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Sample records for mdt-15 confers metabolic

  1. The Mediator Subunit MDT-15 Confers Metabolic Adaptation to Ingested Material

    PubMed Central

    Taubert, Stefan; Hansen, Malene; Van Gilst, Marc R.; Cooper, Samantha B.; Yamamoto, Keith R.

    2008-01-01

    In eukaryotes, RNA polymerase II (PolII) dependent gene expression requires accessory factors termed transcriptional coregulators. One coregulator that universally contributes to PolII-dependent transcription is the Mediator, a multisubunit complex that is targeted by many transcriptional regulatory factors. For example, the Caenorhabditis elegans Mediator subunit MDT-15 confers the regulatory actions of the sterol response element binding protein SBP-1 and the nuclear hormone receptor NHR-49 on fatty acid metabolism. Here, we demonstrate that MDT-15 displays a broader spectrum of activities, and that it integrates metabolic responses to materials ingested by C. elegans. Depletion of MDT-15 protein or mutation of the mdt-15 gene abrogated induction of specific detoxification genes in response to certain xenobiotics or heavy metals, rendering these animals hypersensitive to toxin exposure. Intriguingly, MDT-15 appeared to selectively affect stress responses related to ingestion, as MDT-15 functional defects did not abrogate other stress responses, e.g., thermotolerance. Together with our previous finding that MDT-15:NHR-49 regulatory complexes coordinate a sector of the fasting response, we propose a model whereby MDT-15 integrates several transcriptional regulatory pathways to monitor both the availability and quality of ingested materials, including nutrients and xenobiotic compounds. PMID:18454197

  2. A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans.

    PubMed

    Taubert, Stefan; Van Gilst, Marc R; Hansen, Malene; Yamamoto, Keith R

    2006-05-01

    The Caenorhabditis elegans Nuclear Hormone Receptor NHR-49 coordinates expression of fatty acid (FA) metabolic genes during periods of feeding and in response to fasting. Here we report the identification of MDT-15, a subunit of the C. elegans Mediator complex, as an NHR-49-interacting protein and transcriptional coactivator. Knockdown of mdt-15 by RNA interference (RNAi) prevented fasting-induced mRNA accumulation of NHR-49 targets in vivo, and fasting-independent expression of other NHR-49 target genes, including two FA-Delta9-desaturases (fat-5, fat-7). Interestingly, mdt-15 RNAi affected additional FA-metabolism genes (including the third FA-Delta9-desaturase, fat-6) that are regulated independently of NHR-49, suggesting that distinct unidentified regulatory factors also recruit MDT-15 to selectively modulate metabolic gene expression. The deregulation of FA-Delta9-desaturases by knockdown of mdt-15 correlated with dramatically decreased levels of unsaturated FAs and multiple deleterious phenotypes (short life span, sterility, uncoordinated locomotion, and morphological defects). Importantly, dietary addition of specific polyunsaturated FAs partially suppressed these pleiotropic phenotypes. Thus, failure to properly govern FA-Delta9-desaturation contributed to decreased nematode viability. Our findings imply that a single subunit of the Mediator complex, MDT-15, integrates the activities of several distinct regulatory factors to coordinate metabolic and hormonal regulation of FA metabolism.

  3. A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans

    PubMed Central

    Taubert, Stefan; Van Gilst, Marc R.; Hansen, Malene; Yamamoto, Keith R.

    2006-01-01

    The Caenorhabditis elegans Nuclear Hormone Receptor NHR-49 coordinates expression of fatty acid (FA) metabolic genes during periods of feeding and in response to fasting. Here we report the identification of MDT-15, a subunit of the C. elegans Mediator complex, as an NHR-49-interacting protein and transcriptional coactivator. Knockdown of mdt-15 by RNA interference (RNAi) prevented fasting-induced mRNA accumulation of NHR-49 targets in vivo, and fasting-independent expression of other NHR-49 target genes, including two FA-Δ9-desaturases (fat-5, fat-7). Interestingly, mdt-15 RNAi affected additional FA-metabolism genes (including the third FA-Δ9-desaturase, fat-6) that are regulated independently of NHR-49, suggesting that distinct unidentified regulatory factors also recruit MDT-15 to selectively modulate metabolic gene expression. The deregulation of FA-Δ9-desaturases by knockdown of mdt-15 correlated with dramatically decreased levels of unsaturated FAs and multiple deleterious phenotypes (short life span, sterility, uncoordinated locomotion, and morphological defects). Importantly, dietary addition of specific polyunsaturated FAs partially suppressed these pleiotropic phenotypes. Thus, failure to properly govern FA-Δ9-desaturation contributed to decreased nematode viability. Our findings imply that a single subunit of the Mediator complex, MDT-15, integrates the activities of several distinct regulatory factors to coordinate metabolic and hormonal regulation of FA metabolism. PMID:16651656

  4. AMP-Activated Protein Kinase Regulates Oxidative Metabolism in Caenorhabditis elegans through the NHR-49 and MDT-15 Transcriptional Regulators

    PubMed Central

    Moreno-Arriola, Elizabeth; EL Hafidi, Mohammed; Ortega-Cuéllar, Daniel; Carvajal, Karla

    2016-01-01

    Cellular energy regulation relies on complex signaling pathways that respond to fuel availability and metabolic demands. Dysregulation of these networks is implicated in the development of human metabolic diseases such as obesity and metabolic syndrome. In Caenorhabditis elegans the AMP-activated protein kinase, AAK, has been associated with longevity and stress resistance; nevertheless its precise role in energy metabolism remains elusive. In the present study, we find an evolutionary conserved role of AAK in oxidative metabolism. Similar to mammals, AAK is activated by AICAR and metformin and leads to increased glycolytic and oxidative metabolic fluxes evidenced by an increase in lactate levels and mitochondrial oxygen consumption and a decrease in total fatty acids and lipid storage, whereas augmented glucose availability has the opposite effects. We found that these changes were largely dependent on the catalytic subunit AAK-2, since the aak-2 null strain lost the observed metabolic actions. Further results demonstrate that the effects due to AAK activation are associated to SBP-1 and NHR-49 transcriptional factors and MDT-15 transcriptional co-activator, suggesting a regulatory pathway that controls oxidative metabolism. Our findings establish C. elegans as a tractable model system to dissect the relationship between distinct molecules that play a critical role in the regulation of energy metabolism in human metabolic diseases. PMID:26824904

  5. The conserved Mediator subunit MDT-15 is required for oxidative stress responses in Caenorhabditis elegans

    PubMed Central

    Goh, Grace Y S; Martelli, Katherine L; Parhar, Kulveer S; Kwong, Ada W L; Wong, Marcus A; Mah, Allan; Hou, Nicole S; Taubert, Stefan

    2014-01-01

    Reactive oxygen species (ROS) play important signaling roles in metazoans, but also cause significant molecular damage. Animals tightly control ROS levels using sophisticated defense mechanisms, yet the transcriptional pathways that induce ROS defense remain incompletely understood. In the nematode Caenorhabditis elegans, the transcription factor SKN-1 is considered a master regulator for detoxification and oxidative stress responses. Here, we show that MDT-15, a subunit of the conserved Mediator complex, is also required for oxidative stress responses in nematodes. Specifically, mdt-15 is required to express SKN-1 targets upon chemical and genetic increase in SKN-1 activity. mdt-15 is also required to express genes in SKN-1-dependent and SKN-1-independent fashions downstream of insulin/IGF-1 signaling and for the longevity of daf-2/insulin receptor mutants. At the molecular level, MDT-15 binds SKN-1 through a region distinct from the classical transcription-factor-binding KIX-domain. Moreover, mdt-15 is essential for the transcriptional response to and survival on the organic peroxide tert-butyl-hydroperoxide (tBOOH), a largely SKN-1-independent response. The MDT-15 interacting nuclear hormone receptor, NHR-64, is specifically required for tBOOH but not arsenite resistance, but NHR-64 is dispensable for the transcriptional response to tBOOH. Hence, NHR-64 and MDT-15’s mode of action remain elusive. Lastly, the role of MDT-15 in oxidative stress defense is functionally separable from its function in fatty acid metabolism, as exogenous polyunsaturated fatty acid complementation rescues developmental, but not stress sensitivity phenotypes of mdt-15 worms. Our findings reveal novel conserved players in the oxidative stress response and suggest a broad cytoprotective role for MDT-15. PMID:23957350

  6. SREBP and MDT-15 protect C. elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat

    PubMed Central

    Lee, Dongyeop; Jeong, Dae-Eun; Son, Heehwa G.; Yamaoka, Yasuyo; Kim, Hyunmin; Seo, Keunhee; Khan, Abdul Aziz; Roh, Tae-Young; Moon, Dae Won; Lee, Youngsook; Lee, Seung-Jae V.

    2015-01-01

    Glucose-rich diets shorten the life spans of various organisms. However, the metabolic processes involved in this phenomenon remain unknown. Here, we show that sterol regulatory element-binding protein (SREBP) and mediator-15 (MDT-15) prevent the life-shortening effects of a glucose-rich diet by regulating fat-converting processes in Caenorhabditis elegans. Up-regulation of the SREBP/MDT-15 transcription factor complex was necessary and sufficient for alleviating the life-shortening effect of a glucose-rich diet. Glucose feeding induced key enzymes that convert saturated fatty acids (SFAs) to unsaturated fatty acids (UFAs), which are regulated by SREBP and MDT-15. Furthermore, SREBP/MDT-15 reduced the levels of SFAs and moderated glucose toxicity on life span. Our study may help to develop strategies against elevated blood glucose and free fatty acids, which cause glucolipotoxicity in diabetic patients. PMID:26637528

  7. Metabolic Engineering X Conference

    SciTech Connect

    Flach, Evan

    2015-05-07

    The International Metabolic Engineering Society (IMES) and the Society for Biological Engineering (SBE), both technological communities of the American Institute of Chemical Engineers (AIChE), hosted the Metabolic Engineering X Conference (ME-X) on June 15-19, 2014 at the Westin Bayshore in Vancouver, British Columbia. It attracted 395 metabolic engineers from academia, industry and government from around the globe.

  8. Metabolic Engineering VII Conference

    SciTech Connect

    Kevin Korpics

    2012-12-04

    The aims of this Metabolic Engineering conference are to provide a forum for academic and industrial researchers in the field; to bring together the different scientific disciplines that contribute to the design, analysis and optimization of metabolic pathways; and to explore the role of Metabolic Engineering in the areas of health and sustainability. Presentations, both written and oral, panel discussions, and workshops will focus on both applications and techniques used for pathway engineering. Various applications including bioenergy, industrial chemicals and materials, drug targets, health, agriculture, and nutrition will be discussed. Workshops focused on technology development for mathematical and experimental techniques important for metabolic engineering applications will be held for more in depth discussion. This 2008 meeting will celebrate our conference tradition of high quality and relevance to both industrial and academic participants, with topics ranging from the frontiers of fundamental science to the practical aspects of metabolic engineering.

  9. The Evolutionarily Conserved Mediator Subunit MDT-15/MED15 Links Protective Innate Immune Responses and Xenobiotic Detoxification

    PubMed Central

    McEwan, Deborah L.; Conery, Annie L.; Ausubel, Frederick M.

    2014-01-01

    Metazoans protect themselves from environmental toxins and virulent pathogens through detoxification and immune responses. We previously identified a small molecule xenobiotic toxin that extends survival of Caenorhabditis elegans infected with human bacterial pathogens by activating the conserved p38 MAP kinase PMK-1 host defense pathway. Here we investigate the cellular mechanisms that couple activation of a detoxification response to innate immunity. From an RNAi screen of 1,420 genes expressed in the C. elegans intestine, we identified the conserved Mediator subunit MDT-15/MED15 and 28 other gene inactivations that abrogate the induction of PMK-1-dependent immune effectors by this small molecule. We demonstrate that MDT-15/MED15 is required for the xenobiotic-induced expression of p38 MAP kinase PMK-1-dependent immune genes and protection from Pseudomonas aeruginosa infection. We also show that MDT-15 controls the induction of detoxification genes and functions to protect the host from bacteria-derived phenazine toxins. These data define a central role for MDT-15/MED15 in the coordination of xenobiotic detoxification and innate immune responses. PMID:24875643

  10. 2007 Plant Metabolic Engineering Gordon Conference and Graduate Research Seminar

    SciTech Connect

    Erich Grotewold

    2008-09-15

    Plant Metabolic Engineering is an emerging field that integrates a diverse range of disciplines including plant genetics, genomics, biochemistry, chemistry and cell biology. The Gordon-Kenan Graduate Research Seminar (GRS) in Plant Metabolic Engineering was initiated to provide a unique opportunity for future researcher leaders to present their work in this field. It also creates an environment allowing for peer-review and critical assessment of work without the intimidation usually associated with the presence of senior investigators. The GRS immediately precedes the Plant Metabolic Engineering Gordon Research Conference and will be for and by graduate students and post-docs, with the assistance of the organizers listed.

  11. 2011 Plant Lipids: Structure, Metabolism, & Function Gordon Research Conference

    SciTech Connect

    Christopher Benning

    2011-02-04

    This is the second Gordon Research Conference on 'Plant Lipids: Structure, Metabolism & Function'. It covers current topics in lipid structure, metabolism and function in eukaryotic photosynthetic organisms including seed plants, algae, mosses and ferns. Work in photosynthetic bacteria is considered as well as it serves the understanding of specific aspects of lipid metabolism in plants. Breakthroughs are discussed in research on plant lipids as diverse as glycerolipids, sphingolipids, lipids of the cell surface, isoprenoids, fatty acids and their derivatives. The program covers nine concepts at the forefront of research under which afore mentioned plant lipid classes are discussed. The goal is to integrate areas such as lipid signaling, basic lipid metabolism, membrane function, lipid analysis, and lipid engineering to achieve a high level of stimulating interaction among diverse researchers with interests in plant lipids. One Emphasis is on the dynamics and regulation of lipid metabolism during plant cell development and in response to environmental factors.

  12. The 2009 stock conference report: inflammation, obesity and metabolic disease.

    PubMed

    Hevener, A L; Febbraio, M A

    2010-09-01

    Obesity is linked with many deleterious health consequences and is associated with increased risk of chronic disease including type 2 diabetes, atherosclerosis and certain forms of cancer. Recent work has highlighted the impact of obesity to activate inflammatory gene networks and suggests a causal function of inflammation in the pathogenesis of the metabolic syndrome. Since 2005, when Dr Gokhan Hotamisligil chaired the fourth Stock Conference in Istanbul, Turkey, entitled 'Obesity and Inflammation', there has been an explosion of studies investigating the relationship between obesity, inflammation and substrate metabolism. The exuberance surrounding this field of research is exemplified by the body of work that has been published in these past 4 years, including over 1400 publications. During this time, several novel mechanisms relating to cellular inflammation have been uncovered including the role of the hematopoietic system, toll-like receptor activation, endoplasmic reticulum stress and very recently T-cell activation in obesity-induced insulin resistance. These discoveries have led us to rethink cellular nutrient sensing and its role in inflammation and metabolic disease. Despite burgeoning investigation in this field, there still remain a number of unanswered questions. This review that evolved from the 2009 Stock Conference summarizes current research and identifies the deficiencies in our understanding of this topic. The overall goal of this Stock Conference was to bring together leading investigators in the field of inflammation and obesity research in the hope of fostering new ideas, thus advancing the pursuit of novel therapeutic strategies to reduce disease risk and or better treat chronic disease including type 2 diabetes, cardiovascular disease and cancer.

  13. Metabolic adaptation to tissue iron overload confers tolerance to malaria.

    PubMed

    Gozzelino, Raffaella; Andrade, Bruno Bezerril; Larsen, Rasmus; Luz, Nivea F; Vanoaica, Liviu; Seixas, Elsa; Coutinho, Antonio; Cardoso, Sílvia; Rebelo, Sofia; Poli, Maura; Barral-Netto, Manoel; Darshan, Deepak; Kühn, Lukas C; Soares, Miguel P

    2012-11-15

    Disease tolerance is a defense strategy that limits the fitness costs of infection irrespectively of pathogen burden. While restricting iron (Fe) availability to pathogens is perceived as a host defense strategy, the resulting tissue Fe overload can be cytotoxic and promote tissue damage to exacerbate disease severity. Examining this interplay during malaria, the disease caused by Plasmodium infection, we find that expression of the Fe sequestering protein ferritin H chain (FtH) in mice, and ferritin in humans, is associated with reduced tissue damage irrespectively of pathogen burden. FtH protection relies on its ferroxidase activity, which prevents labile Fe from sustaining proapoptotic c-Jun N-terminal kinase (JNK) activation. FtH expression is inhibited by JNK activation, promoting tissue Fe overload, tissue damage, and malaria severity. Mimicking FtH's antioxidant effect or inhibiting JNK activation pharmacologically confers therapeutic tolerance to malaria in mice. Thus, FtH provides metabolic adaptation to tissue Fe overload, conferring tolerance to malaria.

  14. 2009 Plant Lipids: Structure, Metabolism & Function Gordon Research Conference - February 1- 6 ,2009

    SciTech Connect

    Kent D. Chapman

    2009-02-06

    The Gordon Research Conference on 'Plant Lipids: Structure, Metabolism and Function' has been instituted to accelerate research productivity in the field of plant lipids. This conference will facilitate wide dissemination of research breakthroughs, support recruitment of young scientists to the field of plant lipid metabolism and encourage broad participation of the plant lipid community in guiding future directions for research in plant lipids. This conference will build upon the strengths of the successful, previous biannual meetings of the National Plant Lipid Cooperative (www.plantlipids.org) that began in 1993, but will reflect a broader scope of topics to include the biochemistry, cell biology, metabolic regulation, and signaling functions of plant acyl lipids. Most importantly, this conference also will serve as a physical focal point for the interaction of the plant lipid research community. Applications to attend this conference will be open to all researchers interested in plant lipids and will provide a venue for the presentation of the latest research results, networking opportunities for young scientists, and a forum for the development and exchange of useful lipid resources and new ideas. By bringing together senior- and junior-level scientists involved in plant lipid metabolism, a broad range of insights will be shared and the community of plant lipid researchers will function more as a network of vested partners. This is important for the vitality of the research community and for the perceived value that will encourage conference attendance into the future.

  15. 2005 Plant Metabolic Engineering Gordon Conference - July 10-15, 2005

    SciTech Connect

    Eleanore T. Wurtzel

    2006-06-30

    The post-genomic era presents new opportunities for manipulating plant chemistry for improvement of plant traits such as disease and stress resistance and nutritional qualities. This conference will provide a setting for developing multidisciplinary collaborations needed to unravel the dynamic complexity of plant metabolic networks and advance basic and applied research in plant metabolic engineering. The conference will integrate recent advances in genomics, with metabolite and gene expression analyses. Research discussions will explore how biosynthetic pathways interact with regard to substrate competition and channeling, plasticity of biosynthetic enzymes, and investigate the localization, structure, and assembly of biosynthetic metabolons in native and nonnative environments. The meeting will develop new perspectives for plant transgenic research with regard to how transgene expression may influence cellular metabolism. Incorporation of spectroscopic approaches for metabolic profiling and flux analysis combined with mathematical modeling will contribute to the development of rational metabolic engineering strategies and lead to the development of new tools to assess temporal and subcellular changes in metabolite pools. The conference will also highlight new technologies for pathway engineering, including use of heterologous systems, directed enzyme evolution, engineering of transcription factors and application of molecular/genetic techniques for controlling biosynthetic pathways.

  16. 2001 Gordon Research Conference on Archaea: Ecology [sic], Metabolism. Final progress report [agenda and attendee list

    SciTech Connect

    Daniels, Charles

    2001-08-10

    The Gordon Research Conference on Archaea: Ecology, Metabolism [and Molecular Biology] was held at Proctor Academy, Andover, New Hampshire, August 5-10, 2001. The conference was attended by 135 participants. The attendees represented the spectrum of endeavor in this field, coming from academia, industry, and government laboratories, and included US and foreign scientists, senior researchers, young investigators, and students. Emphasis was placed on current unpublished research and discussion of the future target areas in this field. There was a conscious effort to stimulate discussion about the key issues in the field today. Session topics included the following: Ecology and genetic elements; Genomics and evolution; Ecology, genomes and gene regulation; Replication and recombination; Chromatin and transcription; Gene regulation; Post-transcription processing; Biochemistry and metabolism; Proteomics and protein structure; Metabolism and physiology. The featured speaker addressed the topic: ''Archaeal viruses, witnesses of prebiotic evolution?''

  17. Acetate Kinase Isozymes Confer Robustness in Acetate Metabolism

    PubMed Central

    Chan, Siu Hung Joshua; Nørregaard, Lasse; Solem, Christian; Jensen, Peter Ruhdal

    2014-01-01

    Acetate kinase (ACK) (EC no: 2.7.2.1) interconverts acetyl-phosphate and acetate to either catabolize or synthesize acetyl-CoA dependent on the metabolic requirement. Among all ACK entries available in UniProt, we found that around 45% are multiple ACKs in some organisms including more than 300 species but surprisingly, little work has been done to clarify whether this has any significance. In an attempt to gain further insight we have studied the two ACKs (AckA1, AckA2) encoded by two neighboring genes conserved in Lactococcus lactis (L. lactis) by analyzing protein sequences, characterizing transcription structure, determining enzyme characteristics and effect on growth physiology. The results show that the two ACKs are most likely individually transcribed. AckA1 has a much higher turnover number and AckA2 has a much higher affinity for acetate in vitro. Consistently, growth experiments of mutant strains reveal that AckA1 has a higher capacity for acetate production which allows faster growth in an environment with high acetate concentration. Meanwhile, AckA2 is important for fast acetate-dependent growth at low concentration of acetate. The results demonstrate that the two ACKs have complementary physiological roles in L. lactis to maintain a robust acetate metabolism for fast growth at different extracellular acetate concentrations. The existence of ACK isozymes may reflect a common evolutionary strategy in bacteria in an environment with varying concentrations of acetate. PMID:24638105

  18. 2012 Molecular Basis of Microbial One-Carbon Metabolism Gordon Research Conferences and Gordon Research Seminar, August 4-10,2012

    SciTech Connect

    Hanson, Thomas

    2012-08-10

    The 2012 Gordon Conference will present and discuss cutting-edge research in the field of microbial metabolism of C1 compounds. The conference will feature the roles and application of C1 metabolism in natural and synthetic systems at scales from molecules to ecosystems. The conference will stress molecular aspects of the unique metabolism exhibited by autotrophic bacteria, methanogens, methylotrophs, aerobic and anaerobic methanotrophs, and acetogens.

  19. 2004 Molecular Basis of Microbial One-Carbon Metabolism Gordon Conference - August 1-6, 2004

    SciTech Connect

    Joseph A. Krzycki

    2005-09-15

    The Gordon Research Conference (GRC) on 2004 Molecular Basis of Microbial One-Carbon Metabolism Gordon Conference - August 1-6, 2004 was held at Mount Holyoke College, South Hadley, MA from August 1-6, 2004. The Conference was well-attended with 117 participants (attendees list attached). The attendees represented the spectrum of endeavor in this field coming from academia, industry, and government laboratories, both U.S. and foreign scientists, senior researchers, young investigators, and students. In designing the formal speakers program, emphasis was placed on current unpublished research and discussion of the future target areas in this field. There was a conscious effort to stimulate lively discussion about the key issues in the field today. Time for formal presentations was limited in the interest of group discussions. In order that more scientists could communicate their most recent results, poster presentation time was scheduled. Attached is a copy of the formal schedule and speaker program and the poster program. In addition to these formal interactions, 'free time' was scheduled to allow informal discussions. Such discussions are fostering new collaborations and joint efforts in the field.

  20. Metabolically healthy and unhealthy obese – the 2013 Stock Conference report

    PubMed Central

    Samocha-Bonet, D.; Dixit, V. D.; Kahn, C. R.; Leibel, R. L.; Lin, X.; Nieuwdorp, M.; Pietiläinen, K. H.; Rabasa-Lhoret, R.; Roden, M.; Scherer, P. E.; Klein, S.; Ravussin, E.

    2015-01-01

    Summary Obesity is closely associated with cardiovascular diseases and type 2 diabetes, but some obese individuals, despite having excessive body fat, exhibit metabolic health that is comparable with that of lean individuals. The ‘healthy obese’ phenotype was described in the 1980s, but major advancements in its characterization were only made in the past five years. During this time, several new mechanisms that may be involved in health preservation in obesity were proposed through the use of transgenic animal models, use of sophisticated imaging techniques and in vivo measurements of insulin sensitivity. However, the main obstacle in advancing our understanding of the metabolically healthy obese phenotype and its related long-term health risks is the lack of a standardized definition. Here, we summarize the proceedings of the 13th Stock Conference of the International Association of the Study of Obesity. We describe the current research and highlight the unanswered questions and gaps in the field. Better understanding of metabolic health in obesity will assist in therapeutic decision-making and help identify therapeutic targets to improve metabolic health in obesity. PMID:25059108

  1. Metabolically healthy and unhealthy obese--the 2013 Stock Conference report.

    PubMed

    Samocha-Bonet, D; Dixit, V D; Kahn, C R; Leibel, R L; Lin, X; Nieuwdorp, M; Pietiläinen, K H; Rabasa-Lhoret, R; Roden, M; Scherer, P E; Klein, S; Ravussin, E

    2014-09-01

    Obesity is closely associated with cardiovascular diseases and type 2 diabetes, but some obese individuals, despite having excessive body fat, exhibit metabolic health that is comparable with that of lean individuals. The 'healthy obese' phenotype was described in the 1980s, but major advancements in its characterization were only made in the past five years. During this time, several new mechanisms that may be involved in health preservation in obesity were proposed through the use of transgenic animal models, use of sophisticated imaging techniques and in vivo measurements of insulin sensitivity. However, the main obstacle in advancing our understanding of the metabolically healthy obese phenotype and its related long-term health risks is the lack of a standardized definition. Here, we summarize the proceedings of the 13th Stock Conference of the International Association of the Study of Obesity. We describe the current research and highlight the unanswered questions and gaps in the field. Better understanding of metabolic health in obesity will assist in therapeutic decision-making and help identify therapeutic targets to improve metabolic health in obesity.

  2. Metabolic and target-site mechanisms combine to confer strong DDT resistance in Anopheles gambiae.

    PubMed

    Mitchell, Sara N; Rigden, Daniel J; Dowd, Andrew J; Lu, Fang; Wilding, Craig S; Weetman, David; Dadzie, Samuel; Jenkins, Adam M; Regna, Kimberly; Boko, Pelagie; Djogbenou, Luc; Muskavitch, Marc A T; Ranson, Hilary; Paine, Mark J I; Mayans, Olga; Donnelly, Martin J

    2014-01-01

    The development of resistance to insecticides has become a classic exemplar of evolution occurring within human time scales. In this study we demonstrate how resistance to DDT in the major African malaria vector Anopheles gambiae is a result of both target-site resistance mechanisms that have introgressed between incipient species (the M- and S-molecular forms) and allelic variants in a DDT-detoxifying enzyme. Sequencing of the detoxification enzyme, Gste2, from DDT resistant and susceptible strains of An. gambiae, revealed a non-synonymous polymorphism (I114T), proximal to the DDT binding domain, which segregated with strain phenotype. Recombinant protein expression and DDT metabolism analysis revealed that the proteins from the susceptible strain lost activity at higher DDT concentrations, characteristic of substrate inhibition. The effect of I114T on GSTE2 protein structure was explored through X-ray crystallography. The amino acid exchange in the DDT-resistant strain introduced a hydroxyl group nearby the hydrophobic DDT-binding region. The exchange does not result in structural alterations but is predicted to facilitate local dynamics and enzyme activity. Expression of both wild-type and 114T alleles the allele in Drosophila conferred an increase in DDT tolerance. The 114T mutation was significantly associated with DDT resistance in wild caught M-form populations and acts in concert with target-site mutations in the voltage gated sodium channel (Vgsc-1575Y and Vgsc-1014F) to confer extreme levels of DDT resistance in wild caught An. gambiae.

  3. A discrete genetic locus confers xyloglucan metabolism in select human gut Bacteroidetes

    PubMed Central

    Larsbrink, Johan; Rogers, Theresa E.; Hemsworth, Glyn R.; McKee, Lauren S.; Tauzin, Alexandra S.; Spadiut, Oliver; Klinter, Stefan; Pudlo, Nicholas A.; Urs, Karthik; Koropatkin, Nicole M.; Creagh, A. Louise; Haynes, Charles A.; Kelly, Amelia G.; Cederholm, Stefan Nilsson; Davies, Gideon J.; Martens, Eric C.; Brumer, Harry

    2014-01-01

    A well-balanced human diet includes a significant intake of non-starch polysaccharides, collectively termed “dietary fibre,” from the cell walls of diverse fruits and vegetables.1 Due to a paucity of alimentary enzymes encoded by the human genome,2 our ability to derive energy from dietary fibre depends on saccharification and fermentation of complex carbohydrates by the massive microbial community residing in our distal gut.3,4 The xyloglucans (XyGs), in particular, are a ubiquitous family of highly branched plant cell wall polysaccharides5,6 whose mechanism(s) of degradation in the human gut and consequent importance in nutrition was heretofore unknown.1,7,8 Here, we demonstrate that a single, complex gene locus in Bacteroides ovatus confers xyloglucan catabolism in this common colonic symbiont. Through targeted gene disruption, biochemical analysis of all predicted glycoside hydrolases and carbohydrate-binding proteins, and three-dimensional structural determination of the vanguard endo-xyloglucanase, we reveal the molecular mechanisms through which XyGs are hydrolysed to component monosaccharides for further metabolism. We also observe that orthologous xyloglucan utilization loci (XyGULs) serve as genetic markers of xyloglucan catabolism in Bacteroidetes, that XyGULs are restricted to a limited number of phylogenetically diverse strains, and that XyGULs are ubiquitous in surveyed human metagenomes. Our findings reveal that the metabolism of even highly abundant components of dietary fibre may be mediated by niche species, which has immediate fundamental and practical implications for gut symbiont population ecology in the context of human diet, nutrition and health.9–12 PMID:24463512

  4. A discrete genetic locus confers xyloglucan metabolism in select human gut Bacteroidetes.

    PubMed

    Larsbrink, Johan; Rogers, Theresa E; Hemsworth, Glyn R; McKee, Lauren S; Tauzin, Alexandra S; Spadiut, Oliver; Klinter, Stefan; Pudlo, Nicholas A; Urs, Karthik; Koropatkin, Nicole M; Creagh, A Louise; Haynes, Charles A; Kelly, Amelia G; Cederholm, Stefan Nilsson; Davies, Gideon J; Martens, Eric C; Brumer, Harry

    2014-02-27

    A well-balanced human diet includes a significant intake of non-starch polysaccharides, collectively termed 'dietary fibre', from the cell walls of diverse fruits and vegetables. Owing to the paucity of alimentary enzymes encoded by the human genome, our ability to derive energy from dietary fibre depends on the saccharification and fermentation of complex carbohydrates by the massive microbial community residing in our distal gut. The xyloglucans (XyGs) are a ubiquitous family of highly branched plant cell wall polysaccharides whose mechanism(s) of degradation in the human gut and consequent importance in nutrition have been unclear. Here we demonstrate that a single, complex gene locus in Bacteroides ovatus confers XyG catabolism in this common colonic symbiont. Through targeted gene disruption, biochemical analysis of all predicted glycoside hydrolases and carbohydrate-binding proteins, and three-dimensional structural determination of the vanguard endo-xyloglucanase, we reveal the molecular mechanisms through which XyGs are hydrolysed to component monosaccharides for further metabolism. We also observe that orthologous XyG utilization loci (XyGULs) serve as genetic markers of XyG catabolism in Bacteroidetes, that XyGULs are restricted to a limited number of phylogenetically diverse strains, and that XyGULs are ubiquitous in surveyed human metagenomes. Our findings reveal that the metabolism of even highly abundant components of dietary fibre may be mediated by niche species, which has immediate fundamental and practical implications for gut symbiont population ecology in the context of human diet, nutrition and health.

  5. MED13-dependent signaling from the heart confers leanness by enhancing metabolism in adipose tissue and liver

    PubMed Central

    Baskin, Kedryn K; Grueter, Chad E; Kusminski, Christine M; Holland, William L; Bookout, Angie L; Satapati, Santosh; Kong, Y Megan; Burgess, Shawn C; Malloy, Craig R; Scherer, Philipp E; Newgard, Christopher B; Bassel-Duby, Rhonda; Olson, Eric N

    2014-01-01

    The heart requires a continuous supply of energy but has little capacity for energy storage and thus relies on exogenous metabolic sources. We previously showed that cardiac MED13 modulates systemic energy homeostasis in mice. Here, we sought to define the extra-cardiac tissue(s) that respond to cardiac MED13 signaling. We show that cardiac overexpression of MED13 in transgenic (MED13cTg) mice confers a lean phenotype that is associated with increased lipid uptake, beta-oxidation and mitochondrial content in white adipose tissue (WAT) and liver. Cardiac expression of MED13 decreases metabolic gene expression in the heart but enhances them in WAT. Although exhibiting increased energy expenditure in the fed state, MED13cTg mice metabolically adapt to fasting. Furthermore, MED13cTg hearts oxidize fuel that is readily available, rendering them more efficient in the fed state. Parabiosis experiments in which circulations of wild-type and MED13cTg mice are joined, reveal that circulating factor(s) in MED13cTg mice promote enhanced metabolism and leanness. These findings demonstrate that MED13 acts within the heart to promote systemic energy expenditure in extra-cardiac energy depots and point to an unexplored metabolic communication system between the heart and other tissues. See also: M Nakamura & J Sadoshima (December 2014) PMID:25422356

  6. MED13-dependent signaling from the heart confers leanness by enhancing metabolism in adipose tissue and liver.

    PubMed

    Baskin, Kedryn K; Grueter, Chad E; Kusminski, Christine M; Holland, William L; Bookout, Angie L; Satapati, Santosh; Kong, Y Megan; Burgess, Shawn C; Malloy, Craig R; Scherer, Philipp E; Newgard, Christopher B; Bassel-Duby, Rhonda; Olson, Eric N

    2014-12-01

    The heart requires a continuous supply of energy but has little capacity for energy storage and thus relies on exogenous metabolic sources. We previously showed that cardiac MED13 modulates systemic energy homeostasis in mice. Here, we sought to define the extra-cardiac tissue(s) that respond to cardiac MED13 signaling. We show that cardiac overexpression of MED13 in transgenic (MED13cTg) mice confers a lean phenotype that is associated with increased lipid uptake, beta-oxidation and mitochondrial content in white adipose tissue (WAT) and liver. Cardiac expression of MED13 decreases metabolic gene expression in the heart but enhances them in WAT. Although exhibiting increased energy expenditure in the fed state, MED13cTg mice metabolically adapt to fasting. Furthermore, MED13cTg hearts oxidize fuel that is readily available, rendering them more efficient in the fed state. Parabiosis experiments in which circulations of wild-type and MED13cTg mice are joined, reveal that circulating factor(s) in MED13cTg mice promote enhanced metabolism and leanness. These findings demonstrate that MED13 acts within the heart to promote systemic energy expenditure in extra-cardiac energy depots and point to an unexplored metabolic communication system between the heart and other tissues.

  7. Molecular Basis of Microbial One-Carbon Metabolism 2008 Gordon Research Conference (July 20-25, 2008)

    SciTech Connect

    Stephen W. Ragsdale

    2009-08-12

    One-carbon (C-1) compounds play a central role in microbial metabolism. C-1 compounds include methane, carbon monoxide, CO2, and methanol as well as coenzyme-bound one-carbon compounds (methyl-B12, CH3-H4folate, etc). Such compounds are of broad global importance because several C-1 compounds (e.g., CH4) are important energy sources, some (e.g., CO2 and CH4) are potent greenhouse gases, and others (e.g., CH2Cl2) are xenobiotics. They are central in pathways of energy metabolism and carbon fixation by microbes and many are of industrial interest. Research on the pathways of one-carbon metabolism has added greatly to our understanding of evolution, structural biology, enzyme mechanisms, gene regulation, ecology, and applied biology. The 2008 meeting will include recent important findings in the following areas: (a) genomics, metagenomics, and proteomic studies that have expanded our understanding of autotrophy and C-1 metabolism and the evolution of these pathways; (b) redox regulation of carbon cycles and the interrelationship between the carbon cycle and other biogeochemical cycles (sulfur, nitrogen, oxygen); (c) novel pathways for carbon assimilation; (d) biotechnology related to C-1 metabolism; (e) novel enzyme mechanisms including channeling of C-1 intermediates during metabolism; and (f) the relationship between metal homeostasis and the global carbon cycle. The conference has a diverse and gender-balanced slate of speakers and session leaders. The wide variety of disciplines brought to the study of C-1 metabolism make the field an excellent one in which to train young researchers.

  8. BAD-Dependent Regulation of Fuel Metabolism and KATP Channel Activity Confers Resistance to Epileptic Seizures

    PubMed Central

    Giménez-Cassina, Alfredo; Martínez-François, Juan Ramón; Fisher, Jill K.; Szlyk, Benjamin; Polak, Klaudia; Wiwczar, Jessica; Tanner, Geoffrey R.; Lutas, Andrew; Yellen, Gary; Danial, Nika N.

    2012-01-01

    Summary Neuronal excitation can be substantially modulated by alterations in metabolism, as evident from the anticonvulsant effect of diets that reduce glucose utilization and promote ketone body metabolism. We provide genetic evidence that BAD, a protein with dual functions in apoptosis and glucose metabolism, imparts reciprocal effects on metabolism of glucose and ketone bodies in brain cells. These effects involve phospho-regulation of BAD and are independent of its apoptotic function. BAD modifications that reduce glucose metabolism produce a marked increase in the activity of metabolically sensitive KATP channels in neurons, as well as resistance to behavioral and electrographic seizures in vivo. Seizure resistance is reversed by genetic ablation of the KATP channel, implicating the BAD-KATP axis in metabolic control of neuronal excitation and seizure responses. PMID:22632729

  9. A new and highly sensitive method of analyzing metabolic activity using FLIM (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Evers, Michael; Salma, Nunciada; Birngruber, Reginald; Evans, Conor L.; Manstein, Dieter

    2017-02-01

    Traditional assessments of cellular metabolism are often destructive, time consuming and without visual information. Fluorescence lifetime imaging microscopy (FLIM) provides a highly sensitive, non-invasive, and label-free alternative. This study uses FLIM in combination with two-photon microscopy to investigate pharmacological induced metabolic changes of adipocytes via changes in the fluorescence of the metabolic co-factors NADH and FAD. In agreement with recent publications NADH fluorescence suggests the presence of four distinct lifetimes in cell culture and tissue with two unbound and two protein bound states which show different responses to treatment with metabolic modifiers. We evaluated the effects on NADH fluorescence lifetime after systematic manipulations to change the balance between oxidative and glycolytic metabolism using five pharmacological reagents - Oligomycin, 2-DG, FCCP, Rotenone, and Glucose - which interact with different parts of the metabolic pathway. We established several ratios between the four distinct lifetimes of NADH after treatment and compared the results to oxygen consumption rate and extracellular acidification rate. We demonstrated, for the first time, a correlation between the two unbound fluorescence lifetimes components and glycolytic and oxidative metabolic activity with a significant higher sensitivity compared to the commonly used free-to-bound ratio of NADH. Analyzing all four lifetime components of NADH has the potential to become a powerful tool to evaluate metabolic activity of adipocytes with subcellular resolution.

  10. Expression of slow skeletal TnI in adult mouse hearts confers metabolic protection to ischemia

    PubMed Central

    Pound, Kayla M.; Arteaga, Grace M.; Fasano, Mathew; Wilder, Tanganyika; Fischer, Susan K.; Warren, Chad M.; Wende, Adam R.; Farjah, Mariam; Abel, E. Dale; Solaro, R. John; Lewandowski, E. Douglas

    2011-01-01

    Changes in metabolic and myofilament phenotypes coincide in developing hearts. Posttranslational modification of sarcomere proteins influences contractility, affecting the energetic cost of contraction. However, metabolic adaptations to sarcomeric phenotypes are not well understood, particularly during pathophysiological stress. This study explored metabolic adaptations to expression of the fetal, slow skeletal muscle troponin I (ssTnI). Hearts expressing ssTnI exhibited no significant ATP loss during 5 minutes of global ischemia, while non-transgenic littermates (NTG) showed continual ATP loss. At 7 min ischemia TG-ssTnI hearts retained 80±12% of ATP vs. 49±6% in NTG (P<0.05). Hearts expressing ssTnI also had increased AMPK phosphorylation. The mechanism of ATP preservation was augmented glycolysis. Glycolytic end products (lactate and alanine) were 38% higher in TG-ssTnI than NTG at 2 min and 27% higher at 5 min. This additional glycolysis was supported exclusively by exogenous glucose, and not glycogen. Thus, expression of a fetal myofilament protein in adult mouse hearts induced elevated anaerobic ATP production during ischemia via metabolic adaptations consistent with the resistance to hypoxia of fetal hearts. The general findings hold important relevance to both our current understanding of the association between metabolic and contractile phenotypes and the potential for invoking cardioprotective mechanisms against ischemic stress. PMID:21640727

  11. Genomics:GTL Contractor-Grantee Workshop IV and Metabolic Engineering Working Group Inter-Agency Conference on Metabolic Engineering 2006

    SciTech Connect

    Mansfield, Betty Kay; Martin, Sheryl A

    2006-02-01

    Welcome to the 2006 joint meeting of the fourth Genomics:GTL Contractor-Grantee Workshop and the six Metabolic Engineering Working Group Inter-Agency Conference. The vision and scope of the Genomics:GTL program continue to expand and encompass research and technology issues from diverse scientific disciplines, attracting broad interest and support from researchers at universities, DOE national laboratories, and industry. Metabolic engineering's vision is the targeted and purposeful alteration of metabolic pathways to improve the understanding and use of cellular pathways for chemical transformation, energy transduction, and supramolecular assembly. These two programs have much complementarity in both vision and technological approaches, as reflected in this joint workshop. GLT's challenge to the scientific community remains the further development and use of a broad array of innovative technologies and computational tools to systematically leverage the knowledge and capabilities brought to us by DNA sequencing projects. The goal is to seek a broad and predictive understanding of the functioning and control of complex systems--individual microbes, microbial communities, and plants. GTL's prominent position at the interface of the physical, computational, and biological sciences is both a strength and challenge. Microbes remain GTL's principal biological focus. In the complex 'simplicity' of microbes, they find capabilities needed by DOE and the nation for clean and secure energy, cleanup of environmental contamination, and sequestration of atmospheric carbon dioxide that contributes to global warming. An ongoing challenge for the entire GTL community is to demonstrate that the fundamental science conducted in each of your research projects brings us a step closer to biology-based solutions for these important national energy and environmental needs.

  12. Aberrant lipogenesis is a metabolic marker for azole-resistant candida albicans (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Karanja, Caroline; Hong, Weili; Younis, Waleed; Cheng, Ji-Xin; Seleem, Mohamed

    2017-02-01

    Candida is the single most important cause of fungal bloodstream infections worldwide causing significant mortality as high as 50%. This high mortality rate is, in part, due to the inability to rapidly diagnose and simultaneously initiate an effective antifungal therapy early in the disease process. Current culture-based diagnostics are often slow, requiring several days to complete, and are only 50% sensitive in diagnosing candidemia (Candida bloodstream infection). For every 12 hours of delay in starting correct antifungal therapy, the risk of death for a given patient with candidemia increases by 200%. To address this unmet need, we explored the potential of employing stimulated Raman Scattering (SRS) imaging to diagnose candidemia and probe metabolic differences between resistant and susceptible strain at a single cell level. Metabolism is integral to pathogenicity; microorganism have very short life cycles, and therefore only a few hours are needed to observe a full metabolic cycle. SRS imaging at C-H vibration frequency at 2850 cm-1 revealed a substantial difference in lipogenesis between the susceptible and resistant C. albicans. Treating the C. albicans with fluconazole, an antimicrobial drug that targets ergosterol biosynthesis only affected the lipogenesis in the susceptible strain. Our results show that single-cell metabolic imaging under a SRS microscope can be used for diagnose candidemia and early detection of antimicrobial susceptibility.

  13. Dynamic full field OCT: metabolic contrast at subcellular level (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Apelian, Clement; Harms, Fabrice; Thouvenin, Olivier; Boccara, Claude A.

    2016-03-01

    Cells shape or density is an important marker of tissues pathology. However, individual cells are difficult to observe in thick tissues frequently presenting highly scattering structures such as collagen fibers. Endogenous techniques struggle to image cells in these conditions. Moreover, exogenous contrast agents like dyes, fluorophores or nanoparticles cannot always be used, especially if non-invasive imaging is required. Scatterers motion happening down to the millisecond scale, much faster than the still and highly scattering structures (global motion of the tissue), allowed us to develop a new approach based on the time dependence of the FF-OCT signals. This method reveals hidden cells after a spatiotemporal analysis based on singular value decomposition and wavelet analysis concepts. It does also give us access to local dynamics of imaged scatterers. This dynamic information is linked with the local metabolic activity that drives these scatterers. Our technique can explore subcellular scales with micrometric resolution and dynamics ranging from the millisecond to seconds. By this mean we studied a wide range of tissues, animal and human in both normal and pathological conditions (cancer, ischemia, osmotic shock…) in different organs such as liver, kidney, and brain among others. Different cells, undetectable with FF-OCT, were identified (erythrocytes, hepatocytes…). Different scatterers clusters express different characteristic times and thus can be related to different mechanisms that we identify with metabolic functions. We are confident that the D-FFOCT, by accessing to a new spatiotemporal metabolic contrast, will be a leading technique on tissue imaging and for better medical diagnosis.

