, and currently named the Baltimore Industrial Railway, is located at 1430 Sparrows Point Boulevard...

Novel Therapeutic Development of NF1-Associated Malignant Peripheral Nerve Sheath Tumor (MPNST)

DTIC Science & Technology

2016-08-01

peripheral nerve sheath tumor (MPSNT)”, 11/5/2015, SARC-CTOS (Connective Tissue Oncology Society) Symposium, Salt Lake City, Utah b) “PRC2 loss in...of malignant peripheral nerve sheath tumor (MPSNT)”, 11/5/2015, SARC-CTOS (Connective Tissue Oncology Society) Symposium, Salt Lake City, Utah 2...Medical Oncology Service FROM: Roger S Wilson, MD Chairman, Institutional Review Board/Privacy Board-A DATE: 02/11/2016 RE: Protocol # 16-052 Your

Cinnamon Bark, Water Soluble Cinnamon Extract, and Metformin as Initial Treatment for Type 2 Diabetes Mellitus: A Randomized, Controlled Trial

DTIC Science & Technology

2016-12-14

REPORT DOCUMENTATION PAGE Form ApprovedOMB No. 0704-0188 1 . REPORT DATE (DD-MM-YYYY) 2. REPORT TYPE 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER 6...estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the...Cinnamon Extract, and Metformin as Initial Treatment for Type 2 Diabetes Mellitus: A Randomized, Controlled Trial. Paul Crawford, MD Clinical Investigation

Back Schools for chronic non-specific low back pain.

PubMed

Parreira, Patrícia; Heymans, Martijn W; van Tulder, Maurits W; Esmail, Rosmin; Koes, Bart W; Poquet, Nolwenn; Lin, Chung-Wei Christine; Maher, Christopher G

2017-08-03

Many people with low back pain (LBP) become frequent users of healthcare services in their attempt to find treatments that minimise the severity of their symptoms. Back School consists of a therapeutic programme given to groups of people that includes both education and exercise. However, the content of Back School has changed over time and appears to vary widely today. This review is an update of a Cochrane review of randomised controlled trials (RCTs) evaluating the effectiveness of Back School. We split the Cochrane review into two reviews, one focusing on acute and subacute LBP, and one on chronic LBP. The objective of this systematic review was to determine the effect of Back School on pain and disability for adults with chronic non-specific LBP; we included adverse events as a secondary outcome. In trials that solely recruited workers, we also examined the effect on work status. We searched for trials in the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, CINAHL, two other databases and two trials registers to 15 November 2016. We also searched the reference lists of eligible papers and consulted experts in the field of LBP management to identify any potentially relevant studies we may have missed. We placed no limitations on language or date of publication. We included only RCTs and quasi-RCTs evaluating pain, disability, and/or work status as outcomes. The primary outcomes for this update were pain and disability, and the secondary outcomes were work status and adverse events. Two review authors independently performed the 'Risk of bias' assessment of the included studies using the 'Risk of bias' assessment tool recommended by The Cochrane Collaboration. We summarised the results for the short-, intermediate-, and long-term follow-ups. We evaluated the overall quality of evidence using the GRADE approach. For the outcome pain, at short-term follow-up, we found very low-quality evidence that Back School is more effective than no treatment (mean difference (MD) -6.10, 95% confidence interval (CI) -10.18 to -2.01). However, we found very low-quality evidence that there is no significant difference between Back School and no treatment at intermediate-term (MD -4.34, 95% CI -14.37 to 5.68) or long-term follow-up (MD -12.16, 95% CI -29.14 to 4.83). There was very low-quality evidence that Back School reduces pain at short-term follow-up compared to medical care (MD -10.16, 95% CI -19.11 to -1.22). Very low-quality evidence showed there to be no significant difference between Back School and medical care at intermediate-term (MD -9.65, 95% CI -22.46 to 3.15) or long-term follow-up (MD -5.71, 95% CI -20.27 to 8.84). We found very low-quality evidence that Back School is no more effective than passive physiotherapy at short-term (MD 1.96, 95% CI -9.51 to 13.43), intermediate-term (MD -16.89, 95% CI -66.56 to 32.79), or long-term follow-up (MD -12.86, 95% CI -61.22 to 35.50). There was very low-quality evidence that Back School is no better than exercise at short- term follow-up (MD -2.06, 95% CI -14.58 to 10.45). There was low-quality evidence that Back School is no better than exercise at intermediate-term (MD -4.46, 95% CI -19.44 to 10.52) and long-term follow-up (MD 4.58, 95% CI -0.20 to 9.36).For the outcome disability, we found very low-quality evidence that Back School is no more effective than no treatment at intermediate-term (MD -5.92, 95% CI -12.08 to 0.23) and long-term follow-up (MD -7.36, 95% CI -22.05 to 7.34); medical care at short-term (MD -1.19, 95% CI -7.02 to 4.64) and long-term follow-up (MD -0.40, 95% CI -7.33 to 6.53); passive physiotherapy at short-term (MD 2.57, 95% CI -15.88 to 21.01) and intermediate-term follow-up (MD 6.88, 95% CI -4.86 to 18.63); and exercise at short-term (MD -1.65, 95% CI -8.66 to 5.37), intermediate-term (MD 1.57, 95% CI -3.86 to 7.00), and long-term follow-up (MD 4.54, 95% CI -4.44 to 13.52). We found very low-quality evidence of a small difference between Back School and no treatment at short-term follow-up (MD -3.38, 95% CI -6.70 to -0.05) and medical care at intermediate-term follow-up (MD -6.34, 95% CI -10.89 to -1.79). Still, at long-term follow-up there was very low-quality evidence that passive physiotherapy is better than Back School (MD 9.60, 95% CI 3.65 to 15.54).Few studies measured adverse effects. The results were reported as means without standard deviations or group size was not reported. Due to this lack of information, we were unable to statistically pool the adverse events data. Work status was not reported. Due to the low- to very low-quality of the evidence for all treatment comparisons, outcomes, and follow-up periods investigated, it is uncertain if Back School is effective for chronic low back pain. Although the quality of the evidence was mostly very low, the results showed no difference or a trivial effect in favour of Back School. There are myriad potential variants on the Back School approach regarding the employment of different exercises and educational methods. While current evidence does not warrant their use, future variants on Back School may have different effects and will need to be studied in future RCTs and reviews.

75 FR 30296 - Special Local Regulation for Marine Event; Maryland Swim for Life, Chester River, Chestertown, MD

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-01

...-AA08 Special Local Regulation for Marine Event; Maryland Swim for Life, Chester River, Chestertown, MD... Chestertown, MD during the Maryland Swim for Life. Special local regulations are necessary to provide for the safety of life on navigable waters during the event. DATES: This rule is effective from 5:30 a.m. to 2:30...

78 FR 11896 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-20

... Rockledge Drive, Bethesda, MD 20892, (Virtual Meeting). Contact Person: Nancy Sheard, SCD, Scientific Review...: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892, (Virtual Meeting). Contact Person..., Bethesda, MD 20892, (Virtual Meeting). Contact Person: Heidi B Friedman, Ph.D., Scientific Review Officer...

77 FR 42713 - Notice of Intent to Grant an Exclusive License; PadJack, Inc.

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-20

... Security Agency Technology Transfer Program, 9800 Savage Road, Suite 6541, Fort George G. Meade, MD 20755... Savage Road, Suite 6541, Fort George G. Meade, MD 20755-6541, telephone (443) 479-9569. Dated: July 17...

Baltimore City Faith-Based Prostate Cancer Prevention and Control Coalition

DTIC Science & Technology

2007-02-01

University of Maryland Baltimore School of Medicine Baltimore MD 21201- 1082 REPORT DATE: February 2007 TYPE OF REPORT...Maryland Baltimore School of Medicine Baltimore MD 21201- 1082 9. SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR

The effect of adding metformin to insulin therapy for type 1 diabetes mellitus children: A systematic review and meta-analysis.

PubMed

Al Khalifah, Reem A; Alnhdi, Abdulrahman; Alghar, Hassan; Alanazi, Mohammad; Florez, Ivan D

2017-11-01

We aimed to assess the effectiveness of adding metformin to insulin in type 1 diabetes mellitus (T1DM) children for improving metabolic outcomes. We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) conducted on children age 6 to 19 years who are diagnosed with T1DM, and examined the effect of adding Metformin to standard insulin therapy. We performed literature searches on Ovid Midline, Ovid Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) from the date of inception of the database to February 15, 2016. Two reviewers screened titles and abstracts independently, assessed full text eligibility, and extracted information from eligible trials. The primary outcome is glycated hemoglobin (HbA1c), and the secondary outcomes are health-related quality of life, body mass index (BMI), lipid profile, total insulin daily dose, hypoglycaemia, and diabetes ketoacidosis. We screened 736 studies, and included 6 RCTs with 325 patients. All RCTs were of low risk of bias, and included adolescents (mean age 15 years). The meta-analysis showed that the addition of Metformin resulted in decreased total insulin daily dose (TIDD) (unit/kg/d) (mean difference [MD] = -0.15, 95%CI, -0.24, -0.06), and reduced BMI kg/m 2 (MD -1.46, 95%CI -2.54, 0.38), and BMI z-score (MD= - 0.11, 95%CI -0.21, -0.01), and similar HbA1c (%) (MD= - 0.05, 95%CI, -0.19, 0.29). The overall evidence quality was high to moderate. Current evidence does not support use of Metformin in T1DM adolescents to improve HbA1c. However, Metformin may provide modest reduction in TIDD and BMI. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

76 FR 50950 - Drawbridge Operation Regulation; Isle of Wight (Sinepuxent) Bay, Ocean City, MD

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-17

... position to accommodate heavy volumes of vehicular traffic due to the annual July 4th fireworks show. DATES... City, MD. The Ocean City July 4th fireworks show is an annual event and heavy volumes of vehicular...

Have Residents Produced More Research Since the Inception of the 80-Hour Workweek?

PubMed Central

Levy, David M.; Luchetti, Timothy J.; Levine, Brett R.

2017-01-01

Abstract Background This study hypothesizes that resident involvement in research has increased since institution of the maximum 80-hour workweek in 2002. Methods All 571 papers published in the Journal of Bone and Joint Surgery (JBJS) in 1997 and 2007 (five years before and after the start of the 80-hour workweek) were reviewed. To identify resident authors, a search was performed in the American Board of Orthopaedic Surgery (ABOS) database for any U.S. author with a medical doctorate (MD). Any authors who were board-certified more than two years after the publication date were identified as “residents.” Two-tailed Fisher’s exact tests were used to assess proportional changes over time. Results Between 1997 and 2007, the percentage of U.S. MD authors who were orthopaedic residents increased significantly from 12% to 18% (p = 0.01). U.S. publications with a resident first-author increased from 17% to 27% (p = 0.02), and contributions from foreign nations also increased significantly (p < 0.001). The number of total authors per paper increased (p < 0.001), but linear regression showed that this had no particular association with the proportion of residents (p = 0.20). The relative proportions of MD and non-MD authors did not change between years. The LOE of resident-authored papers improved significantly over time (p = 0.005), while that of international papers did not. Conclusions Proportional resident authorship has increased significantly in one of the highest-impact, peer-reviewed orthopaedic journals. LOE of resident-authored papers has improved, and basic science papers are more likely to have a resident first author. Level of Evidence: III, retrospective cohort study PMID:28852359

75 FR 79063 - Maryland Disaster #MD-00014

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-17

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12411 and 12412] Maryland Disaster MD-00014 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the State of Maryland dated 12/09/2010. Incident: Severe Storms and...

77 FR 72362 - National Institute of Neurological Disorders and Stroke; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-05

... Institutes of Health, Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852, (Telephone...: National Institutes of Health Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852..., Biological Basis Research in the Neurosciences, National Institutes of Health, HHS) Dated: November 28, 2012...

Neurobiological Underpinnings of Math and Reading Learning Disabilities

PubMed Central

Ashkenazi, Sarit; Black, Jessica M.; Abrams, Daniel A.; Hoeft, Fumiko; Menon, Vinod

2013-01-01

The primary goal of this review is to highlight current research and theories describing the neurobiological basis of math (MD), reading (RD), and comorbid math and reading disability (MD+RD). We first describe the unique brain and cognitive processes involved in acquisition of math and reading skills, emphasizing similarities and differences in each domain. Next we review functional imaging studies of MD and RD in children, integrating relevant theories from experimental psychology and cognitive neuroscience to characterize the functional neuroanatomy of cognitive dysfunction in MD and RD. We then review recent research on the anatomical correlates of MD and RD. Converging evidence from morphometry and tractography studies are presented to highlight distinct patterns of white matter pathways which are disrupted in MD and RD. Finally, we examine how the intersection of MD and RD provides a unique opportunity to clarify the unique and shared brain systems which adversely impact learning and skill acquisition in MD and RD, and point out important areas for future work on comorbid learning disabilities. PMID:23572008

Magnetic Resonance Imaging of Polymeric Drug Delivery Systems in Breast Cancer Solid Tumors

DTIC Science & Technology

2007-12-01

University of Maryland, Baltimore Baltimore, MD 21201- 1082 REPORT DATE: December 2007 TYPE OF REPORT: Annual Summary Addendum...Baltimore, MD 21201- 1082 9. SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM(S) U.S. Army Medical

75 FR 26993 - Alvin Darby, M.D.; Denial of Application

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-13

... DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 09-6] Alvin Darby, M.D.; Denial... Gretna, Louisiana. The Show Cause Order proposed the denial of Respondent's pending application for a DEA... attempts to serve Respondent were constitutionally adequate, the date when service was initially attempted...

Detail view of date stone marking the founding of the ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Detail view of date stone marking the founding of the Emmanuel Christian Community Church congregation - Reformed Episcopal Church of the Rock of Ages, 1210 West Lanvale Street, Baltimore, Independent City, MD

76 FR 75448 - Establishment of Class D and E Airspace; Frederick, MD

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-02

... and E airspace at Frederick, MD, to accommodate new Area Navigation (RNAV) Global Positioning System... enhances the safety and management of Instrument Flight Rules (IFR) operations for SIAPs at the airport. DATES: Effective 0901 UTC, February 9, 2012. The Director of the Federal Register approves this...

76 FR 21406 - Cynthia M. Cadet, M.D.; Decision and Order

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-15

... DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 10-34] Cynthia M. Cadet, M.D.; Decision and Order ACTION: Correction. On Thursday, April 7, 2011, the Drug Enforcement Administration... column. Dated: April 8, 2011. Michele M. Leonhart, Administrator. [FR Doc. 2011-9170 Filed 4-14-11; 8:45...

75 FR 27350 - National Institute of Mental Health; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-14

... Neuroscience Diversity Undergraduate Research Education Applications. Date: June 8, 2010. Time: 11 a.m. to 4 p..., Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852, (Telephone Conference Call) Contact Person... of Mental Health, NIH, Neuroscience Center, 6001 Executive Blvd., Room 6149, MSC 9608, Bethesda, MD...

76 FR 17141 - National Institute of Neurological Disorders and Stroke; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-28

..., Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852 (Telephone Conference Call). Contact Person..., NINDS/ NIH/DHHS/Neuroscience Center, 6001 Executive Boulevard, Suite 3208, MSC 9529, Bethesda, MD 20892....854, Biological Basis Research in the Neurosciences, National Institutes of Health, HHS) Dated: March...

75 FR 39548 - National Institute of Neurological Disorders and Stroke; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-09

..., Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852 (Telephone Conference Call). Contact Person... Research, NINDS/NIH/DHHS/Neuroscience Center, 6001 Executive Blvd., Suite 3208, Msc 9529, Bethesda, MD... Neurosciences, National Institutes of Health, HHS) Dated: July 1, 2010. Jennifer Spaeth, Director, Office of...

77 FR 19025 - National Institute of Neurological Disorders and Stroke; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-29

..., Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852, (Telephone Conference Call). Contact Person... Research, NINDS/NIH/DHHS/Neuroscience Center, 6001 Executive Blvd., Suite 3208, MSC 9529, Bethesda, MD... Neurosciences, National Institutes of Health, HHS) Dated: March 23, 2012. Jennifer S. Spaeth, Director, Office...

Microenvironment -Programmed Metastatic Prostate Cancer Stem Cells (mPCSCs)

DTIC Science & Technology

2016-10-01

accomplished all goals in Aims 1 and 2. Our lab recently relocated from the MD Anderson Cancer Center to Roswell Park Cancer Institute in Buffalo. We ...G. Tang, M.D., Ph.D. CONTRACTING ORGANIZATION: University of Texas MD Anderson Cancer Center Houston, TX 77030 REPORT DATE: October 2016 TYPE OF... Anderson Cancer Center Houston, TX 77030 9. SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM(S) U.S. Army Medical

Review of the fundamental theories behind small angle X-ray scattering, molecular dynamics simulations, and relevant integrated application.

PubMed

Boldon, Lauren; Laliberte, Fallon; Liu, Li

2015-01-01

In this paper, the fundamental concepts and equations necessary for performing small angle X-ray scattering (SAXS) experiments, molecular dynamics (MD) simulations, and MD-SAXS analyses were reviewed. Furthermore, several key biological and non-biological applications for SAXS, MD, and MD-SAXS are presented in this review; however, this article does not cover all possible applications. SAXS is an experimental technique used for the analysis of a wide variety of biological and non-biological structures. SAXS utilizes spherical averaging to produce one- or two-dimensional intensity profiles, from which structural data may be extracted. MD simulation is a computer simulation technique that is used to model complex biological and non-biological systems at the atomic level. MD simulations apply classical Newtonian mechanics' equations of motion to perform force calculations and to predict the theoretical physical properties of the system. This review presents several applications that highlight the ability of both SAXS and MD to study protein folding and function in addition to non-biological applications, such as the study of mechanical, electrical, and structural properties of non-biological nanoparticles. Lastly, the potential benefits of combining SAXS and MD simulations for the study of both biological and non-biological systems are demonstrated through the presentation of several examples that combine the two techniques.

76 FR 66075 - Center for Scientific Review Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-25

... applications. Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892, (Virtual Meeting..., Bethesda, MD 20892, (Virtual Meeting). Contact Person: Michael H. Chaitin, PhD, Scientific Review Officer... Health, 6701 Rockledge Drive, Bethesda, MD 20892, (Virtual Meeting). Contact Person: John C Pugh, PhD...

Neurology Falls. Patient Falls Risk Assessment, Neurology Clinic, Johns Hopkins Hospital, Baltimore, MD

DTIC Science & Technology

2009-07-06

currently valid ()MB control number. PLEASE DO NOT RETURN YOf IR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE (DD-MM-YYYY) 21 JUL 2008 2. REPORT TYPE Final...Hospital, Baltimore, MD 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR( S ) LT John M Gardner, MSC, USN 5d. PROJECT...NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME( S ) AND ADDRESS(ES) Johns Hopkins Hospital, Baltimore, MD Residency Site

78 FR 25259 - Notice of Intent To Grant an Exclusive License; Integrata Security, LLC

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-30

..., 9800 Savage Road, Suite 6848, Fort George G. Meade, MD 20755-6848. FOR FURTHER INFORMATION CONTACT: Marian T. Roche, Director, Technology Transfer Program, 9800 Savage Road, Suite 6848, Fort George G. Meade, MD 20755-6848, telephone (443) 634-3514. Dated: April 24, 2013. Aaron Siegel, Alternate OSD...

75 FR 41789 - Special Local Regulations for Marine Events; Patuxent River, Solomons, MD

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-19

...-AA08 Special Local Regulations for Marine Events; Patuxent River, Solomons, MD AGENCY: Coast Guard, DHS... proposed special local regulations for the ``Chesapeake Challenge'' power boat races, a marine event to be... proposal adds an additional date to the ``Chesapeake Challenge'' power boat racing on October 3, 2010...

76 FR 9225 - Drawbridge Operation Regulation; Curtis Creek, Baltimore, MD

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-17

...; Department of Homeland Security Delegation No. 0170.1. 0 2. From February 17, 2011 to November 30, 2011... of the Pennington Avenue Bridge, across Curtis Creek, mile 0.9, at Baltimore, MD. This temporary... replacement of the grid deck, floor beams and stringers. DATES: This temporary final rule is effective from 6...

Novel plasmid conferring kanamycin and tetracycline resistance in turkey-derived Campylobacter jejuni strain 11601MD

USDA-ARS?s Scientific Manuscript database

In Campylobacter spp., resistance to the antibiotics kanamycin and tetracycline is frequently associated with plasmid-borne genes. However, relatively few plasmids of Campylobacter jejuni have been fully characterized to date. A novel plasmid (p11601MD; 44,095 bp.) harboring tet(O) was identified in...

76 FR 80230 - Amendment of Class D and E Airspace; Baltimore, MD

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-23

... November 28, 2011, amending controlled airspace at Martin State Airport, Baltimore, MD. DATES: Effective... published a final rule in the Federal Register amending Class D and E airspace at Martin State Airport... the airspace designation for the Class D and Class E airspace areas at Martin State Airport, Baltimore...

Review of the fundamental theories behind small angle X-ray scattering, molecular dynamics simulations, and relevant integrated application

PubMed Central

Boldon, Lauren; Laliberte, Fallon; Liu, Li

2015-01-01

In this paper, the fundamental concepts and equations necessary for performing small angle X-ray scattering (SAXS) experiments, molecular dynamics (MD) simulations, and MD-SAXS analyses were reviewed. Furthermore, several key biological and non-biological applications for SAXS, MD, and MD-SAXS are presented in this review; however, this article does not cover all possible applications. SAXS is an experimental technique used for the analysis of a wide variety of biological and non-biological structures. SAXS utilizes spherical averaging to produce one- or two-dimensional intensity profiles, from which structural data may be extracted. MD simulation is a computer simulation technique that is used to model complex biological and non-biological systems at the atomic level. MD simulations apply classical Newtonian mechanics’ equations of motion to perform force calculations and to predict the theoretical physical properties of the system. This review presents several applications that highlight the ability of both SAXS and MD to study protein folding and function in addition to non-biological applications, such as the study of mechanical, electrical, and structural properties of non-biological nanoparticles. Lastly, the potential benefits of combining SAXS and MD simulations for the study of both biological and non-biological systems are demonstrated through the presentation of several examples that combine the two techniques. PMID:25721341

63. Photocopy of photograph, no date. MAP OF POTOMAC EDISON ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

63. Photocopy of photograph, no date. MAP OF POTOMAC EDISON COMPANY SYSTEM. (Courtesy of the Potomac Edison Company Library (Hagerstown, MD), Historical Data Files - Dam No. 5 Hydroelectric Plant, On Potomac River, Hedgesville, Berkeley County, WV

The effect of a beta-mannanase-based enzyme on growth performance and humoral immune response of broiler chickens fed diets containing graded levels of whole dates.

PubMed

Zangiabadi, Hamidreza; Torki, Mehran

2010-08-01

The use of low-quality whole dates in broilers' diets was evaluated. The apparent metabolizable energy (AMEn) of whole dates and date pits was determined with or without a beta-mannanase-based enzyme (Hemicell--a registered trademark of ChemGen Corp., Gaithersburg, MD. Dried Bacillus lentus fermentation solubles with 158 million units/kg minimum enzyme activity. Recommended usage rate is 0.4 g kg(-1) of feed. ChemGen Corp., Gaithersburg, MD, USA). A 3 x 2 factorial arrangement consisting of whole dates (0, 175, and 350 g kg(-1)) and enzyme (0 or 0.4 g kg(-1)) was performed to assess the effect of the enzyme on the nutritive value of whole dates (experiment 2) in broilers' diet. Enzyme improved AMEn contents of the whole dates and date pits. The diets containing 175 or 350 g kg(-1) whole dates produced body weight gain (BWG) similar to those obtained without dates. Enzyme improved BWG and feed conversion ratio throughout the experimental period. In conclusion, whole dates can be included in broiler diets at levels up to 350 g kg(-1). In addition, beta-mannanase supplementation would have beneficial effects on performance and immunity in birds fed on corn-soy or corn-soy-whole dates diets.

The Weather and Ménière's Disease: A Longitudinal Analysis in the UK.

PubMed

Schmidt, Wiebke; Sarran, Christophe; Ronan, Natalie; Barrett, George; Whinney, David J; Fleming, Lora E; Osborne, Nicholas J; Tyrrell, Jessica

2017-02-01

Changes in the weather influence symptom severity in Ménière's disease (MD). MD is an unpredictable condition that significantly impacts on quality of life. It is suggested that fluctuations in the weather, especially atmospheric pressure may influence the symptoms of MD. However, to date, limited research has investigated the impact of the weather on MD. In a longitudinal study, a mobile phone application collected data from 397 individuals (277 females and 120 males with an average age of 50 yr) from the UK reporting consultant-diagnosed MD. Daily symptoms (vertigo, aural fullness, tinnitus, hearing loss, and attack prevalence) and GPS locations were collected; these data were linked with Met Office weather data (including atmospheric pressure, humidity, temperature, visibility, and wind speed). Symptom severity and attack prevalence were reduced on days when atmospheric pressure was higher. When atmospheric pressure was below 1,013 hectopascals, the risk of an attack was 1.30 (95% confidence interval: 1.10, 1.54); when the humidity was above 90%, the risk of an attack was 1.26 (95% confidence interval 1.06, 1.49). This study provides the strongest evidence to date that changes in atmospheric pressure and humidity are associated with symptom exacerbation in MD. Improving our understanding of the role of weather and other environmental triggers in Ménière's may reduce the uncertainty associated with living with this condition, significantly contributing to improved quality of life.

The Weather and Ménière’s Disease: A Longitudinal Analysis in the UK

PubMed Central

Schmidt, Wiebke; Sarran, Christophe; Ronan, Natalie; Barrett, George; Whinney, David J.; Fleming, Lora E.; Osborne, Nicholas J.; Tyrrell, Jessica

2016-01-01

Hypothesis Changes in the weather influence symptom severity in Ménière’s disease (MD). Background MD is an unpredictable condition that significantly impacts on quality of life. It is suggested that fluctuations in the weather, especially atmospheric pressure may influence the symptoms of MD. However, to date, limited research has investigated the impact of the weather on MD. Methods In a longitudinal study, a mobile phone application collected data from 397 individuals (277 females and 120 males with an average age of 50 yr) from the UK reporting consultant-diagnosed MD. Daily symptoms (vertigo, aural fullness, tinnitus, hearing loss, and attack prevalence) and GPS locations were collected; these data were linked with Met Office weather data (including atmospheric pressure, humidity, temperature, visibility, and wind speed). Results Symptom severity and attack prevalence were reduced on days when atmospheric pressure was higher. When atmospheric pressure was below 1,013 hectopascals, the risk of an attack was 1.30 (95% confidence interval: 1.10, 1.54); when the humidity was above 90%, the risk of an attack was 1.26 (95% confidence interval 1.06, 1.49). Conclusion This study provides the strongest evidence to date that changes in atmospheric pressure and humidity are associated with symptom exacerbation in MD. Improving our understanding of the role of weather and other environmental triggers in Ménière’s may reduce the uncertainty associated with living with this condition, significantly contributing to improved quality of life. PMID:27861300

Meningococcemia

MedlinePlus

... Updated by: Arnold Lentnek, MD, Infectious Diseases Medical Practice of NY and Clinical Research Centers of CT. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical ...

Neurosyphilis

MedlinePlus

... Updated by: Arnold Lentnek, MD, Infectious Diseases Medical Practice of NY and Clinical Research Centers of CT. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical ...

Effectiveness of surgery for adults with hallux valgus deformity: a systematic review.

PubMed

Klugarova, Jitka; Hood, Victoria; Bath-Hextall, Fiona; Klugar, Miloslav; Mareckova, Jana; Kelnarova, Zuzana

2017-06-01

Hallux valgus (HV) is a common foot deformity. In severe stages of this condition, surgery is often necessary. Currently, there is no systematic review comparing the effectiveness of surgery over conservative treatment. The objective of this review was to establish the effectiveness of surgery compared to conservatory management for adults with HV. The current review included adults (18 years or over) with HV deformity, excluding adults with neurological problems causing foot deformities, for example, cerebral palsy, neuropathy, stroke and multiple sclerosis. The review included any type of HV surgery compared to no surgery, conservative treatment or different types of HV surgeries. The primary outcome was gait measurement, and secondary outcomes included quality of life, patient satisfaction, pain assessed using any validated assessment tool and adverse events. The review included randomized controlled trials. The search strategy aimed to find both published and unpublished studies. A three-step search strategy was utilized in 16 databases without language and date limitations. Papers selected for retrieval were assessed by two independent reviewers for methodological validity prior to inclusion in the review using standardized critical appraisal instruments developed by the Joanna Briggs Institute (JBI). Data were extracted from papers included in the review using the standardized data extraction tool developed by the JBI. Quantitative data were, where possible, pooled in statistical meta-analysis using RevMan5 (Copenhagen: The Nordic Cochrane Centre, Cochrane). Effect sizes expressed as risk ratio (for categorical data) and mean differences (MD) or standardized MD (for continuous data) and their 95% confidence intervals were calculated for analysis. Where statistical pooling was not possible, the findings have been presented in narrative form. Searching identified 2412 citations. After removal of duplicates, paper retrieval and critical appraisal, 25 studies were included in the review. The included trials were of medium-to-poor quality.Twenty-four trials compared the effectiveness of different types of surgeries. Meta-analysis revealed no difference in level of pain between distal chevron-type osteotomy and other surgical procedures (standard mean difference [SMD] 0.02, 95% confidence interval [CI] -0.24 to 0.28). One single trial reported that distal chevron osteotomy is more effective than Lindgren osteotomy in terms of walking speed (MD -0.24, 95% CI -0.43 to -0.05).One medium quality trial assessed the effectiveness of HV surgery compared to conservative or no treatment. This trial showed that surgery, specifically distal chevron osteotomy of the first metatarsal, is a more effective procedure for pain compared to conservative treatment (MD -15.00, 95% CI -22.79 to -7.21) and also no treatment in the first year (MD -18.00, 95% CI -25.62 to -10.38). The current systematic review showed that differences between various types of surgical procedures, specifically osteotomies of the first metatarsal on clinical outcomes, are minimal. There is evidence from one study, that surgery, specifically distal chevron osteotomy of the first metatarsal is a more effective procedure than conservative or no treatment in reducing pain in the first year following surgery. However, this systematic review has identified that there is a lack of high-quality studies comparing similar types of HV treatments that assess the same outcomes.

Otosclerosis

MedlinePlus

... Updated by: Sumana Jothi, MD, specialist in laryngology, Assistant Clinical Professor, UCSF Otolaryngology, NCHCS VA, SFVA, San Francisco, CA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, ...

Cholesteatoma

MedlinePlus

... Updated by: Sumana Jothi, MD, specialist in laryngology, Assistant Clinical Professor, UCSF Otolaryngology, NCHCS VA, SFVA, San Francisco, CA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, ...

