ARL Statistics, 1999-2000: A Compilation of Statistics from the One Hundred and Twenty-Two Members of the Association of Research Libraries.

ERIC Educational Resources Information Center

Kyrillidou, Martha, Comp.; Young, Mark, Comp.

This is the latest in a series of annual publications that describe collections, staffing, expenditures, and service activities for the 122 member libraries of the Association of Research Libraries (ARL). Of these, 112 are universities libraries; the remaining 10 are public, governmental, and private research libraries. ARL member libraries are…

The Blended Librarian: John D. Shankl Center for Learning Technologies, Penn State Berks Lehigh Valley College

ERIC Educational Resources Information Center

Library Journal, 2005

2005-01-01

Early in his library career, John Shank realized that not only were students choosing Internet resources over library, resources, but Faculty members were, too. Shank is now widely recognized as a librarian who's likely to change that. In his current positions as instructional design librarian at Penn State Berks--Lehigh Valley College and…

Library of Michigan Annual Report, 1997.

ERIC Educational Resources Information Center

Michigan Library, Lansing.

The Library of Michigan is the official state library agency of Michigan. This annual report, covering calendar 1997, provides the following information: names and positions of members of the Board of Trustees and members of the Board of Directors, as well as legislative council and alternate members; the Library mission; accomplishments of the…

Solid-phase synthesis and screening of N-acylated polyamine (NAPA) combinatorial libraries for protein binding.

PubMed

Iera, Jaclyn A; Jenkins, Lisa M Miller; Kajiyama, Hiroshi; Kopp, Jeffrey B; Appella, Daniel H

2010-11-15

Inhibitors for protein-protein interactions are challenging to design, in part due to the unique and complex architectures of each protein's interaction domain. Most approaches to develop inhibitors for these interactions rely on rational design, which requires prior structural knowledge of the target and its ligands. In the absence of structural information, a combinatorial approach may be the best alternative to finding inhibitors of a protein-protein interaction. Current chemical libraries, however, consist mostly of molecules designed to inhibit enzymes. In this manuscript, we report the synthesis and screening of a library based on an N-acylated polyamine (NAPA) scaffold that we designed to have specific molecular features necessary to inhibit protein-protein interactions. Screens of the library identified a member with favorable binding properties to the HIV viral protein R (Vpr), a regulatory protein from HIV, that is involved in numerous interactions with other proteins critical for viral replication. Published by Elsevier Ltd.

ARL Statistics, 2000-01: A Compilation of Statistics from the One Hundred and Twenty-Four Members of the Association of Research Libraries.

ERIC Educational Resources Information Center

Kyrillidou, Martha, Comp.; Young, Mark, Comp.

This document is the latest in a series of annual publications that describe collections, staffing, expenditures, and service activities for the 123 members of the Association of Research Libraries (ARL). Of these, 113 are university libraries; the remaining 10 are public, governmental, and private research libraries. ARL member libraries are the…

A Study of Interlibrary Loan Transactions in the Texas Information Exchange.

ERIC Educational Resources Information Center

Texas Information Exchange, Austin.

A questionnaire was designed and circulated to all member libraries of the Texas Information Exchange to gather data associated with the costs and volume of interlibrary loan activity from September 1, 1975 to February 28, 1976. Forty of the forty-five members of the Exchange participated in the study. In the area of costs, information was…

Cooperative Library Services in Southeast Florida: A Staff Perspective

ERIC Educational Resources Information Center

Hayashi, Maris L.

2005-01-01

This article presents the staff perspective on the advantages of collaboration between a library cooperative in Southeast Florida and one of its member libraries. Collaborative relationships between library cooperatives and member libraries exist primarily to benefit library patrons and community users. Important relationships between cooperatives…

HIV/AIDS Information Resources from the National Library of Medicine-STOP

DOE Office of Scientific and Technical Information (OSTI.GOV)

Templin-Branner, W. and N. Dancy

2010-06-15

The HIV/AIDS Information Resources from the National Library of Medicine training is designed specifically for the UNCFSP HBCU Screening, Testing, Outreach, and Prevention (STOP) HIV/AIDS Program project members to provide valuable health information resources from the National Library of Medicine and other reliable sources to increase awareness of the wealth of treatment information and educational materials that are available on the Internet and to improve prevention and treatment education for their clients. These resources will also meet the needs of community-based organizations

Rethinking the core list of journals for libraries that serve schools and colleges of pharmacy.

PubMed

Beckett, Robert D; Cole, Sabrina W; Rogers, Hannah K; Bickett, Skye; Seeger, Christina; McDaniel, Jennifer A

2014-10-01

The Core List of Journals for Libraries that Serve Schools and Colleges of Pharmacy is a guide for developing and maintaining pharmacy-affiliated library collections. A work group was created to update the list and design a process for updating that will streamline future revisions. Work group members searched the National Library of Medicine catalog for an initial list of journals and then applied inclusion criteria to narrow the list. The work group finalized the fifth edition of the list with 225 diverse publications and produced a sustainable set of criteria for journal inclusion, providing a structured, objective process for future updates.

Rethinking the Core List of Journals for Libraries that Serve Schools and Colleges of Pharmacy

PubMed Central

Beckett, Robert D.; Rogers, Hannah K.; Bickett, Skye; Seeger, Christina; McDaniel, Jennifer A.

2014-01-01

The Core List of Journals for Libraries that Serve Schools and Colleges of Pharmacy is a guide for developing and maintaining pharmacy-affiliated library collections. A work group was created to update the list and design a process for updating that will streamline future revisions. Work group members searched the National Library of Medicine catalog for an initial list of journals and then applied inclusion criteria to narrow the list. The work group finalized the fifth edition of the list with 225 diverse publications and produced a sustainable set of criteria for journal inclusion, providing a structured, objective process for future updates. PMID:25349548

Design, synthesis and selection of DNA-encoded small-molecule libraries.

PubMed

Clark, Matthew A; Acharya, Raksha A; Arico-Muendel, Christopher C; Belyanskaya, Svetlana L; Benjamin, Dennis R; Carlson, Neil R; Centrella, Paolo A; Chiu, Cynthia H; Creaser, Steffen P; Cuozzo, John W; Davie, Christopher P; Ding, Yun; Franklin, G Joseph; Franzen, Kurt D; Gefter, Malcolm L; Hale, Steven P; Hansen, Nils J V; Israel, David I; Jiang, Jinwei; Kavarana, Malcolm J; Kelley, Michael S; Kollmann, Christopher S; Li, Fan; Lind, Kenneth; Mataruse, Sibongile; Medeiros, Patricia F; Messer, Jeffrey A; Myers, Paul; O'Keefe, Heather; Oliff, Matthew C; Rise, Cecil E; Satz, Alexander L; Skinner, Steven R; Svendsen, Jennifer L; Tang, Lujia; van Vloten, Kurt; Wagner, Richard W; Yao, Gang; Zhao, Baoguang; Morgan, Barry A

2009-09-01

Biochemical combinatorial techniques such as phage display, RNA display and oligonucleotide aptamers have proven to be reliable methods for generation of ligands to protein targets. Adapting these techniques to small synthetic molecules has been a long-sought goal. We report the synthesis and interrogation of an 800-million-member DNA-encoded library in which small molecules are covalently attached to an encoding oligonucleotide. The library was assembled by a combination of chemical and enzymatic synthesis, and interrogated by affinity selection. We describe methods for the selection and deconvolution of the chemical display library, and the discovery of inhibitors for two enzymes: Aurora A kinase and p38 MAP kinase.

Measuring Consortium Impact on User Perceptions: OhioLINK and LibQUAL+[TM

ERIC Educational Resources Information Center

Gatten, Jeffrey N.

2004-01-01

What is the impact of an academic library consortium on the perceptions of library services experienced by users of the member institutions' libraries? What is the impact of an academic library consortium on the perceptions of library services experienced by users of the member institutions libraries? In 2002 and 2003, OhioLINK (Ohio's consortium…

ARL Annual Salary Survey, 2000-2001.

ERIC Educational Resources Information Center

Kyrillidou, Martha, Comp.; Wetzel, Karen, Comp.

This document reports the 2000-2001 salary data for all professional staff working in ARL (Association of Research Libraries) libraries. Data for 8,882 professional staff members were reported for the 112 ARL university libraries, including their law and medical libraries (811 staff members reported by 68 medical libraries and 708 staff members…

ARL Annual Salary Survey, 1999-2000.

ERIC Educational Resources Information Center

Kyrillidou, Martha, Comp.; O'Connor, Michael, Comp.

This document reports 1999-2000 salary data for all professional staff working in ARL (Association of Research Libraries) libraries. Data for 8,595 professional staff members were reported for the 111 ARL university libraries, including their law and medical libraries (814 staff members reported by 69 medical libraries and 660 staff members…

ARL Annual Salary Survey, 2002-2003.

ERIC Educational Resources Information Center

Kyrillidou, Martha, Comp.; Young, Mark, Comp.

This document reports the 2001-2002 salary data for all professional staff working in ARL (Association of Research Libraries) libraries. Data for 9,469 professional staff members were reported for the 124 ARL university libraries, including their law and medical libraries (909 staff members reported by 69 medical libraries and 726 staff members…

Electronic Journals in Academic Libraries: A Comparison of ARL and Non-ARL Libraries.

ERIC Educational Resources Information Center

Shemberg, Marian; Grossman, Cheryl

1999-01-01

Describes a survey dealing with academic library provision of electronic journals and other electronic resources that compared ARL (Association of Research Libraries) members to non-ARL members. Highlights include full-text electronic journals; computers in libraries; online public access catalogs; interlibrary loan and electronic reserves; access…

Building synthetic gene circuits from combinatorial libraries: screening and selection strategies.

PubMed

Schaerli, Yolanda; Isalan, Mark

2013-07-01

The promise of wide-ranging biotechnology applications inspires synthetic biologists to design novel genetic circuits. However, building such circuits rationally is still not straightforward and often involves painstaking trial-and-error. Mimicking the process of natural selection can help us to bridge the gap between our incomplete understanding of nature's design rules and our desire to build functional networks. By adopting the powerful method of directed evolution, which is usually applied to protein engineering, functional networks can be obtained through screening or selecting from randomised combinatorial libraries. This review first highlights the practical options to introduce combinatorial diversity into gene circuits and then examines strategies for identifying the potentially rare library members with desired functions, either by screening or selection.

ARL Annual Salary Survey, 2001-02.

ERIC Educational Resources Information Center

Kyrillidou, Martha, Comp.; Young, Mark, Comp.

This document reports the 2001-2002 salary data for all professional staff working in ARL (Association of Research Libraries) libraries. Data for 9,198 professional staff members were reported for the 1,130 ARL university libraries, including their law and medical libraries (859 staff members reported by 69 medical libraries and 724 staff members…

Evaluation of "credit card" libraries for inhibition of HIV-1 gp41 fusogenic core formation.

PubMed

Xu, Yang; Lu, Hong; Kennedy, Jack P; Yan, Xuxia; McAllister, Laura A; Yamamoto, Noboru; Moss, Jason A; Boldt, Grant E; Jiang, Shibo; Janda, Kim D

2006-01-01

Protein-protein interactions are of critical importance in biological systems, and small molecule modulators of such protein recognition and intervention processes are of particular interest. To investigate this area of research, we have synthesized small-molecule libraries that can disrupt a number of biologically relevant protein-protein interactions. These library members are designed upon planar motif, appended with a variety of chemical functions, which we have termed "credit-card" structures. From two of our "credit-card" libraries, a series of molecules were uncovered which act as inhibitors against the HIV-1 gp41 fusogenic 6-helix bundle core formation, viral antigen p24 formation, and cell-cell fusion at low micromolar concentrations. From the high-throughput screening assays we utilized, a selective index (SI) value of 4.2 was uncovered for compound 2261, which bodes well for future structure activity investigations and the design of more potent gp41 inhibitors.

A Virtual Library for Instructional Systems Designers.

ERIC Educational Resources Information Center

Kirk, James J.

During the past three years, the role of the instructional systems designer has taken on greater significance for instructors. This is because many faculty members have been asked to put their entire courses online over the World Wide Web. Instructors are now creating a substantial percentage of the online courses with little or no background in…

Solution-Phase Synthesis of a Tricyclic Pyrrole-2-Carboxamide Discovery Library Applying a Stetter-Paal-Knorr Reaction Sequence

PubMed Central

Iyer, Pravin S.; Fodor, Matthew D.; Coleman, Claire M.; Twining, Leslie A.; Mitasev, Branko

2012-01-01

The solution phase synthesis of a discovery library of 178 tricyclic pyrrole-2-carboxamides was accomplished in nine steps and seven purifications starting with three benzoyl protected amino acid methyl esters. Further diversity was introduced by two glyoxaldehydes and forty-one primary amines. The combination of Pauson-Khand, Stetter and microwave assisted Paal Knorr reactions was applied as a key sequence. The discovery library was designed with the help of QikProp 2.1 and physicochemical data are presented for all pyrroles. Library members were synthesized and purified in parallel and analyzed by LC-MS. Selected compounds were fully characterized. PMID:16677007

Remote Library Access for Pharmacy Preceptors

PubMed Central

Soltis, Denise; Schott, Kathy

2010-01-01

Objective To institute and evaluate the response to a program providing access to electronic library resources for pharmacy preceptors. Design The pharmacy experiential office and the library collaborated using existing programs and technology to provide and market secure remote access for preceptors. Assessment Preceptor participation was tracked in the experiential office, and response to the program was assessed using an online survey instrument that included questions about use of and preference for specific library resources. Three hundred thirty-four adjunct faculty members registered, representing 34% of all preceptors with active e-mail accounts. Conclusion Preceptor participation in the program exceeded expectations. Some minor flaws in the logistics of delivering the service were identified and remedied. PMID:21179247

Library Use and Library Skills of Research Assistants: Pilot Study.

ERIC Educational Resources Information Center

Jacob, Lisa Hall; And Others

This paper presents the results of a pilot study of University of Illinois at Chicago faculty members, their assistants who use the library for them, and the role of the Library of the Health Sciences in that process. The Library of the Health Sciences public services staff members, College of Pharmacy faculty, and their assistants were…

Library Photocopy Operations. SPEC Kit 209.

ERIC Educational Resources Information Center

Almony, Robert A., Jr., Comp.; O'Brien, Francis, Comp.

The kit and flyer examine library photocopy operations, including services, personnel, equipment, and financial management practices by member institutions of the Association of Research Libraries (ARL). To find out about these operations, ARL surveyed its 112 members, and received 93 replies. Forty-nine academic libraries (58%) described their…

High-stringency screening of target-binding partners using a microfluidic device

DOEpatents

Soh, Hyongsok; Lou, Xinhui; Lagally, Eric

2015-12-01

The invention provides a method of screening a library of candidate agents by contacting the library with a target in a reaction mixture under a condition of high stringency, wherein the target includes a tag that responds to a controllable force applied to the tag, and passing the members of the library through a microfluidic device in a manner that exposes the library members to the controllable force, thereby displacing members of the library that are bound to the target relative to their unbound counterparts. Kits and systems for use with the methods of the invention are also provided.

