Optimization Methods in Sherpa

NASA Astrophysics Data System (ADS)

Siemiginowska, Aneta; Nguyen, Dan T.; Doe, Stephen M.; Refsdal, Brian L.

2009-09-01

Forward fitting is a standard technique used to model X-ray data. A statistic, usually assumed weighted chi^2 or Poisson likelihood (e.g. Cash), is minimized in the fitting process to obtain a set of the best model parameters. Astronomical models often have complex forms with many parameters that can be correlated (e.g. an absorbed power law). Minimization is not trivial in such setting, as the statistical parameter space becomes multimodal and finding the global minimum is hard. Standard minimization algorithms can be found in many libraries of scientific functions, but they are usually focused on specific functions. However, Sherpa designed as general fitting and modeling application requires very robust optimization methods that can be applied to variety of astronomical data (X-ray spectra, images, timing, optical data etc.). We developed several optimization algorithms in Sherpa targeting a wide range of minimization problems. Two local minimization methods were built: Levenberg-Marquardt algorithm was obtained from MINPACK subroutine LMDIF and modified to achieve the required robustness; and Nelder-Mead simplex method has been implemented in-house based on variations of the algorithm described in the literature. A global search Monte-Carlo method has been implemented following a differential evolution algorithm presented by Storn and Price (1997). We will present the methods in Sherpa and discuss their usage cases. We will focus on the application to Chandra data showing both 1D and 2D examples. This work is supported by NASA contract NAS8-03060 (CXC).

A comparison of various algorithms to extract Magic Formula tyre model coefficients for vehicle dynamics simulations

NASA Astrophysics Data System (ADS)

Vijay Alagappan, A.; Narasimha Rao, K. V.; Krishna Kumar, R.

2015-02-01

Tyre models are a prerequisite for any vehicle dynamics simulation. Tyre models range from the simplest mathematical models that consider only the cornering stiffness to a complex set of formulae. Among all the steady-state tyre models that are in use today, the Magic Formula tyre model is unique and most popular. Though the Magic Formula tyre model is widely used, obtaining the model coefficients from either the experimental or the simulation data is not straightforward due to its nonlinear nature and the presence of a large number of coefficients. A common procedure used for this extraction is the least-squares minimisation that requires considerable experience for initial guesses. Various researchers have tried different algorithms, namely, gradient and Newton-based methods, differential evolution, artificial neural networks, etc. The issues involved in all these algorithms are setting bounds or constraints, sensitivity of the parameters, the features of the input data such as the number of points, noisy data, experimental procedure used such as slip angle sweep or tyre measurement (TIME) procedure, etc. The extracted Magic Formula coefficients are affected by these variants. This paper highlights the issues that are commonly encountered in obtaining these coefficients with different algorithms, namely, least-squares minimisation using trust region algorithms, Nelder-Mead simplex, pattern search, differential evolution, particle swarm optimisation, cuckoo search, etc. A key observation is that not all the algorithms give the same Magic Formula coefficients for a given data. The nature of the input data and the type of the algorithm decide the set of the Magic Formula tyre model coefficients.

Testing calibration routines for LISFLOOD, a distributed hydrological model

NASA Astrophysics Data System (ADS)

Pannemans, B.

2009-04-01

Traditionally hydrological models are considered as difficult to calibrate: their highly non-linearity results in rugged and rough response surfaces were calibration algorithms easily get stuck in local minima. For the calibration of distributed hydrological models two extra factors play an important role: on the one hand they are often costly on computation, thus restricting the feasible number of model runs; on the other hand their distributed nature smooths the response surface, thus facilitating the search for a global minimum. Lisflood is a distributed hydrological model currently used for the European Flood Alert System - EFAS (Van der Knijff et al, 2008). Its upcoming recalibration over more then 200 catchments, each with an average runtime of 2-3 minutes, proved a perfect occasion to put several existing calibration algorithms to the test. The tested routines are Downhill Simplex (DHS, Nelder and Mead, 1965), SCEUA (Duan et Al. 1993), SCEM (Vrugt et al., 2003) and AMALGAM (Vrugt et al., 2008), and they were evaluated on their capability to efficiently converge onto the global minimum and on the spread in the found solutions in repeated runs. The routines were let loose on a simple hyperbolic function, on a Lisflood catchment using model output as observation, and on two Lisflood catchments using real observations (one on the river Inn in the Alps, the other along the downstream stretch of the Elbe). On the mathematical problem and on the catchment with synthetic observations DHS proved to be the fastest and the most efficient in finding a solution. SCEUA and AMALGAM are a slower, but while SCEUA keeps converging on the exact solution, AMALGAM slows down after about 600 runs. For the Lisflood models with real-time observations AMALGAM (hybrid algorithm that combines several other algorithms, we used CMA, PSO and GA) came as fastest out of the tests, and giving comparable results in consecutive runs. However, some more work is needed to tweak the stopping criteria. SCEUA is a bit slower, but has very transparent stopping rules. Both have closed in on the minima after about 600 runs. DHS equals only SCEUA on convergence speed. The stopping criteria we applied so far are too strict, causing it to stop too early. SCEM converges 5-6 times slower. This is a high price for the parameter uncertainty analysis that is simultaneously done. The ease with which all algorithms find the same optimum suggests that we are dealing with a smooth and relatively simple response surface. This leaves room for other deterministic calibration algorithms being smarter than DHS in sliding downhill. PEST seems promising but sofar we haven't managed to get it running with LISFLOOD. • Duan, Q.; Gupta, V. & Sorooshian, S., 1993, Shuffled complex evolution approach for effective and efficient global minimization, J Optim Theory Appl, Kluwer Academic Publishers-Plenum Publishers, 76, 501-521 • Nelder, J. & Mead, R., 1965, A simplex method for function minimization, Comput. J., 7, 308-313 • Van Der Knijff, J. M.; Younis, J. & De Roo, A. P. J., 2008, LISFLOOD: a GIS-based distributed model for river basin scale water balance and flood simulation, International Journal of Geographical Information Science, • Vrugt, J.; Gupta, H.; Bouten, W. & Sorooshian, S., 2003, A Shuffled Complex Evolution Metropolis algorithm for optimization and uncertainty assessment of hydrologic model parameters, Water Resour. Res., 39 • Vrugt, J.; Robinson, B. & Hyman, J., 2008, Self-Adaptive Multimethod Search for Global Optimization in Real-Parameter Spaces, IEEE Trans Evol Comput, IEEE,

Mars Entry Atmospheric Data System Modelling and Algorithm Development

NASA Technical Reports Server (NTRS)

Karlgaard, Christopher D.; Beck, Roger E.; OKeefe, Stephen A.; Siemers, Paul; White, Brady; Engelund, Walter C.; Munk, Michelle M.

2009-01-01

The Mars Entry Atmospheric Data System (MEADS) is being developed as part of the Mars Science Laboratory (MSL), Entry, Descent, and Landing Instrumentation (MEDLI) project. The MEADS project involves installing an array of seven pressure transducers linked to ports on the MSL forebody to record the surface pressure distribution during atmospheric entry. These measured surface pressures are used to generate estimates of atmospheric quantities based on modeled surface pressure distributions. In particular, the quantities to be estimated from the MEADS pressure measurements include the total pressure, dynamic pressure, Mach number, angle of attack, and angle of sideslip. Secondary objectives are to estimate atmospheric winds by coupling the pressure measurements with the on-board Inertial Measurement Unit (IMU) data. This paper provides details of the algorithm development, MEADS system performance based on calibration, and uncertainty analysis for the aerodynamic and atmospheric quantities of interest. The work presented here is part of the MEDLI performance pre-flight validation and will culminate with processing flight data after Mars entry in 2012.

A Partitioning and Bounded Variable Algorithm for Linear Programming

ERIC Educational Resources Information Center

Sheskin, Theodore J.

2006-01-01

An interesting new partitioning and bounded variable algorithm (PBVA) is proposed for solving linear programming problems. The PBVA is a variant of the simplex algorithm which uses a modified form of the simplex method followed by the dual simplex method for bounded variables. In contrast to the two-phase method and the big M method, the PBVA does…

Optimization of Angular-Momentum Biases of Reaction Wheels

NASA Technical Reports Server (NTRS)

Lee, Clifford; Lee, Allan

2008-01-01

RBOT [RWA Bias Optimization Tool (wherein RWA signifies Reaction Wheel Assembly )] is a computer program designed for computing angular momentum biases for reaction wheels used for providing spacecraft pointing in various directions as required for scientific observations. RBOT is currently deployed to support the Cassini mission to prevent operation of reaction wheels at unsafely high speeds while minimizing time in undesirable low-speed range, where elasto-hydrodynamic lubrication films in bearings become ineffective, leading to premature bearing failure. The problem is formulated as a constrained optimization problem in which maximum wheel speed limit is a hard constraint and a cost functional that increases as speed decreases below a low-speed threshold. The optimization problem is solved using a parametric search routine known as the Nelder-Mead simplex algorithm. To increase computational efficiency for extended operation involving large quantity of data, the algorithm is designed to (1) use large time increments during intervals when spacecraft attitudes or rates of rotation are nearly stationary, (2) use sinusoidal-approximation sampling to model repeated long periods of Earth-point rolling maneuvers to reduce computational loads, and (3) utilize an efficient equation to obtain wheel-rate profiles as functions of initial wheel biases based on conservation of angular momentum (in an inertial frame) using pre-computed terms.

Imfit: A Fast, Flexible Program for Astronomical Image Fitting

NASA Astrophysics Data System (ADS)

Erwin, Peter

2014-08-01

Imift is an open-source astronomical image-fitting program specialized for galaxies but potentially useful for other sources, which is fast, flexible, and highly extensible. Its object-oriented design allows new types of image components (2D surface-brightness functions) to be easily written and added to the program. Image functions provided with Imfit include Sersic, exponential, and Gaussian galaxy decompositions along with Core-Sersic and broken-exponential profiles, elliptical rings, and three components that perform line-of-sight integration through 3D luminosity-density models of disks and rings seen at arbitrary inclinations. Available minimization algorithms include Levenberg-Marquardt, Nelder-Mead simplex, and Differential Evolution, allowing trade-offs between speed and decreased sensitivity to local minima in the fit landscape. Minimization can be done using the standard chi^2 statistic (using either data or model values to estimate per-pixel Gaussian errors, or else user-supplied error images) or the Cash statistic; the latter is particularly appropriate for cases of Poisson data in the low-count regime. The C++ source code for Imfit is available under the GNU Public License.

4D Cone-beam CT reconstruction using a motion model based on principal component analysis

PubMed Central

Staub, David; Docef, Alen; Brock, Robert S.; Vaman, Constantin; Murphy, Martin J.

2011-01-01

Purpose: To provide a proof of concept validation of a novel 4D cone-beam CT (4DCBCT) reconstruction algorithm and to determine the best methods to train and optimize the algorithm. Methods: The algorithm animates a patient fan-beam CT (FBCT) with a patient specific parametric motion model in order to generate a time series of deformed CTs (the reconstructed 4DCBCT) that track the motion of the patient anatomy on a voxel by voxel scale. The motion model is constrained by requiring that projections cast through the deformed CT time series match the projections of the raw patient 4DCBCT. The motion model uses a basis of eigenvectors that are generated via principal component analysis (PCA) of a training set of displacement vector fields (DVFs) that approximate patient motion. The eigenvectors are weighted by a parameterized function of the patient breathing trace recorded during 4DCBCT. The algorithm is demonstrated and tested via numerical simulation. Results: The algorithm is shown to produce accurate reconstruction results for the most complicated simulated motion, in which voxels move with a pseudo-periodic pattern and relative phase shifts exist between voxels. The tests show that principal component eigenvectors trained on DVFs from a novel 2D/3D registration method give substantially better results than eigenvectors trained on DVFs obtained by conventionally registering 4DCBCT phases reconstructed via filtered backprojection. Conclusions: Proof of concept testing has validated the 4DCBCT reconstruction approach for the types of simulated data considered. In addition, the authors found the 2D/3D registration approach to be our best choice for generating the DVF training set, and the Nelder-Mead simplex algorithm the most robust optimization routine. PMID:22149852

Determining index of refraction from polarimetric hyperspectral radiance measurements

NASA Astrophysics Data System (ADS)

Martin, Jacob A.; Gross, Kevin C.

2015-09-01

Polarimetric hyperspectral imaging (P-HSI) combines two of the most common remote sensing modalities. This work leverages the combination of these techniques to improve material classification. Classifying and identifying materials requires parameters which are invariant to changing viewing conditions, and most often a material's reflectivity or emissivity is used. Measuring these most often requires assumptions be made about the material and atmospheric conditions. Combining both polarimetric and hyperspectral imaging, we propose a method to remotely estimate the index of refraction of a material. In general, this is an underdetermined problem because both the real and imaginary components of index of refraction are unknown at every spectral point. By modeling the spectral variation of the index of refraction using a few parameters, however, the problem can be made overdetermined. A number of different functions can be used to describe this spectral variation, and some are discussed here. Reducing the number of spectral parameters to fit allows us to add parameters which estimate atmospheric downwelling radiance and transmittance. Additionally, the object temperature is added as a fit parameter. The set of these parameters that best replicate the measured data is then found using a bounded Nelder-Mead simplex search algorithm. Other search algorithms are also examined and discussed. Results show that this technique has promise but also some limitations, which are the subject of ongoing work.

An Automatic Multidocument Text Summarization Approach Based on Naïve Bayesian Classifier Using Timestamp Strategy

PubMed Central

Ramanujam, Nedunchelian; Kaliappan, Manivannan

2016-01-01

Nowadays, automatic multidocument text summarization systems can successfully retrieve the summary sentences from the input documents. But, it has many limitations such as inaccurate extraction to essential sentences, low coverage, poor coherence among the sentences, and redundancy. This paper introduces a new concept of timestamp approach with Naïve Bayesian Classification approach for multidocument text summarization. The timestamp provides the summary an ordered look, which achieves the coherent looking summary. It extracts the more relevant information from the multiple documents. Here, scoring strategy is also used to calculate the score for the words to obtain the word frequency. The higher linguistic quality is estimated in terms of readability and comprehensibility. In order to show the efficiency of the proposed method, this paper presents the comparison between the proposed methods with the existing MEAD algorithm. The timestamp procedure is also applied on the MEAD algorithm and the results are examined with the proposed method. The results show that the proposed method results in lesser time than the existing MEAD algorithm to execute the summarization process. Moreover, the proposed method results in better precision, recall, and F-score than the existing clustering with lexical chaining approach. PMID:27034971

The cancellous bone multiscale morphology-elasticity relationship.

PubMed

Agić, Ante; Nikolić, Vasilije; Mijović, Budimir

2006-06-01

The cancellous bone effective properties relations are analysed on multiscale across two aspects; properties of representative volume element on micro scale and statistical measure of trabecular trajectory orientation on mesoscale. Anisotropy of the microstructure is described across fabric tensor measure with trajectory orientation tensor as bridging scale connection. The scatter measured data (elastic modulus, trajectory orientation, apparent density) from compression test are fitted by stochastic interpolation procedure. The engineering constants of the elasticity tensor are estimated by last square fitt procedure in multidimensional space by Nelder-Mead simplex. The multiaxial failure surface in strain space is constructed and interpolated by modified super-ellipsoid.

Detection of Fiber Layer-Up Lamination Order of CFRP Composite Using Thermal-Wave Radar Imaging

NASA Astrophysics Data System (ADS)

Wang, Fei; Liu, Junyan; Liu, Yang; Wang, Yang; Gong, Jinlong

2016-09-01

In this paper, thermal-wave radar imaging (TWRI) is used as a nondestructive inspection method to evaluate carbon-fiber-reinforced-polymer (CFRP) composite. An inverse methodology that combines TWRI with numerical optimization technique is proposed to determine the fiber layer-up lamination sequences of anisotropic CFRP composite. A 7-layer CFRP laminate [0°/45°/90°/0°]_{{s}} is heated by a chirp-modulated Gaussian laser beam, and then finite element method (FEM) is employed to calculate the temperature field of CFRP laminates. The phase based on lock-in correlation between reference chirp signal and the thermal-wave signal is performed to obtain the phase image of TWRI, and the least square method is applied to reconstruct the cost function that minimizes the square of the difference between the phase of TWRI inspection and numerical calculation. A hybrid algorithm that combines the simulation annealing with Nelder-Mead simplex research method is employed to solve the reconstructed cost function and find the global optimal solution of the layer-up sequences of CFRP composite. The result shows the feasibility of estimating the fiber layer-up lamination sequences of CFRP composite with optimal discrete and constraint conditions.

Testing Nelder-Mead based repulsion algorithms for multiple roots of nonlinear systems via a two-level factorial design of experiments.

PubMed

Ramadas, Gisela C V; Rocha, Ana Maria A C; Fernandes, Edite M G P

2015-01-01

This paper addresses the challenging task of computing multiple roots of a system of nonlinear equations. A repulsion algorithm that invokes the Nelder-Mead (N-M) local search method and uses a penalty-type merit function based on the error function, known as 'erf', is presented. In the N-M algorithm context, different strategies are proposed to enhance the quality of the solutions and improve the overall efficiency. The main goal of this paper is to use a two-level factorial design of experiments to analyze the statistical significance of the observed differences in selected performance criteria produced when testing different strategies in the N-M based repulsion algorithm. The main goal of this paper is to use a two-level factorial design of experiments to analyze the statistical significance of the observed differences in selected performance criteria produced when testing different strategies in the N-M based repulsion algorithm.

Strong Tracking Spherical Simplex-Radial Cubature Kalman Filter for Maneuvering Target Tracking.

PubMed

Liu, Hua; Wu, Wen

2017-03-31

Conventional spherical simplex-radial cubature Kalman filter (SSRCKF) for maneuvering target tracking may decline in accuracy and even diverge when a target makes abrupt state changes. To overcome this problem, a novel algorithm named strong tracking spherical simplex-radial cubature Kalman filter (STSSRCKF) is proposed in this paper. The proposed algorithm uses the spherical simplex-radial (SSR) rule to obtain a higher accuracy than cubature Kalman filter (CKF) algorithm. Meanwhile, by introducing strong tracking filter (STF) into SSRCKF and modifying the predicted states' error covariance with a time-varying fading factor, the gain matrix is adjusted on line so that the robustness of the filter and the capability of dealing with uncertainty factors is improved. In this way, the proposed algorithm has the advantages of both STF's strong robustness and SSRCKF's high accuracy. Finally, a maneuvering target tracking problem with abrupt state changes is used to test the performance of the proposed filter. Simulation results show that the STSSRCKF algorithm can get better estimation accuracy and greater robustness for maneuvering target tracking.

Strong Tracking Spherical Simplex-Radial Cubature Kalman Filter for Maneuvering Target Tracking

PubMed Central

Liu, Hua; Wu, Wen

2017-01-01

Conventional spherical simplex-radial cubature Kalman filter (SSRCKF) for maneuvering target tracking may decline in accuracy and even diverge when a target makes abrupt state changes. To overcome this problem, a novel algorithm named strong tracking spherical simplex-radial cubature Kalman filter (STSSRCKF) is proposed in this paper. The proposed algorithm uses the spherical simplex-radial (SSR) rule to obtain a higher accuracy than cubature Kalman filter (CKF) algorithm. Meanwhile, by introducing strong tracking filter (STF) into SSRCKF and modifying the predicted states’ error covariance with a time-varying fading factor, the gain matrix is adjusted on line so that the robustness of the filter and the capability of dealing with uncertainty factors is improved. In this way, the proposed algorithm has the advantages of both STF’s strong robustness and SSRCKF’s high accuracy. Finally, a maneuvering target tracking problem with abrupt state changes is used to test the performance of the proposed filter. Simulation results show that the STSSRCKF algorithm can get better estimation accuracy and greater robustness for maneuvering target tracking. PMID:28362347

Interacting Multiple Model (IMM) Fifth-Degree Spherical Simplex-Radial Cubature Kalman Filter for Maneuvering Target Tracking

PubMed Central

Liu, Hua; Wu, Wen

2017-01-01

For improving the tracking accuracy and model switching speed of maneuvering target tracking in nonlinear systems, a new algorithm named the interacting multiple model fifth-degree spherical simplex-radial cubature Kalman filter (IMM5thSSRCKF) is proposed in this paper. The new algorithm is a combination of the interacting multiple model (IMM) filter and the fifth-degree spherical simplex-radial cubature Kalman filter (5thSSRCKF). The proposed algorithm makes use of Markov process to describe the switching probability among the models, and uses 5thSSRCKF to deal with the state estimation of each model. The 5thSSRCKF is an improved filter algorithm, which utilizes the fifth-degree spherical simplex-radial rule to improve the filtering accuracy. Finally, the tracking performance of the IMM5thSSRCKF is evaluated by simulation in a typical maneuvering target tracking scenario. Simulation results show that the proposed algorithm has better tracking performance and quicker model switching speed when disposing maneuver models compared with the interacting multiple model unscented Kalman filter (IMMUKF), the interacting multiple model cubature Kalman filter (IMMCKF) and the interacting multiple model fifth-degree cubature Kalman filter (IMM5thCKF). PMID:28608843

Interacting Multiple Model (IMM) Fifth-Degree Spherical Simplex-Radial Cubature Kalman Filter for Maneuvering Target Tracking.

PubMed

Liu, Hua; Wu, Wen

2017-06-13

For improving the tracking accuracy and model switching speed of maneuvering target tracking in nonlinear systems, a new algorithm named the interacting multiple model fifth-degree spherical simplex-radial cubature Kalman filter (IMM5thSSRCKF) is proposed in this paper. The new algorithm is a combination of the interacting multiple model (IMM) filter and the fifth-degree spherical simplex-radial cubature Kalman filter (5thSSRCKF). The proposed algorithm makes use of Markov process to describe the switching probability among the models, and uses 5thSSRCKF to deal with the state estimation of each model. The 5thSSRCKF is an improved filter algorithm, which utilizes the fifth-degree spherical simplex-radial rule to improve the filtering accuracy. Finally, the tracking performance of the IMM5thSSRCKF is evaluated by simulation in a typical maneuvering target tracking scenario. Simulation results show that the proposed algorithm has better tracking performance and quicker model switching speed when disposing maneuver models compared with the interacting multiple model unscented Kalman filter (IMMUKF), the interacting multiple model cubature Kalman filter (IMMCKF) and the interacting multiple model fifth-degree cubature Kalman filter (IMM5thCKF).

Fermentation of molasses using a thermotolerant yeast, Kluyveromyces marxianus IMB3: simplex optimisation of media supplements.

PubMed

Gough, S; Flynn, O; Hack, C J; Marchant, R

1996-09-01

The use of molasses as a substrate for ethanol production by the thermotolerant yeast Kluyveromyces marxianus var. marxianus was investigated at 45 degrees C. A maximum ethanol concentration of 7.4% (v/v) was produced from unsupplemented molasses at a concentration of 23% (v/v). The effect on ethanol production of increasing the sucrose concentration in 23% (v/v) molasses was determined. Increased sucrose concentration had a similar detrimental effect on the final ethanol produced as the increase in molasses concentration. This indicated that the effect may be due to increased osmotic activity as opposed to other components in the molasses. The optimum concentration of the supplements nitrogen, magnesium, potassium and fatty acid for maximum ethanol production rate was determined using the Nelder and Mead (Computer J 7:308-313, 1965) simplex optimisation method. The optimum concentration of the supplements were 0.576 g1(-1) magnesium sulphate, 0.288 g1(-1) potassium dihydrogen phosphate and 0.36% (v/v) linseed oil. Added nitrogen in the form of ammonium sulphate did not affect the ethanol production rate.

Non-ambiguous recovery of Biot poroelastic parameters of cellular panels using ultrasonicwaves

NASA Astrophysics Data System (ADS)

Ogam, Erick; Fellah, Z. E. A.; Sebaa, Naima; Groby, J.-P.

2011-03-01

The inverse problem of the recovery of the poroelastic parameters of open-cell soft plastic foam panels is solved by employing transmitted ultrasonic waves (USW) and the Biot-Johnson-Koplik-Champoux-Allard (BJKCA) model. It is shown by constructing the objective functional given by the total square of the difference between predictions from the BJKCA interaction model and experimental data obtained with transmitted USW that the inverse problem is ill-posed, since the functional exhibits several local minima and maxima. In order to solve this problem, which is beyond the capability of most off-the-shelf iterative nonlinear least squares optimization algorithms (such as the Levenberg Marquadt or Nelder-Mead simplex methods), simple strategies are developed. The recovered acoustic parameters are compared with those obtained using simpler interaction models and a method employing asymptotic phase velocity of the transmitted USW. The retrieved elastic moduli are validated by solving an inverse vibration spectroscopy problem with data obtained from beam-like specimens cut from the panels using an equivalent solid elastodynamic model as estimator. The phase velocities are reconstructed using computed, measured resonance frequencies and a time-frequency decomposition of transient waves induced in the beam specimen. These confirm that the elastic parameters recovered using vibration are valid over the frequency range ofstudy.

Calibration of a dual-PTZ camera system for stereo vision

NASA Astrophysics Data System (ADS)

Chang, Yau-Zen; Hou, Jung-Fu; Tsao, Yi Hsiang; Lee, Shih-Tseng

2010-08-01

In this paper, we propose a calibration process for the intrinsic and extrinsic parameters of dual-PTZ camera systems. The calibration is based on a complete definition of six coordinate systems fixed at the image planes, and the pan and tilt rotation axes of the cameras. Misalignments between estimated and ideal coordinates of image corners are formed into cost values to be solved by the Nelder-Mead simplex optimization method. Experimental results show that the system is able to obtain 3D coordinates of objects with a consistent accuracy of 1 mm when the distance between the dual-PTZ camera set and the objects are from 0.9 to 1.1 meters.

Finding all solutions of nonlinear equations using the dual simplex method

NASA Astrophysics Data System (ADS)

Yamamura, Kiyotaka; Fujioka, Tsuyoshi

2003-03-01

Recently, an efficient algorithm has been proposed for finding all solutions of systems of nonlinear equations using linear programming. This algorithm is based on a simple test (termed the LP test) for nonexistence of a solution to a system of nonlinear equations using the dual simplex method. In this letter, an improved version of the LP test algorithm is proposed. By numerical examples, it is shown that the proposed algorithm could find all solutions of a system of 300 nonlinear equations in practical computation time.

On global optimization using an estimate of Lipschitz constant and simplicial partition

NASA Astrophysics Data System (ADS)

Gimbutas, Albertas; Žilinskas, Antanas

2016-10-01

A new algorithm is proposed for finding the global minimum of a multi-variate black-box Lipschitz function with an unknown Lipschitz constant. The feasible region is initially partitioned into simplices; in the subsequent iteration, the most suitable simplices are selected and bisected via the middle point of the longest edge. The suitability of a simplex for bisection is evaluated by minimizing of a surrogate function which mimics the lower bound for the considered objective function over that simplex. The surrogate function is defined using an estimate of the Lipschitz constant and the objective function values at the vertices of a simplex. The novelty of the algorithm is the sophisticated method of estimating the Lipschitz constant, and the appropriate method to minimize the surrogate function. The proposed algorithm was tested using 600 random test problems of different complexity, showing competitive results with two popular advanced algorithms which are based on similar assumptions.

JPLEX: Java Simplex Implementation with Branch-and-Bound Search for Automated Test Assembly

ERIC Educational Resources Information Center

Park, Ryoungsun; Kim, Jiseon; Dodd, Barbara G.; Chung, Hyewon

2011-01-01

JPLEX, short for Java simPLEX, is an automated test assembly (ATA) program. It is a mixed integer linear programming (MILP) solver written in Java. It reads in a configuration file, solves the minimization problem, and produces an output file for postprocessing. It implements the simplex algorithm to create a fully relaxed solution and…

Optimization of design parameters of low-energy buildings

NASA Astrophysics Data System (ADS)

Vala, Jiří; Jarošová, Petra

2017-07-01

Evaluation of temperature development and related consumption of energy required for heating, air-conditioning, etc. in low-energy buildings requires the proper physical analysis, covering heat conduction, convection and radiation, including beam and diffusive components of solar radiation, on all building parts and interfaces. The system approach and the Fourier multiplicative decomposition together with the finite element technique offers the possibility of inexpensive and robust numerical and computational analysis of corresponding direct problems, as well as of the optimization ones with several design variables, using the Nelder-Mead simplex method. The practical example demonstrates the correlation between such numerical simulations and the time series of measurements of energy consumption on a small family house in Ostrov u Macochy (35 km northern from Brno).

Optimization techniques for integrating spatial data

USGS Publications Warehouse

Herzfeld, U.C.; Merriam, D.F.

1995-01-01

Two optimization techniques ta predict a spatial variable from any number of related spatial variables are presented. The applicability of the two different methods for petroleum-resource assessment is tested in a mature oil province of the Midcontinent (USA). The information on petroleum productivity, usually not directly accessible, is related indirectly to geological, geophysical, petrographical, and other observable data. This paper presents two approaches based on construction of a multivariate spatial model from the available data to determine a relationship for prediction. In the first approach, the variables are combined into a spatial model by an algebraic map-comparison/integration technique. Optimal weights for the map comparison function are determined by the Nelder-Mead downhill simplex algorithm in multidimensions. Geologic knowledge is necessary to provide a first guess of weights to start the automatization, because the solution is not unique. In the second approach, active set optimization for linear prediction of the target under positivity constraints is applied. Here, the procedure seems to select one variable from each data type (structure, isopachous, and petrophysical) eliminating data redundancy. Automating the determination of optimum combinations of different variables by applying optimization techniques is a valuable extension of the algebraic map-comparison/integration approach to analyzing spatial data. Because of the capability of handling multivariate data sets and partial retention of geographical information, the approaches can be useful in mineral-resource exploration. ?? 1995 International Association for Mathematical Geology.

Algorithm for retrieving vegetative canopy and leaf parameters from multi- and hyperspectral imagery

NASA Astrophysics Data System (ADS)

Borel, Christoph

2009-05-01

In recent years hyper-spectral data has been used to retrieve information about vegetative canopies such as leaf area index and canopy water content. For the environmental scientist these two parameters are valuable, but there is potentially more information to be gained as high spatial resolution data becomes available. We developed an Amoeba (Nelder-Mead or Simplex) based program to invert a vegetative canopy radiosity model coupled with a leaf (PROSPECT5) reflectance model and modeled for the background reflectance (e.g. soil, water, leaf litter) to a measured reflectance spectrum. The PROSPECT5 leaf model has five parameters: leaf structure parameter Nstru, chlorophyll a+b concentration Cab, carotenoids content Car, equivalent water thickness Cw and dry matter content Cm. The canopy model has two parameters: total leaf area index (LAI) and number of layers. The background reflectance model is either a single reflectance spectrum from a spectral library() derived from a bare area pixel on an image or a linear mixture of soil spectra. We summarize the radiosity model of a layered canopy and give references to the leaf/needle models. The method is then tested on simulated and measured data. We investigate the uniqueness, limitations and accuracy of the retrieved parameters on canopy parameters (low, medium and high leaf area index) spectral resolution (32 to 211 band hyperspectral), sensor noise and initial conditions.

Multivariate Spline Algorithms for CAGD

NASA Technical Reports Server (NTRS)

Boehm, W.

1985-01-01

Two special polyhedra present themselves for the definition of B-splines: a simplex S and a box or parallelepiped B, where the edges of S project into an irregular grid, while the edges of B project into the edges of a regular grid. More general splines may be found by forming linear combinations of these B-splines, where the three-dimensional coefficients are called the spline control points. Univariate splines are simplex splines, where s = 1, whereas splines over a regular triangular grid are box splines, where s = 2. Two simple facts render the development of the construction of B-splines: (1) any face of a simplex or a box is again a simplex or box but of lower dimension; and (2) any simplex or box can be easily subdivided into smaller simplices or boxes. The first fact gives a geometric approach to Mansfield-like recursion formulas that express a B-spline in B-splines of lower order, where the coefficients depend on x. By repeated recursion, the B-spline will be expressed as B-splines of order 1; i.e., piecewise constants. In the case of a simplex spline, the second fact gives a so-called insertion algorithm that constructs the new control points if an additional knot is inserted.

Chaos control in solar fed DC-DC boost converter by optimal parameters using nelder-mead algorithm powered enhanced BFOA

NASA Astrophysics Data System (ADS)

Sudhakar, N.; Rajasekar, N.; Akhil, Saya; Jyotheeswara Reddy, K.

2017-11-01

The boost converter is the most desirable DC-DC power converter for renewable energy applications for its favorable continuous input current characteristics. In other hand, these DC-DC converters known as practical nonlinear systems are prone to several types of nonlinear phenomena including bifurcation, quasiperiodicity, intermittency and chaos. These undesirable effects has to be controlled for maintaining normal periodic operation of the converter and to ensure the stability. This paper presents an effective solution to control the chaos in solar fed DC-DC boost converter since the converter experiences wide range of input power variation which leads to chaotic phenomena. Controlling of chaos is significantly achieved using optimal circuit parameters obtained through Nelder-Mead Enhanced Bacterial Foraging Optimization Algorithm. The optimization renders the suitable parameters in minimum computational time. The results are compared with the traditional methods. The obtained results of the proposed system ensures the operation of the converter within the controllable region.

Recovery of the parameters of cancellous bone by inversion of effective velocities, and transmission and reflection coefficients

NASA Astrophysics Data System (ADS)

Buchanan, James L.; Gilbert, Robert P.; Ou, Miao-jung Y.

2011-12-01

Estimating the parameters of an elastic or poroelastic medium from reflected or transmitted acoustic data is an important but difficult problem. Use of the Nelder-Mead simplex method to minimize an objective function measuring the discrepancy between some observable and its value calculated from a model for a trial set of parameters has been tried by several authors. In this paper, the difficulty with this direct approach, which is the existence of numerous local minima of the objective function, is documented for the in vitro experiment in which a specimen in a water tank is subject to an ultrasonic pulse. An indirect approach, based on the numerical solution of the equations for a set of ‘effective’ velocities and transmission coefficients, is then observed empirically to ameliorate the difficulties posed by the direct approach.

Statistical simplex approach to primary and secondary color correction in thick lens assemblies

NASA Astrophysics Data System (ADS)

Ament, Shelby D. V.; Pfisterer, Richard

2017-11-01

A glass selection optimization algorithm is developed for primary and secondary color correction in thick lens systems. The approach is based on the downhill simplex method, and requires manipulation of the surface color equations to obtain a single glass-dependent parameter for each lens element. Linear correlation is used to relate this parameter to all other glass-dependent variables. The algorithm provides a statistical distribution of Abbe numbers for each element in the system. Examples of several lenses, from 2-element to 6-element systems, are performed to verify this approach. The optimization algorithm proposed is capable of finding glass solutions with high color correction without requiring an exhaustive search of the glass catalog.

76 FR 2579 - Safety Zone; Lake Mead Intake Construction, Lake Mead, Boulder City, NV

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-14

...-AA00 Safety Zone; Lake Mead Intake Construction, Lake Mead, Boulder City, NV AGENCY: Coast Guard, DHS... waters of Lake Mead in support of the construction project for Lake Mead's Intake 3 during the first 6... blasting operations for the placement of a water intake pipe in Lake Mead during the first 6 months of 2011...

75 FR 13232 - Safety Zone; Lake Mead Intake Construction, Lake Mead, Boulder City, NV

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-19

...-AA00 Safety Zone; Lake Mead Intake Construction, Lake Mead, Boulder City, NV AGENCY: Coast Guard, DHS... waters of Lake Mead in support of the construction project for Lake Mead's Intake 3. This safety zone is... for the placement of an Intake Pipe from Lake Mead throughout 2010. This safety zone is necessary to...

Likelihood-based confidence intervals for estimating floods with given return periods

NASA Astrophysics Data System (ADS)

Martins, Eduardo Sávio P. R.; Clarke, Robin T.

1993-06-01

This paper discusses aspects of the calculation of likelihood-based confidence intervals for T-year floods, with particular reference to (1) the two-parameter gamma distribution; (2) the Gumbel distribution; (3) the two-parameter log-normal distribution, and other distributions related to the normal by Box-Cox transformations. Calculation of the confidence limits is straightforward using the Nelder-Mead algorithm with a constraint incorporated, although care is necessary to ensure convergence either of the Nelder-Mead algorithm, or of the Newton-Raphson calculation of maximum-likelihood estimates. Methods are illustrated using records from 18 gauging stations in the basin of the River Itajai-Acu, State of Santa Catarina, southern Brazil. A small and restricted simulation compared likelihood-based confidence limits with those given by use of the central limit theorem; for the same confidence probability, the confidence limits of the simulation were wider than those of the central limit theorem, which failed more frequently to contain the true quantile being estimated. The paper discusses possible applications of likelihood-based confidence intervals in other areas of hydrological analysis.

Parallel optimization algorithms and their implementation in VLSI design

NASA Technical Reports Server (NTRS)

Lee, G.; Feeley, J. J.

1991-01-01

Two new parallel optimization algorithms based on the simplex method are described. They may be executed by a SIMD parallel processor architecture and be implemented in VLSI design. Several VLSI design implementations are introduced. An application example is reported to demonstrate that the algorithms are effective.

A Monte Carlo simulation based inverse propagation method for stochastic model updating

NASA Astrophysics Data System (ADS)

Bao, Nuo; Wang, Chunjie

2015-08-01

This paper presents an efficient stochastic model updating method based on statistical theory. Significant parameters have been selected implementing the F-test evaluation and design of experiments, and then the incomplete fourth-order polynomial response surface model (RSM) has been developed. Exploiting of the RSM combined with Monte Carlo simulation (MCS), reduces the calculation amount and the rapid random sampling becomes possible. The inverse uncertainty propagation is given by the equally weighted sum of mean and covariance matrix objective functions. The mean and covariance of parameters are estimated synchronously by minimizing the weighted objective function through hybrid of particle-swarm and Nelder-Mead simplex optimization method, thus the better correlation between simulation and test is achieved. Numerical examples of a three degree-of-freedom mass-spring system under different conditions and GARTEUR assembly structure validated the feasibility and effectiveness of the proposed method.

33 CFR 165.T11-281 - Safety Zone; Lake Mead Intake Construction; Lake Mead, Boulder City, NV.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Safety Zone; Lake Mead Intake Construction; Lake Mead, Boulder City, NV. 165.T11-281 Section 165.T11-281 Navigation and Navigable Waters... Coast Guard District § 165.T11-281 Safety Zone; Lake Mead Intake Construction; Lake Mead, Boulder City...

Ames Women's Influence Network (WIN) Hidden Figures talk with "Computers" Carolyn Hofstetter and Carol Mead co-sponsored by the AAAG

NASA Image and Video Library

2017-02-01

Ames Women's Influence Network (WIN) Hidden Figures talk with "Computers" Carolyn Hofsetter and Carol Mead co-sponsored by the AAAG. clockwise Jack Boyd, Miss Mead daughter of Carol Mead, Carol Mead and Carolyn Hofstetter

Field Results from Three Campaigns to Validate the Performance of the Miniaturized Laser Heterodyne Radiometer (Mini-LHR) for Measuring Carbon Dioxide and Methane in the Atmospheric Column

NASA Technical Reports Server (NTRS)

Miller, J. Houston; Clarke, Greg B.; Melroy, Hilary; Ott, Lesley; Steel, Emily Wilson

2014-01-01

In a collaboration between NASA GSFC and GWU, a low-cost, surface instrument is being developed that can continuously monitor key carbon cycle gases in the atmospheric column: carbon dioxide (CO2) and methane (CH4). The instrument is based on a miniaturized, laser heterodyne radiometer (LHR) using near infrared (NIR) telecom lasers. Despite relatively weak absorption line strengths in this spectral region, spectrallyresolved atmospheric column absorptions for these two molecules fall in the range of 60-80% and thus sensitive and precise measurements of column concentrations are possible. In the last year, the instrument was deployed for field measurements at Park Falls, Wisconsin; Castle Airport near Atwater, California; and at the NOAA Mauna Loa Observatory in Hawaii. For each subsequent campaign, improvement in the figures of merit for the instrument has been observed. In the latest work the absorbance noise is approaching 0.002 optical density (OD) noise on a 1.8 OD signal. An overview of the measurement campaigns and the data retrieval algorithm for the calculation of column concentrations will be presented. For light transmission through the atmosphere, it is necessary to account for variation of pressure, temperature, composition, and refractive index through the atmosphere that are all functions of latitude, longitude, time of day, altitude, etc. For temperature, pressure, and humidity profiles with altitude we use the Modern-Era Retrospective Analysis for Research and Applications (MERRA) data. Spectral simulation is accomplished by integrating short-path segments along the trajectory using the SpecSyn spectral simulation suite developed at GW. Column concentrations are extracted by minimizing residuals between observed and modeled spectrum using the Nelder-Mead simplex algorithm. We will also present an assessment of uncertainty in the reported concentrations from assumptions made in the meteorological data, LHR instrument and tracker noise, and radio frequency bandwidth and describe additional future goals in instrument development and deployment target

Hybrid real-code ant colony optimisation for constrained mechanical design

NASA Astrophysics Data System (ADS)

Pholdee, Nantiwat; Bureerat, Sujin

2016-01-01

This paper proposes a hybrid meta-heuristic based on integrating a local search simplex downhill (SDH) method into the search procedure of real-code ant colony optimisation (ACOR). This hybridisation leads to five hybrid algorithms where a Monte Carlo technique, a Latin hypercube sampling technique (LHS) and a translational propagation Latin hypercube design (TPLHD) algorithm are used to generate an initial population. Also, two numerical schemes for selecting an initial simplex are investigated. The original ACOR and its hybrid versions along with a variety of established meta-heuristics are implemented to solve 17 constrained test problems where a fuzzy set theory penalty function technique is used to handle design constraints. The comparative results show that the hybrid algorithms are the top performers. Using the TPLHD technique gives better results than the other sampling techniques. The hybrid optimisers are a powerful design tool for constrained mechanical design problems.

A fast optimization algorithm for multicriteria intensity modulated proton therapy planning.

PubMed

Chen, Wei; Craft, David; Madden, Thomas M; Zhang, Kewu; Kooy, Hanne M; Herman, Gabor T

2010-09-01

To describe a fast projection algorithm for optimizing intensity modulated proton therapy (IMPT) plans and to describe and demonstrate the use of this algorithm in multicriteria IMPT planning. The authors develop a projection-based solver for a class of convex optimization problems and apply it to IMPT treatment planning. The speed of the solver permits its use in multicriteria optimization, where several optimizations are performed which span the space of possible treatment plans. The authors describe a plan database generation procedure which is customized to the requirements of the solver. The optimality precision of the solver can be specified by the user. The authors apply the algorithm to three clinical cases: A pancreas case, an esophagus case, and a tumor along the rib cage case. Detailed analysis of the pancreas case shows that the algorithm is orders of magnitude faster than industry-standard general purpose algorithms (MOSEK'S interior point optimizer, primal simplex optimizer, and dual simplex optimizer). Additionally, the projection solver has almost no memory overhead. The speed and guaranteed accuracy of the algorithm make it suitable for use in multicriteria treatment planning, which requires the computation of several diverse treatment plans. Additionally, given the low memory overhead of the algorithm, the method can be extended to include multiple geometric instances and proton range possibilities, for robust optimization.

77 FR 58438 - Notice of Request To Release Airport Property

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-20

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Notice of Request To Release Airport... Release Airport Property at the Meade Municipal Airport (MEJ), Meade, KS. SUMMARY: The FAA proposes to rule and invites public comment on the release of land at the Meade Municipal Airport (MEJ), Meade...

Comparison between different direct search optimization algorithms in the calibration of a distributed hydrological model

NASA Astrophysics Data System (ADS)

Campo, Lorenzo; Castelli, Fabio; Caparrini, Francesca

2010-05-01

The modern distributed hydrological models allow the representation of the different surface and subsurface phenomena with great accuracy and high spatial and temporal resolution. Such complexity requires, in general, an equally accurate parametrization. A number of approaches have been followed in this respect, from simple local search method (like Nelder-Mead algorithm), that minimize a cost function representing some distance between model's output and available measures, to more complex approaches like dynamic filters (such as the Ensemble Kalman Filter) that carry on an assimilation of the observations. In this work the first approach was followed in order to compare the performances of three different direct search algorithms on the calibration of a distributed hydrological balance model. The direct search family can be defined as that category of algorithms that make no use of derivatives of the cost function (that is, in general, a black box) and comprehend a large number of possible approaches. The main benefit of this class of methods is that they don't require changes in the implementation of the numerical codes to be calibrated. The first algorithm is the classical Nelder-Mead, often used in many applications and utilized as reference. The second algorithm is a GSS (Generating Set Search) algorithm, built in order to guarantee the conditions of global convergence and suitable for a parallel and multi-start implementation, here presented. The third one is the EGO algorithm (Efficient Global Optimization), that is particularly suitable to calibrate black box cost functions that require expensive computational resource (like an hydrological simulation). EGO minimizes the number of evaluations of the cost function balancing the need to minimize a response surface that approximates the problem and the need to improve the approximation sampling where prediction error may be high. The hydrological model to be calibrated was MOBIDIC, a complete balance distributed model developed at the Department of Civil and Environmental Engineering of the University of Florence. Discussion on the comparisons between the effectiveness of the different algorithms on different cases of study on Central Italy basins is provided.

A shifted hyperbolic augmented Lagrangian-based artificial fish two-swarm algorithm with guaranteed convergence for constrained global optimization

NASA Astrophysics Data System (ADS)

Rocha, Ana Maria A. C.; Costa, M. Fernanda P.; Fernandes, Edite M. G. P.

2016-12-01

This article presents a shifted hyperbolic penalty function and proposes an augmented Lagrangian-based algorithm for non-convex constrained global optimization problems. Convergence to an ?-global minimizer is proved. At each iteration k, the algorithm requires the ?-global minimization of a bound constrained optimization subproblem, where ?. The subproblems are solved by a stochastic population-based metaheuristic that relies on the artificial fish swarm paradigm and a two-swarm strategy. To enhance the speed of convergence, the algorithm invokes the Nelder-Mead local search with a dynamically defined probability. Numerical experiments with benchmark functions and engineering design problems are presented. The results show that the proposed shifted hyperbolic augmented Lagrangian compares favorably with other deterministic and stochastic penalty-based methods.

Ames Women's Influence Network (WIN) Hidden Figures talk with "Computers" Carolyn Hofstetter and Carol Mead co-sponsored by the AAAG.

NASA Image and Video Library

2017-02-01

Ames Women's Influence Network (WIN) Hidden Figures talk with "Computers" Carolyn Hofstetter and Carol Mead co-sponsored by the AAAG. Group photo Front Row left to right; Carolyn Hofstetter, Jack Boyd, Carol Mead Middle Row: Kathy Lee, Annette Randall, Trincella Lewis, Ann Mead (daughter to Carol Mead), Vanessa Kuroda, Netti Halcomb Roozeboom Back Row; Dr Barbara Miller, Dr Wendy Okolo, Denise Snow, Leedjia Svec, Erika Rodriquez, Rhonda Baker, Ray Gilstrap, Glenn Bugos

A Comparison of Trajectory Optimization Methods for the Impulsive Minimum Fuel Rendezvous Problem

NASA Technical Reports Server (NTRS)

Hughes, Steven P.; Mailhe, Laurie M.; Guzman, Jose J.

2003-01-01

In this paper we present, a comparison of trajectory optimization approaches for the minimum fuel rendezvous problem. Both indirect and direct methods are compared for a variety of test cases. The indirect approach is based on primer vector theory. The direct approaches are implemented numerically and include Sequential Quadratic Programming (SQP). Quasi- Newton and Nelder-Meade Simplex. Several cost function parameterizations are considered for the direct approach. We choose one direct approach that appears to be the most flexible. Both the direct and indirect methods are applied to a variety of test cases which are chosen to demonstrate the performance of each method in different flight regimes. The first test case is a simple circular-to-circular coplanar rendezvous. The second test case is an elliptic-to-elliptic line of apsides rotation. The final test case is an orbit phasing maneuver sequence in a highly elliptic orbit. For each test case we present a comparison of the performance of all methods we consider in this paper.

Optimization of natural frequencies of a slender beam shaped in a linear combination of its mode shapes

NASA Astrophysics Data System (ADS)

Silva, Guilherme Augusto Lopes da; Nicoletti, Rodrigo

2017-06-01

This work focuses on the placement of natural frequencies of beams to desired frequency regions. More specifically, we investigate the effects of combining mode shapes to shape a beam to change its natural frequencies, both numerically and experimentally. First, we present a parametric analysis of a shaped beam and we analyze the resultant effects for different boundary conditions and mode shapes. Second, we present an optimization procedure to find the optimum shape of the beam for desired natural frequencies. In this case, we adopt the Nelder-Mead simplex search method, which allows a broad search of the optimum shape in the solution domain. Finally, the obtained results are verified experimentally for a clamped-clamped beam in three different optimization runs. Results show that the method is effective in placing natural frequencies at desired values (experimental results lie within a 10% error to the expected theoretical ones). However, the beam must be axially constrained to have the natural frequencies changed.

Design and optimization of color lookup tables on a simplex topology.

PubMed

Monga, Vishal; Bala, Raja; Mo, Xuan

2012-04-01

An important computational problem in color imaging is the design of color transforms that map color between devices or from a device-dependent space (e.g., RGB/CMYK) to a device-independent space (e.g., CIELAB) and vice versa. Real-time processing constraints entail that such nonlinear color transforms be implemented using multidimensional lookup tables (LUTs). Furthermore, relatively sparse LUTs (with efficient interpolation) are employed in practice because of storage and memory constraints. This paper presents a principled design methodology rooted in constrained convex optimization to design color LUTs on a simplex topology. The use of n simplexes, i.e., simplexes in n dimensions, as opposed to traditional lattices, recently has been of great interest in color LUT design for simplex topologies that allow both more analytically tractable formulations and greater efficiency in the LUT. In this framework of n-simplex interpolation, our central contribution is to develop an elegant iterative algorithm that jointly optimizes the placement of nodes of the color LUT and the output values at those nodes to minimize interpolation error in an expected sense. This is in contrast to existing work, which exclusively designs either node locations or the output values. We also develop new analytical results for the problem of node location optimization, which reduces to constrained optimization of a large but sparse interpolation matrix in our framework. We evaluate our n -simplex color LUTs against the state-of-the-art lattice (e.g., International Color Consortium profiles) and simplex-based techniques for approximating two representative multidimensional color transforms that characterize a CMYK xerographic printer and an RGB scanner, respectively. The results show that color LUTs designed on simplexes offer very significant benefits over traditional lattice-based alternatives in improving color transform accuracy even with a much smaller number of nodes.

Internal rotation of 13 low-mass low-luminosity red giants in the Kepler field

NASA Astrophysics Data System (ADS)

Triana, S. A.; Corsaro, E.; De Ridder, J.; Bonanno, A.; Pérez Hernández, F.; García, R. A.

2017-06-01

Context. The Kepler space telescope has provided time series of red giants of such unprecedented quality that a detailed asteroseismic analysis becomes possible. For a limited set of about a dozen red giants, the observed oscillation frequencies obtained by peak-bagging together with the most recent pulsation codes allowed us to reliably determine the core/envelope rotation ratio. The results so far show that the current models are unable to reproduce the rotation ratios, predicting higher values than what is observed and thus indicating that an efficient angular momentum transport mechanism should be at work. Here we provide an asteroseismic analysis of a sample of 13 low-luminosity low-mass red giant stars observed by Kepler during its first nominal mission. These targets form a subsample of the 19 red giants studied previously, which not only have a large number of extracted oscillation frequencies, but also unambiguous mode identifications. Aims: We aim to extend the sample of red giants for which internal rotation ratios obtained by theoretical modeling of peak-bagged frequencies are available. We also derive the rotation ratios using different methods, and compare the results of these methods with each other. Methods: We built seismic models using a grid search combined with a Nelder-Mead simplex algorithm and obtained rotation averages employing Bayesian inference and inversion methods. We compared these averages with those obtained using a previously developed model-independent method. Results: We find that the cores of the red giants in this sample are rotating 5 to 10 times faster than their envelopes, which is consistent with earlier results. The rotation rates computed from the different methods show good agreement for some targets, while some discrepancies exist for others.

Comparative evaluation of two dose optimization methods for image-guided, highly-conformal, tandem and ovoids cervix brachytherapy planning

NASA Astrophysics Data System (ADS)

Ren, Jiyun; Menon, Geetha; Sloboda, Ron

2013-04-01

Although the Manchester system is still extensively used to prescribe dose in brachytherapy (BT) for locally advanced cervix cancer, many radiation oncology centers are transitioning to 3D image-guided BT, owing to the excellent anatomy definition offered by modern imaging modalities. As automatic dose optimization is highly desirable for 3D image-based BT, this study comparatively evaluates the performance of two optimization methods used in BT treatment planning—Nelder-Mead simplex (NMS) and simulated annealing (SA)—for a cervix BT computer simulation model incorporating a Manchester-style applicator. Eight model cases were constructed based on anatomical structure data (for high risk-clinical target volume (HR-CTV), bladder, rectum and sigmoid) obtained from measurements on fused MR-CT images for BT patients. D90 and V100 for HR-CTV, D2cc for organs at risk (OARs), dose to point A, conformation index and the sum of dwell times within the tandem and ovoids were calculated for optimized treatment plans designed to treat the HR-CTV in a highly conformal manner. Compared to the NMS algorithm, SA was found to be superior as it could perform optimization starting from a range of initial dwell times, while the performance of NMS was strongly dependent on their initial choice. SA-optimized plans also exhibited lower D2cc to OARs, especially the bladder and sigmoid, and reduced tandem dwell times. For cases with smaller HR-CTV having good separation from adjoining OARs, multiple SA-optimized solutions were found which differed markedly from each other and were associated with different choices for initial dwell times. Finally and importantly, the SA method yielded plans with lower dwell time variability compared with the NMS method.

Redefining the Subject, Redefining the Social, Reconsidering Education: George Herbert Mead's Course on Philosophy of Education at the University of Chicago.

ERIC Educational Resources Information Center

Biesta, Gert J. J.

1999-01-01

George Mead's posthumously published works express a genuine philosophy of education. This paper contributes to the reconstruction of Mead's educational philosophy, examining a typescript of student notes from his course on philosophy of education at the University of Chicago. The essay discusses the typescript against the backdrop of Mead's…

33 CFR 162.220 - Hoover Dam, Lake Mead, and Lake Mohave (Colorado River), Ariz.-Nev.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Hoover Dam, Lake Mead, and Lake... REGULATIONS § 162.220 Hoover Dam, Lake Mead, and Lake Mohave (Colorado River), Ariz.-Nev. (a) Lake Mead and... the axis of Hoover Dam and that portion of Lake Mohave (Colorado River) extending 4,500 feet...

33 CFR 162.220 - Hoover Dam, Lake Mead, and Lake Mohave (Colorado River), Ariz.-Nev.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Hoover Dam, Lake Mead, and Lake... REGULATIONS § 162.220 Hoover Dam, Lake Mead, and Lake Mohave (Colorado River), Ariz.-Nev. (a) Lake Mead and... the axis of Hoover Dam and that portion of Lake Mohave (Colorado River) extending 4,500 feet...

33 CFR 162.220 - Hoover Dam, Lake Mead, and Lake Mohave (Colorado River), Ariz.-Nev.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Hoover Dam, Lake Mead, and Lake... REGULATIONS § 162.220 Hoover Dam, Lake Mead, and Lake Mohave (Colorado River), Ariz.-Nev. (a) Lake Mead and... the axis of Hoover Dam and that portion of Lake Mohave (Colorado River) extending 4,500 feet...

33 CFR 162.220 - Hoover Dam, Lake Mead, and Lake Mohave (Colorado River), Ariz.-Nev.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Hoover Dam, Lake Mead, and Lake... REGULATIONS § 162.220 Hoover Dam, Lake Mead, and Lake Mohave (Colorado River), Ariz.-Nev. (a) Lake Mead and... the axis of Hoover Dam and that portion of Lake Mohave (Colorado River) extending 4,500 feet...

Synthesis, conformational analysis, and biological activity of new analogues of thiazole-4-carboxamide adenine dinucleotide (TAD) as IMP dehydrogenase inhibitors.

PubMed

Franchetti, Palmarisa; Cappellacci, Loredana; Pasqualini, Michela; Petrelli, Riccardo; Jayaprakasan, Vetrichelvan; Jayaram, Hiremagalur N; Boyd, Donald B; Jain, Manojkumar D; Grifantini, Mario

2005-03-15

Thiazole-4-carboxamide adenine dinucleotide (TAD) analogues T-2'-MeAD (1) and T-3'-MeAD (2) containing, respectively, a methyl group at the ribose 2'-C-, and 3'-C-position of the adenosine moiety, were prepared as potential selective human inosine monophosphate dehydrogenase (IMPDH) type II inhibitors. The synthesis of heterodinucleotides was carried out by CDI-catalyzed coupling reaction of unprotected 2'-C-methyl- or 3'-C-methyl-adenosine 5'-monophosphate with 2',3'-O-isopropylidene-tiazofurin 5'-monophosphate, and then deisopropylidenation. Biological evaluation of dinucleotides 1 and 2 as inhibitors of recombinant human IMPDH type I and type II resulted in a good activity. Inhibition of both isoenzymes by T-2'-MeAD and T-3'-MeAD was noncompetitive with respect to NAD substrate. Binding of T-3'-MeAD was comparable to that of parent compound TAD, while T-2'-MeAD proved to be a weaker inhibitor. However, no significant difference was found in inhibition of the IMPDH isoenzymes. T-2'-MeAD and T-3'-MeAD were found to inhibit the growth of K562 cells (IC(50) 30.7 and 65.0muM, respectively).

The Use of the Nelder-Mead Method in Determining Projection Parameters for Globe Photographs

NASA Astrophysics Data System (ADS)

Gede, M.

2009-04-01

A photo of a terrestrial or celestial globe can be handled as a map. The only hard issue is its projection: the so-called Tilted Perspective Projection which, if the optical axis of the photo intersects the globe's centre, is simplified to the Vertical Near-Side Perspective Projection. When georeferencing such a photo, the exact parameters of the projections are also needed. These parameters depend on the position of the viewpoint of the camera. Several hundreds of globe photos had to be georeferenced during the Virtual Globes Museum project, which made necessary to automatize the calculation of the projection parameters. The author developed a program for this task which uses the Nelder-Mead Method in order to find the optimum parameters when a set of control points are given as input. The Nelder-Mead method is a numerical algorithm for minimizing a function in a many-dimensional space. The function in the present application is the average error of the control points calculated from the actual values of parameters. The parameters are the geographical coordinates of the projection centre, the image coordinates of the same point, the rotation of the projection, the height of the perspective point and the scale of the photo (calculated in pixels/km). The program reads the Global Mappers Ground Control Point (.GCP) file format as input and creates projection description files (.PRJ) for the same software. The initial values of the geographical coordinates of the projection centre are calculated as the average of the control points, while the other parameters are set to experimental values which represent the most common circumstances of taking a globe photograph. The algorithm runs until the change of the parameters sinks below a pre-defined limit. The minimum search can be refined by using the previous result parameter set as new initial values. This paper introduces the calculation mechanism and examples of the usage. Other possible other usages of the method are also discussed.