Mastoiditis

MedlinePlus

... Updated by: Sumana Jothi, MD, specialist in laryngology, Assistant Clinical Professor, UCSF Otolaryngology, NCHCS VA, SFVA, San Francisco, CA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, ...

77 FR 20750 - Special Local Regulations for Marine Events; Potomac River, National Harbor Access Channel, MD

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-06

...-AA08 Special Local Regulations for Marine Events; Potomac River, National Harbor Access Channel, MD...'' triathlon, a marine event to be held on the waters of the Potomac River in Prince George's County, Maryland... portion of the Potomac River and National Harbor Access Channel during the event. DATES: Comments and...

76 FR 60509 - National Institute of Allergy and Infectious Diseases Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-29

... Strategies for Sexual and Reproductive Health''. Date: October 18, 2011. Time: 12:30 p.m. to 5 p.m. Agenda... Drive, Bethesda, MD 20817 (Telephone Conference Call). Contact Person: Jane K. Battles, PhD, Scientific... Health/NIAID, 6700B Rockledge Drive, Room 3147, Bethesda, MD 20892-7616, 301-451-2744, [email protected

78 FR 21864 - Special Local Regulations; Marine Events, Breton Bay; St. Mary's County, Leonardtown, MD

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-12

... temporarily restrict vessel traffic in a portion of Breton Bay during the event. DATES: Comments and related...-AA08 Special Local Regulations; Marine Events, Breton Bay; St. Mary's County, Leonardtown, MD AGENCY... the waters of Breton Bay on July 13, 2013, and July 14, 2013. These special local regulations are...

78 FR 60238 - Proposed Modification and Establishment of Restricted Areas; Aberdeen Proving Ground, MD

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-01

...; Aberdeen Proving Ground, MD AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed..., within the existing restricted areas R-4001A and R- 4001B, at the U.S. Army's Aberdeen Proving Ground in... nonparticipating aircraft from a hazard to navigation in the Aberdeen Proving Ground airspace. DATES: Comments must...

75 FR 63159 - Federal Advisory Committee; Board of Regents of the Uniformed Services University of the Health...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-14

... Uniformed Services University of the Health Sciences AGENCY: Uniformed Services University of the Health... University of the Health Sciences will meet on November 9, 2010, in Bethesda, MD. DATES: The meeting will be...), Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814. FOR...

75 FR 59608 - Amendment of Class D and E Airspace; Establishment of Class E Airspace; Patuxent River, MD

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-28

... River, MD, to reflect the part-time operating status of the control tower, and establishes Class E..., to reflect the part-time operations of the airport control tower, establishing in advance the dates... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 71 [Docket No. FAA-2010...

Extended Storage of Pathogen-Reduced Platelet Concentrates (PRECON)

DTIC Science & Technology

2016-10-01

J. Slichter, MD CONTRACTING ORGANIZATION: Bloodworks Northwest Seattle, WA 98104 REPORT DATE : October 2016 TYPE OF REPORT: Annual Report...NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE October 2016 2. REPORT TYPE Annual 3. DATES COVERED 26-SEP-15 to 25-SEP-16 4. TITLE AND...Platelet Concentrates (PRECON) dated 7/21/14 • Protocol - Cold Apheresis Platelets in Isoplate (CAPI) • Quad Chart 10 Date : 07-21-2014 Project Title

78 FR 65321 - Notice of Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-31

... below for dates of meetings: 1. Healthcare Safety and Quality Improvement Research (HSQR) Date: October... Healthcare Safety and Quality Improvement Research (HSQR), Healthcare Effectiveness and Outcomes Research... Room TBD), 540 Gaither Road, Rockville, MD 20850. FOR FURTHER INFORMATION CONTACT: (to obtain a roster...

60. Photocopy of photograph, no date. DETAIL OF SWITCHBOARD. (Courtesy ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

60. Photocopy of photograph, no date. DETAIL OF SWITCHBOARD. (Courtesy of the Potomac Edison Company Library (Hagerstown, MD), Historical Data Files, Properties-Buildings and Equipment listing) - Dam No. 5 Hydroelectric Plant, On Potomac River, Hedgesville, Berkeley County, WV

Palatal myoclonus

MedlinePlus

... Updated by: Sumana Jothi MD, specialist in laryngology, Assistant Clinical Professor, UCSF Otolaryngology, NCHCS VA, SFVA, San Francisco, CA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, ...

Infectious myringitis

MedlinePlus

... Updated by: Sumana Jothi, MD, specialist in laryngology, Assistant Clinical Professor, UCSF Otolaryngology, NCHCS VA, SFVA, San Francisco, CA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, ...

Aural polyps

MedlinePlus

... Updated by: Sumana Jothi, MD, specialist in laryngology, Assistant Clinical Professor, UCSF Otolaryngology, NCHCS VA, SFVA, San Francisco, CA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, ...

78 FR 9309 - Airworthiness Directives; MD Helicopters, Inc., Helicopters

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-08

... date, creating a component record card for each T-T strap, and revising the airworthiness limitations..., marking each T-T strap with the expiration date, creating a component record card for each T-T strap, and... date; creating a component record card for each affected T-T strap; replacing T-T straps that have been...

Malignant otitis externa

MedlinePlus

... Updated by: Sumana Jothi, MD, specialist in laryngology, Assistant Clinical Professor, UCSF Otolaryngology, NCHCS VA, SFVA, San Francisco, CA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, ...

Convergence and reproducibility in molecular dynamics simulations of the DNA duplex d(GCACGAACGAACGAACGC)

PubMed Central

Galindo-Murillo, Rodrigo; Roe, Daniel R.; Cheatham, Thomas E.

2014-01-01

Background The structure and dynamics of DNA are critically related to its function. Molecular dynamics (MD) simulations augment experiment by providing detailed information about the atomic motions. However, to date the simulations have not been long enough for convergence of the dynamics and structural properties of DNA. Methods MD simulations performed with AMBER using the ff99SB force field with the parmbsc0 modifications, including ensembles of independent simulations, were compared to long timescale MD performed with the specialized Anton MD engine on the B-DNA structure d(GCACGAACGAACGAACGC). To assess convergence, the decay of the average RMSD values over longer and longer time intervals was evaluated in addition to assessing convergence of the dynamics via the Kullback-Leibler divergence of principal component projection histograms. Results These MD simulations —including one of the longest simulations of DNA published to date at ~44 μs—surprisingly suggest that the structure and dynamics of the DNA helix, neglecting the terminal base pairs, are essentially fully converged on the ~1–5 μs timescale. Conclusions We can now reproducibly converge the structure and dynamics of B-DNA helices, omitting the terminal base pairs, on the μs time scale with both the AMBER and CHARMM C36 nucleic acid force fields. Results from independent ensembles of simulations starting from different initial conditions, when aggregated, match the results from long timescale simulations on the specialized Anton MD engine. General Significance With access to large-scale GPU resources or the specialized MD engine “Anton” it is possibly for a variety of molecular systems to reproducibly and reliably converge the conformational ensemble of sampled structures. PMID:25219455

Thalassemia

MedlinePlus

... 19/2018 Updated by: Richard LoCicero, MD, private practice specializing in hematology and medical oncology, Longstreet Cancer Center, Gainesville, GA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical ...

17. Photocopy of a photograph, source and date unknown GENERAL ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

17. Photocopy of a photograph, source and date unknown GENERAL VIEW OF FRONT FACADE OF MT. CLARE STATION; PASSENGER CAR SHOP IN REAR - Baltimore & Ohio Railroad, Mount Clare Passenger Car Shop, Southwest corner of Pratt & Poppleton Streets, Baltimore, Independent City, MD

58. Photocopy of photograph, no date. VIEW OF GENERATOR UNIT ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

58. Photocopy of photograph, no date. VIEW OF GENERATOR UNIT 2. (Courtesy of the Potomac Edison Company Library (Hagerstown, MD), Historical Data Files, Properties-Buildings and Equipment listing) - Dam No. 5 Hydroelectric Plant, On Potomac River, Hedgesville, Berkeley County, WV

78 FR 28845 - Ocean Transportation Intermediary License Revocations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-16

..., 2013. Reason: Failed to maintain valid bonds. License No.: 015187N. Name: Gage Shipping Lines, Ltd. Address: 23 South Street, Baltimore, MD 21202. Date Revoked: April 26, 2013. Reason: Failed to maintain a..., Miami, FL 33178. Date Revoked: April 22, 2013. [[Page 28846

BAER - brainstem auditory evoked response

MedlinePlus

... Updated by: Sumana Jothi, MD, specialist in laryngology, Assistant Clinical Professor, UCSF Otolaryngology, NCHCS VA, SFVA, San Francisco, CA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, ...

Benign ear cyst or tumor

MedlinePlus

... Updated by: Sumana Jothi, MD, specialist in laryngology, Assistant Clinical Professor, UCSF Otolaryngology, NCHCS VA, SFVA, San Francisco, CA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, ...

78 FR 25459 - Notice of Diabetes Mellitus Interagency Coordinating Committee Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-01

... (Building 38A), National Library of Medicine, on the NIH Campus at 8600 Rockville Pike, Bethesda, MD 20894. The meeting is open to the public. DATES: The meeting will be held on May 23, 2013 from 1:00 to 3:30 p... (Building 38A), National Library of Medicine, on the NIH Campus at 8600 Rockville Pike, Bethesda, MD 20894...

77 FR 56115 - Safety Zone for Fireworks Display, Potomac River, National Harbor Access Channel; Oxon Hill, MD

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-12

..., MD AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a... safety of life on navigable waters during a fireworks display launched from a floating platform located... zone is intended to protect the maritime public in a portion of the Potomac River. DATES: This rule is...

75 FR 1796 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-13

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... grant applications. Place: National Institute of Health, 6710 Rockledge Drive, Bethesda, MD 20892... Review, National Institutes of Health, 6701 Rockledge Drive, Room 2212, MSC 7890, Bethesda, MD 20892...

78 FR 48880 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-12

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... grant applications. Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892... Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Room 5194, MSC 7846, Bethesda, MD...

Hemophilia Treatments Have Come a Long Way

MedlinePlus

... Nisha Jain, M.D., chief of the Clinical Review Branch in FDA’s Office of Blood Research and Review. Hemophilia A occurs when people have low levels, ... Nisha Jain, M.D., chief of the Clinical Review Branch in FDA’s Office of Blood Research and ...

Molecular Dynamics of Hot Dense Plasmas: New Horizons

NASA Astrophysics Data System (ADS)

Graziani, Frank

2011-10-01

We describe the status of a new time-dependent simulation capability for hot dense plasmas. The backbone of this multi-institutional computational and experimental effort--the Cimarron Project--is the massively parallel molecular dynamics (MD) code ``ddcMD''. The project's focus is material conditions such as exist in inertial confinement fusion experiments, and in many stellar interiors: high temperatures, high densities, significant electromagnetic fields, mixtures of high- and low- Zelements, and non-Maxwellian particle distributions. Of particular importance is our ability to incorporate into this classical MD code key atomic, radiative, and nuclear processes, so that their interacting effects under non-ideal plasma conditions can be investigated. This talk summarizes progress in computational methodology, discusses strengths and weaknesses of quantum statistical potentials as effective interactions for MD, explains the model used for quantum events possibly occurring in a collision and highlights some significant results obtained to date. We describe the status of a new time-dependent simulation capability for hot dense plasmas. The backbone of this multi-institutional computational and experimental effort--the Cimarron Project--is the massively parallel molecular dynamics (MD) code ``ddcMD''. The project's focus is material conditions such as exist in inertial confinement fusion experiments, and in many stellar interiors: high temperatures, high densities, significant electromagnetic fields, mixtures of high- and low- Zelements, and non-Maxwellian particle distributions. Of particular importance is our ability to incorporate into this classical MD code key atomic, radiative, and nuclear processes, so that their interacting effects under non-ideal plasma conditions can be investigated. This talk summarizes progress in computational methodology, discusses strengths and weaknesses of quantum statistical potentials as effective interactions for MD, explains the model used for quantum events possibly occurring in a collision and highlights some significant results obtained to date. This work is performed under the auspices of the U. S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

Probiotics for the Treatment of Atopic Dermatitis in Children: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

PubMed

Huang, Ruixue; Ning, Huacheng; Shen, Minxue; Li, Jie; Zhang, Jianglin; Chen, Xiang

2017-01-01

Objective: Atopic dermatitis (AD) is a prevalent, burdensome, and psychologically important pediatric concern. Probiotics have been suggested as a treatment for AD. Some reports have explored this topic; however, the utility of probiotics for AD remains to be firmly established. Methods: To assess the effects of probiotics on AD in children, the PubMed/Medline, Cochrane Library Scopus, and OVID databases were searched for reports published in the English language. Results: Thirteen studies were identified. Significantly higher SCORAD values favoring probiotics over controls were observed (mean difference [MD], -3.07; 95% confidence interval [CI], -6.12 to -0.03; P < 0.001). The reported efficacy of probiotics in children < 1 year old was -1.03 (95%CI, -7.05 to 4.99) and that in children 1-18 years old was -4.50 (95%CI, -7.45 to -1.54; P < 0.001). Subgroup analyses showed that in Europe, SCORAD revealed no effect of probiotics, whereas significantly lower SCORAD values were reported in Asia (MD, -5.39; 95%CI, -8.91 to -1.87). Lactobacillus rhamnosus GG (MD, 3.29; 95%CI, -0.30 to 6.88; P = 0.07) and Lactobacillus plantarum (MD, -0.70; 95%CI, -2.30 to 0.90; P = 0.39) showed no significant effect on SCORAD values in children with AD. However, Lactobacillus fermentum (MD, -11.42; 95%CI, -13.81 to -9.04), Lactobacillus salivarius (MD, -7.21; 95%CI, -9.63 to -4.78), and a mixture of different strains (MD, -3.52; 95%CI, -5.61 to -1.44) showed significant effects on SCORAD values in children with AD. Conclusions: Our meta-analysis indicated that the research to date has not robustly shown that probiotics are beneficial for children with AD. However, caution is needed when generalizing our results, as the populations evaluated were heterogeneous. Randomized controlled trials with larger samples and greater power are necessary to identify the species, dose, and treatment duration of probiotics that are most efficacious for treating AD in children.

76 FR 23829 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-28

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... applications. Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892, (Telephone... Review, National Institutes of Health, 6701 Rockledge Drive, Room 2176, MSC 7818, Bethesda, MD 20892, 301...

77 FR 55851 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-11

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... grant applications. Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892... Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Room 5217A, MSC 7846, Bethesda, MD...

77 FR 48527 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-14

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Room 4150, MSC 7806, Bethesda, MD... Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892, (Telephone Conference Call). Contact Person...

77 FR 66854 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-07

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... evaluate grant applications. Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892... Review, National Institutes of Health, 6701 Rockledge Drive, Room 4118, MSC 7814, Bethesda, MD 20892, 301...

78 FR 40756 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-08

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... evaluate grant applications. Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892... Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Room 5186, MSC 7846, Bethesda, MD...

Past major depression and smoking cessation outcome: a systematic review and meta-analysis update

PubMed Central

Hitsman, Brian; Papandonatos, George D.; McChargue, Dennis E.; DeMott, Andrew; Herrera, María José; Spring, Bonnie; Borrelli, Belinda; Niaura, Raymond

2012-01-01

Aims To update our prior meta-analysis that showed past major depression (MD+) to be unrelated to smoking cessation outcome [Hitsman et al. J Consult Clin Psychol 2003; 71:657–63]. Methods Eligible trials included 14 from our original review and 28 identified through an updated systematic review (2000–2009). We coded for assessment of past MD, exclusion for recent MD episode (MDE; ≤6 months versus no exclusion), duration/modality of cognitive behavioral treatment (CBT; face-to-face versus self-help), and other factors. To minimize influence of experimental treatments that may selectively benefit MD+ smokers, we analyzed placebo/lowest intensity control arms only. Study-specific odds ratios (ORs) for the effect of past MD on short-term (≤3 months) and long-term (≥6 months) abstinence were estimated and combined using random effects. Two-way interaction models of past MD with study methodology and treatment factors were used to evaluate hypothesized moderators of the past MD-abstinence association. Results MD+ smokers had 17% lower odds of short-term abstinence (n=35, OR=0.83, 95% CI=0.72–0.95, p=0.009) and 19% lower odds of long-term abstinence (n=38, OR=0.81, 95% CI=0.67–0.97, p=0.023) than MD− smokers after excluding the sole study of varenicline because of its antidepressant properties. The association between past MD and abstinence was affected by methodological (recent MDE exclusion, type of MD assessment) and treatment (CBT modality) factors. Conclusions Past major depression has a modest adverse effect on abstinence during and after smoking cessation treatment. An increased focus on the identification of effective treatments or treatment adaptations that eliminate this disparity in smoking cessation for MD+ smokers is needed. PMID:23072580

75 FR 54159 - Center for Scientific Review; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-03

..., MD 20892 (Telephone Conference Call). Contact Person: Daniel F McDonald, PhD, Scientific Review... 7814, Bethesda, MD 20892, (301) 435-1215, mcdonald@csr.nih.gov . This notice is being published less...

Enhanced sampling simulations to construct free-energy landscape of protein-partner substrate interaction.

PubMed

Ikebe, Jinzen; Umezawa, Koji; Higo, Junichi

2016-03-01

Molecular dynamics (MD) simulations using all-atom and explicit solvent models provide valuable information on the detailed behavior of protein-partner substrate binding at the atomic level. As the power of computational resources increase, MD simulations are being used more widely and easily. However, it is still difficult to investigate the thermodynamic properties of protein-partner substrate binding and protein folding with conventional MD simulations. Enhanced sampling methods have been developed to sample conformations that reflect equilibrium conditions in a more efficient manner than conventional MD simulations, thereby allowing the construction of accurate free-energy landscapes. In this review, we discuss these enhanced sampling methods using a series of case-by-case examples. In particular, we review enhanced sampling methods conforming to trivial trajectory parallelization, virtual-system coupled multicanonical MD, and adaptive lambda square dynamics. These methods have been recently developed based on the existing method of multicanonical MD simulation. Their applications are reviewed with an emphasis on describing their practical implementation. In our concluding remarks we explore extensions of the enhanced sampling methods that may allow for even more efficient sampling.

Prevention of Infections Associated With Combat-Related Eye, Maxillofacial, and Neck Injuries

DTIC Science & Technology

2011-08-01

REVIEW ARTICLE Prevention of Infections Associated With Combat-Related Eye, Maxillofacial, and Neck Injuries Kyle Petersen, DO, FACP, FIDSA...Marcus H Colyer, MD, David K. Hayes, MD, FACS, Robert G. Hale, DDS, R. B1yan Bell, DDS, MD, FACS, and the Prevention of Combat-Related Infections ...article reviews recent data from military and civilian studies to support evidence-based recommendations for the prevention of infections associated

Development of a Blood-Based Biomarker Panel for Indeterminate Lung Nodules

DTIC Science & Technology

2016-09-01

Taguchi CONTRACTING ORGANIZATION: University of Texas MD Anderson Cancer Center Houston, TX 77030 REPORT DATE: September 2016 TYPE OF REPORT...PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER University of Texas MD Anderson Cancer Center Rene...protein, autoantibody and microRNA) to distinguish malignant lung nodules from benign lung nodules. We have so far assayed 20 protein markers, 122

Quality of life in age-related macular degeneration: a review of the literature

PubMed Central

Mitchell, Jan; Bradley, Clare

2006-01-01

Background The Age-related Macular Degeneration Alliance International commissioned a review of the literature on quality of life (QoL) in macular degeneration (MD) with a view to increasing awareness of MD, reducing its impact and improving services for people with MD worldwide. Method A systematic review was conducted using electronic databases, conference proceedings and key journal hand search checks. The resulting 'White Paper' was posted on the AMD Alliance website and is reproduced here. Review MD is a chronic, largely untreatable eye condition which leads to loss of central vision needed for tasks such as reading, watching TV, driving, recognising faces. It is the most common cause of blindness in the Western world. Shock of diagnosis, coupled with lack of information and support are a common experience. Incidence of depression is twice that found in the community-dwelling elderly, fuelled by functional decline and loss of leisure activities. Some people feel suicidal. MD threatens independence, especially when comorbidity exacerbates functional limitations. Rehabilitation, including low vision aid (LVA) provision and training, peer support and education, can improve functional and psychological outcomes but many people do not receive services likely to benefit them. Medical treatments, suitable for only a small minority of people with MD, can improve vision but most limit progress of MD, at least for a time, rather than cure. The White Paper considers difficulties associated with inappropriate use of health status measures and misinterpretation of utility values as QoL measures: evidence suggests they have poor validity in MD. Conclusion There is considerable evidence for the major damage done to QoL by MD which is underestimated by health status and utility measures. Medical treatments are limited to a small proportion of people. However, much can be done to improve QoL by early diagnosis of MD with good communication of prognosis and continuing support. Support could include provision of LVAs, peer support, education and effective help in adjusting to MD. It is vital that appropriate measures of visual function and QoL be used in building a sound evidence base for the effectiveness of rehabilitation and treatment. PMID:17184527

78 FR 52513 - Sunshine Act Meeting; Cancellation

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-23

..., August 21, 2013, page 51713. ANNOUNCED TIME AND DATE OF MEETING: Wednesday, August 21, 2013, 10 a.m.-11 a.m. MEETING CANCELED. For a recorded message containing the latest agenda information, call (301) 504... West Highway, Bethesda, MD 20814 (301) 504- 7923. Dated: August 21, 2013. Todd A. Stevenson, Secretary...

75 FR 65017 - Ocean Transportation Intermediary License Revocations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-21

...: 6701 Moravia Park Drive, Unit B, Baltimore, MD 21237. Date Revoked: September 17, 2010. Reason: Failed.... License Number: 018717N. Name: IFE Global Logistics Inc. Address: 100 North Hill Drive, 16, Brisbane, CA... Logistics Inc. Address: 1001 Nicholas Blvd., A, Elk Grove Village, IL 60007. Date Revoked: September 10...

77 FR 64992 - Ocean Transportation Intermediary License Revocations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-24

...: Logistics, Inc. Address: 313 West Arundel Road, Baltimore, MD 21225. Date Revoked: September 21, 2012... Monterey Pass Road, Suite C, Monterey Park, CA 91754. Date Revoked: September 5, 2012. Reason: Failed to....: 019327N. Name: David A. Knott dba Dak Logistics Services. Address: 131-E Sunset Avenue, Suite 210, Suisun...

Pathogen-Reduced, Platelet Additive Solution, Extended Stored Platelets (PREPS)

DTIC Science & Technology

2015-10-01

Sherrill J. Slichter, MD CONTRACTING ORGANIZATION: Bloodworks Northwest Seattle, WA 98104 REPORT DATE : October 2015 TYPE OF REPORT: Annual...NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE October 2015 2. REPORT TYPE Annual 3. DATES COVERED 15-SEP-14 to 14-SEP-15 4. TITLE AND...accomplishments to date . Brrr Study Our study of platelets stored as whole blood at 4°C demonstrated that end-over-end rotation is required to reduce platelet

Pathogen-Reduced, Extended Platelet Storage in Platelet Additive Solution (PAS)

DTIC Science & Technology

2016-10-01

Sherrill J. Slichter, MD CONTRACTING ORGANIZATION: Bloodworks Northwest Seattle, WA 98104 REPORT DATE : October 2016 TYPE OF REPORT: Annual...PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE October 2016 2. REPORT TYPE Annual 3. DATES COVERED 15-SEP-15 to 14-SEP-16 4...the key research outcomes to date . Brrr Study Our study of platelets stored as whole blood at 4°C demonstrated that end-over-end rotation is required

Extended Storage of Pathogen Reduced Platelet Concentrates (PRECON)

DTIC Science & Technology

2015-10-01

J. Slichter, MD CONTRACTING ORGANIZATION: Bloodworks Northwest Seattle, WA 98104 REPORT DATE : October 2015 TYPE OF REPORT: Annual PREPARED FOR...YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE October 2015 2. REPORT TYPE Annual 3. DATES COVERED 26 Sep 2014 - 25 Sep 2015 4. TITLE AND SUBTITLE...accomplishments to date . Brrr Study Our study of platelets stored as whole blood at 4°C demonstrated that end-over-end rotation is required to reduce platelet

76 FR 81951 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-29

..., Bethesda, MD 20892 (Virtual Meeting). Contact Person: Ai-Ping Zou, MD, Ph.D., Scientific Review Officer... Nos. 93.306, Comparative Medicine; 93.333, Clinical Research; 93.306, 93.333, 93.337, 93.393-93.396...

Efficacy of musculoskeletal manual approach in the treatment of temporomandibular joint disorder: A systematic review with meta-analysis.

PubMed

Martins, Wagner Rodrigues; Blasczyk, Juscelino Castro; Aparecida Furlan de Oliveira, Micaele; Lagôa Gonçalves, Karina Ferreira; Bonini-Rocha, Ana Clara; Dugailly, Pierre-Michel; de Oliveira, Ricardo Jacó

2016-02-01

Temporomandibular joint disorder (TMD) requires a complex diagnostic and therapeutic approach, which usually involves a multidisciplinary management. Among these treatments, musculoskeletal manual techniques are used to improve health and healing. To assess the effectiveness of musculoskeletal manual approach in temporomandibular joint disorder patients. A systematic review with meta-analysis. During August 2014 a systematic review of relevant databases (PubMed, The Cochrane Library, PEDro and ISI web of knowledge) was performed to identify controlled clinical trials without date restriction and restricted to the English language. Clinical outcomes were pain and range of motion focalized in temporomandibular joint. The mean difference (MD) or standard mean difference (SMD) with 95% confidence intervals (CIs) and overall effect size were calculated at every post treatment. The PEDro scale was used to demonstrate the quality of the included studies. From the 308 articles identified by the search strategy, 8 articles met the inclusion criteria. The meta-analysis showed a significant difference (p < 0.0001) and large effect on active mouth opening (SMD, 0.83; 95% CI, 0.42 to 1.25) and on pain during active mouth opening (MD, 1.69; 95% CI, 1.09 to 2.30) in favor of musculoskeletal manual techniques when compared to other conservative treatments for TMD. Musculoskeletal manual approaches are effective for treating TMD. In the short term, there is a larger effect regarding the latter when compared to other conservative treatments for TMD. Copyright © 2015 Elsevier Ltd. All rights reserved.

Modeling Aggressive Medulloblastoma Using Human-Induced Pluripotent Stem Cells

DTIC Science & Technology

2015-07-01

Mingyao Ying, Ph.D. CONTRACTING ORGANIZATION: Hugo W. Moser Research Institute at Kennedy Krieger , Inc., Baltimore, MD 21205 REPORT DATE...Cells W81XWH-14-1-0176 Mingyao Ying, Ph.D. Ying@kennedykrieger.org Hugo W. Moser Research Institute at Kennedy Krieger , Inc. Baltimore, MD 21205...medulloblastoma model derived from human induced pluripotent stem cells. Jonathan Sagal1, Charles G. Eberhart2, Mingyao Ying1. 1Kennedy Krieger

Checklist and Decision Support in Nutritional Care for Burned Patients

DTIC Science & Technology

2014-10-01

in Nutritional Care for Burned Patients PRINCIPAL INVESTIGATOR: Steven E. Wolf, MD CONTRACTING ORGANIZATION: REPORT DATE... Nutritional Care for Burned Patients 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Steven E Wolf, MD Betty Diamond...Study/Product Aim(s) were as follows: 1) To determine under what conditions compliance with nutritional goals are not met in severely burned adults, 2

Multifunctional PSCA Antibody Fragments for PET and Optical Prostate Cancer Imaging

DTIC Science & Technology

2016-10-01

INVESTIGATOR: Robert E. Reiter, MD, MBA CONTRACTING ORGANIZATION: University of California, Los Angeles Los Angeles, CA 90095-1406 REPORT DATE ...currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE October 2016 2. REPORT TYPE Annual 3. DATES COVERED...expressed in prostate cancer. These engineered antibody fragments (cys-minibodies and cys-diabodies) can be labeled with radioisotopes for non- invasive

78 FR 41298 - Children's Products Containing Lead; Procedures and Requirements for Exclusions From Lead Limits...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-10

... changes mandated by Public Law 112-28. DATES: Effective Date: July 10, 2013. FOR FURTHER INFORMATION... Highway, Bethesda, MD 20814; email: [email protected] ; telephone: 301-504-7632. SUPPLEMENTARY INFORMATION... section by removing the excessive lead or by making the lead inaccessible; (B) The product, class of...

Symptomatic Meckel's diverticulum in newborn: two interesting additional cases and review of literature.

PubMed

Bertozzi, Mirko; Melissa, Berardino; Radicioni, Maurizio; Magrini, Elisa; Appignani, Antonino

2013-09-01

This study aimed to review the literature about symptomatic Meckel's diverticulum (MD) in the neonatal period with 2 additional uncommon cases. The authors describe 2 interesting neonatal cases of symptomatic MD and analyze the literature on this topic, with particular reference to the prevalence of sex, age at presentation, most common signs and symptoms, treatment, histology, associated anomalies, and outcome. The first patient was a term newborn with bowel obstruction by a pseudocystic MD. The second patient was a preterm infant with double perforation of the MD and ileum. Literature search for published case reports and case series on this topic reveals only 18 cases of neonatal symptomatic MD. Males are more frequently involved than females, and even preterm infants may be affected. Bowel obstruction (58.3%) and pneumoperitoneum (33.3%) are the most frequent clinical manifestation. Acute inflammation of the MD is the prominent histopathological finding (75%), although it does not seem to be related with the presence of heterotopic tissue within the MD. Surgical treatment is essential. The association of neonatal symptomatic MD with other anomalies is exceptional but is otherwise life threatening despite surgery. Bowel obstruction and pneumoperitoneum are the most frequent clinical manifestations of symptomatic MD in the newborn. Surgery is required for a definitive diagnosis and successful outcome.

Hyperbaric Versus Isobaric Bupivacaine for Spinal Anesthesia: Systematic Review and Meta-analysis for Adult Patients Undergoing Noncesarean Delivery Surgery.