Solution-phase parallel synthesis of hexahydro-1H-isoindolone libraries via tactical combination of Cu-catalyzed three-component coupling and Diels-Alder reactions.

PubMed

Zhang, Lei; Lushington, Gerald H; Neuenswander, Benjamin; Hershberger, John C; Malinakova, Helena C

2008-01-01

Parallel solution-phase synthesis of combinatorial libraries of hexahydro-1 H-isoindolones exploiting a novel "tactical combination" of Cu-catalyzed three-component coupling and Diels-Alder reactions was accomplished. Three distinct libraries consisting of 24 members (library I), 60 members (library II), and 32 members (library III) were constructed. Variation of three substituents on the isoindolone scaffold in library I was exclusively achieved by the choice of the building blocks. In the syntheses of libraries II and III, sublibraries of isoindolone scaffolds were prepared initially in a one-pot/two-step process and were further diversified via Pd-catalyzed Suzuki cross-coupling reaction with boronic acids at two different diversification points. The Lipinski profiles and calculated ADME properties of the compounds are also reported.

Fund Raising in ARL Libraries. Kit 94.

ERIC Educational Resources Information Center

Association of Research Libraries, Washington, DC. Office of Management Studies.

In January 1983 the Association of Research Libraries (ARL) surveyed its members regarding their fund raising programs. A response rate of 85% (95 out of 113 libraries surveyed) was obtained. It was found that 85% of ARL member libraries had been involved in university-wide fund campaigns; that over 75% of the respondents had also conducted…

Health Sciences Library Closings; A Context Sensitive Pilot Study.

PubMed

Schwartz, Diane G; Elkin, Peter L

2017-01-01

A significant number of U.S. health sciences libraries have closed since the mid-1990's. A pilot study was conducted with academic physicians to understand the impact of closing the health sciences library in the teaching hospital with which they were affiliated. A brief survey was designed and distributed to fourteen faculty members with thirteen useable responses received. The study elicited a context-sensitive perspective on the closing of the library with the most noteworthy outcome being the additional time required by attending physicians and trainees to perform the work that previously was performed by library staff. The loss of the expert literature search, instructional services, journal request, and interlibrary loan services had the most significant impact on study participants. Further research is needed to understand the long term consequences of closing hospital-based health sciences library on the education of physicians.

Biosynthesis of the Cyclotide MCoTI-II using an Engineered Intein

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cantor, J; Camarero, J A

2006-08-15

Cyclotides are an emerging family of naturally occurring circular mini-proteins ({approx}30-40 amino acids) characterized by six conserved Cys residues (forming 3 disulfide bridges) that create a topologically unique structure designated as a cyclic cysteine knot (CCK). The cysteine knot motif, which is embedded within the macrocylic backbone, is described as two disulfide bridges that form a ring that is penetrated by the third disulfide bridge. The cyclic backbone and CCK motif together confer cyclotides with a remarkable stability and resistance to proteolytic, chemical, and thermal degradation. Further, cyclotides are functionally diverse and display a wide range of functions including uterotonicmore » activity, trypsin inhibition, cytotoxicity, neurotensin binding, anti-HIV, antimicrobial, and insecticidal activity. Together, these characteristics make cyclotides attractive candidates for both drug design and agricultural applications, both in their native forms and as molecular scaffolds for the incorporation of novel bioactivities. [1] The ability to manipulate production of cyclotides within biological systems is critical for mutagenesis studies, production of grafted products, and the mass production of cyclotides with novel activities. My adviser's hope is to achieve this capability by employing recombinant DNA expression techniques to generate large combinatorial libraries of cyclotides. The advantage in creating a biosynthetic library (containing {approx}10{sup 6}-10{sup 10} members/library vs. chemically based libraries with typical values ranging from {approx}10{sup 3}-10{sup 5} members/library) is that it can be lead to the in vivo application of biological screening and selection methodologies based on a specific clone's ability to affect certain cellular processes.« less

Construction of CRISPR Libraries for Functional Screening.

PubMed

Carstens, Carsten P; Felts, Katherine A; Johns, Sarah E

2018-01-01

Identification of gene function has been aided by the ability to generate targeted gene knockouts or transcriptional repression using the CRISPR/CAS9 system. Using pooled libraries of guide RNA expression vectors that direct CAS9 to a specific genomic site allows identification of genes that are either enriched or depleted in response to a selection scheme, thus linking the affected gene to the chosen phenotype. The quality of the data generated by the screening is dependent on the quality of the guide RNA delivery library with regards to error rates and especially evenness of distribution of the guides. Here, we describe a method for constructing complex plasmid libraries based on pooled designed oligomers with high representation and tight distributions. The procedure allows construction of plasmid libraries of >60,000 members with a 95th/5th percentile ratio of less than 3.5.

Evaluation of “Credit Card” Libraries for Inhibition of HIV-1 gp41 Fusogenic Core Formation

PubMed Central

Xu, Yang; Lu, Hong; Kennedy, Jack P.; Yan, Xuxia; McAllister, Laura; Yamamoto, Noboru; Moss, Jason A.; Boldt, Grant E.; Jiang, Shibo; Janda, Kim D.

2008-01-01

Protein-protein interactions are of critical importance in biological systems and small molecule modulators of such protein recognition and intervention processes are of particular interests. To investigate this area of research, we have synthesized small molecule libraries that can disrupt a number of biologically relevant protein-protein interactions. These library members are designed upon planar motifs, appended with a variety of chemical functions, which we have termed as “credit-card” structures. From two of our “credit-card” libraries, a series of molecules were uncovered which act as inhibitors against the HIV-1 gp41 fusogenic 6-helix bundle core formation, viral antigen p24 formation and cell-cell fusion at low micromolar concentrations. From the high-throughput screening assays we utilized, a selective index (SI) value of 4.2 was uncovered for compound 2261, which bodes well for future structure activity investigations and the design of more potent gp41 inhibitors. PMID:16827565

A self-supporting library service in a rural region: a new look at hospital consortia.

PubMed Central

Gillikin, P; Price, L; Lee, S; Sprinkle, M D; Leist, J C

1982-01-01

To meet the informational needs of health care practitioners and trainees in a four-county rural area of northwestern North Carolina, the eleven-member UNIFOUR Consortium was founded as a two-year experimental project from 1978 to 1980. The consortium has several unique features: (1) it is an organization of institutions, not libraries; (2) it employs its own professional librarian who manages a central library, coordinates consortium programs, and makes regular circuit visits to all affiliated institutions; (3) the central library, where the circuit is based, is a developing community hospital library, not an established academic medical center library; and (4) it is ultimately tied to the Northwest Area Health Education Center and that organization's emerging learning resources network, which includes the Bowman Gray School of Medicine, Library, two other subregional libraries, and the libraries of all member institutions. At the end of the experimental period in 1980, member institutions voted unanimously to continue the program and assume their share of the costs. PMID:7039744

A self-supporting library service in a rural region: a new look at hospital consortia.

PubMed

Gillikin, P; Price, L; Lee, S; Sprinkle, M D; Leist, J C

1982-04-01

To meet the informational needs of health care practitioners and trainees in a four-county rural area of northwestern North Carolina, the eleven-member UNIFOUR Consortium was founded as a two-year experimental project from 1978 to 1980. The consortium has several unique features: (1) it is an organization of institutions, not libraries; (2) it employs its own professional librarian who manages a central library, coordinates consortium programs, and makes regular circuit visits to all affiliated institutions; (3) the central library, where the circuit is based, is a developing community hospital library, not an established academic medical center library; and (4) it is ultimately tied to the Northwest Area Health Education Center and that organization's emerging learning resources network, which includes the Bowman Gray School of Medicine, Library, two other subregional libraries, and the libraries of all member institutions. At the end of the experimental period in 1980, member institutions voted unanimously to continue the program and assume their share of the costs.

ARL Statement on Unlimited Use and Exchange of Bibliographic Records.

ERIC Educational Resources Information Center

Association of Research Libraries, Washington, DC.

The Association of Research Libraries is fully committed to the principle of unrestricted access to and dissemination of ideas, i.e., member libraries must have unlimited access to the machine-readable bibliographic records which are created by member libraries and maintained in bibliographic utilities. Coordinated collection development programs…

Rational selection of structurally diverse natural product scaffolds with favorable ADME properties for drug discovery.

PubMed

Samiulla, D S; Vaidyanathan, V V; Arun, P C; Balan, G; Blaze, M; Bondre, S; Chandrasekhar, G; Gadakh, A; Kumar, R; Kharvi, G; Kim, H O; Kumar, S; Malikayil, J A; Moger, M; Mone, M K; Nagarjuna, P; Ogbu, C; Pendhalkar, D; Rao, A V S Raja; Rao, G Venkateshwar; Sarma, V K; Shaik, S; Sharma, G V R; Singh, S; Sreedhar, C; Sonawane, R; Timmanna, U; Hardy, L W

2005-01-01

Natural product analogs are significant sources for therapeutic agents. To capitalize efficiently on the effective features of naturally occurring substances, a natural product-based library production platform has been devised at Aurigene for drug lead discovery. This approach combines the attractive biological and physicochemical properties of natural product scaffolds, provided by eons of natural selection, with the chemical diversity available from parallel synthetic methods. Virtual property analysis, using computational methods described here, guides the selection of a set of natural product scaffolds that are both structurally diverse and likely to have favorable pharmacokinetic properties. The experimental characterization of several in vitro ADME properties of twenty of these scaffolds, and of a small set of designed congeners based upon one scaffold, is also described. These data confirm that most of the scaffolds and the designed library members have properties favorable to their utilization for creating libraries of lead-like molecules.

Findings from the most recent Medical Library Association salary survey.

PubMed

Wallace, Marc; McMullen, Thomas D; Corcoran, Kate

2004-10-01

The objective is to provide information on basic issues in library management identified by the Medical Library Association's (MLA's) seventh triennial salary survey. The survey was a Web-based questionnaire. A nonrandom sample of persons was obtained by posting messages to MLA's membership and to the MEDLIB-L e-mail discussion list. Employed MLA members and nonmembers employed in medical library settings filled out a Web-based form designed using common gateway interface (CGI) programming. Six hundred forty-five usable responses were analyzed by the Hay Group and presented in the MLA publication, Hay Group/MLA 2001 Compensation and Benefits Survey. Results from the 2001 survey in this article focus on pay and job satisfaction. Salary survey results since 1983 were analyzed to review trends in seniority, diversity, and pay equity. Given the age progression of respondents from 1983 to 2001, it is clear that succession planning is a core issue for medical libraries. Although efforts to create more diversity in medical libraries in member organizations have started to yield results, pay for white respondents has increased at a higher rate than for other racial categories. The authors found that the pay-for-performance system in the organizations of approximately two-thirds of the respondents is suboptimized and that most of the reasons medical librarians cite for leaving their organization can be addressed and potentially changed by management. Results from the eighth salary survey, slated to be conducted in the fall of 2004, will further track these trends and issues.

Measuring the Performance of Document Supply Systems.

ERIC Educational Resources Information Center

Line, Maurice B.

Produced by Unesco as part of its program designed to help member states develop national information systems, including libraries, information services, and archives, this manual is a guide to document supply measurement techniques that are applicable to a wide range of countries. The first of seven chapters considers the objectives, nature, and…

Scholarly Citadel in Chicago: The Center for Research Libraries.

ERIC Educational Resources Information Center

Boylan, Ray

1979-01-01

The Center provides access to infrequently used research materials in three interrelated ways: (1) it provides a deposit library for such materials from the collections of member libraries; (2) it acquires such materials at members' shared expense and for their common use; and (3) it provides rapid access to its collection materials. (Author/JD)

Pennsylvania Library Association, Membership Survey, 1994.

ERIC Educational Resources Information Center

Obringer, Dave

This report contains the results of a survey sent to 2,883 librarians throughout Pennsylvania, both members and nonmembers of the Pennsylvania Library Association (PLA). The nonmembers of PLA were members of the American Library Association (ALA), however. The total response rate was 21% (n=620). There were recurring themes in the responses from…

Collection Development Policies. SPEC Kit 38.

ERIC Educational Resources Information Center

Association of Research Libraries, Washington, DC. Office of Management Studies.

Responses from 54 libraries to a 1977 survey of Association of Research Libraries (ARL) member institutions and interviews by Office of Management Studies staff members who visited another 15 indicated that 20 of the 69 libraries had and made use of a written collection development policy. Eight others reported that such a policy was being…

A Combinatorial H4 Tail Library to Explore the Histone Code

PubMed Central

Garske, Adam L.; Craciun, Gheorghe; Denu, John M.

2008-01-01

Histone modifications modulate chromatin structure and function. A posttranslational modification-randomized, combinatorial library based on the first twenty-one residues of histone H4 was designed for systematic examination of proteins that interpret a histone code. The 800-member library represented all permutations of most known modifications within the N-terminal tail of histone H4. To determine its utility in a protein-binding assay, the on-bead library was screened with an antibody directed against phosphoserine 1 of H4. Among the hits, 59/60 sequences were phosphorylated at S1, while 30/30 of those selected from the non-hits were unphosphorylated. A 512-member version of the library was then used to determine the binding specificity of the double tudor domain of hJMJD2A, a histone demethylase involved in transcriptional repression. Global linear least squares fitting of modifications from the identified peptides (40 hits and 34 non-hits) indicated that methylation of K20 was the primary determinant for binding, but that phosphorylation/acetylation on neighboring sites attenuated the interaction. To validate the on-bead screen, isothermal titration calorimetry was performed with thirteen H4 peptides. Dissociation constants ranged from 1 mM - 1μM and corroborated the screening results. The general approach should be useful for probing the specificity of any histone-binding protein. PMID:18616348

The professionalization of health librarianship in the UK between 1909 and 1978.

PubMed

Ferguson, Valerie

2005-09-01

Many strands exist within health information work and during the last century librarians in this field identified themselves through special groups or associations. This paper focuses on the key role of the Library Association Medical Section in the professional development of medical librarians in the United Kingdom up to 1978 when it merged with the Library Association Hospital Libraries and Handicapped Readers Group to create the Medical, Health and Welfare Group. Uniting to form a stronger organization, under the ultimate designation of the Health Libraries Group, was part of an evolutionary process. The invention and promotion of co-operative schemes, networking and educational opportunities for members, the publication of specialized material and the fostering of international relationships during the first three-quarters of the century are illuminated by personal reminiscences from some of the major participants in the field.

The Oral History Program: II. Personal views of health sciences librarianship and the Medical Library Association.

PubMed

McKenzie, D; Pifalo, V

1998-07-01

The Medical Library Association Oral History Program uses accepted oral history techniques to collect and preserve interviews with members. The original taped interviews and transcripts are kept in the Medical Library Association archives and made available for research purposes; edited copies of the interviews are distributed through the National Network of Libraries of Medicine, and members are encouraged to borrow and read the histories. Summaries of forty-three interviews provide personal views on health sciences librarianship and the Medical Library Association.

The Oral History Program: II. Personal views of health sciences librarianship and the Medical Library Association.

