Science.gov

Sample records for md office 301-619-4934

  1. University of Texas MD Anderson: Phenotypic Examination of PIK3CA Allelic Series using In Vitro/In Vivo Sensor Platforms | Office of Cancer Genomics

    Cancer.gov

    The CTD2 Center at the University of Texas MD Anderson Cancer Center utilized an established and operational MCF10A normal breast epithelial cell model to assess the ability of candidate driver aberrations to promote cell grow in anchorage-independent conditions (soft agar assay) and proliferate in the absence of insulin and epidermal growth factor (EGF).

  2. 76 FR 77579 - Maryland Disaster #MD-00017

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-13

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Maryland Disaster MD-00017 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY... INFORMATION CONTACT: A. Escobar, Office of Disaster Assistance, U.S. Small Business Administration, 409...

  3. John M. Eisenberg, MD.

    PubMed

    Eisenberg, J M

    1995-08-01

    The complicated interaction between government, academic medical centers, health care payers, and burgeoning market forces has tested the leadership skills of a generation of academicians with little formal training in economics. The emergence of a new breed of physician investigator with solid business credentials has therefore proved attractive to many segments of the medical community. John M. Eisenberg received his MD from Washington University in 1972, his MBA from the Wharton School in 1976, and shortly thereafter headed the division of general internal medicine at the University of Pennsylvania. In addition to championing the role of the generalist in health care delivery, Eisenberg has also played a major part in the reformation of Medicare reimbursement. He has been a commissioner on the Congressional Physician Payment Review Commission since 1986, serving as chairman since 1993. After assuming the chairmanship of the department of medicine at Georgetown University in 1992, Eisenberg served as an advisor to the Clinton administration during its efforts towards national health care reform. Interviewed in his office in Georgetown, Eisenberg reflected on the economic forces twisting post-graduate medical education, the role of non-physician providers in future health care delivery, and the evolving relationship between specialists and generalists.

  4. 78 FR 2707 - Maryland Disaster # MD-00026

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-14

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Maryland Disaster MD-00026 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY... Deadline Date: 10/02/2013. ADDRESSES: Submit completed loan applications to: U.S. Small...

  5. MD-2 binds cholesterol.

    PubMed

    Choi, Soo-Ho; Kim, Jungsu; Gonen, Ayelet; Viriyakosol, Suganya; Miller, Yury I

    2016-02-19

    Cholesterol is a structural component of cellular membranes, which is transported from liver to peripheral cells in the form of cholesterol esters (CE), residing in the hydrophobic core of low-density lipoprotein. Oxidized CE (OxCE) is often found in plasma and in atherosclerotic lesions of subjects with cardiovascular disease. Our earlier studies have demonstrated that OxCE activates inflammatory responses in macrophages via toll-like receptor-4 (TLR4). Here we demonstrate that cholesterol binds to myeloid differentiation-2 (MD-2), a TLR4 ancillary molecule, which is a binding receptor for bacterial lipopolysaccharide (LPS) and is indispensable for LPS-induced TLR4 dimerization and signaling. Cholesterol binding to MD-2 was competed by LPS and by OxCE-modified BSA. Furthermore, soluble MD-2 in human plasma and MD-2 in mouse atherosclerotic lesions carried cholesterol, the finding supporting the biological significance of MD-2 cholesterol binding. These results help understand the molecular basis of TLR4 activation by OxCE and mechanisms of chronic inflammation in atherosclerosis.

  6. MD-2 binds cholesterol

    PubMed Central

    Choi, Soo-Ho; Kim, Jungsu; Gonen, Ayelet; Viriyakosol, Suganya; Miller, Yury I.

    2016-01-01

    Cholesterol is a structural component of cellular membranes, which is transported from liver to peripheral cells in the form of cholesterol esters (CE), residing in the hydrophobic core of low-density lipoprotein. Oxidized CE (OxCE) is often found in plasma and in atherosclerotic lesions of subjects with cardiovascular disease. Our earlier studies have demonstrated that OxCE activates inflammatory responses in macrophages via toll-like receptor-4 (TLR4). Here we demonstrate that cholesterol binds to myeloid differentiation-2 (MD-2), a TLR4 ancillary molecule, which is a binding receptor for bacterial lipopolysaccharide (LPS) and is indispensable for LPS-induced TLR4 dimerization and signaling. Cholesterol binding to MD-2 was competed by LPS and by OxCE-modified BSA. Furthermore, soluble MD-2 in human plasma and MD-2 in mouse atherosclerotic lesions carried cholesterol, the finding supporting the biological significance of MD-2 cholesterol binding. These results help understand the molecular basis of TLR4 activation by OxCE and mechanisms of chronic inflammation in atherosclerosis. PMID:26806306

  7. Muscular Dystrophy (MD)

    MedlinePlus

    ... Association National Office - 222 S. Riverside Plaza Suite 1500 Chicago IL Chicago, IL 60606 mda@mdausa.org http://www.mda. ... Association National Office - 222 S. Riverside Plaza Suite 1500 Chicago IL Chicago, IL 60606 mda@mdausa.org http:// ...

  8. Verina Morton Jones, MD.

    PubMed

    Rishworth, Susan K

    2012-01-01

    The purpose of this historical article is to demonstrate, as the biography of Verina Morton Jones, MD, is uncovered, the difficulties inherent in researching original source material on the lives of 19th- and early 20th-century African American physicians as well as the great benefits derived from doing this research. The procedures used include basic archival research and close examination of published materials about her in the past, in conjunction with oral history. Original correspondence from Dr Morton Jones to her niece and nephew is used to illustrate events in her life and the thoughts and attitudes she expressed. Some of these thoughts and attitudes reflect those current situations in which African Americans found themselves, and others are quite unique, no doubt owing to her privileged position in the African American community. The principle conclusions reached include the great benefits derived from doing this kind of research, as difficult and time-consuming as that may be, with the enhanced knowledge and appreciation of the heritage of African American physicians, and insights into American social history during this period.

  9. Visiting EPA Region 3’s Offices

    EPA Pesticide Factsheets

    Information on visiting EPA Region 3’s offices in Philadelphia, Pa., Annapolis, Md., Fort Meade, Md. and Wheeling, W. Va. including the address, building access, public transportation and driving directions.

  10. 77 FR 12476 - Drawbridge Operation Regulation; Curtis Creek, Baltimore, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-01

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Curtis Creek, Baltimore..., across Curtis Creek, mile 1.0, at Baltimore, MD. This deviation allows the bridge to operate on...

  11. 76 FR 70528 - Maryland Disaster Number MD-00018

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-14

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Maryland Disaster Number MD-00018 AGENCY: U.S. Small Business Administration. ACTION: Amendment 2... the following areas as adversely affected by the disaster. Primary Counties: Baltimore, Harford....

  12. 76 FR 70527 - Maryland Disaster Number MD-00018

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-14

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Maryland Disaster Number MD-00018 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1... hereby amended to include the following areas as adversely affected by the disaster. Primary...

  13. 75 FR 8193 - Jeri Hassman, M.D.; Denial of Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-23

    ... From the Federal Register Online via the Government Publishing Office ] Part II Department of Justice Drug Enforcement Administration Jeri Hassman, M.D.; Denial of Application; Notice #0;#0;Federal Register / Vol. 75, No. 35 / Tuesday, February 23, 2010 / Notices#0;#0; ] DEPARTMENT OF JUSTICE Drug Enforcement Administration Jeri Hassman, M.D.; Denial...

  14. Trends in Office Automation.

    ERIC Educational Resources Information Center

    School Business Affairs, 1985

    1985-01-01

    Reports the major findings of a national survey of office professionals conducted by Honeywell Incorporated. When asked how they would spend $10,000 to increase their personal productivity, the majority of workers surveyed said they would buy a computer, software, or word processor. (MD)

  15. Measurement of the Md3+/Md2+ reduction potential studied with flow electrolytic chromatography.

    PubMed

    Toyoshima, Atsushi; Li, Zijie; Asai, Masato; Sato, Nozomi; Sato, Tetsuya K; Kikuchi, Takahiro; Kaneya, Yusuke; Kitatsuji, Yoshihiro; Tsukada, Kazuaki; Nagame, Yuichiro; Schädel, Matthias; Ooe, Kazuhiro; Kasamatsu, Yoshitaka; Shinohara, Atsushi; Haba, Hiromitsu; Even, Julia

    2013-11-04

    The reduction behavior of mendelevium (Md) was studied using a flow electrolytic chromatography apparatus. By application of the appropriate potentials on the chromatography column, the more stable Md(3+) is reduced to Md(2+). The reduction potential of the Md(3+) + e(-) → Md(2+) couple was determined to be -0.16 ± 0.05 V versus a normal hydrogen electrode.

  16. Person of the year. Steven A. Schroeder, MD.

    PubMed

    Schroeder, S A

    1999-12-01

    The mission of the Robert Wood Johnson Foundation is to improve the health and health care of all Americans. An ambitious goal, but the Foundation has the financial resources to do just that. The Foundation also has another resource: President and Chief Executive Officer Steven A. Schroeder, MD, who has led the philanthropic organization since 1990. For his work with the Robert Wood Johnson Foundation, Dr. Schroeder is New Jersey Medicine's 1999 Person of the Year.

  17. 76 FR 20010 - Layfe Robert Anthony, M.D.; Denial of Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Drug Enforcement Administration Layfe Robert Anthony, M.D.; Denial of Application On December 3, 2009, the Deputy Assistant Administrator, Office of Diversion Control, Drug Enforcement Administration, issued an Order...

  18. 76 FR 20032 - Thomas E. Mitchell, M.D.; Dismissal of Proceeding

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Drug Enforcement Administration Thomas E. Mitchell, M.D.; Dismissal of Proceeding On September 11, 2009, the Deputy Assistant Administrator, Office of Diversion Control, Drug Enforcement Administration, issued an Order...

  19. 76 FR 9407 - Fraternity Federal Savings & Loan Association, Baltimore, MD; Approval of Conversion Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-17

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE TREASURY Office of Thrift Supervision Fraternity Federal Savings & Loan Association, Baltimore, MD; Approval of... approved the application of Fraternity FS&LA, Baltimore, Maryland, to convert to the stock form...

  20. 76 FR 53346 - Airworthiness Directives; The Boeing Company Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-26

    ... Model DC-9-81 (MD- 81), DC-9-82 (MD-82), DC-9-83 (MD-83), DC-9-87 (MD-87), and MD-88 Airplanes AGENCY... Jersey Avenue, SE., Washington, DC 20590. Hand Delivery: Deliver to Mail address above between 9 a.m. and...) This AD applies to The Boeing Company Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD-83),...

  1. 76 FR 41651 - Airworthiness Directives; The Boeing Company Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-15

    ... Model DC-9-81 (MD- 81), DC-9-82 (MD-82), DC-9-83 (MD-83), DC-9-87 (MD-87), and MD-88 Airplanes AGENCY... Ground Floor, Room W12-140, 1200 New Jersey Avenue, SE., Washington, DC 20590. FOR FURTHER INFORMATION...) This AD applies to The Boeing Company Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD-83),...

  2. 78 FR 14547 - Praxedes E. Alverez Santiago, M.D., Daniel Perez Brisebois, M.D., Jorge Grillasca Palou, M.D...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-06

    ... Garcia Nieves, M.D., Francis M. Vazques Roura, M.D., Angel B. Rivera Santos, M.D., Cosme D. Santos Torres... M. V zquez Roura, M.D., Angel B. Rivera Santos, M.D., Cosme D. Santos Torres, M.D., and Juan...

  3. 76 FR 5592 - Office of the Director, National Institutes of Health; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-01

    ... Director, NIH, Office of Science Policy, 6705 Rockledge Drive, Suite 750, Bethesda, MD 20892, (Telephone Conference Call) Contact Person: Lyric Jorgenson, Office of Science Policy, Office of the Director, NIH... Policy. BILLING CODE 4140-01-P...

  4. 77 FR 9228 - AP Gas & Electric (MD), LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-16

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission AP Gas & Electric (MD), LLC; Supplemental Notice That Initial Market-Based... above-referenced proceeding of AP Gas & Electric (MD), LLC's application for market-based rate...

  5. 78 FR 9044 - Adequacy Status of the Motor Vehicle Emission Budgets for Metropolitan Washington DC Area (DC-MD...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-07

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Adequacy Status of the Motor Vehicle Emission Budgets for Metropolitan Washington DC Area (DC-MD... EPA's finding, the Washington DC-MD-VA Nonattainment Area for the 1997 8-Hour Ozone National...

  6. 76 FR 1993 - Airworthiness Directives; The Boeing Company Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-12

    ... Model DC-9-81 (MD- 81), DC-9-82 (MD-82), DC-9-83 (MD-83), DC-9-87 (MD-87), and MD-88 Airplanes AGENCY... Ground Floor, Room W12-140, 1200 New Jersey Avenue, SE., Washington, DC 20590. FOR FURTHER INFORMATION.... Applicability (c) This AD applies to The Boeing Company Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83...

  7. 76 FR 13543 - Airworthiness Directives; The Boeing Company Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-14

    ... Model DC-9-81 (MD- 81), DC-9-82 (MD-82), DC-9-83 (MD-83), DC-9-87 (MD-87), and MD-88 Airplanes AGENCY... Floor, Room W12-140, 1200 New Jersey Avenue, SE., Washington, DC 20590. Hand Delivery: Deliver to Mail... stabilizer is similar in design and loading to that of the Model DC-9-81 (MD-81), DC- 9-82 (MD-82),...

  8. 76 FR 39251 - Airworthiness Directives; The Boeing Company Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-06

    ... Model DC-9-81 (MD- 81), DC-9-82 (MD-82), DC-9-83 (MD-83), DC-9-87 (MD-87), and MD-88 Airplanes AGENCY... Jersey Avenue, SE., Washington, DC 20590. FOR FURTHER INFORMATION CONTACT: Roger Durbin, Aerospace.... Applicability (c) This AD applies to all The Boeing Company Model DC-9-81 (MD- 81), DC-9-82 (MD-82), DC-9-83...

  9. The JIM interview. David Korn, MD.

    PubMed

    Korn, D

    1995-04-01

    When David Korn, MD, was named dean of the Stanford University School of Medicine on October 9, 1984, he assumed leadership of a world class research institution. Stanford was at the forefront of medicine in the areas of transplantation and oncology, and the steady influx of privately insured patients had generated a net operating surplus of $17 million in that year alone. However, in the same issue of the Stanford University Hospital newsletter which announced the selection of Korn as Dean, a small article appeared on a new prospective payment system based on diagnosis-related groups (DRGs). The article stated that the new system had begun smoothly, though some payments for cost outliers had been delayed. Other cost containment measures soon followed, most notably the implementation of managed care, and by 1990, Stanford was $14 million in the red. Buffeted by changes in medical reimbursement, competition with less costly hospitals, and a nasty squabble with Congress over indirect research costs, Stanford has been on the frontlines of a struggle now confronting many academic medical centers. After successfully consolidating the university's clinical services into a unified Stanford Health System, Korn announced that he would be stepping down as Dean on April 1. Interviewed in his office in Palo Alto, Korn reflected on the difficulties of dealing with managed care, the current financial state of the institution, and what Stanford's experience may predict for other academic medical centers.

  10. 78 FR 62640 - Office of the Director, National Institutes of Health; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-22

    ... personal privacy. Name of Committee: Office of Research Infrastructure Programs Special Emphasis Panel... Institutes of Health, 6701 Democracy Blvd., Democracy 1, Room 1082, Bethesda, MD 20892-4874,...

  11. 76 FR 52225 - Airworthiness Directives; The Boeing Company Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-22

    ... Model DC-9-81 (MD- 81), DC-9-82 (MD-82), DC-9-83 (MD-83), DC-9-87 (MD-87), and MD-88 Airplanes AGENCY... Ground Floor, Room W12-140, 1200 New Jersey Avenue, SE., Washington, DC 20590. FOR FURTHER INFORMATION... ADs (b) None. Applicability (c) This AD applies to The Boeing Company Model DC-9-81 (MD-81),...

  12. 78 FR 84 - In the Matter of: Boniface U. Ibe, 11202 Trevor Court, Mitchellville, MD 20721

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-02

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE Bureau of Industry and Security In the Matter of: Boniface U. Ibe, 11202 Trevor Court, Mitchellville, MD 20721 Order Denying Export Privileges On July 11, 2011, in the U.S. District Court, District of...

  13. 77 FR 58150 - Rene Casanova, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-19

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Drug Enforcement Administration Rene Casanova, M.D.; Decision and Order On September 29, 2011, Administrative Law Judge Timothy D. Wing issued the attached recommended decision.\\1\\ Neither party filed exceptions to the decision.\\2\\ \\1\\ All citations to...

  14. 76 FR 19434 - Roni Dreszer, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Drug Enforcement Administration Roni Dreszer, M.D.; Decision and Order On August 10, 2010, Administrative Law Judge (ALJ) John J. Mulrooney, II, issued the attached recommended decision.\\1\\ Thereafter, Respondent filed exceptions to the decision. \\1\\...

  15. 76 FR 63117 - Carlos Gonzalez, M.D., Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-11

    ... From the Federal Register Online via the Government Publishing Office ] Vol. 76 Tuesday, No. 196 October 11, 2011 Part VII Department of Justice Drug Enforcement Administration Carlos Gonzalez, M.D., Decision and Order; Notice #0;#0;Federal Register / Vol. 76 , No. 196 / Tuesday, October 11, 2011 / Notices#0;#0; ] DEPARTMENT OF JUSTICE Drug...

  16. 76 FR 21406 - Cynthia M. Cadet, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-15

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Drug Enforcement Administration Cynthia M. Cadet, M.D.; Decision and Order ACTION: Correction. On Thursday, April 7... at 76 FR 19451 under the second column. Dated: April 8, 2011. Michele M. Leonhart,...

  17. 78 FR 27431 - Jose G. Zavaleta, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-10

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Drug... Diversion Control, Drug Enforcement Administration issued an Order to Show Cause to Jose G. Zavaleta, M.D... the Drug Enforcement Administration (``DEA'' or ``Government'') should deny the application for a...

  18. 77 FR 34998 - Darryl J. Mohr, M.D.; Affirmance of Immediate Suspension Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Drug Enforcement Administration Darryl J. Mohr, M.D.; Affirmance of Immediate Suspension Order On January 20, 2011, Administrative Law Judge (ALJ) Timothy D. Wing issued the attached recommended decision (also ALJ). Thereafter, Respondent filed...

  19. 76 FR 21406 - Beau Boshers, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-15

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Drug Enforcement Administration Beau Boshers, M.D.; Decision and Order ACTION: Correction. On Thursday, April 7, 2011, the Drug Enforcement Administration published the above-titled Decision and Order, as well as...

  20. 76 FR 21406 - Roni Dreszer, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-15

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Drug Enforcement Administration Roni Dreszer, M.D.; Decision and Order ACTION: Correction. On Thursday, April 7, 2011, the Drug Enforcement Administration published the above-titled Decision and Order, as well as...

  1. 76 FR 21406 - Jacobo Dreszer, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-15

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Drug Enforcement Administration Jacobo Dreszer, M.D.; Decision and Order ACTION: Correction. On Thursday, April 7, 2011, the Drug Enforcement Administration published the above-titled Decision and Order, as well as...

  2. 76 FR 21406 - Michael J. Aruta, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-15

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Drug Enforcement Administration Michael J. Aruta, M.D.; Decision and Order ACTION: Correction. On Thursday, April 7, 2011, the Drug Enforcement Administration published the above-titled Decision and Order, as well as...

  3. 78 FR 47750 - Mireille Lalanne, M.D.; Denial of Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-06

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Drug Enforcement Administration Mireille Lalanne, M.D.; Denial of Application On August 18, 2011, Chief Administrative Law Judge (ALJ) John J. Mulrooney, II, issued the attached decision, recommending that I deny the Respondent's application for...

  4. 15. View of the Main Office (Buildings 1, 2, and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. View of the Main Office (Buildings 1, 2, and 3), U.S. Plant Introduction Station, Glenn Dale, MD, ca. 1950. Facilities and Engineering Branch. Beltsville Agricultural Research Center, Building 426. - U.S. Plant Introduction Station, 11601 Old Pond Road, Glenn Dale, Prince George's County, MD

  5. Orbital ATK – Elkton, MD MDD003067121

    EPA Pesticide Factsheets

    The EPA is announcing its environmental remediation and draft corrective action permit under the Resource Conservation and Recovery Act, as amended (RCRA), as complete with Controls for the Orbital ATK Inc. Facility (ATK), Elkton MD, (EPA ID: MDD0030671)

  6. Obituary of Philip H. Cooper, MD.

    PubMed

    Patterson, James W; Wick, Mark R; Mills, Stacey E

    2015-08-01

    Dermatopathology lost a giant in the field with the death of Philip H. Cooper, MD, on Friday, January 30, 2015. The following obituary represents a celebration of his life and his contributions to our field.

  7. 11. BEACH TOILET BUILDING, OFFICE AND FIRST AID BUILDING, PLANS, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. BEACH TOILET BUILDING, OFFICE AND FIRST AID BUILDING, PLANS, ELEVATIONS AND SECTIONS Drawing No. 103-07 - Glen Echo Park, Crystal Swimming Pool, 7300 McArthur Boulevard, Glen Echo, Montgomery County, MD

  8. VIEW IN OPPOSITE DIRECTION AS MD1351 AND MD1352. RAW MATERIAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW IN OPPOSITE DIRECTION AS MD-135-1 AND MD-135-2. RAW MATERIAL CONVEYOR AT LEFT DEPOSITS SHELL INTO MILLING MACHINE AT LOWER LEFT. ENGINE IS AT LOWER RIGHT AND RADIATOR AT LOWER CENTER. ROLLER SORTER IS AT TOP OF CONVEYOR. - F. & H. Benning Company Oyster Mill, 14430 Solomons Island Road (moved from 1014 Benning Road, Galesville, Anne Arundel County, Maryland), Solomons, Calvert County, MD

  9. 78 FR 9709 - Office of the Director, National Institutes of Health; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-11

    ... personal privacy. Name of Committee: Office of Research Infrastructure Programs Special Emphasis Panel; NIH..., 6701 Democracy Blvd., Bethesda, MD 20892. Contact Person: Mohan Viswanathan, Deputy Director, Office of...), National Institutes of Health, 6701 Democracy Blvd., Democracy 1, Room 1084, Bethesda, MD 20892-4874,...

  10. 75 FR 6162 - Airworthiness Directives; McDonnell Douglas Corporation Model DC-9-81 (MD-81), DC-9-82 (MD-82...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-08

    ... Corporation Model DC- 9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD-83), DC-9-87 (MD-87), and MD-88 Airplanes... Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD-83), DC-9-87 (MD-87), and MD-88 airplanes. This... material fatigue from normal flap operating loads. We are proposing this AD to detect and correct...

  11. 75 FR 34661 - Airworthiness Directives; McDonnell Douglas Corporation Model DC-9-81 (MD-81), DC-9-82 (MD-82...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-18

    ... Corporation Model DC- 9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD-83), DC-9-87 (MD-87), and MD-88 Airplanes...: We propose to adopt a new airworthiness directive (AD) for certain Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD-83), DC-9- 87 (MD-87), and MD-88 airplanes. This proposed AD would...

  12. 75 FR 80744 - Airworthiness Directives; McDonnell Douglas Corporation Model DC-9-81 (MD-81), DC-9-82 (MD-82...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-23

    ... Corporation Model DC- 9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD-83), DC-9-87 (MD-87), and MD-88 Airplanes...: We propose to adopt a new airworthiness directive (AD) for all Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD-83), DC-9-87 (MD- 87) and MD-88 airplanes. This proposed AD would require...

  13. Registration of cotton germplasm line md 10-5

    Technology Transfer Automated Retrieval System (TEKTRAN)

    MD 10-5 (Reg. No. ______, PI 675077) is a noncommercial breeding line of cotton (Gossypium hirsutum L.) released by the USDA-ARS at Stoneville, MS in 2015. MD 10-5 was selected in F4 progenies from a cross between MD 15 (PI 642769) and JJ 1145ne. MD 10-5 has a desirable combination between lint yi...

  14. Hazardous Waste Minimization Assessment: Fort Meade, MD

    DTIC Science & Technology

    1991-01-01

    Audit." in Wuem Mbdmi1zmim Mama (Govarmmu Inlmdu he.. Roeehdmf, MD. 19), pp 61-73 M.L R=. "Haudow Wons Mhbdms Aisu Usi4 a Two-Timed Appm." rw£nwwd...severe health problems (e.g.. gastric disorders, skin lesions. swollen limbs, cancers. tumors , eye problems. liver disorders, menstrual irregularities

  15. Modeling Nanocomposites for Molecular Dynamics (MD) Simulations

    DTIC Science & Technology

    2015-01-01

    Maximum 200 Words) The minimum energy configuration for Molecular Dynamics (MD) simulations is found for a carbon nanotube (CNT)/polymer...Carbon Nanotubes (CNTs), Molecular Dynamics Simulations 15. NUMBER OF PAGES 18 16. PRICE CODE 17. SECURITY CLASSIFICATION OF REPORT...fiber composites have shown success in improving mechanical properties. Carbon nanotube (CNT)-based nanocomposites have been studied for

  16. Howard Parnes, MD | Division of Cancer Prevention

    Cancer.gov

    Dr. Howard Parnes received a BA from Cornell University in 1977 and an MD from the University of Medicine and Dentistry of New Jersey in 1981. He trained in internal medicine at the Johns Hopkins Bayview Medical Center from 1981 to 1984 followed by a medical oncology fellowship at the University of Maryland Cancer Center (UMCC) from 1984 to 1987. |

  17. Ab Initio ONIOM-Molecular Dynamics (MD) Study on the Deamination Reaction by Cytidine Deaminase

    SciTech Connect

    Matsubara, Toshiaki; Dupuis, Michel; Aida, Misako

    2007-08-23

    We applied the ONIOM-molecular dynamics (MD) method to the hydrolytic deamination of cytidine by cytidine deaminase, which is an essential step of the activation process of the anticancer drug inside the human body. The direct MD simulations were performed for the realistic model of cytidine deaminase calculating the energy and its gradient by the ab initio ONIOM method on the fly. The ONIOM-MD calculations including the thermal motion show that the neighboring amino acid residue is an important factor of the environmental effects and significantly affects not only the geometry and energy of the substrate trapped in the pocket of the active site but also the elementary step of the catalytic reaction. We successfully simulate the second half of the catalytic cycle, which has been considered to involve the rate-determining step, and reveal that the rate-determing step is the release of the NH3 molecule. TM and MA were supported in part by grants from the Ministry of Education, Culture, Sports, Science and Technology of Japan. MD was supported by the Division of Chemical Sciences, Office of Basic Energy Sciences, and by the Office of Biological and Environmental Research of the U.S. Department of Energy DOE. Battelle operates Pacific Northwest National Laboratory for DOE.

  18. Toxic wastes discovered in Cecil County, MD

    SciTech Connect

    1994-12-31

    This report focuses on the clean-up activities following toxic waste contamination in Cecil County, MD. The potentially hazardous leakage from waste containers buried in a quarry was addressed before it was turned into a civil emergency of the magnitude of Love Canal. US Superfund is a federal government trust fund largely comprised of taxes on the chemical and petrochemical industries. Local governments share in the cost of removing the waste and other aspects of emergency management.

  19. Toxic wastes discovered in Cecil County, MD

    SciTech Connect

    Not Available

    1994-01-01

    This report focuses on the clean-up activities following toxic waste contamination in Cecil County, MD. The potentially hazardous leakage from waste containers buried in a quarry was addressed before it was turned into a civil emergency of the magnitude of Love Canal. US Superfund is a federal government trust fund largely comprised of taxes on the chemical and petrochemical industries. Local governments share in the cost of removing the waste and other aspects of emergency management.

  20. Eva Szabo, MD | Division of Cancer Prevention

    Cancer.gov

    Dr. Eva Szabo is Chief of the Lung and Upper Aerodigestive Cancer Research Group at the NCI Division of Cancer Prevention. She graduated from Yale University with a BS in Molecular Biophysics and Biochemistry, received her MD from Duke University, and completed her internal medicine residency at Bellevue-NYU Medical Center. After completing her medical oncology fellowship at the National Cancer Institute, Dr. |

  1. Graphs for Isotopes of 101-Md (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides a graphic representation of nucleon separation energies and residual interaction parameters for isotopes of the chemical element 101-Md (Mendelevium, atomic number Z = 101).

  2. Loudon Park Substation. Violetville, Baltimore City, MD. Sec. 1201, MP ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Loudon Park Substation. Violetville, Baltimore City, MD. Sec. 1201, MP 100.50. - Northeast Railroad Corridor, Amtrak route between District of Columbia/Maryland state line & Maryland/Delaware state line, Baltimore, Independent City, MD

  3. B & P Tunnel west portal. Baltimore, Baltimore City, MD. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    B & P Tunnel west portal. Baltimore, Baltimore City, MD. Sec. 1201, MP 97.43. - Northeast Railroad Corridor, Amtrak route between District of Columbia/Maryland state line & Maryland/Delaware state line, Baltimore, Independent City, MD

  4. Bacon Hill Substation. Bacon Hill, Cecil Co., MD. Sec. 1201, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Bacon Hill Substation. Bacon Hill, Cecil Co., MD. Sec. 1201, MP 48.50. - Northeast Railroad Corridor, Amtrak route between District of Columbia/Maryland state line & Maryland/Delaware state line, Baltimore, Independent City, MD

  5. 75 FR 81125 - Drawbridge Operation Regulation; Sassafras River, Georgetown, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-27

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Sassafras River, Georgetown, MD... of the Sassafras River (Route 213) Bridge, mile 10.0, in Georgetown, MD. The deviation is necessary... Sassafras River Bridge (Route 213), at mile 10.0, in Georgetown, MD has a vertical clearance in the...

  6. 77 FR 5201 - Drawbridge Operation Regulation; Bear Creek, Dundalk, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-02

    ... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Bear Creek, Dundalk, MD... across Bear Creek, mile 3.4, between Dundalk and Sparrows Point, MD. The proposed change will alter the... Avenue across Bear Creek, mile 3.4 between Dundalk and Sparrows Point, MD. This change would require...

  7. 77 FR 73967 - Drawbridge Operation Regulation; Bear Creek, Dundalk, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-12

    ... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Bear Creek, Dundalk, MD... highway bridge at Wise Avenue across Bear Creek, mile 3.4, between Dundalk and Sparrows Point, MD. The... Regulation; Bear Creek, Dundalk, MD'' in the Federal Register (77 FR 5201). The rulemaking concerned...

  8. Remains of abutments for Bridge No. 1575 at MD Rt. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Remains of abutments for Bridge No. 1575 at MD Rt. 51 in Spring Gap, Maryland, looking northeast. (Compare with HAER MD-115 photos taken 1988). - Western Maryland Railway, Cumberland Extension, Pearre to North Branch, from WM milepost 125 to 160, Pearre, Washington County, MD

  9. 75 FR 54069 - Drawbridge Operation Regulations; Curtis Creek, Baltimore, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-03

    ...-2010-0265] RIN 1625--AA09 Drawbridge Operation Regulations; Curtis Creek, Baltimore, MD AGENCY: Coast....9, across Curtis Creek at Baltimore, MD. The requested change would have allowed the bridge to... Regulation Curtis Creek, Baltimore, MD'' in the Federal Register (75 FR 30747-30750). The...

  10. Discovery of /sup 260/Md and the decay properties of /sup 258/Fm, /sup 258m,g/Md, and /sup 259/Md

    SciTech Connect

    Lougheed, R.W.; Hulet, E.K.; Dougan, R.J.; Wild, J.F.; Dupzyk, R.J.; Henderson, C.M.; Moody, K.J.; Hahn, R.L.; Suemmerer, K.; Bethune, G.

    1985-08-01

    We have discovered a new neutron-rich isotope, /sup 260/Md, from /sup 18/O and /sup 22/Ne bombardments of /sup 254/Es. We observed a spontaneous-fission (SF) activity with a 32-day half-life in electromagnetically separated mass-260 fractions from these bombardments and we have measured the mass and kinetic energy distributions of this SF activity. The mass distribution was symmetric with the principal energy peak at 234-MeV total kinetic energy (TKE), similar to previous observations for heavy Fm isotopes. Surprisingly, we also observed a smaller symmetric component with 195-MeV TKE. We interpret these two peaks in the TKE distribution as arising from two types of fission in the same nucleus, or bimodal fission. The observed fission activity may be either from the SF decay of /sup 260/Md or /sup 260/Fm which would arise from electron capture (EC) decay of /sup 260/Md. We have eliminated the possible ..beta../sup -/ decay of /sup 260/Md by measuring ..beta../sup -/-SF time correlations for the decay of /sup 260/Md and we plan to determine if /sup 260/Md decays by EC by measuring time correlations between Fm x-rays and SF events. We also measured properties for heavy Fm and Md isotopes which include: (1) more accurate cross sections for the neutron-rich Md isotopes which we use to predict the production rates of yet undiscovered nuclides; (2) improved half-live measurements for /sup 258m,g/Md and /sup 259/Md; (3) confirmation of the EC decay of /sup 258m/Md by measuring Fm x-rays preceding the SF decay of /sup 258/Fm; and (4) very substantially improved mass and TKE distributions for the SF decay of /sup 258/Fm and /sup 259/Md.

  11. Gordon Fullerton in PCA (MD-11) Simulator

    NASA Technical Reports Server (NTRS)

    1998-01-01

    NASA research pilot Gordon Fullerton 'flying' in the MD-11 simulator during the Propulsion Controlled Aircraft (PCA) project. This investigation grew out of the crash of a DC-10 airliner on July 19, 1989, following an explosion in the rear engine which caused the loss of all manual flight controls. The flight crew attempted to control the airliner using only the thrust from the two remaining engines. Although the DC-10 crashed during the landing attempt, 184 of the 296 passengers and crew aboard survived. The PCA effort at the Dryden Flight Research Center grew out of the crash, and attempted to develop a means to successfully land an aircraft using only engine thrust. After more than five years of work, on August 29, 1995, Gordon Fullerton made the first PCA touchdown aboard an MD-11 airliner (a later version of the DC-10). The concept was further refined over the years that followed this first landing. Simulators were essential ingredients of the PCA development process. The feasibility of the concept was first tested with an F-15 simulator, then the results of actual flight tests in an F-15 were incorporated back into the simulator. Additional simulations were run on the Boeing 720 airliner simulator used in the Controlled Impact Demonstration project. After the MD-11 test landings, Boeing 747 and 757 simulators tested a wide range of possible situations. Simulations even helped develop a method of landing an airliner if it lost its complete hydraulic system as well as a wing engine, by transferring fuel to shift the center of gravity toward the working engine. The most extreme procedure was undertaken in a 747 simulator. The aircraft simulated the loss of the hydraulic system at 35,000 feet and rolled upside down. Then, the PCA mode was engaged, the airliner righted itself, leveled its wings, and made an approach nearly identical to that of a normal auto landing.