PubMed

Uppal, Vishal; Retter, Susanne; Shanthanna, Harsha; Prabhakar, Christopher; McKeen, Dolores M

2017-11-01

It is widely believed that the choice between isobaric bupivacaine and hyperbaric bupivacaine formulations alters the block characteristics for the conduct of surgery under spinal anesthesia. The aim of this study was to systematically review the comparative evidence regarding the effectiveness and safety of the 2 formulations when used for spinal anesthesia for adult noncesarean delivery surgery. Key electronic databases were searched for randomized controlled trials, excluding cesarean delivery surgeries under spinal anesthesia, without any language or date restrictions. The primary outcome measure for this review was the failure of spinal anesthesia. Two independent reviewers selected the studies and extracted the data. Results were expressed as relative risk (RR) or mean differences (MDs) with 95% confidence intervals (CIs). Seven hundred fifty-one studies were identified between 1946 and 2016. After screening, there were 16 randomized controlled clinical trials, including 724 participants, that provided data for the meta-analysis. The methodological reporting of most studies was poor, and appropriate judgment of their individual risk of bias elements was not possible. There was no difference between the 2 drugs regarding the need for conversion to general anesthesia (RR, 0.60; 95% CI, 0.08-4.41; P = .62; I = 0%), incidence of hypotension (RR, 1.15; 95% CI, 0.69-1.92; P = .58; I = 0%), nausea/vomiting (RR, 0.29; 95% CI, 0.06-1.32; P = .11; I = 7%), or onset of sensory block (MD = 1.7 minutes; 95% CI, -3.5 to 0.1; P = .07; I = 0%). The onset of motor block (MD = 4.6 minutes; 95% CI, 7.5-1.7; P = .002; I = 78%) was significantly faster with hyperbaric bupivacaine. Conversely, the duration of motor (MD = 45.2 minutes; 95% CI, 66.3-24.2; P < .001; I = 87%) and sensory (MD = 29.4 minutes; 95% CI, 15.5-43.3; P < .001; I = 73%) block was longer with isobaric bupivacaine. Both hyperbaric bupivacaine and isobaric bupivacaine provided effective anesthesia with no difference in the failure rate or adverse effects. The hyperbaric formulation allows for a relatively rapid motor block onset, with shorter duration of motor and sensory block. The isobaric formulation has a slower onset and provides a longer duration of both sensory and motor block. Nevertheless, the small sample size and high heterogeneity involving these outcomes suggest that all the results should be treated with caution.

78 FR 38999 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-28

..., (Virtual Meeting). Contact Person: Elena Smirnova, Ph.D., Scientific Review Officer, Center for Scientific... of Health, 6701 Rockledge Drive, Bethesda, MD 20892, (Virtual Meeting). Contact Person: Kenneth A... Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892, (Virtual Meeting). Contact Person: Krish...

77 FR 16248 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-20

... (Virtual Meeting). Contact Person: Kenneth A Roebuck, Ph.D., Scientific Review Officer, Center for... Rockledge Drive, Bethesda, MD 20892 (Virtual Meeting). Contact Person: Robert Freund, Ph.D., Scientific.... Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892 (Virtual Meeting...

Female condoms

MedlinePlus

... of Gynecology and Obstetrics at Johns Hopkins University School of Medicine, Baltimore, MD. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team. Birth Control Read more NIH MedlinePlus Magazine Read more Health ...

Clinical efficacy of photodynamic therapy adjunctive to scaling and root planing in the treatment of chronic periodontitis: A systematic review and meta-analysis.

PubMed

Xue, Dong; Tang, Lu; Bai, Yuhao; Ding, Qian; Wang, Pengcheng; Zhao, Ying

2017-06-01

To evaluate the clinical efficacy of photodynamic therapy (PDT) adjunctive to scaling and root planing (SRP) in patients with untreated chronic periodontitis based on up-to-date evidence. MEDLINE and the Cochrane Library were systematically searched to identify eligible randomized controlled trials (RCTs), supplemented by a manual literature search. Mean differences (MD) and the corresponding 95% confidence intervals (CI) of probing depth (PD) reduction and clinical attachment level (CAL) gain were synthesized. The I 2 test and Q statistics were used to determine the inter-study heterogeneity. Subgroup analysis based on smoking status was performed. Eleven RCTs with a total of 243 subjects were included. Significant improvement in PD reduction (MD=0.13, CI:0.02-0.24, p=0.02) and marginal significant improvement in CAL gain (MD=0.18, CI:-0.005-0.363, p=0.056) were observed in favor of SRP+PDT at 3months. When evaluated at 6months after baseline, the association of PDT with SRP resulted in a significant benefit in PD reduction (MD=0.40, CI:0.05-0.74, p=0.03), but not in CAL gain (MD=0.37, CI:-0.18-0.93, p=0.18). Subgroup analysis revealed that the combined therapy produced no significant improvements in PD and CAL at neither 3months nor 6months for studies with smokers. No treatment-related adverse events or side effects had been reported by the included studies. Pooled analysis suggests a short-term benefit of PDT as an adjunct to SRP in clinical outcome variables. However, evidence regarding its long-term efficacy is still insufficient and no significant effect has been confirmed in terms of CAL gain at 6months. Future clinical trials of high methodological quality are needed to establish the optimal combination of photosensitizer and laser configuration. Copyright © 2017 Elsevier B.V. All rights reserved.

Nasal Irrigation for Chronic Rhinosinusitis and Fatigue in Patients with Gulf War Syndrome

DTIC Science & Technology

2015-07-01

Syndrome ” PRINCIPAL INVESTIGATOR: David Rabago, MD CONTRACTING ORGANIZATION: University of Wisconsin Systems Board of Regents REPORT DATE...Patients with Gulf War Syndrome ” 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) David Rabago, MD 5d. PROJECT NUMBER 5e. TASK NUMBER...Rhinosinusitis, Fatigue, Gulf War Syndrome , Nasal Irrigation 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18. NUMBER OF PAGES 19a

Does psychosis increase the risk of suicide in patients with major depression? A systematic review.

PubMed

Zalpuri, Isheeta; Rothschild, Anthony J

2016-07-01

Over the years studies have shown conflicting results about the risk of suicide in psychotic depression (MD-psych). To understand this association, we undertook a comprehensive review of the literature to ascertain whether individuals with MD-psych have higher rates of completed suicides, suicide attempts or suicidal ideation compared to those with non-psychotic depression (MD-nonpsych). We searched Pubmed, PsycINFO and Ovid in English language, from 1946-October 2015. Studies were included if suicidal ideation, attempts or completed suicides were assessed. During the acute episode of depression, patients with MD-psych have higher rates of suicide, suicide attempts, and suicidal ideation than patients with MD-nonpsych, especially when the patient is hospitalized on an inpatient psychiatric unit. Studies done after the acute episode has resolved are less likely to show this difference, likely due to patients having received treatment. Diagnostic interviews were not conducted in all studies. Many studies did not report whether psychotic symptoms in MD-psych patients were mood-congruent or mood-incongruent; hence it is unclear whether the type of delusion increases suicide risk. Studies did not describe whether MD-psych patients experienced command hallucinations encouraging them to engage in suicidal behavior. Only 24 studies met inclusion criteria; several of them had small sample size and a quality score of zero, hence impacting validity. This review indicates that the seemingly conflicting data in suicide risk between MD-psych and MD-nonpsych in previous studies appears to be related to whether one looks at differences during the acute episode or over the long-term. Copyright © 2016 Elsevier B.V. All rights reserved.

Continuous nasogastric milk feeding versus intermittent bolus milk feeding for premature infants less than 1500 grams.

PubMed

Premji, Shahirose S; Chessell, Lorraine

2011-11-09

Milk feedings can be given via nasogastric tube either intermittently, typically over 10 to 20 minutes every two or three hours, or continuously, using an infusion pump. Although theoretical benefits and risks of each method have been proposed, effects on clinically important outcomes remain uncertain. To examine the evidence regarding the effectiveness of continuous versus intermittent bolus nasogastric milk feeding in premature infants less than 1500 grams. Searches were performed of the Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library, Issue 3, 2011), MEDLINE, CINAHL and HealthSTAR up to July 2011. Randomised and quasi-randomised clinical trials comparing continuous versus intermittent bolus nasogastric milk feeding in premature infants less than 1500 grams. Two review authors independently assessed all trials for relevance and methodologic quality. The standard methods of the Cochrane Neonatal Review Group were used to extract data. Overall, the seven included trials, involving 511 infants, found no differences in time to achieve full enteral feeds between feeding methods (weighted mean difference (WMD) 2 days; 95% CI -0.3 to 3.9) . In the subgroup analysis of those studies comparing continuous nasogastric versus intermittent bolus nasogastric milk feedings the findings remained unchanged (WMD 2 days, 95% CI -0.4 to 4.1). There was no significant difference in somatic growth and incidence of NEC between feeding methods irrespective of tube placement. One study noted a trend toward more apneas during the study period in infants fed by the continuous tube feeding method compared to those fed by intermittent feedings delivered predominantly by orogastric tube placements [mean difference (MD) 14.0 apneas during study period; 95% CI -0.2 to 28.2]. In subgroup analysis based on weight groups, one study suggested that infants less than 1000 grams and 1000 to 1250 grams birth weight gained weight faster when fed by the continuous nasogastric tube feeding method compared to intermittent nasogastric tube feeding method (MD 2.0 g/day; 95% CI 0.5 to 3.5; MD 2.0 g/day; 95% CI 0.2 to 3.8, respectively). A trend toward earlier discharge for infants less than 1000 grams birth weight fed by the continuous tube feeding method compared to intermittent nasogastric tube feeding method (MD -11 days; 95% CI -21.8 to -0.2). Small sample sizes, methodologic limitations, inconsistencies in controlling variables that may affect outcomes, and conflicting results of the studies to date make it difficult to make universal recommendations regarding the best tube feeding method for premature infants less than 1500 grams. The clinical benefits and risks of continuous versus intermittent nasogastric tube milk feeding cannot be reliably discerned from the limited information available from randomised trials to date.

76 FR 59707 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-27

..., (Virtual Meeting). Contact Person: Rebecca Henry, PhD, Scientific Review Officer, Center for Scientific... Rockledge Drive, Bethesda, MD 20892, (Virtual Meeting). Contact Person: George M Barnas, PhD, Scientific... Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892, (Virtual Meeting). Contact Person: George M...

Birth control pills - overview

MedlinePlus

... of Gynecology and Obstetrics at Johns Hopkins University School of Medicine, Baltimore, MD. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team. Birth Control Read more NIH MedlinePlus Magazine Read more Health ...

Evaluation of the Protective Efficacy of Recombinant Vesicular Stomatitis Virus Vectors Against Marburg Hemorrhagic Fever in Nonhuman Primate Models

DTIC Science & Technology

2007-01-19

fever in Nonhuman Primate Models" Date d?JO )oi Date )&*7 Date Dissertation and Abstract Approved: Robert Friedm ,M.D. Department of Pathology Committee...thesis manuscript entitled: "Evaluation of the Protective Efficacy of Recombinant Vesicular Stomatitis Virus Vectors Against Marburg Hemorrhagic fever ...stomatitis virus vectors against Marburg hemorrhagic fever in nonhuman primate models By Kathleen Daddario-DiCaprio Dissertation

Extended Storage of Pathogen-Reduced Platelet Concentrates (PRECON)

DTIC Science & Technology

2017-12-01

J. Slichter, MD CONTRACTING ORGANIZATION: Bloodworks Northwest Seattle, WA 98104 REPORT DATE : December 2017 TYPE OF REPORT: Final PREPARED FOR...YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE December 2017 2. REPORT TYPE Final 3. DATES COVERED 26-SEP-13 to 25-SEP-17 4. TITLE AND SUBTITLE...comparator. Both the stored and the fresh platelets 4 were administered simultaneously using two different radioisotopes ( ≤15 μCi of indium for the

Treatment of Early Post-op Wound Infection after Internal Fixation

DTIC Science & Technology

2015-10-01

Obremskey, M.D. CONTRACTING ORGANIZATION: Vanderbilt University Medical Center Nashville TN 37203 REPORT DATE: October 2015 TYPE OF REPORT: Annual...PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE (DD-MM-YYYY) October 2015 2. REPORT TYPE Annual 3. DATES COVERED (From - To...either: (Group 1) operative debridement and PO antibiotic treatment for 6 weeks; or (Group 2) operative debridement and IV antibiotics for 6 weeks and

Bicarbonate versus lactate solutions for acute peritoneal dialysis.

PubMed

Bai, Zheng Gang; Yang, KeHu; Tian, Jin Hui; Ma, Bin; Liu, Yali; Jiang, Lei; Tan, Jiying; Liu, Tian Xi; Chi, Iris

2014-07-04

The high mortality rate among critically ill patients with acute kidney injury (AKI) remains an unsolved problem in intensive care medicine, despite the use of renal replacement therapy (RRT). Increasing evidence from clinical studies in adults and children suggests that the new peritoneal dialysis (PD) fluids may allow for better long-term preservation of peritoneal morphology and function. Formation of glucose degradation products (GDPs) can be reduced and even avoided with the use of newer "biocompatible" solutions. However, it is still unclear if there are any differences in using conventional (lactate) solutions compared with low GDP (bicarbonate) solutions for acute PD. To look at the benefits and harms of bicarbonate versus lactate solutions in acute PD. We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (from 1966), EMBASE (from 1980), Latin American and Caribbean Health Sciences Literature Database LILACS (from 1982), and reference lists of articles.Date of last search: 6 May 2014. Randomised controlled trials (RCTs) comparing bicarbonate to lactate solution for acute PD. Two authors independently assess the methodological quality of studies. One author abstracted data onto a standard form, and a second author checked data extraction. We used the random-effects model and expressed the results as relative risk (RR) for dichotomous outcomes and mean difference (MD) for continuous outcomes with 95% confidence intervals (CI). We included one study (20 patients) in this review. In shock patients, bicarbonate did not differ from lactate with respect to mortality (RR 0.50, 95% CI 0.06 to 3.91); however there were significant differences in blood lactate (MD -1.60 mmol/L, 95% CI -2.04 to -1.16), serum bicarbonate (MD 5.00 mmol/L, 95% CI 3.26 to 6.74) and blood pH (MD 0.12, 95% CI 0.06 to 0.18). In non-shock patients there was a significance difference in blood lactate (MD -0.60 mmol/L, 95% CI -0.85 to -0.35) but not in serum bicarbonate (MD 1.10 mmol/L, 95% CI -0.27 to 2.47) or blood pH (MD -0.02, 95% CI -0.02 to -0.06). Other outcomes could not be analysed because of the limited data available. There is no strong evidence that any clinical advantage for patients requiring acute PD for AKI when comparing conventional (lactate) with low GDP dialysis solutions (bicarbonate).

Probiotics for the Treatment of Atopic Dermatitis in Children: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

PubMed Central

Huang, Ruixue; Ning, Huacheng; Shen, Minxue; Li, Jie; Zhang, Jianglin; Chen, Xiang

2017-01-01

Objective: Atopic dermatitis (AD) is a prevalent, burdensome, and psychologically important pediatric concern. Probiotics have been suggested as a treatment for AD. Some reports have explored this topic; however, the utility of probiotics for AD remains to be firmly established. Methods: To assess the effects of probiotics on AD in children, the PubMed/Medline, Cochrane Library Scopus, and OVID databases were searched for reports published in the English language. Results: Thirteen studies were identified. Significantly higher SCORAD values favoring probiotics over controls were observed (mean difference [MD], −3.07; 95% confidence interval [CI], −6.12 to −0.03; P < 0.001). The reported efficacy of probiotics in children < 1 year old was −1.03 (95%CI, −7.05 to 4.99) and that in children 1–18 years old was −4.50 (95%CI, −7.45 to −1.54; P < 0.001). Subgroup analyses showed that in Europe, SCORAD revealed no effect of probiotics, whereas significantly lower SCORAD values were reported in Asia (MD, −5.39; 95%CI, −8.91 to −1.87). Lactobacillus rhamnosus GG (MD, 3.29; 95%CI, −0.30 to 6.88; P = 0.07) and Lactobacillus plantarum (MD, −0.70; 95%CI, −2.30 to 0.90; P = 0.39) showed no significant effect on SCORAD values in children with AD. However, Lactobacillus fermentum (MD, −11.42; 95%CI, −13.81 to −9.04), Lactobacillus salivarius (MD, −7.21; 95%CI, −9.63 to −4.78), and a mixture of different strains (MD, −3.52; 95%CI, −5.61 to −1.44) showed significant effects on SCORAD values in children with AD. Conclusions: Our meta-analysis indicated that the research to date has not robustly shown that probiotics are beneficial for children with AD. However, caution is needed when generalizing our results, as the populations evaluated were heterogeneous. Randomized controlled trials with larger samples and greater power are necessary to identify the species, dose, and treatment duration of probiotics that are most efficacious for treating AD in children. PMID:28932705

77 FR 27463 - Device Improvements for Pediatric X-Ray Imaging; Public Meeting; Request for Comments

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-10

... pediatric x-ray imaging that may benefit from standards development or further research. DATES: Date and... held at FDA White Oak Campus, 10903 New Hampshire Ave., Building 31 Conference Center, the Great Room..., Food and Drug Administration, 10903 New Hampshire Ave., Bldg. 66, rm. 4527, Silver Spring, MD 20993...

Comparison of outpatient and home-based exercise training programmes for COPD: A systematic review and meta-analysis.

PubMed

Wuytack, Francesca; Devane, Declan; Stovold, Elizabeth; McDonnell, Melissa; Casey, Michelle; McDonnell, Timothy J; Gillespie, Paddy; Raymakers, Adam; Lacasse, Yves; McCarthy, Bernard

2018-03-01

Chronic obstructive pulmonary disease is a common, preventable and treatable disease. Exercise training programmes (ETPs) improve symptoms, health-related quality of life (HRQoL) and exercise capacity, but the optimal setting is unknown. In this review, we compared the effects of ETPs in different settings on HRQoL and exercise capacity. We searched (5 July 2016) the Cochrane Airways Group Specialised Register, ClinicalTrials.gov and World Health Organization trials portal. We selected studies, extracted data and assessed risk of bias with two independent reviewers. We calculated mean differences (MD) with 95% CI. We assessed the quality of evidence using Grades of Recommendation, Assessment, Development and Evaluation. Ten trials (934 participants) were included. Hospital (outpatient) and home-based ETPs (seven trials) were equally effective at improving HRQoL on the Chronic Respiratory Questionnaire (CRQ) (dyspnoea: MD -0.09, 95% CI: -0.28 to 0.10; fatigue: MD -0.00, 95% CI: -0.18 to 0.17; emotional: MD 0.10, 95% CI: -0.24 to 0.45; and mastery: MD -0.02, 95% CI: -0.28 to 0.25; moderate quality) and on the St George's Respiratory Questionnaire (SGRQ) (MD -0.82, 95% CI: -7.47 to 5.83, low quality). Hospital (outpatient) and community-based ETPs (three trials) were equally effective at improving HRQoL (CRQ dyspnoea: MD 0.29, 95% CI: -0.05 to 0.62, moderate quality; fatigue: MD -0.02, 95% CI: -1.09 to 1.05, low quality; emotional: MD 0.10, 95% CI: -0.40 to 0.59, moderate quality; and mastery: MD -0.08, 95% CI: -0.45 to 0.28, moderate quality). There was no difference in exercise capacity. There was low to moderate evidence that outpatient and home-based ETPs are equally effective. See related Editorial. © 2017 Asian Pacific Society of Respirology.

75 FR 32955 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-10

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... applications. Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892 (Virtual Meeting... Institutes of Health, 6701 Rockledge Drive, Room 2200, MSC 7890, Bethesda, MD 20892, 301-435- 2514, stassid...

77 FR 6809 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-09

... 7770, Bethesda, MD 20892, 301 806-0009, [email protected]csr.nih.gov . Name of Committee: Healthcare..., Room 3166, MSC 7770, Bethesda, MD 20892, 301-254-9975, [email protected]csr.nih.gov . Name of Committee... Committee: Healthcare Delivery and Methodologies Integrated Review Group Community-Level Health Promotion...

78 FR 38065 - Office of the Director, National Institutes of Health; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-25

... Rockville Pike, Rockville, MD 20852. Contact Person: Barbara J. Nelson, Ph.D., Scientific Review Officer, Office of Grants Management and Scientific Review, National Center for Advancing Translational Sciences..., National Center for Advancing Translational Sciences, 6701 Democracy Blvd., Room 1078, Bethesda, MD 20892...

76 FR 38405 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-30

..., 6701 Rockledge Drive, Bethesda, MD 20892 (Virtual Meeting). Contact Person: Michael H Chaitin, PhD... (Virtual Meeting). Contact Person: David L Williams, PhD, Scientific Review Officer, Center for Scientific... Health, 6701 Rockledge Drive, Bethesda, MD 20817 (Virtual Meeting). Contact Person: David L Williams, PhD...

77 FR 35988 - National Institute of Dental and Craniofacial Research; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-15

... review and evaluate grant applications. Place: National Institutes of Health, One Democracy Plaza, 6701 Democracy Boulevard, Bethesda, MD 20892 (Telephone Conference Call). Contact Person: Victor Henriquez, PhD., Scientific Review Officer, DEA/SRB/NIDCR, 6701 Democracy Blvd., Room 668, Bethesda, MD 20892-4878, 301-451...

76 FR 28055 - National Institute of Biomedical Imaging and Bioengineering; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-13

... review and evaluate grant applications. Place: National Institutes of Health, Two Democracy Plaza, 6707 Democracy Boulevard, Bethesda, MD 20892. Contact Person: Ruixia Zhou, PhD, Scientific Review Officer, 6707 Democracy Boulevard, Democracy Two Building, Suite 957, Bethesda, MD 20892, 301-496-4773, [email protected

Retrospective review of adverse incidents involving passengers seated in wheeled mobility devices while traveling in large accessible transit vehicles.

PubMed

Frost, Karen L; Bertocci, Gina

2010-04-01

Characterize wheeled mobility device (WhMD) adverse incidents on large accessible transit vehicles (LATVs) based on vehicle motion, WhMD activity during incident, incident scenario and injury. Retrospective records review. WhMD passengers traveling on LATVs while remaining seated in their. Adverse incidents characterized based on vehicle motion, WhMD activity during incident, and incident scenario. Injury characterized based on outcome, medical attention sought, vehicle activity, WhMD activity and incident scenario. 115 WhMD-related incident reports for years 2000-2005 were analyzed. Most incidents occurred when the LATV was stopped (73.9%), during ingress/egress (42.6%), and at the securement station (33.9%) when the LATV was moving. The combination of WhMD tipping and passenger falling (43.4%) occurred most frequently, and was 1.8 times more likely to occur during ingress/egress than at the securement station. One-third (33.6%) of all incidents resulted in injury, and injuries were equally distributed between ingress/egress (43.6%) and at the securement station (43.6%). WhMD users have a greater chance of incurring injury during ingress/egress than during transit. Research is needed to objectively assess real world transportation experiences of WhMD passengers, and to assess the adequacy of existing federal legislation/guidelines for accessible ramps used in public transportation. Copyright 2009 IPEM. Published by Elsevier Ltd. All rights reserved.

Tables of Calculated Transition Probabilities for the A-X System of OH

DTIC Science & Technology

1981-06-01

June 1981 US ARMY ARMAMENT RESEARCH AND DEVELOPMENT COMMAND BALLISTIC RESEARCH LABORATORY ABERDEEN PROVING GROUND , MARYLAND Approved for public release...Laboratory ATTN: DRDAR-BLP Aberdeen Proving Ground , MD 21005 1L16112AH43 II. CONTROLLING OFFICE NAME AND ADDRESS 12. REPORT DATE USA Armament Research and...Development Command /I JUNE. 1981 USA Ballistic Research Laboratory 4 ATTN: DRDAR-BL 1/1) S 2P’GE Aberden Provine Ground . MD 21001 56 Pazes 14

Combination Immunotherapy for the Treatment of High-Risk HER2-Positive Breast Cancer

DTIC Science & Technology

2017-10-01

AWARD NUMBER: W81XWH-14-1-0109 TITLE: Combination Immunotherapy for the Treatment of High-Risk HER2-Positive Breast Cancer PRINCIPAL INVESTIGATOR...Elizabeth A. Mittendorf, MD, PhD CONTRACTING ORGANIZATION: University of Texas MD Anderson Cancer Center Houston, TX 77030 REPORT DATE: October...CONTRACT NUMBER Combination Immunotherapy for the Treatment of High-Risk HER2-Positive Breast Cancer 5b. GRANT NUMBER W81XWH-14-1-0109 5c. PROGRAM

HBCU Summer Undergraduate Training Program in Prostate Cancer: A Partnership Between USU-CPDR and UDC

DTIC Science & Technology

2017-10-01

Bethesda, MD 20817 REPORT DATE: October 2017 TYPE OF REPORT: Annual PREPARED FOR: U.S. Army Medical Research and Materiel Command Fort...AUTHOR(S) Shiv Srivastava, PhD; Taduru Sreenath, PhD; Center for Prostate Disease Research , Dept of Surgery, Uniformed Services University of the...Army Medical Research Materiel Command Fort Detrick, MD 21702-5012 10. SPONSOR/MONITOR’S ACRONYM(S) 11. SPONSOR/MONITOR’S REPORT NUMBER(S) 12

Will PEDF Therapy Reverse Chronic Demyelination and Prevent Axon Loss in a Murine Model of Progressive Multiple Sclerosis

DTIC Science & Technology

2015-12-01

Multiple Sclerosis ? PRINCIPAL INVESTIGATOR: David Pleasure MD CONTRACTING ORGANIZATION: University of California Davis, CA 95618 REPORT DATE...Murine Model of Progressive Multiple Sclerosis ? 5b. GRANT NUMBER W81XWH-12-1-0566 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) David Pleasure MD 5d...enhance central nervous system (CNS) remyelination and preserve CNS axons in mouse models of multiple sclerosis models. After determining the dosage of

Organtropic Metastatic Secretomes and Exosomes in Breast Cancer

DTIC Science & Technology

2016-10-01

MD, PhD CONTRACTING ORGANIZATION: Joan & Sanford I Weill Medical College of Cornell University New York, NY 10065 REPORT DATE: October 2016 TYPE...STATEMENT: Approved for Public Release; Distribution Unlimited The views, opinions and/or findings contained in this report are those of the author( s ) and...Cancer 5b. GRANT NUMBER N/A 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR( S ) 5d. PROJECT NUMBER David Lyden, MD, PhD, Ayuko Hoshino, PhD, Irina Matei, PhD

The relationship between anabolic androgenic steroids and muscle dysmorphia: a review.

PubMed

Rohman, Lebur

2009-01-01

This review explores the condition of muscle dysmorphia (MD) and its relationship with anabolic androgenic steroids (AAS). Particular emphasis is placed upon whether anabolic steroids are a predisposing, precipitating or perpetuating factor of MD. Furthermore, psychiatric complications of AAS abuse are examined. The current evidence from the literature suggests that AAS (ab)use is possibly a perpetuating factor in the evolution of MD. Psychiatric complications of AAS include mood and behavior changes, perceptual abnormalities, and withdrawal symptoms. In addition, there appears to be a credible dependence theory to AAS in fruition.

Arthroscopic management of posterior instability of the shoulder: A systematic review of predictive factors associated with poorer surgical outcomes.

PubMed

Jain, Sachin Ramesh; Sayampanathan, Andrew Arjun; Hwee Chye Tan, Andrew

2017-01-01

We aimed to perform a systematic review to identify factors that may lead to poorer outcomes in arthroscopic surgery for posterior shoulder instability. We searched MEDLINE, Embase and the Cochrane Database of Systematic Reviews for 757 unique articles. We eventually included 22 articles. Data were analysed using Review Manager 5.3. The presence of chondral damage was associated with poorer outcomes as reflected in a higher post-operative Quick Disabilities of theArm, Shoulder and Hand score (mean difference (MD) = 17.1; 95% confidence interval (CI) = 2.82-31.4; p = 0.02), higher WesternOntario Shoulder Instability (WOSI) index (MD = 468.0; 95% CI = 136.5-799.5; p = 0.006), lower Simple Shoulder Test score (MD = -2.40; 95% CI = -4.34 to -0.46; p = 0.02) and a lower Single Assessment Numeric Evaluation score (MD = -15.4; 95% CI = -30.6 to -0.23; p = 0.05). The presence of previous shoulder surgery was associated with poorer outcomes as depicted by a lower American Shoulder and Elbow Society (ASES) score (MD = -93.1; 95% CI = -96.9 to -89.3; p < 0.0001). The availability of workers' compensation was associated with poorer outcomes as revealed by a lower rate of return to work (odds ratio (OR) = 0.02; 95% CI = 0.00-0.20; p = 0.0008). The presence of additional procedures while performing surgery for posterior shoulder instability was associated with poorer outcomes as reflected by lower ASES scores (MD = -6.70; 95% CI = -8.64 to -4.76; p < 0.0001), higher WOSI index (MD = 63.4; 95% CI = 33.0-93.8; p < 0.0001), lower University of California at Los Angeles (UCLA) scores (MD = -2.30; 95% CI = -2.81 to -1.79; p < 0.0001), higher pain scores (MD = 0.72; 95% CI = 0.39-1.05; p < 0.0001) and higher post-operative instability (MD = 0.80; 95% CI = 0.57-1.03; p < 0.0001). The presence of chondral damage, previous shoulder surgery, concomitant surgery and workman's compensation was associated with poorer outcomes for arthroscopic repair of posterior shoulder instability. Further studies should be done to further validate these factors.

The Marine Corps Martial Arts Program: Sustaining the Transformation

DTIC Science & Technology

2002-04-01

Approved: _______________ Date: _______________ Mentor: Colonel Robert P. Wagner, USMC Approved: _______________ Date: _______________ REPORT... Robert Debs Heinl Jr., USMC (Ret.), Soldiers of the Sea (Annapolis, MD: United States Naval Institute, 1962), 603. 7 constituency of the force, as well...changes over decades, the Marine Corps has shown the ability to adapt its training to meet those conditions. As Colonel Robert Wagner noted, over time

Computer Implementation of a Muzzle Blast Prediction Technique

DTIC Science & Technology

1985-05-01

AVERDEEN PROVING GROUND , MARYLAND • 1y 4 4q* Destroy this report when it is no longer needed. Do not return it to the originator. Additional copies of this...Laboratory AREA & WORK UNIT NUMBERS ATTN: APXBR-LFD Aberdeevi Proving Ground , MD 21005-5066 RDT&E 1LI61102AH43 Ii. CONTROLLING OFFICE NAME AND ADDRESS 12...REPORT DATE !I.S. Army Ballistic Research Laboratory May 1985 ATTN: AMXBR-OD-ST 13. NUMBER OF PAGES Aberdeen Proving Ground , MD. 21005-5066 . 89 14

Surface Layer Effects on the Mechanical Behavior of Metals.