Effects of Mead Wort Heat Treatment on the Mead Fermentation Process and Antioxidant Activity.

PubMed

Czabaj, Sławomir; Kawa-Rygielska, Joanna; Kucharska, Alicja Z; Kliks, Jarosław

2017-05-14

The effects of mead wort heat treatment on the mead fermentation process and antioxidant activity were tested. The experiment was conducted with the use of two different honeys (multiflorous and honeydew) collected from the Lower Silesia region (Poland). Heat treatment was performed with the use of a traditional technique (gently boiling), the more commonly used pasteurization, and without heat treatment (control). During the experiment fermentation dynamics were monitored using high performance liquid chromatography with refractive index detection (HPLC-RID). Total antioxidant capacity (TAC) and total phenolic content (TPC) were estimated for worts and meads using UV/Vis spectrophotometric analysis. The formation of 5-hydroxymethylfurfural (HMF) was monitored by HPLC analyses. Heat treatment had a great impact on the final antioxidant capacity of meads.

Numerical simulations of detonation propagation in gaseous fuel-air mixtures

NASA Astrophysics Data System (ADS)

Honhar, Praveen; Kaplan, Carolyn; Houim, Ryan; Oran, Elaine

2017-11-01

Unsteady multidimensional numerical simulations of detonation propagation and survival in mixtures of fuel (hydrogen or methane) diluted with air were carried out with a fully compressible Navier-Stokes solver using a simplified chemical-diffusive model (CDM). The CDM was derived using a genetic algorithm combined with the Nelder-Mead optimization algorithm and reproduces physically correct laminar flame and detonation properties. Cases studied are overdriven detonations propagating through confined mediums, with or without gradients in composition. Results from simulations confirm that the survival of the detonation depends on the channel heights. In addition, the simulations show that the propagation of the detonation waves depends on the steepness in composition gradients.

A Composite Algorithm for Mixed Integer Constrained Nonlinear Optimization.

DTIC Science & Technology

1980-01-01

de Silva [141, and Weisman and Wood [76). A particular direct search algorithm, the simplex method, has been cited for having the potential for...spaced discrete points on a line which makes the direction suitable for an efficient integer search technique based on Fibonacci numbers. Two...defined by a subset of variables. The complex algorithm is particularly well suited for this subspace search for two reasons. First, the complex method

G. H. Mead in the history of sociological ideas.

PubMed

da Silva, Filipe Carreira

2006-01-01

My aim is to discuss the history of the reception of George Herbert Mead's ideas in sociology. After discussing the methodological debate between presentism and historicism, I address the interpretations of those responsible for Mead's inclusion in the sociological canon: Herbert Blumer, Jürgen Habermas, and Hans Joas. In the concluding section, I assess these reconstructions of Mead's thought and suggest an alternative more consistent with my initial methodological remarks. In particular, I advocate a reconstruction of Mead's ideas that apprehends simultaneously its evolution over time and its thematic breadth. Such a historically minded reconstruction can be not only a useful corrective to possible anachronisms incurred by contemporary social theorists, but also a fruitful resource for their theory-building endeavors. Only then can meaningful and enriching dialogue with Mead begin. Copyright 2006 Wiley Periodicals, Inc.

Physically Based Modeling and Simulation with Dynamic Spherical Volumetric Simplex Splines

PubMed Central

Tan, Yunhao; Hua, Jing; Qin, Hong

2009-01-01

In this paper, we present a novel computational modeling and simulation framework based on dynamic spherical volumetric simplex splines. The framework can handle the modeling and simulation of genus-zero objects with real physical properties. In this framework, we first develop an accurate and efficient algorithm to reconstruct the high-fidelity digital model of a real-world object with spherical volumetric simplex splines which can represent with accuracy geometric, material, and other properties of the object simultaneously. With the tight coupling of Lagrangian mechanics, the dynamic volumetric simplex splines representing the object can accurately simulate its physical behavior because it can unify the geometric and material properties in the simulation. The visualization can be directly computed from the object’s geometric or physical representation based on the dynamic spherical volumetric simplex splines during simulation without interpolation or resampling. We have applied the framework for biomechanic simulation of brain deformations, such as brain shifting during the surgery and brain injury under blunt impact. We have compared our simulation results with the ground truth obtained through intra-operative magnetic resonance imaging and the real biomechanic experiments. The evaluations demonstrate the excellent performance of our new technique. PMID:20161636

Development of a Compound Optimization Approach Based on Imperialist Competitive Algorithm

NASA Astrophysics Data System (ADS)

Wang, Qimei; Yang, Zhihong; Wang, Yong

In this paper, an improved novel approach is developed for the imperialist competitive algorithm to achieve a greater performance. The Nelder-Meand simplex method is applied to execute alternately with the original procedures of the algorithm. The approach is tested on twelve widely-used benchmark functions and is also compared with other relative studies. It is shown that the proposed approach has a faster convergence rate, better search ability, and higher stability than the original algorithm and other relative methods.

Environmental Assessment and Finding of No Significant Impact: Western's Hoover Dam Bypass Project Phase II (Double-Circuiting a Portion of the Hoover-Mead No.5 and No.7 230-kV Transmission Lines with the Henderson-Mead No.1 230-kV Transmission Line, Clark County, Nevada)

DOE Office of Scientific and Technical Information (OSTI.GOV)

N /A

2003-10-27

The U.S. Highway 93 (U.S. 93) Hoover Dam Bypass Project calls for the U.S. Department of Energy (DOE) Western Area Power Administration (Western) to remove its Arizona and Nevada (A&N) Switchyard. As a result of this action, Western must reconfigure its existing electrical transmission system in the Hoover Dam area. Western proposes to double-circuit a portion of the Hoover-Mead No.5 and No.7 230-kV Transmission Lines with the Henderson-Mead No.1 Transmission Line (see Figure 1-1). Double-circuiting is the placement of two separate electrical circuits, typically in the form of three separate conductors or bundles of conductors, on the same set ofmore » transmission line structures. The old Henderson-Hoover 230-kV Transmission Line would become the new Henderson-Mead No.1 and would extend approximately eight miles to connect with the Mead Substation. Western owns, operates, and maintains the Hoover-Mead No.5 and No.7, and Henderson-Hoover electrical power transmission lines. Additionally, approximately 0.25 miles of new right-of-way (ROW) would be needed for the Henderson-Mead No.1 when it transfers from double-circuiting with the Hoover-Mead No.7 to the Hoover-Mead No.5 at the Boulder City Tap. The proposed project would also involve a new transmission line ROW and structures where the Henderson-Mead No.1 will split from the Hoover-Mead No.5 and enter the northeast corner of the Mead Substation. Lastly, Western has proposed adding fiber optic overhead ground wire from the Hoover Power Plant to the Mead Substation on to the Henderson-Mead No.1, Hoover-Mead No.5 and No.7 Transmission Lines. The proposed project includes replacing existing transmission line tower structures, installing new structures, and adding new electrical conductors and fiber optic cables. As a consequence of these activities, ground disturbance may result from grading areas for structure placement, constructing new roads, improving existing roads for vehicle and equipment access, and from installing structures, conductors, and fiber optic cables. Project construction activities would be conducted within the existing 200-foot transmission line ROW and 50-foot access road ROW, although new spur access roads could occur outside of existing ROWs. As lead Federal agency for this action under National Environmental Policy Act (NEPA), Western must ensure that adverse environmental effects on Federal and non-Federal lands and resources are avoided or minimized. This Environmental Assessment (EA) is intended to be a concise public document that assesses the probable and known impacts to the environment from Western's Proposed Action and alternatives, and reaches a conclusion about the significance of the impacts. This EA was prepared in compliance with NEPA regulations published by the Council on Environmental Quality (40 CFR 1500-1508) and implementing procedures of the Department of Energy (10 CFR 1021).« less

Lake Mead, NV

NASA Technical Reports Server (NTRS)

1982-01-01

Lake Mead, Nevada, (36.0N, 114.5E) where the water from the Colorado River empties after it's 273 mile journey through the Grand Canyon of Arizona is the subject of this photo. Other features of interest are Hoover Dam on the south shore of Lake Mead where cheap hydroelectric power is secondary to the water resources made available in this northern desert region and the resort city of Las Vegas, just to the west of Lake Mead.

Generating High-Resolution Lake Bathymetry over Lake Mead using the ICESat-2 Airborne Simulator

NASA Astrophysics Data System (ADS)

Li, Y.; Gao, H.; Jasinski, M. F.; Zhang, S.; Stoll, J.

2017-12-01

Precise lake bathymetry (i.e., elevation/contour) mapping is essential for optimal decision making in water resources management. Although the advancement of remote sensing has made it possible to monitor global reservoirs from space, most of the existing studies focus on estimating the elevation, area, and storage of reservoirs—and not on estimating the bathymetry. This limitation is attributed to the low spatial resolution of satellite altimeters. With the significant enhancement of ICESat-2—the Ice, Cloud & Land Elevation Satellite #2, which is scheduled to launch in 2018—producing satellite-based bathymetry becomes feasible. Here we present a pilot study for deriving the bathymetry of Lake Mead by combining Landsat area estimations with airborne elevation data using the prototype of ICESat-2—the Multiple Altimeter Beam Experimental Lidar (MABEL). First, an ISODATA classifier was adopted to extract the lake area from Landsat images during the period from 1982 to 2017. Then the lake area classifications were paired with MABEL elevations to establish an Area-Elevation (AE) relationship, which in turn was applied to the classification contour map to obtain the bathymetry. Finally, the Lake Mead bathymetry image was embedded onto the Shuttle Radar Topography Mission (SRTM) Digital Elevation Model (DEM), to replace the existing constant values. Validation against sediment survey data indicates that the bathymetry derived from this study is reliable. This algorithm has the potential for generating global lake bathymetry when ICESat-2 data become available after next year's launch.

A synthesis of aquatic science for management of Lakes Mead and Mohave

USGS Publications Warehouse

Rosen, Michael R.; Turner, Kent; Goodbred, Steven L.; Miller, Jennell M.

2012-01-01

Lakes Mead and Mohave, which are the centerpieces of Lake Mead National Recreation Area, provide many significant benefits that have made the modern development of the Southwestern United States possible. Lake Mead is the largest reservoir by volume in the nation and it supplies critical storage of water supplies for more than 25 million people in three Western States (California, Arizona, and Nevada). Storage within Lake Mead supplies drinking water and the hydropower to provide electricity for major cities including Las Vegas, Phoenix, Los Angeles, Tucson, and San Diego, and irrigation of more than 2.5 million acres of croplands. Lake Mead is arguably the most important reservoir in the nation because of its size and the services it delivers to the Western United States. This Circular includes seven chapters. Chapter 1 provides a short summary of the overall findings and management implications for Lakes Mead and Mohave that can be used to guide the reader through the rest of the Circular. Chapter 2 introduces the environmental setting and characteristics of Lakes Mead and Mohave and provides a brief management context of the lakes within the Colorado River system as well as overviews of the geological bedrock and sediment accumulations of the lakes. Chapter 3 contains summaries of the operational and hydrologic characteristics of Lakes Mead and Mohave. Chapter 4 provides information on water quality, including discussion on the monitoring of contaminants and sediments within the reservoirs. Chapter 5 describes aquatic biota and wildlife, including food-web dynamics, plankton, invertebrates, fish, aquatic birds, and aquatic vegetation. Chapter 6 outlines threats and stressors to the health of Lake Mead aquatic ecosystems that include a range of environmental contaminants, invasive species, and climate change. Chapter 7 provides a more detailed summary of overall findings that are presented in Chapter 1; and it contains a more detailed discussion on associated management implications, additional research, and monitoring needs.

A method of minimum volume simplex analysis constrained unmixing for hyperspectral image

NASA Astrophysics Data System (ADS)

Zou, Jinlin; Lan, Jinhui; Zeng, Yiliang; Wu, Hongtao

2017-07-01

The signal recorded by a low resolution hyperspectral remote sensor from a given pixel, letting alone the effects of the complex terrain, is a mixture of substances. To improve the accuracy of classification and sub-pixel object detection, hyperspectral unmixing(HU) is a frontier-line in remote sensing area. Unmixing algorithm based on geometric has become popular since the hyperspectral image possesses abundant spectral information and the mixed model is easy to understand. However, most of the algorithms are based on pure pixel assumption, and since the non-linear mixed model is complex, it is hard to obtain the optimal endmembers especially under a highly mixed spectral data. To provide a simple but accurate method, we propose a minimum volume simplex analysis constrained (MVSAC) unmixing algorithm. The proposed approach combines the algebraic constraints that are inherent to the convex minimum volume with abundance soft constraint. While considering abundance fraction, we can obtain the pure endmember set and abundance fraction correspondingly, and the final unmixing result is closer to reality and has better accuracy. We illustrate the performance of the proposed algorithm in unmixing simulated data and real hyperspectral data, and the result indicates that the proposed method can obtain the distinct signatures correctly without redundant endmember and yields much better performance than the pure pixel based algorithm.

Data association approaches in bearings-only multi-target tracking

NASA Astrophysics Data System (ADS)

Xu, Benlian; Wang, Zhiquan

2008-03-01

According to requirements of time computation complexity and correctness of data association of the multi-target tracking, two algorithms are suggested in this paper. The proposed Algorithm 1 is developed from the modified version of dual Simplex method, and it has the advantage of direct and explicit form of the optimal solution. The Algorithm 2 is based on the idea of Algorithm 1 and rotational sort method, it combines not only advantages of Algorithm 1, but also reduces the computational burden, whose complexity is only 1/ N times that of Algorithm 1. Finally, numerical analyses are carried out to evaluate the performance of the two data association algorithms.

Ames Women's Influence Network (WIN) Hidden Figures talk with "Computers" Carolyn Hofstetter and Carol Mead co-sponsored by the AAAG

NASA Image and Video Library

2017-02-01

Ames Women's Influence Network (WIN) Hidden Figures talk with "Computers" Carolyn Hofstetter and Carol Mead co-sponsored by the AAAG. Left to right Computers Carolyn Hofstetter, Carol Mead and Jack Boyd

Accommodation of practical constraints by a linear programming jet select. [for Space Shuttle

NASA Technical Reports Server (NTRS)

Bergmann, E.; Weiler, P.

1983-01-01

An experimental spacecraft control system will be incorporated into the Space Shuttle flight software and exercised during a forthcoming mission to evaluate its performance and handling qualities. The control system incorporates a 'phase space' control law to generate rate change requests and a linear programming jet select to compute jet firings. Posed as a linear programming problem, jet selection must represent the rate change request as a linear combination of jet acceleration vectors where the coefficients are the jet firing times, while minimizing the fuel expended in satisfying that request. This problem is solved in real time using a revised Simplex algorithm. In order to implement the jet selection algorithm in the Shuttle flight control computer, it was modified to accommodate certain practical features of the Shuttle such as limited computer throughput, lengthy firing times, and a large number of control jets. To the authors' knowledge, this is the first such application of linear programming. It was made possible by careful consideration of the jet selection problem in terms of the properties of linear programming and the Simplex algorithm. These modifications to the jet select algorithm may by useful for the design of reaction controlled spacecraft.

A tutorial description of an interior point method and its applications to security-constrained economic dispatch

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vargas, L.S.; Quintana, V.H.; Vannelli, A.

This paper deals with the use of Successive Linear Programming (SLP) for the solution of the Security-Constrained Economic Dispatch (SCED) problem. The authors tutorially describe an Interior Point Method (IPM) for the solution of Linear Programming (LP) problems, discussing important implementation issues that really make this method far superior to the simplex method. A study of the convergence of the SLP technique and a practical criterion to avoid oscillatory behavior in the iteration process are also proposed. A comparison of the proposed method with an efficient simplex code (MINOS) is carried out by solving SCED problems on two standard IEEEmore » systems. The results show that the interior point technique is reliable, accurate and more than two times faster than the simplex algorithm.« less

Ames Women's Influence Network (WIN) Hidden Figures talk with "Computers" Carolyn Hofstetter and Carol Mead co-sponsored by the AAAG

NASA Image and Video Library

2017-02-01

Ames Women's Influence Network (WIN) Hidden Figures talk with "Computers" Carolyn Hofstetter and Carol Mead co-sponsored by the AAAG. Left to right Barbara Miller, Ames EEO, Computers Carolyn Hofstetter and Carol Mead

Ames Women's Influence Network (WIN) Hidden Figures talk with "Computers" Carolyn Hofstetter and Carol Mead co-sponsored by the AAAG

NASA Image and Video Library

2017-02-01

Ames Women's Influence Network (WIN) Hidden Figures talk with "Computers" Carolyn Hofstetter and Carol Mead co-sponsored by the AAAG.. Left to right Barbara Miller, Ames EEO, Computers Carolyn Hofstetter and Carol Mead

76 FR 75917 - Post Office Closing

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-05

... POSTAL REGULATORY COMMISSION [Docket No. A2012-63; Order No. 1004] Post Office Closing AGENCY... the closing of the Fort Meade, South Dakota post office has been filed. It identifies preliminary... Postal Service's determination to close the Fort Meade post office in Fort Meade, South Dakota. The...

Fractal Landscape Algorithms for Environmental Simulations

NASA Astrophysics Data System (ADS)

Mao, H.; Moran, S.

2014-12-01

Natural science and geographical research are now able to take advantage of environmental simulations that more accurately test experimental hypotheses, resulting in deeper understanding. Experiments affected by the natural environment can benefit from 3D landscape simulations capable of simulating a variety of terrains and environmental phenomena. Such simulations can employ random terrain generation algorithms that dynamically simulate environments to test specific models against a variety of factors. Through the use of noise functions such as Perlin noise, Simplex noise, and diamond square algorithms, computers can generate simulations that model a variety of landscapes and ecosystems. This study shows how these algorithms work together to create realistic landscapes. By seeding values into the diamond square algorithm, one can control the shape of landscape. Perlin noise and Simplex noise are also used to simulate moisture and temperature. The smooth gradient created by coherent noise allows more realistic landscapes to be simulated. Terrain generation algorithms can be used in environmental studies and physics simulations. Potential studies that would benefit from simulations include the geophysical impact of flash floods or drought on a particular region and regional impacts on low lying area due to global warming and rising sea levels. Furthermore, terrain generation algorithms also serve as aesthetic tools to display landscapes (Google Earth), and simulate planetary landscapes. Hence, it can be used as a tool to assist science education. Algorithms used to generate these natural phenomena provide scientists a different approach in analyzing our world. The random algorithms used in terrain generation not only contribute to the generating the terrains themselves, but are also capable of simulating weather patterns.

SMV⊥: Simplex of maximal volume based upon the Gram-Schmidt process

NASA Astrophysics Data System (ADS)

Salazar-Vazquez, Jairo; Mendez-Vazquez, Andres

2015-10-01

In recent years, different algorithms for Hyperspectral Image (HI) analysis have been introduced. The high spectral resolution of these images allows to develop different algorithms for target detection, material mapping, and material identification for applications in Agriculture, Security and Defense, Industry, etc. Therefore, from the computer science's point of view, there is fertile field of research for improving and developing algorithms in HI analysis. In some applications, the spectral pixels of a HI can be classified using laboratory spectral signatures. Nevertheless, for many others, there is no enough available prior information or spectral signatures, making any analysis a difficult task. One of the most popular algorithms for the HI analysis is the N-FINDR because it is easy to understand and provides a way to unmix the original HI in the respective material compositions. The N-FINDR is computationally expensive and its performance depends on a random initialization process. This paper proposes a novel idea to reduce the complexity of the N-FINDR by implementing a bottom-up approach based in an observation from linear algebra and the use of the Gram-Schmidt process. Therefore, the Simplex of Maximal Volume Perpendicular (SMV⊥) algorithm is proposed for fast endmember extraction in hyperspectral imagery. This novel algorithm has complexity O(n) with respect to the number of pixels. In addition, the evidence shows that SMV⊥ calculates a bigger volume, and has lower computational time complexity than other poular algorithms on synthetic and real scenarios.

A Simulation Optimization Approach to Epidemic Forecasting

PubMed Central

Nsoesie, Elaine O.; Beckman, Richard J.; Shashaani, Sara; Nagaraj, Kalyani S.; Marathe, Madhav V.

2013-01-01

Reliable forecasts of influenza can aid in the control of both seasonal and pandemic outbreaks. We introduce a simulation optimization (SIMOP) approach for forecasting the influenza epidemic curve. This study represents the final step of a project aimed at using a combination of simulation, classification, statistical and optimization techniques to forecast the epidemic curve and infer underlying model parameters during an influenza outbreak. The SIMOP procedure combines an individual-based model and the Nelder-Mead simplex optimization method. The method is used to forecast epidemics simulated over synthetic social networks representing Montgomery County in Virginia, Miami, Seattle and surrounding metropolitan regions. The results are presented for the first four weeks. Depending on the synthetic network, the peak time could be predicted within a 95% CI as early as seven weeks before the actual peak. The peak infected and total infected were also accurately forecasted for Montgomery County in Virginia within the forecasting period. Forecasting of the epidemic curve for both seasonal and pandemic influenza outbreaks is a complex problem, however this is a preliminary step and the results suggest that more can be achieved in this area. PMID:23826222

A Simulation Optimization Approach to Epidemic Forecasting.

PubMed

Nsoesie, Elaine O; Beckman, Richard J; Shashaani, Sara; Nagaraj, Kalyani S; Marathe, Madhav V

2013-01-01

Reliable forecasts of influenza can aid in the control of both seasonal and pandemic outbreaks. We introduce a simulation optimization (SIMOP) approach for forecasting the influenza epidemic curve. This study represents the final step of a project aimed at using a combination of simulation, classification, statistical and optimization techniques to forecast the epidemic curve and infer underlying model parameters during an influenza outbreak. The SIMOP procedure combines an individual-based model and the Nelder-Mead simplex optimization method. The method is used to forecast epidemics simulated over synthetic social networks representing Montgomery County in Virginia, Miami, Seattle and surrounding metropolitan regions. The results are presented for the first four weeks. Depending on the synthetic network, the peak time could be predicted within a 95% CI as early as seven weeks before the actual peak. The peak infected and total infected were also accurately forecasted for Montgomery County in Virginia within the forecasting period. Forecasting of the epidemic curve for both seasonal and pandemic influenza outbreaks is a complex problem, however this is a preliminary step and the results suggest that more can be achieved in this area.

Interpolation Hermite Polynomials For Finite Element Method

NASA Astrophysics Data System (ADS)

Gusev, Alexander; Vinitsky, Sergue; Chuluunbaatar, Ochbadrakh; Chuluunbaatar, Galmandakh; Gerdt, Vladimir; Derbov, Vladimir; Góźdź, Andrzej; Krassovitskiy, Pavel

2018-02-01

We describe a new algorithm for analytic calculation of high-order Hermite interpolation polynomials of the simplex and give their classification. A typical example of triangle element, to be built in high accuracy finite element schemes, is given.

Ames Women's Influence Network (WIN) Hidden Figures talk with "Computers" Carolyn Hofstetter and Carol Mead co-sponsored by the AAAG

NASA Image and Video Library

2017-02-01

Ames Women's Influence Network (WIN) Hidden Figures talk with "Computers" Carolyn Hofstetter and Carol Mead co-sponsored by the AAAG. Jack Boyd talk of working in the same 6ft w.t. group as Carol Mead.

George Herbert Mead's Contribution to the Philosophy of American Education.

ERIC Educational Resources Information Center

Renger, Paul, III

1980-01-01

George Herbert Mead's general philsophy showed that he regarded the development of distinctively human behavior as essentially the result of an individual's meaningful participation in the social process of the community to which he belongs. Mead believed that education was a social process involving the meaningful interaction and communication…

Lake Mead, NV

NASA Technical Reports Server (NTRS)

1973-01-01

Lake Mead, Nevada, (36.0N, 114.5E) where the water from the Colorado River empties after it's 273 mile journey through the Grand Canyon of Arizona is the subject of this photo. Other features of interest are Hoover Dam on the south shore of Lake Mead where cheap hydroelectric power is secondary to the water resources made available in this northern desert region and the resort city of Las Vegas, just to the west of Lake Mead. In this harsh desert environment, color infrared photography readily penetrates haze, detects and portrays vegetation as shades of red.

Patriot/Medium Extended Air Defense System Combined Aggregate Program (Patriot/MEADS CAP)

DTIC Science & Technology

2013-12-01

States, Germany, and Italy to replace the U.S. Patriot air defense systems, Patriot and Hawk systems in Germany, and the Nike system in Italy. The MEADS...Appropriation: RDT&E Contract Name Design & Development Contractor MEADS International Inc . Contractor Location 5600 W Sand Lake Road Orlando, FL 32819

Ames Women's Influence Network (WIN) Hidden Figures talk with "Computers" Carolyn Hofstetter and Carol Mead co-sponsored by the AAAG

NASA Image and Video Library

2017-02-01

Ames Women's Influence Network (WIN) Hidden Figures talk with "Computers" Carolyn Hofstetter and Carol Mead co-sponsored by the AAAG. Left to right Barbara Miller, Ames EEO, Computers Carolyn Hoffstetter and Carol Mead, talking to Carolyn Hofstetter is Arlene Spencer

A Social Behaviorist Interpretation of the Meadian "I."

ERIC Educational Resources Information Center

Lewis, J. David

1979-01-01

Argues that the two most common interpretations of the Meadian "I" in George Herbert Mead's theory of social self have failed to place the concept within the context of Mead's philosophy of social behaviorism. Stresses also that Mead's theory of social behaviorist interpretation is applicable to sociological inquiry when it is properly…

Educating Communal Agents: Building on the Perspectivism of G.H. Mead

ERIC Educational Resources Information Center

Martin, Jack

2007-01-01

In their search for more communal forms of agency that might guide education, contemporary educational psychologists have mostly neglected the theorizing of George Herbert Mead. In this essay, Jack Martin aims to remedy such oversight by interpreting Mead's social-psychological and educational theorizing of selfhood and agency through the lenses…

The Texture of Educational Inquiry: An Exploration of George Herbert Mead's Concept of the Scientific.

ERIC Educational Resources Information Center

Franzosa, Susan Douglas

1984-01-01

Explores the implications of Mead's philosophic social psychology for current disputes concerning the nature of the scientific in educational studies. Mead's contextualization of the knower and the known are found to be compatible with a contemporary critique of positivist paradigms and a critical reconceptualization of educational inquiry.…

75 FR 427 - Notice of Continuation of Visitor Services

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-05

... under 36 CFR 51.23. Under the provisions of current concession contracts and pending the completion of... & Golden Gate National Recreation William Hontalas. Area. LAME001-73 Rex G. Maughan & Ruth G. Maughan Area...... Lake Mead National Recreation Area LAME002-82 Lake Mead RV Village, LLC Lake Mead National Recreation...

Incapacity of Response to Disulfide-Reducing Agent in Triton X-100-Treated Oocytes of Starfish, Asterina pectinifera

NASA Astrophysics Data System (ADS)

Mita, Masatoshi

2005-04-01

Resumption of meiosis in starfish oocytes is induced by the natural maturation-inducing hormone, 1-methyladenine (1-MeAde). Oocyte maturation is also induced by the disulfide-reducing agent, dithiothreitol (DTT). Previous studies have shown that 1-MeAde controls meiosis by interacting with its receptors, which are located exclusively on oocyte plasma membrane. However, little is known about the mechanism of oocyte maturation induced by DTT. Thus, this study examined whether DTT interacts with 1-MeAde receptors to induce oocyte maturation. When oocytes were treated with Triton X-100, they failed to respond to 1-MeAde and DTT. Although the Triton X-100-treated oocytes recovered the capacity to respond to 1-MeAde during incubation in seawater, they remained unresponsive to DTT during seawater incubations. These results suggest that DTT does not interact with 1-MeAde receptors to induce oocyte maturation in starfish. It is possible that a protein essential for mediating DTT-induced maturation is eliminated from the oocytes surface following Triton X-100 treatment.

Analysis of iodide and iodate in Lake Mead, Nevada using a headspace derivatization gas chromatography-mass spectrometry.

PubMed

Dorman, James W; Steinberg, Spencer M

2010-02-01

We report here a derivatization headspace method for the analysis of inorganic iodine in water. Samples from Lake Mead, the Las Vegas Wash, and from Las Vegas tap water were examined. Lake Mead and the Las Vegas Wash contained a mixture of both iodide and iodate. The average concentration of total inorganic iodine (TII) for Lake Mead was approximately 90 nM with an iodide-to-iodate ratio of approximately 1. The TII concentration (approximately 160 nM) and the ratio of iodide to iodate were higher for the Las Vegas Wash (approximately 2). The TII concentration for tap water was close to that of Lake Mead (approximately 90 nM); however, tap water contained no detectable iodide as a result of ozonation and chlorine treatment which converts all of the iodide to iodate.

Lake Mead, NV

NASA Image and Video Library

1973-06-22

SL2-03-192 (22 June 1973) --- Lake Mead, Nevada, (36.0N, 114.5E) where the water from the Colorado River empties after it's 273 mile journey through the Grand Canyon of Arizona is the subject of this photo. Other features of interest are Hoover Dam on the south shore of Lake Mead where cheap hydroelectric power is secondary to the water resources made available in this northern desert region and the resort city of Las Vegas, just to the west of Lake Mead. In this harsh desert environment, color infrared photography readily penetrates haze, detects and portrays vegetation as shades of red. Photo credit: NASA

Principal facts for gravity stations and physical property measurements in the Lake Mead 30' by 60' quadrangle, Nevada and Arizona

USGS Publications Warehouse

Langenheim, V.E.; Davidson, J.G.; Anderson, M.L.; Blank, H.R.

1999-01-01

The U.S. Geological Survey (USGS) collected 811 gravity stations on the Lake Mead 30' by 60' quadrangle from October, 1997 to September, 1999. These data were collected in support of geologic mapping of the Lake Mead quadrangle. In addition to these new data, gravity stations were compiled from a number of sources. These stations were reprocessed according to the reduction method described below and used for the new data. Density and magnetic susceptibility measurements were also performed on more than 250 rock samples. The Lake Mead quadrangle ranges from 360 to 360 30' north latitude and from 114° to 115° west longitude. It spans most of Lake Mead (see index map, below), the largest manmade lake in the United States, and includes most of the Lake Mead National Recreation Area. Its geology is very complex; Mesozoic thrust faults are exposed in the Muddy Mountains, Precambrian crystalline basement rocks are exhumed in tilted fault blocks near Gold Butte, extensive Tertiary volcanism is evident in the Black Mountains, and strike-slip faults of the right-lateral Las Vegas Valley shear zone and the left-lateral Lake Mead fault system meet near the Gale Hills. These gravity data and physical property measurements will aid in the 3-dimensional characterization of structure and stratigraphy in the quadrangle as part of the Las Vegas Urban Corridor mapping project.

33 CFR 162.220 - Hoover Dam, Lake Mead, and Lake Mohave (Colorado River), Ariz.-Nev.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Mohave (Colorado River), Ariz.-Nev. 162.220 Section 162.220 Navigation and Navigable Waters COAST GUARD... REGULATIONS § 162.220 Hoover Dam, Lake Mead, and Lake Mohave (Colorado River), Ariz.-Nev. (a) Lake Mead and... the axis of Hoover Dam and that portion of Lake Mohave (Colorado River) extending 4,500 feet...

Influence and canonical supremacy: an analysis of how George Herbert Mead demoted Charles Horton Cooley in the sociological canon.

PubMed

Jacobs, Glenn

2009-01-01

This analysis assesses the factors underlying Charles Horton Cooley's place in the sociological canon as they relate to George Herbert Mead's puzzling diatribe-echoed in secondary accounts-against Cooley's social psychology and view of the self published scarcely a year after his death. The illocutionary act of publishing his critique stands as an effort to project the image of Mead's intellectual self and enhance his standing among sociologists within and outside the orbit of the University of Chicago. It expressed Mead's ambivalence toward his precursor Cooley, whose influence he never fully acknowledged. In addition, it typifies the contending fractal distinctions of the scientifically discursive versus literary styles of Mead and Cooley, who both founded the interpretive sociological tradition. The contrasting styles and attitudes toward writing of the two figures are discussed, and their implications for the problems of scale that have stymied the symbolic interactionist tradition are explored.

A sociohistorical examination of George Herbert Mead's approach to science education.

PubMed

Edwards, Michelle L

2016-07-01

Although George Herbert Mead is widely known for his social psychological work, his views on science education also represent a significant, yet sometimes overlooked contribution. In a speech delivered in March 1906 entitled "The Teaching of Science in College," Mead calls for cultural courses on the sciences, such as sociology of science or history of science courses, to increase the relevancy of natural and physical science courses for high school and university students. These views reflect Mead's perspective on a number of traditional dualisms, including objectivity versus subjectivity and the social sciences versus natural and physical sciences. Taking a sociohistorical outlook, I identify the context behind Mead's approach to science education, which includes three major influences: (1) German intellectual thought and the Methodenstreit debate, (2) pragmatism and Darwin's theory of evolution, and (3) social reform efforts in Chicago and the General Science Movement. © The Author(s) 2014.

George Herbert Mead's Lecture on Philosophy of Education at the University of Chicago (1910-1911).

ERIC Educational Resources Information Center

Biesta, Gert J. J.

This paper recounts the influence of two of the great educational philosophers of this century, John Dewey and George Herbert Mead. Both men came to the University of Chicago from teaching at the University of Michigan. The men were life-long personal friends and professional colleagues. Although Mead published little during his life, his…

Getting an "Inside": The Role of Objects in Mead's Theory of Self.

ERIC Educational Resources Information Center

McCarthy, E. Doyle

The paper examines George Herbert Mead's account of the individual's relation to the physical world. Mead (1863-1931) taught social psychology and philosophy at the University of Chicago from 1893-1931 and is best known for his theory of self. This theory maintains that the self is formed in a particular historical context and that it includes…

Deterministic and stochastic algorithms for resolving the flow fields in ducts and networks using energy minimization

NASA Astrophysics Data System (ADS)

Sochi, Taha

2016-09-01

Several deterministic and stochastic multi-variable global optimization algorithms (Conjugate Gradient, Nelder-Mead, Quasi-Newton and global) are investigated in conjunction with energy minimization principle to resolve the pressure and volumetric flow rate fields in single ducts and networks of interconnected ducts. The algorithms are tested with seven types of fluid: Newtonian, power law, Bingham, Herschel-Bulkley, Ellis, Ree-Eyring and Casson. The results obtained from all those algorithms for all these types of fluid agree very well with the analytically derived solutions as obtained from the traditional methods which are based on the conservation principles and fluid constitutive relations. The results confirm and generalize the findings of our previous investigations that the energy minimization principle is at the heart of the flow dynamics systems. The investigation also enriches the methods of computational fluid dynamics for solving the flow fields in tubes and networks for various types of Newtonian and non-Newtonian fluids.

Directed Bee Colony Optimization Algorithm to Solve the Nurse Rostering Problem.

PubMed

Rajeswari, M; Amudhavel, J; Pothula, Sujatha; Dhavachelvan, P

2017-01-01

The Nurse Rostering Problem is an NP-hard combinatorial optimization, scheduling problem for assigning a set of nurses to shifts per day by considering both hard and soft constraints. A novel metaheuristic technique is required for solving Nurse Rostering Problem (NRP). This work proposes a metaheuristic technique called Directed Bee Colony Optimization Algorithm using the Modified Nelder-Mead Method for solving the NRP. To solve the NRP, the authors used a multiobjective mathematical programming model and proposed a methodology for the adaptation of a Multiobjective Directed Bee Colony Optimization (MODBCO). MODBCO is used successfully for solving the multiobjective problem of optimizing the scheduling problems. This MODBCO is an integration of deterministic local search, multiagent particle system environment, and honey bee decision-making process. The performance of the algorithm is assessed using the standard dataset INRC2010, and it reflects many real-world cases which vary in size and complexity. The experimental analysis uses statistical tools to show the uniqueness of the algorithm on assessment criteria.

Directed Bee Colony Optimization Algorithm to Solve the Nurse Rostering Problem

PubMed Central

Amudhavel, J.; Pothula, Sujatha; Dhavachelvan, P.

2017-01-01

The Nurse Rostering Problem is an NP-hard combinatorial optimization, scheduling problem for assigning a set of nurses to shifts per day by considering both hard and soft constraints. A novel metaheuristic technique is required for solving Nurse Rostering Problem (NRP). This work proposes a metaheuristic technique called Directed Bee Colony Optimization Algorithm using the Modified Nelder-Mead Method for solving the NRP. To solve the NRP, the authors used a multiobjective mathematical programming model and proposed a methodology for the adaptation of a Multiobjective Directed Bee Colony Optimization (MODBCO). MODBCO is used successfully for solving the multiobjective problem of optimizing the scheduling problems. This MODBCO is an integration of deterministic local search, multiagent particle system environment, and honey bee decision-making process. The performance of the algorithm is assessed using the standard dataset INRC2010, and it reflects many real-world cases which vary in size and complexity. The experimental analysis uses statistical tools to show the uniqueness of the algorithm on assessment criteria. PMID:28473849

Raccoon ecological management area: partnership between Forest Service research and Mead Corporation

Treesearch

Daniel Yaussy; Wayne Lashbrook; Walt Smith

1997-01-01

The Chief of the Forest Service and the Chief Executive Officer of Mead Corporation signed a Memorandum of Understating (MOU) that created the Raccoon Ecological Management Area (REMA). This MOU designated nearly 17,000 acres as a special area to be co-managed by Mead and the Forest Service. The REMA is a working forest that continues to produce timber and pulpwood for...

The Economic Costs of a Shrinking Lake Mead: a Spatial Hedonic Analysis

NASA Astrophysics Data System (ADS)

Singh, A.; Saphores, J. D.

2017-12-01

Persistent arid conditions and population growth in the Southwest have taken a toll on the Colorado River. This has led to substantial drawdowns of many water reservoirs around the Southwest, and especially of Lake Mead, which is Las Vegas' main source of drinking water. Due to its importance, Lake Mead has received a great deal of media attention about its "bathtub ring" and the exposure of rock that used to be underwater. Drops in water levels have caused some local marinas to close, thereby affecting the aesthetic and recreational value of Lake Mead, which is located in the country's largest National Recreation Area (NRA), and surrounded by protected land. Although a rich literature analyzes how water quality impacts real estate values, relatively few studies have examined how dropping water levels are capitalized in surrounding residential properties. In this context, the goal of this study is to quantify how Lake Mead's water level changes are reflected in changes in local property values, an important source of tax income for any community. Since Lake Mead is the primary attraction within its recreation area, we are also concerned with how this recreation area, which is a few miles southeast of Las Vegas, is capitalized in real estate values of the Las Vegas metropolitan area as few valuation studies have examined how proximity to national parks influences residential property value. We estimate spatial hedonic and geographically weighted regression models of single family residences to delineate the value of proximity to the Lake Mead NRA and to understand how this value changed with Lake Mead's water levels. Our explanatory variables include common structural characteristics, fixed effects to account for unobserved locally constant characteristics, and specific variables such as distance to the Las Vegas strip and to downtown casinos. Because the sharpest declines in Lake Mead water levels happened in 2010 (NASA, 2010) and winter 2016 saw an unexpected increases in water levels, we analyze home sales and variations in water levels from 2010 to the mid 2017.

Geometric convex cone volume analysis

NASA Astrophysics Data System (ADS)

Li, Hsiao-Chi; Chang, Chein-I.

2016-05-01

Convexity is a major concept used to design and develop endmember finding algorithms (EFAs). For abundance unconstrained techniques, Pixel Purity Index (PPI) and Automatic Target Generation Process (ATGP) which use Orthogonal Projection (OP) as a criterion, are commonly used method. For abundance partially constrained techniques, Convex Cone Analysis is generally preferred which makes use of convex cones to impose Abundance Non-negativity Constraint (ANC). For abundance fully constrained N-FINDR and Simplex Growing Algorithm (SGA) are most popular methods which use simplex volume as a criterion to impose ANC and Abundance Sum-to-one Constraint (ASC). This paper analyze an issue encountered in volume calculation with a hyperplane introduced to illustrate an idea of bounded convex cone. Geometric Convex Cone Volume Analysis (GCCVA) projects the boundary vectors of a convex cone orthogonally on a hyperplane to reduce the effect of background signatures and a geometric volume approach is applied to address the issue arose from calculating volume and further improve the performance of convex cone-based EFAs.

Data Retrieval Algorithm and Uncertainty Analysis for a Miniaturized, Laser Heterodyne Radiometer

NASA Astrophysics Data System (ADS)

Miller, J. H.; Melroy, H.; Wilson, E. L.; Clarke, G. B.

2013-12-01

In a collaboration between NASA Goddard Space Flight Center and George Washington University, a low-cost, surface instrument is being developed that can continuously monitor key carbon cycle gases in the atmospheric column: carbon dioxide (CO2) and methane (CH4). The instrument is based on a miniaturized, laser heterodyne radiometer (LHR) using near infrared (NIR) telecom lasers. Despite relatively weak absorption line strengths in this spectral region, spectrally-resolved atmospheric column absorptions for these two molecules fall in the range of 60-80% and thus sensitive and precise measurements of column concentrations are possible. Further, because the LHR technique has the potential for sub-Doppler spectral resolution, the possibility exists for interrogating line shapes to extract altitude profiles of the greenhouse gases. From late 2012 through 2013 the instrument was deployed for a variety of field measurements including at Park Falls, Wisconsin; Castle Airport near Atwater, California; and at the NOAA Mauna Loa Observatory in Hawaii. For each subsequent campaign, improvement in the figures of merit for the instrument (notably spectral sweep time and absorbance noise) has been observed. For the latter, the absorbance noise is approaching 0.002 optical density (OD) noise on a 1.8 OD signal. This presentation presents an overview of the measurement campaigns in the context of the data retrieval algorithm under development at GW for the calculation of column concentrations from them. For light transmission through the atmosphere, it is necessary to account for variation of pressure, temperature, composition, and refractive index through the atmosphere that are all functions of latitude, longitude, time of day, altitude, etc. In our initial work we began with coding developed under the LOWTRAN and MODTRAN programs by the AFOSR (and others). We also assumed temperature and pressure profiles from the 1976 US Standard Atmosphere and used the US Naval Observatory database for local zenith angle calculations to initialize path trajectory calculations. In our newest version of the retrieval algorithm, the Python programming language module PySolar is used for the path geometry calculations. For temperature, pressure, and humidity profiles with altitude we use the Modern-Era Retrospective Analysis for Research and Applications (MERRA) data that has been compiled every 6 hours. Spectral simulation is accomplished by integrating short-path segments along the trajectory using the SpecSyn spectral simulation suite developed at GW. Column concentrations are extracted by minimizing residuals between observed and modeled spectrum using the Nelder-Mead simplex algorithm as implemented in the SciPy Python module. We will also present an assessment of uncertainty in the reported concentrations from assumptions made in the meteorological data, LHR instrument and tracker noise, and radio frequency bandwidth and describe additional future goals in instrument development and deployment targets.

STS-64 Official Crew Portrait

NASA Technical Reports Server (NTRS)

1994-01-01

The crewmen assigned to the STS-64 mission include: Astronaut Richard N. Richards (center front), mission commander; L. Blaine Hammond Jr., (front left) pilot and Susan J. Helms (front right) mission specialist. On the back row, from left to right are: Mark C. Lee, Jerry M. Linenger and Carl J. Meade, all mission specialists. All but Lee and Meade are wearing launch and entry suits. Lee and Meade are wearing extravehicular activity units (EMU).

Homelessness in Modern Society: An Integration of Mead and Berger and Implications for a Paradigm of Mass Communication.

ERIC Educational Resources Information Center

Jones, Charlotte

George Herbert Mead's theory of mind, self, and society is synthesized in this paper, as is the extension of that basic theory by Peter Berger and Thomas Luckmann. The paper argues that Mead's functionalist perspective, while rich and internally consistent, is naive in that it lacks a theory of institutions, and it shows how Berger and Luckmann's…

A philosophical examination of Mead's pragmatist constructivism as a referent for adult science education

NASA Astrophysics Data System (ADS)

Furbish, Dean Russel

The purpose of this study is to examine pragmatist constructivism as a science education referent for adult learners. Specifically, this study seeks to determine whether George Herbert Mead's doctrine, which conflates pragmatist learning theory and philosophy of natural science, might facilitate (a) scientific concept acquisition, (b) learning scientific methods, and (c) preparation of learners for careers in science and science-related areas. A philosophical examination of Mead's doctrine in light of these three criteria has determined that pragmatist constructivism is not a viable science education referent for adult learners. Mead's pragmatist constructivism does not portray scientific knowledge or scientific methods as they are understood by practicing scientists themselves, that is, according to scientific realism. Thus, employment of pragmatist constructivism does not adequately prepare future practitioners for careers in science-related areas. Mead's metaphysics does not allow him to commit to the existence of the unobservable objects of science such as molecular cellulose or mosquito-borne malarial parasites. Mead's anti-realist metaphysics also affects his conception of scientific methods. Because Mead does not commit existentially to the unobservable objects of realist science, Mead's science does not seek to determine what causal role if any the hypothetical objects that scientists routinely posit while theorizing might play in observable phenomena. Instead, constructivist pragmatism promotes subjective epistemology and instrumental methods. The implication for learning science is that students are encouraged to derive scientific concepts based on a combination of personal experience and personal meaningfulness. Contrary to pragmatist constructivism, however, scientific concepts do not arise inductively from subjective experience driven by personal interests. The broader implication of this study for adult education is that the philosophically laden claims of constructivist learning theories need to be identified and assessed independently of any empirical support that these learning theories might enjoy. This in turn calls for educational experiences for graduate students of education that incorporate philosophical understanding such that future educators might be able to recognize and weigh the philosophically laden claims of adult learning theories.

LP and NLP decomposition without a master problem

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fuller, D.; Lan, B.

We describe a new algorithm for decomposition of linear programs and a class of convex nonlinear programs, together with theoretical properties and some test results. Its most striking feature is the absence of a master problem; the subproblems pass primal and dual proposals directly to one another. The algorithm is defined for multi-stage LPs or NLPs, in which the constraints link the current stage`s variables to earlier stages` variables. This problem class is general enough to include many problem structures that do not immediately suggest stages, such as block diagonal problems. The basic algorithmis derived for two-stage problems and extendedmore » to more than two stages through nested decomposition. The main theoretical result assures convergence, to within any preset tolerance of the optimal value, in a finite number of iterations. This asymptotic convergence result contrasts with the results of limited tests on LPs, in which the optimal solution is apparently found exactly, i.e., to machine accuracy, in a small number of iterations. The tests further suggest that for LPs, the new algorithm is faster than the simplex method applied to the whole problem, as long as the stages are linked loosely; that the speedup over the simpex method improves as the number of stages increases; and that the algorithm is more reliable than nested Dantzig-Wolfe or Benders` methods in its improvement over the simplex method.« less

View of Lake Mead and Las Vegas, Nevada area from Sklyab

NASA Technical Reports Server (NTRS)

1973-01-01

A vertical view of the Lake Mead and Las Vegas, Nevada area as photographed from Earth orbit by one of the six lenses of the Itek-furnished S190-A Multispectral Photographic Facility Experiment aboard the Skylab space station. Lake Mead is water of the Colorado River impounded by Hoover Dam. Most of the land in the picture is Nevada, however, a part of the northwest corner of Arizona can be seen.

An approach to unbiased subsample interpolation for motion tracking.

PubMed

McCormick, Matthew M; Varghese, Tomy

2013-04-01

Accurate subsample displacement estimation is necessary for ultrasound elastography because of the small deformations that occur and the subsequent application of a derivative operation on local displacements. Many of the commonly used subsample estimation techniques introduce significant bias errors. This article addresses a reduced bias approach to subsample displacement estimations that consists of a two-dimensional windowed-sinc interpolation with numerical optimization. It is shown that a Welch or Lanczos window with a Nelder-Mead simplex or regular-step gradient-descent optimization is well suited for this purpose. Little improvement results from a sinc window radius greater than four data samples. The strain signal-to-noise ratio (SNR) obtained in a uniformly elastic phantom is compared with other parabolic and cosine interpolation methods; it is found that the strain SNR ratio is improved over parabolic interpolation from 11.0 to 13.6 in the axial direction and 0.7 to 1.1 in the lateral direction for an applied 1% axial deformation. The improvement was most significant for small strains and displacement tracking in the lateral direction. This approach does not rely on special properties of the image or similarity function, which is demonstrated by its effectiveness with the application of a previously described regularization technique.

Proposal of Evolutionary Simplex Method for Global Optimization Problem

NASA Astrophysics Data System (ADS)

Shimizu, Yoshiaki

To make an agile decision in a rational manner, role of optimization engineering has been notified increasingly under diversified customer demand. With this point of view, in this paper, we have proposed a new evolutionary method serving as an optimization technique in the paradigm of optimization engineering. The developed method has prospects to solve globally various complicated problem appearing in real world applications. It is evolved from the conventional method known as Nelder and Mead’s Simplex method by virtue of idea borrowed from recent meta-heuristic method such as PSO. Mentioning an algorithm to handle linear inequality constraints effectively, we have validated effectiveness of the proposed method through comparison with other methods using several benchmark problems.

Context Dependent Spectral Unmixing

DTIC Science & Technology

2014-08-01

the tar- get sizes). The targets were made of 100% cotton fabric and were emplaced so that there would be representatives of each color type completely...method for simplex-based endmember extraction algorithm,” IEEE Transactions on Geoscience and Re- mote Sensing, vol. 44, no. 10, pp. 2804–2819, 2006. [68

The CORSAIR Turbomachinery Code: Status and Plans

NASA Technical Reports Server (NTRS)

Dorney, Daniel J.; Sondak, Douglas L.; Turner, James (Technical Monitor)

2002-01-01

This viewgraph presentation gives an overview of the CORSAIR turbomachinery code's status and plans. Details are provided on the CORSAIR algorithms, full- and partial-admission turbine simulations, the Simplex turbine, instantaneous Mach number, unsteady pressure admission graphs, variable fluid property RLV-133 simulations, instantaneous entropy function, pumps and inducers, and future plans.

Evaporation from Lake Mead, Arizona and Nevada, 1997-99

USGS Publications Warehouse

Westenburg, Craig L.; DeMeo, Guy A.; Tanko, Daron J.

2006-01-01

Lake Mead is one of a series of large Colorado River reservoirs operated and maintained by the Bureau of Reclamation. The Colorado River system of reservoirs and diversions is an important source of water for millions of people in seven Western States and Mexico. The U.S. Geological Survey, in cooperation with the Bureau of Reclamation, conducted a study from 1997 to 1999 to estimate evaporation from Lake Mead. For this study, micrometeorological and hydrologic data were collected continually from instrumented platforms deployed at four locations on the lake, open-water areas of Boulder Basin, Virgin Basin, and Overton Arm and a protected cove in Boulder Basin. Data collected at the platforms were used to estimate Lake Mead evaporation by solving an energy-budget equation. The average annual evaporation rate at open-water stations from January 1998 to December 1999 was 7.5 feet. Because the spatial variation of monthly and annual evaporation rates was minimal for the open-water stations, a single open-water station in Boulder Basin would provide data that are adequate to estimate evaporation from Lake Mead.

3D Radiative Transfer in Eta Carinae: Application of the SimpleX Algorithm to 3D SPH Simulations of Binary Colliding Winds

NASA Technical Reports Server (NTRS)

Clementel, N.; Madura, T. I.; Kruip, C. J. H.; Icke, V.; Gull, T. R.

2014-01-01

Eta Carinae is an ideal astrophysical laboratory for studying massive binary interactions and evolution, and stellar wind-wind collisions. Recent three-dimensional (3D) simulations set the stage for understanding the highly complex 3D flows in Eta Car. Observations of different broad high- and low-ionization forbidden emission lines provide an excellent tool to constrain the orientation of the system, the primary's mass-loss rate, and the ionizing flux of the hot secondary. In this work we present the first steps towards generating synthetic observations to compare with available and future HST/STIS data. We present initial results from full 3D radiative transfer simulations of the interacting winds in Eta Car. We use the SimpleX algorithm to post-process the output from 3D SPH simulations and obtain the ionization fractions of hydrogen and helium assuming three different mass-loss rates for the primary star. The resultant ionization maps of both species constrain the regions where the observed forbidden emission lines can form. Including collisional ionization is necessary to achieve a better description of the ionization states, especially in the areas shielded from the secondary's radiation. We find that reducing the primary's mass-loss rate increases the volume of ionized gas, creating larger areas where the forbidden emission lines can form. We conclude that post processing 3D SPH data with SimpleX is a viable tool to create ionization maps for Eta Car.

3D Radiative Transfer in Eta Carinae: Application of the SimpleX Algorithm to 3D SPH Simulations of Binary Colliding Winds

NASA Technical Reports Server (NTRS)

Clementel, N.; Madura, T. I.; Kruip, C.J.H.; Icke, V.; Gull, T. R.

2014-01-01

Eta Carinae is an ideal astrophysical laboratory for studying massive binary interactions and evolution, and stellar wind-wind collisions. Recent three-dimensional (3D) simulations set the stage for understanding the highly complex 3D flows in eta Car. Observations of different broad high- and low-ionization forbidden emission lines provide an excellent tool to constrain the orientation of the system, the primary's mass-loss rate, and the ionizing flux of the hot secondary. In this work we present the first steps towards generating synthetic observations to compare with available and future HST/STIS data. We present initial results from full 3D radiative transfer simulations of the interacting winds in eta Car.We use the SimpleX algorithm to post-process the output from 3D SPH simulations and obtain the ionization fractions of hydrogen and helium assuming three different mass-loss rates for the primary star. The resultant ionization maps of both species constrain the regions where the observed forbidden emission lines can form. Including collisional ionization is necessary to achieve a better description of the ionization states, especially in the areas shielded from the secondary's radiation. We find that reducing the primary's mass-loss rate increases the volume of ionized gas, creating larger areas where the forbidden emission lines can form.We conclude that post processing 3D SPH data with SimpleX is a viable tool to create ionization maps for eta Car.

Optimization of cutting parameters for machining time in turning process

NASA Astrophysics Data System (ADS)

Mavliutov, A. R.; Zlotnikov, E. G.

2018-03-01

This paper describes the most effective methods for nonlinear constraint optimization of cutting parameters in the turning process. Among them are Linearization Programming Method with Dual-Simplex algorithm, Interior Point method, and Augmented Lagrangian Genetic Algorithm (ALGA). Every each of them is tested on an actual example – the minimization of production rate in turning process. The computation was conducted in the MATLAB environment. The comparative results obtained from the application of these methods show: The optimal value of the linearized objective and the original function are the same. ALGA gives sufficiently accurate values, however, when the algorithm uses the Hybrid function with Interior Point algorithm, the resulted values have the maximal accuracy.

The Effect of the Nunn-McCurdy Amendment on Unit-Cost-Growth of Defense Acquisition Projects

DTIC Science & Technology

2010-07-01

Congressional testimony: “I consider Virginia Class cost-reduction efforts a model for all our ships, submarines, and aircraft” (Roughhead, 2009...PATRIOT/MEADS CAP- MISSLE 2004 DE STRYKER 2004 PdE WIN-T INCREMENT 1 2007 PdE WIN-T INCREMENT 2 2007 DE Subtot~l Navy: ADS (ANJWOR-3) 2005 DE AGM...JAVELIN JLENS LONGBOW APACHE LUH PATRIOT PAC-3 PATRIOT/MEADS CAP - FIRE UNIT PATRIOT/MEADS CAP - MISSLE STRYKER WIN-T INCREMENT 1 WIN-T

Preliminary Geologic Map of the Lake Mead 30' X 60' Quadrangle, Clark County, Nevada, and Mohave County, Arizona

USGS Publications Warehouse

Beard, L.S.; Anderson, R.E.; Block, D.L.; Bohannon, R.G.; Brady, R.J.; Castor, S.B.; Duebendorfer, E.M.; Faulds, J.E.; Felger, T.J.; Howard, K.A.; Kuntz, M.A.; Williams, V.S.

2007-01-01

Introduction The geologic map of the Lake Mead 30' x 60' quadrangle was completed for the U.S. Geological Survey's Las Vegas Urban Corridor Project and the National Parks Project, National Cooperative Geologic Mapping Program. Lake Mead, which occupies the northern part of the Lake Mead National Recreation Area (LAME), mostly lies within the Lake Mead quadrangle and provides recreation for about nine million visitors annually. The lake was formed by damming of the Colorado River by Hoover Dam in 1939. The recreation area and surrounding Bureau of Land Management lands face increasing public pressure from rapid urban growth in the Las Vegas area to the west. This report provides baseline earth science information that can be used in future studies of hazards, groundwater resources, mineral and aggregate resources, and of soils and vegetation distribution. The preliminary report presents a geologic map and GIS database of the Lake Mead quadrangle and a description and correlation of map units. The final report will include cross-sections and interpretive text. The geology was compiled from many sources, both published and unpublished, including significant new mapping that was conducted specifically for this compilation. Geochronologic data from published sources, as well as preliminary unpublished 40Ar/39Ar ages that were obtained for this report, have been used to refine the ages of formal Tertiary stratigraphic units and define new informal Tertiary sedimentary and volcanic units.

Design Optimization of Space Launch Vehicles Using a Genetic Algorithm

DTIC Science & Technology

2007-06-01

function until no improvement in the objective function could be made. The search space is modeled in a geometric form such as a polyhedron . The simplex... database . AeroDesign assumes that there are no boundary layers and that no separation occurs. AeroDesign can analyze either a cone or ogive shape

The Shortlist Method for fast computation of the Earth Mover's Distance and finding optimal solutions to transportation problems.