  14. Flexibility in metabolic rate confers a growth advantage under changing food availability

    PubMed Central

    Auer, Sonya K; Salin, Karine; Rudolf, Agata M; Anderson, Graeme J; Metcalfe, Neil B; Ardia, Daniel

    2015-01-01

    Phenotypic flexibility in physiological, morphological and behavioural traits can allow organisms to cope with environmental challenges. Given recent climate change and the degree of habitat modification currently experienced by many organisms, it is therefore critical to quantify the degree of phenotypic variation present within populations, individual capacities to change and what their consequences are for fitness. Flexibility in standard metabolic rate (SMR) may be particularly important since SMR reflects the minimal energetic cost of living and is one of the primary traits underlying organismal performance. SMR can increase or decrease in response to food availability, but the consequences of these changes for growth rates and other fitness components are not well known. We examined individual variation in metabolic flexibility in response to changing food levels and its consequences for somatic growth in juvenile brown trout (Salmo trutta). SMR increased when individuals were switched to a high food ration and decreased when they were switched to a low food regime. These shifts in SMR, in turn, were linked with individual differences in somatic growth; those individuals that increased their SMR more in response to elevated food levels grew fastest, while growth at the low food level was fastest in those individuals that depressed their SMR most. Flexibility in energy metabolism is therefore a key mechanism to maximize growth rates under the challenges imposed by variability in food availability and is likely to be an important determinant of species’ resilience in the face of global change. PMID:25939669

  15. Flexibility in metabolic rate confers a growth advantage under changing food availability.

    PubMed

    Auer, Sonya K; Salin, Karine; Rudolf, Agata M; Anderson, Graeme J; Metcalfe, Neil B

    2015-09-01

    1. Phenotypic flexibility in physiological, morphological and behavioural traits can allow organisms to cope with environmental challenges. Given recent climate change and the degree of habitat modification currently experienced by many organisms, it is therefore critical to quantify the degree of phenotypic variation present within populations, individual capacities to change and what their consequences are for fitness. 2. Flexibility in standard metabolic rate (SMR) may be particularly important since SMR reflects the minimal energetic cost of living and is one of the primary traits underlying organismal performance. SMR can increase or decrease in response to food availability, but the consequences of these changes for growth rates and other fitness components are not well known. 3. We examined individual variation in metabolic flexibility in response to changing food levels and its consequences for somatic growth in juvenile brown trout (Salmo trutta). 4. SMR increased when individuals were switched to a high food ration and decreased when they were switched to a low food regime. These shifts in SMR, in turn, were linked with individual differences in somatic growth; those individuals that increased their SMR more in response to elevated food levels grew fastest, while growth at the low food level was fastest in those individuals that depressed their SMR most. 5. Flexibility in energy metabolism is therefore a key mechanism to maximize growth rates under the challenges imposed by variability in food availability and is likely to be an important determinant of species' resilience in the face of global change.

  16. High-throughput autofluorescence flow cytometry of breast cancer metabolism (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Shah, Amy T.; Cannon, Taylor M.; Higginbotham, Jim N.; Skala, Melissa C.

    2016-02-01

    Tumor heterogeneity poses challenges for devising optimal treatment regimens for cancer patients. In particular, subpopulations of cells can escape treatment and cause relapse. There is a need for methods to characterize tumor heterogeneity of treatment response. Cell metabolism is altered in cancer (Warburg effect), and cells use the autofluorescent cofactor NADH in numerous metabolic reactions. Previous studies have shown that microscopy measurements of NADH autofluorescence are sensitive to treatment response in breast cancer, and these techniques typically assess hundreds of cells per group. An alternative approach is flow cytometry, which measures fluorescence on a single-cell level and is attractive for characterizing tumor heterogeneity because it achieves high-throughput analysis and cell sorting in millions of cells per group. Current applications for flow cytometry rely on staining with fluorophores. This study characterizes flow cytometry measurements of NADH autofluorescence in breast cancer cells. Preliminary results indicate flow cytometry of NADH is sensitive to cyanide perturbation, which inhibits oxidative phosphorylation, in nonmalignant MCF10A cells. Additionally, flow cytometry is sensitive to higher NADH intensity for HER2-positive SKBr3 cells compared with triple-negative MDA-MB-231 cells. These results agree with previous microscopy studies. Finally, a mixture of SKBr3 and MDA-MB-231 cells were sorted into each cell type using NADH intensity. Sorted cells were cultured, and microscopy validation showed the expected morphology for each cell type. Ultimately, flow cytometry could be applied to characterize tumor heterogeneity based on treatment response and sort cell subpopulations based on metabolic profile. These achievements could enable individualized treatment strategies and improved patient outcomes.

  17. Subcellular metabolic contrast in living tissue using dynamic full field OCT (D-FFOCT) (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Apelian, Clement; Harms, Fabrice; Thouvenin, Olivier; Boccara, Claude A.

    2016-03-01

    Cells shape or density is an important marker of tissues pathology. However, individual cells are difficult to observe in thick tissues frequently presenting highly scattering structures such as collagen fibers. Endogenous techniques struggle to image cells in these conditions. Moreover, exogenous contrast agents like dyes, fluorophores or nanoparticles cannot always be used, especially if non-invasive imaging is required. Scatterers motion happening down to the millisecond scale, much faster than the fix and highly scattering structures (global motion of the tissue), allowed us to develop a new approach based on the time dependence of the FF-OCT signals. This method reveals hidden cells after a spatiotemporal analysis based on singular value decomposition and wavelet analysis concepts. It does also give us access to local dynamics of imaged scatterers. This dynamic information is linked with the local metabolic activity that drives these scatterers. Our technique can explore subcellular scales with micrometric resolution and dynamics ranging from the millisecond to seconds. By this mean we studied a wide range of tissues, animal and human in both normal and pathological conditions (cancer, ischemia, osmotic shock…) in different organs such as liver, kidney, and brain among others. Different cells, undetectable with FF-OCT, were identified (erythrocytes, hepatocytes…). Different scatterer clusters express different characteristic times and thus can be related to different mechanisms that we identify with metabolic functions. We are confident that the D-FFOCT, by accessing to a new spatiotemporal metabolic contrast, will be a leading technique on tissue imaging and could lead to better medical diagnosis.

  18. Optical metabolic imaging measures early drug response in an allograft murine breast cancer model (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Sharick, Joe T.; Cook, Rebecca S.; Skala, Melissa C.

    2017-02-01

    Previous work has shown that cellular-level Optical Metabolic Imaging (OMI) of organoids derived from human breast cancer cell-line xenografts accurately and rapidly predicts in vivo response to therapy. To validate OMI as a predictive measure of treatment response in an immune-competent model, we used the polyomavirus middle-T (PyVmT) transgenic mouse breast cancer model. The PyVmT model includes intra-tumoral heterogeneity and a complex tumor microenvironment that can influence treatment responses. Three-dimensional organoids generated from primary PyVmT tumor tissue were treated with a chemotherapy (paclitaxel) and a PI3K inhibitor (XL147), each alone or in combination. Cellular subpopulations of response were measured using the OMI Index, a composite endpoint of metabolic response comprised of the optical redox ratio (ratio of the fluorescence intensities of metabolic co-enzymes NAD(P)H to FAD) as well as the fluorescence lifetimes of NAD(P)H and FAD. Combination treatment significantly decreased the OMI Index of PyVmT tumor organoids (p<0.0001) and in vivo tumors (p<0.0001) versus controls. Subpopulation analyses revealed a homogeneous response to combined therapy in both cultured organoids and in vivo tumors, while single agent treatment with XL147 alone or paclitaxel alone elicited heterogeneous responses in organoids. Tumor volume decreased with combination treatment through treatment day 30. These results indicate that OMI of organoids generated from PyVmT tumors can accurately reflect drug response in heterogeneous allografts with both innate and adaptive immunity. Thus, this method is promising for use in humans to predict long-term treatment responses accurately and rapidly, and could aid in clinical treatment planning.

  19. Structural dissection of a complex Bacteroides ovatus gene locus conferring xyloglucan metabolism in the human gut

    PubMed Central

    Thompson, Andrew J.; Stepper, Judith; Sobala, Łukasz F.; Coyle, Travis; Larsbrink, Johan; Spadiut, Oliver; Goddard-Borger, Ethan D.; Stubbs, Keith A.; Brumer, Harry; Davies, Gideon J.

    2016-01-01

    The human gastrointestinal tract harbours myriad bacterial species, collectively termed the microbiota, that strongly influence human health. Symbiotic members of our microbiota play a pivotal role in the digestion of complex carbohydrates that are otherwise recalcitrant to assimilation. Indeed, the intrinsic human polysaccharide-degrading enzyme repertoire is limited to various starch-based substrates; more complex polysaccharides demand microbial degradation. Select Bacteroidetes are responsible for the degradation of the ubiquitous vegetable xyloglucans (XyGs), through the concerted action of cohorts of enzymes and glycan-binding proteins encoded by specific xyloglucan utilization loci (XyGULs). Extending recent (meta)genomic, transcriptomic and biochemical analyses, significant questions remain regarding the structural biology of the molecular machinery required for XyG saccharification. Here, we reveal the three-dimensional structures of an α-xylosidase, a β-glucosidase, and two α-l-arabinofuranosidases from the Bacteroides ovatus XyGUL. Aided by bespoke ligand synthesis, our analyses highlight key adaptations in these enzymes that confer individual specificity for xyloglucan side chains and dictate concerted, stepwise disassembly of xyloglucan oligosaccharides. In harness with our recent structural characterization of the vanguard endo-xyloglucanse and cell-surface glycan-binding proteins, the present analysis provides a near-complete structural view of xyloglucan recognition and catalysis by XyGUL proteins. PMID:27466444

  20. Visible light optical coherence tomography measure retinal oxygen metabolic response to systemic oxygenation (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Yi, Ji; Liu, Wenzhong; Chen, Siyu; Backman, Vadim; Sheibani, Nader; Sorenson, Christine M.; Fawzi, Amani A.; Linsenmeier, Robert A.; Zhang, Hao F.

    2016-03-01

    The lack of capability to quantify oxygen metabolism noninvasively impedes both fundamental investigation and clinical diagnosis of a wide spectrum of diseases including all the major blinding diseases such as age-related macular degeneration, diabetic retinopathy, and glaucoma. Using visible light optical coherence tomography (vis-OCT), we demonstrated accurate and robust measurement of retinal oxygen metabolic rate (rMRO2) noninvasively in rat eyes. The rMRO2 was calculated by concurrent measurement of blood flow and blood oxygen saturation (sO2). Blood flow was calculated by the principle of Doppler optical coherence tomography, where the phase shift between two closely spaced A-lines measures the axial velocity. The distinct optical absorption spectra of oxy- and deoxy-hemoglobin provided the contrast for sO2 measurement, combined with the spectroscopic analysis of vis-OCT signal within the blood vessels. We continuously monitored the regulatory response of oxygen consumption to a progressive hypoxic challenge. We found that both oxygen delivery, and rMRO2 increased from the highly regulated retinal circulation (RC) under hypoxia, by 0.28+/-0.08 μL/min (p<0.001), and 0.20+/-0.04 μL/min (p<0.001) per 100 mmHg systemic pO2 reduction, respectively. The increased oxygen extraction compensated for the deficient oxygen supply from the poorly regulated choroidal circulation (CC).

  1. Adiponectin induces A20 expression in adipose tissue to confer metabolic benefit.

    PubMed

    Hand, Laura E; Usan, Paola; Cooper, Garth J S; Xu, Lance Y; Ammori, Basil; Cunningham, Peter S; Aghamohammadzadeh, Reza; Soran, Handrean; Greenstein, Adam; Loudon, Andrew S I; Bechtold, David A; Ray, David W

    2015-01-01

    Obesity is a major risk factor for metabolic disease, with white adipose tissue (WAT) inflammation emerging as a key underlying pathology. We detail that mice lacking Reverbα exhibit enhanced fat storage without the predicted increased WAT inflammation or loss of insulin sensitivity. In contrast to most animal models of obesity and obese human patients, Reverbα(-/-) mice exhibit elevated serum adiponectin levels and increased adiponectin secretion from WAT explants in vitro, highlighting a potential anti-inflammatory role of this adipokine in hypertrophic WAT. Indeed, adiponectin was found to suppress primary macrophage responses to lipopolysaccharide and proinflammatory fatty acids, and this suppression depended on glycogen synthase kinase 3β activation and induction of A20. Attenuated inflammatory responses in Reverbα(-/-) WAT depots were associated with tonic elevation of A20 protein and ex vivo shown to depend on A20. We also demonstrate that adipose A20 expression in obese human subjects exhibits a negative correlation with measures of insulin sensitivity. Furthermore, bariatric surgery-induced weight loss was accompanied by enhanced WAT A20 expression, which is positively correlated with increased serum adiponectin and improved metabolic and inflammatory markers, including C-reactive protein. The findings identify A20 as a mediator of adiponectin anti-inflammatory action in WAT and a potential target for mitigating obesity-related pathology.

  2. Folate cycle enzyme MTHFD1L confers metabolic advantages in hepatocellular carcinoma.

    PubMed

    Lee, Derek; Xu, Iris Ming-Jing; Chiu, David Kung-Chun; Lai, Robin Kit-Ho; Tse, Aki Pui-Wah; Lan Li, Lynna; Law, Cheuk-Ting; Tsang, Felice Ho-Ching; Wei, Larry Lai; Chan, Cerise Yuen-Ki; Wong, Chun-Ming; Ng, Irene Oi-Lin; Wong, Carmen Chak-Lui

    2017-04-10

    Cancer cells preferentially utilize glucose and glutamine, which provide macromolecules and antioxidants that sustain rapid cell division. Metabolic reprogramming in cancer drives an increased glycolytic rate that supports maximal production of these nutrients. The folate cycle, through transfer of a carbon unit between tetrahydrofolate and its derivatives in the cytoplasmic and mitochondrial compartments, produces other metabolites that are essential for cell growth, including nucleotides, methionine, and the antioxidant NADPH. Here, using hepatocellular carcinoma (HCC) as a cancer model, we have observed a reduction in growth rate upon withdrawal of folate. We found that an enzyme in the folate cycle, methylenetetrahydrofolate dehydrogenase 1-like (MTHFD1L), plays an essential role in support of cancer growth. We determined that MTHFD1L is transcriptionally activated by NRF2, a master regulator of redox homeostasis. Our observations further suggest that MTHFD1L contributes to the production and accumulation of NADPH to levels that are sufficient to combat oxidative stress in cancer cells. The elevation of oxidative stress through MTHFD1L knockdown or the use of methotrexate, an antifolate drug, sensitizes cancer cells to sorafenib, a targeted therapy for HCC. Taken together, our study identifies MTHFD1L in the folate cycle as an important metabolic pathway in cancer cells with the potential for therapeutic targeting.

  3. Visible-light OCT to quantify retinal oxygen metabolism (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Zhang, Hao F.; Yi, Ji; Chen, Siyu; Liu, Wenzhong; Soetikno, Brian T.

    2016-03-01

    We explored, both numerically and experimentally, whether OCT can be a good candidate to accurately measure retinal oxygen metabolism. We first used statistical methods to numerically simulate photon transport in the retina to mimic OCT working under different spectral ranges. Then we analyze accuracy of OCT oximetry subject to parameter variations such as vessel size, pigmentation, and oxygenation. We further developed an experimental OCT system based on the spectral range identified by our simulation work. We applied the newly developed OCT to measure both retinal hemoglobin oxygen saturation (sO2) and retinal retinal flow. After obtaining the retinal sO2 and blood velocity, we further measured retinal vessel diameter and calculated the retinal oxygen metabolism rate (MRO2). To test the capability of our OCT, we imaged wild-type Long-Evans rats ventilated with both normal air and air mixtures with various oxygen concentrations. Our simulation suggested that OCT working within visible spectral range is able to provide accurate measurement of retinal MRO2 using inverse Fourier transform spectral reconstruction. We called this newly developed technology vis-OCT, and showed that vis-OCT was able to measure the sO2 value in every single major retinal vessel around the optical disk as well as in micro retinal vessels. When breathing normal air, the averaged sO2 in arterial and venous blood in Long-Evans rats was measured to be 95% and 72%, respectively. When we challenge the rats using air mixtures with different oxygen concentrations, vis-OCT measurement followed analytical models of retinal oxygen diffusion and pulse oximeter well.

  4. Microenvironment mediated alterations to metabolic pathways confer increased chemo-resistance in CD133+ tumor initiating cells

    PubMed Central

    Nomura, Alice; Dauer, Patricia; Gupta, Vineet; McGinn, Olivia; Arora, Nivedita; Majumdar, Kaustav; III, Charles Uhlrich; Dalluge, Joseph; Dudeja, Vikas; Saluja, Ashok; Banerjee, Sulagna

    2016-01-01

    Chemoresistance in pancreatic cancer has been attributed to tumor-initiating cells (TICs), a minor sub-population of tumor cells. However, the mechanism of chemo-resistance in these cells is still unclear. In the current study, immunohistochemical analysis of LSL-KrasG12D; LSL-Trp53R172H; PdxCre (KPC) murine tumors indicated that hypoxic regions developed through tumor progression. This hypoxic “niche” correlated with increased CD133+ population that had an increased HIF1A activity. Consistent with this observation, CD133+ cells had increased glucose uptake and activity of glycolytic pathway enzymes compared to CD133− cells. Mass spectrometric analysis (UPLC-TQD) following metabolic labeling of CD133+ cells with [13C]-U6 glucose confirmed this observation. Furthermore, although both populations had functionally active mitochondria, CD133+ cells had low mitochondrial complex I and complex IV activity and lesser accumulation of ROS in response to standard chemotherapeutic compounds like paclitaxel, 5FU and gemcitabine. CD133+ cells also showed increased resistance to all three chemotherapeutic compounds and treatment with Glut1 inhibitor (STF31) reversed this resistance, promoting apoptotic death in these cells similar to CD133− cells. Our study indicates that the altered metabolic profile of CD133+ pancreatic TIC protects them against apoptosis, by reducing accumulation of ROS induced by standard chemotherapeutic agents, thereby confering chemoresistance. Since resistance to existing chemotherapy contributes to the poor prognosis in pancreatic cancer, our study paves the way for identifying novel therapeutic targets for managing chemoresistance and tumor recurrence in pancreatic cancer. PMID:27472388

  5. Metabolism by conjugation appears to confer resistance to paracetamol (acetaminophen) hepatotoxicity in the cynomolgus monkey.

    PubMed

    Yu, Hong; Barrass, Nigel; Gales, Sonya; Lenz, Eva; Parry, Tony; Powell, Helen; Thurman, Dale; Hutchison, Michael; Wilson, Ian D; Bi, Luke; Qiao, Junwen; Qin, Qiuping; Ren, Jin

    2015-03-01

    1. Paracetamol overdose remains the leading cause of acute liver failure in humans. This study was undertaken in cynomolgus monkeys to study the pharmacokinetics, metabolism and the potential for hepatotoxic insult from paracetamol administration as a possible model for human toxicity. 2. No adverse effects were observed for doses of up to 900 mg/kg/d for 14 d. Only minor sporadic increases in alanine aminotransferase, aspartate aminotransferase and glutamate dehydrogenase in a number of animals were observed, with no clear dose response. 3. Toxicokinetic analysis showed good plasma exposure, albeit with less than proportional rises in Cmax and AUC, with increasing dose. The Cmax values in monkey were up to 3.5 times those associated with human liver toxicity and the AUC approx. 1000 times those associated with liver enzyme changes in 31-44% of human subjects. 4. Metabolite profiling of urine by (1)H NMR spectroscopy revealed paracetamol and its glucuronide and sulphate metabolites. Glutathione-derived metabolites, e.g. the cysteinyl conjugate, were only present in very low concentrations whilst the mercapturate was not detected. 5. These in vivo observations demonstrated that the cynomolgus monkey is remarkably resistant to paracetamol-induced toxicity and a poor model for investigating paracetamol-related hepatotoxicity in humans.

  6. Plasmid-Encoded asp Operon Confers a Proton Motive Metabolic Cycle Catalyzed by an Aspartate-Alanine Exchange Reaction

    PubMed Central

    Abe, Keietsu; Ohnishi, Fumito; Yagi, Kyoko; Nakajima, Tasuku; Higuchi, Takeshi; Sano, Motoaki; Machida, Masayuki; Sarker, Rafiquel I.; Maloney, Peter C.

    2002-01-01

    Tetragenococcus halophila D10 catalyzes the decarboxylation of l-aspartate with nearly stoichiometric release of l-alanine and CO2. This trait is encoded on a 25-kb plasmid, pD1. We found in this plasmid a putative asp operon consisting of two genes, which we designated aspD and aspT, encoding an l-aspartate-β-decarboxylase (AspD) and an aspartate-alanine antiporter (AspT), respectively, and determined the nucleotide sequences. The sequence analysis revealed that the genes of the asp operon in pD1 were in the following order: promoter → aspD → aspT. The deduced amino acid sequence of AspD showed similarity to the sequences of two known l-aspartate-β-decarboxylases from Pseudomonas dacunhae and Alcaligenes faecalis. Hydropathy analyses suggested that the aspT gene product encodes a hydrophobic protein with multiple membrane-spanning regions. The operon was subcloned into the Escherichia coli expression vector pTrc99A, and the two genes were cotranscribed in the resulting plasmid, pTrcAsp. Expression of the asp operon in E. coli coincided with appearance of the capacity to catalyze the decarboxylation of aspartate to alanine. Histidine-tagged AspD (AspDHis) was also expressed in E. coli and purified from cell extracts. The purified AspDHis clearly exhibited activity of l-aspartate-β-decarboxylase. Recombinant AspT was solubilized from E. coli membranes and reconstituted in proteoliposomes. The reconstituted AspT catalyzed self-exchange of aspartate and electrogenic heterologous exchange of aspartate with alanine. Thus, the asp operon confers a proton motive metabolic cycle consisting of the electrogenic aspartate-alanine antiporter and the aspartate decarboxylase, which keeps intracellular levels of alanine, the countersubstrate for aspartate, high. PMID:12003930

  7. Plasmid-encoded asp operon confers a proton motive metabolic cycle catalyzed by an aspartate-alanine exchange reaction.

    PubMed

    Abe, Keietsu; Ohnishi, Fumito; Yagi, Kyoko; Nakajima, Tasuku; Higuchi, Takeshi; Sano, Motoaki; Machida, Masayuki; Sarker, Rafiquel I; Maloney, Peter C

    2002-06-01

    Tetragenococcus halophila D10 catalyzes the decarboxylation of L-aspartate with nearly stoichiometric release of L-alanine and CO(2). This trait is encoded on a 25-kb plasmid, pD1. We found in this plasmid a putative asp operon consisting of two genes, which we designated aspD and aspT, encoding an L-aspartate-beta-decarboxylase (AspD) and an aspartate-alanine antiporter (AspT), respectively, and determined the nucleotide sequences. The sequence analysis revealed that the genes of the asp operon in pD1 were in the following order: promoter --> aspD --> aspT. The deduced amino acid sequence of AspD showed similarity to the sequences of two known L-aspartate-beta-decarboxylases from Pseudomonas dacunhae and Alcaligenes faecalis. Hydropathy analyses suggested that the aspT gene product encodes a hydrophobic protein with multiple membrane-spanning regions. The operon was subcloned into the Escherichia coli expression vector pTrc99A, and the two genes were cotranscribed in the resulting plasmid, pTrcAsp. Expression of the asp operon in E. coli coincided with appearance of the capacity to catalyze the decarboxylation of aspartate to alanine. Histidine-tagged AspD (AspDHis) was also expressed in E. coli and purified from cell extracts. The purified AspDHis clearly exhibited activity of L-aspartate-beta-decarboxylase. Recombinant AspT was solubilized from E. coli membranes and reconstituted in proteoliposomes. The reconstituted AspT catalyzed self-exchange of aspartate and electrogenic heterologous exchange of aspartate with alanine. Thus, the asp operon confers a proton motive metabolic cycle consisting of the electrogenic aspartate-alanine antiporter and the aspartate decarboxylase, which keeps intracellular levels of alanine, the countersubstrate for aspartate, high.

  8. Metabolism

    MedlinePlus

    Metabolism refers to all the physical and chemical processes in the body that convert or use energy, ... Tortora GJ, Derrickson BH. Metabolism. In: Tortora GJ, Derrickson ... Physiology . 14th ed. Hoboken, NJ: John Wiley & Sons; 2014:chap ...

  9. Metabolism

    MedlinePlus

    ... El metabolismo Metabolism Basics Our bodies get the energy they need from food through metabolism, the chemical ... that convert the fuel from food into the energy needed to do everything from moving to thinking ...

  10. Metabolic bone diseases in patients after allogeneic hematopoietic stem cell transplantation: report from the Consensus Conference on Clinical Practice in chronic graft-versus-host disease.

    PubMed

    Hautmann, Anke Heidewig; Elad, Sharon; Lawitschka, Anita; Greinix, Hildegard; Bertz, Hartmut; Halter, Joerg; Faraci, Maura; Hofbauer, Lorenz Christian; Lee, Stephanie; Wolff, Daniel; Holler, Ernst

    2011-09-01

    With improved outcome of allogeneic stem cell transplantation (allo-SCT) for hematologic malignancies, long-term complications gain greater importance. Skeletal complications such as osteoporosis or avascular necrosis (AVN) occur frequently in allogeneic recipients with a cumulative incidence of diminished bone mineral density of 24-50% between 2 and 12 months after allo-SCT and a cumulative incidence of AVN in as many as 19% of patients 3 years after allo-SCT. Here, we present a review as part of the German, Austrian, and Swiss Consensus Conference on clinical practice in chronic graft-versus-host disease, held 2009 in Regensburg. The Consensus Conference aimed to achieve a consensus on the current evidence of diagnosis, prevention, and therapeutic options of late complications after allo-SCT summarizing and discussing the literature on these topics. In this report, we provide recommendations for metabolic bone diseases agreed upon by the working party. This includes guidelines for diagnosis, prevention, and therapeutic options in patients with low bone mass or AVN.

  11. Metabolic pathway engineering based on metabolomics confers acetic and formic acid tolerance to a recombinant xylose-fermenting strain of Saccharomyces cerevisiae

    PubMed Central

    2011-01-01

    Background The development of novel yeast strains with increased tolerance toward inhibitors in lignocellulosic hydrolysates is highly desirable for the production of bio-ethanol. Weak organic acids such as acetic and formic acids are necessarily released during the pretreatment (i.e. solubilization and hydrolysis) of lignocelluloses, which negatively affect microbial growth and ethanol production. However, since the mode of toxicity is complicated, genetic engineering strategies addressing yeast tolerance to weak organic acids have been rare. Thus, enhanced basic research is expected to identify target genes for improved weak acid tolerance. Results In this study, the effect of acetic acid on xylose fermentation was analyzed by examining metabolite profiles in a recombinant xylose-fermenting strain of Saccharomyces cerevisiae. Metabolome analysis revealed that metabolites involved in the non-oxidative pentose phosphate pathway (PPP) [e.g. sedoheptulose-7-phosphate, ribulose-5-phosphate, ribose-5-phosphate and erythrose-4-phosphate] were significantly accumulated by the addition of acetate, indicating the possibility that acetic acid slows down the flux of the pathway. Accordingly, a gene encoding a PPP-related enzyme, transaldolase or transketolase, was overexpressed in the xylose-fermenting yeast, which successfully conferred increased ethanol productivity in the presence of acetic and formic acid. Conclusions Our metabolomic approach revealed one of the molecular events underlying the response to acetic acid and focuses attention on the non-oxidative PPP as a target for metabolic engineering. An important challenge for metabolic engineering is identification of gene targets that have material importance. This study has demonstrated that metabolomics is a powerful tool to develop rational strategies to confer tolerance to stress through genetic engineering. PMID:21219616

  12. Metabolism

    MedlinePlus

    ... symptoms. Metabolic diseases and conditions include: Hyperthyroidism (pronounced: hi-per-THIGH-roy-dih-zum). Hyperthyroidism is caused ... or through surgery or radiation treatments. Hypothyroidism (pronounced: hi-po-THIGH-roy-dih-zum). Hypothyroidism is caused ...

  13. VEGF-A Expressing Adipose Tissue Shows Rapid Beiging, Enhanced Survival After Transplantation and Confers IL4-Independent Metabolic Improvements.

    PubMed

    Park, Jiyoung; Kim, Min; Sun, Kai; An, Yu Aaron; Gu, Xue; Scherer, Philipp E

    2017-03-02

    Adipocyte-derived VEGF-A plays a crucial role in angiogenesis and contributes to adipocyte function and systemic metabolism, such as insulin resistance, chronic inflammation and beigeing of subcutaneous adipose tissue. Utilizing a doxycycline (Dox)-inducible adipocyte-specific VEGF-A overexpressing mouse model, we investigated the dynamics of local VEGF-A effects on tissue beiging of adipose tissue transplants. VEGF-A overexpression in adipocytes triggers angiogenesis. We also observe a rapid appearance of beige fat cells in subcutaneous white adipose tissue (sWATs) within as early as 2 days post induction of VEGF-A. In contrast to conventional cold-induced beiging, VEGF-A - induced beiging is independent of IL-4. We subjected metabolically healthy VEGF-A overexpressing adipose tissue to autologous transplantation. Transfer of subcutaneous adipose tissues taken from VEGF-A overexpressing mice into diet-induced obese mice resulted in systemic metabolic benefits, associated with improved survival of adipocytes and a concomitant reduced inflammatory response. These effects of VEGF-A are tissue autonomous, inducing WAT beigeing and angiogenesis within the transplanted tissue. Our findings indicate that manipulation of adipocyte functions with a bona fide angiogenic factor, such as VEGF-A, significantly improves the survival and volume retention of fat grafts and can convey metabolically favorable properties on the recipient on the basis of beiging.

  14. Alterations in cerebral metabolism observed in living rodents using fluorescence lifetime microscopy of intrinsic NADH (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Yaseen, Mohammad A.; Sakadžić, Sava; Sutin, Jason; Wu, Weicheng; Fu, Buyin; Boas, David A.

    2017-02-01

    Monitoring cerebral energy metabolism at a cellular level is essential to improve our understanding of healthy brain function and its pathological alterations. In this study, we resolve specific alterations in cerebral metabolism utilizing minimally-invasive 2-Photon fluorescence lifetime imaging (2P-FLIM) measurements of reduced nicotinamide adenine dinucleotide (NADH) fluorescence, collected in vivo from anesthetized rats and mice. Time-resolved lifetime measurements enables distinction of different components contributing to NADH autofluorescence. These components reportedly represent different enzyme-bound formulations of NADH. Our observations from this study confirm the hypothesis that NADH FLIM can identify specific alterations in cerebral metabolism. Using time-correlated single photon counting (TCSPC) equipment and a custom-built multimodal imaging system, 2-photon fluorescence lifetime imaging (FLIM) was performed in cerebral tissue with high spatial and temporal resolution. Multi-exponential fits for NADH fluorescence lifetimes indicate 4 distinct components, or 'species.' We observed distinct variations in the relative proportions of these components before and after pharmacological-induced impairments to several reactions involved in anaerobic glycolysis and aerobic oxidative metabolism. Classification models developed with experimental data correctly predict the metabolic impairments associated with bicuculline-induced focal seizures in separate experiments. Compared to traditional intensity-based NADH measurements, lifetime imaging of NADH is less susceptible to the adverse effects of overlying blood vessels. Evaluating NADH measurements will ultimately lead to a deeper understanding of cerebral energetics and its pathology-related alterations. Such knowledge will likely aid development of therapeutic strategies for neurodegenerative diseases such as Alzheimer's Disease, Parkinson's disease, and stroke.

  15. Slow-release carbohydrates: growing evidence on metabolic responses and public health interest. Summary of the symposium held at the 12th European Nutrition Conference (FENS 2015).

    PubMed

    Vinoy, Sophie; Laville, Martine; Feskens, Edith J M

    2016-01-01

    To draw attention to the necessity of considering differences in the digestibility of carbohydrates, and more specifically of starch, a symposium was held at the 12th European Nutrition Conference (FENS), which took place in Berlin from October 20 to 23, 2015. The purpose of this session was to present the consolidated knowledge and recent advances regarding the relationship between slow-release carbohydrates, metabolic responses, and public health issues. Three main topics were presented: 1) the definition of, sources of, and recognised interest in the glycaemic response to slowly digestible starch (SDS); 2) clinical evidence regarding the physiological effects of slow-release carbohydrates from cereal foods; and 3) interest in reducing the postprandial glycaemic response to help prevent metabolic diseases. Foods with the highest SDS content induce the lowest glycaemic responses, as the starch is protected from gelatinisation during processing. In humans, high-SDS food consumption induces slower glucose release, lower postprandial insulinaemia, and stimulation of gut hormones. Moreover, postprandial hyperglycaemia is an independent risk factor for type two diabetes mellitus (T2DM) and cardiovascular disease (CVD). Therefore, given the plausible aetiologic mechanisms, we argue that postprandial glucose levels are relevant for health and disease and represent a meaningful target for intervention, for example, through dietary factors. This symposium was organised by Mondelez International R&D.

  16. Slow-release carbohydrates: growing evidence on metabolic responses and public health interest. Summary of the symposium held at the 12th European Nutrition Conference (FENS 2015)

    PubMed Central

    Vinoy, Sophie; Laville, Martine; Feskens, Edith J M

    2016-01-01

    To draw attention to the necessity of considering differences in the digestibility of carbohydrates, and more specifically of starch, a symposium was held at the 12th European Nutrition Conference (FENS), which took place in Berlin from October 20 to 23, 2015. The purpose of this session was to present the consolidated knowledge and recent advances regarding the relationship between slow-release carbohydrates, metabolic responses, and public health issues. Three main topics were presented: 1) the definition of, sources of, and recognised interest in the glycaemic response to slowly digestible starch (SDS); 2) clinical evidence regarding the physiological effects of slow-release carbohydrates from cereal foods; and 3) interest in reducing the postprandial glycaemic response to help prevent metabolic diseases. Foods with the highest SDS content induce the lowest glycaemic responses, as the starch is protected from gelatinisation during processing. In humans, high-SDS food consumption induces slower glucose release, lower postprandial insulinaemia, and stimulation of gut hormones. Moreover, postprandial hyperglycaemia is an independent risk factor for type two diabetes mellitus (T2DM) and cardiovascular disease (CVD). Therefore, given the plausible aetiologic mechanisms, we argue that postprandial glucose levels are relevant for health and disease and represent a meaningful target for intervention, for example, through dietary factors. This symposium was organised by Mondelez International R&D. PMID:27388153

  17. Results from the International Consensus Conference on Myo-inositol and d-chiro-inositol in Obstetrics and Gynecology: the link between metabolic syndrome and PCOS.

    PubMed

    Facchinetti, Fabio; Bizzarri, Mariano; Benvenga, Salvatore; D'Anna, Rosario; Lanzone, Antonio; Soulage, Christophe; Di Renzo, Gian Carlo; Hod, Moshe; Cavalli, Pietro; Chiu, Tony T; Kamenov, Zdravko A; Bevilacqua, Arturo; Carlomagno, Gianfranco; Gerli, Sandro; Oliva, Mario Montanino; Devroey, Paul

    2015-12-01

    In recent years, interest has been focused to the study of the two major inositol stereoisomers: myo-inositol (MI) and d-chiro-inositol (DCI), because of their involvement, as second messengers of insulin, in several insulin-dependent processes, such as metabolic syndrome and polycystic ovary syndrome. Although these molecules have different functions, very often their roles have been confused, while the meaning of several observations still needs to be interpreted under a more rigorous physiological framework. With the aim of clarifying this issue, the 2013 International Consensus Conference on MI and DCI in Obstetrics and Gynecology identified opinion leaders in all fields related to this area of research. They examined seminal experimental papers and randomized clinical trials reporting the role and the use of inositol(s) in clinical practice. The main topics were the relation between inositol(s) and metabolic syndrome, polycystic ovary syndrome (with a focus on both metabolic and reproductive aspects), congenital anomalies, gestational diabetes. Clinical trials demonstrated that inositol(s) supplementation could fruitfully affect different pathophysiological aspects of disorders pertaining Obstetrics and Gynecology. The treatment of PCOS women as well as the prevention of GDM seem those clinical conditions which take more advantages from MI supplementation, when used at a dose of 2g twice/day. The clinical experience with MI is largely superior to the one with DCI. However, the existence of tissue-specific ratios, namely in the ovary, has prompted researchers to recently develop a treatment based on both molecules in the proportion of 40 (MI) to 1 (DCI).

  18. Optical metabolic imaging of colorectal adenocarcinoma derived organoids: assessing cellular-level resistance to therapy (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    James, Haley M.; Prieto, Sandra P.; Greening, Gage J.; Muldoon, Timothy J.

    2017-02-01

    Locally advanced adenocarcinomas located in the distal rectum are commonly treated via 5-fluorouracil (5-FU)-based neoadjuvant chemoradiation therapy (CRT). The occurrence of pre-operative pathological complete response, or the absence of any histological evidence of residual cancer, is seen in 15-27% of rectal cancer cases. Response to chemotherapeutic agents varies between patients, introducing the need for a system to predict optimal drug combinations. We propose a method of utilizing optical metabolic imaging of in vitro, primary tumor-derived, three-dimensional organoid culture to create specific drug sensitivity profiles, and to rapidly assess a patient's potential response to drugs. Murine xenografts were developed in Swiss athymic nude mice, using human colorectal adenocarcinoma cell lines, implanted in the flank (RKO, ATCC). Tumors were excised upon reaching a volume of 500mm3 and processed for organoid culture. Organoids were subjected to longitudinal metabolic imaging of metabolic cofactors FAD and NADH for seven days. The resulting images were used to yield an optical redox value on a cell-by-cell basis, determined by the fluorescence intensity ratio of FAD/(FAD+NADH). This data infers proliferative index of the organoids. Beginning on day three, a control vehicle dimethyl sulfoxide, or the cytotoxic agent 5-FU, was added to the organoid growth media in wells, with metabolic imaging performed the same as previously stated. The optical redox values decreased due to the addition of 5-FU, which targets rapidly dividing cells and induces apoptosis. The changes in the optical redox histograms were correlated to markers of cell proliferation (Ki-67) and apoptosis (cleaved caspase-3).

  19. JNK1 ablation in mice confers long-term metabolic protection from diet-induced obesity at the cost of moderate skin oxidative damage.

    PubMed

    Becattini, Barbara; Zani, Fabio; Breasson, Ludovic; Sardi, Claudia; D'Agostino, Vito Giuseppe; Choo, Min-Kyung; Provenzani, Alessandro; Park, Jin Mo; Solinas, Giovanni

    2016-09-01

    Obesity and insulin resistance are associated with oxidative stress, which may be implicated in the progression of obesity-related diseases. The kinase JNK1 has emerged as a promising drug target for the treatment of obesity and type 2 diabetes. JNK1 is also a key mediator of the oxidative stress response, which can promote cell death or survival, depending on the magnitude and context of its activation. In this article, we describe a study in which the long-term effects of JNK1 inactivation on glucose homeostasis and oxidative stress in obese mice were investigated for the first time. Mice lacking JNK1 (JNK1(-/-)) were fed an obesogenic high-fat diet (HFD) for a long period. JNK1(-/-) mice fed an HFD for the long term had reduced expression of antioxidant genes in their skin, more skin oxidative damage, and increased epidermal thickness and inflammation compared with the effects in control wild-type mice. However, we also observed that the protection from obesity, adipose tissue inflammation, steatosis, and insulin resistance, conferred by JNK1 ablation, was sustained over a long period and was paralleled by decreased oxidative damage in fat and liver. We conclude that compounds targeting JNK1 activity in brain and adipose tissue, which do not accumulate in the skin, may be safer and most effective.-Becattini, B., Zani, F., Breasson, L., Sardi, C., D'Agostino, V. G., Choo, M.-K., Provenzani, A., Park, J. M., Solinas, G. JNK1 ablation in mice confers long-term metabolic protection from diet-induced obesity at the cost of moderate skin oxidative damage. © FASEB.

  20. Metabolic autofluorescence imaging of head and neck cancer organoids quantifies cellular heterogeneity and treatment response (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Shah, Amy T.; Heaster, Tiffany M.; Skala, Melissa C.

    2017-02-01

    Treatment options for head and neck cancer are limited, and can cause an impaired ability to eat, talk, and breathe. Therefore, optimized and personalized therapies could reduce unnecessary toxicities from ineffective treatments. Organoids are generated from primary tumor tissue and provide a physiologically-relevant in vitro model to measure drug response. Additionally, multiphoton fluorescence lifetime imaging (FLIM) of the metabolic cofactors NAD(P)H and FAD can resolve dynamic cellular response to anti-cancer treatment. This study applies FLIM of NAD(P)H and FAD to head and neck cancer organoids. Head and neck cancer tissue was digested and grown in culture as three-dimensional organoids. Gold standard measures of therapeutic response in vivo indicate stable disease after treatment with cetuximab (antibody therapy) or cisplatin (chemotherapy), and treatment response after combination treatment. In parallel, organoids were treated with cetuximab, cisplatin, or combination therapy for 24 hours. Treated organoids exhibit decreased NAD(P)H lifetime (p<0.05) and increased FAD lifetime (p<0.05) compared with control organoids. Additionally, analysis of cellular heterogeneity identifies distinct subpopulations of cells in response to treatment. A quantitative heterogeneity index predicts in vivo treatment response and demonstrates increased cellular heterogeneity in organoids treated with cetuximab or cisplatin compared with combination treatment. Mapping of cell subpopulations enables characterization of spatial relationships between cell subpopulations. Ultimately, an organoid model combined with metabolic fluorescence imaging could provide a high-throughput platform for drug discovery. Organoids grown from patient tissue could enable individualized treatment planning. These achievements could optimize quality of life and treatment outcomes for head and neck cancer patients.

  1. CRYAB and HSPB2 deficiency alters cardiac metabolism and paradoxically confers protection against myocardial ischemia in aging mice

    PubMed Central

    Benjamin, Ivor J.; Guo, Yiru; Srinivasan, Sathyanarayanan; Boudina, Sihem; Taylor, Ryan P.; Rajasekaran, Namakkal S.; Gottlieb, Roberta; Wawrousek, Eric F.; Abel, E. Dale; Bolli, Roberto

    2013-01-01

    The abundantly expressed small molecular weight proteins, CRYAB and HSPB2, have been implicated in cardioprotection ex vivo. However, the biological roles of CRYAB/HSPB2 coexpression for either ischemic preconditioning and/or protection in situ remain poorly defined. Wild-type (WT) and age-matched (~5–9 mo) CRYAB/HSPB2 double knockout (DKO) mice were subjected either to 30 min of coronary occlusion and 24 h of reperfusion in situ or preconditioned with a 4-min coronary occlusion/4-min reperfusion × 6, before similar ischemic challenge (ischemic preconditioning). Additionally, WT and DKO mice were subjected to 30 min of global ischemia in isolated hearts ex vivo. All experimental groups were assessed for area at risk and infarct size. Mitochondrial respiration was analyzed in isolated permeabilized cardiac skinned fibers. As a result, DKO mice modestly altered heat shock protein expression. Surprisingly, infarct size in situ was reduced by 35% in hearts of DKO compared with WT mice (38.8 ± 17.9 vs. 59.8 ± 10.6% area at risk, P < 0.05). In DKO mice, ischemic preconditioning was additive to its infarct-sparing phenotype. Similarly, infarct size after ischemia and reperfusion ex vivo was decreased and the production of superoxide and creatine kinase release was decreased in DKO compared with WT mice (P < 0.05). In permeabilized fibers, ADP-stimulated respiration rates were modestly reduced and calcium-dependent ATP synthesis was abrogated in DKO compared with WT mice. In conclusion, contrary to expectation, our findings demonstrate that CRYAB and HSPB2 deficiency induces profound adaptations that are related to 1) a reduction in calcium-dependent metabolism/respiration, including ATP production, and 2) decreased superoxide production during reperfusion. We discuss the implications of these disparate results in the context of phenotypic responses reported for CRYAB/HSPB2-deficient mice to different ischemic challenges. PMID:17873008

  2. OSBPL10, RXRA and lipid metabolism confer African-ancestry protection against dengue haemorrhagic fever in admixed Cubans

    PubMed Central

    Soares, Pedro; Garcia, Gissel; Perez, Ana B.; Aguirre, Eglys; Cavadas, Bruno; Regnault, Béatrice; Alvarez, Mayling; Ruiz, Didye; Guzman, Maria G.