DTIC Science & Technology

1984-05-01

D-A142 280 SURFACE LAYER EFFECT ON THE MECHANICAL BEHAVIOR OF / IETALS(U) DAVID W TAYLOR NAVAL SHIP RESEARCH AND DEVELOPMENT CENTER BETHESDA MD I R...MICROCOPY RESOLUTION TEST CHART 14A T 104AL BU*r.AU O STAP,49S43- DAVID W. TAYLOR NAVALISHIP RESEARCH AND DEVELOPMENT CENTER * k Bethesda, Maryland...2802-014 II. CONTROLLING OFFICE NAME AND ADDRESS 12. REPORT DATE David W. Taylor Naval Ship R&D Center May 1984 Annapolis, MD 21402 13. NUMBER OF PAGES

The Influence of Psychological Factors in Meniere's Disease

PubMed Central

Orji, FT

2014-01-01

Many physicians have observed that psychological factors play a significant role in the course of Meniere's disease (MD), with Meniere's patients being subject to anxiety and tension states. A lot of research attentions from a psychological point of view have been directed at MD, with earlier researchers focusing on psychosomatic causes of the illness as well as its somatopsychic result. However, the question whether MD is caused by psychological factors or whether the psychological manifestation in MD is as a result of the illness is still unresolved. The aim of this study is to provide an overview of interaction that exists between physical and emotional factors in the development of MD and its impact on the quality of life of the sufferers. A structured literature search was carried out, with no restrictions to the dates searched. A vicious circle of interaction seems to exist between the somatic organic symptoms of MD and resultant psychological stress. The frightening attacks of vertigo seem likely to produce and increase the level of anxiety thereby worsening the emotional state and the resultant anxiety provokes various symptoms probably through disorders of the autonomic nervous system occasioned by the increased levels of stress-related hormones. PMID:24669323

Vasectomy

MedlinePlus

... a man's ability to have an erection or orgasm, or to ejaculate semen. A vasectomy does NOT ... Miller, MD, urologist in private practice in Atlanta, GA. Also reviewed by David Zieve, MD, MHA, Isla ...

76 FR 78672 - National Institute on Drug Abuse; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-19

..., Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852 (Telephone Conference Call). Contact Person... Addiction Research Programs, National Institutes of Health, HHS) Dated: December 13, 2011. Jennifer S...

76 FR 7571 - National Institute on Drug Abuse; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-10

..., Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852, (Telephone Conference Call). Contact Person....: 93.279, Drug Abuse and Addiction Research Programs, National Institutes of Health, HHS) Dated...

Ethnic and Environmental Influence on Vitamin D Requirement in Military Personnel

DTIC Science & Technology

2005-10-01

Robert P. Heaney, M.D. CONTRACTING ORGANIZATION: Creighton University Omaha, NE 68178 REPORT DATE: October 2005 TYPE OF REPORT: Annual PREPARED FOR: U.S...YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE (DD-MM-YYYY) 2. REPORT TYPE 3. DATES COVERED (From - To) 01-10-2005 Annual 1 Oct 2004 - 30 Sep 2005 4...amount of vitamin D that must be given orally to military personnel of different races and in different assigned locations so as to ensure and maintain

Tranexamic Acid for Trauma Patients: A Critical Review of the Literature

DTIC Science & Technology

2011-07-01

REVIEW ARTICLE Tranexamic Acid for Trauma Patients: A Critical Review of the Literature Andrew P. Cap, MD, PhD, David G. Baer, PhD, Jean A. Orman...MPH, ScD, James Aden, PhD, Kathy Ryan, PhD, and Lorne H. Blackbourne, MD Background: Tranexamic acid (TXA) is an antifibrinolytic that inhibits both...prospective clinical evidence to support this application. Key Words: Tranexamic acid , Antifibrinolytic agents, Hemorrhage/drug therapy, Wounds and injuries

Maternal depression and infant development: theory and current evidence.

PubMed

Miklush, Lisa; Connelly, Cynthia D

2013-01-01

Maternal depression (MD) is a condition that has wide-ranging effects on the woman, her family, and the broader global society. It is generally agreed that MD is associated with untoward effects on the developmental trajectory of offspring. The aim of this article is to review the historical and theoretical underpinnings informing current thought linking MD with infant development, and to highlight some of the neuroendocrine and epigenetic processes related to MD and its sequelae. A broad understanding of the association between MD and infant developmental outcomes can inform nursing care of the childbearing family.

77 FR 39714 - National Cancer Institute; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-05

..., MD 20814. Contact Person: Gail J. Bryant, MD, Medical Officer, Resources and Training Review Branch..., Cancer Detection and Diagnosis Research; 93.395, Cancer Treatment Research; 93.396, Cancer Biology...

Logistics | Division of Cancer Prevention

Cancer.gov

Date and Time Registration will begin at 8:30 am on Friday, September 20th. The meeting will begin promptly at 9:00 am. Location NIH Campus Natcher Conference Center Building 45 45 Center Drive Bethesda, MD |

78 FR 45252 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-26

... 7852, Bethesda, MD 20892, 301-435- 1775, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle... Health, 6701 Rockledge Drive, Room 3130, MSC 7850, Bethesda, MD 20892, 301-435-3009, [email protected]csr.nih.gov...

Probiotics, prebiotics infant formula use in preterm or low birth weight infants: a systematic review

PubMed Central

2012-01-01

Background Previous reviews (2005 to 2009) on preterm infants given probiotics or prebiotics with breast milk or mixed feeds focused on prevention of Necrotizing Enterocolitis, sepsis and diarrhea. This review assessed if probiotics, prebiotics led to improved growth and clinical outcomes in formula fed preterm infants. Methods Cochrane methodology was followed using randomized controlled trials (RCTs) which compared preterm formula containing probiotic(s) or prebiotic(s) to conventional preterm formula in preterm infants. The mean difference (MD) and corresponding 95% confidence intervals (CI) were reported for continuous outcomes, risk ratio (RR) and corresponding 95% CI for dichotomous outcomes. Heterogeneity was assessed by visual inspection of forest plots and a chi2 test. An I2 test assessed inconsistencies across studies. I2> 50% represented substantial heterogeneity. Results Four probiotics studies (N=212), 4 prebiotics studies (N=126) were included. Probiotics: There were no significant differences in weight gain (MD 1.96, 95% CI: -2.64 to 6.56, 2 studies, n=34) or in maximal enteral feed (MD 35.20, 95% CI: -7.61 to 78.02, 2 studies, n=34), number of stools per day increased significantly in probiotic group (MD 1.60, 95% CI: 1.20 to 2.00, 1 study, n=20). Prebiotics: Galacto-oligosaccharide / Fructo-oligosaccharide (GOS/FOS) yielded no significant difference in weight gain (MD 0.04, 95% CI: -2.65 to 2.73, 2 studies, n=50), GOS/FOS yielded no significant differences in length gain (MD 0.01, 95% CI: -0.03 to 0.04, 2 studies, n=50). There were no significant differences in head growth (MD −0.01, 95% CI: -0.02 to 0.00, 2 studies, n=76) or age at full enteral feed (MD −0.79, 95% CI: -2.20 to 0.61, 2 studies, n=86). Stool frequency increased significantly in prebiotic group (MD 0.80, 95% CI: 0.48 to 1.1, 2 studies, n=86). GOS/FOS and FOS yielded higher bifidobacteria counts in prebiotics group (MD 2.10, 95% CI: 0.96 to 3.24, n=27) and (MD 0.48, 95% CI: 0.28 to 0.68, n=56). Conclusions There is not enough evidence to state that supplementation with probiotics or prebiotics results in improved growth and clinical outcomes in exclusively formula fed preterm infants. PMID:22928998

Mechanism of the G-protein mimetic nanobody binding to a muscarinic G-protein-coupled receptor.

PubMed

Miao, Yinglong; McCammon, J Andrew

2018-03-20

Protein-protein binding is key in cellular signaling processes. Molecular dynamics (MD) simulations of protein-protein binding, however, are challenging due to limited timescales. In particular, binding of the medically important G-protein-coupled receptors (GPCRs) with intracellular signaling proteins has not been simulated with MD to date. Here, we report a successful simulation of the binding of a G-protein mimetic nanobody to the M 2 muscarinic GPCR using the robust Gaussian accelerated MD (GaMD) method. Through long-timescale GaMD simulations over 4,500 ns, the nanobody was observed to bind the receptor intracellular G-protein-coupling site, with a minimum rmsd of 2.48 Å in the nanobody core domain compared with the X-ray structure. Binding of the nanobody allosterically closed the orthosteric ligand-binding pocket, being consistent with the recent experimental finding. In the absence of nanobody binding, the receptor orthosteric pocket sampled open and fully open conformations. The GaMD simulations revealed two low-energy intermediate states during nanobody binding to the M 2 receptor. The flexible receptor intracellular loops contribute remarkable electrostatic, polar, and hydrophobic residue interactions in recognition and binding of the nanobody. These simulations provided important insights into the mechanism of GPCR-nanobody binding and demonstrated the applicability of GaMD in modeling dynamic protein-protein interactions.

75 FR 25277 - National Institute on Drug Abuse; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-07

... applications. Place: National Institutes of Health, 6101 Executive Boulevard, Rockville, MD 20852 (Virtual..., Rockville, MD 20852 (Virtual Meeting). Contact Person: Gerald L. McLaughlin, PhD, Scientific Review...

Impact of Early Enteral Nutrition on Nutritional and Immunological Outcomes of Gastric Cancer Patients Undergoing Gastrostomy: A Systematic Review and Meta-Analysis.

PubMed

Nikniaz, Zeinab; Somi, Mohammad Hossein; Nagashi, Shahnaz; Nikniaz, Leila

2017-07-01

The present systematic review and meta-analysis study evaluated the impact of early enteral nutrition (EN) on postoperative nutritional and immunological outcomes of gastric cancer (GC) patients. The databases of PubMed, Embase, Springer, and Cochrane library were searched till September 2016 to identify studies which evaluated the effects of EN compared with parenteral nutrition (PN) on postoperative immunological and nutritional status and hospitalization time in GC patients. Mean difference (MD) or standard mean difference (SMD) was calculated and I-square statistic test was used for heterogeneity analysis. The present systematic review and meta-analysis have consisted of seven trials, containing 835 GC patients. According to the result of meta-analysis, compared with PN, EN significantly resulted in more increase in the level of albumin [MD = 2.07 (0.49, 3.64)], prealbumin [MD = 9.41 (049, 33.55)], weight [MD = 1.52 (0.32, 2.72)], CD3+ [SMD = 1.96 (1.50, 2.43)], CD4+ [SMD = 2.45 (1.97, 2.93)], natural killers [MD = 5.80 (3.75, 7.85)], and also a decrease in the hospitalization time [MD=-2.39 (-2.74, -2.03)]. The results demonstrated that early administration of EN is more effective in improving postsurgical nutrition status and immune index in GC patients. So, based on these results, postoperative early administration of EN is recommended for GC patients where possible.

Interventions for unilateral and bilateral refractive amblyopia.

PubMed

Taylor, Kate; Powell, Christine; Hatt, Sarah R; Stewart, Catherine

2012-04-18

Refractive amblyopia is a common cause of reduced visual acuity in childhood, but optimal treatment is not well defined. This review examined the treatment effect from spectacles and conventional occlusion. Evaluation of the evidence of the effectiveness of spectacles, occlusion or both in the treatment of unilateral and bilateral refractive amblyopia. We searched CENTRAL (which contains the Cochrane Eyes and Vision Group Trials Register) (The Cochrane Library 2012, Issue 1), MEDLINE (January 1950 to January 2012), EMBASE (January 1980 to January 2012), Latin American and Caribbean Health Sciences Literature Database (LILACS) (January 1982 to January 2012), the metaRegister of Controlled Trials (mRCT) (www.controlled-trials.com), ClinicalTrials.gov (www.clinicaltrials.gov) and the WHO International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en). There were no date or language restrictions in the electronic searches for trials. We last searched the electronic databases on 24 January 2012. We manually searched relevant conference proceedings. Randomised controlled trials of treatment for unilateral and bilateral refractive amblyopia by spectacles, with or without occlusion, were eligible. We included studies with participants of any age. Two authors independently assessed abstracts identified by the searches. We obtained full-text copies and contacted study authors where necessary. Eleven trials were eligible for inclusion. We extracted data from eight. Insufficient data were present for the remaining three trials so data extraction was not possible. We identified no trials as containing participants with bilateral amblyopia. We performed no meta-analysis as there were insufficient trials for each outcome. For all studies mean acuity (standard deviation (SD)) in the amblyopic eye post-treatment was reported. All included trials reported treatment for unilateral refractive amblyopia.One study randomised participants to spectacles only compared to no treatment, spectacles plus occlusion compared to no treatment and spectacles plus occlusion versus spectacles only. For spectacles only versus no treatment, mean (SD) visual acuity was: spectacles group 0.31 (0.17); no treatment group 0.42 (0.19) and mean difference (MD) between groups was -0.11 (borderline statistical significance: 95% confidence interval (CI) -0.22 to 0.00). For spectacles plus occlusion versus no treatment, mean (SD) visual acuity was: full treatment 0.22 (0.13); no treatment 0.42 (0.19). Mean difference (MD) between the groups -0.20 (statistically significant: 95% CI -0.30 to -0.10). For spectacles plus occlusion versus spectacles only, MD was -0.09 (borderline statistical significance 95% CI -0.18 to 0.00). For two other trials that also looked at this comparison MD was -0.15 (not statistically significant 95% CI -0.32 to 0.02) for one trial and MD 0.01 (not statistically significant 95% CI -0.08 to 0.10) for the second trial.Three trials reviewed occlusion regimes.One trial looked at two hours versus six hours for moderate amblyopia: MD 0.01 (not statistically significant: 95% CI -0.06 to 0.08); a second trial 2003b reviewed six hours versus full-time for severe amblyopia: MD 0.03 (not statistically significant: 95% CI -0.08 to 0.14) and a third trial looked at six hours versus full-time occlusion: MD -0.12 (not statistically significant: 95% CI -0.27 to 0.03). One trial looked at occlusion supplemented with near or distance activities: MD-0.03 (not statistically significant 95% CI -0.09 to 0.03). One trial looked at partial occlusion and glasses versus glasses only: MD -0.01 (not statistically significant: 95% CI -0.05 to 0.03). In some cases of unilateral refractive amblyopia it appears that there is a treatment benefit from refractive correction alone. Where amblyopia persists there is evidence that adding occlusion further improves vision. Despite advances in the understanding of the treatment of amblyopia it is currently still not possible to tailor individual treatment plans for amblyopia. The nature of any dose/response effect from occlusion still needs to be clarified. Partial occlusion appears to have the same treatment effect as glasses alone when started simultaneously for the treatment of unilateral refractive amblyopia. Treatment regimes for bilateral and unilateral refractive amblyopia need to be investigated further.

Down-staging (

PubMed

Beukers, Willemien; Meijer, Titia; Vissers, Cornelis J; Boormans, Joost L; Zwarthoff, Ellen C; van Leenders, Geert J L H

2012-08-01

Urothelial cell carcinoma (UCC) with musculus detrusor (MD) invasion is treated by cystectomy. Subsequent pathologic evaluation of cystectomies does not reveal MD invasion (

Interventions for unilateral refractive amblyopia.

PubMed

Shotton, Kate; Powell, Christine; Voros, Gerasimos; Hatt, Sarah R

2008-10-08

Unilateral refractive amblyopia is a common cause of reduced visual acuity in childhood, but optimal treatment is not well defined. This review examined the treatment effect from spectacles and conventional occlusion. Evaluation of the evidence of the effectiveness of spectacles and or occlusion in the treatment of unilateral refractive amblyopia. We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE and LILACS. Relevant conference proceedings were manually searched. There were no date or language restrictions. The searches were last run on 7 July 2008. Randomised controlled trials of treatment for unilateral refractive amblyopia by spectacles, with or without occlusion were eligible. We included studies with participants of any age. Two authors independently assessed abstracts identified by the searches. We obtained full text copies and contacted study authors where necessary. Eight trials were eligible for inclusion. Data were extracted from seven. No meta-analysis was performed. For all studies mean acuity (standard deviation (SD)) in the amblyopic eye post treatment is reported.Comparison: Spectacles only versus no treatment (Clarke 2003). Mean (SD) visual acuity: spectacles group 0.31 (0.17); no treatment group 0.42 (0.19). Mean difference (MD) between groups -0.11 (borderline statistical significance: 95% confidence interval (CI) -0.22 to 0.00).Comparison: Spectacles plus occlusion versus no treatment (Clarke 2003). Mean (SD) visual acuity: full treatment 0.22 (0.13); no treatment 0.42 (0.19). Mean difference between the groups -0.20 (statistically significant: 95% CI -0.30 to -0.10).Comparison: Spectacles plus occlusion versus spectacles only: Clarke 2003 MD -0.09 (borderline statistical significance 95% CI, -0.18 to 0.00); PEDIG 2005b; MD -0.15 (not statistically significant 95% CI -0.32 to 0.02); PEDIG 2006a; MD 0.01 (not statistically significant 95% CI -0.08 to 0.10).Comparison: Occlusion regimes. PEDIG 2003a: 2 hours versus 6 hours for moderate amblyopia: MD 0.01 (not statistically significant: 95% CI -0.06 to 0.08); PEDIG 2003b: 6 hours versus full-time for severe amblyopia: MD 0.03 (not statistically significant: 95% CI -0.08 to 0.14). Stewart 2007a: 6 hours versus full-time occlusion: MD -0.12 (not statistically significant: 95% CI -0.27 to 0.03) In some cases of unilateral refractive amblyopia it appears that there is a treatment benefit from refractive correction alone. Where amblyopia persists there is some evidence that adding occlusion further improves vision. It remains unclear which treatment regimes are optimal for individual patients. The nature of any dose/response effect from occlusion still needs to be clarified.

Clinical Study of Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) for Severe Pelvic Fracture and Intra-Abdominal Hemorrhagic Shock Using Continuous Vital Signs

DTIC Science & Technology

2017-03-01

University of Maryland, Baltimore Baltimore, MD 21201 REPORT DATE: March 2017 TYPE OF REPORT: Annual PREPARED FOR: U.S. Army Medical Research ...ongoing. After FDA approval of a new novel REBOA catheter (ER-REBOATM (Prytime Medical , Boerne, TX )) in October 2015, we incorporated this catheter into...Scalea, MD 39th Annual CONFERENCE ON SHOCK – June 11-14th, Austin , TX 2. REBOA IMPROVES MEAN BLOOD PRESSURE (MBP) AND SHOCK INDEX (SI) AS MEASURED

Commentary on: Muscle dysmorphia: Could it be classified as an addiction to body image?

PubMed Central

2015-01-01

Background The article titled ‘Muscle dysmorphia: Could it be classified as an addiction to body image?’ used Griffiths (2005) addiction components model as the framework in which to define muscle dysmorphia (MD) as an addiction. The authors (Foster, Shorter & Griffiths, 2014) proposed that MD could be re-classified as an addiction to body image. Method and aim In response to the original article, the author of this commentary reflected on the ‘Addiction to body image’ model and the components of addiction as described in the context of MD. This invited commentary aimed to provide opposing viewpoints in order to give a balanced overview on the topic. Results It appears as if the components of addictions can be used as a framework in which to define MD. However, systematic empirical evidence had not been provided for the withdrawal symptoms associated with this behavioral addiction. An opposing viewpoint is provided in response to Foster et al.’s (2014) statement that MD is different from other body dysmorphic disorders in regards to cognitive dysfunction, and therefore cannot be explained in the same way. Conclusions Based on the little systematic empirical evidence to date, it may be a bit premature to re-classify MD as an addiction to body image. PMID:25592217

MANAGEMENT OF ENDOCRINE DISEASE: The impact of subclinical hypothyroidism on anthropometric characteristics, lipid, glucose and hormonal profile of PCOS patients: a systematic review and meta-analysis.

PubMed

Pergialiotis, Vasilios; Konstantopoulos, Panagiotis; Prodromidou, Anastasia; Florou, Venetia; Papantoniou, Nikolaos; Perrea, Despina N

2017-03-01

Subclinical hypothyroidism (SCH) is encountered in 10-25% of women with PCOS. To date, it remains unclear whether this coexistence influences the severity of metabolic and hormonal profile of these patients. The purpose of our systematic review is to investigate this potential relation. We systematically searched Medline, Scopus, ClinicalTrials.gov, Cochrane Central Register of Controlled Trials (CENTRAL) and Google Scholar databases together with reference lists from included studies. All prospective and retrospective observational cohort studies that investigated the impact of subclinical hypothyroidism on hormonal and metabolic parameters of PCOS patients were included. The methodological quality of studies was assessed with the Ottawa-Newcastle criteria. Statistical meta-analysis was performed with the RevMan 5.3 software. Twelve studies were finally included in the present review, which enrolled 2341 PCOS patients. Among them, 577 had subclinical hypothyroidism, whereas the remaining 2077 were PCOS women with normal thyroid function. The presence of SCH significantly affected HDL (MD -3.92 mg/dL 95% CI: -6.56, -1.29) and triglycerides levels (26.91 mg/dL 95% CI: -3.79, 50.02). HOMA-IR was also affected (MD 0.82 95% CI: 0.15, 1.50). On the other hand, LDL, fasting glucose and 2-h OGTT were not influenced. Similarly, prolactin, FSH, LH, LH/FSH ratio and sex hormone-binding globulin remained unaffected. Subclinical hypothyroidism does not influence the hormonal profile of women with PCOS. On the other hand, it results in mild metabolic abnormalities, which are not clinically important in a short-term setting. © 2017 European Society of Endocrinology.

Ada Compiler Validation Summary Report: Certificate Number 891201S1. 10213 U.S. Navy Ada/M Version 2.0 (/NO Optimize Option) VAX 8550 and VAX 11/785 Hosts and AN/UYK-44 Target

DTIC Science & Technology

1989-12-01

T~IC F LE COK _"_ "NTATION PAGE I r070O18- AD-A223 693 M w-__wow_=ORT DATE ILREPORT TYP ND DATES CM RID I Dec 89 to I Dec 90 Final 4.1LE frMlTWLE...target), 891201.10213 LAVUTORS) National Institute of Standards and Technology Gaithersburg, MD USA 7 . PEWOOMWOPAA AT HW M S) L PEVodM ORGANIZATION 7 ...DATE VSR CCLPIETED BEFORE CN-SITE: 08-11-89 DATE VSR CPEIED AFE ON-SITE: 12-04-89 DATE VSR MODIFIED PER AVO CCMKENTS: 12-29-89 DATE VSR MODIFIED PER AVO

76 FR 27652 - Fogarty International Center; Amended Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-12

... International House, Bethesda, MD 20892 which was published in the Federal Register on April 4, 2011, 76 FR... the Lawton Chiles International House. The meeting is partially closed to the public. Dated: May 6...

75 FR 9910 - National Center for Research Resources; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-04

... applications. Place: 6701 Democracy Blvd., Democracy 1, 1082, Bethesda, MD (Virtual Meeting). Contact Person... Research Resources, Office of Review, 6701 Democracy Blvd, Rm. 1082, Bethesda, MD 20892, 301-435-0811...

Pilates for low back pain.

PubMed

Yamato, Tiê P; Maher, Christopher G; Saragiotto, Bruno T; Hancock, Mark J; Ostelo, Raymond W J G; Cabral, Cristina M N; Costa, Luciola C Menezes; Costa, Leonardo O P

2016-01-01

Non-specific low back pain is a major health problem worldwide. Interventions based on exercises have been the most commonly used treatments for patients with this condition. Over the past few years, the Pilates method has been one of the most popular exercise programmes used in clinical practice. To determine the effects of the Pilates method for patients with non-specific acute, subacute or chronic low back pain. We conducted the searches in CENTRAL, MEDLINE, EMBASE, CINAHL, PEDro and SPORTDiscus from the date of their inception to March 2014. We updated the search in June 2015 but these results have not yet been incorporated. We also searched the reference lists of eligible papers as well as six trial registry websites. We placed no limitations on language or date of publication. We only included randomized controlled trials that examined the effectiveness of Pilates intervention in adults with acute, subacute or chronic non-specific low back pain. The primary outcomes considered were pain, disability, global impression of recovery and quality of life. Two independent raters performed the assessment of risk of bias in the included studies using the 'Risk of bias' assessment tool recommended by The Cochrane Collaboration. We also assessed clinical relevance by scoring five questions related to this domain as 'yes', 'no' or 'unclear'. We evaluated the overall quality of evidence using the GRADE approach and for effect sizes we used three levels: small (mean difference (MD) < 10% of the scale), medium (MD 10% to 20% of the scale) or large (MD > 20% of the scale). We converted outcome measures to a common 0 to 100 scale when different scales were used. The search retrieved 126 trials; 10 fulfilled the inclusion criteria and we included them in the review (a total sample of 510 participants). Seven studies were considered to have low risk of bias, and three were considered as high risk of bias.A total of six trials compared Pilates to minimal intervention. There is low quality evidence that Pilates reduces pain compared with minimal intervention, with a medium effect size at short-term follow-up (less than three months after randomization) (MD -14.05, 95% confidence interval (CI) -18.91 to -9.19). For intermediate-term follow-up (at least three months but less than 12 months after randomization), two trials provided moderate quality evidence that Pilates reduces pain compared to minimal intervention, with a medium effect size (MD -10.54, 95% CI -18.46 to -2.62). Based on five trials, there is low quality evidence that Pilates improves disability compared with minimal intervention, with a small effect size at short-term follow-up (MD -7.95, 95% CI -13.23 to -2.67), and moderate quality evidence for an intermediate-term effect with a medium effect size (MD -11.17, 95% CI -18.41 to -3.92). Based on one trial and low quality evidence, a significant short-term effect with a small effect size was reported for function (MD 1.10, 95% CI 0.23 to 1.97) and global impression of recovery (MD 1.50, 95% CI 0.70 to 2.30), but not at intermediate-term follow-up for either outcome.Four trials compared Pilates to other exercises. For the outcome pain, we presented the results as a narrative synthesis due to the high level of heterogeneity. At short-term follow-up, based on low quality evidence, two trials demonstrated a significant effect in favour of Pilates and one trial did not find a significant difference. At intermediate-term follow-up, based on low quality evidence, one trial reported a significant effect in favour of Pilates, and one trial reported a non-significant difference for this comparison. For disability, there is moderate quality evidence that there is no significant difference between Pilates and other exercise either in the short term (MD -3.29, 95% CI -6.82 to 0.24) or in the intermediate term (MD -0.91, 95% CI -5.02 to 3.20) based on two studies for each comparison. Based on low quality evidence and one trial, there was no significant difference in function between Pilates and other exercises at short-term follow-up (MD 0.10, 95% CI -2.44 to 2.64), but there was a significant effect in favour of other exercises for intermediate-term function, with a small effect size (MD -3.60, 95% CI -7.00 to -0.20). Global impression of recovery was not assessed in this comparison and none of the trials included quality of life outcomes. Two trials assessed adverse events in this review, one did not find any adverse events, and another reported minor events. We did not find any high quality evidence for any of the treatment comparisons, outcomes or follow-up periods investigated. However, there is low to moderate quality evidence that Pilates is more effective than minimal intervention for pain and disability. When Pilates was compared with other exercises we found a small effect for function at intermediate-term follow-up. Thus, while there is some evidence for the effectiveness of Pilates for low back pain, there is no conclusive evidence that it is superior to other forms of exercises. The decision to use Pilates for low back pain may be based on the patient's or care provider's preferences, and costs.

Pilates for low back pain.

PubMed

Yamato, Tiê P; Maher, Christopher G; Saragiotto, Bruno T; Hancock, Mark J; Ostelo, Raymond W J G; Cabral, Cristina M N; Menezes Costa, Luciola C; Costa, Leonardo O P

2015-07-02

Non-specific low back pain is a major health problem worldwide. Interventions based on exercises have been the most commonly used treatments for patients with this condition. Over the past few years, the Pilates method has been one of the most popular exercise programmes used in clinical practice. To determine the effects of the Pilates method for patients with non-specific acute, subacute or chronic low back pain. We conducted the searches in CENTRAL, MEDLINE, EMBASE, CINAHL, PEDro and SPORTDiscus from the date of their inception to March 2014. We updated the search in June 2015 but these results have not yet been incorporated. We also searched the reference lists of eligible papers as well as six trial registry websites. We placed no limitations on language or date of publication. We only included randomised controlled trials that examined the effectiveness of Pilates intervention in adults with acute, subacute or chronic non-specific low back pain. The primary outcomes considered were pain, disability, global impression of recovery and quality of life. Two independent raters performed the assessment of risk of bias in the included studies using the 'Risk of bias' assessment tool recommended by The Cochrane Collaboration. We also assessed clinical relevance by scoring five questions related to this domain as 'yes', 'no' or 'unclear'. We evaluated the overall quality of evidence using the GRADE approach and for effect sizes we used three levels: small (mean difference (MD) < 10% of the scale), medium (MD 10% to 20% of the scale) or large (MD > 20% of the scale). We converted outcome measures to a common 0 to 100 scale when different scales were used. The search retrieved 126 trials; 10 fulfilled the inclusion criteria and we included them in the review (a total sample of 510 participants). Seven studies were considered to have low risk of bias, and three were considered as high risk of bias.A total of six trials compared Pilates to minimal intervention. There is low quality evidence that Pilates reduces pain compared with minimal intervention, with a medium effect size at short-term follow-up (less than three months after randomisation) (MD -14.05, 95% confidence interval (CI) -18.91 to -9.19). For intermediate-term follow-up (at least three months but less than 12 months after randomisation), two trials provided moderate quality evidence that Pilates reduces pain compared to minimal intervention, with a medium effect size (MD -10.54, 95% CI -18.46 to -2.62). Based on five trials, there is low quality evidence that Pilates improves disability compared with minimal intervention, with a small effect size at short-term follow-up (MD -7.95, 95% CI -13.23 to -2.67), and moderate quality evidence for an intermediate-term effect with a medium effect size (MD -11.17, 95% CI -18.41 to -3.92). Based on one trial and low quality evidence, a significant short-term effect with a small effect size was reported for function (MD 1.10, 95% CI 0.23 to 1.97) and global impression of recovery (MD 1.50, 95% CI 0.70 to 2.30), but not at intermediate-term follow-up for either outcome.Four trials compared Pilates to other exercises. For the outcome pain, we presented the results as a narrative synthesis due to the high level of heterogeneity. At short-term follow-up, based on low quality evidence, two trials demonstrated a significant effect in favour of Pilates and one trial did not find a significant difference. At intermediate-term follow-up, based on low quality evidence, one trial reported a significant effect in favour of Pilates, and one trial reported a non-significant difference for this comparison. For disability, there is moderate quality evidence that there is no significant difference between Pilates and other exercise either in the short term (MD -3.29, 95% CI -6.82 to 0.24) or in the intermediate term (MD -0.91, 95% CI -5.02 to 3.20) based on two studies for each comparison. Based on low quality evidence and one trial, there was no significant difference in function between Pilates and other exercises at short-term follow-up (MD 0.10, 95% CI -2.44 to 2.64), but there was a significant effect in favour of other exercises for intermediate-term function, with a small effect size (MD -3.60, 95% CI -7.00 to -0.20). Global impression of recovery was not assessed in this comparison and none of the trials included quality of life outcomes. Two trials assessed adverse events in this review, one did not find any adverse events, and another reported minor events. We did not find any high quality evidence for any of the treatment comparisons, outcomes or follow-up periods investigated. However, there is low to moderate quality evidence that Pilates is more effective than minimal intervention for pain and disability. When Pilates was compared with other exercises we found a small effect for function at intermediate-term follow-up. Thus, while there is some evidence for the effectiveness of Pilates for low back pain, there is no conclusive evidence that it is superior to other forms of exercises. The decision to use Pilates for low back pain may be based on the patient's or care provider's preferences, and costs.