PubMed

Gottschlich, Carsten; Schuhmacher, Dominic

2014-01-01

Finding solutions to the classical transportation problem is of great importance, since this optimization problem arises in many engineering and computer science applications. Especially the Earth Mover's Distance is used in a plethora of applications ranging from content-based image retrieval, shape matching, fingerprint recognition, object tracking and phishing web page detection to computing color differences in linguistics and biology. Our starting point is the well-known revised simplex algorithm, which iteratively improves a feasible solution to optimality. The Shortlist Method that we propose substantially reduces the number of candidates inspected for improving the solution, while at the same time balancing the number of pivots required. Tests on simulated benchmarks demonstrate a considerable reduction in computation time for the new method as compared to the usual revised simplex algorithm implemented with state-of-the-art initialization and pivot strategies. As a consequence, the Shortlist Method facilitates the computation of large scale transportation problems in viable time. In addition we describe a novel method for finding an initial feasible solution which we coin Modified Russell's Method.

The Shortlist Method for Fast Computation of the Earth Mover's Distance and Finding Optimal Solutions to Transportation Problems

PubMed Central

Gottschlich, Carsten; Schuhmacher, Dominic

2014-01-01

Finding solutions to the classical transportation problem is of great importance, since this optimization problem arises in many engineering and computer science applications. Especially the Earth Mover's Distance is used in a plethora of applications ranging from content-based image retrieval, shape matching, fingerprint recognition, object tracking and phishing web page detection to computing color differences in linguistics and biology. Our starting point is the well-known revised simplex algorithm, which iteratively improves a feasible solution to optimality. The Shortlist Method that we propose substantially reduces the number of candidates inspected for improving the solution, while at the same time balancing the number of pivots required. Tests on simulated benchmarks demonstrate a considerable reduction in computation time for the new method as compared to the usual revised simplex algorithm implemented with state-of-the-art initialization and pivot strategies. As a consequence, the Shortlist Method facilitates the computation of large scale transportation problems in viable time. In addition we describe a novel method for finding an initial feasible solution which we coin Modified Russell's Method. PMID:25310106

32 CFR Appendix B to Part 518 - Addressing FOIA Requests

Code of Federal Regulations, 2011 CFR

2011-07-01

... Avenue, Fort George G. Meade, MD 20755-5360. (6) Records involving debarred or suspended contractors..., ATTN: IAMG-CIC-FOI/PO, 4552 Pike Road, Fort George G. Meade, MD 20755-5995. (k) Inspector General...

32 CFR Appendix B to Part 518 - Addressing FOIA Requests

Code of Federal Regulations, 2014 CFR

2014-07-01

... Avenue, Fort George G. Meade, MD 20755-5360. (6) Records involving debarred or suspended contractors..., ATTN: IAMG-CIC-FOI/PO, 4552 Pike Road, Fort George G. Meade, MD 20755-5995. (k) Inspector General...

32 CFR Appendix B to Part 518 - Addressing FOIA Requests

Code of Federal Regulations, 2012 CFR

2012-07-01

... Avenue, Fort George G. Meade, MD 20755-5360. (6) Records involving debarred or suspended contractors..., ATTN: IAMG-CIC-FOI/PO, 4552 Pike Road, Fort George G. Meade, MD 20755-5995. (k) Inspector General...

32 CFR Appendix B to Part 518 - Addressing FOIA Requests

Code of Federal Regulations, 2013 CFR

2013-07-01

... Avenue, Fort George G. Meade, MD 20755-5360. (6) Records involving debarred or suspended contractors..., ATTN: IAMG-CIC-FOI/PO, 4552 Pike Road, Fort George G. Meade, MD 20755-5995. (k) Inspector General...

Improvements to Air Force Strategic Basing Decisions

DTIC Science & Technology

2016-01-01

Fort Lee, VA 10,200 4,600 14,800 138,000 Fort Lewis, WA 13,500 17,400 30,900 3,422,000 Fort Meade , MD 7,000 4,200 11,200 2,512,000 Fort Sam...Aberdeen Proving Grounds, Fort Meade , and the Bethesda National Naval Medical Center were scheduled to add over 12,000 personnel in total. The state of...Influences on Air Force Basing Decisions According to Edward Mead Earle, “Strategy is the art of controlling and utilizing the resources of a nation—or a

A Comparison of the Operational Art of George Gordon Meade and Robert Edward Lee during the Period June 1863, to March 1864.

DTIC Science & Technology

1988-03-29

PERIOD COVERED A Comparison of the Operational Art of George G. Meade and Robert E. Lee During the Period Jun 1 8 6 3 Indiv study project to March...publication until it has been cleared by the appropriate military Service er gover"uent aency. A Comparison Of The Operational Art Of George Gordon...and/or Dis Speclal;! Sp ABSTRACT AUTHOR: THOMAS A. GREEN, LTC, AV. TITLE: A Comparison of the Operational Art of George Gordon Meade and Robert Edward

Infant formula companies battle for breast.

PubMed

1996-01-01

The infant formula manufacturer Mead Johnson has filed a lawsuit in Ontario courts against its competitor Ross Abbott for false advertising of its new Similac brand of infant formula. Mead Johnson contends that the Ross Abbott advertisement of Similac as providing benefits similar to mother's milk is false and misleading. Breast feeding specialists agree with Mead Johnson's claim. Yet, one year earlier, Mead Johnson claimed that its infant formula is modeled after mother's milk. The Infant Feeding Action Coalition (INFACT) Canada had complained to the Competition Bureau that called for Mead Johnson to cease its claim. Court documents reveal that both companies disregard the World Health Organization (WHO) International Code of Marketing of Breast Milk Substitutes. This code prohibits manufacturers from advertising directly to pregnant women and mothers. Two Ross Abbott spokespersons have different responses to their advertising practices: increasing emphasis on consumer promotion and support of the principle and objective of the WHO Code. Both companies have sought support of health professionals in Canada. In July 1996 Mead Johnson sent letters to about 7000 clinicians declaring "as someone who cares about infant health and nutrition as much as we do" and "...the most alarming concern is that, although there is no scientific basis for such claims, mothers believe them to be true." Ross Abbott responded to these letters by sending physicians letters declaring "Our business is built on trust, and we assure you that you may trust in Similac Advance and the benefits we have ascribed to it." The two companies will meet again in court on September 30, 1996.

Ten years of research on the MeadWestvaco Wildlife and Ecosystem Research Forest

Treesearch

P.D. Keyser; W.M. Ford; W.M. Ford

2005-01-01

Contains 90 citations and annotations of publications and final reports that describe research conducted on or in association with the MeadWestvaco Wildlife and Ecosystem Research Forest in West Virginia from 1994 through 2004.

77 FR 42713 - Notice of Intent to Grant an Exclusive License; PadJack, Inc.

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-20

... Security Agency Technology Transfer Program, 9800 Savage Road, Suite 6541, Fort George G. Meade, MD 20755... Savage Road, Suite 6541, Fort George G. Meade, MD 20755-6541, telephone (443) 479-9569. Dated: July 17...

Automatic Generation of Algorithms for the Statistical Analysis of Planetary Nebulae Images

NASA Technical Reports Server (NTRS)

Fischer, Bernd

2004-01-01

Analyzing data sets collected in experiments or by observations is a Core scientific activity. Typically, experimentd and observational data are &aught with uncertainty, and the analysis is based on a statistical model of the conjectured underlying processes, The large data volumes collected by modern instruments make computer support indispensible for this. Consequently, scientists spend significant amounts of their time with the development and refinement of the data analysis programs. AutoBayes [GF+02, FS03] is a fully automatic synthesis system for generating statistical data analysis programs. Externally, it looks like a compiler: it takes an abstract problem specification and translates it into executable code. Its input is a concise description of a data analysis problem in the form of a statistical model as shown in Figure 1; its output is optimized and fully documented C/C++ code which can be linked dynamically into the Matlab and Octave environments. Internally, however, it is quite different: AutoBayes derives a customized algorithm implementing the given model using a schema-based process, and then further refines and optimizes the algorithm into code. A schema is a parameterized code template with associated semantic constraints which define and restrict the template s applicability. The schema parameters are instantiated in a problem-specific way during synthesis as AutoBayes checks the constraints against the original model or, recursively, against emerging sub-problems. AutoBayes schema library contains problem decomposition operators (which are justified by theorems in a formal logic in the domain of Bayesian networks) as well as machine learning algorithms (e.g., EM, k-Means) and nu- meric optimization methods (e.g., Nelder-Mead simplex, conjugate gradient). AutoBayes augments this schema-based approach by symbolic computation to derive closed-form solutions whenever possible. This is a major advantage over other statistical data analysis systems which use numerical approximations even in cases where closed-form solutions exist. AutoBayes is implemented in Prolog and comprises approximately 75.000 lines of code. In this paper, we take one typical scientific data analysis problem-analyzing planetary nebulae images taken by the Hubble Space Telescope-and show how AutoBayes can be used to automate the implementation of the necessary anal- ysis programs. We initially follow the analysis described by Knuth and Hajian [KHO2] and use AutoBayes to derive code for the published models. We show the details of the code derivation process, including the symbolic computations and automatic integration of library procedures, and compare the results of the automatically generated and manually implemented code. We then go beyond the original analysis and use AutoBayes to derive code for a simple image segmentation procedure based on a mixture model which can be used to automate a manual preproceesing step. Finally, we combine the original approach with the simple segmentation which yields a more detailed analysis. This also demonstrates that AutoBayes makes it easy to combine different aspects of data analysis.

An Improved Strong Tracking Cubature Kalman Filter for GPS/INS Integrated Navigation Systems.

PubMed

Feng, Kaiqiang; Li, Jie; Zhang, Xi; Zhang, Xiaoming; Shen, Chong; Cao, Huiliang; Yang, Yanyu; Liu, Jun

2018-06-12

The cubature Kalman filter (CKF) is widely used in the application of GPS/INS integrated navigation systems. However, its performance may decline in accuracy and even diverge in the presence of process uncertainties. To solve the problem, a new algorithm named improved strong tracking seventh-degree spherical simplex-radial cubature Kalman filter (IST-7thSSRCKF) is proposed in this paper. In the proposed algorithm, the effect of process uncertainty is mitigated by using the improved strong tracking Kalman filter technique, in which the hypothesis testing method is adopted to identify the process uncertainty and the prior state estimate covariance in the CKF is further modified online according to the change in vehicle dynamics. In addition, a new seventh-degree spherical simplex-radial rule is employed to further improve the estimation accuracy of the strong tracking cubature Kalman filter. In this way, the proposed comprehensive algorithm integrates the advantage of 7thSSRCKF’s high accuracy and strong tracking filter’s strong robustness against process uncertainties. The GPS/INS integrated navigation problem with significant dynamic model errors is utilized to validate the performance of proposed IST-7thSSRCKF. Results demonstrate that the improved strong tracking cubature Kalman filter can achieve higher accuracy than the existing CKF and ST-CKF, and is more robust for the GPS/INS integrated navigation system.

An Approach to Unbiased Subsample Interpolation for Motion Tracking

PubMed Central

McCormick, Matthew M.; Varghese, Tomy

2013-01-01

Accurate subsample displacement estimation is necessary for ultrasound elastography because of the small deformations that occur and the subsequent application of a derivative operation on local displacements. Many of the commonly used subsample estimation techniques introduce significant bias errors. This article addresses a reduced bias approach to subsample displacement estimations that consists of a two-dimensional windowed-sinc interpolation with numerical optimization. It is shown that a Welch or Lanczos window with a Nelder–Mead simplex or regular-step gradient-descent optimization is well suited for this purpose. Little improvement results from a sinc window radius greater than four data samples. The strain signal-to-noise ratio (SNR) obtained in a uniformly elastic phantom is compared with other parabolic and cosine interpolation methods; it is found that the strain SNR ratio is improved over parabolic interpolation from 11.0 to 13.6 in the axial direction and 0.7 to 1.1 in the lateral direction for an applied 1% axial deformation. The improvement was most significant for small strains and displacement tracking in the lateral direction. This approach does not rely on special properties of the image or similarity function, which is demonstrated by its effectiveness with the application of a previously described regularization technique. PMID:23493609

Long-period gratings in photonic crystal fibers operating near the phase-matching turning point for evanescent chemical and biochemical sensing

NASA Astrophysics Data System (ADS)

Kanka, Jiri

2012-06-01

Fiber-optic long-period grating (LPG) operating near the dispersion turning point in its phase matching curve (PMC), referred to as a Turn Around Point (TAP) LPG, is known to be extremely sensitive to external parameters. Moreover, in a TAP LPG the phase matching condition can be almost satisfied over large spectral range, yielding a broadband LPG operation. TAP LPGs have been investigated, namely for use as broadband mode convertors and biosensors. So far TAP LPGs have been realized in specially designed or post-processed conventional fibers, not yet in PCFs, which allow a great degree of freedom in engineering the fiber's dispersion properties through the control of the PCF structural parameters. We have developed the design optimization technique for TAP PCF LPGs employing the finite element method for PCF modal analysis in a combination with the Nelder-Mead simplex method for minimizing the objective function based on target-specific PCF properties. Using this tool we have designed TAP PCF LPGs for specified wavelength ranges and refractive indices of medium in the air holes. Possible TAP PCF-LPG operational regimes - dual-resonance, broadband mode conversion and transmitted intensity-based operation - will be demonstrated numerically. Potential and limitations of TAP PCF-LPGs for evanescent chemical and biochemical sensing will be assessed.

Determination of phenolic compounds and hydroxymethylfurfural in meads using high performance liquid chromatography with coulometric-array and UV detection.

PubMed

Kahoun, David; Rezková, Sona; Veskrnová, Katerina; Královský, Josef; Holcapek, Michal

2008-08-15

The objective of this study was the determination of 25 phenolic compounds in different mead samples (honeywines) using high performance liquid chromatography (HPLC) with coulometric-array detection and in case of hydroxymethylfurfural with UV detection. Our method was optimized in respect to both the separation selectivity of individual phenolic compounds and the maximum sensitivity with the electrochemical detection. The method development included the optimization of mobile phase composition, the pH value, conditions of the gradient elution and the flow rate using a window-diagram approach. The developed method was used for the determination of limits of detection and limits of quantitation for individual compounds. The linearity of calibration curves, accuracy and precision (intra- and inter-day) at three concentration levels (low, middle and high concentration range) were verified. Mead samples were diluted with the mobile phase at 1:1 to 1:50 ratio depending on the concentration and filtered through a PTFE filter without any other sample pre-treatment. Phenolic compounds concentration was determined in 50 real samples of meads and correlated with meads composition and hydroxymethylfurfural concentration. The most frequently occurred compounds were protocatechuic acid and vanillic acid (both of them were present in 98% samples), the least occurred compounds were (+)-catechin (10% samples) and sinapic acid (12% samples). Vanillin and ethylvanillin, which are used as artificial additives for the taste improvement, were found in 60% and 42% samples, respectively. Hydroxymethylfurfural concentration, as an indicator of honey quality, was in the range from 2.47 to 158 mg/L. Our method is applicable for the determination of 25 phenolic compounds in mead, honey and related natural samples.

Satellite Observations of Drought and Falling Water Storage in the Colorado River Basin and Lake Mead

NASA Astrophysics Data System (ADS)

Castle, S.; Famiglietti, J. S.; Reager, J. T.; Thomas, B.

2012-12-01

Over the past decade the Western US has experienced extreme drought conditions, which have affected both agricultural and urban areas. An example of water infrastructure being impacted by these droughts is Lake Mead, the largest reservoir in the United States at its full capacity that provides water and energy for several states in the Western US. Once Lake Mead falls below the critical elevation of 1050 feet above sea level, the Hoover Dam, the structure that created Lake Mead by damming flow within the Colorado River, will stop producing energy for Las Vegas. The Gravity Recovery and Climate Experiment (GRACE) satellites, launched in 2002, have proven successful for monitoring changes in water storage over large areas, and give hydrologists a first-ever picture of how total water storage is changing spatially and temporally within large regions. Given the importance of the Colorado River to meet water demands to several neighboring regions, including Southern California, it is vital to understand how water is transported and managed throughout the basin. In this research, we use hydrologic remote sensing to characterize the human and natural water balance of the Colorado River basin and Lake Mead. The research will include quantifying the amount of Colorado River water delivered to Southern California, coupling the GRACE Total Water Storage signal of the Upper and Lower Colorado River with Landsat-TM satellite imagery and areal extent of Lake Mead water storage, and combining these data together to determine the current status of water availability in the Western US. We consider water management and policy changes necessary for sustainable water practices including human water use, hydropower, and ecosystem services in arid regions throughout the Western US.

An exact algorithm for optimal MAE stack filter design.

PubMed

Dellamonica, Domingos; Silva, Paulo J S; Humes, Carlos; Hirata, Nina S T; Barrera, Junior

2007-02-01

We propose a new algorithm for optimal MAE stack filter design. It is based on three main ingredients. First, we show that the dual of the integer programming formulation of the filter design problem is a minimum cost network flow problem. Next, we present a decomposition principle that can be used to break this dual problem into smaller subproblems. Finally, we propose a specialization of the network Simplex algorithm based on column generation to solve these smaller subproblems. Using our method, we were able to efficiently solve instances of the filter problem with window size up to 25 pixels. To the best of our knowledge, this is the largest dimension for which this problem was ever solved exactly.

Kinetic and dynamic Delaunay tetrahedralizations in three dimensions

NASA Astrophysics Data System (ADS)

Schaller, Gernot; Meyer-Hermann, Michael

2004-09-01

We describe algorithms to implement fully dynamic and kinetic three-dimensional unconstrained Delaunay triangulations, where the time evolution of the triangulation is not only governed by moving vertices but also by a changing number of vertices. We use three-dimensional simplex flip algorithms, a stochastic visibility walk algorithm for point location and in addition, we propose a new simple method of deleting vertices from an existing three-dimensional Delaunay triangulation while maintaining the Delaunay property. As an example, we analyse the performance in various cases of practical relevance. The dual Dirichlet tessellation can be used to solve differential equations on an irregular grid, to define partitions in cell tissue simulations, for collision detection etc.

A technical report on structural evaluation of the Meade County reinforced concrete bridge.

DOT National Transportation Integrated Search

2009-01-01

This is a technical report on the first phase of the evaluation of the Meade County reinforced concrete bridge. : The first three chapters introduce the main problem and provide a general review of the existing evaluation : methods and the procedures...

Chaos synchronization and Nelder-Mead search for parameter estimation in nonlinear pharmacological systems: Estimating tumor antigenicity in a model of immunotherapy.

PubMed

Pillai, Nikhil; Craig, Morgan; Dokoumetzidis, Aristeidis; Schwartz, Sorell L; Bies, Robert; Freedman, Immanuel

2018-06-19

In mathematical pharmacology, models are constructed to confer a robust method for optimizing treatment. The predictive capability of pharmacological models depends heavily on the ability to track the system and to accurately determine parameters with reference to the sensitivity in projected outcomes. To closely track chaotic systems, one may choose to apply chaos synchronization. An advantageous byproduct of this methodology is the ability to quantify model parameters. In this paper, we illustrate the use of chaos synchronization combined with Nelder-Mead search to estimate parameters of the well-known Kirschner-Panetta model of IL-2 immunotherapy from noisy data. Chaos synchronization with Nelder-Mead search is shown to provide more accurate and reliable estimates than Nelder-Mead search based on an extended least squares (ELS) objective function. Our results underline the strength of this approach to parameter estimation and provide a broader framework of parameter identification for nonlinear models in pharmacology. Copyright © 2018 Elsevier Ltd. All rights reserved.

Plague and contagionism in eighteenth-century England: the role of Richard Mead.

PubMed

Zuckerman, Arnold

2004-01-01

An epidemic of plague in Marseilles in 1720 and the fear that it would spread to England led to the passing of a new quarantine act. First, however, the government sought medical advice from Dr. Richard Mead (1673-1754), which took the form of A Short Discourse Concerning Pestilential Contagion, and the Methods to Be Used to Prevent It. This tract was a contribution to the contagion concept of disease at a time when it had not yet become part of the medical mainstream as an explanation for certain epidemic diseases. Critical works appeared almost immediately attacking Mead's ideas. The Short Discourse went through nine editions, the last in 1744. In the last two editions there are further elaborations of his earlier views and references to Newton's Optics and the ether theory. Some of Mead's practical recommendations for dealing with the plague, should it enter the country, were relatively new. References to his plague tract appeared in a number of medical and nonmedical works well beyond his lifetime.

Bottom Sediment as a Source of Organic Contaminants in Lake Mead, Nevada, USA

EPA Science Inventory

Treated wastewater effluent from Las Vegas, Nevada and surrounding communities’ flow through Las Vegas Wash (LVW) into the Lake Mead National Recreational Area at Las Vegas Bay (LVB). Lake sediment is a likely sink for many hydrophobic synthetic organic compounds (SOCs); however,...

Sources and distribution of organic compounds using passive samplers in Lake Mead National Recreation Area, Nevada and Arizona, and their implications for potential effects on aquatic biota.

USGS Publications Warehouse

Rosen, Michael R.; Alvarez, David A.; Goodbred, Steven L.; Leiker, Thomas J.; Patino, Reynaldo

2009-01-01

compounds (SOCs) at pg L-1 concentrations. Semi-permeable membrane devices and POCIS were deployed in Lake Mead, at two sites in Las Vegas Wash, at four sites across Lake Mead, and in the Colorado River downstream from Hoover Dam. Concentrations of hydrophobic SOCs were highest in Las Vegas Wash downstream from waste water and urban inputs and at 8 m depth in Las Vegas Bay (LVB) where Las Vegas Wash enters Lake Mead. Th e distribution of hydrophobic SOCs showed a lateral distribution across 10 km of Lake Mead from LVB to Boulder Basin. To assess possible vertical gradients of SOCs, SPMDs were deployed at 4-m intervals in 18 m of water in LVB. Fragrances and legacy SOCs were found at the greatest concentrations at the deepest depth. Th e vertical gradient of SOCs indicated that contaminants were generally confi ned to within 6 m of the lake bottom during the deployment interval. The high SOC concentrations, warmer water temperatures, and higher total dissolved solids concentrations at depth are indicative of a plume of Las Vegas Wash water moving along the lake bottom. Th e lateral and vertical distribution of SOCs is discussed in the context of other studies that have shown impaired health of fi sh exposed to SOCs.

An evolutionary firefly algorithm for the estimation of nonlinear biological model parameters.

PubMed

Abdullah, Afnizanfaizal; Deris, Safaai; Anwar, Sohail; Arjunan, Satya N V

2013-01-01

The development of accurate computational models of biological processes is fundamental to computational systems biology. These models are usually represented by mathematical expressions that rely heavily on the system parameters. The measurement of these parameters is often difficult. Therefore, they are commonly estimated by fitting the predicted model to the experimental data using optimization methods. The complexity and nonlinearity of the biological processes pose a significant challenge, however, to the development of accurate and fast optimization methods. We introduce a new hybrid optimization method incorporating the Firefly Algorithm and the evolutionary operation of the Differential Evolution method. The proposed method improves solutions by neighbourhood search using evolutionary procedures. Testing our method on models for the arginine catabolism and the negative feedback loop of the p53 signalling pathway, we found that it estimated the parameters with high accuracy and within a reasonable computation time compared to well-known approaches, including Particle Swarm Optimization, Nelder-Mead, and Firefly Algorithm. We have also verified the reliability of the parameters estimated by the method using an a posteriori practical identifiability test.

An Evolutionary Firefly Algorithm for the Estimation of Nonlinear Biological Model Parameters

PubMed Central

Abdullah, Afnizanfaizal; Deris, Safaai; Anwar, Sohail; Arjunan, Satya N. V.

2013-01-01

The development of accurate computational models of biological processes is fundamental to computational systems biology. These models are usually represented by mathematical expressions that rely heavily on the system parameters. The measurement of these parameters is often difficult. Therefore, they are commonly estimated by fitting the predicted model to the experimental data using optimization methods. The complexity and nonlinearity of the biological processes pose a significant challenge, however, to the development of accurate and fast optimization methods. We introduce a new hybrid optimization method incorporating the Firefly Algorithm and the evolutionary operation of the Differential Evolution method. The proposed method improves solutions by neighbourhood search using evolutionary procedures. Testing our method on models for the arginine catabolism and the negative feedback loop of the p53 signalling pathway, we found that it estimated the parameters with high accuracy and within a reasonable computation time compared to well-known approaches, including Particle Swarm Optimization, Nelder-Mead, and Firefly Algorithm. We have also verified the reliability of the parameters estimated by the method using an a posteriori practical identifiability test. PMID:23469172

A fast rigid-registration method of inferior limb X-ray image and 3D CT images for TKA surgery

NASA Astrophysics Data System (ADS)

Ito, Fumihito; O. D. A, Prima; Uwano, Ikuko; Ito, Kenzo

2010-03-01

In this paper, we propose a fast rigid-registration method of inferior limb X-ray films (two-dimensional Computed Radiography (CR) images) and three-dimensional Computed Tomography (CT) images for Total Knee Arthroplasty (TKA) surgery planning. The position of the each bone, such as femur and tibia (shin bone), in X-ray film and 3D CT images is slightly different, and we must pay attention how to use the two different images, since X-ray film image is captured in the standing position, and 3D CT is captured in decubitus (face up) position, respectively. Though the conventional registration mainly uses cross-correlation function between two images,and utilizes optimization techniques, it takes enormous calculation time and it is difficult to use it in interactive operations. In order to solve these problems, we calculate the center line (bone axis) of femur and tibia (shin bone) automatically, and we use them as initial positions for the registration. We evaluate our registration method by using three patient's image data, and we compare our proposed method and a conventional registration, which uses down-hill simplex algorithm. The down-hill simplex method is an optimization algorithm that requires only function evaluations, and doesn't need the calculation of derivatives. Our registration method is more effective than the downhill simplex method in computational time and the stable convergence. We have developed the implant simulation system on a personal computer, in order to support the surgeon in a preoperative planning of TKA. Our registration method is implemented in the simulation system, and user can manipulate 2D/3D translucent templates of implant components on X-ray film and 3D CT images.

Automated real-time search and analysis algorithms for a non-contact 3D profiling system

NASA Astrophysics Data System (ADS)

Haynes, Mark; Wu, Chih-Hang John; Beck, B. Terry; Peterman, Robert J.

2013-04-01

The purpose of this research is to develop a new means of identifying and extracting geometrical feature statistics from a non-contact precision-measurement 3D profilometer. Autonomous algorithms have been developed to search through large-scale Cartesian point clouds to identify and extract geometrical features. These algorithms are developed with the intent of providing real-time production quality control of cold-rolled steel wires. The steel wires in question are prestressing steel reinforcement wires for concrete members. The geometry of the wire is critical in the performance of the overall concrete structure. For this research a custom 3D non-contact profilometry system has been developed that utilizes laser displacement sensors for submicron resolution surface profiling. Optimizations in the control and sensory system allow for data points to be collected at up to an approximate 400,000 points per second. In order to achieve geometrical feature extraction and tolerancing with this large volume of data, the algorithms employed are optimized for parsing large data quantities. The methods used provide a unique means of maintaining high resolution data of the surface profiles while keeping algorithm running times within practical bounds for industrial application. By a combination of regional sampling, iterative search, spatial filtering, frequency filtering, spatial clustering, and template matching a robust feature identification method has been developed. These algorithms provide an autonomous means of verifying tolerances in geometrical features. The key method of identifying the features is through a combination of downhill simplex and geometrical feature templates. By performing downhill simplex through several procedural programming layers of different search and filtering techniques, very specific geometrical features can be identified within the point cloud and analyzed for proper tolerancing. Being able to perform this quality control in real time provides significant opportunities in cost savings in both equipment protection and waste minimization.

A Constructive Task in Religious Education: Making Christian Selves.

ERIC Educational Resources Information Center

Anderson, E. Byron

1998-01-01

Discusses the self as socially constructed by comparing George Herbert Mead and Robert Kegan and then addresses the construction of the religious self by focusing on Mead, Kegan, and George Lindbeck. Considers the "theonomous self" (identity related to God). Concludes by discussing ecclesial practices that correspond to the theonomous…

Mead and Dewey: Thematic Connections on Educational Topics.

ERIC Educational Resources Information Center

Dennis, Lawrence J.; Stickel, George W.

1981-01-01

Common themes emerge from the writings of John Dewey and George Herbert Mead on four educational topics discussed here: (1) play; (2) science teaching; (3) history teaching; and (4) industrial education. Both men deplored the fragmentation of education and believed moral insight could be furthered through social understanding, science, and…

A technical report on structural evaluation of the Meade County reinforced concrete bridge : research [summary].

DOT National Transportation Integrated Search

2009-01-01

Meade County Bridge is a two-lane highway reinforced concrete bridge with two girders each with 20 continuous spans. The bridge was built in 1965. It has been reported that in early years of the bridge service period, a considerable amount of cracks ...

Self-consolidating concrete repairs on Interstate 25 bridge abutments north of Mead.

DOT National Transportation Integrated Search

2013-07-01

In August of 2011 CDOT performed maintenance on Interstate 25 bridges D-17-DA and DB on I-25 north of Mead, CO. : The maintenance was performed using self-consolidating concrete (SCC), and the methods were based on a study performed : by the Colorado...

Margaret Mead's Early Fieldwork: Methods and Implications for Education.

ERIC Educational Resources Information Center

Kincheloe, Teresa Scott

1980-01-01

Reviews the early career of Margaret Mead (1928-1942) and study methods she used in Samoa, New Guinea, and Bali. Particular attention is paid to her examinations of sex roles and her own experiences as a female scientist. (Part of a theme issue on anthropological methods in educational research.) (SJL)

Lake Mead National Recreational Area air tour management plan and planning and National Environmental Policy Act scoping document

DOT National Transportation Integrated Search

2004-04-19

The Federal Aviation Administration (FAA), in cooperation with the National Park Service (NPS), has initiated the development of an Air Tour Management Plan (ATMP) for Lake Mead National Recreation Area (LAME) pursuant to the National Parks Air Tour ...

Persistence of echimidine, a hepatotoxic pyrrolizidine alkaloid, from honey into mead

USDA-ARS?s Scientific Manuscript database

Honey produced by bees foraging on Echium plantagineum is known to contain dehydropyrrolizidine alkaloids characteristic of the plant. Following a prolific growth of E. plantagineum in the wake of Australian bushfires, two samples of mead, a fermented drink made from honey, and the honey used to pre...

Using the Gilbert-Johnson-Keerthi Algorithm for Collision Detection in System Effectiveness Modeling

DTIC Science & Technology

2015-09-01

product is vector whose i-th component is defined as (A×B)i = εi jkA jBk, (2) 2 where εi jk is the Levi - Civita symbol whose value is 1 if i jk is an...of GJK 9 3.1.1 Overview of GJK 9 3.1.2 Two Examples of GJK Operating 9 3.1.3 Termination Conditions 11 3.1.4 GJK Algorithm 13 3.2 Simplex Processing...band will snap around the outermost points, forming the convex hull. ...........5 Fig. 3 Two example triangles and their Minkowski Difference

Advanced control concepts. [for shuttle ascent vehicles

NASA Technical Reports Server (NTRS)

Sharp, J. B.; Coppey, J. M.

1973-01-01

The problems of excess control devices and insufficient trim control capability on shuttle ascent vehicles were investigated. The trim problem is solved at all time points of interest using Lagrangian multipliers and a Simplex based iterative algorithm developed as a result of the study. This algorithm has the capability to solve any bounded linear problem with physically realizable constraints, and to minimize any piecewise differentiable cost function. Both solution methods also automatically distribute the command torques to the control devices. It is shown that trim requirements are unrealizable if only the orbiter engines and the aerodynamic surfaces are used.

Lake Mead and Drought

NASA Image and Video Library

2015-07-20

Lake Mead supplies water for Arizona, California, Mexico, and other western states. On June 23, the water level fell to 1075 feet, a record low. In 2000, for comparison, the water level was at 1214 feet. A 15-year drought and increased demands for water are to blame for the critical status of the water supply. The difference in 15 years is seen in this pair of images of the western part of Lake Mead, acquired June 21, 2000 by Landsat 7, and June 21, 2015 by ASTER. The images cover an area of 22.5 x 28.5 km, and are located at 36.1 degrees north, 114.7 degrees west. http://photojournal.jpl.nasa.gov/catalog/PIA19731

Fort Meade demonstration test LEDS in freezer rooms, fiber optics in display cases

DOE Office of Scientific and Technical Information (OSTI.GOV)

Parker, Steven; Parker, Graham B.

2008-10-25

Demonstration projects at Fort George G. Meade, MD, substituted LED lighting for incandescent bulbs in commisary wal-in freezers and fiber optic lighting in reach-in display cases. The goal was to reduce energy consumption and the results were positive. Journal article published in Public Works Digest

78 FR 25259 - Notice of Intent To Grant an Exclusive License; Integrata Security, LLC

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-30

..., 9800 Savage Road, Suite 6848, Fort George G. Meade, MD 20755-6848. FOR FURTHER INFORMATION CONTACT: Marian T. Roche, Director, Technology Transfer Program, 9800 Savage Road, Suite 6848, Fort George G. Meade, MD 20755-6848, telephone (443) 634-3514. Dated: April 24, 2013. Aaron Siegel, Alternate OSD...

Contorting Identities: Figuring Literacy and Identity in Adolescent Worlds

ERIC Educational Resources Information Center

Quinlan, A.; Curtin, A.

2017-01-01

This paper explores connections and disconnects between identity and literacy for a group of adolescents in a second level classroom setting. We build on Mead and Vygotsky's conceptualisations of identity formation as an intricate emergent happening constantly formed/reformed by people, in their interactions with others [Mead, G. H. 1999.…

Consuming Anomie: Children and Global Commercial Culture. Research Note

ERIC Educational Resources Information Center

Langer, Beryl

2005-01-01

This article locates George Herbert Meads account of self-formation in the context of global consumer capitalism, in which the "generalized other" is constructed as a desiring consumer. It argues for a sociology of consumer childhood that, via Mead, takes children's agency as a given and explores the implications of their interaction with the…

78 FR 26770 - MeadWestvaco Coated Board, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-08

... Coated Board, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of MeadWestvaco Coated Board, LLC's application for market-based rate authority, with an accompanying rate schedule...

75 FR 5115 - Temporary Concession Contract for Lake Mead National Recreation Area, AZ/NV

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-01

... National Recreation Area, AZ/NV AGENCY: National Park Service, Department of the Interior. ACTION: Notice of intention to award temporary concession contract for Lake Mead National Recreation Area. SUMMARY: Pursuant to 36 CFR 51.24, public notice is hereby given that the National Park Service intends to award a...

Mildly abnormal general movement quality in infants is associated with higher Mead acid and lower arachidonic acid and shows a U-shaped relation with the DHA/AA ratio.

PubMed

van Goor, S A; Schaafsma, A; Erwich, J J H M; Dijck-Brouwer, D A J; Muskiet, F A J

2010-01-01

We showed that docosahexaenoic acid (DHA) supplementation during pregnancy and lactation was associated with more mildly abnormal (MA) general movements (GMs) in the infants. Since this finding was unexpected and inter-individual DHA intakes are highly variable, we explored the relationship between GM quality and erythrocyte DHA, arachidonic acid (AA), DHA/AA and Mead acid in 57 infants of this trial. MA GMs were inversely related to AA, associated with Mead acid, and associated with DHA/AA in a U-shaped manner. These relationships may indicate dependence of newborn AA status on synthesis from linoleic acid. This becomes restricted during the intrauterine period by abundant de novo synthesis of oleic and Mead acids from glucose, consistent with reduced insulin sensitivity during the third trimester. The descending part of the U-shaped relation between MA GMs and DHA/AA probably indicates DHA shortage next to AA shortage. The ascending part may reflect a different developmental trajectory that is not necessarily unfavorable. Copyright 2009 Elsevier Ltd. All rights reserved.

Emplacement history of a thrust sheet based on analysis of pressure solution cleavage and deformed fossils

DOE Office of Scientific and Technical Information (OSTI.GOV)

Protzman, G.M.; Mitra, G.

The emplacement history of a thrust sheet is recorded by the strain accumulated in its hanging wall and footwall. Detailed studies of second order structures and analysis of strain due to pressure solution and plastic deformation allow the authors to determine the deformation history of the Meade thrust in the Idaho - Wyoming thrust belt. Emplacement of the Meade thrust was accompanied by the formation of a series of second order in echelon folds in the footwall. Temporal relations based on detailed structural studies show that these folds, which are confined to the Jurassic Twin Creek Formation, formed progressively inmore » front of the advancing Meade thrust and were successively truncated and overridden by footwall imbricates of the Meade thrust. The Twin Creek Formation in both the hanging wall and footwall of the Meade thrust is penetratively deformed, with a well developed pressure solution cleavage. In addition, plastic strain is recorded by deformed Pentacrinus within fossil hash layers in the Twin Creek. Much of this penetrative deformation took place early in the history of the thrust sheet as layer parallel shortening, and the cleavage and deformed fossils behaved passively during subsequent folding and faulting. The later stages of deformation may be sequentially removed through balancing techniques to track successive steps in the deformation. This strain history, which is typical of an internal thrust sheet, is partly controlled by the lithologies involved, timing between successive thrusts, and the amount of interaction between major faults.« less

On efficient randomized algorithms for finding the PageRank vector

NASA Astrophysics Data System (ADS)

Gasnikov, A. V.; Dmitriev, D. Yu.

2015-03-01

Two randomized methods are considered for finding the PageRank vector; in other words, the solution of the system p T = p T P with a stochastic n × n matrix P, where n ˜ 107-109, is sought (in the class of probability distributions) with accuracy ɛ: ɛ ≫ n -1. Thus, the possibility of brute-force multiplication of P by the column is ruled out in the case of dense objects. The first method is based on the idea of Markov chain Monte Carlo algorithms. This approach is efficient when the iterative process p {/t+1 T} = p {/t T} P quickly reaches a steady state. Additionally, it takes into account another specific feature of P, namely, the nonzero off-diagonal elements of P are equal in rows (this property is used to organize a random walk over the graph with the matrix P). Based on modern concentration-of-measure inequalities, new bounds for the running time of this method are presented that take into account the specific features of P. In the second method, the search for a ranking vector is reduced to finding the equilibrium in the antagonistic matrix game where S n (1) is a unit simplex in ℝ n and I is the identity matrix. The arising problem is solved by applying a slightly modified Grigoriadis-Khachiyan algorithm (1995). This technique, like the Nazin-Polyak method (2009), is a randomized version of Nemirovski's mirror descent method. The difference is that randomization in the Grigoriadis-Khachiyan algorithm is used when the gradient is projected onto the simplex rather than when the stochastic gradient is computed. For sparse matrices P, the method proposed yields noticeably better results.

Human-health pharmaceutical compounds in Lake Mead, Nevada and Arizona, and Las Vegas Wash, Nevada, October 2000-August 2001

USGS Publications Warehouse

Boyd, Robert A.; Furlong, Edward T.

2002-01-01

The U.S. Geological Survey and the National Park Service conducted a reconnaissance study to investigate the occurrence of selected human-health pharmaceutical compounds in water samples collected from Lake Mead on the Colorado River and Las Vegas Wash, a waterway used to transport treated wastewater from the Las Vegas metropolitan area to Lake Mead. Current research indicates many of these compounds can bioaccumulate and may adversely affect aquatic organisms by disrupting physiological processes, impairing reproductive functions, increasing cancer rates, contributing to the development of antibiotic-resistant strains of bacteria, and acting in undesirable ways when mixed with other substances. These compounds may be present in effluent because a high percentage of prescription and non-prescription drugs used for human-health purposes are excreted from the body as a mixture of parent compounds and degraded metabolite compounds; also, they can be released to the environment when unused products are discarded by way of toilets, sinks, and trash in landfills. Thirteen of 33 targeted compounds were detected in at least one water sample collected between October 2000 and August 2001. All concentrations were less than or equal to 0.20 micrograms per liter. The most frequently detected compounds in samples from Las Vegas Wash were caffeine, carbamazepine (used to treat epilepsy), cotinine (a metabolite of nicotine), and dehydronifedipine (a metabolite of the antianginal Procardia). Less frequently detected compounds in samples collected from Las Vegas Wash were antibiotics (clarithromycin, erythromycin, sulfamethoxazole, and trimethoprim), acetaminophen (an analgesic and anti-inflammatory), cimetidine (used to treat ulcers), codeine (a narcotic and analgesic), diltiazem (an antihypertensive), and 1,7-dimethylxanthine (a metabolite of caffeine). Fewer compounds were detected in samples collected from Lake Mead than from Las Vegas Wash. Caffeine was detected in all samples collected from Lake Mead. Other compounds detected in samples collected from Lake Mead were acetaminophen, carbamazepine, cotinine, 1,7-dimethylxanthine, and sulfamethoxazole.

Biomechanics and Biotensegrity: Study Method and Frequency Response of the Simplex and 3-bar-SVD Tensegrity Configurations

NASA Astrophysics Data System (ADS)

Castro Arenas, C.; Ghersi, I.; Miralles, M. T.

2016-04-01

The purpose of this work is to study the frequency response of 3D tensegrity structures. These are structures that have been used, since the 80’s, to model biological systems of different scales. This fact led to the origin of the field of biotensegrity, which includes biomechanics as a natural field of application. In this work: a) A simple method for the analysis of frequency response of different nodes in 3D tensegrity structures was set up and tuned. This method is based on a video-analysis algorithm, which was applied to the structures, as they were vibrated along their axis of symmetry, at frequencies from 1 Hz to 60 Hz. b) Frequency-response analyses were performed, for the simplest 3D structure, the Simplex module, as well as for two towers, formed by stacking two and three Simplex modules, respectively. Resonant frequencies were detected for the Simplex module at (19.2±0.1) Hz and (50.2±0.1) Hz (the latter being an average of frequencies between homologous nodes). For the towers with two and three modules, each selected node presented a characteristic frequency response, modulated by their spatial placement in each model. Resonances for the two-stage tower were found at: (12±0.1) Hz; (16.2±0.1) Hz; (29.4±0.1) Hz and (37.2±0.1) Hz. For the tower with three Simplex modules, the main resonant frequencies were found at (12.0±0.1) Hz and (21.0±0.1) Hz. Results show that the proposed method is adequate for the study (2D) of any 3D tensegrity structure, with the potential of being generalized to the study of oscillations in three dimensions. A growing complexity and variability in the frequency response of the nodes was observed, as modules were added to the structures. These findings were compared to those found in the available literature.

Reinterpreting Internalization and Agency through G. H. Mead's Perspectival Realism

ERIC Educational Resources Information Center

Martin, Jack

2006-01-01

Toward the end of his life, George Herbert Mead developed a theory of perspectives that may be used to reinterpret his social, developmental psychology. This paper attempts such a reinterpretation, leading to the emergence of a theory of perspective taking in early childhood that looks quite different from that which is assumed in most extant work…

36 CFR 7.48 - Lake Mead National Recreation Area.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Lake Mead National Recreation Area. 7.48 Section 7.48 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE... watercraft at a speed in excess of flat wake speed within 200 feet of any beach occupied by bathers, boats at...

36 CFR 7.48 - Lake Mead National Recreation Area.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Lake Mead National Recreation Area. 7.48 Section 7.48 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE... watercraft at a speed in excess of flat wake speed within 200 feet of any beach occupied by bathers, boats at...

36 CFR 7.48 - Lake Mead National Recreation Area.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Lake Mead National Recreation Area. 7.48 Section 7.48 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE... watercraft at a speed in excess of flat wake speed within 200 feet of any beach occupied by bathers, boats at...

36 CFR 7.48 - Lake Mead National Recreation Area.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Lake Mead National Recreation Area. 7.48 Section 7.48 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE... watercraft at a speed in excess of flat wake speed within 200 feet of any beach occupied by bathers, boats at...

36 CFR 7.48 - Lake Mead National Recreation Area.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Lake Mead National Recreation Area. 7.48 Section 7.48 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE... watercraft at a speed in excess of flat wake speed within 200 feet of any beach occupied by bathers, boats at...

Revolution and Counter-Revolution: Network Mobilization to Preserve Public Education in Wisconsin

ERIC Educational Resources Information Center

Kelley, Carolyn; Mead, Julie

2017-01-01

In this article, Kelley and Mead consider changes in the policymaking process in Wisconsin before the election of Governor Walker, in the early years following his election, and in the months preceding passage of the 2015-17 biennial budget. Kelley and Mead argue that in Wisconsin, serious and significant attacks to public education motivated by…

AmeriFlux US-Ne3 Mead - rainfed maize-soybean rotation site

DOE Data Explorer

Suyker, Andy [University of Nebraska - Lincoln

2016-01-01

This is the AmeriFlux version of the carbon flux data for the site US-Ne3 Mead - rainfed maize-soybean rotation site. Site Description - The study site is one of three fields (all located within 1.6 km of each other) at the University of Nebraska Agricultural Research and Development Center near Mead, Nebraska. While the other two sites are equipped with irrigation systems, this site relies on rainfall. A tillage operation (disking) was done just prior to the 2001 planting to homogenize the top 0.1 m of soil, incorporate P and K fertilizers, as well as previously accumulated surface residues. Since initiation of the study in 2001, this site has been under no-till management.

George Herbert Mead and the Allen controversy at the University of Wisconsin.

PubMed

Cook, Gary A

2007-01-01

This essay uses previously unpublished correspondence of George Herbert Mead to tell the story of his involvement in the aftermath of a political dispute that took place at the University of Wisconsin during the years 1914-1915. It seeks thereby to clarify the historical significance of an article he published on this controversy in late 1915. Taken together with relevant information about the educational activities of William H. Allen of the New York Bureau of Municipal Research, Mead's correspondence and article throw helpful light upon his understanding of how an educational survey of a university should proceed; they also show how he went about the task of evaluating a failed attempt at such a survey. (c) 2007 Wiley Periodicals, Inc.

Community Environmental Response Facilitation Act (CERFA) report, Fort George G. Mead, Maryland. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schultheisz, D.; Ward, L.

1994-04-01

This report presents the results of the Community Environmental Response Facilitation Act (CERFA) investigation conducted by Environmental Resources Management (ERM) at Fort George G. Meade (FGGM), a U.S. Government property selected for closure by the Base Realignment and Closure (BRAC) Commission. Under CERFA, Federal agencies are required to expeditiously identify real property that can be immediately reused and redeveloped. Satisfying this objective requires the identification of real property where no hazardous substances or petroleum products, regulated by the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), were stored for one year or more, known to have been released, or disposed.more » Fort George G. Meade, CERFA, Base closure, BRAC.« less

Mars Entry Atmospheric Data System Modeling, Calibration, and Error Analysis

NASA Technical Reports Server (NTRS)

Karlgaard, Christopher D.; VanNorman, John; Siemers, Paul M.; Schoenenberger, Mark; Munk, Michelle M.

2014-01-01

The Mars Science Laboratory (MSL) Entry, Descent, and Landing Instrumentation (MEDLI)/Mars Entry Atmospheric Data System (MEADS) project installed seven pressure ports through the MSL Phenolic Impregnated Carbon Ablator (PICA) heatshield to measure heatshield surface pressures during entry. These measured surface pressures are used to generate estimates of atmospheric quantities based on modeled surface pressure distributions. In particular, the quantities to be estimated from the MEADS pressure measurements include the dynamic pressure, angle of attack, and angle of sideslip. This report describes the calibration of the pressure transducers utilized to reconstruct the atmospheric data and associated uncertainty models, pressure modeling and uncertainty analysis, and system performance results. The results indicate that the MEADS pressure measurement system hardware meets the project requirements.

A new robust algorithm for computation of a triangle circumscribed sphere in E3 and a hypersphere simplex

NASA Astrophysics Data System (ADS)

Skala, Vaclav

2016-06-01

There are many applications in which a bounding sphere containing the given triangle E3 is needed, e.g. fast collision detection, ray-triangle intersecting in raytracing etc. This is a typical geometrical problem in E3 and it has also applications in computational problems in general. In this paper a new fast and robust algorithm of circumscribed sphere computation in the n-dimensional space is presented and specification for the E3 space is given, too. The presented method is convenient for use on GPU or with SSE or Intel's AVX instructions on a standard CPU.

Water Quality Monitoring for Lake Constance with a Physically Based Algorithm for MERIS Data.

PubMed

Odermatt, Daniel; Heege, Thomas; Nieke, Jens; Kneubühler, Mathias; Itten, Klaus

2008-08-05

A physically based algorithm is used for automatic processing of MERIS level 1B full resolution data. The algorithm is originally used with input variables for optimization with different sensors (i.e. channel recalibration and weighting), aquatic regions (i.e. specific inherent optical properties) or atmospheric conditions (i.e. aerosol models). For operational use, however, a lake-specific parameterization is required, representing an approximation of the spatio-temporal variation in atmospheric and hydrooptic conditions, and accounting for sensor properties. The algorithm performs atmospheric correction with a LUT for at-sensor radiance, and a downhill simplex inversion of chl-a, sm and y from subsurface irradiance reflectance. These outputs are enhanced by a selective filter, which makes use of the retrieval residuals. Regular chl-a sampling measurements by the Lake's protection authority coinciding with MERIS acquisitions were used for parameterization, training and validation.

Registration of interferometric SAR images

NASA Technical Reports Server (NTRS)

Lin, Qian; Vesecky, John F.; Zebker, Howard A.

1992-01-01

Interferometric synthetic aperture radar (INSAR) is a new way of performing topography mapping. Among the factors critical to mapping accuracy is the registration of the complex SAR images from repeated orbits. A new algorithm for registering interferometric SAR images is presented. A new figure of merit, the average fluctuation function of the phase difference image, is proposed to evaluate the fringe pattern quality. The process of adjusting the registration parameters according to the fringe pattern quality is optimized through a downhill simplex minimization algorithm. The results of applying the proposed algorithm to register two pairs of Seasat SAR images with a short baseline (75 m) and a long baseline (500 m) are shown. It is found that the average fluctuation function is a very stable measure of fringe pattern quality allowing very accurate registration.

UMCS feasibility study for Fort George G. Meade. Volume 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1996-12-01

Fort George G. Meade selected eighty-three (83) buildings, from the approximately 1,500 buildings on the base to be included in the UMCS Feasibility Study. The purpose of the study is to evaluate the feasibility of replacing the existing analog based Energy Monitoring and Control System (EMCS) with a new distributed process Monitoring and Control System (UMCS).

UMCS feasibility study for Fort George G. Meade volume 1. Feasibility study

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1996-12-01

Fort George G. Meade selected 83 buildings, from the approximately 1,500 buildings on the base to be included in the UMCS Feasibility Study. The purpose of the study is to evaluate the feasibility of replacing the existing analog based Energy Monitoring and Control System (EMCS) with a new distributed process Monitoring and Control System (UMCS).

Reproductive Responses of Common Carp Cyprinus carpio in Cages to Influent of the Las Vegas Wash in Lake Mead, Nevada, from late Winter to early Spring

EPA Science Inventory

To investigate the potential for contaminants in Las Vegas Wash (LW) influent to produce effects indicative of endocrine disruption in vivo, adult male and female common carp were exposed in cages for 42-48 d at four sites and two reference locations in Lake Mead.

Staff Ride Handbook for the Overland Campaign, Virginia, 4 May to 15 June 1864: A Study on Operational-Level Command

DTIC Science & Technology

2005-01-01

gives a needed feel for the tragedy of war. In short, staff ride leaders must choose a limited number of tactical details and human-interest stories...adjutant, was a Seneca Indian. 315 4. Meade, often irritable, was particularly frustrated at Cold Harbor. Although Meade did not publicly voice his

MERCURY CONCENTRATIONS IN SKELETAL MUSCLE OF FISH FROM LAKE MEAD, USA, RELATED TO FISH SIZE, CONDITION, TROPHIC LEVEL, LOCATION, AND CONSUMPTION RISK

EPA Science Inventory

In this first large-scale study of mercury (Hg) in Lake Mead, USA, the nation's largest man-
made reservoir, total-Hg concentrations were determined in the skeletal muscle of 339 fish collected during the Fall of 1998 and the Spring of 1999. Five species of fish representing ...

Publications - GMC 350 | Alaska Division of Geological & Geophysical

Science.gov Websites

in the NPRA, Alaska as follows: Ikpikpuk #1 core, cuttings, and sidewall core; South Meade #1 cuttings; Brontosaurus #1 cuttings and core; Walakpa #1 core; and Walakpa #2 cuttings and core Authors follows: Ikpikpuk #1 core, cuttings, and sidewall core; South Meade #1 cuttings; Brontosaurus #1 cuttings

The astrological roots of mesmerism.

PubMed

Schaffer, Simon

2010-06-01

Franz Anton Mesmer's 1766 thesis on the influence of the planets on the human body, in which he first publicly presented his account of the harmonic forces at work in the microcosm, was substantially copied from the London physician Richard Mead's early eighteenth century tract on solar and lunar effects on the body. The relation between the two texts poses intriguing problems for the historiography of medical astrology: Mesmer's use of Mead has been taken as a sign of the Vienna physician's enlightened modernity while Mead's use of astro-meteorology has been seen as evidence of the survival of antiquated astral medicine in the eighteenth century. Two aspects of this problem are discussed. First, French critics of mesmerism in the 1780s found precedents for animal magnetism in the work of Paracelsus, Fludd and other early modern writers; in so doing, they began to develop a sophisticated history for astrology and astro-meteorology. Second, the close relations between astro-meteorology and Mead's project illustrate how the environmental medical programmes emerged. The making of a history for astrology accompanied the construction of various models of the relation between occult knowledge and its contexts in the enlightenment.

Signal detection theory and vestibular perception: III. Estimating unbiased fit parameters for psychometric functions.

PubMed

Chaudhuri, Shomesh E; Merfeld, Daniel M

2013-03-01

Psychophysics generally relies on estimating a subject's ability to perform a specific task as a function of an observed stimulus. For threshold studies, the fitted functions are called psychometric functions. While fitting psychometric functions to data acquired using adaptive sampling procedures (e.g., "staircase" procedures), investigators have encountered a bias in the spread ("slope" or "threshold") parameter that has been attributed to the serial dependency of the adaptive data. Using simulations, we confirm this bias for cumulative Gaussian parametric maximum likelihood fits on data collected via adaptive sampling procedures, and then present a bias-reduced maximum likelihood fit that substantially reduces the bias without reducing the precision of the spread parameter estimate and without reducing the accuracy or precision of the other fit parameters. As a separate topic, we explain how to implement this bias reduction technique using generalized linear model fits as well as other numeric maximum likelihood techniques such as the Nelder-Mead simplex. We then provide a comparison of the iterative bootstrap and observed information matrix techniques for estimating parameter fit variance from adaptive sampling procedure data sets. The iterative bootstrap technique is shown to be slightly more accurate; however, the observed information technique executes in a small fraction (0.005 %) of the time required by the iterative bootstrap technique, which is an advantage when a real-time estimate of parameter fit variance is required.

AmeriFlux US-Ne2 Mead - irrigated maize-soybean rotation site

DOE Data Explorer

Suyker, Andy [University of Nebraska - Lincoln

2016-01-01

This is the AmeriFlux version of the carbon flux data for the site US-Ne2 Mead - irrigated maize-soybean rotation site. Site Description - The study site is one of three fields (all located within 1.6 km of each other) at the University of Nebraska Agricultural Research and Development Center near Mead, Nebraska. This site is irrigated with a center pivot system. Prior to the initiation of the study, the irrigated site had a 10-yr history of maize-soybean rotation under no-till. A tillage operation (disking) was done just prior to the 2001 planting to homogenize the top 0.1 m of soil, incorporate P and K fertilizers, as well as previously accumulated surface residues. Since this tillage operation, the site has been under no-till management.

View of Lake Mead and Las Vegas, Nevada area from Sklyab

NASA Image and Video Library

1973-08-01

SL3-28-059 (July-September 1973) --- A vertical view of the Lake Mead and Las Vegas, Nevada area as photographed from Earth orbit by one of the six lenses of the Itek-furnished S190-A Multispectral Photographic Facility Experiment aboard the Skylab space station. Lake Mead is water of the Colorado River impounded by Hoover Dam. Most of the land in the picture is Nevada. However, a part of the northwest corner of Arizona can be seen. Federal agencies participating with NASA on the EREP project are the Departments of Agriculture, Commerce, Interior, the Environmental Protection Agency and the Corps of Engineers. All EREP photography is available to the public through the Department of Interior?s Earth Resources Observations Systems Data Center, Sioux Falls, South Dakota, 57198. Photo credit: NASA

The Role of Trans Tensional Structures and Lake Mead Reservoir in Groundwater Flow in Black Canyon, Lake Mead National Recreation Area, NV-AZ

NASA Astrophysics Data System (ADS)

Justet, L.; Beard, S.

2010-12-01

Hot springs and seeps discharging into Black Canyon (BC) along the Colorado River in north Colorado River Valley (CRV) support endemic riparian ecosystems in the Lake Mead National Recreation Area. Increases in groundwater development in southern NV and northwestern AZ may impact spring discharge. Sources of spring discharge in BC were evaluated using geochemical methods. Kinematic analysis and geologic mapping of structures associated with BC springs were used to evaluate structural controls on groundwater flow in BC. Geochemical analysis indicates groundwater discharge near Hoover Dam (HD) and along the faulted edge of the Boulder City Pluton is derived from Lake Mead, high δ87Sr Proterozoic or Tertiary crystalline rock and, possibly, Tertiary sedimentary rock. Reducing conditions indicated by 234U/238U and δ34S concentrations suggest the groundwater is confined and/or derived from greater depths while carbon isotopes indicate the groundwater is old. Lighter δD and δO-18, modern tritium concentrations, post-Dam U disequilibrium ages, and occurrence of anthropogenic perchlorate support the presence of a young Lake Mead component. South of the pluton, the Lake Mead component is absent. More oxidizing conditions in this part of BC, indicated by the U and S isotope concentrations, suggest the groundwater is less confined and/or derived from shallower depths compared to groundwater discharging near HD. Older apparent groundwater ages and heavier δD and δO-18 values south of the pluton indicate slower flow paths from a lower elevation or latitude source. Clarifying the nature of groundwater flow in eastern NV, the analyses indicate that hydraulic connection between the regional carbonate aquifer and BC is unlikely. Instead, the data indicate sources of BC springs are derived relatively locally in CRV and, possibly, south Lake Mead Valley. Results of the geologic and kinematic analyses indicate faults that formed from the interaction of E-W extension related to the AZ extensional corridor and NW-SE trans tension related to the Lake Mead shear zone are the main controls on groundwater flow in the vicinity of HD and Boulder City Pluton. Most groundwater in BC appears to discharge along the NW-striking Palm Tree fault that parallels the northern edge of the pluton. Supported by trends in chemistry, an alignment of similar-elevation springs along a N-S striking fault that extends the length of west BC may be a flow path for groundwater from north BC to south of the pluton. South of the pluton, dikes intrude many of the faults and appear to act as flow barriers. Groundwater in this part of BC may flow through stacked layers of brecciated volcanic rock prevalent in the area. Flow from laterally adjacent valleys into BC would have to cross a N-S structural fabric that is not favored kinematically. Existing information implies an overall absence of significant surface discharge in BC prior to construction of HD. This indicates that the head created by impoundment of the Colorado River has likely pushed old, slow moving groundwater through CRV and, possibly, south Lake Mead Valley, to the surface in BC where it discharges as springs and seeps.