PubMed Central

McKenzie, D; Pifalo, V

1998-01-01

The Medical Library Association Oral History Program uses accepted oral history techniques to collect and preserve interviews with members. The original taped interviews and transcripts are kept in the Medical Library Association archives and made available for research purposes; edited copies of the interviews are distributed through the National Network of Libraries of Medicine, and members are encouraged to borrow and read the histories. Summaries of forty-three interviews provide personal views on health sciences librarianship and the Medical Library Association. PMID:9681172

The Oral History Program: III. Personal views of health sciences librarianship and the Medical Library Association.

PubMed Central

McKenzie, D; Pifalo, V

1998-01-01

The Medical Library Association Oral History Program uses accepted oral history techniques to collect and preserve interviews with members. The original taped interviews and transcripts are kept in the Medical Library Association archives and made available for research purposes; edited copies of the interviews are distributed through the National Network of Libraries of Medicine, and members are encouraged to borrow and read the histories. Summaries of forty-three interviews provide personal views on health sciences librarianship and the Medical Library Association. PMID:9803287

Benefits for Professional Staff in ARL Libraries. SPEC Kit 197.

ERIC Educational Resources Information Center

Switzer, Teri R., Comp.

The kit and flyer explore employee benefits offered to professional staff by member institutions of the Association of Research Libraries (ARL). To find out about these benefits, ARL surveyed its 119 members in 1993, and received 71 replies. Of responding libraries, 100% provide health care insurance, 69% have a major medical plan, while 86.4%…

Library services for people with disabilities: results of a survey.

PubMed Central

Nelson, P P

1996-01-01

The Americans with Disabilities Act (ADA), enacted in 1990, has had a significant impact on the way many institutions, including libraries, do business. The Association of Research Libraries surveyed its members in 1991 to determine the effect of this legislation, and the author conducted a similar survey in 1995 to learn what progress academic health sciences libraries have made in serving the needs of people with disablities. A questionnaire was mailed to 131 members of the Association of Academic Health Sciences Library Directors. Nearly three-quarters of respondents reported elimination of physical barriers. The most common services provided are retrieval of materials from the stacks and photocopy assistance. Much less attention has been paid to the use of adaptive technology that allows disabled users to search a library's online catalog and databases; special technology is often provided by another unit on campus but there seems to be little coordination with library services Few libraries have assigned responsibility for disability services to a specific staff member and even fewer have done a formal assessment of the need for special services. The issues identified by the survey should challenge academic health sciences libraries to examine their status regarding compliance with ADA legislation. PMID:8883988

Parallel and automated library synthesis of 2-long alkyl chain benzoazoles and azole[4,5-b]pyridines under microwave irradiation.

PubMed

Martínez-Palou, Rafael; Zepeda, L Gerardo; Höpfl, Herbert; Montoya, Ascensión; Guzmán-Lucero, Diego J; Guzmán, Javier

2005-01-01

A versatile route to 40-membered library of 2-long alkyl chain substituted benzoazoles (1 and 2) and azole[4,5-b]pyridines (3 and 4) via microwave-assisted combinatorial synthesis was developed. The reactions were carried out in both monomode and multimode microwave oven. With the latter, all reactions were performed in high-throughput experimental settings consisting of an 8 x 5 combinatorial library designed to synthesize 40 compounds. Each step, from the addition of reagents to the recovery of final products, was automated. The microwave-assisted N-long chain alkylation reactions of 2-alkyl-1H-benzimidazole (1) and 2-alkyl-1H-benzimidazole[4,5-b] pyridines (3) were also studied.

Digitally encoded DNA nanostructures for multiplexed, single-molecule protein sensing with nanopores

NASA Astrophysics Data System (ADS)

Bell, Nicholas A. W.; Keyser, Ulrich F.

2016-07-01

The simultaneous detection of a large number of different analytes is important in bionanotechnology research and in diagnostic applications. Nanopore sensing is an attractive method in this regard as the approach can be integrated into small, portable device architectures, and there is significant potential for detecting multiple sub-populations in a sample. Here, we show that highly multiplexed sensing of single molecules can be achieved with solid-state nanopores by using digitally encoded DNA nanostructures. Based on the principles of DNA origami, we designed a library of DNA nanostructures in which each member contains a unique barcode; each bit in the barcode is signalled by the presence or absence of multiple DNA dumbbell hairpins. We show that a 3-bit barcode can be assigned with 94% accuracy by electrophoretically driving the DNA structures through a solid-state nanopore. Select members of the library were then functionalized to detect a single, specific antibody through antigen presentation at designed positions on the DNA. This allows us to simultaneously detect four different antibodies of the same isotype at nanomolar concentration levels.

Digitally encoded DNA nanostructures for multiplexed, single-molecule protein sensing with nanopores.

PubMed

Bell, Nicholas A W; Keyser, Ulrich F

2016-07-01

The simultaneous detection of a large number of different analytes is important in bionanotechnology research and in diagnostic applications. Nanopore sensing is an attractive method in this regard as the approach can be integrated into small, portable device architectures, and there is significant potential for detecting multiple sub-populations in a sample. Here, we show that highly multiplexed sensing of single molecules can be achieved with solid-state nanopores by using digitally encoded DNA nanostructures. Based on the principles of DNA origami, we designed a library of DNA nanostructures in which each member contains a unique barcode; each bit in the barcode is signalled by the presence or absence of multiple DNA dumbbell hairpins. We show that a 3-bit barcode can be assigned with 94% accuracy by electrophoretically driving the DNA structures through a solid-state nanopore. Select members of the library were then functionalized to detect a single, specific antibody through antigen presentation at designed positions on the DNA. This allows us to simultaneously detect four different antibodies of the same isotype at nanomolar concentration levels.

Trailblazing in East Texas: A Progress Report on the Forest Trail Library Consortium's Networking Project.

ERIC Educational Resources Information Center

Claer, Joycelyn H.

This report describes the development of the Forest Trail Library Consortium (FTLC), a network of academic, public, and school libraries in Texas. The growth of FTLC from 4 charter members to its current 16 members is traced, including details about goals and funding. The role of special interest groups (SIGs) is examined, and the goals and…

Findings from the most recent Medical Library Association salary survey

PubMed Central

Wallace, Marc; McMullen, Thomas D.; Corcoran, Kate

2004-01-01

Objective: The objective is to provide information on basic issues in library management identified by the Medical Library Association's (MLA's) seventh triennial salary survey. Methods: The survey was a Web-based questionnaire. A nonrandom sample of persons was obtained by posting messages to MLA's membership and to the MEDLIB-L email discussion list. Employed MLA members and nonmembers employed in medical library settings filled out a Web-based form designed using common gateway interface (CGI) programming. Results: Six hundred forty-five usable responses were analyzed by the Hay Group and presented in the MLA publication, Hay Group/MLA 2001 Compensation and Benefits Survey. Results from the 2001 survey in this article focus on pay and job satisfaction. Salary survey results since 1983 were analyzed to review trends in seniority, diversity, and pay equity. Conclusions: Given the age progression of respondents from 1983 to 2001, it is clear that succession planning is a core issue for medical libraries. Although efforts to create more diversity in medical libraries in member organizations have started to yield results, pay for white respondents has increased at a higher rate than for other racial categories. The authors found that the pay-for-performance system in the organizations of approximately two-thirds of the respondents is suboptimized and that most of the reasons medical librarians cite for leaving their organization can be addressed and potentially changed by management. Results from the eighth salary survey, slated to be conducted in the fall of 2004, will further track these trends and issues. PMID:15494762

Bacterial Artificial Chromosome Libraries for Mouse Sequencing and Functional Analysis

PubMed Central

Osoegawa, Kazutoyo; Tateno, Minako; Woon, Peng Yeong; Frengen, Eirik; Mammoser, Aaron G.; Catanese, Joseph J.; Hayashizaki, Yoshihide; de Jong, Pieter J.

2000-01-01

Bacterial artificial chromosome (BAC) and P1-derived artificial chromosome (PAC) libraries providing a combined 33-fold representation of the murine genome have been constructed using two different restriction enzymes for genomic digestion. A large-insert PAC library was prepared from the 129S6/SvEvTac strain in a bacterial/mammalian shuttle vector to facilitate functional gene studies. For genome mapping and sequencing, we prepared BAC libraries from the 129S6/SvEvTac and the C57BL/6J strains. The average insert sizes for the three libraries range between 130 kb and 200 kb. Based on the numbers of clones and the observed average insert sizes, we estimate each library to have slightly in excess of 10-fold genome representation. The average number of clones found after hybridization screening with 28 probes was in the range of 9–14 clones per marker. To explore the fidelity of the genomic representation in the three libraries, we analyzed three contigs, each established after screening with a single unique marker. New markers were established from the end sequences and screened against all the contig members to determine if any of the BACs and PACs are chimeric or rearranged. Only one chimeric clone and six potential deletions have been observed after extensive analysis of 113 PAC and BAC clones. Seventy-one of the 113 clones were conclusively nonchimeric because both end markers or sequences were mapped to the other confirmed contig members. We could not exclude chimerism for the remaining 41 clones because one or both of the insert termini did not contain unique sequence to design markers. The low rate of chimerism, ∼1%, and the low level of detected rearrangements support the anticipated usefulness of the BAC libraries for genome research. [The sequence data described in this paper have been submitted to the GenBank data library under accession numbers AQ797173–AQ797398.] PMID:10645956

Community-led cancer action councils in Queens, New York: process evaluation of an innovative partnership with the Queens library system.

PubMed

Basu Roy, Upal; Michel, Tamara; Carpenter, Alison; Lounsbury, David W; Sabino, Eilleen; Stevenson, Alexis Jurow; Combs, Sarah; Jacobs, Jasmine; Padgett, Deborah; Rapkin, Bruce D

2014-02-06

Community-based participatory research (CBPR) has great potential to address cancer disparities, particularly in racially and ethnically diverse and underserved neighborhoods. The objective of this study was to conduct a process evaluation of an innovative academic-community partnership, Queens Library HealthLink, which aimed to reduce cancer disparities through neighborhood groups (Cancer Action Councils) that convened in public libraries in Queens, New York. We used a mixed-methods approach to conduct 69 telephone survey interviews and 4 focus groups (15 participants) with Cancer Action Council members. We used 4 performance criteria to inform data collection: action or attention to sustainability, library support for the council, social cohesion and group leadership, and activity level. Focus group transcripts were independently coded and cross-checked for consensus until saturation was achieved. Members reported benefits and barriers to participation. Thirty-three original focus group transcript codes were organized into 8 main themes related to member experiences: 1) library as a needed resource, 2) library as a reputable and nondenominational institution, 3) value of library staff, 4) need for a HealthLink specialist, 5) generation of ideas and coordination of tasks, 6) participation challenges, 7) use of community connections, and 8) collaboration for sustainability. In response to the process evaluation, Cancer Action Council members and HealthLink staff incorporated member suggestions to improve council sustainability. The councils merged to increase intercouncil collaboration, and institutional changes were made in funding to sustain a HealthLink specialist beyond the grant period.

Public Libraries As Partners for Health

PubMed Central

Dupuis, Roxanne; Morgan, Anna U.; D’Alonzo, Bernadette; Epstein, Caleb; Klusaritz, Heather; Cannuscio, Carolyn C.

2018-01-01

Introduction Public libraries are free and accessible to all and are centers of community engagement and education, making them logical choices as partners for improving population health. Library staff members routinely assist patrons with unmet health and social needs. Methods We used a 100-question, self-administered web survey sent to all library directors listed in the Pennsylvania Library Association database (N = 621), to investigate staff interactions with library patrons to address social determinants of health. We conducted statistical comparisons of quantitative responses and a content analysis of open-ended responses. Results Respondents (N = 262) reported frequently interacting with patrons around health and social concerns — well beyond those related to literacy and education — including help with employment (94%), nutrition (70%), exercise (66%), and social welfare benefits (51%). Acute emergencies were not uncommon in Pennsylvania’s public libraries, with nearly 12% of respondents having witnessed a drug overdose at the library in the past year. Most respondents felt that their professional training left them inadequately prepared to assist patrons with health and social issues. Although at least 40% of respondents offered some health programming at their library branch, their offerings did not meet the high level of need reflected in common patron inquiries. Conclusion The challenges library staff members experience in meeting their patrons’ information needs suggest opportunities for public libraries to advance population health. Library staff members need additional training and resources and collaboration with public health and health care institutions to respond to community needs through effective, evidence-based public health programming. PMID:29806580

Public Libraries As Partners for Health.

PubMed

Whiteman, Eliza D; Dupuis, Roxanne; Morgan, Anna U; D'Alonzo, Bernadette; Epstein, Caleb; Klusaritz, Heather; Cannuscio, Carolyn C

2018-05-24

Public libraries are free and accessible to all and are centers of community engagement and education, making them logical choices as partners for improving population health. Library staff members routinely assist patrons with unmet health and social needs. We used a 100-question, self-administered web survey sent to all library directors listed in the Pennsylvania Library Association database (N = 621), to investigate staff interactions with library patrons to address social determinants of health. We conducted statistical comparisons of quantitative responses and a content analysis of open-ended responses. Respondents (N = 262) reported frequently interacting with patrons around health and social concerns - well beyond those related to literacy and education - including help with employment (94%), nutrition (70%), exercise (66%), and social welfare benefits (51%). Acute emergencies were not uncommon in Pennsylvania's public libraries, with nearly 12% of respondents having witnessed a drug overdose at the library in the past year. Most respondents felt that their professional training left them inadequately prepared to assist patrons with health and social issues. Although at least 40% of respondents offered some health programming at their library branch, their offerings did not meet the high level of need reflected in common patron inquiries. The challenges library staff members experience in meeting their patrons' information needs suggest opportunities for public libraries to advance population health. Library staff members need additional training and resources and collaboration with public health and health care institutions to respond to community needs through effective, evidence-based public health programming.

Library Service in Delaware.

ERIC Educational Resources Information Center

Humphry, John A.; Humphry, James, III

This study which gives detailed recommendations for the implementation of a state-wide library improvement program for Delaware is based on visits to all types of libraries and library agencies in the state and conference with members of the State Library Commission, library trustees, state and local officials, librarians and interested laymen.…

New Mexico Library Directory and Statistics. 1995.

ERIC Educational Resources Information Center

Baca, Chris L., Ed.

This directory identifies members of the New Mexico State Library Commission, the New Mexico Advisory Council on Libraries, and staff at the New Mexico State Library. It goes on to list New Mexico libraries alphabetically by city. Within each city libraries are subdivided into public, academic, special, and school categories. Electronic mail…

The Multitype Library Network.

ERIC Educational Resources Information Center

Dejohn, William, Ed.; Lamont, Bridget L., Ed.

1975-01-01

"Illinois Libraries" for June, 1975, is devoted to interlibrary cooperation and the multitype library network as exemplified by the Illinois Library and Information Network (ILLINET). The history, geographical coverage, member and affiliate libraries, and the workings of the network at various levels are described. A second section…

Understanding the Concept of Information Literacy Students--For Example, the City Library "Don Mihovil Pavlinovic" Imotski

ERIC Educational Resources Information Center

Jovic, Marija

2016-01-01

This paper presents the results of a study on the understanding of the term information literacy of primary and secondary school students, from the fifth grade of elementary school to the fourth year of high school at the local level, and who are members of the City Library in Imotski. The study examined 98 members of the City Library, through a…

The Library's Public Revisited, By Members of the Class in The Public Library in the Political Process.