    2017-01-01

    Ethnic groups can display differential genetic susceptibility to infectious diseases. The arthropod-born viral dengue disease is one such disease, with empirical and limited genetic evidence showing that African ancestry may be protective against the haemorrhagic phenotype. Global ancestry analysis based on high-throughput genotyping in admixed populations can be used to test this hypothesis, while admixture mapping can map candidate protective genes. A Cuban dengue fever cohort was genotyped using a 2.5 million SNP chip. Global ancestry was ascertained through ADMIXTURE and used in a fine-matched corrected association study, while local ancestry was inferred by the RFMix algorithm. The expression of candidate genes was evaluated by RT-PCR in a Cuban dengue patient cohort and gene set enrichment analysis was performed in a Thai dengue transcriptome. OSBPL10 and RXRA candidate genes were identified, with most significant SNPs placed in inferred weak enhancers, promoters and lncRNAs. OSBPL10 had significantly lower expression in Africans than Europeans, while for RXRA several SNPs may differentially regulate its transcription between Africans and Europeans. Their expression was confirmed to change through dengue disease progression in Cuban patients and to vary with disease severity in a Thai transcriptome dataset. These genes interact in the LXR/RXR activation pathway that integrates lipid metabolism and immune functions, being a key player in dengue virus entrance into cells, its replication therein and in cytokine production. Knockdown of OSBPL10 expression in THP-1 cells by two shRNAs followed by DENV2 infection tests led to a significant reduction in DENV replication, being a direct functional proof that the lower OSBPL10 expression profile in Africans protects this ancestry against dengue disease. PMID:28241052

  3. OSBPL10, RXRA and lipid metabolism confer African-ancestry protection against dengue haemorrhagic fever in admixed Cubans.

    PubMed

    Sierra, Beatriz; Triska, Petr; Soares, Pedro; Garcia, Gissel; Perez, Ana B; Aguirre, Eglys; Oliveira, Marisa; Cavadas, Bruno; Regnault, Béatrice; Alvarez, Mayling; Ruiz, Didye; Samuels, David C; Sakuntabhai, Anavaj; Pereira, Luisa; Guzman, Maria G

    2017-02-01

    Ethnic groups can display differential genetic susceptibility to infectious diseases. The arthropod-born viral dengue disease is one such disease, with empirical and limited genetic evidence showing that African ancestry may be protective against the haemorrhagic phenotype. Global ancestry analysis based on high-throughput genotyping in admixed populations can be used to test this hypothesis, while admixture mapping can map candidate protective genes. A Cuban dengue fever cohort was genotyped using a 2.5 million SNP chip. Global ancestry was ascertained through ADMIXTURE and used in a fine-matched corrected association study, while local ancestry was inferred by the RFMix algorithm. The expression of candidate genes was evaluated by RT-PCR in a Cuban dengue patient cohort and gene set enrichment analysis was performed in a Thai dengue transcriptome. OSBPL10 and RXRA candidate genes were identified, with most significant SNPs placed in inferred weak enhancers, promoters and lncRNAs. OSBPL10 had significantly lower expression in Africans than Europeans, while for RXRA several SNPs may differentially regulate its transcription between Africans and Europeans. Their expression was confirmed to change through dengue disease progression in Cuban patients and to vary with disease severity in a Thai transcriptome dataset. These genes interact in the LXR/RXR activation pathway that integrates lipid metabolism and immune functions, being a key player in dengue virus entrance into cells, its replication therein and in cytokine production. Knockdown of OSBPL10 expression in THP-1 cells by two shRNAs followed by DENV2 infection tests led to a significant reduction in DENV replication, being a direct functional proof that the lower OSBPL10 expression profile in Africans protects this ancestry against dengue disease.

  4. Label-free in vivo in situ diagnostic imaging by cellular metabolism quantification with a flexible multiphoton endomicroscope (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Leclerc, Pierre; Hage, Charles-Henri; Fabert, Marc; Brevier, Julien; O'Connor, Rodney P.; Bardet-Coste, Sylvia M.; Habert, Rémi; Braud, Flavie; Kudlinski, Alexandre; Louradour, Frederic

    2017-02-01

    Multiphoton microscopy is a cutting edge imaging modality leading to increasing advances in biology and also in the clinical field. To use it at its full potential and at the very heart of clinical practice, there have been several developments of fiber-based multiphoton microendoscopes. The application for those probes is now limited by few major restrictions, such as the difficulty to collect autofluorescence signals from tissues and cells theses being inherently weak (e.g. the ones from intracellular NADH or FAD metabolites). This limitation reduces the usefulness of microendoscopy in general, effectively restraining it to morphological imaging modality requiring staining of the tissues. Our aim is to go beyond this limitation, showing for the first time label-free cellular metabolism monitoring, in vivo in situ in real time. The experimental setup is an upgrade of a recently published one (Ducourthial et.al, Scientific Reports, 2016) where femtosecond pulse fiber delivery is further optimized thank's to a new transmissive-GRISM-based pulse stretcher permitting high energy throughput and wide bandwidth. This device allows fast sequential operation with two different excitation wavelengths for efficient two-photon excited NADH and FAD autofluorescence endoscopic detection (i.e. 860 nm for FAD and 760 nm for NADH), enabling cellular optical redox ratio quantification at 8 frames/s. The obtained results on cell models in vitro and also on animal models in vivo (e.g. neurons of a living mouse) prove that we accurately assess the level of NADH and FAD at subcellular resolution through a 3-meters-long fiber with our miniaturized probe (O.D. =2.2 mm).

  5. Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology.

    PubMed

    Gabryszewski, Stanislaw J; Dhingra, Satish K; Combrinck, Jill M; Lewis, Ian A; Callaghan, Paul S; Hassett, Matthew R; Siriwardana, Amila; Henrich, Philipp P; Lee, Andrew H; Gnädig, Nina F; Musset, Lise; Llinás, Manuel; Egan, Timothy J; Roepe, Paul D; Fidock, David A

    2016-11-01

    Southeast Asia is an epicenter of multidrug-resistant Plasmodium falciparum strains. Selective pressures on the subcontinent have recurrently produced several allelic variants of parasite drug resistance genes, including the P. falciparum chloroquine resistance transporter (pfcrt). Despite significant reductions in the deployment of the 4-aminoquinoline drug chloroquine (CQ), which selected for the mutant pfcrt alleles that halted CQ efficacy decades ago, the parasite pfcrt locus is continuously evolving. This is highlighted by the presence of a highly mutated allele, Cam734 pfcrt, which has acquired the singular ability to confer parasite CQ resistance without an associated fitness cost. Here, we used pfcrt-specific zinc-finger nucleases to genetically dissect this allele in the pathogenic setting of asexual blood-stage infection. Comparative analysis of drug resistance and growth profiles of recombinant parasites that express Cam734 or variants thereof, Dd2 (the most common Southeast Asian variant), or wild-type pfcrt, revealed previously unknown roles for PfCRT mutations in modulating parasite susceptibility to multiple antimalarial agents. These results were generated in the GC03 strain, used in multiple earlier pfcrt studies, and might differ in natural isolates harboring this allele. Results presented herein show that Cam734-mediated CQ resistance is dependent on the rare A144F mutation that has not been observed beyond Southeast Asia, and reveal distinct impacts of this and other Cam734-specific mutations on CQ resistance and parasite growth rates. Biochemical assays revealed a broad impact of mutant PfCRT isoforms on parasite metabolism, including nucleoside triphosphate levels, hemoglobin catabolism and disposition of heme, as well as digestive vacuole volume and pH. Results from our study provide new insights into the complex molecular basis and physiological impact of PfCRT-mediated antimalarial drug resistance, and inform ongoing efforts to characterize

  6. Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology

    PubMed Central

    Gabryszewski, Stanislaw J.; Dhingra, Satish K.; Lewis, Ian A.; Callaghan, Paul S.; Hassett, Matthew R.; Siriwardana, Amila; Henrich, Philipp P.; Lee, Andrew H.; Gnädig, Nina F.; Musset, Lise; Llinás, Manuel; Egan, Timothy J.; Roepe, Paul D.

    2016-01-01

    Southeast Asia is an epicenter of multidrug-resistant Plasmodium falciparum strains. Selective pressures on the subcontinent have recurrently produced several allelic variants of parasite drug resistance genes, including the P. falciparum chloroquine resistance transporter (pfcrt). Despite significant reductions in the deployment of the 4-aminoquinoline drug chloroquine (CQ), which selected for the mutant pfcrt alleles that halted CQ efficacy decades ago, the parasite pfcrt locus is continuously evolving. This is highlighted by the presence of a highly mutated allele, Cam734 pfcrt, which has acquired the singular ability to confer parasite CQ resistance without an associated fitness cost. Here, we used pfcrt-specific zinc-finger nucleases to genetically dissect this allele in the pathogenic setting of asexual blood-stage infection. Comparative analysis of drug resistance and growth profiles of recombinant parasites that express Cam734 or variants thereof, Dd2 (the most common Southeast Asian variant), or wild-type pfcrt, revealed previously unknown roles for PfCRT mutations in modulating parasite susceptibility to multiple antimalarial agents. These results were generated in the GC03 strain, used in multiple earlier pfcrt studies, and might differ in natural isolates harboring this allele. Results presented herein show that Cam734-mediated CQ resistance is dependent on the rare A144F mutation that has not been observed beyond Southeast Asia, and reveal distinct impacts of this and other Cam734-specific mutations on CQ resistance and parasite growth rates. Biochemical assays revealed a broad impact of mutant PfCRT isoforms on parasite metabolism, including nucleoside triphosphate levels, hemoglobin catabolism and disposition of heme, as well as digestive vacuole volume and pH. Results from our study provide new insights into the complex molecular basis and physiological impact of PfCRT-mediated antimalarial drug resistance, and inform ongoing efforts to characterize

  7. Conference Planning.

    ERIC Educational Resources Information Center

    Burke, W. Warner, Ed.; Beckhard, Richard, Ed.

    This book, written to instruct in the use of a conference as a medium of social intercourse, is divided into four sections. Section I, which contains five articles, deals with factors to be considered in planning a conference. Specific techniques one can employ to improve a conference and several different techniques for evaluating the…

  8. Conference Resolution

    NASA Astrophysics Data System (ADS)

    2009-04-01

    Since the first IUPAP International Conference on Women in Physics (Paris, March 2002) and the Second Conference (Rio de Janeiro, May 2005), progress has continued in most countries and world regions to attract girls to physics and advance women into leadership roles, and many working groups have formed. The Third Conference (Seoul, October 2008), with 283 attendees from 57 countries, was dedicated to celebrating the physics achievements of women throughout the world, networking toward new international collaborations, building each participant's capacity for career success, and aiding the formation of active regional working groups to advance women in physics. Despite the progress, women remain a small minority of the physics community in most countries.

  9. Investigate the variation in optical redox ratio of epicardial adipose tissue in patients with CAD through auto-fluorescence metabolic molecular image (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Guo, Lun-Zhang; Wang, Tzung-Dau; Lin, Jong-Wei; Liu, Tzu-Ming

    2016-04-01

    In recent years, it has been suggested that epicardial adipose tissue (EAT) plays an important role in development of coronary artery disease (CAD) and diabetes mellitus (DM). In this article, we used two-photon fluoresce microscope to measure the fluorescence metabolic image of EAT, which obtained from the patient with/without CAD/DM. We used 740nm and 890nm infrared light to excite the auto-fluorescence of metabolic molecules NADH and FAD respectively. We collected the fluorescence signal at wavelength 450nm to 500nm and 500nm to 550nm to obtain the metabolic image. Through the image, we computed the redox ratio (NADH/FAD) by analyzing the intensity. The preliminary result showed that the redox ratio increase in the patients with CAD. It indicates EAT adipocytes of patient with CAD have decreased cellular metabolic activity. But there were no significant variation of redox ratio in the patients with DM.

  10. MEASURING AND MODELLING METABOLISM

    EPA Science Inventory

    The use of QSAR with potential metabolism (bioactivation or deactivation) is an experimental approach for exploring toxicity pathways and estimating the relative toxicity of chemicals within a pathway. This conference will hear and discuss the potential and limitations of these ...

  11. Biomedical Conferences

    NASA Technical Reports Server (NTRS)

    1976-01-01

    As a result of Biomedical Conferences, Vivo Metric Systems Co. has produced cardiac electrodes based on NASA technology. Frequently in science, one highly specialized discipline is unaware of relevant advances made in other areas. In an attempt to familiarize researchers in a variety of disciplines with medical problems and needs, NASA has sponsored conferences that bring together university scientists, practicing physicians and manufacturers of medical instruments.

  12. Conference reports

    NASA Astrophysics Data System (ADS)

    Dongpei, Chen; Yulong, Ma

    1994-12-01

    The Ultrasonic Electronics Branch Society of the China Acoustics Society, and the Electronics Countermeasure Branch Society of the China Electronics Society held and All-China Applications Conference of Ultrasonic Electronics Devices in Electronic Countermeasures, Radar and Military Communication Technology. A total of 66 papers was received by the conference with contents relating to surface acoustic wave devices, high-frequency acoustic wave devices, acousto-optical devices, applications of devices in radar, applications of devices in electronic countermeasures, and applications of devices in military communication systems.

  13. Conference Summary

    ERIC Educational Resources Information Center

    Doherty, Cait

    2009-01-01

    This article summarizes an original conference, organised by the Child Care Research Forum (http://www.qub.ac.uk/sites/ccrf/), which brought together experts from all over Northern Ireland to showcase some of the wealth of research with children and young people that is going on in the country today. Developed around the six high-level outcomes of…

  14. The conference

    Treesearch

    Gordon M. Heisler; Lee P. Herrington

    1977-01-01

    This is a report on the Conference on Metropolitan Physical Environment, held in August 1975 at Syracuse, N.Y., where some 160 scientists and planners met to discuss the use of vegetation, space, and structures to improve the amenities for people who live in metropolitan areas.

  15. Conference Space

    ERIC Educational Resources Information Center

    Tillett, Wade

    2016-01-01

    The following is an exploration of the spatial configurations (and their implications) within a typical panel session at an academic conference. The presenter initially takes up different roles and hyperbolically describes some possible messages that the spatial arrangement sends. Eventually, the presenter engages the audience members in atypical…

  16. Conference Space

    ERIC Educational Resources Information Center

    Tillett, Wade

    2016-01-01

    The following is an exploration of the spatial configurations (and their implications) within a typical panel session at an academic conference. The presenter initially takes up different roles and hyperbolically describes some possible messages that the spatial arrangement sends. Eventually, the presenter engages the audience members in atypical…

  17. Conference Report: update on ADMET.

    PubMed

    Dearden, John C

    2009-05-01

    The first day of the conference, run by Select Biosciences, comprised a number of absorption, distribution, metabolism and excretion (ADME) training courses: digital ADME: creating optimized drug candidates from active molecules; exploring reciprocity: dynamic evaluation of ADME properties; hERG: the four commandments; and post rule-of-5 optimization parameters: binding kinetics in lead discovery and optimization. A total of 19 formal conference presentations were given on 24 and 25 February, and effectively covered two broad areas: in vitro and in silico. Several poster presentations were also on display throughout.

  18. Pharmacokinetic and Metabolic Studies of ADTM: A Novel Danshensu Derivative Confers Cardioprotection by HPLC-UV and LC-MS/MS.

    PubMed

    Li, Sai; Shan, Luchen; Zhang, Zaijun; Li, Wei; Liao, Kaiyi; Li, Sha; Sheng, Xiaoyan; Yu, Pei; Wang, Yuqiang

    2015-07-01

    (R)-(3,5,6-Trimethylpyrazinyl) methyl-2-acetoxy-3-(3,4-diacetoxyphenyl) propanoate (ADTM) is a novel Danshensu (DSS) derivative regarded as a potential new agent for the treatment of myocardial ischemia. A validated high performance liquid chromatography (HPLC) approach with a detection limit of 5 ng/mL was used for pharmacokinetic evaluation of ADTM in rat plasma. The intra- and interday precision in terms of relative standard deviation were <4.98 and 4.84%, respectively, at concentration levels of 0.02, 0.20 and 0.80 µg/mL. ADTM's absolute oral bioavailability value was 30.4% and t1/2 was 34.33 ± 11.51 and 29.94 ± 8.19 min after oral and intravenous administration of 20 mg/kg. In addition, the major metabolites both in vitro and in vivo were 2-hydroxymethy-3,5,6-trimethylpyrazin and DSS. The results indicated that the hydrolysis was the main metabolic pathway of ADTM, and carboxylesterase may play an important role in ADTM's metabolism. The present work provides basic information for ADTM's further preclinical research and DSS's chemical structure modification. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  19. Metabolic engineering of glycine betaine synthesis: plant betaine aldehyde dehydrogenases lacking typical transit peptides are targeted to tobacco chloroplasts where they confer betaine aldehyde resistance.

    PubMed

    Rathinasabapathi, B; McCue, K F; Gage, D A; Hanson, A D

    1994-01-01

    Certain higher plants synthesize and accumulate glycine betaine, a compound with osmoprotectant properties. Biosynthesis of glycine betaine proceeds via the pathway choline-->betaine aldehyde-->glycine betaine. Plants such as tobacco (Nicotiana tabacum L.) which do not accumulate glycine betaine lack the enzymes catalyzing both reactions. As a step towards engineering glycine betaine accumulation into a non-accumulator, spinach and sugar beet complementary-DNA sequences encoding the second enzyme of glycine-betaine synthesis (betaine aldehyde dehydrogenase, BADH, EC 1.2.1.8) were expressed in tobacco. Despite the absence of a typical transit peptide, BADH was targeted to the chloroplast in leaves of transgenic plants. Levels of extractable BADH were comparable to those in spinach and sugar beet, and the molecular weight, isoenzyme profile and Km for betaine aldehyde of the BADH enzymes from transgenic plants were the same as for native spinach or sugar beet BADH. Transgenic plants converted supplied betaine aldehyde to glycine betaine at high rates, demonstrating that they were able to transport betaine aldehyde across both the plasma membrane and the chloroplast envelope. The glycine betaine produced in this way was not further metabolized and reached concentrations similar to those in plants which accumulate glycine betaine naturally. Betaine aldehyde was toxic to non-transformed tobacco tissues whereas transgenic tissues were resistant due to detoxification of betaine aldehyde to glycine betaine. Betaine aldehyded ehydrogenase is therefore of interest as a potential selectable marker, as well as in the metabolic engineering of osmoprotectant biosynthesis.

  20. Respiratory muscle hemodynamic and metabolic adaptations to 16 weeks of training in varsity soccer players: near-infrared spectroscopy measurements during lung function tests (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Harris, R. Luke; Grob, Tanya; Sandhu, Komal; Schwab, Timothy

    2017-02-01

    The purpose of this study was to test the hypothesis that mobile, wireless near-infrared spectroscopy (NIRS) instruments can be used during standard lung function tests to measure adaptations in respiratory muscle metabolism over weeks to months. In eight varsity soccer players at 0 weeks and after 16 weeks of routine training, commercially available mobile, wireless NIRS instruments were used to measure oxygenation and hemodynamics in the sternocleidomastoid (SCM, accessory inspiration muscle). During maximal expiratory pressure (MEP) and forced vital capacity (FVC) maneuvers we determined peak or antipeak changes relative to baseline in oxygenation and hemodynamics: Δ%Sat (muscle oxygen saturation), ΔtHb (total hemoglobin), ΔO2Hb (oxygenated hemoglobin), and ΔHHb (deoxygenated hemoglobin). Subjects reported that the average training load was 13.3 h/week during the 16 study weeks, compared to 10.4 h/week during 12 prior weeks. After 16 weeks of training compared to 0 weeks we found statistically significant increases in SCM Δ%Sat (57.7%), ΔtHb (55.3%), and ΔO2Hb (56.7%) during MEP maneuvers, and in SCM Δ%Sat (64.8%), ΔtHb (29.4%), and ΔO2Hb (51.6%) during FVC maneuvers. Our data provide preliminary evidence that NIRS measurements during standard lung function tests are sufficiently sensitive to detect improvements or declines in respiratory muscle metabolism over periods of weeks to months due to training, disease, and rehabilitation exercise.

  1. Next conference

    NASA Astrophysics Data System (ADS)

    Hexemer, Alexander; Toney, Michael F.

    2010-11-01

    After the successful conference on Synchrotron Radiation in Polymer Science (SRPS) in Rolduc Abbey (the Netherlands), we are now looking forward to the next meeting in this topical series started in 1995 by H G Zachmann, one of the pioneers of the use of synchrotron radiation techniques in polymer science. Earlier meetings were held in Hamburg (1995), Sheffield (2002), Kyoto (2006), and Rolduc (2009). In September of 2012 the Synchrotron Radiation and Polymer Science V conferences will be organized in a joint effort by the SLAC National Accelerator Laboratory and Lawrence Berkeley National Laboratory. Stanford Linear Accelerator Laboratory Stanford Linear Accelerator Laboratory Advanced Light Source at LBL Advanced Light Source at LBL The conference will be organised in the heart of beautiful San Francisco. The program will consist of invited and contributed lectures divided in sessions on the use of synchrotron SAXS/WAXD, imaging and tomography, soft x-rays, x-ray spectroscopy, GISAXS and reflectivity, micro-beams and hyphenated techniques in polymer science. Poster contributions are more than welcome and will be highlighted during the poster sessions. Visits to both SLAC as well as LBL will be organised. San Francisco can easily be reached. It is served by two major international airports San Francisco International Airport and Oakland International Airport. Both are being served by most major airlines with easy connections to Europe and Asia as well as national destinations. Both also boast excellent connections to San Francisco city centre. We are looking forward to seeing you in the vibrant city by the Bay in September 2012. Golden gate bridge Alexander Hexemer Lawrence Berkeley National Laboratory, Advanced Light Source, Berkeley, CA 94720, USA Michael F Toney Stanford Synchrotron Radiation Lightsource, Menlo Pk, CA 94025, USA E-mail: ahexemer@lbl.gov, mftoney@slac.stanford.edu

  2. Conferences revisited

    NASA Astrophysics Data System (ADS)

    Radcliffe, Jonathan

    2008-08-01

    Way back in the mid-1990s, as a young PhD student, I wrote a Lateral Thoughts article about my first experience of an academic conference (Physics World 1994 October p80). It was a peach of a trip - most of the lab decamped to Grenoble for a week of great weather, beautiful scenery and, of course, the physics. A whole new community was there for me to see in action, and the internationality of it all helped us to forget about England's non-appearance in the 1994 World Cup finals.

  3. An Engineered Monolignol 4-O-Methyltransferase Depresses Lignin Biosynthesis and Confers Novel Metabolic Capability in Arabidopsis[C][W][OA

    PubMed Central

    Zhang, Kewei; Bhuiya, Mohammad-Wadud; Pazo, Jorge Rencoret; Miao, Yuchen; Kim, Hoon; Ralph, John; Liu, Chang-Jun

    2012-01-01

    Although the practice of protein engineering is industrially fruitful in creating biocatalysts and therapeutic proteins, applications of analogous techniques in the field of plant metabolic engineering are still in their infancy. Lignins are aromatic natural polymers derived from the oxidative polymerization of primarily three different hydroxycinnamyl alcohols, the monolignols. Polymerization of lignin starts with the oxidation of monolignols, followed by endwise cross-coupling of (radicals of) a monolignol and the growing oligomer/polymer. The para-hydroxyl of each monolignol is crucial for radical generation and subsequent coupling. Here, we describe the structure-function analysis and catalytic improvement of an artificial monolignol 4-O-methyltransferase created by iterative saturation mutagenesis and its use in modulating lignin and phenylpropanoid biosynthesis. We show that expressing the created enzyme in planta, thus etherifying the para-hydroxyls of lignin monomeric precursors, denies the derived monolignols any participation in the subsequent coupling process, substantially reducing lignification and, ultimately, lignin content. Concomitantly, the transgenic plants accumulated de novo synthesized 4-O-methylated soluble phenolics and wall-bound esters. The lower lignin levels of transgenic plants resulted in higher saccharification yields. Our study, through a structure-based protein engineering approach, offers a novel strategy for modulating phenylpropanoid/lignin biosynthesis to improve cell wall digestibility and diversify the repertories of biologically active compounds. PMID:22851762

  4. Improved accuracy of brain oxygen metabolism measurements using multi-distance diffuse correlation spectroscopy and near infrared spectroscopy together with a Monte Carlo light transport model (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Carp, Stefan A.; Boas, David A.; Selb, Juliette J.

    2017-02-01

    Diffuse correlation spectroscopy (DCS) is being employed alongside near-infrared spectroscopy (NIRS) measurements to track the cerebral oxygen metabolic rate (CMRO2). However, both techniques employ diffusely reflected light that has traveled mostly through extracerebral tissues. Recent studies indicate that depth sensitivity profiles are different for NIRS vs DCS measurements, with DCS appearing to be more sensitive to the brain than NIRS methods for a given source-detector separation. This mismatch can lead to erroneous conclusions with respect to the amount and perhaps even the direction of change in CMRO2. Recently, our group and others have demonstrated the use of Monte Carlo (MC) based multi-layer, multi-distance fitting, which offers increased accuracy for complex tissue structures such as the adult brain. In this paper we employ a Monte Carlo light transport model based on a realistic head geometry that can be derived from MRI scans (if available) or approximated from head shape measurements. We consider DCS and CW-NIRS measurements taken at two or more distances and analyze simulated data generated using a fully segmented adult brain MRI scan. Through simulations, we explore the improvements offered by our method vs. processing the same measurements with a semi-infinite diffusion model and estimate the impact of errors in geometry and optical properties on relative blood flow and CMRO2 changes.

  5. Trans-cranial infrared laser stimulation induces hemodynamic and metabolic response measured by broadband near infrared spectroscopy in vivo on human forehead (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Wang, Xinlong; Nalawade, Sahil Sunil; Reddy, Divya Dhandapani; Tian, Fenghua; Gonzalez-Lima, F.; Liu, Hanli

    2017-02-01

    Transcranial infrared laser stimulation (TILS) uses infrared light (lasers or LEDs) for nondestructive and non-thermal photobiomodulation on the human brain. Although TILS has shown its beneficial effects to a variety of neurological and psychological conditions, its physiological mechanism remains unknown. Cytochrome-c-oxidase (CCO), the last enzyme in the electron transportation chain, is proposed to be the primary photoacceptor of this infrared laser. In this study, we wish to validate this proposed mechanism. We applied 8 minutes in vivo TILS on the right forehead of 11 human participants with a 1064-nm laser. Broad-band near infrared spectroscopy (bb-NIRS) from 740-900nm was also employed near the TILS site to monitor hemodynamic and metabolic responses during the stimulation and 5-minute recovery period. For rigorous comparison, we also performed similar 8-min bb-NIR measurements under placebo conditions. A multi-linear regression analysis based on the modified Beer-Lambert law was performed to estimate concentration changes of oxy-hemoglobin (Δ[HbO]), deoxy-hemoglobin (Δ[Hb]), and cytochrome-c-oxidase (Δ[CCO]). We found that TILS induced significant increases of [CCO], [HbO] and a decrease of [Hb] with dose-dependent manner as compared with placebo treatments. Furthermore, strong linear relationships or interplays between [CCO] versus [HbO] and [CCO] versus [Hb] induced by TILS were observed in vivo for the first time. These relationships have clearly revealed close coupling/relationship between the hemodynamic oxygen supply and blood volume versus up-regulation of CCO induced by photobiomodulation. Our results demonstrate the tremendous potential of bb-NIRS as a non-invasive in vivo means to study photobiomodulation mechanisms and perform treatment evaluations of TILS.

  6. Development of a NIRS method to quantify cerebral perfusion and oxidative metabolism in preterm infants with post-hemorrhagic ventricle dilation (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    McLachlan, Peter; Kishimoto, Jessica; de Ribeaupierre, Sandrine; Lee, David S. C.; Diop, Mamadou; St Lawrence, Keith

    2017-02-01

    A complication of intraventricular hemorrhage among preterm neonates is post-hemorrhagic ventricle dilation (PHVD), which is associated with a greater risk of life-long neurological disability. Clinical evidence, including suppressed EEG patterns, suggests that cerebral perfusion and oxygenation is impaired in these patients, likely due to elevated intracranial pressure (ICP). Cerebral blood flow (CBF) and the cerebral metabolic rate of oxygen (CMRO2) can be quantified by dynamic contrast-enhanced NIRS; however, PHVD poses a unique challenge to NIRS since the cerebral mantle can be compressed to 1 cm or less. The objectives of this work were to develop a finite-slab model for the analysis of NIRS spectra, incorporating depth measurements from ultrasound images, and to assess the magnitude of error when using the standard semi-infinite model. CBF, tissue saturation (StO2) and CMRO2 were measured in 9 patients receiving ventricle taps to reduce ICP. Monte Carlo simulations indicated that errors in StO2 could be greater than 20% if the cerebral mantle was reduced to 1 cm. Using the finite-slab model, basal CBF and CMRO2 in the PHVD patients were not significantly different from a control group of preterm infants (14.6 ± 4.2 ml/100 g/min and 1.0 ± 0.4 ml O2/100 g/min), but StO2 was significantly lower (PDA 70.5 ± 9%, PHVD 58.9 ± 12%). Additionally, ventricle tapping improved CBF by 15.6 ± 22%. This work indicates that applying NIRS to PHVD patients is prone to error; however, this issue can be overcome with the appropriate model and using readily available ultrasound images.

  7. Interfacing microbiology and biotechnology. Conference abstracts

    SciTech Connect

    Maupin, Julia A.

    2001-05-19

    The Interfacing Microbiology and Biotechnology Conference was attended by over 100 faculty, post-docs, students, and research scientists from the US, Europe, and Latin America. The conference successfully stimulated communication and the dissemination of knowledge among scientists involved in basic and applied research. The focus of the conference was on microbial physiology and genetics and included sessions on C1 metabolism, archaeal metabolism, proteases and chaperones, gene arrays, and metabolic engineering. The meeting provided the setting for in-depth discussions between scientists who are internationally recognized for their research in these fields. The following objectives were met: (1) The promotion of interaction and future collaborative projects among scientists involved in basic and applied research which incorporates microbial physiology, genetics, and biochemistry; (2) the facilitation of communication of new research findings through seminars, posters, and abstracts; (3 ) the stimulation of enthusiasm and education among participants including graduate and undergraduate students.

  8. Aberrant intracellular metabolism of T-DM1 confers T-DM1 resistance in HER2-positive gastric cancer cells.

    PubMed

    Wang, Hongbin; Wang, Wenqian; Xu, Yongping; Yang, Yong; Chen, Xiaoyan; Quan, Haitian; Lou, Liguang

    2017-04-07

    T-DM1 (Kadcyla), an antibody-drug conjugate (ADC) consisting of HER2-targeted monoclonal antibody trastuzumab linked to anti-microtubule agent mertansine (DM1), has been approved for the treatment of HER2-positive metastatic breast cancer. To date, acquired resistance arises to be a major obstacle to T-DM1 treatment, and mechanisms remain incompletely understood. In the present study, we established a T-DM1-resistant N87-KR cell line from HER2-positive N87 gastric cancer cells to investigate mechanisms of acquired resistance and develop strategies for overcoming it. Although the kinetics of binding, internalization, and externalization of T-DM1 were the same in N87-KR cells and N87 cells, N87-KR was strongly resistant to T-DM1, but remained sensitive to both trastuzumab and DM1. T-DM1 failed to inhibit microtubule polymerization in N87-KR cells. Consistently, lysine-MCC-DM1, the active T-DM1 metabolite that inhibits microtubule polymerization, accumulated much lesser in N87-KR cells. Furthermore, lysosome acidification, achieved by V-ATPase, was much diminished in N87-KR cells. Notably, treatment of sensitive N87 cells with the V-ATPase-selective inhibitor Baf-A1 induced T-DM1 resistance, suggesting that aberrant V-ATPase activity decreases T-DM1 metabolism, leading to T-DM1 resistance in N87-KR cells. Interestingly, HER2-targeted ADCs containing a protease-cleavable linker, such as hertuzumab-vc-MMAE, were capable of efficiently overcoming this resistance. Our results demonstrate for the first time that a decrease in T-DM1 metabolites induced by aberrant V-ATPase activity contributes to T-DM1 resistance, which could be overcome by HER2-targeted ADC containing different linkers, including a protease-cleavable linker. Accordingly, we propose that V-ATPase activity in lysosomes is a novel biomarker for predicting T-DM1 resistance. This article is protected by copyright. All rights reserved.

  9. Conference Summary

    NASA Astrophysics Data System (ADS)

    Sanders, David B.

    2014-07-01

    This conference on ``Multi-wavelength AGN Surveys and Studies'' has provided a detailed look at the explosive growth over the past decade, of available astronomical data from a growing list of large scale sky surveys, from radio-to-gamma rays. We are entering an era were multi-epoch (months to weeks) surveys of the entire sky, and near-instantaneous follow-up observations of variable sources, are elevating time-domain astronomy to where it is becoming a major contributor to our understanding of Active Galactic Nuclei (AGN). While we can marvel at the range of extragalactic phenomena dispayed by sources discovered in the original ``Markarian Survey'' - the first large-scale objective prism survey of the Northern Sky carried out at the Byurakan Astronomical Observtory almost a half-century ago - it is clear from the talks and posters presented at this meeting that the data to be be obtained over the next decade will be needed if we are to finally understand which phase of galaxy evolution each Markarian Galaxy represents.

  10. Conference Scene

    PubMed Central

    Leeder, J Steven; Lantos, John; Spielberg, Stephen P

    2015-01-01

    A major challenge for clinicians, pharmaceutical companies and regulatory agencies is to better understand the relative contributions of ontogeny and genetic variation to observed variability in drug disposition and response across the pediatric age spectrum from preterm and term newborns, to infants, children and adolescents. Extrapolation of adult experience with pharmacogenomics and personalized medicine to pediatric patients of different ages and developmental stages, is fraught with many challenges. Compared with adults, pediatric pharmacogenetics and pharmacogenomics involves an added measure of complexity as variability owing to developmental processes, or ontogeny, is superimposed upon genetic variation. Furthermore, some pediatric diseases have no adult correlate or are more prevalent in children compared with adults, and several adverse drug reactions are unique to children, or occur at a higher frequency in children. The primary objective of this conference was to initiate an ongoing series of annual meetings on ‘Pediatric Pharmacogenomics and Personalized Medicine’ organized by the Center for Personalized Medicine and Therapeutic Innovation and Division of Clinical Pharmacology and Medical Therapeutics at Children’s Mercy Hospitals and Clinics in Kansas City, MO, USA. The primary goals of the inaugural meeting were: to bring together clinicians, basic and translational scientists and allied healthcare practitioners, and engage in a multi- and cross-disciplinary dialog aimed at implementing personalized medicine in pediatric settings; to provide a forum for the presentation and the dissemination of research related to the application of pharmacogenomic strategies to investigations of variability of drug disposition and response in children; to explore the ethical, legal and societal implications of pharmacogenomics and personalized medicine that are unique to children; and finally, to create networking opportunities for stimulating discussion

  11. Conference Abstracts: AEDS '82.

    ERIC Educational Resources Information Center

    Journal of Computers in Mathematics and Science Teaching, 1982

    1982-01-01

    Abstracts from nine selected papers presented at the 1982 Association for Educational Data Systems (AEDS) conference are provided. Copies of conference proceedings may be obtained for fifteen dollars from the Association. (MP)

  12. Parent Conferences. Beginnings Workshop.

    ERIC Educational Resources Information Center

    Duffy, Roslyn; And Others

    1997-01-01

    Presents six workshop sessions on parent conferences: (1) "Parents' Perspectives on Conferencing" (R. Duffy); (2) "Three Way Conferences" (G. Zeller); (3) "Conferencing with Parents of Infants" (K. Albrecht); (4) "Conferencing with Parents of School-Agers" (L. G. Miller); (5) "Cross Cultural Conferences" (J. Gonzalez-Mena); and (6) "Working with…

  13. EDITORIAL: Conference program

    NASA Astrophysics Data System (ADS)

    2006-04-01

    Some of the papers and talks given at the conference have not been published in this volume of Journal of Physics: Conference Series. The attached PDF file lists the full conference program and indicates (with an asterisk) those papers or talks which are not present in this volume.

  14. The General Conference Mennonites.

    ERIC Educational Resources Information Center

    Ediger, Marlow

    General Conference Mennonites and Old Order Amish are compared and contrasted in the areas of physical appearance, religious beliefs, formal education, methods of farming, and home settings. General Conference Mennonites and Amish differ in physical appearance and especially in dress. The General Conference Mennonite men and women dress the same…

  15. Youth Conference Handbook.

    ERIC Educational Resources Information Center

    Brown, Brenda H.

    This handbook is designed to provide practical aid to those who have charge of the planning and organization of a youth conference, Defined as a conference to provide practical information as well as information about possible responsibilities, risks, and consequences of actions, related to the chosen conference topic. Suggestions are given for…

  16. 47 CFR 1.248 - Prehearing conferences; hearing conferences.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Prehearing conferences; hearing conferences. 1... Hearing Proceedings Prehearing Procedures § 1.248 Prehearing conferences; hearing conferences. (a) The... to appear at a specified time and place for a conference prior to a hearing, or to submit...

  17. GE STEM Teacher's Conference

    NASA Image and Video Library

    2017-07-13

    Teachers participate in the Rocketry Engineering Design Challenge during the 2017 GE Foundation High School STEM Integration Conference at the Center for Space Education at NASA's Kennedy Space Center. High school teachers from across the country took part in the week-long conference, which is designed to explore effective ways for teachers, schools and districts from across the country to integrate STEM throughout the curriculum. The conference is a partnership between GE Foundation and the National Science Teachers Association.

  18. Epigenetics and metabolism.

    PubMed

    Keating, Samuel T; El-Osta, Assam

    2015-02-13

    The molecular signatures of epigenetic regulation and chromatin architectures are fundamental to genetically determined biological processes. Covalent and post-translational chemical modification of the chromatin template can sensitize the genome to changing environmental conditions to establish diverse functional states. Recent interest and research focus surrounds the direct connections between metabolism and chromatin dynamics, which now represents an important conceptual challenge to explain many aspects of metabolic dysfunction. Several components of the epigenetic machinery require intermediates of cellular metabolism for enzymatic function. Furthermore, changes to intracellular metabolism can alter the expression of specific histone methyltransferases and acetyltransferases conferring widespread variations in epigenetic modification patterns. Specific epigenetic influences of dietary glucose and lipid consumption, as well as undernutrition, are observed across numerous organs and pathways associated with metabolism. Studies have started to define the chromatin-dependent mechanisms underlying persistent and pathophysiological changes induced by altered metabolism. Importantly, numerous recent studies demonstrate that gene regulation underlying phenotypic determinants of adult metabolic health is influenced by maternal and early postnatal diet. These emerging concepts open new perspectives to combat the rising global epidemic of metabolic disorders.

  19. 76 FR 64083 - Reliability Technical Conference; Notice of Technical Conference

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-17

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Reliability Technical Conference; Notice of Technical Conference Take notice that the Federal Energy Regulatory Commission will hold a Technical Conference on Tuesday, November...

  20. 2007 Archaea: Ecology, Metabolism and Molecular Biology

    SciTech Connect

    Imke Schroeder Nancy Ryan Gray

    2008-09-18

    The Archaea are a fascinating and diverse group of prokaryotic organisms with deep roots overlapping those of eukaryotes. The focus of this GRC conference, 'Archaea: Ecology Metabolism & Molecular Biology', expands on a number of emerging topics highlighting the evolution and composition of microbial communities and novel archaeal species, their impact on the environment, archaeal metabolism, and research that stems from sequence analysis of archaeal genomes. The strength of this conference lies in its ability to couple reputable areas with new scientific topics in an atmosphere of stimulating exchange. This conference remains an excellent opportunity for younger scientists to interact with world experts in this field.

  1. ASE Annual Conference 2010

    ERIC Educational Resources Information Center

    McCune, Roger

    2010-01-01

    In this article, the author describes the ASE Annual Conference 2010 which was held at Nottingham after a gap of 22 years. As always, the main conference was preceded by International Day, an important event for science educators from across the world. There were two strands to the programme: (1) "What works for me?"--sharing new ideas…

  2. District Leadership Conference Planner.

    ERIC Educational Resources Information Center

    Washington State Coordinating Council for Occupational Education, Olympia.

    This manual provides usable guidelines and planning forms and materials for planning district leadership conferences, which were designed and initiated in Washington State to meet the problems in student enrollment and, consequently, Distributive Education Clubs of America membership. The conferences have become a useful means to increase…

  3. [Conference Time Kit.

    ERIC Educational Resources Information Center

    National School Public Relations Association, Washington, DC.

    This multimedia kit, for use with and by teachers from kindergarten through the upper elementary grades, consists of four components: 1) a filmstrip for teachers; 2) the 1970 edition of a handbook, "Conference Time for Teachers and Parents"; 3) a filmstrip for parents; 4) a supporting parent information leaflet "How To Confer Successfully with…

  4. Facilitating Learning at Conferences

    ERIC Educational Resources Information Center

    Ravn, Ib; Elsborg, Steen

    2011-01-01

    The typical conference consists of a series of PowerPoint presentations that tend to render participants passive. Students of learning have long abandoned the transfer model that underlies such one-way communication. We propose an alternative theory of conferences that sees them as a forum for learning, mutual inspiration and human flourishing. We…

  5. The Learning Conference

    ERIC Educational Resources Information Center

    Ravn, Ib

    2007-01-01

    Purpose: The purpose of this paper is to call attention to the fact that conferences for professionals rely on massive one-way communication and hence produce little learning for delegates--and to introduce an alternative, the "learning conference", that involves delegates in fun and productive learning processes.…

  6. The Learning Conference

    ERIC Educational Resources Information Center

    Ravn, Ib

    2007-01-01

    Purpose: The purpose of this paper is to call attention to the fact that conferences for professionals rely on massive one-way communication and hence produce little learning for delegates--and to introduce an alternative, the "learning conference", that involves delegates in fun and productive learning processes.…

  7. Lyndon Johnson's Press Conferences.

    ERIC Educational Resources Information Center

    Cooper, Stephen

    Because President Lyndon Johnson understood well the publicity value of the American news media, he sought to exploit them. He saw reporters as "torch bearers" for his programs and policies and used the presidential press conference chiefly for promotional purposes. Although he met with reporters often, his press conferences were usually…

  8. ASE Annual Conference 2010

    ERIC Educational Resources Information Center

    McCune, Roger

    2010-01-01

    In this article, the author describes the ASE Annual Conference 2010 which was held at Nottingham after a gap of 22 years. As always, the main conference was preceded by International Day, an important event for science educators from across the world. There were two strands to the programme: (1) "What works for me?"--sharing new ideas…

  9. From Conference to Journal

    ERIC Educational Resources Information Center

    McCartney, Robert; Tenenberg, Josh

    2008-01-01

    Revising and extending conference articles for journal publication benefits both authors and readers. The new articles are more complete, and benefit from peer review, feedback from conference presentation, and greater editorial consistency. For those articles that are appropriate, we encourage authors to do this, and present two examples of such…

  10. ICCK Conference Final Report

    SciTech Connect

    Green, William H.

    2013-05-28

    The 7th International Conference on Chemical Kinetics (ICCK) was held July 10-14, 2011, at Massachusetts Institute of Technology (MIT), in Cambridge, MA, hosted by Prof. William H. Green of MIT's Chemical Engineering department. This cross-disciplinary meeting highlighted the importance of fundamental understanding of elementary reactions to the full range of chemical investigations. The specific conference focus was on elementary-step kinetics in both the gas phase and in condensed phase. The meeting provided a unique opportunity to discuss how the same reactive species and reaction motifs manifest under very different reaction conditions (e.g. atmospheric, aqueous, combustion, plasma, in nonaqueous solvents, on surfaces.). The conference featured special sessions on new/improved experimental techniques, improved models and data analysis for interpreting complicated kinetics, computational kinetics (especially rate estimates for large kinetic models), and a panel discussion on how the community should document/archive kinetic data. In the past, this conference had been limited to homogeneous gas-phase and liquid-phase systems. This conference included studies of heterogeneous kinetics which provide rate constants for, or insight into, elementary reaction steps. This Grant from DOE BES covered about half of the subsidies we provided to students and postdocs who attended the conference, by charging them reduced-rate registration fees. The complete list of subsidies provided are listed in Table 1 below. This DOE funding was essential to making the conference affordable to graduate students, and indeed the attendance at this conference was higher than at previous conferences in this series. Donations made by companies provided additional subsidies, leveraging the DOE funding. The conference was very effective in educating graduate students and important in fostering scientific interactions, particularly between scientists studying gas phase and liquid phase kinetics

  11. 1985 oil spill conference

    SciTech Connect

    Not Available

    1985-02-01

    This 1985 Oil Spill Conference, our ninth biennial meeting, presents another unique opportunity fo industry, government, and academic representatives to meet and exchange ideas to enhance our knowledge and understanding of the prevention, behavior, control, and cleanup of oil spills. Growing international and domestic participation, and the continued worldwide use of the Proceedings of past oil spill conferences as valuable reference sources affirms the importance and quality of these conferences. It is my firm belief, furthermore, that the conferences have contributed substantially to the reduction in the number of marine oil spills, and to our increased cleanup capabilities. The sponsoring organizations--the United States Coast Guard, the American Petroleum Institute, and the United States Environmental Protection Agency--have combined their efforts to provide a program of timely technical content which affords the opportunity to review the state-of-the-art accomplishments since our last conference in 1983. Finally, I hope that the knowledge and associations developed at this conference will influence your decision to participate in the 1987 Oil Spill Conference, to be held in Baltimore, Maryland.