Annual Research Progress Report, Fiscal Year 1981,

DTIC Science & Technology

1981-10-01

Joseph P. Murgo, M.D., COL, MC Key Words: Patent ductus arteriosus Cyanotic congenital heart disease Accumulative MEDCASE Est Accumulative Periodic Cost... Ductus Arteriosus in Neonates 47 with Cyanotic Congenital Heart Disease. (T) C-37-79 Ankle Trauma Study. (0) 48 C-5-80 Lopressor Intervention Trial. (0...Maintenance of Patency of the Ductus Arteriosus in Neonates with Cyanotic Congenital Heart Disease Start Date: Aug 79 Est Comp Date: Principal

A Phase II Trial on the Effect of Low-Dose versus High-Dose Vitamin D Supplementation on Bone Mass in Adults with Neurofibromatosis 1 (NF1)

DTIC Science & Technology

2013-10-01

MD, PhD CONTRACTING ORGANIZATION: University of Utah REPORT DATE : October 2013 TYPE OF REPORT: Annual PREPARED FOR: U.S...of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE ...October 2013 2. REPORT TYPE Annual 3. DATES COVERED 15 September 2012-14 September 2013 4. TITLE AND SUBTITLE A Phase II Trial on the Effect of

Molecular dynamics simulations and novel drug discovery.

PubMed

Liu, Xuewei; Shi, Danfeng; Zhou, Shuangyan; Liu, Hongli; Liu, Huanxiang; Yao, Xiaojun

2018-01-01

Molecular dynamics (MD) simulations can provide not only plentiful dynamical structural information on biomacromolecules but also a wealth of energetic information about protein and ligand interactions. Such information is very important to understanding the structure-function relationship of the target and the essence of protein-ligand interactions and to guiding the drug discovery and design process. Thus, MD simulations have been applied widely and successfully in each step of modern drug discovery. Areas covered: In this review, the authors review the applications of MD simulations in novel drug discovery, including the pathogenic mechanisms of amyloidosis diseases, virtual screening and the interaction mechanisms between drugs and targets. Expert opinion: MD simulations have been used widely in investigating the pathogenic mechanisms of diseases caused by protein misfolding, in virtual screening, and in investigating drug resistance mechanisms caused by mutations of the target. These issues are very difficult to solve by experimental methods alone. Thus, in the future, MD simulations will have wider application with the further improvement of computational capacity and the development of better sampling methods and more accurate force fields together with more efficient analysis methods.

MD Simulations of tRNA and Aminoacyl-tRNA Synthetases: Dynamics, Folding, Binding, and Allostery

PubMed Central

Li, Rongzhong; Macnamara, Lindsay M.; Leuchter, Jessica D.; Alexander, Rebecca W.; Cho, Samuel S.

2015-01-01

While tRNA and aminoacyl-tRNA synthetases are classes of biomolecules that have been extensively studied for decades, the finer details of how they carry out their fundamental biological functions in protein synthesis remain a challenge. Recent molecular dynamics (MD) simulations are verifying experimental observations and providing new insight that cannot be addressed from experiments alone. Throughout the review, we briefly discuss important historical events to provide a context for how far the field has progressed over the past few decades. We then review the background of tRNA molecules, aminoacyl-tRNA synthetases, and current state of the art MD simulation techniques for those who may be unfamiliar with any of those fields. Recent MD simulations of tRNA dynamics and folding and of aminoacyl-tRNA synthetase dynamics and mechanistic characterizations are discussed. We highlight the recent successes and discuss how important questions can be addressed using current MD simulations techniques. We also outline several natural next steps for computational studies of AARS:tRNA complexes. PMID:26184179

75 FR 65021 - National Institute of Allergy and Infectious Diseases; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-21

... Infectious Diseases Special Emphasis Panel; Mechanisms and Prevention of Sexual Transmission of HIV/SIV. Date..., National Institutes of Health/NIAID, 6700B Rockledge Drive, MSC 7616, Bethesda, MD 20892-7616, 301-451-3679...

William Bradley Coley, MD, and the phenomenon of spontaneous regression.

PubMed

Vernon, Leonard F

2018-01-01

The standard definition of spontaneous regression (SR) of cancer is as follows, "…when a malignant tumor partially or completely disappears without treatment or in the presence of therapy which is considered inadequate to exert a significant influence on neoplastic disease." SR is also known as Saint Peregrine tumor, the name taken from a young priest, Peregrine Laziosi (1260 [5]-1345, exact date is unknown), who had been diagnosed with a tumor of the tibia. The mass eventually grew so large that it broke through the skin and became severely infected. The available treatment for this condition was limited to amputation. Historical records report that on the day of surgery, physicians found that the tumor had disappeared and reportedly never returned. To date, the medical literature consists only of individual case studies and overviews of this phenomenon. The most cited work on the subject was done by surgeons Tilden Everson and Warren Cole who reviewed 176 published cases of SR from 1900 to 1960. While a percentage of these were found not to be cases of SR, there remained a number of unexplained cases. A frequent theme in many cases of SR is the co-occurrence of infection. Given the current interest in immunotherapy in the treatment of cancer, this article discusses one of the very early pioneers of this theory, William Bradley Coley, MD, a surgeon who was clearly ahead of his time. Ostracized by colleagues for his belief that stimulation of the immune system could in fact produce a regression of cancer, Coley remained convinced that his theory was right and, while he was not familiar with cytokines such as tumor necrosis factor (TNF), interferons, and streptokinase, he knew instinctively that an innate immune response was taking place.

Tutorial: Determination of thermal boundary resistance by molecular dynamics simulations

NASA Astrophysics Data System (ADS)

Liang, Zhi; Hu, Ming

2018-05-01

Due to the high surface-to-volume ratio of nanostructured components in microelectronics and other advanced devices, the thermal resistance at material interfaces can strongly affect the overall thermal behavior in these devices. Therefore, the thermal boundary resistance, R, must be taken into account in the thermal analysis of nanoscale structures and devices. This article is a tutorial on the determination of R and the analysis of interfacial thermal transport via molecular dynamics (MD) simulations. In addition to reviewing the commonly used equilibrium and non-equilibrium MD models for the determination of R, we also discuss several MD simulation methods which can be used to understand interfacial thermal transport behavior. To illustrate how these MD models work for various interfaces, we will show several examples of MD simulation results on thermal transport across solid-solid, solid-liquid, and solid-gas interfaces. The advantages and drawbacks of a few other MD models such as approach-to-equilibrium MD and first-principles MD are also discussed.

75 FR 43993 - National Institute of Biomedical Imaging and Bioengineering; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-27

... Level), Bethesda, MD 20817. Contact Person: Anthony Demsey, PhD, Director, National Institute of... Level), Bethesda, MD 20817. Closed: 1 p.m. to 3 p.m. Agenda: To review and evaluate grant applications...

75 FR 18216 - National Institute of Biomedical Imaging and Bioengineering; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-09

..., Democracy II, 6707 Democracy Blvd, Suite 900, Bethesda, MD 20892. Contact Person: John K. Hayes, PhD, Scientific Review Officer, 6707 Democracy Boulevard, Suite 959, Democracy Two, Bethesda, MD 20892, 301-451...

75 FR 994 - National Institute of Allergy and Infectious Diseases; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-07

..., 8777 Georgia Avenue, Silver Spring, MD 20910. Contact Person: Lynn Rust, PhD, Scientific Review Officer... of Health, Rockledge 6700, 6700B Rockledge Drive, Bethesda, MD 20817. Contact Person: Lynn Rust, PhD...

Wheelchair securement and occupant restraint system (WTORS) practices in public transit buses.

PubMed

Frost, Karen L; Bertocci, Gina; Salipur, Zdravko

2013-01-01

The purpose of this study was to characterize wheelchair tiedown and occupant restraint system (WTORS) usage in public transit buses based on observations of wheelchair and scooter (wheeled mobility device: WhMD) passenger trips. A retrospective review of on-board video surveillance recordings of WhMD trips on fixed-route, large accessible transit vehicles (LATVs) was performed. Two hundred ninety-five video recordings were collected for review and analysis during the period June 2007-February 2009. Results showed that 73.6% of WhMDs were unsecured during transit. Complete use of all four tiedowns was observed more frequently for manual wheelchairs (14.9%) and power wheelchairs (5.5%), compared to scooters (0.0%), and this difference was significant (p=0.013). Nonuse or misuse (lap belt use only) of the occupant restraint system occurred during 47.5% of WhMD trips. The most frequently observed (52.5%) use of the lap belt consisted of bus operators routing the lap belt around the WhMD seatback in an attempt to secure the WhMD. These findings support the need for development and implementation of WTORS with improved usability and/or WTORS that can be operated independently by WhMD passengers and improved WTORS training for bus operators.

Probiotic (VSL# 3) for Gulf War Illness

DTIC Science & Technology

2017-10-01

Award Number: W81XWH-10-1-0593 TITLE: Probiotic (VSL#3) for Gulf War Illness PRINCIPAL INVESTIGATOR: Ashok Tuteja, M.D. M.P.H. CONTRACTING...THE ABOVE ADDRESS. 1 . REPORT DATE 2. REPORT TYPE 3. DATES COVERED October 2017 Annual 4 . TITLE AND SUBTITLE 5a. CONTRACT NUMBER Probiotic (VSL#3) for...determine whether probiotic VisbiomeTMwill improve 1) Intestinal symptoms of Irritable Bowel Syndrome and 2) Non-intestinal symptoms (fatigue, joint

Effect of Probiotics on Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

PubMed

Huang, Ruixue; Wang, Ke; Hu, Jianan

2016-08-06

It has been reported that gut probiotics play a major role in the bidirectional communication between the gut and the brain. Probiotics may be essential to people with depression, which remains a global health challenge, as depression is a metabolic brain disorder. However, the efficacy of probiotics for depression is controversial. This study aimed to systematically review the existing evidence on the effect of probiotics-based interventions on depression. Randomized, controlled trials, identified through screening multiple databases and grey literature, were included in the meta-analysis. The meta-analysis was performed using Review Manager 5.3 software using a fixed-effects model. The meta-analysis showed that probiotics significantly decreased the depression scale score (MD (depressive disorder) = -0.30, 95% CI (-0.51--0.09), p = 0.005) in the subjects. Probiotics had an effect on both the healthy population (MD = -0.25, 95% CI (-0.47--0.03), p = 0.03) and patients with major depressive disorder (MDD) (MD = -0.73, 95% CI (-1.37--0.09), p = 0.03). Probiotics had an effect on the population aged under 60 (MD = -0.43, 95% CI (-0.72--0.13), p = 0.005), while it had no effect on people aged over 65 (MD = -0.18, 95% CI (-0.47-0.11), p = 0.22). This is the first systematic review and meta-analysis with the goal of determining the effect of probiotics on depression. We found that probiotics were associated with a significant reduction in depression, underscoring the need for additional research on this potential preventive strategy for depression.

77 FR 45644 - National Institute of Biomedical Imaging and Bioengineering; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-01

... Drive, Conference Room 1, Potomac, MD 20854. Closed: 1:00 p.m. to 3:00 p.m. Agenda: To review and... Newbridge Drive, Conference Room 1, Potomac, MD 20854. Contact Person: Anthony Demsey, Ph.D., Director...

Trigger finger

MedlinePlus

... by: C. Benjamin Ma, MD, Assistant Professor, Chief, Sports Medicine and Shoulder Service, UCSF Department of Orthopaedic Surgery. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team. Related MedlinePlus Health Topics Finger Injuries and Disorders ...

78 FR 10186 - Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-13

..., MD 20814. Contact Person: Peter Zelazowski, Ph.D., Scientific Review Officer, Division of Scientific... Executive Blvd., Room 5B01, Bethesda, MD 20892, 301-435-6902, peter[email protected] . (Catalogue of...

76 FR 61720 - Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-05

..., MD 20814. Contact Person: Peter Zelazowski, PhD, Scientific Review Officer, Division of Scientific... Executive Blvd., Room 5B01, Bethesda, MD 20892, 301-435-6902, peter[email protected] . (Catalogue of...

77 FR 6570 - Eunice Kennedy Shriver National Institute of Child Health and Human Development; Notice of Closed...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-08

..., MD 20852. Contact Person: Peter Zelazowski, Ph.D., Scientific Review Officer, Division of Scientific... Executive Blvd., Room 5B01, Bethesda, MD 20892, (301) 435-6902, peter[email protected] . (Catalogue of...

Concurrent aerobic plus resistance exercise versus aerobic exercise alone to improve health outcomes in paediatric obesity: a systematic review and meta-analysis.

PubMed

García-Hermoso, Antonio; Ramírez-Vélez, Robinson; Ramírez-Campillo, Rodrigo; Peterson, Mark D; Martínez-Vizcaíno, Vicente

2018-02-01

To determine if the combination of aerobic and resistance exercise is superior to aerobic exercise alone for the health of obese children and adolescents. Systematic review with meta-analysis. Computerised search of 3 databases (MEDLINE, EMBASE, and Cochrane Controlled Trials Registry). Studies that compared the effect of supervised concurrent exercise versus aerobic exercise interventions, with anthropometric and metabolic outcomes in paediatric obesity (6-18 years old). The mean differences (MD) of the parameters from preintervention to postintervention between groups were pooled using a random-effects model. 12 trials with 555 youths were included in the meta-analysis. Compared with aerobic exercise alone, concurrent exercise resulted in greater reductions in body mass (MD=-2.28 kg), fat mass (MD=-3.49%; and MD=-4.34 kg) and low-density lipoprotein cholesterol (MD=-10.20 mg/dL); as well as greater increases in lean body mass (MD=2.20 kg) and adiponectin level (MD=2.59 μg/mL). Differences were larger for longer term programmes (>24 weeks). Concurrent aerobic plus resistance exercise improves body composition, metabolic profiles, and inflammatory state in the obese paediatric population. CRD42016039807. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Oropharyngeal dysphagia in myotonic dystrophy type 1: a systematic review.

PubMed

Pilz, Walmari; Baijens, Laura W J; Kremer, Bernd

2014-06-01

A systematic review was conducted to investigate the pathophysiology of and diagnostic procedures for oropharyngeal dysphagia in myotonic dystrophy (MD). The electronic databases Embase, PubMed, and The Cochrane Library were used. The search was limited to English, Dutch, French, German, Spanish, and Portuguese publications. Sixteen studies met the inclusion criteria. Two independent reviewers assessed the methodological quality of the included articles. Swallowing assessment tools, the corresponding protocols, the studies' outcome measurements, and main findings are summarized and presented. The body of literature on pathophysiology of swallowing in dysphagic patients with MD type 1 remains scant. The included studies are heterogeneous with respect to design and outcome measures and hence are not directly comparable. More importantly, most studies had methodological problems. These are discussed in detail and recommendations for further research on diagnostic examinations for swallowing disorders in patients with MD type 1 are provided.

76 FR 16798 - National Institutes of Health

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-25

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review.... Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892 (Telephone Conference..., National Institutes of Health, 6701 Rockledge Drive, Room 4136, MSC 7850, Bethesda, MD 20892, (301) 435...

76 FR 42718 - National Cancer Institute; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-19

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Cancer Institute... personal privacy. Name of Committee: National Cancer Institute Special Emphasis Panel, Cancer Therapies..., Rockville, MD 20582. Contact Person: Delia Tang, MD, Scientific Review Officer, National Cancer Institute...

Synovial biopsy

MedlinePlus

... Updated by: C. Benjamin Ma, MD, Professor, Chief, Sports Medicine and Shoulder Service, UCSF Department of Orthopaedic Surgery, San Francisco, CA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team. Autoimmune Diseases Read more Biopsy Read more Fungal ...

Carpal tunnel biopsy

MedlinePlus

... Updated by: C. Benjamin Ma, MD, Professor, Chief, Sports Medicine and Shoulder Service, UCSF Department of Orthopaedic Surgery, San Francisco, CA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team. Amyloidosis Read more Biopsy Read more Carpal Tunnel ...

Metatarsus adductus

MedlinePlus

... 2016 Updated by: C. Benjamin Ma, MD, Chief, Sports Medicine and Shoulder Service, UCSF Department of Orthopaedic Surgery, San Francisco, CA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team. Foot Injuries and Disorders Read more NIH MedlinePlus ...

Tendon repair

MedlinePlus

... Updated by: C. Benjamin Ma, MD, Professor, Chief, Sports Medicine and Shoulder Service, UCSF Department of Orthopaedic Surgery, San Francisco, CA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team. Sprains and Strains Read more NIH MedlinePlus Magazine ...

Compartment syndrome

MedlinePlus

... Updated by: C. Benjamin Ma, MD, Professor, Chief, Sports Medicine and Shoulder Service, UCSF Department of Orthopaedic Surgery, San Francisco, CA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team. Muscle Disorders Read more NIH MedlinePlus Magazine Read ...

Kyphosis

MedlinePlus

... Updated by: C. Benjamin Ma, MD, Professor, Chief, Sports Medicine and Shoulder Service, UCSF Department of Orthopaedic Surgery, San Francisco, CA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team. Spine Injuries and Disorders Read more NIH MedlinePlus ...

Tenosynovitis

MedlinePlus

... Updated by: C. Benjamin Ma, MD, Professor, Chief, Sports Medicine and Shoulder Service, UCSF Department of Orthopaedic Surgery, San Francisco, CA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team. Tendinitis Read more NIH MedlinePlus Magazine Read more ...

Bunion removal

MedlinePlus

... Updated by: C. Benjamin Ma, MD, Professor, Chief, Sports Medicine and Shoulder Service, UCSF Department of Orthopaedic Surgery, San Francisco, CA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team. Toe Injuries and Disorders Read more NIH MedlinePlus ...

Hammer toe

MedlinePlus

... by: C. Benjamin Ma, MD, Assistant Professor, Chief, Sports Medicine and Shoulder Service, UCSF Department of Orthopaedic Surgery, San Francisco, CA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team. Toe Injuries and Disorders Read more NIH MedlinePlus ...

Replantation of digits

MedlinePlus

... Updated by: C. Benjamin Ma, MD, Professor, Chief, Sports Medicine and Shoulder Service, UCSF Department of Orthopaedic Surgery, San Francisco, CA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team. Finger Injuries and Disorders Read more Toe Injuries ...

76 FR 62081 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-06

... Rockledge Drive, Bethesda, MD 20892 (Virtual Meeting). Contact Person: Ai-Ping Zou, M.D., PhD, Scientific..., Comparative Medicine; 93.333, Clinical Research, 93.306, 93.333, 93.337, 93.393-93.396, 93.837-93.844, 93.846...

ALTERNATIVE ASBESTOS CONTROL METHOD (AACM) RESEARCH - BALTIMORE, MD

EPA Science Inventory

This presentation describes the status to date of the Alternative Asbestos Control Method research, which is intended as a possible alternative technology for use in the demolition of buildings that contain asbestos and are covered under the regulatory requirements of the Asbesto...

78 FR 6124 - National Institute of Mental Health; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-29

... Institutes of Health, Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852, (Telephone... Activities, National Institute of Mental Health, NIH, Neuroscience Center, 6001 Executive Blvd., Room 6153... Institute of Mental Health Special Emphasis Panel, Cognitive Neuroscience and Schizophrenia Panel. Date...

Empathic and Self-Regulatory Processes Governing Doping Behavior

PubMed Central

Boardley, Ian D.; Smith, Alan L.; Mills, John P.; Grix, Jonathan; Wynne, Ceri

2017-01-01

Evidence associating doping behavior with moral disengagement (MD) has accumulated over recent years. However, to date, research examining links between MD and doping has not considered key theoretically grounded influences and outcomes of MD. As such, there is a need for quantitative research in relevant populations that purposefully examines the explanatory pathways through which MD is thought to operate. Toward this end, the current study examined a conceptually grounded model of doping behavior that incorporated empathy, doping self-regulatory efficacy (SRE), doping MD, anticipated guilt and self-reported doping/doping susceptibility. Participants were specifically recruited to represent four key physical-activity contexts and consisted of team- (n = 195) and individual- (n = 169) sport athletes and hardcore- (n = 125) and corporate- (n = 121) gym exercisers representing both genders (nmale = 371; nfemale = 239); self-reported lifetime prevalence of doping across the sample was 13.6%. Each participant completed questionnaires assessing the aforementioned variables. Structural equation modeling indicated strong support for all study hypotheses. Specifically, we established: (a) empathy and doping SRE negatively predicted reported doping; (b) the predictive effects of empathy and doping SRE on reported doping were mediated by doping MD and anticipated guilt; (c) doping MD positively predicted reported doping; (d) the predictive effects of doping MD on reported doping were partially mediated by anticipated guilt. Substituting self-reported doping for doping susceptibility, multisample analyses then demonstrated these predictive effects were largely invariant between males and females and across the four physical-activity contexts represented. These findings extend current knowledge on a number of levels, and in doing so aid our understanding of key psychosocial processes that may govern doping behavior across key physical-activity contexts. PMID:29018370

Empathic and Self-Regulatory Processes Governing Doping Behavior.

PubMed

Boardley, Ian D; Smith, Alan L; Mills, John P; Grix, Jonathan; Wynne, Ceri

2017-01-01

Evidence associating doping behavior with moral disengagement (MD) has accumulated over recent years. However, to date, research examining links between MD and doping has not considered key theoretically grounded influences and outcomes of MD. As such, there is a need for quantitative research in relevant populations that purposefully examines the explanatory pathways through which MD is thought to operate. Toward this end, the current study examined a conceptually grounded model of doping behavior that incorporated empathy, doping self-regulatory efficacy (SRE), doping MD, anticipated guilt and self-reported doping/doping susceptibility. Participants were specifically recruited to represent four key physical-activity contexts and consisted of team- ( n = 195) and individual- ( n = 169) sport athletes and hardcore- ( n = 125) and corporate- ( n = 121) gym exercisers representing both genders ( n male = 371; n female = 239); self-reported lifetime prevalence of doping across the sample was 13.6%. Each participant completed questionnaires assessing the aforementioned variables. Structural equation modeling indicated strong support for all study hypotheses. Specifically, we established: (a) empathy and doping SRE negatively predicted reported doping; (b) the predictive effects of empathy and doping SRE on reported doping were mediated by doping MD and anticipated guilt; (c) doping MD positively predicted reported doping; (d) the predictive effects of doping MD on reported doping were partially mediated by anticipated guilt. Substituting self-reported doping for doping susceptibility, multisample analyses then demonstrated these predictive effects were largely invariant between males and females and across the four physical-activity contexts represented. These findings extend current knowledge on a number of levels, and in doing so aid our understanding of key psychosocial processes that may govern doping behavior across key physical-activity contexts.

Genetic evidence for an ethnic diversity in the susceptibility to Ménière's disease.

PubMed

Ohmen, Jeffrey Douglass; White, Cory H; Li, Xin; Wang, Juemei; Fisher, Laurel M; Zhang, Huan; Derebery, Mary Jennifer; Friedman, Rick A

2013-09-01

Ménière's disease (MD) is a debilitating disorder of the inner ear characterized by cochlear and vestibular dysfunction. The cause of this disease is still unknown, and epidemiological data for MD are sparse. From the existing literature, women seem to be more susceptible than men, and Caucasians seem to be more susceptible than Asians. In this article, we characterize a large definite MD cohort for sex and age of onset of disease and use molecular genetic methodologies to characterize ethnicity. Medical record review for sex and age of onset. Ancestry analysis compared results from the principal component analysis of whole-genome genotype data from MD patients to self-identified ancestry in control samples. House Clinic in Los Angeles. Definitive MD patients. Our review of medical records for definitive MD patients reveals that women are more susceptible than men. We also find that men and women have nearly identical age of onset for disease. Lastly, interrogation of molecular genetic data with principal component analysis allowed detailed observations about the ethnic ancestry of our patients. Comparison of the ethnicity of MD patients presenting to our tertiary care clinic with the self-recollected ethnicity of all patients visiting the clinic revealed an ethnic bias, with Caucasians presenting at a higher frequency than expected and the remaining major ethnicities populating Los Angeles (Hispanics, Blacks, and Asians) presenting at a lower frequency than expected. To the best of our knowledge, this report is the first ethnic characterization of a large MD cohort from a large metropolitan region using molecular genetic data. Our data suggest that there is a bias in sex and ethnic susceptibility to this disease.

Wheelchair tiedown and occupant restraint practices in paratransit vehicles.

PubMed

Frost, Karen; Bertocci, Gina; Smalley, Craig

2018-01-01

The purpose of this study was to characterize wheelchair tiedown and occupant restraint system (WTORS) usage in paratransit vehicles based on observations of wheelchair and scooter (wheeled mobility devices, collectively, "WhMD") passenger trips. A retrospective review of on-board video monitoring recordings of WhMD trips was conducted. Four hundred seventy-five video recordings were collected for review and analysis. The use of all four tiedowns to secure the WhMD was observed more frequently for power WhMDs (82%) and manual WhMDs (80%) compared to scooters (39%), and this difference was significant (p< 0.01). Nonuse or misuse of the occupant restraint system occurred during 88% of WhMD trips, and was most frequently due to vehicle operator neglect in applying the shoulder belt. Despite the absence of incidents or injuries in this study, misuse and nonuse of WTORS potentially place WhMD seated passengers at higher risk of injury during transit. These findings support the need for improved vehicle operator training and passenger education on the proper use of WTORS and development of WTORS with improved usability and/or alternative technologies that can be automated or used independently.

Multiscale molecular dynamics simulations of rotary motor proteins.

PubMed

Ekimoto, Toru; Ikeguchi, Mitsunori

2018-04-01

Protein functions require specific structures frequently coupled with conformational changes. The scale of the structural dynamics of proteins spans from the atomic to the molecular level. Theoretically, all-atom molecular dynamics (MD) simulation is a powerful tool to investigate protein dynamics because the MD simulation is capable of capturing conformational changes obeying the intrinsically structural features. However, to study long-timescale dynamics, efficient sampling techniques and coarse-grained (CG) approaches coupled with all-atom MD simulations, termed multiscale MD simulations, are required to overcome the timescale limitation in all-atom MD simulations. Here, we review two examples of rotary motor proteins examined using free energy landscape (FEL) analysis and CG-MD simulations. In the FEL analysis, FEL is calculated as a function of reaction coordinates, and the long-timescale dynamics corresponding to conformational changes is described as transitions on the FEL surface. Another approach is the utilization of the CG model, in which the CG parameters are tuned using the fluctuation matching methodology with all-atom MD simulations. The long-timespan dynamics is then elucidated straightforwardly by using CG-MD simulations.

76 FR 55930 - National Institutes of Health

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-09

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center For Scientific Review..., National Institutes of Health, 6701 Rockledge Drive, Room 6194, MSC 7804, Bethesda, MD 20892, 301-996-6208... of Health, 6701 Rockledge Drive, Bethesda, MD 20892, (Virtual Meeting). Contact Person: Joseph Thomas...

Bursitis of the heel

MedlinePlus

... by: C. Benjamin Ma, MD, Assistant Professor, Chief, Sports Medicine and Shoulder Service, UCSF Department of Orthopaedic Surgery, San Francisco, CA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team. Bursitis Read more Heel Injuries and Disorders Read ...

Limited range of motion

MedlinePlus

... Updated by: C. Benjamin Ma, MD, Professor, Chief, Sports Medicine and Shoulder Service, UCSF Department of Orthopaedic Surgery, San Francisco, CA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team. Joint Disorders Read more NIH MedlinePlus Magazine Read ...

76 FR 10380 - National Institute of Mental Health; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-24

..., Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852, (Telephone Conference Call). Contact Person... Mental Health, NIH, Neuroscience Center, 6001 Executive Blvd., Room 6151, MSC 9606, Bethesda, MD 20892.... Agenda: To review and evaluate grant applications. Place: National Institutes of Health, Neuroscience...

77 FR 38847 - National Institute of Mental Health; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-29

.... Agenda: To review and evaluate grant applications. Place: National Institutes of Health, Neuroscience... of Mental Health, NIH, Neuroscience Center, 6001 Executive Blvd., Room 6140, MSC 9608, Bethesda, MD... Health,Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852, (Telephone Conference Call...

76 FR 34717 - National Institute of Mental Health; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-14

..., Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852, (Telephone Conference Call) Contact Person... Mental Health, NIH, Neuroscience Center, 6001 Executive Blvd., Room 6151, MSC 9606, Bethesda, MD 20892.... Agenda: To review and evaluate grant applications. Place: National Institutes of Health, Neuroscience...

76 FR 60508 - National Institute of Mental Health Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-29

.... Agenda: To review and evaluate grant applications. Place: National Institutes of Health, Neuroscience... of Mental Health, NIH, Neuroscience Center/Room 6138/MSC 9608, 6001 Executive Boulevard, Bethesda, MD..., Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852 (Telephone Conference Call). Contact Person...

IN-VITRO evidence for the protective properties of the main components of the Mediterranean diet against colorectal cancer: A systematic review.

PubMed

Rotelli, M T; Bocale, D; De Fazio, M; Ancona, P; Scalera, I; Memeo, R; Travaglio, E; Zbar, A P; Altomare, D F

2015-09-01

Epidemiological studies have shown that the incidence and mortality rates of colorectal cancer (CRC) vary over 10-fold worldwide where within Westernized societies lower rates are observed amongst populations living within the Mediterranean basin, suggesting a significant influence of environment and dietary style in CRC carcinogenesis. Interpretation of the data concerning the benefits of mediterranean (MD) diet is difficult in vivo because of the variability of alimentary regimens used, the differing compliance with dietary supplementation and because of the non-uniform duration of patient cohort observation. Therefore, the aim of this review is to evaluate the in-vitro effects on colorectal cancer cell lines. the literature concerning the in-vitro effects of 4 of the principal components symbolizing the MD such as olive oil (polyphenol), red chili (capsaicin), tomato (lycopene) and red grapes (resveratrol) have been systematically reviewed. Several studies have demonstrated that polyphenols form olive oil, lycopene, resveratrol and capsaicin have multiple anticancer properties affecting several metabolic pathways involved in cancerogenesis, apoptosis, and metastasis in CRC cell lines. This review summarizes some of the most recent data potentially supportive of the use of MD in CRC chemoprevention, analyzing the in vitro effects of individual components of the MD on CRC cell development, progression, metastasis and apoptosis. Copyright © 2015 Elsevier Ltd. All rights reserved.

The effectiveness of physical therapies for patients with base of thumb osteoarthritis: Systematic review and meta-analysis.