Fast intersection detection algorithm for PC-based robot off-line programming

NASA Astrophysics Data System (ADS)

Fedrowitz, Christian H.

1994-11-01

This paper presents a method for fast and reliable collision detection in complex production cells. The algorithm is part of the PC-based robot off-line programming system of the University of Siegen (Ropsus). The method is based on a solid model which is managed by a simplified constructive solid geometry model (CSG-model). The collision detection problem is divided in two steps. In the first step the complexity of the problem is reduced in linear time. In the second step the remaining solids are tested for intersection. For this the Simplex algorithm, which is known from linear optimization, is used. It computes a point which is common to two convex polyhedra. The polyhedra intersect, if such a point exists. Regarding the simplified geometrical model of Ropsus the algorithm runs also in linear time. In conjunction with the first step a resultant collision detection algorithm is found which requires linear time in all. Moreover it computes the resultant intersection polyhedron using the dual transformation.

Delusions of Liberty: Rethinking Democracy Promotion in American Grand Strategy

DTIC Science & Technology

2016-06-01

States’ first debates surrounding intervention in support of democratic uprisings. Edward Mead Earle describes American sentiment in 1821: “All educated...theories regarding human or state behavior are not unconditional or absolute in 3 Edward Mead ...property and to punish those who tread upon the rights of others.40 Thomas Jefferson’s rationale of popular revolt against King George III’s rule

Collecting to Win: ISR for Strategic Effect

DTIC Science & Technology

2014-02-13

Cryptologic History (Ft. George G. Meade , MD: National Security Agency, 1992), 1-143; Matthew M. Aid, The Secret Sentry: The Untold History of the National...United States Cryptologic History. Ft. George G. Meade , MD: National Security Agency, 1992. Norris, Pat. Spies in the Sky: Surveillance Satellites in...Submitted to the Faculty In Partial Fulfillment of the Graduation Requirements Advisor: Dr. Herbert L. Frandsen, Jr. 13 February 2014

Publications - GMC 299 | Alaska Division of Geological & Geophysical

Science.gov Websites

conventional NPRA core samples from the following wells: U.S. Navy Meade T. W. #1 (600'-2366'); Husky Oil NPR Operations North Kalikpik T. W. #1 (6992.5'); and Husky Oil NPR Operations Seabee T. W. #1 (6547.6' and wells: U.S. Navy Meade T. W. #1 (600'-2366'); Husky Oil NPR Operations North Kalikpik T. W. #1 (6992.5

Competing risks and the development of adaptive management plans for water resources: Field reconnaissance investigation of risks to fishes and other aquatic biota exposed to endocrine disrupting chemicals (edcs) in lake mead, Nevada USA

USGS Publications Warehouse

Linder, G.; Little, E.E.

2009-01-01

The analysis and characterization of competing risks for water resources rely on a wide spectrum of tools to evaluate hazards and risks associated with their management. For example, waters of the lower Colorado River stored in reservoirs such as Lake Mead present a wide range of competing risks related to water quantity and water quality. These risks are often interdependent and complicated by competing uses of source waters for sustaining biological resources and for supporting a range of agricultural, municipal, recreational, and industrial uses. USGS is currently conducting a series of interdisciplinary case-studies on water quality of Lake Mead and its source waters. In this case-study we examine selected constituents potentially entering the Lake Mead system, particularly endocrine disrupting chemicals (EDCs). Worldwide, a number of environmental EDCs have been identified that affect reproduction, development, and adaptive behaviors in a wide range of organisms. Many EDCs are minimally affected by current treatment technologies and occur in treated sewage effluents. Several EDCs have been detected in Lake Mead, and several substances have been identified that are of concern because of potential impacts to the aquatic biota, including the sport fishery of Lake Mead and endangered razorback suckers (Xyrauchen texanus) that occur in the Colorado River system. For example, altered biomarkers relevant to reproduction and thyroid function in fishes have been observed and may be predictive of impaired metabolism and development. Few studies, however, have addressed whether such EDC-induced responses observed in the field have an ecologically significant effect on the reproductive success of fishes. To identify potential linkages between EDCs and species of management concern, the risk analysis and characterization in this reconnaissance study focused on effects (and attendant uncertainties) that might be expressed by exposed populations. In addition, risk reduction measures that may be of interest to resource managers are considered relative to emerging contaminants in treated effluents, interdependencies among biological resources at risk, and uses of reservoir waters derived from multiple inflows of widely varying qualities. ??2009 ASCE.

Immunophotoaffinity labeling of binders of 1-methyladenine, the oocyte maturation-inducing hormone of starfish

DOE Office of Scientific and Technical Information (OSTI.GOV)

Toraya, Tetsuo; Kida, Tetsuo; Kuyama, Atsushi

Starfish oocytes are arrested at the prophase stage of the first meiotic division in the ovary and resume meiosis by the stimulus of 1-methyladenine (1-MeAde), the oocyte maturation-inducing hormone of starfish. Putative 1-MeAde receptors on the oocyte surface have been suggested, but not yet been biochemically characterized. Immunophotoaffinity labeling, i.e., photoaffinity labeling combined with immunochemical detection, was attempted to detect unknown 1-MeAde binders including putative maturation-inducing hormone receptors in starfish oocytes. When the oocyte crude membrane fraction or its Triton X-100/EDTA extract was incubated with N{sup 6}-[6-(5-azido-2-nitrobenzoyl)aminohexyl]carboxamidomethyl-1-methyladenine and then photo-irradiated, followed by western blotting with antibody that was raised againstmore » a 1-MeAde hapten, a single band with M{sub r} of 47.5 K was detected. The band was lost when extract was heated at 100 °C. A similar 47.5 K band was detected in the crude membrane fraction of testis as well. Upon labeling with whole cells, this band was detected in immature and maturing oocytes, but only faintly in mature oocytes. As judged from these results, this 1-MeAde binder might be a possible candidate of the starfish maturation-inducing hormone receptors. - Highlights: • Synthesis of photoaffinity labeling reagents for 1-methyladenine binders of starfish. • Immunochemical detection of photoaffinity-labeled 1-methyladenine binders. • Immunophotoaffinity labeling of a 47.5 K 1-methyladenine binder in oocytes and testis. • A possible candidate of oocyte maturation-inducing hormone receptors of starfish.« less

Sources and distribution of organic compounds using passive samplers in Lake Mead national recreation area, Nevada and Arizona, and their implications for potential effects on aquatic biota.

PubMed

Rosen, Michael R; Alvarez, David A; Goodbred, Steven L; Leiker, Thomas J; Patiño, Reynaldo

2010-01-01

The delineation of lateral and vertical gradients of organic contaminants in lakes is hampered by low concentrationsand nondetection of many organic compounds in water. Passive samplers (semipermeable membrane devices [SPMDs] and polar organic chemical integrative samplers [POCIS]) are well suited for assessing gradients because they can detect synthetic organic compounds (SOCs) at pg L(-1) concentrations. Semi-permeable membrane devices and POCIS were deployed in Lake Mead, at two sites in Las Vegas Wash, at four sites across Lake Mead, and in the Colorado River downstream from Hoover Dam. Concentrations of hydrophobic SOCs were highest in Las Vegas Wash downstream from waste water and urban inputs and at 8 m depth in Las Vegas Bay (LVB) where Las Vegas Wash enters Lake Mead. The distribution of hydrophobic SOCs showed a lateral distribution across 10 km of Lake Mead from LVB to Boulder Basin. To assess possible vertical gradient SOCs, SPMDs were deployed at 4-m intervals in 18 m of water in LVB. Fragrances and legacy SOCs were found at the greatest concentrations at the deepest depth. The vertical gradient of SOCs indicated that contaminants were generally confined to within 6 m of the lake bottom during the deployment interval. The high SOC concentrations, warmer water temperatures, and higher total dissolved solids concentrations at depth are indicative of a plume of Las Vegas Wash water moving along the lake bottom. The lateral and vertical distribution of SOCs is discussed in the context of other studies that have shown impaired health of fish exposed to SOCs.

The construction of mind, self, and society: the social process behind G. H. Mead'S social psychology.

PubMed

Huebner, Daniel R

2012-01-01

Mind, Self, and Society, the posthumously published volume by which George Herbert Mead is primarily known, poses acute problems of interpretation so long as scholarship does not consider the actual process of its construction. This paper utilizes extensive archival correspondence and notes in order to analyze this process in depth. The analysis demonstrates that the published form of the book is the result of a consequential interpretive process in which social actors manipulated textual documents within given practical constraints over a course of time. The paper contributes to scholarship on Mead by indicating how this process made possible certain understandings of his social psychology and by relocating the materials that make up the single published text within the disparate contexts from which they were originally drawn. © 2012 Wiley Periodicals, Inc.

Sikuliqiruq: Ice dynamics of the Meade river - Arctic Alaska, from freezeup to breakup from time-series ground imagery

USGS Publications Warehouse

Beck, R.A.; Rettig, A.J.; Ivenso, C.; Eisner, Wendy R.; Hinkel, Kenneth M.; Jones, Benjamin M.; Arp, C.D.; Grosse, G.; Whiteman, D.

2010-01-01

Ice formation and breakup on Arctic rivers strongly influence river flow, sedimentation, river ecology, winter travel, and subsistence fishing and hunting by Alaskan Natives. We use time-series ground imagery ofthe Meade River to examine the process at high temporal and spatial resolution. Freezeup from complete liquid cover to complete ice cover ofthe Meade River at Atqasuk, Alaska in the fall of 2008 occurred in less than three days between 28 September and 2 October 2008. Breakup in 2009 occurred in less than two hours between 23:47 UTC on 23 May 2009 and 01:27 UTC on 24 May 2009. All times in UTC. Breakup in 2009 and 2010 was ofthe thermal style in contrast to the mechanical style observed in 1966 and is consistent with a warming Arctic. ?? 2010 Taylor & Francis.

Astronaut Carl Meade mans pilots station during trajectory control exercise

NASA Image and Video Library

1994-09-12

STS064-22-024 (9-20 Sept. 1994) --- With a manual and lap top computer in front of him, astronaut Carl J. Meade, STS-64 mission specialist, supports operations with the Trajectory Control Sensor (TCS) aboard the Earth-orbiting space shuttle Discovery. For this exercise, Meade temporarily mans the pilot's station on the forward flight deck. The TCS is the work of a team of workers at NASA's Johnson Space Center. Data gathered during this flight was expected to prove valuable in designing and developing a sensor for use during the rendezvous and mating phases of orbiter missions to the space station. For this demonstration, the Shuttle Pointed Autonomous Research Tool for Astronomy 201 (SPARTAN 201) was used as the target vehicle during release and retrieval operations. Photo credit: NASA or National Aeronautics and Space Administration

Can Linear Superiorization Be Useful for Linear Optimization Problems?

PubMed Central

Censor, Yair

2017-01-01

Linear superiorization considers linear programming problems but instead of attempting to solve them with linear optimization methods it employs perturbation resilient feasibility-seeking algorithms and steers them toward reduced (not necessarily minimal) target function values. The two questions that we set out to explore experimentally are (i) Does linear superiorization provide a feasible point whose linear target function value is lower than that obtained by running the same feasibility-seeking algorithm without superiorization under identical conditions? and (ii) How does linear superiorization fare in comparison with the Simplex method for solving linear programming problems? Based on our computational experiments presented here, the answers to these two questions are: “yes” and “very well”, respectively. PMID:29335660

Can linear superiorization be useful for linear optimization problems?

NASA Astrophysics Data System (ADS)

Censor, Yair

2017-04-01

Linear superiorization (LinSup) considers linear programming problems but instead of attempting to solve them with linear optimization methods it employs perturbation resilient feasibility-seeking algorithms and steers them toward reduced (not necessarily minimal) target function values. The two questions that we set out to explore experimentally are: (i) does LinSup provide a feasible point whose linear target function value is lower than that obtained by running the same feasibility-seeking algorithm without superiorization under identical conditions? (ii) How does LinSup fare in comparison with the Simplex method for solving linear programming problems? Based on our computational experiments presented here, the answers to these two questions are: ‘yes’ and ‘very well’, respectively.

Technical Report for Proposed Ordnance Clearance at Fort George G. Meade

DTIC Science & Technology

1991-03-01

Potomac Group (including the Patapsco, Arundel Clay, and Patuxent Formations), the Magothy Formation and the Patuxent River terraces and associated...alluvium. The youngest geologic unit in theI stratigraphic sequence underlying Fort Meade is the Magothy Formation of Late Cretaceous age. This formation...Department of the Army, 1981). The Magothy Formation unconformably overlies the sediments of the Lower Cretaceous Potomac Group. i The formations of the

Kinetics of selenium release in mine waste from the Meade Peak Phosphatic Shale, Phosphoria Formation, Wooley Valley, Idaho, USA

Treesearch

Lisa L. Stillings; Michael C. Amacher

2010-01-01

Phosphorite from the Meade Peak Phosphatic Shale member of the Permian Phosphoria Formation has been mined in southeastern Idaho since 1906. Dumps of waste rock from mining operations contain high concentrations of Se which readily leach into nearby streams and wetlands. While the most common mineralogical residence of Se in the phosphatic shale is elemental Se, Se(0...

Radioactive cesium isotope ratios as a tool for determining dispersal and re-dispersal mechanisms downwind from the Nevada Nuclear Security Site.

PubMed

Snyder, Darin C; Delmore, James E; Tranter, Troy; Mann, Nick R; Abbott, Michael L; Olson, John E

2012-08-01

Fractionation of the two longer-lived radioactive cesium isotopes ((135)Cs and (137)Cs) produced by above ground nuclear tests have been measured and used to clarify the dispersal mechanisms of cesium deposited in the area between the Nevada Nuclear Security Site and Lake Mead in the southwestern United States. Fractionation of these isotopes is due to the 135-decay chain requiring several days to completely decay to (135)Cs, and the 137-decay chain less than one hour decay to (137)Cs. Since the Cs precursors are gases, iodine and xenon, the (135)Cs plume was deposited farther downwind than the (137)Cs plume. Sediment core samples were obtained from the Las Vegas arm of Lake Mead, sub-sampled and analyzed for (135)Cs/(137)Cs ratios by thermal ionization mass spectrometry. The layers proved to have nearly identical highly fractionated isotope ratios. This information is consistent with a model where the cesium was initially deposited onto the land area draining into Lake Mead and the composite from all of the above ground shots subsequently washed onto Lake Mead by high intensity rain and wind storms producing a layering of Cs activity, where each layer is a portion of the composite. Copyright © 2012 Elsevier Ltd. All rights reserved.

[The lysate and recombinant antigens in ELISA-test-systems for diagnostic of herpes simplex].

PubMed

Ganova, L A; Kovtoniuk, G V; Korshun, L N; Kiseleva, E K; Tereshchenko, M I; Vudmaska, M I; Moĭsa, L N; Shevchuk, V A; Spivak, N Ia

2014-08-01

The lysate and recombinant antigens of various production included informula of ELISA-test-systems were analyzed. The ELISA-test-systems are used for detection of IgG to Herpes simplex virus type I and II. For testing the panel of serums PTH 201 (BBI Inc.) were used. The samples of this panel contain antibodies to Herpes simplex virus type I and II in mixed titers. The 69 serums of donors were used too (17 samples had IgG to Herpes simplex virus type I, 23 samples to Herpes simplex virus type II and 29 samples had no antibodies to Herpes simplex virus). The diagnostic capacity of mixture of recombinant antigens gG1 Herpes simplex virus type I and gG2 Herpes simplex virus type II (The research-and-production complex "DiaprofMed") was comparable with mixture of lysate antigen Herpes simplex virus type I and II (Membrane) EIE Antigen ("Virion Ltd."). In the test-systems for differentiation of IgG to Herpes simplex virus type I the recombinant antigen gG1 Herpes simplex virus type I proved to be comparable with commercial analogue Herpes simplex virus-1 gG1M ("Viral Therapeutics Inc."'). At the same time, capacity to detect IgG to Herpes simplex virus type II in recombinant protein gG2 Herpes simplex virus type II is significantly higher than in its analogue Herpes simplex virus-2 gG2c ("Viral Therapeutics Inc.").

The Significance of Herpes Simplex for School Nurses

ERIC Educational Resources Information Center

Ensor, Deirdre

2005-01-01

Herpes simplex is a common recurrent viral infection caused by the herpes simplex virus. The two closely related but distinct viruses that cause herpes simplex infections are herpes simplex 1 (HSV-1) and herpes simplex 2 (HSV-2). HSV-1 is commonly associated with infections around the oral mucosa and is the cause of herpes labialis, often referred…

Can mutational GC-pressure create new linear B-cell epitopes in herpes simplex virus type 1 glycoprotein B?

PubMed

Khrustalev, Vladislav Victorovich

2009-01-01

We showed that GC-content of nucleotide sequences coding for linear B-cell epitopes of herpes simplex virus type 1 (HSV1) glycoprotein B (gB) is higher than GC-content of sequences coding for epitope-free regions of this glycoprotein (G + C = 73 and 64%, respectively). Linear B-cell epitopes have been predicted in HSV1 gB by BepiPred algorithm ( www.cbs.dtu.dk/services/BepiPred ). Proline is an acrophilic amino acid residue (it is usually situated on the surface of protein globules, and so included in linear B-cell epitopes). Indeed, the level of proline is much higher in predicted epitopes of gB than in epitope-free regions (17.8% versus 1.8%). This amino acid is coded by GC-rich codons (CCX) that can be produced due to nucleotide substitutions caused by mutational GC-pressure. GC-pressure will also lead to disappearance of acrophobic phenylalanine, isoleucine, methionine and tyrosine coded by GC-poor codons. Results of our "in-silico directed mutagenesis" showed that single nonsynonymous substitutions in AT to GC direction in two long epitope-free regions of gB will cause formation of new linear epitopes or elongation of previously existing epitopes flanking these regions in 25% of 539 possible cases. The calculations of GC-content and amino acid content have been performed by CodonChanges algorithm ( www.barkovsky.hotmail.ru ).

Non-nucleosidic inhibition of Herpes simplex virus DNA polymerase: mechanistic insights into the anti-herpetic mode of action of herbal drug withaferin A.

PubMed

Grover, Abhinav; Agrawal, Vibhuti; Shandilya, Ashutosh; Bisaria, Virendra S; Sundar, Durai

2011-01-01

Herpes Simplex Virus 1 and 2 causes several infections in humans including cold sores and encephalitis. Previous antiviral studies on herpes viruses have focussed on developing nucleoside analogues that can inhibit viral polymerase and terminate the replicating viral DNA. However, these drugs bear an intrinsic non-specificity as they can also inhibit cellular polymerase apart from the viral one. The present study is an attempt to elucidate the action mechanism of naturally occurring withaferin A in inhibiting viral DNA polymerase, thus providing an evidence for its development as a novel anti-herpetic drug. Withaferin A was found to bind very similarly to that of the previously reported 4-oxo-DHQ inhibitor. Withaferin A was observed binding to the residues Gln 617, Gln 618, Asn 815 and Tyr 818, all of which are crucial to the proper functioning of the polymerase. A comparison of the conformation obtained from docking and the molecular dynamics simulations shows that substantial changes in the binding conformations have occurred. These results indicate that the initial receptor-ligand interaction observed after docking can be limited due to the receptor rigid docking algorithm and that the conformations and interactions observed after simulation runs are more energetically favoured. We have performed docking and molecular dynamics simulation studies to elucidate the binding mechanism of prospective herbal drug withaferin A onto the structure of DNA polymerase of Herpes simplex virus. Our docking simulations results give high binding affinity of the ligand to the receptor. Long de novo MD simulations for 10 ns performed allowed us to evaluate the dynamic behaviour of the system studied and corroborate the docking results, as well as identify key residues in the enzyme-inhibitor interactions. The present MD simulations support the hypothesis that withaferin A is a potential ligand to target/inhibit DNA polymerase of the Herpes simplex virus. Results of these studies will also guide the design of selective inhibitors of DNA POL with high specificity and potent activity in order to strengthen the therapeutic arsenal available today against the dangerous biological warfare agent represented by Herpes Simplex Virus.

Non-nucleosidic inhibition of Herpes simplex virus DNA polymerase: mechanistic insights into the anti-herpetic mode of action of herbal drug withaferin A

PubMed Central

2011-01-01

Background Herpes Simplex Virus 1 and 2 causes several infections in humans including cold sores and encephalitis. Previous antiviral studies on herpes viruses have focussed on developing nucleoside analogues that can inhibit viral polymerase and terminate the replicating viral DNA. However, these drugs bear an intrinsic non-specificity as they can also inhibit cellular polymerase apart from the viral one. The present study is an attempt to elucidate the action mechanism of naturally occurring withaferin A in inhibiting viral DNA polymerase, thus providing an evidence for its development as a novel anti-herpetic drug. Results Withaferin A was found to bind very similarly to that of the previously reported 4-oxo-DHQ inhibitor. Withaferin A was observed binding to the residues Gln 617, Gln 618, Asn 815 and Tyr 818, all of which are crucial to the proper functioning of the polymerase. A comparison of the conformation obtained from docking and the molecular dynamics simulations shows that substantial changes in the binding conformations have occurred. These results indicate that the initial receptor-ligand interaction observed after docking can be limited due to the receptor rigid docking algorithm and that the conformations and interactions observed after simulation runs are more energetically favoured. Conclusions We have performed docking and molecular dynamics simulation studies to elucidate the binding mechanism of prospective herbal drug withaferin A onto the structure of DNA polymerase of Herpes simplex virus. Our docking simulations results give high binding affinity of the ligand to the receptor. Long de novo MD simulations for 10 ns performed allowed us to evaluate the dynamic behaviour of the system studied and corroborate the docking results, as well as identify key residues in the enzyme-inhibitor interactions. The present MD simulations support the hypothesis that withaferin A is a potential ligand to target/inhibit DNA polymerase of the Herpes simplex virus. Results of these studies will also guide the design of selective inhibitors of DNA POL with high specificity and potent activity in order to strengthen the therapeutic arsenal available today against the dangerous biological warfare agent represented by Herpes Simplex Virus. PMID:22373101

Army Drug Development Program. Phase 1. Clinical Testing

DTIC Science & Technology

1981-02-01

drug administration, the subjects fasted from 2400 to 0600, at which time they were given 360 ml Sustacal (Mead Johnson product ...Such factors as time of day, meals, alcohol, other drugs, and lack of proper sleep may affect the level of drug in your blood on...Sustacal (Mead Johnson product ) containing a total of 360 calories. Subjects ingested a single oral 750 mg dose of WR 180,409•H3PO4 in

America’s Transitional Capacity: War, Systems, and Globalization

DTIC Science & Technology

2013-05-23

alleviate human suffering. Amartya Sen supports the Wilsonian philosophy by pointing out that 44Mead, 131. 45Ibid., 103. 46Mead, 164-7. 19...E. Fiasco: the American Military Adventure in Iraq, 2003 to 2005. Reprint ed. New York, NY: Penguin Books, 2007. Sen , Amartya . Development as...they produced a large naval forces in order to expand trade markets and ensure 47Amartya Sen , Development as Freedom (New York: Anchor Books, 1999

Assessing socially situated participation: a way of integrating communication and social assessment approaches.

PubMed

Duchan, J F

2000-01-01

We have long treated communication and social assessment as related but separate domains. Theorizing by George Herbert Mead on "the social self" offers an alternative to this conceptual separation and a means of evaluating children's social interaction, social participation, and communication simultaneously. This article describes Mead's thinking and presents a framework for assessing children's social reciprocity, interactive stances, and role participation as they participate in everyday life contexts.

Why UW: Factoring in the Decision Point for Unconventional Warfare

DTIC Science & Technology

2012-12-01

political, economic, ideological, and technological elements into the concept of strategy has existed since ancient times. See Edward Mead Earle...declassified CIA records. Irene Gendzier, states that “Known CIA agents Miles Copeland and Stephen Meade were directly involved in the Syria coup of 1947...State Herbert Hoover Jr. gave full approval.98 The only note of caution came later from the CIA operations chief, Frank Wisner, who insisted that no

Information diffusion, Facebook clusters, and the simplicial model of social aggregation: a computational simulation of simplicial diffusers for community health interventions.

PubMed

Kee, Kerk F; Sparks, Lisa; Struppa, Daniele C; Mannucci, Mirco A; Damiano, Alberto

2016-01-01

By integrating the simplicial model of social aggregation with existing research on opinion leadership and diffusion networks, this article introduces the constructs of simplicial diffusers (mathematically defined as nodes embedded in simplexes; a simplex is a socially bonded cluster) and simplicial diffusing sets (mathematically defined as minimal covers of a simplicial complex; a simplicial complex is a social aggregation in which socially bonded clusters are embedded) to propose a strategic approach for information diffusion of cancer screenings as a health intervention on Facebook for community cancer prevention and control. This approach is novel in its incorporation of interpersonally bonded clusters, culturally distinct subgroups, and different united social entities that coexist within a larger community into a computational simulation to select sets of simplicial diffusers with the highest degree of information diffusion for health intervention dissemination. The unique contributions of the article also include seven propositions and five algorithmic steps for computationally modeling the simplicial model with Facebook data.

One-Shot Learning of Human Activity With an MAP Adapted GMM and Simplex-HMM.

PubMed

Rodriguez, Mario; Orrite, Carlos; Medrano, Carlos; Makris, Dimitrios

2016-05-10

This paper presents a novel activity class representation using a single sequence for training. The contribution of this representation lays on the ability to train an one-shot learning recognition system, useful in new scenarios where capturing and labeling sequences is expensive or impractical. The method uses a universal background model of local descriptors obtained from source databases available on-line and adapts it to a new sequence in the target scenario through a maximum a posteriori adaptation. Each activity sample is encoded in a sequence of normalized bag of features and modeled by a new hidden Markov model formulation, where the expectation-maximization algorithm for training is modified to deal with observations consisting in vectors in a unit simplex. Extensive experiments in recognition have been performed using one-shot learning over the public datasets Weizmann, KTH, and IXMAS. These experiments demonstrate the discriminative properties of the representation and the validity of application in recognition systems, achieving state-of-the-art results.

Control Allocation with Load Balancing

NASA Technical Reports Server (NTRS)

Bodson, Marc; Frost, Susan A.

2009-01-01

Next generation aircraft with a large number of actuators will require advanced control allocation methods to compute the actuator commands needed to follow desired trajectories while respecting system constraints. Previously, algorithms were proposed to minimize the l1 or l2 norms of the tracking error and of the actuator deflections. The paper discusses the alternative choice of the l(infinity) norm, or sup norm. Minimization of the control effort translates into the minimization of the maximum actuator deflection (min-max optimization). The paper shows how the problem can be solved effectively by converting it into a linear program and solving it using a simplex algorithm. Properties of the algorithm are also investigated through examples. In particular, the min-max criterion results in a type of load balancing, where the load is th desired command and the algorithm balances this load among various actuators. The solution using the l(infinity) norm also results in better robustness to failures and to lower sensitivity to nonlinearities in illustrative examples.

A History of U.S. Military Conceptual Solutions to the Uncertainty of Expeditions

DTIC Science & Technology

2016-06-10

War I, the Army appointed COL Samuel D. Rockenbach as commandant of the Tank School in Camp Meade , Maryland.4 In this role, COL Rockenbach intended to...France, led by Captain George S. Patton, Jr., which proved prolific both in the extent to which it influenced American thinking regarding tanks and...Tank In 1928, Secretary of War Dwight Davis directed the Army to establish an experimental armored force at Camp Meade , Maryland. This experimental

Autohypnosis and Trance Dance in Bali.

PubMed

Haley, Jay; Richeport-Haley, Madeleine

2015-01-01

A masterpiece of historical importance, this paper recounts Jay and Madeleine Haley's trip to Bali nearly 50 years after Gregory Bateson and Margaret Mead first went there. The Haleys met several of the same individuals who greeted Bateson and Mead and made a film they entitled "Dance and Trance of Balinese Children." This is a fascinating document of a culture and society so different from our own and the technique of dance and trance used to regulate emotion and violence.

LEVELS OF SYNTHETIC MUSK COMPOUNDS IN ...

EPA Pesticide Factsheets

To test the ruggedness of a newly developed analytical method for synthetic musks, a 1-year monthly monitoring of synthetic musks in water and biota was conducted for LakeMead (near Las Vegas, Nevada) as well as for combined sewage-dedicated effluent streams feeding Lake Mead. Data obtained from analyses of combined effluent streams from three municipal sewage treatment plants, from the effluent-receiving lake water, and from whole carp (Cyprinus carpio) tissue, indicated bioconcentration of synthetic musks in carp (1400-4500 pg/g). That same data were evaluated for the prediction of levels of synthetic musk compounds in fish, using values from the source (sewage treatment plant effluent [STP]). This study confirmed the presence of polycyclic and nitro musks in STP effluent, Lake Mead water, and carp. The concentrations of the polycyclic and nitro musks found in Lake Mead carp were considerably lower than previous studies in Germany, other European countries, and Japan. The carp samples were found to have mostly the mono-amino-metabolites of the nitro musks and intact polycyclic musks, principally HHCB (Galaxolide®) and AHTN (Tonalide®). Finally, the determination of sufficiently high levels of Galaxolide® and 4-amino musk xylene in STP effluent may be used to infer the presence of trace levels of other classes of musk compounds in the lake water. To be presented is an overview of the chemistry, the monitoring methodology, andthe statistical evaluation of con

Site inspection addendum. Fort Meade feasibility study and remedial investigation/site inspection Fort George G. Meade, Maryland. Revision 1. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1995-12-01

This Site Inspection Addendum Report has been prepared to address the Site Inspection portion of the Feasibility Study (FS) and Remedial Investigation/Site Inspection (RI/SI) activities at Fort George G. Meade. It has been prepared under Delivery Order No. 009 and a Change Order dated July 15, 1993, for the U.S. Army Environmental Center (USAEC), formerly known as the U.S. Army Toxic and Hazardous Materials Agency (USATHAMA). This report fulfills the requirements of deliverable ELIN A004 under Delivery Order 0009 of the Total Environmental Program Support (TEPS) contract DAAAl5-91-D-00l6. The purpose of this Site Inspection Addendum (SIA) report is to reportmore » the findings of Arthur D. Little`s SIA investigation. The overall purpose of an SI is to evaluate if chemical releases or potential contamination has occurred at suspected sites and to determine if further investigation is warranted. This study is an addendum to a previous SI and addresses data gaps remaining from or identified in that document. Six sites at Fort George G. Meade (FGGM) are included in the SIA: DPDO Salvage Yard and Transform Storage Area; DPDO Salvage Yard and Transformer Storage Area; Fire Training Area; Helicopter Hangar Area; Inactive Landfill No. 2, Ordnance Demolition Area Soldiers Lake.« less

Size distributions and exposure concentrations of nanoparticles associated with the emissions of oil mists from fastener manufacturing processes.

PubMed

Wang, Ying-Fang; Tsai, Perng-Jy; Chen, Chun-Wan; Chen, Da-Ren; Dai, Yu-Tung

2011-12-30

The aims of the present study were set out to measure size distributions and estimate workers' exposure concentrations of oil mist nanoparticles in three selected workplaces of the forming, threading, and heat treating areas in a fastener manufacturing plant by using a modified electrical aerosol detector (MEAD). The results were further compared with those simultaneously obtained from a nanoparticle surface area monitor (NSAM) and a scanning mobility particle sizer (SMPS) for the validation purpose. Results show that oil mist nanoparticles in the three selected process areas were formed mainly through the evaporation and condensation processes. The measured size distributions of nanoparticles were consistently in the form of uni-modal. The estimated fraction of nanoparticles deposited on the alveolar (AV) region was consistently much higher than that on the head airway (HD) and tracheobronchial (TB) regions in both number and surface area concentration bases. However, a significant difference was found in the estimated fraction of nanoparticles deposited on each individual region while different exposure metrics were used. Comparable results were found between results obtained from both NSAM and MEAD. After normalization, no significant difference can be found between the results obtained from SMPS and MEAD. It is concluded that the obtained MEAD results are suitable for assessing oil mist nanoparticle exposures. Copyright © 2011 Elsevier B.V. All rights reserved.

Model based LV-reconstruction in bi-plane x-ray angiography

NASA Astrophysics Data System (ADS)

Backfrieder, Werner; Carpella, Martin; Swoboda, Roland; Steinwender, Clemens; Gabriel, Christian; Leisch, Franz

2005-04-01

Interventional x-ray angiography is state of the art in diagnosis and therapy of severe diseases of the cardiovascular system. Diagnosis is based on contrast enhanced dynamic projection images of the left ventricle. A new model based algorithm for three dimensional reconstruction of the left ventricle from bi-planar angiograms was developed. Parametric super ellipses are deformed until their projection profiles optimally fit measured ventricular projections. Deformation is controlled by a simplex optimization procedure. A resulting optimized parameter set builds the initial guess for neighboring slices. A three dimensional surface model of the ventricle is built from stacked contours. The accuracy of the algorithm has been tested with mathematical phantom data and clinical data. Results show conformance with provided projection data and high convergence speed makes the algorithm useful for clinical application. Fully three dimensional reconstruction of the left ventricle has a high potential for improvements of clinical findings in interventional cardiology.

Numerical Optimization Strategy for Determining 3D Flow Fields in Microfluidics

NASA Astrophysics Data System (ADS)

Eden, Alex; Sigurdson, Marin; Mezic, Igor; Meinhart, Carl

2015-11-01

We present a hybrid experimental-numerical method for generating 3D flow fields from 2D PIV experimental data. An optimization algorithm is applied to a theory-based simulation of an alternating current electrothermal (ACET) micromixer in conjunction with 2D PIV data to generate an improved representation of 3D steady state flow conditions. These results can be used to investigate mixing phenomena. Experimental conditions were simulated using COMSOL Multiphysics to solve the temperature and velocity fields, as well as the quasi-static electric fields. The governing equations were based on a theoretical model for ac electrothermal flows. A Nelder-Mead optimization algorithm was used to achieve a better fit by minimizing the error between 2D PIV experimental velocity data and numerical simulation results at the measurement plane. By applying this hybrid method, the normalized RMS velocity error between the simulation and experimental results was reduced by more than an order of magnitude. The optimization algorithm altered 3D fluid circulation patterns considerably, providing a more accurate representation of the 3D experimental flow field. This method can be generalized to a wide variety of flow problems. This research was supported by the Institute for Collaborative Biotechnologies through grant W911NF-09-0001 from the U.S. Army Research Office.

Lichen simplex chronicus

MedlinePlus

... lichen simplex chronicus; Atopic dermatitis - lichen simplex chronicus; Psoriasis - lichen simplex chronicus ... people who have: Skin allergies Eczema (atopic dermatitis) Psoriasis Nervousness, anxiety, depression, and other emotional problems The ...

The solution of the optimization problem of small energy complexes using linear programming methods

NASA Astrophysics Data System (ADS)

Ivanin, O. A.; Director, L. B.

2016-11-01

Linear programming methods were used for solving the optimization problem of schemes and operation modes of distributed generation energy complexes. Applicability conditions of simplex method, applied to energy complexes, including installations of renewable energy (solar, wind), diesel-generators and energy storage, considered. The analysis of decomposition algorithms for various schemes of energy complexes was made. The results of optimization calculations for energy complexes, operated autonomously and as a part of distribution grid, are presented.

Space mapping method for the design of passive shields

NASA Astrophysics Data System (ADS)

Sergeant, Peter; Dupré, Luc; Melkebeek, Jan

2006-04-01

The aim of the paper is to find the optimal geometry of a passive shield for the reduction of the magnetic stray field of an axisymmetric induction heater. For the optimization, a space mapping algorithm is used that requires two models. The first is an accurate model with a high computational effort as it contains finite element models. The second is less accurate, but it has a low computational effort as it uses an analytical model: the shield is replaced by a number of mutually coupled coils. The currents in the shield are found by solving an electrical circuit. Space mapping combines both models to obtain the optimal passive shield fast and accurately. The presented optimization technique is compared with gradient, simplex, and genetic algorithms.

IMFIT: A FAST, FLEXIBLE NEW PROGRAM FOR ASTRONOMICAL IMAGE FITTING

DOE Office of Scientific and Technical Information (OSTI.GOV)

Erwin, Peter; Universitäts-Sternwarte München, Scheinerstrasse 1, D-81679 München

2015-02-01

I describe a new, open-source astronomical image-fitting program called IMFIT, specialized for galaxies but potentially useful for other sources, which is fast, flexible, and highly extensible. A key characteristic of the program is an object-oriented design that allows new types of image components (two-dimensional surface-brightness functions) to be easily written and added to the program. Image functions provided with IMFIT include the usual suspects for galaxy decompositions (Sérsic, exponential, Gaussian), along with Core-Sérsic and broken-exponential profiles, elliptical rings, and three components that perform line-of-sight integration through three-dimensional luminosity-density models of disks and rings seen at arbitrary inclinations. Available minimization algorithmsmore » include Levenberg-Marquardt, Nelder-Mead simplex, and Differential Evolution, allowing trade-offs between speed and decreased sensitivity to local minima in the fit landscape. Minimization can be done using the standard χ{sup 2} statistic (using either data or model values to estimate per-pixel Gaussian errors, or else user-supplied error images) or Poisson-based maximum-likelihood statistics; the latter approach is particularly appropriate for cases of Poisson data in the low-count regime. I show that fitting low-signal-to-noise ratio galaxy images using χ{sup 2} minimization and individual-pixel Gaussian uncertainties can lead to significant biases in fitted parameter values, which are avoided if a Poisson-based statistic is used; this is true even when Gaussian read noise is present.« less

Crewmembers in the spacelab.

NASA Image and Video Library

1992-07-09

STS050-255-027 (25 June-9 July 1992) --- Payload specialist Eugene H. Trinh, left, and astronaut Carl J. Meade, mission specialist, go to work in the U.S. Microgravity Laboratory (USML-1) science module as the blue shift crew takes over from the red. Trinh is working with an experiment at the Drop Physics Module (DPM) and Meade prepares to monitor an experiment in the Glovebox. The two joined four other astronauts and a second scientist from the private sector for 14-days of scientific data-gathering.

A waterborne outbreak of hepatitis A in Meade County, Kentucky.

PubMed Central

Bergeisen, G H; Hinds, M W; Skaggs, J W

1985-01-01

In November 1982, Meade County, Kentucky health officials noted a sudden increase in the incidence of hepatitis A. Using a standardized interview of 73 cases (68 serologically confirmed), and 85 controls (all negative for antibody to hepatitis A virus), the most important risk factor identified was household use of untreated water from a single spring. A dose-response relationship was found for consumption of unboiled spring water. Water samples taken from the spring during the outbreak were contaminated with fecal coliforms. PMID:3966622

Use of Excel ion exchange equilibrium solver with WinGEMS to model and predict NPE distribution in the Mead/Westvaco Evandale, TX, hardwood bleach plant

Treesearch

Christopher Litvay; Alan Rudie; Peter Hart

2003-01-01

An Excel spreadsheet developed to solve the ion-exchange equilibrium in wood pulps has been linked by dynamic data exchange to WinGEMS and used to model the non-process elements in the hardwood bleach plant of the Mead/Westvaco Evandale mill. Pulp and filtrate samples were collected from the diffusion washers and final wash press of the bleach plant. A WinGEMS model of...

Testing a Novel 3D Printed Radiographic Imaging Device for Use in Forensic Odontology.

PubMed

Newcomb, Tara L; Bruhn, Ann M; Giles, Bridget; Garcia, Hector M; Diawara, Norou

2017-01-01

There are specific challenges related to forensic dental radiology and difficulties in aligning X-ray equipment to teeth of interest. Researchers used 3D printing to create a new device, the combined holding and aiming device (CHAD), to address the positioning limitations of current dental X-ray devices. Participants (N = 24) used the CHAD, soft dental wax, and a modified external aiming device (MEAD) to determine device preference, radiographer's efficiency, and technique errors. Each participant exposed six X-rays per device for a total of 432 X-rays scored. A significant difference was found at the 0.05 level between the three devices (p = 0.0015), with the MEAD having the least amount of total errors and soft dental wax taking the least amount of time. Total errors were highest when participants used soft dental wax-both the MEAD and the CHAD performed best overall. Further research in forensic dental radiology and use of holding devices is needed. © 2016 American Academy of Forensic Sciences.

Writing women into medical history in the 1930s: Kate Campbell Hurd-Mead and "medical women" of the past and present.

PubMed

Appel, Toby A

2014-01-01

Kate Campbell Hurd-Mead (1867–1941), a leader among second-generation women physicians in America, became a pioneer historian of women in medicine in the 1930s. The coalescence of events in her personal life, the declining status of women in medicine, and the growing significance of the new and relatively open field of history of medicine all contributed to this transformation in her career. While she endeavored to become part of the community of male physicians who wrote medical history, her primary identity remained that of a “medical woman.” For Hurd-Mead, the history of women in the past not only filled a vital gap in scholarship but served practical ends that she had earlier pursued by other means—those of inspiring and advancing the careers of women physicians of the present day, promoting organizations of women physicians, and advocating for equality of opportunity in the medical profession.

Matlab based automatization of an inverse surface temperature modelling procedure for Greenland ice cores using an existing firn densification and heat diffusion model

NASA Astrophysics Data System (ADS)

Döring, Michael; Kobashi, Takuro; Kindler, Philippe; Guillevic, Myriam; Leuenberger, Markus

2016-04-01

In order to study Northern Hemisphere (NH) climate interactions and variability, getting access to high resolution surface temperature records of the Greenland ice sheet is an integral condition. For example, understanding the causes for changes in the strength of the Atlantic meridional overturning circulation (AMOC) and related effects for the NH [Broecker et al. (1985); Rahmstorf (2002)] or the origin and processes leading the so called Dansgaard-Oeschger events in glacial conditions [Johnsen et al. (1992); Dansgaard et al., 1982] demand accurate and reproducible temperature data. To reveal the surface temperature history, it is suitable to use the isotopic composition of nitrogen (δ15N) from ancient air extracted from ice cores drilled at the Greenland ice sheet. The measured δ15N record of an ice core can be used as a paleothermometer due to the nearly constant isotopic composition of nitrogen in the atmosphere at orbital timescales changes only through firn processes [Severinghaus et. al. (1998); Mariotti (1983)]. To reconstruct the surface temperature for a special drilling site the use of firn models describing gas and temperature diffusion throughout the ice sheet is necessary. For this an existing firn densification and heat diffusion model [Schwander et. al. (1997)] is used. Thereby, a theoretical δ15N record is generated for different temperature and accumulation rate scenarios and compared with measurement data in terms of mean square error (MSE), which leads finally to an optimization problem, namely the finding of a minimal MSE. The goal of the presented study is a Matlab based automatization of this inverse modelling procedure. The crucial point hereby is to find the temperature and accumulation rate input time series which minimizes the MSE. For that, we follow two approaches. The first one is a Monte Carlo type input generator which varies each point in the input time series and calculates the MSE. Then the solutions that fulfil a given limit or the best solutions for a given number of iterations are saved and used as a new input for the next model run. This procedure is repeated until the MSE undercuts a given threshold (e.g. the analytical error of the measurement data). For the second approach, different Matlab based derivative free optimization algorithms (DFOAs) (i.a. the Nelder-Mead Simplex Method, [Lagarias et al. (1998)]) are studied with an adaptation of the manual method of Kindler et al. (2013). For that the DFOAs are used to find those values for the temperature sensitivity and offset for calculating the surface temperature from the oxygen isotope records of the ice core water samples minimizing the MSE. Finally, a comparison to surface temperature records gained with different other methods for Glacial as well as Holocene data is planned. References: Broecker, W. S., Peteet, D., and Rind, D. (1985). Does the ocean-atmosphere system have more than one stable mode of operation? Nature, 315(6014):21-26. Dansgaard, W., Clausen, H., Gundestrup, N., Hammer, C., Johnsen, S., Gristinsdottir, P., and Reeh, N. (1982). A new Greenland deep ice core. Science, 218(4579):1273-1277. Johnsen, S. J., Clausen, H. B., Dansgaard, W., Fuhrer, K., Gundestrup, N., Hammer, C. U., Iversen, P., Jouzel, J., Stauffer, B., and Steffensen, J.P. (1992). Irregular glacial interstadials recorded in new Greenland ice core. Nature, 359:311- 313. Kindler, P., Guillevic, M., Baumgartner M., Schwander J., Landais A. and Leuenberger, M. (2013). NGRIP Temperature Reconstruction from 10 to 120 kyr b2k. Clim. Past, 9:4099-4143. Lagarias, J.C., Reeds, J. A., Wright, M. H., and Wright, P. E. (1998). Convergence Properties of the Nelder-Mead Simplex Method in Low Dimensions. SIAM Journal of Optimization, Vol. 9 Number 1, pp. 112-147. Mariotti, A. (1983). Atmospheric nitrogen is a reliable standard for natural 15N abundance measurements. Nature, 303:685- 687. Rahmstorf, S. (2002). Ocean circulation and climate during the past 120,000 years. Nature,419(6903):207-214. Severinghaus, J. P., Sowers, T., Brook, E. J., Alley, R. B., and Bender, M. L. (1998). Timing of abrupt climate change at the end of the Younger Dryas interval from thermally fractionated gases in polar ice. Nature, 391:141-146. Schwander, J., Sowers, T., Barnola, J., Blunier, T., Fuchs, A., and Malaizé, B. (1997). Age scale of the air in the summit ice: implication for glacial-interglacial temperature change. J. Geophys. Res-Atmos., 102(D16):19483-19493.

Simplex volume analysis for finding endmembers in hyperspectral imagery

NASA Astrophysics Data System (ADS)

Li, Hsiao-Chi; Song, Meiping; Chang, Chein-I.

2015-05-01

Using maximal simplex volume as an optimal criterion for finding endmembers is a common approach and has been widely studied in the literature. Interestingly, very little work has been reported on how simplex volume is calculated. It turns out that the issue of calculating simplex volume is much more complicated and involved than what we may think. This paper investigates this issue from two different aspects, geometric structure and eigen-analysis. The geometric structure is derived from its simplex structure whose volume can be calculated by multiplying its base with its height. On the other hand, eigen-analysis takes advantage of the Cayley-Menger determinant to calculate the simplex volume. The major issue of this approach is that when the matrix is ill-rank where determinant is desired. To deal with this problem two methods are generally considered. One is to perform data dimensionality reduction to make the matrix to be of full rank. The drawback of this method is that the original volume has been shrunk and the found volume of a dimensionality-reduced simplex is not the real original simplex volume. Another is to use singular value decomposition (SVD) to find singular values for calculating simplex volume. The dilemma of this method is its instability in numerical calculations. This paper explores all of these three methods in simplex volume calculation. Experimental results show that geometric structure-based method yields the most reliable simplex volume.

Conformational Space Annealing explained: A general optimization algorithm, with diverse applications

NASA Astrophysics Data System (ADS)

Joung, InSuk; Kim, Jong Yun; Gross, Steven P.; Joo, Keehyoung; Lee, Jooyoung

2018-02-01

Many problems in science and engineering can be formulated as optimization problems. One way to solve these problems is to develop tailored problem-specific approaches. As such development is challenging, an alternative is to develop good generally-applicable algorithms. Such algorithms are easy to apply, typically function robustly, and reduce development time. Here we provide a description for one such algorithm called Conformational Space Annealing (CSA) along with its python version, PyCSA. We previously applied it to many optimization problems including protein structure prediction and graph community detection. To demonstrate its utility, we have applied PyCSA to two continuous test functions, namely Ackley and Eggholder functions. In addition, in order to provide complete generality of PyCSA to any types of an objective function, we demonstrate the way PyCSA can be applied to a discrete objective function, namely a parameter optimization problem. Based on the benchmarking results of the three problems, the performance of CSA is shown to be better than or similar to the most popular optimization method, simulated annealing. For continuous objective functions, we found that, L-BFGS-B was the best performing local optimization method, while for a discrete objective function Nelder-Mead was the best. The current version of PyCSA can be run in parallel at the coarse grained level by calculating multiple independent local optimizations separately. The source code of PyCSA is available from http://lee.kias.re.kr.

Resource Balancing Control Allocation

NASA Technical Reports Server (NTRS)

Frost, Susan A.; Bodson, Marc

2010-01-01

Next generation aircraft with a large number of actuators will require advanced control allocation methods to compute the actuator commands needed to follow desired trajectories while respecting system constraints. Previously, algorithms were proposed to minimize the l1 or l2 norms of the tracking error and of the control effort. The paper discusses the alternative choice of using the l1 norm for minimization of the tracking error and a normalized l(infinity) norm, or sup norm, for minimization of the control effort. The algorithm computes the norm of the actuator deflections scaled by the actuator limits. Minimization of the control effort then translates into the minimization of the maximum actuator deflection as a percentage of its range of motion. The paper shows how the problem can be solved effectively by converting it into a linear program and solving it using a simplex algorithm. Properties of the algorithm are investigated through examples. In particular, the min-max criterion results in a type of resource balancing, where the resources are the control surfaces and the algorithm balances these resources to achieve the desired command. A study of the sensitivity of the algorithms to the data is presented, which shows that the normalized l(infinity) algorithm has the lowest sensitivity, although high sensitivities are observed whenever the limits of performance are reached.

High prevalence of Anisakis simplex hypersensitivity and allergy in Sicily, Italy.

PubMed

Heffler, Enrico; Sberna, Maria Eva; Sichili, Stefania; Intravaia, Rossella; Nicolosi, Giuliana; Porto, Morena; Liuzzo, Maria Teresa; Picardi, Giuseppe; Fichera, Silvia; Crimi, Nunzio

2016-02-01

Anisakis simplex can elicit allergic reactions when ingested in raw or marinated fish. The prevalence of A simplex hypersensitivity and allergy in Sicily (Italy), an area where the consumption of raw or marinated fish is very common, has not been investigated thus far. To investigate the prevalence of A simplex sensitization and its clinical relevance in a large group of unselected patients. All consecutive patients referred to the authors' allergy clinic during a 22 month-period were included in the study, evaluated for sensitization to A simplex and other allergens depending on their clinical history, and investigated for allergic symptoms after the ingestion of raw or marinated fish. Of 3,419 patients screened, 527 (15.4%) were sensitized to A simplex and 29 of these (5.5% of sensitized patients) had a history of A simplex allergy. Approximately 30% of patients had mono-sensitization to A simplex. Co-sensitization to house dust mites or molds yielded an odds ratio of 1.98 or 3.18, respectively, for allergy to A simplex. A high prevalence of A simplex sensitization in a large proportion of patients with mono-sensitization was found, confirming that eating habits influence sensitization to this nematode. Allergic symptoms from A simplex ingestion in raw or marinated fish were quite frequent, with symptoms ranging from oral allergy syndrome to anaphylaxis. Patients sensitized to A simplex were more prone to have allergic symptoms when they had co-sensitization to house dust mites or molds, suggesting possible cross-reactive but clinically relevant allergens between these allergenic sources. Copyright © 2016. Published by Elsevier Inc.

[Post-herpes simplex encephalitis chorea: Viral replication or immunological mechanism?].

PubMed

Benrhouma, H; Nasri, A; Kraoua, I; Klaa, H; Turki, I; Gouider-Khouja, N

2015-09-01

Herpes simplex encephalitis is a severe neurological condition, whose outcome is improved if treated early with acyclovir. Post-herpes simplex encephalitis with acute chorea has rarely been reported. We report on two observations of children presenting with post-herpes simplex encephalitis with acute chorea, related to two different pathophysiological mechanisms. The first one is an 11-month-old girl developing relapsing herpes simplex encephalitis with chorea due to resumption of viral replication. The second one is a 2-year-old boy with relapsing post-herpes simplex encephalitis acute chorea caused by an immunoinflammatory mechanism. We discuss the different neurological presentations of herpetic relapses, notably those presenting with movement disorders, as well as their clinical, paraclinical, physiopathological, and therapeutic aspects. Post-herpes simplex encephalitis with acute chorea may involve two mechanisms: resumption of viral replication or an immunoinflammatory mechanism. Treatment of post-herpes simplex encephalitis with acute chorea depends on the underlying mechanism, while prevention is based on antiviral treatment of herpes simplex encephalitis with acyclovir at the dose of 20mg/kg/8h for 21 days. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

[Clinical, epidemiological, and etiological studies of adult aseptic meningitis: a report of 12 cases of herpes simplex meningitis, and a comparison with cases of herpes simplex encephalitis].

PubMed

Himeno, Takahiro; Shiga, Yuji; Takeshima, Shinichi; Tachiyama, Keisuke; Kamimura, Teppei; Kono, Ryuhei; Takemaru, Makoto; Takeshita, Jun; Shimoe, Yutaka; Kuriyama, Masaru

2018-01-26

We treated 437 cases of adult aseptic meningitis and 12 cases (including 2 recurrent patients; age, 31.8 ± 8.9 years; 7 females) of herpes simplex meningitis from 2004 to 2016. The incidence rate of adult herpes simplex meningitis in the cases with aseptic meningitis was 2.7%. One patient was admitted during treatment of genital herpes, but no association was observed between genital herpes and herpes simplex meningitis in the other cases. The diagnoses were confirmed in all cases as the cerebrospinal fluid (CSF) was positive for herpes simplex virus (HSV)-DNA. For diagnosis confirmation, the DNA test was useful after 2-7 days following initial disease onset. Among other types of aseptic meningitis, the patients with herpes simplex meningitis showed relatively high white blood cell counts and relatively high CSF protein and high CSF cell counts. CSF cells showed mononuclear cell dominance from the initial stage of the disease. During same period, we also experienced 12 cases of herpes simplex encephalitis and 21 cases of non-hepatic acute limbic encephalitis. Notably, the patients with herpes simplex meningitis were younger and their CSF protein and cells counts were higher than those of the patients with herpes simplex encephalitis.

Proceedings of a Seminar on Flood Damage Reduction Reconnaissance-Phase Studies Held in Davis, California on 9-11 August 1988

DTIC Science & Technology

1988-09-01

report for the Reelfoot Lake , Tennessee, study was submitted to HQUSACF on 13 November 1986. An Issue Resolution Conference was held on 6 April 1988...and 50 miles in length (north-south direction) with 1,590 square miles of drainage area at its mouth at Lake Mead, a man-made lake created by Hoover Dam...northwest part of the drainage area and flows generally south- east for about 45 miles to Lake Mead. Numerous ephemeral and generally IChief, Hydrology

Anisakis simplex allergy: a murine model of anaphylaxis induced by parasitic proteins displays a mixed Th1/Th2 pattern

PubMed Central

Baeza, M L; Conejero, L; Higaki, Y; Martín, E; Pérez, C; Infante, S; Rubio, M; Zubeldia, J M

2005-01-01

The study of the singular hypersensitivity reactions to Anisakis simplex (A.s) proteins, may help us to undestand many of the unknown immune interactions between helmiths infections and allergy. We have developed a murine model of allergy to A. simplex, that mimics human A. simplex allergy to study the specific aspects of anaphylaxis induced by parasites. Male C3H/HeJ mice were intraperitoneally sensitized to A. simplex. Mice were then intravenous or orally challenged with A. simplex. Antigen-specific immunoglobulins, polyclonal IgE, anaphylactic symptoms, plasma histamine levels and cytokine profiles were determined. Comparative IgE immunoblot analyses were also performed. Specific IgE, IgG1 and IgG2a were detected in sensitized mice since week 3. Polyclonal IgE raised and peaked with different kinetics. Intravenous A. simplex challenge produced anaphylaxis in mice, accompanied by plasma histamine release. Oral A. simplex challenge in similarly sensitized mice did not caused symptoms nor histamine release. Numerous A. simplex allergens were recognized by sensitized mouse sera, some of them similar to human serum. The A. simplex stimulated splenocytes released IL-10, IFN-γ, IL-4, IL-13 and IL-5. We describe a new animal model of anaphylaxis. It exhibits characteristics of type I hypersensitivity reactions to Anisakis simplex similar to those observed in allergic humans. Different responses to i.v. or oral A. simplex challenges emerged, which did not reflect a window tolerization period. The cytokine profile developed (mixed Th1/Th2 pattern) differed from the observed in classical models of anaphylaxis or allergy to food antigens. This model may permit to investigate the peculiar allergic reactions to parasitic proteins. PMID:16297154

Geometry and kinematics of the eastern Lake Mead fault system in the Virgin Mountains, Nevada and Arizona

USGS Publications Warehouse

Beard, Sue; Campagna, David J.; Anderson, R. Ernest

2010-01-01

The Lake Mead fault system is a northeast-striking, 130-km-long zone of left-slip in the southeast Great Basin, active from before 16 Ma to Quaternary time. The northeast end of the Lake Mead fault system in the Virgin Mountains of southeast Nevada and northwest Arizona forms a partitioned strain field comprising kinematically linked northeast-striking left-lateral faults, north-striking normal faults, and northwest-striking right-lateral faults. Major faults bound large structural blocks whose internal strain reflects their position within a left step-over of the left-lateral faults. Two north-striking large-displacement normal faults, the Lakeside Mine segment of the South Virgin–White Hills detachment fault and the Piedmont fault, intersect the left step-over from the southwest and northeast, respectively. The left step-over in the Lake Mead fault system therefore corresponds to a right-step in the regional normal fault system.Within the left step-over, displacement transfer between the left-lateral faults and linked normal faults occurs near their junctions, where the left-lateral faults become oblique and normal fault displacement decreases away from the junction. Southward from the center of the step-over in the Virgin Mountains, down-to-the-west normal faults splay northward from left-lateral faults, whereas north and east of the center, down-to-the-east normal faults splay southward from left-lateral faults. Minimum slip is thus in the central part of the left step-over, between east-directed slip to the north and west-directed slip to the south. Attenuation faults parallel or subparallel to bedding cut Lower Paleozoic rocks and are inferred to be early structures that accommodated footwall uplift during the initial stages of extension.Fault-slip data indicate oblique extensional strain within the left step-over in the South Virgin Mountains, manifested as east-west extension; shortening is partitioned between vertical for extension-dominated structural blocks and south-directed for strike-slip faults. Strike-slip faults are oblique to the extension direction due to structural inheritance from NE-striking fabrics in Proterozoic crystalline basement rocks.We hypothesize that (1) during early phases of deformation oblique extension was partitioned to form east-west–extended domains bounded by left-lateral faults of the Lake Mead fault system, from ca. 16 to 14 Ma. (2) Beginning ca. 13 Ma, increased south-directed shortening impinged on the Virgin Mountains and forced uplift, faulting, and overturning along the north and west side of the Virgin Mountains. (3) By ca. 10 Ma, initiation of the younger Hen Spring to Hamblin Bay fault segment of the Lake Mead fault system accommodated westward tectonic escape, and the focus of south-directed shortening transferred to the western Lake Mead region. The shift from early partitioned oblique extension to south-directed shortening may have resulted from initiation of right-lateral shear of the eastern Walker Lane to the west coupled with left-lateral shear along the eastern margin of the Great Basin.