  12. Conference Report: Wyoming Invitational Conference on Instructional Applications of Computers.

    ERIC Educational Resources Information Center

    Kansky, Bob

    This report: (1) describes the organization of an invitational conference aimed at gathering direction from classroom teachers regarding instructional applications of computers; (2) provides copies of all materials used in organizing such a conference; and (3) reports the results of the conference in terms of conference products (resolutions,…

  13. 48 CFR 6101.11 - Conferences; conference memorandum [Rule 11].

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Conferences; conference memorandum . 6101.11 Section 6101.11 Federal Acquisition Regulations System CIVILIAN BOARD OF CONTRACT APPEALS, GENERAL SERVICES ADMINISTRATION CONTRACT DISPUTE CASES 6101.11 Conferences; conference...

  14. GE STEM Teacher's Conference

    NASA Image and Video Library

    2017-07-13

    Teachers prepare to demonstrate the projects they built for the Rocketry Engineering Design Challenge during the 2017 GE Foundation High School STEM Integration Conference at the Center for Space Education at NASA's Kennedy Space Center. High school teachers from across the country took part in the week-long conference, which is designed to explore effective ways for teachers, schools and districts from across the country to integrate STEM throughout the curriculum. The conference is a partnership between GE Foundation and the National Science Teachers Association.

  15. GE STEM Teacher's Conference

    NASA Image and Video Library

    2017-07-13

    Education Specialists Lynn Dotson, left, of the NASA Public Engagement Center, and Lester Morales, right, of Texas State University's NASA STEM Educator Professional Development Collaborative, explain the Rocketry Engineering Design Challenge to teachers participating in the 2017 GE Foundation High School STEM Integration Conference at the Center for Space Education at NASA's Kennedy Space Center. High school teachers from across the country took part in the week-long conference, which is designed to explore effective ways for teachers, schools and districts from across the country to integrate STEM throughout the curriculum. The conference is a partnership between GE Foundation and the National Science Teachers Association.

  16. Aircraft Engine Emissions. [conference

    NASA Technical Reports Server (NTRS)

    1977-01-01

    A conference on a aircraft engine emissions was held to present the results of recent and current work. Such diverse areas as components, controls, energy efficient engine designs, and noise and pollution reduction are discussed.

  17. Expedition 52 Press Conference

    NASA Image and Video Library

    2017-07-10

    Expedition 52 flight engineer Randy Bresnik of NASA answers a reporter's question during a crew press conference at the Gagarin Cosmonaut Training Center (GCTC), Monday, July 10, 2017 in Star City, Russia. Photo Credit: (NASA/Bill Ingalls)

  18. STS-135 Press Conference

    NASA Image and Video Library

    2011-06-30

    JSC2011-E-060448 (30 June 2011) --- NASA astronaut Rex Walheim, STS-135 mission specialist, fields a question from a reporter during a preflight press conference at NASA's Johnson Space Center. Photo credit: NASA

  19. Expedition 52 Press Conference

    NASA Image and Video Library

    2017-07-10

    Expedition 52 flight engineer Sergey Ryazanskiy of Roscosmos answers a reporter's question during a crew press conference at the Gagarin Cosmonaut Training Center (GCTC), Monday, July 10, 2017 in Star City, Russia. Photo Credit: (NASA/Bill Ingalls)

  20. STS-135 Press Conference

    NASA Image and Video Library

    2011-06-30

    JSC2011-E-060450 (30 June 2011) --- NASA astronaut Rex Walheim, STS-135 mission specialist, responds to a question from a reporter during a preflight press conference at NASA's Johnson Space Center. Photo credit: NASA

  1. Expedition 32 Press Conference

    NASA Image and Video Library

    2012-07-13

    Quarantined Expedition 32 Canadian backup crewmember Chris Hadfield answers reporters questions from behind glass during a prelaunch press conference held at the Cosmonaut Hotel on Friday, July 13, 2012 in Baikonur, Kazakhstan. Photo Credit (NASA/Carla Cioffi)

  2. STS-134 Press Conference

    NASA Image and Video Library

    2011-03-24

    JSC2011-E-028493 (24 March 2011) --- NASA astronaut Mark Kelly, STS-134 commander, responds to a question from a reporter during a preflight press conference at NASA's Johnson Space Center. Photo credit: NASA or National Aeronautics and Space Administration

  3. STS-135 Press Conference

    NASA Image and Video Library

    2011-06-30

    JSC2011-E-060415 (30 June 2011) --- NASA astronaut Sandy Magnus, STS-135 mission specialist, responds to a question from a reporter during a preflight press conference at NASA's Johnson Space Center. Photo credit: NASA

  4. STS-135 Press Conference

    NASA Image and Video Library

    2011-06-30

    JSC2011-E-060445 (30 June 2011) --- NASA astronaut Sandy Magnus, STS-135 mission specialist, responds to a question from a reporter during a preflight press conference at NASA's Johnson Space Center. Photo credit: NASA

  5. Expedition 52 Press Conference

    NASA Image and Video Library

    2017-07-10

    Expedition 52 flight engineer Paolo Nespoli of ESA answers a reporter's question during a crew press conference at the Gagarin Cosmonaut Training Center (GCTC), Monday, July 10, 2017 in Star City, Russia. Photo Credit: (NASA/Bill Ingalls)

  6. STS-134 Press Conference

    NASA Image and Video Library

    2011-03-24

    JSC2011-E-028492 (24 March 2011) --- NASA astronaut Greg Chamitoff, STS-134 mission specialist, fields a question from a reporter during a preflight press conference at NASA's Johnson Space Center. Photo credit: NASA or National Aeronautics and Space Administration

  7. STS-135 Press Conference

    NASA Image and Video Library

    2011-06-30

    JSC2011-E-060413 (30 June 2011) --- NASA astronaut Chris Ferguson, STS-135 commander, responds to a question from a reporter during a preflight press conference at NASA's Johnson Space Center. Photo credit: NASA

  8. Lunar & Planetary Science Conference.

    ERIC Educational Resources Information Center

    Warner, Jeffrey L.; And Others

    1982-01-01

    Summaries of different topics discussed at the Lunar and Planetary Science Conference are presented to provide updated information to nonplanetologists. Some topics include Venus, isotopes, chondrites, creation science, cosmic dust, cratering, moons and rings, igneous rocks, and lunar soil. (DC)

  9. Expedition 6 Press Conference

    NASA Image and Video Library

    2003-05-05

    Expedition 6 Commander Ken Bowersox, left and NASA International Space Station Science Officer Don Pettit speak during a press conference at the Gagarin Cosmonaut Training Center in Star City, Russia, Thursday, May 6, 2003. Photo Credit: (NASA/Bill Ingalls)

  10. Expedition 6 Press Conference

    NASA Image and Video Library

    2003-05-05

    Expedition 6 International Space Station Science Officer Don Pettit speaks during a press conference at the Gagarin Cosmonaut Training Center in Star City, Russia, Thursday, May 6, 2003. Photo Credit: (NASA/Bill Ingalls)

  11. Lunar & Planetary Science Conference.

    ERIC Educational Resources Information Center

    Warner, Jeffrey L.; And Others

    1982-01-01

    Summaries of different topics discussed at the Lunar and Planetary Science Conference are presented to provide updated information to nonplanetologists. Some topics include Venus, isotopes, chondrites, creation science, cosmic dust, cratering, moons and rings, igneous rocks, and lunar soil. (DC)

  12. STS-132 press conference

    NASA Image and Video Library

    2010-05-03

    JSC2010-E-063790 (3 May 2010) --- NASA astronaut Garrett Reisman, STS-132 mission specialist, fields a question from a reporter during an STS-132 preflight press conference at NASA's Johnson Space Center.

  13. STS-132 press conference

    NASA Image and Video Library

    2010-05-03

    JSC2010-E-063807 (3 May 2010) --- NASA astronaut Mike Good, STS-132 mission specialist, responds to a question from a reporter during an STS-132 preflight press conference at NASA's Johnson Space Center.

  14. STS-131 press conference

    NASA Image and Video Library

    2010-03-09

    JSC2010-E-038795 (9 March 2010) --- NASA astronaut Stephanie Wilson, STS-131 mission specialist, fields a question from a reporter during an STS-131 preflight press conference at NASA's Johnson Space Center.

  15. STS-132 press conference

    NASA Image and Video Library

    2010-05-03

    JSC2010-E-063799 (3 May 2010) --- NASA astronaut Steve Bowen, STS-132 mission specialist, fields a question from a reporter during an STS-132 preflight press conference at NASA's Johnson Space Center.

  16. STS-132 press conference

    NASA Image and Video Library

    2010-05-03

    JSC2010-E-063808 (3 May 2010) --- NASA astronaut Garrett Reisman, STS-132 mission specialist, responds to a question from a reporter during an STS-132 preflight press conference at NASA's Johnson Space Center.

  17. STS-131 press conference

    NASA Image and Video Library

    2010-03-09

    JSC2010-E-038797 (9 March 2010) --- NASA astronaut Rick Mastracchio, STS-131 mission specialist, responds to a question from a reporter during an STS-131 preflight press conference at NASA's Johnson Space Center.

  18. STS-132 press conference

    NASA Image and Video Library

    2010-05-03

    JSC2010-E-063797 (3 May 2010) --- NASA astronaut Steve Bowen, STS-132 mission specialist, fields a question from a reporter during an STS-132 preflight press conference at NASA's Johnson Space Center.

  19. STS-131 press conference

    NASA Image and Video Library

    2010-03-09

    JSC2010-E-038794 (9 March 2010) --- NASA astronaut Alan Poindexter, STS-131 commander, responds to a question from a reporter during an STS-131 preflight press conference at NASA's Johnson Space Center.

  20. STS-135 Press Conference

    NASA Image and Video Library

    2011-06-30

    JSC2011-E-060439 (30 June 2011) --- NASA astronaut Chris Ferguson, STS-135 commander, responds to a question from a reporter during a preflight press conference at NASA's Johnson Space Center. Photo credit: NASA

  1. STS-131 press conference

    NASA Image and Video Library

    2010-03-09

    JSC2010-E-038799 (9 March 2010) --- NASA astronaut Clayton Anderson, STS-131 mission specialist, responds to a question from a reporter during an STS-131 preflight press conference at NASA's Johnson Space Center.

  2. Expedition 19 Press Conference

    NASA Image and Video Library

    2009-03-24

    Expedition 19 Flight Engineer Michael R. Barratt smiles at his family from a quarantined glass room after a press conference on Wednesday, March 25, 2009 at the Cosmonaut Hotel in Baikonur, Kazakhstan. Photo Credit: (NASA/Bill Ingalls)

  3. Insider conference tips

    NASA Astrophysics Data System (ADS)

    Tennant, Jill

    2012-01-01

    Attending an educator conference and its associated exhibit hall can be a rewarding experience for your brain. But if you keep in mind these insider's tips, your feet, arms, stomach, and wallet will also thank you.

  4. National COPD conference summary.

    PubMed

    Buist, A Sonia; Bailey, William; Hurd, Suzanne S

    2004-01-01

    The first National COPD Conference, sponsored by the US COPD Coalition was held in Arlington, Virginia on November 14-15, 2003. The theme for the conference was developed around the Department of Health and Human Services (DHHS) Healthy People 2010 goals for COPD and included plenary speeches, roundtable discussions, abstracts, and workshops on spirometry, patient/physician education materials, and home monitoring/telemetry. The goal was to bring together a multidisciplinary group to identify important issues relating to COPD in the United States, specifically the barriers to a wider recognition of the disease, and to develop an orchestrated action plan. Over 500 scientists, clinicians, respiratory therapists, nurses, patients, government officials, and representatives from pharmaceutical companies participated. This summary provides the recommendations from the conference that will be used to develop an action plan for the US COPD Coalition. It includes actions proposed by plenary speakers, roundtable faculty and conference participants.

  5. Tackling conference carbon footprints

    NASA Astrophysics Data System (ADS)

    Grozier, Jim

    2016-12-01

    In reply to Margaret Harris's Lateral Thoughts article "Putting my foot down", which discussed the challenges of attending a conference with a physical disability (October p76) and a subsequent letter by Anna Wood (November p18).

  6. DNA sequencing conference, 2

    SciTech Connect

    Cook-Deegan, R.M.; Venter, J.C.; Gilbert, W.; Mulligan, J.; Mansfield, B.K.

    1991-06-19

    This conference focused on DNA sequencing, genetic linkage mapping, physical mapping, informatics and bioethics. Several were used to study this sequencing and mapping. This article also discusses computer hardware and software aiding in the mapping of genes.

  7. EPOXI Mission Press Conference

    NASA Image and Video Library

    2010-11-18

    Michael A'Hearn, EPOXI Principal Investigator, University of Maryland, holds a plastic bottle containing ice to illustrate a point during a press conference, Thursday, Nov. 18, 2010, at NASA Headquarters in Washington. The press conference was held to discuss the Nov. 4 successful flyby of Comet Hartley 2 by NASA's EPOXI Mission Spacecraft. Images from the flyby provided scientists the most extensive observations of a comet in history. Photo Credit: (NASA/Paul E. Alers)

  8. EPOXI Mission Press Conference

    NASA Image and Video Library

    2010-11-18

    Dr. James Green, Director of Planetary Science, NASA Headquarters, at podium, speaks during a press conference, Thursday, Nov. 18, 2010, at NASA Headquarters in Washington. The press conference was held to discuss the Nov. 4 successful flyby of Comet Hartley 2 by NASA's EPOXI Mission Spacecraft. Images from the flyby provided scientists the most extensive observations of a comet in history. Photo Credit: (NASA/Paul E. Alers)

  9. Multiphoton processes: conference proceedings

    SciTech Connect

    Lambropoulos, P.; Smith, S.J.

    1984-01-01

    The chapters of this volume represent the invited papers delivered at the conference. They are arranged according to thermatic proximity beginning with atoms and continuing with molecules and surfaces. Section headings include multiphoton processes in atoms, field fluctuations and collisions in multiphoton process, and multiphoton processes in molecules and surfaces. Abstracts of individual items from the conference were prepared separately for the data base. (GHT)

  10. Conference scene: DGVS spring conference 2009.

    PubMed

    Kolligs, Frank Thomas

    2009-10-01

    The 3rd annual DGVS Spring Conference of the German Society for Gastroenterology (Deutsche Gesellschaft für Verdauungs- und Stoffwechselkrankheiten) was held at the Seminaris Campus Hotel in Berlin, Germany, on 8-9 May, 2009. The conference was organized by Roland Schmid and Matthias Ebert from the Technical University of Munich, Germany. The central theme of the meeting was 'translational gastrointestinal oncology: towards personalized medicine and individualized therapy'. The conference covered talks on markers for diagnosis, screening and surveillance of colorectal cancer, targets for molecular therapy, response prediction in clinical oncology, development and integration of molecular imaging in gastrointestinal oncology and translational research in clinical trial design. Owing to the broad array of topics and limitations of space, this article will focus on biomarkers, response prediction and the integration of biomarkers into clinical trials. Presentations mentioned in this summary were given by Matthias Ebert (Technical University of Munich, Germany), Esmeralda Heiden (Epigenomics, Berlin, Germany), Frank Kolligs (University of Munich, Germany), Florian Lordick (University of Heidelberg, Germany), Hans Jorgen Nielsen (University of Copenhagen, Denmark), Anke Reinacher-Schick (University of Bochum, Germany), Christoph Röcken (University of Berlin, Germany), Wolff Schmiegel (University of Bochum, Germany) and Thomas Seufferlein (University of Halle, Germany).

  11. Pathways, Networks and Systems Medicine Conferences

    SciTech Connect

    Nadeau, Joseph H.

    2013-11-25

    The 6th Pathways, Networks and Systems Medicine Conference was held at the Minoa Palace Conference Center, Chania, Crete, Greece (16-21 June 2008). The Organizing Committee was composed of Joe Nadeau (CWRU, Cleveland), Rudi Balling (German Research Centre, Brauschweig), David Galas (Institute for Systems Biology, Seattle), Lee Hood (Institute for Systems Biology, Seattle), Diane Isonaka (Seattle), Fotis Kafatos (Imperial College, London), John Lambris (Univ. Pennsylvania, Philadelphia),Harris Lewin (Univ. of Indiana, Urbana-Champaign), Edison Liu (Genome Institute of Singapore, Singapore), and Shankar Subramaniam (Univ. California, San Diego). A total of 101 individuals from 21 countries participated in the conference: USA (48), Canada (5), France (5), Austria (4), Germany (3), Italy (3), UK (3), Greece (2), New Zealand (2), Singapore (2), Argentina (1), Australia (1), Cuba (1), Denmark (1), Japan (1), Mexico (1), Netherlands (1), Spain (1), Sweden (1), Switzerland (1). With respect to speakers, 29 were established faculty members and 13 were graduate students or postdoctoral fellows. With respect to gender representation, among speakers, 13 were female and 28 were male, and among all participants 43 were female and 58 were male. Program these included the following topics: Cancer Pathways and Networks (Day 1), Metabolic Disease Networks (Day 2), Day 3 ? Organs, Pathways and Stem Cells (Day 3), and Day 4 ? Inflammation, Immunity, Microbes and the Environment (Day 4). Proceedings of the Conference were not published.

  12. Nuclear Rocket Technology Conference

    NASA Technical Reports Server (NTRS)

    1966-01-01

    The Lewis Research Center has a strong interest in nuclear rocket propulsion and provides active support of the graphite reactor program in such nonnuclear areas as cryogenics, two-phase flow, propellant heating, fluid systems, heat transfer, nozzle cooling, nozzle design, pumps, turbines, and startup and control problems. A parallel effort has also been expended to evaluate the engineering feasibility of a nuclear rocket reactor using tungsten-matrix fuel elements and water as the moderator. Both of these efforts have resulted in significant contributions to nuclear rocket technology. Many successful static firings of nuclear rockets have been made with graphite-core reactors. Sufficient information has also been accumulated to permit a reasonable Judgment as to the feasibility of the tungsten water-moderated reactor concept. We therefore consider that this technoIogy conference on the nuclear rocket work that has been sponsored by the Lewis Research Center is timely. The conference has been prepared by NASA personnel, but the information presented includes substantial contributions from both NASA and AEC contractors. The conference excludes from consideration the many possible mission requirements for nuclear rockets. Also excluded is the direct comparison of nuclear rocket types with each other or with other modes of propulsion. The graphite reactor support work presented on the first day of the conference was partly inspired through a close cooperative effort between the Cleveland extension of the Space Nuclear Propulsion Office (headed by Robert W. Schroeder) and the Lewis Research Center. Much of this effort was supervised by Mr. John C. Sanders, chairman for the first day of the conference, and by Mr. Hugh M. Henneberry. The tungsten water-moderated reactor concept was initiated at Lewis by Mr. Frank E. Rom and his coworkers. The supervision of the recent engineering studies has been shared by Mr. Samuel J. Kaufman, chairman for the second day of the

  13. Conference on multicellular and interactive behavior of bacteria

    SciTech Connect

    Not Available

    1994-11-01

    This document provides abstracts for oral presentations at an American Society of Microbiology Conference on Multicellular and interactive behavior of bacteria. Sessions included: Cell to Cell interactions and exchange of genetic material; symbiotic interactions; multicellular aspects of pathogenesis; multicellular motility; developmental interactions; metabolic interactions; interactions in biofilms and surface colonization; pattern formation and colonial interactions.

  14. ADMET--Fifth Annual SMi Conference.

    PubMed

    Comer, John E

    2010-09-01

    SMi's fifth annual ADMET Conference, held in London, included topics covering new developments in the field of ADMET. This conference report highlights selected presentations on ADME optimization in drug discovery; targeting drugs to the brain; predicting bonds that might be attacked during metabolism; treating Caco-2 membranes with vinblastine to enhance P-glycoprotein interactions; predictive ADMET in hit-to-lead optimization; structure-based studies of ADMET targets; an accelerated process for integrated drug development; building hypotheses in lead selection and optimization; supersaturation effects; the prediction of drug-drug interactions; developing a mechanism-based pharmacokinetic/pharmacodynamic model; drug transporter assays in drug discovery; time-dependent inhibition screens in early drug discovery; the system-dependent inhibition of CYP enzymes; the integrating predictive toxicology framework OpenTox; high-content analysis for predictive cytotoxicity testing; and emerging in vitro toxicity assays.

  15. Surfactant phospholipid metabolism

    PubMed Central

    Agassandian, Marianna; Mallampalli, Rama K.

    2012-01-01

    Pulmonary surfactant is essential for life and is comprised of a complex lipoprotein-like mixture that lines the inner surface of the lung to prevent alveolar collapse at the end of expiration. The molecular composition of surfactant depends on highly integrated and regulated processes involving its biosynthesis, remodeling, degradation, and intracellular trafficking. Despite its multicomponent composition, the study of surfactant phospholipid metabolism has focused on two predominant components, disaturated phosphatidylcholine that confers surface-tension lowering activities, and phosphatidylglycerol, recently implicated in innate immune defense. Future studies providing a better understanding of the molecular control and physiological relevance of minor surfactant lipid components are needed. PMID:23026158

  16. Molecular Basis of Microbial One-Carbon Metabolism

    SciTech Connect

    2002-07-12

    The Gordon Research Conference (GRC) on Molecular Basis of Microbial One-Carbon Metabolism was held at Connecticut College, New London, Connecticut. Emphasis was placed on current unpublished research and discussion of the future target areas in this field.

  17. 10 CFR 501.32 - Conferences (other than prepetition conferences).

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Conferences (other than prepetition conferences). 501.32 Section 501.32 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS ADMINISTRATIVE PROCEDURES AND SANCTIONS Written Comments, Public Hearings and Conferences During Administrative Proceedings § 501.32...

  18. 10 CFR 501.32 - Conferences (other than prepetition conferences).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Conferences (other than prepetition conferences). 501.32 Section 501.32 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS ADMINISTRATIVE PROCEDURES AND SANCTIONS Written Comments, Public Hearings and Conferences During Administrative Proceedings § 501.32...

  19. 10 CFR 501.32 - Conferences (other than prepetition conferences).

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Conferences (other than prepetition conferences). 501.32 Section 501.32 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS ADMINISTRATIVE PROCEDURES AND SANCTIONS Written Comments, Public Hearings and Conferences During Administrative Proceedings § 501.32...

  20. 10 CFR 501.32 - Conferences (other than prepetition conferences).

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Conferences (other than prepetition conferences). 501.32 Section 501.32 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS ADMINISTRATIVE PROCEDURES AND SANCTIONS Written Comments, Public Hearings and Conferences During Administrative Proceedings § 501.32...

  1. 10 CFR 501.32 - Conferences (other than prepetition conferences).

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Conferences (other than prepetition conferences). 501.32 Section 501.32 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS ADMINISTRATIVE PROCEDURES AND SANCTIONS Written Comments, Public Hearings and Conferences During Administrative Proceedings § 501.32...

  2. 78 FR 27963 - Reliability Technical Conference; Notice of Technical Conference

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Reliability Technical Conference; Notice of Technical Conference Take notice that the Federal Energy Regulatory Commission will hold a Technical Conference on Tuesday, July 9,...

  3. ARC Conference Showcases Telecommunications Services.

    ERIC Educational Resources Information Center

    Baldwin, Fred D.

    1996-01-01

    The Appalachian Regional Commission's 1996 Conference, "Building Blocks for Using Telecommunications and Information Technology," held in Binghamton, New York, focused on the role of telecommunications in Appalachia in education and training, telemedicine, business, and government. Highlights conference presentations on special…

  4. ARC Conference Showcases Telecommunications Services.

    ERIC Educational Resources Information Center

    Baldwin, Fred D.

    1996-01-01

    The Appalachian Regional Commission's 1996 Conference, "Building Blocks for Using Telecommunications and Information Technology," held in Binghamton, New York, focused on the role of telecommunications in Appalachia in education and training, telemedicine, business, and government. Highlights conference presentations on special…

  5. Turbomachinery controls conference (TCC) 1995

    SciTech Connect

    1995-09-01

    The proceedings of the Turbomachinery Controls Conference 1995 are presented. Eleven papers were presented at the conference. A separate abstract was prepared for each of the nine papers for inclusion in the Energy Science and Technology Database.

  6. Twitter use in physics conferences.

    PubMed

    Webb, Stephen

    An analysis of Twitter use in 116 conferences suggests that the service is used more extensively at PACS10 conferences (those devoted to the physics of elementary particles and fields) and PACS90 conferences (those devoted to geophysics, astronomy, and astrophysics) than at conferences in other fields of physics. Furthermore, Twitter is used in a qualitatively different manner. A possible reason for these differences is discussed.

  7. Conducting Telephone Conference IEPs

    ERIC Educational Resources Information Center

    Patterson, Philip Patrick; Petit, Constance; Williams, Shandelyn

    2007-01-01

    Synchronizing the availability of team members for Individual Education Plan (IEP) meetings can be a daunting task. Fortunately, the Individuals with Disabilities Education Improvement Act of 2004 permits alternative means of conducting such meetings. An example of an alternate means is a telephone conference, whereby parents communicate over the…

  8. REGIONAL CONFERENCE SUMMARIES, 1966.

    ERIC Educational Resources Information Center

    Bureau of Adult, Vocational, and Technical Education (DHEW/OE), Washington, DC. Div. of Vocational and Technical Education.

    AN AVERAGE OF 200 TEACHER EDUCATORS, STATE DIRECTORS, LAYMEN, AND REPRESENTATIVES OF VARIOUS AGENCIES ATTENDED EACH OF NINE REGIONAL CONFERENCES CONDUCTED THROUGHOUT THE UNITED STATES TO DISCUSS THE INFLUENCE OF SOCIAL AND ECONOMIC CHANGES AND PROBLEMS IN PLANNING AND CONDUCTING VOCATIONAL AND TECHNICAL EDUCATION PROGRAMS. MAJOR SPEECHES PRESENTED…

  9. Open Mind Conference

    NASA Technical Reports Server (NTRS)

    King, Alexander H.

    1995-01-01

    Open Mind, The Association for the achievement of diversity in higher education, met in conference in Albuquerque, New Mexico, between October 16 and 18, 1992. A number of workgroups met to discuss the goals, structure, and generally evaluate the Association and its achievements. A summary of the workgroup sessions and their minutes are included.

  10. The interparliamentary conference

    SciTech Connect

    Not Available

    1990-01-01

    The purpose of this conference was to provide a forum for exchange of information on environmental problems with global origins and consequences. The areas of major concern included the following: global climate change; deforestation and desertification; preservation of biological diversity; safeguarding oceans and water resources; population growth; destruction of the stratospheric ozone layer; and sustainable development.

  11. Press Conference - Skylab 3

    NASA Image and Video Library

    1972-08-14

    S72-46699 (19 Jan. 1972) --- Prime crew members of the scheduled second Skylab mission are introduced to the media during a press conference in January 1972 at the Manned Spacecraft Center (MSC). From left to right are astronauts Jack R. Lousma, pilot; Owen K. Garriott, science pilot, and Alan L. Bean, commander. Photo credit: NASA

  12. Creating Better Satellite Conferences.

    ERIC Educational Resources Information Center

    Horner, Tommy

    1998-01-01

    Presents four ways to improve broadcasts of company satellite conferences, including creative site selection (using facilities at educational institutions rather than hotel rooms); creative programming (using graphics and other interruptions to break up lectures or speeches); creative crew selection; and creative downlink site activities (to…

  13. Government Quality Conference Proceedings

    NASA Technical Reports Server (NTRS)

    1992-01-01

    The Government Quality Conference was an attempt to bring together executive organizations and senior individuals in the Federal Government that have a desire to improve productivity. It was designed to provide an exchange of ideas based on experience, and to encourage individual management initiatives to tap the capabilities of Federal employees.

  14. STS-134 Press Conference

    NASA Image and Video Library

    2011-03-24

    JSC2011-E-028491 (24 March 2011) --- European Space Agency astronaut Roberto Vittori, STS-134 mission specialist, fields a question from a reporter during a preflight press conference at NASA's Johnson Space Center. Photo credit: NASA or National Aeronautics and Space Administration

  15. STS-134 Press Conference

    NASA Image and Video Library

    2011-03-24

    JSC2011-E-028498 (24 March 2011) --- European Space Agency astronaut Roberto Vittori, STS-134 mission specialist, responds to a question from a reporter during a preflight press conference at NASA's Johnson Space Center. Photo credit: NASA or National Aeronautics and Space Administration

  16. Expedition 34 Press Conference

    NASA Image and Video Library

    2012-12-18

    Russian backup crew member Fyodor Yurchikin, right, answers a reporter's question at a press conference held at the Cosmonaut Hotel, on Tuesday, Dec. 18, 2012, in Baikonur, Kazakhstan. Seen next to him are NASA backup crew member Karen Nyberg and Expedition 34/35 Canadian Space Agency astronaut Chris Hadfield. Photo Credit: (NASA/Carla Cioffi)

  17. STS-134 Press Conference

    NASA Image and Video Library

    2011-03-24

    JSC2011-E-028488 (24 March 2011) --- NASA astronaut Greg H. Johnson, STS-134 pilot, responds to a question from a reporter during a preflight press conference at NASA's Johnson Space Center. Photo credit: NASA or National Aeronautics and Space Administration

  18. STS-134 Press Conference

    NASA Image and Video Library

    2011-03-24

    JSC2011-E-028490 (24 March 2011) --- NASA astronaut Michael Fincke, STS-134 mission specialist, responds to a question from a reporter during a preflight press conference at NASA's Johnson Space Center. Photo credit: NASA or National Aeronautics and Space Administration

  19. STS-134 Press Conference

    NASA Image and Video Library

    2011-03-24

    JSC2011-E-028496 (24 March 2011) --- NASA astronaut Andrew Feustel, STS-134 mission specialist, responds to a question from a reporter during a preflight press conference at NASA's Johnson Space Center. Photo credit: NASA or National Aeronautics and Space Administration

  20. Microbicides 2006 conference

    PubMed Central

    Ramjee, Gita; Shattock, Robin; Delany, Sinead; McGowan, Ian; Morar, Neetha; Gottemoeller, Megan

    2006-01-01

    Current HIV/AIDS statistics show that women account for almost 60% of HIV infections in Sub-Saharan Africa. HIV prevention tools such as male and female condoms, abstinence and monogamy are not always feasible options for women due to various socio-economic and cultural factors. Microbicides are products designed to be inserted in the vagina or rectum prior to sex to prevent HIV acquisition. The biannual Microbicides conference took place in Cape Town, South Africa from 23–26 April 2006. The conference was held for the first time on the African continent, the region worst affected by the HIV/AIDS pandemic. The conference brought together a record number of 1,300 scientists, researchers, policy makers, healthcare workers, communities and advocates. The conference provided an opportunity for an update on microbicide research and development as well as discussions around key issues such as ethics, acceptability, access and community involvement. This report discusses the current status of microbicide research and development, encompassing basic and clinical science, social and behavioural science, and community mobilisation and advocacy activities. PMID:17038196

  1. Effective Parent Conferences

    ERIC Educational Resources Information Center

    Elmore, Michael

    2008-01-01

    Conferences with an upset parent, teacher, or student should be opportunities for schools to build relationships with the community and to foster a positive school culture. But in reality, they are often held because a problem has arisen and often end with stakeholders having a less-than-positive image of the school. Understanding the steps that…

  2. Conference on Censorship.

    ERIC Educational Resources Information Center

    Meltzer, Milton; And Others

    In this collection of seven speeches from the University of Missouri Conference on Censorship, writers focus on the various aspects of censorship. Speeches are by (1) Milton Meltzer, who lauds those writers who were forced to battle with censors; (2) Enid Olson, who explores the censorship problems faced by teachers and school librarians; (3)…

  3. APPA 2011 Conference Highlights

    ERIC Educational Resources Information Center

    Facilities Manager, 2011

    2011-01-01

    This article presents highlights of APPA conference that was held on July 16-18, 2011. The highlights feature photos of 2011-2012 board of directors, outgoing senior regional representatives to the board, meritorious service award, APPA fellow, president's recognition and gavel exchange, and diamond business partner award.

  4. Expedition 28 Press Conference

    NASA Image and Video Library

    2011-06-06

    Expedition 28 NASA Flight Engineer Mike Fossum, left, and Soyuz Commander Sergei Volkov of Russia share a laugh during a press conference, Monday, June 6, 2011, at the Cosmonaut Hotel in Baikonur, Kazakhstan. The mission is set to launch on Tuesday, June 8, from the Baikonur Cosmodrome. Photo Credit: (NASA/Carla Cioffi)

  5. Expedition 29 Press Conference

    NASA Image and Video Library

    2011-11-12

    Expedition 29 Soyuz Commander Anton Shkaplerov answers a reporter’s question during a press conference held at the Cosmonaut Hotel in Baikonur, Kazakhstan on Saturday, Nov. 12, 2011. The mission is set to launch November 14 from the Baikonur Cosmodrome. Photo Credit: (NASA/Carla Cioffi)

  6. Expedition 28 Press Conference

    NASA Image and Video Library

    2011-06-06

    Expedition 28 NASA Flight Engineer Mike Fossum, speaks during a press conference, Monday, June 6, 2011, at the Cosmonaut Hotel in Baikonur, Kazakhstan. The mission is set to launch on Tuesday, June 8, from the Baikonur Cosmodrome. Photo Credit: (NASA/Carla Cioffi)

  7. Expedition 28 Press Conference

    NASA Image and Video Library

    2011-06-06

    Expedition 28 NASA Flight Engineer Mike Fossum speaks during a press conference, Monday, June 6, 2011, at the Cosmonaut Hotel in Baikonur, Kazakhstan. The mission is set to launch on Tuesday, June 8, from the Baikonur Cosmodrome. Photo Credit: (NASA/Carla Cioffi)

  8. Expedition 28 Press Conference

    NASA Image and Video Library

    2011-06-06

    Expedition 28 NASA Flight Engineer Mike Fossum, left, and Soyuz Commander Sergei Volkov of Russia are seen during a press conference, Monday, June 6, 2011, at the Cosmonaut Hotel in Baikonur, Kazakhstan. The mission is set to launch on Tuesday, June 8, from the Baikonur Cosmodrome. Photo Credit: (NASA/Carla Cioffi)

  9. Expedition 29 Press Conference

    NASA Image and Video Library

    2011-11-12

    Expedition 29 backup crew members NASA Flight Engineer Joseph Acaba, far left, Russian Soyuz Commander Gennady Padalka, center, and Russian Flight Engineer Sergei Revin are seen at a press conference held at the Cosmonaut Hotel in Baikonur, Kazakhstan on Saturday, Nov. 12, 2011. Photo Credit: (NASA/Carla Cioffi)

  10. Expedition 29 Press Conference

    NASA Image and Video Library

    2011-11-12

    Expedition 29 NASA Flight Engineer Dan Burbank answers a reporter’s question during a press conference held at the Cosmonaut Hotel in Baikonur, Kazakhstan on Saturday, Nov. 12, 2011. The launch of the Soyuz spacecraft with Expedition 29 NASA Flight Engineer Dan Burbank, Soyuz Commander Anton Shkaplerov and Flight Engineer Anatoly Ivanishin is scheduled for November 14. Photo Credit: (NASA/Carla Cioffi)

  11. Expedition 28 Press Conference

    NASA Image and Video Library

    2011-06-06

    Expedition 28 NASA backup Flight Engineer Don Pettit looks on during a press conference, Monday, June 6, 2011, at the Cosmonaut Hotel in Baikonur, Kazakhstan. The mission is set to launch on Tuesday, June 8, from the Baikonur Cosmodrome. Photo Credit: (NASA/Carla Cioffi)

  12. Expedition 28 Press Conference

    NASA Image and Video Library

    2011-06-06

    Expedition 28 Soyuz Commander Sergei Volkov of Russia speaks during a press conference, Monday, June 6, 2011, at the Cosmonaut Hotel in Baikonur, Kazakhstan. The mission is set to launch on Tuesday, June 7, from the Baikonur Cosmodrome. Photo Credit: (NASA/Carla Cioffi)

  13. Expedition 29 Press Conference

    NASA Image and Video Library

    2011-11-12

    Expedition 29 NASA backup crew member Joe Acaba is seen at a press conference held at the Cosmonaut Hotel, Saturday, Nov. 12, 2011 at the Cosmonaut Hotel in Baikonur, Kazakhstan. The mission is set to launch November 14 from the Baikonur Cosmodrome. Photo Credit: (NASA/Carla Cioffi)

  14. Expedition 28 Press Conference

    NASA Image and Video Library

    2011-06-06

    NASA backup Flight Engineer Don Pettit speaks during a press conference, Monday, June 6, 2011, at the Cosmonaut Hotel in Baikonur, Kazakhstan. The mission is set to launch on Tuesday, June 8, from the Baikonur Cosmodrome. Photo Credit: (NASA/Carla Cioffi)

  15. Expedition 28 Press Conference

    NASA Image and Video Library

    2011-06-06

    Expedition 28 Soyuz Commander Sergei Volkov speaks during a press conference, Monday, June 6, 2011, at the Cosmonaut Hotel in Baikonur, Kazakhstan. The mission is set to launch on Tuesday, June 8, from the Baikonur Cosmodrome. Photo Credit: (NASA/Carla Cioffi)

  16. Expedition 39 Press Conference

    NASA Image and Video Library

    2014-03-24

    Expedition 39 flight engineer Steve Swanson of NASA is seen in quarantine, behind glass, during the final press conference be Monday, March 24, 2014, at the Cosmonaut Hotel in Baikonur, Kazakhstan. The mission to the International Space Station is set to launch March 26 from the Baikonur Cosmodrome. Photo Credit: (NASA/Bill Ingalls)

  17. Expedition 28 Press Conference

    NASA Image and Video Library

    2011-06-06

    Russian backup Flight Engineer Oleg Kononenko speaks during a press conference, Monday, June 6, 2011, at the Cosmonaut Hotel in Baikonur, Kazakhstan. The mission is set to launch on Tuesday, June 8, from the Baikonur Cosmodrome. Photo Credit: (NASA/Carla Cioffi)

  18. Expedition 29 Press Conference

    NASA Image and Video Library

    2011-11-12

    Expedition 29 backup crew members Joseph Acaba, left, and Russian Flight Engineer Gennady Padalka share a few words during a press conference held at the Cosmonaut Hotel in Baikonur, Kazakhstan on Saturday, Nov. 12, 2011. Photo Credit: (NASA/Carla Cioffi)

  19. Expedition 29 Press Conference

    NASA Image and Video Library

    2011-11-12

    Expedition 29 Flight Engineer Anatoly Ivanishin is seen at a press conference held at the Cosmonaut Hotel, Saturday, Nov. 12, 2011 at the Cosmonaut Hotel in Baikonur, Kazakhstan. The mission is set to launch November 14 from the Baikonur Cosmodrome. Photo Credit: (NASA/Carla Cioffi)

  20. Expedition 40 Press Conference

    NASA Image and Video Library

    2014-05-27

    A man taking a picture with a cell phone is seen reflected in the glass separating the quarantined crew during a press conference on Tuesday, May 27, 2014, at the Cosmonaut Hotel in Baikonur, Kazakhstan. The mission to the International Space Station is set to launch May 29 from the Baikonur Cosmodrome. Photo Credit: (NASA/Joel Kowsky)

  1. Expedition 29 Press Conference

    NASA Image and Video Library

    2011-11-12

    Expedition 29 Russian Flight Engineer Anatoly Ivanishin answers a reporter’s question during a press conference held at the Cosmonaut Hotel in Baikonur, Kazakhstan on Saturday, Nov. 12, 2011. The launch of the Soyuz spacecraft with Ivanishin, Soyuz Commander Anton Shkaplerov and NASA Flight Engineer Dan Burbank is scheduled for November 14. Photo Credit: (NASA/Carla Cioffi)

  2. Expedition 28 Press Conference

    NASA Image and Video Library

    2011-06-06

    Expedition 28 NASA Flight Engineer Mike Fossum, left, looks on as Soyuz Commander Sergei Volkov speaks during a press conference, Monday, June 6, 2011, at the Cosmonaut Hotel in Baikonur, Kazakhstan. The mission is set to launch on Tuesday, June 8, from the Baikonur Cosmodrome. Photo Credit: (NASA/Carla Cioffi)

  3. Expedition 41 Press Conference

    NASA Image and Video Library

    2014-09-24

    NASA Expedition 41 backup crew member Flight Engineer Mikhail Kornienko of the Russian Federal Space Agency (Roscosmos) answers a question during a press conference Wednesday, Sept. 24, 2014 at the Cosmonaut Hotel in Baikonur, Kazakhstan. The prime crew is set to launch Sept. 26 from the Baikonur Cosmodrome. Photo Credit: (NASA/Aubrey Gemignani)

  4. Annual Conference Abstracts

    ERIC Educational Resources Information Center

    Journal of Engineering Education, 1972

    1972-01-01

    Includes abstracts of papers presented at the 80th Annual Conference of the American Society for Engineering Education. The broad areas include aerospace, affiliate and associate member council, agricultural engineering, biomedical engineering, continuing engineering studies, chemical engineering, civil engineering, computers, cooperative…

  5. Conference summary - Personal views

    NASA Astrophysics Data System (ADS)

    Lub, J.

    2016-05-01

    This is a collection of remarks on the three and a half days of the RR Lyrae 2015 Conference, limited only by my own lack of attention and understanding. I end with some personal recollections on my complete failure, even though doing the necessary calculations, to spot the importance and the possible application of Fourier amplitudes and phases of the RR Lyrae light curves.

  6. Grammar! A Conference Report.

    ERIC Educational Resources Information Center

    King, Lid, Ed.; Boaks, Peter, Ed.

    Papers from a conference on the teaching of grammar, particularly in second language instruction, include: "Grammar: Acquisition and Use" (Richard Johnstone); "Grammar and Communication" (Brian Page); "Linguistic Progression and Increasing Independence" (Bernardette Holmes); "La grammaire? C'est du bricolage!" ("Grammar? That's Hardware!") (Barry…

  7. 2008 Combat Vehicles Conference

    DTIC Science & Technology

    2008-10-22

    General Michael M. Brogan Combat Vehicles Conference Marine Corps Systems Command 21 October 2008 2 MCSC •LAV •AAV •Tank •HMMWV/ ECV •MRAP PEO LS...34,226 Total 56,649 1985 IOC 1996 M1114 armored HMMWV Limited Production 2006 M1100 series begins fielding scalable armor 2009-10 ECV II

  8. Annual Conference Abstracts

    ERIC Educational Resources Information Center

    Journal of Engineering Education, 1972

    1972-01-01

    Includes abstracts of papers presented at the 80th Annual Conference of the American Society for Engineering Education. The broad areas include aerospace, affiliate and associate member council, agricultural engineering, biomedical engineering, continuing engineering studies, chemical engineering, civil engineering, computers, cooperative…

  9. Expedition 6 Press Conference

    NASA Image and Video Library

    2003-05-05

    Expedition 6 Flight Engineer Nikolai Budarin, left, Commander Ken Bowersox and International Space Station Science Officer Don Pettit, right, pose for photos at a press conference at the Gagarin Cosmonaut Training Center in Star City, Russia, Thursday, May 6, 2003. Photo Credit: (NASA/Bill Ingalls)

  10. Expedition 6 Press Conference

    NASA Image and Video Library

    2003-05-05

    Expedition 6 Flight Engineer Nikolai Budarin, left, Commander Ken Bowersox and NASA International Space Station Science Officer Don Pettit, right, answer questions during a press conference at the Gagarin Cosmonaut Training Center in Star City, Russia, Thursday, May 6, 2003. Photo Credit: (NASA/Bill Ingalls)

  11. Constellation Program Press Conference

    NASA Image and Video Library

    2006-06-04

    NASA Administrator Michael Griffin, left, Scott Horowitz, NASA Associate Administrator for Exploration Systems and Jeff Hanley, Constellation Program Manager, right, are seen during a press conference outlining specific center responsibilities associated with the Constellation Program for robotic and human Moon and Mars exploration, Monday, June 5, 2006, at NASA Headquarters in Washington. Photo Credit (NASA/Bill Ingalls)

  12. Constellation Program Press Conference

    NASA Image and Video Library

    2006-06-04

    Scott Horowitz, NASA Associate Administrator for Exploration Systems, center, speaks as Jeff Hanley, Constellation Program Manager, right, looks on during a press conference outlining specific center responsibilities associated with the Constellation Program for robotic and human Moon and Mars exploration, Monday, June 5, 2006, at NASA Headquarters in Washington. Photo Credit (NASA/Bill Ingalls)

  13. Hydrogen Conference: Workshop Proceedings

    SciTech Connect

    1989-10-01

    Hydrogen is currently a major chemical/fuel with long-term energy system benefits that may impact the industry's physical and economic well-being. EPRI's recent hydrogen conference concluded that to be competitive, the production cost must take into account environmental and end-use efficiency benefits.