PubMed

Ahern, Malene; Skyllas, Jason; Wajon, Anne; Hush, Julia

2018-06-01

Trapeziometacarpal osteoarthritis (known as base of thumb OA) is a common condition causing pain and disability worldwide. The purpose of this review was to evaluate the effectiveness of multimodal and unimodal physical therapies for base of thumb osteoarthritis (OA) compared with usual care, placebo or sham interventions. Systematic review and meta-analysis. We searched MEDLINE (PubMed), CINAHL, Embase, AMED, PEDro, Cochrane Database of Systematic Review, Cochrane Register of Controlled Trials (CENTRAL) from inception to May 2017. Randomized controlled trials involving adults comparing physical therapy treatment for base of thumb OA with an inactive control (placebo or sham treatment) and reported pain, strength or functional outcomes were included. Meta-analyses were performed where possible. Methodological risk of bias was assessed with the Cochrane Risk of Bias tool. Five papers with low risk of bias were included. Meta-analyses of mean differences (MD) with 95% confidence intervals (95% CI), were calculated for between-group differences in point estimates at 4 weeks post-intervention. Multimodal and unimodal physical therapies resulted in clinically worthwhile improvements in pain intensity (MD 2.9 [95% CI 2.8 to 3.0]; MD 3.1 [95% CI 2.5 to 3.8] on a 0-10 scale, respectively). Hand function improved following unimodal treatments (MD 6.8 points [95% CI 1.7 to 11.9)] on a 0-100 scale) and after a multimodal treatment (MD 20.5 (95%CI -0.7 to 41.7). High quality evidence shows unimodal and multimodal physical therapy treatments can result in clinically worthwhile improvements in pain and function for patients with base of thumb OA. Copyright © 2018 Elsevier Ltd. All rights reserved.

Effect of Probiotics on Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

PubMed Central

Huang, Ruixue; Wang, Ke; Hu, Jianan

2016-01-01

It has been reported that gut probiotics play a major role in the bidirectional communication between the gut and the brain. Probiotics may be essential to people with depression, which remains a global health challenge, as depression is a metabolic brain disorder. However, the efficacy of probiotics for depression is controversial. This study aimed to systematically review the existing evidence on the effect of probiotics-based interventions on depression. Randomized, controlled trials, identified through screening multiple databases and grey literature, were included in the meta-analysis. The meta-analysis was performed using Review Manager 5.3 software using a fixed-effects model. The meta-analysis showed that probiotics significantly decreased the depression scale score (MD (depressive disorder) = −0.30, 95% CI (−0.51–−0.09), p = 0.005) in the subjects. Probiotics had an effect on both the healthy population (MD = −0.25, 95% CI (−0.47–−0.03), p = 0.03) and patients with major depressive disorder (MDD) (MD = −0.73, 95% CI (−1.37–−0.09), p = 0.03). Probiotics had an effect on the population aged under 60 (MD = −0.43, 95% CI (−0.72–−0.13), p = 0.005), while it had no effect on people aged over 65 (MD = −0.18, 95% CI (−0.47–0.11), p = 0.22). This is the first systematic review and meta-analysis with the goal of determining the effect of probiotics on depression. We found that probiotics were associated with a significant reduction in depression, underscoring the need for additional research on this potential preventive strategy for depression. PMID:27509521

Using molecular simulation to explore the nanoscale dynamics of the plant kinome.

PubMed

Moffett, Alexander S; Shukla, Diwakar

2018-03-09

Eukaryotic protein kinases (PKs) are a large family of proteins critical for cellular response to external signals, acting as molecular switches. PKs propagate biochemical signals by catalyzing phosphorylation of other proteins, including other PKs, which can undergo conformational changes upon phosphorylation and catalyze further phosphorylations. Although PKs have been studied thoroughly across the domains of life, the structures of these proteins are sparsely understood in numerous groups of organisms, including plants. In addition to efforts towards determining crystal structures of PKs, research on human PKs has incorporated molecular dynamics (MD) simulations to study the conformational dynamics underlying the switching of PK function. This approach of experimental structural biology coupled with computational biophysics has led to improved understanding of how PKs become catalytically active and why mutations cause pathological PK behavior, at spatial and temporal resolutions inaccessible to current experimental methods alone. In this review, we argue for the value of applying MD simulation to plant PKs. We review the basics of MD simulation methodology, the successes achieved through MD simulation in animal PKs, and current work on plant PKs using MD simulation. We conclude with a discussion of the future of MD simulations and plant PKs, arguing for the importance of molecular simulation in the future of plant PK research. © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.

[Autism, genetics and synaptic function alterations].

PubMed

Perche, O; Laumonnier, F; Baala, L; Ardourel, M-Y; Menuet, A; Robin, V; Mortaud, S; Montécot-Dubourg, C; Richard, O; Pichon, J; Briault, S

2010-10-01

Autism is a neurodevelopmental disorder characterized by a deficit of language and communication both associated with a restricted repertoire of activities and interests. The current prevalence of autistic disorder stricto sensu is estimated at 1/500 whereas autism spectrum disorders (ASD) increases up to 1/150 to 1/200. Mental deficiency (MD) and epilepsy are present in numerous autistic individuals. Consequently, autism is as a major public health issue. Autism was first considered as a non biological disease; however various rational approaches for analysing epidemiological data suggested the possibility of the influence of genetic factors. In 2003, this hypothesis was clearly illustrated by the characterization of genetic mutations transmitted through a mendelian manner. Subsequently, the glutamate synapse appeared as a preferential causal target in autism because the identified genes encoded proteins present in this structure. Strikingly, the findings that an identical genetic dysfunction of the synapse might also explain some MD suggested the possibility of a genetic comorbidity between these neurodevelopmental conditions. To date, various identified genes are considered indifferently as "autism" or "MD" genes. The characterization of mutations in the NLGN4X gene in patients with Asperger syndrome, autism without MD, or MD without autism, was the first example. It appears that a genetic continuum between ASD on one hand, and between autism and MD on the other hand, is present. Consequently, it is likely that genes already involved in MD will be found mutated in autistic patients and will represent future target for finding new factors in autism. Copyright © 2010 Elsevier Masson SAS. All rights reserved.

Growth hormone for intestinal adaptation in patients with short bowel syndrome: systematic review and meta-analysis of randomized controlled trials.

PubMed

Guo, Ming-Xiao; Li, You-Sheng; Fan, Lei; Li, Jie-Shou

2011-06-01

The purpose of this systematic review was to assess the efficacy of growth hormone (GH) treatment in patients with short bowel syndrome (SBS). Electronic searches were performed to identify all publications describing randomized controlled trials (RCTs) on the use of GH with or without glutamine for the treatment of patients with SBS. The outcomes of interest were body weight, lean body mass, and intestinal absorption function. Four trials involving 70 patients were included in the review. A meta-analysis of these trials suggested that GH had a positive effect in terms of increased weight (mean difference [MD] = 1.66; 95% CI, 0.69-2.63, P < 0.001), lean body mass (MD = 1.93; 95% CI, 0.97-2.90; P < 0.001), energy absorption (MD = 4.42; 95% CI, 0.26-8.58; P = 0.04), nitrogen absorption (MD = 4.85; 95% CI, 0.20-9.49; P = 0.04), and fat absorption (MD = 5.02; 95% CI, 0.21-9.82; P = 0.04) for patients with SBS. Adverse effects occurred during active treatment in all trials. Only 1 trial included a 12-week follow-up study. The results suggest a possible short-term benefit in terms of body weight, lean body mass, and absorptive capacities; however, no conclusion of long-term efficacy of GH could be obtained. Large-scale, long-term follow-up RCTs are needed to confirm the efficacy and tolerability of GH in the future.

76 FR 3917 - National Eye Institute; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-21

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Eye Institute... personal privacy. Name of Committee: National Eye Institute Special Emphasis Panel, Training Grants. Date...: National Eye Institute, 5635 Fishers Lane, Rockville, MD 20852 (Virtual Meeting). Contact Person: Daniel R...

77 FR 35855 - Safety Zone, Temporary Change for Recurring Fifth Coast Guard District Fireworks Displays...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-15

..., approximately 500 yards northwest of the waterfront at Oxford, MD. * * * * * Dated: June 4, 2012. Mark P. O'Malley, Captain, U.S. Coast Guard, Captain of the Port Baltimore. [FR Doc. 2012-14647 Filed 6-14-12; 8:45...

78 FR 24221 - National Library of Medicine; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-24

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Treatment of Sleep Apnea in Patients with Cervical Spinal Cord Injury

DTIC Science & Technology

2017-08-01

Badr, M.D. CONTRACTING ORGANIZATION: Wayne State University Detroit, MI 48201 REPORT DATE: August 2017 TYPE OF REPORT: Annual PREPARED FOR...measurements of air pressure and airflow. Our methods will allow us to quantify ventilation, measure the severity of inspiratory flow limitation

77 FR 64491 - National Climate Assessment and Development Advisory Committee (NCADAC)

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-22

... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration National Climate Assessment... National Climate Assessment and Development Advisory Committee (NCADAC). Time and Date: The meeting will be... One Veterans Place Silver Spring, MD 20910. Please check the National Climate Assessment Web site for...

Repetitive peripheral magnetic stimulation for activities of daily living and functional ability in people after stroke.

PubMed

Momosaki, Ryo; Yamada, Naoki; Ota, Erika; Abo, Masahiro

2017-06-23

Repetitive peripheral magnetic stimulation (rPMS) is a form of therapy that creates painless stimulation of deep muscle structures to improve motor function in people with physical impairment from brain or nerve disorders. Use of rPMS for people after stroke has been identified as a feasible approach to improve activities of daily living and functional ability. However, no systematic reviews have assessed the findings of available trials. The effect and safety of this intervention for people after stroke currently remain uncertain. To assess the effect of rPMS for improving activities of daily living and functional ability in people after stroke. We searched the Cochrane Stroke Group Trials Register (August 2016), the Cochrane Central Register of Controlled Trials (CENTRAL; 2016, Issue 8) in the Cochrane Library (August 2016), MEDLINE Ovid (November 2016), Embase Ovid (August 2016), the Cumulative Index to Nursing and Allied Health Literature (CINAHL) in Ebsco (August 2016), PsycINFO Ovid (August 2016), the Allied and Complementary Medicine Database (AMED) Ovid (August 2016), Occupational Therapy Systematic Evaluation of Evidence (OTseeker) (August 2016), the Physiotherapy Evidence Database (PEDro) (October 2016), and ICHUSHI Web (October 2016). We also searched five ongoing trial registries, screened reference lists, and contacted experts in the field. We placed no restrictions on the language or date of publication when searching the electronic databases. We included randomised controlled trials (RCTs) conducted to assess the therapeutic effect of rPMS for people after stroke. Comparisons eligible for inclusion were (1) active rPMS only compared with 'sham' rPMS (a very weak form of stimulation or a sound only); (2) active rPMS only compared with no intervention; (3) active rPMS plus rehabilitation compared with sham rPMS plus rehabilitation; and (4) active rPMS plus rehabilitation compared with rehabilitation only. Two review authors independently assessed studies for inclusion. The same review authors assessed methods and risk of bias and extracted data. We contacted trial authors to ask for unpublished information if necessary. We resolved all disagreements through discussion. We included three trials (two RCTs and one cross-over trial) involving 121 participants. Blinding of participants and physicians was well reported in all trials, and overall risk of bias was low. We found no clear effect of rPMS on activities of daily living at the end of treatment (mean difference (MD) -3.00, 95% confidence interval (CI) -16.35 to 10.35; low-quality evidence) and at the end of follow-up (MD -2.00, 95% CI -14.86 to 10.86; low-quality evidence). Investigators in one study with 63 participants observed no statistical difference in improvement of upper limb function at the end of treatment (MD 2.00, 95% CI -4.91 to 8.91) and at the end of follow-up (MD 4.00, 95% CI -2.92 to 10.92). One trial with 18 participants showed that rPMS treatment was not associated with improved muscle strength at the end of treatment (MD 3.00, 95% CI -2.44 to 8.44). Another study reported a significant decrease in spasticity of the elbow at the end of follow-up (MD -0.48, 95% CI -0.93 to -0.03). No studies provided information on lower limb function and death. Based on the GRADE approach, we judged the certainty of evidence related to the primary outcome as low owing to the small sample size of one study. Available trials provided inadequate evidence to permit any conclusions about routine use of rPMS for people after stroke. Additional trials with large sample sizes are needed to determine an appropriate rPMS protocol as well as long-term effects. We identified three ongoing trials and will include these trials in the next review update.

Repair of webbed fingers or toes

MedlinePlus

... Updated by: C. Benjamin Ma, MD, Professor, Chief, Sports Medicine and Shoulder Service, UCSF Department of Orthopaedic Surgery, San Francisco, CA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team. Finger Injuries and Disorders Read more Toe Injuries ...

76 FR 43333 - National Institute of Neurological Disorders and Stroke; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-20

...: To review and evaluate grant applications. Place: National Institutes of Health, Neuroscience Center.../NIH/DHHS/Neuroscience Center, 6001 Executive Blvd., Suite 3208, MSC 9529, Bethesda, MD 20892-9529, 301... Health, Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852, (Telephone Conference Call...

76 FR 69747 - National Institute of Neurological Disorders and Stroke; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-09

..., Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852, (Telephone Conference Call). Contact Person... Research, NINDS/NIH/DHHS/Neuroscience Center, 6001 Executive Blvd., Suite 3208, MSC 9529, Bethesda, MD.... Agenda: To review and evaluate grant applications. Place: National Institutes of Health, Neuroscience...

75 FR 8373 - National Institute of Mental Health; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-24

.... Agenda: To review and evaluate grant applications. Place: National Institutes of Health, Neuroscience... Health, NIH, Neuroscience Center, 6001 Executive Boulevard, Room 6132, MSC 9608, Bethesda, MD 20852-9608... Mental Health, NIH, Neuroscience Center, 6001 Executive Blvd., Room 6148, MSC 9609, Rockville, MD 20852...

Acceleration of Regeneration of Large Gap Peripheral Nerve Injuries Using Acellular Nerve Allografts plus amniotic Fluid Derived Stem Cells (AFS)

DTIC Science & Technology

2016-09-01

AWARD NUMBER: W811XWH-13-1-0310 TITLE: Acceleration of Regeneration of Large-Gap Peripheral Nerve Injuries Using Acellular Nerve Allografts...plus amniotic Fluid Derived Stem Cells (AFS). PRINCIPAL INVESTIGATOR: Zhongyu Li, MD, PhD RECIPIENT: Wake Forest University Health Sciences...REPORT DATE September 2016 2. REPORT TYPE Annual 3. DATES COVERED 1Sep2015 - 31Aug2016 4. TITLE AND SUBTITLE Acceleration of Regeneration of Large

Control of Atherosclerosis Regression by PRMT2 in Diabetes

DTIC Science & Technology

2017-08-01

AWARD NUMBER: W81XWH-16-1-0374 TITLE: Control of Atherosclerosis Regression by PRMT2 in Diabetes PRINCIPAL INVESTIGATOR: Edward Fisher, MD, PhD...for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM...TO THE ABOVE ADDRESS. 1. REPORT DATE August 2017 2. REPORT TYPE Annual 3. DATES COVERED 01 Aug 2016- 31-July 2017 4. TITLE AND SUBTITLE Control of

Environmentally Friendly Cleaners for Removing Tar and Asphalt from Tactical and Transportation Vehicles

DTIC Science & Technology

2011-05-01

Vehicles Veera M. Boddu (Speaker), Joyce C. Baird, Qi Chen, and Chris Myers US Army Engineer Research & Development Center (ERDC-CERL) Champaign, IL...61822 Pam Khabra TACOM/TARDEC, Warren, MI 48397 Wayne Ziegler Army Research Laboratories (ARL/WMRD) Bldg 4600, APG, MD 21005 Malcolm E. McLeod US ...of information if it does not display a currently valid OMB control number. 1. REPORT DATE MAY 2011 2. REPORT TYPE 3. DATES COVERED 00-00-2011

Complications of serogroup B meningococcal disease in survivors: a review.

PubMed

Dastouri, Fereshteh; Hosseini, Ahmad Mirmohammad; Haworth, Elizabeth; Khandaker, Gulam; Rashid, Harunor; Booy, Robert

2014-01-01

This systematic review evaluates the prevalence of long-term complications of serogroup B meningococcal disease (MD) in light of the recent licensure of a vaccine against meningococcal B disease. Twelve appropriate studies were identified by searching available databases from 1946 to July 2014. The average prevalence of hearing impairment was 4.2% among serogroup B MD survivors; 2.3% suffered amputation and 2.3% developed seizures. When compared with complications due to non-meningococcal B bacterial meningitis, physical impairment and seizures were more common in survivors of meningococcal B disease but hearing impairment had similar prevalence. Few studies quantified less frequent complications such as visual impairment and cognitive dysfunction. Better comprehensive reporting of the complications and costs of serogroup B MD in survivors and their families is needed to inform vaccination policy.

75 FR 43491 - Sunshine Act Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-26

....-10:30 a.m., Wednesday July 21, 2010. Changes to Meeting: Meeting postponed. For a recorded message containing the latest agenda information, call (301) 504-7948. FOR FURTHER INFORMATION CONTACT: Contact..., Bethesda, MD 20814 (301) 504-7923. Dated: July 21, 2010. . Todd A. Stevenson, Secretary. [FR Doc. 2010...

77 FR 56624 - Sunshine Act Meeting Notice

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2012-09-13

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75 FR 6042 - National Library of Medicine; Notice of Closed Meeting

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2010-02-05

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76 FR 9031 - National Library of Medicine; Notice of Closed Meeting

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2011-02-16

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75 FR 81631 - National Institute of Allergy and Infectious Diseases; Notice of Closed Meetings

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2010-12-28

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute of... Infectious Diseases Special Emphasis Panel. Development of Therapeutics Products for Biodefense. Date... 3126, MSC-7616, Bethesda, MD 20892-7616. 301-451-2671. [email protected] . Name of Committee...

76 FR 42720 - National Institute of Neurological Disorders and Stroke Notice of Closed Meeting

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2011-07-19

... Health, Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852 (Telephone Conference Call... Extramural Research, NINDS/ NIH/DHHS/Neuroscience Center, 6001 Executive Blvd., Suite 3208, MSC 9529... Disorders; 93.854, Biological Basis Research in the Neurosciences, National Institutes of Health, HHS) Dated...

77 FR 19024 - National Institute of Neurological Disorders and Stroke; Notice of Closed Meeting

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2012-03-29

... Disorders and Stroke Special Emphasis Panel; Diversity Research Education in Neuroscience. Date: April 18... Institutes of Health, Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852, (Telephone..., Division of Extramural Research, NINDS/ NIH/DHHS/Neuroscience Center, 6001 Executive Blvd., Suite 3208, MSC...

77 FR 20610 - Plant Variety Protection Board; Open Meeting

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2012-04-05

... Service [Document No. AMS-ST-12-0007] Plant Variety Protection Board; Open Meeting AGENCY: Agricultural... their opportunity to attend an open meeting of the Plant Variety Protection Board. DATES: April 25 and..., Beltsville, MD 20705. FOR FURTHER INFORMATION CONTACT: Jennifer Banks, Plant Variety Protection Office...

77 FR 7138 - Sunshine Act Meeting Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-10

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76 FR 75888 - National Institute of Biomedical Imaging and Bioengineering; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-05

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77 FR 35054 - Donald Brooks Reece II, M.D.; Dismissal of Proceeding

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2012-06-12

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75 FR 6675 - National Institute of Mental Health; Notice of Closed Meetings

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2010-02-10

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75 FR 13768 - National Institute of Neurological Disorders and Stroke; Notice of Closed Meetings

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2010-03-23

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77 FR 71605 - National Institute of Biomedical Imaging and Bioengineering; Notice of Closed Meetings

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2012-12-03

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76 FR 60508 - National Institute of Nursing Research; Notice of Closed Meeting

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2011-09-29

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78 FR 63996 - National Institute of Nursing Research; Notice of Closed Meeting

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2013-10-25

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Enterobius vermicularis infestation leading to Meckel's diverticulitis in an adolescent boy: An extremely rare presentation.

PubMed

Sharma, Manupriya; Kaul, Rashmi; Chander, Bal

2018-01-01

Enterobius vermicularis is an intestinal nematode commonly affecting children worldwide. Its transmission is by feco-oral route. Meckel's diverticulitis due to E. vermicularis infestation is an extremely rare presentation. An 11-year-old boy presented with acute abdomen. During surgery inflamed Meckel's diverticulum (M.D) was seen. Histopathology examination of specimen revealed E. vermicularis . Till date, only one case of E. vermicularis infestation of M.D is reported around five decades ago. This histopathological confirmation is extremely important as the required treatment (Mebendazole) of the infected case along with household contacts can prevent the spread of infection and may avoid surgery in known contacts.

Strong-Isospin-Breaking Correction to the Muon Anomalous Magnetic Moment from Lattice QCD at the Physical Point

NASA Astrophysics Data System (ADS)

Chakraborty, B.; Davies, C. T. H.; Detar, C.; El-Khadra, A. X.; Gámiz, E.; Gottlieb, Steven; Hatton, D.; Koponen, J.; Kronfeld, A. S.; Laiho, J.; Lepage, G. P.; Liu, Yuzhi; MacKenzie, P. B.; McNeile, C.; Neil, E. T.; Simone, J. N.; Sugar, R.; Toussaint, D.; van de Water, R. S.; Vaquero, A.; Fermilab Lattice, Hpqcd,; Milc Collaborations

2018-04-01

All lattice-QCD calculations of the hadronic-vacuum-polarization contribution to the muon's anomalous magnetic moment to date have been performed with degenerate up- and down-quark masses. Here we calculate directly the strong-isospin-breaking correction to aμHVP for the first time with physical values of mu and md and dynamical u , d , s , and c quarks, thereby removing this important source of systematic uncertainty. We obtain a relative shift to be applied to lattice-QCD results obtained with degenerate light-quark masses of δ aμHVP ,mu≠md=+1.5 (7 )% , in agreement with estimates from phenomenology.

7. Photocopy of photograph (original print in possession of Mary ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. Photocopy of photograph (original print in possession of Mary Lane Knott, 508 Central Avenue, Ridgely MD 21660). Photographer and date unknown, Circa 1900. VIEW EAST, SOUTHWEST FRONT, NORTHWEST SIDE Front and side elevations. Note the duplication of the recessed store front with display windows. Note the break in the original clapboard siding toward the rear on the Northwest side and the new clapboard siding near the buggy. Near the buggy wheel an original brick pier. Note the panelling below the display windows and the penny gumball machine on the wall marked 'Adams Tutti-Frutti'. - 510 Central Avenue (Commercial Building), Ridgely, Caroline County, MD

78 FR 66754 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-06

... Drive, Bethesda, MD 20892, (Virtual Meeting). Contact Person: Lynn E Luethke, Ph.D., Scientific Review... Scientific Review Special Emphasis Panel, Social Psychology, Personality and Interpersonal Processes Overflow...

Comparison of recovery parameters for xenon versus other inhalation anesthetics: systematic review and meta-analysis.

PubMed

Hou, Bingzong; Li, Fujing; Ou, Shanshan; Yang, Lukun; Zhou, Shaopeng

2016-03-01

To summarize and evaluate the available data describing the recovery parameters of xenon anesthesia. Systematic review and meta-analysis. Anesthesia for elective surgeries. Systematic review of randomized controlled trials (RCTs) from databases including Medline (1964-2013), the Cochrane Central Register of Controlled Trials (CENTRAL, 1990-2012), and Google Scholar (1966-2013). Inhalation of xenon or other anesthetics was administered in elective surgery. Recovery parameters (time to recovery, alertness/sedation scale scores at "eye opening," bispectral index at "reaction on demand," time to extubation, and time to orientation). Eleven RCTs (N = 661 patients) met the inclusion criteria. Recovery from xenon anesthesia was significantly faster in terms of the time to eye opening (mean difference [MD], -4.18 minutes; 95% confidence interval [CI], -5.03 to -3.32 minutes; P < .00001), the time to reaction on demand (MD, -5.35 minutes; 95% CI, -6.59 to -4.11 minutes; P < .00001), the time to extubation (MD, -4.49 minutes; 95% CI, -5.40 to -3.58 minutes; P < .00001), and the time to orientation (MD, -4.99 minutes; 95% CI, -6.45 to -3.52 minutes; P < .00001). This meta-analysis confirmed that recovery from xenon anesthesia is faster than other inhalation anesthesia. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

Incidental finding of carcinoid tumor on Meckel’s diverticulum: case report and literature review, should prophylactic resection be recommended?

PubMed Central

2014-01-01

Meckel’s diverticulum (MD) is the most common congenital anomaly of the gastrointestinal tract and is caused by incomplete obliteration of the vitelline duct during intrauterine life. MD affects less than 2% of the population. In most cases, MD is asymptomatic and the estimated average complication risk of MD carriers, which is inversely proportional to age, ranges between 2% and 4%. The most common MD-related complications are gastrointestinal bleeding, intestinal obstruction and acute phlogosis. Excision is mandatory in the case of symptomatic diverticula regardless of age, while surgical treatment for asymptomatic diverticula remains controversial. According to the majority of studies, the incidental finding of MD in children is an indication for surgical resection, while the management of adults is not yet unanimous. In this case report, we describe the prophylactic resection of an incidentally detected MD, which led to the removal of an occult mucosal carcinoid tumor. In literature, the association of MD and carcinoid tumor is reported as a rare finding. Even though the strategy for adult patients of an incidental finding of MD during surgery performed for other reasons divides the experts, we recommend prophylactic excision in order to avoid any further risk. PMID:24884768

76 FR 25701 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-05

... Person: David L Williams, PhD, Scientific Review Officer, Center for Scientific Review, National... Drive, Bethesda, MD 20892 (Virtual Meeting). Contact Person: Christine L. Melchior, PhD, Scientific...

Multivariate missing data in hydrology - Review and applications

NASA Astrophysics Data System (ADS)

Ben Aissia, Mohamed-Aymen; Chebana, Fateh; Ouarda, Taha B. M. J.

2017-12-01

Water resources planning and management require complete data sets of a number of hydrological variables, such as flood peaks and volumes. However, hydrologists are often faced with the problem of missing data (MD) in hydrological databases. Several methods are used to deal with the imputation of MD. During the last decade, multivariate approaches have gained popularity in the field of hydrology, especially in hydrological frequency analysis (HFA). However, treating the MD remains neglected in the multivariate HFA literature whereas the focus has been mainly on the modeling component. For a complete analysis and in order to optimize the use of data, MD should also be treated in the multivariate setting prior to modeling and inference. Imputation of MD in the multivariate hydrological framework can have direct implications on the quality of the estimation. Indeed, the dependence between the series represents important additional information that can be included in the imputation process. The objective of the present paper is to highlight the importance of treating MD in multivariate hydrological frequency analysis by reviewing and applying multivariate imputation methods and by comparing univariate and multivariate imputation methods. An application is carried out for multiple flood attributes on three sites in order to evaluate the performance of the different methods based on the leave-one-out procedure. The results indicate that, the performance of imputation methods can be improved by adopting the multivariate setting, compared to mean substitution and interpolation methods, especially when using the copula-based approach.

Multicomponent Lifestyle Interventions for Treating Overweight and Obesity in Children and Adolescents: A Systematic Review and Meta-Analyses

PubMed Central

Giske, L.; Fure, B.; Juvet, L. K.

2017-01-01

Background Treatment of childhood obesity is important in preventing development of obesity-related diseases later in life. This systematic review evaluates the effect of multicomponent lifestyle interventions for children and adolescents from 2 to 18 years. Methods and Results We performed systematic searches in nine databases. Thirty-nine studies met the criteria for meta-analyses. We found a significant difference in body mass index (BMI) after 6 months (MD −0.99 (95% CI −1.36 to −0.61)), 12 months (MD −0.67 (95% CI −1.01 to −0.32)), and 24 months (MD −0.96 (95% CI −1.63 to −0.29)) in favour of multicomponent lifestyle interventions compared to standard, minimal, and no treatment. We also found a significant difference in BMI Z scores after 6 months (MD −0.12 (95% CI −0.17 to −0.06)), 12 months (MD −0.16 (95% CI −0.21 to −0.11)), and 24 months (MD −0.16 (95% CI −0.21 to −0.10)) in favour of multicomponent lifestyle interventions. Subgroup analyses suggested an increased effect in specialist health care with a group treatment component included in the intervention. Conclusion Multicomponent lifestyle interventions have a moderate effect on change in BMI and BMI Z score after 6, 12, and 24 months compared with standard, minimal, and no treatment. PMID:29391949

Efficacy and Safety of Tai Chi for Parkinson's Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

PubMed Central

Ni, Xiaojia; Liu, Shaonan; Lu, Fuchang; Shi, Xiaogeng; Guo, Xinfeng

2014-01-01

Background and Objective In Parkinson's disease (PD), wearing off and side effects of long-term medication and complications pose challenges for neurologists. Although Tai Chi is beneficial for many illnesses, its efficacy for PD remains uncertain. The purpose of this review was to evaluate the efficacy and safety of Tai Chi for PD. Methods Randomized controlled trials (RCTs) of Tai Chi for PD were electronically searched by the end of December 2013 and identified by two independent reviewers. The tool from the Cochrane Handbook 5.1 was used to assess the risk of bias. A standard meta-analysis was performed using RevMan 5.2 software. Results Ten trials with PD of mild-to-moderate severity were included in the review, and nine trials (n = 409) were included in the meta-analysis. The risk of bias was generally high in the blinding of participants and personnel. Improvements in the Unified Parkinson's Disease Rating Scale Part III (mean difference (MD) −4.34, 95% confidence interval (CI) −6.67–−2.01), Berg Balance Scale (MD: 4.25, 95% CI: 2.83–5.66), functional reach test (MD: 3.89, 95% CI: 1.73–6.04), Timed Up and Go test (MD: −0.75, 95% CI: −1.30–−0.21), stride length (standardized MD: 0.56, 95% CI: 0.03–1.09), health-related quality of life (standardized MD: −1.10, 95% CI: −1.81–−0.39) and reduction of falls were greater after interventions with Tai Chi plus medication. Satisfaction and safety were high. Intervention with Tai Chi alone was more effective for only a few balance and mobility outcomes. Conclusions Tai Chi performed with medication resulted in promising gains in mobility and balance, and it was safe and popular among PD patients at an early stage of the disease. This provides a new evidence for PD management. More RCTs with larger sample size that carefully address blinding and prudently select outcomes are needed. PROSPERO registration number CRD42013004989. PMID:24927169

Review of 40-year MD theses in medical oncology.