  12. Orlando C. Kirton, MD, FACS, FCCM, FCCP.

    PubMed Central

    Pyrtek, Ludwig J.

    2007-01-01

    The chair is named for Ludwig J. Pyrtek, MD, an esteemed surgeon at Hartford Hospital, who was devoted to the care of his patients and was an outstanding educator within his chosen field. A unique aspect of the chair is that its income is not used to support the salary of the director but is used to enhance the education activities of the department, such as the purchasing of state-of-the-art teaching devices, support of surgical resident research activities, educational travel for residents and honoraria for nationally/internationally known clinicians/scientists to speak at grand rounds. Images p1420-a PMID:18229781

  13. Orlando C. Kirton, MD, FACS, FCCM, FCCP.

    PubMed

    Pyrtek, Ludwig J

    2007-12-01

    The chair is named for Ludwig J. Pyrtek, MD, an esteemed surgeon at Hartford Hospital, who was devoted to the care of his patients and was an outstanding educator within his chosen field. A unique aspect of the chair is that its income is not used to support the salary of the director but is used to enhance the education activities of the department, such as the purchasing of state-of-the-art teaching devices, support of surgical resident research activities, educational travel for residents and honoraria for nationally/internationally known clinicians/scientists to speak at grand rounds.

  14. ProtoMD: A prototyping toolkit for multiscale molecular dynamics

    NASA Astrophysics Data System (ADS)

    Somogyi, Endre; Mansour, Andrew Abi; Ortoleva, Peter J.

    2016-05-01

    ProtoMD is a toolkit that facilitates the development of algorithms for multiscale molecular dynamics (MD) simulations. It is designed for multiscale methods which capture the dynamic transfer of information across multiple spatial scales, such as the atomic to the mesoscopic scale, via coevolving microscopic and coarse-grained (CG) variables. ProtoMD can be also be used to calibrate parameters needed in traditional CG-MD methods. The toolkit integrates 'GROMACS wrapper' to initiate MD simulations, and 'MDAnalysis' to analyze and manipulate trajectory files. It facilitates experimentation with a spectrum of coarse-grained variables, prototyping rare events (such as chemical reactions), or simulating nanocharacterization experiments such as terahertz spectroscopy, AFM, nanopore, and time-of-flight mass spectroscopy. ProtoMD is written in python and is freely available under the GNU General Public License from github.com/CTCNano/proto_md.

  15. National Dam Inspection Program. Wye Mills Dam, (NDI-Number-MD-00029) Upper Chesapeake Bay Basin. Queen Annes County, Maryland. Phase I Inspection Report.

    DTIC Science & Technology

    1979-05-01

    AD-AOG8 799 cORPS OF ENGINEERS BALTIMORE MD BALTIMORE DISTRICT F/6 13/13 NATIONAL DAM INSPECTION PROGRAM? WYE MILLS DAM, (NOI-NJMBFR-MD---ETC(U...ARMY Baltimore District, Corps of Engineers Baltimore, Maryland 21203 Prepared by: WATER RESOURCES ADMINISTRATION Department of Natural Resources Tawes...Copies of these guidelines may be obtained from the Office of Chief of Engineers , Washington, D.C. 20314. The purpose of a Phase I Investigation is to

  16. Office automation.

    PubMed

    Arenson, R L

    1986-03-01

    By now, the term "office automation" should have more meaning for those readers who are not intimately familiar with the subject. Not all of the preceding material pertains to every department or practice, but certainly, word processing and simple telephone management are key items. The size and complexity of the organization will dictate the usefulness of electronic mail and calendar management, and the individual radiologist's personal needs and habits will determine the usefulness of the home computer. Perhaps the most important ingredient for success in the office automation arena relates to the ability to integrate information from various systems in a simple and flexible manner. Unfortunately, this is perhaps the one area that most office automation systems have ignored or handled poorly. In the personal computer world, there has been much emphasis recently on integration of packages such as spreadsheet, database management, word processing, graphics, time management, and communications. This same philosophy of integration has been applied to a few office automation systems, but these are generally vendor-specific and do not allow for a mixture of foreign subsystems. During the next few years, it is likely that a few vendors will emerge as dominant in this integrated office automation field and will stress simplicity and flexibility as major components.

  17. 78 FR 6124 - Office of the Director, National Institutes of Health; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-29

    ... personal privacy. Name of Committee: Office of Research Infrastructure Programs Special Emphasis Panel; K01... applications. Place: National Institutes of Health, One Democracy Plaza, 6701 Democracy Boulevard, Bethesda, MD... Health, 6701 Democracy Blvd., Democracy 1, Room 1070, Bethesda, MD 20892-4874, 240-271-4890,...

  18. 77 FR 50699 - Agency Information Collection Activities; Submission for Office of Management and Budget Review...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-22

    ... CONTACT: Domini Bean, Office of Information Management, Food and Drug Administration, 1350 Piccard Dr., PI50-400T, Rockville, MD 20850, 301-796-5733, domini.bean@fda.hhs.gov . SUPPLEMENTARY INFORMATION:...

  19. 78 FR 39734 - Agency Information Collection Activities; Announcement of Office of Management and Budget...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-02

    ... FURTHER INFORMATION CONTACT: Domini Bean, Office of Information Management, Food and Drug Administration, 1350 Piccard Dr., PI50-400B, Rockville, MD 20850, 301-796-5733, domini.bean@fda.hhs.gov ....

  20. 78 FR 39734 - Agency Information Collection Activities; Announcement of Office of Management and Budget...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-02

    ... CONTACT: Domini Bean, Office of Information Management, Food and Drug Administration, 1350 Piccard Dr., PI50-400B, Rockville, MD 20850, 301-796-5733, domini.bean@fda.hhs.gov . SUPPLEMENTARY INFORMATION:...

  1. 78 FR 61377 - Office of the Director, National Institutes of Health; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-03

    ... personal privacy. Name of Committee: Office of Research Infrastructure Programs Special Emphasis Panel... and evaluate grant applications. Place: National Institutes of Health, One Democracy Plaza, 6701 Democracy Boulevard, Bethesda, MD 20892. Contact Person: Sailaja Koduri, Ph.D., Scientific Review...

  2. Interview with Steven J. Levin, MD.

    PubMed

    Levin, S J

    1997-11-01

    Steven J. Levin, MD, is the only full-time physician at St. John's Health Center in New Brunswick. The Center provides primary medical services to 3,000 uninsured people and has a waiting list of almost 600 more. Levin's workdays are consumed by procuring free medications, treating patients who are poor and possibly homeless, arranging specialty consults, seeking out grants and equipment donations, and training medical students. The family physician also helped create a statefunded sexually transmitted diseases clinic, a home safety program for inner-city children, a Latino diabetes support group, and a computer database to track indigent patients in need of immunizations and other followup services. St. John's is run under an arrangement with Catholic Charities, UMDNJ-Robert Wood Johnson Medical School, and St. Peter's Medical Center.

  3. Ashley W. Oughterson, MD: Surgeon, Soldier, Leader

    PubMed Central

    Kunstman, John W.; Longo, Walter E.

    2015-01-01

    Ashley W. Oughterson, MD, (1895-1956) was a longtime faculty surgeon at Yale University. He performed some of the earliest pancreatic resections in the United States. During World War II, Colonel Oughterson was the primary “Surgical Consultant” in the South Pacific and present at nearly every major battle. His meticulously kept diary is regarded as the foremost source detailing wartime surgical care. Colonel Oughterson led the initial Army team to survey Hiroshima and Nagasaki following the nuclear attacks. Thoughout his academic career at Yale, Oughterson was a key leader in several medical and surgical societies. As scientific director of the American Cancer Society, Oughterson lectured widely and guided research priorities in oncology following World War II. Oughterson also authored numerous benchmark papers in surgical oncology that continue to be cited today. These extensive contributions are examined here and demonstrate the wide-ranging impact Oughterson exerted during a formative period of American surgery. PMID:26029018

  4. Shizuko Sei, MD | Division of Cancer Prevention

    Cancer.gov

    Dr. Shizuko Sei (formerly Shizuko Aoki) is a medical officer with over 27 years of translational and clinical research experience in the field of cancer and AIDS. After completing her pediatric oncology fellowship at NCI Center for Cancer Research (CCR), she held various positions in the CCR and Division of Cancer Treatment and Diagnosis (DCTD) before joining the DCP in July 2015. |

  5. 77 FR 24838 - Safety Zone; Magothy River, Sillery Bay, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-26

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Magothy River, Sillery Bay, MD AGENCY... waters of the Magothy River, in Sillery Bay, Maryland. This safety zone is necessary to provide for the... ``Safety Zone; Magothy River, Sillery Bay, MD'' in the Federal Register (77 FR 11423). We received...

  6. MD simulation of cluster formation during sputtering

    NASA Astrophysics Data System (ADS)

    Muramoto, T.; Okai, M.; Yamashita, Y.; Yorizane, K.; Yamamura, Y.

    2001-06-01

    The cluster ejection due to cluster impact on a solid surface is studied through molecular dynamics (MD) simulations. Simulations are performed for Cu cluster impacts on the Cu(1 1 1) surface for cluster energy 100 eV/atom, and for clusters of 6, 13, 28 and 55 atoms. Interatomic interactions are described by the AMLJ-EAM potential. The vibration energy spectrum is independent of the incident cluster size and energy. This comes from the fact that sputtered clusters become stable through the successive fragmentation of nascent large sputtered clusters. The vibration energy spectra for large sputtered clusters have a peak, whose energy corresponds to the melting temperature of Cu. The exponent of the power-law fit of the abundance distribution and the total sputtering yield for the cluster impacts are higher than that for the monatomic ion impacts with the same total energy, where the exponent δ is given by Yn∝ nδ and Yn is the yield of sputtered n-atom cluster. The exponent δ follows a unified function of the total sputtering yield, which is a monotonic increase function, and it is nearly equal to δ ˜ -3 for larger yield.

  7. Leroy D Vandam, MD: an anesthesia journey.

    PubMed

    Ortega, Rafael A

    2005-08-01

    Leroy D Vandam, MD was a remarkable man--an intricate amalgamation of an artist, scientist, and physician. He was a bastion of medical historical knowledge. Dr Vandam became a most influential anesthesiologist, some say, a giant. He was an example of someone who, with resolve, overcame adversity. His artwork is displayed in countless places, and several of his paintings form part of the Wood Library Museum Heritage Series. Dr Vandam was first a surgeon, but he abandoned surgery and pursued a career in anesthesiology under the leadership of Robert Dripps. He completed his residency training at the University of Pennsylvania and joined its staff in 1949. When he arrived at Brigham and Women's Hospital in the 1950s as director of anesthesia, he embarked on one of the most illustrious careers in American anesthesiology. Dr Vandam published more than 250 original articles, chapters, abstracts, and other reports on a wide variety of subjects including history, art, and pharmacology. His classic article on the complications of neuroaxial blocks is a seminal work in anesthesiology. This article describes how an anesthesiologist who shared an interest with Dr Vandam in the history of anesthesiology came to produce a movie based on his career, the evolution of anesthesia equipment, and the transformation of our specialty.

  8. 75 FR 12464 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-11 and MD-11F Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-16

    ... Directives; McDonnell Douglas Corporation Model MD- 11 and MD-11F Airplanes AGENCY: Federal Aviation... Management, 3855 Lakewood Boulevard, MC D800-0019, Long Beach, California 90846- 0001; telephone 206-544-5000.... The FAA amends Sec. 39.13 by adding the following new AD: McDonnell Douglas Corporation: Docket...

  9. MD-1324 and MD-1324A 5kHz Modem Overview, Issues and Status

    DTIC Science & Technology

    2011-03-01

    Contactor providing TSN support on DMR , MD-1324 1 Mar 2011 "Sustaining the Tactical Edge through reliable C4ISR UHF SATCOM Support" Distribution...UHF SATCOM Antenna and an External HPA / Up Converter (like a UHF SATCOM AN/WSC-3, ARC-210, or DMR RFS). ▼ Supports 5kHz and 25kHz DAMA and Non...Low cost light weight comms to manpac radio users and low data rate reliable comms to disadvantaged users. ▼ Simultaneously supports two

  10. An Insight into the Environmental Effects of the Pocket of the Active Site of the Enzyme. Ab initio ONIOM-Molecular Dynamics (MD) Study on Cytosine Deaminase

    SciTech Connect

    Matsubara, Toshiaki; Dupuis, Michel; Aida, Misako

    2008-02-01

    We applied the ONIOM-molecular dynamics (MD) method to cytosine deaminase to examine the environmental effects of the amino acid residues in the pocket of the active site on the substrate taking account of their thermal motion. The ab initio ONIOM-MD simulations show that the substrate uracil is strongly perturbed by the amino acid residue Ile33, which sandwiches the uracil with His62, through the steric contact due to the thermal motion. As a result, the magnitude of the thermal oscillation of the potential energy and structure of the substrate uracil significantly increases. TM and MA were partly supported by grants from the Ministry of Education, Culture, Sports, Science and Technology of Japan.MD was supported by the Division of Chemical Sciences, Office of Basic Energy Sciences, and by the Office of Biological and Environmental Research of the U.S. Department of Energy DOE. Battelle operates Pacific Northwest National Laboratory for DOE.

  11. MD-PhD training: looking back and looking forward.

    PubMed

    Bonham, Ann C

    2014-01-01

    MD-PhD programs provide rigorous, integrated training for physician-scientists, enabling them to frame scientific questions in unique ways and to apply clinical insight to fundamental science. Few would question the influential contributions of MD-PhD physician-scientists in advancing medical science. In this issue of Academic Medicine, Jeffe et al affirm high levels of excellence in educational outcomes from MD-PhD training programs at U.S. MD-granting medical schools, especially programs that receive funding from the NIH Medical Scientist Training Program (MSTP). The author of this commentary observes that, in the face of current economic pressures, comprehensive, longitudinal national outcomes data from MSTP- and non-MSTP-funded MD-PhD programs will help verify the value provided by MD-PhD physician-scientists. She proposes that MD-PhD programs should better prepare the next generation of physician-scientists for future research environments, which will provide new technologies, venues, and modalities. These research environments will be more closely integrated within health care delivery systems, extend into diverse communities and regions, and employ complex technologies. MD-PhD physician-scientists also will train and gain expertise in broadening areas of research, such as health policy, health economics, clinical epidemiology, and medical informatics. Program leaders are ideally situated to foster innovative learning environments and methodologies. By sharing their innovations, they can help ensure production of a diverse MD-PhD physician-scientist workforce, prepared to engage in myriad research opportunities to meet patient and population needs in a new environment.

  12. In Remembrance of Robert J. Arceci, M.D., Ph.D. | Office of Cancer Genomics

    Cancer.gov

    It is with great sadness and a profound sense of loss that OCG recognizes the untimely passing of Dr. Robert J. Arceci. Dr. Arceci was a co-Principal Investigator for the Acute Myeloid Leukemia (AML) project within the TARGET initiative, which aims to discover novel, more effective treatments for childhood cancers. Dr. Arceci was passionate about the use of cancer genomics to both inform therapeutic approaches in the clinic and expand the field of precision medicine.

  13. Michael S. Brown, MD and Joseph L. Goldstein, MD. 1985 Nobel laureates in medicine.

    PubMed

    Brown, M S; Goldstein, J L

    1996-02-01

    When Michael S. Brown, MD and Joseph L. Goldstein, MD first met as interns at the Massachusetts General Hospital in 1966, they could hardly have imagined that their careers would continue to be intertwined some 30 years later. It was shortly following their arrival as clinical associates at the National Institutes of Health in 1968 that the pair developed an interest in abnormalities of cholesterol metabolism. Bolstered by epidemiologic data that showed elevated cholesterol levels in many patients with myocardial infarction, Brown and Goldstein, who relocated to the University of Texas Southwestern Medical Center in 1972, began a search for receptors important in cholesterol homeostasis. These studies, performed in their early stages while juggling clinical duties at Parkland Hospital, culminated in a series of scientific achievements which merited among other honors the Hazen Award in 1982, the Lasker Award in 1985, and the Nobel Prize in Medicine in 1985. Today, as Regental Professors of the University of Texas, Brown and Goldstein head a laboratory group which continues to test the cutting edge of medical research. Although impressed with the pace of technological advances in biology, the declining role of clinically oriented physicians in biomedical research troubles the pair. Interviewed in their library in Dallas, Brown and Goldstein spoke about the complicated balance of science, medicine, and education necessary to produce another generation of successful investigators.

  14. Preparing MD-PhD students for clinical rotations: navigating the interface between PhD and MD training.

    PubMed

    Goldberg, Charles; Insel, Paul A

    2013-06-01

    Many aspects of MD-PhD training are not optimally designed to prepare students for their future roles as translational clinician-scientists. The transition between PhD research efforts and clinical rotations is one hurdle that must be overcome. MD-PhD students have deficits in clinical skills compared with those of their MD-only colleagues at the time of this transition. Reimmersion programs (RPs) targeted to MD-PhD students have the potential to help them navigate this transition.The authors draw on their experience creating and implementing an RP that incorporates multiple types of activities (clinical exam review, objective structured clinical examination, and supervised practice in patient care settings) designed to enhance the participants' skills and readiness for clinical efforts. On the basis of this experience, they note that MD-PhD students' time away from the clinical environment negatively affects their clinical skills, causing them to feel underprepared for clinical rotations. The authors argue that participation in an RP can help students feel more comfortable speaking with and examining patients and decrease their anxiety regarding clinical encounters. The authors propose that RPs can have positive outcomes for improving the transition from PhD to clinical MD training in dual-degree programs. Identifying and addressing this and other transitions need to be considered to improve the educational experience of MD-PhD students.

  15. [Photodensitometry: microdensitometry (MD): digital image processing method (DIP)].

    PubMed

    Ohama, K; Sanada, M; Nakagawa, H

    1994-09-01

    The principles of microdensitometry (MD) and digital image processing method (DIP), as well as the application of these methods to measure bone mineral density in clinical practice, were mentioned in the report. MD and DIP assess bone mineral content and bone mineral density by analyzing relative contrast of the metacarpus II on X-ray image. However, the parameters obtained by these methods have been reported to be closely related to lumber vertebral bone mineral density and whole-body bone mineral content as measured by dual energy X-ray absorptiometry (DXA). Being easy to use, MD and DIP are adequate for the screening of osteoporosis. Once any reduction in bone mineral content or bone mineral density is shown by MD or DIP, it is recommendable to measure bone mineral density of vertebrae and femoral neck by DXA.

  16. University of Texas M.D. Anderson Cancer Center

    MedlinePlus

    ... Facts & History Home Shared Governance Committee Institutional Profile Moon Shots Program Joint Commission Survey Who Was MD ... ORBIT Proteomics Translational Research Accelerator B-Cell Lymphoma Moon Shot™ The B-Cell Lymphoma Moon Shot is ...

  17. Eastman Specialties Corporation – Chestertown MD - MDD001890060

    EPA Pesticide Factsheets

    The U.S. EPA is announcing its proposed decision of Corrective Action Complete with Controls under the RCRA, for the Eastman Specialties Corporation Facility EPA ID: MDD001890060, located in Chestertown MD.

  18. Powercon Corp. settles hazardous waste violations at Severn, Md. facility

    EPA Pesticide Factsheets

    PHILADELPHIA (November 19, 2015) - Powercon Corporation has agreed to pay a $40,000 penalty to settle alleged violations of hazardous waste regulations at its manufacturing facility in Severn, Md., the U.S. Environmental Protection Agency announced today.

  19. RadNet Air Data From Baltimore, MD

    EPA Pesticide Factsheets

    This page presents radiation air monitoring and air filter analysis data for Baltimore, MD from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  20. 77 FR 47397 - Agency Information Collection Activities; Announcement of Office of Management and Budget...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-08

    ... Office of Management and Budget Approval; MedWatch: The Food and Drug Administration Medical Products... Administration Medical Products Reporting Program'' has been approved by the Office of Management and Budget (OMB... Information Management, Food and Drug Administration, 1350 Piccard Dr., PI50-400B, Rockville, MD 20850,...

  1. 75 FR 66104 - Agency Information Collection Activities; Announcement of Office of Management and Budget...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-27

    ... Office of Management and Budget Approval; Draft Guidance, Emergency Use Authorization of Medical Products... of Medical Products'' has been approved by the Office of Management and Budget (OMB) under the... Management, Food and Drug Administration, 1350 Piccard Dr., PI50-400B, Rockville, MD 20850, 301-796-3794,...

  2. 77 FR 20025 - Agency Information Collection Activities; Announcement of Office of Management and Budget...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-03

    ... Office of Management and Budget Approval; Blood Establishment Registration and Product Listing, Form FDA... and Product Listing, Form FDA 2830'' has been approved by the Office of Management and Budget (OMB... Information Management, Food and Drug Administration, 1350 Piccard Dr., PI50-400B, Rockville, MD 20850,...

  3. 75 FR 12758 - Agency Information Collection Activities; Submission for Office of Management and Budget Review...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-17

    ... Office of Management and Budget Review; Comment Request; Product Jurisdiction: Assignment of Agency... has been submitted to the Office of Management and Budget (OMB) for review and clearance under the... Management, Food and Drug Administration, 1350 Piccard Dr., PI50-400B, Rockville, MD 20850,...

  4. 76 FR 41662 - Airworthiness Directives; MD Helicopters, Inc. Model MD900 Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-15

    ... rotor lower hub assembly (lower hub) for a crack, and if you find a crack, before further flight... cracked lower hub, the existing AD requires reporting the finding to the Los Angeles Aircraft Certification Office (LAACO). That AD was prompted by two reports of cracks detected in the hub in the area...

  5. MdSOS2L1 forms a complex with MdMYB1 to control vacuolar pH by transcriptionally regulating MdVHA-B1 in apples.

    PubMed

    Sun, Cui-Hui; Zhang, Quan-Yan; Sun, Mei-Hong; Hu, Da-Gang

    2016-01-01

    Vacuolar pH is important and involves in many different physiological processes in plants. A recent paper published in Plant Physiology reveals that MdMYB1 regulates vacuolar pH by directly transcriptionally regulating proton pump genes and malate transporters genes, such as V-ATPase subunit gene MdVHA-B1. Here, we found that MdSOS2L1 in vitro did not directly interact with MdMYB1, however, in vivo formed a complex with MdMYB1 in the nucleus to regulate MdVHA-B1-mediated vacuolar acidification. This finding shed light on the role of MdSOS2L1 in transcriptionally regulating MdVHA-B1 in addition to its post-modified function in apples.

  6. MdSOS2L1 forms a complex with MdMYB1 to control vacuolar pH by transcriptionally regulating MdVHA-B1 in apples

    PubMed Central

    Sun, Cui-Hui; Zhang, Quan-Yan; Sun, Mei-Hong; Hu, Da-Gang

    2016-01-01

    ABSTRACT Vacuolar pH is important and involves in many different physiological processes in plants. A recent paper published in Plant Physiology reveals that MdMYB1 regulates vacuolar pH by directly transcriptionally regulating proton pump genes and malate transporters genes, such as V-ATPase subunit gene MdVHA-B1. Here, we found that MdSOS2L1 in vitro did not directly interact with MdMYB1, however, in vivo formed a complex with MdMYB1 in the nucleus to regulate MdVHA-B1-mediated vacuolar acidification. This finding shed light on the role of MdSOS2L1 in transcriptionally regulating MdVHA-B1 in addition to its post-modified function in apples. PMID:26910596

  7. Cummins MD & HD Accessory Hybridization CRADA -Annual Report FY15

    SciTech Connect

    Deter, Dean D.

    2015-10-01

    There are many areas of MD and HD vehicles that can be improved by new technologies and optimized control strategies. Component optimization and idle reduction need to be addressed, this is best done by a two part approach that includes selecting the best component technology, and/or architecture, and optimized controls that are vehicle focused. While this is a common focus in the light duty industry it has been gaining momentum in the MD and HD market as the market gets more competitive and the regulations become more stringent. When looking into systems optimization and idle reduction technologies, affected vehicle systems must first be considered, and if possible included in the new architecture to get the most benefit out of these new capabilities. Typically, when looking into idle reduction or component optimization for MD/HD, the vehicle s accessories become a prime candidate for electrification or hybridization. While this has already been studied on light duty vehicles (especially on hybrids and electric vehicles) it has not made any head way or market penetration in most MD and HD applications. If hybrids and electric MD and HD vehicles begin to break into the market this would be a necessary step into the ability to make those vehicles successful by allowing for independent, optimized operation separate from the engine.

  8. MD Family Medicine - Calicut experience: History is made here

    PubMed Central

    Roshni, M.

    2016-01-01

    Government Medical College, Calicut, Kerala - the first medical college in India to start Doctor of Medicine (MD) in family medicine as a postgraduate course. This was in the year 2012. Till date, this is the only medical college to have MD Family Medicine program in India. The college was allowed two MD Family Medicine seats per year by the Medical Council of India, and this is a 3 year course. The first batch of MD Family Medicine students has passed out from the Government Medical College, Calicut in July 2015. In this article, the author, who has been working as an assistant professor in the Department of Family Medicine, ever since the department started in the year 2012, shares her experiences in setting up the department, its functioning and the achievement of bringing out the first batch of successful MD Family Medicine specialists. Another laurel, of which the institution is proud of, is that they were able to incorporate family medicine teaching program in the MBBS curriculum. A brief introduction about Government Medical College, Calicut, is also given. PMID:27843820

  9. 3MdB: the Mexican Million Models database

    NASA Astrophysics Data System (ADS)

    Morisset, C.; Delgado-Inglada, G.

    2014-10-01

    The 3MdB is an original effort to construct a large multipurpose database of photoionization models. This is a more modern version of a previous attempt based on Cloudy3D and IDL tools. It is accessed by MySQL requests. The models are obtained using the well known and widely used Cloudy photoionization code (Ferland et al, 2013). The database is aimed to host grids of models with different references to identify each project and to facilitate the extraction of the desired data. We present here a description of the way the database is managed and some of the projects that use 3MdB. Anybody can ask for a grid to be run and stored in 3MdB, to increase the visibility of the grid and the potential side applications of it.

  10. CoMD Implementation Suite in Emerging Programming Models

    SciTech Connect

    Haque, Riyaz; Reeve, Sam; Juallmes, Luc; Asal, Sameer Abu; Landmehr, Aaron; Gaffer, Sanian; Teodor Bercea, Gheorghe; Rubinstein, Zach

    2014-09-23

    CoMD-Em is a software implementation suite of the CoMD [4] proxy app using different emerging programming models. It is intended to analyze the features and capabilities of novel programming models that could help ensure code and performance portability and scalability across heterogeneous platforms while improving programmer productivity. Another goal is to provide the authors and venders with some meaningful feedback regarding the capabilities and limitations of their models. The actual application is a classical molecular dynamics (MD) simulation using either the Lennard-Jones method (LJ) or the embedded atom method (EAM) for primary particle interaction. The code can be extended to support alternate interaction models. The code is expected ro run on a wide class of heterogeneous hardware configurations like shard/distributed/hybrid memory, GPU's and any other platform supported by the underlying programming model.

  11. Apple MdACS6 Regulates Ethylene Biosynthesis During Fruit Development Involving Ethylene-Responsive Factor.

    PubMed

    Li, Tong; Tan, Dongmei; Liu, Zhi; Jiang, Zhongyu; Wei, Yun; Zhang, Lichao; Li, Xinyue; Yuan, Hui; Wang, Aide

    2015-10-01

    Ethylene biosynthesis in plants involves different 1-aminocyclopropane-1-carboxylic acid synthase (ACS) genes. The regulation of each ACS gene during fruit development is unclear. Here, we characterized another apple (Malus×domestica) ACS gene, MdACS6. The transcript of MdACS6 was observed not only in fruits but also in other tissues. During fruit development, MdACS6 was initiated at a much earlier stage, whereas MdACS3a and MdACS1 began to be expressed at 35 d before harvest and immediateley after harvest, respectively. Moreover, the enzyme activity of MdACS6 was significantly lower than that of MdACS3a and MdACS1, accounting for the low ethylene biosynthesis in young fruits. Overexpression of MdACS6 (MdACS6-OE) by transient assay in apple showed enhanced ethylene production, and MdACS3a was induced in MdACS6-OE fruits but not in control fruits. In MdACS6 apple fruits silenced by the virus-induced gene silencing (VIGS) system (MdACS6-AN), neither ethylene production nor MdACS3a transcript was detectable. In order to explore the mechanism through which MdACS3a was induced in MdACS6-OE fruits, we investigated the expression of apple ethylene-responsive factor (ERF) genes. The results showed that the expression of MdERF2 was induced in MdACS6-OE fruits and inhibited in MdACS6-AN fruits. Yeast one-hybrid assay showed that MdERF2 protein could bind to the promoter of MdACS3a. Moreover, down-regulation of MdERF2 in apple flesh callus led to a decrease of MdACS3a expression, demonstrating the regulation of MdERF2 on MdACS3a. The mechanism through which MdACS6 regulates the action of MdACS3a was discussed.

  12. Single fiber electromyography (SFEMG) in mitochondrial diseases (MD).

    PubMed

    Cruz-Martínez, A; Arpa, J; Santiago, S; Pérez-Conde, C; Gutiérrez-Molina, M; Campos, Y

    2004-01-01

    Conventional EMG, nerve conduction studies and SFEMG were performed in 18 patients with various phenotypes of MD. 14 cases showed findings consistent with mild myopathy, 2 patients signs of sensory-motor axonal neuropathy and 2 cases a mixture of myopathy and axonal neuropathy. Motor unit fiber density was mild increased in 8 out of 13 tested cases. Jitter was abnormal in 10 out of 18 tested patients. Jitter abnormalities were not related to myopathic or neurogenic features in the EMG study, and may be observed in muscles without clinical weakness. The results suggest the existence of neuromuscular transmission disturbances in patients with MD.

  13. David Kasner, MD, and the Road to Pars Plana Vitrectomy

    PubMed Central

    Blodi, Christopher F.

    2016-01-01

    David Kasner, MD (1927–2001), used his extensive dissections of eye bank eyes and experiences in teaching cataract surgery to resident physicians to realize that excision of vitreous when present in the anterior chamber of eyes undergoing cataract surgery was preferable to prior intraoperative procedures. Noting that eyes tolerated his maneuvers, he then performed planned subtotal open-sky vitrectomies; first on a traumatized eye in 1961, then on two eyes of patients with amyloidosis (1966–1967). The success of these operations was noted by others, most particularly Robert Machemer, MD. Kasner’s work directly led to further surgical developments, including closed pars plana vitrectomy. PMID:27660504

  14. MdMYB9 and MdMYB11 are involved in the regulation of the JA-induced biosynthesis of anthocyanin and proanthocyanidin in apples.

    PubMed

    An, Xiu-Hong; Tian, Yi; Chen, Ke-Qin; Liu, Xiao-Juan; Liu, Dan-Dan; Xie, Xing-Bin; Cheng, Cun-Gang; Cong, Pei-Hua; Hao, Yu-Jin

    2015-04-01

    Anthocyanin and proanthocyanidin (PA) are important secondary metabolites and beneficial to human health. Their biosynthesis is induced by jasmonate (JA) treatment and regulated by MYB transcription factors (TFs). However, which and how MYB TFs regulate this process is largely unknown in apple. In this study, MdMYB9 and MdMYB11 which were induced by methyl jasmonate (MeJA) were functionally characterized. Overexpression of MdMYB9 or MdMYB11 promoted not only anthocyanin but also PA accumulation in apple calluses, and the accumulation was further enhanced by MeJA. Subsequently, yeast two-hybrid, pull-down and bimolecular fluorescence complementation assays showed that both MYB proteins interact with MdbHLH3. Moreover, Jasmonate ZIM-domain (MdJAZ) proteins interact with MdbHLH3. Furthermore, chromatin immunoprecipitation-quantitative PCR and yeast one-hybrid assays demonstrated that both MdMYB9 and MdMYB11 bind to the promoters of ANS, ANR and LAR, whereas MdbHLH3 is recruited to the promoters of MdMYB9 and MdMYB11 and regulates their transcription. In addition, transient expression assays indicated that overexpression of MdJAZ2 inhibits the recruitment of MdbHLH3 to the promoters of MdMYB9 and MdMYB11. Our findings provide new insight into the mechanism of how MeJA regulates anthocyanin and PA accumulation in apple.

  15. 76 FR 51887 - Safety Zone; Patuxent River, Patuxent River, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-19

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Patuxent River, Patuxent River, MD AGENCY... safety zone during the ``NAS Patuxent River Air Expo '11,'' which consists of aerial practices, performance demonstrations and air shows, to be held over certain waters of the Patuxent River adjacent...

  16. 76 FR 36447 - Safety Zone; Patuxent River, Patuxent River, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-22

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Patuxent River, Patuxent River, MD AGENCY... a temporary safety zone during the ``NAS Patuxent River Air Expo '11'', which consists of aerial practices, performance demonstrations and air shows, to be held over certain waters of the Patuxent...

  17. 77 FR 64709 - Airworthiness Directives; MD Helicopters, Inc.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-23

    ...), Model MD900 helicopters. The existing AD requires a visual inspection, and if necessary, an eddy current...-117, dated January 14, 2011 (SB). The SB specifies an initial 100-hour and recurring 300-hour visual... hub. (ii) If the lower hub is not replaced as a result of the visual inspection required by...

  18. 77 FR 11423 - Safety Zone; Magothy River, Sillery Bay, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-27

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Magothy River, Sillery Bay, MD AGENCY... a safety zone in certain waters of the Magothy River, in Sillery Bay, Maryland. This safety zone is... water craft held in the Magothy River, in Sillery Bay, Maryland. The proposed rule is needed to...

  19. 75 FR 30747 - Drawbridge Operation Regulation; Curtis Creek, Baltimore, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-02

    ... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Curtis Creek, Baltimore... to change the regulations that govern the operation of the Pennington Avenue Bridge across Curtis... Curtis Creek in Baltimore, MD. DATES: Comments and related material must reach the Coast Guard on...

  20. 75 FR 50707 - Drawbridge Operation Regulation; Curtis Creek, Baltimore, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-17

    ... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Curtis Creek, Baltimore... operation of the Pennington Avenue Bridge, across Curtis Creek, mile 0.9, at Baltimore, MD. This deviation... vessels bound for the Coast Guard Yard at Curtis Bay, as well as a significant amount of commercial...