  14. Google Moon Press Conference

    NASA Image and Video Library

    2009-07-19

    Andrew Chaikin, author of "A Man on the Moon" speaks during a press conference, Monday, July 20, 2009, announcing the launch of Moon in Google Earth, an immersive 3D atlas of the Moon, accessible within Google Earth 5.0, Monday, July 20, 2009, at the Newseum in Washington. Photo Credit: (NASA/Bill Ingalls)

  15. Google Moon Press Conference

    NASA Image and Video Library

    2009-07-19

    Buzz Aldrin, the second man to walk on the moon, speaks during a press conference, Monday, July 20, 2009, announcing the launch of Moon in Google Earth, an immersive 3D atlas of the Moon, accessible within Google Earth 5.0, Monday, July 20, 2009, at the Newseum in Washington. Photo Credit: (NASA/Bill Ingalls)

  16. Google Moon Press Conference

    NASA Image and Video Library

    2009-07-19

    Apollo 11 astronaut Buzz Aldrin, the second man to walk on the Moon, speaks during a press conference, Monday, July 20, 2009, announcing the launch of Moon in Google Earth, an immersive 3D atlas of the Moon, accessible within Google Earth 5.0, Monday, July 20, 2009, at the Newseum in Washington. Photo Credit: (NASA/Bill Ingalls)

  17. Google Moon Press Conference

    NASA Image and Video Library

    2009-07-19

    NASA Deputy Administrator Lori Garver, speaks during a press conference, Monday, July 20, 2009, announcing the launch of Moon in Google Earth, an immersive 3D atlas of the Moon, accessible within Google Earth 5.0, Monday, July 20, 2009, at the Newseum in Washington. Photo Credit: (NASA/Bill Ingalls)

  18. Google Moon Press Conference

    NASA Image and Video Library

    2009-07-19

    Tiffany Montague, Technical Program Manager for NASA and Google Lunar X PRIZE, Google, Inc., speaks during a press conference, Monday, July 20, 2009, announcing the launch of Moon in Google Earth, an immersive 3D atlas of the Moon, accessible within Google Earth 5.0, Monday, July 20, 2009, at the Newseum in Washington. Photo Credit: (NASA/Bill Ingalls)

  19. Google Moon Press Conference

    NASA Image and Video Library

    2009-07-19

    Brian McLendon, VP of Engineering, Google, Inc., speaks during a press conference, Monday, July 20, 2009, announcing the launch of Moon in Google Earth, an immersive 3D atlas of the Moon, accessible within Google Earth 5.0, Monday, July 20, 2009, at the Newseum in Washington. Photo Credit: (NASA/Bill Ingalls)

  20. Google Moon Press Conference

    NASA Image and Video Library

    2009-07-19

    Yoshinori Yoshimura, a respresentative from the Japan Aerospace Exploration Agency (JAXA), speaks during a press conference, Monday, July 20, 2009, announcing the launch of Moon in Google Earth, an immersive 3D atlas of the Moon, accessible within Google Earth 5.0, Monday, July 20, 2009, at the Newseum in Washington. Photo Credit: (NASA/Bill Ingalls)

  1. Google Moon Press Conference

    NASA Image and Video Library

    2009-07-19

    Michael Weiss-Malik, Product Manager for Moon in Google Earth, Google, Inc., speaks during a press conference, Monday, July 20, 2009, announcing the launch of Moon in Google Earth, an immersive 3D atlas of the Moon, accessible within Google Earth 5.0, Monday, July 20, 2009, at the Newseum in Washington. Photo Credit: (NASA/Bill Ingalls)

  2. Google Moon Press Conference

    NASA Image and Video Library

    2009-07-19

    Miles O'Brien, former chief science and tech correspondent for CNN, speaks during a press conference, Monday, July 20, 2009, announcing the launch of Moon in Google Earth, an immersive 3D atlas of the Moon, accessible within Google Earth 5.0, Monday, July 20, 2009, at the Newseum in Washington. Photo Credit: (NASA/Bill Ingalls)

  3. Conference presentations with confidence.

    PubMed

    Strickland, T

    1999-01-01

    Remember that great presentation you heard at last year's convention? Perhaps the marketing case study was especially interesting. Or perhaps you wondered whether you could use the organizational tools the speaker described in your own work. Finally, you might have wondered, "Could I offer a conference presentation at some point?" The answer: yes!

  4. 2002 NASPSA Conference Abstracts.

    ERIC Educational Resources Information Center

    Journal of Sport & Exercise Psychology, 2002

    2002-01-01

    Contains abstracts from the 2002 conference of the North American Society for the Psychology of Sport and Physical Activity. The publication is divided into three sections: the preconference workshop, "Effective Teaching Methods in the Classroom;" symposia (motor development, motor learning and control, and sport psychology); and free…

  5. Annual Conference Abstracts

    ERIC Educational Resources Information Center

    Engineering Education, 1976

    1976-01-01

    Presents the abstracts of 158 papers presented at the American Society for Engineering Education's annual conference at Knoxville, Tennessee, June 14-17, 1976. Included are engineering topics covering education, aerospace, agriculture, biomedicine, chemistry, computers, electricity, acoustics, environment, mechanics, and women. (SL)

  6. 2002 NASPSA Conference Abstracts.

    ERIC Educational Resources Information Center

    Journal of Sport & Exercise Psychology, 2002

    2002-01-01

    Contains abstracts from the 2002 conference of the North American Society for the Psychology of Sport and Physical Activity. The publication is divided into three sections: the preconference workshop, "Effective Teaching Methods in the Classroom;" symposia (motor development, motor learning and control, and sport psychology); and free…

  7. Expedition 52 Press Conference

    NASA Image and Video Library

    2017-07-10

    Expedition 52 flight engineers Paolo Nespoli of ESA, left, Sergey Ryazanskiy of Roscosmos, center, and Expedition 52 flight engineer Randy Bresnik of NASA pose for group photograph at the conclusion of their crew press conference at the Gagarin Cosmonaut Training Center (GCTC), Monday, July 10, 2017 in Star City, Russia. Photo Credit: (NASA/Bill Ingalls)

  8. Expedition 50 Press Conference

    NASA Image and Video Library

    2016-10-26

    Expedition 50 NASA astronaut Peggy Whitson, left, Russian cosmonaut Oleg Novitskiy of Roscosmos, center, and ESA astronaut Thomas Pesquet pose for a group photograph at the conclusion of a press conference, Wednesday, Oct. 26, 2016, at the Gagarin Cosmonaut Training Center (GCTC) in Star City, Russia. Photo Credit: (NASA/Bill Ingalls)

  9. Expedition 52 Press Conference

    NASA Image and Video Library

    2017-07-10

    A painting of Yuri Gagarin is seen in the lobby of the building where the Expedition 52 prime and backup crews held a crew press conference on the grounds of the Gagarin Cosmonaut Training Center (GCTC), Monday, July 10, 2017 in Star City, Russia. Photo Credit: (NASA/Bill Ingalls)

  10. DEVELOP students attend conference

    NASA Technical Reports Server (NTRS)

    2009-01-01

    Last month, Madeline Brozen and Jason Jones of the DEVELOP Program at John C. Stennis Space Center joined members from the program's national office at Langley Research Center to attend the Southern Growth Policies Board annual conference in Biloxi. Pictured are (l to r): Karen Allsbrook, Jonathan Gleason, Gov. Haley Barbour, Madeline Brozen, Lindsay Rogers and Tracey Silcox.

  11. Constellation Program Press Conference

    NASA Image and Video Library

    2006-06-04

    Jeff Hanley, Constellation Program Manager, speaks during a press conference outlining specific center responsibilities associated with the Constellation Program for robotic and human Moon and Mars exploration, Monday, June 5, 2006, at NASA Headquarters in Washington. Photo Credit (NASA/Bill Ingalls)

  12. Constellation Program Press Conference

    NASA Image and Video Library

    2006-06-04

    Dean Acosta, NASA Deputy Assistant Administrator and Press Secretary, moderates a press conference with NASA Administrator Michael Griffin Scott Horowitz, NASA Associate Administrator for Exploration Systems and Jeff Hanley, Constellation Program Manager, outlining specific center responsibilities associated with the Constellation Program for robotic and human Moon and Mars exploration, Monday, June 5, 2006, at NASA Headquarters in Washington. Photo Credit (NASA/Bill Ingalls)

  13. Constellation Program Press Conference

    NASA Image and Video Library

    2006-06-04

    Scott Horowitz, NASA Associate Administrator for Exploration Systems, left, looks on as Jeff Hanley, Constellation Program Manager, speaks during a press conference outlining specific center responsibilities associated with the Constellation Program for robotic and human Moon and Mars exploration, Monday, June 5, 2006, at NASA Headquarters in Washington. Photo Credit (NASA/Bill Ingalls)

  14. Constellation Program Press Conference

    NASA Image and Video Library

    2006-06-04

    NASA Administrator Michael Griffin, left, looks on as Scott Horowitz, NASA Associate Administrator for Exploration Systems speaks during a press conference outlining specific center responsibilities associated with the Constellation Program for robotic and human Moon and Mars exploration, Monday, June 5, 2006, at NASA Headquarters in Washington. Photo Credit (NASA/Bill Ingalls)

  15. Constellation Program Press Conference

    NASA Image and Video Library

    2006-06-04

    Members of the media listen during a press conference with NASA Administrator Michael Griffin, Scott Horowitz, NASA Associate Administrator for Exploration Systems and Jeff Hanley, Constellation Program Manager, outlining specific center responsibilities associated with the Constellation Program for robotic and human Moon and Mars exploration, Monday, June 5, 2006, at NASA Headquarters in Washington. Photo Credit (NASA/Bill Ingalls)

  16. Constellation Program Press Conference

    NASA Image and Video Library

    2006-06-04

    NASA Administrator Michael Griffin, speaks during a press conference outlining specific center responsibilities associated with the Constellation Program for robotic and human Moon and Mars exploration, Monday, June 5, 2006, at NASA Headquarters in Washington. Photo Credit (NASA/Bill Ingalls)

  17. Constellation Program Press Conference

    NASA Image and Video Library

    2006-06-04

    Scott Horowitz, NASA Associate Administrator for Exploration Systems, left, and Jeff Hanley, Constellation Program Manager, are seen during a press conference outlining specific center responsibilities associated with the Constellation Program for robotic and human Moon and Mars exploration, Monday, June 5, 2006, at NASA Headquarters in Washington. Photo Credit (NASA/Bill Ingalls)

  18. Conference on Navajo Orthography.

    ERIC Educational Resources Information Center

    Ohannessian, Sirarpi; And Others

    This report on the Conference on Navajo Orthography, held in Albuquerque, New Mexico on May 2-3, 1969 constitutes a summary of the discussion and decisions of a meeting which was convened by the Center for Applied Linguistics under contract with the Bureau of Indian Affairs to agree on an orthography for the Navajo language. The immediate purpose…

  19. Conference Abstracts: AEDS '84.

    ERIC Educational Resources Information Center

    Baird, William E.

    1985-01-01

    The Association of Educational Data Systems (AEDS) conference included 102 presentations. Abstracts of seven of these presentations are provided. Topic areas considered include LOGO, teaching probability through a computer game, writing effective computer assisted instructional materials, computer literacy, research on instructional…

  20. Effective Parent Conferences

    ERIC Educational Resources Information Center

    Elmore, Michael

    2008-01-01

    Conferences with an upset parent, teacher, or student should be opportunities for schools to build relationships with the community and to foster a positive school culture. But in reality, they are often held because a problem has arisen and often end with stakeholders having a less-than-positive image of the school. Understanding the steps that…

  1. A Conference of Hope.

    ERIC Educational Resources Information Center

    American Printing House for the Blind, Louisville, KY. Dept. of Educational Research.

    Presented are the proceedings of the First Historic Helen Keller World Conference on Services to Deaf-Blind Youths and Adults, held in New York City in September, 1977 on the theme "The Deaf-Blind Person in the Community." Reports have the following titles and authors: "Definition, Demography, Causes and Prevention of Deaf-Blindness; Finding and…

  2. Google Moon Press Conference

    NASA Image and Video Library

    2009-07-19

    Alan Eustace, Senior VP of Engineering and Research, Google, Inc., speaks during a press conference, Monday, July 20, 2009, announcing the launch of Moon in Google Earth, an immersive 3D atlas of the Moon, accessible within Google Earth 5.0, Monday, July 20, 2009, at the Newseum in Washington. Photo Credit: (NASA/Bill Ingalls)

  3. DEVELOP students attend conference

    NASA Image and Video Library

    2009-06-08

    Last month, Madeline Brozen and Jason Jones of the DEVELOP Program at John C. Stennis Space Center joined members from the program's national office at Langley Research Center to attend the Southern Growth Policies Board annual conference in Biloxi. Pictured are (l to r): Karen Allsbrook, Jonathan Gleason, Gov. Haley Barbour, Madeline Brozen, Lindsay Rogers and Tracey Silcox.

  4. A Conference of Hope.

    ERIC Educational Resources Information Center

    American Printing House for the Blind, Louisville, KY. Dept. of Educational Research.

    Presented are the proceedings of the First Historic Helen Keller World Conference on Services to Deaf-Blind Youths and Adults, held in New York City in September, 1977 on the theme "The Deaf-Blind Person in the Community." Reports have the following titles and authors: "Definition, Demography, Causes and Prevention of Deaf-Blindness; Finding and…

  5. ALA Conference 2009: Chicago Hope

    ERIC Educational Resources Information Center

    Berry, John N., III

    2009-01-01

    There is joy among those who have the funds to go to Chicago for the American Library Association (ALA) annual conference, July 9-15. Every librarian knows there is nothing better than a Chicago gathering, with the city's wonderful haunts, museums, restaurants, and fine memories of past conferences. The conference program covers nearly every…

  6. Making Connections: Attending Professional Conferences

    ERIC Educational Resources Information Center

    Cherrstrom, Catherine A.

    2012-01-01

    Attending a professional conference is an effective way to explore and advance knowledge, skills, and careers. For graduate students, attending a conference is an effective way to explore academic fields and new professions. However, attending a professional conference requires precious resources--time and money--so the decision to attend, or not,…

  7. ALA Conference 2009: Chicago Hope

    ERIC Educational Resources Information Center

    Berry, John N., III

    2009-01-01

    There is joy among those who have the funds to go to Chicago for the American Library Association (ALA) annual conference, July 9-15. Every librarian knows there is nothing better than a Chicago gathering, with the city's wonderful haunts, museums, restaurants, and fine memories of past conferences. The conference program covers nearly every…

  8. Summary: A Very Timely Conference

    NASA Astrophysics Data System (ADS)

    Wyse, Rosemary F. G.

    2012-04-01

    The conference poster includes a very apt phrase that describes a primary motivation for this conference: Time discovers truth. This aphorism, attributed to Seneca, was certainly affirmed by the many exciting talks and discussions at this conference, in both formal and informal settings.

  9. Cancer metabolism: current perspectives and future directions

    PubMed Central

    Muñoz-Pinedo, C; El Mjiyad, N; Ricci, J-E

    2012-01-01

    Cellular metabolism influences life and death decisions. An emerging theme in cancer biology is that metabolic regulation is intricately linked to cancer progression. In part, this is due to the fact that proliferation is tightly regulated by availability of nutrients. Mitogenic signals promote nutrient uptake and synthesis of DNA, RNA, proteins and lipids. Therefore, it seems straight-forward that oncogenes, that often promote proliferation, also promote metabolic changes. In this review we summarize our current understanding of how ‘metabolic transformation' is linked to oncogenic transformation, and why inhibition of metabolism may prove a cancer′s ‘Achilles' heel'. On one hand, mutation of metabolic enzymes and metabolic stress sensors confers synthetic lethality with inhibitors of metabolism. On the other hand, hyperactivation of oncogenic pathways makes tumors more susceptible to metabolic inhibition. Conversely, an adequate nutrient supply and active metabolism regulates Bcl-2 family proteins and inhibits susceptibility to apoptosis. Here, we provide an overview of the metabolic pathways that represent anti-cancer targets and the cell death pathways engaged by metabolic inhibitors. Additionally, we will detail the similarities between metabolism of cancer cells and metabolism of proliferating cells. PMID:22237205

  10. Cancer metabolism: current perspectives and future directions.

    PubMed

    Muñoz-Pinedo, C; El Mjiyad, N; Ricci, J-E

    2012-01-12

    Cellular metabolism influences life and death decisions. An emerging theme in cancer biology is that metabolic regulation is intricately linked to cancer progression. In part, this is due to the fact that proliferation is tightly regulated by availability of nutrients. Mitogenic signals promote nutrient uptake and synthesis of DNA, RNA, proteins and lipids. Therefore, it seems straight-forward that oncogenes, that often promote proliferation, also promote metabolic changes. In this review we summarize our current understanding of how 'metabolic transformation' is linked to oncogenic transformation, and why inhibition of metabolism may prove a cancer's 'Achilles' heel'. On one hand, mutation of metabolic enzymes and metabolic stress sensors confers synthetic lethality with inhibitors of metabolism. On the other hand, hyperactivation of oncogenic pathways makes tumors more susceptible to metabolic inhibition. Conversely, an adequate nutrient supply and active metabolism regulates Bcl-2 family proteins and inhibits susceptibility to apoptosis. Here, we provide an overview of the metabolic pathways that represent anti-cancer targets and the cell death pathways engaged by metabolic inhibitors. Additionally, we will detail the similarities between metabolism of cancer cells and metabolism of proliferating cells.

  11. NIH Consensus Conference. Acupuncture.

    PubMed

    1998-11-04

    To provide clinicians, patients, and the general public with a responsible assessment of the use and effectiveness of acupuncture to treat a variety of conditions. A nonfederal, nonadvocate, 12-member panel representing the fields of acupuncture, pain, psychology, psychiatry, physical medicine and rehabilitation, drug abuse, family practice, internal medicine, health policy, epidemiology, statistics, physiology, biophysics, and the representatives of the public. In addition, 25 experts from these same fields presented data to the panel and a conference audience of 1200. Presentations and discussions were divided into 3 phases over 2 1/2 days: (1) presentations by investigators working in areas relevant to the consensus questions during a 2-day public session; (2) questions and statements from conference attendees during open discussion periods that were part of the public session; and (3) closed deliberations by the panel during the remainder of the second day and morning of the third. The conference was organized and supported by the Office of Alternative Medicine and the Office of Medical Applications of Research, National Institutes of Health, Bethesda, Md. The literature, produced from January 1970 to October 1997, was searched through MEDLINE, Allied and Alternative Medicine, EMBASE, and MANTIS, as well as through a hand search of 9 journals that were not indexed by the National Library of Medicine. An extensive bibliography of 2302 references was provided to the panel and the conference audience. Expert speakers prepared abstracts of their own conference presentations with relevant citations from the literature. Scientific evidence was given precedence over clinical anecdotal experience. The panel, answering predefined questions, developed their conclusions based on the scientific evidence presented in the open forum and scientific literature. The panel composed a draft statement, which was read in its entirety and circulated to the experts and the audience

  12. European Conference on Health Economics.

    PubMed

    Malmivaara, Antti

    2010-12-01

    The biennial European Conference on Health Economics was held in Finland this year, at the Finlandia Hall in the centre of Helsinki. The European conferences rotate among European countries and fall between the biennial world congresses organized by the International Health Economics Association (iHEA). A record attendance of approximately 800 delegates from 50 countries around the world were present at the Helsinki conference. The theme of the conference was 'Connecting Health and Economics'. All major topics of health economics were covered in the sessions. For the first time, social care economics was included in the agenda of the European Conference as a session of its own.

  13. Yeast Exocytic v-SNAREs Confer Endocytosis

    PubMed Central

    Gurunathan, Sangiliyandi; Chapman-Shimshoni, Daphne; Trajkovic, Selena; Gerst, Jeffrey E.

    2000-01-01

    In yeast, homologues of the synaptobrevin/VAMP family of v-SNAREs (Snc1 and Snc2) confer the docking and fusion of secretory vesicles at the cell surface. As no v-SNARE has been shown to confer endocytosis, we examined whether yeast lacking the SNC genes, or possessing a temperature-sensitive allele of SNC1 (SNC1ala43), are deficient in the endocytic uptake of components from the cell surface. We found that both SNC and temperature-shifted SNC1ala43 yeast are deficient in their ability to deliver the soluble dye FM4–64 to the vacuole. Under conditions in which vesicles accumulate, FM4–64 stained primarily the cytoplasm as well as fragmented vacuoles. In addition, α-factor–stimulated endocytosis of the α-factor receptor, Ste2, was fully blocked, as evidenced using a Ste2-green fluorescent protein fusion protein as well as metabolic labeling studies. This suggests a direct role for Snc v-SNAREs in the retrieval of membrane proteins from the cell surface. Moreover, this idea is supported by genetic and physical data that demonstrate functional interactions with t-SNAREs that confer endosomal transport (e.g., Tlg1,2). Notably, Snc1ala43 was found to be nonfunctional in cells lacking Tlg1 or Tlg2. Thus, we propose that synaptobrevin/VAMP family members are engaged in anterograde and retrograde protein sorting steps between the Golgi and the plasma membrane. PMID:11029060

  14. Applied and Environmental Microbiology Gordon Research Conference

    SciTech Connect

    Wall, Judy D.

    2003-11-19

    The main objective of the Gordon Research Conference on Applied and Environmental Microbiology was to present and discuss new, fundamental research findings on microorganisms, their activities in the environment, their ecosystem-level effects, and their environmental or commercial applications. To accomplish this goal, knowledge of microbial diversity, interactions and population dynamics was required. The genomic basis of microbial processes, the cycling of naturally occurring and hazardous substances, and methodologies to assess the functional relationships of microorganisms in their habitats were essential for understanding the ecological consequences of microbial activities and the formulation of generalizing principles. In the last decade, molecular technology has revealed that microbial diversity is far more extensive than the limited view obtained from culturing procedures. Great advances in environmental microbiology have resulted from the development and application of molecular approaches to ecology and molecular evolution. A further surprise resulting from the application of these new tools is the blurring of the distinction between pathogenic traits versus those considered non-pathogenic. This year's conference addressed the issues of biodiversity, its development, and the impact of stress on gene selection and expression. In addition microbial metabolic versatility with toxins such as heavy metals, antibiotics, and organic pollutants were discussed. The nine session topics were (1) biodiversity and the bacterial species, (2) mechanisms of biodiversification, (3) biofilms in health and environment, (4) a genomic view of microbial response to stress, (5) microbial use of toxic metals, (6) microbial mineral formation and dissolution, (7) power and limitations of antimicrobials, (8) biodegradation of organic pollutants, and (9) astrobiology. The Conference had an international profile: the Conference Vice-Chair, Dr. Gerard Muyzer, was from The Nether lands

  15. Energy Conferences and Symposia; (USA)

    SciTech Connect

    Osborne, J.H.; Simpson, W.F. Jr.

    1991-01-01

    Energy Conferences and Symposia, a monthly publication, was instituted to keep scientists, engineers, managers, and related energy professionals abreast of meetings sponsored by the Department of Energy (DOE) and by other technical associations. Announcements cover conference, symposia, workshops, congresses, and other formal meetings pertaining to DOE programmatic interests. Complete meeting information, including title, sponsor, and contact, is presented in the main section, which is arranged alphabetically by subject area. Within a subject, citations are sorted by beginning data of the meeting. New listings are indicated by a bullet after the conference number and DOE-sponsored conferences are indicated by a star. Two indexes are provided for cross referencing conference information. The Chronological Index lists conference titles by dates and gives the subject area where complete information they may be found. The Location Index is alphabetically sorted by the city where the conference will be held.

  16. Mississippi Climate & Hydrology Conference

    SciTech Connect

    Lawford, R.; Huang, J.

    2002-05-01

    The GEWEX Continental International Project (GCIP), which started in 1995 and completed in 2001, held its grand finale conference in New Orleans, LA in May 2002. Participants at this conference along with the scientists funded through the GCIP program are invited to contribute a paper to a special issue of Journal of Geophysical Research (JGR). This special JGR issue (called GCIP3) will serve as the final report on scientific research conducted by GCIP investigators. Papers are solicited on the following topical areas, but are not limited to, (1) water energy budget studies; (2) warm season precipitation; (3) predictability and prediction system; (4) coupled land-atmosphere models; (5) climate and water resources applications. The research areas cover observations, modeling, process studies and water resources applications.

  17. NSI conference support

    NASA Technical Reports Server (NTRS)

    Aaron, Susan

    1991-01-01

    One of the many services NSI provides as an extension of customer/user support is to attend major scientific conferences. The conference effort provides NASA/OSSA scientists with many benefits: (1) scientist get to see NSI in action; they utilize the network to read email, and have recently begun to demonstrate their scientific research to their colleagues; (2) scientist get an opportunity to meet and interact with NSI Staff, which gives scientists a chance to get status on their requirements, ask about network status, get acquainted with our procedures, and learn about services; and (3) scientists are exposed to networking in a larger sense; particularly by knowing about other NASA groups who provide valuable scientific resources over the Internet.

  18. Expedition 41 Press Conference

    NASA Image and Video Library

    2014-09-24

    Expedition 41 Soyuz Commander Alexander Samokutyaev of the Russian Federal Space Agency (Roscosmos) and Flight Engineer Elena Serova of Roscosmos hold up tiger toys that will be carried with them to the International Space Station to commemorate International Tiger Day at a press conference held at the Cosmonaut Hotel in Baikonur, Kazakhstan on Wednesday, Sept. 24, 2014. The mission is set to launch Sept. 26 from the Baikonur Cosmodrome. Photo Credit: (NASA/Aubrey Gemignani)

  19. Expedition 32 Press Conference

    NASA Image and Video Library

    2012-07-13

    Quarantined Expedition 32 JAXA (Japan Aerospace Exploration Agency) Flight Engineer Akihiko Hoshide answers reporters questions from behind glass during a prelaunch press conference held at the Cosmonaut Hotel on Friday, July 13, 2012 in Baikonur, Kazakhstan. The launch of the Soyuz spacecraft with Hoshide, Soyuz Commander Yuri Malenchenko, and NASA Flight Engineer Sunita Williams is scheduled for 8:40 a.m. local time on Sunday, July 15. Photo Credit (NASA/Carla Cioffi)

  20. Expedition 34 Press Conference

    NASA Image and Video Library

    2012-12-18

    Expedition 34/35 NASA Flight Engineer Tom Marshburn answers a reporter's question at a press conference held at the Cosmonaut Hotel, on Tuesday, Dec. 18, 2012, in Baikonur, Kazakhstan. Launch of the Soyuz rocket is scheduled for December 19 and will send Marshburn, Roman Romanenko of ROSCOSMOS and Chris Hadfield of the Canadian Space Agency on a five-month mission aboard the International Space Station. Photo Credit: (NASA/Carla Cioffi)

  1. Expedition 32 Press Conference

    NASA Image and Video Library

    2012-07-13

    Quarantined Expedition 32 JAXA (Japan Aerospace Exploration Agency) Flight Engineer Akihiko Hoshide, left, answers reporters questions from behind glass during a prelaunch press conference held at the Cosmonaut Hotel on Friday, July 13, 2012 in Baikonur, Kazakhstan. Seated next to him is Soyuz Commander Yuri Malenchenko. The launch of the Soyuz spacecraft with Hoshide, Malenchenko, and NASA Flight Engineer Sunita Williams is scheduled for 8:40 a.m. local time on Sunday, July 15. Photo Credit (NASA/Carla Cioffi)

  2. Expedition 34 Press Conference

    NASA Image and Video Library

    2012-12-18

    Expedition 34/35 Flight Engineer and Expedition 35 Commander Chris Hadfield of the Canadian Space Agency (CSA) answers a reporter's question at a press conference held at the Cosmonaut Hotel, on Tuesday, Dec. 18, 2012, in Baikonur, Kazakhstan. Launch of the Soyuz rocket is scheduled for December 19 and will send Hadfield, Tom Marshburn of NASA and Roman Romanenko of ROSCOSMOS on a five-month mission aboard the International Space Station. Photo Credit: (NASA/Carla Cioffi)

  3. Expedition 33 Press Conference

    NASA Image and Video Library

    2012-10-22

    Expedition 33 Soyuz Commander Oleg Novitskiy answers a reporters question during a press conference held at the Cosmonaut Hotel, on Monday, October 22, 2012, in Baikonur, Kazakhstan. Launch of the Soyuz rocket is scheduled for October 23 and will send Expedition 33/34 Flight Engineer Kevin Ford of NASA, Soyuz Commander Oleg Novitskiy and Flight Engineer Evgeny Tarelkin of ROSCOSMOS on a five-month mission aboard the International Space Station. Photo Credit: (NASA/Bill Ingalls)

  4. Expedition 32 Press Conference

    NASA Image and Video Library

    2012-07-13

    Quarantined Expedition 32 Soyuz Commander Yuri Malenchenko, right, answers reporters questions from behind glass during a prelaunch press conference held at the Cosmonaut Hotel on Friday, July 13, 2012 in Baikonur, Kazakhstan. Seated next to him is JAXA Flight Engineer Akihiko Hoshide. The launch of the Soyuz spacecraft with Malenchenko, NASA Flight Engineer Sunita Williams and Hoshide is scheduled for 8:40 a.m. local time on Sunday, July 15. Photo Credit (NASA/Carla Cioffi)

  5. Expedition 37 Press Conference

    NASA Image and Video Library

    2013-09-24

    Expedition 37 NASA Flight Engineer Michael Hopkins answers a reporter's question at a press conference held at the Cosmonaut Hotel, on Tuesday, Sept. 24, 2013, in Baikonur, Kazakhstan. Launch of the Soyuz rocket is scheduled for September 26 and will send Hopkins, Soyuz Commander Oleg Kotov and Russian Flight Engineer Sergei Ryazansky on a five and a half-month mission aboard the International Space Station. Photo Credit: (NASA/Carla Cioffi)

  6. Expedition 37 Press Conference

    NASA Image and Video Library

    2013-09-24

    Expedition 37 backup crewmember Alexander Skvortsov anwers a reporter’s question at a press conference held at the Cosmonaut Hotel, on Tuesday, Sept. 24, 2013, in Baikonur, Kazakhstan. Launch of the Soyuz rocket is scheduled for September 26 and will send Kotov, Hopkins and Ryazansky on a five and a half-month mission aboard the International Space Station. Photo Credit: (NASA/Carla Cioffi)

  7. Astrobiology Press Conference

    NASA Image and Video Library

    2010-12-02

    Steven Benner, a distinguished fellow at the Foundation for Applied Molecular Evolution, speaks during a press conference, Thursday, Dec. 2, 2010, at NASA Headquarters in Washington. NASA-funded astrobiology research has changed the fundamental knowledge about what comprises all known life on Earth. Researchers conducting tests in the harsh environment of Mono Lake in California have discovered the first known microorganism on Earth able to thrive and reproduce using the toxic chemical arsenic. Photo Credit: (NASA/Paul E. Alers)

  8. Astrobiology Press Conference

    NASA Image and Video Library

    2010-12-02

    Felisa Wolfe-Simon, a lead researcher and NASA astrobiology research fellow, speaks during a press conference, Thursday, Dec. 2, 2010, at NASA Headquarters in Washington. NASA-funded astrobiology research has changed the fundamental knowledge about what comprises all known life on Earth. Researchers conducting tests in the harsh environment of Mono Lake in California have discovered the first known microorganism on Earth able to thrive and reproduce using the toxic chemical arsenic. Photo Credit: (NASA/Paul E. Alers)

  9. Astrobiology Press Conference

    NASA Image and Video Library

    2010-12-02

    Felisa Wolfe-Simon, director, Astrobiology Program, NASA Headquarters, speaks during a press conference, Thursday, Dec. 2, 2010, at NASA Headquarters in Washington. NASA-funded astrobiology research has changed the fundamental knowledge about what comprises all known life on Earth. Researchers conducting tests in the harsh environment of Mono Lake in California have discovered the first known microorganism on Earth able to thrive and reproduce using the toxic chemical arsenic. Photo Credit: (NASA/Paul E. Alers)

  10. Astrobiology Press Conference

    NASA Image and Video Library

    2010-12-02

    Pamela Conrad, an astrobiologist from Goddard Space Flight Center, speaks during a press conference, Thursday, Dec. 2, 2010, at NASA Headquarters in Washington. NASA-funded astrobiology research has changed the fundamental knowledge about what comprises all known life on Earth. Researchers conducting tests in the harsh environment of Mono Lake in California have discovered the first known microorganism on Earth able to thrive and reproduce using the toxic chemical arsenic. Photo Credit: (NASA/Paul E. Alers)

  11. Military Energy Alternatives Conference

    DTIC Science & Technology

    2012-03-08

    Power Generation and Alternative Energy Branch US Army RDECOM CERDEC CP&ID Power Division Aberdeen Proving Ground, MD...RDER-CCA-PG PG A E - C R – 1 2– 0 1 M ili ta ry E ne rg y A lte rn at iv es C on fe re nc e Military Energy ...TITLE AND SUBTITLE Military Energy Alternatives Conference 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Jonathan

  12. Expedition 38 Press Conference

    NASA Image and Video Library

    2013-11-06

    Expedition 38 backup crew member Reid Wiseman of NASA is seen in quarantine, behind glass, during the final press conference held a day ahead of the launch of Expedition 38 prime crew members; Flight Engineer Koichi Wakata of the Japan Aerospace Exploration Agency, Soyuz Commander Mikhail Tyurin of Roscosmos, and, Flight Engineer Rick Mastracchio of NASA, to the International Space Station, Wednesday, Nov. 6, 2013 at the Cosmonaut Hotel in Baikonur, Kazakhstan. Photo Credit: (NASA/Bill Ingalls)

  13. Expedition 41 Press Conference

    NASA Image and Video Library

    2014-09-24

    NASA Expedition 41 backup crew member Flight Engineer Scott Kelly of NASA answers a question during a press conference Wednesday, Sept. 24, 2014 at the Cosmonaut Hotel in Baikonur, Kazakhstan. Expedition 41 Flight Engineer Barry Wilmore of NASA, Soyuz Commander Alexander Samokutyaev of the Russian Federal Space Agency (Roscosmos), and Flight Engineer Elena Serova of Roscosmos are set to launch Sept. 26 from the Baikonur Cosmodrome. Photo Credit: (NASA/Aubrey Gemignani)

  14. Expedition 38 Press Conference

    NASA Image and Video Library

    2013-11-06

    Expedition 38 Soyuz Commander Mikhail Tyurin of Roscosmos, right, talks as Flight Engineer Koichi Wakata of the Japan Aerospace Exploration Agency, listens, from quarantine behind glass, during the final press conference held a day ahead of their launch with fellow crew mate, Flight Engineer Rick Mastracchio of NASA, to the International Space Station, Wednesday, Nov. 6, 2013 at the Cosmonaut Hotel in Baikonur, Kazakhstan. Photo Credit: (NASA/Bill Ingalls)

  15. Expedition 38 Press Conference

    NASA Image and Video Library

    2013-11-06

    Expedition 38 Flight Engineer Koichi Wakata of the Japan Aerospace Exploration Agency is seen in quarantine, behind glass, during the final press conference held a day ahead of his launch with fellow crew mates, Expedition 38 Soyuz Commander Mikhail Tyurin of Roscosmos, and, Flight Engineer Rick Mastracchio of NASA, to the International Space Station, Wednesday, Nov. 6, 2013 at the Cosmonaut Hotel in Baikonur, Kazakhstan. Photo Credit: (NASA/Bill Ingalls)

  16. Expedition 41 Press Conference

    NASA Image and Video Library

    2014-09-24

    Expedition 41 Flight Engineer Barry Wilmore of NASA answers a question during a press conference on Wednesday, Sept. 24, 2014, at the Cosmonaut Hotel in Baikonur, Kazakhstan. Launch of the Soyuz rocket is scheduled for Sept. 26 and will carry Wilmore, Elena Serova of the Russian Federal Space Agency (Roscosmos), and Alexander Samokutyaev of Roscosmos into orbit to begin their five and a half month mission on the International Space Station. Photo Credit: (NASA/Aubrey Gemignani)

  17. Expedition 38 Press Conference

    NASA Image and Video Library

    2013-11-06

    Expedition 38 Soyuz Commander Mikhail Tyurin of Roscosmos is seen in quarantine behind glass during the final press conference held a day ahead of his launch with fellow crew mates, Flight Engineer Koichi Wakata of the Japan Aerospace Exploration Agency, and, Flight Engineer Rick Mastracchio of NASA, to the International Space Station, Wednesday, Nov. 6, 2013 at the Cosmonaut Hotel in Baikonur, Kazakhstan. Photo Credit: (NASA/Bill Ingalls)

  18. Expedition 38 Press Conference

    NASA Image and Video Library

    2013-11-06

    Expedition 38 backup crew member Alexander Gerst of the European Space Agency is seen in quarantine, behind glass, during the final press conference held a day ahead of the launch of Expedition 38 prime crew members; Flight Engineer Koichi Wakata of the Japan Aerospace Exploration Agency, Soyuz Commander Mikhail Tyurin of Roscosmos, and, Flight Engineer Rick Mastracchio of NASA, to the International Space Station, Wednesday, Nov. 6, 2013 at the Cosmonaut Hotel in Baikonur, Kazakhstan. Photo Credit: (NASA/Bill Ingalls)

  19. Kepler Press Conference

    NASA Image and Video Library

    2009-08-05

    William Bo-Ricki, Kepler principal investigator at NASA's Ames Research Center, speaks during a press conference, Thursday, Aug. 6, 2009, at NASA Headquarters in Washington about the scientific observations coming from the Kepler spacecraft that was launched this past March. Kepler is NASA's first mission that is capable of discovering earth-sized planets in the habitable zones of stars like our Sun. Photo Credit: (NASA/Paul E. Alers)

  20. Kepler Press Conference

    NASA Image and Video Library

    2009-08-05

    Jon Morse, NASA's Astrophysics Division Director, left, speaks during a press conference, Thursday, Aug. 6, 2009, at NASA Headquarters in Washington about the scientific observations coming from the Kepler spacecraft that was launched this past March asWilliam Bo-Ricki, Kepler principal investigator at NASA's Ames Research Center, looks on. Kepler is NASA's first mission that is capable of discovering earth-sized planets in the habitable zones of stars like our Sun. Photo Credit: (NASA/Paul E. Alers)

  1. Kepler Press Conference

    NASA Image and Video Library

    2009-08-05

    Sara Seager, Professor of Planetary Science at the Massachusetts Institute of Technology, speaks during a press conference, Thursday, Aug. 6, 2009, at NASA Headquarters in Washington about the scientific observations coming from the Kepler spacecraft that was launched this past March. Kepler is NASA's first mission that is capable of discovering earth-sized planets in the habitable zones of stars like our Sun. Photo Credit: (NASA/Paul E. Alers)

  2. Constellation Program Press Conference

    NASA Image and Video Library

    2006-06-04

    NASA Administrator Michael Griffin, seated left, Scott Horowitz, NASA Associate Administrator for Exploration Systems and Jeff Hanley, Constellation Program Manager, right, are seen during a press conference outlining specific center responsibilities associated with the Constellation Program for robotic and human moon and Mars exploration, Monday, June 5, 2006, at NASA Headquarters in Washington. Dean Acosta, NASA Deputy Assistant Administrator and Press Secretary, far left, moderates the program. Photo Credit (NASA/Bill Ingalls)

  3. SAARC Conference on Children.

    PubMed

    1992-01-01

    In September 1992, in Colombo, Sri Lanka, ministry representatives attended the 2nd South Asian Ministerial Conference on Children to discuss child survival and safe motherhood, maternal and child nutrition, basic education, safe water, sanitation, the environment, child rights, and sociopolitical strategy to reach goals and to reduce poverty. To achieve the 7 major goals and essential supportive goals for the region, each country must define tasks in manageable terms based on country-specific and community-specific needs and importance while at the same time countries should cooperate to strengthen prospects of achieving goals emerging as priorities. The Conference called for countries to reinforce their National Plans of Action with a regional perspective and to consider representative goals in primary education, diarrhea control, iodine deficiency disorders, reducing gender disparity, family size, child labor, drinking water, guinea worm disease, immunization, maternal mortality, and nutrition. The Conference emphasized that the strategy for reaching child-centered goals should be integrated with the total development strategy and be a holistic approach. For example, governments need to expand social safety programs for children and women because of structural adjustments in the economy. The resolution also called on governments to allow community-led local planning. A working group at the conference made recommendations for supporting/sectoral goals on water supply, sanitation, and environment. For example, it called for universal access to potable water and sanitary means of excreta disposal by 2000 and for adequate shelter and services to improve the living environment of children in South Asia. Some recommended strategies to achieve these goals were community participation; decentralization; promotion of self-reliance, cost-sharing, and sustainability; and special training for women. Other areas they addressed were home gardens for vegetables and fruits

  4. Expedition 41 Press Conference

    NASA Image and Video Library

    2014-09-24

    Expedition 41 prime crew members, Flight Engineer Barry Wilmore of NASA, left, Soyuz Commander Alexander Samokutyaev of the Russian Federal Space Agency (Roscosmos), center, and Flight Engineer Elena Serova of Roscosmos, right, pose for a photo at the conclusion of the press conference held at the Cosmonaut Hotel in Baikonur, Kazakhstan on Wednesday, Sept. 24, 2014. Their mission to the International Space Station is set to launch Sept. 26 from the Baikonur Cosmodrome. Photo Credit: (NASA/Aubrey Gemignani)

  5. Expedition 52 Press Conference

    NASA Image and Video Library

    2017-07-10

    Expedition 52 prime and backup crews: Paolo Nespoli of ESA, left, Randy Bresnik of NASA, Sergey Ryazanskiy of Roscosmos, Alexander Misurkin of Roscosmos, Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA) and, Mark Vande Hei of NASA pose for group photograph at the conclusion of their crew press conference at the Gagarin Cosmonaut Training Center (GCTC), Monday, July 10, 2017 in Star City, Russia. Photo Credit: (NASA/Bill Ingalls)

  6. Expedition 40 Press Conference

    NASA Image and Video Library

    2014-05-27

    Expedition 40 Flight Engineer Alexander Gerst of the European Space Agency, ESA, left, Soyuz Commander Maxim Suraev of the Russian Federal Space Agency, Roscosmos, center, and Flight Engineer Reid Wiseman of NASA, right, wave to those gathered at the conclusion of a press conference, Tuesday, May 27, 2014, at the Cosmonaut Hotel in Baikonur, Kazakhstan. The mission to the International Space Station is set to launch May 29 from the Baikonur Cosmodrome. Photo Credit: (NASA/Joel Kowsky)

  7. Expedition 42 Press Conference

    NASA Image and Video Library

    2014-11-22

    Expedition 42 Flight Engineer Terry Virts of NASA (left), Soyuz Commander Anton Shkaplerov of the Russian Federal Space Agency (Roscosmos) (center), and Flight Engineer Samantha Cristoforetti of the European Space Agency (right), pose for a photo at the conclusion of the press conference, Saturday, Nov. 22, 2014, at the Cosmonaut Hotel in Baikonur, Kazakhstan. The mission to the International Space Station is set to launch Nov. 24 from the Baikonur Cosmodrome. Photo Credit: (NASA/Aubrey Gemignani)

  8. Expedition 40 Press Conference

    NASA Image and Video Library

    2014-05-27

    Expedition 40 Flight Engineer Alexander Gerst of the European Space Agency, ESA, left, Soyuz Commander Maxim Suraev of the Russian Federal Space Agency, Roscosmos, center, and Flight Engineer Reid Wiseman of NASA, right, pose for a picture at the conclusion of a press conference, Tuesday, May 27, 2014, at the Cosmonaut Hotel in Baikonur, Kazakhstan. The mission to the International Space Station is set to launch May 29 from the Baikonur Cosmodrome. Photo Credit: (NASA/Joel Kowsky)

  9. Expedition 41 Press Conference

    NASA Image and Video Library

    2014-09-24

    Expedition 41 Flight Engineer Barry Wilmore of NASA, left, Soyuz Commander Alexander Samokutyaev of the Russian Federal Space Agency (Roscosmos), center, and Flight Engineer Elena Serova of Roscosmos, right, wave to the crowd at the conclusion of the press conference, Wednesday, Sept. 24, 2014, at the Cosmonaut Hotel in Baikonur, Kazakhstan. The mission to the International Space Station is set to launch Sept. 26 from the Baikonur Cosmodrome. Photo Credit: (NASA/Aubrey Gemignani)

  10. GLORY Mission Press Conference

    NASA Image and Video Library

    2011-01-20

    Joy Bretthauer, Glory Program Executive, NASA Headquarters, talks about the launch of the GLORY mission during a news conference at NASA Headquarters, Thursday, Jan. 20, 2011, in Washington. NASA's newest Earth-observing research mission is scheduled for launch form Vandenburg Air Force Base in California on Feb. 23. The mission will improve our understanding of how the sun and tiny atmosppheric particles called aerosols affect Earth's climate. Photo Credit: (NASA/Paul E. Alers)

  11. GLORY Mission Press Conference

    NASA Image and Video Library

    2011-01-20

    Michael Mischenko, from NASA's Goddard Institute for Space Studies, and a Glory project scientist, talks about the launch of the GLORY mission during a news conference at NASA Headquarters, Thursday, Jan. 20, 2011, in Washington. NASA's newest Earth-observing research mission is scheduled for launch form Vandenburg Air Force Base in California on Feb. 23. The mission will improve our understanding of how the sun and tiny atmosppheric particles called aerosols affect Earth's climate. Photo Credit: (NASA/Paul E. Alers)

  12. Kepler Press Conference

    NASA Image and Video Library

    2009-08-05

    Alan Boss, an astrophyscist at the Carnegie Institution at the Department of Terrestrial Magnetism speaks during a press conference, Thursday, Aug. 6, 2009, at NASA Headquarters in Washington about the scientific observations coming from the Kepler spacecraft that was launched this past March. Kepler is NASA's first mission that is capable of discovering earth-sized planets in the habitable zones of stars like our Sun. Photo Credit: (NASA/Paul E. Alers)

  13. 2004 Mutagenesis Gordon Conference

    SciTech Connect

    Dr. Sue Jinks-Robertson

    2005-09-16

    Mutations are genetic alterations that drive biological evolution and cause many, if not all, human diseases. Mutation originates via two distinct mechanisms: ''vertical'' variation is de novo change of one or few bases, whereas ''horizontal'' variation occurs by genetic recombination, which creates new mosaics of pre-existing sequences. The Mutagenesis Conference has traditionally focused on the generation of mutagenic intermediates during normal DNA synthesis or in response to environmental insults, as well as the diverse repair mechanisms that prevent the fixation of such intermediates as permanent mutations. While the 2004 Conference will continue to focus on the molecular mechanisms of mutagenesis, there will be increased emphasis on the biological consequences of mutations, both in terms of evolutionary processes and in terms of human disease. The meeting will open with two historical accounts of mutation research that recapitulate the intellectual framework of this field and thereby place the current research paradigms into perspective. The two introductory keynote lectures will be followed by sessions on: (1) mutagenic systems, (2) hypermutable sequences, (3) mechanisms of mutation, (4) mutation avoidance systems, (5) mutation in human hereditary and infectious diseases, (6) mutation rates in evolution and genotype-phenotype relationships, (7) ecology, mutagenesis and the modeling of evolution and (8) genetic diversity of the human population and models for human mutagenesis. The Conference will end with a synthesis of the meeting as the keynote closing lecture.