RNA interference inhibits herpes simplex virus type 1 isolated from saliva samples and mucocutaneous lesions.

PubMed

Silva, Amanda Perse da; Lopes, Juliana Freitas; Paula, Vanessa Salete de

2014-01-01

The aim of this study was to evaluate the use of RNA interference to inhibit herpes simplex virus type-1 replication in vitro. For herpes simplex virus type-1 gene silencing, three different small interfering RNAs (siRNAs) targeting the herpes simplex virus type-1 UL39 gene (sequence si-UL 39-1, si-UL 39-2, and si-UL 39-3) were used, which encode the large subunit of ribonucleotide reductase, an essential enzyme for DNA synthesis. Herpes simplex virus type-1 was isolated from saliva samples and mucocutaneous lesions from infected patients. All mucocutaneous lesions' samples were positive for herpes simplex virus type-1 by real-time PCR and by virus isolation; all herpes simplex virus type-1 from saliva samples were positive by real-time PCR and 50% were positive by virus isolation. The levels of herpes simplex virus type-1 DNA remaining after siRNA treatment were assessed by real-time PCR, whose results demonstrated that the effect of siRNAs on gene expression depends on siRNA concentration. The three siRNA sequences used were able to inhibit viral replication, assessed by real-time PCR and plaque assays and among them, the sequence si-UL 39-1 was the most effective. This sequence inhibited 99% of herpes simplex virus type-1 replication. The results demonstrate that silencing herpes simplex virus type-1 UL39 expression by siRNAs effectively inhibits herpes simplex virus type-1 replication, suggesting that siRNA based antiviral strategy may be a potential therapeutic alternative. Copyright © 2014. Published by Elsevier Editora Ltda.

Evaluating Water Supply and Water Quality Management Options for Las Vegas Valley

NASA Astrophysics Data System (ADS)

Ahmad, S.

2007-05-01

The ever increasing population in Las Vegas is generating huge demand for water supply on one hand and need for infrastructure to collect and treat the wastewater on the other hand. Current plans to address water demand include importing water from Muddy and Virgin Rivers and northern counties, desalination of seawater with trade- payoff in California, water banking in Arizona and California, and more intense water conservation efforts in the Las Vegas Valley (LVV). Water and wastewater in the LVV are intrinsically related because treated wastewater effluent is returned back to Lake Mead, the drinking water source for the Valley, to get a return credit thereby augmenting Nevada's water allocation from the Colorado River. The return of treated wastewater however, is a major contributor of nutrients and other yet unregulated pollutants to Lake Mead. Parameters that influence the quantity of water include growth of permanent and transient population (i.e., tourists), indoor and outdoor water use, wastewater generation, wastewater reuse, water conservation, and return flow credits. The water quality of Lake Mead and the Colorado River is affected by the level of treatment of wastewater, urban runoff, groundwater seepage, and a few industrial inputs. We developed an integrated simulation model, using system dynamics modeling approach, to account for both water quantity and quality in the LVV. The model captures the interrelationships among many variables that influence both, water quantity and water quality. The model provides a valuable tool for understanding past, present and future pathways of water and its constituents in the LVV. The model is calibrated and validated using the available data on water quantity (flows at water and wastewater treatment facilities and return water credit flow rates) and water quality parameters (TDS and phosphorus concentrations). We used the model to explore important questions: a)What would be the effect of the water transported from the northern counties on the water supply and water quality of Lake Mead? b)What would be the impact of increased reuse of wastewater on return credits? c)What would be the effect of treating runoff water on the load of nutrients to Lake Mead?

On Evaluating circulation and temperature stratification under changing water levels in Lake Mead with a 3D hydrodynamic model

NASA Astrophysics Data System (ADS)

Li, Y.; Acharya, K.; Chen, D.; Stone, M.; Yu, Z.; Young, M.; Zhu, J.; Shafer, D. S.; Warwick, J. J.

2009-12-01

Sustained drought in the western United States since 2000 has led to a significant drop (about 35 meters) in the water level of Lake Mead, the largest reservoir by volume in United States. The drought combined with rapid urban development in southern Nevada and emergence of invasive species has threatened the water quality and ecological processes in Lake Mead. A three-dimensional hydrodynamic model, Environmental Fluid Dynamics Code (EFDC), was applied to investigate lake circulation and temperature stratification in parts of Lake Mead (Las Vegas Bay and Boulder Basin) under changing water levels. Besides the inflow from Las Vegas Wash and the Colorado River, the model considered atmospheric changes as well as the boundary conditions restricted by the operation of Hoover Dam. The model was calibrated and verified by using observed data including water level, velocity, and temperature from 2003 and 2005. The model was applied to study the hydrodynamic processes at water level 366.8 m (year 2000) and at water level 338.2 m (year 2008). The high-stage simulation described the pre-drought lake hydrodynamic processes while the low-stage simulation highlighted the drawdown impact on such processes. The results showed that both inflow and wind-driven mixing process played major roles in the thermal stratification and lake circulation in both cases. However, the atmospheric boundary played a more important role than inflow temperature on thermal stratification of Lake Mead during water level decline. Further, the thermal stratification regime and flow circulation pattern in shallow lake regions (e.g.., the Boulder Basin area) were most impacted. The temperature of the lake at the high-stage was more sensitive to inflow temperatures than at low-stage. Furthermore, flow velocities decreased with the decreasing water level due to reduction in wind impacts, particularly in shallow areas of the lake. Such changes in temperature and lake current due to present drought have a strong influence on contaminant and nutrient dynamics and ecosystem of the lake.

KENNEDY SPACE CENTER, FLA. - The turbulent weather common to a Florida afternoon in the summer subsides into a serene canopy of cornflower blue, and a manmade "bird" takes flight. The Space Shuttle Discovery soars skyward from Launch Pad 39B on Mission STS-64 at 6:22:35 p.m. EDT, Sept. 9. On board are a crew of six: Commander Richard N. Richards; Pilot L. Blaine Hammond Jr.; and Mission Specialists Mark C. Lee, Carl J. Meade, Susan J. Helms and Dr. J.M. Linenger. Payloads for the flight include the Lidar In-Space Technology Experiment (LITE), the Shuttle Pointed Autonomous Research Tool for Astronomy-201 (SPARTAN-201) and the Robot Operated Material Processing System (ROMPS). Mission Specialists Lee and Meade also are scheduled to perform an extravehicular activity during the 64th Shuttle mission.

NASA Image and Video Library

1994-09-09

KENNEDY SPACE CENTER, FLA. - The turbulent weather common to a Florida afternoon in the summer subsides into a serene canopy of cornflower blue, and a manmade "bird" takes flight. The Space Shuttle Discovery soars skyward from Launch Pad 39B on Mission STS-64 at 6:22:35 p.m. EDT, Sept. 9. On board are a crew of six: Commander Richard N. Richards; Pilot L. Blaine Hammond Jr.; and Mission Specialists Mark C. Lee, Carl J. Meade, Susan J. Helms and Dr. J.M. Linenger. Payloads for the flight include the Lidar In-Space Technology Experiment (LITE), the Shuttle Pointed Autonomous Research Tool for Astronomy-201 (SPARTAN-201) and the Robot Operated Material Processing System (ROMPS). Mission Specialists Lee and Meade also are scheduled to perform an extravehicular activity during the 64th Shuttle mission.

Evidence against translational repression by the carboxyltransferase component of Escherichia coli acetyl coenzyme A carboxylase.

PubMed

Smith, Alexander C; Cronan, John E

2014-11-01

In Escherichia coli, synthesis of the malonyl coenzyme A (malonyl-CoA) required for membrane lipid synthesis is catalyzed by acetyl-CoA carboxylase, a large complex composed of four subunits. The subunit proteins are needed in a defined stoichiometry, and it remains unclear how such production is achieved since the proteins are encoded at three different loci. Meades and coworkers (G. Meades, Jr., B. K. Benson, A. Grove, and G. L. Waldrop, Nucleic Acids Res. 38:1217-1227, 2010, doi:http://dx.doi.org/10.1093/nar/gkp1079) reported that coordinated production of the AccA and AccD subunits is due to a translational repression mechanism exerted by the proteins themselves. The AccA and AccD subunits form the carboxyltransferase (CT) heterotetramer that catalyzes the second partial reaction of acetyl-CoA carboxylase. Meades et al. reported that CT tetramers bind the central portions of the accA and accD mRNAs and block their translation in vitro. However, long mRNA molecules (500 to 600 bases) were required for CT binding, but such long mRNA molecules devoid of ribosomes seemed unlikely to exist in vivo. This, plus problematical aspects of the data reported by Meades and coworkers, led us to perform in vivo experiments to test CT tetramer-mediated translational repression of the accA and accD mRNAs. We report that increased levels of CT tetramer have no detectable effect on translation of the CT subunit mRNAs. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

Evidence against Translational Repression by the Carboxyltransferase Component of Escherichia coli Acetyl Coenzyme A Carboxylase

PubMed Central

Smith, Alexander C.

2014-01-01

In Escherichia coli, synthesis of the malonyl coenzyme A (malonyl-CoA) required for membrane lipid synthesis is catalyzed by acetyl-CoA carboxylase, a large complex composed of four subunits. The subunit proteins are needed in a defined stoichiometry, and it remains unclear how such production is achieved since the proteins are encoded at three different loci. Meades and coworkers (G. Meades, Jr., B. K. Benson, A. Grove, and G. L. Waldrop, Nucleic Acids Res. 38:1217–1227, 2010, doi:http://dx.doi.org/10.1093/nar/gkp1079) reported that coordinated production of the AccA and AccD subunits is due to a translational repression mechanism exerted by the proteins themselves. The AccA and AccD subunits form the carboxyltransferase (CT) heterotetramer that catalyzes the second partial reaction of acetyl-CoA carboxylase. Meades et al. reported that CT tetramers bind the central portions of the accA and accD mRNAs and block their translation in vitro. However, long mRNA molecules (500 to 600 bases) were required for CT binding, but such long mRNA molecules devoid of ribosomes seemed unlikely to exist in vivo. This, plus problematical aspects of the data reported by Meades and coworkers, led us to perform in vivo experiments to test CT tetramer-mediated translational repression of the accA and accD mRNAs. We report that increased levels of CT tetramer have no detectable effect on translation of the CT subunit mRNAs. PMID:25157077

AmeriFlux US-Ne1 Mead - irrigated continuous maize site

DOE Data Explorer

Suyker, Andy [University of Nebraska - Lincoln

2016-01-01

This is the AmeriFlux version of the carbon flux data for the site US-Ne1 Mead - irrigated continuous maize site. Site Description - The study site is one of three fields (all located within 1.6 km of each other) at the University of Nebraska Agricultural Research and Development Center near Mead, Nebraska. This site is irrigated with a center pivot system. Prior to the initiation of the study, the irrigated site had a 10-yr history of maize-soybean rotation under no-till. A tillage operation (disking) was done just prior to the 2001 planting to homogenize the top 0.1 m of soil, incorporate P and K fertilizers, as well as previously accumulated surface residues. Since the tillage operation, the site has been under no-till management until the harvest of 2005. Following harvest, a conservation-plow tillage operation was initiated where a small amount of N fertilizer is sprayed on the residue immediately prior to the plow operation. Approximately 1/3 of the crop residue is left on the surface. The post-harvest conservation-plow operation continues as the current practice.

Recent vegetation changes along the Colorado River between Glen Canyon Dam and Lake Mead, Arizona

USGS Publications Warehouse

Turner, Raymond Marriner; Karpiscak, Martin M.

1980-01-01

Vegetation changes in the canyon of the Colorado River between Glen Canyon Dam and Lake Mead were studied by comparing photographs taken prior to completion of Glen Canyon Dam in 1963 with photographs taken afterwards at the same sites. In general, the older pictures show an absence of riparian plants along the banks of the river. The newer photographs of each pair were taken in 1972 through 1976 and reveal an increased density of many plant species. Exotic species, such as saltcedar and camel-thorn, and native riparian plants such as sandbar willow, arrowweed, desert broom and cattail, now form a new riparian community along much of the channel of the Colorado River between Glen Canyon Dam and Lake Mead. The matched photographs also reveal that changes have occurred in the amount of sand and silt deposited along the banks. Detailed maps are presented showing distribution of 25 plant species along the reach of the Colorado River studied. Data showing changes in the hydrologic regime since completion of Glen Canyon Dam are presented. (Kosco-USGS)

First solar radio spectrometer deployed in Scotland, UK

NASA Astrophysics Data System (ADS)

Monstein, Christian

2012-10-01

A new Callisto solar radio spectrometer system has recently been installed and set into operation at Acre Road Observatory, a facility of University of Glasgow, Scotland UK. There has been an Observatory associated with Glasgow University since 1757, and they presently occupy two different sites. The main observatory ('Acre Road') is close to the Garscube Estate on the outskirts of the city of Glasgow. The outstation ('Cochno', housing the big 20 inch Grubb Parsons telescope) is located farther out at a darker site in the Kilpatrick Hills. The Acre Road Observatory comprises teaching and research labs, a workshop, the main dome housing the 16 inch Meade, the solar dome, presently housing the 12 inch Meade, a transit house containing the transit telescope, a 3m HI radio telescope and a 408 MHz pulsar telescope. They also have 10 and 8 inch Meade telescopes and several 5 inch Celestron instruments. There is a small planetarium beneath the solar dome. The new Callisto instrument is mainly foreseen for scientific solar burst observations as well as for student projects and for 'bad-weather' outreach activities.

Global parameter estimation for thermodynamic models of transcriptional regulation.

PubMed

Suleimenov, Yerzhan; Ay, Ahmet; Samee, Md Abul Hassan; Dresch, Jacqueline M; Sinha, Saurabh; Arnosti, David N

2013-07-15

Deciphering the mechanisms involved in gene regulation holds the key to understanding the control of central biological processes, including human disease, population variation, and the evolution of morphological innovations. New experimental techniques including whole genome sequencing and transcriptome analysis have enabled comprehensive modeling approaches to study gene regulation. In many cases, it is useful to be able to assign biological significance to the inferred model parameters, but such interpretation should take into account features that affect these parameters, including model construction and sensitivity, the type of fitness calculation, and the effectiveness of parameter estimation. This last point is often neglected, as estimation methods are often selected for historical reasons or for computational ease. Here, we compare the performance of two parameter estimation techniques broadly representative of local and global approaches, namely, a quasi-Newton/Nelder-Mead simplex (QN/NMS) method and a covariance matrix adaptation-evolutionary strategy (CMA-ES) method. The estimation methods were applied to a set of thermodynamic models of gene transcription applied to regulatory elements active in the Drosophila embryo. Measuring overall fit, the global CMA-ES method performed significantly better than the local QN/NMS method on high quality data sets, but this difference was negligible on lower quality data sets with increased noise or on data sets simplified by stringent thresholding. Our results suggest that the choice of parameter estimation technique for evaluation of gene expression models depends both on quality of data, the nature of the models [again, remains to be established] and the aims of the modeling effort. Copyright © 2013 Elsevier Inc. All rights reserved.

Hybridisations of Variable Neighbourhood Search and Modified Simplex Elements to Harmony Search and Shuffled Frog Leaping Algorithms for Process Optimisations

NASA Astrophysics Data System (ADS)

Aungkulanon, P.; Luangpaiboon, P.

2010-10-01

Nowadays, the engineering problem systems are large and complicated. An effective finite sequence of instructions for solving these problems can be categorised into optimisation and meta-heuristic algorithms. Though the best decision variable levels from some sets of available alternatives cannot be done, meta-heuristics is an alternative for experience-based techniques that rapidly help in problem solving, learning and discovery in the hope of obtaining a more efficient or more robust procedure. All meta-heuristics provide auxiliary procedures in terms of their own tooled box functions. It has been shown that the effectiveness of all meta-heuristics depends almost exclusively on these auxiliary functions. In fact, the auxiliary procedure from one can be implemented into other meta-heuristics. Well-known meta-heuristics of harmony search (HSA) and shuffled frog-leaping algorithms (SFLA) are compared with their hybridisations. HSA is used to produce a near optimal solution under a consideration of the perfect state of harmony of the improvisation process of musicians. A meta-heuristic of the SFLA, based on a population, is a cooperative search metaphor inspired by natural memetics. It includes elements of local search and global information exchange. This study presents solution procedures via constrained and unconstrained problems with different natures of single and multi peak surfaces including a curved ridge surface. Both meta-heuristics are modified via variable neighbourhood search method (VNSM) philosophy including a modified simplex method (MSM). The basic idea is the change of neighbourhoods during searching for a better solution. The hybridisations proceed by a descent method to a local minimum exploring then, systematically or at random, increasingly distant neighbourhoods of this local solution. The results show that the variant of HSA with VNSM and MSM seems to be better in terms of the mean and variance of design points and yields.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blaut, Arkadiusz; Babak, Stanislav; Krolak, Andrzej

We present data analysis methods used in the detection and estimation of parameters of gravitational-wave signals from the white dwarf binaries in the mock LISA data challenge. Our main focus is on the analysis of challenge 3.1, where the gravitational-wave signals from more than 6x10{sup 7} Galactic binaries were added to the simulated Gaussian instrumental noise. The majority of the signals at low frequencies are not resolved individually. The confusion between the signals is strongly reduced at frequencies above 5 mHz. Our basic data analysis procedure is the maximum likelihood detection method. We filter the data through the template bankmore » at the first step of the search, then we refine parameters using the Nelder-Mead algorithm, we remove the strongest signal found and we repeat the procedure. We detect reliably and estimate parameters accurately of more than ten thousand signals from white dwarf binaries.« less

STS-64 Extravehicular activity (EVA) training view in WETF

NASA Image and Video Library

1994-08-10

S94-39775 (August 1994) --- Astronaut Carl J. Meade, STS-64 mission specialist, listens to ground monitors during a simulation of a spacewalk scheduled for his September mission. Meade, who shared the rehearsal in the Johnson Space Center's (JSC) Weightless Environment Training Facility (WET-F) pool with crewmate astronaut Mark C. Lee, is equipped with a training version of new extravehicular activity (EVA) hardware called the Simplified Aid for EVA Rescue (SAFER) system. The hardware includes a mobility-aiding back harness and a chest-mounted hand control module. Photo credit: NASA or National Aeronautics and Space Administration

STS-64 Extravehicular activity (EVA) training view in WETF

NASA Image and Video Library

1994-08-10

S94-39762 (August 1994) --- Astronaut Carl J. Meade, STS-64 mission specialist, listens to ground monitors prior to a simulation of a spacewalk scheduled for his September mission. Meade, who shared the rehearsal in Johnson Space Center's (JSC) Weightless Environment Training Facility (WET-F) pool with crewmate astronaut Mark C. Lee (out of frame), is equipped with a training version of new extravehicular activity (EVA) hardware called the Simplified Aid for EVA Rescue (SAFER) system. The hardware includes a mobility-aiding back harness and a chest-mounted hand control module. Photo credit: NASA or National Aeronautics and Space Administration

Prefixation of Simplex Pairs in Czech: An Analysis of Spatial Semantics, Distributive Verbs, and Procedural Meanings

ERIC Educational Resources Information Center

Hilchey, Christian Thomas

2014-01-01

This dissertation examines prefixation of simplex pairs. A simplex pair consists of an iterative imperfective and a semelfactive perfective verb. When prefixed, both of these verbs are perfective. The prefixed forms derived from semelfactives are labeled single act verbs, while the prefixed forms derived from iterative imperfective simplex verbs…

Transient neuropathic bladder following herpes simplex genitalis.

PubMed

Riehle, R A; Williams, J J

1979-08-01

A case of transient bladder dysfunction and urinary retention concomitant with herpes genitalis is presented. The protean manifestations of the herpes simplex virus, the similar neurotropic behavior of simplex and zoster, and the neurologic sequelae of the cutaneous simplex eruption are discussed. The possibility of sacral radiculopathy after herpes genitalis must be considered when evaluating acute or episodic neurogenic bladders.

Herpes simplex virus following stab phlebectomy.

PubMed

Hicks, Caitlin W; Lum, Ying Wei; Heller, Jennifer A

2017-03-01

Herpes simplex virus infection following surgery is an unusual postoperative phenomenon. Many mechanisms have been suggested, with the most likely explanation related to latent virus reactivation due to a proinflammatory response in the setting of local trauma. Here, we present a case of herpes simplex virus reactivation in an immunocompetent female following a conventional right lower extremity stab phlebectomy. Salient clinical and physical examination findings are described, and management strategies for herpes simplex virus reactivation are outlined. This is the first known case report of herpes simplex virus reactivation following lower extremity phlebectomy.

Inactivation of Herpes Simplex Viruses by Nonionic Surfactants

PubMed Central

Asculai, Samuel S.; Weis, Margaret T.; Rancourt, Martha W.; Kupferberg, A. B.

1978-01-01

Nonionic surface-active agents possessing ether or amide linkages between the hydrophillic and hydrophobic portions of the molecule rapidly inactivated the infectivity of herpes simplex viruses. The activity stemmed from the ability of nonionic surfactants to dissolve lipid-containing membranes. This was confirmed by observing surfactant destruction of mammalian cell plasma membranes and herpes simplex virus envelopes. Proprietary vaginal contraceptive formulations containing nonionic surfactants also inactivated herpes simplex virus infectivity. This observation suggests that nonionic surfactants in appropriate formulation could effectively prevent herpes simplex virus transmission. Images PMID:208460

An efficient algorithm for generating diverse microstructure sets and delineating properties closures

DOE PAGES

Johnson, Oliver K.; Kurniawan, Christian

2018-02-03

Properties closures delineate the theoretical objective space for materials design problems, allowing designers to make informed trade-offs between competing constraints and target properties. In this paper, we present a new algorithm called hierarchical simplex sampling (HSS) that approximates properties closures more efficiently and faithfully than traditional optimization based approaches. By construction, HSS generates samples of microstructure statistics that span the corresponding microstructure hull. As a result, we also find that HSS can be coupled with synthetic polycrystal generation software to generate diverse sets of microstructures for subsequent mesoscale simulations. Finally, by more broadly sampling the space of possible microstructures, itmore » is anticipated that such diverse microstructure sets will expand our understanding of the influence of microstructure on macroscale effective properties and inform the construction of higher-fidelity mesoscale structure-property models.« less

An efficient algorithm for generating diverse microstructure sets and delineating properties closures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johnson, Oliver K.; Kurniawan, Christian

Properties closures delineate the theoretical objective space for materials design problems, allowing designers to make informed trade-offs between competing constraints and target properties. In this paper, we present a new algorithm called hierarchical simplex sampling (HSS) that approximates properties closures more efficiently and faithfully than traditional optimization based approaches. By construction, HSS generates samples of microstructure statistics that span the corresponding microstructure hull. As a result, we also find that HSS can be coupled with synthetic polycrystal generation software to generate diverse sets of microstructures for subsequent mesoscale simulations. Finally, by more broadly sampling the space of possible microstructures, itmore » is anticipated that such diverse microstructure sets will expand our understanding of the influence of microstructure on macroscale effective properties and inform the construction of higher-fidelity mesoscale structure-property models.« less

DD3MAT - a code for yield criteria anisotropy parameters identification.

NASA Astrophysics Data System (ADS)

Barros, P. D.; Carvalho, P. D.; Alves, J. L.; Oliveira, M. C.; Menezes, L. F.

2016-08-01

This work presents the main strategies and algorithms adopted in the DD3MAT inhouse code, specifically developed for identifying the anisotropy parameters. The algorithm adopted is based on the minimization of an error function, using a downhill simplex method. The set of experimental values can consider yield stresses and r -values obtained from in-plane tension, for different angles with the rolling direction (RD), yield stress and r -value obtained for biaxial stress state, and yield stresses from shear tests performed also for different angles to RD. All these values can be defined for a specific value of plastic work. Moreover, it can also include the yield stresses obtained from in-plane compression tests. The anisotropy parameters are identified for an AA2090-T3 aluminium alloy, highlighting the importance of the user intervention to improve the numerical fit.

Geohydrology of the Unconsolidated Valley-Fill Aquifer in the Meads Creek Valley, Schuyler and Steuben Counties, New York

USGS Publications Warehouse

Miller, Todd S.; Bugliosi, Edward F.; Reddy, James E.

2008-01-01

The Meads Creek valley encompasses 70 square miles of predominantly forested uplands in the upper Susquehanna River drainage basin. The valley, which was listed as a Priority Waterbody by the New York State Department of Environmental Conservation in 2004, is prone to periodic flooding, mostly in its downstream end, where development is occurring most rapidly. Hydraulic characteristics of the unconsolidated valley-fill aquifer were evaluated, and seepage rates in losing and gaining tributaries were calculated or estimated, in an effort to delineate the aquifer geometry and identify the factors that contribute to flooding. Results indicated that (1) Meads Creek gained about 61 cubic feet of flow per second (about 6.0 cubic feet per second per mile of stream channel) from ground-water discharge and inflow from tributaries in its 10.2-mile reach between the northernmost and southernmost measurement sites; (2) major tributaries in the northern part of the valley are not significant sources of recharge to the aquifer; and (3) major tributaries in the central and southern part of the valley provide recharge to the aquifer. The ground-water portion of streamflow in Meads Creek (excluding tributary inflow) was 11.3 cubic feet per second (ft3/s) in the central part of the valley and 17.2 ft3/s in the southern part - a total of 28.5 ft3/s. Ground-water levels were measured in 29 wells finished in unconfined deposits for construction of a potentiometric-surface map to depict directions of ground-water flow within the valley. In general, ground water flows from the edges of the valley toward Meads Creek and ultimately discharges to it. The horizontal hydraulic gradient for the entire 12-mile-long aquifer averages about 30 feet per mile, whereas the gradient in the southern fourth of the valley averages about half that - about 17 feet per mile. A water budget for the aquifer indicated that 28 percent of recharge was derived from precipitation that falls on the aquifer, 32 percent was from losing reaches of tributaries, 38 percent was unchanneled flow from hillsides that slope toward the valley (this estimate includes runoff and shallow ground-water inflow from till and bedrock), and the remaining 2 percent was from deep ground-water inflow from till and bedrock to the sides and bottom of the aquifer. Nearly all (94 percent) of the water discharged from the aquifer is equivalent to the streamflow gain in Meads Creek; the remaining 6 percent discharges as deep outflow to unconsolidated deposits in the Cohocton River valley. Several characteristics of the Meads Creek valley may contribute to flooding in the downstream area: (1) the southward decrease in the ground-water gradient impedes the ability of the aquifer to transmit water southward and can cause water levels to rise, (2) a high water table, typically only 5 to 10 feet below land surface, results in little storage capacity to absorb water from large storms, (3) a downstream narrowing of the valley impedes the southward flow of ground water and can cause water levels to rapidly rise during periods of prolonged or heavy precipitation, and (4) the upland slopes (till-covered bedrock) produce rapid runoff that recharges the aquifer. The combined effect of these conditions limits the ability of the aquifer to transmit sudden, large increases in recharge from precipitation and thereby provides a high potential for flooding in the southern third of the valley.

First Fourteen Years of Lake Mead

USGS Publications Warehouse

Thomas, Harold E.

1954-01-01

This circular summarizes the results of recent studies of Lake Mead and its environs. Area-capacity tables, prepared on the basis of a hydrographic survey of the lake in 1948-49, show that the capacity of the reservoir was reduced 4.9 percent during the first 14 years after Hoover Dam was completed, but the usable capacity was reduced only 3.2 percent. Practically all of this reduction was caused by accumulation of sediment in the reservoir. Studies of inflow and outflow indicate that the reservoir has a total storage capacity about 12 percent greater than that shown by the area-capacity table, because of 'bank' storage, or ground-water storage in the bottom and sides of the reservoir. Thus the total capacity in 1949 was greater than the quantity shown by the original area-capacity table, even though large quantities of sediment had been deposited in the reservoir during the 14 years. According to computations of the volume and weight of the accumulated sediment, about 2,000 million tons were deposited in the reservoir by the Colorado River in 14 years; this is within 2 percent of the amount calculated from measurements of the suspended sediment carried by the in flowing rivers. It is estimated that the sediment capacity of the reservoir, when filled to the level of the permanent spillway crest, is about 75,000 million tons. The sediment contributed by the Colorado River averages about 45 percent sand and 55 percent silt and clay. If the sediment carried by the river in the years 1926-50 represents the long-term average rate of accumulation in Lake Mead, it will be a century before the sediment at the dam reaches the level of the lowest gates in the intake towers, and more than 4 centuries before the reservoir is filled with sediment to the level of the permanent spillway crest. The rate of sedimentation since the first year of Lake Mead (1935) has been about 20 percent lower, and if that rate continues in the future, the life of the reservoir will be correspondingly greater. Construction of upstream reservoirs to capture some of the inflowing sediment, or transportation of sediment in the outflow through Hoover Dam, would also increase the life of the reservoir. In the first 12 years of Lake Mead, the dissolved mineral matter in the outflowing water was significantly greater than the average in the in flowing water, owing in part to solution of gypsum and rock salt from the bed of the reservoir. Currently the increased dissolved solids in the outflowing water can be accounted for almost entirely by evaporation from the reservoir, which is about 5 fo 7 percent of the annual inflow. The water from Lake Mead is habitually of better quality than that diverted from the river for irrigation prior to regulation by Hoover Dam, because it represents an average of the poor water of low stages and the excellent water from melting snow. Geodetic surveys of the Lake Mead area show that the weight of water has caused subsidence of the earth's crust amounting to about 120 millimeter at Hoover Dam, and an even greater amount in the principal area of storage in the reservoir.

Temporal and basin-specific population trends of quagga mussels on soft sediment of a multi-basin reservoir

USGS Publications Warehouse

Caldwell, Timothy J; Rosen, Michael R.; Chandra, Sudeep; Acharya, Kumud; Caires, Andrea M; Davis, Clinton J.; Thaw, Melissa; Webster, Daniel M.

2015-01-01

Invasive quagga (Dreissena bugnesis) and zebra (Dreissena ploymorpha) mussels have rapidly spread throughout North America. Understanding the relationships between environmental variables and quagga mussels during the early stages of invasion will help management strategies and allow researchers to predict patterns of future invasions. Quagga mussels were detected in Lake Mead, NV/AZ in 2007, we monitored early invasion dynamics in 3 basins (Boulder Basin, Las Vegas Bay, Overton Arm) bi-annually from 2008-2011. Mean quagga density increased over time during the first year of monitoring and stabilized for the subsequent two years at the whole-lake scale (8 to 132 individuals·m-2, geometric mean), in Boulder Basin (73 to 875 individuals·m-2), and in Overton Arm(2 to 126 individuals·m-2). In Las Vegas Bay, quagga mussel density was low (9 to 44 individuals·m-2), which was correlated with high sediment metal concentrations and warmer (> 30°C) water temperatures associated with that basin. Carbon content in the sediment increased with depth in Lake Mead and during some sampling periods quagga density was also positively correlated with depth, but more research is required to determine the significance of this interaction. Laboratory growth experiments suggested that food quantity may limit quagga growth in Boulder Basin, indicating an opportunity for population expansion in this basin if primary productivity were to increase, but was not the case in Overton Arm. Overall quagga mussel density in Lake Mead is highly variable and patchy, suggesting that temperature, sediment size, and sediment metal concentrations, and sediment carbon content all contribute to mussel distribution patterns. Quagga mussel density in the soft sediment of Lake Mead expanded during initial colonization, and began to stabilize approximately 3 years after the initial invasion.

Water-quality characteristics of stormwater runoff in Rapid City, South Dakota, 2008-14

USGS Publications Warehouse

Hoogestraat, Galen K.

2015-01-01

For the Arrowhead and Meade-Hawthorne sites, event-mean concentrations typically exceeded the TSS and bacteria beneficial-use criteria for Rapid Creek by 1–2 orders of magnitude. Comparing the two drainage basins, median TSS event-mean concentrations were more than two times greater at the Meade-Hawthorne outlet (520 milligrams per liter) than the Arrowhead outlet (200 milligrams per liter). Median fecal coliform bacteria event-mean concentrations also were greater at the Meade-Hawthorne outlet site (30,000 colony forming units per 100 milliliters) than the Arrowhead outlet site (17,000 colony forming units per 100 milliliters). A comparison to relevant standards indicates that stormwater runoff from the Downtown drainage basin exceeded criteria for bacteria and TSS, but concentrations generally were below standards for nutrients and metals. Stormwater-quality conditions from the Downtown drainage basin outfalls were similar to or better than stormwater-quality conditions observed in the Arrowhead and Meade-Hawthorne drainage basins. Three wetland channels located at the outlet of the Downtown drainage basin were evaluated for their pollutant reduction capability. Mean reductions in TSS and lead concentrations were greater than 40 percent for all three wetland channels. Total nitrogen, phosphorus, copper, and zinc concentrations also were reduced by at least 20 percent at all three wetlands. Fecal coliform bacteria concentrations typically were reduced by about 21 and 36 percent at the 1st and 2nd Street wetlands, respectively, but the reduction at the 3rd Street wetland channel was nearly zero percent. Total wetland storage volume affected pollutant reductions because TSS, phosphorus, and ammonia reductions were greatest in the wetland with the greatest volume. Chloride concentrations typically increased from inflow to outflow at the 2nd and 3rd Street wetland channels.

Unusual Clinical Presentation and Role of Decompressive Craniectomy in Herpes Simplex Encephalitis.

PubMed

Singhi, Pratibha; Saini, Arushi Gahlot; Sahu, Jitendra Kumar; Kumar, Nuthan; Vyas, Sameer; Vasishta, Rakesh Kumar; Aggarwal, Ashish

2015-08-01

Decompressive craniectomy in pediatric central nervous infections with refractory intracranial hypertension is less commonly practiced. We describe improved outcome of decompressive craniectomy in a 7-year-old boy with severe herpes simplex encephalitis and medically refractory intracranial hypertension, along with a brief review of the literature. Timely recognition of refractory intracranial hypertension and surgical decompression in children with herpes simplex encephalitis can be life-saving. Additionally, strokelike atypical presentations are being increasingly recognized in children with herpes simplex encephalitis and should not take one away from the underlying herpes simplex encephalitis. © The Author(s) 2014.

Genetics Home Reference: epidermolysis bullosa simplex

MedlinePlus

... of epidermolysis bullosa simplex . Mutations in another gene, PLEC , have been associated with the rare Ogna type of epidermolysis bullosa simplex . The PLEC gene provides instructions for making a protein called ...

The "Knife-Cut Sign" Revisited: A Distinctive Presentation of Linear Erosive Herpes Simplex Virus Infection in Immunocompromised Patients.

PubMed

Cohen, Philip R

2015-10-01

The "knife-cut sign" is a distinctive presentation of linear erosive herpes simplex virus infection in immunocompromised patients. To describe a man whose herpes simplex virus infection-related skin lesions demonstrated the "knife-cut sign" and to review the characteristics of reported immunosuppressed individuals with "knife-cut" cutaneous herpes simplex virus lesions. A man with multiple myeloma and post-stem cell transplant cutaneous graft-versus-host disease managed with systemic prednisone and sirolimus developed disseminated cutaneous herpes simplex virus infection with virus-associated linear ulcers of the inguinal folds and the area between his ear and scalp; the lesions at both sites had a distinctive "knife-cut" appearance. Using the PubMed database, an extensive literature search was performed on herpes simplex virus, immunocompromised patient, and "knife-cut sign". Herpes simplex virus infection-associated skin lesions that demonstrate the "knife-cut sign" present in patients who are immunosuppressed secondary to either an underlying medical condition or a systemic therapy or both. The distinctive virus-related cutaneous lesions appear as linear ulcers and fissures in intertriginous areas, such as the folds in the inguinal area, the vulva, and the abdomen; in addition, other sites include beneath the breast, within the gluteal cleft, and the area between the ear and the scalp. Not only herpes simplex virus-2, but also herpes simplex virus-1 has been observed as the causative viral serotype; indeed, herpes simplex virus-1 has been associated with genital and inframammary lesions in addition to those above the neck. Direct fluorescent antibody testing is a rapid method for confirming the clinically suspected viral infection; however, since false-negative direct fluorescent antibody testing occurred in some of the patients, it may be prudent to also perform viral cultures and possibly lesional skin biopsies to establish the diagnosis. The herpes simplex virus infection-related skin lesions clinically improve once systemic antiviral therapy is initiated. In immunosuppressed individuals, the "knife-cut sign" is a distinctive presentation of cutaneous linear erosive herpes simplex virus infection. Recognition of the linear ulcers in intertriginous areas and body folds should prompt the clinician to consider herpes simplex virus infection-associated skin lesions in an immunocompromised patient and to initiate systemic antiviral treatment while awaiting the results of laboratory evaluation to confirm the suspected diagnosis.

Concomitant herpes simplex virus colitis and hepatitis in a man with ulcerative colitis: Case report and review of the literature.

PubMed

Phadke, Varun K; Friedman-Moraco, Rachel J; Quigley, Brian C; Farris, Alton B; Norvell, J P

2016-10-01

Herpesvirus infections often complicate the clinical course of patients with inflammatory bowel disease; however, invasive disease due to herpes simplex virus is distinctly uncommon. We present a case of herpes simplex virus colitis and hepatitis, review all the previously published cases of herpes simplex virus colitis, and discuss common clinical features and outcomes. We also discuss the epidemiology, clinical manifestations, diagnosis, and management of herpes simplex virus infections, focusing specifically on patients with inflammatory bowel disease. A 43-year-old man with ulcerative colitis, previously controlled with an oral 5-aminosalicylic agent, developed symptoms of a colitis flare that did not respond to treatment with systemic corticosteroid therapy. One week later he developed orolabial ulcers and progressive hepatic dysfunction, with markedly elevated transaminases and coagulopathy. He underwent emergent total colectomy when imaging suggested bowel micro-perforation. Pathology from both the colon and liver was consistent with herpes simplex virus infection, and a viral culture of his orolabial lesions and a serum polymerase chain reaction assay also identified herpes simplex virus. He was treated with systemic antiviral therapy and made a complete recovery. Disseminated herpes simplex virus infection with concomitant involvement of the colon and liver has been reported only 3 times in the published literature, and to our knowledge this is the first such case in a patient with inflammatory bowel disease. The risk of invasive herpes simplex virus infections increases with some, but not all immunomodulatory therapies. Optimal management of herpes simplex virus in patients with inflammatory bowel disease includes targeted prophylactic therapy for patients with evidence of latent infection, and timely initiation of antiviral therapy for those patients suspected to have invasive disease.

Concomitant herpes simplex virus colitis and hepatitis in a man with ulcerative colitis

PubMed Central

Phadke, Varun K.; Friedman-Moraco, Rachel J.; Quigley, Brian C.; Farris, Alton B.; Norvell, J. P.

2016-01-01

Abstract Background: Herpesvirus infections often complicate the clinical course of patients with inflammatory bowel disease; however, invasive disease due to herpes simplex virus is distinctly uncommon. Methods: We present a case of herpes simplex virus colitis and hepatitis, review all the previously published cases of herpes simplex virus colitis, and discuss common clinical features and outcomes. We also discuss the epidemiology, clinical manifestations, diagnosis, and management of herpes simplex virus infections, focusing specifically on patients with inflammatory bowel disease. Results: A 43-year-old man with ulcerative colitis, previously controlled with an oral 5-aminosalicylic agent, developed symptoms of a colitis flare that did not respond to treatment with systemic corticosteroid therapy. One week later he developed orolabial ulcers and progressive hepatic dysfunction, with markedly elevated transaminases and coagulopathy. He underwent emergent total colectomy when imaging suggested bowel micro-perforation. Pathology from both the colon and liver was consistent with herpes simplex virus infection, and a viral culture of his orolabial lesions and a serum polymerase chain reaction assay also identified herpes simplex virus. He was treated with systemic antiviral therapy and made a complete recovery. Conclusions: Disseminated herpes simplex virus infection with concomitant involvement of the colon and liver has been reported only 3 times in the published literature, and to our knowledge this is the first such case in a patient with inflammatory bowel disease. The risk of invasive herpes simplex virus infections increases with some, but not all immunomodulatory therapies. Optimal management of herpes simplex virus in patients with inflammatory bowel disease includes targeted prophylactic therapy for patients with evidence of latent infection, and timely initiation of antiviral therapy for those patients suspected to have invasive disease. PMID:27759636

Granulomatous herpes simplex encephalitis in an infant with multicystic encephalopathy: a distinct clinicopathologic entity?

PubMed

Schutz, Peter W; Fauth, Clarissa T; Al-Rawahi, Ghada N; Pugash, Denise; White, Valerie A; Stockler, Sylvia; Dunham, Christopher P

2014-04-01

Herpes simplex virus encephalitis can manifest as a range of clinical presentations including classic adult, neonatal, and biphasic chronic-granulomatous herpes encephalitis. We report an infant with granulomatous herpes simplex virus type 2 encephalitis with a subacute course and multicystic encephalopathy. A 2-month-old girl presented with lethargy and hypothermia. Computed tomography scan of the head showed multicystic encephalopathy and calcifications. Cerebrospinal fluid analysis by polymerase chain reaction testing for herpes simplex virus 1 and 2, enterovirus, and cytomegalovirus was negative. Normal cerebrospinal fluid interferon-α levels argued against Aicardi-Goutières syndrome. The patient died 2 weeks after presentation. At autopsy, multicystic encephalopathy was confirmed with bilateral gliosis, granulomatous inflammation with multinucleated giant cells, and calcifications. Bilateral healing necrotizing retinitis suggested a viral etiology, but retina and brain were free of viral inclusions and immunohistochemically negative for herpes simplex virus-2 and cytomegalovirus. However, polymerase chain reaction analysis showed herpes simplex virus-2 DNA in four cerebral paraffin blocks. Subsequent repeat testing of the initial cerebrospinal fluid sample using a different polymerase chain reaction assay was weakly positive for herpes simplex virus-2 DNA. Granulomatous herpes simplex virus encephalitis in infants can present with subacute course and result in multicystic encephalopathy with mineralization and minimal cerebrospinal fluid herpes simplex virus DNA load. Infectious etiologies should be carefully investigated in the differential diagnosis of multicystic encephalopathy with mineralization, in particular if multinucleated giant cells are present. Copyright © 2014 Elsevier Inc. All rights reserved.

A Fusogenic Oncolytic Herpes Simplex Virus for Therapy of Advanced Ovarian Cancer

DTIC Science & Technology

2006-06-01

killer and NKT cells play a critical role in innate protection against genital herpes simplex virus type 2 infection. J Virol 2003;77:10168-71. 8...AD_________________ Award Number: DAMD17-03-1-0434 TITLE: A Fusogenic Oncolytic Herpes Simplex...CONTRACT NUMBER A Fusogenic Oncolytic Herpes Simplex Virus for Therapy of Advanced Ovarian Cancer 5b. GRANT NUMBER DAMD17-03-1-0434 5c

Geologic map of the Mead quadrangle (V-21), Venus

USGS Publications Warehouse

Campbell, Bruce A.; Clark, David A.

2006-01-01

The Magellan spacecraft orbited Venus from August 10, 1990, until it plunged into the Venusian atmosphere on October 12, 1994. Magellan Mission objectives included (1) improving the knowledge of the geological processes, surface properties, and geologic history of Venus by analysis of surface radar characteristics, topography, and morphology and (2) improving the knowledge of the geophysics of Venus by analysis of Venusian gravity. The Mead quadrangle (V-21) of Venus is bounded by lat 0 deg and 25 deg N., long 30 deg and 60 deg E. This quadrangle is one of 62 covering Venus at 1:5,000,000 scale. Named for the largest crater on Venus, the quadrangle is dominated by effusive volcanic deposits associated with five major coronae in eastern Eistla Regio (Didilia, Pavlova, Calakomana, Isong, and Ninmah), corona-like tectonic features, and Disani Corona. The southern extremity of Bell Regio, marked by lava flows from Nyx Mons, north of the map area, forms the north-central part of the quadrangle. The shield volcanoes Kali, Dzalarhons, and Ptesanwi Montes lie south and southwest of the large corona-related flow field. Lava flows from sources east of Mead crater flood low-lying areas along the east edge of the quadrangle.

Rapid optimization of tension distribution for cable-driven parallel manipulators with redundant cables

NASA Astrophysics Data System (ADS)

Ouyang, Bo; Shang, Weiwei

2016-03-01

The solution of tension distributions is infinite for cable-driven parallel manipulators(CDPMs) with redundant cables. A rapid optimization method for determining the optimal tension distribution is presented. The new optimization method is primarily based on the geometry properties of a polyhedron and convex analysis. The computational efficiency of the optimization method is improved by the designed projection algorithm, and a fast algorithm is proposed to determine which two of the lines are intersected at the optimal point. Moreover, a method for avoiding the operating point on the lower tension limit is developed. Simulation experiments are implemented on a six degree-of-freedom(6-DOF) CDPM with eight cables, and the results indicate that the new method is one order of magnitude faster than the standard simplex method. The optimal distribution of tension distribution is thus rapidly established on real-time by the proposed method.

Expression of varicella-zoster virus and herpes simplex virus in normal human trigeminal ganglia

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vafai, A.; Wellish, M.; Devlin, M.

1988-04-01

Lysates of radiolabeled explants from four human trigeminal ganglia were immunoprecipitated with antibodies to varicella-zoster virus (VZV) and to herpes simplex virus. Both herpes simplex virus- and VZV-specific proteins were detected in lysates of all four ganglia. Absence of reactivity in ganglion explants with monoclonal antibodies suggested that herpes simplex virus and VZV were not reactivated during the culture period. In situ hybridization studies demonstrated the presence of RNA transcripts from the VZV immediate early gene 63. This approach to the detection of herpes simplex virus and VZV expression in human ganglia should facilitate analysis of viral RNA and proteinsmore » in human sensory ganglia.« less

Agent-based station for on-line diagnostics by self-adaptive laser Doppler vibrometry

NASA Astrophysics Data System (ADS)

Serafini, S.; Paone, N.; Castellini, P.

2013-12-01

A self-adaptive diagnostic system based on laser vibrometry is proposed for quality control of mechanical defects by vibration testing; it is developed for appliances at the end of an assembly line, but its characteristics are generally suited for testing most types of electromechanical products. It consists of a laser Doppler vibrometer, equipped with scanning mirrors and a camera, which implements self-adaptive bahaviour for optimizing the measurement. The system is conceived as a Quality Control Agent (QCA) and it is part of a Multi Agent System that supervises all the production line. The QCA behaviour is defined so to minimize measurement uncertainty during the on-line tests and to compensate target mis-positioning under guidance of a vision system. Best measurement conditions are reached by maximizing the amplitude of the optical Doppler beat signal (signal quality) and consequently minimize uncertainty. In this paper, the optimization strategy for measurement enhancement achieved by the down-hill algorithm (Nelder-Mead algorithm) and its effect on signal quality improvement is discussed. Tests on a washing machine in controlled operating conditions allow to evaluate the efficacy of the method; significant reduction of noise on vibration velocity spectra is observed. Results from on-line tests are presented, which demonstrate the potential of the system for industrial quality control.

A double-blind, placebo-controlled oral challenge study with lyophilized larvae and antigen of the fish parasite, Anisakis simplex.

PubMed

Sastre, J; Lluch-Bernal, M; Quirce, S; Arrieta, I; Lahoz, C; Del Amo, A; Fernández-Caldas, E; Marañón, F

2000-06-01

The third-stage larvae of Anisakis simplex may be a hidden source of allergens in fish. The objective was to determine whether the ingestion of lyophilized A. simplex larvae, or antigen, induces clinical symptoms in a group of A. simplex-sensitized patients. Double-blind, placebo-controlled oral challenges were conducted in 11 individuals who had experienced allergic reactions after eating fish. Another patient had chronic urticaria unrelated to the ingestion of fish. All patients had positive skin tests and specific IgE determinations for A. simplex and negative skin tests to a battery of fish species. Conjunctival tests with A. simplex extracts were conducted in all patients and in five controls. The 12 patients received capsules containing either lactose or one, five, or 25 lyophilized larvae of A. simplex at 2-h intervals in a double-blind fashion. The highest single dose was 100 larvae. ECP and tryptase levels in serum were measured before and after the last oral challenge. Lyophilized antigen was also given to five patients. None of the 12 patients experienced a positive reaction after the ingestion of the placebo, the lyophilized larvae, or the antigen. Tryptase and ECP levels before and after challenges did not change significantly. Conjunctival provocation tests were positive in 11 out of the 12 patients and in none of the controls. The ingestion of 100 lyophilized A. simplex larvae, or its equivalent in antigen, does not induce clinical symptoms in individuals with a clinical history and laboratory findings of hypersensitivity to A. simplex. The data suggest that only the ingestion of live larvae may be capable of inducing allergic manifestations.

[George Herbert Mead. Thought as the conversation of interior gestures].

PubMed

Quéré, Louis

2010-01-01

For George Herbert Mead, thinking amounts to holding an "inner conversation of gestures ". Such a conception does not seem especially original at first glance. What makes it truly original is the "social-behavioral" approach of which it is a part, and, particularly, two ideas. The first is that the conversation in question is a conversation of gestures or attitudes, and the second, that thought and reflexive intelligence arise from the internalization of an external process supported by the social mechanism of communication: that of conduct organization. It imports then to understand what distinguishes such ideas from those of the founder of behavioral psychology, John B. Watson, for whom thinking amounts to nothing other than subvocal speech.

Study program for encapsulation materials interface for low cost silicon solar array

NASA Technical Reports Server (NTRS)

Kaelble, D. H.; Mansfeld, F. B.; Lunsden, J. B., III; Leung, C.

1980-01-01

An atmospheric corrosion model was developed and verified by five months of corrosion rate and climatology data acquired at the Mead, Nebraska LSA test site. Atmospheric corrosion rate monitors (ACM) show that moisture condensation probability and ionic conduction at the corroding surface or interface are controlling factors in corrosion rate. Protection of the corroding surface by encapsulant was shown by the ACM recordings to be maintained, independent of climatology, over the five months outdoor exposure period. The macroscopic corrosion processes which occur at Mead are shown to be reproduced in the climatology simulator. Controlled experiments with identical moisture and temperature aging cycles show that UV radiation causes corrosion while UV shielding inhibits LSA corrosion.

Mycosis inhibits cannibalism by Melanoplus sanguinipes, M. differentialis, Schistocerca americana, and Anabrus simplex

USDA-ARS?s Scientific Manuscript database

Cannibalism is common among the Acrididae and the Mormon cricket, Anabrus simplex, a tettigonid. These behaviors have been proposed as mechanisms for the horizontal transmission of Microsporida and entomopathogenic fungi. After anecdotal observations that Melanoplus sanguinipes and A. simplex did ...

Disparities in herpes simplex virus type 2 infection between black and white men who have sex with men in Atlanta, GA.

PubMed

Okafor, Netochukwu; Rosenberg, Eli S; Luisi, Nicole; Sanchez, Travis; del Rio, Carlos; Sullivan, Patrick S; Kelley, Colleen F

2015-09-01

HIV disproportionately affects black men who have sex with men, and herpes simplex virus type 2 is known to increase acquisition of HIV. However, data on racial disparities in herpes simplex virus type 2 prevalence and risk factors are limited among men who have sex with men in the United States. InvolveMENt was a cohort study of black and white HIV-negative men who have sex with men in Atlanta, GA. Univariate and multivariate cross-sectional associations with herpes simplex virus type 2 seroprevalence were assessed among 455 HIV-negative men who have sex with men for demographic, behavioural and social determinant risk factors using logistic regression. Seroprevalence of herpes simplex virus type 2 was 23% (48/211) for black and 16% (38/244) for white men who have sex with men (p = 0.05). Education, poverty, drug/alcohol use, incarceration, circumcision, unprotected anal intercourse, and condom use were not associated with herpes simplex virus type 2. In multivariate analyses, black race for those ≤25 years, but not >25 years, and number of sexual partners were significantly associated. Young black men who have sex with men are disproportionately affected by herpes simplex virus type 2, which may contribute to disparities in HIV acquisition. An extensive assessment of risk factors did not explain this disparity in herpes simplex virus type 2 infection suggesting differences in susceptibility or partner characteristics. © The Author(s) 2014.

Crustal structure between Lake Mead, Nevada, and Mono Lake, California

USGS Publications Warehouse

Johnson, Lane R.

1964-01-01

Interpretation of a reversed seismic-refraction profile between Lake Mead, Nevada, and Mono Lake, California, indicates velocities of 6.15 km/sec for the upper layer of the crust, 7.10 km/sec for an intermediate layer, and 7.80 km/sec for the uppermost mantle. Phases interpreted to be reflections from the top of the intermediate layer and the Mohorovicic discontinuity were used with the refraction data to calculate depths. The depth to the Moho increases from about 30 km near Lake Mead to about 40 km near Mono Lake. Variations in arrival times provide evidence for fairly sharp flexures in the Moho. Offsets in the Moho of 4 km at one point and 2 1/2 km at another correspond to large faults at the surface, and it is suggested that fracture zones in the upper crust may displace the Moho and extend into the upper mantle. The phase P appears to be an extension of the reflection from the top of the intermediate layer beyond the critical angle. Bouguer gravity, computed for the seismic model of the crust, is in good agreement with the measured Bouguer gravity. Thus a model of the crustal structure is presented which is consistent with three semi-independent sources of geophysical data: seismic-refraction, seismic-reflection, and gravity.

Inhibitory mechanism of l-glutamic acid on spawning of the starfish Patiria (Asterina) pectinifera.

PubMed

Mita, Masatoshi

2017-03-01

l-Glutamic acid was previously identified as an inhibitor of spawning in the starfish Patiria (Asterina) pectinifera; this study examined how l-glutamic acid works. Oocyte release from ovaries of P. pectinifera occurred after germinal vesicle breakdown (GVBD) and follicular envelope breakdown (FEBD) when gonads were incubated ex vivo with either relaxin-like gonad-stimulating peptide (RGP) or 1-methyladenine (1-MeAde). l-Glutamic acid blocked this spawning phenotype, causing the mature oocytes to remain within the ovaries. Neither RGP-induced 1-MeAde production in ovarian follicle cells nor 1-MeAde-induced GVBD and FEBD was affected by l-glutamic acid. l-Glutamic acid may act through metabotropic receptors in the ovaries to inhibit spawning, as l-(+)-2-amino-4-phosphonobutyric acid, an agonist for metabotropic glutamate receptors, also inhibited spawning induced by 1-MeAde. Application of acetylcholine (ACH) to ovaries under inhibitory conditions with l-glutamic acid, however, brought about spawning, possibly by inducing contraction of the ovarian wall to discharge mature oocytes from the ovaries concurrently with GVBD and FEBD. Thus, l-glutamic acid may inhibit ACH secretion from gonadal nerve cells in the ovary. Mol. Reprod. Dev. 84: 246-256, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

Novel measurement techniques (development and analysis of silicon solar cells near 20% effciency)

NASA Technical Reports Server (NTRS)

Wolf, M.; Newhouse, M.

1986-01-01

Work in identifying, developing, and analyzing techniques for measuring bulk recombination rates, and surface recombination velocities and rates in all regions of high-efficiency silicon solar cells is presented. The accuracy of the previously developed DC measurement system was improved by adding blocked interference filters. The system was further automated by writing software that completely samples the unkown solar cell regions with data of numerous recombination velocity and lifetime pairs. The results can be displayed in three dimensions and the best fit can be found numerically using the simplex minimization algorithm. Also described is a theoretical methodology to analyze and compare existing dynamic measurement techniques.

A Comparison of Trajectory Optimization Methods for the Impulsive Minimum Fuel Rendezvous Problem

NASA Technical Reports Server (NTRS)

Hughes, Steven P.; Mailhe, Laurie M.; Guzman, Jose J.

2002-01-01

In this paper we present a comparison of optimization approaches to the minimum fuel rendezvous problem. Both indirect and direct methods are compared for a variety of test cases. The indirect approach is based on primer vector theory. The direct approaches are implemented numerically and include Sequential Quadratic Programming (SQP), Quasi-Newton, Simplex, Genetic Algorithms, and Simulated Annealing. Each method is applied to a variety of test cases including, circular to circular coplanar orbits, LEO to GEO, and orbit phasing in highly elliptic orbits. We also compare different constrained optimization routines on complex orbit rendezvous problems with complicated, highly nonlinear constraints.

Novel measurement techniques (development and analysis of silicon solar cells near 20% effciency)

NASA Astrophysics Data System (ADS)

Wolf, M.; Newhouse, M.

Work in identifying, developing, and analyzing techniques for measuring bulk recombination rates, and surface recombination velocities and rates in all regions of high-efficiency silicon solar cells is presented. The accuracy of the previously developed DC measurement system was improved by adding blocked interference filters. The system was further automated by writing software that completely samples the unkown solar cell regions with data of numerous recombination velocity and lifetime pairs. The results can be displayed in three dimensions and the best fit can be found numerically using the simplex minimization algorithm. Also described is a theoretical methodology to analyze and compare existing dynamic measurement techniques.

Two Aspects of the Simplex Model: Goodness of Fit to Linear Growth Curve Structures and the Analysis of Mean Trends.

ERIC Educational Resources Information Center

Mandys, Frantisek; Dolan, Conor V.; Molenaar, Peter C. M.

1994-01-01

Studied the conditions under which the quasi-Markov simplex model fits a linear growth curve covariance structure and determined when the model is rejected. Presents a quasi-Markov simplex model with structured means and gives an example. (SLD)

Hydrocephalus in herpes simplex type 2 meningitis.

PubMed

Yap, Elaine; Ellis-Pegler, Rod

2006-08-01

A 34-year-old woman presented to hospital with symptoms of meningitis, later confirmed to be due to herpes simplex virus type 2. She developed hydrocephalus on day 2 of her admission. We describe the first case of hydrocephalus associated with herpes simplex type 2 meningitis in an adult.

Optimization of the gypsum-based materials by the sequential simplex method

NASA Astrophysics Data System (ADS)

Doleželová, Magdalena; Vimmrová, Alena

2017-11-01

The application of the sequential simplex optimization method for the design of gypsum based materials is described. The principles of simplex method are explained and several examples of the method usage for the optimization of lightweight gypsum and ternary gypsum based materials are given. By this method lightweight gypsum based materials with desired properties and ternary gypsum based material with higher strength (16 MPa) were successfully developed. Simplex method is a useful tool for optimizing of gypsum based materials, but the objective of the optimization has to be formulated appropriately.