  1. 75 FR 1705 - Drawbridge Operation Regulations; Curtis Creek, Baltimore, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-13

    ... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulations; Curtis Creek... operation of the I695 Bridge across Curtis Creek, mile 0.9, at Baltimore, MD. The deviation is necessary to... section of Curtis Creek and the bridge will not be able to open in the event of an emergency. Coast...

  2. Stephen Baylin, M.D., Explains Genetics and Epigenetics - TCGA

    Cancer.gov

    Stephen Baylin, M.D., at the Johns Hopkins Kimmel Cancer Center discusses the how alterations in the DNA code are deciphered in a combined effort with The Cancer Genome Atlas at the National Cancer Institute to decode the brain cancer genome.

  3. Avery D. Weisman, M.D.: An Omega Interview.

    ERIC Educational Resources Information Center

    Omega: Journal of Death and Dying, 1993

    1993-01-01

    In this interview, Avery D. Weisman, M.D., distinguished contributor to study of human encounter with death, discusses personal and professional facets of his long and productive career. Includes review of his concepts of appropriate death and middle knowledge; and findings of Project Omega, clinical research study directed by Weisman for 18…

  4. MdCOP1 ubiquitin E3 ligases interact with MdMYB1 to regulate light-induced anthocyanin biosynthesis and red fruit coloration in apple.

    PubMed

    Li, Yuan-Yuan; Mao, Ke; Zhao, Cheng; Zhao, Xian-Yan; Zhang, Hua-Lei; Shu, Huai-Rui; Hao, Yu-Jin

    2012-10-01

    MdMYB1 is a crucial regulator of light-induced anthocyanin biosynthesis and fruit coloration in apple (Malus domestica). In this study, it was found that MdMYB1 protein accumulated in the light but degraded via a ubiquitin-dependent pathway in the dark. Subsequently, the MdCOP1-1 and MdCOP1-2 genes were isolated from apple fruit peel and were functionally characterized in the Arabidopsis (Arabidopsis thaliana) cop1-4 mutant. Yeast (Saccharomyces cerevisiae) two-hybrid, bimolecular fluorescence complementation, and coimmunoprecipitation assays showed that MdMYB1 interacts with the MdCOP1 proteins. Furthermore, in vitro and in vivo experiments indicated that MdCOP1s are necessary for the ubiquitination and degradation of MdMYB1 protein in the dark and are therefore involved in the light-controlled stability of the MdMYB1 protein. Finally, a viral vector-based transformation approach demonstrated that MdCOP1s negatively regulate the peel coloration of apple fruits by modulating the degradation of the MdMYB1 protein. Our findings provide new insight into the mechanism by which light controls anthocyanin accumulation and red fruit coloration in apple and even other plant species.

  5. Spectroscopic studies beyond the N=152 neutron gap: Decay of {sub 101}{sup 255}Md and {sub 101}{sup 256}Md

    SciTech Connect

    Ahmad, I.; Chasman, R. R.; Fields, P. R.

    2000-04-01

    The isotopes {sup 255}Md and {sup 256}Md were produced by the irradiation of {sup 253}Es with 35-45 MeV {alpha} particles by ({alpha},n) and ({alpha},2n) reactions and were removed from the target by a helium jet system. {alpha}, {gamma}, and {alpha}-{gamma} coincidence spectra were measured with Si and Ge(Li) detectors. From the EC decays of {sup 255}Md and {sup 256}Md, levels in {sup 255}Fm and {sup 256}Fm were deduced. Favored {alpha} decay of {sup 255}Md was found to populate the 7/2{sup -}[514] single-particle state in {sup 251}Es, thus establishing the 7/2{sup -}[514] as the {sup 255}Md ground state. Several {gamma} rays were observed in the {sup 256}Md {alpha}-{gamma} coincidence spectrum. {sup 256}Fm is the heaviest nucleus in which excited intrinsic states have been identified. (c) 2000 The American Physical Society.

  6. Spectroscopic studies beyond N = 152 neutron gap : decay of {sup 255 ovr sub 101}Md and {sup 256 ovr sub 101}Md.

    SciTech Connect

    Ahmad, I.; Chasman, R. R.; Fields, P. R.

    2000-01-01

    The isotopes {sup 255}Md and {sup 256}Md were produced by the irradiation of {sup 253}Es with 35-45 MeV {alpha} particles by ({alpha},n) and ({alpha},2n) reactions and were removed from the target by a helium jet system. {alpha}, {gamma}, and {alpha}-{gamma} coincidence spectra were measured with Si and Ge(Li) detectors. From the EC decays of {sup 255}Md and {sup 256}Md, levels in {sup 255}Fm and {sup 256}Fm were deduced. Favored {alpha} decay of {sup 255}Md was found to populate the 7/2{sup -}[514] single-particle state in {sup 251}Es, thus establishing the 7/2{sup -}[514] as the {sup 255}Md ground state. Several {gamma} rays were observed in the {sub 256}Md {alpha}-{gamma} coincidence spectrum. {sup 256}Fm is the heaviest nucleus in which excited intrinsic states have been identified.

  7. Point-of-Care Ultrasonography for Undersea Medical Officers

    DTIC Science & Technology

    2014-11-01

    Navy Experimental Diving Unit NEDU TR 14-15 321 Bullfinch Rd NOVEMBER 2014 Panama City, FL 32407-7015 POINT-OF-CARE...MD LT, MC (SMO/UMO), USN Deputy Medical Department Head Medical Training Division Officer Navy Experimental Diving Unit (NEDU) joseph.yetto...navy.mil 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Navy Experimental Diving

  8. Postgraduate research training: the PhD and MD thesis.

    PubMed

    Higginson, I; Corner, J

    1996-04-01

    Higher research degrees, such as the PhD, MPhil and MD, have existed within universities for 80 years or more, although the differences between the MD and PhD remain confused. A higher research degree training provides individuals with greater research knowledge and skills, and benefits the specialty. Concern exists about the levels of supervision sometimes provided, failure to complete degrees, and the variable levels of research knowledge and skills attained. We propose that higher research degrees in palliative care have four functions: extending personal scholarship, generating knowledge, training for the individual and contributing to the growth of the specialty. Such an approach may include: a formalised first year with taught components such as in research MSc programmes, formal supervision and progress assessment. In palliative care, clinical and academic approaches need greater integration. Multiprofessional learning is essential. To allow individuals to undertake higher research degree programmes, fellowships or specific funding are needed.

  9. MD-80 aft cabin noise control: A case history

    NASA Technical Reports Server (NTRS)

    Lang, M. A.; Lorch, D. R.; May, D. N.; Simpson, M. A.

    1992-01-01

    The interior noise technology program to improve the noise environment in the aft cabin of the MD-80 twin jet aircraft is discussed. Two potential noise control treatments were identified: vibration absorber devices for the airframe and for the engine. A series of ground and flight tests using in-service aircraft was then conducted. These tests showed that the vibration absorbers for the airframe and engine decreased aircraft noise significantly.

  10. MD-80 aft cabin noise control: A case history

    NASA Astrophysics Data System (ADS)

    Lang, M. A.; Lorch, D. R.; May, D. N.; Simpson, M. A.

    1992-07-01

    The interior noise technology program to improve the noise environment in the aft cabin of the MD-80 twin jet aircraft is discussed. Two potential noise control treatments were identified: vibration absorber devices for the airframe and for the engine. A series of ground and flight tests using in-service aircraft was then conducted. These tests showed that the vibration absorbers for the airframe and engine decreased aircraft noise significantly.

  11. Geographic Information Office

    USGS Publications Warehouse

    ,

    2004-01-01

    The Geographic Information Office (GIO) is the principal information office for U.S. Geological Survey (USGS), focused on: Information Policy and Services, Information Technology, Science Information, Information Security, and the Federal Geographic Data Committee/Geospatial One Stop.

  12. Office of Child Care

    MedlinePlus

    ... Early Head Start-Child Care Partnerships. Review the profiles. > What is the Office of Child Care (OCC)? The Office of Child Care supports low-income working families through child care financial assistance and ...

  13. Interactive Office user's manual

    NASA Technical Reports Server (NTRS)

    Montgomery, Edward E.; Lowers, Benjamin; Nabors, Terri L.

    1990-01-01

    Given here is a user's manual for Interactive Office (IO), an executive office tool for organization and planning, written specifically for Macintosh. IO is a paperless management tool to automate a related group of individuals into one productive system.

  14. LMAL Accounting Office 1936

    NASA Technical Reports Server (NTRS)

    1936-01-01

    Accounting Office: The Langley Memorial Aeronautical Laboratory's accounting office, 1936, with photographs of the Wright brothers on the wall. Although the Lab was named after Samuel P. Langley, most of the NACA staff held the Wrights as their heroes.

  15. Office of Child Care

    MedlinePlus

    ... examples related to the health and safety training provisions of the final regulations published by the Office ... specific information and examples related to the subsidy provisions of the final regulations published by the Office ...

  16. Hybrid MC/MD Method For High Entropy Alloy

    NASA Astrophysics Data System (ADS)

    Feng, Bojun; Widom, Michael

    High entropy alloys (HEA) are materials that contain multiple components of elements consisting of a single solid solution phase which could make the entropy of mixing very high. From recent investigations, HEA's possess promising properties such as strength at high temperature, tensile strength, thermal stability and corrosion resistance. In this talk, a hybrid Molecular Dynamics (MD)/Monte Carlo (MC) simulation method is introduced to the computational analysis of HEA, treating atomic displacement by MD as well as swapping atomic species by MC. This method efficiently models the phase separation and short range order by swapping between different types of atoms, while structural deviation from the perfect lattice sites of atoms is equilibrated quickly by MD. We apply this method to HfNbTaZr HEA modeled using an embedded-atom potential. The result gives a strong phase separation of Hf-Zr and Nb-Ta pairs shown by the pair correlation function. Diffuse scattering patterns are predicted and compared to experiments. Doe Grant No. DE-SC0014506.

  17. Structure and Properties of HELICAL CARBON NANOTUBES through MD Simulations

    NASA Astrophysics Data System (ADS)

    Dahiya, Akshay; Verma, Deepti; Gupta, Shakti S.

    Helical Carbon Nanotubes (HCNTs) are coiled 3-valent carbon networks which represent pure carbon helix. Here we study the geometries of two classes: hexagonal helix containing purely polyhex networks and the second class with 5-and 7-membered rings besides hexagons. We followed a model of hexagonal, single wall HCNTs, and determined their relaxed configuration using MD simulations based on Tersoff potential. A race-track like structure is observed in the cross-section of HCNTs upon minimization. For generating class two helix, the adjacency matrix eigenvector's (AME) method is applied which utilizes 3-coordinated tiling of the plane by 5-,6-,and 7-membered ring for the construction of helical structures. The application of the AME method to torusenes is crucial for class two helix generation as it is based on an appropriate choice of bi-lobial eigenvectors triplet which can be selected on the basis of their nodal properties as verified here. After 3-D transformations the final structure was obtained with the help of MM3-potential based MD simulations on Tinker commercial code. The spring constants of HCNTs are computed through MD simulations.

  18. Pediatric office emergencies.

    PubMed

    Fuchs, Susan

    2013-10-01

    Pediatricians regularly see emergencies in the office, or children that require transfer to an emergency department, or hospitalization. An office self-assessment is the first step in determining how to prepare for an emergency. The use of mock codes and skill drills make office personnel feel less anxious about medical emergencies. Emergency information forms provide valuable, quick information about complex patients for emergency medical services and other physicians caring for patients. Furthermore, disaster planning should be part of an office preparedness plan.

  19. Office Computers: Ergonomic Considerations.

    ERIC Educational Resources Information Center

    Ganus, Susannah

    1984-01-01

    Each new report of the office automation market indicates technology is overrunning the office. The impacts of this technology are described and some ways to manage and physically "soften" the change to a computer-based office environment are suggested. (Author/MLW)

  20. Immunization against mucosal disease--bovine viral Diarrhea (MD-BVD) in calves applying lapinized vaccine against swine fever and a modified live virus of MD-BVD.

    PubMed

    Haralambiev, H; Tsvetkov, P; Nikolov, A; Gaytandgieva, R

    1975-01-01

    Calves vaccinated with the modified strain C24V react by creating neutralizing antibodies in high titres and are resistent to infection while non-immunized calves manifest the clinical symptoms of MD-BVD. Calves, vaccinated with the lapinized strain "K" of the SF virus react by creating neutralizing antibodies in low titres against the vius of MD-BVD and manifest no apparent clinical symptoms after challenge with the virulent strain MD-BVD.

  1. Molecular Basis of the Functional differences between soluble human vs. murine MD-2: Role of Val-135 in transfer of LPS from CD14 to MD-21

    PubMed Central

    Vašl, Jožica; Oblak, Alja; Peternelj, Tina T.; Klett, Javier; Martín-Santamaría, Sonsoles; Gioannini, Theresa L.; Weiss, Jerrold P.; Jerala, Roman

    2017-01-01

    Myeloid differentiation factor (MD-2) is an extracellular protein, associated with the ectodomain of Toll-like receptor 4 (TLR4), that plays a critical role in the recognition of bacterial lipopolysaccharide (LPS). Despite high overall structural and functional similarity, human (h) and murine (m) MD-2 exhibit several species-related differences. hMD-2 is capable of binding LPS in the absence of TLR4, whereas mMD-2 supports LPS responsiveness only when mMD-2 and mTLR4 are coexpressed in the same cell. Previously, charged residues at the edge of LPS binding pocket have been attributed to this difference. In this study, site-directed mutagenesis was used to explore the hydrophobic residues within MD-2 binding pocket, as the source of functional differences between hMD-2 and mMD-2. While decreased hydrophobicity of residues 61 and 63 in hMD-2 binding pocket retained the characteristics of wild type hMD-2, a relatively minor change of valine to alanine at position 135 completely abolished the binding of LPS to the hMD-2 mutant. The mutant, however, retained the LPS binding in complex with TLR4 and also cell activation, resulting in a murine-like phenotype. These results were supported by the molecular dynamics simulation. We propose that the residue at position 135 of MD-2 governs the dynamics of the binding pocket and its ability to accommodate lipid A, which is allosterically affected by bound TLR4. PMID:26826249

  2. 76 FR 81826 - Drawbridge Operation Regulation; Pocomoke River, Pocomoke City, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-29

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Pocomoke River, Pocomoke City, MD... operation of the Route 675 Bridge across Pocomoke River, mile 15.6, at Pocomoke City, MD. The deviation... across Pocomoke River, mile 15.6 at Pocomoke City, MD, has a vertical clearance in the closed position...

  3. 76 FR 5686 - Drawbridge Operation Regulation; Pocomoke River, Pocomoke City, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-02

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Pocomoke River, Pocomoke City, MD... operation of the Route 675 Bridge across Pocomoke River, mile 15.6, at Pocomoke City, MD. The deviation... at Pocomoke City MD, has a vertical clearance in the closed position of three feet above mean...

  4. 70 FR 11695 - Mario Avello, M.D.; Revocation of Registration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2005-03-09

    ... Enforcement Administration Mario Avello, M.D.; Revocation of Registration On May 17, 2004, the Deputy... Suspension of Registration to Mario Avello, M.D. (Dr. Avello) of Coral Gables, Florida. Dr. Avello was... Certificate of Registration AA0105747, issued to Mario Avello, M.D., be, and is hereby is, revoked. The...

  5. 75 FR 49991 - Beverley P. Edwards, M.D.; Revocation of Registration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-16

    ... Enforcement Administration Beverley P. Edwards, M.D.; Revocation of Registration On January 21, 2010, I, the... Suspension of Registration to Beverly P. Edwards, M.D. (Respondent), of Indianapolis, Indiana. The Show Cause... DEA Certificate of Registration, BE8619667, issued to Beverly P. Edwards, M.D., be, and it hereby...

  6. 75 FR 49978 - Nicholas J. Jerrard, M.D.; Revocation of Registration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-16

    ... Enforcement Administration Nicholas J. Jerrard, M.D.; Revocation of Registration On September 30, 2009, the...), issued an Order to Show Cause to Nicholas J. Jerrard, M.D. (Respondent), of San Diego, California. The... Respondent's State medical license. In re Nicholas Joseph Jerrard, M.D., No. 10-2006-179554, Decision at...

  7. 75 FR 8749 - Dwayne LaFrantz Wilson, M.D.; Revocation of Registration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-25

    ... Enforcement Administration Dwayne LaFrantz Wilson, M.D.; Revocation of Registration On October 22, 2008, the... Order to Show Cause to Dwayne LaFrantz Wilson, M.D. (Respondent), of Providence, Rhode Island. The Show... Certificate of Registration, BW6030857, issued to Dwayne LaFrantz Wilson, M.D., be, and it hereby is,...

  8. 75 FR 11563 - Jovencio L. Raneses, M.D.; Denial of Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-11

    ... Enforcement Administration Jovencio L. Raneses, M.D.; Denial of Application On August 28, 2009, the Deputy... Show Cause to Jovencio L. Raneses, M.D. (Respondent), of San Diego, California. The Show Cause Order... Jovencio L. Raneses, M.D., Default Decision and Order, at 1 (Med. Bd. of Cal., Jan. 27, 2009). However,...

  9. 75 FR 49955 - Hung Thien Ly, M.D.; Revocation of Registration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-16

    ... Enforcement Administration Hung Thien Ly, M.D.; Revocation of Registration On August 28, 2009, the Deputy... Show Cause to Hung Thien Ly, M.D. (Respondent), of McRae, Georgia. The Show Cause Order proposed the... Thien Ly, M.D., be, and it hereby is, revoked. I further order that any pending application of...

  10. 75 FR 49992 - Peter W.S. Grigg, M.D.; Revocation of Registration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-16

    ... Enforcement Administration Peter W.S. Grigg, M.D.; Revocation of Registration On January 2, 2009, I, the... Suspension of Registration to Peter W.S. Grigg, M.D. (Respondent), of Colorado Springs, Colorado. The Show... * * * considered in the disjunctive.'' Robert A. Leslie, M.D., 68 FR 15227, 15230 (2003). I ``may rely on any...

  11. 77 FR 29691 - Matthew J. Kachinas, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-18

    ... Doc No: 2012-12096] DEPARTMENT OF JUSTICE Drug Enforcement Administration Matthew J. Kachinas, M.D..., Drug Enforcement Administration, issued an Order to Show Cause to Matthew J. Kachinas, M.D... Matthew J. Kachinas, M.D., be, and they hereby are, revoked. I further order that any pending...

  12. 77 FR 29696 - James Edgar Lundeen, Sr., M.D.; Dismissal of Proceeding

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-18

    ... Lundeen, Sr., M.D.; Dismissal of Proceeding On December 19, 2011, the Deputy Assistant Administrator... Edgar Lundeen, Sr., M.D. (Respondent), of Uniontown, Ohio. The Order proposed the revocation of... issued to James Edgar Lundeen, Sr., M.D., be, and it hereby is, dismissed. This order is...

  13. 77 FR 35054 - Donald Brooks Reece II, M.D.; Dismissal of Proceeding

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-12

    ... Enforcement Administration Donald Brooks Reece II, M.D.; Dismissal of Proceeding On November 19, 2010, the... Order to Show Cause to Donald Brooks Reece II, M.D. (Respondent), of Morehead City, N.C. The Order... Donald Brooks Reece II, M.D., be, and it hereby is, dismissed. This Order is effective immediately....

  14. 78 FR 19009 - Gary Alfred Shearer, M.D.; Decision And Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-28

    ... Enforcement Administration Gary Alfred Shearer, M.D.; Decision And Order On February 4, 2013, Administrative... Certificate of Registration AS6213172, issued to Gary Alfred Shearer, M.D., be, and it hereby is, revoked. I further order that any pending application of Gary Alfred Shearer, M.D., to renew or modify...

  15. 77 FR 42464 - Special Local Regulations for Marine Events; Potomac River, National Harbor Access Channel, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-19

    ... River, National Harbor Access Channel, MD AGENCY: Coast Guard, DHS. ACTION: Proposed rule; withdrawal... ``Special Local Regulations for Marine Events; Potomac River, National Harbor Access Channel, MD'' in the... Channel, in Prince George's County, MD, effective from 5 a.m. until 11 a.m. on August 5, 2012....

  16. Validity of the Medical College Admission Test for Predicting MD-PhD Student Outcomes

    ERIC Educational Resources Information Center

    Bills, James L.; VanHouten, Jacob; Grundy, Michelle M.; Chalkley, Roger; Dermody, Terence S.

    2016-01-01

    The Medical College Admission Test (MCAT) is a quantitative metric used by MD and MD-PhD programs to evaluate applicants for admission. This study assessed the validity of the MCAT in predicting training performance measures and career outcomes for MD-PhD students at a single institution. The study population consisted of 153 graduates of the…

  17. 77 FR 28244 - Amendment of Class D and E Airspace; Baltimore, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-14

    ... amends Class D and E airspace at Martin State Airport, Baltimore, MD. The geographic coordinates of the... airspace, for Martin State Airport, Baltimore, MD. This update brings the geographic coordinates in concert... amends controlled airspace at Martin State Airport, Baltimore, MD. Lists of Subjects in 14 CFR Part...

  18. 76 FR 71375 - Scott D. Fedosky, M.D.; Denial of Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-17

    ... Enforcement Administration Scott D. Fedosky, M.D.; Denial of Application On March 30, 2010, the Deputy... Show Cause to Scott D. Fedosky, M.D. (Respondent), of Fayetteville, Arkansas. The Show Cause Order... Scott David Fedosky, M.D. (Ark. Med. Bd. Feb. 17, 2004). On October 8, 2003, Respondent...

  19. 78 FR 7813 - Sanjay Trivedi, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-04

    ... Enforcement Administration Sanjay Trivedi, M.D.; Decision and Order On September 25, 2012, Administrative Law... FT0896754, issued to Sanjay Trivedi, M.D., be, and it hereby is, revoked. I further order that any pending application of Sanjay Trivedi, M.D., to renew or modify his registration, be, and it hereby is, denied....

  20. 78 FR 52802 - Tin T. Win, M.D., Dismissal of Proceeding

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-26

    ... Enforcement Administration Tin T. Win, M.D., Dismissal of Proceeding On February 27, 2013, I, the... Registration to Tin T. Win, M.D. (hereinafter, Registrant), of Lake Havasu, Arizona. GX 10, at 1. Among various... Immediate Suspension of Registration issued to Tin T. Win, M.D., be, and it hereby is, dismissed. This...

  1. Crystal structure of soluble MD-1 and its interaction with lipid IVa

    SciTech Connect

    Yoon, Sung-il; Hong, Minsun; Han, Gye Won; Wilson, Ian A.

    2010-07-22

    Lipopolysaccharide (LPS) of Gram-negative bacteria is a common pathogen-associated molecular pattern (PAMP) that induces potent innate immune responses. The host immune response against LPS is triggered by myeloid differentiation factor 2 (MD-2) in association with Toll-like receptor 4 (TLR4) on the cell surface. The MD-2/TLR4-mediated LPS response is regulated by the evolutionarily related complex of MD-1 and Toll-like receptor homolog RP105. Here, we report crystallographic and biophysical data that demonstrate a previously unidentified direct interaction of MD-1 with LPS. The crystal structure of chicken MD-1 (cMD-1) at 2.0 {angstrom} resolution exhibits a {beta}-cup-like fold, similar to MD-2, that encloses a hydrophobic cavity between the two {beta}-sheets. A lipid-like moiety was observed inside the cavity, suggesting the possibility of a direct MD-1/LPS interaction. LPS was subsequently identified as an MD-1 ligand by native gel electrophoresis and gel filtration analyses. The crystal structure of cMD-1 with lipid IVa, an LPS precursor, at 2.4 {angstrom} resolution revealed that the lipid inserts into the deep hydrophobic cavity of the {beta}-cup-like structure, but with some important differences compared with MD-2. These findings suggest that soluble MD-1 alone, in addition to its complex with RP105, can regulate host LPS sensitivity.

  2. MdHIR proteins repress anthocyanin accumulation by interacting with the MdJAZ2 protein to inhibit its degradation in apples

    PubMed Central

    Chen, Ke-Qin; Zhao, Xian-Yan; An, Xiu-Hong; Tian, Yi; Liu, Dan-Dan; You, Chun-Xiang; Hao, Yu-Jin

    2017-01-01

    In higher plants, jasmonate ZIM-domain (JAZ) proteins negatively regulate the biosynthesis of anthocyanins by interacting with bHLH transcription factors. However, it is largely unknown if and how other regulators are involved in this process. In this study, the apple MdJAZ2 protein was characterized in regards to its function in the negative regulation of anthocyanin accumulation and peel coloration. MdJAZ2 was used as a bait to screen a cDNA library using the yeast two-hybrid method. The hypersensitive induced reaction (HIR) proteins, MdHIR2 and MdHIR4, were obtained from this yeast two-hybrid. The ZIM domain of MdJAZ2 and the PHB domain of the MdHIR proteins are necessary for their interactions. The interactions were further verified using an in vitro pull-down assay. Subsequently, immunoblotting assays demonstrated that MdHIR4 enhanced the stability of the MdJAZ2-GUS protein. Finally, a viral vector-based transformation method showed that MdHIR4 inhibited anthocyanin accumulation and fruit coloration in apple by modulating the expression of genes associated with anthocyanin biosynthesis. PMID:28317851

  3. 77 FR 61761 - Agency Information Collection Activities; Submission for Office of Management and Budget Review...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-11

    .... One of the most noteworthy aspects of the current healthcare environment in 2012 is the role now... practitioners will play an increasingly vital role in primary care delivery. Similarly, physician assistants... variables include: Age, gender, specialty, office based/hospital based; degree (MD or DO) and year...

  4. 7 CFR Appendix A to Part 3600 - List of State Statistical Offices

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false List of State Statistical Offices A Appendix A to Part 3600 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL AGRICULTURAL..., Suite 202, Annapolis, MD 21401 Michigan, 201 Federal Building, Lansing, MI 48904 Minnesota, 8 East...

  5. 6. Interior, rear offices: operations assistant office looking north toward ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Interior, rear offices: operations assistant office looking north toward security operations officer's office. - Ellsworth Air Force Base, Rushmore Air Force Station, Security Central Control Building, Quesada Drive, Blackhawk, Meade County, SD

  6. Repair materials and processes for the MD-11 Composite Tailcone

    NASA Astrophysics Data System (ADS)

    Yamamoto, Tetsuya; Bonnar, Gerard R.

    This paper describes field and depot level repair methods for the MD-11 Composite Tailcone. The repair materials, processing methods, and mechanical properties of the test specimens and subcomponents are discussed. According to recent tests, the dry carbon cloth and the liquid resin matrix that can be cured under 93 C have better processing and mechanical properties than the 121 C curing prepregs and film adhesives. The moisture in the parent CFRP is the main cause of creating voids in the adhesive layer during the 121 C/vacuum pressure cure cycle. The lower processing temperature (wet layup) showed better results than higher processing temperature (prepreg/adhesive layup) for composite repair.

  7. Atomic Mass and Nuclear Binding Energy for Md-337 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-337 (Mendelevium, atomic number Z = 101, mass number A = 337).

  8. Atomic Mass and Nuclear Binding Energy for Md-279 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-279 (Mendelevium, atomic number Z = 101, mass number A = 279).

  9. Atomic Mass and Nuclear Binding Energy for Md-296 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-296 (Mendelevium, atomic number Z = 101, mass number A = 296).

  10. Atomic Mass and Nuclear Binding Energy for Md-311 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-311 (Mendelevium, atomic number Z = 101, mass number A = 311).

  11. Atomic Mass and Nuclear Binding Energy for Md-338 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-338 (Mendelevium, atomic number Z = 101, mass number A = 338).

  12. Atomic Mass and Nuclear Binding Energy for Md-313 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-313 (Mendelevium, atomic number Z = 101, mass number A = 313).

  13. Atomic Mass and Nuclear Binding Energy for Md-329 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-329 (Mendelevium, atomic number Z = 101, mass number A = 329).

  14. Atomic Mass and Nuclear Binding Energy for Md-322 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-322 (Mendelevium, atomic number Z = 101, mass number A = 322).

  15. Atomic Mass and Nuclear Binding Energy for Md-286 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-286 (Mendelevium, atomic number Z = 101, mass number A = 286).

  16. Atomic Mass and Nuclear Binding Energy for Md-264 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-264 (Mendelevium, atomic number Z = 101, mass number A = 264).

  17. Atomic Mass and Nuclear Binding Energy for Md-300 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-300 (Mendelevium, atomic number Z = 101, mass number A = 300).

  18. Atomic Mass and Nuclear Binding Energy for Md-267 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-267 (Mendelevium, atomic number Z = 101, mass number A = 267).

  19. Atomic Mass and Nuclear Binding Energy for Md-284 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-284 (Mendelevium, atomic number Z = 101, mass number A = 284).

  20. Atomic Mass and Nuclear Binding Energy for Md-285 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-285 (Mendelevium, atomic number Z = 101, mass number A = 285).

  1. Atomic Mass and Nuclear Binding Energy for Md-281 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-281 (Mendelevium, atomic number Z = 101, mass number A = 281).

  2. Atomic Mass and Nuclear Binding Energy for Md-265 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-265 (Mendelevium, atomic number Z = 101, mass number A = 265).

  3. Atomic Mass and Nuclear Binding Energy for Md-298 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-298 (Mendelevium, atomic number Z = 101, mass number A = 298).

  4. Atomic Mass and Nuclear Binding Energy for Md-324 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-324 (Mendelevium, atomic number Z = 101, mass number A = 324).

  5. Atomic Mass and Nuclear Binding Energy for Md-261 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-261 (Mendelevium, atomic number Z = 101, mass number A = 261).

  6. Atomic Mass and Nuclear Binding Energy for Md-276 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-276 (Mendelevium, atomic number Z = 101, mass number A = 276).

  7. Atomic Mass and Nuclear Binding Energy for Md-259 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-259 (Mendelevium, atomic number Z = 101, mass number A = 259).

  8. Atomic Mass and Nuclear Binding Energy for Md-335 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-335 (Mendelevium, atomic number Z = 101, mass number A = 335).

  9. Atomic Mass and Nuclear Binding Energy for Md-312 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-312 (Mendelevium, atomic number Z = 101, mass number A = 312).

  10. Atomic Mass and Nuclear Binding Energy for Md-260 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-260 (Mendelevium, atomic number Z = 101, mass number A = 260).

  11. Atomic Mass and Nuclear Binding Energy for Md-321 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-321 (Mendelevium, atomic number Z = 101, mass number A = 321).

  12. Atomic Mass and Nuclear Binding Energy for Md-273 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-273 (Mendelevium, atomic number Z = 101, mass number A = 273).

  13. Atomic Mass and Nuclear Binding Energy for Md-318 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-318 (Mendelevium, atomic number Z = 101, mass number A = 318).

  14. Atomic Mass and Nuclear Binding Energy for Md-277 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-277 (Mendelevium, atomic number Z = 101, mass number A = 277).

  15. Atomic Mass and Nuclear Binding Energy for Md-266 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-266 (Mendelevium, atomic number Z = 101, mass number A = 266).

  16. Atomic Mass and Nuclear Binding Energy for Md-272 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-272 (Mendelevium, atomic number Z = 101, mass number A = 272).

  17. Atomic Mass and Nuclear Binding Energy for Md-291 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-291 (Mendelevium, atomic number Z = 101, mass number A = 291).

  18. Atomic Mass and Nuclear Binding Energy for Md-305 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-305 (Mendelevium, atomic number Z = 101, mass number A = 305).

  19. Atomic Mass and Nuclear Binding Energy for Md-269 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-269 (Mendelevium, atomic number Z = 101, mass number A = 269).

  20. Atomic Mass and Nuclear Binding Energy for Md-263 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-263 (Mendelevium, atomic number Z = 101, mass number A = 263).

  1. Atomic Mass and Nuclear Binding Energy for Md-288 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-288 (Mendelevium, atomic number Z = 101, mass number A = 288).

  2. Atomic Mass and Nuclear Binding Energy for Md-295 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-295 (Mendelevium, atomic number Z = 101, mass number A = 295).

  3. Atomic Mass and Nuclear Binding Energy for Md-262 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-262 (Mendelevium, atomic number Z = 101, mass number A = 262).

  4. Atomic Mass and Nuclear Binding Energy for Md-293 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-293 (Mendelevium, atomic number Z = 101, mass number A = 293).

  5. Atomic Mass and Nuclear Binding Energy for Md-292 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-292 (Mendelevium, atomic number Z = 101, mass number A = 292).

  6. Atomic Mass and Nuclear Binding Energy for Md-306 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-306 (Mendelevium, atomic number Z = 101, mass number A = 306).

  7. Atomic Mass and Nuclear Binding Energy for Md-271 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-271 (Mendelevium, atomic number Z = 101, mass number A = 271).

  8. Atomic Mass and Nuclear Binding Energy for Md-299 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-299 (Mendelevium, atomic number Z = 101, mass number A = 299).

  9. Atomic Mass and Nuclear Binding Energy for Md-315 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-315 (Mendelevium, atomic number Z = 101, mass number A = 315).

  10. Atomic Mass and Nuclear Binding Energy for Md-302 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-302 (Mendelevium, atomic number Z = 101, mass number A = 302).

  11. Atomic Mass and Nuclear Binding Energy for Md-274 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-274 (Mendelevium, atomic number Z = 101, mass number A = 274).

  12. Atomic Mass and Nuclear Binding Energy for Md-304 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-304 (Mendelevium, atomic number Z = 101, mass number A = 304).

  13. Atomic Mass and Nuclear Binding Energy for Md-326 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-326 (Mendelevium, atomic number Z = 101, mass number A = 326).

  14. Atomic Mass and Nuclear Binding Energy for Md-275 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-275 (Mendelevium, atomic number Z = 101, mass number A = 275).

  15. Atomic Mass and Nuclear Binding Energy for Md-310 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-310 (Mendelevium, atomic number Z = 101, mass number A = 310).

  16. Atomic Mass and Nuclear Binding Energy for Md-287 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-287 (Mendelevium, atomic number Z = 101, mass number A = 287).

  17. Atomic Mass and Nuclear Binding Energy for Md-314 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-314 (Mendelevium, atomic number Z = 101, mass number A = 314).

  18. Atomic Mass and Nuclear Binding Energy for Md-331 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-331 (Mendelevium, atomic number Z = 101, mass number A = 331).

  19. Atomic Mass and Nuclear Binding Energy for Md-336 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-336 (Mendelevium, atomic number Z = 101, mass number A = 336).