  14. SALT Science Conference 2015

    NASA Astrophysics Data System (ADS)

    Buckley, David; Schroeder, Anja

    2015-06-01

    The Southern African Large Telescope (SALT) has seen great changes in the last years following the beginning of full time science operations in 2011. The three first generation instruments, namely the SALTICAM imager, the Robert Stobie Spectrograph (RSS) and its multiple modes and finally in 2014, the new High Resolution Spectrograph (HRS), have commissioned it. The SALT community now eagerly anticipate the installation and commissioning of the near-infrared arm of RSS, likely to commence in 2016. The the third "Science with SALT" conference was held at the Stellenbosch Institute of Advanced Study from 1-5 June 2015. The goals of this conference were to: -Present and discuss recent results from SALT observations; -Anticipate scientific programs that will be carried out with new SALT instrumentation such as RSS-NIR; -Provide a scientific environment in which to foster inter-institutional and inter-facility collaborations between scientists at the different SALT partners; -Provide an opportunity for students and postdocs to become more engaged in SALT science and operations; -Encourage the scientific strategic planning that will be necessary to insure an important role for SALT in an era of large astronomical facilities in the southern hemisphere such as MeerKAT, the SKA, LSST, and ALMA; -Consider options for future instrumentation and technical development of SALT; and, -Present, discuss, and engage in the SALT Collateral Benefits program led by SAAO. Conference proceedings editors: David Buckley and Anja Schroeder

  15. CONFERENCE NOTE: Forthcoming Conference on Frequency Metrology

    NASA Astrophysics Data System (ADS)

    1981-04-01

    The Third Symposium on Frequency Standards and Metrology will be held 5 7 October 1981 at the Centre Paul Langevin, Aussois, Savoie, France. This Conference will follow the lines of its predecessors at Forêt Montmorency, Quebec, Canada in September 1971 and at Copper Mountain, Colorado, USA in July 1976. It is intended to serve as a discussion forum on recent progress and ideas relating to precision frequency standards, the associated metrology and the specific fields of applications. A tentative list of the topics to be covered is the following: Progress in the field of atomic/molecular frequency standards throughout the electromagnetic spectrum Current trends and discussion of the precision capabilities of new techniques (Ramsey fringes in optics, cooling of atoms and ions . . . ) System application (VLBI, navigation . . .) and scientific applications (relativity, geodesy . . .) of atomic/molecular frequency standards and needs in these fields Modern distant time and frequency comparisons Progress in frequency synthesis of microwave to visible frequencies, etc. Most of the talks will be by invitation. Time will be provided for discussion, as well as for presentation of selected late ideas and results. Those interested in the Symposium should communicate with: Dr C Audoin, Laboratoire de l'Horloge Atomique, Bât. 221, Université Paris-Sud, 91405 Orsay Cedex, France.

  16. PREFACE: Wake Conference 2015

    NASA Astrophysics Data System (ADS)

    Barney, Andrew; Nørkær Sørensen, Jens; Ivanell, Stefan

    2015-06-01

    The 44 papers in this volume constitute the proceedings of the 2015 Wake Conference, held in Visby on the island of Gotland in Sweden. It is the fourth time this conference has been held. The Wake Conference series started in Visby, where it was held in 2009 and 2011. In 2013 it took place in Copenhagen where it was combined with the International Conference on Offshore Wind Energy and Ocean Energy. In 2015 it is back where it started in Visby, where it takes place at Uppsala University Campus Gotland, June 9th-11th. The global yearly production of electrical energy by wind turbines has grown tremendously in the past decade and it now comprises more than 3% of the global electrical power consumption. Today the wind power industry has a global annual turnover of more than 50 billion USD and an annual average growth rate of more than 20%. State-of-the-art wind turbines have rotor diameters of up to 150 m and 8 MW installed capacity. These turbines are often placed in large wind farms that have a total production capacity corresponding to that of a nuclear power plant. In order to make a substantial impact on one of the most significant challenges of our time, global warming, the industry's growth has to continue for a decade or two yet. This in turn requires research into the physics of wind turbine wakes and wind farms. Modern wind turbines are today clustered in wind farms in which the turbines are fully or partially influenced by the wake of upstream turbines. As a consequence, the wake behind the wind turbines has a lower mean wind speed and an increased turbulence level, as compared to the undisturbed flow outside the farm. Hence, wake interaction results in decreased total production of power, caused by lower kinetic energy in the wind, and an increase in the turbulence intensity. Therefore, understanding the physical nature of the vortices and their dynamics in the wake of a turbine is important for the optimal design of a wind farm. This conference is aimed

  17. 2011 Archaea: Ecology, Metabolism, & Molecular Biology

    SciTech Connect

    Keneth Stedman

    2011-08-05

    Archaea, one of three major evolutionary lineages of life, are a fascinating and diverse group of microbes with deep roots overlapping those of eukaryotes. The focus of the 'Archaea: Ecology Metabolism & Molecular Biology' GRC conference expands on a number of emerging topics highlighting new paradigms in archaeal metabolism, genome function and systems biology; information processing; evolution and the tree of life; the ecology and diversity of archaea and their viruses. The strength of this conference lies in its ability to couple a field with a rich history in high quality research with new scientific findings in an atmosphere of stimulating exchange. This conference remains an excellent opportunity for younger scientists to interact with world experts in this field.

  18. 2009 Archaea: Ecology, Metabolism & Molecular Biology GRC

    SciTech Connect

    Furlow, Julie Maupin-

    2009-07-26

    Archaea, one of three major evolutionary lineages of life, are a fascinating and diverse group of microbes with deep roots overlapping those of eukaryotes. The focus of the 'Archaea: Ecology Metabolism & Molecular Biology' GRC conference expands on a number of emerging topics highlighting new paradigms in archaeal metabolism, genome function and systems biology; information processing; evolution and the tree of life; the ecology and diversity of archaea and their viruses; and industrial applications. The strength of this conference lies in its ability to couple a field with a rich history in high quality research with new scientific findings in an atmosphere of stimulating exchange. This conference remains an excellent opportunity for younger scientists to interact with world experts in this field.

  19. Automated Author Aiding System Conference

    DTIC Science & Technology

    1985-07-01

    0V) 0 Technical Report 684 r-Vass A Automated Author Aiding System Conference: Final Report edited by Nancy K. Atwood University of California at...AUTHOR AIDING SYSTEM CONFERENCE: Final Report FINAL REPORT June 84 through June 85 4. PERFORMING ORG. REPORT NUMBER 7. AUTHOM(I4~dited by Nancy K...Dots Entered) Technical Report 684 Automated Author Aiding System Conference: Final Report edited by Nancy K. Atwood University of California at Los

  20. Uptake, translocation, and metabolism of oxabetrinil and CGA-133205 in grain sorghum (Sorghum bicolor) and their influence on metolachlor metabolism

    SciTech Connect

    Yenne, S.P.; Hatzios, K.K.; Meredith, S.A. )

    1990-10-01

    The uptake, translocation, and metabolism of the oxime ether safeners oxabetrinil and CGA-133205 in grain sorghum (Sorghum bicolor (L.) Moench, var. Funk G-522-DR) were investigated. Following application of ({sup 14}C)oxabetrinil and ({sup 14}C)CGA-133205 to imbibed seeds, it appears that the safeners are conferring protection to grain sorghum by increasing the rate of metolachlor metabolism.

  1. Rural Energy Conference Project

    SciTech Connect

    Dennis Witmer; Shannon Watson

    2008-12-31

    Alaska remains, even at the beginning of the 21st century, a place with many widely scattered, small, remote communities, well beyond the end of both the road system and the power grid. These communities have the highest energy costs of any place in the United States, despite the best efforts of the utilities that service them. This is due to the widespread dependence on diesel electric generators, which require small capital investments, but recent increases in crude oil prices have resulted in dramatic increases in the cost of power. In the enabling legislation for the Arctic Energy Office in 2001, specific inclusion was made for the study of ways of reducing the cost of electrical power in these remote communities. As part of this mandate, the University of Alaska has, in conjunction with the US Department of Energy, the Denali Commission and the Alaska Energy Authority, organized a series of rural energy conferences, held approximately every 18 months. The goal of these meeting was to bring together rural utility operators, rural community leaders, government agency representatives, equipment suppliers, and researchers from universities and national laboratories to discuss the current state of the art in rural power generation, to discuss current projects, including successes as well as near successes. Many of the conference presenters were from industry and not accustomed to writing technical papers, so the typical method of organizing a conference by requesting abstracts and publishing proceedings was not considered viable. Instead, the organizing committee solicited presentations from appropriate individuals, and requested that (if they were comfortable with computers) prepare Power point presentations that were collected and posted on the web. This has become a repository of many presentations, and may be the best single source of information about current projects in the state of Alaska.

  2. Control Center Technology Conference Proceedings

    NASA Technical Reports Server (NTRS)

    1991-01-01

    Conference papers and presentations are compiled and cover evolving architectures and technologies applicable to flight control centers. Advances by NASA Centers and the aerospace industry are presented.

  3. SVC 2003 Technical Conference Summary

    SciTech Connect

    Martin, Peter M.

    2003-07-01

    The 46th Annual Technical Conference of the Society of Vacuum Coaters was held in San Francisco May 2-8. All the world events apparently did not affect the attendance or the spirit of the attendees. The Conference was a huge success and very well attended. Many feel that it was the best Techcon yet. This year's Conference really raised the bar for the 47th Annual Technical Conference in Dallas next year. Congratulations go out to the program committee, board of directors, education committee, scholarship committee and Management Plus for a job well done. Excellent accommodations were provided by the San Francisco Marriott.

  4. Expedition 18 Press Conference

    NASA Image and Video Library

    2008-10-10

    Expedition 18 Commander Michael Fincke answers reporters' questions during a press conference held at the Cosmonaut Hotel, Saturday, Oct. 11, 2008, in Baikonur, Kazakhstan. Fincke will launch on the Soyuz TMA-13 spacecraft along with Expedition 18 Flight Engineer Yuri V. Lonchakov and American spaceflight participant Richard Garriott on Oct. 12 and dock with the International Space Station on Oct. 14. Fincke and Lonchakov will spend six months on the station, while Garriott will return to Earth Oct. 24 with two of the Expedition 17 crew members currently on the International Space Station. Photo Credit: (NASA/Bill Ingalls)

  5. Expedition 18 Press Conference

    NASA Image and Video Library

    2008-10-10

    American spaceflight participant Richard Garriott, left, and Expedition 18 Commander Michael Fincke answer reporters' questions during a press conference held at the Cosmonaut Hotel, Saturday, Oct. 11, 2008, in Baikonur, Kazakhstan. Garriott and Fincke will launch on the Soyuz TMA-13 spacecraft along with Expedition 18 Flight Engineer Yuri V. Lonchakov on Oct. 12 and dock with the International Space Station on Oct. 14. Fincke and Lonchakov will spend six months on the station, while Garriott will return to Earth Oct. 24 with two of the Expedition 17 crew members currently on the International Space Station. Photo Credit: (NASA/Bill Ingalls)

  6. Expedition 18 Press Conference

    NASA Image and Video Library

    2008-10-10

    Expedition 18 Flight Engineer Yuri V. Lonchakov, right, Expedition 18 Commander Michael Fincke and American spaceflight participant Richard Garriott, left, pose for photographs after a press conference held at the Cosmonaut Hotel, Saturday, Oct. 11, 2008, in Baikonur, Kazakhstan. The Expedition 18 crew will launch on the Soyuz TMA-13 spacecraft on Oct. 12 and dock with the International Space Station on Oct. 14. Fincke and Lonchakov will spend six months on the station, while Garriott will return to Earth Oct. 24 with two of the Expedition 17 crew members currently on the International Space Station. Photo Credit: (NASA/Bill Ingalls)

  7. Expedition 18 Press Conference

    NASA Image and Video Library

    2008-10-10

    The quarantined crew, from left, American spaceflight participant Richard Garriott, Expedition 18 Commander Michael Fincke, Flight Engineer Yuri V. Lonchakov, back up Expedition 18 Commander Gennady Padalka, Flight Engineer Mike Barratt and spaceflight participant Nik Halik answer reporters questions during a press conference at the Cosmonaut Hotel, Saturday, Oct. 11, 2008, in Baikonur, Kazakhstan. Fincke, Lonchakov and Garriott are scheduled to launch Oct. 12 and dock with the International Space Station on Oct. 14. Fincke and Lonchakov will spend six months on the station, while Garriott will return to Earth Oct. 24 with two of the Expedition 17 crew members currently on the International Space Station. Photo Credit: (NASA/Bill Ingalls)

  8. Expedition 18 Press Conference

    NASA Image and Video Library

    2008-10-10

    Expedition 18 Commander Michael Fincke, left, and Flight Engineer Yuri V. Lonchakov answer reporters' questions during a press conference held at the Cosmonaut Hotel, Saturday, Oct. 11, 2008, in Baikonur, Kazakhstan. Fincke and Lonchakov will launch on the Soyuz TMA-13 spacecraft along with American spaceflight participant Richard Garriott on Oct. 12 and dock with the International Space Station on Oct. 14. Fincke and Lonchakov will spend six months on the station, while Garriott will return to Earth Oct. 24 with two of the Expedition 17 crew members currently on the International Space Station. Photo Credit: (NASA/Bill Ingalls)

  9. Expedition 18 Press Conference

    NASA Image and Video Library

    2008-10-10

    American spaceflight participant Richard Garriott answers reporters' questions during a press conference held at the Cosmonaut Hotel, Saturday, Oct. 11, 2008, in Baikonur, Kazakhstan. Garriott will launch on the Soyuz TMA-13 spacecraft along with Expedition 18 Commander Michael Fincke and Flight Engineer Yuri V. Lonchakov on Oct. 12 and dock with the International Space Station on Oct. 14. Fincke and Lonchakov will spend six months on the station, while Garriott will return to Earth Oct. 24 with two of the Expedition 17 crew members currently on the International Space Station. Photo Credit: (NASA/Bill Ingalls)

  10. Expedition 18 Press Conference

    NASA Image and Video Library

    2008-10-10

    Expedition 18 Flight Engineer Yuri V. Lonchakov answers reporters' questions during a press conference held at the Cosmonaut Hotel, Saturday, Oct. 11, 2008, in Baikonur, Kazakhstan. Lonchakov will launch on the Soyuz TMA-13 spacecraft along with Expedition 18 Commander Michael Fincke and American spaceflight participant Richard Garriott on Oct. 12 and dock with the International Space Station on Oct. 14. Fincke and Lonchakov will spend six months on the station, while Garriott will return to Earth Oct. 24 with two of the Expedition 17 crew members currently on the International Space Station. Photo Credit: (NASA/Bill Ingalls)

  11. Aerospace Environmental Technology Conference

    NASA Technical Reports Server (NTRS)

    Whitaker, A. F. (Editor)

    1995-01-01

    The mandated elimination of CFC's, Halons, TCA, and other ozone depleting chemicals and specific hazardous materials has required changes and new developments in aerospace materials and processes. The aerospace industry has been involved for several years in providing product substitutions, redesigning entire production processes, and developing new materials that minimize or eliminate damage to the environment. These activities emphasize replacement cleaning solvents and their application verifications, compliant coatings including corrosion protection systems, and removal techniques, chemical propulsion effects on the environment, and the initiation of modifications to relevant processing and manufacturing specifications and standards. The Executive Summary of this Conference is published as NASA CP-3297.

  12. Networks Technology Conference

    NASA Technical Reports Server (NTRS)

    Tasaki, Keiji K. (Editor)

    1993-01-01

    The papers included in these proceedings represent the most interesting and current topics being pursued by personnel at GSFC's Networks Division and supporting contractors involved in Space, Ground, and Deep Space Network (DSN) technical work. Although 29 papers are represented in the proceedings, only 12 were presented at the conference because of space and time limitations. The proceedings are organized according to five principal technical areas of interest to the Networks Division: Project Management; Network Operations; Network Control, Scheduling, and Monitoring; Modeling and Simulation; and Telecommunications Engineering.

  13. Expedition 43 Press Conference

    NASA Image and Video Library

    2015-03-26

    Expedition 43 Russian cosmonaut Gennady Padalka of the Russian Federal Space Agency (Roscosmos) listens to a reporter’s question as he and, Russian cosmonaut Mikhail Kornienko of Roscosmos, and NASA Astronaut Scott Kelly participate in a crew press conference, Thursday, March 26, 2015, at the Cosmonaut Hotel in Baikonur, Kazakhstan. Kelly, Kornienko, and Padalka launched to the International Space Station in the Soyuz TMA-16M spacecraft from the Baikonur Cosmodrome in Kazakhstan March 28, Kazakh time (March 27 Eastern time.) As the one-year crew, Kelly and Kornienko will return to Earth on Soyuz TMA-18M in March 2016. Photo Credit (NASA/Bill Ingalls)

  14. Expedition 43 Press Conference

    NASA Image and Video Library

    2015-03-26

    Expedition 43 Russian cosmonaut Mikhail Kornienko of the Russian Federal Space Agency (Roscosmos) answers reporter’s questions as he and, Russian cosmonaut Gennady Padalka of Roscosmos, and NASA Astronaut Scott Kelly participate in a crew press conference, Thursday, March 26, 2015, at the Cosmonaut Hotel in Baikonur, Kazakhstan. Kelly, Kornienko, and Padalka launched to the International Space Station in the Soyuz TMA-16M spacecraft from the Baikonur Cosmodrome in Kazakhstan March 28, Kazakh time (March 27 Eastern time.) As the one-year crew, Kelly and Kornienko will return to Earth on Soyuz TMA-18M in March 2016. Photo Credit (NASA/Bill Ingalls)

  15. Expedition 40 Press Conference

    NASA Image and Video Library

    2014-05-27

    Expedition 40 Soyuz Commander Maxim Suraev of the Russian Federal Space Agency, Roscosmos, second left, reacts as he is introduced during a press conference, Tuesday, May 27, 2014, at the Cosmonaut Hotel in Baikonur, Kazakhstan. Expedition 40 Soyuz Commander Maxim Suraev of the Russian Federal Space Agency, Roscosmos, Flight Engineer Alexander Gerst of the European Space Agency, ESA, and Flight Engineer Reid Wiseman of NASA will launch aboard their Soyuz TMA-13M spacecraft on their mission to the International Space Station in the early hours of May 29. Photo Credit: (NASA/Joel Kowsky)

  16. Astrobiology Press Conference

    NASA Image and Video Library

    2010-12-02

    Steven Benner, a distinguished fellow at the Foundation for Applied Molecular Evolution, right, speaks during a press conference as Mary Voytek, director of the Astrobiology Program at NASA looks on, Thursday, Dec. 2, 2010, at NASA Headquarters in Washington. NASA-funded astrobiology research has changed the fundamental knowledge about what comprises all known life on Earth. Researchers conducting tests in the harsh environment of Mono Lake in California have discovered the first known microorganism on Earth able to thrive and reproduce using the toxic chemical arsenic. Photo Credit: (NASA/Paul E. Alers)

  17. Astrobiology Press Conference

    NASA Image and Video Library

    2010-12-02

    Felisa Wolfe-Simon, a lead researcher and NASA astrobiology research fellow, speaks during a press conference, as Mary Voytek, Steven Benner and Pamela Conrad look on, Thursday, Dec. 2, 2010, at NASA Headquarters in Washington. NASA-funded astrobiology research has changed the fundamental knowledge about what comprises all known life on Earth. Researchers conducting tests in the harsh environment of Mono Lake in California have discovered the first known microorganism on Earth able to thrive and reproduce using the toxic chemical arsenic. Photo Credit: (NASA/Paul E. Alers)

  18. Kepler Press Conference

    NASA Image and Video Library

    2009-08-05

    William Bo-Ricki, Kepler principal investigator at NASA's Ames Research Center, second from left, speaks during a press conference, Thursday, Aug. 6, 2009, at NASA Headquarters in Washington about the scientific observations coming from the Kepler spacecraft that was launched this past March as Jon Morse, NASA's Astrophysics Division Director, left, looks on. Kepler is NASA's first mission that is capable of discovering earth-sized planets in the habitable zones of stars like our Sun. Photo Credit: (NASA/Paul E. Alers)

  19. GLORY Mission Press Conference

    NASA Image and Video Library

    2011-01-20

    Greg Kopp, from the University of Colorado's Laboratory for Atmospheric and Space Physics in Boulder, Colo., talks about the launch of the GLORY mission during a news conference at NASA Headquarters, Thursday, Jan. 20, 2011, in Washington. NASA's newest Earth-observing research mission is scheduled for launch form Vandenburg Air Force Base in California on Feb. 23. The mission will improve our understanding of how the sun and tiny atmosppheric particles called aerosols affect Earth's climate. Photo Credit: (NASA/Paul E. Alers)

  20. Kepler Press Conference

    NASA Image and Video Library

    2009-08-05

    William Bo-Ricki, Kepler principal investigator at NASA's Ames Research Center, second from left, speaks during a press conference, Thursday, Aug. 6, 2009, at NASA Headquarters in Washington about the scientific observations coming from the Kepler spacecraft that was launched this past March. Others seated include Jon Morse, NASA's Astrophysics Director, Sara Seager, Professor of Planetary Science and Physics at MIT, and Alan Boss, an Astrophysicist at the Carnegie Institution at the Department of Terrestrial Magnetism in Washington, right. Kepler is NASA's first mission that is capable of discovering earth-sized planets in the habitable zones of stars like our Sun. Photo Credit: (NASA/Paul E. Alers)

  1. Expedition 40 Press Conference

    NASA Image and Video Library

    2014-05-27

    Expedition 40 prime crew members Flight Engineer Alexander Gerst of the European Space Agency, ESA, far left, Soyuz Commander Maxim Suraev of the Russian Federal Space Agency, Roscosmos, second left, and Flight Engineer Reid Wiseman of NASA, center, pose for a picture with Expedition 40 backup crew members Flight Engineer Terry Virts of NASA, third right, Soyuz Commander Anton Shkaplerov of Roscosmos, and Flight Engineer Samantha Cristoforetti of ESA at the conclusion a press conference, Tuesday, May 27, 2014, at the Cosmonaut Hotel in Baikonur, Kazakhstan. The mission to the International Space Station is set to launch May 29 from the Baikonur Cosmodrome. Photo Credit: (NASA/Joel Kowsky)

  2. Expedition 42 Press Conference

    NASA Image and Video Library

    2014-11-22

    Family visits with Expedition 42 Soyuz Commander Anton Shkaplerov of the Russian Federal Space Agency (Roscosmos) through glass at the conclusion of the press conference, Saturday, Nov. 22, 2014, at the Cosmonaut Hotel in Baikonur, Kazakhstan. Launch of the Soyuz rocket is scheduled for Nov. 24 and will carry Shkaplerov, Flight Engineer Terry Virts of NASA , and Flight Engineer Samantha Cristoforetti of the European Space Agency into orbit to begin their five and a half month mission on the International Space Station. Photo Credit: (NASA/Aubrey Gemignani)

  3. Expedition 42 Press Conference

    NASA Image and Video Library

    2014-11-22

    Flight Engineer Samantha Cristoforetti of the European Space Agency (ESA) speaks with friends and family through glass at the conclusion of the press conference, Saturday, Nov. 22, 2014, at the Cosmonaut Hotel in Baikonur, Kazakhstan. Launch of the Soyuz rocket is scheduled for Nov. 24 and will carry Cristoforetti, Flight Engineer Terry Virts of NASA , and Soyuz Commander Anton Shkaplerov of the Russian Federal Space Agency (Roscosmos) into orbit to begin their five and a half month mission on the International Space Station. Photo Credit: (NASA/Aubrey Gemignani)

  4. Expedition 41 Press Conference

    NASA Image and Video Library

    2014-09-24

    Expedition 41 prime crew members, Flight Engineer Barry Wilmore of NASA, right, Soyuz Commander Alexander Samokutyaev of the Russian Federal Space Agency (Roscosmos), center, and Flight Engineer Elena Serova of Roscosmos, left, pose for a photo with items they will take with them to the International Space Station at the conclusion of the press conference held at the Cosmonaut Hotel in Baikonur, Kazakhstan on Wednesday, Sept. 24, 2014. The mission is set to launch Sept. 26 from the Baikonur Cosmodrome. Photo Credit: (NASA/Aubrey Gemignani)

  5. Expedition 40 Press Conference

    NASA Image and Video Library

    2014-05-27

    A reflection of the audience can been seen in the quarantine glass as Expedition 40 Flight Engineer Alexander Gerst of the European Space Agency, ESA, left, Soyuz Commander Maxim Suraev of the Russian Federal Space Agency, Roscosmos, center, and Flight Engineer Reid Wiseman of NASA, right, pose for a group picture at the conclusion of a press conference, Tuesday, May 27, 2014, at the Cosmonaut Hotel in Baikonur, Kazakhstan. The mission to the International Space Station is set to launch May 29 from the Baikonur Cosmodrome. Photo Credit: (NASA/Joel Kowsky)

  6. LEAP 1992: Conference summary

    SciTech Connect

    Dover, C.B.

    1992-12-01

    We present a summary of the many new results in antiproton ([bar p]) physics presented at the LEAP '92 conference, in the areas of meson spectroscopy, [bar N]N scattering, annihilation and spin observables, strangeness and charm production, [bar N] annihilation in nuclei, atomic physics with very low energy [bar p]'s, the exploration of fundamental symmetries and interactions with [bar p] (CP, T, CPT, gravitation), and the prospects for new [bar p] facilities at ultralow energies or energies above the LEAR regime ([ge] 2 GeV/c).

  7. LEAP 1992: Conference summary

    SciTech Connect

    Dover, C.B.

    1992-12-01

    We present a summary of the many new results in antiproton ({bar p}) physics presented at the LEAP `92 conference, in the areas of meson spectroscopy, {bar N}N scattering, annihilation and spin observables, strangeness and charm production, {bar N} annihilation in nuclei, atomic physics with very low energy {bar p}`s, the exploration of fundamental symmetries and interactions with {bar p} (CP, T, CPT, gravitation), and the prospects for new {bar p} facilities at ultralow energies or energies above the LEAR regime ({ge} 2 GeV/c).

  8. Kepler Press Conference

    NASA Image and Video Library

    2009-08-05

    William Bo-Ricki, Kepler principal investigator at NASA's Ames Research Center, second from left, is joined by Jon Morse, left, Sara Seager, and Alan Boss while speaking at a press conference, Thursday, Aug. 6, 2009, at NASA Headquarters in Washington about the scientific observations coming from the Kepler spacecraft that was launched this past March. Kepler is NASA's first mission that is capable of discovering earth-sized planets in the habitable zones of stars like our Sun. Photo Credit: (NASA/Paul E. Alers)

  9. 5 CFR 185.120 - Prehearing conferences.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Prehearing conferences. 185.120 Section... FRAUD CIVIL REMEDIES § 185.120 Prehearing conferences. (a) The ALJ may schedule prehearing conferences... conference at a reasonable time in advance of the hearing. (c) The ALJ may use prehearing conferences...

  10. 7 CFR 1753.10 - Preconstruction conference.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Preconstruction conference. 1753.10 Section 1753.10... conference. The borrower shall conduct a conference, attended by the borrower, contractor, and resident... participant with a copy of the conference results. The GFR shall be invited to attend this conference....

  11. 10 CFR 820.22 - Informal conference.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Informal conference. 820.22 Section 820.22 Energy... conference. The Director may convene an informal conference to discuss any situation that might be a... information. The Director may compel a person to attend the conference. This conference will not normally...

  12. 34 CFR 668.87 - Prehearing conference.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Prehearing conference. 668.87 Section 668.87 Education... Proceedings § 668.87 Prehearing conference. (a) A hearing official may convene a prehearing conference if he or she thinks that the conference would be useful, or if the conference is requested by— (1)...

  13. 29 CFR 2570.40 - Conferences.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Conferences. 2570.40 Section 2570.40 Labor Regulations... Transaction Exemption Applications § 2570.40 Conferences. (a) Any conference between the Department and an... conference will be held at the applicant's request. (b) An applicant is entitled to only one conference...

  14. National Conference[s] on Career Education: Final Report.

    ERIC Educational Resources Information Center

    Clark, Joseph F.; And Others

    The report describes a series of conferences whose objective was to orient selected educational leaders to the implications of preparing educational personnel with a career education perspective. The first 32 pages of the report discuss project objectives and procedures, and detail participant profiles, pre- and post-conference career education…

  15. History of NAMES Conferences

    NASA Astrophysics Data System (ADS)

    Filippov, Lev

    2013-03-01

    -Russian International Centre was demonstrated. By the high standards of the reports presented, as well as by its overall organization, the second Seminar met the standards of an international conference. Reviews of state-of-the-art developments in materials science were given by leading scientists from Moscow and from the Lorraine region. The three days of the seminar were structured into four main themes: Functional Materials Coatings, Films and Surface Engineering Nanomaterials and Nanotechnologies The Environment and three Round Table discussions: Defining practical means of carrying out Franco-Russian collaborations in technology transfer and innovation Materials science ARCUS: Lorraine-Russian collaboration in materials science and the environment 32 oral and 25 poster presentations within four sections were given by a total of 110 participants. NAMES 2007, the 3rd Franco-Russian Seminar on New Achievements in Materials and Environmental Sciences, took place in Metz, France on 7-9 November 2007. The conference highlights fundamentals and development of the five main themes connected to the Lorraine-Russia ARCUS project with possible extension to other topics. The five main subjects included in the ARCUS project are: Bulk-surface-interface material sciences Nanomaterials and nanotechnologies Environment and natural resources Plasma physics—ITER project Vibrational dynamics The first, second and third NAMES conferences were financially supported by the following organizations: Ambassade de France à Moscou Communauté Urbaine du Grand Nancy Région Lorraine Conseil Général de Meurthe et Moselle Institut National Polytechnique de Lorraine Université de Metz Université Henry Poincaré CNRS ANVAR Federal Agency on Science and Innovations of the Ministry of Education and Science of the Russian Federation Moscow Committee on Science and Technologies Moscow Institute of Steel and Alloys (Technological University) The 4th conference is supported by the Ministry of Foreign Affairs of

  16. (Tribology conferences and forums)

    SciTech Connect

    Yust, C.S.

    1990-11-30

    The principal meeting attended during this trip was the Japan International Tribology Conference Nagoya 1990. The conference encompassed a wide range of topics, including the tribology of ceramics, the tribology in high-performance automobiles, and many aspects of lubrication technology. Associated forums were also held on the tribology of advanced ceramics, on solid lubrication, and on automotive lubricants. Presentations made during the latter forum discussed anticipated trends in engine development and anticipated improvements in lubricants required for the next generation of engines. In addition to meetings, site visits were made to five industrial organizations to discuss ceramic tribology. Nippon Steel Corporation and Toshiba Corporation are both very active in the ceramic area, Nippon Steel from their interest in research on new materials and Toshiba from both an interest in new materials and in support of their work in electronic devices. Two engine manufacturers were also visited, Toyota Motor Corporation, and Nissan Motor Co., Ltd. These companies were somewhat reserved in their discussion of progress in the utilization of ceramics in automobile engines.

  17. Metabolic myopathies

    NASA Technical Reports Server (NTRS)

    Martin, A.; Haller, R. G.; Barohn, R.; Blomqvist, C. G. (Principal Investigator)

    1994-01-01

    Metabolic myopathies are disorders of muscle energy production that result in skeletal muscle dysfunction. Cardiac and systemic metabolic dysfunction may coexist. Symptoms are often intermittent and provoked by exercise or changes in supply of lipid and carbohydrate fuels. Specific disorders of lipid and carbohydrate metabolism in muscle are reviewed. Evaluation often requires provocative exercise testing. These tests may include ischemic forearm exercise, aerobic cycle exercise, and 31P magnetic resonance spectroscopy with exercise.

  18. Metabolic myopathies

    NASA Technical Reports Server (NTRS)

    Martin, A.; Haller, R. G.; Barohn, R.; Blomqvist, C. G. (Principal Investigator)

    1994-01-01

    Metabolic myopathies are disorders of muscle energy production that result in skeletal muscle dysfunction. Cardiac and systemic metabolic dysfunction may coexist. Symptoms are often intermittent and provoked by exercise or changes in supply of lipid and carbohydrate fuels. Specific disorders of lipid and carbohydrate metabolism in muscle are reviewed. Evaluation often requires provocative exercise testing. These tests may include ischemic forearm exercise, aerobic cycle exercise, and 31P magnetic resonance spectroscopy with exercise.

  19. Metabolic myopathies.

    PubMed

    Martin, A; Haller, R G; Barohn, R

    1994-11-01

    Metabolic myopathies are disorders of muscle energy production that result in skeletal muscle dysfunction. Cardiac and systemic metabolic dysfunction may coexist. Symptoms are often intermittent and provoked by exercise or changes in supply of lipid and carbohydrate fuels. Specific disorders of lipid and carbohydrate metabolism in muscle are reviewed. Evaluation often requires provocative exercise testing. These tests may include ischemic forearm exercise, aerobic cycle exercise, and 31P magnetic resonance spectroscopy with exercise.

  20. 2008 Gordon Research Conference on Catalysis [Conference summary report

    SciTech Connect

    Soled, Stuart L.; Gray, Nancy Ryan

    2009-01-01

    The GRC on Catalysis is one of the most prestigious catalysis conferences as it brings together leading researchers from around the world to discuss their latest, most exciting work in catalysis. The 2008 conference will continue this tradition. The conference will cover a variety of themes including new catalytic materials, theoretical and experimental approaches to improve understanding of kinetics and transport phenomena, and state of the art nanoscale characterization probes to monitor active sites. The conference promotes interactions among established researchers and young scientists. It provides a venue for students to meet, talk to and learn from some of the world leading researchers in the area. It also gives them a platform for displaying their own work during the poster sessions. The informal nature of the meeting, excellent quality of the presentations and posters, and ability to meet many outstanding colleagues makes this an excellent conference.

  1. Calendar of Conferences

    NASA Astrophysics Data System (ADS)

    1996-08-01

    8 - 18 August 1996 International Summer School on Plasma Physics and Technology La Jolla, CA, USA Contact: Mr V Stefan, Institute for Advanced Physics Studies, PO Box 2964, La Jolla, CA 92038, USA. Tel +1-619-456-5737. 26 - 30 August 1996 Joint Varenna - Lausanne International Workshop on Theory of Fusion Plasmas Villa Monastero, Varenna, Italy Contact: Centro di Cultura Villa Monastero, 1 Piazza Venini, 22050 Varenna (Lecco), Italy. Tel +39-341-831261, Fax +39-341-831281. Application and abstract deadline: 15 June 1996. 2 - 5 September 1996 EU - US Workshop on Transport in Fusion Plasmas Villa Monastero, Varenna, Italy Further information: G Gorini, ISPP, 16 Via Celoria, I-20133 Milano, Italy. Tel +39-2-2392637, Fax +39-2-2392205, E-mail ggorini@mi.infn.it. Administrative contact: Centro di Cultura Villa Monastero, 1 Piazza Venini, 22050 Varenna (Lecco), Italy. Tel +39-341-831261, Fax +39-341-831281. Application and abstract deadline: 15 June 1996. 9 - 13 September 1996 International Conference on Plasma Physics Nagoya, Japan Contact: Conference Secretariat, c/o Prof. Hiromu Momota, National Institute for Fusion Science, Nagoya 464-01, Japan. Tel +81-52-789-4260, Fax +81-52-789-1037, E-mail icpp96@nifs.ac.jp. Abstract deadline: 31 March 1996. 16 - 20 September 1996 19th Symposium on Fusion Technology Lisbon, Portugal Contact: Professor Carlos Varandas, Centro de Fusão Nuclear, 1096 Lisboa Codex, Portugal. Fax +351-1-8417819, E-mail cvarandas@cfn.ist.utl.pt. General information will be available via WWW with URL http://www.cfn.ist.utl.pt. 25 - 29 September 1996 Summer University of Plasma Physics Garching, Germany Contact: Ms Ch Stahlberg, Max-Planck-Institut für PlasmaPhysik, Boltzmannstr 2, D-85748 Garching, Germany. Tel +49-89-3299-2232, Fax +49-89-3299-1001. 11 - 15 November 1996 38th Annual Meeting of the Division of Plasma Physics, APS Denver, CO, USA Contact: Dr Richard Hazeltine, University of Texas

  2. Gordon Research Conference on Genetic Toxicology

    SciTech Connect

    Project Director Penelope Jeggo

    2003-02-15

    Genetic toxicology represents a study of the genetic damage that a cell can incur, the agents that induce such damage, the damage response mechanisms available to cells and organisms, and the potential consequences of such damage. Genotoxic agents are abundant in the environment and are also induced endogenously. The consequences of such damage can include carcinogenesis and teratogenesis. An understanding of genetic toxicology is essential to carry out risk evaluations of the impact of genotoxic agents and to assess how individual genetic differences influence the response to genotoxic damage. In recent years, the importance of maintaining genomic stability has become increasingly recognized, in part by the realization that failure of the damage response mechanisms underlies many, if not all, cancer incidence. The importance of these mechanisms is also underscored by their remarkable conservation between species, allowing the study of simple organisms to provide significant input into our understanding of the underlying mechanisms. It has also become clear that the damage response mechanisms interface closely with other aspects of cellular metabolism including replication, transcription and cell cycle regulation. Moreover, defects in many of these mechanisms, as observed for example in ataxia telangiectasia patients, confer disorders with associated developmental abnormalities demonstrating their essential roles during growth and development. In short, while a decade ago, a study of the impact of DNA damage was seen as a compartmentalized area of cellular research, it is now appreciated to lie at the centre of an array of cellular responses of crucial importance to human health. Consequently, this has become a dynamic and rapidly advancing area of research. The Genetic Toxicology Gordon Research Conference is biannual with an evolving change in the emphasis of the meetings. From evaluating the nature of genotoxic chemicals, which lay at the centre of the early

  3. Opioid metabolism.

    PubMed

    Smith, Howard S

    2009-07-01

    Clinicians understand that individual patients differ in their response to specific opioid analgesics and that patients may require trials of several opioids before finding an agent that provides effective analgesia with acceptable tolerability. Reasons for this variability include factors that are not clearly understood, such as allelic variants that dictate the complement of opioid receptors and subtle differences in the receptor-binding profiles of opioids. However, altered opioid metabolism may also influence response in terms of efficacy and tolerability, and several factors contributing to this metabolic variability have been identified. For example, the risk of drug interactions with an opioid is determined largely by which enzyme systems metabolize the opioid. The rate and pathways of opioid metabolism may also be influenced by genetic factors, race, and medical conditions (most notably liver or kidney disease). This review describes the basics of opioid metabolism as well as the factors influencing it and provides recommendations for addressing metabolic issues that may compromise effective pain management. Articles cited in this review were identified via a search of MEDLINE, EMBASE, and PubMed. Articles selected for inclusion discussed general physiologic aspects of opioid metabolism, metabolic characteristics of specific opioids, patient-specific factors influencing drug metabolism, drug interactions, and adverse events.

  4. Opioid Metabolism

    PubMed Central

    Smith, Howard S.

    2009-01-01

    Clinicians understand that individual patients differ in their response to specific opioid analgesics and that patients may require trials of several opioids before finding an agent that provides effective analgesia with acceptable tolerability. Reasons for this variability include factors that are not clearly understood, such as allelic variants that dictate the complement of opioid receptors and subtle differences in the receptor-binding profiles of opioids. However, altered opioid metabolism may also influence response in terms of efficacy and tolerability, and several factors contributing to this metabolic variability have been identified. For example, the risk of drug interactions with an opioid is determined largely by which enzyme systems metabolize the opioid. The rate and pathways of opioid metabolism may also be influenced by genetic factors, race, and medical conditions (most notably liver or kidney disease). This review describes the basics of opioid metabolism as well as the factors influencing it and provides recommendations for addressing metabolic issues that may compromise effective pain management. Articles cited in this review were identified via a search of MEDLINE, EMBASE, and PubMed. Articles selected for inclusion discussed general physiologic aspects of opioid metabolism, metabolic characteristics of specific opioids, patient-specific factors influencing drug metabolism, drug interactions, and adverse events. PMID:19567715

  5. 2010 Tetrapyrroles, Chemistry & Biology of Gordon Research Conference

    SciTech Connect

    Angela Wilks

    2010-07-30

    The objective of the Chemistry & Biology of Tetrapyrroles Gordon Conference is to bring together researchers from diverse disciplines that otherwise would not interact. By bringing biologists, chemists, engineers and clinicians with a common interest in tetrapyrroles the conference provides a forum for cross-disciplinary ideas and collaboration. The perspective provided by biologists, chemists, and clinicians working in fields such as newly discovered defects in human porphyrin metabolism, the myriad of strategies for light harvesting in photosynthetic organisms, novel tetrapyrroles that serve as auxiliary chromophores or enzyme cofactors, synthetic strategies in the design of novel tetrapyrrole scaffolds, and tetrapyrrole based cell signaling and regulatory systems, makes this conference unique in the field. Over the years the growing evidence for the role of tetrapyrroles and their reactive intermediates in cell signaling and regulation has been of increasing importance at this conference. The 2010 conference on Chemistry & Biology of Tetrapyrroles will focus on many of these new frontiers as outlined in the preliminary program listed. Speakers will emphasize unpublished results and new findings in the field. The oral sessions will be followed by the highly interactive afternoon poster sessions. The poster sessions provide all conferees with the opportunity to present their latest research and to exchange ideas in a more informal setting. As in the past, this opportunity will continue during the nightly social gathering that takes place in the poster hall following the evening lectures. All conferees are encouraged to submit and present posters. At the conference the best poster in the areas of biology, chemistry and medicine will be selected by a panel of previous conference chairs.

  6. 10 CFR 2.329 - Prehearing conference.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... place for a conference or conferences before trial. A prehearing conference in a proceeding involving a... proceeding; (10) The setting of a hearing schedule, including any appropriate limitations on the scope and...

  7. 38 CFR 39.33 - Conferences.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... STATES FOR ESTABLISHMENT, EXPANSION, AND IMPROVEMENT, OR OPERATION AND MAINTENANCE, OF VETERANS CEMETERIES Establishment, Expansion, and Improvement Projects Grant Requirements and Procedures § 39.33 Conferences. (a) Predesign conference. A predesign conference is required for all Establishment, Expansion...

  8. 38 CFR 39.33 - Conferences.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... THE ESTABLISHMENT, EXPANSION, AND IMPROVEMENT, OR OPERATION AND MAINTENANCE, OF VETERANS CEMETERIES Establishment, Expansion, and Improvement Projects Grant Requirements and Procedures § 39.33 Conferences. (a) Predesign conference. A predesign conference is required for all Establishment, Expansion, and Improvement...

  9. 38 CFR 39.33 - Conferences.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... THE ESTABLISHMENT, EXPANSION, AND IMPROVEMENT, OR OPERATION AND MAINTENANCE, OF VETERANS CEMETERIES Establishment, Expansion, and Improvement Projects Grant Requirements and Procedures § 39.33 Conferences. (a) Predesign conference. A predesign conference is required for all Establishment, Expansion, and Improvement...

  10. 38 CFR 39.33 - Conferences.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... THE ESTABLISHMENT, EXPANSION, AND IMPROVEMENT, OR OPERATION AND MAINTENANCE, OF VETERANS CEMETERIES Establishment, Expansion, and Improvement Projects Grant Requirements and Procedures § 39.33 Conferences. (a) Predesign conference. A predesign conference is required for all Establishment, Expansion, and Improvement...

  11. 10 CFR 2.329 - Prehearing conference.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... place for a conference or conferences before trial. A prehearing conference in a proceeding involving a... proceeding; (10) The setting of a hearing schedule, including any appropriate limitations on the scope and...