ERIC Educational Resources Information Center

Bundy, Mary Lee, Ed.; Goodstein, Sylvia, Ed.

A group of students in the course dealt with the fundamental question of the public library's role in satisfying societal needs. Each of the students set out to explore the family, social, occupational and political world of an important social group. Members of two of the groups - the urban Negro and the blue collar worker - appeared to be either…

Texas Library Systems Act and Rules for Administering the Library Systems Act.

ERIC Educational Resources Information Center

Texas State Library, Austin. Dept. of Library Development.

This booklet presents the Texas State Library Systems Act and some supporting documents to help in the operation of a library under the Texas system. The State Library Systems Act establishes and defines the state library system, allowing for its operation and management and defining the member libraries. Information on state grants is provided,…

Helix-packing motifs in membrane proteins.

PubMed

Walters, R F S; DeGrado, W F

2006-09-12

The fold of a helical membrane protein is largely determined by interactions between membrane-imbedded helices. To elucidate recurring helix-helix interaction motifs, we dissected the crystallographic structures of membrane proteins into a library of interacting helical pairs. The pairs were clustered according to their three-dimensional similarity (rmsd

High-throughput resistivity apparatus for thin-film combinatorial libraries

NASA Astrophysics Data System (ADS)

Hewitt, K. C.; Casey, P. A.; Sanderson, R. J.; White, M. A.; Sun, R.

2005-09-01

An apparatus, capable of measuring the dc resistance versus temperature of a 49-member library prepared by thin-film deposition techniques was designed and tested. The library is deposited by dc magnetron sputtering onto 10.16cm×10.16cm alumina substrates on which are placed aluminum masks consisting of 8mm diam holes cut on a 7×7 grid, the center-to-center spacing being 10.15mm. Electrical contact to the library is made in a standard van der Pauw geometry using 196 spring-loaded, gold-coated pins, four pins for each member of the library. The temperature is controlled using a helium refrigerator in combination with a liquid-nitrogen radiation shield that greatly reduces radiative heating of the sample stage. With the radiation shield, the cold finger is able to sustain a minimum temperature of 7K and the sample stage a minimum temperature of 27K. The temperature (27-291K) dependent dc resistivity of a thin-film silver library of varying thickness (48-639nm) is presented to highlight the capabilities of the apparatus. The thickness dependence of both the resistivity and the temperature coefficient of resistivity are quantitatively consistent with the literature. For thicknesses greater than about 100nm, the room-temperature resistivity (3.4μΩcm) are consistent with Matthiessen's rule for 1%-2% impurity content, and the temperature coefficient of resistivity is consistent with the bulk value. For thicknesses less than 100nm, an increase in resistivity by a factor of 8 is found, which may be due to surface and boundary scattering effects; a corresponding increase in the temperature coefficient of resistivity is consistent with a concomitant decrease in the magnitude of the elastic constants and surface scattering effects.

Oklahoma Library Trustee Handbook, 1996.

ERIC Educational Resources Information Center

Oklahoma State Dept. of Libraries, Oklahoma City. Office of Library Development.

Library board members are an integral part of public libraries. Because of the importance of their role, this handbook gives library trustees in Oklahoma a basic understanding of their responsibilities and power. It contains useful information about developing policy, the board/director relationship, funding, intellectual freedom, library laws,…

Efficient engineering of chromosomal ribosome binding site libraries in mismatch repair proficient Escherichia coli.

PubMed

Oesterle, Sabine; Gerngross, Daniel; Schmitt, Steven; Roberts, Tania Michelle; Panke, Sven

2017-09-26

Multiplexed gene expression optimization via modulation of gene translation efficiency through ribosome binding site (RBS) engineering is a valuable approach for optimizing artificial properties in bacteria, ranging from genetic circuits to production pathways. Established algorithms design smart RBS-libraries based on a single partially-degenerate sequence that efficiently samples the entire space of translation initiation rates. However, the sequence space that is accessible when integrating the library by CRISPR/Cas9-based genome editing is severely restricted by DNA mismatch repair (MMR) systems. MMR efficiency depends on the type and length of the mismatch and thus effectively removes potential library members from the pool. Rather than working in MMR-deficient strains, which accumulate off-target mutations, or depending on temporary MMR inactivation, which requires additional steps, we eliminate this limitation by developing a pre-selection rule of genome-library-optimized-sequences (GLOS) that enables introducing large functional diversity into MMR-proficient strains with sequences that are no longer subject to MMR-processing. We implement several GLOS-libraries in Escherichia coli and show that GLOS-libraries indeed retain diversity during genome editing and that such libraries can be used in complex genome editing operations such as concomitant deletions. We argue that this approach allows for stable and efficient fine tuning of chromosomal functions with minimal effort.

Library Research Support in Queensland: A Survey

ERIC Educational Resources Information Center

Richardson, Joanna; Nolan-Brown, Therese; Loria, Pat; Bradbury, Stephanie

2012-01-01

University libraries worldwide are reconceptualising the ways in which they support the research agenda in their respective institutions. This paper is based on a survey completed by member libraries of the Queensland University Libraries Office of Cooperation (QULOC), the findings of which may be informative for other university libraries. After…

Management Preparation and Training of Department Heads in ARL Libraries.

ERIC Educational Resources Information Center

Wittenbach, Stefanie A.; And Others

1992-01-01

A survey of cataloging and reference department heads in ARL (Association for Research Libraries) member libraries showed that both professional experience and management coursework play a part in a librarian's promotion to department head. It is suggested that library management will improve if libraries require formal management preparation and…

Academic Library Development Program: A Self Study.

ERIC Educational Resources Information Center

Carnegie-Mellon Univ., Pittsburgh, PA. University Libraries.

Results of a 4-month library self-evaluation program conducted by staff members at Carnegie-Mellon University Libraries are reported in this document. The study was conducted using the Academic Library Development Program (ALDP), a self-improvement strategy for libraries to evaluate and develop their performance. The study team consisting of four…

Fostering Research and Publication in Academic Libraries

ERIC Educational Resources Information Center

Sassen, Catherine; Wahl, Diane

2014-01-01

This study concerns administrative support provided to encourage the research and publishing activities of academic librarians working in Association of Research Libraries member libraries. Deans and directors of these libraries were asked to respond to an online survey concerning the support measures that their libraries provide, as well as their…

Special Libraries.

ERIC Educational Resources Information Center

Foskett, D. J.

The Special Library is distinguished from other libraries as being a library serving a particular group of readers, who have an existence as a group outside of their readership of the library, and whose members direct at least some of their activities towards a common purpose. Thus, the special librarian's first and major responsibility is to know…

Accessing Digital Libraries: A Study of ARL Members' Digital Projects

ERIC Educational Resources Information Center

Kahl, Chad M.; Williams, Sarah C.

2006-01-01

To ensure efficient access to and integrated searching capabilities for their institution's new digital library projects, the authors studied Web sites of the Association of Research Libraries' (ARL) 111 academic, English-language libraries. Data were gathered on 1117 digital projects, noting library Web site and project access, metadata, and…

The Academic Library Impact on Student Persistence

ERIC Educational Resources Information Center

Emmons, Mark; Wilkinson, Frances C.

2011-01-01

What impact does the academic library have on student persistence? This study explores the relationship between traditional library input and output measures of staff, collections, use, and services with fall-to-fall retention and six-year graduation rates at Association of Research Libraries member libraries. When controlling for race/ethnicity…

NOAA Photo Library - Meet the Photographers/Rear Admiral Harley D. Nygren,

Science.gov Websites

a past member of The Board of Directors of the Retired Officers Association, an active member of the Board of the National Association for Uniformed Services, and a member of the Board of Directors of NOAA Corps (Retired)A> NOAA Photo Library Banner Takes you to the Top Page Takes you to the

Breaking New Ground: The Case for Seed Libraries in the Academic Library

ERIC Educational Resources Information Center

Ingalls, Dana

2017-01-01

Seed libraries are a relatively new innovation in the library field, offering seeds, gardening information, and the opportunity for community and ecological engagement to members. While they are increasingly popular in public libraries, they have not yet established a foothold in academic libraries. This paper defines the nature and role of seed…

A Bibliographic Bank for Resource Sharing in Library Systems: A Feasibility Study. Final Report.

ERIC Educational Resources Information Center

Schwartz, Eugene S.; Saxe, Henry I.

This study of resource sharing among public libraries was made possible by six library systems in northern Illinois. With the organization of the library systems and development of interlibrary loan services and other cooperative activities, the problem of extending resource sharing among member libraries and between library systems arose. Several…

Investigating the need for scholarly communications positions in Association of Academic Health Sciences Libraries member institutions.

PubMed

Mears, Kim; Bandy, Sandra L

2017-04-01

The role of health sciences librarians has expanded in the scholarly communications landscape as a result of the increase in federal public access mandates and the continued expansion of publishing avenues. This has created the need to investigate whether academic health sciences libraries should have scholarly communications positions to provide education and services exclusively related to scholarly communication topics. A nine-question online survey was distributed through the Association of Academic Health Sciences Libraries (AAHSL) email discussion list to gather preliminary findings from and opinions of directors of health sciences libraries on the need for scholarly communications positions. The survey received a 38% response rate. The authors found that AAHSL members are currently providing scholarly communications services, and 46% of respondents expressed the need to devote a full-time position to this role. Our survey reveals a juxtaposition occurring in AAHSL member libraries. While administrators acknowledge the need to provide scholarly communications services, they often experience budget challenges in providing a full-time position for these services.

The Gap in Standards for Special Libraries.

ERIC Educational Resources Information Center

Dodd, James Beaupre

1982-01-01

The issue of standards for special libraries is discussed, highlighting surveys conducted concerning the diversity of special libraries and salaries of members of the Special Libraries Association (SLA). Efforts of SLA's Standards and Statistics Committee are noted. Twenty references are listed. (EJS)

Strengthening professionals: a chapter-level formative evaluation of the Medical Library Association mentoring initiative.

PubMed

Kwasik, Hanna; Fulda, Pauline O

2006-01-01

The main objective was to determine to what extent the Medical Library Association (MLA) mentoring initiative was implemented in the South Central Chapter of the Medical Library Association (SCC/ MLA) and to identify the needs, improvements, and adjustments in mentoring services for the future to improve the practice of librarianship. The data were collected by administering an anonymous structured survey designed by the authors. The survey was mailed to all 335 chapter members. The authors elicited responses to determine the chapter members' mentoring needs, awareness of available resources, satisfaction with existing services and resources, needs for the future, and suggestions to meet those needs. Of the 335 delivered surveys, 184 were returned, yielding a return rate of 55%. Eighty percent had a mentor or mentors in their careers, and 74% were either very satisfied or satisfied with the relationship. The majority considered having a mentor a critical part of the professional experience. The mentoring activity chosen by respondents as the most important was improvement of job performance through skills development. Over 50% were aware of SCC/MLA's mentoring activities, and less than 50% were aware of MLA's mentoring Website. The rate of response and the wealth of comments provided by respondents document the high level of interest in mentoring by medical librarians in the region. The following mentoring services were equally important to SCC/MLA members and were recommended for improvement or development at the regional level: a formalized mentoring program in the region, Web-based mentoring resources on the SCC/MLA Website, and a continuing education course for mentors. Members are aware of mentoring activities in the region; however, participation levels need to be increased in activities that SCC/MLA and MLA provide. Mentoring continues to evolve as a service in the profession.

Leadership Diversity: A Study of Urban Public Libraries

ERIC Educational Resources Information Center

Winston, Mark; Li, Haipeng

2007-01-01

Diversity has been identified as a priority in library and information services for some time. The limited published research on diversity programs in libraries, though, has focused on academic libraries. This article represents the results of a study of leadership diversity in large, urban public libraries. In the study of members of the Urban…

Making Wise Buys: Five Values to Consider when Evaluating a Library Purchase

ERIC Educational Resources Information Center

Durr, Chris

2011-01-01

Library staff members should ultimately base their purchasing choices on the mission statements of their employing institutions. Fortunately, library mission statements have much in common. Undoubtedly, for example, all libraries have a goal that includes "serve the information needs of the community," because on some level, all libraries are…

28 CFR 544.101 - Procedures.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Library Services § 544.101 Procedures. (a) The Warden shall assign a staff member (ordinarily the Supervisor of Education) responsibility for the inmate library. (b) The inmate library shall offer an inmate... origin, staff shall attempt to provide reading materials in the inmates' language. (d) Inmate library...

28 CFR 544.101 - Procedures.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Library Services § 544.101 Procedures. (a) The Warden shall assign a staff member (ordinarily the Supervisor of Education) responsibility for the inmate library. (b) The inmate library shall offer an inmate... origin, staff shall attempt to provide reading materials in the inmates' language. (d) Inmate library...

28 CFR 544.101 - Procedures.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Library Services § 544.101 Procedures. (a) The Warden shall assign a staff member (ordinarily the Supervisor of Education) responsibility for the inmate library. (b) The inmate library shall offer an inmate... origin, staff shall attempt to provide reading materials in the inmates' language. (d) Inmate library...

28 CFR 544.101 - Procedures.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Library Services § 544.101 Procedures. (a) The Warden shall assign a staff member (ordinarily the Supervisor of Education) responsibility for the inmate library. (b) The inmate library shall offer an inmate... origin, staff shall attempt to provide reading materials in the inmates' language. (d) Inmate library...

28 CFR 544.101 - Procedures.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Library Services § 544.101 Procedures. (a) The Warden shall assign a staff member (ordinarily the Supervisor of Education) responsibility for the inmate library. (b) The inmate library shall offer an inmate... origin, staff shall attempt to provide reading materials in the inmates' language. (d) Inmate library...

El Instituto de Nutrición de Centro América y Panamá: Servicios de Información Científica en Una Región en Vía de Desarrollo *

PubMed Central

Flores, Raquel; Corado, Adelina; Girón, Arturo

1964-01-01

Pioneering scientific information in underdeveloped areas poses several problems, such as (1) lack of understanding on the part of key functionaries as to the why, what, and when of information services; (2) lack of trained personnel to assume the responsibility for such services; (3) lack of economic resources; and (4) lack of information pertaining to available bibliographical sources in the particular area or region. The Bibliographic and Documentation Service of the Institute of Nutrition of Central America and Panama (INCAP) provides, in addition to the customary services, technical assistance for the organization or reorganization of biomedical libraries and makes INCAP library materials available to member countries, either by loan or photocopy. Although the program was designed for the member countries, INCAP tries to make its services available to other Latin American nations, Africa, and Asia, where similar nutritional problems are being studied. PMID:14119292

Data Sharing Interviews with Crop Sciences Faculty: Why They Share Data and How the Library Can Help

ERIC Educational Resources Information Center

Williams, Sarah C.

2013-01-01

This study was designed to generate a deeper understanding of data sharing by targeting faculty members who had already made data publicly available. During interviews, crop scientists at the University of Illinois at Urbana-Champaign were asked why they decided to share data, why they chose a data sharing method (e. g., supplementary file,…

Goals & Objectives Statements. SPEC Kit 15.