  20. Atomic Mass and Nuclear Binding Energy for Md-270 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-270 (Mendelevium, atomic number Z = 101, mass number A = 270).

  1. Atomic Mass and Nuclear Binding Energy for Md-303 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-303 (Mendelevium, atomic number Z = 101, mass number A = 303).

  2. Atomic Mass and Nuclear Binding Energy for Md-317 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-317 (Mendelevium, atomic number Z = 101, mass number A = 317).

  3. Atomic Mass and Nuclear Binding Energy for Md-268 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-268 (Mendelevium, atomic number Z = 101, mass number A = 268).

  4. Atomic Mass and Nuclear Binding Energy for Md-278 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-278 (Mendelevium, atomic number Z = 101, mass number A = 278).

  5. Atomic Mass and Nuclear Binding Energy for Md-283 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-283 (Mendelevium, atomic number Z = 101, mass number A = 283).

  6. Atomic Mass and Nuclear Binding Energy for Md-339 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-339 (Mendelevium, atomic number Z = 101, mass number A = 339).

  7. Atomic Mass and Nuclear Binding Energy for Md-307 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-307 (Mendelevium, atomic number Z = 101, mass number A = 307).

  8. Atomic Mass and Nuclear Binding Energy for Md-309 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-309 (Mendelevium, atomic number Z = 101, mass number A = 309).

  9. Atomic Mass and Nuclear Binding Energy for Md-280 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-280 (Mendelevium, atomic number Z = 101, mass number A = 280).

  10. Atomic Mass and Nuclear Binding Energy for Md-290 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-290 (Mendelevium, atomic number Z = 101, mass number A = 290).

  11. Atomic Mass and Nuclear Binding Energy for Md-325 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-325 (Mendelevium, atomic number Z = 101, mass number A = 325).

  12. Atomic Mass and Nuclear Binding Energy for Md-297 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-297 (Mendelevium, atomic number Z = 101, mass number A = 297).

  13. Atomic Mass and Nuclear Binding Energy for Md-301 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-301 (Mendelevium, atomic number Z = 101, mass number A = 301).

  14. Atomic Mass and Nuclear Binding Energy for Md-328 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-328 (Mendelevium, atomic number Z = 101, mass number A = 328).

  15. Atomic Mass and Nuclear Binding Energy for Md-308 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-308 (Mendelevium, atomic number Z = 101, mass number A = 308).

  16. Atomic Mass and Nuclear Binding Energy for Md-341 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-341 (Mendelevium, atomic number Z = 101, mass number A = 341).

  17. Atomic Mass and Nuclear Binding Energy for Md-327 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-327 (Mendelevium, atomic number Z = 101, mass number A = 327).

  18. Atomic Mass and Nuclear Binding Energy for Md-254 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-254 (Mendelevium, atomic number Z = 101, mass number A = 254).

  19. Atomic Mass and Nuclear Binding Energy for Md-323 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-323 (Mendelevium, atomic number Z = 101, mass number A = 323).

  20. Atomic Mass and Nuclear Binding Energy for Md-333 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-333 (Mendelevium, atomic number Z = 101, mass number A = 333).

  1. Atomic Mass and Nuclear Binding Energy for Md-332 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-332 (Mendelevium, atomic number Z = 101, mass number A = 332).

  2. Atomic Mass and Nuclear Binding Energy for Md-282 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-282 (Mendelevium, atomic number Z = 101, mass number A = 282).

  3. Atomic Mass and Nuclear Binding Energy for Md-294 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-294 (Mendelevium, atomic number Z = 101, mass number A = 294).

  4. Atomic Mass and Nuclear Binding Energy for Md-316 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-316 (Mendelevium, atomic number Z = 101, mass number A = 316).

  5. Atomic Mass and Nuclear Binding Energy for Md-320 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-320 (Mendelevium, atomic number Z = 101, mass number A = 320).

  6. Atomic Mass and Nuclear Binding Energy for Md-334 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-334 (Mendelevium, atomic number Z = 101, mass number A = 334).

  7. Atomic Mass and Nuclear Binding Energy for Md-289 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-289 (Mendelevium, atomic number Z = 101, mass number A = 289).

  8. Atomic Mass and Nuclear Binding Energy for Md-330 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-330 (Mendelevium, atomic number Z = 101, mass number A = 330).

  9. Atomic Mass and Nuclear Binding Energy for Md-253 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-253 (Mendelevium, atomic number Z = 101, mass number A = 253).

  10. Atomic Mass and Nuclear Binding Energy for Md-319 (Mendelevium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Md-319 (Mendelevium, atomic number Z = 101, mass number A = 319).

  11. 20 CFR 422.5 - District offices and branch offices.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false District offices and branch offices. 422.5... and Functions of the Social Security Administration § 422.5 District offices and branch offices. There are over 700 social security district offices and branch offices located in the principal cities...

  12. LifeBridge new publication: Md.MD. Listing of 1,200 physicians a major part of consumer-type magazine.

    PubMed

    Botvin, Judith D

    2004-01-01

    LifeBridge Health, Baltimore, created a directory of its physicians, which developed into a 100-page consumer magazine titled Md.MD A Directory of the Region's Finest Physicians. Written and designed in-house, the premier edition paid for itself, thanks to publishing partner, Alter Communications. The premier edition was mailed to 50,000 Baltimore area homes last September.

  13. Harvey Cushing, M.D., in his world.

    PubMed

    Hart, Curtis W

    2014-12-01

    Harvey Cushing, M.D. (1869-1939), is the acknowledged father of the discipline of neurosurgery who inspired others to join him in this new field. He was a prolific researcher in the area of human growth disturbances. And he was among the most literary of doctors having won the Pulitzer Prize for his two-volume biography of his mentor and teacher William Osler, M.D. A driven man, he both inspired and intimidated others. This essay explores Cushing's character and background along with his relationship to Osler. It seeks to understand why and how he may be considered a great figure in spite and because of his demanding and often problematic character. It further seeks to place Cushing in the context of the transition of American society and American medicine in the latter decades of the nineteenth and early decades of the twentieth century. Portions of this essay were originally delivered as part of a Grand Rounds presentation for the Department of Neurosurgery at the New York Presbyterian Hospital Weill Cornell Center.

  14. Full-Scale Crash Test of an MD-500 Helicopter

    NASA Technical Reports Server (NTRS)

    Littell, Justin

    2011-01-01

    A full-scale crash test was successfully conducted in March 2010 of an MD-500 helicopter at NASA Langley Research Center s Landing and Impact Research Facility. The reasons for conducting this test were threefold: 1 To generate data to be used with finite element computer modeling efforts, 2 To study the crashworthiness features typically associated with a small representative helicopter, and 3 To compare aircraft response to data collected from a previously conducted MD-500 crash test, which included an externally deployable energy absorbing (DEA) concept. Instrumentation on the airframe included accelerometers on various structural components of the airframe; and strain gages on keel beams, skid gear and portions of the skin. Three Anthropomorphic Test Devices and a specialized Human Surrogate Torso Model were also onboard to collect occupant loads for evaluation with common injury risk criteria. This paper presents background and results from this crash test conducted without the DEA concept. These results showed accelerations of approximately 30 to 50 g on the airframe at various locations, little energy attenuation through the airframe, and moderate to high probability of occupant injury for a variety of injury criteria.

  15. Office Safety (Part II).

    ERIC Educational Resources Information Center

    Swartz, Carl

    Toxic chemicals, noise, inadequate lighting, poor equipment design, smoking, and accidents pose serious health hazards for millions of office workers. Stress and boredom also contribute to the problems of safety. Workers should be on guard in the office for hazards, many of which are recognizable through common sense and patience. Workers must…

  16. The Automated Office.

    ERIC Educational Resources Information Center

    Naclerio, Nick

    1979-01-01

    Clerical personnel may be able to climb career ladders as a result of office automation and expanded job opportunities in the word processing area. Suggests opportunities in an automated office system and lists books and periodicals on word processing for counselors and teachers. (MF)

  17. Planning for Office Automation.

    ERIC Educational Resources Information Center

    Sherron, Gene T.

    1982-01-01

    The steps taken toward office automation by the University of Maryland are described. Office automation is defined and some types of word processing systems are described. Policies developed in the writing of a campus plan are listed, followed by a section on procedures adopted to implement the plan. (Author/MLW)

  18. The Chief Diversity Officer

    ERIC Educational Resources Information Center

    Williams, Damon; Wade-Golden, Katrina

    2007-01-01

    Numerous institutions are moving toward the chief diversity officer model of leading and managing diversity in higher education. These officers carry formal administrative titles and ranks that range from vice president for institutional diversity to associate vice chancellor for diversity and climate and dean of diversity and academic engagement.…

  19. Office of Minority Health

    MedlinePlus

    Skip Navigation Office of Minority Health A A A En Español Newsroom Contact Us Search: About OMH What We Do Resource Center Policy and Data ... Funding and Programs History Leadership Regional Staff State Minority Health Contacts Offices of Minority Health at HHS ...

  20. [Professor Frantisek Por MD and Professor Robert Klopstock MD, students at Budapest and Prague Faculties of Medicine].

    PubMed

    Mydlík, M; Derzsiová, K

    2010-11-01

    Professor Frantisek Por MD and Professor Robert Klopstock MD were contemporaries, both born in 1899, one in Zvolen, the other in Dombovar, at the time of Austro-Hungarian Monarchy. Prof. Por attended the Faculty of Medicine in Budapest from 1918 to 1920, and Prof. Klopstock studied at the same place between 1917 and 1919. From 1920 until graduation on 6th February 1926, Prof. Por continued his studies at the German Faculty of Medicine, Charles University in Prague. Prof. Klopstock had to interrupt his studies in Budapest due to pulmonary tuberculosis; he received treatment at Tatranske Matliare where he befriended Franz Kafka. Later, upon Kafka's encouragement, he changed institutions and continued his studies at the German Faculty of Medicine, Charles University in Prague, where he graduated the first great go. It is very likely that, during their studies in Budapest and Prague, both professors met repeatedly, even though their life paths later separated. Following his graduation, Prof. Por practiced as an internist in Prague, later in Slovakia, and from 1945 in Kosice. In 1961, he was awarded the title of university professor of internal medicine at the Faculty of Medicine, Pavol Jozef Safarik University in Kosice, where he practiced until his death in 1980. Prof. Klopstock continued his studies in Kiel and Berlin. After his graduation in 1933, he practiced in Berlin as a surgeon and in 1938 left for USA. In 1962, he was awarded the title of university professor of pulmonary surgery in NewYork, where he died in 1972.

  1. 78 FR 72001 - Amendment of Class D and E Airspace, and Establishment of Class E Airspace; Salisbury, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-02

    ...-Ocean City Wicomico Regional Airport, Salisbury, MD, due to the decommissioning of the Salisbury VHF... Salisbury-Ocean City Wicomico Regional Airport, Salisbury, MD. (78 FR, 52109). Interested parties were... designation is changed from Salisbury-Ocean City Wicomico Regional Airport, MD, to Salisbury, MD. The FAA...

  2. Thermal Sensitivity of MD Hematite: Implication for Magnetic Anomalies

    NASA Technical Reports Server (NTRS)

    Kletetschka, Gunther; Wasilewski, Peter J.; Taylor, Patrick T.

    1999-01-01

    Magnetic remanence of crustal rocks can reside in three common rock-forming magnetic minerals: magnetite, pyrrhotite, and hematite. Thermoremanent magnetization (TRM) of magnetite and pyrrhotite is carried mostly by single domain (SD) grains. The TRM of hematite grains, however, is carried mostly by multidomain (NM) grains. This characteristic is illustrated by TRM acquisition curves for hematite of variable grainsizes. The transition between truly NM behavior and tendency towards SD behavior his been established between hematite grainsizes of 0. 1 and 0.05 mm. Coarse grainsize of lower crustal rocks and the large sensitivity of MD hematite grains to acquire TRM indicates that hematite could be a significant contributor to long-wavelength magnetic anomalies.

  3. Emily Dickinson's ophthalmic consultation with Henry Willard Williams, MD.

    PubMed

    Blanchard, Donald L

    2012-12-01

    Emily Dickinson is one of America's premier poets of the 19th century. Henry Willard Williams, MD, was one of the very first physicians to limit his practice to ophthalmology and was the established leader in his field in Boston, Massachusetts. They met during the time of the Civil War, when Emily consulted him about her ophthalmic disorder. No records of the diagnosis survive. Photophobia, aching eyes, and a restriction in her ability to work up close were her main symptoms. Iritis, exotropia, or psychiatric problems are the most frequent diagnoses offered to explain her difficulties. Rather than attempt a definitive conclusion, this article will offer an additional possibility that Dr Williams likely considered (ie, hysterical hyperaesthesia of the retina). This was a common diagnosis at that time, although it has currently faded from use.

  4. RADIATION PRESSURE DETECTION AND DENSITY ESTIMATE FOR 2011 MD

    SciTech Connect

    Micheli, Marco; Tholen, David J.; Elliott, Garrett T. E-mail: tholen@ifa.hawaii.edu

    2014-06-10

    We present our astrometric observations of the small near-Earth object 2011 MD (H ∼ 28.0), obtained after its very close fly-by to Earth in 2011 June. Our set of observations extends the observational arc to 73 days, and, together with the published astrometry obtained around the Earth fly-by, allows a direct detection of the effect of radiation pressure on the object, with a confidence of 5σ. The detection can be used to put constraints on the density of the object, pointing to either an unexpectedly low value of ρ=(640±330)kg m{sup −3} (68% confidence interval) if we assume a typical probability distribution for the unknown albedo, or to an unusually high reflectivity of its surface. This result may have important implications both in terms of impact hazard from small objects and in light of a possible retrieval of this target.

  5. MD simulations of chain molecules in the Surface Force Apparatus.

    NASA Astrophysics Data System (ADS)

    Batista, Adriano A.; Carlson, Jean M.

    1998-03-01

    We performed MD simulations of chain molecules confined between two smooth flat crystalline plates in which we drove the top plate in two ways. In a constant shear rate in which we saw that the chains tend to align along the shear flow. We also measured the time scale associated with this alignment. In the second way we dragged the top confining plate with an elastic spring which was pulled at a constant speed. The stick-slip oscillations were overdamped. We studied the transition from stick-slip to steady-sliding and noticed that unlike the underdamped regime, this transition depends also on the elastic constant of the pulling spring. Finally we also perfomed stop-start like experiments and observed a sharp time scale for the onset of the stiction spikes in the spring force as in the experiments performed by J. Israelachvili et al.

  6. Morris Fishbein, M.D.: the "medical Mussolini" and chiropractic.

    PubMed

    Donahue, J H

    1996-06-01

    Morris Fishbein, M.D. is the most important non-chiropractor to influence the chiropractic profession. From his post as editor and secretary of the American Medical Association, his anti-chiropractic writings, speeches and political activities had a profound effect on the profession's development. Because he was not only the foremost medical politician of the time, but also perceived as a multi-faceted author on public health issues, his credibility was high across large sections of the population and in most social institutions. His tactics and stature undoubtedly helped keep the profession limited to caring for a small percentage of the population. Because of him, chiropractors devised survival strategies that continue to influence the profession even today.

  7. Leonard F. Peltier, MD, PhD, 1920-2003.

    PubMed

    Reckling, Frederick W; Lo Vecchio, Janolyn G; Reckling, JoAnn B

    2004-05-01

    Leonard F. Peltier, MD, PhD, was an orthopaedic surgeon, academician, administrator, laboratory investigator, historian, and mentor. His career spanned nearly six decades, beginning with graduate education at the University of Minnesota (UM) under the auspices of Owen H. Wangensteen, MD, PhD. In addition to obtaining a PhD in physiology in the UM Graduate School, he completed general and orthopaedic surgery residencies and attained board certification in each specialty. He served in the US Army Occupation Force Medical Corps in Germany just after World War II. In 1957, at 37 years old, he assumed the chairmanship of the orthopaedic training program at the University of Kansas. In 1971, he couldn't resist the opportunity to become one of the founding members of the "start-up" University of Arizona College of Medicine, accepting an appointment as chair of the new orthopaedic training program, where he remained until his retirement in 1990. He took clinical problems to the laboratory, and made important scientific contributions, particularly in the area of fat embolism and in using calcium sulfate (plaster of Paris) to fill bone defects. He served on governing boards of national professional organizations and presided over the American Association for the Surgery of Trauma from 1980-1981. Throughout his career, he was fascinated by, and published extensively in, the history of medicine arena. Known fondly as "the professor" to many of his residents and colleagues, he had a pragmatic, honest, upbeat, and often humorous approach to life's challenges, valuing personal integrity above other virtues. He explored various eclectic interests far beyond his professional contributions while maintaining his family as a central priority. With his exemplary productivity and interests in the surgical and laboratory sciences, history of medicine, appreciation of fine arts, and perceptive and effective interactions with family, friends, patients, and colleagues, the memory of Leonard

  8. Office-based anesthesia.

    PubMed

    Treasure, Trevor; Bennett, Jeffrey

    2007-02-01

    The practice of office-based oral and maxillofacial surgery is continuously expanding and involves the management of a diverse population in regards to the surgical procedures performed within the office and the age and medical health of the patients treated within the office. Comfort, cooperation, and hemodynamic stability are critical to satisfactorily accomplishing the surgical procedure. Various anesthetic techniques are used, including local anesthesia, anxiolysis, analgesia and sedation, and general anesthesia. The topic is vast and too extensive to be fully discussed in this article. The intent of this article is to provide a discussion of some fundamental concepts that can optimize anesthetic safety and care.

  9. Alternatively spliced myeloid differentiation protein-2 (MD-2s) protein inhibits TLR4-mediated lung inflammation

    PubMed Central

    Tumurkhuu, Gantsetseg; Dagvadorj, Jargalsaikhan; Jones, Heather D.; Chen, Shuang; Shimada, Kenichi; Crother, Timothy R.; Arditi, Moshe

    2014-01-01

    We previously identified a novel alternatively spliced isoform of human myeloid differentiation protein-2 (MD-2s) that competitively inhibits binding of MD-2 to TLR4 in vitro. Here we investigated the protective role of MD-2s in LPS-induced acute lung injury by delivering intracheally (i.t.) an adenovirus construct that expressed MD-2s (Ad-MD-2s). After adenovirus-mediated gene transfer, MD-2s was strongly expressed in lung epithelial cells and readily detected in bronchoalveolar lavage fluid (BALF). Compared to Ad-EV control mice, Ad-MD-2s delivery resulted in significantly less LPS-induced inflammation in the lungs, including less protein leakage, cell recruitment, and expression of proinflammatory cytokines and chemokines, such as IL-6, KC, and MIP-2. BALF from Ad-MD-2s mice transferred into lungs of naive mice before i.t. LPS challenge diminished pro-inflammatory cytokine levels. As house dust mite (HDM) sensitization is dependent on TLR4 and HDM Der p 2, a structural homolog of MD-2, we also investigated the effect of MD-2s on house dust mite (HDM)-induced allergic airway inflammation. Ad-MD-2s given before HDM sensitization significantly inhibited subsequent allergic airway inflammation after HDM challenge, including reductions in eosinophils, goblet cell hyperplasia, and IL-5 levels. Our study indicates that the alternatively spliced short isoform of human MD-2 could be a potential therapeutic candidate to treat human diseases induced or exacerbated by TLR4 signaling, such as Gram-negative bacterial endotoxin-induced lung injury and house dust mite-triggered allergic lung inflammation. PMID:25576596

  10. Characterization of an Autophagy-Related Gene MdATG8i from Apple

    PubMed Central

    Wang, Ping; Sun, Xun; Jia, Xin; Wang, Na; Gong, Xiaoqing; Ma, Fengwang

    2016-01-01

    Nutrient deficiencies restrict apple (Malus sp.) tree growth and productivity in Northwest China. The process of autophagy, a conserved degradation pathway in eukaryotic cells, has important roles in nutrient-recycling and helps improve plant performance during periods of nutrient-starvation. Little is known about the functioning of autophagy-related genes (ATGs) in apple. In this study, one of the ATG8 gene family members MdATG8i was isolated from Malus domestica. MdATG8i has conserved putative tubulin binding sites and ATG7 interaction domains. A 1865-bp promoter region cloned from apple genome DNA was predicated to have cis-regulatory elements responsive to light, environmental stresses, and hormones. MdATG8i transcriptions were induced in response to leaf senescence, nitrogen depletion, and oxidative stress. At cellular level, MdATG8i protein was expressed in the nucleus and cytoplasm of onion epidermal cells. Yeast two-hybrid tests showed that MdATG8i could interact with MdATG7a and MdATG7b. In Arabidopsis, its heterologous expression was associated with enhanced vegetative growth, leaf senescence, and tolerance to nitrogen- and carbon-starvation. MdATG8i-overexpressing “Orin” apple callus lines also displayed improved tolerance to nutrient-limited conditions. Our results demonstrate that MdATG8i protein could function in autophagy in a conserved way, as a positive regulator in the response to nutrient-starvation. PMID:27252732

  11. 76 FR 75448 - Establishment of Class D and E Airspace; Frederick, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-02

    ... Class D and E airspace at Frederick, MD, to accommodate new Area Navigation (RNAV) Global Positioning System (GPS) Standard Instrument Approach Procedures (SIAPs) at Frederick Municipal Airport. This...

  12. National Vaccine Program Office

    MedlinePlus

    ... Track Your Community Vaccine Safety Scientific Agenda Newsletter Sign Up Subscribe to newsletter updates for the latest information ... National Vaccine Program Office. Email Connect With NVPO Sign Up for NVPO Updates To sign up for updates ...

  13. Planning for Office Automation.

    ERIC Educational Resources Information Center

    Mick, Colin K.

    1983-01-01

    Outlines a practical approach to planning for office automation termed the "Focused Process Approach" (the "what" phase, "how" phase, "doing" phase) which is a synthesis of the problem-solving and participatory planning approaches. Thirteen references are provided. (EJS)

  14. Office proctology and sigmoidoscopy.

    PubMed

    Fraser, A

    1990-05-01

    Proctoscopy and sigmoidoscopy are readily acquired skills and should be routine office procedures for general practitioners. Correct positioning of the patient is of utmost importance to a successful examination.

  15. 76 FR 13272 - Branch Offices

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-10

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE TREASURY Office of Thrift Supervision Branch Offices AGENCY: Office of Thrift Supervision (OTS), Treasury. ACTION... 1995, 44 U.S.C. 3507. The Office of Thrift Supervision within the Department of the Treasury...

  16. Office of the Chief Financial Officer Annual Report 2009

    SciTech Connect

    Fernandez, Jeffrey

    2009-12-15

    Presented is the 2009 Chief Financial Officer's Annual Report. The data included in this report has been compiled from the Budget Office, the Controller, Procurement and Property Management and the Sponsored Projects Office.

  17. University of Texas MD Anderson Cancer Center: Characterization of PIK3R1 Neomorphic Mutations | Office of Cancer Genomics

    Cancer.gov

    The goal of this project was to functionally characterize the most frequent mutation of the PIK3R1 gene and to explore potential therapeutic approaches to target the aberration. Read the abstract Experimental Approaches Cytotoxicity Screen

  18. WCM 10-MD-03 Examination of Skip Factor Policies: For the Office of the Chief of Naval Operations

    DTIC Science & Technology

    2011-05-15

    Server (TFS) as the configuration management system. TFS keeps version and history information for the source code files, software support documentation...influence skip policy, and developed patient profiles for skip-eligible patients. The Theater Medical Data Store (TMDS) was the empirical data source for...11.4% 0.68 (0.27,1.73) Diseases of the blood and blood - forming organs 0.1% 0.3% 0.2% 10.0% 0.59 (0.18,1.94) Perinatal period conditions 0.0% 0.1% 0.1

  19. Patient Workload Profile: National Naval Medical Center (NNMC), Bethesda, MD.

    DTIC Science & Technology

    1980-06-01

    HLBLOOD Commander Technical Director ADMINISTRATIVE INFORMATION This Technical Document reports on work performed under NOSC Work Unit TA37 between 1...823- TA37 San Diego, CA 92152 1I. CONTROLLING OFFICE NAME AND ADDRESS - Naval Medical Data Services Center, I JunJ’j0 Code 04 is 1

  20. 75 FR 10172 - Drawbridge Operation Regulation; Chester River, Chestertown, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-05

    ... Government and Indian tribes, or on the distribution of power and responsibilities between the Federal... Concerning Regulations That Significantly Affect Energy Supply, Distribution, or Use. We have determined that... supply, distribution, or use of energy. The Administrator of the Office of Information and...

  1. Air Force Officer Qualifying Test (AFOQT) Form P: Test Manual

    DTIC Science & Technology

    1990-04-01

    Training Corps (AFROTC) and the Officer Training School (OTS). (The third program, which is offered at the Air Force Academy in Colorado Springs...Ine first is a pair ot words I’,md by the phrasu "is to" to express a relationship between them, followed i)v a third word, the stimulus. Ihe...cells increase from left to right and from top to bottom. A cell number may be identical to the cell number in the cell above or to the left of it or

  2. Educational Outcomes for MD-PhD Program Matriculants: A National Cohort Study

    PubMed Central

    Jeffe, Donna B.; Andriole, Dorothy A.; Wathington, Heather D.; Tai, Robert H.

    2013-01-01

    Purpose Educational outcomes for a national cohort of MD-PhD program matriculants have not been described. Method The authors used multivariate logistic regression to identify factors independently associated with overall MD-PhD program non-completion (both MD-only graduation and medical-school withdrawal/dismissal) compared with MD-PhD program graduation among the 1995–2000 national cohort of MD-PhD program enrollees at matriculation at medical schools with and without National Institutes of Health Medical Scientist Training Program (MSTP) support. Results Of 2,582 MD-PhD program enrollees in this national cohort (1,729[67.0%] men; 853[33.0%] women), 1,885 (73.0%) were MD-PhD-program graduates, 597 (23.1%) were MD-only graduates, and 100 (3.9%) withdrew/were dismissed from medical school. Enrollees at non-MSTP-funded schools compared with MSTP-funded schools (adjusted odds ratio [AOR], 1.96; 95% confidence interval [CI], 1.60–2.41) and who had lower Medical College Admission Test (MCAT) scores (<31 vs. ≥36: AOR, 1.60; 95% CI, 1.20–2.14; 31–33 vs. ≥36: AOR, 1.31; 95% CI, 1.01–1.70)were more likely to have left the MD-PhD program; enrollees who reported greater planned career involvement in research (AOR, 0.65; 95% CI, 0.51–0.84) and matriculated in more recent years (AOR,0.90; 95% CI, 0.85–0.96) were less likely to have left the MD-PhD program. Gender, race/ethnicity, and pre-medical debt were not independently associated with overall MD-PhD program non-completion. Conclusions Most MD-PhD matriculants completed the MD-PhD program, and 85.7% (597/697) of non-completers graduated from medical school. The authors’ findings regarding variables associated with MD-PhD program attrition can inform efforts to recruit and support MD-PhD program enrollees through successful completion of the dual-degree program. PMID:24280845

  3. Enhanced Allergic Inflammation of Der p 2 Affected by Polymorphisms of MD-2 Promoter

    PubMed Central

    Liao, En-Chih; Hsieh, Chia-Wei; Chang, Ching-Yun; Yu, Sheng-Jie; Sheu, Meei-Ling; Wu, Sheng-Mao

    2015-01-01

    Purpose Myeloid differentiation-2 (MD-2) has been associated with endotoxin and inflammatory disorders because it can recognize lipopolysaccharide (LPS) binding and attenuate Toll-like receptor 4 (TLR4)-mediated signaling. However, its role in allergic inflammation has yet to be clarified. We examined whether single nucleotide polymorphisms (SNPs) in MD-2 promoter can affect MD-2 expression and aimed to clarify the relationship between Der p 2 allergy and SNPs of MD-2 promoter. Methods The function of SNPs of MD-2 promoter and the effects of cytokines and immunoglobulin on the secretion and mRNA expression were investigated in 73 allergic subjects with different MD-2 gene promoter variants. Peripheral blood mononuclear cells were cultured with or without LPS in the presence of Dermatophagoides pteronyssinus group 2 allergen (Der p 2), followed by mRNA extraction and cytokine expression analysis. The culture supernatants were collected for cytokine measurement. Results Patients with the MD-2 promoter SNPs (rs1809441/rs1809442) had increased mRNA expressions of MD-2, ε heavy chain of IgE (Cε), and interleukin (IL)-8; however, only MD-2 and IL-8 were further up-regulated after Der p 2 stimulation. Patients with SNPs of MD-2 promoter tended to have high levels of IL-1β, IL-6, IL-8, IL-10, and tumor necrosis factor (TNF)-α after Der p 2 and LPS stimulation. Increased secretions of IL-6, IL-8, and IL-10 were found to be up-regulated by Der p 2 stimulation, and an increased secretion of IFN-γ and decreased secretion of IL-4 were noted after LPS stimulation. Conclusions The high levels of proinflammatory cytokines secreted by Der p 2 were predetermined by MD-2 promoter SNPs (rs1809441/rs1809442). Through cytokine secretion by Der p 2 and LPS, these SNPs may serve as an indicator of the pathological phenotype of Der p 2-induced allergic inflammation. PMID:26122509

  4. ab initio MD simulations of geomaterials with ~1000 atoms

    NASA Astrophysics Data System (ADS)

    Martin, G. B.; Kirtman, B.; Spera, F. J.

    2009-12-01

    In the last two decades, ab initio studies of materials using Density Functional Theory (DFT) have increased exponentially in popularity. DFT codes are now used routinely to simulate properties of geomaterials--mainly silicates and geochemically important metals such as Fe. These materials are ubiquitous in the Earth’s mantle and core and in terrestrial exoplanets. Because of computational limitations, most First Principles Molecular Dynamics (FPMD) calculations are done on systems of only ~100 atoms for a few picoseconds. While this approach can be useful for calculating physical quantities related to crystal structure, vibrational frequency, and other lattice-scale properties (especially in crystals), it is statistically marginal for duplicating physical properties of the liquid state like transport and structure. In MD simulations in the NEV ensemble, temperature (T), and pressure (P) fluctuations scale as N-1/2; small particle number (N) systems are therefore characterized by greater statistical state point location uncertainty than large N systems. Previous studies have used codes such as VASP where CPU time increases with N2, making calculations with N much greater than 100 impractical. SIESTA (Soler, et al. 2002) is a DFT code that enables electronic structure and MD computations on larger systems (N~103) by making some approximations, such as localized numerical orbitals, that would be useful in modeling some properties of geomaterials. Here we test the applicability of SIESTA to simulate geosilicates, both hydrous and anhydrous, in the solid and liquid state. We have used SIESTA for lattice calculations of brucite, Mg(OH)2, that compare very well to experiment and calculations using CRYSTAL, another DFT code. Good agreement between more classical DFT calculations and SIESTA is needed to justify study of geosilicates using SIESTA across a range of pressures and temperatures relevant to the Earth’s interior. Thus, it is useful to adjust parameters in

  5. [Juan Marin Rojas M.D., First Professor of History of Medicine at Universidad de Chile and his "Essay about the origin of syphilis"].

    PubMed

    Laval, Enrique

    2014-06-01

    Dr. Juan Marín Rojas, M.D., was the first Professor of History of Medicine at Universidad de Chile, navy doctor, diplomat, writer and literary critic. Member of the International Society of History of Medicine, and Correspondent Member for Chile of the "Office de Documentation de Médecine et Pharmacie Militaire", Liege, Belgium, from which his "Essay about the origin of syphilis" is transcribed with interesting historical facts and little known arguments that affirm the non-american origin of syphilis, but "aspire to leave a doubt, given not a contrary conviction".

  6. 77 FR 22523 - Safety Zone; 2012 Ocean City Air Show; Atlantic Ocean, Ocean City, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-16

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; 2012 Ocean City Air Show; Atlantic Ocean, Ocean City, MD AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking. SUMMARY: The Coast Guard proposes establishing a safety zone on the navigable waters of the Atlantic Ocean in Ocean City, MD....

  7. 78 FR 32556 - Safety Zone; 2013 Ocean City Air Show, Atlantic Ocean; Ocean City, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-31

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; 2013 Ocean City Air Show, Atlantic Ocean; Ocean City, MD AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is... City, MD to support the Ocean City Air Show. This action is intended to restrict vessel...

  8. 76 FR 31235 - Safety Zone; Ocean City Air Show, Atlantic Ocean, Ocean City, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-31

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Ocean City Air Show, Atlantic Ocean, Ocean City, MD AGENCY: Coast Guard, DHS. ACTION: Temporary Final rule. SUMMARY: The Coast Guard will establish a temporary safety zone on the Atlantic Ocean in the vicinity of Ocean City, MD to support...

  9. 76 FR 66968 - Abelardo E. Lecompte-Torres, M.D. Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-28

    ... Enforcement Administration Abelardo E. Lecompte-Torres, M.D. Decision and Order On April 29, 2010, the Deputy... Show Cause to Abelardo E. Lecompte-Torres, M.D. (Respondent), of Ponce, Puerto Rico. The Show Cause... well as 28 CFR 0.100(b) and 0.104, I order that the pending application by Abelardo E....

  10. Genome-wide histone modification profile induced by MDV in MD-resistant and -susceptible chickens

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Marek’s disease (MD) is a lymphoproliferative disease in chicken caused by oncogenic Marek’s disease virus (MDV). MD is characterized by infiltration of proliferating lymphoid cells in organs, such as peripheral nerve, skin, muscle, liver, spleen, heart, kidney, gonads and proventriculus. Epigenetic...

  11. 33 CFR 165.507 - Security Zone; Chesapeake Bay, between Sandy Point and Kent Island, MD.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., between Sandy Point and Kent Island, MD. 165.507 Section 165.507 Navigation and Navigable Waters COAST... Guard District § 165.507 Security Zone; Chesapeake Bay, between Sandy Point and Kent Island, MD. (a... to the eastern shore at Kent Island, Maryland. (c) Regulations. (1) All persons are required...

  12. 33 CFR 165.507 - Security Zone; Chesapeake Bay, between Sandy Point and Kent Island, MD.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., between Sandy Point and Kent Island, MD. 165.507 Section 165.507 Navigation and Navigable Waters COAST... Guard District § 165.507 Security Zone; Chesapeake Bay, between Sandy Point and Kent Island, MD. (a... to the eastern shore at Kent Island, Maryland. (c) Regulations. (1) All persons are required...

  13. Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran.