  12. Student-Led Portfolio Conferences.

    ERIC Educational Resources Information Center

    Paulson, F. Leon; Paulson, Pearl R.

    In at least one Oregon school system, student-led conferences have begun to replace traditional report cards. When conferences are well done, parents believe they have learned more about their child's learning and progress than they would through a traditional report card. There is an important additional benefit in that students can rise to the…

  13. SLA at 100: Conference Preview

    ERIC Educational Resources Information Center

    Blumenstein, Lynn

    2009-01-01

    When School Library Association (SLA) convenes its annual conference in Washington, DC, June 14-17, 2009, the association will be celebrating its 100th birthday. This occasion allows for grand gestures--the SLA Salutes! Awards and Leadership Reception will be held in the Library of Congress's Great Hall. The conference also draws upon Washington…

  14. Conference Connections: Rewiring the Circuit

    ERIC Educational Resources Information Center

    Siemens, George; Tittenberger, Peter; Anderson, Terry

    2008-01-01

    Increased openness, two-way dialogue, and blurred distinctions between experts and amateurs have combined with numerous technology tools for dialogue, personal expression, networking, and community formation to "remake" conferences, influencing not only how attendees participate in but also how organizers host conferences today. (Contains 31…

  15. Conference Report: Improving College Teaching.

    ERIC Educational Resources Information Center

    Mayo, C. Douglas; Claxton, Charles S.

    The conference report includes an explanation of the conference plan, a description of the highlights, and descriptions of each session. Among the session topics are: faculty development; instructional improvement in the community college, with emphasis on developmental education; conditions that enhance learning; improving the lecture; evaluating…

  16. Vague Language in Conference Abstracts

    ERIC Educational Resources Information Center

    Cutting, Joan

    2012-01-01

    This study examined abstracts for a British Association for Applied Linguistics conference and a Sociolinguistics Symposium, to define the genre of conference abstracts in terms of vague language, specifically universal general nouns (e.g. people) and research general nouns (e.g. results), and to discover if the language used reflected the level…

  17. Conference Connections: Rewiring the Circuit

    ERIC Educational Resources Information Center

    Siemens, George; Tittenberger, Peter; Anderson, Terry

    2008-01-01

    Increased openness, two-way dialogue, and blurred distinctions between experts and amateurs have combined with numerous technology tools for dialogue, personal expression, networking, and community formation to "remake" conferences, influencing not only how attendees participate in but also how organizers host conferences today. (Contains 31…

  18. SLA at 100: Conference Preview

    ERIC Educational Resources Information Center

    Blumenstein, Lynn

    2009-01-01

    When School Library Association (SLA) convenes its annual conference in Washington, DC, June 14-17, 2009, the association will be celebrating its 100th birthday. This occasion allows for grand gestures--the SLA Salutes! Awards and Leadership Reception will be held in the Library of Congress's Great Hall. The conference also draws upon Washington…

  19. Fifth National Conference on Citizenship.

    ERIC Educational Resources Information Center

    Department of Justice, Washington, DC.

    Presented are general session and discussion group reports from a citizenship conference held in Washington, D.C. in May, 1950. Sponsored by the National Citizenship Committee of the National Education Association and the United States Department of Justice, the conference provided a forum for examination of the functions and duties of American…

  20. Seventh National Conference on Citizenship.

    ERIC Educational Resources Information Center

    Department of Justice, Washington, DC.

    The document presents proceedings from the seventh in a series of annual national citizenship conferences. Held in Washington, D.C. in September, 1952, the conference served as a forum for more than 1,000 educational, political, business, religious, labor, civic, and communications leaders to explore functions and duties of American citizenship.…

  1. The Second National Conference Summary.

    ERIC Educational Resources Information Center

    Chai, Carolyn

    In this summary of the 1978 National Conference on Asians in America and Asian Americans, conference proceedings, as well as papers and panel discussions, are briefly outlined. Workshops on foreign policy, immigration, Asian identity, education and employment, Indo-Chinese in the United States, teaching English to immigrants, racism and…

  2. Vague Language in Conference Abstracts

    ERIC Educational Resources Information Center

    Cutting, Joan

    2012-01-01

    This study examined abstracts for a British Association for Applied Linguistics conference and a Sociolinguistics Symposium, to define the genre of conference abstracts in terms of vague language, specifically universal general nouns (e.g. people) and research general nouns (e.g. results), and to discover if the language used reflected the level…

  3. Galaxy Conference on Adult Education.

    ERIC Educational Resources Information Center

    Association of Univ. Evening Colleges, Norman, OK.

    The Association of University Evening Colleges held its 1969 conference in conjunction with the Galaxy Conference on Adult Education. Over 4,000 people representing 21 different organizations interested in adult education attended. Presentations dealt with the areas: learning to change, imperatives for action, the Nixon administration and…

  4. THE PREPLANNING TITLE VII CONFERENCE.

    ERIC Educational Resources Information Center

    KIEFFER, ROBERT DE

    THIS REPORT IS A TRANSCRIPT OF PROCEEDINGS OF A PLANNING CONFERENCE HELD AT BOULDER, COLORADO IN SEPTEMBER 1958 FOR THE PURPOSE OF DESIGNING A LARGER CONFERENCE IN APRIL 1960. SPECIFICALLY THIS WOULD DEAL WITH MORE EFFECTIVE UTILIZATION OF TELEVISION, RADIO, MOTION PICTURES AND RELATED MEDIA FOR EDUCATIONAL PURPOSES IN THE MOUNTAIN PLAINS STATES…

  5. Beating the Futures Conference Game.

    ERIC Educational Resources Information Center

    Simmonds, W. H. Clive

    1983-01-01

    Conference survival tips include: (1) noting the different kinds of speakers, their strengths and weaknesses; (2) discovering the reasons for often apparent cross-talk and misunderstanding; and (3) using the concept of futuring to gain ideas as to what can be done after the conference ends. (RM)

  6. 2012 Gordon Research Conference on Cellular and Molecular Fungal Biology, Final Progress Report

    SciTech Connect

    Berman, Judith

    2012-06-22

    The Gordon Research Conference on Cellular and Molecular Fungal Biology was held at Holderness School, Holderness New Hampshire, June 17 - 22, 2012. The 2012 Gordon Conference on Cellular and Molecular Fungal Biology (CMFB) will present the latest, cutting-edge research on the exciting and growing field of molecular and cellular aspects of fungal biology. Topics will range from yeast to filamentous fungi, from model systems to economically important organisms, and from saprophytes and commensals to pathogens of plants and animals. The CMFB conference will feature a wide range of topics including systems biology, cell biology and morphogenesis, organismal interactions, genome organisation and regulation, pathogenesis, energy metabolism, biomass production and population genomics. The Conference was well-attended with 136 participants. Gordon Research Conferences does not permit publication of meeting proceedings.

  7. Plant Molecular Biology 2008 Gordon Research Conference - July 13-18, 2008

    SciTech Connect

    Richard M. Amasino

    2009-08-28

    The Plant Molecular Biology Conference has traditionally covered a breadth of exciting topics and the 2008 conference will continue in that tradition. There will be sessions on metabolism; new methods to study genomes, proteomes and metabolomes; plant-microbe interactions; plant hormones; epigenetics. A new topic for the conference this year will be bioenergy. Thus this conference will bring together a range of disciplines to foster the exchange ideas and to permit the participants to learn of the latest developments and ideas in diverse areas of plant biology. The conference provides an excellent opportunity for individuals to discuss their research because additional speakers in each session will be selected from submitted abstracts. There will also be a poster session each day for a two-hour period prior to dinner.

  8. Summary of 1990 Code Conference

    SciTech Connect

    Cooper, R.K.; Chan, Kwok-Chi D.

    1990-01-01

    The Conference on Codes and the Linear Accelerator Community was held in Los Alamos in January 1990, and had approximately 100 participants. This conference was the second in a series which has as its goal the exchange of information about codes and code practices among those writing and actually using these codes for the design and analysis of linear accelerators and their components. The first conference was held in San Diego in January 1988, and concentrated on beam dynamics codes and Maxwell solvers. This most recent conference concentrated on 3-D codes and techniques to handle the large amounts of data required for three-dimensional problems. In addition to descriptions of codes, their algorithms and implementations, there were a number of paper describing the use of many of the codes. Proceedings of both these conferences are available. 3 refs., 2 tabs.

  9. Metabolic acidosis.

    PubMed

    Lim, Salim

    2007-01-01

    Acute metabolic acidosis is frequently encountered in critically ill patients. Metabolic acidosis can occur as a result of either the accumulation of endogenous acids that consumes bicarbonate (high anion gap metabolic acidosis) or loss of bicarbonate from the gastrointestinal tract or the kidney (hyperchloremic or normal anion gap metabolic acidosis). The cause of high anion gap metabolic acidosis includes lactic acidosis, ketoacidosis, renal failure and intoxication with ethylene glycol, methanol, salicylate and less commonly with pyroglutamic acid (5-oxoproline), propylene glycole or djenkol bean (gjenkolism). The most common causes of hyperchloremic metabolic acidosis are gastrointestinal bicarbonate loss, renal tubular acidosis, drugs-induced hyperkalemia, early renal failure and administration of acids. The appropriate treatment of acute metabolic acidosis, in particular organic form of acidosis such as lactic acidosis, has been very controversial. The only effective treatment for organic acidosis is cessation of acid production via improvement of tissue oxygenation. Treatment of acute organic acidosis with sodium bicarbonate failed to reduce the morbidity and mortality despite improvement in acid-base parameters. Further studies are required to determine the optimal treatment strategies for acute metabolic acidosis.

  10. Eastern Pacific Ocean Conference

    NASA Astrophysics Data System (ADS)

    The promotion of interaction among investigators of all oceanographic disciplines studying the eastern Pacific Ocean was the goal of the 1990 Eastern Pacific Ocean Conference (EPOC), held October 17-19 on the snow-covered slopes of Mt. Hood, Oreg. Thirty oceanographers representing all disciplines attended.Dick Barber, Duke University Marine Lab, Beaufort, N.C., chaired a session on the eastern equatorial Pacific Ocean, emphasizing issues related to biological activity. Steve Ramp of the Naval Postgraduate School in Montery, Calif., chaired a session on recent results from northern and central California experiments. On October 19, following an early morning earthquake, a business meeting and discussions regarding a collaboration in future experiments were held.

  11. 2006 environmental controls conference

    SciTech Connect

    2006-07-01

    The two topics covered at the conference were: selective catalytic reduction (SCR) and selection non-catalytic reduction (SNCR) for NOx control, and techniques for managing sulfur trioxide. A total of 45 presentations are summarized on the NETL website of which 22 are available in full. These include keynote addresses for each of the two major topics. In addition four poster papers are listed. The papers are arranged in sections headed: regulatory considerations; overview of SCR/SNCR; managing SCR catalysts; gas monitoring and analysis; predictive performance tools; non-coal applications; layered SCR; flow distribution and modeling; hybrid systems; innovative applications; SO{sub 2} conversion to SO{sub 3}; SO{sub 3} overview; acid gas control issues; sorbent injection for acid gas migration; and effects of SO{sub 3} on mercury control.

  12. Expedition 38 Press Conference

    NASA Image and Video Library

    2013-11-06

    Expedition 38 Flight Engineer Koichi Wakata of the Japan Aerospace Exploration Agency is seen in quarantine, behind glass, during the final press conference held a day ahead of his launch with fellow crew mates, Expedition 38 Soyuz Commander Mikhail Tyurin of Roscosmos, and, Flight Engineer Rick Mastracchio of NASA, to the International Space Station, Wednesday, Nov. 6, 2013 at the Cosmonaut Hotel in Baikonur, Kazakhstan. An Olympic torch that will be launched with the crew for a four-day visit to the station is seen on the left. The torch will return to Earth with another trio of station residents on Nov. 11 and will be part of the torch relay that ends with the lighting of the flame at the Fisht Stadium in Sochi, Russia Feb. 7 to mark the opening of the 2014 Winter Olympics. Photo Credit: (NASA/Bill Ingalls)

  13. Expedition 38 Press Conference

    NASA Image and Video Library

    2013-11-06

    Expedition 38 Flight Engineer Rick Mastracchio of NASA talks, while in quarantine behind glass, during the final press conference held a day ahead of his launch with fellow crew mates, Soyuz Commander Mikhail Tyurin of Roscosmos, and, Flight Engineer Koichi Wakata of the Japan Aerospace Exploration Agency, to the International Space Station, Wednesday, Nov. 6, 2013 at the Cosmonaut Hotel in Baikonur, Kazakhstan. An Olympic torch that will be launched with the crew for a four-day visit to the station is seen next to Mastracchio. The torch will return to Earth with another trio of station residents on Nov. 11 and will be part of the torch relay that ends with the lighting of the flame at the Fisht Stadium in Sochi, Russia Feb. 7 to mark the opening of the 2014 Winter Olympics. Photo Credit: (NASA/Bill Ingalls)

  14. ISMB Conference Proceedings

    SciTech Connect

    Teresa, Gaasterand; Martin, Vingron

    2011-07-01

    This special issue comprises the papers accepted for presentation at the 19th Annual International Conference on Intelligent Systems for Molecular Biology, joint with the 10th European Conference on Computational Biology, an official conference of the International Society for Computational Biology (ISCB; http://www.iscb.org). ISMB/ECCB 2011 (http://www.iscb.org/ismb2011/) will take place in Vienna, Austria, from July 17 through July 19, 2011; preceded during July 14–16 by eight 1- or 2- day Special Interest Group (SIG) meetings, three satellite meetings and nine half-day tutorials; and followed by two additional satellite meetings. The 48 papers in this volume were selected from 258 submitted papers. Submitted papers were assigned to 13 areas. Area Chairs led each topic area by selecting their area's program committee and overseeing the reviewing process. Many Area Chairs were new compared to 2010, and two completely new areas were added in 2011, ‘Data Visualization’ and ‘Mass Spectrometry and Proteomics’. Six papers for which Area Chairs were in conflict were reviewed under a ‘Conflicts Management’ section headed by the Proceedings Chairs; one such paper was accepted in ‘Bioimaging’. Areas, co-chairs and acceptance information are listed in Table 1. Compared to prior years, five mature topic areas had steady submissions, ‘Evolution and Comparative Genomics’, ‘Gene Regulation and Transcriptomics’, ‘Protein Structure and Function’, ‘Sequence Analysis’, ‘Text Mining’. Two areas newer to ISMB were underrepresented this year, ‘Bioimaging’ and ‘Disease Models and Epidemiology’. One area doubled, ‘Applied Bioinformatics’, renamed from last year's ‘Other Bioinformatics Applications’; and one tripled, ‘Protein Interactions and Molecular Networks’. Across the areas, 326 members of the bioinformatics community provided reviews. Most papers received three reviews and several received four or more. There was

  15. Conference Report: Power and Energy Society Annual Conference

    NASA Astrophysics Data System (ADS)

    Yorino, Naoto; Mori, Hiroyuki

    The 19th Power & Energy Society Annual Conference was held on September 24-26, 2008 at Hiroshima University. The total number of technical papers was 415 and 53 sessions (52 oral sessions and 1 poster session) were organized. A panel discussion, a special lecture, technical exhibitions and technical tours were also organized. All events were very well attended and the final enrollment attained to 954 registrations. The conference has been successfully closed by the great contribution of all participants. In this article, the outline of the conference is reported.

  16. Computational Biology Support: RECOMB Conference Series (Conference Support)

    SciTech Connect

    Michael Waterman

    2006-06-15

    This funding was support for student and postdoctoral attendance at the Annual Recomb Conference from 2001 to 2005. The RECOMB Conference series was founded in 1997 to provide a scientific forum for theoretical advances in computational biology and their applications in molecular biology and medicine. The conference series aims at attracting research contributions in all areas of computational molecular biology. Typical, but not exclusive, the topics of interest are: Genomics, Molecular sequence analysis, Recognition of genes and regulatory elements, Molecular evolution, Protein structure, Structural genomics, Gene Expression, Gene Networks, Drug Design, Combinatorial libraries, Computational proteomics, and Structural and functional genomics. The origins of the conference came from the mathematical and computational side of the field, and there remains to be a certain focus on computational advances. However, the effective use of computational techniques to biological innovation is also an important aspect of the conference. The conference had a growing number of attendees, topping 300 in recent years and often exceeding 500. The conference program includes between 30 and 40 contributed papers, that are selected by a international program committee with around 30 experts during a rigorous review process rivaling the editorial procedure for top-rate scientific journals. In previous years papers selection has been made from up to 130--200 submissions from well over a dozen countries. 10-page extended abstracts of the contributed papers are collected in a volume published by ACM Press and Springer, and are available at the conference. Full versions of a selection of the papers are published annually in a special issue of the Journal of Computational Biology devoted to the RECOMB Conference. A further point in the program is a lively poster session. From 120-300 posters have been presented each year at RECOMB 2000. One of the highlights of each RECOMB conference is a

  17. International multidisciplinary consensus conference on multimodality monitoring: cerebral metabolism.

    PubMed

    Hutchinson, Peter; O'Phelan, Kristine

    2014-12-01

    Microdialysis is a powerful technique, which enables the chemistry of the extracellular space to be measured directly. Applying this technique to patients in neurointensive care has increased our understanding of the pathophysiology of traumatic brain injury and spontaneous hemorrhage. In parallel, it is important to determine the place of microdialysis in assisting in the management of patients on an individual intention to treat basis. This is made possible by the availability of analyzers which can measure the concentration of glucose, pyruvate, lactate, and glutamate at the bedside. Samples can then be stored for later analysis of other substrate and metabolites e.g., other amino acids and cytokines. The objective of this paper is to review the fundamental literature pertinent to the clinical application of microdialysis in neurointensive care and to give recommendations on how the technique can be applied to assist in patient management and contribute to outcome. A literature search detected 1,933 publications of which 55 were used for data abstraction and analysis. The role of microdialysis was evaluated in three conditions (traumatic brain injury, subarachnoid hemorrhage, and intracerebral hemorrhage) and recommendations focused on three fundamental areas (relationship to outcome, application of microdialysis to guide therapy, and the ability of microdialysis to predict secondary deterioration).

  18. PREFACE: Quark Matter 2006 Conference Quark Matter 2006 Conference

    NASA Astrophysics Data System (ADS)

    Ma, Yu-Gang; Wang, En-Ke; Cai, Xu; Huang, Huan-Zhong; Wang, Xin-Nian; Zhu, Zhi-Yuan

    2007-07-01

    The Quark Matter 2006 conference was held on 14-20 November 2006 at the Shanghai Science Hall of the Shanghai Association of Sciences and Technology in Shanghai, China. It was the 19th International Conference on Ultra-Relativistic Nucleus-Nucleus Collisions. The conference was organized jointly by SINAP (Shanghai Institute of Applied Physics, Chinese Academy of Sciences (CAS)) and CCNU (Central China Normal University, Wuhan). Over 600 scientists from 32 countries in five continents attended the conference. This is the first time that China has hosted such a premier conference in the field of relativistic heavy-ion collisions, an important event for the Chinese high energy nuclear physics community. About one half of the conference participants are junior scientists—a clear indication of the vigor and momentum for this field, in search of the fundamental nature of the nuclear matter at extreme conditions. Professor T D Lee, honorary chair of the conference and one of the founders of the quark matter research, delivered an opening address with his profound and philosophical remarks on the recent discovery of the nature of strongly-interacting quark-gluon-plasma (sQGP). Professor Hongjie Xu, director of SINAP, gave a welcome address to all participants on behalf of the two hosting institutions. Dr Peiwen Ji, deputy director of the Mathematics and Physics Division of the Natural Science Foundation of China (NSFC), also addressed the conference participants and congratulated them on the opening of the conference. Professor Mianheng Jiang, vice president of the Chinese Academy of Sciences (CAS), gave a concise introduction about the CAS as the premier research institution in China. He highlighted continued efforts at CAS to foster international collaborations between China and other nations. The Quark Matter 2006 conference is an example of such a successful collaboration between high energy nuclear physicists in China and other nations all over the world. The

  19. 33rd Actinide Separations Conference

    SciTech Connect

    McDonald, L M; Wilk, P A

    2009-05-04

    Welcome to the 33rd Actinide Separations Conference hosted this year by the Lawrence Livermore National Laboratory. This annual conference is centered on the idea of networking and communication with scientists from throughout the United States, Britain, France and Japan who have expertise in nuclear material processing. This conference forum provides an excellent opportunity for bringing together experts in the fields of chemistry, nuclear and chemical engineering, and actinide processing to present and discuss experiences, research results, testing and application of actinide separation processes. The exchange of information that will take place between you, and other subject matter experts from around the nation and across the international boundaries, is a critical tool to assist in solving both national and international problems associated with the processing of nuclear materials used for both defense and energy purposes, as well as for the safe disposition of excess nuclear material. Granlibakken is a dedicated conference facility and training campus that is set up to provide the venue that supports communication between scientists and engineers attending the 33rd Actinide Separations Conference. We believe that you will find that Granlibakken and the Lake Tahoe views provide an atmosphere that is stimulating for fruitful discussions between participants from both government and private industry. We thank the Lawrence Livermore National Laboratory and the United States Department of Energy for their support of this conference. We especially thank you, the participants and subject matter experts, for your involvement in the 33rd Actinide Separations Conference.

  20. PREFACE: The Irago Conference 2012

    NASA Astrophysics Data System (ADS)

    Sandhu, Adarsh; Okada, Hiroshi

    2013-04-01

    The Irago Conference 2012 - 360 degree outlook on critical scientific and technological challenges for a sustainable society Organized by the Electronics-Inspired Interdisciplinary Research Institute (EIIRIS) at Toyohashi University of Technology, the Irago Conference, held recently (15-16 November) in Aichi, Japan, aimed to enhance mutual understanding between scientists, engineers and policymakers. Over 180 participants tackled topics ranging from energy and natural resources to public health and disaster prevention. The 360-degree outlook of the conference impressed speakers and guests. ''This conference has been extremely informative,'' noted Robert Gellar from the University of Tokyo. ''A unique conference with experts from a range of backgrounds,'' agreed Uracha Ruktanonchai from the National Nanotechnology Center (NANOTEC) in Thailand. Similarly, G P Li, professor of electrical engineering and computer science at the University of California Irvine commented that he had been ''able to think the unthinkable'' as a range of topics came together. The conference was streamed live on Ustream to ensure that researchers from across the world could benefit from thought-provoking presentations examining global issues such as energy, disaster mitigation and nanotechnology. ''This was wonderful,'' said Oussama Khatib from Stanford University, ''A good recipe of speakers from such a range of backgrounds.'' Manuscripts submitted to the organizers were peer-reviewed, and the papers in this proceedings were accepted for Journal of Physics: Conference Series. In addition to the formal speaker programme, graduate-student sessions provided a platform for graduate students to describe their latest findings as oral presentations. A series of excursions to relevant locations, such as the Tahara megasolar region under construction and a local car-manufacturing factory, gave participants the opportunity to further consider practical applications of their research in industry

  1. DOE Workshop at Tapia Conference

    SciTech Connect

    Taylor, Valerie

    2015-02-19

    The DE-SC0013568 DOE Grant, in the amount of $11,822.79, was used to support five doctoral students from underrepresented groups to attend the 2015 Richard Tapia Celebration of Diversity in Computing Conference, held February 18-21 in Boston, MA. Each scholarship was approximately $1200 to cover conference registration, travel, and lodging for the duration of the conference. The remaining $5,822.79 was used to support a DOE Breakfast Workshop during breakfast on Thursday, February 19. The Breakfast supported approximately 140 graduate students from underrepresented groups to learn about the different career opportunities at the different DOE National Laboratories.

  2. Mechanics of Textile Composites Conference

    SciTech Connect

    Poe, C.C. Jr.; Harris, C.E.

    1995-10-01

    This document is a compilation of papers presented at the Mechanics of Textile Composites Conference in Hampton, Virginia, December 6-8, 1994. This conference was the culmination of a 3-year program that was initiated by NASA late in 1990 to develop mechanics of textile composites in support of the NASA Advanced Composites Technology Program (ACT). The goal of the program was to develop mathematical models of textile preform materials and test methods to facilitate structural analysis and design. Participants in the program were from NASA, academia, and industry. Separate abstracts have been submitted to the database for articles from this conference.

  3. Topical conference: Opportunities in biology for physicists. Conference summary

    SciTech Connect

    2002-12-16

    The conference was aimed at early career physicists who were interested in exploring the possibilities of working at the interface between physics and biology, in particular, graduate students and postdocs considering applying the methods of physics to biological research. Areas of major importance were genomics and evolution, biological networks, biomolecular dynamics, high-resolution imaging of living cells, and technologies for biological investigation. A total of 205 persons attended the conference.

  4. PREFACE: Quark Matter 2006 Conference

    NASA Astrophysics Data System (ADS)

    Ma, Yu-Gang; Wang, En-Ke; Cai, Xu; Huang, Huan-Zhong; Wang, Xin-Nian; Zhu, Zhi-Yuan

    2007-07-01

    The Quark Matter 2006 conference was held on 14 20 November 2006 at the Shanghai Science Hall of the Shanghai Association of Sciences and Technology in Shanghai, China. It was the 19th International Conference on Ultra-Relativistic Nucleus Nucleus Collisions. The conference was organized jointly by SINAP (Shanghai Institute of Applied Physics, Chinese Academy of Sciences (CAS)) and CCNU (Central China Normal University, Wuhan). Over 600 scientists from 32 countries in five continents attended the conference. This is the first time that China has hosted such a premier conference in the field of relativistic heavy-ion collisions, an important event for the Chinese high energy nuclear physics community. About one half of the conference participants are junior scientists—a clear indication of the vigor and momentum for this field, in search of the fundamental nature of the nuclear matter at extreme conditions. Professor T D Lee, honorary chair of the conference and one of the founders of the quark matter research, delivered an opening address with his profound and philosophical remarks on the recent discovery of the nature of strongly-interacting quark-gluon-plasma (sQGP). Professor Hongjie Xu, director of SINAP, gave a welcome address to all participants on behalf of the two hosting institutions. Dr Peiwen Ji, deputy director of the Mathematics and Physics Division of the Natural Science Foundation of China (NSFC), also addressed the conference participants and congratulated them on the opening of the conference. Professor Mianheng Jiang, vice president of the Chinese Academy of Sciences (CAS), gave a concise introduction about the CAS as the premier research institution in China. He highlighted continued efforts at CAS to foster international collaborations between China and other nations. The Quark Matter 2006 conference is an example of such a successful collaboration between high energy nuclear physicists in China and other nations all over the world. The

  5. Metabolic Syndrome

    MedlinePlus

    ... cause of metabolic syndrome. The cause might be insulin resistance. Insulin is a hormone your body produces to help ... into energy for your body. If you are insulin resistant, too much sugar builds up in your ...

  6. Metabolic neuropathies

    MedlinePlus

    ... as porphyria Severe infection throughout the body ( sepsis ) Thyroid disease Vitamin deficiencies (including vitamins B12 , B6 , E , and B1 ) Some metabolic disorders are passed down through families (inherited), while ...

  7. Metabolic Myopathies

    MedlinePlus

    ... muscles. Metabolic refers to chemical reactions that provide energy, nutrients and substances necessary for health and growth. ... occur when muscle cells don’t get enough energy. Without enough energy, the muscle lacks enough fuel ...

  8. Metabolic Disorders

    MedlinePlus

    Metabolism is the process your body uses to get or make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Chemicals in your digestive system break the food parts down into sugars and ...

  9. Metabolic Myopathies

    MedlinePlus

    ... muscles. Metabolic refers to chemical reactions that provide energy, nutrients and substances necessary for health and growth. ... occur when muscle cells don’t get enough energy. Without enough energy, the muscle lacks enough fuel ...

  10. 17 CFR 201.221 - Prehearing conference.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Prehearing conference. 201.221... Rules of Practice Initiation of Proceedings and Prehearing Rules § 201.221 Prehearing conference. (a) Purposes of conference. The purposes of a prehearing conference include, but are not limited to:...

  11. 49 CFR 511.21 - Prehearing conferences.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 6 2010-10-01 2010-10-01 false Prehearing conferences. 511.21 Section 511.21...; Interlocutory Appeals; Summary Judgment; Settlement § 511.21 Prehearing conferences. (a) When held. (1) A prehearing conference shall be held in person or by conference telephone call, except in...

  12. 10 CFR 205.171 - Conferences.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Conferences. 205.171 Section 205.171 Energy DEPARTMENT OF ENERGY OIL ADMINISTRATIVE PROCEDURES AND SANCTIONS Conferences, Hearings, and Public Hearings § 205.171 Conferences. (a) The DOE in its discretion may direct that a conference be convened, on its own initiative...

  13. 24 CFR 26.39 - Prehearing conferences.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Prehearing conferences. 26.39... § 26.39 Prehearing conferences. (a) The ALJ may schedule prehearing conferences as appropriate. (b) Upon the motion of any party or sua sponte, the ALJ may schedule a prehearing conference at...

  14. 14 CFR 302.414 - Prehearing conference.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Prehearing conference. 302.414 Section 302... Prehearing conference. A prehearing conference may be held in an enforcement proceeding whenever the... prehearing conference is held, it shall be conducted in accordance with § 302.22....

  15. 20 CFR 498.206 - Prehearing conferences.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Prehearing conferences. 498.206 Section 498... RECOMMENDED EXCLUSIONS § 498.206 Prehearing conferences. (a) The ALJ will schedule at least one prehearing conference, and may schedule additional prehearing conferences as appropriate, upon reasonable notice to...

  16. 33 CFR 20.501 - Conferences.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Conferences. 20.501 Section 20... PRACTICE, PROCEDURE, AND EVIDENCE FOR FORMAL ADMINISTRATIVE PROCEEDINGS OF THE COAST GUARD Conferences and Settlements § 20.501 Conferences. (a) Any party may by motion request a conference. (b) The ALJ may direct...

  17. 47 CFR 1.956 - Settlement conferences.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Settlement conferences. 1.956 Section 1.956... Applications and Proceedings Application Requirements and Procedures § 1.956 Settlement conferences. Parties... their attorneys to appear before it for a conference. (a) The purposes of such conferences are: (1)...

  18. 28 CFR 71.19 - Prehearing conferences.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Prehearing conferences. 71.19 Section 71... § 71.19 Prehearing conferences. (a) The ALJ may schedule prehearing conferences as appropriate. (b) Upon the motion of any party, the ALJ shall schedule at least one prehearing conference at a...

  19. 42 CFR 3.512 - Prehearing conferences.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Prehearing conferences. 3.512 Section 3.512 Public... ORGANIZATIONS AND PATIENT SAFETY WORK PRODUCT Enforcement Program § 3.512 Prehearing conferences. (a) The ALJ must schedule at least one prehearing conference, and may schedule additional prehearing conferences...

  20. 27 CFR 70.418 - Conferences.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Conferences. 70.418... Beer § 70.418 Conferences. Any person desiring a conference with TTB, relative to any matter arising in connection with such person's operations, will be accorded such a conference upon request. No...

  1. 2 CFR 801.1112 - Conference.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Conference. 801.1112 Section 801.1112 Grants... Subpart for OMB Guidance at 2 CFR Part 180). § 801.1112 Conference. Upon receipt of a request for a conference, the official imposing the sanction shall arrange such a conference with the participant...

  2. 20 CFR 405.330 - Prehearing conferences.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Prehearing conferences. 405.330 Section 405... INITIAL DISABILITY CLAIMS Administrative Law Judge Hearing § 405.330 Prehearing conferences. (a)(1) The... conference if he or she finds that such a conference would facilitate the hearing or the decision on...

  3. 10 CFR 1003.61 - Conferences.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Conferences. 1003.61 Section 1003.61 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) OFFICE OF HEARINGS AND APPEALS PROCEDURAL REGULATIONS Conferences and Hearings § 1003.61 Conferences. (a) The OHA in its discretion may direct that a conference be convened,...

  4. 10 CFR 1013.19 - Prehearing conferences.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Prehearing conferences. 1013.19 Section 1013.19 Energy... conferences. (a) The ALJ may schedule prehearing conferences as appropriate. (b) Upon the motion of any party, the ALJ shall schedule at least one prehearing conference at a reasonable time in advance of...

  5. 20 CFR 405.366 - Posthearing conferences.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Posthearing conferences. 405.366 Section 405... INITIAL DISABILITY CLAIMS Administrative Law Judge Hearing § 405.366 Posthearing conferences. (a) The... conference to facilitate the hearing decision. A posthearing conference normally will be held by...

  6. 22 CFR 521.19 - Prehearing conferences.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Prehearing conferences. 521.19 Section 521.19... § 521.19 Prehearing conferences. (a) The ALJ may schedule prehearing conferences as appropriate. (b) Upon the motion of any party, the ALJ shall schedule at least one prehearing conference at a...

  7. 10. international mouse genome conference

    SciTech Connect

    Meisler, M.H.

    1996-12-31

    Ten years after hosting the First International Mammalian Genome Conference in Paris in 1986, Dr. Jean-Louis Guenet presided over the Tenth Conference at the Pasteur Institute, October 7--10, 1996. The 1986 conference was a satellite to the Human Gene Mapping Workshop and had approximately 50 attendees. The 1996 meeting was attended by 300 scientists from around the world. In the interim, the number of mapped loci in the mouse increased from 1,000 to over 20,000. This report contains a listing of the program and its participants, and two articles that review the meeting and the role of the laboratory mouse in the Human Genome project. More than 200 papers were presented at the conference covering the following topics: International mouse chromosome committee meetings; Mutant generation and identification; Physical and genetic maps; New technology and resources; Chromatin structure and gene regulation; Rate and hamster genetic maps; Informatics and databases; and Quantitative trait analysis.

  8. Climate Leadership Awards and Conference

    EPA Pesticide Factsheets

    The seventh annual Climate Leadership Awards Dinner will be held during the 2018 Climate Leadership Conference; the event publicly recognize individuals and organizations for their outstanding leadership in reducing greenhouse gas emissions.

  9. 2011 Community Involvement Training Conference

    EPA Pesticide Factsheets

    A dynamic training conference that brings together more than 450 people from EPA and the Agency’s partners and stakeholders who plan and implement environmental community involvement, partnership, stewardship, outreach, and education programs.

  10. 2009 Community Involvement Training Conference

    EPA Pesticide Factsheets

    A dynamic training conference that brings together more than 450 people from EPA and the Agency’s partners and stakeholders who plan and implement environmental community involvement, partnership, stewardship, outreach, and education programs.

  11. 2013 Community Involvement Training Conference

    EPA Pesticide Factsheets

    A dynamic training conference that brings together more than 450 people from EPA and the Agency’s partners and stakeholders who plan and implement environmental community involvement, partnership, stewardship, outreach, and education programs.

  12. 2007 Community Involvement Training Conference

    EPA Pesticide Factsheets

    A dynamic training conference that brings together more than 450 people from EPA and the Agency’s partners and stakeholders who plan and implement environmental community involvement, partnership, stewardship, outreach, and education programs.

  13. 2006 Community Involvement Training Conference

    EPA Pesticide Factsheets

    A dynamic training conference that brings together more than 450 people from EPA and the Agency’s partners and stakeholders who plan and implement environmental community involvement, partnership, stewardship, outreach, and education programs.

  14. Expedition 21 Prelaunch Press Conference

    NASA Image and Video Library

    2009-09-28

    Expedition 21 Flight Engineer Jeffrey N. Williams answers questions from behind glass during a press conference on Tuesday, Sept. 29, 2009 at the Cosmonaut Hotel in Baikonur, Kazakhstan. Photo Credit: (NASA/Bill Ingalls)

  15. 2015 Community Involvement Training Conference

    EPA Pesticide Factsheets

    A dynamic training conference that brings together more than 450 people from EPA and the Agency’s partners and stakeholders who plan and implement environmental community involvement, partnership, stewardship, outreach, and education programs.

  16. EPA Community Involvement Training Conferences

    EPA Pesticide Factsheets

    A dynamic training conference that brings together more than 450 people from EPA and the Agency’s partners and stakeholders who plan and implement environmental community involvement, partnership, stewardship, outreach, and education programs.

  17. Hubble Servicing Mission Press Conference

    NASA Image and Video Library

    2009-04-22

    Mike Klenlen, the Hubble Deputy Project Manager, speaks during a press conference on the upcoming Hubble Space Telescope servicing mission, Thursday, April 23, 2009, at NASA Headquarters in Washington. Photo Credit: (NASA/Paul. E. Alers)

  18. Hubble Servicing Mission Press Conference

    NASA Image and Video Library

    2009-04-22

    Preston Burch, Hubble Program Manager, speaks during a press conference on the upcoming Hubble Space Telescope servicing mission, Thursday, April 23, 2009, at NASA Headquarters in Washington. Photo Credit: (NASA/Paul. E. Alers)

  19. International Conference on Human Relations.

    DTIC Science & Technology

    2007-11-02

    Festinger , Sherif, Ex, Rohrer, Pinto, Singh, and Mailhiot. One outcome of the Conference was the formation of a working committee to establish an International Documentation and Information Center for the field of Human Relations.

  20. CNIO cancer conference: targeted search for anticancer drugs.

    PubMed

    Fischer, Peter M

    2003-06-01

    The topics discussed at the conference covered many aspects of cancer research, from the genetic search for new targets, target validation and drug discovery, all the way to preclinical and clinical development of oncology drugs. Here the presentations on new metabolic, angiogenic, cell cycle and other molecular targets, as well as recent developments with experimental drugs with action on some of these targets, are summarised. Particular emphasis is placed on the emerging realisation that changes in the metabolic phenotype lie at the heart of cellular transformation. New insights into the biological links between cancer cell metabolism and the balance between survival and death signalling are likely to lead to the identification of a new category of anticancer targets.

  1. 9. international mouse genome conference

    SciTech Connect

    1995-12-31

    This conference was held November 12--16, 1995 in Ann Arbor, Michigan. The purpose of this conference was to provide a multidisciplinary forum for exchange of state-of-the-art information on genetic mapping in mice. This report contains abstracts of presentations, focusing on the following areas: mutation identification; comparative mapping; informatics and complex traits; mutagenesis; gene identification and new technology; and genetic and physical mapping.

  2. Ninth International Conference on Sarcoidosis.

    DTIC Science & Technology

    1981-10-15

    AC-AIOb 379 OFFICE OF NAVAL RESEARCH LONDON (ENGLAND) F/S 6/5 NINTH INTERNATIONAL CONFERENCE ON SARCOIDOSIS .(U) OCT 81 1 C ROSE UNCLASSIFIED ONRLC...INTERNATIONAL CONFERENCE ON SARCOIDOSIS S. PERFORMING ORG. REPORT NUMBER 7. AUTHOR(e) I. CONTRACT OR GRANT NUMBER(a) JOHN C. ROSE 9. PERFORMING...SUPPLEMENTARY NOTES 19. KEY WORDS (Continue on reverse side if necesery mnd identify by block nuatbor) ACE lymphocytes alveolitis sarcoidosis

  3. Eighteen Years of the Great Lakes Regional Counseling Psychology Conference: Revisiting the Need for Regional Conferences

    ERIC Educational Resources Information Center

    Delgado-Romero, Edward A.; Bowman, Sharon L.; Gerstein, Lawrence H.

    2006-01-01

    The Great Lakes Regional Conference on Counseling Psychology is the only conference to continuously fulfill the 1987 mandate issued by Division 17 for regional counseling conferences. The rationale for regional conferences is reviewed, and the 18-year history of the Great Lakes Regional Conference is examined. The authors conclude by noting the…

  4. Eighteen Years of the Great Lakes Regional Counseling Psychology Conference: Revisiting the Need for Regional Conferences

    ERIC Educational Resources Information Center

    Delgado-Romero, Edward A.; Bowman, Sharon L.; Gerstein, Lawrence H.

    2006-01-01

    The Great Lakes Regional Conference on Counseling Psychology is the only conference to continuously fulfill the 1987 mandate issued by Division 17 for regional counseling conferences. The rationale for regional conferences is reviewed, and the 18-year history of the Great Lakes Regional Conference is examined. The authors conclude by noting the…

  5. NASA Microgravity Materials Science Conference

    NASA Technical Reports Server (NTRS)

    Gillies, D. C. (Compiler); McCauley, D. E. (Compiler)

    1999-01-01

    The Microgravity Materials Science Conference was held July 14-16, 1998 at the Von Braun Center in Huntsville, AL. It was organized by the Microgravity Materials Science Discipline Working Group, sponsored by the Microgravity Research Division at NASA Headquarters, and hosted by the NASA Marshall Space Flight Center and the Alliance for Microgravity Materials Science and Applications. It was the third NASA conference of this type in the microgravity materials science discipline. The microgravity science program sponsored approximately 125 investigations and 100 principal investigators in FY98, almost all of whom made oral or poster presentations at this conference. The conference's purpose was to inform the materials science community of research opportunities in reduced gravity in preparation for a NASA Research Announcement scheduled for release in late 1998 by the Microgravity Research Division at NASA Headquarters. The conference was aimed at materials science researchers from academia, industry, and government. A tour of the Marshall Space Flight Center microgravity research facilities was held on July 16, 1998. This volume is comprised of the research reports submitted by the principal investigators after the conference.

  6. NASA Microgravity Materials Science Conference

    NASA Technical Reports Server (NTRS)

    Szofran, Frank R. (Compiler); McCauley, D. (Compiler); Walker, C. (Compiler)

    1996-01-01

    The Microgravity Materials Science Conference was held June 10-11, 1996 at the Von Braun Civic Center in Huntsville, AL. It was organized by the Microgravity Materials Science Discipline Working Group, sponsored by the Microgravity Science and Applications Division at NASA Headquarters, and hosted by the NASA Marshall Space Flight Center and the Alliance for Microgravity Materials Science and Applications (AMMSA). It was the second NASA conference of this type in the microgravity materials science discipline. The microgravity science program sponsored approximately 80 investigations and 69 principal investigators in FY96, all of whom made oral or poster presentations at this conference. The conference's purpose was to inform the materials science community of research opportunities in reduced gravity in preparation for a NASA Research Announcement (NRA) scheduled for release in late 1996 by the Microgravity Science and Applications Division at NASA Headquarters. The conference was aimed at materials science researchers from academia, industry, and government. A tour of the MSFC microgravity research facilities was held on June 12, 1996. This volume is comprised of the research reports submitted by the principal investigators after the conference and presentations made by various NASA microgravity science managers.

  7. PREFACE: XXI Fluid Mechanics Conference

    NASA Astrophysics Data System (ADS)

    Szmyd, Janusz S.; Fornalik-Wajs, Elzbieta; Jaszczur, Marek

    2014-08-01

    This Conference Volume contains the papers presented at the 21st Fluid Mechanics Conference (XXI FMC) held at AGH - University of Science and Technology in Krakow, Poland, 15-18 June 2014, and accepted for Proceedings published in the Journal of Physics: Conference Series. The Fluid Mechanics Conferences have been taking place every two years since 1974, a total of forty years. The 21st Fluid Mechanics Conference (XXI FMC) is being organized under the auspices of the Polish Academy of Sciences, Committee of Mechanics. The goal of this conference is to provide a forum for the exposure and exchange of ideas, methods and results in fluid mechanics. Conference topics include, but are not limited to Aerodynamics, Atmospheric Science, Bio-Fluids, Combustion and Reacting Flows, Computational Fluid Dynamics, Experimental Fluid Mechanics, Flow Machinery, General Fluid Dynamics, Hydromechanics, Heat and Fluid Flow, Measurement Techniques, Micro- and Nano- Flow, Multi-Phase Flow, Non-Newtonian Fluids, Rotating and Stratified Flows, Turbulence. Within the general subjects of this conference, the Professor Janusz W. Elsner Competition for the best fluid mechanics paper presented during the Conference is organized. Authors holding a M.Sc. or a Ph.D. degree and who are not older than 35 years of age may enter the Competition. Authors with a Ph.D. degree must present individual papers; authors with a M.Sc. degree may present papers with their supervisor as coauthor, including original results of experimental, numerical or analytic research. Six state-of-the-art keynote papers were delivered by world leading experts. All contributed papers were peer reviewed. Recommendations were received from the International Scientific Committee, reviewers and the advisory board. Accordingly, of the 163 eligible extended abstracts submitted, after a review process by the International Scientific Committee, 137 papers were selected for presentation at the 21st Fluid Mechanics Conference, 68

  8. Special Conference on Tumor Immunology and Immunotherapy: A New Chapter.

    PubMed

    Byrne, Katelyn T; Vonderheide, Robert H; Jaffee, Elizabeth M; Armstrong, Todd D

    2015-05-12

    The overall objective of the fifth American Association for Cancer Research Special Conference, "Tumor Immunology and Immunotherapy: A New Chapter," organized by the Cancer Immunology Working Group, was to highlight multidisciplinary approaches of immunotherapy and mechanisms related to the ability of immunotherapy to fight established tumors. With the FDA approval of sipuleucel-T, ipilimumab (anti-CTLA-4; Bristol-Myers Squibb), and the two anti-PD-1 antibodies, pembrolizumab (formerly MK-3475 or lambrolizumab; Merck) and nivolumab (Bristol-Myers Squibb), immunotherapy has become a mainstream treatment option for some cancers. Many of the data presented at the conference and reviewed in this article showcase the progress made in determining the mechanistic reasons for the success of some treatments and the mechanisms associated with tolerance within the tumor microenvironment, both of which are potential targets for immunotherapy. In addition to combination and multimodal therapies, improvements in existing therapies will be needed to overcome the numerous ways that tumor-specific tolerance thwarts the immune system. This conference built upon the success of the 2012 conference and focused on seven progressing and/or emerging areas-new combination therapies, combination therapies and vaccine improvement, mechanisms of antibody therapy, factors in the tumor microenvironment affecting the immune response, the microbiomes effect on cancer and immunotherapy, metabolism in immunotherapy, and adoptive T-cell therapy. Cancer Immunol Res; 3(6); 1-8. ©2015 AACR.