PubMed

Zeeneldin, Ahmed; Diyaa, Amira; Moneer, Manar; Elgammal, Mosaad; Buhoush, Wafa

2014-09-01

It is almost 40 years since the foundation of the Medical Oncology (MO) Department. We aimed to appraise the clinical research to fulfill the Medical Doctorate (MD) degree in MO at the National Cancer Institute, Cairo University (NCI, CU). This review included 62 MD theses containing 66 studies. They were reviewed regarding aims, type of study, clinical trial phase, design and methodology, statistical tests, results, limitations, consent and IRB approval. Theses were grouped into 3 periods: 1970-1989, 1990-1999 and 2000-2008. Almost 76% of the studies were interventional and 24% were observational. Informed consent and Institutional Review Board approval were mentioned in 18 and 2 studies, respectively. While all studies mentioned the aims, none, clearly mentioned the research question. Outcomes were mainly efficacy followed by safety. Study design was inadequately considered, especially in 70's-80's period (p=0.038). Median sample size and study duration were almost stable through the three periods (p=0.441, 0.354, respectively). Most of the studies used both descriptive and analytical statistical methods. In a descending order, researched cancers were lymphoma, breast, leukemia, liver, urinary bladder, lung and colorectal. The commonest stages researched were IV and III. The number of studies focused on assessing biomarkers, biomarkers plus drugs/procedures, drugs and procedures are 20, 20, 16 and 6, respectively. With time, research within MD theses in MO increased quantitatively and qualitatively. Improvements were noticeable in documentation of study design. Copyright © 2014. Production and hosting by Elsevier B.V.

Canavan disease

MedlinePlus

... et al, eds. Swaiman's Pediatric Neurology: Principles and Practice . 6th ed. Philadelphia, PA: ... Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical ...

77 FR 60666 - Procedures for Assessment and Collection of Regulatory Fees; Assessment and Collection of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-04

... FEDERAL COMMUNICATIONS COMMISSION 47 CFR Part 1 [MD Docket No. 12-201; FCC 12-77] Procedures for... 2008 AGENCY: Federal Communications Commission. ACTION: Notice of proposed rulemaking; extension of reply comment date. SUMMARY: In this document, the Federal Communications Commission (Commission), via...

78 FR 35041 - National Institute on Aging; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-11

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute on Aging... personal privacy. Name of Committee: National Institute on Aging Special Emphasis Panel SWAN. Date: June 27... Institute on Aging, Gateway Building, Suite 2C212, 7201 Wisconsin Avenue, Bethesda, MD 20892, (Telephone...

77 FR 553 - Surety Companies Acceptable on Federal Bonds: Amendment-Evergreen National Indemnity Company

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-05

..., Financial Accounting and Services Division, Surety Bond Branch, 3700 East-West Highway, Room 6F01, Hyattsville, MD 20782. Dated: December 20, 2011. Laura Carrico, Director, Financial Accounting and Services...-- Evergreen National Indemnity Company AGENCY: Financial Management Service, Fiscal Service, Department of the...

77 FR 29472 - Surety Companies Acceptable on Federal Bonds-Termination: Atlantic Bonding Company, Inc.

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-17

..., Financial Accounting and Services Division, Surety Bond Branch, 3700 East-West Highway, Room 6F01, Hyattsville, MD 20782. Dated: May 8, 2012. Laura Carrico, Director, Financial Accounting and Services Division...--Termination: Atlantic Bonding Company, Inc. AGENCY: Financial Management Service, Fiscal Service, Department...

76 FR 82310 - Cardiovascular and Renal Drugs Advisory Committee; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-30

... (Parkinson's Disease, Multiple System Atrophy, and Pure Autonomic Failure), Dopamine Beta-Hydroxylase... recommendations to the Agency on FDA's regulatory issues. Date and Time: The meeting will be held on February 23... Colesville Rd., Silver Spring, MD 20910. The hotel's telephone number is (301) 589-5200. Contact Person...

75 FR 54157 - National Library of Medicine; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-03

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Library of Medicine... personal privacy. Name of Committee: National Library of Medicine Special Emphasis Panel; G08. Date... Library of Medicine, 6705 Rockledge Drive, Suite 301, Bethesda, MD 20892-7968, 301-496-4253, [email protected

77 FR 10540 - National Center for Complementary and Alternative Medicine Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-22

... Complementary and Alternative Medicine Notice of Closed Meeting Pursuant to section 10(d) of the Federal... Alternative Medicine Special Emphasis Panel; Research Resource for CAM Clinical Trials. Date: March 15, 2012... Alternative Medicine, National Institutes of Health, 6707 Democracy Boulevard, Suite 401, Bethesda, MD 20892...

1. Historic American Buildings Survey E.H. Pickering, Photographer Sept. 1936 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Historic American Buildings Survey E.H. Pickering, Photographer Sept. 1936 NOW FEDERAL PROPERTY BUILT AT VARIOUS TIMES AS LATE AS 1870? Note: Research tends to show buildings are of Post-Revolution date. - Catoctin Furnace, Stack No. 2, U. S. Route 15, Catoctin Furnace, Frederick County, MD

78 FR 70310 - National Institute of Neurological Disorders and Stroke; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-25

... Institute of Neurological Disorders and Stroke Special Emphasis Panel; Neuroscience Research Education (R25.... Place: National Institutes of Health, Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852... Research in the Neurosciences, National Institutes of Health, HHS). Dated: November 19, 2013. Carolyn Baum...

77 FR 38680 - NASA Advisory Council; Human Exploration and Operations Committee; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-28

... persons, scientific and technical information relevant to program planning. DATES: Monday, July 23, 2012... Goddard Space Flight Center (GSFC), Building 1, Room E100D, 8800 Greenbelt Road, Greenbelt, MD 20771. FOR... Session with the NAC Science Committee on Mars Program Planning Group and Joint Robotic Precursor...

76 FR 4927 - National Institute of Allergy and Infectious Diseases; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-27

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute of... Infectious Diseases Special Emphasis Panel; Partnership for Next Generation Biodefense Diagnostics. Date... Program, Room 3122, 6700- B Rockledge Drive, MSC-7616, Bethesda, MD 20892-7616, 301-451-3684, bgustafson...

78 FR 32307 - Art Advisory Panel-Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-29

... DEPARTMENT OF THE TREASURY Internal Revenue Service Art Advisory Panel--Notice of Closed Meeting AGENCY: Internal Revenue Service, Treasury. ACTION: Notice of closed meeting of Art Advisory Panel. SUMMARY: Closed meeting of the Art Advisory Panel will be held in Baltimore, MD. DATES: The meeting will...

78 FR 63996 - National Institute on Drug Abuse; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-25

... personal privacy. Name of Committee: National Institute on Drug Abuse Special Emphasis Panel; Quantification of Drugs of Abuse and Related Substances in Biological Specimens (7788). Date: November 7, 2013..., National Institute on Drug Abuse, NIH, DHHS, Room 4227, MSC 9550, 6001 Executive Boulevard, Bethesda, MD...

76 FR 81954 - National Institute on Drug Abuse; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-29

... personal privacy. Name of Committee: National Institute on Drug Abuse Special Emphasis Panel Confirming Compliance with Experimental Pharmacotherapy Treatment of Drug Abuse (2227) Date: January 17, 2012. Time: 9 a..., National Institute on Drug Abuse, NIH, DHHS, Room 4234, MSC 9550, 6001 Executive Blvd., Bethesda, MD 20892...

75 FR 67380 - National Institute of Neurological Disorders and Stroke; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-02

... Health, Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852. (Telephone Conference Call..., Division of Extramural Research, NINDS/NIH/DHHS, Neuroscience Center, 6001 Executive Blvd., Room 3204, MSC... Research in the Neurosciences, National Institutes of Health, HHS) Dated: October 27, 2010. Jennifer S...

75 FR 51279 - National Institute of Neurological Disorders and Stroke; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-19

... Branch, Division of Extramural Research, NINDS/NIH/DHHS, Neuroscience Center, 6001 Executive Blvd., Suite..., NINDS/ NIH/DHHS, Neuroscience Center, 6001 Executive Blvd., Suite 3208, MSC 9529, Bethesda, MD 20892... Neurosciences, National Institutes of Health, HHS) Dated: August 12, 2010. Jennifer Spaeth, Director, Office of...

75 FR 26647 - Implantation or Injectable Dosage Form New Animal Drugs; Ivermectin

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-12

... solution in cattle and swine for treatment and control of various internal and external parasites. DATES... Veterinary Medicine (HFV-170), Food and Drug Administration, 7500 Standish Pl., Rockville, MD 20855, 240-276... and swine for treatment and control of various internal and external parasites. Sparhawk Laboratories...

78 FR 3883 - Sunshine Act Meeting Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-17

... CONSUMER PRODUCT SAFETY COMMISSION Sunshine Act Meeting Notice TIME AND DATE: Wednesday, January 23, 2013, 10:00 a.m.--11:00 a.m. PLACE: Room 420, Bethesda Towers, 4330 East West Highway, Bethesda..., Office of the Secretary, U.S. Consumer Product Safety Commission, 4330 East West Highway, Bethesda, MD...

77 FR 53205 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-31

..., Bethesda, MD 20892, (Virtual Meeting). Contact Person: Fouad A El-Zaatari, Ph.D., Scientific Review Officer... Committee: Risk, Prevention and Health Behavior Integrated Review Group, Social Psychology, Personality and...

Herbal medicine for adults with asthma: A systematic review.

PubMed

Shergis, Johannah L; Wu, Lei; Zhang, Anthony L; Guo, Xinfeng; Lu, Chuanjian; Xue, Charlie C

2016-08-01

Many people with asthma use herbal medicines to help reduce symptoms and improve asthma control. To update the systematic review and meta-analysis of randomised controlled trials of herbal medicine for adult asthma. Nine English and Chinese databases were searched (PubMed, Embase, CINAHL, CENTRAL, AMED, CBM, CNKI, CQVIP, Wanfang). Herbal medicines combined with routine pharmacotherapies compared with the same pharmacotherapies alone or placebo. Cochrane Risk of Bias Tool and GRADE Summary of Findings tables were used to evaluate methodological quality. Twenty-nine (29) studies involving 3,001 participants were included. Herbal interventions used multi-ingredients such as licorice root, crow-dipper, astragali, and angelica. Compared with routine pharmacotherapies alone, herbal medicines as add-on therapy improved lung function (FEV1: MD 7.81%, 95% CI 5.79, 9.83, I(2) = 63%; PEFR: MD 65.14 L/min, 95% CI 58.87, 71.41, I(2) = 21%); asthma control (MD 2.47 points, 95% CI 1.64, 3.29, I(2) = 55%); reduced salbutamol usage (MD -1.14 puffs/day, 95% CI -2.20, -0.09, I(2) = 92%); and reduced acute asthma exacerbations over one year (MD -1.20, 95% CI -1.82, -0.58, one study). Compared with placebo plus pharmacotherapies herbal medicines as add-on therapy improved lung function (FEV1: MD 15.83%, 95% CI 13.54, 18.12 and PEFR: MD 55.20 L/min, 95% CI 33.41, 76.99). Other outcomes were not reported in these placebo studies. Included studies were low to moderate quality. Adverse events were rare. Herbal medicines combined with routine pharmacotherapies improved asthma outcomes greater than pharmacotherapies alone. Included studies did not blind participants therefore more studies that address such weaknesses are warranted.

77 FR 23166 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-18

... Aircraft System Component (JASC)/Air Transport Association (ATA) of America Code 28, Fuel. (e) Unsafe...-30F, MD-11, and MD-11F airplanes. This proposed AD was prompted by fuel system reviews conducted by... for fuel tank systems. As a result of those findings, we issued a regulation titled ``Transport...

75 FR 34661 - Airworthiness Directives; McDonnell Douglas Corporation Model DC-9-81 (MD-81), DC-9-82 (MD-82...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-18

... auxiliary fuel tanks, depending on the airplane configuration. This proposed AD results from fuel system... Fuel Tank System Design Review, Flammability Reduction and Maintenance and Inspection Requirements... substantiate that their fuel tank systems can prevent ignition sources in the fuel tanks. This requirement...

32 CFR 199.7 - Claims submission, review, and payment.

Code of Federal Regulations, 2011 CFR

2011-07-01

....g., M.D., Ph.D., R.N., etc.) and provider number, if the individual signing the claim is not the... rendering the care, along with the individual's professional status (e.g., M.D., Ph.D., R.N., etc.). (xi... the beneficiary's signature. (1) Claims for laboratory and diagnostic tests and test interpretations...

32 CFR 199.7 - Claims submission, review, and payment.

Code of Federal Regulations, 2013 CFR

2013-07-01

....g., M.D., Ph.D., R.N., etc.) and provider number, if the individual signing the claim is not the... rendering the care, along with the individual's professional status (e.g., M.D., Ph.D., R.N., etc.). (xi... the beneficiary's signature. (1) Claims for laboratory and diagnostic tests and test interpretations...

32 CFR 199.7 - Claims submission, review, and payment.

Code of Federal Regulations, 2012 CFR

2012-07-01

....g., M.D., Ph.D., R.N., etc.) and provider number, if the individual signing the claim is not the... rendering the care, along with the individual's professional status (e.g., M.D., Ph.D., R.N., etc.). (xi... the beneficiary's signature. (1) Claims for laboratory and diagnostic tests and test interpretations...

Neurobiological Underpinnings of Math and Reading Learning Disabilities

ERIC Educational Resources Information Center

Ashkenazi, Sarit; Black, Jessica M.; Abrams, Daniel A.; Hoeft, Fumiko; Menon, Vinod

2013-01-01

The primary goal of this review is to highlight current research and theories describing the neurobiological basis of math (MD), reading (RD), and comorbid math and reading disability (MD+RD). We first describe the unique brain and cognitive processes involved in acquisition of math and reading skills, emphasizing similarities and differences in…

76 FR 40923 - National Institute of Biomedical Imaging and Bioengineering; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-12

... assistance, such as sign language interpretation or other reasonable accommodations, should notify the..., Independence Room (2nd Level), Bethesda, MD 20817. Closed: 1 p.m. to 4 p.m. Agenda: To review and evaluate..., Independence Room (2nd Level), Bethesda, MD 20817 Contact Person: Anthony Demsey, PhD, Director, National...

75 FR 14175 - National Institute of Biomedical Imaging and Bioengineering; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-24

... assistance, such as sign language interpretation or other reasonable accommodations, should notify the... Level), Bethesda, MD 20817. Closed: 1:30 p.m. to 3 p.m. Agenda: To review and evaluate grant... (2nd Level), Bethesda, MD 20817. Contact Person: Anthony Demsey, PhD, Director, National Institute of...

White Feather: Fire Control and Crosswind Sensing for Sniper Applications

DTIC Science & Technology

2008-06-01

EAI Corp. P. Smoak – Weaponeering Study update • 1998 • SBIRS – SCTi, Brimrose , and Optical Air o February – OST Review at Ft...GROUND MD 21005-5066 1 B T HUAG 2314 TITAN TERRACE HAVRE DE GRACE MD 21078 1 BRIMROSE CORP ATTN S KUTCHER 19 LOVETON CIRCLE BALTIMORE

76 FR 53942 - Richard A. Herbert, M.D.; Decision and Order

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-30

... DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 09-33] Richard A. Herbert, M.D.; Decision and Order On June 15, 2010, Administrative Law Judge (ALJ) Mary Ellen Bittner issued the attached recommended decision. Thereafter, Respondent filed Exceptions to the ALJ's decision. Having reviewed the entire record including Respondent's...

Constructing high-accuracy intermolecular potential energy surface with multi-dimension Morse/Long-Range model

NASA Astrophysics Data System (ADS)

Zhai, Yu; Li, Hui; Le Roy, Robert J.

2018-04-01

Spectroscopically accurate Potential Energy Surfaces (PESs) are fundamental for explaining and making predictions of the infrared and microwave spectra of van der Waals (vdW) complexes, and the model used for the potential energy function is critically important for providing accurate, robust and portable analytical PESs. The Morse/Long-Range (MLR) model has proved to be one of the most general, flexible and accurate one-dimensional (1D) model potentials, as it has physically meaningful parameters, is flexible, smooth and differentiable everywhere, to all orders and extrapolates sensibly at both long and short ranges. The Multi-Dimensional Morse/Long-Range (mdMLR) potential energy model described herein is based on that 1D MLR model, and has proved to be effective and accurate in the potentiology of various types of vdW complexes. In this paper, we review the current status of development of the mdMLR model and its application to vdW complexes. The future of the mdMLR model is also discussed. This review can serve as a tutorial for the construction of an mdMLR PES.

Methemoglobinemia

MedlinePlus

... JI, Anastasi J, eds. Hematology: Basic Principles and Practice . 6th ed. Philadelphia, PA: Elsevier ... FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla ...

77 FR 8266 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-14

..., (Telephone Conference Call). Contact Person: Michael M. Sveda, Ph.D., Scientific Review Officer, Center for..., MD, Ph.D., Scientific Review Officer, Center for Scientific Review, National Institutes of Health...). Contact Person: Richard Panniers, Ph.D., Scientific Review Officer, Center for Scientific Review, National...

Trends in MD/PhD Graduates Entering Psychiatry: Assessing the Physician-Scientist Pipeline.

PubMed

Arbuckle, Melissa R; Luo, Sean X; Pincus, Harold Alan; Gordon, Joshua A; Chung, Joyce Y; Chavez, Mark; Oquendo, Maria A

2018-06-01

The goal of this study was to identify trends in MD/PhD graduates entering psychiatry, to compare these trends with other specialties, and to review strategies for enhancing the physician-scientist pipeline. Data on 226,588 medical students graduating from Liaison Committee on Medical Education accredited programs between 1999 and 2012 (6626 MD/PhDs) were used to evaluate the number, percentage, and proportion of MD/PhDs entering psychiatry in comparison with other specialties (neurology, neurosurgery, internal medicine, family medicine, and radiation oncology). Linear regression and multiple linear regression determined whether these values increased over time and varied by sex. Over 14 years, an average of 18 MD/PhDs (range 13-29) enrolled in psychiatry each year. The number of MD/PhDs going into psychiatry significantly increased, although these gains were modest (less than one additional MD/PhD per year). The proportion of students entering psychiatry who were MD/PhDs varied between 2.9 and 5.9 per 100 residents, with no significant change over time. There was also no change in the percentage of MD/PhDs entering psychiatry from among all MD/PhD graduates. The rate of increase in the number of MD/PhDs going into psychiatry did not differ significantly from other specialties except for family medicine, which is decreasing. The rate of MD/PhDs going into psychiatry was higher for women, suggesting closure of the sex gap in 17 years. Despite the increase in the number of MD/PhDs entering psychiatry, these numbers remain low. Expanding the cohort of physician-scientists dedicated to translational research in psychiatry will require a multipronged approach.

77 FR 1939 - National Institute of Allergy and Infectious Diseases; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-12

...: To review and evaluate grant applications. Place: Crowne Plaza Washington DC-Silver Spring, Silver Spring, MD 20910. Contact Person: B. Duane Price, Ph.D., Scientific Review Officer, Scientific Review...

Molecular Dynamics of Hot Dense Plasmas: New Horizons

NASA Astrophysics Data System (ADS)

Graziani, Frank

2011-06-01

We describe the status of a new time-dependent simulation capability for hot dense plasmas. The backbone of this multi-institutional computational and experimental effort--the Cimarron Project--is the massively parallel molecular dynamics (MD) code ``ddcMD''. The project's focus is material conditions such as exist in inertial confinement fusion experiments, and in many stellar interiors: high temperatures, high densities, significant electromagnetic fields, mixtures of high- and low- Z elements, and non-Maxwellian particle distributions. Of particular importance is our ability to incorporate into this classical MD code key atomic, radiative, and nuclear processes, so that their interacting effects under non-ideal plasma conditions can be investigated. This talk summarizes progress in computational methodology, discusses strengths and weaknesses of quantum statistical potentials as effective interactions for MD, explains the model used for quantum events possibly occurring in a collision and highlights some significant results obtained to date. We will also discuss a new idea called kinetic theory MD which now being explored to deal more efficiently with the very disparate dynamical timescales that arise in fusion plasmas. We discuss how this approach can be derived rigorously from the n-body quantum Wigner equation and illustrate the approach with an example. This work is performed under the auspices of the U. S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

Current activities and results of the Long Duration Exposure Facility Meteoroid and Debris Special Investigation Group

NASA Astrophysics Data System (ADS)

See, Thomas H.; Leago, Kimberly S.; Warren, Jack L.; Bernhard, Ronald P.; Zolensky, Michael E.

1994-03-01

Fiscal Year 1994 will bring to a close the initial investigative activities associated with the Long Duration Exposure Facility (LDEF). LDEF was a 14-faced spacecraft (i.e., 12-sided cylinder and two ends) which housed 54 different experimental packages in low-Earth orbit (LEO) from Apr. 1984 to Jan. 1990 (i.e., for approx. 5.75 years). Since LDEF's return, the Meteoroid & Debris Special Investigation Group (M&D SIG) has been examining various LDEF components in order to better understand and define the LEO particulate environment. Members of the M&D SIG at JSC in Houston, TX have been contributing to these studies by carefully examining and documenting all impact events found on LDEF's 6061-T6 aluminum Intercostals (i.e., one of the spacecraft's structural frame components). Unlike all other hardware on LDEF, the frame exposed significantly large surface areas of a single homogeneous material in all (i.e., 26) possible LDEF pointing directions. To date, 28 of the 68 Intercostals in the possession of the M&D SIG have been documented. This data, as well as similar information from various LDEF investigators, can be accessed through the M&D SIG Database which is maintained at JSC.

Current activities and results of the Long Duration Exposure Facility Meteoroid and Debris Special Investigation Group

NASA Technical Reports Server (NTRS)

See, Thomas H.; Leago, Kimberly S.; Warren, Jack L.; Bernhard, Ronald P.; Zolensky, Michael E.

1994-01-01

Fiscal Year 1994 will bring to a close the initial investigative activities associated with the Long Duration Exposure Facility (LDEF). LDEF was a 14-faced spacecraft (i.e., 12-sided cylinder and two ends) which housed 54 different experimental packages in low-Earth orbit (LEO) from Apr. 1984 to Jan. 1990 (i.e., for approx. 5.75 years). Since LDEF's return, the Meteoroid & Debris Special Investigation Group (M&D SIG) has been examining various LDEF components in order to better understand and define the LEO particulate environment. Members of the M&D SIG at JSC in Houston, TX have been contributing to these studies by carefully examining and documenting all impact events found on LDEF's 6061-T6 aluminum Intercostals (i.e., one of the spacecraft's structural frame components). Unlike all other hardware on LDEF, the frame exposed significantly large surface areas of a single homogeneous material in all (i.e., 26) possible LDEF pointing directions. To date, 28 of the 68 Intercostals in the possession of the M&D SIG have been documented. This data, as well as similar information from various LDEF investigators, can be accessed through the M&D SIG Database which is maintained at JSC.

Idiopathic hypersomnia

MedlinePlus

... Medicine, VA New Jersey Health Care System, Clinical Assistant Professor, Rutger's New Jersey Medical School, East Orange, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, ...

Ganglioneuroma

MedlinePlus

... Amit M. Shelat, DO, FACP, Attending Neurologist and Assistant Professor of Clinical Neurology, SUNY Stony Brook, School of Medicine. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, ...

Preparing MD-PhD students for clinical rotations: navigating the interface between PhD and MD training.

PubMed

Goldberg, Charles; Insel, Paul A

2013-06-01

Many aspects of MD-PhD training are not optimally designed to prepare students for their future roles as translational clinician-scientists. The transition between PhD research efforts and clinical rotations is one hurdle that must be overcome. MD-PhD students have deficits in clinical skills compared with those of their MD-only colleagues at the time of this transition. Reimmersion programs (RPs) targeted to MD-PhD students have the potential to help them navigate this transition.The authors draw on their experience creating and implementing an RP that incorporates multiple types of activities (clinical exam review, objective structured clinical examination, and supervised practice in patient care settings) designed to enhance the participants' skills and readiness for clinical efforts. On the basis of this experience, they note that MD-PhD students' time away from the clinical environment negatively affects their clinical skills, causing them to feel underprepared for clinical rotations. The authors argue that participation in an RP can help students feel more comfortable speaking with and examining patients and decrease their anxiety regarding clinical encounters. The authors propose that RPs can have positive outcomes for improving the transition from PhD to clinical MD training in dual-degree programs. Identifying and addressing this and other transitions need to be considered to improve the educational experience of MD-PhD students.

Threatened, Endangered, and at-Risk Species (TER-S) on Dod and Adjacent Lands Symposium and Workshop, Baltimore, MD, 7-9 June 2005

DTIC Science & Technology

2005-09-01

aware that notwithstanding any other provision of law, no person shall be subject to a penalty for failing to comply with a collection of information if...it does not display a currently valid OMB control number. 1. REPORT DATE 01 JUN 2005 2. REPORT TYPE N/ A 3. DATES COVERED - 4. TITLE AND...unlimited 13. SUPPLEMENTARY NOTES The original document contains color images. 14. ABSTRACT This report summarizes the results of a Symposium and

Parallelizing SHA-256, SHA-1 and MD5 and AES on the Cell Broadband Engine

DTIC Science & Technology

2010-10-25

job to SPU 5: wait for DONE signal from SPU 6: end while 7: send DONE signal to SPU Figure 4 : The PPU repeatedly tasks jobs to the SPU and consumes ...processors in IBM’s Cell Broadband Engine for Sony’s Playstation 3. Cryptology ePrint Archive, Report 2007/061, 2007. http://eprint.iacr.org/. [ 4 ] Owen...DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE (DD–MM–YYYY) 2. REPORT TYPE 3. DATES COVERED (From — To) 4 . TITLE AND SUBTITLE 5a

Molecular dynamics simulations and applications in computational toxicology and nanotoxicology.

PubMed

Selvaraj, Chandrabose; Sakkiah, Sugunadevi; Tong, Weida; Hong, Huixiao

2018-02-01

Nanotoxicology studies toxicity of nanomaterials and has been widely applied in biomedical researches to explore toxicity of various biological systems. Investigating biological systems through in vivo and in vitro methods is expensive and time taking. Therefore, computational toxicology, a multi-discipline field that utilizes computational power and algorithms to examine toxicology of biological systems, has gained attractions to scientists. Molecular dynamics (MD) simulations of biomolecules such as proteins and DNA are popular for understanding of interactions between biological systems and chemicals in computational toxicology. In this paper, we review MD simulation methods, protocol for running MD simulations and their applications in studies of toxicity and nanotechnology. We also briefly summarize some popular software tools for execution of MD simulations. Published by Elsevier Ltd.

Isolated sleep paralysis

MedlinePlus

... Medicine, VA New Jersey Health Care System, Clinical Assistant Professor, Rutgers New Jersey Medical School, East Orange, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, ...

77 FR 64131 - Zvi H. Perper, M.D., Decision and Order

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-18

... DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 11-34] Zvi H. Perper, M.D., Decision and Order On July 19, 2011, Administrative Law Judge (ALJ) Gail A. Randall issued the attached recommended decision. The Respondent did not file exceptions to the decision. Having reviewed the entire record, I have decided to adopt the ALJ's...

The effect of exercise training on clinical outcomes in patients with the metabolic syndrome: a systematic review and meta-analysis.

PubMed

Ostman, C; Smart, N A; Morcos, D; Duller, A; Ridley, W; Jewiss, D

2017-08-30

Purpose: to establish if exercise training improves clinical outcomes in people with metabolic syndrome (MetS). Registered with PROSPERO international prospective register of systematic reviews ( https://www.crd.york.ac.uk/PROSPERO/Identifier:CRD42017055491 ). studies were identified through a MEDLINE search strategy (1985 to Jan 12, 2017), Cochrane controlled trials registry, CINAHL and SPORTDiscus. prospective randomized or controlled trials of exercise training in humans with metabolic syndrome, lasting 12 weeks or more. We included 16 studies with 23 intervention groups; 77,000 patient-hours of exercise training. In analyses of aerobic exercise studies versus control: body mass index was significantly reduced, mean difference (MD) -0.29 (kg m -2 ) (95% CI -0.44, -0.15, p < 0.0001); body mass was significantly reduced, MD -1.16 kg (95% CI -1.83, -0.48, p = 0.0008); waist circumference was significantly reduced MD -1.37 cm (95% CI -2.02, -0.71, p < 0.0001), peak VO 2 was significantly improved MD 3.00 mL kg -1  min -1 (95% CI 1.92, 4.08, p < 0.000001); systolic blood pressure and diastolic blood pressure were significantly reduced, MD -2.54 mmHg (95% CI -4.34, -0.75, p = 0.006), and, MD -2.27 mmHg (95% CI -3.47, -1.06, p = 0.0002) respectively; fasting blood glucose was significantly reduced MD -0.16 mmol L -1 (95% CI -0.32, -0.01, p = 0.04); triglycerides were significantly reduced MD -0.21 mmol L -1 (95% CI -0.29, -0.13, p < 0.00001); and low density lipoprotein was significantly reduced MD -0.03 mmol L -1 (95% CI -0.05, -0.00, p = 0.02). In analyses of combined exercise versus control: waist circumference, MD -3.80 cm (95% CI -5.65, -1.95, p < 0.0001); peak VO 2 MD 4.64 mL kg -1  min -1 (95% CI 2.42, 6.87, p < 0.0001); systolic blood pressure MD -3.79 mmHg (95% CI -6.18, -1.40, p = 0.002); and high density lipoprotein (HDL) MD 0.14 (95% CI 0.04, 0.25, p = 0.009) were all significantly improved. We found no significant differences between outcome measures between the two exercise interventions. Exercise training improves body composition, cardiovascular, and, metabolic outcomes in people with metabolic syndrome. For some outcome measures, isolated aerobic exercise appears optimal.

Adherence to Mediterranean diet in relation to bone mineral density and risk of fracture: a systematic review and meta-analysis of observational studies.

PubMed

Malmir, Hanieh; Saneei, Parvane; Larijani, Bagher; Esmaillzadeh, Ahmad

2017-06-21

We aimed to systematically review available data on the association between adherence to MD and BMD as well as risk of fractures and to summarize this information through a meta-analysis. Previous studies in the field of adherence to MD in relation to BMD and risk of fracture were selected through searching PubMed, Scopus, ISI Web of Science and Google Scholar databases prior to June, 2016 using Mesh and non-Mesh relevant keywords. In the meta-analysis of four effect sizes, obtained from three studies, we found that adherence to MD was associated with a 21% reduced risk of hip fracture (overall RR 0.79; 95% CIs 0.72-0.87). Adherence to MD was positively associated with lumber spine ' s (mean difference of BMD comparing highest and lowest categories of MD score 0.12; 95% CI 0.06-0.19 g/cm 2 ), femoral neck (0.10; 0.06-0.15 g/cm 2 ) and total hip (0.11; 0.09-0.14 g/cm 2 ) BMD. Meta-regression of included observational studies revealed a significant inverse linear association between Mediterranean diet score and risk of hip fracture, such that one unit increase in the score of Mediterranean diet was associated with a reduction in the risk of hip fracture (RR 0.95, 95% CI 0.92-0.98 p = 0.01). Adherence to MD was associated with a reduced risk of fracture as well as with a higher mean BMD.