ERIC Educational Resources Information Center

Association of Research Libraries, Washington, DC. Office of Management Studies.

This collection of statements of goals and objectives from member libraries of the Association of Research Libraries (ARL) contains: (1) sections from management review and analysis program reports from the University of Washington Libraries and the University of Rochester Library; (2) a detailed organization description from the Columbia…

The Digital Library for Earth System Education: A Progress Report from the DLESE Program Center

NASA Astrophysics Data System (ADS)

Marlino, M. R.; Sumner, T. R.; Kelly, K. K.; Wright, M.

2002-12-01

DLESE is a community-owned and governed digital library offering easy access to high quality electronic resources about the Earth system at all educational levels. Currently in its third year of development and operation, DLESE resources are designed to support systemic educational reform, and include web-based teaching resources, tools, and services for the inclusion of data in classroom activities, as well as a "virtual community center" that supports community goals and growth. "Community-owned" and "community-governed" embody the singularity of DLESE through its unique participatory approach to both library building and governance. DLESE is guided by policy development vested in the DLESE Steering Committee, and informed by Standing Committees centered on Collections, Services, Technology, and Users, and community working groups covering a wide variety of interest areas. This presentation highlights both current and projected status of the library and opportunities for community engagement. It is specifically structured to engage community members in the design of the next version of the library release. The current Version 1.0 of the library consists of a web-accessible graphical user interface connected to a database of catalogued educational resources (approximately 3000); a metadata framework enabling resource characterization; a cataloging tool allowing community cataloging and indexing of materials; a search and discovery system allowing browsing based on topic, grade level, and resource type, and permitting keyword and controlled vocabulary-based searches; and a portal website supporting library use, community action, and DLESE partnerships. Future stages of library development will focus on enhanced community collaborative support; development of controlled vocabularies; collections building and community review systems; resource discovery integrating the National Science Education Standards and geography standards; Earth system science vocabulary; georeferenced discovery; and ultimately, AAAS Benchmarks. DLESE is being designed from the outset to support resource discovery across a diverse, federated network of holdings and collections, including the Alexandria Digital Library Earth Prototype (ADL/ADEPT), NASA education collections, the DLESE reviewed collection, and other community-held resources that have been cataloged and indexed as part of the overall DLESE collections.

North Dakota Public Library Trustee Manual.

ERIC Educational Resources Information Center

North Dakota Library Association, Bismarck.

Intended as a guide for public library board members of the state of North Dakota, this manual provides basic information that all trustees should have and suggestions that will help them become more active and useful not only to their library and community but also to libraries and library services in the state. Subjects covered include goals,…

Merchants of Light: The Paris Library School, Internationalism, and the Globalization of a Profession

ERIC Educational Resources Information Center

Witt, Steven

2013-01-01

Amid growing isolationism after World War I, the American Library Association transferred its wartime programs to train librarians in Europe and promote the American model of public libraries. Working in collaboration with American philanthropists and members of the French library community, ALA established a permanent library school in Paris that…

Organization Charts in ARL Libraries. SPEC Kit #170.

ERIC Educational Resources Information Center

Association of Research Libraries, Washington, DC. Office of Management Studies.

This kit is based on a review of the organization charts of 71 member libraries of the Association of Research Libraries (ARL) gathered in January 1991, compared with an earlier SPEC Kit published in 1986, and contains charts of 29 of the libraries. A summary of the chart analyses presents information about the titles of library directors,…

Friends of the National Library of Medicine

MedlinePlus

... Current Issue Past Issues Friends of the National Library of Medicine Past Issues / Summer 2006 Table of ... Paul G. Rogers Chairman, Friends of the National Library of Medicine and former member of the U.S. ...

Federated Search and the Library Web Site: A Study of Association of Research Libraries Member Web Sites

ERIC Educational Resources Information Center

Williams, Sarah C.

2010-01-01

The purpose of this study was to investigate how federated search engines are incorporated into the Web sites of libraries in the Association of Research Libraries. In 2009, information was gathered for each library in the Association of Research Libraries with a federated search engine. This included the name of the federated search service and…

Attitudes about OCLC in Small and Medium-Sized Libraries. Illinois Valley Library System OCLC Experimental Project. Report No. 4.

ERIC Educational Resources Information Center

Bills, Linda G.; Wilford, Valerie

A project was conducted from 1980 to 1982 to determine the costs and benefits of OCLC use in 29 small and medium-sized member libraries of the Illinois Valley Library System (IVLS). Academic, school, public, and special libraries participated in the project. Based on written attitude surveys of and interviews with library directors, staff,…

A Study of Four Library Programs for Disadvantaged Persons. Part II, Appendices B: Brooklyn Public Library Community Coordinator Project, the New York Public Library North Manhattan Project.

ERIC Educational Resources Information Center

Winsor, Charlotte B.; Burrows, Lodema

This document contains observations of library staff and interviews with community members about the Brooklyn Public Library Community Coordinator Project and the New York Public Library North Manhattan Project. The Community Coordinator Project employs four professional librarians to take an active part in community institutions and organizations…

System Migration in ARL Libraries. SPEC Kit 185.

ERIC Educational Resources Information Center

Pattie, Ling-yuh W.; Lach, Michael

This publication reports results of a survey of 83 ARL (Association of Research Libraries) member libraries that examined the decision making process in migration from one automated library system to another. Data are reported on planning; implementation; workflow redesign; and training, publicity, and evaluation. Supplemental materials include:…

Information Policy -- Distance Education: Provider and Victim Libraries.

ERIC Educational Resources Information Center

Heron, Peter; Dugan, Robert E.

1997-01-01

This discussion of information policy focuses on library services for distance education. Topics include the logistics and management of providing library services off-site and/or responding to student requests; and meeting the needs of distance education students for information and library instruction, both students from the member institution…

Patterns in the Use of OCLC by Academic Library Cataloging Departments.

ERIC Educational Resources Information Center

Moore, Barbara

1981-01-01

A survey of the cataloging departments of 166 OCLC-member academic libraries showed that these libraries do not rely exclusively on OCLC for card production and that a large majority do not accept non-Library of Congress OCLC records without substantial checking. Three references are noted. (Author/FM)

The Systems Function. SPEC Kit 29.

ERIC Educational Resources Information Center

Association of Research Libraries, Washington, DC. Office of Management Studies.

This kit on the systems functions in Association of Research Libraries (ARL) member institutions contains 10 source documents from ARL libraries and a summary of data from a 1976 survey on the organization, staffing, and operation of library systems functions. Source documents include: (1) "Library Systems Office Annual Report, 1974-75"…

Building Renovation in ARL Libraries. SPEC Kit 97.

ERIC Educational Resources Information Center

Hersberger, Rodney M.

This collection of library documents related to building renovation, by members of the Association of Research Libraries (ARL), contains excerpts from: (1) a plan for upgrading and expanding library facilities at the University of Kansas; (2) a report on storage facilities at Rutgers University; (3) documents presenting the essential remodeling…

Floating and Idea: Peer Observations across the Mississippi

ERIC Educational Resources Information Center

Heinzman, Mary; Weaver, David

2006-01-01

During the 2001-2002 academic year, Augustana College Library (Rock Island, IL) and St. Ambrose University Library (Davenport, IA) began a unique joint venture of peer observation between the reference staff members of the two libraries. Librarians from each college took turns visiting the other library and conducting peer observations of…

ARL Supplementary Statistics, 2007-2008

ERIC Educational Resources Information Center

Bland, Les, Comp.; Kyrillidou, Martha, Comp.

2009-01-01

This report presents statistics on how Association of Research Libraries (ARL) member libraries spend money on electronic resources. This report indicates that 109 ARL libraries purchased 32,329,187 electronic books. In 2007-2008, there was a median of 28,319 acquisitions of electronic books by ARL libraries (this includes one institution that…

Role of Libraries in Distance Education. SPEC Kit 216.

ERIC Educational Resources Information Center

Snyder, Carolyn A., Comp.; And Others

The Systems and Procedures Exchange Center (SPEC) surveyed 119 Association of Research Libraries (ARL) members to gather information about current distance education and distance learning initiatives in ARL libraries. The objectives of the survey were to: (1) identify libraries involved in distance education activities and determine the extent or…

Investigating the need for scholarly communications positions in Association of Academic Health Sciences Libraries member institutions

PubMed Central

Mears, Kim; Bandy, Sandra L.

2017-01-01

Background The role of health sciences librarians has expanded in the scholarly communications landscape as a result of the increase in federal public access mandates and the continued expansion of publishing avenues. This has created the need to investigate whether academic health sciences libraries should have scholarly communications positions to provide education and services exclusively related to scholarly communication topics. Methods A nine-question online survey was distributed through the Association of Academic Health Sciences Libraries (AAHSL) email discussion list to gather preliminary findings from and opinions of directors of health sciences libraries on the need for scholarly communications positions. Results The survey received a 38% response rate. The authors found that AAHSL members are currently providing scholarly communications services, and 46% of respondents expressed the need to devote a full-time position to this role. Discussion Our survey reveals a juxtaposition occurring in AAHSL member libraries. While administrators acknowledge the need to provide scholarly communications services, they often experience budget challenges in providing a full-time position for these services. PMID:28377677

Web Page Development and Management. SPEC Kit 246 and SPEC Flyer 246.

ERIC Educational Resources Information Center

Liu, Yaping Peter, Comp.

This SPEC (Systems and Procedures Exchange Center) Kit and Flyer reports results of two surveys conducted in 1996 and 1998 that examined ARL (Association of Research Libraries) member libraries' World Wide Web history, development, use, and activities. Fifty-six out of the then 119 ARL member institutions responded to the 1996 survey, and 68 out…

National Libraries' Leadership Roles and Responsibilities. Minutes of the Semiannual Meeting of the Association of Research Libraries (115th, Bethesda, Maryland, October 18-20, 1989).

ERIC Educational Resources Information Center

Harvey, Diane, Ed.

This membership meeting of the Association of Research Libraries (ARL) opened with an overview of the challenges facing research libraries and the relationships between the three U.S. national libraries and the members of ARL by Sidney Verba of Harvard University. The directors of the national libraries then spoke on their current programs and…

Views From the Pacific--Military Base Hospital Libraries in Hawaii and Guam.

PubMed

Stephenson, Priscilla L; Trafford, Mabel A; Hadley, Alice E

2016-01-01

Hospital libraries serving military bases offer a different perspective on library services. Two libraries located on islands in the Pacific Ocean provide services to active duty service men and women, including those deployed to other regions of the world. In addition, these hospital libraries serve service members' families living on the base, and often citizens from the surrounding communities.

Comparing Service Priorities between Staff and Users in Association of Research Libraries (ARL) Member Libraries

ERIC Educational Resources Information Center

Jaggars, Damon E.; Jaggars, Shanna Smith; Duffy, Jocelyn S.

2009-01-01

Using the results for participating Association of Research Libraries from the 2006 LibQUAL+[R] library service quality survey, we examine the service priorities of library staff (for example, whether desired scores for each survey item are above or below average) and the extent to which they are aligned with the priorities of undergraduates,…

Automated Synthesis of a 184-Member Library of Thiadiazepan-1, 1-dioxide-4-ones

PubMed Central

Fenster, Erik; Long, Toby R.; Zang, Qin; Hill, David; Neuenswander, Benjamin; Lushington, Gerald H.; Zhou, Aihua; Santini, Conrad; Hanson, Paul R.

2011-01-01

The construction of a 225-member (3 × 5 × 15) library of thiadiazepan-1,1-dioxide-4-ones was performed on a Chemspeed Accelerator (SLT-100) automated parallel synthesis platform, culminating in the successful preparation of 184/225 sultams. Three sultam core scaffolds were prepared based upon the utilization of an aza-Michael reaction on a multifunctional vinyl sulfonamide linchpin. The library exploits peripheral diversity in the form of a sequential, two-step [3 + 2] Huisgen cycloaddition/Pd-catalyzed Suzuki–Miyaura coupling sequence. PMID:21309582

Automated synthesis of a 184-member library of thiadiazepan-1,1-dioxide-4-ones.

PubMed

Fenster, Erik; Long, Toby R; Zang, Qin; Hill, David; Neuenswander, Benjamin; Lushington, Gerald H; Zhou, Aihua; Santini, Conrad; Hanson, Paul R

2011-05-09

The construction of a 225-member (3 × 5 × 15) library of thiadiazepan-1,1-dioxide-4-ones was performed on a Chemspeed Accelerator (SLT-100) automated parallel synthesis platform, culminating in the successful preparation of 184/225 sultams. Three sultam core scaffolds were prepared based upon the utilization of an aza-Michael reaction on a multifunctional vinyl sulfonamide linchpin. The library exploits peripheral diversity in the form of a sequential, two-step [3 + 2] Huisgen cycloaddition/Pd-catalyzed Suzuki-Miyaura coupling sequence.

Synthesis and profiling of a diverse collection of azetidine-based scaffolds for the development of CNS-focused lead-like libraries.

PubMed

Lowe, Jason T; Lee, Maurice D; Akella, Lakshmi B; Davoine, Emeline; Donckele, Etienne J; Durak, Landon; Duvall, Jeremy R; Gerard, Baudouin; Holson, Edward B; Joliton, Adrien; Kesavan, Sarathy; Lemercier, Berenice C; Liu, Haibo; Marié, Jean-Charles; Mulrooney, Carol A; Muncipinto, Giovanni; Welzel-O'Shea, Morgan; Panko, Laura M; Rowley, Ann; Suh, Byung-Chul; Thomas, Meryl; Wagner, Florence F; Wei, Jingqiang; Foley, Michael A; Marcaurelle, Lisa A

2012-09-07

The synthesis and diversification of a densely functionalized azetidine ring system to gain access to a wide variety of fused, bridged, and spirocyclic ring systems is described. The in vitro physicochemical and pharmacokinetic properties of representative library members are measured in order to evaluate the use of these scaffolds for the generation of lead-like molecules to be used in targeting the central nervous system. The solid-phase synthesis of a 1976-membered library of spirocyclic azetidines is also described.

Issues Facing Academic Library Consortia and Perceptions of Members of the Illinois Digital Academic Library.

ERIC Educational Resources Information Center

Brooks, Sam; Dorst, Thomas J.

2002-01-01

Discusses the role of consortia in academic libraries, specifically the Illinois Digital Academic Library (IDAL), and describes a study conducted by the IDAL that investigated issues surrounding full text database research including stability of content, vendor communication, embargo periods, publisher concerns, quality of content, linking and…

Academic Library Web Sites: Current Practice and Future Directions

ERIC Educational Resources Information Center

Detlor, Brian; Lewis, Vivian

2006-01-01

To address competitive threats, academic libraries are encouraged to build robust Web sites personalized to learning and research tasks. Through an evaluation of Association of Research Libraries (ARL)-member Web sites, we suggest how library Web sites should evolve and reflect upon the impacts such recommendations may have on academic libraries…

Old Skills and New Practices Mean Radical Change for Library Education

ERIC Educational Resources Information Center

Turner, Deborah; Gorichanaz, Tim

2016-01-01

Technological advances and other societal change have resulted in public libraries' increased reliance on online resources when providing access to information. However, a portion of those served by public libraries includes members of urban poor populations who may prefer to interact with information by talking. How can library educators ensure…

Wisconsin Library Trustee Reference Manual.