Reactivation of latent herpes simplex virus infection by ultraviolet light: a human model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Perna, J.J.; Mannix, M.L.; Rooney, J.F.

1987-09-01

Infection with herpes simplex virus often results in a latent infection of local sensory ganglia and a disease characterized by periodic viral reactivation and mucocutaneous lesions. The factors that trigger reactivation in humans are still poorly defined. In our study, five patients with documented histories of recurrent herpes simplex virus infection on the buttocks or sacrum were exposed to three times their minimal erythema dose of ultraviolet light. Site-specific cutaneous herpes simplex virus infection occurred at 4.4 +/- 0.4 days after exposure to ultraviolet light in 8 of 13 attempts at reactivation. We conclude that ultraviolet light can reactivate herpesmore » simplex virus under experimentally defined conditions. This model in humans should prove useful in evaluating the pathophysiology and prevention of viral reactivation.« less

Reactivation of latent herpes simplex virus infection by ultraviolet light: a human model.

PubMed

Perna, J J; Mannix, M L; Rooney, J F; Notkins, A L; Straus, S E

1987-09-01

Infection with herpes simplex virus often results in a latent infection of local sensory ganglia and a disease characterized by periodic viral reactivation and mucocutaneous lesions. The factors that trigger reactivation in humans are still poorly defined. In our study, five patients with documented histories of recurrent herpes simplex virus infection on the buttocks or sacrum were exposed to three times their minimal erythema dose of ultraviolet light. Site-specific cutaneous herpes simplex virus infection occurred at 4.4 +/- 0.4 days after exposure to ultraviolet light in 8 of 13 attempts at reactivation. We conclude that ultraviolet light can reactivate herpes simplex virus under experimentally defined conditions. This model in humans should prove useful in evaluating the pathophysiology and prevention of viral reactivation.

Expression of IFN-Inducible Genes with Antiviral Function OAS1 and MX1 in Health and under Conditions of Recurrent Herpes Simplex Infection.

PubMed

Karaulov, A V; Shulzhenko, A E; Karsonova, A V

2017-07-01

We studied the expression of IFN-inducible genes OAS1 and Mx1 in lysates of peripheral blood mononuclear cells from patients suffering from recurrent Herpes simplex infections in comparison with healthy people. To induce the expression of the studied genes, blood mononuclears were incubated with recombinant IFN-α2b in concentrations of 1, 10, and 100 U/ml for 3 h and then the content of the studied transcripts was evaluated. Relative expression of OAS1 and Mx1 in patients with recurrent forms of Herpes simplex both during the acute stage and clinical remission did not differ significantly from that in healthy people after stimulation with IFN-α2b in a concentration of 1 U/ml and in higher concentrations (10 and 100 U/ml). It was concluded that intracellular signal transduction in IFN-α-activated cells in vitro was not disturbed in patients with recurrent forms of Herpes simplex infection. Thus, the reported phenomenon of IFN-signalling distortion by Herpes simplex virus proteins observed in experiments on model cell lines infected with Herpes simplex virus was not confirmed in our experiments on peripheral blood mononuclear cells from patients with Herpes simplex infection.

Psychosis in a 15-Year-Old Female with Herpes Simplex Encephalitis in a Background of Mannose-Binding Lecithin Deficiency.

PubMed

Asogwa, Kenneth; Buabeng, Kwame; Kaur, Amarjit

2017-01-01

Historically, psychotic disorder has been associated with viral infection. Herpes simplex infections and Epstein-Barr virus (EBV) among other viral infections have been implicated in psychotic disorder. Of note in this case report is psychotic disorder that occurred following reactivation of herpes simplex infection in a background of mannose-binding lecithin (MBL) deficiency, childhood EBV infection, and severe psychosocial stress. Herpes simplex encephalitis (HSE) remains a significant cause of morbidity and mortality despite advancement in its treatment with intravenous acyclovir. Many studies have reported psychiatric and neurological manifestation of herpes simplex infection following primary or reactivated infection, while others suggest milder clinical course of herpes simplex encephalitis in a background of immunosuppression. Another contributory factor to psychotic disorder in this case is childhood EBV exposure which has been reported to increase the risk of psychosis in adolescence and adulthood. This case report describes a 15-year-old female with MBL deficiency who presented with psychosis caused by reactivated herpes simplex infection and had good clinical recovery. Based on childhood Epstein-Barr virus exposure and psychosis in adolescence (current case), she is at increased risk of psychotic disorder in adulthood, which underscores the importance of long-term monitoring.

Constraining the age and magnitude of uplift in the northern National Petroleum Reserve in Alaska (NPRA)-apatite fission-track analysis of samples from three wells

USGS Publications Warehouse

Houseknecht, David W.; Bird, Kenneth J.; O'Sullivan, Paul

2011-01-01

A broad, post-mid-Cretaceous uplift is defined in the northern National Petroleum Reserve in Alaska (NPRA) by regional truncation of Cretaceous strata, thermal maturity patterns, and amounts of exhumation estimated from sonic logs. Apatite fission-track (AFT) analysis of samples from three wells (South Meade No. 1, Topagoruk No. 1, and Ikpikpuk No. 1) across the eastern flank of the uplift indicates Tertiary cooling followed by Quaternary heating. Results from all three wells indicate that cooling, presumably caused by uplift and erosion, started about 75-65 Ma (latest Cretaceous-earliest Tertiary) and continued through the Tertiary Period. Data from South Meade indicate more rapid cooling after about 35-15 Ma (latest Eocene-middle Miocene) followed by a significant increase in subsurface temperature during the Quaternary, probably the result of increased heat flow. Data from Topagoruk and Ikpikpuk include subtle evidence of accelerated cooling starting in the latest Eocene-middle Miocene and possible evidence of increased temperature during the Quaternary. Subsurface temperature perturbations related to the insulating effect of permafrost may have been responsible for the Quaternary temperature increase at Topagoruk and Ikpikpuk and may have been a contributing factor at South Meade. Multiple lines of geologic evidence suggest that the magnitude of exhumation resulting from uplift and erosion is 5,000-6,500 ft at South Meade, 4,000-5,500 ft at Topagoruk, and 2,500-4,000 ft at Ikpikpuk. The results from these wells help to define the broad geometry of the uplift, which increases in magnitude from less than 1,000 ft at the Colville River delta to perhaps more than 7,000 ft along the northwestern coast of NPRA, between Point Barrow and Peard Bay. Neither the origin nor the offshore extent of the uplift, west and north of the NPRA coast, have been determined.

Determining residual reduction algorithm kinematic tracking weights for a sidestep cut via numerical optimization.

PubMed

Samaan, Michael A; Weinhandl, Joshua T; Bawab, Sebastian Y; Ringleb, Stacie I

2016-12-01

Musculoskeletal modeling allows for the determination of various parameters during dynamic maneuvers by using in vivo kinematic and ground reaction force (GRF) data as inputs. Differences between experimental and model marker data and inconsistencies in the GRFs applied to these musculoskeletal models may not produce accurate simulations. Therefore, residual forces and moments are applied to these models in order to reduce these differences. Numerical optimization techniques can be used to determine optimal tracking weights of each degree of freedom of a musculoskeletal model in order to reduce differences between the experimental and model marker data as well as residual forces and moments. In this study, the particle swarm optimization (PSO) and simplex simulated annealing (SIMPSA) algorithms were used to determine optimal tracking weights for the simulation of a sidestep cut. The PSO and SIMPSA algorithms were able to produce model kinematics that were within 1.4° of experimental kinematics with residual forces and moments of less than 10 N and 18 Nm, respectively. The PSO algorithm was able to replicate the experimental kinematic data more closely and produce more dynamically consistent kinematic data for a sidestep cut compared to the SIMPSA algorithm. Future studies should use external optimization routines to determine dynamically consistent kinematic data and report the differences between experimental and model data for these musculoskeletal simulations.

Geohydrologic reconnaissance of Lake Mead National Recreation Area; Las Vegas Wash to Opal Mountain, Nevada

USGS Publications Warehouse

Laney, R.L.

1981-01-01

The study is a geohydrologic reconnaissance of about 170 square miles in the Lake Mead National Recreation Area from Las Vegas Wash to Opal Mountain, Nevada. The study is one of a series that describes the geohydrology of the recreation area and that indentifies areas where water supplies can be developed. Precipitation in this arid area is about 5 inches per year. Streamflow is seasonal and extremely variable except for that in the Colorado River, which adjoins the area. Pan evaporation is more than 20 times greater than precipitation; therefore, regional ground-water supplies are meager except near the Colorado River, Lake Mead, and Lake Mohave. Large ground-water supplies can be developed near the river and lakes, and much smaller supplies may be obtained in a few favorable locations farther from the river and lakes. Ground water in most of the areas probably contains more than 1,000 milligrams per liter of dissolved solids, but water that contains less than 1,000 milligrams per liter of dissolved solids can be obtained within about 1 mile of the lakes. Crystalline rocks of metamorphic, intrusive and volcanic origin crop out in the area. These rocks are overlain by conglomerate and mudstone of the Muddy Creek Formation, gravel and conglomerate of the older alluvium, and sand and gravel of the Chemehuevi Formation and younger alluvium. The crystalline rocks, where sufficiently fractured, yield water to springs and would yield small amounts of water to favorably located wells. The poorly cemented and more permeable beds of the older alluvium, Chemehuevi Formation, and younger alluvium are the better potential aquifers, particularly along the Colorado River and Lakes Mead and Mohave. Thermal springs in the gorge of the Colorado River south of Hoover Dam discharge at least 2,580 acre-feet per year of water from the volcanic rocks and metamorphic and plutonic rocks. The discharge is much greater than could be infiltrated in the drainage basin above the springs. Transbasin movement of ground water probably occurs , and perhaps the larger part of the spring discharge is underflow from Eldorado Valley. The more favorable sites for ground-water development are along the shores of Lakes Mead and Mohave and are the Fire Mountain, Opal Mountain to Aztec Wash, and Hemenway Wash sites. Wells yielding several hundred gallons per minute of water of acceptable chemical quality can be developed at these sites. (USGS)

Using Multi-Objective Optimization to Explore Robust Policies in the Colorado River Basin

NASA Astrophysics Data System (ADS)

Alexander, E.; Kasprzyk, J. R.; Zagona, E. A.; Prairie, J. R.; Jerla, C.; Butler, A.

2017-12-01

The long term reliability of water deliveries in the Colorado River Basin has degraded due to the imbalance of growing demand and dwindling supply. The Colorado River meanders 1,450 miles across a watershed that covers seven US states and Mexico and is an important cultural, economic, and natural resource for nearly 40 million people. Its complex operating policy is based on the "Law of the River," which has evolved since the Colorado River Compact in 1922. Recent (2007) refinements to address shortage reductions and coordinated operations of Lakes Powell and Mead were negotiated with stakeholders in which thousands of scenarios were explored to identify operating guidelines that could ultimately be agreed on. This study explores a different approach to searching for robust operating policies to inform the policy making process. The Colorado River Simulation System (CRSS), a long-term water management simulation model implemented in RiverWare, is combined with the Borg multi-objective evolutionary algorithm (MOEA) to solve an eight objective problem formulation. Basin-wide performance metrics are closely tied to system health through incorporating critical reservoir pool elevations, duration, frequency and quantity of shortage reductions in the objective set. For example, an objective to minimize the frequency that Lake Powell falls below the minimum power pool elevation of 3,490 feet for Glen Canyon Dam protects a vital economic and renewable energy source for the southwestern US. The decision variables correspond to operating tiers in Lakes Powell and Mead that drive the implementation of various shortage and release policies, thus affecting system performance. The result will be a set of non-dominated solutions that can be compared with respect to their trade-offs based on the various objectives. These could inform policy making processes by eliminating dominated solutions and revealing robust solutions that could remain hidden under conventional analysis.

Simulations of Flame Acceleration and DDT in Mixture Composition Gradients

NASA Astrophysics Data System (ADS)

Zheng, Weilin; Kaplan, Carolyn; Houim, Ryan; Oran, Elaine

2017-11-01

Unsteady, multidimensional, fully compressible numerical simulations of methane-air in an obstructed channel with spatial gradients in equivalence ratios have been carried to determine the effects of the gradients on flame acceleration and transition to detonation. Results for gradients perpendicular to the propagation direction were considered here. A calibrated, optimized chemical-diffusive model that reproduces correct flame and detonation properties for methane-air over a range of equivalence ratios was derived from a combination of a genetic algorithm with a Nelder-Mead optimization scheme. Inhomogeneous mixtures of methane-air resulted in slower flame acceleration and longer distance to DDT. Detonations were more likely to decouple into a flame and a shock under sharper concentration gradients. Detailed analyses of temperature and equivalence ratio illustrated that vertical gradients can greatly affect the formation of hot spots that initiate detonation by changing the strength of leading shock wave and local equivalence ratio near the base of obstacles. This work is supported by the Alpha Foundation (Grant No. AFC215-20).

Diffraction-limited lucky imaging with a 12" commercial telescope

NASA Astrophysics Data System (ADS)

Baptista, Brian J.

2014-08-01

Here we demonstrate a novel lucky imaging camera which is designed to produce diffraction-limited imaging using small telescopes similar to ones used by many academic institutions for outreach and/or student training. We present a design that uses a Meade 12" SCT paired with an Andor iXon fast readout EMCCD. The PSF of the telescope is matched to the pixel size of the EMCCD by adding a simple, custom-fabricated, intervening optical system. We demonstrate performance of the system by observing both astronomical and terrestrial targets. The astronomical application requires simpler data reconstruction techniques as compared to the terrestrial case. We compare different lucky imaging registration and reconstruction algorithms for use with this imager for both astronomical and terrestrial targets. We also demonstrate how this type of instrument would be useful for both undergraduate and graduate student training. As an instructional aide, the instrument can provide a hands-on approach for teaching instrument design, standard data reduction techniques, lucky imaging data processing, and high resolution imaging concepts.

Prodrugs of herpes simplex thymidine kinase inhibitors.

PubMed

Yanachkova, Milka; Xu, Wei-Chu; Dvoskin, Sofya; Dix, Edward J; Yanachkov, Ivan B; Focher, Federico; Savi, Lida; Sanchez, M Dulfary; Foster, Timothy P; Wright, George E

2015-04-01

Because guanine-based herpes simplex virus thymidine kinase inhibitors are not orally available, we synthesized various 6-deoxy prodrugs of these compounds and evaluated them with regard to solubility in water, oral bioavailability, and efficacy to prevent herpes simplex virus-1 reactivation from latency in a mouse model. Organic synthesis was used to prepare compounds, High Performance Liquid Chromatography (HPLC) to analyze hydrolytic conversion, Mass Spectrometry (MS) to measure oral bioavailability, and mouse latent infection and induced reactivation to evaluate the efficacy of a specific prodrug. Aqueous solubilities of prodrugs were improved, oxidation of prodrugs by animal cytosols occurred in vitro, and oral absorption of the optimal prodrug sacrovir™ (6-deoxy-mCF3PG) in the presence of the aqueous adjuvant Soluplus® and conversion to active compound N(2)-[3-(trifluoromethyl)pheny])guanine (mCF3PG) were accomplished in mice. Treatment of herpes simplex virus-1 latent mice with sacrovir™ in 1% Soluplus in drinking water significantly suppressed herpes simplex virus-1 reactivation and viral genomic replication. Ad libitum oral delivery of sacrovir™ was effective in suppressing herpes simplex virus-1 reactivation in ocularly infected latent mice as measured by the numbers of mice shedding infectious virus at the ocular surface, numbers of trigeminal ganglia positive for infectious virus, number of corneas that had detectable infectious virus, and herpes simplex virus-1 genome copy numbers in trigeminal ganglia following reactivation. These results demonstrate the statistically significant effect of the prodrug on suppressing herpes simplex virus-1 reactivation in vivo. © The Author(s) 2015.

Advancing Paternal Age and Simplex Autism

ERIC Educational Resources Information Center

Puleo, Connor Morrow; Schmeidler, James; Reichenberg, Abraham; Kolevzon, Alexander; Soorya, Latha V.; Buxbaum, Joseph D.; Silverman, Jeremy M.

2012-01-01

De novo events appear more common in female and simplex autism spectrum disorder (ASD) cases and may underlie greater ASD risk in older fathers' offspring. This study examined whether advancing paternal age predicts an increase in simplex (n = 90) versus multiplex ASD cases (n = 587) in 677 participants (340 families). Whether or not controlling…

Yager’s ranking method for solving the trapezoidal fuzzy number linear programming

NASA Astrophysics Data System (ADS)

Karyati; Wutsqa, D. U.; Insani, N.

2018-03-01

In the previous research, the authors have studied the fuzzy simplex method for trapezoidal fuzzy number linear programming based on the Maleki’s ranking function. We have found some theories related to the term conditions for the optimum solution of fuzzy simplex method, the fuzzy Big-M method, the fuzzy two-phase method, and the sensitivity analysis. In this research, we study about the fuzzy simplex method based on the other ranking function. It is called Yager's ranking function. In this case, we investigate the optimum term conditions. Based on the result of research, it is found that Yager’s ranking function is not like Maleki’s ranking function. Using the Yager’s function, the simplex method cannot work as well as when using the Maleki’s function. By using the Yager’s function, the value of the subtraction of two equal fuzzy numbers is not equal to zero. This condition makes the optimum table of the fuzzy simplex table is undetected. As a result, the simplified fuzzy simplex table becomes stopped and does not reach the optimum solution.

Biocontrol of Pathogens in the Meat Chain

NASA Astrophysics Data System (ADS)

Burgess, Catherine M.; Rivas, Lucia; McDonnell, Mary J.; Duffy, Geraldine

Bacterial foodborne zoonotic diseases are of major concern, impacting public health and causing economic losses for the agricultural-food sector and the wider society. In the United States (US) alone foodborne illness from pathogens is responsible for 76 million cases of illnesses each year (Mead et al., 1999). Salmonella, Campylobacter jejuni and Enterohaemorraghic Escherichia coli (EHEC; predominately serotype O157:H7) and Listeria monocytogenes are the most predominant foodborne bacterial pathogens reported in the developed world (United States Department of Agriculture, 2001). The importance of meat and meat products as a vehicle of foodborne zoonotic pathogens cannot be underestimated (Center for Disease Control, 2006; Gillespie, O’Brien, Adak, Cheasty, & Willshaw, 2005; Mazick, Ethelberg, Nielsen, Molbak, & Lisby, 2006; Mead et al., 2006).

Development of an Accelerated Test Design for Predicting the Service Life of the Solar Array at Mead, Nebraska

NASA Technical Reports Server (NTRS)

Gaines, G. B.; Thomas, R. E.; Noel, G. T.; Shilliday, T. S.; Wood, V. E.; Carmichael, D. C.

1979-01-01

Potential long-term degradation modes for the two types of modules in the Mead array were determined and judgments were made as to those environmental stresses and combinations of stresses which accelerate the degradation of the power output. Hierarchical trees representing the severity of effects of stresses (test conditions) on eleven individual degradation modes were constructed and were pruned of tests judged to be nonessential. Composites of those trees were developed so that there is now one pruned tree covering eight degradation modes, another covering two degradation modes, and a third covering one degradation mode. These three composite trees form the basis for selection of test conditions in the final test plan which is now being prepared.

Shrinkage simplex-centroid designs for a quadratic mixture model

NASA Astrophysics Data System (ADS)

Hasan, Taha; Ali, Sajid; Ahmed, Munir

2018-03-01

A simplex-centroid design for q mixture components comprises of all possible subsets of the q components, present in equal proportions. The design does not contain full mixture blends except the overall centroid. In real-life situations, all mixture blends comprise of at least a minimum proportion of each component. Here, we introduce simplex-centroid designs which contain complete blends but with some loss in D-efficiency and stability in G-efficiency. We call such designs as shrinkage simplex-centroid designs. Furthermore, we use the proposed designs to generate component-amount designs by their projection.

75 FR 13144 - South Dakota Disaster #SD-00028

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-18

.... Small Business Administration, Processing and Disbursement Center, 14925 Kingsport Road, Fort Worth, TX..., Hyde, Jerauld, Mccook, Mcpherson, Meade, Perkins, Potter, Roberts, Sully, Turner, Walworth, Ziebach...

75 FR 32820 - Kentucky Disaster Number KY-00032

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-09

.... Small Business Administration, Processing and Disbursement Center, 14925 Kingsport Road, Fort Worth, TX..., Marshall, Mccracken, Mclean, Meade, Trigg, Union, Webster. Illinois: Hardin, Massac, Pope. Indiana...

Association between Psychopathic Disorder and Serum Antibody to Herpes Simplex Virus (Type 1)

PubMed Central

Cleobury, J. F.; Skinner, G. R. B.; Thouless, M. E.; Wildy, P.

1971-01-01

The sera of a small of patients has been examined for herpes simplex virus antibody. Three clinically-defined groups of patients were compared: (a) aggressive psychopaths, (b) psychiatric controls, and (c) general hospital patients. The first group had an unusually high average kinetic neutralization constant against type 1 herpes simplex virus. PMID:5543996

Association between psychopathic disorder and serum antibody to herpes simplex virus (type 1).

PubMed

Cleobury, J F; Skinner, G R; Thouless, M E; Wildy, P

1971-02-20

The sera of a small of patients has been examined for herpes simplex virus antibody. Three clinically-defined groups of patients were compared: (a) aggressive psychopaths, (b) psychiatric controls, and (c) general hospital patients. The first group had an unusually high average kinetic neutralization constant against type 1 herpes simplex virus.

Detection of herpes simplex virus-specific DNA sequences in latently infected mice and in humans.

PubMed

Efstathiou, S; Minson, A C; Field, H J; Anderson, J R; Wildy, P

1986-02-01

Herpes simplex virus-specific DNA sequences have been detected by Southern hybridization analysis in both central and peripheral nervous system tissues of latently infected mice. We have detected virus-specific sequences corresponding to the junction fragment but not the genomic termini, an observation first made by Rock and Fraser (Nature [London] 302:523-525, 1983). This "endless" herpes simplex virus DNA is both qualitatively and quantitatively stable in mouse neural tissue analyzed over a 4-month period. In addition, examination of DNA extracted from human trigeminal ganglia has shown herpes simplex virus DNA to be present in an "endless" form similar to that found in the mouse model system. Further restriction enzyme analysis of latently infected mouse brainstem and human trigeminal DNA has shown that this "endless" herpes simplex virus DNA is present in all four isomeric configurations.

Detection of herpes simplex virus-specific DNA sequences in latently infected mice and in humans.

PubMed Central

Efstathiou, S; Minson, A C; Field, H J; Anderson, J R; Wildy, P

1986-01-01

Herpes simplex virus-specific DNA sequences have been detected by Southern hybridization analysis in both central and peripheral nervous system tissues of latently infected mice. We have detected virus-specific sequences corresponding to the junction fragment but not the genomic termini, an observation first made by Rock and Fraser (Nature [London] 302:523-525, 1983). This "endless" herpes simplex virus DNA is both qualitatively and quantitatively stable in mouse neural tissue analyzed over a 4-month period. In addition, examination of DNA extracted from human trigeminal ganglia has shown herpes simplex virus DNA to be present in an "endless" form similar to that found in the mouse model system. Further restriction enzyme analysis of latently infected mouse brainstem and human trigeminal DNA has shown that this "endless" herpes simplex virus DNA is present in all four isomeric configurations. Images PMID:3003377

Reservoir-induced deformation and continental rheology in vicinity of Lake Mead, Nevada

NASA Astrophysics Data System (ADS)

Kaufmann, Georg; Amelung, Falk

2000-07-01

Lake Mead is a large reservoir in Nevada, formed by the construction of the 221-m-high Hoover Dam in the Black Canyon of the Colorado River. The lake encompasses an area of 635 km2, and the total volume of the reservoir is 35.5 km3. Filling started in February 1935. On the basis of a first-order leveling in 1935, several levelings were carried out to measure the deformation induced by the load of the reservoir. Subsidence in the central parts of the lake relative to the first leveling was around 120 mm (1941), 218 mm (1950), and 200 mm (1963). The subsidence pattern clearly shows relaxation of the underlying basement due to the water load of the lake, which ceased after 1950. Modeling of the relaxation process by means of layered, viscoelastic, compressible flat Earth models with a detailed representation of the spatial and temporal distribution of the water load shows that the thickness of the elastic crust underneath Lake Mead is 30±3 km. The data are also consistent with a 10-km-thick elastic upper crust and a 20-km-thick viscoelastic lower crust, with 1020 Pa s as a lower bound for its viscosity. The subcrust has an average viscosity of 1018±0.2 Pa s, a surprisingly low value. The leveling data constrain the viscosity profile down to ˜200 km depth.

Gondolellid conodonts and depositional setting of the Phosphoria Formation

USGS Publications Warehouse

Wardlaw, Bruce R.

2015-01-01

The Phosphoria Formation and related rocks were deposited over an 8.9 m.y. interval beginning approximately 274.0Ma and ending approximately 265.1Ma. The Meade Peak Phosphatic Shale Member was deposited in southeastern Idaho and adjacent Wyoming over 5.4 m.y. from approximately 273.2 to 268.6 Ma. The Retort Phosphatic Shale Member was deposited in southwestern Montana and west-central Wyoming over 1.3 m.y. from approximately 267.4 to 266.1Ma. The base of the Roadian Stage of the Middle Permian occurs within the lower phosphate zone of the Meade Peak. The base of the Wordian Stage occurs within the upper phosphate zone of the Meade Peak. The presence of a cool-water brachiopod fauna, cool-water conodont faunas, and the absence of fusulinids throughout the Phosphoria basin indicate the presence of pervasive cool, upwelling waters. Acritarchs are intimately associated with phosphorites and phosphatic shales and may have been the primary organic producer to help drive phosphate production. The gondolellid conodont fauna of the Phosphoria Formation links a geographic cline of Jinogondolella nankingensis from the Delaware basin, West Texas, to the Sverdrup basin, Canadian Arctic, and shows distinct differentiation in species distribution, as do other conodont groups, within the Phosphoria basin. Ten species and two subspecies of gondolellid conodonts are recognized from the Phosphoria Formation and related rocks that belong to Mesogondolella and Jinogondolella.

Herpes Simplex Encephalitis during Treatment with Tumor Necrosis Factor-α Inhibitors

PubMed Central

Bradford, Russell D.; Pettit, April C.; Wright, Patty W.; Mulligan, Mark J.; Moreland, Larry W.; McLain, David A.; Gnann, John W.; Bloch, Karen C.

2012-01-01

We report 3 cases of herpes simplex virus encephalitis in patients receiving tumor necrosis factor-alpha (TNF-α) inhibitors for rheumatologic disorders. Although TNF-α inhibitors have been reported to increase the risk of other infectious diseases, to our knowledge, an association between anti–TNF-α drugs and herpes simplex virus encephalitis has not been previously described. PMID:19681709

Comparison of Full and Partial Admission Flow Fields in the Simplex Turbine

NASA Technical Reports Server (NTRS)

Dorney, Daniel J.; Griffin, Lisa W.; Sondak, Douglas L.

2001-01-01

The objectives of this project were to: (1) determine the effects of partial admission flow on rotor performance as a function of circumferential location and on unsteady rotor loading; and (2) Provide an efficient technique for determining turbine performance. Full admission simulation ws performed for the Simplex turbine and partial admission simulation is underway for the Simplex turbine.

Herpes simplex encephalitis with thalamic, brainstem and cerebellar involvement.

PubMed

Garg, Meenal; Kulkarni, Shilpa; Udwadia Hegde, Anaita

2018-04-01

Herpes simplex virus encephalitis is a common and treatable cause of acute encephalitis in all age groups. Certain radiological features such as temporal parenchymal involvement facilitate the diagnosis. The use of herpes simplex virus polymerase chain reaction has expanded the clinical and imaging spectrum. We report the case of a young patient who presented with a movement disorder and predominant involvement of thalami, brainstem and cerebellum on magnetic resonance imaging, and was diagnosed with herpes simplex virus encephalitis. Differentiation from Japanese encephalitis may be difficult in these patients, especially in endemic areas, and may necessitate the use of relevant investigations in all patients.

Herpes simplex virus type 2 (Mollaret's) meningitis: a case report.

PubMed

Abu Khattab, Mohammed; Al Soub, Hussam; Al Maslamani, Mona; Al Khuwaiter, Jameela; El Deeb, Yasser

2009-11-01

Mollaret's meningitis is an unusual and under-appreciated syndrome of benign, recurrent aseptic meningitis. The available literature indicates that the causative agent is herpes simplex virus type 2 (HSV-2) in the majority of cases and much less frequently herpes simplex virus type 1 (HSV-1). We report the case of a 49-year-old Indian female who had four attacks of recurrent lymphocytic meningitis (Mollaret's meningitis) occurring over a 7-year period. The diagnosis of herpes simplex meningitis was made at the time of the fourth episode by a positive PCR for herpes simplex virus infection in the cerebrospinal fluid. During the first three episodes, the patient was treated with anti-tuberculous drugs and antibiotics for bacterial meningitis; however for the last episode, once the diagnosis of herpes simplex meningitis was confirmed, only symptomatic treatment was given. No long-term suppressive therapy was given and no recurrence has been experienced so far. Mollaret's meningitis should be suspected in all cases of recurrent lymphocytic meningitis. Early diagnosis may prevent prolonged hospital admissions, unnecessary investigations, and exposure to unnecessary medications, with the associated considerable costs. Treatment with acyclovir may be beneficial in decreasing the severity and duration of attacks and in preventing further episodes. [Au?1].

76 FR 19978 - Procurement List; Proposed Addition

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-11

... Location: Base Operation Support Service, Department of Public Works, Fort George D. Meade, MD. NPA..., Mission and Installation Contracting Command, Fort Eustis, VA. End of Certification Patricia Briscoe...

Geophysicists

NASA Astrophysics Data System (ADS)

2004-06-01

In Memoriam: James R. Holton, Buford K. Meade, Mikhail I. Pudovkin; Honors: Michel Blanc, Alberto Borges, Paola Vannucchi, Michael A. Hapgood, Subir Banerjee, Lev Vinnik, John Wahr, Forrest Mozer, Vladimir N. Zharkov, Michael Ghil

Conic Sampling: An Efficient Method for Solving Linear and Quadratic Programming by Randomly Linking Constraints within the Interior

PubMed Central

Serang, Oliver

2012-01-01

Linear programming (LP) problems are commonly used in analysis and resource allocation, frequently surfacing as approximations to more difficult problems. Existing approaches to LP have been dominated by a small group of methods, and randomized algorithms have not enjoyed popularity in practice. This paper introduces a novel randomized method of solving LP problems by moving along the facets and within the interior of the polytope along rays randomly sampled from the polyhedral cones defined by the bounding constraints. This conic sampling method is then applied to randomly sampled LPs, and its runtime performance is shown to compare favorably to the simplex and primal affine-scaling algorithms, especially on polytopes with certain characteristics. The conic sampling method is then adapted and applied to solve a certain quadratic program, which compute a projection onto a polytope; the proposed method is shown to outperform the proprietary software Mathematica on large, sparse QP problems constructed from mass spectometry-based proteomics. PMID:22952741

Minimization of transverse beam-emittance growth in the 90-degree bending section of the RAON rare-isotope accelerator

NASA Astrophysics Data System (ADS)

Oh, B. H.; Yoon, M.

2016-11-01

The major contribution of the transverse beam emittance growth (EG) in a RAON heavy-ion accelerator comes from the bending section, which consists of a charge-stripping section, a matching section, and a charge-selection section in sequence. In this paper, we describe our research to minimize the two-dimensional EG in the 90-degree bending section of the RAON currently being developed in Korea. The EG minimization was achieved with the help of multi-objective genetic algorithms and the simplex method. We utilized those algorithms to analyze the 90-degree bending section in a driver linac for the in-flight fragmentation system. Horizontal and vertical EGs were limited to below 10 % in the bending section by adjustment of the transverse beam optics upstream from the charge-stripping section, redesign of the charge-selection section, and optimization of the vertical beam optics at the entrance of a charge-selection section.

On the efficiency of a randomized mirror descent algorithm in online optimization problems

NASA Astrophysics Data System (ADS)

Gasnikov, A. V.; Nesterov, Yu. E.; Spokoiny, V. G.

2015-04-01

A randomized online version of the mirror descent method is proposed. It differs from the existing versions by the randomization method. Randomization is performed at the stage of the projection of a subgradient of the function being optimized onto the unit simplex rather than at the stage of the computation of a subgradient, which is common practice. As a result, a componentwise subgradient descent with a randomly chosen component is obtained, which admits an online interpretation. This observation, for example, has made it possible to uniformly interpret results on weighting expert decisions and propose the most efficient method for searching for an equilibrium in a zero-sum two-person matrix game with sparse matrix.

Phase I archaeological survey of the proposed timber harvest areas in traininq areas 8, 13, and 14 on the Fort Knox Military Reservation, Hardin and Meade Counties, Kentucky. Final report, June-July 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schenian, P.A.

1995-07-01

In June and July 1995, the Fort Knox Contract Staff Archaeologist conducted a Phase I archaeological survey of proposed timber harvest areas in Training Areas 8, 13, and 14 on the Fort Knox Military Reservation, Hardin and Meade Counties, Kentucky. The timber areas consist of five small, disjoint project areas encompassing a total of 11 acres (4.4 ha). The trees to be harvested had been marked by the forestry section prior to the survey. All timber areas were walked in their entirety. No evidence of archaeological sites was found in this study. It is recommended that the timber harvesting bemore » conducted as proposed.« less

PCE: web tools to compute protein continuum electrostatics

PubMed Central

Miteva, Maria A.; Tufféry, Pierre; Villoutreix, Bruno O.

2005-01-01

PCE (protein continuum electrostatics) is an online service for protein electrostatic computations presently based on the MEAD (macroscopic electrostatics with atomic detail) package initially developed by D. Bashford [(2004) Front Biosci., 9, 1082–1099]. This computer method uses a macroscopic electrostatic model for the calculation of protein electrostatic properties, such as pKa values of titratable groups and electrostatic potentials. The MEAD package generates electrostatic energies via finite difference solution to the Poisson–Boltzmann equation. Users submit a PDB file and PCE returns potentials and pKa values as well as color (static or animated) figures displaying electrostatic potentials mapped on the molecular surface. This service is intended to facilitate electrostatics analyses of proteins and thereby broaden the accessibility to continuum electrostatics to the biological community. PCE can be accessed at . PMID:15980492

Inner tegument proteins of Herpes Simplex Virus are sufficient for intracellular capsid motility in neurons but not for axonal targeting

PubMed Central

Müller, Oliver; Ivanova, Lyudmila; Bialy, Dagmara; Pohlmann, Anja; Binz, Anne; Hegemann, Maike; Viejo-Borbolla, Abel; Rosenhahn, Bodo; Bauerfeind, Rudolf; Sodeik, Beate

2017-01-01

Upon reactivation from latency and during lytic infections in neurons, alphaherpesviruses assemble cytosolic capsids, capsids associated with enveloping membranes, and transport vesicles harboring fully enveloped capsids. It is debated whether capsid envelopment of herpes simplex virus (HSV) is completed in the soma prior to axonal targeting or later, and whether the mechanisms are the same in neurons derived from embryos or from adult hosts. We used HSV mutants impaired in capsid envelopment to test whether the inner tegument proteins pUL36 or pUL37 necessary for microtubule-mediated capsid transport were sufficient for axonal capsid targeting in neurons derived from the dorsal root ganglia of adult mice. Such neurons were infected with HSV1-ΔUL20 whose capsids recruited pUL36 and pUL37, with HSV1-ΔUL37 whose capsids associate only with pUL36, or with HSV1-ΔUL36 that assembles capsids lacking both proteins. While capsids of HSV1-ΔUL20 were actively transported along microtubules in epithelial cells and in the somata of neurons, those of HSV1-ΔUL36 and -ΔUL37 could only diffuse in the cytoplasm. Employing a novel image analysis algorithm to quantify capsid targeting to axons, we show that only a few capsids of HSV1-ΔUL20 entered axons, while vesicles transporting gD utilized axonal transport efficiently and independently of pUL36, pUL37, or pUL20. Our data indicate that capsid motility in the somata of neurons mediated by pUL36 and pUL37 does not suffice for targeting capsids to axons, and suggest that capsid envelopment needs to be completed in the soma prior to targeting of herpes simplex virus to the axons, and to spreading from neurons to neighboring cells. PMID:29284065

78 FR 66651 - Imazapyr; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-06

... tolerances for imazapyr in or on grass, forage; grass, hay; fish; shellfish; fats of cattle, sheep, goats... requested from: Chief, Analytical Chemistry Branch, Environmental Science Center, 701 Mapes Rd., Ft. Meade...

Surgical excision for recurrent herpes simplex virus 2 (HSV-2) anogenital infection in a patient with human immunodeficiency virus (HIV).

PubMed

Arinze, Folasade; Shaver, Aaron; Raffanti, Stephen

2017-10-01

Recurrent anogenital herpes simplex virus infections are common in patients with human immunodeficiency virus (HIV), of whom approximately 5% develop resistance to acyclovir. We present a case of a 49-year-old man with HIV who had an 8-year history of recurrent left inguinal herpes simplex virus type 2 ulcerations. He initially responded to oral acyclovir, but developed resistance to acyclovir and eventually foscarnet. The lesion progressed to a large hypertrophic mass that required surgical excision, which led to resolution without recurrences. Our case highlights the importance of surgical excision as a treatment option in refractory herpes simplex virus anogenital infections.

Clinical and biological differences between recurrent herpes simplex virus and varicella-zoster virus infections

DOE Office of Scientific and Technical Information (OSTI.GOV)

Straus, S.E.

1989-12-01

The major features that distinguish recurrent herpes simplex virus infections from zoster are illustrated in this article by two case histories. The clinical and epidemiologic features that characterize recurrent herpes simplex virus and varicella-zoster virus infections are reviewed. It is noted that herpesvirus infections are more common and severe in patients with cellular immune deficiency. Each virus evokes both humoral and cellular immune response in the course of primary infection. DNA hybridization studies with RNA probes labelled with sulfur-35 indicate that herpes simplex viruses persist within neurons, and that varicella-zoster virus is found in the satellite cells that encircle themore » neurons.« less

A streamlined artificial variable free version of simplex method.

PubMed

Inayatullah, Syed; Touheed, Nasir; Imtiaz, Muhammad

2015-01-01

This paper proposes a streamlined form of simplex method which provides some great benefits over traditional simplex method. For instance, it does not need any kind of artificial variables or artificial constraints; it could start with any feasible or infeasible basis of an LP. This method follows the same pivoting sequence as of simplex phase 1 without showing any explicit description of artificial variables which also makes it space efficient. Later in this paper, a dual version of the new method has also been presented which provides a way to easily implement the phase 1 of traditional dual simplex method. For a problem having an initial basis which is both primal and dual infeasible, our methods provide full freedom to the user, that whether to start with primal artificial free version or dual artificial free version without making any reformulation to the LP structure. Last but not the least, it provides a teaching aid for the teachers who want to teach feasibility achievement as a separate topic before teaching optimality achievement.

A Streamlined Artificial Variable Free Version of Simplex Method

PubMed Central

Inayatullah, Syed; Touheed, Nasir; Imtiaz, Muhammad

2015-01-01

This paper proposes a streamlined form of simplex method which provides some great benefits over traditional simplex method. For instance, it does not need any kind of artificial variables or artificial constraints; it could start with any feasible or infeasible basis of an LP. This method follows the same pivoting sequence as of simplex phase 1 without showing any explicit description of artificial variables which also makes it space efficient. Later in this paper, a dual version of the new method has also been presented which provides a way to easily implement the phase 1 of traditional dual simplex method. For a problem having an initial basis which is both primal and dual infeasible, our methods provide full freedom to the user, that whether to start with primal artificial free version or dual artificial free version without making any reformulation to the LP structure. Last but not the least, it provides a teaching aid for the teachers who want to teach feasibility achievement as a separate topic before teaching optimality achievement. PMID:25767883

Oncolytic Herpes Simplex Viral Therapy: A Stride toward Selective Targeting of Cancer Cells.

PubMed

Sanchala, Dhaval S; Bhatt, Lokesh K; Prabhavalkar, Kedar S

2017-01-01

Oncolytic viral therapy, which makes use of replication-competent lytic viruses, has emerged as a promising modality to treat malignancies. It has shown meaningful outcomes in both solid tumor and hematologic malignancies. Advancements during the last decade, mainly genetic engineering of oncolytic viruses have resulted in improved specificity and efficacy of oncolytic viruses in cancer therapeutics. Oncolytic viral therapy for treating cancer with herpes simplex virus-1 has been of particular interest owing to its range of benefits like: (a) large genome and power to infiltrate in the tumor, (b) easy access to manipulation with the flexibility to insert multiple transgenes, (c) infecting majority of the malignant cell types with quick replication in the infected cells and (d) as Anti-HSV agent to terminate HSV replication. This review provides an exhaustive list of oncolytic herpes simplex virus-1 along with their genetic alterations. It also encompasses the major developments in oncolytic herpes simplex-1 viral therapy and outlines the limitations and drawbacks of oncolytic herpes simplex viral therapy.

Herpes simplex ulcerative esophagitis in healthy children.

PubMed

Al-Hussaini, Abdulrahman A; Fagih, Mosa A

2011-01-01

Herpes simplex virus is a common cause of ulcerative esophagitis in the immunocompromised or debilitated host. Despite a high prevalence of primary and recurrent Herpes simplex virus infection in the general population, Herpes simplex virus esophagitis (HSVE) appears to be rare in the immunocompetent host. We report three cases of endoscopically-diagnosed HSVE in apparently immunocompetent children; the presentation was characterized by acute onset of fever, odynophagia, and dysphagia. In two cases, the diagnosis was confirmed histologically by identification of herpes viral inclusions and culture of the virus in the presence of inflammation. The third case was considered to have probable HSVE based on the presence of typical cold sore on his lip, typical endoscopic finding, histopathological evidence of inflammation in esophageal biopsies and positive serologic evidence of acute Herpes simplex virus infection. Two cases received an intravenous course of acyclovir and one had self-limited recovery. All three cases had normal immunological workup and excellent health on long-term follow-up.

Testing the simplex assumption underlying the Sport Motivation Scale: a structural equation modeling analysis.

PubMed

Li, F; Harmer, P

1996-12-01

Self-determination theory (Deci & Ryan, 1985) suggests that motivational orientation or regulatory styles with respect to various behaviors can be conceptualized along a continuum ranging from low (a motivation) to high (intrinsic motivation) levels of self-determination. This pattern is manifested in the rank order of correlations among these regulatory styles (i.e., adjacent correlations are expected to be higher than those more distant) and is known as a simplex structure. Using responses from the Sport Motivation Scale (Pelletier et al., 1995) obtained from a sample of 857 college students (442 men, 415 women), the present study tested the simplex structure underlying SMS subscales via structural equation modeling. Results confirmed the simplex model structure, indicating that the various motivational constructs are empirically organized from low to high self-determination. The simplex pattern was further found to be invariant across gender. Findings from this study support the construct validity of the SMS and have important implications for studies focusing on the influence of motivational orientation in sport.

Visiting EPA Region 3’s Offices

EPA Pesticide Factsheets

Information on visiting EPA Region 3’s offices in Philadelphia, Pa., Annapolis, Md., Fort Meade, Md. and Wheeling, W. Va. including the address, building access, public transportation and driving directions.

43 CFR 431.4 - Power generation responsibilities.

Code of Federal Regulations, 2014 CFR

2014-10-01

... facilities and equipment at the Hoover Powerplant, are the responsibilities of Reclamation. (b) Subject to the statutory requirement that Hoover Dam and Lake Mead shall be used: First, for river regulation...

43 CFR 431.4 - Power generation responsibilities.

Code of Federal Regulations, 2012 CFR

2012-10-01

... facilities and equipment at the Hoover Powerplant, are the responsibilities of Reclamation. (b) Subject to the statutory requirement that Hoover Dam and Lake Mead shall be used: First, for river regulation...

43 CFR 431.4 - Power generation responsibilities.

Code of Federal Regulations, 2013 CFR

2013-10-01

... facilities and equipment at the Hoover Powerplant, are the responsibilities of Reclamation. (b) Subject to the statutory requirement that Hoover Dam and Lake Mead shall be used: First, for river regulation...

43 CFR 431.4 - Power generation responsibilities.

Code of Federal Regulations, 2011 CFR

2011-10-01

... facilities and equipment at the Hoover Powerplant, are the responsibilities of Reclamation. (b) Subject to the statutory requirement that Hoover Dam and Lake Mead shall be used: First, for river regulation...

43 CFR 431.4 - Power generation responsibilities.

Code of Federal Regulations, 2010 CFR

2010-10-01

... facilities and equipment at the Hoover Powerplant, are the responsibilities of Reclamation. (b) Subject to the statutory requirement that Hoover Dam and Lake Mead shall be used: First, for river regulation...

Dendritic cells in the cornea during Herpes simplex viral infection and inflammation.

PubMed

Kwon, Min S; Carnt, Nicole A; Truong, Naomi R; Pattamatta, Ushasree; White, Andrew J; Samarawickrama, Chameen; Cunningham, Anthony L

Herpes simplex keratitis is commonly caused by Herpes simplex virus type 1, which primarily infects eyelids, corneas, or conjunctiva. Herpes simplex virus type 1-through sophisticated interactions with dendritic cells (DCs), a type of antigen-presenting cell)-initiates proinflammatory responses in the cornea. Corneas were once thought to be an immune-privileged region; however, with the recent discovery of DCs that reside in the cornea, this long-held conjecture has been overturned. Therefore, evaluating the clinical, preclinical, and cell-based studies that investigate the roles of DCs in corneas infected with Herpes simplex virus is critical. With in vivo confocal microscopy, animal models, and cell culture experiments, we may further the understanding of the sophisticated interactions of Herpes simplex virus with DCs in the cornea and the molecular mechanism associated with it. It has been shown that specific differentiation of DCs using immunohistochemistry, flow cytometry, and polymerase chain reaction analysis in both human and mice tissues and viral tissue infections are integral to increasing understanding. As for in vivo confocal microscopy, it holds promise as it is the least invasive and a real-time investigation. These tools will facilitate the discovery of various targets to develop new treatments. Copyright © 2017 Elsevier Inc. All rights reserved.

Laboratory diagnosis and epidemiology of herpes simplex 1 and 2 genital infections.

PubMed

Glinšek Biškup, Urška; Uršič, Tina; Petrovec, Miroslav

2015-01-01

Herpes simplex virus types 1 and 2 are the main cause of genital ulcers worldwide. Although herpes simplex virus type 2 is the major cause of genital lesions, herpes simplex virus type 1 accounts for half of new cases in developed countries. Herpes simplex virus type 2 seroprevalence rises with sexual activity from adolescence through adulthood. Slovenian data in a high-risk population shows 16% seroprevalence of HSV-2. HSV-1 and HSV-2 DNA in genital swabs was detected in 19% and 20.7%, respectively. In most cases, genital herpes is asymptomatic. Primary genital infection with herpes simplex virus types 1 and 2 can be manifested by a severe clinical picture, involving the vesicular skin and mucosal changes and ulcerative lesions of the vulva, vagina, and cervix in women and in the genital region in men. Direct methods of viral genome detection are recommended in the acute stage of primary and recurrent infections when manifest ulcers or lesions are evident. Serological testing is recommended as an aid in diagnosing genital herpes in patients with reinfection in atypical or already healed lesions. When herpes lesions are present, all sexual activities should be avoided to prevent transmission of infection. Antiviral drugs can reduce viral shedding and thus reduce the risk of sexual transmission of the virus.

Petrographic Descriptions of Selected Rock Specimens From the Meade Peak Phosphatic Shale Member, Phosphoria Formation (Permian), Southeastern Idaho

USGS Publications Warehouse

Johnson, Edward A.; Grauch, Richard I.; Herring, James R.

2007-01-01

Based on petrographic observations of 135 thin sections, rocks in the Meade Peak Phosphatic Shale Member of the Permian Phosphoria Formation in southeastern Idaho can be placed into one of four major lithofacies: organic claystone, muddy siltstone, peloidal phosphorite, and dolomitized calclithite-in order of decreasing abundance. Organic claystones are the most common lithofacies in the Meade Peak. Many of these rocks contain sufficient amounts of silt to make silty, organic claystones a common subtype. Organic claystones commonly contain crystals of muscovite and bioclasts as accessory components, and they are typically parallel laminated. Muddy siltstones are composed primarily of quartz silt, but some feldspar and rare carbonate silt are also present; some rocks are parallel laminated. Phosphate peloids are composed of varying amounts of opaque, complex, and translucent material, and observed internal structures are classified as simple, banded, cored, zoned, oolitic, nucleated, and polynucleated. Opaque, complex, and translucent peloids form the framework grains of three peloidal phosphorite rocks: wackestone phosphorite, packstone phosphorite, and grainstone phosphorite. Wackestone phosphorite is phosphatic-mud supported and contains more than 10 percent peloids; it is the most common type of phosphorite. Packstone phosphorite is peloid supported and contains interstitial phosphatic mud; it is also a common type. Grainstone phosphorite is peloid supported but lacks phosphatic mud; it is the least common type. Dolomitized calclithites contain three types of carbonate grains: macrocrystalline, microcrystalline, and crystalline with a microcrystalline nuclei-in order of decreasing abundance. Based on chemical staining and X-ray diffraction analyses, most of the carbonate is dolomite. Sufficient amounts of quartz silt or muddy material allow some rocks to be called silty dolomitized calclithite or muddy dolomitized calclithite, respectively. Sedimentary structures are absent except in some muddy dolomitized calclithites. Organic claystones, muddy siltstones, and dolomitized calclithites are detrital deposits. Many rocks in the Meade Peak contain calcite and apatite as fracture fillings and vug linings. As expected, peloidal phosphorites are most common in ore zones, and detrital rocks are most common in waste zones. Mine-specific marker beds are mostly composed of dolomitized calclithite.

[A case of an allergic reaction due to Anisakis simplex possibly after the ingestion of squid--successful detection of four A. simplex allergens, Ani s 1, Ani s 2, Ani s 12 and troponin C-like protein].

PubMed

Iijima, Shigeruko; Moriyama, Tatsuya; Ichikawa, Hidetaka; Kobayashi, Yukihiro; Shiomi, Kazuo

2012-08-01

A 62-year-old man ingested dressed salmon and its roe (ikura) and grilled mackerel and one hour later further ingested raw tuna and squid as an evening meal at a bar. Soon after the ingestion of raw seafood, he showed wheals, loss of consciousness and low blood pressure. Specific serum IgE to the nematode Anisakis simplex was positive but those to some seafoods were negative. Moreover, a skin prick test using the crude extract was positive for A. simplex but negative for the seafoods, which he ingested on the day of the above episode. When the A. simplex extract was analyzed by IgE-binding immunoblot analysis using the patient serum, two highly intense protein bands were recognized at 18 and 17 kDa, one intense band at 35 kDa and two weak bands at 28 and 26 kDa. ELISA with 11 natural or recombinant A. simplex allergens (Ani s 1-6, 8, 9, 11 and 12 and troponin C-like protein) showed that the patient serum strongly reacted to Ani s 1 and Ani s 12 and weakly to Ani s 2 and troponin C-like protein. Based on these results, he was diagnosed as IgE-mediated A. simplex allergy due to four allergens (Ani s 1, Ani s 2, Ani s 12 and troponin C-like protein), possibly infested in the raw squid which he had ingested just before manifestation of allergic reactions.

Allergy and parasites reevaluated: wide-scale induction of chronic urticaria by the ubiquitous fish-nematode Anisakis simplex in an endemic region.

PubMed

Daschner, A; Vega de la Osada, F; Pascual, C Y

2005-01-01

The ubiquitous fish-nematode Anisakis simplex produces acute urticaria or angioedema in the course of gastro-allergic anisakiasis. We studied the relationship between this nematode and chronic urticaria (CU), as well as the clinical usefulness of measuring specific IgG4 in A. simplex-sensitized patients with CU. First, the prevalence of sensitization to A. simplex was estimated in 135 consecutive CU patients and the result was compared with known data about sensitization in a healthy population. Then, clinical response to a 2-month diet without fish was analyzed in 76 CU patients. The improvement rate in patients with and without sensitization to A. simplex was compared. Finally, the improvement rate, other clinical data and specific immunoglobulins in sensitized patients with and without detectable specific IgG4 were compared. a) The A. simplex sensitization rate in CU patients was 52.6 % compared with a known prevalence of between 16 and 20 % in our region. b) Of 65 sensitized patients, 52 experienced clinical improvement after the diet compared with only three of 11 patients without sensitization to A. simplex (p = 0.001). c) Of 43 patients with detectable specific IgG4, 38 showed clinical improvement compared with only 14 of 22 patients without detectable IgG4 (p = 0.02). Eight of nine patients with previous fish-associated cutaneous symptoms had detectable specific IgG4 compared with 15 of 32 patients who reported no previous fish-associated symptoms or acute urticaria (p = 0.03). Our results indicate that A. simplex is a possibly widespread etiologic agent able to induce CU. This parasite model constitutes the first report that associates an infectious agent with CU on a large scale. The detection of IgG4 antibodies reflects a previous acute parasitic infection and a temporary diet without fish improves symptoms in most patients with detectable specific IgG4.

A fast fully constrained geometric unmixing of hyperspectral images

NASA Astrophysics Data System (ADS)

Zhou, Xin; Li, Xiao-run; Cui, Jian-tao; Zhao, Liao-ying; Zheng, Jun-peng

2014-11-01

A great challenge in hyperspectral image analysis is decomposing a mixed pixel into a collection of endmembers and their corresponding abundance fractions. This paper presents an improved implementation of Barycentric Coordinate approach to unmix hyperspectral images, integrating with the Most-Negative Remove Projection method to meet the abundance sum-to-one constraint (ASC) and abundance non-negativity constraint (ANC). The original barycentric coordinate approach interprets the endmember unmixing problem as a simplex volume ratio problem, which is solved by calculate the determinants of two augmented matrix. One consists of all the members and the other consist of the to-be-unmixed pixel and all the endmembers except for the one corresponding to the specific abundance that is to be estimated. In this paper, we first modified the algorithm of Barycentric Coordinate approach by bringing in the Matrix Determinant Lemma to simplify the unmixing process, which makes the calculation only contains linear matrix and vector operations. So, the matrix determinant calculation of every pixel, as the original algorithm did, is avoided. By the end of this step, the estimated abundance meet the ASC constraint. Then, the Most-Negative Remove Projection method is used to make the abundance fractions meet the full constraints. This algorithm is demonstrated both on synthetic and real images. The resulting algorithm yields the abundance maps that are similar to those obtained by FCLS, while the runtime is outperformed as its computational simplicity.

Recourse-based facility-location problems in hybrid uncertain environment.

PubMed

Wang, Shuming; Watada, Junzo; Pedrycz, Witold

2010-08-01

The objective of this paper is to study facility-location problems in the presence of a hybrid uncertain environment involving both randomness and fuzziness. A two-stage fuzzy-random facility-location model with recourse (FR-FLMR) is developed in which both the demands and costs are assumed to be fuzzy-random variables. The bounds of the optimal objective value of the two-stage FR-FLMR are derived. As, in general, the fuzzy-random parameters of the FR-FLMR can be regarded as continuous fuzzy-random variables with an infinite number of realizations, the computation of the recourse requires solving infinite second-stage programming problems. Owing to this requirement, the recourse function cannot be determined analytically, and, hence, the model cannot benefit from the use of techniques of classical mathematical programming. In order to solve the location problems of this nature, we first develop a technique of fuzzy-random simulation to compute the recourse function. The convergence of such simulation scenarios is discussed. In the sequel, we propose a hybrid mutation-based binary ant-colony optimization (MBACO) approach to the two-stage FR-FLMR, which comprises the fuzzy-random simulation and the simplex algorithm. A numerical experiment illustrates the application of the hybrid MBACO algorithm. The comparison shows that the hybrid MBACO finds better solutions than the one using other discrete metaheuristic algorithms, such as binary particle-swarm optimization, genetic algorithm, and tabu search.

75 FR 14159 - Notice of Agreements Filed

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-24

... Americana de Vapores and Kawasaki Kisen Kaisha, Ltd. Filing Parties: John P. Meade, Esq.; Vice-President; K... Attorney; 1850 Eller Drive, Suite 502; Fort Lauderdale, FL 33316. Synopsis: The amendment updates various...

Computational Efficiency of the Simplex Embedding Method in Convex Nondifferentiable Optimization

NASA Astrophysics Data System (ADS)

Kolosnitsyn, A. V.

2018-02-01

The simplex embedding method for solving convex nondifferentiable optimization problems is considered. A description of modifications of this method based on a shift of the cutting plane intended for cutting off the maximum number of simplex vertices is given. These modification speed up the problem solution. A numerical comparison of the efficiency of the proposed modifications based on the numerical solution of benchmark convex nondifferentiable optimization problems is presented.

Trivial dynamics in discrete-time systems: carrying simplex and translation arcs

NASA Astrophysics Data System (ADS)

Niu, Lei; Ruiz-Herrera, Alfonso

2018-06-01

In this paper we show that the dynamical behavior in (first octant) of the classical Kolmogorov systems of competitive type admitting a carrying simplex can be sometimes determined completely by the number of fixed points on the boundary and the local behavior around them. Roughly speaking, T has trivial dynamics (i.e. the omega limit set of any orbit is a connected set contained in the set of fixed points) provided T has exactly four hyperbolic nontrivial fixed points in with local attractors on the carrying simplex and local repellers on the carrying simplex; and there exists a unique hyperbolic fixed point in Int. Our results are applied to some classical models including the Leslie–Gower models, Atkinson-Allen systems and Ricker maps.

Prediction and identification of potential immunodominant epitopes in glycoproteins B, C, E, G, and I of herpes simplex virus type 2.