75 FR 10172 - Drawbridge Operation Regulation; Chester River, Chestertown, MD

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-05

... to the anticipated infrequency of requests for vessel openings of the drawbridge. DATES: This rule is... openings year-round due to the anticipated infrequency of requests for vessel openings of the drawbridge... shall open on signal if at least six hours notice is given. Bridge opening data, supplied by MDOT...

76 FR 60059 - National Institute of General Medical Sciences; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-28

... General Medical Sciences; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory... Sciences Special Emphasis Panel, Research Centers in Wound Healing. Date: October 19, 2011. Time: 12 p.m... General Medical Sciences, National Institutes of Health, 45 Center Drive, Room 3AN18, Bethesda, MD 20892...

75 FR 49992 - Peter W.S. Grigg, M.D.; Revocation of Registration

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-16

... denial of any pending application to renew or modify the registration on the ground that his ``continued... also unlawfully distributed four fentanyl 400 mg. tablets and one fentanyl transdermal patch 12 mcg./hr... legitimate medical purposes.'' Id. Respondent also admitted that on this date, he distributed to the officer...

77 FR 11195 - Surety Companies Acceptable on Federal Bonds-Name Change and Change in State of Incorporation...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-24

..., Financial Management Service, Financial Accounting and Services Division, Surety Bond Branch, 3700 East-West Highway, Room 6F01, Hyattsville, MD 20782. Dated: February 15, 2012. Laura Carrico, Director, Financial... Change and Change in State of Incorporation: Nations Bonding Company AGENCY: Financial Management Service...

77 FR 76056 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-26

... Blood Institute; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee... Blood Institute Special Emphasis Panel; NHLBI CARDIA Echo & Field Centers. Date: January 16, 2013. Time... Blood Institute, 6701 Rockledge Drive, Room 7184, Bethesda, MD 20892-7924, 301-435-0277, [email protected

75 FR 42100 - National Center on Minority and Health Disparities; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-20

... and Health Disparities; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory... and Health Disparities Special Emphasis Panel, NCMHD Social Determinants of Health (R01) Panel. Date... Disparities, 6707 Democracy Boulevard, Suite 800, Bethesda, MD 20892, (301) 594-8696, [email protected

77 FR 13522 - Safety Zone; Baltimore Air Show, Patapsco River, Baltimore, MD

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-07

... Register. Background and Purpose The U.S. Navy History & Heritage Command, Office of Commemorations, is... public event will consist of military and civilian aircraft performing low-flying, high-speed precision... Harbor. In addition to the air show dates, military and civilian aircraft performing in the air show will...

75 FR 13137 - National Center For Complementary and Alternative Medicine; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-18

... Complementary and Alternative Medicine; Notice of Closed Meeting Pursuant to section 10(d) of the Federal... Alternative Medicine Special Emphasis Panel; International Center for Research in CAM. Date: April 12, 2010... Complementary and Alternative Medicine, NIH, 6707 Democracy Blvd., Suite 401, Bethesda, MD 20892, (301) 451-6570...

Temperature and Concentration Profiles in Hydrogen-Nitrous Oxide Flames.

DTIC Science & Technology

1986-07-01

SECumvY CLASSIFICATION CF TIS PAGOE(hn Date. 3.,OCO 20. Abstract (Cont’d): est for flame modeler UNCLASSIFIED * SECURITY CL ASSIrIC ATION Or THIS P...Commander Naval Surface Weapons Center Commander ATTN: R. Bernecker, R-13 US Army Tank Automotive G.B. Wilmot , R-16 Command Silver Spring, MD 20902

77 FR 26301 - National Cancer Institute; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-03

....396, Cancer Biology Research; 93.397, Cancer Centers Support; 93.398, Cancer Research Manpower; 93.399..., MD 20892 (Telephone Conference Call). Contact Person: Virginia P. Wray, Ph.D., Deputy Chief, Research... Special Emphasis Panel; Cell-Based Imaging. Date: June 19, 2012. Time: 1:00 p.m. to 4:00 p.m. Agenda: To...

Maintaining the Marine Corps’ Tank Dominant Combat Overmatch in an Uncertain Future

DTIC Science & Technology

2012-03-12

Company, 1999), 6. 2 2011 Tank Conference Report. (Dated 02 Feb 2011) 3 Kenneth E. Estes. Marines Under Armor : The Marine Corps and the Armored...Kenneth W. Marines Under Armor : The Marine Corps and the Armored Fighting Vehicle, 1916-2000. Annapolis, MD: Naval Institute Press, 2000. Ford

75 FR 18056 - Safety Zone; Fireworks Display, Patuxent River, Solomons Island Harbor, MD

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-09

..., DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary safety zone... necessary to provide for the safety of life on navigable waters during a fireworks display launched from... protect the maritime public in a portion of Solomons Island Harbor. DATES: This rule is effective from 7...

76 FR 19999 - Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-11

... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel, Cognitive Development. Date: April... Institute of Child Health and Human Development, 6100 Executive Boulevard, Rockville, MD 20892-9304, (301...

78 FR 17679 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-22

... Arthritis and Musculoskeletal and Skin Diseases; Closed Meeting Pursuant to section 10(d) of the Federal... Musculoskeletal and Skin Diseases Special Emphasis Panel; NIAMS Clinical Trial Outcome Development. Date: March 29..., Musculoskeletal and Skin Diseases, NIH, 6701 Democracy Boulevard, Suite 800, Bethesda, MD 20892, 301-594-4953...

78 FR 68460 - Draft Guidance for Industry on Frequently Asked Questions About Medical Foods; Second Edition...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-14

... interested persons additional time to submit comments. DATES: Submit either electronic or written comments by....gov . Submit written comments to the Division of Dockets Management (HFA-305), Food and Drug... Branch Pkwy., College Park, MD 20740, 240-402-1783. SUPPLEMENTARY INFORMATION: I. Background In the...

75 FR 11895 - National Institute of General Medical Sciences; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-12

... confidential trade secrets or commercial property such as patentable material, and personal information... Sciences Special Emphasis Panel, Modeling the Scientific Workforce. Date: April 5, 2010. Time: 1 p.m. to 3..., Natcher Building, 45 Center Drive, Room 3AN.34, Bethesda, MD 20892. Contact Person: Brian R. Pike, PhD...

77 FR 19004 - Fishing Capacity Reduction Program for the Southeast Alaska Purse Seine Salmon Fishery

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-29

... Capacity Reduction Program for the Southeast Alaska Purse Seine Salmon Fishery AGENCY: National Marine... Salmon Fishery. DATES: Comments must be submitted on or before 5 p.m. EST April 13, 2012. ADDRESSES: Send... Seine Salmon Buyback, 1315 East-West Highway, Silver Spring, MD 20910 (see FOR FURTHER INFORMATION...

Soft tissue changes following extraction vs. nonextraction orthodontic fixed appliance treatment: a systematic review and meta-analysis.

PubMed

Konstantonis, Dimitrios; Vasileiou, Dimitrios; Papageorgiou, Spyridon N; Eliades, Theodore

2018-06-01

The aim of this systematic review was to assess the effect of systematic extraction protocols during orthodontic fixed appliance treatment on the soft tissue profile of human patients. Nine databases were searched until December 2016 for controlled clinical studies including premolar extraction or nonextraction treatment. After elimination of duplicate studies, data extraction, and risk-of-bias assessment according to the Cochrane guidelines, random-effects meta-analyses of mean differences (MD) or standardized mean differences (SMD) and their 95% CIs were performed, followed by subgroup, meta-regression, and sensitivity analyses. Extraction treatment was associated with increased lower lip retraction (24 studies; 1,456 patients; MD = 1.96 mm), upper lip retraction (21 studies; 1,149 patients; MD = 1.26 mm), nasolabial angle (21 studies; 1,089 patients; MD = 4.21°), soft-tissue profile convexity (six studies; 408 patients; MD = 1.24°), and profile pleasantness (three studies; 249 patients; SMD = 0.41). Patient age, extraction protocol, and amount of upper incisor retraction during treatment were significantly associated with the observed extraction effects, while the quality of evidence was very low in all cases due to risk of bias, baseline confounding, inconsistency, and imprecision. Although tooth extractions seem to affect patient profile, existing studies are heterogenous and no consistent predictions of profile response can be made. © 2018 Eur J Oral Sci.

[Dietetic factors associated with prostate cancer: protective effects of Mediterranean diet].

PubMed

Ferrís-Tortajada, J; Berbel-Tornero, O; García-Castell, J; Ortega-García, J A; López-Andreu, J A

2012-04-01

To review diet risk factors (RF) implied, more or less evidence-based, in the etiopathology of prostate carcinoma (PC), especially those that characterize the traditional Mediterranean diet (MD). Literature review of PC related diet RF in MedLine, CancerLit, Science Citation Index y Embase. Search profiles were "Dietetic Factors/Nutritional Factors/Mediterranean Diet/Primary Prevention", and "Prostate Cancer". Diet RF are associated with 35% of cancer mortality and 10-12% of PC mortality. The main diet RF, implied in the development of PC but with a protective effect, which are considered characteristic of MD are: high daily ingestion of vegetarian products (cereals, legumes, dried and fresh fruits, tubers, vegetables..); olive oil as main lipid source; low intake of animal saturated fat, processed red meat, milk and dairy products; regular consumption of small fish; and low alcohol intake (wine with meals). The MD contains many phytoactive compounds (lycopene, lupeol, quercetin, genistein, carnosol, resveratrol, catechins, vitamins..) with PC protective effects. Diet RF have a role on prostatic carcinogenesis. Further epidemiologic studies with better designs are needed to clarify PC related diet RF. PC risk is reduced in persons on MD compared with those on Western diet. The preventive effect of MD is due to the great number and quality of phytochemicals with antioxidant and antinflammatory properties that contains. Copyright © 2011 AEU. Published by Elsevier Espana. All rights reserved.

75 FR 32956 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-10

... Center, 5701 Marinelli Road, Bethesda, MD 20852. Contact Person: Joanna M. Pyper, PhD, Scientific Review...: Yi-Hsin Liu, PhD, Scientific Review Officer, Center for Scientific Review, National Institutes of... . Name of Committee: Center for Scientific Review Special Emphasis Panel, RFA-DA-10-017: Seek, Test, and...

76 FR 1622 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-11

...: Risk, Prevention and Health Behavior Integrated Review Group; Social Psychology, Personality and.... Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892, (Virtual Meeting...

Cavernous sinus thrombosis

MedlinePlus

... Amit M. Shelat, DO, FACP, Attending Neurologist and Assistant Professor of Clinical Neurology, SUNY Stony Brook, School of Medicine. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, ...

Subacute sclerosing panencephalitis

MedlinePlus

... Amit M. Shelat, DO, FACP, Attending Neurologist and Assistant Professor of Clinical Neurology, SUNY Stony Brook, School of Medicine. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, ...

78 FR 39298 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-01

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review...., Scientific Review Officer, Center for Scientific Review, National Institutes of Health, 6701 Rockledge Drive...: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892, (Virtual Meeting). Contact Person...

78 FR 8157 - National Cancer Institute; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-05

... Person: Donald L Coppock, Ph.D., Scientific Review Officer, Special Review and Logistics Branch, Division... Marriott Hotel & Conference Center, 5701 Marinelli Road, Bethesda, MD 20852. Contact Person: Ellen K Schwartz, EDD, Scientific Review Officer, Special Review and Logistics Branch, Division of Extramural...

78 FR 55750 - National Cancer Institute; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-11

..., Cancer Centers Support; 93.398, Cancer Research Manpower; 93.399, Cancer Control, National Institutes of.... Contact Person: Caterina Bianco, MD, Ph.D., Scientific Review Officer, Research Programs Review Branch...: David G. Ransom, Ph.D., Scientific Review Officer, Research Programs Review Branch, Division of...

A Review of Enhanced Sampling Approaches for Accelerated Molecular Dynamics

NASA Astrophysics Data System (ADS)

Tiwary, Pratyush; van de Walle, Axel

Molecular dynamics (MD) simulations have become a tool of immense use and popularity for simulating a variety of systems. With the advent of massively parallel computer resources, one now routinely sees applications of MD to systems as large as hundreds of thousands to even several million atoms, which is almost the size of most nanomaterials. However, it is not yet possible to reach laboratory timescales of milliseconds and beyond with MD simulations. Due to the essentially sequential nature of time, parallel computers have been of limited use in solving this so-called timescale problem. Instead, over the years a large range of statistical mechanics based enhanced sampling approaches have been proposed for accelerating molecular dynamics, and accessing timescales that are well beyond the reach of the fastest computers. In this review we provide an overview of these approaches, including the underlying theory, typical applications, and publicly available software resources to implement them.

76 FR 58522 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-21

...: Ai-Ping Zou, MD, PhD, Scientific Review Officer, Center for Scientific Review, National Institutes of... Nos. 93.306, Comparative Medicine; 93.333, Clinical Research, 93.306, 93.333, 93.337, 93.393-93.396...

Convulsions - first aid - slideshow

MedlinePlus

... Amit M. Shelat, DO, FACP, attending neurologist and Assistant Professor of Clinical Neurology, SUNY Stony Brook, School of Medicine. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, ...

Why should biochemistry students be introduced to molecular dynamics simulations--and how can we introduce them?

PubMed

Elmore, Donald E

2016-01-01

Molecular dynamics (MD) simulations play an increasingly important role in many aspects of biochemical research but are often not part of the biochemistry curricula at the undergraduate level. This article discusses the pedagogical value of exposing students to MD simulations and provides information to help instructors consider what software and hardware resources are necessary to successfully introduce these simulations into their courses. In addition, a brief review of the MD-based activities in this issue and other sources are provided. © 2016 The International Union of Biochemistry and Molecular Biology.

77 FR 74675 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-17

... Rockledge Drive, Bethesda, MD 20892, (Telephone Conference Call). Contact Person: Rajiv Kumar, Ph.D., Chief... Chaudhari, Ph.D., Scientific Review Officer, Center for Scientific Review, National Institutes of Health... Conference Call). Contact Person: Syed M Quadri, Ph.D., Scientific Review Officer, Center for Scientific...

76 FR 60058 - Center for Scientific Review; Notice of Closed Meetings

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2011-09-28

... for Scientific Review Special Emphasis Panel, RFA Panel: Understanding and Promoting Health Literacy... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... Review, National Institutes of Health, 6701 Rockledge Drive, Room 4140, MSC 7814, Bethesda, MD 20892, 301...

77 FR 35415 - Center for Scientific Review; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-13

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... Review, National Institutes of Health, 6701 Rockledge Drive, Room 5182, MSC 7844, Bethesda, MD 20892... for Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Room 5216, MSC 7852...

Venogram

MedlinePlus

... PhD, Department of Surgery, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A. ...

75 FR 13767 - Center for Scientific Review; Notice of Closed Meetings

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2010-03-23

... Rockledge Drive, Room 5218, MSC 7852, Bethesda, MD 20892, 301-435- 1775, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by..., Bethesda, MD 20892, 301-435- 4514, [email protected]csr.nih.gov . This notice is being published less than 15 days...

Towards fast, rigorous and efficient conformational sampling of biomolecules: Advances in accelerated molecular dynamics.

PubMed

Doshi, Urmi; Hamelberg, Donald

2015-05-01

Accelerated molecular dynamics (aMD) has been proven to be a powerful biasing method for enhanced sampling of biomolecular conformations on general-purpose computational platforms. Biologically important long timescale events that are beyond the reach of standard molecular dynamics can be accessed without losing the detailed atomistic description of the system in aMD. Over other biasing methods, aMD offers the advantages of tuning the level of acceleration to access the desired timescale without any advance knowledge of the reaction coordinate. Recent advances in the implementation of aMD and its applications to small peptides and biological macromolecules are reviewed here along with a brief account of all the aMD variants introduced in the last decade. In comparison to the original implementation of aMD, the recent variant in which all the rotatable dihedral angles are accelerated (RaMD) exhibits faster convergence rates and significant improvement in statistical accuracy of retrieved thermodynamic properties. RaMD in conjunction with accelerating diffusive degrees of freedom, i.e. dual boosting, has been rigorously tested for the most difficult conformational sampling problem, protein folding. It has been shown that RaMD with dual boosting is capable of efficiently sampling multiple folding and unfolding events in small fast folding proteins. RaMD with the dual boost approach opens exciting possibilities for sampling multiple timescales in biomolecules. While equilibrium properties can be recovered satisfactorily from aMD-based methods, directly obtaining dynamics and kinetic rates for larger systems presents a future challenge. This article is part of a Special Issue entitled Recent developments of molecular dynamics. Copyright © 2014 Elsevier B.V. All rights reserved.

Wheelchair tiedown and occupant restraint practices in paratransit vehicles

PubMed Central

Smalley, Craig

2018-01-01

The purpose of this study was to characterize wheelchair tiedown and occupant restraint system (WTORS) usage in paratransit vehicles based on observations of wheelchair and scooter (wheeled mobility devices, collectively, “WhMD”) passenger trips. A retrospective review of on-board video monitoring recordings of WhMD trips was conducted. Four hundred seventy-five video recordings were collected for review and analysis. The use of all four tiedowns to secure the WhMD was observed more frequently for power WhMDs (82%) and manual WhMDs (80%) compared to scooters (39%), and this difference was significant (p< 0.01). Nonuse or misuse of the occupant restraint system occurred during 88% of WhMD trips, and was most frequently due to vehicle operator neglect in applying the shoulder belt. Despite the absence of incidents or injuries in this study, misuse and nonuse of WTORS potentially place WhMD seated passengers at higher risk of injury during transit. These findings support the need for improved vehicle operator training and passenger education on the proper use of WTORS and development of WTORS with improved usability and/or alternative technologies that can be automated or used independently. PMID:29304035

75 FR 54893 - Center for Scientific Review; Notice of Closed Meetings

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2010-09-09

... 7850, Bethesda, MD 20892. 301-435-3009. [email protected] . Name of Committee: Molecular, Cellular and Developmental Neuroscience Integrated Review Group, Molecular Neuropharmacology and Signaling... . Name of Committee: Emerging Technologies and Training Neurosciences Integrated Review Group, Molecular...

78 FR 3905 - Center for Scientific Review; Notice of Closed Meetings

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2013-01-17

... . Name of Committee: Cardiovascular and Respiratory Sciences Integrated Review Group; Cardiac... 3188, MSC 7808, Bethesda, MD 20892, 301-435- 1146, [email protected] . Name of Committee: Cardiovascular and Respiratory Sciences Integrated Review Group; Clinical and Integrative Cardiovascular Sciences...

Specific learning disability in mathematics: a comprehensive review.

PubMed

Soares, Neelkamal; Evans, Teresa; Patel, Dilip R

2018-01-01

Math skills are necessary for success in the childhood educational and future adult work environment. This article reviews the changing terminology for specific learning disabilities (SLD) in math and describes the emerging genetics and neuroimaging studies that relate to individuals with math disability (MD). It is important to maintain a developmental perspective on MD, as presentation changes with age, instruction, and the different models (educational and medical) of identification. Intervention requires a systematic approach to screening and remediation that has evolved with more evidence-based literature. Newer directions in behavioral, educational and novel interventions are described.

Specific learning disability in mathematics: a comprehensive review

PubMed Central

Evans, Teresa; Patel, Dilip R.

2018-01-01

Math skills are necessary for success in the childhood educational and future adult work environment. This article reviews the changing terminology for specific learning disabilities (SLD) in math and describes the emerging genetics and neuroimaging studies that relate to individuals with math disability (MD). It is important to maintain a developmental perspective on MD, as presentation changes with age, instruction, and the different models (educational and medical) of identification. Intervention requires a systematic approach to screening and remediation that has evolved with more evidence-based literature. Newer directions in behavioral, educational and novel interventions are described. PMID:29441282

Molecular dynamics-driven drug discovery: leaping forward with confidence.

PubMed

Ganesan, Aravindhan; Coote, Michelle L; Barakat, Khaled

2017-02-01

Given the significant time and financial costs of developing a commercial drug, it remains important to constantly reform the drug discovery pipeline with novel technologies that can narrow the candidates down to the most promising lead compounds for clinical testing. The past decade has witnessed tremendous growth in computational capabilities that enable in silico approaches to expedite drug discovery processes. Molecular dynamics (MD) has become a particularly important tool in drug design and discovery. From classical MD methods to more sophisticated hybrid classical/quantum mechanical (QM) approaches, MD simulations are now able to offer extraordinary insights into ligand-receptor interactions. In this review, we discuss how the applications of MD approaches are significantly transforming current drug discovery and development efforts. Copyright © 2016 Elsevier Ltd. All rights reserved.

78 FR 7438 - Center for Scientific Review; Notice of Closed Meetings

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2013-02-01

..., 6701 Rockledge Drive, Bethesda, MD 20892, (Telephone Conference Call). Contact Person: Lisa Steele, Ph..., CA 90405. Contact Person: Valerie Durrant, Ph.D., Scientific Review Officer, Center for Scientific...

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2011-09-09

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78 FR 312 - Center for Scientific Review; Notice of Closed Meetings

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2013-01-03

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75 FR 78716 - Center for Scientific Review; Notice of Closed Meetings

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2010-12-16

... 4114, MSC 7816, Bethesda, MD 20892. (301) 435- 1782. [email protected] . Name of Committee: Oncology... Committee: Oncology 2--Translational Clinical Integrated Review Group. Basic Mechanisms of Cancer...

Gastroschisis repair

MedlinePlus

... PhD, Department of Surgery, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A. ...

Omphalocele repair

MedlinePlus

... PhD, Department of Surgery, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A. ...

Extremity angiography

MedlinePlus

... PhD, Department of Surgery, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A. ...

Probiotics Supplementation Therapy for Pathological Neonatal Jaundice: A Systematic Review and Meta-Analysis

PubMed Central

Chen, Zhe; Zhang, Lingli; Zeng, Linan; Yang, Xiaoyan; Jiang, Lucan; Gui, Ge; Zhang, Zuojie

2017-01-01

Background: Neonatal jaundice is a relatively prevalent disease and affects approximately 2.4–15% newborns. Probiotics supplementation therapy could assist to improve the recovery of neonatal jaundice, through enhancing immunity mainly by regulating bacterial colonies. However, there is limited evidence regarding the effect of probiotics on bilirubin level in neonates. Therefore, this study aims at systematically evaluating the efficacy and safety of probiotics supplement therapy for pathological neonatal jaundice. Methods: Databases including PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wan Fang Database (Wan Fang), Chinese Biomedical Literature Database (CBM), VIP Database for Chinese Technical Periodicals (VIP) were searched and the deadline is December 2016. Randomized controlled trials (RCTs) of probiotics supplementation for pathological neonatal jaundice in publications were extracted by two reviewers. The cochrane tool was applied to assessing the risk of bias of the trials. The extracted information of RCTs should include efficacy rate, serum total bilirubin level, time of jaundice fading, duration of phototherapy, duration of hospitalization, adverse reactions. The main outcomes of the trials were analyzed by Review Manager 5.3 software. The relative risks (RR) or mean difference (MD) with a 95% confidence interval (CI) was used to measure the effect. Results: 13 RCTs involving 1067 neonatal with jaundice were included in the meta-analysis. Probiotics supplementation treatment showed efficacy [RR: 1.19, 95% CI (1.12, 1.26), P < 0.00001] in neonatal jaundice. It not only decreased the total serum bilirubin level after 3day [MD: −18.05, 95% CI (−25.51, −10.58), P < 0.00001], 5day [MD: -23.49, 95% CI (−32.80, −14.18), P < 0.00001], 7day [MD: −33.01, 95% CI (−37.31, −28.70), P < 0.00001] treatment, but also decreased time of jaundice fading [MD: −1.91, 95% CI (−2.06, −1.75), P < 0.00001], as well as the duration of phototherapy [MD: −0.64, 95% CI (−0.84, −0.44), P < 0.00001] and hospitalization [MD: −2.68, 95% CI (−3.18, −2.17), P < 0.00001], when compared with the control group. Additionally, no serious adverse reaction was reported. Conclusion: This meta-analysis shows that probiotics supplementation therapy is an effective and safe treatment for pathological neonatal jaundice. PMID:28713275

Probiotics Supplementation Therapy for Pathological Neonatal Jaundice: A Systematic Review and Meta-Analysis.

PubMed

Chen, Zhe; Zhang, Lingli; Zeng, Linan; Yang, Xiaoyan; Jiang, Lucan; Gui, Ge; Zhang, Zuojie

2017-01-01

Background: Neonatal jaundice is a relatively prevalent disease and affects approximately 2.4-15% newborns. Probiotics supplementation therapy could assist to improve the recovery of neonatal jaundice, through enhancing immunity mainly by regulating bacterial colonies. However, there is limited evidence regarding the effect of probiotics on bilirubin level in neonates. Therefore, this study aims at systematically evaluating the efficacy and safety of probiotics supplement therapy for pathological neonatal jaundice. Methods: Databases including PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wan Fang Database (Wan Fang), Chinese Biomedical Literature Database (CBM), VIP Database for Chinese Technical Periodicals (VIP) were searched and the deadline is December 2016. Randomized controlled trials (RCTs) of probiotics supplementation for pathological neonatal jaundice in publications were extracted by two reviewers. The cochrane tool was applied to assessing the risk of bias of the trials. The extracted information of RCTs should include efficacy rate, serum total bilirubin level, time of jaundice fading, duration of phototherapy, duration of hospitalization, adverse reactions. The main outcomes of the trials were analyzed by Review Manager 5.3 software. The relative risks (RR) or mean difference (MD) with a 95% confidence interval (CI) was used to measure the effect. Results: 13 RCTs involving 1067 neonatal with jaundice were included in the meta-analysis. Probiotics supplementation treatment showed efficacy [RR: 1.19, 95% CI (1.12, 1.26), P < 0.00001] in neonatal jaundice. It not only decreased the total serum bilirubin level after 3day [MD: -18.05, 95% CI (-25.51, -10.58), P < 0.00001], 5day [MD: -23.49, 95% CI (-32.80, -14.18), P < 0.00001], 7day [MD: -33.01, 95% CI (-37.31, -28.70), P < 0.00001] treatment, but also decreased time of jaundice fading [MD: -1.91, 95% CI (-2.06, -1.75), P < 0.00001], as well as the duration of phototherapy [MD: -0.64, 95% CI (-0.84, -0.44), P < 0.00001] and hospitalization [MD: -2.68, 95% CI (-3.18, -2.17), P < 0.00001], when compared with the control group. Additionally, no serious adverse reaction was reported. Conclusion: This meta-analysis shows that probiotics supplementation therapy is an effective and safe treatment for pathological neonatal jaundice.

Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis

PubMed Central

Rossignol, D A; Frye, R E

2012-01-01

A comprehensive literature search was performed to collate evidence of mitochondrial dysfunction in autism spectrum disorders (ASDs) with two primary objectives. First, features of mitochondrial dysfunction in the general population of children with ASD were identified. Second, characteristics of mitochondrial dysfunction in children with ASD and concomitant mitochondrial disease (MD) were compared with published literature of two general populations: ASD children without MD, and non-ASD children with MD. The prevalence of MD in the general population of ASD was 5.0% (95% confidence interval 3.2, 6.9%), much higher than found in the general population (∼0.01%). The prevalence of abnormal biomarker values of mitochondrial dysfunction was high in ASD, much higher than the prevalence of MD. Variances and mean values of many mitochondrial biomarkers (lactate, pyruvate, carnitine and ubiquinone) were significantly different between ASD and controls. Some markers correlated with ASD severity. Neuroimaging, in vitro and post-mortem brain studies were consistent with an elevated prevalence of mitochondrial dysfunction in ASD. Taken together, these findings suggest children with ASD have a spectrum of mitochondrial dysfunction of differing severity. Eighteen publications representing a total of 112 children with ASD and MD (ASD/MD) were identified. The prevalence of developmental regression (52%), seizures (41%), motor delay (51%), gastrointestinal abnormalities (74%), female gender (39%), and elevated lactate (78%) and pyruvate (45%) was significantly higher in ASD/MD compared with the general ASD population. The prevalence of many of these abnormalities was similar to the general population of children with MD, suggesting that ASD/MD represents a distinct subgroup of children with MD. Most ASD/MD cases (79%) were not associated with genetic abnormalities, raising the possibility of secondary mitochondrial dysfunction. Treatment studies for ASD/MD were limited, although improvements were noted in some studies with carnitine, co-enzyme Q10 and B-vitamins. Many studies suffered from limitations, including small sample sizes, referral or publication biases, and variability in protocols for selecting children for MD workup, collecting mitochondrial biomarkers and defining MD. Overall, this evidence supports the notion that mitochondrial dysfunction is associated with ASD. Additional studies are needed to further define the role of mitochondrial dysfunction in ASD. PMID:21263444

High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome.

PubMed

De Filippis, Francesca; Pellegrini, Nicoletta; Vannini, Lucia; Jeffery, Ian B; La Storia, Antonietta; Laghi, Luca; Serrazanetti, Diana I; Di Cagno, Raffaella; Ferrocino, Ilario; Lazzi, Camilla; Turroni, Silvia; Cocolin, Luca; Brigidi, Patrizia; Neviani, Erasmo; Gobbetti, Marco; O'Toole, Paul W; Ercolini, Danilo

2016-11-01

Habitual diet plays a major role in shaping the composition of the gut microbiota, and also determines the repertoire of microbial metabolites that can influence the host. The typical Western diet corresponds to that of an omnivore; however, the Mediterranean diet (MD), common in the Western Mediterranean culture, is to date a nutritionally recommended dietary pattern that includes high-level consumption of cereals, fruit, vegetables and legumes. To investigate the potential benefits of the MD in this cross-sectional survey, we assessed the gut microbiota and metabolome in a cohort of Italian individuals in relation to their habitual diets. We retrieved daily dietary information and assessed gut microbiota and metabolome in 153 individuals habitually following omnivore, vegetarian or vegan diets. The majority of vegan and vegetarian subjects and 30% of omnivore subjects had a high adherence to the MD. We were able to stratify individuals according to both diet type and adherence to the MD on the basis of their dietary patterns and associated microbiota. We detected significant associations between consumption of vegetable-based diets and increased levels of faecal short-chain fatty acids, Prevotella and some fibre-degrading Firmicutes, whose role in human gut warrants further research. Conversely, we detected higher urinary trimethylamine oxide levels in individuals with lower adherence to the MD. High-level consumption of plant foodstuffs consistent with an MD is associated with beneficial microbiome-related metabolomic profiles in subjects ostensibly consuming a Western diet. This study was registered at clinical trials.gov as NCT02118857. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.