    PubMed

    Kim, Ho Min; Park, Beom Seok; Kim, Jung-In; Kim, Sung Eun; Lee, Judong; Oh, Se Cheol; Enkhbayar, Purevjav; Matsushima, Norio; Lee, Hayyoung; Yoo, Ook Joon; Lee, Jie-Oh

    2007-09-07

    TLR4 and MD-2 form a heterodimer that recognizes LPS (lipopolysaccharide) from Gram-negative bacteria. Eritoran is an analog of LPS that antagonizes its activity by binding to the TLR4-MD-2 complex. We determined the structure of the full-length ectodomain of the mouse TLR4 and MD-2 complex. We also produced a series of hybrids of human TLR4 and hagfish VLR and determined their structures with and without bound MD-2 and Eritoran. TLR4 is an atypical member of the LRR family and is composed of N-terminal, central, and C-terminal domains. The beta sheet of the central domain shows unusually small radii and large twist angles. MD-2 binds to the concave surface of the N-terminal and central domains. The interaction with Eritoran is mediated by a hydrophobic internal pocket in MD-2. Based on structural analysis and mutagenesis experiments on MD-2 and TLR4, we propose a model of TLR4-MD-2 dimerization induced by LPS.

  14. 75 FR 76688 - Drawbridge Operation Regulation; Isle of Wight (Sinepuxent) Bay, Ocean City, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-09

    ... (Sinepuxent) Bay, Ocean City, MD AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking. SUMMARY: The... of Wight (Sinepuxent) Bay, mile 0.5, at Ocean City, MD. This proposed rule will require any mariner... opening. The Coast Guard also proposes to change the waterway location from Isle of Wight Bay to Isle...

  15. 75 FR 21528 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ... certain Model MD-90-30 airplanes. This proposed AD would require inspecting for corrosion of the retract... system. We are proposing this AD to prevent corrosion and damage that could compromise the integrity of... Corporation MD-80 series airplanes. This condition, if not corrected, could result in corrosion and...

  16. 77 FR 7182 - Scott W. Houghton, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-10

    ... record, revoking the registrant's registration would not be appropriate. Morall v. DEA, 412 F.3d 165, 174... Registration BH8796077, issued to Scott W. Houghton, M.D., be, and it hereby is, revoked. I further order that any pending application of Scott W. Houghton, M.D., to renew or modify his registration, be, and...

  17. 76 FR 80230 - Amendment of Class D and E Airspace; Baltimore, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-23

    ... in the Federal Register of November 28, 2011, amending controlled airspace at Martin State Airport... E airspace at Martin State Airport, Baltimore, MD, and adjusting the geographic coordinates for the... airspace areas at Martin State Airport, Baltimore, MD, as published in the Federal Register of November...

  18. 33 CFR 110.71 - Jacobs Nose Cove, Elk River, Md.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Jacobs Nose Cove, Elk River, Md... ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.71 Jacobs Nose Cove, Elk River, Md. The water area of Jacobs Nose Cove, on the west side of the mouth of Elk River, Maryland, comprising the...

  19. 33 CFR 110.71 - Jacobs Nose Cove, Elk River, Md.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Jacobs Nose Cove, Elk River, Md... ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.71 Jacobs Nose Cove, Elk River, Md. The water area of Jacobs Nose Cove, on the west side of the mouth of Elk River, Maryland, comprising the...

  20. 33 CFR 110.71 - Jacobs Nose Cove, Elk River, Md.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Jacobs Nose Cove, Elk River, Md... ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.71 Jacobs Nose Cove, Elk River, Md. The water area of Jacobs Nose Cove, on the west side of the mouth of Elk River, Maryland, comprising the...

  1. 33 CFR 110.71 - Jacobs Nose Cove, Elk River, Md.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Jacobs Nose Cove, Elk River, Md... ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.71 Jacobs Nose Cove, Elk River, Md. The water area of Jacobs Nose Cove, on the west side of the mouth of Elk River, Maryland, comprising the...

  2. 33 CFR 110.71 - Jacobs Nose Cove, Elk River, Md.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Jacobs Nose Cove, Elk River, Md... ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.71 Jacobs Nose Cove, Elk River, Md. The water area of Jacobs Nose Cove, on the west side of the mouth of Elk River, Maryland, comprising the...

  3. 75 FR 30860 - Shepard Ginandes, M.D.; Revocation of Registration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-02

    ... Enforcement Administration Shepard Ginandes, M.D.; Revocation of Registration On September 28, 2009, I, the... Suspension of Registration to Shepard Ginandes, M.D. (Respondent), of Honolulu, Hawaii. The Show Cause Order.... (citing 21 CFR 1301.43(d) & (e)). On September 30, 2009, the Order was served on Respondent. On November...

  4. 77 FR 3796 - Mladen Antolic, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-25

    ... Enforcement Administration Mladen Antolic, M.D.; Decision and Order On August 8, 2011, the Deputy Assistant... Mladen Antolic, M.D. (Registrant), of Orlando, Florida. The Show Cause Order proposed the revocation of... Order based on relevant evidence contained in the record submitted by the Government. 21 CFR...

  5. 77 FR 67669 - Wayne D. Longmore, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-13

    ... Enforcement Administration Wayne D. Longmore, M.D.; Decision and Order On September 6, 2012, Administrative... 28 CFR 0.100(b), I order that DEA Certificate of Registration Number BL9651250, issued to Wayne D. Longmore, M.D., be, and it hereby is, revoked. I further order that any pending application of Wayne...

  6. The MD simulation of thermal properties of plutonium dioxide

    NASA Astrophysics Data System (ADS)

    Mingjie, Wan; Li, Zhang; Jiguang, Du; Duohui, Huang; Lili, Wang; Gang, Jiang

    2012-12-01

    The thermodynamic properties of PuO2 have been investigated between 300 and 3000 K by molecular dynamics (MD) simulation with empirical interaction potential. The properties include melting point, lattice parameter variation, enthalpy and heat capacity. The melting point of two-phase simulation (TPS) is in agreement with the experimental value, and it gives a much lower value than one-phase simulation (OPS). The lattice parameter and heat capacity at high temperatures are expressed as a(T)=5.38178+4.38×10-5T+6.5525×10-9T+0.9362×10-12T and CP(KJṡmol-1ṡK-1)=18648.8e/(T(-1)2)+9.337×10-6T, respectively. True linear thermal expansion coefficient (TLTEC) α is about 8.89×10-6 K-1 at 300 K. Our simulation results are in good agreement with experimental and other theoretical data.

  7. [A tribute to Richard V. Lee, M.D].

    PubMed

    Reyes B, Humberto

    2013-10-01

    Richard V Lee, MD, MACP, FRGS, Professor of Medicine and Pediatrics and Obstetrics, Adjunct Professor of Anthropology and Social and Preventive Medicine. Director, Division of Maternal & Adolescent Medicine, and Director, Division of Geographic Medicine, Department of Medicine, State University of New York at Buffalo, USA, passed away on May 7,2013. His academic degrees and university positions are a vivid testimony of his wide professional interests and capabilities. As a humanist and ecologist, he became involved in a broad range of medical and research activities in the Brazilian Amazon, the Chilean Southern Andes, the African deserts and highlands, India, the Himalayas, and China. His extensive bibliography on ecology, the health status of geographically isolated populations and the role of physicians on cultural and macro environmental factors, has been summarized in his posthumous book "Out of Bounds. Medicine and The Hundred Acre Wood", recently published by the Royal Society of Medicine, London. The Sociedad Médica de Santiago-Chilean Society of Internal Medicine and its journal Revista Médica de Chile are indebted to his enthusiastic contributions and advice.

  8. Using MD Simulations To Calculate How Solvents Modulate Solubility.

    PubMed

    Liu, Shuai; Cao, Shannon; Hoang, Kevin; Young, Kayla L; Paluch, Andrew S; Mobley, David L

    2016-04-12

    Here, our interest is in predicting solubility in general, and we focus particularly on predicting how the solubility of particular solutes is modulated by the solvent environment. Solubility in general is extremely important, both for theoretical reasons - it provides an important probe of the balance between solute-solute and solute-solvent interactions - and for more practical reasons, such as how to control the solubility of a given solute via modulation of its environment, as in process chemistry and separations. Here, we study how the change of solvent affects the solubility of a given compound. That is, we calculate relative solubilities. We use MD simulations to calculate relative solubility and compare our calculated values with experiment as well as with results from several other methods, SMD and UNIFAC, the latter of which is commonly used in chemical engineering design. We find that straightforward solubility calculations based on molecular simulations using a general small-molecule force field outperform SMD and UNIFAC both in terms of accuracy and coverage of the relevant chemical space.

  9. Center of excellence for mobile sensor data-to-knowledge (MD2K)

    PubMed Central

    Kumar, Santosh; Abowd, Gregory D; Abraham, William T; al’Absi, Mustafa; Gayle Beck, J; Chau, Duen Horng; Condie, Tyson; Conroy, David E; Ertin, Emre; Estrin, Deborah; Ganesan, Deepak; Lam, Cho; Marlin, Benjamin; Marsh, Clay B; Murphy, Susan A; Nahum-Shani, Inbal; Patrick, Kevin; Rehg, James M; Sharmin, Moushumi; Shetty, Vivek; Sim, Ida; Spring, Bonnie; Srivastava, Mani; Wetter, David W

    2015-01-01

    Mobile sensor data-to-knowledge (MD2K) was chosen as one of 11 Big Data Centers of Excellence by the National Institutes of Health, as part of its Big Data-to-Knowledge initiative. MD2K is developing innovative tools to streamline the collection, integration, management, visualization, analysis, and interpretation of health data generated by mobile and wearable sensors. The goal of the big data solutions being developed by MD2K is to reliably quantify physical, biological, behavioral, social, and environmental factors that contribute to health and disease risk. The research conducted by MD2K is targeted at improving health through early detection of adverse health events and by facilitating prevention. MD2K will make its tools, software, and training materials widely available and will also organize workshops and seminars to encourage their use by researchers and clinicians. PMID:26555017

  10. Center of excellence for mobile sensor data-to-knowledge (MD2K).

    PubMed

    Kumar, Santosh; Abowd, Gregory D; Abraham, William T; al'Absi, Mustafa; Beck, J Gayle; Chau, Duen Horng; Condie, Tyson; Conroy, David E; Ertin, Emre; Estrin, Deborah; Ganesan, Deepak; Lam, Cho; Marlin, Benjamin; Marsh, Clay B; Murphy, Susan A; Nahum-Shani, Inbal; Patrick, Kevin; Rehg, James M; Sharmin, Moushumi; Shetty, Vivek; Sim, Ida; Spring, Bonnie; Srivastava, Mani; Wetter, David W

    2015-11-01

    Mobile sensor data-to-knowledge (MD2K) was chosen as one of 11 Big Data Centers of Excellence by the National Institutes of Health, as part of its Big Data-to-Knowledge initiative. MD2K is developing innovative tools to streamline the collection, integration, management, visualization, analysis, and interpretation of health data generated by mobile and wearable sensors. The goal of the big data solutions being developed by MD2K is to reliably quantify physical, biological, behavioral, social, and environmental factors that contribute to health and disease risk. The research conducted by MD2K is targeted at improving health through early detection of adverse health events and by facilitating prevention. MD2K will make its tools, software, and training materials widely available and will also organize workshops and seminars to encourage their use by researchers and clinicians.

  11. H5MD: A structured, efficient, and portable file format for molecular data

    NASA Astrophysics Data System (ADS)

    de Buyl, Pierre; Colberg, Peter H.; Höfling, Felix

    2014-06-01

    We propose a new file format named "H5MD" for storing molecular simulation data, such as trajectories of particle positions and velocities, along with thermodynamic observables that are monitored during the course of the simulation. H5MD files are HDF5 (Hierarchical Data Format) files with a specific hierarchy and naming scheme. Thus, H5MD inherits many benefits of HDF5, e.g., structured layout of multi-dimensional datasets, data compression, fast and parallel I/O, and portability across many programming languages and hardware platforms. H5MD files are self-contained, and foster the reproducibility of scientific data and the interchange of data between researchers using different simulation programs and analysis software. In addition, the H5MD specification can serve for other kinds of data (e.g. experimental data) and is extensible to supplemental data, or may be part of an enclosing file structure.

  12. Studies of the TLR4-associated protein MD-2 using yeast-display and mutational analyses

    PubMed Central

    Mattis, Daiva M.; Chervin, Adam; Ranoa, Diana; Kelley, Stacy; Tapping, Richard; Kranz, David M.

    2015-01-01

    Bacterial lipopolysaccharide (LPS) activates the innate immune system by forming a complex with myeloid differentiation factor 2 (MD-2) and Toll-like receptor 4 (TLR4), which is present on antigen presenting cells. MD-2 plays an essential role in this activation of the innate immune system as a member of the ternary complex, TLR4:MD-2:LPS. With the goal of further understanding the molecular details of the interaction of MD-2 with LPS and TLR4, and possibly toward engineering dominant negative regulators of the MD-2 protein, here we subjected MD-2 to a mutational analysis using yeast display. The approach included generation of site-directed alanine mutants, and ligand-driven selections of MD-2 mutant libraries. Our findings showed that: 1) proline mutations in the F119-K132 loop that binds LPS were strongly selected for enhanced yeast surface stability, 2) there was a preference for positive-charged side chains (R/K) at residue 120 for LPS binding, and negative-charged side chains (D/E) for TLR4 binding, 3) aromatic residues were strongly preferred at F119 and F121 for LPS binding, and 4) an MD-2 mutant (T84N/D101A/S118A/S120D/K122P) exhibited increased binding to TLR4 but decreased binding to LPS. These studies revealed the impact of specific residues and regions of MD-2 on the binding of LPS and TLR4, and they provide a framework for further directed evolution of the MD-2 protein. PMID:26320630

  13. 7 CFR 2.4 - General officers.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Civil Rights; the General Counsel; the Inspector General; the Chief Financial Officer; the Chief Information Officer; the Judicial Officer; the Director, Office of Budget and Program Analysis; the...

  14. D1-3: Marshfield Dictionary of Clinical and Translational Science (MD-CTS): An Online Reference for Clinical and Translational Science Terminology

    PubMed Central

    Finamore, Joe; Ray, William; Kadolph, Chris; Rastegar-Mojarad, Majid; Ye, Zhan; Jacqueline, Bohne; Tachinardi, Umberto; Mendonça, Eneida; Finnegan, Brian; Bartkowiak, Barbara; Weichelt, Bryan; Lin, Simon

    2014-01-01

    Background/Aims New terms are rapidly appearing in the literature and practice of clinical medicine and translational research. To catalog real-world usage of medical terms, we report the first construction of an online dictionary of clinical and translational medicinal terms, which are computationally generated in near real-time using a big data approach. This project is NIH CTSA-funded and developed by the Marshfield Clinic Research Foundation in conjunction with University of Wisconsin - Madison. Currently titled Marshfield Dictionary of Clinical and Translational Science (MD-CTS), this application is a Google-like word search tool. By entering a term into the search bar, MD-CTS will display that term’s definition, usage examples, contextual terms, related images, and ontological information. A prototype is available for public viewing at http://spellchecker.mfldclin.edu/. Methods We programmatically derived the lexicon for MD-CTS from scholarly communications by parsing through 15,156,745 MEDLINE abstracts and extracting all of the unique words found therein. We then ran this list through several filters in order to remove words that were not relevant for searching, such as common English words and numeric expressions. We then loaded the resulting 1,795,769 terms into SQL tables. Each term is cross-referenced with every occurrence in all abstracts in which it was found. Additional information is aggregated from Wiktionary, Bioportal, and Wikipedia in real-time and displayed on-screen. From this lexicon we created a supplemental dictionary resource (updated quarterly) to be used in Microsoft Office® products. Results We evaluated the utility of MD-CTS by creating a list of 100 words derived from recent clinical and translational medicine publications in the week of July 22, 2013. We then performed comparative searches for each term with Taber’s Cyclopedic Medical Dictionary, Stedman’s Medical Dictionary, Dorland’s Illustrated Medical Dictionary, Medical

  15. Front Range Branch Officers

    NASA Astrophysics Data System (ADS)

    The Front Range Branch of AGU has installed officers for 1990: Ray Noble, National Center for Atmospheric Research, chair; Sherry Oaks, U.S. Geological Survey, chair-elect; Howard Garcia, NOAA, treasurer; Catharine Skokan, Colorado School of Mines, secretary. JoAnn Joselyn of NOAA is past chair. Members at large are Wallace Campbell, NOAA; William Neff, USGS; and Stephen Schneider, NCAR.

  16. Office of Cancer Genomics |

    Cancer.gov

    The mission of the NCI’s Office of Cancer Genomics (OCG) is to enhance the understanding of the molecular mechanisms of cancer, advance and accelerate genomics science and technology development, and efficiently translate the genomics data to improve cancer research, prevention, early detection, diagnosis and treatment.

  17. The Mindful Development Officer

    ERIC Educational Resources Information Center

    Taft, Deb

    2012-01-01

    Delivering on a commitment to diversity in schools, colleges, and universities is a living, breathing endeavor for many members of the advancement community. While a diversity leadership agenda is set clearly from the top, advancement officers can and must play a critical role in this arena. Effective development and alumni leaders are uniquely…

  18. Troubleshooting in Medical Offices

    PubMed Central

    Gillespie, A. B.

    1977-01-01

    Physicians usually go into practice with little or no instruction in how to manage their business affairs or organize their offices. Many questions, such as where to practice, whether to join a group and whether to incorporate, must be answered. Several sources of help are available, but nothing substitutes for knowledge of the basic principles outlined in this article.

  19. Financing medical office buildings.

    PubMed

    Blake, J W

    1995-01-01

    This article discusses financing medical office buildings. In particular, financing and ownership options from a not-for-profit health care system perspective are reviewed, including use of tax-exempt debt, taxable debt, limited partnerships, sale, and real estate investment trusts (REITs).

  20. Office of the Ombudsman.

    ERIC Educational Resources Information Center

    Office of Federal Student Aid (ED), Washington, DC.

    This pamphlet describes the Federal Student Aid Ombudsman, an impartial resource to help customers resolve student loan concerns when other approaches fail. The ombudsman helps resolve discrepancies in loan balances and payments, and helps customers understand interest and collection charges. The office helps resolve issues related to income tax…

  1. Teamwork Improves Office Climate.

    ERIC Educational Resources Information Center

    Winck, Susan K.

    1993-01-01

    The Smeal College of Business Administration at the Pennsylvania State University selected its advising center as the pilot unit for a continuous quality improvement project using Total Quality Management principles. It was found that a quality improvement culture evolves when team practices are carried into the everyday office environment.…

  2. Impressions of Psychotherapists' Offices

    ERIC Educational Resources Information Center

    Nasar, Jack L.; Devlin, Ann Sloan

    2011-01-01

    For counseling settings, research suggests that softness, personalization, and order might affect the experience and the perceived expertness, trustworthiness, and social attractiveness of the therapist. This article discusses exploratory studies on college students' perception of the counseling office environment and whether the likely client…

  3. Cooperative Office Education Manual.

    ERIC Educational Resources Information Center

    Clemson Univ., SC. Vocational Education Media Center.

    This manual, intended for inexperienced and experienced coordinators, school administrators, and guidance personnel, is designed to provide practical suggestions for initiating, developing, operating, coordinating, improving, and evaluating cooperative office education programs. Major content is presented primarily in outline form under the…

  4. Reception and office organisation.

    PubMed

    Wilkinson, M D

    1989-05-20

    The reception area is central to efficient administrative procedures and is the embodiment of the style of a practice as regularly seen by every patient. Planning a reception office is not difficult but it should be done carefully to ensure that it is efficient and cost effective. In the second of his articles on practice management, Michael Wilkinson looks at the essentials.

  5. Electroporation of archaeal lipid membranes using MD simulations.

    PubMed

    Polak, Andraž; Tarek, Mounir; Tomšič, Matija; Valant, Janez; Ulrih, Nataša Poklar; Jamnik, Andrej; Kramar, Peter; Miklavčič, Damijan

    2014-12-01

    Molecular dynamics (MD) simulations were used to investigate the electroporation of archaeal lipid bilayers when subjected to high transmembrane voltages induced by a charge imbalance, mimicking therefore millisecond electric pulse experiments. The structural characteristics of the bilayer, a 9:91 mol% 2,3-di-O-sesterterpanyl-sn-glicerol-1-phospho-myo-inositol (AI) and 2,3-di-O-sesterterpanyl-sn-glicerol-1-phospho-1'(2'-O-α-D-glucosyl)-myo-inositol (AGI) were compared to small angle X-ray scattering data. A rather good agreement of the electron density profiles at temperatures of 298 and 343 K was found assessing therefore the validity of the protocols and force fields used in simulations. Compared to dipalmitoyl-phosphatidylcholine (DPPC), the electroporation threshold for the bilayer was found to increase from ~2 V to 4.3 V at 323 K, and to 5.2 V at 298 K. Comparing the electroporation thresholds of the archaeal lipids to those of simple diphytanoyl-phosphatidylcholine (DPhPC) bilayers (2.5 V at 323 K) allowed one to trace back the stability of the membranes to the structure of their lipid head groups. Addition of DPPC in amounts of 50 mol% to the archaeal lipid bilayers decreases their stability and lowers the electroporation thresholds to 3.8 V and 4.1 V at respectively 323 and 298 K. The present study therefore shows how membrane compositions can be selected to cover a wide range of responses to electric stimuli. This provides new routes for the design of liposomes that can be efficiently used as drug delivery carriers, as the selection of their composition allows one to tune in their electroporation threshold for subsequent release of their load.

  6. Apple F-Box Protein MdMAX2 Regulates Plant Photomorphogenesis and Stress Response

    PubMed Central

    An, Jian-Ping; Li, Rui; Qu, Feng-Jia; You, Chun-Xiang; Wang, Xiao-Fei; Hao, Yu-Jin

    2016-01-01

    MAX2 (MORE AXILLARY GROWTH2) is involved in diverse physiological processes, including photomorphogenesis, the abiotic stress response, as well as karrikin and strigolactone signaling-mediated shoot branching. In this study, MdMAX2, an F-box protein that is a homolog of Arabidopsis MAX2, was identified and characterized. Overexpression of MdMAX2 in apple calli enhanced the accumulation of anthocyanin. Ectopic expression of MdMAX2 in Arabidopsis exhibited photomorphogenesis phenotypes, including increased anthocyanin content and decreased hypocotyl length. Further study indicated that MdMAX2 might promote plant photomorphogenesis by affecting the auxin signaling as well as other plant hormones. Transcripts of MdMAX2 were noticeably up-regulated in response to NaCl and Mannitol treatments. Moreover, compared with the wild-type, the MdMAX2-overexpressing apple calli and Arabidopsis exhibited increased tolerance to salt and drought stresses. Taken together, these results suggest that MdMAX2 plays a positive regulatory role in plant photomorphogenesis and stress response. PMID:27909441

  7. 76 FR 5391 - Office of Biotechnology Activities, Office of Science Policy, Office of the Director

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-31

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Office of Biotechnology Activities, Office of Science Policy, Office of the Director Amended Notice of Meeting Notice is hereby given of a change in...

  8. Milestone report on MD potential development for uranium silicide

    SciTech Connect

    Yu, Jianguo; Zhang, Yongfeng; Hales, Jason Dean

    2016-03-01

    This report summarizes the progress on the interatomic potential development of triuranium-disilicide (U3Si2) for molecular dynamics (MD) simulations. The development is based on the Tersoff type potentials for single element U and Si. The Si potential is taken from the literature and a Tersoff type U potential is developed in this project. With the primary focus on the U3Si2 phase, some other U-Si systems such as U3Si are also included as a test of the transferability of the potentials for binary U-Si phases. Based on the potentials for unary U and Si, two sets of parameters for the binary U-Si system are developed using the Tersoff mixing rules and the cross-term fitting, respectively. The cross-term potential is found to give better results on the enthalpy of formation, lattice constants and elastic constants than those produced by the Tersoff mixing potential, with the reference data taken from either experiments or density functional theory (DFT) calculations. In particular, the results on the formation enthalpy and lattice constants for the U3Si2 phase and lattice constants for the high temperature U3Si (h-U3Si) phase generated by the cross-term potential agree well with experimental data. Reasonable agreements are also reached on the elastic constants of U3Si2, on the formation enthalpy for the low temperature U3Si (m-U3Si) and h-U3Si phases, and on the lattice constants of m-U3Si phase. All these phases are predicted to be mechanically stable. The unary U potential is tested for three metallic U phases (α, β, γ). The potential is found capable to predict the cohesive energies well against experimental data for all three phases. It matches reasonably with previous experiments on the lattice constants and elastic constants of αU.

  9. 75 FR 15713 - Office of Biotechnology Activities; Office of Science Policy; Office of the Director; Notice of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-30

    ... HUMAN SERVICES National Institutes of Health Office of Biotechnology Activities; Office of Science..., Advisory Committee Coordinator, Office of Biotechnology Activities, Office of Science Policy, Office of the... of Biotechnology Activities, National Institutes of Health. BILLING CODE 4140-01-P...

  10. Marine Officer Attrition Model.

    DTIC Science & Technology

    1984-06-01

    DISTRISUTION STATEMEANT (.1 lAg.Rpo) * Approved for public release; Distribution unlimited * I7. DISTRIGUTION STATEMENT (of the abstract @new A 01.0 2 ...Informat y Scitnces 2 ’I.I AISISACT Fredicting officer attrition is a major difficulty in the Elamaing, Programming, and Budgeting Process. The marine...For °. **** A vjl lbiitv Cod*S i S z,.npl/r. .** ~. .~d .’. **~ * * % >.,. >~. . * * ~****** * *** *- **.*%** 21JBLE CP CGITZITS 2 |2157CDOCTIONl

  11. 78 FR 52109 - Proposed Amendment of Class D and E Airspace, and Establishment of Class E Airspace; Salisbury, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-22

    ... 700 feet or more above the surface of the earth. * * * * * AEA MD E5 Salisbury, MD Salisbury-Ocean..., and establish Class E airspace at Salisbury-Ocean City Wicomico Regional Airport, Salisbury, MD, due... Federal Regulations (14 CFR) part 71 to amend Class D and Class E airspace at Salisbury-Ocean...

  12. 75 FR 68970 - Amendment of Using Agency for Restricted Areas R-4002, R-4005, R-4006 and R-4007; MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-10

    ... Restricted Areas R-4002, R-4005, R- 4006 and R-4007; MD AGENCY: Federal Aviation Administration (FAA), DOT... restricted areas R-4002, Bloodsworth Island, MD; and R-4005, R-4006 and R-4007, Patuxent River, MD to ``U.S... areas R-4002, R-4005, R-4006 and R-4007 in Maryland, in order to reflect the correct......

  13. Identification of a novel human MD-2 splice variant that negatively regulates Lipopolysaccharide-induced TLR4 signaling.

    PubMed

    Gray, Pearl; Michelsen, Kathrin S; Sirois, Cherilyn M; Lowe, Emily; Shimada, Kenichi; Crother, Timothy R; Chen, Shuang; Brikos, Constantinos; Bulut, Yonca; Latz, Eicke; Underhill, David; Arditi, Moshe

    2010-06-01

    Myeloid differentiation factor 2 (MD-2) is a secreted gp that assembles with TLR4 to form a functional signaling receptor for bacterial LPS. In this study, we have identified a novel alternatively spliced isoform of human MD-2, termed MD-2 short (MD-2s), which lacks the region encoded by exon 2 of the MD-2 gene. Similar to MD-2, MD-2s is glycosylated and secreted. MD-2s also interacted with LPS and TLR4, but failed to mediate LPS-induced NF-kappaB activation and IL-8 production. We show that MD-2s is upregulated upon IFN-gamma, IL-6, and TLR4 stimulation and negatively regulates LPS-mediated TLR4 signaling. Furthermore, MD-2s competitively inhibited binding of MD-2 to TLR4. Our study pinpoints a mechanism that may be used to regulate TLR4 activation at the onset of signaling and identifies MD-2s as a potential therapeutic candidate to treat human diseases characterized by an overly exuberant or chronic immune response to LPS.

  14. Automated office blood pressure.

    PubMed

    Myers, Martin G; Godwin, Marshall

    2012-05-01

    Manual blood pressure (BP) is gradually disappearing from clinical practice with the mercury sphygmomanometer now considered to be an environmental hazard. Manual BP is also subject to measurement error on the part of the physician/nurse and patient-related anxiety which can result in poor quality BP measurements and office-induced (white coat) hypertension. Automated office (AO) BP with devices such as the BpTRU (BpTRU Medical Devices, Coquitlam, BC) has already replaced conventional manual BP in many primary care practices in Canada and has also attracted interest in other countries where research studies using AOBP have been undertaken. The basic principles of AOBP include multiple readings taken with a fully automated recorder with the patient resting alone in a quiet room. When these principles are followed, office-induced hypertension is eliminated and AOBP exhibits a much stronger correlation with the awake ambulatory BP as compared with routine manual BP measurements. Unlike routine manual BP, AOBP correlates as well with left ventricular mass as does the awake ambulatory BP. AOBP also simplifies the definition of hypertension in that the cut point for a normal AOBP (< 135/85 mm Hg) is the same as for the awake ambulatory BP and home BP. This article summarizes the currently available evidence supporting the use of AOBP in routine clinical practice and proposes an algorithm in which AOBP replaces manual BP for the diagnosis and management of hypertension.

  15. 40. PRESIDENT, OFFICERS AND DEPARTMENT HEADS MEET IN PRESIDENT'S OFFICE, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    40. PRESIDENT, OFFICERS AND DEPARTMENT HEADS MEET IN PRESIDENT'S OFFICE, PUBLISHED IN A BOOK, 'A SYMBOL OF SAFETY' BY HARRY CHASE BREARLEY, 1923 - Underwriters' Laboratories, 207-231 East Ohio Street, Chicago, Cook County, IL

  16. 20. OFFICE AT NORTH END OF SECOND FLOOR, ADMINISTRATIVE OFFICES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. OFFICE AT NORTH END OF SECOND FLOOR, ADMINISTRATIVE OFFICES SECTION. VIEW TO SOUTHEAST. - Ford Motor Company Long Beach Assembly Plant, Assembly Building, 700 Henry Ford Avenue, Long Beach, Los Angeles County, CA

  17. Osler's Pupil, Henry W. Ochsner, MD (1877–1902): His Life, Lineage, and Death

    PubMed Central

    Mueller, Paul S.

    2007-01-01

    In multiple editions of his Principles and Practice of Medicine, a 1904 speech, and his essay “A Student Life,” Sir William Osler mentions and laments the death due to typhoid of his pupil, Henry W. Ochsner (1877–1902). Harvey Cushing, MD, in his biography of Osler, describes how deeply Osler was moved by “poor” Ochsner's death. Yet little is known about Ochsner. This article describes the life story, lineage, and death of Henry W. Ochsner, MD, a son of Swiss pioneers who settled in Waumandee, Wisconsin. He was a member of a family that includes medical luminaries (e.g., Albert J. Ochsner, MD, the famous Chicago surgeon, and Alton Ochsner, MD, the founder of the Ochsner Clinic); a brilliant student and physician; a humble and beloved fellow citizen; and a favorite pupil of Osler. PMID:21603518

  18. Annual Report 2008 -- Office of the Chief Financial Officer (OCFO)

    SciTech Connect

    Fernandez, Jeffrey

    2008-12-22

    It is with great pleasure that I present to you the 2008 Chief Financial Officer's Annual Report. The data included in this report has been compiled from the Budget Office, the Controller, Procurement and Property Management and the Sponsored Projects Office. Also included are some financial comparisons with other DOE Laboratories and a glossary of commonly used acronyms.

  19. VIEW EAST, WEST SIDE OF TWOSTORY OFFICE BUILDING, ONESTORY OFFICE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW EAST, WEST SIDE OF TWO-STORY OFFICE BUILDING, ONE-STORY OFFICE BUILDING, AND HEBERTS 1949 HANGAR, AND VIEW OF SOUTH SIDE OF TWO-STORY OFFICE BUILDING AND NORTH SIDE OF HEBERTS 1949 HANGAR - Capital City Airport, Capital City Aviation, North side of Grand River Avenue, Lansing, Ingham County, MI

  20. Sustainable water recovery from oily wastewater via forward osmosis-membrane distillation (FO-MD).

    PubMed

    Zhang, Sui; Wang, Peng; Fu, Xiuzhu; Chung, Tai-Shung

    2014-04-01

    This study proposed and investigated a hybrid forward osmosis - membrane distillation (FO-MD) system for sustainable water recovery from oily wastewater by employing lab-fabricated FO and MD hollow fiber membranes. Stable oil-in-water emulsions of different concentrations with small droplet sizes (<1 μm) were firstly prepared and applied as the feed solution in the FO process. Fouling was immediately observed in the FO mode and was low on the cellulose triacetate (CTA) - based thin film composite (TFC) membranes. Moreover, slight increment of fouling was observed in the first few hours and the water flux was then stabilized over 24 h. The characterizations of water flux and solute rejection in separate FO and MD processes revealed that a high water flux, good NaCl rejection, impressively high retention of oil droplets and partial permeation of acetic acid could be achieved. Finally, an integrated FO-MD system was developed to treat the oily wastewater containing petroleum, surfactant, NaCl and acetic acid at 60 °C in the batch mode. The water flux in FO undergoes three-stage decline due to fouling and reduction in osmotic driving force, but is quite stable in MD regardless of salt concentration. Oily wastewater with relatively high salinity could be effectively recovered by the FO-MD hybrid system while maintaining large water flux, at least 90% feed water recovery could be readily attained with only trace amounts of oil and salts, and the draw solution was re-generated for the next rounds of FO-MD run. Interestingly, significant amount of acetic acid was also retained in the permeate for further reuse as a chemical additive during the production of crude oil. The work has demonstrated that not only water but also organic additives in the wastewater could be effectively recovered by FO-MD systems for reuse or other utilizations.

  1. MD2 expression is reduced in large airways of smokers and COPD smokers.

    PubMed

    Pace, Elisabetta; Ferraro, Maria; Chiappara, Giuseppina; Vitulo, Patrizio; Pipitone, Loredana; Di Vincenzo, Serena; Gjomarkaj, Mark

    2015-09-01

    Toll-like receptor 4 (TLR4) signaling requires a number of accessory proteins to initiate a signal. MD-2 is one of the accessory proteins with a relevant role in lipopolysaccharide responses. Although cigarette smoke increases TLR4 expression, TLR4 signaling is altered in smokers and in smokers COPD patients. The main aims of this study were to explore whether MD2 is altered in large and small airways of COPD and of smokers without COPD. The expression of MD2 ex vivo was assessed by immunohistochemistry in surgical specimens from current smokers COPD (s-COPD; n = 14), smokers without COPD (S; n = 7), and from non-smoker non-COPD subjects (C; n = 11. The in vitro effects of cigarette smoke extracts on the MD2 expression in a human bronchial epithelial cell line (16-HBE) were also assessed by flow cytometry. MD2 is reduced in the epithelium and in the submucosa in large airways but not in the epithelium and in the submucosa in small airways of smokers and of s-COPD. The expression of MD2 in the submucosa of the large airways is significantly higher in comparison to the submucosa of the small airways in all the studied groups. In vitro, cigarette smoke is able to increase TLR4 but it reduces MD2 in a dose-dependent manner in bronchial epithelial cells. Cigarette smoke may alter innate immune responses reducing the expression of the MD2, a molecule with an important role in TLR4 signaling.