PubMed

Pan, Mingjie; Wang, Xingsheng; Liao, Jianmin; Yin, Dengke; Li, Suqin; Pan, Ying; Wang, Yao; Xie, Guangyan; Zhang, Shumin; Li, Yuexi

2012-01-01

Twenty B candidate epitopes of glycoproteins B (gB2), C (gC2), E (gE2), G (gG2), and I (gI2) of herpes simplex virus type 2 (HSV-2) were predicted using DNAstar, Biosun, and Antheprot methods combined with the polynomial method. Subsequently, the biological functions of the peptides were tested via experiments in vitro. Among the 20 epitope peptides, 17 could react with the antisera to the corresponding parent proteins in the EIA tests. In particular, five peptides, namely, gB2(466-473) (EQDRKPRN), gC2(216-223) (GRTDRPSA), gE2(483-491) (DPPERPDSP), gG2(572-579) (EPPDDDDS), and gI2(286-295) (CRRRYRRPRG) had strong reaction with the antisera. All conjugates of the five peptides with the carrier protein BSA could stimulate mice into producing antibodies. The antisera to these peptides reacted strongly with the corresponding parent glycoproteins during the Western Blot tests, and the peptides reacted strongly with the antibodies against the parent glycoproteins during the EIA tests. The antisera against the five peptides could neutralize HSV-2 infection in vitro, which has not been reported until now. These results suggest that the immunodominant epitopes screened using software algorithms may be used for virus diagnosis and vaccine design against HSV-2.

Augmented design and analysis of computer experiments: a novel tolerance embedded global optimization approach applied to SWIR hyperspectral illumination design.

PubMed

Keresztes, Janos C; John Koshel, R; D'huys, Karlien; De Ketelaere, Bart; Audenaert, Jan; Goos, Peter; Saeys, Wouter

2016-12-26

A novel meta-heuristic approach for minimizing nonlinear constrained problems is proposed, which offers tolerance information during the search for the global optimum. The method is based on the concept of design and analysis of computer experiments combined with a novel two phase design augmentation (DACEDA), which models the entire merit space using a Gaussian process, with iteratively increased resolution around the optimum. The algorithm is introduced through a series of cases studies with increasing complexity for optimizing uniformity of a short-wave infrared (SWIR) hyperspectral imaging (HSI) illumination system (IS). The method is first demonstrated for a two-dimensional problem consisting of the positioning of analytical isotropic point sources. The method is further applied to two-dimensional (2D) and five-dimensional (5D) SWIR HSI IS versions using close- and far-field measured source models applied within the non-sequential ray-tracing software FRED, including inherent stochastic noise. The proposed method is compared to other heuristic approaches such as simplex and simulated annealing (SA). It is shown that DACEDA converges towards a minimum with 1 % improvement compared to simplex and SA, and more importantly requiring only half the number of simulations. Finally, a concurrent tolerance analysis is done within DACEDA for to the five-dimensional case such that further simulations are not required.

13. Interior view of open; showing exterior window, open doorways ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. Interior view of open; showing exterior window, open doorways into offices; northeast corner of building; view to southeast. - Ellsworth Air Force Base, Warehouse, 789 Twining Street, Blackhawk, Meade County, SD

PDG Construction, LLC Information Sheet

EPA Pesticide Factsheets

PDG Construction, LLC d/b/a Princeton Design Guild (the Company) is located in Bell Meade, New Jersey. The settlement involves renovation activities conducted at property constructed prior to 1978, located in Hopewell, New Jersey.

43 CFR 3206.11 - What must BLM do before issuing a lease?

Code of Federal Regulations, 2013 CFR

2013-10-01

... OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) GEOTHERMAL RESOURCE LEASING... National Park; (14) Hawaii Volcanoes National Park; (15) Haleakala National Park; (16) Lake Mead National...

43 CFR 3206.11 - What must BLM do before issuing a lease?

Code of Federal Regulations, 2012 CFR

2012-10-01

... OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) GEOTHERMAL RESOURCE LEASING... National Park; (14) Hawaii Volcanoes National Park; (15) Haleakala National Park; (16) Lake Mead National...

43 CFR 3206.11 - What must BLM do before issuing a lease?

Code of Federal Regulations, 2014 CFR

2014-10-01

... OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) GEOTHERMAL RESOURCE LEASING... National Park; (14) Hawaii Volcanoes National Park; (15) Haleakala National Park; (16) Lake Mead National...

Comparison and analysis of empirical equations for soil heat flux for different cropping systems and irrigation methods

USGS Publications Warehouse

Irmak, A.; Singh, Ramesh K.; Walter-Shea, Elizabeth; Verma, S.B.; Suyker, A.E.

2011-01-01

We evaluated the performance of four models for estimating soil heat flux density (G) in maize (Zea mays L.) and soybean (Glycine max L.) fields under different irrigation methods (center-pivot irrigated fields at Mead, Nebraska, and subsurface drip irrigated field at Clay Center, Nebraska) and rainfed conditions at Mead. The model estimates were compared against measurements made during growing seasons of 2003, 2004, and 2005 at Mead and during 2005, 2006, and 2007 at Clay Center. We observed a strong relationship between the G and net radiation (Rn) ratio (G/Rn) and the normalized difference vegetation index (NDVI). When a significant portion of the ground was bare soil, G/Rn ranged from 0.15 to 0.30 and decreased with increasing NDVI. In contrast to the NDVI progression, the G/Rn ratio decreased with crop growth and development. The G/Rn ratio for subsurface drip irrigated crops was smaller than for the center-pivot irrigated crops. The seasonal average G was 13.1%, 15.2%, 10.9%, and 12.8% of Rn for irrigated maize, rainfed maize, irrigated soybean, and rainfed soybean, respectively. Statistical analyses of the performance of the four models showed a wide range of variation in G estimation. The root mean square error (RMSE) of predictions ranged from 15 to 81.3 W m-2. Based on the wide range of RMSE, it is recommended that local calibration of the models should be carried out for remote estimation of soil heat flux.

Harry Stack Sullivan Colloquium: George Herbert Mead and Harry Stack Sullivan: an unfinished synthesis.

PubMed

Cottrell, L S

1978-05-01

HOW DO YOU create a new self? However he may phrase this question, it is a central theoretical and practical concern of the therapist every time he confronts a client who comes to him for help. What are the processes out of which the human self emerges? However he may phrase the question, it is a central concern of the social psychologist. The obvious convergence of interests indicated by these two questions should occasion no surprise among students of Sullivan and Mead. What perhaps should be surprising is that an effective synthesis of their theories has progressed no further than it has to date. My remarks today are based on the conviction that a more adequate psychiatric theory and practice and a more complete social psychological theory and research program depend on such a synthesis. Behavioral scientists concerned with the development of a truly interactionist social psychology are, I believe, generally agreed that George Herbert Mead (1863-1931), philosopher and social psychologist, and Harry Stack Sullivan (1892-1949), psychiatrist and social psychologist, have laid conceptual foundations upon which such a discipline can be erected. Now a vast assortment of activities is tagged as social psychology and its boundaries are, indeed, difficult to draw. However, for our present purposes we can define its focus as the study of the processes and products of inter- and intrapersonal and inter- and intragoup interaction, let the boundaries fall where they will.

Geologic map of Lake Mead and surrounding regions, southern Nevada, southwestern Utah, and northwestern Arizona

USGS Publications Warehouse

Felger, Tracey J.; Beard, Sue

2010-01-01

Regional stratigraphic units and structural features of the Lake Mead region are presented as a 1:250,000 scale map, and as a Geographic Information System database. The map, which was compiled from existing geologic maps of various scales, depicts geologic units, bedding and foliation attitudes, faults and folds. Units and structural features were generalized to highlight the regional stratigraphic and tectonic aspects of the geology of the Lake Mead region. This map was prepared in support of the papers presented in this volume, Special Paper 463, as well as to facilitate future investigations in the region. Stratigraphic units exposed within the area record 1800 million years of geologic history and include Proterozoic crystalline rocks, Paleozoic and Mesozoic sedimentary rocks, Mesozoic plutonic rocks, Cenozoic volcanic and intrusive rocks, sedimentary rocks and surfi cial deposits. Following passive margin sedimentation in the Paleozoic and Mesozoic, late Mesozoic (Sevier) thrusting and Late Cretaceous and early Tertiary compression produced major folding, reverse faulting, and thrust faulting in the Basin and Range, and resulted in regional uplift and monoclinal folding in the Colorado Plateau. Cenozoic extensional deformation, accompanied by sedimentation and volcanism, resulted in large-magnitude high- and low-angle normal faulting and strike-slip faulting in the Basin and Range; on the Colorado Plateau, extension produced north-trending high-angle normal faults. The latest history includes integration of the Colorado River system, dissection, development of alluvial fans, extensive pediment surfaces, and young faulting.

Herpes simplex type 1 pneumonitis and acute respiratory distress syndrome in a patient with chronic lymphatic leukemia: a case report.

PubMed

Luginbuehl, Miriam; Imhof, Alexander; Klarer, Alexander

2017-11-23

Pulmonary pathogenicity of herpes simplex virus type 1 in patients in intensive care without classic immunosuppression as well as the necessity of antiviral treatment in the case of herpes simplex virus detection in respiratory specimens in these patients is controversial. We present a case of acute respiratory distress syndrome in a patient with stable chronic lymphatic leukemia not requiring treatment, in whom we diagnosed herpes simplex virus type 1 bronchopneumonitis based on herpes simplex virus type 1 detection in bronchoalveolar lavage fluid and clinical response to antiviral treatment. A 72-year-old white man presented with symptoms of lower respiratory tract infection. His medical history was significant for chronic lymphatic leukemia, which had been stable without treatment, arterial hypertension, multiple squamous cell carcinomas of the scalp, and alcohol overuse. Community-acquired pneumonia was suspected and appropriate broad-spectrum antibacterial treatment was initiated. Within a few hours, rapid respiratory deterioration led to cardiac arrest. He was successfully resuscitated, but developed acute respiratory distress syndrome. Furthermore, he remained febrile and inflammation markers remained elevated despite antibacterial treatment. Polymerase chain reaction from bronchoalveolar lavage fluid and viral culture from tracheobronchial secretions tested positive for herpes simplex virus type 1. We initiated antiviral treatment with acyclovir. Concomitantly we further escalated the antibacterial treatment, although no bacterial pathogen had been isolated at any point. Defervescence occurred rapidly and his C-reactive protein and leukocyte levels decreased. He was successfully weaned from mechanical ventilation, transferred to the ward, and eventually discharged to home. Herpes simplex virus should be considered a cause for lower respiratory tract infection in critically ill patients, especially in the setting of an underlying disease.

Laryngopharyngeal reflux and herpes simplex virus type 2 are possible risk factors for adult-onset recurrent respiratory papillomatosis (prospective case-control study).

PubMed

Formánek, M; Jančatová, D; Komínek, P; Matoušek, P; Zeleník, K

2017-06-01

The human papillomavirus (HPV) causes recurrent respiratory papillomatosis (RRP). Although HPV prevalence is high, the incidence of papillomatosis is low. Thus, factors other than HPV infection probably contribute to RRP. This study investigated whether patients with papillomatosis are more often infected with herpes simplex virus type 2 and chlamydia trachomatis (ChT) and whether laryngopharyngeal reflux (LPR) occurs in this group of patients more often. Prospective case-control study. Department of Otorhinolaryngology of University Hospital. The study included 20 patients with adult-onset RRP and 20 adult patients with vocal cord cyst and no pathology of laryngeal mucosa (control group). Immunohistochemical analysis of pepsin, HPV, herpes simplex virus type 2 and ChT was performed in biopsy specimens of laryngeal papillomas and of healthy laryngeal mucosa (control group) obtained from medial part of removed vocal cord cyst during microlaryngoscopy procedures. Pathologic LPR (pepsin in tissue) was diagnosed in 8/20 (40.0%) patients with papillomatosis and in 0/20 control patients (P = .003). Herpes simplex virus type 2 was present in 9/20 (45.0%) patients with papillomatosis and in 0/20 control patients (P = .001). Five specimens were positive for both pepsin and herpes simplex virus type 2. No samples were positive for ChT. There were no significant differences between groups for age, body mass index, diabetes mellitus and gastrooesophageal reflux disease. Tobacco exposure was not more frequent in RRP group either (P = .01). Results show that LPR and herpes simplex virus type 2 are significantly more often present in patients with RRP. LPR and herpes simplex virus type 2 might activate latent HPV infection and thereby be possible risk factors for RRP. © 2016 John Wiley & Sons Ltd.

Simplex-based optimization of numerical and categorical inputs in early bioprocess development: Case studies in HT chromatography.

PubMed

Konstantinidis, Spyridon; Titchener-Hooker, Nigel; Velayudhan, Ajoy

2017-08-01

Bioprocess development studies often involve the investigation of numerical and categorical inputs via the adoption of Design of Experiments (DoE) techniques. An attractive alternative is the deployment of a grid compatible Simplex variant which has been shown to yield optima rapidly and consistently. In this work, the method is combined with dummy variables and it is deployed in three case studies wherein spaces are comprised of both categorical and numerical inputs, a situation intractable by traditional Simplex methods. The first study employs in silico data and lays out the dummy variable methodology. The latter two employ experimental data from chromatography based studies performed with the filter-plate and miniature column High Throughput (HT) techniques. The solute of interest in the former case study was a monoclonal antibody whereas the latter dealt with the separation of a binary system of model proteins. The implemented approach prevented the stranding of the Simplex method at local optima, due to the arbitrary handling of the categorical inputs, and allowed for the concurrent optimization of numerical and categorical, multilevel and/or dichotomous, inputs. The deployment of the Simplex method, combined with dummy variables, was therefore entirely successful in identifying and characterizing global optima in all three case studies. The Simplex-based method was further shown to be of equivalent efficiency to a DoE-based approach, represented here by D-Optimal designs. Such an approach failed, however, to both capture trends and identify optima, and led to poor operating conditions. It is suggested that the Simplex-variant is suited to development activities involving numerical and categorical inputs in early bioprocess development. © 2017 The Authors. Biotechnology Journal published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Herpes simplex virus type 2: Cluster of unrelated cases in an intensive care unit.

PubMed

Troché, Gilles; Marque Juillet, Stephanie; Burrel, Sonia; Boutolleau, David; Bédos, Jean-Pierre; Legriel, Stephane

2016-10-01

Herpes simplex viruses, which are associated with various clinical manifestations, can be transmitted to critically ill patients from other patients or health care staff. We report an apparent outbreak of mucocutaneous herpes simplex virus 2 infections (5 cases in 10 weeks). An epidemiologic investigation and genotype analysis showed no connections among the 5 cases. Copyright © 2016 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

Medical Surveillance Monthly Report (MSMR). Volume 20, Number 2, February 2013

DTIC Science & Technology

2013-02-01

have viral etiologies: infections with human papillomavirus (HPV) and genital herpes simplex virus (HSV). Sexually transmitted infections have...infertility No Genital herpes simplex virus (HSV) 3 Virus No Yes Genital sores, infection of newborn babies No Acute gonorrhea 4 Bacterium Yes . PID...796.79 Chlamydia 099.41, 099.5 Genital herpes simplex virus (HSV) 054.1 Acute gonorrhea 098.0x, 098.1x, 098.4x, 098.8x Syphilis, all types All of those

Comparison of a new bisphenol-a-glycidyl dimethacrylate-based cortical bone void filler with polymethyl methacrylate.

PubMed

Erbe, E M; Clineff, T D; Gualtieri, G

2001-10-01

A newly formulated and reinforced bisphenol-a-glycidyl dimethacrylate (bis-GMA) resin (Cortoss/Orthovita, Malvern, Pa.) was compared with Simplex P polymethyl methacrylate (Stryker Howmedica Osteonics, East Rutherford, N.J.) in rabbits for up to 52 weeks and in sheep for up to 78 weeks. As seen in scanning electron microscopy and histology examinations, both implant materials were surrounded by bone at late time periods, with fibrous layers of connective tissue seen in half the Simplex P specimens. No clinically significant safety differences between implant materials were apparent. Interfacial bond strengths between the implant and bone generally increased with time, but were 4.5-fold greater with Cortoss than Simplex P at 24 weeks, and 100-fold greater at 52 weeks. Forces required to displace 316SS rods held in place with Cortoss were consistently greater than forces to displace rods held in place with Simplex P. No statistically significant differences in displacement forces were found between rods held in place with Cortoss polymerized in situ and rods held with prepolymerized Cortoss. Interfacial bond strengths were greater for Simplex P that was polymerized in situ than for prepolymerized polymethyl methacrylate specimens. Cortoss synthetic cortical bone void filler is a good candidate material to fix implants in bone. It has characteristics consistent with long-term safety and has a better ability to bond to bone than Simplex P.

Genital herpes simplex virus infections.

PubMed

Rosenthal, M S

1979-09-01

In recent years, a great increase in interest in genital herpes has been stimulated partly by the rising prevalence of this disease and partly by observations suggesting that genital herpes is a cause of cervical cancer. The clinical pictures produced by genital herpes simplex virus infections are similar in men and women. In contrast to recurrent attacks, initial episodes of infection are generally more extensive, last longer, and are more often associated with regional lymphadenopathy and systemic symptoms. Genital herpes in pregnancy may pose a serious threat to the newborn infant. Although the data suggesting genital herpes simplex virus infection is a cause of cervical cancer are quite extensive, the evidence is largely circumstantial. In spite of these more serious aspects of genital herpes simplex virus infection, episodes of genital herpes are almost always self-limited and benign. Frequent recurrences pose the major therapeutic and management problem. At present, there is no satisfactory treatment for recurrent genital herpes simplex virus in fection. Many of the suggested therapies, although some sound very promising, are potentially dangerous and should be used only under carefully controlled conditions.

5 CFR 1312.29 - Destruction.

Code of Federal Regulations, 2010 CFR

2010-01-01

.... Classified official record material will be processed to the Information Systems and Technology, Records.../CSS Directorate for Information Systems Security, Ft. Meade, Maryland 20755. Specifications concerning..., DECLASSIFICATION AND SAFEGUARDING OF NATIONAL SECURITY INFORMATION Control and Accountability of Classified...

Special type culvert headwall, Culvert No. 124 Outlet, oblique view, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Special type culvert headwall, Culvert No. 124 Outlet, oblique view, view to southwest - Route No. 1-Overton-Lake Mead Road, Culverts and Headwalls, 6 miles south of Overton, Overton, Clark County, NV

Special type culvert headwall, Culvert No. 109 Outlet, oblique view, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Special type culvert headwall, Culvert No. 109 Outlet, oblique view, view to southeast - Route No. 1-Overton-Lake Mead Road, Culverts and Headwalls, 6 miles south of Overton, Overton, Clark County, NV

Straight type culvert headwall, Culvert No. 105 Inlet, oblique view, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Straight type culvert headwall, Culvert No. 105 Inlet, oblique view, view to northeast - Route No. 1-Overton-Lake Mead Road, Culverts and Headwalls, 6 miles south of Overton, Overton, Clark County, NV

6. Interior, rear offices: operations assistant office looking north toward ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. Interior, rear offices: operations assistant office looking north toward security operations officer's office. - Ellsworth Air Force Base, Rushmore Air Force Station, Security Central Control Building, Quesada Drive, Blackhawk, Meade County, SD

Effect of Prior Immunization on Induction of Cervical Cancer in Mice by Herpes Simplex Virus Type 2

NASA Astrophysics Data System (ADS)

Budd Wentz, W.; Heggie, Alfred D.; Anthony, Donald D.; Reagan, James W.

1983-12-01

Previous studies at this laboratory showed that repeated application of inactivated herpes simplex virus type 2 to the mouse cervix produces premalignant and malignant lesions. In the present study mice were inoculated with inactivated herpes simplex virus type 2 or control solution and Freund's adjuvant by intraperitoneal and subcutaneous routes before exposure of the cervix to inactivated virus. It appears that immunization with inactivated virus conferred a protection against the induction of cervical carcinoma.

Intelligent design optimization of a shape-memory-alloy-actuated reconfigurable wing

NASA Astrophysics Data System (ADS)

Lagoudas, Dimitris C.; Strelec, Justin K.; Yen, John; Khan, Mohammad A.

2000-06-01

The unique thermal and mechanical properties offered by shape memory alloys (SMAs) present exciting possibilities in the field of aerospace engineering. When properly trained, SMA wires act as linear actuators by contracting when heated and returning to their original shape when cooled. It has been shown experimentally that the overall shape of an airfoil can be altered by activating several attached SMA wire actuators. This shape-change can effectively increase the efficiency of a wing in flight at several different flow regimes. To determine the necessary placement of these wire actuators within the wing, an optimization method that incorporates a fully-coupled structural, thermal, and aerodynamic analysis has been utilized. Due to the complexity of the fully-coupled analysis, intelligent optimization methods such as genetic algorithms have been used to efficiently converge to an optimal solution. The genetic algorithm used in this case is a hybrid version with global search and optimization capabilities augmented by the simplex method as a local search technique. For the reconfigurable wing, each chromosome represents a realizable airfoil configuration and its genes are the SMA actuators, described by their location and maximum transformation strain. The genetic algorithm has been used to optimize this design problem to maximize the lift-to-drag ratio for a reconfigured airfoil shape.

13. Interior view of food storage area looking towards hallway; ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. Interior view of food storage area looking towards hallway; southeast corner of building on lower floor; view to north. - Ellsworth Air Force Base, Mess & Administration Building, 1561 Ellsworth Street, Blackhawk, Meade County, SD

17. Interior view of vestibule separating locker rooms, changing rooms ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

17. Interior view of vestibule separating locker rooms, changing rooms and restroom beyond; southwest corner of unoccupied portion; view to northwest. - Ellsworth Air Force Base, Mess & Administration Building, 2279 Risner Drive, Blackhawk, Meade County, SD

Marketing Electronic Information.

ERIC Educational Resources Information Center

Davenport, Lizzie; Cronin, Blaise

1987-01-01

The history of DIALOG, Mead Data Central, and other vendors of online business databases is surveyed to illustrate their use of classic business strategy by balancing consolidation of assets and differentiation of products. A discussion of pricing strategies is also included. (EM)

Universal mechanisms of sound production and control in birds and mammals

PubMed Central

Elemans, C.P.H; Rasmussen, J.H.; Herbst, C.T.; Düring, D.N.; Zollinger, S.A.; Brumm, H.; Srivastava, K.; Svane, N.; Ding, M.; Larsen, O.N.; Sober, S.J.; Švec, J.G.

2015-01-01

As animals vocalize, their vocal organ transforms motor commands into vocalizations for social communication. In birds, the physical mechanisms by which vocalizations are produced and controlled remain unresolved because of the extreme difficulty in obtaining in vivo measurements. Here, we introduce an ex vivo preparation of the avian vocal organ that allows simultaneous high-speed imaging, muscle stimulation and kinematic and acoustic analyses to reveal the mechanisms of vocal production in birds across a wide range of taxa. Remarkably, we show that all species tested employ the myoelastic-aerodynamic (MEAD) mechanism, the same mechanism used to produce human speech. Furthermore, we show substantial redundancy in the control of key vocal parameters ex vivo, suggesting that in vivo vocalizations may also not be specified by unique motor commands. We propose that such motor redundancy can aid vocal learning and is common to MEAD sound production across birds and mammals, including humans. PMID:26612008

Universal mechanisms of sound production and control in birds and mammals.

PubMed

Elemans, C P H; Rasmussen, J H; Herbst, C T; Düring, D N; Zollinger, S A; Brumm, H; Srivastava, K; Svane, N; Ding, M; Larsen, O N; Sober, S J; Švec, J G

2015-11-27

As animals vocalize, their vocal organ transforms motor commands into vocalizations for social communication. In birds, the physical mechanisms by which vocalizations are produced and controlled remain unresolved because of the extreme difficulty in obtaining in vivo measurements. Here, we introduce an ex vivo preparation of the avian vocal organ that allows simultaneous high-speed imaging, muscle stimulation and kinematic and acoustic analyses to reveal the mechanisms of vocal production in birds across a wide range of taxa. Remarkably, we show that all species tested employ the myoelastic-aerodynamic (MEAD) mechanism, the same mechanism used to produce human speech. Furthermore, we show substantial redundancy in the control of key vocal parameters ex vivo, suggesting that in vivo vocalizations may also not be specified by unique motor commands. We propose that such motor redundancy can aid vocal learning and is common to MEAD sound production across birds and mammals, including humans.

Mineralogical characterization of strata of the Meade Peak phosphatic shale member of the Permian Phosphoria Formation: channel and individual rock samples of measured section J and their relationship to measured sections A and B, central part of Rasmussen Ridge, Caribou County, Idaho

USGS Publications Warehouse

Knudsen, A.C.; Gunter, M.E.; Herring, J.R.; Grauch, R.I.

2002-01-01

The Permian Phosphoria Formation of southeastern Idaho hosts one of the largest phosphate deposits in the world. Despite the economic significance of this Formation, the fine-grained nature of the phosphorite has discouraged detailed mineralogical characterization and quantification studies. Recently, selenium and other potentially toxic trace elements in mine wastes have drawn increased attention to this formation, and motivated additional study. This study uses powder X-ray diffraction (XRD), with Rietveld quantification software, to quantify and characterize the mineralogy of composite channel samples and individual samples collected from the stratigraphic sections measured by the U.S. Geological Survey in the Meade Peak Member of the Permian Phosphoria Formation at the Enoch Valley mine on Rasmussen Ridge, approximately 15 miles northeast of Soda Springs, Idaho.

Mars Science Laboratory (MSL) Entry, Descent, and Landing Instrumentation (MEDLI): Complete Flight Data Set

NASA Technical Reports Server (NTRS)

Cheatwood, F. McNeil; Bose, Deepak; Karlgaard, Christopher D.; Kuhl, Christopher A.; Santos, Jose A.; Wright, Michael J.

2014-01-01

The Mars Science Laboratory (MSL) entry vehicle (EV) successfully entered the Mars atmosphere and landed the Curiosity rover safely on the surface of the planet in Gale crater on August 6, 2012. MSL carried the MSL Entry, Descent, and Landing (EDL) Instrumentation (MEDLI). MEDLI delivered the first in-depth understanding of the Mars entry environments and the response of the entry vehicle to those environments. MEDLI was comprised of three major subsystems: the Mars Entry Atmospheric Data System (MEADS), the MEDLI Integrated Sensor Plugs (MISP), and the Sensor Support Electronics (SSE). Ultimately, the entire MEDLI sensor suite consisting of both MEADS and MISP provided measurements that were used for trajectory reconstruction and engineering validation of aerodynamic, atmospheric, and thermal protection system (TPS) models in addition to Earth-based systems testing procedures. This report contains in-depth hardware descriptions, performance evaluation, and data information of the three MEDLI subsystems.

Potential for bias in using hybrids between common carp (Cyprinus carpio) and goldfish (Carassius auratus) in endocrine studies: a first report of hybrids in Lake Mead, Nevada, U.S.A

USGS Publications Warehouse

Goodbred, Steven L.; Patino, Reynaldo; Orsak, Erik; Sharma, Prakash; Ruessler, Shane

2013-01-01

During a 2008 study to assess endocrine and reproductive health of common carp (Cyprinus carpio) in Lake Mead, Nevada (U.S.A.) we identified two fish, one male and one female, as hybrids with goldfish (Carassius auratus) based on morphology, lateral line scale count, and lack of anterior barbels. Gross examination of the female hybrid ovaries indicated presence of vitellogenic ovarian follicles; whereas histological evaluation of the male hybrid testes showed lobule-like structures with open lumens but without germ cells, suggesting it was sterile. Because common carp/goldfish hybrids are more susceptible to gonadal tumors and may have different endocrine profiles than common carp, researchers using common carp as a model for endocrine/reproductive studies should be aware of the possible presence of hybrids.

A neo-Meadian approach to human agency: relating the social and the psychological in the ontogenesis of perspective-coordinating persons.

PubMed

Martin, Jack; Gillespie, Alex

2010-09-01

How can human agency be reconciled with bio-physical determinism? Starting with a discussion of the long standing debate between determinism and agency, we argue that the seeds of a reconciliation can be found in George Herbert Mead's ideas concerning social acts, perspectives, differentiation, self-other interactivity, and conscious understanding. Drawing on more recent reformulations of Mead's ideas, we present an integrated account of the ontogenesis of human agency. Human agency, we argue, should be conceptualized in terms of distanciation from immediate experience, and we show how social interactions, institutions and symbolic resources foster the development of agency in increasingly complex ways. We conclude by situating our work in relation to other developmental accounts and the larger project of theorizing and empirically supporting a compatibilist rendering of human agency as the "determined" self-determination of persons.

Effect of heat treatment and storage conditions on mead composition.

PubMed

Kahoun, David; Řezková, Soňa; Královský, Josef

2017-03-15

The effects of heat treatment and storage conditions on the composition of pure mead (honey wine) made from only honey and water were investigated. Heat treatment experiments were performed at 7 different temperatures ranging from 40°C to100°C with 10°C increments for 60min. Storage condition experiments were performed at room temperature (20-25°C) in daylight without direct sunlight and in darkness in a refrigerator at 4°C for 1, 2, 4 and 12weeks. The parameters evaluated were phenolic compounds, peak area of unidentified compounds, 5-hydroxymethylfurfural content and antioxidant capacity. Significant changes in compound content were observed in the case of 6 identified compounds and 9 unidentified compounds. However, the antioxidant activity was not affected by the heat treatments or storage at room temperature. Copyright © 2016 Elsevier Ltd. All rights reserved.

Neurological Consequences of Cytomegalovirus Infection

MedlinePlus

... viruses that causes cold sores (herpes simplex virus), infectious mononucleosis (Epstein-Barr virus), and chickenpox/shingles (varicella zoster ... viruses that causes cold sores (herpes simplex virus), infectious mononucleosis (Epstein-Barr virus), and chickenpox/shingles (varicella zoster ...

Serum herpes simplex antibodies

MedlinePlus

... causes cold sores (oral herpes). HSV-2 causes genital herpes. How the Test is Performed A blood sample ... person has ever been infected with oral or genital herpes . It looks for antibodies to herpes simplex virus ...

Latency of Herpes Simplex Virus in Absence of Neutralizing Antibody: Model for Reactivation

NASA Astrophysics Data System (ADS)

Sekizawa, Tsuyoshi; Openshaw, Harry; Wohlenberg, Charles; Notkins, Abner Louis

1980-11-01

Mice inoculated with herpes simplex virus (type 1) by the lip or corneal route and then passively immunized with rabbit antibody to herpes simplex virus developed a latent infection in the trigeminal ganglia within 96 hours. Neutralizing antibody to herpes simplex virus was cleared from the circulation and could not be detected in most of these mice after 2 months. Examination of ganglia from the antibody-negative mice revealed latent virus in over 90 percent of the animals, indicating that serum neutralizing antibody is not necessary to maintain the latent state. When the lips or corneas of these mice were traumatized, viral reactivation occurred in up to 90 percent of the mice, as demonstrated by the appearance of neutralizing antibody. This study provides a model for identifying factors that trigger viral reactivation.

The Type I Interferon Response and Age-Dependent Susceptibility to Herpes Simplex Virus Infection.

PubMed

Giraldo, Daniel; Wilcox, Douglas R; Longnecker, Richard

2017-05-01

Herpes simplex virus type 1 (HSV-1) is a highly prevalent human neurotropic pathogen. HSV-1 infection is associated with a variety of diseases ranging from benign orolabial lesions to more serious and even life-threatening conditions such as herpes simplex keratitis and herpes simplex encephalitis (HSE). HSE is a rare occurrence among healthy adult individuals, but newborns are a particularly susceptible population. Type I IFN signaling has been identified as a crucial component of the innate immune response to the control of HSV-1 infection. In this study, we review the contribution of the type I IFN response to controlling HSV-1 infection, and differences in the early host response between adults and newborns that may contribute to the increased susceptibility to infection and central nervous system disease in newborns.

[The Spanish Society of Paediatric Infectious Diseases guidelines on the prevention, diagnosis and treatment of neonatal herpes simplex infections].

PubMed

2018-02-13

Neonatal herpes simplex virus infections are rare, but are associated with significant morbidity and mortality. Most newborns acquire herpes simplex virus infection in the peripartum period. For peripartum transmission to occur, women must be shedding the virus in their genital tracts symptomatically or asymptomatically around the time of delivery. There are evidence-based interventions in pregnancy to prevent the transmission to the newborn. Caesarean section should be performed in the presence of herpetic lesions, and antiviral prophylaxis in the last weeks of pregnancy is recommended to suppress genital tract herpes simplex virus at the time of delivery. The diagnosis and early treatment of neonatal herpes simplex virus infections require a high index of suspicion, especially in the absence of skin lesions. It is recommended to rule out herpes simplex virus infections in those newborns with mucocutaneous lesions, central nervous system involvement, or septic appearance. The prognosis of newborns with skin, eye, and/or mouth disease in the high-dose acyclovir era is very good. Antiviral treatment not only improves mortality rates in disseminated and central nervous system disease, but also improves the rates of long-term neurodevelopmental impairment in the cases of disseminated disease. Interestingly, a 6-month suppressive course of oral acyclovir following the acute infection has improved the neurodevelopmental prognosis in patients with CNS involvement. Copyright © 2017 Asociación Española de Pediatría. Publicado por Elsevier España, S.L.U. All rights reserved.

Improved Genetic Algorithm Based on the Cooperation of Elite and Inverse-elite

NASA Astrophysics Data System (ADS)

Kanakubo, Masaaki; Hagiwara, Masafumi

In this paper, we propose an improved genetic algorithm based on the combination of Bee system and Inverse-elitism, both are effective strategies for the improvement of GA. In the Bee system, in the beginning, each chromosome tries to find good solution individually as global search. When some chromosome is regarded as superior one, the other chromosomes try to find solution around there. However, since chromosomes for global search are generated randomly, Bee system lacks global search ability. On the other hand, in the Inverse-elitism, an inverse-elite whose gene values are reversed from the corresponding elite is produced. This strategy greatly contributes to diversification of chromosomes, but it lacks local search ability. In the proposed method, the Inverse-elitism with Pseudo-simplex method is employed for global search of Bee system in order to strengthen global search ability. In addition, it also has strong local search ability. The proposed method has synergistic effects of the three strategies. We confirmed validity and superior performance of the proposed method by computer simulations.

Experiences with the hydraulic design of the high specific speed Francis turbine

NASA Astrophysics Data System (ADS)

Obrovsky, J.; Zouhar, J.

2014-03-01

The high specific speed Francis turbine is still suitable alternative for refurbishment of older hydro power plants with lower heads and worse cavitation conditions. In the paper the design process of such kind of turbine together with the results comparison of homological model tests performed in hydraulic laboratory of ČKD Blansko Engineering is introduced. The turbine runner was designed using the optimization algorithm and considering the high specific speed hydraulic profile. It means that hydraulic profiles of the spiral case, the distributor and the draft tube were used from a Kaplan turbine. The optimization was done as the automatic cycle and was based on a simplex optimization method as well as on a genetic algorithm. The number of blades is shown as the parameter which changes the resulting specific speed of the turbine between ns=425 to 455 together with the cavitation characteristics. Minimizing of cavitation on the blade surface as well as on the inlet edge of the runner blade was taken into account during the design process. The results of CFD analyses as well as the model tests are mentioned in the paper.

Optimising mobile phase composition, its flow-rate and column temperature in HPLC using taboo search.

PubMed

Guillaume, Y C; Peyrin, E

2000-03-06

A chemometric methodology is proposed to study the separation of seven p-hydroxybenzoic esters in reversed phase liquid chromatography (RPLC). Fifteen experiments were found to be necessary to find a mathematical model which linked a novel chromatographic response function (CRF) with the column temperature, the water fraction in the mobile phase and its flow rate. The CRF optimum was determined using a new algorithm based on Glover's taboo search (TS). A flow-rate of 0.9 ml min(-1) with a water fraction of 0.64 in the ACN-water mixture and a column temperature of 10 degrees C gave the most efficient separation conditions. The usefulness of TS was compared with the pure random search (PRS) and simplex search (SS). As demonstrated by calculations, the algorithm avoids entrapment in local minima and continues the search to give a near-optimal final solution. Unlike other methods of global optimisation, this procedure is generally applicable, easy to implement, derivative free, conceptually simple and could be used in the future for much more complex optimisation problems.

Amino-terminal sequence of glycoprotein D of herpes simplex virus types 1 and 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eisenberg, R.J.; Long, D.; Hogue-Angeletti, R.

1984-01-01

Glycoprotein D (gD) of herpes simplex virus is a structural component of the virion envelope which stimulates production of high titers of herpes simplex virus type-common neutralizing antibody. The authors caried out automated N-terminal amino acid sequencing studies on radiolabeled preparations of gD-1 (gD of herpes simplex virus type 1) and gD-2 (gD of herpes simplex virus type 2). Although some differences were noted, particularly in the methionine and alanine profiles for gD-1 and gD-2, the amino acid sequence of a number of the first 30 residues of the amino terminus of gD-1 and gD-2 appears to be quite similar.more » For both proteins, the first residue is a lysine. When we compared out sequence data for gD-1 with those predicted by nucleic acid sequencing, the two sequences could be aligned (with one exception) starting at residue 26 (lysine) of the predicted sequence. Thus, the first 25 amino acids of the predicted sequence are absent from the polypeptides isolated from infected cells.« less

Fabrication and investigation of electrochromatographic columns with a simplex configuration.

PubMed

Liu, Qing; Yang, Lijun; Wang, Qiuquan; Zhang, Bo

2014-07-04

Duplex capillary columns with a packed and an open section are widely used in electrochromatography (CEC). The duplex column configuration leads to non-uniform voltage drop, electrical field distribution and separation performance. It also adds to the complexity in understanding and optimizing electrochromatographic process. In this study, we introduced a simplex column configuration based on single particle fritting technology. The new column configuration has an essentially uniform packed bed through the entire column length, with only 1mm length left unpacked serving as the optical detection window. The study shows that a simplex column has higher separation efficiency than a duplex column, especially at the high voltage range, due to the consistent distribution of electrical field over the column length. In comparison to the duplex column, the simplex column presented a lower flow rate at the same applied voltage, suggesting that an open section may support a higher speed than a packed section. In practice, the long and short ends of the simplex column could be used as independent CEC columns respectively. This "two-in-one" bi-functional column configuration provided extra flexibilities in selecting and optimizing electrochromatographic conditions. Copyright © 2014 Elsevier B.V. All rights reserved.

Prevalence of herpes simplex, Epstein Barr and human papilloma viruses in oral lichen planus.

PubMed

Yildirim, Benay; Sengüven, Burcu; Demir, Cem

2011-03-01

The aim of the present study was to assess the prevalence of Herpes Simplex virus, Epstein Barr virus and Human Papilloma virus -16 in oral lichen planus cases and to evaluate whether any clinical variant, histopathological or demographic feature correlates with these viruses. The study was conducted on 65 cases. Viruses were detected immunohistochemically. We evaluated the histopathological and demographic features and statistically analysed correlation of these features with Herpes Simplex virus, Epstein Barr virus and Human Papilloma virus-16 positivity. Herpes Simplex virus was positive in six (9%) cases and this was not statistically significant. The number of Epstein Barr virus positive cases was 23 (35%) and it was statistically significant. Human Papilloma virus positivity in 14 cases (21%) was statistically significant. Except basal cell degeneration in Herpes Simplex virus positive cases, we did not observe any significant correlation between virus positivity and demographic or histopathological features. However an increased risk of Epstein Barr virus and Human Papilloma virus infection was noted in oral lichen planus cases. Taking into account the oncogenic potential of both viruses, oral lichen planus cases should be detected for the presence of these viruses.

Difficulty Factors, Distribution Effects, and the Least Squares Simplex Data Matrix Solution

ERIC Educational Resources Information Center

Ten Berge, Jos M. F.

1972-01-01

In the present article it is argued that the Least Squares Simplex Data Matrix Solution does not deal adequately with difficulty factors inasmuch as the theoretical foundation is insufficient. (Author/CB)

Histogram-driven cupping correction (HDCC) in CT

NASA Astrophysics Data System (ADS)

Kyriakou, Y.; Meyer, M.; Lapp, R.; Kalender, W. A.

2010-04-01

Typical cupping correction methods are pre-processing methods which require either pre-calibration measurements or simulations of standard objects to approximate and correct for beam hardening and scatter. Some of them require the knowledge of spectra, detector characteristics, etc. The aim of this work was to develop a practical histogram-driven cupping correction (HDCC) method to post-process the reconstructed images. We use a polynomial representation of the raw-data generated by forward projection of the reconstructed images; forward and backprojection are performed on graphics processing units (GPU). The coefficients of the polynomial are optimized using a simplex minimization of the joint entropy of the CT image and its gradient. The algorithm was evaluated using simulations and measurements of homogeneous and inhomogeneous phantoms. For the measurements a C-arm flat-detector CT (FD-CT) system with a 30×40 cm2 detector, a kilovoltage on board imager (radiation therapy simulator) and a micro-CT system were used. The algorithm reduced cupping artifacts both in simulations and measurements using a fourth-order polynomial and was in good agreement to the reference. The minimization algorithm required less than 70 iterations to adjust the coefficients only performing a linear combination of basis images, thus executing without time consuming operations. HDCC reduced cupping artifacts without the necessity of pre-calibration or other scan information enabling a retrospective improvement of CT image homogeneity. However, the method can work with other cupping correction algorithms or in a calibration manner, as well.

'Catch it, encode it and measure it'.

PubMed

Mead, Donna

2005-01-01

Donna Mead, Head of School, School of Care Sciences, University of Glamorgan, explains how her early experiences as a ward sister gave her the drive and determination to seek research-based solutions to some of the conditions that she encountered.

76 FR 34273 - National Endowment for the Arts; National Council on the Arts 173rd Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-13

... Commander, 70 Intelligence Surveillance and Reconnaissance Wing, Fort Meade, MD on Blue Star Museums; by... discussion, it becomes necessary for the Council to discuss non-public commercial or financial information of...

15. Interior view of unoccupied controlled computer room looking at ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

15. Interior view of unoccupied controlled computer room looking at exit door and office; northwest corner of unoccupied portion; view to south. - Ellsworth Air Force Base, Mess & Administration Building, 2279 Risner Drive, Blackhawk, Meade County, SD

13. Detail of hangar door showing mount of sliding door ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. Detail of hangar door showing mount of sliding door leaves at overhead girder. Viedw to north-northeast. - Ellsworth Air Force Base, Readiness Hangar, Kenny Road, southeast corner of interstction with G Avenue, Blackhawk, Meade County, SD

Nitro-polycyclic aromatic hydrocarbon concentrations and sources in urban and suburban atmospheres of the Mid-Atlantic region

NASA Astrophysics Data System (ADS)

Bamford, Holly A.; Baker, Joel E.

Gas and particle phase concentrations of 26 nitro-PAHs were quantified in ambient air collected in downtown Baltimore, MD, an urban region, and in Fort Meade, MD, a suburban area 20 km south-southeast of Baltimore, during January and July 2001. Total (gas+particle) concentrations for individual nitro-PAH compounds varied by as much as five times from sample to sample within each month. 2-Nitrofluoranthene and 9-nitroanthracene were the most abundant of the nitro-PAHs quantitatively analyzed in the air at both sites, accounting for approximately half of the total nitro-PAH concentrations during January and July. Concentrations at Baltimore were on average two to three times higher than those measured at the Fort Meade site. Concentrations for most nitro-PAHs were higher in January than in July, suggesting a reduction in photodecay of nitro-PAHs during January promoted the accumulation of nitro-PAHs. Concentrations of nitro-PAHs produced from gas-phase reactions were significantly correlated with concentrations of oxides of nitrogen (NO x) measured simultaneously at the Fort Meade site. 3-Nitrophenanthrene and 4-nitrophenanthrene were negatively correlated with NO x and were the only nitro-PAHs correlated with O 3, suggesting a different formation mechanism for these compounds compared to the other nitro-PAHs found in this study. The relative contribution of gas-phase reactions and primary emission sources of nitro-PAHs were evaluated using source specific concentration ratios of 2-nitrofluoranthene and 1-nitropyrene (2-NF/1-NP). The mean ratios of 2-NF/1-NP at both sites were statistically higher in July than January, indicating gas-phase reactions were an important source of 2-nitrofluoranthene in the summer. However, in January, gas-phase reactions were reduced, the NO 3-initiated reaction in particular, and primary emissions may significantly contribute to ambient nitro-PAH levels. The two dominant gas-phase production pathways of nitro-PAHs from the OH and NO 3-initiated reactions were investigated using concentration ratios of 2-nitrofluoranthene and 2-nitropyrene (2-NF/2-NP). At both sites, 2-NF/2-NP ratios indicated that the daytime OH-initiated reaction was the dominant gas-phase formation pathway. The estimated contributions of nitro-PAHs produced through gas-phase reactions via the OH pathway during July were >45% and during January were >83% at both Fort Meade and Baltimore.

Gasoline-Related Compounds in Lakes Mead and Mohave, Nevada, 2004-06

USGS Publications Warehouse

Lico, Michael S.; Johnson, B. Thomas

2007-01-01

The distribution of man-made organic compounds, specifically gasoline-derived compounds, was investigated from 2004 to 2006 in Lakes Mead and Mohave and one of its tributary streams, Las Vegas Wash. Compounds contained in raw gasoline (benzene, toluene, ethylbenzene, xylenes; also known as BTEX compounds) and those produced during combustion of gasoline (polycyclic aromatic hydrocarbon compounds; also known as PAH compounds) were detected at every site sampled in Lakes Mead and Mohave. Water-quality analyses of samples collected during 2004-06 indicate that motorized watercraft are the major source of these organic compounds to the lakes. Concentrations of BTEX increase as the boating season progresses and decrease to less than detectable levels during the winter when few boats are on the water. Volatilization and microbial degradation most likely are the primary removal mechanisms for BTEX compounds in the lakes. Concentrations of BTEX compounds were highest at sampling points near marinas or popular launching areas. Methyl tert-butyl ether (MTBE) was detected during 2004 but concentrations decreased to less than the detection level during the latter part of the study; most likely due to the removal of MTBE from gasoline purchased in California. Distribution of PAH compounds was similar to that of BTEX compounds, in that, concentrations were highest at popular boating areas and lowest in areas where fewer boats traveled. PAH concentrations were highest at Katherine Landing and North Telephone Cove in Lake Mohave where many personal watercraft with carbureted two-stroke engines ply the waters. Lake-bottom sediment is not a sink for PAH as indicated by the low concentrations detected in sediment samples from both lakes. PAH compounds most likely are removed from the lakes by photochemical degradation. PAH compounds in Las Vegas Wash, which drains the greater Las Vegas metropolitan area, were present in relatively high concentrations in sediment from the upstream reaches. Concentrations of PAH compounds were low in water and sediment samples collected farther downstream, thus the bottom sediment in the upstream part of the wash may be an effective trap for these compounds. Bioavailable PAH compounds were present in all samples as determined using the Fluoroscan method. Microtox acute toxicity profiles indicated that Callville Bay in Lake Mead and the two Lake Mohave sites had only minor evidence that toxic compounds are present.

Varicella-zoster virus complements herpes simplex virus type 1 temperature-sensitive mutants.

PubMed Central

Felser, J M; Straus, S E; Ostrove, J M

1987-01-01

Varicella-zoster virus (VZV) can complement temperature-sensitive mutants of herpes simplex virus. Of seven mutants tested, two, carrying mutations in the immediate-early ICP4 and ICP27 proteins, were complemented. This complementation was not seen in coinfections with adenovirus type 5 or cytomegalovirus. Following transfection into CV-1 cells, a DNA fragment containing the VZV short repeat sequence complemented the ICP4 mutant. These data demonstrate a functional relationship between VZV and herpes simplex virus and have allowed localization of a putative VZV immediate-early gene. PMID:3023701

Study of mural painting isolates, leading to the transfer of 'Bacillus maroccanus' and 'Bacillus carotarum' to Bacillus simplex, emended description of Bacillus simplex, re-examination of the strains previously attributed to 'Bacillus macroides' and description of Bacillus muralis sp. nov.

PubMed

Heyrman, Jeroen; Logan, Niall A; Rodríguez-Díaz, Marina; Scheldeman, Patsy; Lebbe, Liesbeth; Swings, Jean; Heyndrickx, Marc; De Vos, Paul

2005-01-01

A group of 24 strains was isolated from deteriorated mural paintings situated in Spain (necropolis of Carmona) and Germany (church of Greene-Kreiensen). (GTG)5-PCR genomic fingerprinting was performed on these strains to assess their genomic variability and the strains were delineated into four groups. Representatives were studied by 16S rRNA gene sequencing and were found to be closely related to Bacillus simplex and the species 'Bacillus macroides' (strain NCIMB 8796) and 'Bacillus maroccanus' (names not validly published) according to a fasta search. The close similarity between B. simplex, 'B. macroides' NCIMB 8796, 'B. maroccanus' and the mural painting isolates was confirmed by additional (GTG)5-PCR, ARDRA, FAME and SDS-PAGE analyses. Furthermore, these techniques revealed that strains of 'Bacillus carotarum', another name that has not been validly published, also showed high similarity to this group of organisms. On the other hand, it was shown that the strains labelled 'B. macroides' in different collections do not all belong to the same species. Strain NCIMB 8796 can be allocated to B. simplex, while strain DSM 54 (=ATCC 12905) shares the highest 16S rRNA gene sequence similarity with Bacillus sphaericus and Bacillus fusiformis (both around 98.6 %). On the basis of further DNA-DNA hybridization data and the study of phenotypic characteristics, one group of five mural painting strains was attributed to a novel species in the genus Bacillus, for which the name Bacillus muralis sp. nov. is proposed. Finally, the remaining mural painting strains, one (LMG 18508=NCIMB 8796) of two strains belonging to 'B. macroides' and strains belonging to 'B. maroccanus' and 'B. carotarum' are allocated to the species B. simplex and an emended description of B. simplex is given.

[Infection and physico-chemical characteristics of Anisakis among marine fish caught in Zhoushan Fishery].

PubMed

Wang, Jian-yue; Zhang, Jun-he; Lin, Qi; Zhang, Qian-tong; He, Wei-xian; Li, Ke-feng; Xu, Xu

2010-09-01

To study the rates of infection and physicochemical characteristics of the third stage Anisakis simplex larvae among marine fish caught in Zhoushan Fishery. Fish were dissected to detect Anisakis larvae and identified morphologically. The survival tolerance of the third stage Anisakis simplex larvae in various medium, anthelmintic drug, temperature were studied in laboratory. The total infection rate of Anisakis simplex larvae in fish was 49.10%. High rates of Anisakis infection were observed in hairtails, Pneumatophorus japonicus, Miichthys milky, Argyrosomus argentatus and Muraenesox cinereus (infection rates > 90 percent). The infection intensity of Anisakis per fish varied from 1 to 114. The mean intensity of Anisakis larvae was 15.20 per fish. 3314 Anisakis were detected in 218 marine fish. The survival tolerance of the third stage Anisakis simplex larvae in various Medium, anthelmintic drug, temperature were observed in laboratory condition. The third stage Anisakis simplex larvae showed a strong endurance to stock condiment. The anisakicidal effects of the high purity wine were more effective than that of the low purity wine. The anisakicidal effects of 6.25 g/L mebendazole composite were more effective than that of 18.75 g/L and also more effective than those of other drugs. The third stage Anisakis simplex larvae could survive with length up to 9 h and 12 h in condition of -20°C, -10°C and very sensitive to high temperature treatment. However, they could barely survive in more than 11 s and 1 s under the temperature of 50°C and 60°C. The percentage of infection was fairly high for Anisakis larvae of marine fish caught in Zhoushan Fishery. The third stage Anisakis simplex larvae was shown to have a fairly good tolerance to the external environments. The marine fish were frozen under -20°C beyond 24 h before they were sold on market and cooked with high temperature seemed to be helpful for preventing and controlling effectively the infection of Anisakis.

Organic Chemical Concentrations and Reproductive Biomarkers in Common Carp (Cyprinus carpio) Collected from Two Areas in Lake Mead, Nevada, May 1999-May 2000

USGS Publications Warehouse

Goodbred, Steven L.; Leiker, Thomas J.; Patiño, Reynaldo; Jenkins, Jill A.; Denslow, Nancy D.; Orsak, Erik; Rosen, Michael R.

2007-01-01

The U.S. Geological Survey, in cooperation with the U.S. Fish and Wildlife Service, National Park Service, Bureau of Reclamation, and Nevada Department of Wildlife, collected and assessed data to determine the general health and reproductive status of common carp (Cyprinus carpio) at two study areas in Lake Mead, Nevada, during May 1999-May 2000. These data will form the basis of interpretations and provide a comparison for continuing studies on the health of the ecosystem in Lake Mead. One study area, Las Vegas Bay, is in the western part of Lake Mead. Las Vegas Bay receives inflows from Las Vegas Wash, which is predominantly tertiary-treated wastewater effluent, and to a lesser extent stormwater runoff from Las Vegas, Henderson, and other nearby communities, and from ground water underlying Las Vegas Valley. The other study area, Overton Arm, is in the northern extent of Lake Mead. Overton Arm receives inflow from the Virgin and Muddy Rivers, which historically are not influenced by wastewater effluent. Both sexes of common carp were collected bimonthly for 12 months using boat-mounted electrofishing gear (a direct electric current is used to temporarily immobilize fish for capture) to determine their health and reproductive status and any relation between these factors and environmental contaminants. This report presents fish tissue chemistry, organic chemical compound concentrations, and biomarker data for 83 male common carp collected from Las Vegas Bay, similar organic chemistry results for 15 male common carp, and similar biomarker measures for 80 male common carp collected from Overton Arm. Tissue chemistry results also are presented for 16 female common carp and biomarker measures for 79 female common carp collected from Las Vegas Bay, and tissue chemistry results for 15 female common carp and biomarker measures for 81 female common carp collected from Overton Arm. Thirty-three organic chemical compounds plus total concentrations for four groups of compounds (chlordanes, polychlorinated biphenyls [PCBs], brominated diphenyl ethers [BDEs], and triclosans) were analyzed from extracts of whole-body tissue using gas chromatography/mass spectrometry in male common carp from Las Vegas Bay during May 1999 through May 2000. All 33 compounds were detected in at least one sample of whole-body tissue from male common carp collected in Las Vegas Bay. In Overton Arm, 37 organic compounds plus total concentrations of three groups of compounds (PCBs, BDEs, and triclosans) were analyzed in male common carp where 20 (54 percent) of the compounds were detected. Sixteen of the 33 compounds detected in male common carp from Las Vegas Bay and 10 compounds detected in males from Overton Arm have the potential to disrupt the endocrine system in fish in Lake Mead. During May and June 1999, the mean concentration of all organic compounds detected in male common carp was 670 micrograms per kilogram from Las Vegas Bay and 109 micrograms per kilogram from Overton Arm. Twenty-seven organic compounds plus total PCBs were analyzed from extracts of whole-body tissue in female common carp collected in Las Vegas Bay and Overton Arm during May 1999. Twenty-four (86 percent) of these compounds were detected in at least one sample of whole-body tissue from female common carp collected from Las Vegas Bay while 10 (36 percent) chemical compounds were detected in female common carp from Overton Arm during that same period. Median concentrations of all chemical compounds were higher in female common carp from Las Vegas Bay compared to those collected from Overton Arm except Dacthal (DCPA), which was similar between sites. Biomarker measures obtained for male and female common carp include gonadosomatic index (percentage of gonad weight to total body weight), plasma vitellogenin (a phospholipid protein normally produced by female common carp and other oviparous fish), and condition factor [body weight/(fork length)3]. Biomarker measures for male c

[Herpetic folliculitis barbae. A rare cause of folliculitis].

PubMed

Anliker, M D; Itin, P

2003-03-01

Viral folliculitis is a rare disease usually caused by herpes simplex, herpes zoster and molluscum contagiosum in immune-compromised patients. An otherwise healthy 30 year old patient without history of herpes simplex contracted a folliculitis in the beard region after a flu-like illness. He had no oral or labial lesions but instead showed a crusty erythematous folliculitis confined to the beard region with small grouped vesicles on the neck and reactive cervical lymph nodes. Bacterial and mycological analysis from swabs were negative. The culture was positive for herpes simplex virus and the immune fluorescence showed HSV type 1. Systemic therapy with valaciclovir 2x 500 mg/d and lotio alba locally led to rapid improvement. When confronted with folliculitis, non-bacterial causes such as viral (herpes simplex, herpes zoster, molluscum contagiosum), mycological (pityrosporon, candida), demodex and eosinophilic follicultitis should be taken under consideration.

Mersalyl: a Diuretic with Antiviral Properties

PubMed Central

Kramer, M. J.; Cleeland, R.; Grunberg, E.

1975-01-01

Mersalyl (Salyrgan), an organic mercurial diuretic, was tested against human and animal viruses with in vivo model infections in mice and tissue culture systems. Mersalyl was active against coxsackieviruses A21 and B1 in mice if administered intraperitoneally immediately after infection. No effect was observed if intraperitoneal treatment was delayed 1 or 2 h postinfection, or if treatment was administered either subcutaneously or per os. Topical treatment with a 5% aqueous solution of mersalyl produced a statistically significant effect against herpes simplex dermatitis in mice but the substance was inactive against systemic infections in mice with herpes simplex as well as Columbia SK, influenza, Semliki Forest, and Sendai viruses. Contact inactivation of coxsackieviruses A21 and B1 and herpes simplex virus was observed, but mersalyl was inactive in tissue culture against coxackieviruses A21 and B1, herpes simplex, influenza, rhinovirus, Semliki Forest, Sendai, and vaccinia viruses. PMID:810082

Pediatric herpes simplex virus infections: an evidence-based approach to treatment.

PubMed

Sanders, Jennifer E; Garcia, Sylvia E

2014-01-01

Herpes simplex virus is a common virus that causes a variety of clinical presentations ranging from mild to life-threatening. Orolabial and genital herpes are common disorders that can often be managed in an outpatient setting; however, some patients do present to the emergency department with those conditions, and emergency clinicians should be aware of possible complications in the pediatric population. Neonatal herpes is a rare disorder, but prompt recognition and initiation of antiviral therapy is imperative, as the morbidity and mortality of the disease is high. Herpes encephalitis is an emergency that also requires a high index of suspicion to diagnose. Herpes simplex virus is also responsible for a variety of other clinical presentations, including herpes gladiatorum, herpetic whitlow, eczema herpeticum, and ocular herpes. This issue reviews the common clinical presentations of the herpes simplex virus, the life-threatening infections that require expedient identification and management, and recommended treatment regimens.

Retention of urine and sacral paraesthesia in anogenital herpes simplex infection.

PubMed

Edis, R H

1981-01-01

Two definite and 2 probable cases of anogenital herpes simplex and sacral radiculitis are described. Symptoms were typical and consisted of paraesthesia and neuralgic pain in the perineum and legs, urinary retention and constipation occurring within several days to a week after an anogenital herpetic eruption. However, at presentation only 1 case had an obvious history of anogenital herpes simplex. Neurological signs were not striking and consisted of a reduced appreciation of light touch and pin prick over the sacral dermatomes and in 2 cases reduced anal sphincter tone. CSF examination in 3 patients showed a lymphocytosis. Bladder catheterisation was required for up to 2 weeks in 2 patients. The paraesthesia persisted for weeks to months. It should be more widely recognised that anogenital herpes simplex, with sacral radiculitis, is probably the commonest cause of acute retention of urine in young sexually active people.