ERIC Educational Resources Information Center

Opinion Research Corp., Princeton, NJ.

This newly updated and revised expansion of the Wisconsin Library Trustee's Manual serves as a comprehensive resource and how-to guide for board members of public libraries that range in size and scope from small to large communities in both urban and rural areas. The manual includes basic information to which every Wisconsin library trustee…

The ARL 2030 Scenarios: A User's Guide for Research Libraries

ERIC Educational Resources Information Center

Association of Research Libraries, 2010

2010-01-01

This user's guide was developed to advance local planning at ARL member libraries. It is written for library leaders writ large and for anyone leading or contributing to research library planning processes. Users do not need advanced facilitation skills to benefit from this guide, but facilitators charged with supporting scenario planning will…

ARL Academic Health Sciences Library Statistics 2006-2007

ERIC Educational Resources Information Center

Kyrillidou, Martha, Comp.; Bland, Les, Comp.

2008-01-01

This document presents data that describe collections, expenditures, personnel, and services in 65 medical libraries at Association of Research Libraries (ARL) member institutions throughout North America. In 2006-2007, the reporting health sciences libraries held a median of 244,188 volumes, spent a total of $244,188,020, and employed 2,395 FTE…

Digital Ethnography: Library Web Page Redesign among Digital Natives

ERIC Educational Resources Information Center

Klare, Diane; Hobbs, Kendall

2011-01-01

Presented with an opportunity to improve Wesleyan University's dated library home page, a team of librarians employed ethnographic techniques to explore how its users interacted with Wesleyan's current library home page and web pages in general. Based on the data that emerged, a group of library staff and members of the campus' information…

Patron Relations: A Survival Manual.

ERIC Educational Resources Information Center

Turner, Bonnie L., Comp.; Downs, Rondi, Comp.

Recognizing the responsibility of library staff members of maintain a pleasant environment for the public in the library, this manual discusses the library user's and library employee's rights under the law and how to protect them. It is arranged alphabetically by the type of problem or emergency that may be encountered. The procedure for handling…

Management of Library Security. SPEC Kit 247 and SPEC Flyer 247.

ERIC Educational Resources Information Center

Soete, George J., Comp.; Zimmerman, Glen, Comp.

This SPEC (Systems and Procedures Exchange Center) Kit and Flyer reports results of a survey conducted in January 1999 that examined how ARL (Association of Research Libraries) member libraries assure the safety and security of persons, library materials, physical facilities, furnishings, computer equipment, etc. Forty-five of the 122 ARL member…

Studies in Public Library Government, Organization, and Support. Final Report.

ERIC Educational Resources Information Center

Garrison, Guy

This report consists of six individual reports that were done by staff members at the Library Research Center as part of the overall project. In Part I, "Financing Public Library Expansion: Case Studies of Three Defeated Bond Issue Referendums," Ruth G. Lindahl and William S. Berner analyze defeated library bond issue referendums in…

Academic Library Resource Sharing through Bibliographic Utility Program Participation.

ERIC Educational Resources Information Center

Trochim, Mary Kane

Information on the growth of bibliographic utilities and academic library networking is presented in this report, as well as profiles of interlibrary loan activity at six academic libraries who are members of a major bibliographic utility. Applications of computer technology and network participation in academic libraries, and the major events in…

A Framework for Studying Organizational Innovation in Research Libraries

ERIC Educational Resources Information Center

Jantz, Ronald C.

2012-01-01

The objective of this paper is two-fold: to propose a theoretical framework and model for studying organizational innovation in research libraries and to set forth propositions that can provide directions for future empirical studies of innovation in research libraries. Research libraries can be considered members of a class of organizations…

Library Applications of a Wide Area Network: Promoting JANET to UK Academic Libraries.

ERIC Educational Resources Information Center

MacColl, John A.

1990-01-01

Describes Project Jupiter, which was developed to promote the United Kingdom's Joint Academic Network (JANET) to its member libraries. Library uses of JANET are described, including online catalogs, commercial services, and electronic mail; the convergence of local area networks (LANs) and wide area networks (WANs) is discussed; and future…

Diversity-oriented synthesis leads to an effective class of bifunctional linchpins uniting anion relay chemistry (ARC) with benzyne reactivity

PubMed Central

Smith, Amos B.; Kim, Won-Suk

2011-01-01

In conjunction with the construction of a diversity-oriented synthesis library of 10-membered ring “natural product-like” macrolides, the design, synthesis, and validation of a unique class of bifunctional linchpins, uniting benzyne reactivity initiated by type II anion relay chemistry (ARC) has been achieved, permitting access to diverse [2+2], [3+2], and [4+2] cycloadducts. PMID:21245309

Integrating evidence-based practice and information literacy skills in teaching physical and occupational therapy students.

PubMed

Boruff, Jill T; Thomas, Aliki

2011-12-01

To ensure that physical and occupational therapy graduates develop evidence-based practice (EBP) competencies, their academic training must promote EBP skills, such as posing a clinical question and retrieving relevant literature, and the information literacy skills needed to practice these EBP skills. This article describes the collaborative process and outcome of integrating EBP and information literacy early in a professional physical therapy and occupational therapy programme. The liaison librarian and a faculty member designed an instructional activity that included a lecture, workshop and assignment that integrated EBP skills and information literacy skills in the first year of the programme. The assignment was designed to assess students' ability to conduct a search independently. The lecture and workshop were successful in their objectives, as 101 of the 104 students received at least 8 out of 10 points on the search assignment. The teaching activities developed for the students in this course appear to have achieved the goal of teaching students the EBP research cycle so that they might begin to emulate it. The collaboration between the faculty member and the librarian was integral to the success of this endeavour. Future work will include the evaluation of students' long-term retention of information literacy objectives. © 2011 The authors. Health Information and Libraries Journal © 2011 Health Libraries Group.

A Survey of the Schools of Library and Information Science in the GCC Member Nations

ERIC Educational Resources Information Center

ur Rehman, Sajjad; Al-Ansari, Husain; Yusuf, Nibal

2002-01-01

This paper describes the situation of library and information education in the six member nations of the Gulf Cooperation Council (GCC), located in the Middle East. Data were collected through a mailed instrument from six schools located in three countries of the region that offer degree programs. Five of the six programs are essentially…

Librarian-Faculty Collaboration on a Library Research Assignment and Module for College Experience Classes

ERIC Educational Resources Information Center

Keyes, Anne; Barbier, Pat

2013-01-01

A librarian and faculty member collaborated on creating a library research module for students in the faculty member's college success classes to help them learn the fundamentals of information literacy. Using the assignment "My Ideal Job," the students met four or more times with the librarian in a computer classroom to learn how to do…

Global and Information and Communication Technology (ICT) Changes in Library and Information Studies (LIS): Information Seeking Behaviors of LIS Faculty Members in Thailand

ERIC Educational Resources Information Center

Polparsi, Jomkwan

2012-01-01

This study provides an overview of Information and Communication Technology (ICT) in Library and Information Studies (LIS) education in Thailand, focusing on challenges and pressures in the information environment of Thai LIS faculty members. This study employed a qualitative research approach, naturalistic inquiry, and inductive data analysis.…

A University Libraries Faculty Perspective on the Role of the Department Head in Faculty Performance: A Grounded Theory Approach. Revised.

ERIC Educational Resources Information Center

Boden, Dana W. R.

This qualitative study examined the perceptions that university library faculty members hold regarding the role of the department head in promoting faculty growth and development. Four faculty members at the University of Nebraska-Lincoln were interviewed. Axial coding of the individuals' perceptions revealed six categories of perceived roles for…

Public Libraries as Partners in Astronomy Outreach

NASA Astrophysics Data System (ADS)

Percy, J.

2017-09-01

Public libraries have proven to be effective partners in bringing astronomy to audiences across the large and diverse city of Toronto, Canada, and enabling astronomers - both young and old - to interact with members of our community. This article reflects on the author's experience working with public libraries, especially the Toronto Public Library (TPL), the busiest public library system in the world, to deliver over forty public presentations.

Use of Online Bibliographic Retrieval Systems in Science and Technology Libraries. A Report to the Council on Library Resources on a Fellowship Project, 1977.

ERIC Educational Resources Information Center

Brown, Carolyn

This study examines the use of online bibliographic retrieval systems in a selected number of science and technology libraries chosen for their leadership reputation; it is limited to the use of online systems operated by a library staff member. Participating libraries included 12 academic, one government, and 10 research or institutional…

Grievance Procedures. SPEC Kit 23.

ERIC Educational Resources Information Center

Association of Research Libraries, Washington, DC. Office of Management Studies.

This collection of grievance procedures from member libraries of the Association of Research Libraries (ARL) contains: (1) documents on committee approaches to grievances from University of British Columbia, Center for Research Libraries, University of Connecticut, Harvard University, Michigan State University, and University of Nebraska; (2)…

Evaluation of an Inverse Molecular Design Algorithm in a Model Binding Site

PubMed Central

Huggins, David J.; Altman, Michael D.; Tidor, Bruce

2008-01-01

Computational molecular design is a useful tool in modern drug discovery. Virtual screening is an approach that docks and then scores individual members of compound libraries. In contrast to this forward approach, inverse approaches construct compounds from fragments, such that the computed affinity, or a combination of relevant properties, is optimized. We have recently developed a new inverse approach to drug design based on the dead-end elimination and A* algorithms employing a physical potential function. This approach has been applied to combinatorially constructed libraries of small-molecule ligands to design high-affinity HIV-1 protease inhibitors [M. D. Altman et al. J. Am. Chem. Soc. 130: 6099–6013, 2008]. Here we have evaluated the new method using the well studied W191G mutant of cytochrome c peroxidase. This mutant possesses a charged binding pocket and has been used to evaluate other design approaches. The results show that overall the new inverse approach does an excellent job of separating binders from non-binders. For a few individual cases, scoring inaccuracies led to false positives. The majority of these involve erroneous solvation energy estimation for charged amines, anilinium ions and phenols, which has been observed previously for a variety of scoring algorithms. Interestingly, although inverse approaches are generally expected to identify some but not all binders in a library, due to limited conformational searching, these results show excellent coverage of the known binders while still showing strong discrimination of the non-binders. PMID:18831031

Evaluation of an inverse molecular design algorithm in a model binding site.

PubMed

Huggins, David J; Altman, Michael D; Tidor, Bruce

2009-04-01

Computational molecular design is a useful tool in modern drug discovery. Virtual screening is an approach that docks and then scores individual members of compound libraries. In contrast to this forward approach, inverse approaches construct compounds from fragments, such that the computed affinity, or a combination of relevant properties, is optimized. We have recently developed a new inverse approach to drug design based on the dead-end elimination and A* algorithms employing a physical potential function. This approach has been applied to combinatorially constructed libraries of small-molecule ligands to design high-affinity HIV-1 protease inhibitors (Altman et al., J Am Chem Soc 2008;130:6099-6013). Here we have evaluated the new method using the well-studied W191G mutant of cytochrome c peroxidase. This mutant possesses a charged binding pocket and has been used to evaluate other design approaches. The results show that overall the new inverse approach does an excellent job of separating binders from nonbinders. For a few individual cases, scoring inaccuracies led to false positives. The majority of these involve erroneous solvation energy estimation for charged amines, anilinium ions, and phenols, which has been observed previously for a variety of scoring algorithms. Interestingly, although inverse approaches are generally expected to identify some but not all binders in a library, due to limited conformational searching, these results show excellent coverage of the known binders while still showing strong discrimination of the nonbinders. (c) 2008 Wiley-Liss, Inc.

Safeguarding Collections at the Dawn of the 21st Century: Describing Roles & Measuring Contemporary Preservation Activities in ARL Libraries

ERIC Educational Resources Information Center

Meyer, Lars

2009-01-01

Preservation has long been considered a fundamental responsibility of research libraries. Data on preservation activities by its members has been collected by the Association of Research Libraries (ARL) since 1987, but changing digital technologies and the research, teaching, and learning environments in which research libraries are engaged…

Spotlight on SLA Members: An Interview with Paul O'Pecko, Librarian at the Mystic Seaport G.W. Blunt White Library.

ERIC Educational Resources Information Center

Information Outlook, 1999

1999-01-01

Discusses the collection of this special library that contains materials concerning maritime commerce and related topics and is part of the Mystic Seaport Museum. Highlights include users; research; budgeting; staff; library collection size; vendors; online projects; marketing; and views on the Special Library Association. (LRW)

American Nephrology Nurses' Association

MedlinePlus

... Contact National Office ANNA Election Center Member Spotlight Leadership Board of Directors ANNA Chapter Support Team Chapter ... Opportunities Members Only ANNA Connected ANNA Open Forum Leadership Library Membership Card Member Directory Social Media Post ...

Combinatorial synthesis and hydrogenation of Mg/Al libraries prepared by electron beam physical vapor deposition.

PubMed

Garcia, Gemma; Doménech-Ferrer, Roger; Pi, Francesc; Santiso, Josep; Rodríguez-Viejo, Javier

2007-01-01

We have grown thin film libraries of the Mg-Al system using a high-throughput synthesis methodology that combines the sequential deposition of pure elements (Mg and Al) by an electron-beam (e-beam) evaporation technique and the use of a special set of moving shadow masks. This novel mask has been designed to simultaneously prepare four identical arrays of different compositions that will permit the characterization of the same library after several treatments. Wavelength dispersive spectroscopy (WDS) and micro-X-ray diffraction have been used as high-throughput screening techniques for the determination of the composition and structure of every member of the library in the as-deposited state and after hydrogenation at 1 atm of H2 during 24 h at three different temperatures: 60, 80, and 110 degrees C. We have analyzed the influence of the Mg-Al ratio on the hydrogenation of magnesium, as well as on the appearance of complex hydride phases. We have also found that aluminum can act as a catalyzer for the hydrogenation reaction of magnesium.

Educating Faculty Members on the Importance of Requiring High-Quality Information Resources at a Community College

ERIC Educational Resources Information Center

Auten, Beth; Glauner, Dana; Lefoe, Grant; Henry, Jo

2016-01-01

This article explains how the South Piedmont Community College librarians educated faculty members about how they guide student use of the library and how it is advantageous for them to require high-quality resources for student papers. As documented by observations at SPCC and in the library literature, students use the tools they know to find…

Pop-up exhibits as an outreach tool: Connecting academic and public audiences with library resources

NASA Astrophysics Data System (ADS)

Powell, S.; Teplitzky, S.