  2. The School Office: An Overview.

    ERIC Educational Resources Information Center

    Hudson, Randy

    2000-01-01

    Presents an overview of the fundamental principles of school office design that remain constant despite changes in building technologies, and technological and spatial flexibility. Principles discussed include the school office and traffic patterns, security, and visitor reception requirements. (GR)

  3. The Mechanization of Office Work.

    ERIC Educational Resources Information Center

    Giuliano, Vincent E.

    1982-01-01

    Discusses how technology is changing the nature of office work by introducing new information-processing machines, programs for operating them, and communications systems for interconnecting them. Includes diagrams of preindustrial, industrial, and information-age offices. (Author/JN)

  4. Apple autophagy-related protein MdATG3s afford tolerance to multiple abiotic stresses.

    PubMed

    Wang, Ping; Sun, Xun; Jia, Xin; Ma, Fengwang

    2017-03-01

    The efficient degradation system of autophagy in plant cells has important roles in removing and recycling intracellular components during normal development or under environmental stresses. Formation of autophagosomes requires the conjugation of ubiquitin-like protein ATG8 to phosphatidylethanolamine (PE). We isolated two ubiquitin-conjugating enzyme E2-like ATG3 homologues from Malus domestica - MdATG3a and MdATG3b - that are crucial for ATG8-PE conjugation. Both share a conserved N-terminal, as well as the catalytic and C-terminal domains of ATG3 with HPC and FLKF motifs. Each promoter was isolated from genomic DNA and contained several cis-acting elements that are involved in responses to environmental stresses or hormones. In addition to having the same cellular localization in the nucleus and cytoplasm, MdATG3a and MdATG3b showed similar expression patterns toward leaf senescence, nitrogen starvation, drought, salinity, and oxidative stress at the transcriptional level. Ectopic expression of either in Arabidopsis conferred tolerance to osmotic or salinity stress and also improved growth performance under nitrogen- or carbon-starvation. Callus lines of 'Orin' apple that over-expressed MdATG3b also displayed better growth performance when nutrient supplies were limited. These overall results demonstrate that, as important autophagy genes, overexpression of MdATG3s can afford tolerance to multiple abiotic stresses at the cellular and whole-plant level.

  5. End-to-End Rate-Distortion Optimized MD Mode Selection for Multiple Description Video Coding

    NASA Astrophysics Data System (ADS)

    Heng, Brian A.; Apostolopoulos, John G.; Lim, Jae S.

    2006-12-01

    Multiple description (MD) video coding can be used to reduce the detrimental effects caused by transmission over lossy packet networks. A number of approaches have been proposed for MD coding, where each provides a different tradeoff between compression efficiency and error resilience. How effectively each method achieves this tradeoff depends on the network conditions as well as on the characteristics of the video itself. This paper proposes an adaptive MD coding approach which adapts to these conditions through the use of adaptive MD mode selection. The encoder in this system is able to accurately estimate the expected end-to-end distortion, accounting for both compression and packet loss-induced distortions, as well as for the bursty nature of channel losses and the effective use of multiple transmission paths. With this model of the expected end-to-end distortion, the encoder selects between MD coding modes in a rate-distortion (R-D) optimized manner to most effectively tradeoff compression efficiency for error resilience. We show how this approach adapts to both the local characteristics of the video and network conditions and demonstrates the resulting gains in performance using an H.264-based adaptive MD video coder.

  6. Army Officer Development: Historical Context

    DTIC Science & Technology

    2010-04-01

    its officers. The result was the landmark Review of Education and Training for Officers ( RETO ), a study that set the direction for the school system...and the officer development process for the rest of the Cold War and beyond. 37 The RETO report stressed the importance of officers mastering...the RETO recommendations for the War College’s curriculum with those of the earlier Haines Board brings their differences into stark relief. As noted

  7. Ergonomics in the office environment

    NASA Technical Reports Server (NTRS)

    Courtney, Theodore K.

    1993-01-01

    Perhaps the four most popular 'ergonomic' office culprits are: (1) the computer or visual display terminal (VDT); (2) the office chair; (3) the workstation; and (4) other automated equipment such as the facsimile machine, photocopier, etc. Among the ergonomics issues in the office environment are visual fatigue, musculoskeletal disorders, and radiation/electromagnetic (VLF,ELF) field exposure from VDT's. We address each of these in turn and then review some regulatory considerations regarding such stressors in the office and general industrial environment.

  8. Why Black Officers Still Fail

    DTIC Science & Technology

    2010-03-01

    White youth is smaller than it once was. They all pointed to the fact that today’s youth, both white and black, tend to be attracted to rap music and...papers touching on the experiences of black officers as they relate to representation, promotions, influence , and culture. They can best be...they relate to Black officer representation in the Army, Black officer promotion rates, Black officer influence on policy and decision making, black

  9. Cell lines, Md108 and Md66, from the hemocytes of Malacosoma disstria (Lepidoptera) display aspects of plasma-free innate non-self activities.

    PubMed

    Lapointe, Jason F; Dunphy, Gary B; Giannoulis, Paschalis; Mandato, Craig A; Nardi, James B; Gharib, Osama H; Niven, Donald F

    2011-11-01

    The innate non-self response systems of the deciduous tree pest, the forest tent caterpillar, Malacosoma disstria has been documented by us in terms of in vitro and in vivo reactions towards the Gram-positive nonpathogenic bacterium, Bacillus subtilis and Gram-negative pathogenic microbe, Xenorhabdus nematophila and their respective surface antigens, lipopoteichoic acids (LTA) and lipopolysaccharides (LPS). These studies, often conducted in whole and diluted hemolymph, preclude examination of plasma-free cellular (hemocyte) responses. Plasma-free hemocytes as primary cultures are difficult to obtain. The floating cell line Md66 and attached cell line Md108 from M. disstria hemocytes were examined as a model for plasma-free M. disstria hemocyte non-self responses. Herein, it was established that although both lines differed from each other and from the primary hemocyte cultures of M. disstria in growth parameters, cell composition and sizes both cell lines displayed granular cell-like (GL) cells and plasmatocyte-like (PL) cells according to morphological criteria and to some extent antigenic similarities based on labeling with anti-Chrysodeixis includens hemocyte monoclonal antibodies. Hemocyte-specific neuroglian-like protein was detected on cells of both cell lines and in the primary hemocyte cultures albeit with staining patterns differing according to culture and cell types, confluency levels and cell-cell adhesion. Both cell lines bound B. subtilis and X. nematophila, the reaction extent varying with the cell line and its cell types. LPS damaged both cell types in the two cell lines whereas LTA enhanced the adhesion of Md66 GL cells to flask surfaces followed by PL cell adhesion. PL cells of both lines, like the primary cultures, phagocytosed FITC-labeled B. subtilis; only Md108 GL cells phagocytosed B. subtilis. In either case phagocytosis was always less in frequency and intensity than the primary cultures. Proteins released from the cell lines differed in

  10. Leasing physician office space.

    PubMed

    Murray, Charles

    2009-01-01

    When leasing office space, physicians should determine the effective lease rate (ELR) for each building they are considering before making a selection. The ELR is based on a number of factors, including building quality, building location, basic form of lease agreement, rent escalators and add-on factors in the lease, tenant improvement allowance, method of square footage measurement, quality of building management, and other variables. The ELR enables prospective physician tenants to accurately compare lease rates being quoted by building owners and to make leasing decisions based on objective criteria.

  11. Aviation Officer Requirements Study.

    DTIC Science & Technology

    1982-08-31

    In the dynamics of the planning process, when potential force level changes are fre- quent, these computations are tedious and subject to error . Since...was tedious and subject to both computational and entry errors . The current ver- sion of the model corrects this deficiency. The Aviation Officer...k.N )) ,iFY(Fr\\) ,NniALT c nTn ,TIVP.W £-430 PROJ3 = POS-:(PRn1 Z=m4m) f-440 PROC, = Pnr3(PrOnf2="-) E.4! - INI T (1-F(20) )TR(PrOFL,. 137> C,460 = TIPO

  12. Is the Office Hour Obsolete?

    ERIC Educational Resources Information Center

    Behrens, Susan

    2013-01-01

    A colleague can't make a coffee date at a time the author proposes because it would conflict with his office hour. No student has actually made an appointment with him during the hour, but he is committed to being in his office as promised in case someone drops by. The author's reaction to her colleague's faithfulness to his posted office hour…

  13. Office Workers Stress Survey Results.

    ERIC Educational Resources Information Center

    North Carolina Occupational Safety and Health Project, Durham.

    A survey of office workers employed by North Carolina telephone companies was conducted to determine the extent and types of health problems experienced by office workers who use video display terminals (VDTs). Data were gathered by questionnaires mailed to 2,478 office workers, with 966 responses. Questions concerning a wide range of health…

  14. 75 FR 63753 - Family Offices

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-18

    ... COMMISSION 17 CFR Part 275 RIN 3235-AK66 Family Offices AGENCY: Securities and Exchange Commission. ACTION... define ``family offices'' that would be excluded from the definition of an investment adviser under the... Text of Proposed Rule I. Background ``Family offices'' are entities established by wealthy families...

  15. Radioiodination of an endotoxin·MD-2 complex generates a novel sensitive, high affinity ligand for TLR4

    PubMed Central

    Teghanemt, Athmane; Weiss, Jerrold P.; Gioannini, Theresa L.

    2013-01-01

    A purified complex of metabolically labeled endotoxin ([3H] lipooligosaccharide, LOS) and insect-cell derived recombinant human myeloid differentiation factor 2, (MD-2), [3H] LOS·MD-2, has been used to demonstrate pM affinity binding interactions with soluble Toll-like receptor 4 ectodomain (TLR4ecd). Measurement of the binding parameters of membrane-bound TLR4 has been hampered by the paucity of TLR4 on cell surfaces and inadequate sensitivity of available reagents. We took advantage of the stability of endotoxin·MD-2 and tyrosine(s) present on the surface of MD-2 to radioiodinate LOS·MD-2. Radioiodinated LOS·MD-2 generated a reagent with an estimated 1:1 molar ratio of [125I] to sMD-2 with 20-fold higher specific radioactivity and TLR4-activating properties comparable to metabolically labeled LOS·MD-2. LOS·MD-2[125I] and [3H]LOS·MD-2 have similar affinities for soluble FLAGTLR4ecd and for membrane-bound TLR4 in transiently transfected HEK293T/TLR4 cells. In a similar dose-dependent manner, sMD-2 and LOS·MD-2 inhibit LOS·MD-2[125I] binding to TLR4 indicating the pM affinity binding of LOS·MD-2[125I] is agonist-independent. LOS·MD-2[125I] allowed measurement of low levels of cell-surface human or murine TLR4 expressed by stable cell lines (2,000–3,000 sites/cell) and quantitatively measures low levels of “MD-2-free” TLR4 (est. 250 molecules/cell) in cells co-expressing TLR4 and MD-2. Occupation of 50–100 TLR4/cell by LOS·MD-2 is sufficient to trigger measurable TLR4-dependent cell activation. LOS·MD-2[125I] provides a powerful reagent to measure quantitatively functional cell-surface TLR4 in human and murine cells, including cells where surface TLR4 are potentially functionally significant but too low to detect by other methods. PMID:23439691

  16. Current Tools and Methods in Molecular Dynamics (MD) Simulations for Drug Design.

    PubMed

    Hernández-Rodríguez, Maricarmen; Rosales-Hernández, Martha C; Mendieta-Wejebe, Jessica E; Martínez-Archundia, Marlet; Basurto, José Correa

    2016-01-01

    Molecular Dynamics (MD) simulations is a computational method that employs Newton's laws to evaluate the motions of water, ions, small molecules, and macromolecules or more complex systems, for example, whole viruses, to reproduce the behavior of the biological environment, including water molecules and lipid membranes. Specifically, structural motions, such as those that are dependent of the temperature and solute/ solvent are very important to study the recognition pattern of ligandprotein or protein-protein complexes, in that sense, MD simulations are very useful because these motions can be modeled using this methodology. Furthermore, MD simulations for drug design provide insights into the structural cavities required to design novel structures with higher affinity to the target. Also, the employment of MD simulations to drug design can help to refine the three-dimensional (3D) structure of targets in order to obtain a better sampling of the binding poses and more reliable affinity values with better structural advantages, because they incorporate some biological conditions that include structural motions compared to traditional docking procedures. This work analyzes the concepts and applicability of MD simulations for drug design because molecular structural motions are considered, and these help to identify hot spots, decipher structural details in the reported protein sites, as well as to eliminate sites that could be structural artifacts which could be originated from the structural characterization conditions from MD. Moreover, better free energy values for protein ligand recognition can also be obtained, and these can be validated under experimental procedures due to the robustness of the MD simulation methods.

  17. Endotoxin responsiveness of human airway epithelia is limited by low expression of MD-2.

    PubMed

    Jia, Hong Peng; Kline, Joel N; Penisten, Andrea; Apicella, Michael A; Gioannini, Theresa L; Weiss, Jerrold; McCray, Paul B

    2004-08-01

    The expression of inducible antimicrobial peptides, such as human beta-defensin-2 (HBD-2) by epithelia, comprises a component of innate pulmonary defenses. We hypothesized that HBD-2 induction in airway epithelia is linked to pattern recognition receptors such as the Toll-like receptors (TLRs). We found that primary cultures of well-differentiated human airway epithelia express the mRNA for TLR-4, but little or no MD-2 mRNA, and display little HBD-2 expression in response to treatment with purified endotoxin +/- LPS binding protein (LBP) and soluble CD14. Expression of endogenous MD-2 by transduction of airway epithelial cells with an adenoviral vector encoding MD-2 or extracellular addition of recombinant MD-2 both increased the responses of airway epithelia to endotoxin + LBP and sCD14 by >100-fold, as measured by NF-kappaB-luciferase activity and HBD-2 mRNA expression. MD-2 mRNA could be induced in airway epithelia by exposure of these cells to specific bacterial or host products (e.g., killed Haemophilus influenzae, the P6 outer membrane protein from H. influenzae, or TNF-alpha + IFN-gamma). These findings suggest that MD-2, either coexpressed with TLR-4 or secreted when produced in excess of TLR-4 from neighboring cells, is required for airway epithelia to respond sensitively to endotoxin. The regulation of MD-2 expression in airway epithelia and pulmonary macrophages may serve as a means to modify endotoxin responsiveness in the airway.

  18. Badge Office Process Analysis

    SciTech Connect

    Haurykiewicz, John Paul; Dinehart, Timothy Grant; Parker, Robert Young

    2016-05-12

    The purpose of this process analysis was to analyze the Badge Offices’ current processes from a systems perspective and consider ways of pursuing objectives set forth by SEC-PS, namely increased customer flow (throughput) and reduced customer wait times. Information for the analysis was gathered for the project primarily through Badge Office Subject Matter Experts (SMEs), and in-person observation of prevailing processes. Using the information gathered, a process simulation model was constructed to represent current operations and allow assessment of potential process changes relative to factors mentioned previously. The overall purpose of the analysis was to provide SEC-PS management with information and recommendations to serve as a basis for additional focused study and areas for potential process improvements in the future.

  19. INEL Sample Management Office

    SciTech Connect

    Watkins, C.

    1994-12-31

    The Idaho National Engineering Laboratory (INEL) Sample Management Office (SMO) was formed as part of the EG&G Idaho Environmental Restoration Program (ERP) in June, 1990. Since then, the SMO has been recognized and sought out by other prime contractors and programs at the INEL. Since December 1991, the DOE-ID Division Directors for the Environmental Restoration Division and Waste Management Division supported the expansion of the INEL ERP SMO into the INEL site wide SMO. The INEL SMO serves as a point of contact for multiple environmental analytical chemistry and laboratory issues (e.g., capacity, capability). The SMO chemists work with project managers during planning to help develop data quality objectives, select appropriate analytical methods, identify special analytical services needs, identify a source for the services, and ensure that requirements for sampling and analysis (e.g., preservations, sample volumes) are clear and technically accurate. The SMO chemists also prepare work scope statements for the laboratories performing the analyses.

  20. The chief strategy officer.

    PubMed

    Breene, R Timothy S; Nunes, Paul F; Shill, Walter E

    2007-10-01

    They're nominally and ultimately responsible for strategy, but today's CEOs have less and less time to devote to it. As a result, CEOs are appointing "chief strategy officers"--executives specifically tasked with creating, communicating, executing, and sustaining a company's strategic initiatives. In this article, three authors from Accenture share the results of their research on this emerging organizational role. The typical CSO or top strategy executive is not a pure strategist, conducting long-range planning in relative isolation. Most CSOs consider themselves doers first, with the mandate, credentials, and desire to act as well as advise. They are seasoned executives with a strong strategy orientation who have usually worn many operations hats before taking on the role. Strategy executives are charged with three critical jobs that together form the very definition of strategy execution. First, they must clarify the company's strategy for themselves and for every business unit and function, ensuring that all employees understand the details of the strategic plan and how their work connects to corporate goals. Second, CSOs must drive immediate change. The focus of the job almost always quickly evolves from creating shared alignment around a vision to riding herd on the ensuing change effort. Finally, a CSO must drive decision making that sustains organizational change. He or she must be that person who, in the CEO's stead, can walk into any office and test whether the decisions being made are aligned with the strategy and are creating the desired results. When decisions below the executive suite aren't being made in accordance with strategy, much of the CSO's job involves learning why and quickly determining whether to stay the course or change tack.

  1. Ubiquitination-Related MdBT Scaffold Proteins Target a bHLH Transcription Factor for Iron Homeostasis1[OPEN

    PubMed Central

    Zhao, Qiang; Wang, Qing-Jie; Wang, Xiao-Fei; You, Chun-Xiang

    2016-01-01

    Iron (Fe) homeostasis is crucial for plant growth and development. A network of basic helix-loop-helix (bHLH) transcription factors positively regulates Fe uptake during iron deficiency. However, their up-regulation or overexpression leads to Fe overload and reactive oxygen species generation, thereby damaging the plants. Here, we found that two BTB/TAZ proteins, MdBT1 and MdBT2, interact with the MbHLH104 protein in apple. In addition, the function of MdBT2 was characterized as a regulator of MdbHLH104 degradation via ubiquitination and the 26S proteasome pathway, thereby controlling the activity of plasma membrane H+-ATPases and the acquisition of iron. Furthermore, MdBT2 interacted with MdCUL3 proteins, which were required for the MdBT2-mediated ubiquitination modification of MdbHLH104 and its degradation. In sum, our findings demonstrate that MdBT proteins interact with MdCUL3 to bridge the formation of the MdBTsMdCUL3 complex, which negatively modulates the degradation of the MdbHLH104 protein in response to changes in Fe status to maintain iron homeostasis in plants. PMID:27660166

  2. MdMYB1 Regulates Anthocyanin and Malate Accumulation by Directly Facilitating Their Transport into Vacuoles in Apples.

    PubMed

    Hu, Da-Gang; Sun, Cui-Hui; Ma, Qi-Jun; You, Chun-Xiang; Cheng, Lailiang; Hao, Yu-Jin

    2016-03-01

    Tonoplast transporters, including proton pumps and secondary transporters, are essential for plant cell function and for quality formation of fleshy fruits and ornamentals. Vacuolar transport of anthocyanins, malate, and other metabolites is directly or indirectly dependent on the H(+)-pumping activities of vacuolar H(+)-ATPase (VHA) and/or vacuolar H(+)-pyrophosphatase, but how these proton pumps are regulated in modulating vacuolar transport is largely unknown. Here, we report a transcription factor, MdMYB1, in apples that binds to the promoters of two genes encoding the B subunits of VHA, MdVHA-B1 and MdVHA-B2, to transcriptionally activate its expression, thereby enhancing VHA activity. A series of transgenic analyses in apples demonstrates that MdMYB1/10 controls cell pH and anthocyanin accumulation partially by regulating MdVHA-B1 and MdVHA-B2. Furthermore, several other direct target genes of MdMYB10 are identified, including MdVHA-E2, MdVHP1, MdMATE-LIKE1, and MdtDT, which are involved in H(+)-pumping or in the transport of anthocyanins and malates into vacuoles. Finally, we show that the mechanism by which MYB controls malate and anthocyanin accumulation in apples also operates in Arabidopsis (Arabidopsis thaliana). These findings provide novel insights into how MYB transcription factors directly modulate the vacuolar transport system in addition to anthocyanin biosynthesis, consequently controlling organ coloration and cell pH in plants.

  3. Angiotensin II induces kidney inflammatory injury and fibrosis through binding to myeloid differentiation protein-2 (MD2)

    PubMed Central

    Xu, Zheng; Li, Weixin; Han, Jibo; Zou, Chunpeng; Huang, Weijian; Yu, Weihui; Shan, Xiaoou; Lum, Hazel; Li, Xiaokun; Liang, Guang

    2017-01-01

    Growing evidence indicates that angiotensin II (Ang II), a potent biologically active product of RAS, is a key regulator of renal inflammation and fibrosis. In this study, we tested the hypothesis that Ang II induces renal inflammatory injury and fibrosis through interaction with myeloid differentiation protein-2 (MD2), the accessory protein of toll-like receptor 4 (TLR4) of the immune system. Results indicated that in MD2−/− mice, the Ang II-induced renal fibrosis, inflammation and kidney dysfunction were significantly reduced compared to control Ang II-infused wild-type mice. Similarly, in the presence of small molecule MD2 specific inhibitor L6H21 or siRNA-MD2, the Ang II-induced increases of pro-fibrotic and pro-inflammatory molecules were prevented in tubular NRK-52E cells. MD2 blockade also inhibited activation of NF-κB and ERK. Moreover, MD2 blockade prevented the Ang II-stimulated formation of the MD2/TLR4/MyD88 signaling complex, as well as the increased surface binding of Ang II in NRK-52E cells. In addition, Ang II directly bound recombinant MD2 protein, rather than TLR4 protein. We conclude that MD2 is a significant contributor in the Ang II-induced kidney inflammatory injury in chronic renal diseases. Furthermore, MD2 inhibition could be a new and important therapeutic strategy for preventing progression of chronic renal diseases. PMID:28322341

  4. Physician offices marketing: assessing patients' views of office visits.

    PubMed

    Emmett, Dennis; Chandra, Ashish

    2010-01-01

    Physician offices often lack the sense of incorporating appropriate strategies to make their facilities as marketer of their services. The patient experience at a physician's office not only incorporates the care they receive from the physician but also the other non-healthcare related aspects, such as the behavior of non-health professionals as well as the appearance of the facility itself. This paper is based on a primary research conducted to assess what patients assess from a physician office visit.

  5. MdHB1 down-regulation activates anthocyanin biosynthesis in the white-fleshed apple cultivar 'Granny Smith'.

    PubMed

    Jiang, Yonghua; Liu, Cuihua; Yan, Dan; Wen, Xiaohong; Liu, Yanli; Wang, Haojie; Dai, Jieyu; Zhang, Yujie; Liu, Yanfei; Zhou, Bin; Ren, Xiaolin

    2017-03-06

    Coloration in apple (Malus×domestica) flesh is mainly caused by the accumulation of anthocyanin. Anthocyanin is biosynthesized through the flavonoid pathway and regulated by MYB, bHLH, and WD40 transcription factors (TFs). Here, we report that the HD-Zip I TF MdHB1 was also involved in the regulation of anthocyanin accumulation. MdHB1 silencing caused the accumulation of anthocyanin in 'Granny Smith' flesh, whereas its overexpression reduced the flesh content of anthocyanin in 'Ballerina' (red-fleshed apple). Moreover, flowers of transgenic tobacco (Nicotiana tabacum 'NC89') overexpressing MdHB1 showed a remarkable reduction in pigmentation. Transient promoter activation assays and yeast one-hybrid results indicated that MdHB1 indirectly inhibited expression of the anthocyanin biosynthetic genes encoding dihydroflavonol-4-reductase (DFR) and UDP-glucose:flavonoid 3-O-glycosyltransferase (UFGT). Yeast two-hybrid and bimolecular fluorescence complementation determined that MdHB1 acted as a homodimer and could interact with MYB, bHLH, and WD40 in the cytoplasm, consistent with its cytoplasmic localization by green fluorescent protein fluorescence observations. Together, these results suggest that MdHB1 constrains MdMYB10, MdbHLH3, and MdTTG1 to the cytoplasm, and then represses the transcription of MdDFR and MdUFGT indirectly. When MdHB1 is silenced, these TFs are released to activate the expression of MdDFR and MdUFGT and also anthocyanin biosynthesis, resulting in red flesh in 'Granny Smith'.

  6. 76 FR 77240 - Office of Biotechnology Activities, Office of Science Policy, Office of the Director; Notice of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Office of Biotechnology Activities, Office of Science..., NIH Office of Biotechnology Activities, 6705 Rockledge Drive, Suite 750, Bethesda, Maryland...

  7. 75 FR 2549 - Office of Biotechnology Activities; Office of Science Policy; Office of the Director; Notice of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-15

    ... HUMAN SERVICES National Institutes of Health Office of Biotechnology Activities; Office of Science... concerning this meeting, contact Ms. Laurie Lewallen, Advisory Committee Coordinator, Office of Biotechnology...: January 11, 2010. Kelly R. Fennington, Special Assistant to the Director, Office of...

  8. 76 FR 28793 - Office of Biotechnology Activities, Office of Science Policy, Office of the Director; Notice of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-18

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Office of Biotechnology Activities, Office of Science... Assistant, NIH Office of Biotechnology Activities, 6705 Rockledge Drive, Suite 750, Bethesda, Maryland...

  9. 76 FR 3918 - Office of Biotechnology Activities, Office of Science Policy, Office of the Director; Notice of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Office of Biotechnology Activities, Office of Science..., Bethesda, Maryland 20892. Contact Person: Ronna Hill, NSABB Program Assistant NIH Office of...

  10. 77 FR 66624 - Office of Biotechnology Activities, Office of Science Policy, Office of the Director; Notice of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-06

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Office of Biotechnology Activities, Office of Science... 20892. Contact Person: Ronna Hill, NSABB Program Assistant, NIH Office of Biotechnology Activities,...

  11. Opinion of stakeholders on existing curriculum for postgraduate (MD) course in Pharmacology: A survey

    PubMed Central

    Badyal, Dinesh K.; Daniel, Sujit R.

    2016-01-01

    Objectives: To survey the opinion about various curricular components of Doctor of Medicine (MD) pharmacology curriculum in India by stakeholders, including faculty and students. Materials and Methods: An online survey was done to evaluate the various curricular components of MD pharmacology curriculum being used in India. A total of 393 respondents including faculty, MD students, and other stakeholders completed the survey. The survey was developed using SurveyMonkey platform and link to survey was E-mailed to stakeholders. The results were expressed as percentages. Results: There was a balanced representation of respondents from various designations, teaching experience, regions, and age groups. Most of the respondents (83%) were aware of the MD pharmacology curriculum. However, they reported that it is more inclined to knowledge domain. About half of respondents (53%) said that animal experiments are being used. The most common teaching methods mentioned are seminars (98.5%), journal clubs (95%), and practical exercises by postgraduates (73%), but there is less use of newer methods (25%) in theory and less of clinical pharmacology exercise (39%) in practical classes. The log books are maintained but not assessed regularly. Internal assessment is sparingly used. Conclusion: The MD pharmacology curriculum needs to be made uniform at the national level and updated to include the newer methods in teaching-learning and assessment. There should be sharing of newer methods at a common platform implemented at the national level. PMID:28031602

  12. An unusual dimeric structure and assembly for TLR4 regulator RP105-MD-1

    SciTech Connect

    Yoon, Sung-il; Hong, Minsun; Wilson, Ian A

    2011-11-16

    RP105-MD-1 modulates the TLR4-MD-2-mediated, innate immune response against bacterial lipopolysaccharide (LPS). The crystal structure of the bovine 1:1 RP105-MD-1 complex bound to a putative endogenous lipid at 2.9 Å resolution shares a similar overall architecture to its homolog TLR4-MD-2 but assembles into an unusual 2:2 homodimer that differs from any other known TLR-ligand assembly. The homodimer is assembled in a head-to-head orientation that juxtaposes the N-terminal leucine-rich repeats (LRRs) of the two RP105 chains, rather than the usual tail-to-tail configuration of C-terminal LRRs in ligand-activated TLR dimers, such as TLR1-TRL2, TLR2-TLR6, TLR3-TLR3 and TLR4-TLR4. Another unusual interaction is mediated by an RP105-specific asparagine-linked glycan, which wedges MD-1 into the co-receptor binding concavity on RP105. This unique mode of assembly represents a new paradigm for TLR complexes and suggests a molecular mechanism for regulating LPS responses.

  13. PuReMD-GPU: A reactive molecular dynamics simulation package for GPUs

    SciTech Connect

    Kylasa, S.B.; Aktulga, H.M.; Grama, A.Y.

    2014-09-01

    We present an efficient and highly accurate GP-GPU implementation of our community code, PuReMD, for reactive molecular dynamics simulations using the ReaxFF force field. PuReMD and its incorporation into LAMMPS (Reax/C) is used by a large number of research groups worldwide for simulating diverse systems ranging from biomembranes to explosives (RDX) at atomistic level of detail. The sub-femtosecond time-steps associated with ReaxFF strongly motivate significant improvements to per-timestep simulation time through effective use of GPUs. This paper presents, in detail, the design and implementation of PuReMD-GPU, which enables ReaxFF simulations on GPUs, as well as various performance optimization techniques we developed to obtain high performance on state-of-the-art hardware. Comprehensive experiments on model systems (bulk water and amorphous silica) are presented to quantify the performance improvements achieved by PuReMD-GPU and to verify its accuracy. In particular, our experiments show up to 16× improvement in runtime compared to our highly optimized CPU-only single-core ReaxFF implementation. PuReMD-GPU is a unique production code, and is currently available on request from the authors.

  14. TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS

    PubMed Central

    Wang, Ying; Su, Lijing; Morin, Matthew D.; Jones, Brian T.; Whitby, Landon R.; Surakattula, Murali M. R. P.; Huang, Hua; Shi, Hexin; Choi, Jin Huk; Wang, Kuan-wen; Moresco, Eva Marie Y.; Berger, Michael; Zhan, Xiaoming; Zhang, Hong; Boger, Dale L.; Beutler, Bruce

    2016-01-01

    Structurally disparate molecules reportedly engage and activate Toll-like receptor (TLR) 4 and other TLRs, yet the interactions that mediate binding and activation by dissimilar ligands remain unknown. We describe Neoseptins, chemically synthesized peptidomimetics that bear no structural similarity to the established TLR4 ligand, lipopolysaccharide (LPS), but productively engage the mouse TLR4 (mTLR4)/myeloid differentiation factor 2 (MD-2) complex. Neoseptin-3 activates mTLR4/MD-2 independently of CD14 and triggers canonical myeloid differentiation primary response gene 88 (MyD88)- and Toll-interleukin 1 receptor (TIR) domain-containing adaptor inducing IFN-beta (TRIF)-dependent signaling. The crystal structure mTLR4/MD-2/Neoseptin-3 at 2.57-Å resolution reveals that Neoseptin-3 binds as an asymmetrical dimer within the hydrophobic pocket of MD-2, inducing an active receptor complex similar to that induced by lipid A. However, Neoseptin-3 and lipid A form dissimilar molecular contacts to achieve receptor activation; hence strong TLR4/MD-2 agonists need not mimic LPS. PMID:26831104

  15. TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS.

    PubMed

    Wang, Ying; Su, Lijing; Morin, Matthew D; Jones, Brian T; Whitby, Landon R; Surakattula, Murali M R P; Huang, Hua; Shi, Hexin; Choi, Jin Huk; Wang, Kuan-wen; Moresco, Eva Marie Y; Berger, Michael; Zhan, Xiaoming; Zhang, Hong; Boger, Dale L; Beutler, Bruce

    2016-02-16

    Structurally disparate molecules reportedly engage and activate Toll-like receptor (TLR) 4 and other TLRs, yet the interactions that mediate binding and activation by dissimilar ligands remain unknown. We describe Neoseptins, chemically synthesized peptidomimetics that bear no structural similarity to the established TLR4 ligand, lipopolysaccharide (LPS), but productively engage the mouse TLR4 (mTLR4)/myeloid differentiation factor 2 (MD-2) complex. Neoseptin-3 activates mTLR4/MD-2 independently of CD14 and triggers canonical myeloid differentiation primary response gene 88 (MyD88)- and Toll-interleukin 1 receptor (TIR) domain-containing adaptor inducing IFN-beta (TRIF)-dependent signaling. The crystal structure mTLR4/MD-2/Neoseptin-3 at 2.57-Å resolution reveals that Neoseptin-3 binds as an asymmetrical dimer within the hydrophobic pocket of MD-2, inducing an active receptor complex similar to that induced by lipid A. However, Neoseptin-3 and lipid A form dissimilar molecular contacts to achieve receptor activation; hence strong TLR4/MD-2 agonists need not mimic LPS.

  16. STAT1 regulates MD-2 expression in monocytes of sepsis via miR-30a.

    PubMed

    Wang, Yanhong; Li, Tiehua; Wu, Benquan; Liu, Hui; Luo, Jinmei; Feng, Dingyun; Shi, Yunfeng

    2014-12-01

    Sepsis is a major cause of morbidity and mortality in critically ill patients. MD-2 is a 25-kDa lipopolysaccharide (LPS)-binding protein that forms a heterodimer with TLR42, but its regulation in sepsis is not clear. This study aims to investigate the molecular mechanism of regulation of MD-2. Inflammation cytokines in monocytes were analyzed by real-time RT-PCR and ELISA, and it was found that IL-10 was elevated significantly in the monocytes with LPS treatment. And then, when the cells were treated with IL-10, STAT1 was activated in the monocytes using Western blotting. It was also found that STAT1 could enhance MD-2 expression on transcriptional and posttranscriptional levels. Finally, miR-30a was predicted to the molecule that may regulate STAT1 expression. It was verified that STAT1 was a new target gene of miR-30a. miR-30a could inhibit IL-10-induced cytokine release by targeting STAT1-MD-2 in monocytes. In conclusion, this study for the first time demonstrated that miR-30a inhibits MD-2 expression by targeting of STAT1 in human monocytes.