  9. International conference on microbial enhancement of oil recovery

    SciTech Connect

    Donaldson, E.C.; Clark, J.B.

    1983-02-01

    An International Conference on Microbial Enhancement of Oil Recovery (MEOR) was held May 16-21, 1982 at Afton, Oklahoma. Its objective was to bring together microbiologists and engineers from around the world who are trying to develop methods for the application of microbial systems to the petroleum industry (32 scientists from 12 foreign countries attended). The conference generated 32 papers, nine poster presentations, and a short course on the fundamentals of petroleum reservoir geology. It showed that a new, more fundamental, approach is being taken in the search for ways to apply microbes to oil recovery. Great effort is being expended by microbiologists to understand the complex subsurface environment of a petroleum reservoir in relation to microbial metabolism; and by engineers to understand the fundamental activities of microbes before attempting to bring the two systems together. The conference was organized into seven formal sessions and three informal poster sessions that followed consecutively during the five days of the conference. A review of the papers revealed that they fall naturally into the following four divisions which are used in the organization of the proceedings: (1) microbes and their metabolites; (2) transport of bacteria in porous geological materials; (3) application to heavy oils; (4) MEOR field applications. All papers have been abstracted and indexed for the Energy Data Base.

  10. Special Conference on Tumor Immunology and Immunotherapy: A New Chapter

    PubMed Central

    Byrne, Katelyn T.; Vonderheide, Robert H.; Jaffee, Elizabeth M.; Armstrong, Todd D.

    2015-01-01

    The overall objective of the fifth American Association for Cancer Research Special Conference on “Tumor Immunology and Immunotherapy: A New Chapter” organized by the Cancer Immunology Working Group was to highlight multidisciplinary approaches of immunotherapy and mechanisms related to the ability of immunotherapy to fight established tumors. With the FDA approval of sipuleucel-T, ipilimumab (anti-CTLA4; Bristol-Myers Squibb [BMS]), and the two anti-PD-1 antibodies, pembrolizumab (formerly MK-3475 or lambrolizumab; Merck) and nivolumab (BMS), immunotherapy has become a mainstream treatment option for some cancer. Many of the data presented at the conference and reviewed in this article showcase the progress made in determining the mechanistic reasons for the success of some treatments and the mechanisms associated with tolerance within the tumor microenvironment, both of which are potential targets for immunotherapy. In addition to combination and multimodal therapies, improvements in existing therapies will be needed to overcome the numerous ways that tumor-specific tolerance thwarts the immune system. This conference built upon the success of the 2012 conference, and focused on seven progressing and/or emerging areas that include: New combination therapies; Combination therapies and vaccine Improvement; Mechanisms of antibody therapy; Factors in the tumor microenvironment affecting the immune response; The microbiomes effect on cancer and immunotherapy; Metabolism in immunotherapy; and Adoptive T-cell therapy. PMID:25968457

  11. EDITORIAL: International MEMS Conference 2006

    NASA Astrophysics Data System (ADS)

    Tay, Francis E. H.; Jianmin, Miao; Iliescu, Ciprian

    2006-04-01

    The International MEMS conference (iMEMS2006) organized by the Institute of Bioengineering and Nanotechnology and Nanyang Technological University aims to provide a platform for academicians, professionals and industrialists in various related fields from all over the world to share and learn from each other. Of great interest is the incorporation of the theme of life sciences application using MEMS. It is the desire of this conference to initiate collaboration and form network of cooperation. This has continued to be the objective of iMEMS since its inception in 1997. The technological advance of MEMS over the past few decades has been truly exciting in terms of development and applications. In order to participate in this rapid development, a conference involving delegates from within the MEMS community and outside the community is very meaningful and timely. With the receipt of over 200 articles, delegates related to MEMS field from all over the world will share their perspectives on topics such as MEMS/MST Design, MEMS Teaching and Education, MEMS/MST Packaging, MEMS/MST Fabrication, Microsystems Applications, System Integration, Wearable Devices, MEMSWear and BioMEMS. Invited speakers and delegates from outside the field have also been involved to provide challenges, especially in the life sciences field, for the MEMS community to potentially address. The proceedings of the conference will be published as an issue in the online Journal of Physics: Conference Series and this can reach a wider audience and will facilitate the reference and citation of the work presented in the conference. We wish to express our deep gratitude to the International Scientific Committee members and the organizing committee members for contributing to the success of this conference. We would like to thank all the delegates, speakers and sponsors from all over the world for presenting and sharing their perspectives on topics related to MEMS and the challenges that MEMS can

  12. International Conference on the Cell and Molecular Biology of Chlamydomonas

    SciTech Connect

    Dr. Stephen Miller

    2010-06-10

    The 2010 Conference on the Cell and Molecular Biology of Chlamydomonas was held June 6-10 near Boston, MA, and attracted a record 273 participants, 146 from US labs, 10 from Canada, and the remainder from 18 other countries. The single-celled algal protist Chlamydomonas is a key research organism for many investigators, including those who study photosynthesis, cell motility, adaptation to environmental stresses, the evolution of multicellularity, and the production of biofuels. Chlamydomonas researchers gather every two years at a research conference to exchange methods, develop collaborative efforts, disseminate recent findings, and plan large-scale studies to improve the usefulness of this unique research organism. This conference provides the only opportunity for Chlamydomonas scientists who work on different research problems to meet face to face, and greatly speeds progress in their respective fields. An important function of these Chlamydomonas conferences is to promote and showcase the work of younger scientists, and to attract new investigators into the Chlamydomonas community. DOE award SC0004085 was used to offset the travel and registration costs for 18 young investigators, 9 of whom were women, including one African American. Most of these scientists would not have been able to attend the conference without DOE support. A total of 208 research presentations were made at the meeting, 80 talks (63 presented by students, postdocs, and pre-tenured faculty) and 128 posters. Cell motility and biofuels/metabolism were the best-represented research areas, with a total of 77 presentations. This fact underscores the growing importance of Chlamydomonas as a research and production tool in the rapidly expanding world of biofuels research. A total of 28 talks and posters were presented on the topics of photosynthesis and stress responses, which were among the next best-represented research areas. As at several recent Chlamydomonas meetings, important advances were

  13. ASM Conference on Prokaryotic Development

    SciTech Connect

    Kaplan, H. B.

    2005-07-13

    Support was provided by DOE for the 2nd ASM Conference on Prokaryotic Development. The final conference program and abstracts book is attached. The conference presentations are organized around topics that are central to the current research areas in prokaryotic development. The program starts with topics that involve relatively simple models systems and ends with systems that are more complex. The topics are: i) the cell cycle, ii) the cytoskeleton, iii) morphogenesis, iv) developmental transcription, v) signaling, vi) multicellularity, and vii) developmental diversity and symbiosis. The best-studied prokaryotic development model systems will be highlighted at the conference through research presentations by leaders in the field. Many of these systems are also model systems of relevance to the DOE mission including carbon sequestration (Bradyrizobium, Synechococcus), energy production (Anabaena, Rhodobacter) and bioremediation (Caulobacter, Mesorhizobium). In addition, many of the highlighted organisms have important practical applications; the actinomycetes and myxobacteria produce antimicrobials that are of commercial interest. It is certain that the cutting-edge science presented at the conference will be applicable to the large group of bacteria relevant to the DOE mission.

  14. Conference Comments by the Editors

    NASA Astrophysics Data System (ADS)

    Novotny, Rainer; Nikl, Martin; Williams, Richard T.; Auffray, Etiennette; Dorenbos, Pieter; Dujardin, Christophe; era, Miroslav Ku c.˘; Mihóková, Eva; Wojtowicz, Andrzej J.

    2012-10-01

    The SCINT series of conferences on Inorganic Scintillators and their Applications has provided, beginning in 1992, a regular platform for researchers from all over the world working in this field. This conference merges the aspects of basic science with application-related issues in the field of inorganic scintillators and phosphors and provides unique opportunities for both scientists and engineers to exchange their new results and ideas. Previous SCINT conferences were held first in Chamonix in 1992 and then in San Francisco, Delft, Shanghai, Moscow, Chamonix, Valencia, Alushta, Winston- Salem, and Jeju Island in Korea in 2009. The most recent, the 11th International Conference on Inorganic Scintillators and their Applications (SCINT 2011), was held at the Science Campus of Justus Liebig University, Giessen, Germany, September 11¿16, 2011. There were a total 187 scientific contributions, 82 oral presentations, 19 invited talks, and 105 poster exhibitions presented by 235 participants from 24 different countries. For the first time, a pre-conference tutorial was organized, which covered the basic physics of scintillation mechanisms as well as the wide field of applications. The purpose was mainly to educate students and newcomers in the field. This special issue of the IEEE TRANSACTIONS ON NUCLEAR SCIENCE comprises the refereed proceedings of SCINT 2011, containing 61 papers on the research presentations.

  15. World Food Conference: Issues and Preparation for Conference,

    DTIC Science & Technology

    1974-01-17

    AD-AO&I 2-95 DEPARTMENT OF STATE WASHINGTON 0 C OFFICE OF EkeTERNA-TP F/6 2/1! I WORLD FOOD CONFERENCE: ISSUES AND PREPARtATION FOR CONFERENCE. (U) M...suppanwlyd to ur nt wodete finslueis l gisvclain 3) What l role a tFod Aidurassumeainthe hangngwolufodstutin 4 ) What roe thlcatoionasum of te ihgng...odoupld demd foruatthe 4 )Waitral dhevemlicopmn policiens an strategpy f d themn orld’s developing countries? The present report considers current

  16. Nutrition, Metabolic Disorders and Lifestyle of Aircrew

    DTIC Science & Technology

    1993-01-01

    SUR SEINE FRANCE Paper Reprinted from AGARD Conference Proceedings 533 Nutrition , Metabolic Disorders and Lifestyle of Aircrew (Les Desordres...Ed.), "Psychobiology of As discussed above, caffeine, when it is consumed in doses Human Eating and Nutritional Behaviour", Chichester, found in many...aircrew members. 8. Graham, D.M.. "Caffeine -- Its Identity, Dietary Sources, Intake and Biological Effects", Nutrition Reviews, Therefore, it is not

  17. Metabolic Analysis

    NASA Astrophysics Data System (ADS)

    Tolstikov, Vladimir V.

    Analysis of the metabolome with coverage of all of the possibly detectable components in the sample, rather than analysis of each individual metabolite at a given time, can be accomplished by metabolic analysis. Targeted and/or nontargeted approaches are applied as needed for particular experiments. Monitoring hundreds or more metabolites at a given time requires high-throughput and high-end techniques that enable screening for relative changes in, rather than absolute concentrations of, compounds within a wide dynamic range. Most of the analytical techniques useful for these purposes use GC or HPLC/UPLC separation modules coupled to a fast and accurate mass spectrometer. GC separations require chemical modification (derivatization) before analysis, and work efficiently for the small molecules. HPLC separations are better suited for the analysis of labile and nonvolatile polar and nonpolar compounds in their native form. Direct infusion and NMR-based techniques are mostly used for fingerprinting and snap phenotyping, where applicable. Discovery and validation of metabolic biomarkers are exciting and promising opportunities offered by metabolic analysis applied to biological and biomedical experiments. We have demonstrated that GC-TOF-MS, HPLC/UPLC-RP-MS and HILIC-LC-MS techniques used for metabolic analysis offer sufficient metabolome mapping providing researchers with confident data for subsequent multivariate analysis and data mining.

  18. Metabolic cardiomyopathies

    PubMed Central

    Guertl, Barbara; Noehammer, Christa; Hoefler, Gerald

    2000-01-01

    The energy needed by cardiac muscle to maintain proper function is supplied by adenosine Ariphosphate primarily (ATP) production through breakdown of fatty acids. Metabolic cardiomyopathies can be caused by disturbances in metabolism, for example diabetes mellitus, hypertrophy and heart failure or alcoholic cardiomyopathy. Deficiency in enzymes of the mitochondrial β-oxidation show a varying degree of cardiac manifestation. Aberrations of mitochondrial DNA lead to a wide variety of cardiac disorders, without any obvious correlation between genotype and phenotype. A completely different pathogenetic model comprises cardiac manifestation of systemic metabolic diseases caused by deficiencies of various enzymes in a variety of metabolic pathways. Examples of these disorders are glycogen storage diseases (e.g. glycogenosis type II and III), lysosomal storage diseases (e.g. Niemann-Pick disease, Gaucher disease, I-cell disease, various types of mucopolysaccharidoses, GM1 gangliosidosis, galactosialidosis, carbohydrate–deficient glycoprotein syndromes and Sandhoff's disease). There are some systemic diseases which can also affect the heart, for example triosephosphate isomerase deficiency, hereditary haemochromatosis, CD 36 defect or propionic acidaemia. PMID:11298185

  19. Inaugural AGU Science Policy Conference

    NASA Astrophysics Data System (ADS)

    Uhlenbrock, Kristan

    2012-01-01

    AGU will present its inaugural Science Policy Conference, 30 April to 3 May 2012, at the Ronald Reagan Building and International Trade Center, located in downtown Washington, D. C. This conference will bring together leading scientists, policy makers, industry professionals, press, and other stakeholders to discuss natural hazards, natural resources, oceans, and Arctic science and the role these sciences play in serving communities. To bridge the science and policy fields, AGU plans to host this conference every 2 years and focus on the applications of Earth and space sciences to serve local and national communities. "Our nation faces a myriad of challenges such as the sustainability of our natural resources, current and future energy needs, and the ability to mitigate and adapt to natural and manmade hazards," said Michael McPhaden, president of AGU. "It is essential that policies to address these challenges be built on a solid foundation of credible scientific knowledge."

  20. Message from the Conference Chairs

    NASA Astrophysics Data System (ADS)

    Krishna, Sanjay; Perera, Unil

    2015-05-01

    We were very excited to host the 8th International Workshop on Quantum Structure Infrared Photodetectors (QSIP 2014), in picturesque Santa Fe, New Mexico from June 29th-July 3rd, 2014. This followed successful QSIP conferences at Dana Point (2000), Torino (2002), Kananaskis (2004), Kandy (2006), Yosimite (2009), Istanbul (2010) and Corsica (2012). The QSIP workshop is a high level scientific conference that aims to bring together scientists, engineers, industrial organizations, students and users in order to discuss recent advances, and to share the "State of the Art" in this field. QSIP conferences provide an international forum for attendees to present and discuss progress in infrared device physics and modeling, materials growth and processing issues, focal plane array development and characterization.

  1. 9th Caribbean Geological Conference

    NASA Astrophysics Data System (ADS)

    Draper, Gren

    The ninth in a series of Caribbean Geological Conferences, which are held every 3 or 4 years, took place in Santo Domingo, capital of the Dominican Republic, from the 15th to 26th of August 1980. The conference, which was sponsored by the government of the Dominican Republic and the Universidad Catolica Madre y Maestra, was preceded by 2 days of field trips and was opened by President Antonio Guzman on the evening of the 17th of August. Generous support was provided by Alcoa Exploration Co., Falconbridge Dominicana, and Rosario Dominicana.Geologists and geophysicists from 25 countries presented about 130 papers on a wide variety of topics ranging from geophysics to paleontology. While the whole Caribbean area was discussed, there was special emphasis on the northern Caribbean and Hispaniola, as befitted the site of the conference. The contribution of workers from the Dirección General de Mineriá was particularly notable.

  2. 2002 Microgravity Materials Science Conference

    NASA Technical Reports Server (NTRS)

    Gillies, Donald (Editor); Ramachandran, Narayanan (Editor); Murphy, Karen (Editor); McCauley, Dannah (Editor); Bennett, Nancy (Editor)

    2003-01-01

    The 2002 Microgravity Materials Science Conference was held June 25-26, 2002, at the Von Braun Center, Huntsville, Alabama. Organized by the Microgravity Materials Science Discipline Working Group, sponsored by the Physical Sciences Research Division, NASA Headquarters, and hosted by NASA Marshall Space Flight Center and member institutions under the Cooperative Research in Biology and Materials Science (CORBAMS) agreement, the conference provided a forum to review the current research and activities in materials science, discuss the envisioned long-term goals, highlight new crosscutting research areas of particular interest to the Physical Sciences Research Division, and inform the materials science community of research opportunities in reduced gravity. An abstracts book was published and distributed at the conference to the approximately 240 people attending, who represented industry, academia, and other NASA Centers. This CD-ROM proceedings is comprised of the research reports submitted by the Principal Investigators in the Microgravity Materials Science program.

  3. 17th International Conference on Arabidopsis Research

    SciTech Connect

    Bender, Judith

    2006-07-02

    The 17th International Conference on Arabidopsis Research was held at the University of Madison, Wisconsin from June 27- July 2, 2006. ICAR-2006 included approximately 625 scientists from across the world. The scientific program was of excellent quality featuring 73 talks, including 30 from invited speakers. There were also 6 community-organized workshops (facilitated by conference staff) featuring additional talks on topics including ‘Submitting data to long-term repositories,’ ‘TAIR introductory workshop,’ ‘Web services and demonstration,’ ‘Public engagement: broadening the impact of your research,’ ‘Systems biology approaches to analysis of metabolic and regulatory networks of Arabidopsis,’ and ‘Mechanotransduction in Arabidopsis.’ Approximately 440 posters were presented in general topic areas including, among others, Development, Modeling/Other Systems, Energy, Environment, and Genetic/Epigenetic mechanisms. Graduate students, postdoctoral researchers, junior faculty, and underrepresented minorities made up a significant portion of the oral presentations thereby promoting the training of young scientists and facilitating important career development opportunities for speakers. Several poster sessions provided an opportunity for younger participants to freely meet with more established scientists. The North American Arabidopsis Steering Committee (NAASC) continued its outreach effort and again sponsored two special luncheons to encourage personal and professional development of young scientists and also underrepresented minorities. The ‘Emerging Scientists Luncheon’ featured 10 graduate students selected on the basis of scientific excellence of their submitted research abstracts. The ‘Minority Funding Luncheon,’ featured 8 awardees selected by the NAASC through a widely-publicized application process. This luncheon was established specifically to provide an opportunity for underrepresented minorities, and/or scientists from

  4. 2003 Archaea: Ecology, Metabolism and Molecular Biology

    SciTech Connect

    Richard F. Shand

    2004-09-21

    The Gordon Research Conference (GRC) on 2003 Archaea: Ecology, Metabolism and Molecular Biology was held at Proctor Academy, Andover, NH from August 3-8, 2003. The Conference was well-attended with 150 participants (attendees list attached). The attendees represented the spectrum of endeavor in this field coming from academia, industry, and government laboratories, both U.S. and foreign scientists, senior researchers, young investigators, and students. In designing the formal speakers program, emphasis was placed on current unpublished research and discussion of the future target areas in this field. There was a conscious effort to stimulate lively discussion about the key issues in the field today. Time for formal presentations was limited in the interest of group discussions. In order that more scientists could communicate their most recent results, poster presentation time was scheduled. Attached is a copy of the formal schedule and speaker program and the poster program. In addition to these formal interactions, ''free time'' was scheduled to allow informal discussions. Such discussions are fostering new collaborations and joint efforts in the field. I want to personally thank you for your support of this Conference. As you know, in the interest of promoting the presentation of unpublished and frontier-breaking research, Gordon Research Conferences does not permit publication of meeting proceedings. If you wish any further details, please feel free to contact me. Thank you, Dr. Richard F. Shand, 2003 Conference Chair.

  5. First Stars III Conference Summary

    NASA Astrophysics Data System (ADS)

    O'Shea, B. W.; McKee, C. F.; Heger, A.; Abel, T.

    2008-03-01

    The understanding of the formation, life, and death of Population III stars, as well as the impact that these objects had on later generations of structure formation, is one of the foremost issues in modern cosmological research and has been an active area of research during the past several years. We summarize the results presented at "First Stars III," a conference sponsored by Los Alamos National Laboratory, the Kavli Institute for Particle Astrophysics and Cosmology, and the Joint Institute for Nuclear Astrophysics. This conference, the third in a series, took place in July 2007 at the La Fonda Hotel in Santa Fe, New Mexico, U.S.A.

  6. Ethnic minority energy conference: report

    SciTech Connect

    Not Available

    1984-01-01

    The report of a 1977 energy conference sponsored by the National Association for the Advancement of Colored People summarizes the basic concern that US energy policy was not addressing the importance of full employment or the impact of rising energy costs on the poor. Conference speakers spoke of the social and economic changes that are needed if minorities are to participate in the economics of the technological age. These include better educational opportunities and cooperation between civil rights groups and energy planners. Other topics were venture opportunities for minorities in energy-related fields and opportunities for minority advocacy and energy efficiency actions.

  7. Mechanics of Textile Composites Conference

    NASA Technical Reports Server (NTRS)

    Poe, Clarence C. (Editor); Harris, Charles E. (Editor)

    1995-01-01

    This document is a compilation of papers presented at the Mechanics of Textile Composites Conference in Hampton, Virginia, December 6-8, 1994. This conference was the culmination of a 3-year program that was initiated by NASA late in 1990 to develop mechanics of textile composites in support of the NASA Advance Composites Technology Program (ACT). The goal of the program was to develop mathematical models of textile preform materials and test methods to facilitate structural analysis and design. Participants in the program were from NASA, academia, and industry.

  8. Chapman Conference on Rainfall Fields

    NASA Astrophysics Data System (ADS)

    Gupta, V. K.

    The Chapman Conference on Rainfall Fields, sponsored by AGU, was the first of its kind; it was devoted to strengthening scientific interaction between the North American and Latin American geophysics communities. It was hosted by Universidad Simon Bolivar and Instituto Internacional de Estudios Avanzados, in Caracas, Venezuela, during March 24-27, 1986. A total of 36 scientists from Latin America, the United States, Canada, and Europe participated. The conference, which was convened by I. Rodriguez-Iturbe (Universidad Simon Bolivar) and V. K. Gupta (University of Mississippi, University), brought together hydrologists, meteorologists, and mathematicians/statisticians in the name of enhancing an interdisciplinary focus on rainfall research.

  9. Mechanics of Textile Composites Conference

    SciTech Connect

    Poe, C.C.; Harris, C.E.

    1995-10-01

    This document is a compilation of papers presented at the Mechanics of Textile Composites Conference in Hampton, Virginia, December 6-8, 1994. This conference was the culmination of a 3-year program that was initiated by NASA late in 1990 to develop mechanics of textile composites in support of the NASA Advance Composites Technology Program (ACT). The goal of the program was to develop mathematical models of textile preform materials and test methods to facilitate structural analysis and design. Participants in the program were from NASA, academia, and industry. Separate abstracts were prepared for articles from this document.

  10. Nineteenth annual actinide separations conference: Conference program and abstracts

    SciTech Connect

    Bronson, M.

    1995-12-31

    This report contains the abstracts from the conference presentations. Sessions were divided into the following topics: Waste treatment; Spent fuel treatment; Issues and responses to Defense Nuclear Facility Safety Board 94-1; Pyrochemical technologies; Disposition technologies; and Aqueous separation technologies.

  11. Inter Association Child Care Conference. Conference Proceedings 1979.

    ERIC Educational Resources Information Center

    Austin, David, Ed.

    This publication of the proceedings of the Inter Association Child Care Conference includes a debate for and against professionalization in the field of child care. A section on meeting the treatment needs of children through educational preparation of child care practitioners discusses background factors, levels of education for practitioners,…

  12. 47 CFR 1.248 - Prehearing conferences; hearing conferences.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... submitting written appearances pursuant to § 1.221(h) or within such shorter or longer period as the... conference shall be held no later than 10 calendar days after the deadline for submitting written appearances... § 1.246), and the possibility of stipulating with respect to facts; (3) The procedure at the hearing...

  13. Conference Proceedings: Health Manpower Planning Conference. May, 1971.

    ERIC Educational Resources Information Center

    Hospital Educational and Research Foundation of Pennsylvania, Camp Hill.

    A two-day Health Manpower Planning Conference was held at State College, Pennsylvania, in 1971. The speakers represented a variety of organizations with responsibility for aspects of manpower planning and others not normally involved in planning. Program content was structured in such a way as to broaden the context within which manpower issues…

  14. Inter Association Child Care Conference. Conference Proceedings 1979.

    ERIC Educational Resources Information Center

    Austin, David, Ed.

    This publication of the proceedings of the Inter Association Child Care Conference includes a debate for and against professionalization in the field of child care. A section on meeting the treatment needs of children through educational preparation of child care practitioners discusses background factors, levels of education for practitioners,…

  15. [Homocysteine metabolism].

    PubMed

    Hashimoto, Takao; Shinohara, Yoshihiko; Hasegawa, Hiroshi

    2007-10-01

    Homocysteine, a sulfur amino acid, is an intermediate metabolite of methionine. In 1969, McCully reported autopsy evidence of extensive arterial thrombosis and atherosclerosis in children with elevated plasma homocysteine concentrations and homocystinuria. On the basis of this observation, he proposed that elevated plasma homocysteine (hyperhomocysteinemia) can cause atherosclerotic vascular disease. Hyperhomocysteinemia is now well established as an independent risk factor for atherosclerotic vascular disease. Mild hyperhomocysteinemia is quite prevalent in the general population. It can be caused by genetic defects in the enzymes involved in homocysteine metabolism or nutritional deficiencies in vitamin cofactors, certain medications or renal disease. An increase of 5 micromol per liter in the plasma homocysteine concentration raises the risk of coronary artery disease by as much as an increase of 20 mg per deciliter in the cholesterol concentration. In this article, we review the biochemical, experimental and clinical studies on hyperhomocysteinemia, with emphasis on the metabolism and pharmacokinetics of homocysteine.

  16. 38 CFR 59.123 - Conference.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... recommend that a conference (such as a design development conference) be held in VA Central Office in Washington, DC, to provide an opportunity for the State and its architects to discuss requirements for...

  17. 48 CFR 242.503 - Postaward conferences.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Postaward conferences. 242.503 Section 242.503 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM... 242.503 Postaward conferences....

  18. 48 CFR 242.503 - Postaward conferences.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Postaward conferences. 242.503 Section 242.503 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM... 242.503 Postaward conferences....

  19. 7 CFR 1.167 - Conference.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... that conducting the conference by audio-visual telecommunication: (i) Is necessary to prevent prejudice... in the conference: (i) Is necessary to prevent prejudice to a party; (ii) Is necessary because of...

  20. 1995 International Sherwood Fusion Theory Conference

    SciTech Connect

    1995-07-01

    This book is a guide to the 1995 International Sherwood Fusion Theory Conference. It consists largely of abstracts of the oral and poster presentations that were to be made, and gives some general information about the conference and its schedule.

  1. A Good Day Out? Conferences and Learning.

    ERIC Educational Resources Information Center

    Richards, Mary

    1993-01-01

    Attendance at conferences provides opportunities for developing listening, notetaking, and questioning skills as well as confidence and self-esteem. Planning conferences provides other experiential learning through such roles as entrepreneur, administrator, troubleshooter, and organizer. (SK)

  2. Conferences in Context: Status, Communication, and Evaluation

    ERIC Educational Resources Information Center

    Wagner, L. Wesley; Brinkerhoff, Merlin

    1975-01-01

    The relationship between managers and three variables are examined: time commitments of managers to staff conferences, status or rank of managers, and the quality of communicative exchange in conference settings. (Author/DEP)

  3. 15 CFR 25.19 - Prehearing conferences.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...) Upon the motion of any party, the ALJ shall schedule at least one prehearing conference at a reasonable time in advance of the hearing. (c) The ALJ may use prehearing conferences to discuss the following:...

  4. 45 CFR 79.19 - Prehearing conferences.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... the motion of any party, the ALJ shall schedule at least one prehearing conference at a reasonable time in advance of the hearing. (c) The ALJ may use prehearing conferences to discuss the following:...

  5. Technology Utilization Conference Series, volume 1

    NASA Technical Reports Server (NTRS)

    1975-01-01

    The design, development, and results of a series of technology utilization conferences are presented. The conference series represents the development of a viable and successful means of encouraging the transfer of technology to the minority business community.

  6. Metabolic Downregulation

    PubMed Central

    Yenari, Midori; Kitagawa, Kazuo; Lyden, Patrick; Perez-Pinzon, Miguel

    2008-01-01

    Background and Purpose The search for effective neuroprotectants remains frustrating, particularly with regard to specific pharmaceuticals. However, laboratory studies have consistently shown remarkable neuroprotection with 2 nonpharmacological strategies—therapeutic hypothermia and ischemic preconditioning. Recent studies have shown that the mechanism of protection underlying both of these treatments is correlated to downregulation of cellular and tissue metabolism. Thus, understanding the mechanisms underlying such robust protective effects could lead to appropriate translation at the clinical level. In fact, hypothermia is already being used at many centers to improve neurological outcome from cardiac arrest. Methods A systematic review of both topics is presented in terms of underlying pathophysiological mechanisms and application at the clinical level. Results Although the mechanisms of protection for both therapeutic strategies are multifold, both share features of downregulating metabolism. Both therapeutic strategies are robust neuroprotectants, but translating them to the clinical arena is challenging, though not impossible, and clinical studies have shown or suggest benefits of both treatments. Conclusions The strategy of metabolic downregulation should be further explored to identify effective neuroprotectants that can be easily applied clinically. PMID:18658035

  7. What is Metabolic Syndrome?

    MedlinePlus

    ... from the NHLBI on Twitter. What Is Metabolic Syndrome? Metabolic syndrome is the name for a group of ... that may play a role in causing metabolic syndrome. Outlook Metabolic syndrome is becoming more common due to a ...

  8. 48 CFR 42.505 - Postaward subcontractor conferences.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... subcontractor conferences. (a) The prime contractor is generally responsible for conducting postaward conferences with subcontractors. However, the prime contractor may invite Government representatives to a conference with subcontractors, or the Government may request that the prime contractor initiate a conference...

  9. 48 CFR 42.505 - Postaward subcontractor conferences.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... subcontractor conferences. (a) The prime contractor is generally responsible for conducting postaward conferences with subcontractors. However, the prime contractor may invite Government representatives to a conference with subcontractors, or the Government may request that the prime contractor initiate a conference...

  10. Genome Sequencing and Analysis Conference IV

    SciTech Connect

    Not Available

    1993-12-31

    J. Craig Venter and C. Thomas Caskey co-chaired Genome Sequencing and Analysis Conference IV held at Hilton Head, South Carolina from September 26--30, 1992. Venter opened the conference by noting that approximately 400 researchers from 16 nations were present four times as many participants as at Genome Sequencing Conference I in 1989. Venter also introduced the Data Fair, a new component of the conference allowing exchange and on-site computer analysis of unpublished sequence data.

  11. Apollo 11 Lunar Science Conference

    ERIC Educational Resources Information Center

    Cochran, Wendell

    1970-01-01

    Report of a conference called to discuss the findings of 142 scientists from their investigations of samples of lunar rock and soil brought back by the Apollo 11 mission. Significant findings reported include the age and composition of the lunar samples, and the absence of water and organic matter. Much discussed was the origin and structure of…

  12. Thirteenth International Laser Radar Conference

    NASA Technical Reports Server (NTRS)

    1986-01-01

    One hundred fifteen papers were presented in both oral and poster sessions. The topics of the conference sessions were: spaceborne lidar applications; extinction/visibility; differential absorption lidar; winds and tropospheric studies; middle atmosphere; clouds and multiple scattering; pollution studies; and new systems.

  13. Space Station Freedom Utilization Conference

    NASA Technical Reports Server (NTRS)

    1992-01-01

    The topics addressed in Space Station Freedom Utilization Conference are: (1) space station freedom overview and research capabilities; (2) space station freedom research plans and opportunities; (3) life sciences research on space station freedom; (4) technology research on space station freedom; (5) microgravity research and biotechnology on space station freedom; and (6) closing plenary.

  14. Commercial Human Spaceflight Press Conference

    NASA Image and Video Library

    2010-02-02

    NASA Administrator Charles Bolden speaks during a press conference, Tuesday, Feb. 2, 2010, at the National Press Club in Washington, where it was announced that NASA has awarded $50 million through funded agreements to further the commercial sector's capability to support transport of crew to and from low Earth orbit. Photo Credit: (NASA/Bill Ingalls)

  15. Commercial Human Spaceflight Press Conference

    NASA Image and Video Library

    2010-02-02

    NASA Administrator Charles Bolden's reflection is seen in a TV monitor during a press conference, Tuesday, Feb. 2, 2010, at the National Press Club in Washington, where it was announced that NASA has awarded $50 million through funded agreements to further the commercial sector's capability to support transport of crew to and from low Earth orbit. Photo Credit: (NASA/Bill Ingalls)

  16. Commercial Human Spaceflight Press Conference

    NASA Image and Video Library

    2010-02-02

    Mike Gass, President and Chief Executive, United Launch Alliance is seen during a press conference, Tuesday, Feb. 2, 2010, at the National Press Club in Washington, where it was announced that NASA has awarded $50 million through funded agreements to further the commercial sector's capability to support transport of crew to and from low Earth orbit. Photo Credit: (NASA/Bill Ingalls)

  17. Commercial Human Spaceflight Press Conference

    NASA Image and Video Library

    2010-02-02

    Jane Poynter, President and Chair, Paragon Space Development Corp. is seen during a press conference, Tuesday, Feb. 2, 2010, at the National Press Club in Washington, where it was announced that NASA has awarded $50 million through funded agreements to further the commercial sector's capability to support transport of crew to and from low Earth orbit. Photo Credit: (NASA/Bill Ingalls)

  18. Commercial Human Spaceflight Press Conference

    NASA Image and Video Library

    2010-02-02

    Robert Millman of Blue Origin is seen during a press conference, Tuesday, Feb. 2, 2010, at the National Press Club in Washington, where it was announced that NASA has awarded $50 million through funded agreements to further the commercial sector's capability to support transport of crew to and from low Earth orbit. Photo Credit: (NASA/Bill Ingalls)

  19. Commercial Human Spaceflight Press Conference

    NASA Image and Video Library

    2010-02-02

    Brewster Shaw, VP and General Manager, NASA Systems, Boeing is seen during a press conference, Tuesday, Feb. 2, 2010, at the National Press Club in Washington, where it was announced that NASA has awarded $50 million through funded agreements to further the commercial sector's capability to support transport of crew to and from low Earth orbit. Photo Credit: (NASA/Bill Ingalls)

  20. Expedition 21 Prelaunch Press Conference

    NASA Image and Video Library

    2009-09-28

    Spaceflight Participant Guy Laliberté, left, and Expedition 21 Flight Engineer Maxim Suraev, talk to each other at the start of the press conference, Tuesday, Sept. 29, 2009 at the Cosmonaut Hotel in Baikonur, Kazakhstan. Photo Credit: (NASA/Bill Ingalls)

  1. Expedition 21 Prelaunch Press Conference

    NASA Image and Video Library

    2009-09-28

    Spaceflight Participant Guy Laliberté, left, Expedition 21 Flight Engineer Maxim Suraev, center, and Expedition 21 Flight Engineer Jeffrey N. Williams wave hello and point to members of their families at the start of the press conference, Tuesday, Sept. 29, 2009 at the Cosmonaut Hotel in Baikonur, Kazakhstan. Photo Credit: (NASA/Bill Ingalls)

  2. Expedition 21 Prelaunch Press Conference

    NASA Image and Video Library

    2009-09-28

    Spaceflight Participant Guy Laliberté, left, Expedition 21 Flight Engineer Maxim Suraev, center, and Expedition 21 Flight Engineer Jeffrey N. Williams pose for a group photograph at the end of the press conference, Tuesday, Sept. 29, 2009 at the Cosmonaut Hotel in Baikonur, Kazakhstan. Photo Credit: (NASA/Bill Ingalls)

  3. Expedition 21 Prelaunch Press Conference

    NASA Image and Video Library

    2009-09-28

    Backup Spaceflight Participant Barbara Barrett, left, backup Expedition 21 Commander Aleksandr Skvortsov, center, and backup Expedition 21 Flight Engineer Shannon Walker are seen during a press conference, Tuesday, Sept. 29, 2009 at the Cosmonaut Hotel in Baikonur, Kazakhstan. Photo Credit: (NASA/Bill Ingalls)

  4. NOLPE Conference Proceedings, November 1968.

    ERIC Educational Resources Information Center

    National Organization on Legal Problems of Education, Topeka, KS.

    This booklet contains the texts of speeches given at the 1968 National Organization on Legal Problems of Education conference on school law. The topics covered in the speeches include student rights, dress codes, defacto segregation, education and religious freedom, doctoral dissertations in school law, master contracts, and teacher strikes. (JF)

  5. Conference comments by the Editors

    NASA Astrophysics Data System (ADS)

    Zhao, Jing-Tai; Nikl, Martin; Williams, Richard T.; Auffray, Etiennette; Bizarri, Greg; Gu, Mu; Nagirnyi, Vitali; Pejchal, Jan; Sidletskiy, Oleg; Vedda, Anna

    2014-02-01

    The international community of researchers on fundamentals, development, and applications of inorganic scintillator materials has found the biennial meetings of the SCINT series to be an excellent chance to exchange data and ideas. These can range from very basic physical concepts and atomistic mechanisms in the materials under study up to truly application-minded tasks and problems defined by the modern needs for radiation detection, imaging, and spectroscopy of many kinds. The 12th International Conference on Inorganic Scintillators and their Applications (SCINT 2013) was organized by the Shanghai Institute of Ceramics, Chinese Academy of Sciences, in Shanghai, April 15-19, 2013. There were in total 180 scientific contributions, 85 oral presentations, 17 invited talks, and 95 poster exhibitions presented by 147 participants from 18 different countries. This special issue of the IEEE TRANSACTIONS ON NUCLEAR SCIENCE comprises the selected and refereed original works based on the SCINT 2013 presentations, altogether 51 papers. The conference was technically and financially co-sponsored by the Chinese Academy of Sciences, and Nuclear and Plasma Sciences Society (IEEE). The SCINT 2013 conference organizers acknowledge with deep thanks also the sponsorship and support of seven domestic and foreign industrial companies participating in the conference exhibition.

  6. Computer Conferences: Success or Failure?

    ERIC Educational Resources Information Center

    Phillips, Amy Friedman

    This examination of the aspects of computers and computer conferencing that can lead to their successful design and utilization focuses on task-related functions and emotional interactions in human communication and human-computer interactions. Such aspects of computer conferences as procedures, problems, advantages, and suggestions for future…

  7. SLA's Conference Wrap-Up.

    ERIC Educational Resources Information Center

    Shepherd, Susan J., Comp.

    1987-01-01

    Encapsulates a wrap-up session on technical programs presented at the Special Libraries Association's June 1987 conference, including presentations in the areas of information technology, management, education, and international issues. Ethics, value, leadership, international issues, image, and risk are identified as major themes of the…

  8. What Good Are Conferences, Anyway?

    ERIC Educational Resources Information Center

    Pietro, David C.

    1996-01-01

    According to Frederick Herzberg's studies of employee motivation, humans are driven by motivating factors that allow them to grow psychologically and hygiene factors that help them meet physical needs. Good education conferences can enhance both factors by helping principals refocus their energies, exchange ideas with trusted colleagues, and view…

  9. 2001 MAPLD International Conference Proceedings

    NASA Technical Reports Server (NTRS)

    2002-01-01

    This CD contains the proceedings from the '2001 MAPLD International Conference', held on 11-13 September 2001 at Johns Hopkins University. Sessions included the following: (1) Applications: Military and Aerospace; (2) Design 1: Processors, Logic, and Programmable Devices; (3) Reliability: Devices and The Effects of the Radiation Environment; (4) Design 2: Systems; and (5) Design 3: Fault Tolerance.

  10. What Good Are Conferences, Anyway?

    ERIC Educational Resources Information Center

    Pietro, David C.

    1996-01-01

    According to Frederick Herzberg's studies of employee motivation, humans are driven by motivating factors that allow them to grow psychologically and hygiene factors that help them meet physical needs. Good education conferences can enhance both factors by helping principals refocus their energies, exchange ideas with trusted colleagues, and view…

  11. Ozone Conference II: Abstract Proceedings

    SciTech Connect

    1999-11-01

    Ozone Conference II: Pre- and Post-Harvest Applications Two Years After Gras, was held September 27-28, 1999 in Tulare, California. This conference, sponsored by EPRI's Agricultural Technology Alliance and Southern California Edison's AgTAC facility, was coordinated and organized by the on-site ATA-AgTAC Regional Center. Approximately 175 people attended the day-and-a-half conference at AgTAC. During the Conference twenty-two presentations were given on ozone food processing and agricultural applications. Included in the presentations were topics on: (1) Ozone fumigation; (2) Ozone generation techniques; (3) System and design applications; (4) Prewater treatment requirements; (5) Poultry water reuse; (6) Soil treatments with ozone gas; and (7) Post-harvest aqueous and gaseous ozone research results. A live videoconference between Tulare and Washington, D.C. was held to discuss the regulators' view from inside the beltway. Attendees participated in two Roundtable Question and Answer sessions and visited fifteen exhibits and demonstrations. The attendees included university and governmental researchers, regulators, consultants and industry experts, technology developers and providers, and corporate and individual end-users. This report is comprised of the Abstracts of each presentation, biographical sketches for each speaker and a registration/attendees list.

  12. The United Nations Water Conference

    ERIC Educational Resources Information Center

    United Nations and Water, 1977

    1977-01-01

    This Water Conference adapted a set of detailed action recommendations on various aspects of water resources development and management and decided that this set of recommendations would be known as the "Mar del Plata Action Plan." This article presents an abridged version of selected recommendations in the Action Plan. (Author/MA)

  13. Pan Pacific Microgravity Conference -- Outreach

    NASA Technical Reports Server (NTRS)

    2001-01-01

    Teachers, students, and parents listen as scientists explain what is different about the microgravity envirornment of space and why it is a valuable tool for research. This was part of the outreach session of the Pan Pacific Microgravity Conference on May 2, 2001, at the California Science Center.

  14. Pan Pacific Microgravity Conference -- Outreach

    NASA Technical Reports Server (NTRS)

    2001-01-01

    Dr. Chiaki Mukai of Japan's National Space Development Agency (NASDA) speaks to students at the California Science Center during the outreach session of the Pan Pacific Microgravity Conference on May 2, 2001. She flew as a payload specialist on two NASA Space Shuttle missions, STS-65 carrying the second International Microgravity Laboratory (IML-2, 1994) and STS-95 (1998).

  15. Apollo 11 Lunar Science Conference

    ERIC Educational Resources Information Center

    Cochran, Wendell

    1970-01-01

    Report of a conference called to discuss the findings of 142 scientists from their investigations of samples of lunar rock and soil brought back by the Apollo 11 mission. Significant findings reported include the age and composition of the lunar samples, and the absence of water and organic matter. Much discussed was the origin and structure of…

  16. ASTD's 1974 Conference--Highlights

    ERIC Educational Resources Information Center

    Training and Development Journal, 1974

    1974-01-01

    Highlights of speeches presented at the 30th ASTD National Conference in San Francisco are given: S.I. Hayakawa outlined developments in higher education during the 1970's; Joe Batten called for life enrichment, not just job enrichment; and Dorothy Jongeward discussed transactional analysis as a tool for more effective interpersonal relationships.…

  17. Economic Downturn Limits Conference Travel

    ERIC Educational Resources Information Center

    Young, Jeffrey R.

    2009-01-01

    Attendance is down at many academic and professional conferences in higher education this year, and next year's numbers are expected to be far worse, as campus budgets take further beatings. With many colleges limiting travel to professors or administrators who are speaking at events they are attending, will anyone be left in the audience? A new…

  18. IEEE Conference Publications in Libraries.

    ERIC Educational Resources Information Center

    Johnson, Karl E.

    1984-01-01

    Conclusions of surveys (63 libraries, OCLC database, University of Rhode Island users) assessing handling of Institute of Electrical and Electronics Engineers (IEEE) conference publications indicate that most libraries fully catalog these publications using LC cataloging, and library patrons frequently require series access to publications. Eight…

  19. Columbine Author Speaks at Conference

    ERIC Educational Resources Information Center

    Cook, Andrea J.

    2004-01-01

    Brooks Brown, the author of No Easy Answers: The Truth Behind Death at Columbine High School, spoke at the 11th annual Reclaiming Youth International No Disposable Kids conference at Rushmore Plaza Holiday Inn. Brown, who worked with Michael Moore on his Academy Award winning documentary, "Bowling for Columbine," said the letters he…

  20. CIEE 1993 annual conference: Program

    SciTech Connect

    Not Available

    1993-08-01

    The California Institute for Energy efficiency`s third annual conference highlights the results of CIEE-sponsored multiyear research in three programs: Building Energy Efficiency, Air Quality Impacts of Energy Efficiency, and End-Use Resource Planning. Results from scoping studies, Director`s discretionary research, and exploratory research are also featured.