2016-12-01

Subject specialty libraries like the Earth Sciences and Map Library at UC Berkeley thrive on active user communities, but promoting awareness of resources and services can be slow and time-consuming. In Fall 2014, two new librarians there introduced a series of monthly pop-up exhibits called "Maps and More" in order to help build that community. Now in their third year, the show-and-tell sessions are designed to lure visitors into the library and spark new connections among students, researchers and librarians, and renewed engagement with library collections. The librarians surveyed participants in spring 2015 and fall 2016 to assess the impact of "Maps and More" in terms of visitors' perception of the events and awareness of library services and materials. One significant finding from the spring 2015 survey is that a quarter of respondents had never been to the Earth Sciences and Map Library before the session. The exhibits draw in participants from a range of departments, including significant numbers from Seismology, Earth and Planetary Science, Geography, as well as members of the public. Sessions held on Cal Day - the university's annual public open house with 30-40,000 public visitors - were particularly good outreach experiences. Partnerships with other units have great potential for expanding the reach of these events. The Maps and More exhibits have proven to be a successful outreach tool for raising the profile of the library collections and services and helping users understand maps as research materials.

Acquisition Policies. SPEC Kit 12.

ERIC Educational Resources Information Center

Association of Research Libraries, Washington, DC. Office of Management Studies.

This collection of acquisition materials from member libraries of the Association of Research Libraries (ARL) contains: (1) acquisition policies from Brigham Young University, Iowa State University, and the University of Cincinnati; (2) book selection policies from the University of Nebraska Undergraduate Library and Georgetown University; (3) an…

Partnering with libraries to promote walking among community-dwelling adults: a Kingston gets active pilot pedometer-lending project.

PubMed

Ryder, Holly H; Faloon, Kathryn J; Lévesque, Lucie; McDonald, Deanna

2009-10-01

Most adults do not walk enough to obtain health benefits. Pedometers have been successfully utilized to motivate and increase walking. Given that libraries are a place where community members seek health resources, they are a logical setting for increasing community accessibility to pedometers. The purpose was to examine the feasibility of lending pedometers to library patrons to increase walking. In five Canadian public libraries, 90 pedometers were made available for 6 months. A total of 41 library patrons (33 women, 8 men, age range 18 to 65 or older) completed a survey about their walking patterns and pedometer use. More than 330 loans were made. Chisquare analysis found significant associations between walking and motivation to walk more (p < .05), walking and goal setting (p < .05), and motivation to walk more and setting a walking goal (p < .001). Results provide preliminary evidence that lending pedometers through local libraries is an effective, low-cost approach to enhance walking in community members.

Lead Diversification through a Prins-Driven Macrocyclization Strategy: Application to C13-Diversified Bryostatin Analogues.

PubMed

Wender, Paul A; Billingsley, Kelvin L

2013-01-01

The design, synthesis, and biological evaluation of a novel class of C13-diversified bryostatin analogues are described. An innovative and general strategy based on a Prins macrocyclization-nucleophilic trapping cascade was used to achieve late-stage diversification. In vitro analysis of selected library members revealed that modification at the C13 position of the bryostatin scaffold can be used as a diversification handle to regulate biological activity.

Rapid access to compound libraries through flow technology: fully automated synthesis of a 3-aminoindolizine library via orthogonal diversification.

PubMed

Lange, Paul P; James, Keith

2012-10-08

A novel methodology for the synthesis of druglike heterocycle libraries has been developed through the use of flow reactor technology. The strategy employs orthogonal modification of a heterocyclic core, which is generated in situ, and was used to construct both a 25-membered library of druglike 3-aminoindolizines, and selected examples of a 100-member virtual library. This general protocol allows a broad range of acylation, alkylation and sulfonamidation reactions to be performed in conjunction with a tandem Sonogashira coupling/cycloisomerization sequence. All three synthetic steps were conducted under full automation in the flow reactor, with no handling or isolation of intermediates, to afford the desired products in good yields. This fully automated, multistep flow approach opens the way to highly efficient generation of druglike heterocyclic systems as part of a lead discovery strategy or within a lead optimization program.

Provision of Computer Printing Capabilities to Library Patrons. SPEC Kit 183.

ERIC Educational Resources Information Center

Taylor, Suzanne; Welch, C. Brigid, Ed.

1992-01-01

This publication reports on the results of a 1992 survey of 80 Association of Research Libraries (ARL) member libraries on their use of printers for recording references found in online public access catalog (OPAC) and CD-ROM searches. As was found in a 1990 survey on the same topic, only a small proportion of libraries reported that they charged…

"1st Reads" Program Aims to Improve Book Donations and Processes

ERIC Educational Resources Information Center

Coffman, Steve

2006-01-01

Many people donate books to libraries, but too often they are titles that the librarians cannot use because they are usually too old, too passe, or too tattered and worn to be added to the library collection, and so they end up in library sales. Librarians in Riverside County, California and members of the Library Systems & Services, LLC (LSSI)…

How Academic Libraries Help Faculty Teach and Students Learn: The 2005 Colorado Academic Library Impact Study. A Closer Look

ERIC Educational Resources Information Center

Dickenson, Don

2006-01-01

This study examined academic library usage and outcomes. The objective of the study was to understand how academic libraries help students learn and assist faculty with teaching and research. From March to May 2005, nine Colorado institutions administered two online questionnaires--one to undergraduate students and another to faculty members who…

Improving Usage Statistics Processing for a Library Consortium: The Virtual Library of Virginia's Experience

ERIC Educational Resources Information Center

Matthews, Tansy E.

2009-01-01

This article describes the development of the Virtual Library of Virginia (VIVA). The VIVA statistics-processing system remains a work in progress. Member libraries will benefit from the ability to obtain the actual data from the VIVA site, rather than just the summaries, so a project to make these data available is currently being planned. The…

Getting the Books Off the Shelves. Making the Most of Your Congregation's Library. Revised Edition. CSLA Guide No. 12.

ERIC Educational Resources Information Center

Smith, Ruth S.

This guide provides guidelines for promoting and attracting users to a church library. The first of six chapters, "Promoting Library Use," discusses stages of promotion, methods of attracting the attention and interest of prospective users, and how to involve members of the congregation in library activities; the second chapter, "Publicizing the…

Separate but Equal? A Comparison of Content on Library Web Pages and Their Text Versions

ERIC Educational Resources Information Center

Hazard, Brenda L.

2008-01-01

This study examines the Web sites of the Association of Research Libraries member libraries to determine the presence of a separate text version of the default graphical homepage. The content of the text version and the homepage is compared. Of 121 Web sites examined, twenty libraries currently offer a text version. Ten sites maintain wholly…

Communication, Collaboration and Cooperation: An Evaluation of Nova Scotia's Borrow Anywhere, Return Anywhere (BARA) Multi-Type Library Initiative

ERIC Educational Resources Information Center

van den Hoogen, Suzanne; Parrott, Denise

2012-01-01

Partnerships and collaborations among libraries are proven to enhance collective resources. The collaboration of multi-type libraries offers a unique opportunity to explore the potential of different libraries working together to provide the best possible service to their community members. This article provides a detailed report of a multi-type…

School Library Snapshots: A Brief Survey of Illinois School Library Collections in Three Areas of Science.

ERIC Educational Resources Information Center

Illinois School Library Media Association, Fairfield.

To study the strengths and weaknesses of Illinois school library collections in science and to quantify the need for increased funding for collection development, a survey was completed by over 400 members of the Illinois School Library Media Association. Topics of interest were astronomy, space, the solar system, general biology, ecology, human…

Clustering of disulfide-rich peptides provides scaffolds for hit discovery by phage display: application to interleukin-23.

PubMed

Barkan, David T; Cheng, Xiao-Li; Celino, Herodion; Tran, Tran T; Bhandari, Ashok; Craik, Charles S; Sali, Andrej; Smythe, Mark L

2016-11-23

Disulfide-rich peptides (DRPs) are found throughout nature. They are suitable scaffolds for drug development due to their small cores, whose disulfide bonds impart extraordinary chemical and biological stability. A challenge in developing a DRP therapeutic is to engineer binding to a specific target. This challenge can be overcome by (i) sampling the large sequence space of a given scaffold through a phage display library and by (ii) panning multiple libraries encoding structurally distinct scaffolds. Here, we implement a protocol for defining these diverse scaffolds, based on clustering structurally defined DRPs according to their conformational similarity. We developed and applied a hierarchical clustering protocol based on DRP structural similarity, followed by two post-processing steps, to classify 806 unique DRP structures into 81 clusters. The 20 most populated clusters comprised 85% of all DRPs. Representative scaffolds were selected from each of these clusters; the representatives were structurally distinct from one another, but similar to other DRPs in their respective clusters. To demonstrate the utility of the clusters, phage libraries were constructed for three of the representative scaffolds and panned against interleukin-23. One library produced a peptide that bound to this target with an IC 50 of 3.3 μM. Most DRP clusters contained members that were diverse in sequence, host organism, and interacting proteins, indicating that cluster members were functionally diverse despite having similar structure. Only 20 peptide scaffolds accounted for most of the natural DRP structural diversity, providing suitable starting points for seeding phage display experiments. Through selection of the scaffold surface to vary in phage display, libraries can be designed that present sequence diversity in architecturally distinct, biologically relevant combinations of secondary structures. We supported this hypothesis with a proof-of-concept experiment in which three phage libraries were constructed and panned against the IL-23 target, resulting in a single-digit μM hit and suggesting that a collection of libraries based on the full set of 20 scaffolds increases the potential to identify efficiently peptide binders to a protein target in a drug discovery program.

ODIN. Online Database Information Network: ODIN Policy & Procedure Manual.

ERIC Educational Resources Information Center

Townley, Charles T.; And Others

Policies and procedures are outlined for the Online Database Information Network (ODIN), a cooperative of libraries in south-central Pennsylvania, which was organized to improve library services through technology. The first section covers organization and goals, members, and responsibilities of the administrative council and libraries. Patrons…

Emotional Intelligence in Library Disaster Response Assistance Teams: Which Competencies Emerged?

ERIC Educational Resources Information Center

Wilkinson, Frances C.

2015-01-01

This qualitative study examines the relationship between emotional intelligence competencies and the personal attributes of library disaster response assistance team (DRAT) members. Using appreciative inquiry protocol to conduct interviews at two academic libraries, the study presents findings from emergent thematic coding of interview…

Social inclusion and the City of Swan public libraries in Western Australia.

PubMed

Lockyer-Benzie, Maureena

2004-09-01

The focus of this paper is on an understanding of social exclusion/inclusion: the concept and how a specific public library service, namely the City of Swan Public Library service, has responded to this social issue. The terms social inclusion/exclusion are explored and clarified from an international, Western Australian State Government, and public library perspective. This is followed by a brief overview of Western Australia as an Australian state, and how public libraries operate based on a partnership with the State Library of Western Australia and Local Government. The City of Swan Public Libraries are described in some depth and also portrayed in their local setting namely the City of Swan, a city of extensive growth that offers a unique environment of both rural and urban areas. The concept of social inclusion is then applied to the City of Swan Public Library service and how the library service addresses social inclusion within its physical environment, policies, operations, future planning, programmes and services. This includes the results of a Library Non-user Survey that was conducted in 2001. The aims of this survey were to: ascertain why non-users within the City of Swan do not make use of the library facilities; explore why past members were not using the library services; examine the effectiveness of library promotions; and investigate the access to and usage of the Internet. The paper concludes with a list of the potential social conditions of which public libraries need to be aware in their strategic planning activities so that community members are not excluded from participating and accessing the public library service.

Library Operations Policies and Procedures, Volume 2. Central Archive for Reusable Defense Software (CARDS)

DTIC Science & Technology

1994-02-28

improvements. Pare 10 ka•- V •DkI U Release Manager The Release Manager provides franchisees with media copies of existing libraries, as needed. Security...implementors, and potential library franchisees . Security Team The Security Team assists the Security Officer with security analysis. Team members are...and Franchisees . A Potential User is an individual who requests a Library Account. A User Recruit has been sent a CARDS Library Account Registration

ARL Annual Salary Survey, 2009-2010

ERIC Educational Resources Information Center

Kyrillidou, Martha, Comp.; Bland, Les, Comp.

2010-01-01

The "ARL Annual Salary Survey 2009-2010" reports salary data for all professional staff working in ARL libraries. The Association of Research Libraries (ARL) represents the interests of libraries that serve major North American research institutions. Data for 10,207 professional staff members were reported this year for the 114 ARL…

ARL Annual Salary Survey, 2008-2009

ERIC Educational Resources Information Center

Kyrillidou, Martha, Comp.; Bland, Les, Comp.

2009-01-01

The "ARL Annual Salary Survey, 2008-2009" reports salary data for all professional staff working in ARL libraries. The Association of Research Libraries (ARL) represents the interests of libraries that serve major North American research institutions. Data for 10,148 professional staff members were reported this year for the 113 ARL…

An Analysis of Academic Research Libraries Assessment Data: A Look at Professional Models and Benchmarking Data

ERIC Educational Resources Information Center

Lewin, Heather S.; Passonneau, Sarah M.

2012-01-01

This research provides the first review of publicly available assessment information found on Association of Research Libraries (ARL) members' websites. After providing an overarching review of benchmarking assessment data, and of professionally recommended assessment models, this paper examines if libraries contextualized their assessment…

Numeric Data Products and Services. SPEC Kit.

ERIC Educational Resources Information Center

Cook, Michael N., Comp.; Hernandez, John J., Comp.; Nicholson, Shawn, Comp.

2001-01-01

This SPEC (Systems and Procedures Exchange Center) Kit presents the results of a survey of Association of Research Libraries (ARL) member libraries. The survey addressed the following questions about numeric data (i.e., any information resource, print or non-print, with considerable numeric content) in academic libraries: (1) What relationships…

Resource Notebook on Staff Development.

ERIC Educational Resources Information Center

Sitts, Maxine K., Ed.

Based on the comprehensive library self-study method developed by the Association of Research Libraries' (ARL) Office of Management Studies (OMS) and first used as the Management Review and Analysis Project (MRAP), this resource notebook presents surveys and diagnostic aids, OMS self-study reports, and ARL member library documents related to…

Recommended Procedures for the Internal Financial Auditing of University Libraries.

ERIC Educational Resources Information Center

Kurth, William H.; Zubatsky, David S.

This study develops a generalized procedure for the internal financial auditing of university libraries. It identifies critical internal control points in library operations, and develops questions to measure and evaluate fiscal operations effectiveness. Auditing data and advice were gathered from a survey of 87 members of the Association of…

Consortium Purchases: Case Study for a Cost-Benefit Analysis.

ERIC Educational Resources Information Center

Scigliano, Marisa

2002-01-01

Discusses library cooperation and academic library consortia and presents a case study of a Canadian consortia that conducted a cost-benefit analysis for purchasing an electronic resource. Reports on member library subscription costs, external economic factors, value of patron time saved, costs and benefits for patrons, and net savings. (LRW)

ARL Supplementary Statistics, 2006-2007

ERIC Educational Resources Information Center

Bland, Les, Comp.; Kyrillidou, Martha, Comp.