  17. Degradation of the Adhesive Properties of MD-944 Diode Tape by Simulated Low Earth Orbit Environmental Factors

    NASA Technical Reports Server (NTRS)

    Albyn, K.; Finckenor, M.

    2006-01-01

    The International Space Station (ISS) solar arrays utilize MD-944 diode tape with silicone pressure-sensitive adhesive to protect the underlying diodes and also provide a high-emittance surface. On-orbit, the silicone adhesive will be exposed and ultimately convert to a glass-like silicate due to atomic oxygen (AO). The current operational plan is to retract ISS solar array P6 and leave it stored under load for a long duration (6 mo or more). The exposed silicone adhesive must not cause the solar array to stick to itself or cause the solar array to fail during redeployment. The Environmental Effects Branch at Marshall Space Flight Center, under direction from the ISS Program Office Environments Team, performed simulated space environment exposures with 5-eV AO, near ultraviolet radiation and ionizing radiation. The exposed diode tape samples were put under preload and then the resulting blocking force was measured using a tensile test machine. Test results indicate that high-energy AO, ultraviolet radiation, and electron ionizing radiation exposure all reduce the blocking force for a silicone-to-silicone bond. AO exposure produces the most significant reduction in blocking force

  18. Understanding self-assembly of charged-neutral block copolymer (BCP) and surfactant complexes using molecular dynamics (MD) simulation

    NASA Astrophysics Data System (ADS)

    Goswami, Monojoy; Sumpter, Bobby; Kilbey, Michael

    Here we report the formation of phase separated BCP-surfactant complexes resulting from the electrostatic self-assembly of charge-neutral block copolymers with oppositely charged surfactants. Complexation behaviors of oppositely charged polyelectrolytes has gained considerable attention in the field of soft condensed matter physics due to their potential application as functional nanomaterials for batteries, wastewater treatment and drug delivery systems. Numerous experiments have examined the self-assembled structures resulting from complexation of charge-neutral BCP and surfactants, however, there is a lack of comprehensive understanding at the fundamental level. To help bridge this gap, we use, MD simulations to study self-assembly and dynamics of the BCP-surfactant complex at the molecular level. Our results show an overcharging effect in BCPs with hydrophobic neutral blocks and a formation of core-shell colloidal structure. Hydrophilic neutral blocks, on the other hand, show stable, hairy colloidal structures with neutral blocks forming a loosely-bound, fuzzy outer layer. Our results qualitatively agree with previous SANS and SAXS experiments. This work was supported by the U.S. Department of Energy (DOE), Office of Basic Energy Sciences, Materials Science and Engineering Division.

  19. 75 FR 10293 - Office of Biotechnology Activities; Office of Science Policy; Office of the Director; Notice of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-05

    ... Biotechnology Activities; Office of Science Policy; Office of the Director; Notice of a Meeting of the NIH Blue..., Office of Biotechnology Activities, Office of Science Policy, Office of the Director, National Institutes... lewallenl@od.nih.gov . Dated: March 1, 2010. Amy P. Patterson, Director, Office of Biotechnology...

  20. 49 CFR 800.25 - Delegation to the Directors of Office of Aviation Safety, Office of Railroad Safety, Office of...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 7 2013-10-01 2013-10-01 false Delegation to the Directors of Office of Aviation... Office of Aviation Safety, Office of Railroad Safety, Office of Highway Safety, Office of Marine Safety... Offices of Aviation, Railroad, Highway, Marine, and Pipeline and Hazardous Materials Safety, the...

  1. 49 CFR 800.25 - Delegation to the Directors of Office of Aviation Safety, Office of Railroad Safety, Office of...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 7 2012-10-01 2012-10-01 false Delegation to the Directors of Office of Aviation... Office of Aviation Safety, Office of Railroad Safety, Office of Highway Safety, Office of Marine Safety... Offices of Aviation, Railroad, Highway, Marine, and Pipeline and Hazardous Materials Safety, the...

  2. 49 CFR 800.25 - Delegation to the Directors of Office of Aviation Safety, Office of Railroad Safety, Office of...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 7 2014-10-01 2014-10-01 false Delegation to the Directors of Office of Aviation... Office of Aviation Safety, Office of Railroad Safety, Office of Highway Safety, Office of Marine Safety... Offices of Aviation, Railroad, Highway, Marine, and Pipeline and Hazardous Materials Safety, the...

  3. 49 CFR 800.25 - Delegation to the Directors of Office of Aviation Safety, Office of Railroad Safety, Office of...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 7 2011-10-01 2011-10-01 false Delegation to the Directors of Office of Aviation... Office of Aviation Safety, Office of Railroad Safety, Office of Highway Safety, Office of Marine Safety... Offices of Aviation, Railroad, Highway, Marine, and Pipeline and Hazardous Materials Safety, the...

  4. Prediction of Effective Officer Performance

    DTIC Science & Technology

    1959-06-01

    miniature. Sinc" field observation and logical analysis of officer MOB schedules had led to ,the aypothesis that psychological demands differ among...could adequately reflect the differential psychological demands from job to job. The efficiency reports of 10,000 officers were analyzed and the results...showed no evidence of differential psychological demands among combat, technical, and administrative officer assignments or among any other group

  5. FATSLiM: a fast and robust software to analyze MD simulations of membranes.

    PubMed

    Buchoux, Sébastien

    2017-01-01

    When studying biological membranes, Molecular Dynamics (MD) simulations reveal to be quite complementary to experimental techniques. Because the simulated systems keep increasing both in size and complexity, the analysis of MD trajectories need to be computationally efficient while being robust enough to perform analysis on membranes that may be curved or deformed due to their size and/or protein-lipid interactions. This work presents a new software named FATSLiM ('Fast Analysis Toolbox for Simulations of Lipid Membranes') that can extract physical properties from MD simulations of membranes (with or without interacting proteins). Because it relies on the calculation of local normals, FATSLiM does not depend of the bilayer morphology and thus can handle with the same accuracy vesicles for instance. Thanks to an efficiency-driven development, it is also fast and consumes a rather low amount of memory.

  6. Integrated Budget Office Toolbox

    NASA Technical Reports Server (NTRS)

    Rushing, Douglas A.; Blakeley, Chris; Chapman, Gerry; Robertson, Bill; Horton, Allison; Besser, Thomas; McCarthy, Debbie

    2010-01-01

    The Integrated Budget Office Toolbox (IBOT) combines budgeting, resource allocation, organizational funding, and reporting features in an automated, integrated tool that provides data from a single source for Johnson Space Center (JSC) personnel. Using a common interface, concurrent users can utilize the data without compromising its integrity. IBOT tracks planning changes and updates throughout the year using both phasing and POP-related (program-operating-plan-related) budget information for the current year, and up to six years out. Separating lump-sum funds received from HQ (Headquarters) into separate labor, travel, procurement, Center G&A (general & administrative), and servicepool categories, IBOT creates a script that significantly reduces manual input time. IBOT also manages the movement of travel and procurement funds down to the organizational level and, using its integrated funds management feature, helps better track funding at lower levels. Third-party software is used to create integrated reports in IBOT that can be generated for plans, actuals, funds received, and other combinations of data that are currently maintained in the centralized format. Based on Microsoft SQL, IBOT incorporates generic budget processes, is transportable, and is economical to deploy and support.

  7. Women geoscientists select officers

    NASA Astrophysics Data System (ADS)

    1984-04-01

    The Association for Women Geoscientists Foundation has selected a board of directors to spearhead the development of educational and community programs geared to the earth sciences. The foundation, established in 1983, plans to provide grants to women studying the geosciences, to support a geology field program in cooperation with the Girl Scouts of America, and to undertake development of career guidance programs targeting junior and senior high school girls.Lois K. Ongley, an independent geologist in Houston, Tex., is president. Gwenn M. Jensen, an exploration geologist for Cities Service Oil & Gas Corp. in Denver, Colo., is vice president. Constance A. Sancetta, associate research scientist at the Lamont-Doherty Geological Observatory, is secretary. Susan J. Mara, resource analyst for the Pacific Gas & Electric Co. in San Francisco, Calif., is treasurer. The board of directors' three advisors are Maria Luisa Crawford, department chairman and professor at the geology department, Bryn Mawr College, Bryn Mawr, Pa.; Judith B. Mooney, project manager in the office of nuclear waste isolation of Battelle Memorial Institute in Columbus, Ohio; and A.F. Spilhaus, Jr., AGU executive director and Eos editor-in-chief.

  8. Business Office Clerical/Business Office Services. Teacher's Guide.

    ERIC Educational Resources Information Center

    Patton, Jan

    This curriculum guide for business office clerical/business office services provides instructional materials for Texas business course instructors. The following sections are included: (1) introduction; (2) keyboarding--skills, proofreading, and word processing; (3) filing--alphabetic, numeric, and electronic; (4) operating office…

  9. Office Space: How Will Technology Affect the Education Office Environment?

    ERIC Educational Resources Information Center

    Day, C. William

    2009-01-01

    The office environment 10 years from now will be different from the one today. More office personnel will be organized around processes rather than functions. More work activities will be done by teams rather than individuals, and those teams will change over time, as will the nature of the work projects and the people who constitute the team. The…

  10. Simulating picosecond X-ray diffraction from crystals using FFT methods on MD output

    SciTech Connect

    Kimminau, Giles; Nagler, Bob; Higginbotham, Andrew; Murphy, William; Wark, Justin; Park, Nigel; Hawreliak, James; Kalantar, Dan; Lorenzana, Hector; Remington, Bruce

    2007-12-12

    Multi-million atom non-equilibrium molecular dynamics (MD) simulations give significant insight into the transient processes that occur under shock compression. Picosecond X-ray diffraction enables the probing of materials on a timescale fast enough to test such effects. In order to simulate diffraction patterns, Fourier methods are required to gain a picture of reciprocal lattice space. We present here results of fast Fourier transforms of atomic coordinates of shocked crystals simulated by MD, and comment on the computing power required as a function of problem size. The relationship between reciprocal space and particular experimental geometries is discussed.

  11. Computation of shear viscosity of colloidal suspensions by SRD-MD.

    PubMed

    Laganapan, A M K; Videcoq, A; Bienia, M; Ala-Nissila, T; Bochicchio, D; Ferrando, R

    2015-04-14

    The behaviour of sheared colloidal suspensions with full hydrodynamic interactions (HIs) is numerically studied. To this end, we use the hybrid stochastic rotation dynamics-molecular dynamics (SRD-MD) method. The shear viscosity of colloidal suspensions is computed for different volume fractions, both for dilute and concentrated cases. We verify that HIs help in the collisions and the streaming of colloidal particles, thereby increasing the overall shear viscosity of the suspension. Our results show a good agreement with known experimental, theoretical, and numerical studies. This work demonstrates the ability of SRD-MD to successfully simulate transport coefficients that require correct modelling of HIs.

  12. Computation of shear viscosity of colloidal suspensions by SRD-MD

    SciTech Connect

    Laganapan, A. M. K.; Videcoq, A. Bienia, M.; Ala-Nissila, T.; Bochicchio, D.; Ferrando, R.

    2015-04-14

    The behaviour of sheared colloidal suspensions with full hydrodynamic interactions (HIs) is numerically studied. To this end, we use the hybrid stochastic rotation dynamics-molecular dynamics (SRD-MD) method. The shear viscosity of colloidal suspensions is computed for different volume fractions, both for dilute and concentrated cases. We verify that HIs help in the collisions and the streaming of colloidal particles, thereby increasing the overall shear viscosity of the suspension. Our results show a good agreement with known experimental, theoretical, and numerical studies. This work demonstrates the ability of SRD-MD to successfully simulate transport coefficients that require correct modelling of HIs.

  13. MD-2 Residues Tyrosine 42, Arginine 69, Aspartic Acid 122, and Leucine 125 Provide Species Specificity for Lipid IVA*

    PubMed Central

    Meng, Jianmin; Drolet, Joshua R.; Monks, Brian G.; Golenbock, Douglas T.

    2010-01-01

    Lipopolysaccharide (LPS) activates the innate immune response through the Toll-like receptor 4 (TLR4)·MD-2 complex. A synthetic lipid A precursor, lipid IVA, induces an innate immune response in mice but not in humans. Both TLR4 and MD-2 are required for the agonist activity of lipid IVA in mice, with TLR4 interacting through specific surface charges at the dimerization interface. In this study, we used site-directed mutagenesis to identify the MD-2 residues that determine lipid IVA species specificity. A single mutation of murine MD-2 at the hydrophobic pocket entrance, E122K, substantially reduced the response to lipid IVA. Combining the murine MD-2 E122K with the murine TLR4 K367E/S386K/R434Q mutations completely abolished the response to lipid IVA, effectively converting the murine cellular response to a human-like response. In human cells, however, simultaneous mutations of K122E, K125L, Y41F, and R69G on human MD-2 were required to promote a response to lipid IVA. Combining the human MD-2 quadruple mutations with the human TLR4 E369K/Q436R mutations completely converted the human MD-2/human TLR4 receptor to a murine-like receptor. Because MD-2 residues 122 and 125 reside at the dimerization interface near the pocket entrance, surface charge differences here directly affect receptor dimerization. In comparison, residues 42 and 69 reside at the MD-2/TLR4 interaction surface opposite the dimerization interface. Surface charge differences there likely affect the binding angle and/or rigidity between MD-2 and TLR4, exerting an indirect influence on receptor dimerization and activation. Thus, surface charge differences at the two MD-2/TLR4 interfaces determine the species-specific activation of lipid IVA. PMID:20592019

  14. 75 FR 69091 - Office of the Director, Office of Biotechnology Activities; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-10

    ... HUMAN SERVICES National Institutes of Health Office of the Director, Office of Biotechnology Activities.... Agenda: The Office of Biotechnology Activities (OBA), NIH Recombinant DNA Advisory Committee and the... George, Program Assistant, Office of Science Policy, Office of Biotechnology Activities,...

  15. The MdTFL1 gene of apple (Malus x domestica Borkh.) reduces vegetative growth and generation time.

    PubMed

    Flachowsky, Henryk; Szankowski, Iris; Waidmann, Sascha; Peil, Andreas; Tränkner, Conny; Hanke, Magda-Viola

    2012-10-01

    TFL1 is known as a floral repressor in Arabidopsis thaliana (L.) Heynh. In apple there are two TFL1 homologs, MdTFL1-1 and MdTFL1-2. The MdTFL1-1 gene was silenced in transgenic clones expressing a hairpin gene construct of a 323 bp fragment of MdTFL1-1. The hairpin gene construct was transferred to three different apple genotypes. Of 22 transgenic clones, 21 showed a significant reduction in MdTFL1-1 mRNA expression. Precocious flowering was obtained for 20 clones, which flowered already during in vitro cultivation. Nineteen clones could successfully be transferred to the greenhouse where 18 of them flowered within a few weeks followed by the death or at least a strongly inhibited vegetative growth of the plant. Most of the transgenic flowers developed abnormally. Results obtained on greenhouse-grown plants of the transgenic clones and transgenic seedlings clearly demonstrated the major role of MdTFL1 genes in maintaining the vegetative growth as prerequisite for a perennial lifecycle. It was shown that MdTFL1 dsRNAi promotes a life history similar to annual plants. Preliminary results obtained from grafting experiments with non-transgenic scions grafted onto MdTFL1 dsRNAi transgenic rootstocks indicated that the flower-inducing signal obtained after silencing of MdTFL1 genes seems not to be graft-transmissible.

  16. Athena Community Office

    NASA Astrophysics Data System (ADS)

    Martínez-Núnez, S.; Barcons, X.; Barret, D.; Bozzo, E.; Carrera, F. J.; Ceballos, M. T.; Gómez, S.; Monterde, M. P.; Rau, A.

    2017-03-01

    The Athena Community Office (ACO) has been established by ESA's Athena Science Study Team (ASST) in order to obtain support in performing its tasks assigned by ESA, and most specially in the ASST role as "focal point for the interests of the broad scientific community". The ACO is led by the Instituto de Física de Cantabria (CSIC-UC), and its activities are funded by CSIC and UC. Further ACO contributors are the University of Geneva, MPE and IRAP. In this poster, we present ACO to the Spanish Astronomical Community, informing about its main responsibilities, which are: assist the ASST in organising and collecting support from the Athena Working Groups and Topical Panels; organise and maintain the documentation generated by the Athena Working Groups and Topical Panels; manage the Working Group and Topical Panel membership lists; assist the ASST in promoting Athena science capabilities in the research world, through conferences and workshops; keep a record of all papers and presentations related to Athena; support the production of ASST documents; produce and distribute regularly an Athena Newsletter, informing the community about all mission and science developments; create and maintain the Athena Community web portal; maintain an active communication activity; promote, organise and support Athena science-related public outreach, in coordination with ESA and other agencies involved when appropriate; and, design, produce materials and provide pointers to available materials produced by other parties. In summary, ACO is meant to become a focal point to facilitate the scientific exchange between the Athena activities and the scientific community at large, and to disseminate the Athena science objectives to the general public.

  17. The properly negotiated office lease.

    PubMed

    Josselson, B H

    1996-10-01

    The signing of an office lease is not a task any dentist should undertake alone. This article reviews several points that should be addressed by the typical office lease. Failing to incorporate some of these provisions could be the difference between success and failure of a dental practice.

  18. The New Planned Giving Officer.

    ERIC Educational Resources Information Center

    Jordan, Ronald R.; Quynn, Katelyn L.

    1994-01-01

    A planned giving officer is seen as an asset to college/university development for technical expertise, credibility, and connections. Attorneys, certified public accountants, bank trust officers, financial planners, investment advisers, life insurance agents, and real estate brokers may be qualified but probably also need training. (MSE)

  19. Arkansas' Office Procedures Curriculum Guide.

    ERIC Educational Resources Information Center

    Clayton, Dean

    This curriculum guide provides teachers of office procedures classes with unit lesson plans and information about resource materials that can be examined, selected, and integrated into the instructional program. Contents are mainly established for the following two types of secondary-level programs: cooperative office education and intensive…

  20. Safety in the Automated Office.

    ERIC Educational Resources Information Center

    Graves, Pat R.; Greathouse, Lillian R.

    1990-01-01

    Office automation has introduced new hazards to the workplace: electrical hazards related to computer wiring, musculoskeletal problems resulting from use of computer terminals and design of work stations, and environmental concerns related to ventilation, noise levels, and office machine chemicals. (SK)

  1. Richland Operations Office technology summary

    SciTech Connect

    Not Available

    1994-05-01

    This document has been prepared by the Department of Energy`s Environmental Management Office of Technology Development to highlight its research, development, demonstration, testing, and evaluation activities funded through the Richland Operations Office. Technologies and processes described have the potential to enhance cleanup and waste management efforts.

  2. Office Duplication Practices Curriculum Guide.

    ERIC Educational Resources Information Center

    East Texas State Univ., Commerce. Occupational Curriculum Lab.

    As one of a series of curriculum guides for office education programs in Texas, this guide contains 24 units of instruction in office duplication practices. Each of the units contains a unit outline that lists unit objective, specific objectives, teacher and student activities, estimated completion time, re-teach activities, and resources; and a…

  3. Career Indications Among Junior Officers.

    ERIC Educational Resources Information Center

    Shenk, Faye

    A study of officer input from the principal Air Force commissioning programs was undertaken to determine the predictability of an Air Force officer's career decision and to evaluate relationships between career intent and various demographic, environmental, and attitudinal factors. This report describes the study and provides a preliminary…

  4. Office for Human Research Protections

    MedlinePlus

    ... A A A Print Share Office for Human Research Protections The Office for Human Research Protections (OHRP) provides leadership in the protection of ... welfare, and wellbeing of human subjects involved in research conducted or supported by the U.S. Department of ...

  5. 33 CFR 110.70 - Chesapeake and Delaware Canal, easterly of Courthouse Point, Md.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Chesapeake and Delaware Canal, easterly of Courthouse Point, Md. 110.70 Section 110.70 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.70 Chesapeake and Delaware Canal, easterly of...

  6. 75 FR 18778 - Safety Zone; Ocean City Air Show 2010, Atlantic Ocean, Ocean City, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-13

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Ocean City Air Show 2010, Atlantic Ocean, Ocean City, MD AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking. SUMMARY: The Coast Guard proposes establishing a temporary safety zone on the Atlantic Ocean in the vicinity of Ocean City,...

  7. Novel plasmid conferring kanamycin and tetracycline resistance in turkey-derived Campylobacter jejuni strain 11601MD

    Technology Transfer Automated Retrieval System (TEKTRAN)

    In Campylobacter spp., resistance to the antibiotics kanamycin and tetracycline is frequently associated with plasmid-borne genes. However, relatively few plasmids of Campylobacter jejuni have been fully characterized to date. A novel plasmid (p11601MD; 44,095 bp.) harboring tet(O) was identified in...

  8. Vienna-PTM web server: a toolkit for MD simulations of protein post-translational modifications

    PubMed Central

    Margreitter, Christian; Petrov, Drazen; Zagrovic, Bojan

    2013-01-01

    Post-translational modifications (PTMs) play a key role in numerous cellular processes by directly affecting structure, dynamics and interaction networks of target proteins. Despite their importance, our understanding of protein PTMs at the atomistic level is still largely incomplete. Molecular dynamics (MD) simulations, which provide high-resolution insight into biomolecular function and underlying mechanisms, are in principle ideally suited to tackle this problem. However, because of the challenges associated with the development of novel MD parameters and a general lack of suitable computational tools for incorporating PTMs in target protein structures, MD simulations of post-translationally modified proteins have historically lagged significantly behind the studies of unmodified proteins. Here, we present Vienna-PTM web server (http://vienna-ptm.univie.ac.at), a platform for automated introduction of PTMs of choice to protein 3D structures (PDB files) in a user-friendly visual environment. With 256 different enzymatic and non-enzymatic PTMs available, the server performs geometrically realistic introduction of modifications at sites of interests, as well as subsequent energy minimization. Finally, the server makes available force field parameters and input files needed to run MD simulations of modified proteins within the framework of the widely used GROMOS 54A7 and 45A3 force fields and GROMACS simulation package. PMID:23703210

  9. Interdisciplinary Learning in Pharmacology: Analysis of M.D. and P.A. Student Performance.

    ERIC Educational Resources Information Center

    Andrus, Peter L.; And Others

    1981-01-01

    An analysis of M.D. and physician's assistant (P.A.) student comparative performances at Baylor College of Medicine is presented. The analysis was seen as being appropriate in view of the P.A.'s increasing involvement with the implementation and monitoring of therapeutic programs. (Author/MLW)

  10. 33 CFR 165.507 - Security Zone; Chesapeake Bay, between Sandy Point and Kent Island, MD.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Security Zone; Chesapeake Bay... Guard District § 165.507 Security Zone; Chesapeake Bay, between Sandy Point and Kent Island, MD. (a... security zone: All waters of the Chesapeake Bay, from the surface to the bottom, within 250 yards north...

  11. Comments on ""Lake Woebegone," Twenty Years Later" by J. J. Cannell, MD

    ERIC Educational Resources Information Center

    McRae, D. J.

    2006-01-01

    This article presents the author's comments on ""Lake Woebegone," Twenty Years Later" by J. J. Cannell, MD. J. J. Cannell's article on the so-called "Lake Woebegone" effect for K-12 educational testing systems is mostly an historical account of technical issues and policy considerations that led in part to development…

  12. 76 FR 70346 - Drawbridge Operation Regulation; Isle of Wight (Sinepuxent) Bay, Ocean City, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-14

    ... changing the regulation governing the operation of the US 50 Bridge over Isle of Wight (Sinepuxent) Bay, mile 0.5, at Ocean City, MD. This rule will add dates that the bridge is allowed to remain in the... show. DATES: This rule is effective December 14, 2011. ADDRESSES: Comments and related...

  13. 33 CFR 165.513 - Safety Zone; Magothy River, Sillery Bay, MD.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Safety Zone; Magothy River... Safety Zone; Magothy River, Sillery Bay, MD. (a) Regulated area. The following area is a safety zone: All waters of the Magothy River, in Sillery Bay, contained within lines connecting the following...

  14. 33 CFR 165.513 - Safety Zone; Magothy River, Sillery Bay, MD.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Safety Zone; Magothy River... Safety Zone; Magothy River, Sillery Bay, MD. (a) Regulated area. The following area is a safety zone: All waters of the Magothy River, in Sillery Bay, contained within lines connecting the following...

  15. 33 CFR 165.513 - Safety Zone; Magothy River, Sillery Bay, MD.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Safety Zone; Magothy River... Safety Zone; Magothy River, Sillery Bay, MD. (a) Regulated area. The following area is a safety zone: All waters of the Magothy River, in Sillery Bay, contained within lines connecting the following...

  16. 75 FR 80742 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-23

    ... MD-90-30 airplanes. This proposed AD would require repetitive inspections for cracking of the left.... This proposed AD was prompted by a report of a crack found in the upper skin panel at the aft inboard corner of a right horizontal stabilizer. We are proposing this AD to detect and correct cracks in...

  17. 76 FR 77580 - Maryland Disaster #MD-00020 Declaration of Economic Injury

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-13

    ... ADMINISTRATION Maryland Disaster MD-00020 Declaration of Economic Injury AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Economic Injury Disaster Loan (EIDL) declaration...'s EIDL declaration, applications for economic injury disaster loans may be filed at the...

  18. PHYSICAL PROPERTIES OF NEAR-EARTH ASTEROID 2011 MD

    SciTech Connect

    Mommert, M.; Trilling, D. E.; Farnocchia, D.; Chesley, S. R.; Chodas, P. W.; Hora, J. L.; Smith, H. A.; Fazio, G. G.; Mueller, M.; Harris, A. W.

    2014-07-01

    We report on observations of near-Earth asteroid 2011 MD with the Spitzer Space Telescope. We have spent 19.9 hr of observing time with channel 2 (4.5 μm) of the Infrared Array Camera and detected the target within the 2σ positional uncertainty ellipse. Using an asteroid thermophysical model and a model of nongravitational forces acting upon the object, we constrain the physical properties of 2011 MD, based on the measured flux density and available astrometry data. We estimate 2011 MD to be (6{sub −2}{sup +4}) m in diameter with a geometric albedo of 0.3{sub −0.2}{sup +0.4} (uncertainties are 1σ). We find the asteroid's most probable bulk density to be (1.1{sub −0.5}{sup +0.7}) g cm{sup –3}, which implies a total mass of (50-350) t and a macroporosity of ≥65%, assuming a material bulk density typical of non-primitive meteorite materials. A high degree of macroporosity suggests that 2011 MD is a rubble-pile asteroid, the rotation of which is more likely to be retrograde than prograde.

  19. 76 FR 65118 - Drawbridge Operation Regulation; Bear Creek, Sparrows Point, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-20

    ... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Bear Creek, Sparrows... Avenue) highway toll drawbridge across Bear Creek, mile 1.5, Sparrows Point, MD was replaced with a fixed... Bear Creek, mile 1.5 was removed and replaced with a fixed bridge in 1998. Prior to 1998, a...

  20. 76 FR 23185 - Drawbridge Operation Regulation; Isle of Wight (Sinepuxent) Bay, Ocean City, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-26

    ... (Sinepuxent) Bay, Ocean City, MD AGENCY: Coast Guard, DHS. ACTION: Final rule. SUMMARY: The Coast Guard is changing the regulation governing the operation of the US 50 Bridge over Isle of Wight (Sinepuxent) Bay... location from Isle of Wight Bay to Isle of Wight (Sinepuxent) Bay. This change is necessary because...

  1. 75 FR 18056 - Safety Zone; Fireworks Display, Patuxent River, Solomons Island Harbor, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-09

    ... Island Harbor, MD AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary safety zone upon specified waters of Solomons Island Harbor, a tributary of the... fireworks display launched from discharge barge located in Solomons Island, Calvert County, Maryland....

  2. 78 FR 12091 - Brian Earl Cressman, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-21

    ... record, revoking the registrant's registration would not be appropriate. Morall v. DEA, 412 F.3d 165, 174... and therefore recommended that his DEA Certificate of Registration, BC4785614, be revoked. See... Registration BC4785614, issued to Brian Earl Cressman, M.D., be, and it hereby is, revoked. I further...

  3. 76 FR 71369 - Robert G. Crummie, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-17

    ....100(b) and 0.104, I order that DEA Certificate of Registration, BC2964965, issued to Robert G. Crummie.... Crummie, M.D., to renew or modify his registration, be, and it hereby is, denied. This Order is effective.... 551 et seq., to determine whether Respondent's Certificate of Registration with the Drug...

  4. 76 FR 20034 - Calvin Ramsey, M.D.; Revocation of Registration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-11

    .... Recore, 446 F.3d 324, 330-31 (2d Cir. 2006). Under DEA's longstanding interpretation of the CSA... Enforcement Administration Calvin Ramsey, M.D.; Revocation of Registration On December 18, 2009, the Deputy... the revocation of Respondent's DEA Certificate of Registration, AR7086689, as a practitioner, and...

  5. 76 FR 17672 - Alfred E. Boyce, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-30

    ....100(b) and 0.104, I order that DEA Certificate of Registration, FB0003943, issued to Alfred E. Boyce..., M.D., to renew or modify his registration, be, and it hereby is, denied. This Order is effective... May 13, 2010, proposing to revoke the DEA Certificate of Registration (COR), Number FB0003943,...

  6. 76 FR 71370 - Silviu Ziscovici, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-17

    ....100(b) and 0.104, I order that DEA Certificate of Registration, BZ4692756, issued to Silviu Ziscovici... Ziscovici, M.D., to renew or modify his registration, be, and it hereby is, denied. This Order is effective immediately.\\1\\ \\1\\ For the same reasons that led me to order that Respondent's registration be...

  7. 77 FR 68149 - Karen Paul Holley, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-15

    ... Certificate of Registration be revoked and that any pending application to renew or modify her registration be....100(b), I order that DEA Certificate of Registration Number BH8988339, issued to Karen P. Holley, M.D...., to renew or modify her registration, be, and it hereby is, denied. This Order is effective...

  8. 76 FR 53961 - Harold Edward Smith, M.D.; Revocation Of Registration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-30

    ... Enforcement Administration Harold Edward Smith, M.D.; Revocation Of Registration On April 17, 2009, the Deputy... proposed the revocation of Respondent's DEA Certificate of Registration, BS4681979, and the denial of any pending applications to renew or modify the registration, on the grounds that Respondent had...

  9. 75 FR 32866 - Special Local Regulations for Marine Events; Patuxent River, Solomons, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-10

    ... SECURITY Coast Guard 33 CFR Part 100 RIN 1625-AA08 Special Local Regulations for Marine Events; Patuxent... races, a marine event to be held on the waters of the Patuxent River, near Solomons, MD on October 3... waters during the event. This action is intended to temporarily restrict vessel traffic in a portion...

  10. 76 FR 35802 - Special Local Regulations for Marine Events; Patuxent River, Solomons, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-20

    .... USCG-2011-0266] RIN 1625-AA08 Special Local Regulations for Marine Events; Patuxent River, Solomons, MD... establish special local regulations during the ``Chesapeake Challenge'' power boat races, a marine event to... event. This action is intended to temporarily restrict vessel traffic in a portion of the Patuxent...

  11. 77 FR 25649 - Special Local Regulations for Marine Events; Patuxent River, Solomons, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-01

    ... SECURITY Coast Guard 33 CFR Part 100 RIN 1625-AA08 Special Local Regulations for Marine Events; Patuxent... races, a marine event to be held on the waters of the Patuxent River, near Solomons, MD on September 15... navigable waters during the event. This action is intended to temporarily restrict vessel ] traffic in...

  12. PERSONAL EXPOSURE TO PM2.5 MASS AND TRACE ELEMENTS IN BALTIMORE, MD, USA

    EPA Science Inventory

    In a recent study, EPA found significant relationships between PM2.5 mass measurements at a community site and personal exposure samples in a Towson, MD retirement facility. This manuscript builds upon these results by evaluating the exposure relationships with the elemental c...

  13. Owner, operator of Boonsboro, Md. industrial shop settle with EPA to resolve hazardous waste violations

    EPA Pesticide Factsheets

    (PHILADELPHIA - June 11, 2015) - In a consent agreement with the U.S. Environmental Protection Agency, the owner and operator of the Central Precision, Inc. sheet metal and machine shop in Boonsboro, Md. will pay a $100,000 penalty and take immediat

  14. A mathematic model that describes modes of MdSGHV transmission within house fly populations

    Technology Transfer Automated Retrieval System (TEKTRAN)

    In this paper it is proposed that one potential component by which the Musca domestica salivary gland hypertrophy virus (MdSGHV) infects individual flies is through cuticular damage. Breaks in the cuticle allow entry of the virus into the hemocoel causing the infection. Male flies typically have a h...

  15. 76 FR 54153 - Proposed Amendment of Class D and Class E Airspace; Baltimore, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-31

    ... Martin Non-Directional Beacon (NDB) has been decommissioned and new Standard Instrument Approach Procedures have been developed at Martin State Airport. This action would also update the geographic... surface airspace at Martin State Airport, Baltimore, MD. Airspace reconfiguration is necessary due to...

  16. 76 FR 72837 - Amendment of Class D and Class E Airspace; Baltimore, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-28

    ... D and Class E airspace at Baltimore, MD, as the Martin Non-Directional Beacon (NDB) has been decommissioned and new Standard Instrument Approach Procedures have been developed at Martin State Airport. This... Register a notice of proposed rulemaking (NPRM) to amend Class D and E airspace at Martin State...

  17. 77 FR 37068 - Muzaffer Aslan, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-20

    ...] [FR Doc No: 2012-15061] DEPARTMENT OF JUSTICE Drug Enforcement Administration Muzaffer Aslan, M.D..., issued an Order to Show Cause and Immediate Suspension of Registration to Muzaffer Aslan, M.D....C. 824, of the CSA. Calvin Ramsey, 76 FR 20034, 20036 (2011) (other citations omitted); Brenton...

  18. 77 FR 18862 - Zhiwei Lin, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-28

    ... Enforcement Administration Zhiwei Lin, M.D.; Decision and Order On September 19, 2011, Administrative Law Judge (ALJ) Timothy D. Wing issued the attached recommended decision (also ALJ). Therein, the ALJ found... 20034, 20036 (2011) (other citations omitted); Brenton D. Glisson, 72 FR 54296, 54297 n.2 (2007);...