[Ulcerating Herpes simplex infections in intensive care patients].

PubMed

Fischer, M; Wohlrab, J; Radke, J; Marsch, W C; Soukup, J

2002-11-01

Herpes simplex infections are potentially a life-threatening situation for immunocompromised as well as critically ill patients. The correct diagnosis is made more difficult in comatose patients by the fact that the characteristic symptom of extreme pain cannot be registered. The clinical dermatological findings (polycyclic configuration, easily bleeding ulcers) are thus especially important in patients under intensive care conditions. As examples, the cases of 3 critically ill patients (subarachnoid bleeding or head injury) developing therapy-resistant, flat sacral or perioral skin ulcers with peripheral blisters are presented. Herpes simplex virus was confirmed immunohistologically and in the smear test. All patients subsequently died. These cases emphasize that patients in the intensive care unit are in danger of developing a chronic persistent Herpes simplex infection due to latent immunosuppression. Chronic persistent Herpes infections may be underrated in intensive therapy, and must always be ruled out in case of therapy-resistant erosions or ulcerations.

A 9 year-old girl with herpes simplex virus type 2 acute retinal necrosis treated with intravitreal foscarnet.

PubMed

King, John; Chung, Mina; DiLoreto, David A

2007-01-01

A 9-year-old girl presented with a 2-week history of redness in the left eye. Examination revealed vitritis, retinal whitening, vasculitis, and optic nerve head edema. Polymerase chain reaction testing of the aqueous fluid revealed herpes simplex virus type 2. The retinitis was controlled with intravenous acyclovir and intravitreal foscarnet. The clinical course was complicated by retinal neovascularization and vitreous hemorrhage, which was treated by pars plana vitrectomy and endolaser. While there are few case reports of herpes simplex virus type 2 retinitis in children, this one is unique for the following reasons: it is the first reported case of herpes simplex virus type 2 retinitis in a child less than 10 years old without a previous history of neonatal infection or central nervous system involvement; no other children have been reported to have been treated with intravitreal foscarnet; and retinal neovascularization complicated the recovery.

Anisakis simplex: from Obscure Infectious Worm to Inducer of Immune Hypersensitivity

PubMed Central

Audicana, M. Teresa; Kennedy, Malcolm W.

2008-01-01

Summary: Infection of humans with the nematode worm parasite Anisakis simplex was first described in the 1960s in association with the consumption of raw or undercooked fish. During the 1990s it was realized that even the ingestion of dead worms in food fish can cause severe hypersensitivity reactions, that these may be more prevalent than infection itself, and that this outcome could be associated with food preparations previously considered safe. Not only may allergic symptoms arise from infection by the parasites (“gastroallergic anisakiasis”), but true anaphylactic reactions can also occur following exposure to allergens from dead worms by food-borne, airborne, or skin contact routes. This review discusses A. simplex pathogenesis in humans, covering immune hypersensitivity reactions both in the context of a living infection and in terms of exposure to its allergens by other routes. Over the last 20 years, several studies have concentrated on A. simplex antigen characterization and innate as well as adaptive immune response to this parasite. Molecular characterization of Anisakis allergens and isolation of their encoding cDNAs is now an active field of research that should provide improved diagnostic tools in addition to tools with which to enhance our understanding of pathogenesis and controversial aspects of A. simplex allergy. We also discuss the potential relevance of parasite products such as allergens, proteinases, and proteinase inhibitors and the activation of basophils, eosinophils, and mast cells in the induction of A. simplex-related immune hypersensitivity states induced by exposure to the parasite, dead or alive. PMID:18400801

Association of anti-herpes simplex virus IgG in tears and serum with clinical presentation in patients with presumed herpetic simplex keratitis.

PubMed

Borderie, Vincent M; Gineys, Raquel; Goldschmidt, Pablo; Batellier, Laurence; Laroche, Laurent; Chaumeil, Christine

2012-11-01

To assess the clinical relevance of tear anti-herpes simplex virus (HSV) antibody measurement for the diagnosis of herpes simplex keratitis. Records of 364 patients clinically suspect of HSV-related keratitis who had tear anti-HSV IgG assessment (tear-quantified anti-HSV IgG/filtrated IgG ratio) in our institution between January 2000 and August 2008 were retrospectively analyzed. Patients were classified into 4 groups as follows: group 1, anti-HSV IgG negative in serum and tears; group 2, anti-HSV IgG negative in tears and positive in serum; group 3, anti-HSV IgG nonsignificantly positive in tears and positive in serum; and group 4, anti-HSV IgG significantly positive in serum and tears. Randomly selected patient charts from each group were reviewed for clinical data. The prevalence of anti-HSV IgG in blood increased with age from >70% before 20 years to 95% after 70 years. The prevalence of anti-HSV IgG in tears increased with age from 20% before 20 years to >50% after 70 years. The presence (either significant or not) of anti-HSV IgG in tears was significantly associated with decreased corneal sensation, presence of stromal opacities, and with neurotrophic keratitis. Logistic regression showed no significant association between age and clinical signs except for herpetic ulcers and herpetic necrotizing keratitis. Tear production of anti-HSV IgG increases with age, and it is associated with sequelae of herpes simplex keratitis. Conversely, it is poorly associated with clinical signs of acute herpes simplex keratitis.

Mycosis Inhibits Cannibalism by Melanoplus sanguinipes, M. differentialis, Schistocerca americana, and Anabrus simplex

PubMed Central

Jaronski, Stefan T.

2013-01-01

Cannibalism is common among the Acrididae and the Mormon cricket, Anabrus simplex Haldeman (Orthoptera: Tettigoniidae). This behavior has been proposed as a mechanism for the horizontal transmission of Microsporida and entomopathogenic fungi. Aanecdotal observations suggested that the migratory grasshopper, Melanoplus sanguinipes Fabricius (Acrididae), and A. simplex did not eat cadavers that had been killed by insect pathogenic fungi. The hypothesis tested was that A. simplex or M. sanguinipes would not cannibalize individuals freshly killed by the entomopathogenic fungi, Beauveria bassiana Bals.-Criv. (Vuill.) (Hypocreales: Clavicipitaceae), or Metarhizium acridum (Driver and Milner) Bischoff, Rehner, and Humber. Cannibalism was examined in a series of no-choice tests with individual insects. Test insects included healthy adults of M. sanguinipes; the differential grasshopper, M. differentialis (Thomas); the American grasshopper, Schistocerca americana (Drury) (Acrididae); and A. simplex. Individual, starved Acrididae or A. simplex were confined in small cages with either a fungus-killed (but unsporulated) or uninfected cadaver. The insects were then observed periodically for the first 4 hr. After 24 hr, the cadavers were scored for the degree to which they had been consumed. Very few mycotic cadavers were fed upon by the healthy insects, and, at most only the tarsi were eaten. All four species generally refused to eat fungus-infected cadavers. In contrast, freeze-killed cadavers were partly or entirely consumed by most of the test insects, often within a few hours. Transmission of infection through contact in these tests was between 0–18.9%, depending upon the fungus and insect species, and was lower than the prevalence of cannibalism in all cases. PMID:24786183

Design and evaluation of a multi-epitope assembly Peptide (MEAP) against herpes simplex virus type 2 infection in BALB/c mice

PubMed Central

2011-01-01

Background Human herpes simplex virus (HSV) 1 and 2 causes oral, ocular, or genital infections, which remains a significant health problem worldwide. HSV-1 and -2 infections in humans range from localized skin infections of the oral, ocular, and genital regions to severe and often disseminated infections in immunocompromised hosts. Epitope based vaccination is a promising mean to achieve protective immunity and to avoid infections with Human herpes simplex virus type 2 (HSV-2). Methods The twelve selected epitopes, six B cell epitopes from different glycoprotein of HSV-2 (amino acid residues 466-473 (EQDRKPRN) from envelope glycoprotein B, 216-223 (GRTDRPSA) from C, 6-18 (DPSLKMADPNRFR) from D, 483-491 (DPPERPDSP) from E, 572-579 (EPPDDDDS) from G and 286-295 (CRRRYRRPRG) from I glycoprotein of HSV-2), four CD4+ T cell epitopes (amino acid residues 21-28 (NLPVLDQL) from D, 162-177 (KDVTVSQVWFGHRYSQ) from B, 205-224 (KAYQQGVTVDSIGMLPRFIP) from D and 245-259 (KPPYTSTLLPPELSD) from D) and two CD8+ T cell epitopes (amino acid residues 10-20 (KMADPNRFRGK) from D and 268-276 (ALLEDPAGT) from D), are responsible for the elicitation of the neutralizing antibodies and cytotoxic T lymphocytes (CTLs) that impart protective immunity to the host. In this study, all above epitopes were inserted into the extracellular fragment (amino acid residues 1-290) of HSV-2 glycoprotein D to construct multi-epitope assembly peptides (MEAPs) by replacing some non-epitope amino acid sequences. The epitope independency of the MEAPs was predicted by three-dimensional software algorithms. The gene of the selected MEAP was expressed in E.coli BL21(DE3), and its protective efficacy against HSV-2 infection was assessed in BALB/c mice. Results The MEAP, with each inserted epitopes independently displayed on the molecule surface, was selected as candidate proteins. The results showed that the MEAP was highly immunogenic and could elicit high titer neutralizing antibodies and cell-mediated immune responses. Conclusions The MEAP provided complete protection against infection with HSV-2 in mice, which indicates that it might be a potential candidate vaccine against HSV-2. PMID:21575169

77 FR 53231 - National Register of Historic Places; Notification of Pending Nominations and Related Actions

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-31

... School, Old, 301 Harmon Ave., Fort Lauderdale, 12000790 Polk County Lewis, W. Henry, House, 424 N. Oak St., Fort Meade, 12000791 IOWA Clinton County Clinton High School and Public Library (Clinton, Iowa MPS...

11. Interior view of former mess hall; showing closed doorway ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. Interior view of former mess hall; showing closed doorway to former food storage; near northwest corner of building on main floor; view to east. - Ellsworth Air Force Base, Mess & Administration Building, 1561 Ellsworth Street, Blackhawk, Meade County, SD

7. Interior view of open secretarial space looking toward offices ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. Interior view of open secretarial space looking toward offices and exterior door; showing opened doorway to office; northwest corner of west wing; view to west. - Ellsworth Air Force Base, Administration Office, 2704 George Drive, Blackhawk, Meade County, SD

The Crisis of Self: America's Secret War

ERIC Educational Resources Information Center

Mead, Margaret

1974-01-01

This is a speech delivered by Mead at the 1973 Congress for Recreation and Parks. The major theme of the speech is that to lose touch with the natural world is to lose touch with one's self and one's humanity. (Editors/JA)

On the existence of binary simplex codes. [using combinatorial construction

NASA Technical Reports Server (NTRS)

Taylor, H.

1977-01-01

Using a simple combinatorial construction, the existence of a binary simplex code with m codewords for all m is greater than or equal to 1 is proved. The problem of the shortest possible length is left open.

IL-12 Expressing oncolytic herpes simplex virus promotes anti-tumor activity and immunologic control of metastatic ovarian cancer in mice.

PubMed

Thomas, Eric D; Meza-Perez, Selene; Bevis, Kerri S; Randall, Troy D; Gillespie, G Yancey; Langford, Catherine; Alvarez, Ronald D

2016-10-27

Despite advances in surgical aggressiveness and conventional chemotherapy, ovarian cancer remains the most lethal cause of gynecologic cancer mortality; consequently there is a need for new therapeutic agents and innovative treatment paradigms for the treatment of ovarian cancer. Several studies have demonstrated that ovarian cancer is an immunogenic disease and immunotherapy represents a promising and novel approach that has not been completely evaluated in ovarian cancer. Our objective was to evaluate the anti-tumor activity of an oncolytic herpes simplex virus "armed" with murine interleukin-12 and its ability to elicit tumor-specific immune responses. We evaluated the ability of interleukin-12-expressing and control oncolytic herpes simplex virus to kill murine and human ovarian cancer cell lines in vitro. We also administered interleukin-12-expressing oncolytic herpes simplex virus to the peritoneal cavity of mice that had developed spontaneous, metastatic ovarian cancer and determined overall survival and tumor burden at 95 days. We used flow cytometry to quantify the tumor antigen-specific CD8 + T cell response in the omentum and peritoneal cavity. All ovarian cancer cell lines demonstrated susceptibility to oncolytic herpes simplex virus in vitro. Compared to controls, mice treated with interleukin-12-expressing oncolytic herpes simplex virus demonstrated a more robust tumor antigen-specific CD8 + T-cell immune response in the omentum (471.6 cells vs 33.1 cells; p = 0.02) and peritoneal cavity (962.3 cells vs 179.5 cells; p = 0.05). Compared to controls, mice treated with interleukin-12-expressing oncolytic herpes simplex virus were more likely to control ovarian cancer metastases (81.2 % vs 18.2 %; p = 0.008) and had a significantly longer overall survival (p = 0.02). Finally, five of 6 mice treated with interleukin-12-expressing oHSV had no evidence of metastatic tumor when euthanized at 6 months, compared to two of 4 mice treated with sterile phosphate buffer solution. Our pilot study demonstrates that an interleukin-12-expressing oncolytic herpes simplex virus effectively kills both murine and human ovarian cancer cell lines and promotes tumor antigen-specific CD8 + T-cell responses in the peritoneal cavity and omentum, leading to reduced peritoneal metastasis and improved survival in a mouse model.

Projective-Dual Method for Solving Systems of Linear Equations with Nonnegative Variables

NASA Astrophysics Data System (ADS)

Ganin, B. V.; Golikov, A. I.; Evtushenko, Yu. G.

2018-02-01

In order to solve an underdetermined system of linear equations with nonnegative variables, the projection of a given point onto its solutions set is sought. The dual of this problem—the problem of unconstrained maximization of a piecewise-quadratic function—is solved by Newton's method. The problem of unconstrained optimization dual of the regularized problem of finding the projection onto the solution set of the system is considered. A connection of duality theory and Newton's method with some known algorithms of projecting onto a standard simplex is shown. On the example of taking into account the specifics of the constraints of the transport linear programming problem, the possibility to increase the efficiency of calculating the generalized Hessian matrix is demonstrated. Some examples of numerical calculations using MATLAB are presented.

Minimization of three-dimensional beam emittance growth in rare-isotope accelerator

NASA Astrophysics Data System (ADS)

Oh, B. H.; Yoon, M.

2016-12-01

In this paper, we describe a research to minimize the three-dimensional (3D) emittance growth (EG) in the RAON accelerator, a heavy ion accelerator currently being developed in Korea to produce various rare isotopes. The emittance minimization is performed using the multi-objective genetic algorithm and the simplex method. We use them to analyze the driver linac for the in-flight fragmentation separator of the RAON facility and show that redesign of the 90-degree bending section of the RAON accelerator together with adjustment of optics in the upstream and downstream superconducting linacs can limit the 3D EG to 20 % in the entire region of the driver linac. Effects of various magnet and rf accelerating cavity errors on the beam-EG are also discussed.

NASA/RAE collaboration on nonlinear control using the F-8C digital fly-by-wire aircraft

NASA Technical Reports Server (NTRS)

Butler, G. F.; Corbin, M. J.; Mepham, S.; Stewart, J. F.; Larson, R. R.

1983-01-01

Design procedures are reviewed for variable integral control to optimize response (VICTOR) algorithms and results of preliminary flight tests are presented. The F-8C aircraft is operated in the remotely augmented vehicle (RAV) mode, with the control laws implemented as FORTRAN programs on a ground-based computer. Pilot commands and sensor information are telemetered to the ground, where the data are processed to form surface commands which are then telemetered back to the aircraft. The RAV mode represents a singlestring (simplex) system and is therefore vulnerable to a hardover since comparison monitoring is not possible. Hence, extensive error checking is conducted on both the ground and airborne computers to prevent the development of potentially hazardous situations. Experience with the RAV monitoring and validation procedures is described.

Simplex-stochastic collocation method with improved scalability

NASA Astrophysics Data System (ADS)

Edeling, W. N.; Dwight, R. P.; Cinnella, P.

2016-04-01

The Simplex-Stochastic Collocation (SSC) method is a robust tool used to propagate uncertain input distributions through a computer code. However, it becomes prohibitively expensive for problems with dimensions higher than 5. The main purpose of this paper is to identify bottlenecks, and to improve upon this bad scalability. In order to do so, we propose an alternative interpolation stencil technique based upon the Set-Covering problem, and we integrate the SSC method in the High-Dimensional Model-Reduction framework. In addition, we address the issue of ill-conditioned sample matrices, and we present an analytical map to facilitate uniformly-distributed simplex sampling.

Amplification of Herpes Simplex Virus Types 1 and 2 and Human Herpes Virus Type 5 Polymerase Gene Segment From Formalin-Fixed Brain Tissue From Alzheimer’s Disease Patients

DTIC Science & Technology

2005-08-01

The neuronal nitric oxide synthase (NOS1) gene target was amplified and sequenced in all samples tested, in addition to HSV1 , HSV2 , or Human Herpes...Triphosphate DNA Deoxyribonucleic acid GAPDH Glyceraldehyde-3 -phosphate dehydrogenase HSV Herpes Simplex Virus HSV1 Herpes Simplex Virus Type 1 HSV2 Herpes... HSV2 ) share 50-70 % homology. HSV1 is primarily associated with oral and ocular lesions, while HSV2 is primarily associated with genital and anal lesions

T cell-macrophage interaction in arginase-mediated resistance to herpes simplex virus.

PubMed

Bonina, L; Nash, A A; Arena, A; Leung, K N; Wildy, P

1984-09-01

Peritoneal macrophages activated by-products derived from a herpes simplex virus-specific helper T cell clone were used to investigate intrinsic and extrinsic resistance mechanisms to herpes simplex virus type 1 infection in vitro. T cell-activated macrophages produced fewer infective centres, indicating enhanced intrinsic resistance, and markedly reduced the growth of virus in a permissive cell line. The reduction in virus growth correlated with the depletion of arginine in the support medium, presumably resulting from increased arginase production by activated macrophages. The significance of these findings for antiviral immunity in vivo is discussed.

Herpes Simplex Virus Infections of the Central Nervous System.

PubMed

Whitley, Richard J

2015-12-01

This article summarizes knowledge of herpes simplex virus (HSV) infections of the central nervous system (CNS). Disease pathogenesis, detection of DNA polymerase chain reaction (PCR) for diagnosis and prognosis, and approaches to therapy warrant consideration. HSV infection of the CNS is one of few treatable viral diseases. Clinical trials indicate that outcome following neonatal herpes simplex virus type 2 (HSV-2) infections of the CNS is significantly improved when 6 months of suppressive oral acyclovir therapy follows IV antiviral therapy. In contrast, herpes simplex virus type 1 (HSV-1) infections of the brain do not benefit from extended oral antiviral therapy. This implies a difference in disease pathogenesis between HSV-2 and HSV-1 infections of the brain. PCR detection of viral DNA in the CSF is the gold standard for diagnosis. Use of PCR is now being adopted as a basis for determining the duration of therapy in the newborn. HSV infections are among the most common encountered by humans; seropositivity occurs in 50% to 90% of adult populations. Herpes simplex encephalitis, however, is an uncommon result of this infection. Since no new antiviral drugs have been introduced in nearly 3 decades, much effort has focused on learning how to better use acyclovir and how to use existing databases to establish earlier diagnosis.

Investigations of the Effects of Synthetic Chemicals on the Endocrine System of Common Carp in Lake Mead, Nevada and Arizona

USGS Publications Warehouse

Rosen, Michael R.; Goodbred, Steven L.; Patiño, Reynaldo; Leiker, Thomas A.; Orsak, Erik

2006-01-01

Introduction: Lake Mead is the largest reservoir by volume in the United States and was created by the construction of the 221-meter high Hoover Dam in 1935 at Black Canyon on the lower Colorado River between Nevada and Arizona (fig. 1). Inflows of water into the lake include three rivers, Colorado, Virgin, and Muddy; as well as Las Vegas Wash, which is now perennial because of discharges from municipal wastewater treatment plants (Covay and Leiker, 1998) and urban stormwater runoff. As the population within the Las Vegas Valley began to increase in the 1940s, the treated effluent volume also has increased and in 1993 it constituted about 96 percent of the annual discharge of Las Vegas Wash (Bevans and others, 1996). The mean flow of Las Vegas Wash into Las Vegas Bay from 1992 to 1998 was about 490,000 m3/d (Preissler and others, 1999) and in 2001 increased to 606,000 m3/d (U.S. Bureau of Reclamation, 2001). The nutrient concentration in most areas of the lake is low, but wastewater discharged into Las Vegas Bay has caused an increased level of nutrients and primary productivity (aquatic plant and algal production) in this area of the lake (LaBounty and Horn, 1997). A byproduct of this increase in productivity has been the establishment of an important recreational fishery in Las Vegas Bay. However, concentrations of chlorophyll a (a measure of algal biomass) have also increased (LaBounty and Horn, 1997). In the spring of 2001, parts of Lake Mead experienced massive algal blooms. In addition to nutrient loading by wastewater, the presence of numerous synthetic chemicals in water, bottom sediments, and in fish tissue also has been reported (Bevans and others, 1996). Synthetic chemicals discharging into Las Vegas Bay and Lake Mead (fig. 1) originate from several sources that include surplus residential-irrigation water runoff, stormwater runoff, subsurface inflow, and tertiary treated sewage effluent discharging from three sewage-treatment plants. Chemicals detected in Las Vegas Wash and Bay environments include polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), organochlorine pesticides (including DDT and DDE), and 'emerging contaminants' such as fragrances/musks, flame retardants, triclosan and its breakdown products, personal care products, and pharmaceuticals (Bevans and others, 1996; Boyd and Furlong, 2002; Leiker and others, in press). Many of these compounds are able to interact with the endocrine system of animals and potentially cause reproductive impacts. The National Park Service (NPS) manages Lake Mead National Recreation Area (LMNRA) with about 8 million yearly visitors including 500,000 anglers drawn to its world-class recreational fishery. The U.S. Fish and Wildlife Service (FWS) provides management for the federally designated, endangered razorback sucker (Xyrauchen texanus) and for more than 180 species of migratory birds that utilize LMNRA surface waters. These multiple uses of surface water in the area demonstrate their vital importance to the LMNRA as well as the need to maintain the quality of water at levels that are adequate for these uses.

Pequeños telescopios ópticos para fotometria diferencial

NASA Astrophysics Data System (ADS)

Mauas, P.; Schwartz, M.; Perna, P.

We present the Telescopes Horacio Ghielmetti (THG) and Magnetic Activity and Transiting Exoplanets (MATE); located at the CASLEO and OAFA; both in El Leoncito. These are two Meade telescopes of 16''; completely authomatic; specially suited for differential photometry. FULL TEXT IN SPANISH

Development.

ERIC Educational Resources Information Center

Boydell, Tom

1982-01-01

Explores the theories and models of self-actualization and human development. Twelve tables illustrate developmental stages, ways of knowing, moral and ethical development, management style, goals of learning, organizational development, and other dimensions. Availability: M.E.A.D. Subscriptions, C.S.M.L., University of Lancaster, Lancaster LA1…

14. Interior view of vestibule separating rehabilitation space, testing room, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. Interior view of vestibule separating rehabilitation space, testing room, and corridor to workout room looking into corridor; near center of occupied portion; view to southeast. - Ellsworth Air Force Base, Mess & Administration Building, 2279 Risner Drive, Blackhawk, Meade County, SD

9. Interior view of unoccupied space; showing opened exterior garage ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. Interior view of unoccupied space; showing opened exterior garage door, opened doorway to adjoining rooms, and closed exterior doorway; near southeast corner of building; view to southwest. - Ellsworth Air Force Base, Warehouse, 789 Twining Street, Blackhawk, Meade County, SD

Multipass Target Search in Natural Environments

PubMed Central

Otte, Michael W.; Sofge, Donald; Gupta, Satyandra K.

2017-01-01

Consider a disaster scenario where search and rescue workers must search difficult to access buildings during an earthquake or flood. Often, finding survivors a few hours sooner results in a dramatic increase in saved lives, suggesting the use of drones for expedient rescue operations. Entropy can be used to quantify the generation and resolution of uncertainty. When searching for targets, maximizing mutual information of future sensor observations will minimize expected target location uncertainty by minimizing the entropy of the future estimate. Motion planning for multi-target autonomous search requires planning over an area with an imperfect sensor and may require multiple passes, which is hindered by the submodularity property of mutual information. Further, mission duration constraints must be handled accordingly, requiring consideration of the vehicle’s dynamics to generate feasible trajectories and must plan trajectories spanning the entire mission duration, something which most information gathering algorithms are incapable of doing. If unanticipated changes occur in an uncertain environment, new plans must be generated quickly. In addition, planning multipass trajectories requires evaluating path dependent rewards, requiring planning in the space of all previously selected actions, compounding the problem. We present an anytime algorithm for autonomous multipass target search in natural environments. The algorithm is capable of generating long duration dynamically feasible multipass coverage plans that maximize mutual information using a variety of techniques such as ϵ-admissible heuristics to speed up the search. To the authors’ knowledge this is the first attempt at efficiently solving multipass target search problems of such long duration. The proposed algorithm is based on best first branch and bound and is benchmarked against state of the art algorithms adapted to the problem in natural Simplex environments, gathering the most information in the given search time. PMID:29099087

Recurrent lumbosacral herpes simplex virus infection

PubMed Central

Vassantachart, Janna M.

2016-01-01

We present the case of a 54-year-old white woman with episodic lumbosacral lesions that she had been treating as psoriasis. Evaluation revealed classic herpes simplex virus (HSV) infection. The discussion reviews the significance and potential complications of recurrent lumbosacral HSV infection. PMID:26722168

Stress field rotation or block rotation: An example from the Lake Mead fault system

NASA Technical Reports Server (NTRS)

Ron, Hagai; Nur, Amos; Aydin, Atilla

1990-01-01

The Coulomb criterion, as applied by Anderson (1951), has been widely used as the basis for inferring paleostresses from in situ fault slip data, assuming that faults are optimally oriented relative to the tectonic stress direction. Consequently if stress direction is fixed during deformation so must be the faults. Freund (1974) has shown that faults, when arranged in sets, must generally rotate as they slip. Nur et al., (1986) showed how sufficiently large rotations require the development of new sets of faults which are more favorably oriented to the principal direction of stress. This leads to the appearance of multiple fault sets in which older faults are offset by younger ones, both having the same sense of slip. Consequently correct paleostress analysis must include the possible effect of fault and material rotation, in addition to stress field rotation. The combined effects of stress field rotation and material rotation were investigated in the Lake Meade Fault System (LMFS) especially in the Hoover Dam area. Fault inversion results imply an apparent 60 degrees clockwise (CW) rotation of the stress field since mid-Miocene time. In contrast structural data from the rest of the Great Basin suggest only a 30 degrees CW stress field rotation. By incorporating paleomagnetic and seismic evidence, the 30 degrees discrepancy can be neatly resolved. Based on paleomagnetic declination anomalies, it is inferred that slip on NW trending right lateral faults caused a local 30 degrees counter-clockwise (CCW) rotation of blocks and faults in the Lake Mead area. Consequently the inferred 60 degrees CW rotation of the stress field in the LMFS consists of an actual 30 degrees CW rotation of the stress field (as for the entire Great Basin) plus a local 30 degrees CCW material rotation of the LMFS fault blocks.

Developing the remote sensing-based early warning system for monitoring TSS concentrations in Lake Mead.

PubMed

Imen, Sanaz; Chang, Ni-Bin; Yang, Y Jeffrey

2015-09-01

Adjustment of the water treatment process to changes in water quality is a focus area for engineers and managers of water treatment plants. The desired and preferred capability depends on timely and quantitative knowledge of water quality monitoring in terms of total suspended solids (TSS) concentrations. This paper presents the development of a suite of nowcasting and forecasting methods by using high-resolution remote-sensing-based monitoring techniques on a daily basis. First, the integrated data fusion and mining (IDFM) technique was applied to develop a near real-time monitoring system for daily nowcasting of the TSS concentrations. Then a nonlinear autoregressive neural network with external input (NARXNET) model was selected and applied for forecasting analysis of the changes in TSS concentrations over time on a rolling basis onward using the IDFM technique. The implementation of such an integrated forecasting and nowcasting approach was assessed by a case study at Lake Mead hosting the water intake for Las Vegas, Nevada, in the water-stressed western U.S. Long-term monthly averaged results showed no simultaneous impact from forest fire events on accelerating the rise of TSS concentration. However, the results showed a probable impact of a decade of drought on increasing TSS concentration in the Colorado River Arm and Overton Arm. Results of the forecasting model highlight the reservoir water level as a significant parameter in predicting TSS in Lake Mead. In addition, the R-squared value of 0.98 and the root mean square error of 0.5 between the observed and predicted TSS values demonstrates the reliability and application potential of this remote sensing-based early warning system in terms of TSS projections at a drinking water intake. Copyright © 2015 Elsevier Ltd. All rights reserved.

Algae-mediated removal of selected pharmaceutical and personal care products (PPCPs) from Lake Mead water.

PubMed

Bai, Xuelian; Acharya, Kumud

2017-03-01

The persistence and fate of pharmaceutical and personal care products (PPCPs) in the Lake Mead ecosystem are particularly important considering the potential ecological risks and human health impacts. This study evaluated the removal of five common PPCPs (i.e., trimethoprim, sulfamethoxazole, carbamazepine, ciprofloxacin, and triclosan) from Lake Mead water mediated by the green alga Nannochloris sp. The results from the incubation studies showed that trimethoprim and carbamazepine were highly resistant to uptake in the algal cultural medium and were measured at approximately 90%-100% of the applied dose after 14days of incubation. Sulfamethoxazole was found relatively persistent, with >60% of the applied dose remaining in the water after 14days, and its removal was mainly caused by algae-mediated photolysis. However, ciprofloxacin and triclosan dissipated significantly and nearly 100% of the compounds were removed from the water after 7days of incubation under 24h of light. Ciprofloxacin and triclosan were highly susceptible to light, and their estimated half-lives were 12.7hours for ciprofloxacin and 31.2hours for triclosan. Algae-mediated sorption contributed to 11% of the removal of trimethoprim and sulfamethoxazole, 13% of the removal of carbamazepine, and 27% of the removal of triclosan from the lake water. This research showed that 1) trimethoprim, sulfamethoxazole, and carbamazepine are quite persistent in aquatic environments and may potentially affect human health via drinking water intake; 2) photolysis is the dominant pathway to remove ciprofloxacin from aquatic ecosystems, which indicates that ciprofloxacin may have lower ecological risks compared with other PPCPs; and 3) triclosan can undergo photolysis as well as algae-mediated uptake and it may potentially affect the food web because of its high toxicity to aquatic species. Copyright © 2017 Elsevier B.V. All rights reserved.

Stress field rotation or block rotation: An example from the Lake Mead fault system

NASA Astrophysics Data System (ADS)

Ron, Hagai; Nur, Amos; Aydin, Atilla

1990-02-01

The Coulomb criterion, as applied by Anderson (1951), has been widely used as the basis for inferring paleostresses from in situ fault slip data, assuming that faults are optimally oriented relative to the tectonic stress direction. Consequently if stress direction is fixed during deformation so must be the faults. Freund (1974) has shown that faults, when arranged in sets, must generally rotate as they slip. Nur et al., (1986) showed how sufficiently large rotations require the development of new sets of faults which are more favorably oriented to the principal direction of stress. This leads to the appearance of multiple fault sets in which older faults are offset by younger ones, both having the same sense of slip. Consequently correct paleostress analysis must include the possible effect of fault and material rotation, in addition to stress field rotation. The combined effects of stress field rotation and material rotation were investigated in the Lake Meade Fault System (LMFS) especially in the Hoover Dam area. Fault inversion results imply an apparent 60 degrees clockwise (CW) rotation of the stress field since mid-Miocene time. In contrast structural data from the rest of the Great Basin suggest only a 30 degrees CW stress field rotation. By incorporating paleomagnetic and seismic evidence, the 30 degrees discrepancy can be neatly resolved. Based on paleomagnetic declination anomalies, it is inferred that slip on NW trending right lateral faults caused a local 30 degrees counter-clockwise (CCW) rotation of blocks and faults in the Lake Mead area. Consequently the inferred 60 degrees CW rotation of the stress field in the LMFS consists of an actual 30 degrees CW rotation of the stress field (as for the entire Great Basin) plus a local 30 degrees CCW material rotation of the LMFS fault blocks.

Physiographic rim of the Grand Canyon, Arizona: a digital database

USGS Publications Warehouse

Billingsley, George H.; Hampton, Haydee M.

1999-01-01

This Open-File report is a digital physiographic map database. This pamphlet serves to introduce and describe the digital data. There is no paper map included in the Open-File report. The report does include, however, PostScript and PDF format plot files, each containing an image of the map. For those interested in a paper plot of information contained in the database or in obtaining the PostScript plot files, please see the section entitled "For Those Who Don't Use Digital Geologic Map Databases" below. This physiographic map of the Grand Canyon is modified from previous versions by Billingsley and Hendricks (1989), and Billingsley and others (1997). The boundary is drawn approximately along the topographic rim of the Grand Canyon and its tributary canyons between Lees Ferry and Lake Mead (shown in red). Several isolated small mesas, buttes, and plateaus are within this area, which overall encompasses about 2,600 square miles. The Grand Canyon lies within the southwestern part of the Colorado Plateaus of northern Arizona between Lees Ferry, Colorado River Mile 0, and Lake Mead, Colorado River Mile 277. The Colorado River is the corridor for raft trips through the Grand Canyon. Limestone rocks of the Kaibab Formation form most of the north and south rims of the Grand Canyon, and a few volcanic rocks form the north rim of parts of the Uinkaret and Shivwits Plateaus. Limestones of the Redwall Limestone and lower Supai Group form the rim of the Hualapai Plateau area, and Limestones of Devonian and Cambrian age form the boundary rim near the mouth of Grand Canyon at the Lake Mead. The natural physiographic boundary of the Grand Canyon is roughly the area a visitor would first view any part of the Grand Canyon and its tributaries.

The Project Manager Who Saved His Country

NASA Technical Reports Server (NTRS)

Baniszewski, John

2008-01-01

George Meade defeated Robert E. Lee, one of the greatest military leaders of all time. How did he do it? By using the skills he had learned as a project manager and outperforming Lee in all aspects of project management. Most project managers are familiar with the Project Management Institute's "Guide to the Project Management Body of Knowledge" (PMBOK), which identifies the skills and knowledge crucial to successful project management. Project managers need to make sure that all the elements of a project work together. They must develop and execute plans and coordinate changes to those plans. A project manager must define the scope of the work, break it into manageable pieces, verify and control what work is being done, and make sure that the work being done is essential to the project. Every project manager knows the challenges of schedule and the value of schedule slack. Project managers must get the resources they need and use them effectively. Project managers get the people they need and use their talents to achieve mission success. Projects generate huge amounts of information. A key to project success is getting sufficient and accurate information to the people who need it when they need it. Project managers must identify and quantify the risks that jeopardize project success and make plans for dealing with them. Studying Meade and Lee's performances at Gettysburg can help modern project managers appreciate, develop, and use the skills they need to be good project managers. The circumstances may be different, but the basic principles are the same. This dramatic event in American history shows how the skills of project management can be used in almost any situation. Former project manager George Meade used those skills to change the tide of the Civil War.

NFκB-mediated activation of the cellular FUT3, 5 and 6 gene cluster by herpes simplex virus type 1.

PubMed

Nordén, Rickard; Samuelsson, Ebba; Nyström, Kristina

2017-11-01

Herpes simplex virus type 1 has the ability to induce expression of a human gene cluster located on chromosome 19 upon infection. This gene cluster contains three fucosyltransferases (encoded by FUT3, FUT5 and FUT6) with the ability to add a fucose to an N-acetylglucosamine residue. Little is known regarding the transcriptional activation of these three genes in human cells. Intriguingly, herpes simplex virus type 1 activates all three genes simultaneously during infection, a situation not observed in uninfected tissue, pointing towards a virus specific mechanism for transcriptional activation. The aim of this study was to define the underlying mechanism for the herpes simplex virus type 1 activation of FUT3, FUT5 and FUT6 transcription. The transcriptional activation of the FUT-gene cluster on chromosome 19 in fibroblasts was specific, not involving adjacent genes. Moreover, inhibition of NFκB signaling through panepoxydone treatment significantly decreased the induction of FUT3, FUT5 and FUT6 transcriptional activation, as did siRNA targeting of p65, in herpes simplex virus type 1 infected fibroblasts. NFκB and p65 signaling appears to play an important role in the regulation of FUT3, FUT5 and FUT6 transcriptional activation by herpes simplex virus type 1 although additional, unidentified, viral factors might account for part of the mechanism as direct interferon mediated stimulation of NFκB was not sufficient to induce the fucosyltransferase encoding gene cluster in uninfected cells. © The Author 2017. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Parasite diversity of Nyctiphanes simplex and Nematoscelis difficilis (Crustacea: Euphausiacea) along the northwestern coast of Mexico.

PubMed

Gómez-Gutiérrez, Jaime; Robinson, Carlos J; Kawaguchi, So; Nicol, Stephen

2010-02-17

The diversity of parasites found on Nyctiphanes simplex and Nematoscelis difficilis (Order Euphausiacea) was compared during 10 oceanographic cruises made off both coasts of the Baja California peninsula, Mexico. We tested the hypothesis that N. simplex has a more diverse parasitic assemblage than N. difficilis because it is a neritic species, has larger population abundance, and tends to form denser and more compact swarms than N. difficilis. These biological and behavioral features may enhance parasite transmission within swarms. We detected 6 types of ectoparasites: (1) epibiotic diatoms Licmophora sp.; (2) Ephelotidae suctorian ciliates; (3) Foettingeriidae exuviotrophic apostome ciliates; (4) an unidentified epicaridean cryptoniscus larvae (isopoda); and 2 castrators: (5) the ectoparasitic Dajidae isopod Notophryxus lateralis and (6) the ellobiopsid mesoparasite Thalassomyces fagei. We also detected 7 types of endoparasites: (1) an undescribed Collinia ciliate (Apostomatida); 3 types of Cestoda: (2) a Tetrarhynchobothruium sp. (Trypanorhyncha), (3) Echinobothrium sp. (Diphyllidea: Echinobothyriidae), and (4) unidentified metacestode; (5) a Trematoda Paronatrema-like metacercaria (Syncoeliidae); (6) the nematode Anisakis simplex (L3); and (7) Polymorphidae acantocephalan larvae (acanthor, acanthella, and cystacanth larval stages). N. simplex is affected by all types of parasites, except the isopod N. lateralis, having a considerably larger parasitic diversity and prevalence rates than N. difficilis, which is only infested with 3 types of ectoparasites and T. fagei. Euphausiid swarming is an adaptive behavior for reproduction, protection against predators, and increased efficiency in food searching, but has a negative effect due to parasitism. Although the advantages of aggregation must overcome the reduction of population and individual fitness induced by parasites, we demonstrated that all types of parasites can affect approximately 14% of N. simplex individuals. Collinia spp. endoparasitoids must occasionally have a significant influence on population mortality with potential epizootic events.

Computational benefits using artificial intelligent methodologies for the solution of an environmental design problem: saltwater intrusion.

PubMed

Papadopoulou, Maria P; Nikolos, Ioannis K; Karatzas, George P

2010-01-01

Artificial Neural Networks (ANNs) comprise a powerful tool to approximate the complicated behavior and response of physical systems allowing considerable reduction in computation time during time-consuming optimization runs. In this work, a Radial Basis Function Artificial Neural Network (RBFN) is combined with a Differential Evolution (DE) algorithm to solve a water resources management problem, using an optimization procedure. The objective of the optimization scheme is to cover the daily water demand on the coastal aquifer east of the city of Heraklion, Crete, without reducing the subsurface water quality due to seawater intrusion. The RBFN is utilized as an on-line surrogate model to approximate the behavior of the aquifer and to replace some of the costly evaluations of an accurate numerical simulation model which solves the subsurface water flow differential equations. The RBFN is used as a local approximation model in such a way as to maintain the robustness of the DE algorithm. The results of this procedure are compared to the corresponding results obtained by using the Simplex method and by using the DE procedure without the surrogate model. As it is demonstrated, the use of the surrogate model accelerates the convergence of the DE optimization procedure and additionally provides a better solution at the same number of exact evaluations, compared to the original DE algorithm.

Imaging 2D structures by the CSAMT method: application to the Pantano di S. Gregorio Magno faulted basin (Southern Italy)

NASA Astrophysics Data System (ADS)

Troiano, Antonio; Di Giuseppe, Maria Giulia; Petrillo, Zaccaria; Patella, Domenico

2009-06-01

A controlled source audiofrequency magnetotelluric (CSAMT) survey has been undertaken in the Pantano di San Gregorio Magno faulted basin, an earthquake prone area of Southern Apennines in Italy. A dataset from 11 soundings, distributed along a nearly N-S 780 m long profile, was acquired in the basin's easternmost area, where the fewest data are available as to the faulting shallow features. A preliminary skew analysis allowed a prevailing 2D nature of the dataset to be ascertained. Then, using a single-site multi-frequency approach, Dantzig's simplex algorithm was introduced for the first time to estimate the CSAMT decomposition parameters. The simplex algorithm, freely available online, proved to be fast and efficient. By this approach, the TM and TE mode field diagrams were obtained and a N35°W ± 10° 2D strike mean direction was estimated along the profile, in substantial agreement with the fault traces within the basin. A 2D inversion of the apparent resistivity and phase curves at seven almost noise-free sites distributed along the central portion of the profile was finally elaborated, reinforced by a sensitivity analysis, which allowed the best resolved portion of the model to be imaged from the first few meters of depth down to a mean depth of 300 m b.g.l. From the inverted section, the following features have been outlined: (i) a cover layer with resistivity in the range 3-30 Ω m ascribed to the Quaternary lacustrine clayey deposits filling the basin, down to an average depth of about 35 m b.g.l., underlain by a structure with resistivity over 50 Ω m up to about 600 Ω m, ascribed to the Mesozoic carbonate bedrock; (ii) a system of two normal faults within the carbonate basement, extending down to the maximum best resolved depth of the order of 300 m b.g.l.; (iii) two wedge-shaped domains separating the opposite blocks of the faults with resistivity ranging between 30 Ω m and 50 Ω m and horizontal extent of the order of some tens of metres, likely filled with lacustrine sediments and embedded fine gravels.

The "Other" Venereal Diseases: Herpes Simplex, Trichomoniasis and Candidiasis.

ERIC Educational Resources Information Center

McNab, Warren L.

1979-01-01

Although the term venereal disease has been synonymous with gonorrhea and syphilis, the Center for Disease Control now states that the number of new cases of herpes simplex, trichomoniasis, and candidiasis is rapidly approaching the number of cases of syphilis and gonorrhea. (MM)

The Longitudinal Guttman Simplex: Applications to Health Behavior Data.

ERIC Educational Resources Information Center

Collins, Linda M.; Dent, Clyde W.

Because health behavior is often concerned with dynamic constructs, a longitudinal approach to measurement is needed. The Longitudinal Guttman Simplex (LGS) is a measurement model developed especially for dynamic constructs exhibiting cumulative, unitary development measured longitudinally. Data from the Television Smoking Prevention Project, a…

Immunity to herpes simplex virus type 2. Suppression of virus-induced immune responses in ultraviolet B-irradiated mice

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yasumoto, S.; Hayashi, Y.; Aurelian, L.

1987-10-15

Ultraviolet B irradiation (280 to 320 nm) of mice at the site of intradermal infection with herpes simplex virus type 2 increased the severity of the herpes simplex virus type 2 disease and decreased delayed-type hypersensitivity (DTH) responses to viral antigen. Decrease in DTH resulted from the induction of suppressor T cells, as evidenced by the ability of spleen cells from UV-irradiated mice to inhibit DTH and proliferative responses after adoptive transfer. Lymph node cells from UV-irradiated animals did not transfer suppression. DTH was suppressed at the induction but not the expression phase. Suppressor T cells were Lyt-1+, L3T4+, andmore » their activity was antigen-specific. However, after in vitro culture of spleen cells from UV-irradiated mice with herpes simplex virus type 2 antigen, suppressor activity was mediated by Lyt-2+ cells. Culture supernatants contained soluble nonantigen-specific suppressive factors.« less

Expression of Genes Encoding the Enzymes for Glycogen and Trehalose Metabolism in L3 and L4 Larvae of Anisakis simplex.

PubMed

Łopieńska-Biernat, E; Zaobidna, E A; Dmitryjuk, M

2015-01-01

Trehalose and glycogen metabolism plays an important role in supporting life processes in many nematodes, including Anisakis simplex. Nematodes, cosmopolitan helminths parasitizing sea mammals and humans, cause a disease known as anisakiasis. The aim of this study was to investigate the expression of genes encoding the enzymes involved in the metabolism of trehalose and glycogen-trehalose-6-phosphate synthase (TPS), trehalose-6-phosphate phosphatase (TPP), glycogen synthase (GS), and glycogen phosphorylase (GP)-in stage L3 and stage L4 larvae of A. simplex. The expression of mRNA all four genes, tps, tpp, gs, and gp, was examined by real-time polymerase chain reaction. The A. simplex ribosomal gene (18S) was used as a reference gene. Enzymatic activity was determined. The expression of trehalose enzyme genes was higher in L3 than in L4 larvae, but an inverse relationship was noted for the expression of gs and gp genes.

Expression of Genes Encoding the Enzymes for Glycogen and Trehalose Metabolism in L3 and L4 Larvae of Anisakis simplex

PubMed Central

Łopieńska-Biernat, E.; Zaobidna, E. A.; Dmitryjuk, M.

2015-01-01

Trehalose and glycogen metabolism plays an important role in supporting life processes in many nematodes, including Anisakis simplex. Nematodes, cosmopolitan helminths parasitizing sea mammals and humans, cause a disease known as anisakiasis. The aim of this study was to investigate the expression of genes encoding the enzymes involved in the metabolism of trehalose and glycogen—trehalose-6-phosphate synthase (TPS), trehalose-6-phosphate phosphatase (TPP), glycogen synthase (GS), and glycogen phosphorylase (GP)—in stage L3 and stage L4 larvae of A. simplex. The expression of mRNA all four genes, tps, tpp, gs, and gp, was examined by real-time polymerase chain reaction. The A. simplex ribosomal gene (18S) was used as a reference gene. Enzymatic activity was determined. The expression of trehalose enzyme genes was higher in L3 than in L4 larvae, but an inverse relationship was noted for the expression of gs and gp genes. PMID:26783451

Construction of Poxviruses as Cloning Vectors: Insertion of the Thymidine Kinase Gene from Herpes Simplex Virus into the DNA of Infectious Vaccinia Virus

NASA Astrophysics Data System (ADS)

Panicali, Dennis; Paoletti, Enzo

1982-08-01

We have constructed recombinant vaccinia viruses containing the thymidine kinase gene from herpes simplex virus. The gene was inserted into the genome of a variant of vaccinia virus that had undergone spontaneous deletion as well as into the 120-megadalton genome of the large prototypic vaccinia variant. This was accomplished via in vivo recombination by contransfection of eukaryotic tissue culture cells with cloned BamHI-digested thymidine kinase gene from herpes simplex virus containing flanking vaccinia virus DNA sequences and infectious rescuing vaccinia virus. Pure populations of the recombinant viruses were obtained by replica filter techniques or by growth of the recombinant virus in biochemically selective medium. The herpes simplex virus thymidine kinase gene, as an insert in vaccinia virus, is transcribed in vivo and in vitro, and the fidelity of in vivo transcription into a functional gene product was detected by the phosphorylation of 5-[125I]iodo-2'-deoxycytidine.

77 FR 56625 - Privacy Act of 1974; Systems of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-13

... Internet at http://www.regulations.gov as they are received without change, including any personal.... George G. Meade, MD 20755-6000. Decentralized segments: Defense Intelligence Agency (DIA) Headquarters... decentralized system locations, write to the National Security Agency/Central Security Service, Freedom of...

6. Interior view of main entrance vestibule looking towards lobby; ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. Interior view of main entrance vestibule looking towards lobby; showing wall mounted information stations and drinking fountain; near southeast corner of building on main floor; view to north. - Ellsworth Air Force Base, Mess & Administration Building, 1561 Ellsworth Street, Blackhawk, Meade County, SD

Research Grants Series No. 1.

ERIC Educational Resources Information Center

Queensland Board of Teacher Education, Toowong (Australia).

The Queensland Board of Teacher Education instituted a small grants scheme to encourage research into teacher education. This document contains summaries of four projects. The first, "Admission of Student Teachers Using Both Academic and Non-Academic Criteria" (Phil Meade and David Smith), investigated the performance of teacher…

10. Interior view of open work station area looking from ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. Interior view of open work station area looking from southwest corner of space; showing opened doorway to office with exterior window; center of north wing; view to northeast. - Ellsworth Air Force Base, Administration Office, 2704 George Drive, Blackhawk, Meade County, SD

Career Exploration among College Students

ERIC Educational Resources Information Center

Fouad, Nadya A.; Ghosh, Arpita; Chang, Wen-hsin; Figueiredo, Catia; Bachhuber, Thomas

2016-01-01

College is a significant time for undergraduates to declare majors and choose career paths. For many undergraduates, choosing both a major and a career path is challenging. Research shows that many universities deliver career interventions through dedicated career decision-making courses (Mead & Korschgen, 1994). However, there has been…

78 FR 72093 - South Dakota; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-02

... designated as adversely affected by this major disaster: Butte, Corson, Custer, Dewey, Fall River, Haakon... River Sioux Tribe of the Cheyenne River Reservation within Dewey and Ziebach Counties and the Oglala..., Corson, Custer, Dewey, Fall River, Haakon, Harding, Jackson, Lawrence, Meade, Pennington, Perkins...

Grand Canyon, Lake Powell, and Lake Mead

NASA Technical Reports Server (NTRS)

2002-01-01

A snowfall in the American West provides contrast to the landscape's muted earth tones and indicates changes in topography and elevation across (clockwise from top left) Nevada, Utah, Colorado, New Mexico, Arizona, and California. In Utah, the southern ranges of the Wasatch Mountains are covered in snow, and the Colorado River etches a dark ribbon across the red rock of the Colorado Plateau. In the center of the image is the reservoir created by the Glen Canyon Dam. To the east are the gray-colored slopes of Navaho Mountain, and to the southeast, dusted with snow is the region called Black Mesa. Southwest of Glen Canyon, the Colorado enters the Grand Canyon, which cuts westward through Arizona. At a deep bend in the river, the higher elevations of the Keibab Plateau have held onto snow. At the end of the Grand Canyon lies another large reservoir, Lake Mead, which is formed by the Hoover Dam. Credit: Jacques Descloitres, MODIS Land Rapid Response Team, NASA/GSFC

Development of an Accelerated Test Design for Predicting the Service Life of the Solar Array at Mead, Nebraska

NASA Technical Reports Server (NTRS)

Gaines, G. B.; Thomas, R. E.; Noel, G. T.; Shilliday, T. S.; Wood, V. E.; Carmichael, D. C.

1979-01-01

An accelerated life test is described which was developed to predict the life of the 25 kW photovoltaic array installed near Mead, Nebraska. A quantitative model for accelerating testing using multiple environmental stresses was used to develop the test design. The model accounts for the effects of thermal stress by a relation of the Arrhenius form. This relation was then corrected for the effects of nonthermal environmental stresses, such as relative humidity, atmospheric pollutants, and ultraviolet radiation. The correction factors for the nonthermal stresses included temperature-dependent exponents to account for the effects of interactions between thermal and nonthermal stresses on the rate of degradation of power output. The test conditions, measurements, and data analyses for the accelerated tests are presented. Constant-temperature, cyclic-temperature, and UV types of tests are specified, incorporating selected levels of relative humidity and chemical contamination and an imposed forward-bias current and static electric field.

Radionuclide imaging in herpes simplex encephalitis. [/sup 99m/Tc tracer techniques

DOE Office of Scientific and Technical Information (OSTI.GOV)

Karlin, C.A.; Robinson, R.G.; Hinthorn, D.R.

1978-01-01

Eight patients with herpes simplex encephalitis among the 10 cases diagnosed at the University of Kansas Medical Center from 1966 to 1976 were studied with /sup 99m/Tc early in their diagnostic work-up. The images were unilaterally positive in the temporal lobe area in all 8 patients. Radionuclide studies can suggest herpes simplex as the specific etiology in cases of encephalitis and can also indicate the best site for brain biopsy to confirm the diagnosis by fluorescent antibody techniques. Appropriate antiviral therapy should be instituted as soon as possible to alter the course of this destructive form of viral encephalitis.

Herpes Simplex Encephalitis Complicated by Cerebral Hemorrhage during Acyclovir Therapy.

PubMed

Harada, Yukinori; Hara, Yuuta

2017-01-01

Herpes simplex encephalitis (HSE) can be complicated by adverse events in the acute phase. We herein present the case of a 71-year-old woman with HSE complicated by cerebral hemorrhage. She presented with acute deterioration of consciousness and fever and was diagnosed with HSE based on the detection of herpes simplex virus-1 in the cerebrospinal fluid by a polymerase chain reaction. The cerebral hemorrhage developed during acyclovir therapy; however, its diagnosis was delayed for 2 days. After the conservative treatment of the cerebral hemorrhage, the patient made a near-complete recovery. Cerebral hemorrhage should be considered as an acute-phase complication of HSE.

Helicase-primase inhibitors for herpes simplex virus: looking to the future of non-nucleoside inhibitors for treating herpes virus infections.

PubMed

Biswas, Subhajit; Sukla, Soumi; Field, Hugh J

2014-01-01

Helicase-primase inhibitors (HPIs) are the first new family of potent herpes virus (herpes simplex and varicella-zoster virus) inhibitors to go beyond the preliminary stages of investigation since the emergence of the original nucleoside analog inhibitors. To consider the clinical future of HPIs, this review puts the exciting new findings with two HPIs, amenamevir and pritelivir, into the historical context of antiviral development for the prevention and treatment of herpes simplex virus over the last century and, on this basis, the authors speculate on the potential evolution of these and other non-nucleoside inhibitors in the future.

Principles and Concepts for Information and Communication Technology Design.

ERIC Educational Resources Information Center

Adams, Ray; Langdon, Patrick

2003-01-01

This article presents a theory for evaluating information and communication technology design for individuals with disabilities. Simplex 1 evaluates designs in five zones: sensory and input zone; output zone; abstract working memory; long-term memory; and central executive functioning. Simplex 2 evaluates feedback, emotional responses, cognitive…

Argument Structure of Tsou: Simplex and Complex Predicates

ERIC Educational Resources Information Center

Lin, Gujing

2010-01-01

This thesis investigates the argument structure of Tsou, a Formosan language within the Austronesian family. The investigation studies both simplex and complex predicates as well as describes the valency groupings and alignment patterns emerging from various clausal configurations. Assuming the stance that language description should respect…

Molecular requirement for sterols in herpes simplex virus entry and infectivity

USDA-ARS?s Scientific Manuscript database

Herpes simplex virus 1 (HSV-1) required cholesterol for virion-induced membrane fusion. HSV successfully entered DHCR24-/-cells, which lack a desmosterol-to-cholesterol conversion enzyme, indicating entry can occur independently of cholesterol. Depletion of desmosterol from these cells resulted in d...

RESEARCH PROGRAM FOR ALERTING, DETECTION AND IDENTIFICATION OF PATHOGENES.

DTIC Science & Technology

characteristic products. BHK-21 and RK-13 tissue cultures infected with NDV, influenza, YFV , Sendai, Vaccinia, and Herpes simplex showed a depletion of...infected and control serum could be detected in mice infected with YFV , influenza, Herpes simplex, and LDV superinfected with YFV . Several methods of

40 CFR 81.318 - Kentucky.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Madison Co. in Richmond X Rest of Madison Co X Magoffin County X Marion County X Marshall County X Martin... X Magoffin County X Marion County X Marshall County X Martin County X Mason County X Meade County X... Marshall County Unclassifiable/Attainment Martin County Unclassifiable/Attainment Mason County...

40 CFR 80.215 - What is the scope of the geographic phase-in program?

Code of Federal Regulations, 2014 CFR

2014-07-01

... River Haakon Harding Jackson Jones Lawrence Meade Mellette Pennington Perkins Shannon Stanley Todd... Indian reservations follows: Burns Paiute, Cheyenne River, Colville, Duck Valley, Ely Colony, Fort Apache, Fort McDermitt, Goshute, Haulapai, Havasupai, Hopi, Kalispel, Navajo, Pine Ridge, Rosebud, Yakama, San...

40 CFR 80.215 - What is the scope of the geographic phase-in program?

Code of Federal Regulations, 2012 CFR

2012-07-01

... River Haakon Harding Jackson Jones Lawrence Meade Mellette Pennington Perkins Shannon Stanley Todd... Indian reservations follows: Burns Paiute, Cheyenne River, Colville, Duck Valley, Ely Colony, Fort Apache, Fort McDermitt, Goshute, Haulapai, Havasupai, Hopi, Kalispel, Navajo, Pine Ridge, Rosebud, Yakama, San...

40 CFR 80.215 - What is the scope of the geographic phase-in program?

Code of Federal Regulations, 2013 CFR

2013-07-01

... River Haakon Harding Jackson Jones Lawrence Meade Mellette Pennington Perkins Shannon Stanley Todd... Indian reservations follows: Burns Paiute, Cheyenne River, Colville, Duck Valley, Ely Colony, Fort Apache, Fort McDermitt, Goshute, Haulapai, Havasupai, Hopi, Kalispel, Navajo, Pine Ridge, Rosebud, Yakama, San...

The Island Earth

ERIC Educational Resources Information Center

Mead, Margaret

1970-01-01

Dr. Mead, the world-renowned anthropologist and expert behavioral scientist, is associated with the American Museum of Natural History, which acts as her headquarters as she documents her observations on Man, society and technology. She discusses the need to develop specialists with concern for saving the endangered planet earth. (Editor/GR)

A New Look at the Age of Technology

ERIC Educational Resources Information Center

Mead, Margaret

1972-01-01

Dr. Mead received the 1970 Kalinga Prize on 2 December, 1971. The Prize, established in 1951, is awarded annually by Unesco for significant contribution to the interpretation of science as an instrument for improving mankind, enriching the culture of nations and answering human and social problems. (Author)