  19. 75 FR 60665 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-01

    ... MD-90-30 airplanes. This proposed AD would require repetitive high frequency eddy current inspections... 17, 2010, describes procedures for doing repetitive high frequency eddy current (HFEC) inspections... this AD, do a high frequency eddy current (HFEC) inspection for cracking on the hinge bearing lugs...

  20. THE NATIONAL COASTAL ASSESSMENT SETAC ANNUAL MEETING, BALTIMORE, MD NOV 2001

    EPA Science Inventory

    To be presented at the 22nd Annual Meeting of the Society of Environmental Toxicology and Chemistry: Changing Environmental Awareness: Societal Concerns and Scientific Responses, 11-15 November 2001, Baltimore, MD. 1 p. (ERL,GB R859).

    The primary purpose of the Environmen...

  1. 75 FR 27430 - Special Local Regulations for Marine Events; Patapsco River, Northwest Harbor, Baltimore, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-17

    ...: The Coast Guard is establishing special local regulations during the ``Baltimore Dragon Boat Challenge... June 19, 2010, Baltimore Dragon Boat Club, Inc. will sponsor Dragon Boat Races in the Patapsco River, Northwest Harbor at Baltimore, MD. The event will consist of approximately 15 teams rowing Chinese...

  2. The draft genome of MD-2 pineapple using hybrid error correction of long reads

    PubMed Central

    Redwan, Raimi M.; Saidin, Akzam; Kumar, S. Vijay

    2016-01-01

    The introduction of the elite pineapple variety, MD-2, has caused a significant market shift in the pineapple industry. Better productivity, overall increased in fruit quality and taste, resilience to chilled storage and resistance to internal browning are among the key advantages of the MD-2 as compared with its previous predecessor, the Smooth Cayenne. Here, we present the genome sequence of the MD-2 pineapple (Ananas comosus (L.) Merr.) by using the hybrid sequencing technology from two highly reputable platforms, i.e. the PacBio long sequencing reads and the accurate Illumina short reads. Our draft genome achieved 99.6% genome coverage with 27,017 predicted protein-coding genes while 45.21% of the genome was identified as repetitive elements. Furthermore, differential expression of ripening RNASeq library of pineapple fruits revealed ethylene-related transcripts, believed to be involved in regulating the process of non-climacteric pineapple fruit ripening. The MD-2 pineapple draft genome serves as an example of how a complex heterozygous genome is amenable to whole genome sequencing by using a hybrid technology that is both economical and accurate. The genome will make genomic applications more feasible as a medium to understand complex biological processes specific to pineapple. PMID:27374615

  3. sTLR4/MD-2 complex inhibits colorectal cancer in vitro and in vivo by targeting LPS

    PubMed Central

    Meng, Jie; Wei, Liuhua; Wu, Chunlin; Zhang, Qiaoyun; Wei, Dong; Chen, Xiang; Wu, Hao; Chen, Xiaoli; Dai, Shengming

    2016-01-01

    Colorectal cancer (CRC) is aggressive and associated with TLR4-MD-2 signaling. Toll-like receptor 4 (TLR4) and myeloid differentiation protein 2 (MD-2) were highly expressed in human CRC. The soluble form of extracellular TLR4 domain (sTLR4) and MD-2 may have important roles in binding lipopolysaccharide (LPS). In this study, sTLR4 and MD-2 protein and prepared sTLR4/MD-2 complex were synthesized successfully to restrain LPS-TLR4/MD-2 activation by competing with cellular membrane TLR4 for binding LPS. The sTLR4/MD-2 complex can significantly attenuate LPS induced pro-inflammatory and migration cytokine production in vitro and in vivo, and inhibit the effect of LPS on the cell cycle, migration and invasion of human CRC cells in vitro. Administration of sTLR4/MD-2 complex protected mice from tumor both in xenograft and implantation metastasis model. The sTLR4/MD-2 complex treated mice had smaller tumor, less body weight loss and lower expression of inflammatory cytokines. Here, the azoxymethane/dextran sulfate sodium salt (AOM/DSS) murine model was used as an experimental platform to simulate the physiological and pathological processes of cancers associated with chronic intestinal inflammation. AOM/DSS-induced tumors were inhibited in mice treated by sTLR4/MD-2 complex. It is demonstrated in our study that sTLR4/MD-2 complex could inhibit CRC by competing with binding LPS, raising the complex's possibility of a new prevention agent against CRC. PMID:27409669

  4. Validity of the Medical College Admission Test for predicting MD-PhD student outcomes.

    PubMed

    Bills, James L; VanHouten, Jacob; Grundy, Michelle M; Chalkley, Roger; Dermody, Terence S

    2016-03-01

    The Medical College Admission Test (MCAT) is a quantitative metric used by MD and MD-PhD programs to evaluate applicants for admission. This study assessed the validity of the MCAT in predicting training performance measures and career outcomes for MD-PhD students at a single institution. The study population consisted of 153 graduates of the Vanderbilt Medical Scientist Training Program (combined MD-PhD program) who matriculated between 1963 and 2003 and completed dual-degree training. This population was divided into three cohorts corresponding to the version of the MCAT taken at the time of application. Multivariable regression (logistic for binary outcomes and linear for continuous outcomes) was used to analyze factors associated with outcome measures. The MCAT score and undergraduate GPA (uGPA) were treated as independent variables; medical and graduate school grades, time-to-PhD defense, USMLE scores, publication number, and career outcome were dependent variables. For cohort 1 (1963-1977), MCAT score was not associated with any assessed outcome, although uGPA was associated with medical school preclinical GPA and graduate school GPA (gsGPA). For cohort 2 (1978-1991), MCAT score was associated with USMLE Step II score and inversely correlated with publication number, and uGPA was associated with preclinical GPA (mspGPA) and clinical GPA (mscGPA). For cohort 3 (1992-2003), the MCAT score was associated with mscGPA, and uGPA was associated with gsGPA. Overall, MCAT score and uGPA were inconsistent or weak predictors of training metrics and career outcomes for this population of MD-PhD students.

  5. Office of Equal Opportunity Programs

    NASA Technical Reports Server (NTRS)

    Chin, Jennifer L.

    2004-01-01

    The NASA Glenn Office of Equal Opportunity Programs works to provide quality service for all programs and/or to assist the Center in becoming a model workplace. During the summer of 2004, I worked with Deborah Cotleur along with other staff members to create and modify customer satisfaction surveys. This office aims to assist in developing a model workplace by providing functions as a change agent to the center by serving as an advisor to management to ensure equity throughout the Center. In addition, the office serves as a mediator for the Center in addressing issues and concerns. Lastly, the office provides assistance to employees to enable attainment of personal and organizational goals. The Office of Equal Opportunities is a staff office which reports and provides advice to the Center Director and Executive Leadership, implements laws, regulations, and presidential executive orders, and provides center wide leadership and assistance to NASA GRC employees. Some of the major responsibilities of the office include working with the discrimination complaints program, special emphasis programs (advisory groups), management support, monitoring and evaluation, contract compliance, and community outreach. During my internship in this office, my main objective was to create four customer satisfaction surveys based on EO retreats, EO observances, EO advisory boards, and EO mediation/counseling. I created these surveys after conducting research on past events and surveys as well as similar survey research created and conducted by other NASA centers, program for EO Advisory group members, leadership training sessions for supervisors, preventing sexual harassment training sessions, and observance events. I also conducted research on the style and format from feedback surveys from the Marshall Equal Opportunity website, the Goddard website, and the main NASA website. Using the material from the Office of Equal Opportunity Programs at Glenn Research Center along with my

  6. 77 FR 57133 - T.J. Mcnichol, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-17

    ... the officer which shows that Respondent knew the undercover officer was a drug abuser and that he... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Drug... of the Drug Enforcement Administration, issued an Order to Show Cause and Immediate Suspension...

  7. Coding for urologic office procedures.

    PubMed

    Dowling, Robert A; Painter, Mark

    2013-11-01

    This article summarizes current best practices for documenting, coding, and billing common office-based urologic procedures. Topics covered include general principles, basic and advanced urologic coding, creation of medical records that support compliant coding practices, bundled codes and unbundling, global periods, modifiers for procedure codes, when to bill for evaluation and management services during the same visit, coding for supplies, and laboratory and radiology procedures pertinent to urology practice. Detailed information is included for the most common urology office procedures, and suggested resources and references are provided. This information is of value to physicians, office managers, and their coding staff.

  8. 33 CFR 165.556 - Regulated Navigation Area; Chesapeake and Delaware Canal, Chesapeake City Anchorage Basin, MD.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...; Chesapeake and Delaware Canal, Chesapeake City Anchorage Basin, MD. 165.556 Section 165.556 Navigation and..., Chesapeake City Anchorage Basin, MD. (a) Location. The following area is a regulated navigation area: All waters of the Chesapeake and Delaware (C & D) Canal within the anchorage basin at Chesapeake...

  9. Pathogenesis and protective efficacy of attenuated Meq null rMd5 virus in maternal antibody negative and commercial chickens.

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A serotype 1 Marek’s disease Meq null virus (rMd5'Meq) has been shown to be an excellent vaccine in maternal antibody positive (MAb+) chickens. The only drawback of this non-oncogenic virus is that, like parental rMd5, it retains the ability to induce bursa and thymus atrophy (BTA) in MAb- chickens....

  10. Registration of the Soft Red Winter Wheat Germplasm MD01W233-06-1 Resistant to Fusarium Head Blight

    Technology Transfer Automated Retrieval System (TEKTRAN)

    MD01W233-06-1 (Reg. No., PI ) is a soft red winter wheat (SRWW) (Triticum aestivum L.) germplasm line developed at the University of Maryland and released by the Maryland Agricultural Experiment Station in 2009. MD01W233-06-1 was selected from a cross of ‘McCormick’/ ‘Choptank’ made in 2001. McCorm...

  11. 33 CFR 334.170 - Chesapeake Bay, in the vicinity of Chesapeake Beach, Md.; firing range, Naval Research Laboratory.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... of Chesapeake Beach, Md.; firing range, Naval Research Laboratory. 334.170 Section 334.170 Navigation... RESTRICTED AREA REGULATIONS § 334.170 Chesapeake Bay, in the vicinity of Chesapeake Beach, Md.; firing range...-west line through Chesapeake Beach Light 2 at the entrance channel to Fishing Creek; on the south by...

  12. 33 CFR 334.170 - Chesapeake Bay, in the vicinity of Chesapeake Beach, Md.; firing range, Naval Research Laboratory.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... of Chesapeake Beach, Md.; firing range, Naval Research Laboratory. 334.170 Section 334.170 Navigation... RESTRICTED AREA REGULATIONS § 334.170 Chesapeake Bay, in the vicinity of Chesapeake Beach, Md.; firing range...-west line through Chesapeake Beach Light 2 at the entrance channel to Fishing Creek; on the south by...

  13. 33 CFR 334.170 - Chesapeake Bay, in the vicinity of Chesapeake Beach, Md.; firing range, Naval Research Laboratory.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... of Chesapeake Beach, Md.; firing range, Naval Research Laboratory. 334.170 Section 334.170 Navigation... RESTRICTED AREA REGULATIONS § 334.170 Chesapeake Bay, in the vicinity of Chesapeake Beach, Md.; firing range...-west line through Chesapeake Beach Light 2 at the entrance channel to Fishing Creek; on the south by...

  14. 33 CFR 334.170 - Chesapeake Bay, in the vicinity of Chesapeake Beach, Md.; firing range, Naval Research Laboratory.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... of Chesapeake Beach, Md.; firing range, Naval Research Laboratory. 334.170 Section 334.170 Navigation... RESTRICTED AREA REGULATIONS § 334.170 Chesapeake Bay, in the vicinity of Chesapeake Beach, Md.; firing range...-west line through Chesapeake Beach Light 2 at the entrance channel to Fishing Creek; on the south by...

  15. 33 CFR 334.170 - Chesapeake Bay, in the vicinity of Chesapeake Beach, Md.; firing range, Naval Research Laboratory.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... of Chesapeake Beach, Md.; firing range, Naval Research Laboratory. 334.170 Section 334.170 Navigation... RESTRICTED AREA REGULATIONS § 334.170 Chesapeake Bay, in the vicinity of Chesapeake Beach, Md.; firing range...-west line through Chesapeake Beach Light 2 at the entrance channel to Fishing Creek; on the south by...

  16. 77 FR 39209 - Foreign-Trade Zone 74-Baltimore, MD, Notification of Proposed Production Activity, J.D. Neuhaus...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-02

    ... Foreign-Trade Zones Board Foreign-Trade Zone 74--Baltimore, MD, Notification of Proposed Production Activity, J.D. Neuhaus LP (Overhead Lifting Equipment Production) Sparks, MD The Baltimore Development Corporation, grantee of FTZ 74, submitted a notification of proposed production activity on behalf of...

  17. 77 FR 63290 - Foreign-Trade Zone 74-Baltimore, MD, Authorization of Production Activity, J.D. Neuhaus LP...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-16

    ... Foreign-Trade Zones Board Foreign-Trade Zone 74--Baltimore, MD, Authorization of Production Activity, J.D. Neuhaus LP, (Overhead Lifting Equipment Production), Sparks, MD On June 13, 2012, the Baltimore Development Corporation, grantee of FTZ 74, submitted a notification of proposed production activity on...

  18. Draft Genome Sequence of Ralstonia sp. MD27, a Poly(3-Hydroxybutyrate)-Degrading Bacterium, Isolated from Compost

    PubMed Central

    Zhu, Morgan; McCully, Lucy M.; Silby, Mark W.; Charles-Ogan, Tamunonengiyeofori I.

    2015-01-01

    Ralstonia sp. strain MD27, a novel biopolymer-degrading betaproteobacterium, was isolated from compost samples. This organism has been shown to utilize the biopolymer poly(3-hydroxybutyrate) [P(3HB)] as a carbon source for growth. We report the draft genome sequence of MD27 with an estimated total sequence length of 5.9 Mb. PMID:26450738

  19. 78 FR 28229 - Prospective Grant of Exclusive License: Device and System for Expression Microdissection (xMD)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-14

    ..., a company having a place of business in Maryland. The patent rights in these inventions have been... micro-dissection of biological specimens, as covered by the Licensed Patents Rights (the ``Exclusive Field''). xMD Diagnostics, LLC (xMD) shall be the only entity granted rights in the Exclusive Field...

  20. 33 CFR 334.190 - Chesapeake Bay, in vicinity of Bloodsworth Island, MD, U.S. Navy.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Bloodsworth Island, MD, U.S. Navy. 334.190 Section 334.190 Navigation and Navigable Waters CORPS OF ENGINEERS... Chesapeake Bay, in vicinity of Bloodsworth Island, MD, U.S. Navy. (a) The areas—(1) Prohibited area. All...″; Bloodsworth Island, Pone Island, Northeast Island, and Adams Island. (2) The danger zone. All waters...

  1. 33 CFR 334.155 - Severn River, Naval Station Annapolis, Small Boat Basin, Annapolis, MD; naval restricted area.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Annapolis, Small Boat Basin, Annapolis, MD; naval restricted area. 334.155 Section 334.155 Navigation and... RESTRICTED AREA REGULATIONS § 334.155 Severn River, Naval Station Annapolis, Small Boat Basin, Annapolis, MD; naval restricted area. (a) The area. The waters within the Naval Station Annapolis small boat basin...

  2. 33 CFR 334.155 - Severn River, Naval Station Annapolis, Small Boat Basin, Annapolis, MD; naval restricted area.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Annapolis, Small Boat Basin, Annapolis, MD; naval restricted area. 334.155 Section 334.155 Navigation and... RESTRICTED AREA REGULATIONS § 334.155 Severn River, Naval Station Annapolis, Small Boat Basin, Annapolis, MD; naval restricted area. (a) The area. The waters within the Naval Station Annapolis small boat basin...

  3. 33 CFR 334.155 - Severn River, Naval Station Annapolis, Small Boat Basin, Annapolis, MD; naval restricted area.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Annapolis, Small Boat Basin, Annapolis, MD; naval restricted area. 334.155 Section 334.155 Navigation and... RESTRICTED AREA REGULATIONS § 334.155 Severn River, Naval Station Annapolis, Small Boat Basin, Annapolis, MD; naval restricted area. (a) The area. The waters within the Naval Station Annapolis small boat basin...

  4. 33 CFR 334.155 - Severn River, Naval Station Annapolis, Small Boat Basin, Annapolis, MD; naval restricted area.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Annapolis, Small Boat Basin, Annapolis, MD; naval restricted area. 334.155 Section 334.155 Navigation and... RESTRICTED AREA REGULATIONS § 334.155 Severn River, Naval Station Annapolis, Small Boat Basin, Annapolis, MD; naval restricted area. (a) The area. The waters within the Naval Station Annapolis small boat basin...

  5. 33 CFR 334.155 - Severn River, Naval Station Annapolis, Small Boat Basin, Annapolis, MD; naval restricted area.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Annapolis, Small Boat Basin, Annapolis, MD; naval restricted area. 334.155 Section 334.155 Navigation and... RESTRICTED AREA REGULATIONS § 334.155 Severn River, Naval Station Annapolis, Small Boat Basin, Annapolis, MD; naval restricted area. (a) The area. The waters within the Naval Station Annapolis small boat basin...

  6. The Convergence of Business and Medicine: A Study of MD/MBA Programs in the United States

    ERIC Educational Resources Information Center

    Keogh, Timothy J.; Martin, William Marty

    2011-01-01

    The purpose of this paper is to identify the convergence of business and medical education and describe the curricula of MD/MBA (Medical Doctor/Master of Business Administration) programs in the US. The focus of this study is to provide a guide to dual MD/MBA programs for physicians, aspiring physicians, policy makers and healthcare organizations.…

  7. Characterizing a point mutation within the UL5 gene that reduces in vivo replication and MD incidence

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Marek’s disease virus (MDV) is an oncogenic alphaherpesvirus of chickens and the causative agent for Marek’s disease (MD). Vaccination is the primary method to control MD. Despite the success of vaccination, more virulent field strains are evolving, requiring the development of new vaccines. Attenua...

  8. 76 FR 67472 - Order of Succession for the Office of the Chief Information Officer

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-01

    ... Cyber Security and Privacy, Office of the Chief Information Officer, Department of Housing and Urban... Operations; (3) Deputy Chief Information Officer, for Cyber Security and Privacy; (4) Deputy...

  9. Collaborators | Office of Cancer Genomics

    Cancer.gov

    The TARGET initiative is jointly managed within the National Cancer Institute (NCI) by the Office of Cancer Genomics (OCG)Opens in a New Tab and the Cancer Therapy Evaluation Program (CTEP)Opens in a New Tab.

  10. Ergonomic Training for Tomorrow's Office.

    ERIC Educational Resources Information Center

    Gross, Clifford M.; Chapnik, Elissa Beth

    1987-01-01

    The authors focus on issues related to the continual use of video display terminals in the office, including safety and health regulations, potential health problems, and the role of training in minimizing work-related health problems. (CH)

  11. Preparing for an Office Visit

    MedlinePlus

    ... Concussion Toolkit Support Organizations Activities and Events Neuro Film Festival Brain Health Fair Buy a Brain About ... the office if they prefer copies of the films or if reports are adequate. You may also ...

  12. Office Automation Boosts University's Productivity.

    ERIC Educational Resources Information Center

    School Business Affairs, 1986

    1986-01-01

    The University of Pittsburgh has a 2-year agreement designating the Xerox Corporation as the primary supplier of word processing and related office automation equipment in order to increase productivity and more efficient use of campus resources. (MLF)

  13. Office Automation at Memphis State.

    ERIC Educational Resources Information Center

    Smith, R. Eugene; And Others

    1986-01-01

    The development of a university-wide office automation plan, beginning with a short-range pilot project and a five-year plan for the entire organization with the potential for modular implementation, is described. (MSE)

  14. Assessing an office chemistry instrument.

    PubMed

    Baer, D M; Belsey, R E

    1986-12-01

    Selection of appropriate testing systems depends on the characteristics and needs of the office. Clinical practice needs, work flow needs, and the analyst's ability must be balanced against the level of system complexity, automation, quality characteristics, and cost.

  15. Law Enforcement Officers Equity Act

    THOMAS, 111th Congress

    Rep. Filner, Bob [D-CA-51

    2009-01-26

    05/04/2009 Referred to the Subcommittee on Federal Workforce, Post Office, and the District of Columbia. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  16. Central-Office Real Estate.

    ERIC Educational Resources Information Center

    Pardini, Priscilla

    2003-01-01

    Describes how to upgrade a school district's central-office facilities without incurring taxpayer enmity. Includes case studies from Harford County, Maryland; Orange and Broward Counties, Florida; South Milwaukee, Wisconsin; Mt. Baker, Washington; Chicago, Illinois; and Rochester, New Hampshire. (PKP)

  17. 7 CFR 600.6 - Field offices.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Field offices. 600.6 Section 600.6 Agriculture... AGRICULTURE GENERAL ORGANIZATION § 600.6 Field offices. Each field office is under the direction and... served by the field office. Usually the geographical area of a field office includes one or...

  18. 7 CFR 600.6 - Field offices.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Field offices. 600.6 Section 600.6 Agriculture... AGRICULTURE GENERAL ORGANIZATION § 600.6 Field offices. Each field office is under the direction and... served by the field office. Usually the geographical area of a field office includes one or...

  19. 7 CFR 600.6 - Field offices.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Field offices. 600.6 Section 600.6 Agriculture... AGRICULTURE GENERAL ORGANIZATION § 600.6 Field offices. Each field office is under the direction and... served by the field office. Usually the geographical area of a field office includes one or...

  20. 7 CFR 600.6 - Field offices.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Field offices. 600.6 Section 600.6 Agriculture... AGRICULTURE GENERAL ORGANIZATION § 600.6 Field offices. Each field office is under the direction and... served by the field office. Usually the geographical area of a field office includes one or...

  1. 7 CFR 600.6 - Field offices.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Field offices. 600.6 Section 600.6 Agriculture... AGRICULTURE GENERAL ORGANIZATION § 600.6 Field offices. Each field office is under the direction and... served by the field office. Usually the geographical area of a field office includes one or...

  2. 12 CFR 583.13 - Office.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Office. 583.13 Section 583.13 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY DEFINITIONS FOR REGULATIONS AFFECTING SAVINGS AND LOAN HOLDING COMPANIES § 583.13 Office. The term Office means the Office of Thrift Supervision....

  3. 12 CFR 561.34 - Office.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Office. 561.34 Section 561.34 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY DEFINITIONS FOR REGULATIONS AFFECTING ALL SAVINGS ASSOCIATIONS § 561.34 Office. The term Office means the Office as established in section 3 of...

  4. 49 CFR 1325.3 - Federal office.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Federal office. 1325.3 Section 1325.3... FEDERAL OFFICE OR THEIR REPRESENTATIVES § 1325.3 Federal office. For the purposes of this section, Federal office means the office of President or Vice President of the United States; or of Senator...

  5. 12 CFR 619.9310 - Senior officer.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Senior officer. 619.9310 Section 619.9310 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM DEFINITIONS § 619.9310 Senior officer. The Chief Executive Officer, the Chief Operations Officer, the Chief Financial Officer, the Chief...

  6. 29 CFR 401.14 - Officer.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 2 2010-07-01 2010-07-01 false Officer. 401.14 Section 401.14 Labor Regulations Relating to Labor OFFICE OF LABOR-MANAGEMENT STANDARDS, DEPARTMENT OF LABOR LABOR-MANAGEMENT STANDARDS MEANING OF TERMS USED IN THIS SUBCHAPTER § 401.14 Officer. Officer means any constitutional officer,...

  7. 29 CFR 401.18 - Office.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 2 2010-07-01 2010-07-01 false Office. 401.18 Section 401.18 Labor Regulations Relating to Labor OFFICE OF LABOR-MANAGEMENT STANDARDS, DEPARTMENT OF LABOR LABOR-MANAGEMENT STANDARDS MEANING OF TERMS USED IN THIS SUBCHAPTER § 401.18 Office. Office means the Office of Labor-Management...

  8. 75 FR 58410 - Office of Biotechnology Activities, Office of Science Policy, Office of the Director; Notice of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-24

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Office of Biotechnology Activities, Office of Science... of Biotechnology Activities, 6705 Rockledge Drive, Suite 750, Bethesda, Maryland 20892, (301)...

  9. Officer Overexecution: Analysis and Solutions

    DTIC Science & Technology

    2015-08-01

    accessions. We also found that female SWOs with a nuclear subspecialty are the only SWOs whose retention appears to be affected by the level of OOE in their...occurs for several reasons. First, like other Navy officer career paths, the SWO career path is essentially closed. SWOs must begin their careers at...actions that could be taken to address OOE while also achieving other Navy goals (e.g., increasing the number of female officers). In addition, N9I

  10. Contact | Office of Cancer Genomics

    Cancer.gov

    For more information about the Office of Cancer Genomics, please contact: Office of Cancer Genomics National Cancer Institute 31 Center Drive, 10A07 Bethesda, Maryland 20892-2580 Phone: (301) 451-8027 Fax: (301) 480-4368 Email: ocg@mail.nih.gov *Please note that this site will not function properly in Internet Explorer unless you completely turn off the Compatibility View*

  11. Assessing the allelotypic effect of two aminocyclopropane carboxylic acid synthase-encoding genes MdACS1 and MdACS3a on fruit ethylene production and softening in Malus

    PubMed Central

    Dougherty, Laura; Zhu, Yuandi; Xu, Kenong

    2016-01-01

    Phytohormone ethylene largely determines apple fruit shelf life and storability. Previous studies demonstrated that MdACS1 and MdACS3a, which encode 1-aminocyclopropane-1-carboxylic acid synthases (ACS), are crucial in apple fruit ethylene production. MdACS1 is well-known to be intimately involved in the climacteric ethylene burst in fruit ripening, while MdACS3a has been regarded a main regulator for ethylene production transition from system 1 (during fruit development) to system 2 (during fruit ripening). However, MdACS3a was also shown to have limited roles in initiating the ripening process lately. To better assess their roles, fruit ethylene production and softening were evaluated at five time points during a 20-day post-harvest period in 97 Malus accessions and in 34 progeny from 2 controlled crosses. Allelotyping was accomplished using an existing marker (ACS1) for MdACS1 and two markers (CAPS866 and CAPS870) developed here to specifically detect the two null alleles (ACS3a-G289V and Mdacs3a) of MdACS3a. In total, 952 Malus accessions were allelotyped with the three markers. The major findings included: The effect of MdACS1 was significant on fruit ethylene production and softening while that of MdACS3a was less detectable; allele MdACS1–2 was significantly associated with low ethylene and slow softening; under the same background of the MdACS1 allelotypes, null allele Mdacs3a (not ACS3a-G289V) could confer a significant delay of ethylene peak; alleles MdACS1–2 and Mdacs3a (excluding ACS3a-G289V) were highly enriched in M. domestica and M. hybrid when compared with those in M. sieversii. These findings are of practical implications in developing apples of low and delayed ethylene profiles by utilizing the beneficial alleles MdACS1-2 and Mdacs3a. PMID:27231553

  12. MdMYB1 Regulates Anthocyanin and Malate Accumulation by Directly Facilitating Their Transport into Vacuoles in Apples1[OPEN

    PubMed Central

    Hu, Da-Gang; Sun, Cui-Hui; Ma, Qi-Jun; You, Chun-Xiang; Hao, Yu-Jin

    2016-01-01

    Tonoplast transporters, including proton pumps and secondary transporters, are essential for plant cell function and for quality formation of fleshy fruits and ornamentals. Vacuolar transport of anthocyanins, malate, and other metabolites is directly or indirectly dependent on the H+-pumping activities of vacuolar H+-ATPase (VHA) and/or vacuolar H+-pyrophosphatase, but how these proton pumps are regulated in modulating vacuolar transport is largely unknown. Here, we report a transcription factor, MdMYB1, in apples that binds to the promoters of two genes encoding the B subunits of VHA, MdVHA-B1 and MdVHA-B2, to transcriptionally activate its expression, thereby enhancing VHA activity. A series of transgenic analyses in apples demonstrates that MdMYB1/10 controls cell pH and anthocyanin accumulation partially by regulating MdVHA-B1 and MdVHA-B2. Furthermore, several other direct target genes of MdMYB10 are identified, including MdVHA-E2, MdVHP1, MdMATE-LIKE1, and MdtDT, which are involved in H+-pumping or in the transport of anthocyanins and malates into vacuoles. Finally, we show that the mechanism by which MYB controls malate and anthocyanin accumulation in apples also operates in Arabidopsis (Arabidopsis thaliana). These findings provide novel insights into how MYB transcription factors directly modulate the vacuolar transport system in addition to anthocyanin biosynthesis, consequently controlling organ coloration and cell pH in plants. PMID:26637549

  13. Species-specific activation of TLR4 by hypoacylated endotoxins governed by residues 82 and 122 of MD-2.

    PubMed

    Oblak, Alja; Jerala, Roman

    2014-01-01

    The Toll-like receptor 4/MD-2 receptor complex recognizes endotoxin, a Gram-negative bacterial cell envelope component. Recognition of the most potent hexaacylated form of endotoxin is mediated by the sixth acyl chain that protrudes from the MD-2 hydrophobic pocket and bridges TLR4/MD-2 to the neighboring TLR4 ectodomain, driving receptor dimerization via hydrophobic interactions. In hypoacylated endotoxins all acyl chains could be accommodated within the binding pocket of the human hMD-2. Nevertheless, tetra- and pentaacylated endotoxins activate the TLR4/MD-2 receptor of several species. We observed that amino acid residues 82 and 122, located at the entrance to the endotoxin binding site of MD-2, have major influence on the species-specific endotoxin recognition. We show that substitution of hMD-2 residue V82 with an amino acid residue with a bulkier hydrophobic side chain enables activation of TLR4/MD-2 by pentaacylated and tetraacylated endotoxins. Interaction of the lipid A phosphate group with the amino acid residue 122 of MD-2 facilitates the appropriate positioning of the hypoacylated endotoxin. Moreover, mouse TLR4 contributes to the agonistic effect of pentaacylated msbB endotoxin. We propose a molecular model that explains how the molecular differences between the murine or equine MD-2, which both have sufficiently large hydrophobic pockets to accommodate all five or four acyl chains, influence the positioning of endotoxin so that one of the acyl chains remains outside the pocket and enables hydrophobic interactions with TLR4, leading to receptor activation.

  14. PoopMD, a Mobile Health Application, Accurately Identifies Infant Acholic Stools.

    PubMed

    Franciscovich, Amy; Vaidya, Dhananjay; Doyle, Joe; Bolinger, Josh; Capdevila, Montserrat; Rice, Marcus; Hancock, Leslie; Mahr, Tanya; Mogul, Douglas B

    2015-01-01

    Biliary atresia (BA) is the leading cause of pediatric end-stage liver disease in the United States. Education of parents in the perinatal period with stool cards depicting acholic and normal stools has been associated with improved time-to-diagnosis and survival in BA. PoopMD is a mobile application that utilizes a smartphone's camera and color recognition software to analyze an infant's stool and determine if additional follow-up is indicated. PoopMD was developed using custom HTML5/CSS3 and wrapped to work on iOS and Android platforms. In order to define the gold standard regarding stool color, seven pediatricians were asked to review 45 photographs of infant stool and rate them as acholic, normal, or indeterminate. Samples for which 6+ pediatricians demonstrated agreement defined the gold standard, and only these samples were included in the analysis. Accuracy of PoopMD was assessed using an iPhone 5s with incandescent lighting. Variability in analysis of stool photographs as acholic versus normal with intermediate rating weighted as 50% agreement (kappa) was compared between three laypeople and one expert user. Variability in output was also assessed between an iPhone 5s and a Samsung Galaxy S4, as well as between incandescent lighting and compact fluorescent lighting. Six-plus pediatricians agreed on 27 normal and 7 acholic photographs; no photographs were defined as indeterminate. The sensitivity was 7/7 (100%). The specificity was 24/27 (89%) with 3/27 labeled as indeterminate; no photos of normal stool were labeled as acholic. The Laplace-smoothed positive likelihood ratio was 6.44 (95% CI 2.52 to 16.48) and the negative likelihood ratio was 0.13 (95% CI 0.02 to 0.83). kappauser was 0.68, kappaphone was 0.88, and kappalight was 0.81. Therefore, in this pilot study, PoopMD accurately differentiates acholic from normal color with substantial agreement across users, and almost perfect agreement across two popular smartphones and ambient light settings. PoopMD

  15. Effects of office innovation on office workers' health and performance.

    PubMed

    Meijer, Eline M; Frings-Dresen, Monique H W; Sluiter, Judith K

    2009-09-01

    The implementation of an innovative office concept (e.g. open-plan, flexible workplaces and a paperless office concept) on health and productivity among office workers was evaluated with questionnaires of 138 workers at baseline and 6 and 15 months afterwards. Work-related fatigue, general health, change in health status, upper extremity complaints and perceived productivity were outcomes. No short-term significant differences were found in most outcomes except for quantity of performed work (decrease from 96% to 92%, p = 0.008). In the long-term, no significant differences were found in most outcomes except for an increase in general health (p = 0.011) and a decrease in prevalences of upper extremity complaints (33% to 22%, p = 0.021). Perceived productivity increased significantly 15 months after the implementation. It is concluded that innovative office concepts had no or limited effects on work-related fatigue, health changes and productivity but some positive effects on workers' general health and upper extremity complaints in the long term. Office innovation is being administered often but up to now seldom evaluated on workers' health and productivity.

  16. 76 FR 19149 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-06

    ... From the Federal Register Online via the Government Publishing Office POSTAL REGULATORY COMMISSION Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Wesleyville Post Office in...

  17. 75 FR 77921 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-14

    ... From the Federal Register Online via the Government Publishing Office POSTAL REGULATORY COMMISSION Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice; correction. SUMMARY: The... an appeal of the closing of the Graves Mill, Virginia post office. The procedural schedule...

  18. 76 FR 11824 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-03

    ... From the Federal Register Online via the Government Publishing Office POSTAL REGULATORY COMMISSION Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Mitchellville Post Office in...

  19. 77 FR 3806 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-25

    ... From the Federal Register Online via the Government Publishing Office POSTAL REGULATORY COMMISSION Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document... Station post office in Yerington, Nevada. The first petition for review received December 28, 2011,...

  20. 75 FR 55785 - Office of Special Education Programs, Office of Special Education and Rehabilitative Services...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-14

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF EDUCATION Office of Special Education Programs, Office of Special Education and Rehabilitative Services, Department... Office of Special Education Programs (OSEP) funds NCEO to address national, State, and local...