2009-01-01

This report presents statistics on how Association of Research Libraries (ARL) member libraries spend money on electronic resources. This report indicates that 108 ARL libraries purchased 25,006,758 electronic books. In 2006-2007, there was an ARL median of 243,725 acquisitions of electronic books (this includes one institution that purchased…

Comparative characterization of random-sequence proteins consisting of 5, 12, and 20 kinds of amino acids

PubMed Central

Tanaka, Junko; Doi, Nobuhide; Takashima, Hideaki; Yanagawa, Hiroshi

2010-01-01

Screening of functional proteins from a random-sequence library has been used to evolve novel proteins in the field of evolutionary protein engineering. However, random-sequence proteins consisting of the 20 natural amino acids tend to aggregate, and the occurrence rate of functional proteins in a random-sequence library is low. From the viewpoint of the origin of life, it has been proposed that primordial proteins consisted of a limited set of amino acids that could have been abundantly formed early during chemical evolution. We have previously found that members of a random-sequence protein library constructed with five primitive amino acids show high solubility (Doi et al., Protein Eng Des Sel 2005;18:279–284). Although such a library is expected to be appropriate for finding functional proteins, the functionality may be limited, because they have no positively charged amino acid. Here, we constructed three libraries of 120-amino acid, random-sequence proteins using alphabets of 5, 12, and 20 amino acids by preselection using mRNA display (to eliminate sequences containing stop codons and frameshifts) and characterized and compared the structural properties of random-sequence proteins arbitrarily chosen from these libraries. We found that random-sequence proteins constructed with the 12-member alphabet (including five primitive amino acids and positively charged amino acids) have higher solubility than those constructed with the 20-member alphabet, though other biophysical properties are very similar in the two libraries. Thus, a library of moderate complexity constructed from 12 amino acids may be a more appropriate resource for functional screening than one constructed from 20 amino acids. PMID:20162614

Cataloging Before and After OCLC. Illinois Valley Library System OCLC Experimental Project. Report No. 3.

ERIC Educational Resources Information Center

Bills, Linda G.

A project was conducted from 1980 to 1982 to determine the costs and benefits of OCLC use in 29 small and medium-sized member libraries of the Illinois Valley Library System (IVLS). Academic, school, public, and special libraries participated by recording the time and staffing levels used for and the cost of OCLC and pre-OCLC cataloging (by…

Acoustic Neuroma Educational Video

MedlinePlus Videos and Cool Tools

... Library Patient Info Booklets Member Login Research ANA Survey/Registry AN Research Patient Registry Other Caregivers Public ... Newsletter Library Patient Info Booklets Research Back ANA Survey/Registry AN Research Back Keck Medicine of USC ...

Standards for the academic veterinary medical library

PubMed Central

Murphy, Sarah Anne; Bedard, Martha A.; Crawley-Low, Jill; Fagen, Diane; Jette, Jean-Paul

2005-01-01

The Standards Committee of the Veterinary Medical Libraries Section was appointed in May 2000 and charged to create standards for the ideal academic veterinary medical library, written from the perspective of veterinary medical librarians. The resulting Standards for the Academic Veterinary Medical Library were approved by members of the Veterinary Medical Libraries Section during MLA '03 in San Diego, California. The standards were approved by Section Council in April 2005 and received final approval from the Board of Directors of the Medical Library Association during MLA '04 in Washington, DC. PMID:15685288

The Impact of Library Resources and Services on the Scholarly Activity of Medical Faculty and Residents.

PubMed

Quesenberry, Alexandria C; Oelschlegel, Sandy; Earl, Martha; Leonard, Kelsey; Vaughn, Cynthia J

2016-01-01

Librarians at an academic medical center library gathered data to determine if library services and resources impacted scholarly activity. A survey was developed and sent out to faculty and residents asking how they used the library during scholarly activity. Sixty-five faculty members and residents responded to the survey. The majority of respondents involved with scholarly activity use the library's services and resources. PubMed is the most frequently used database. The positive results show the library impacts the scholarly activity of medical faculty and residents.

The Medical Library Association Benchmarking Network: results.

PubMed

Dudden, Rosalind Farnam; Corcoran, Kate; Kaplan, Janice; Magouirk, Jeff; Rand, Debra C; Smith, Bernie Todd

2006-04-01

This article presents some limited results from the Medical Library Association (MLA) Benchmarking Network survey conducted in 2002. Other uses of the data are also presented. After several years of development and testing, a Web-based survey opened for data input in December 2001. Three hundred eighty-five MLA members entered data on the size of their institutions and the activities of their libraries. The data from 344 hospital libraries were edited and selected for reporting in aggregate tables and on an interactive site in the Members-Only area of MLANET. The data represent a 16% to 23% return rate and have a 95% confidence level. Specific questions can be answered using the reports. The data can be used to review internal processes, perform outcomes benchmarking, retest a hypothesis, refute a previous survey findings, or develop library standards. The data can be used to compare to current surveys or look for trends by comparing the data to past surveys. The impact of this project on MLA will reach into areas of research and advocacy. The data will be useful in the everyday working of small health sciences libraries as well as provide concrete data on the current practices of health sciences libraries.

The Medical Library Association Benchmarking Network: results*

PubMed Central

Dudden, Rosalind Farnam; Corcoran, Kate; Kaplan, Janice; Magouirk, Jeff; Rand, Debra C.; Smith, Bernie Todd

2006-01-01

Objective: This article presents some limited results from the Medical Library Association (MLA) Benchmarking Network survey conducted in 2002. Other uses of the data are also presented. Methods: After several years of development and testing, a Web-based survey opened for data input in December 2001. Three hundred eighty-five MLA members entered data on the size of their institutions and the activities of their libraries. The data from 344 hospital libraries were edited and selected for reporting in aggregate tables and on an interactive site in the Members-Only area of MLANET. The data represent a 16% to 23% return rate and have a 95% confidence level. Results: Specific questions can be answered using the reports. The data can be used to review internal processes, perform outcomes benchmarking, retest a hypothesis, refute a previous survey findings, or develop library standards. The data can be used to compare to current surveys or look for trends by comparing the data to past surveys. Conclusions: The impact of this project on MLA will reach into areas of research and advocacy. The data will be useful in the everyday working of small health sciences libraries as well as provide concrete data on the current practices of health sciences libraries. PMID:16636703

Library Publications Programs. SPEC Kit 145.

ERIC Educational Resources Information Center

Knudsen, Monica L.

Based on a two-phase survey of 118 Association of Research Libraries member libraries which was conducted between November 1987 and January 1988, this report begins with an overview of the responses from 16 respondents who indicated that they had a centralized approach to publishing. Areas studied include the nature of centralized programs,…

Relationship of Technology and Characteristics of Library Functional Units.

ERIC Educational Resources Information Center

Lynch, Beverly P.; Verdin, Jo Ann

The project summarized in this report collected data from 3 of the 25 largest Association of Research Library (ARL) member libraries in order to: (1) examine the durability of the measure of technology set forth in "An Empirical Assessment of Perrow's Technology Construct" (Administrative Science Quarterly, 1974, pp. 338-356); (2) study…

Use of Management Statistics in ARL Libraries. SPEC Kit #153.

ERIC Educational Resources Information Center

Vasi, John

A Systems and Procedures Exchange Center (SPEC) survey conducted in 1986 investigated the collection and use of management statistics in Association of Research Libraries (ARL) member libraries, and SPEC Kit #134 (May 1987) summarized the kinds of statistics collected and the reasons given by the 91 respondents for collecting them. This more…

Spokane Community College Library Public Services Handbook. (Interlibrary Loans).

ERIC Educational Resources Information Center

Waesche, Betty; McLane, Sara

General and specific interlibrary loan (ILL) policies and procedures used by this library are described, as well as the duties and responsibilities of library staff members who work with interlibrary loans. Included are locally developed forms for in-person and phone requests, handouts, a flowchart of the procedures followed when an interlibrary…

Photocopy Services in ARL Libraries. SPEC Kit 115.

ERIC Educational Resources Information Center

McCool, Donna L.

To gather information about the nature of photocopy services in academic libraries and issues relating to their management, a survey was mailed to each of the 117 members of the Association for Research Libraries (ARL). The survey focused on two components of photocopy services: the self-service copiers placed at strategic locations within the…

Managing Library Volunteers, Second Edition

ERIC Educational Resources Information Center

Driggers, Preston; Dumas, Eileen

2011-01-01

Volunteers are essential to a successful library program--and at a time when deep budget cuts are the norm, there are many libraries that depend on the help of dedicated volunteers, who do everything from shelving books to covering the phones. Whether these are friends, trustees, or community members, managing them effectively is the key to…

Model Preservation Program for a Small University Library.

ERIC Educational Resources Information Center

Robbins, Louise S.

This report proposes a preservation program assuming a model of a university library serving 5,000 or fewer students and 350 or fewer faculty members. The model program is not for a comprehensive university or research institution, and the library's collection is one developed and used as a curriculum-support collection. The goal of the…

Unwrapping the Bundle: An Examination of Research Libraries and the "Big Deal"

ERIC Educational Resources Information Center

Strieb, Karla L.; Blixrud, Julia C.

2014-01-01

This study presents and analyzes the findings of a 2012 survey of member libraries belonging to the Association of Research Libraries (ARL) about publishers' large journal bundles and compares the results to earlier surveys. The data illuminate five research questions: market penetration, journal bundle construction, collection format shifts,…

Academic Library Resource Sharing through Bibliographic Utility Program Participation. Executive Summary.

ERIC Educational Resources Information Center

Trochim, Mary Kane

This summary briefly outlines a separate report containing information on the growth of bibliographic utilities and academic library networking, as well as profiles of interlibrary loan activity at six academic libraries who are members or users of a major bibliographic utility. Applications of computer technology and network participation in…

Malta Library Association Year Book 1971.

ERIC Educational Resources Information Center

Bonavia, Carmel G. Ed.; And Others

The scope of this yearbook is that of the Malta Library Association (MLA) itself, namely, the libraries and librarians of the Maltese Islands. This first issue of the MLA Yearbook contains the following information: (1) officers of the association; (2) the MLA constitution; (3) a list of members; (4) the first and second annual reports delivered…

Probing the dynamic reversibility and generation of dynamic combinatorial libraries in the presence of bacterial model oligopeptides as templating guests of tetra-carbohydrazide macrocycles using electrospray mass spectrometry.

PubMed

Nour, Hany F; Islam, Tuhidul; Fernández-Lahore, Marcelo; Kuhnert, Nikolai

2012-12-30

Over the past few decades, bacterial resistance to antibiotics has emerged as a real threat to human health. Accordingly, there is an urgent demand for the development of innovative strategies for discovering new antibiotics. We present the first use of tetra-carbohydrazide cyclophane macrocycles in dynamic combinatorial chemistry (DCC) and molecular recognition as chiral hosts binding oligopeptides, which mimic bacterial cell wall. This study introduces an innovative application of electrospray ionisation time-of-flight mass spectrometry (ESI-TOF MS) to oligopeptides recognition using DCC. A small dynamic library composed of eight functionalised macrocycles has been generated in solution and all members were characterised by ESI-TOF MS. We also probed the dynamic reversibility and mechanism of formation of tetra-carbohydrazide cyclophanes in real-time using ESI-TOF MS. Dynamic reversibility of tetra-carbohydrazide cyclophanes is favored under thermodynamic control. The mechanism of formation of tetra-carbohydrazide cyclophanes involves key dialdehyde intermediates, which have been detected and assigned according to their high-resolution m/z values. Three members of the dynamic library bind efficiently in the gas phase to a selection of oligopeptides, unique to bacteria, allowing observation of host/guest complex ions in the gas phase. We probed the mechanism of the [2+2]-cyclocondensation reaction forming library members, proved dynamic reversibility of tetra-carbohydrazide cyclophanes and showed that complex ions formed between library members and hosts can be observed in the gas phase, allowing the solution of an important problem of biological interest. Copyright © 2012 John Wiley & Sons, Ltd.

Design and Synthesis of a Library of Tetracyclic Hydroazulenoisoindoles

PubMed Central

Brummond, Kay M.; Mao, Shuli; Shinde, Sunita N.; Johnston, Paul J.; Day, Billy W.

2009-01-01

Forty-four tetracyclic hydroazulenoisoindoles were synthesized via a tandem cyclopropanation/Cope rearrangement followed by a Diels-Alder sequence from easily available five-membered cyclic cross-conjugated trienones. These trienones were obtained from two different routes depending upon whether R1 and R2 are alkyl or amino acid derived functional groups, via a rhodium(I)-catalyzed cycloisomerization reaction. In order to increase diversity, four maleimides and two 1,2,4-triazoline-3,5-diones were used as dienophiles in the Diels-Alder step. Several Diels-Alder adducts were further reacted under palladium-catalyzed hydrogenation conditions, leading to a diastereoselective reduction of the trisubstituted double bond. This library has demonstrated rapid access to a variety of structurally complex natural product-like compounds via stereochemical diversity and building block diversity approaches. PMID:19366169

Making Choices, Taking Chances, Facing Challenges, Managing Change: The Implementation of a Voice/Video/Data Network at the Alliance Library System.

ERIC Educational Resources Information Center

Wilford, Valerie J.; Logan, Lee; Bell, Lori; Cloyes, Kay

The Alliance Library System (ALS) is one of 12 regional library systems in Illinois, providing a full spectrum of support services for 300 member libraries of all types (public, school, academic, and special) located in west central Illinois. This paper describes the process by which ALS implemented a voice/video/data network connecting their four…

Initial Special Reports Submitted by Member States on the Action Taken by Them Upon the Recommendation Concerning the International Standardization of Library Statistics, Adopted by the General Conference During its Sixteenth Session. Item 21 of the Provisional Agenda.

ERIC Educational Resources Information Center

United Nations Educational, Scientific, and Cultural Organization, Paris (France).

Reports, some only partial, from the member states regarding their action on the topic of international standards for library statistics are presented. The 22 countries represented in this report are: Brazil, Bulgaria, Canada, Cyprus, Cuba, Dahomey, Denmark, Finland, France, Federal Republic of Germany, India, Israel, Japan, Libya, Nepal,…

Health information-seeking behavior and older African American women.

PubMed Central

Gollop, C J

1997-01-01

This study explored the ways in which urban, older, African American women obtain health information and some of the factors that influence such activity. Among the possible determinants examined were self-perceived literacy, access to health information, and mobility. The findings suggest that respondents receive health information from their physicians, the mass media, and members of their social networks. The results of this research also indicated that members of this population have a highly positive perception of the public library, although only a small segment use the library regularly, and that it may be in the interest of the library to investigate the role it could play in providing health information to older adults. PMID:9160150

Health information-seeking behavior and older African American women.

PubMed

Gollop, C J

1997-04-01

This study explored the ways in which urban, older, African American women obtain health information and some of the factors that influence such activity. Among the possible determinants examined were self-perceived literacy, access to health information, and mobility. The findings suggest that respondents receive health information from their physicians, the mass media, and members of their social networks. The results of this research also indicated that members of this population have a highly positive perception of the public library, although only a small segment use the library regularly, and that it may be in the interest of the library to investigate the role it could play in providing health information to older adults.

Interlibrary Loan in ARL Libraries. SPEC Kit 92.

ERIC Educational Resources Information Center

Association of Research Libraries, Washington, DC. Office of Management Studies.

During the summer of 1982, the Association of Research Libraries (ARL) surveyed its members regarding their interlibrary loan (ILL) traffic and procedures. A response rate of 97% (110 out of 113 libraries surveyed) was obtained. The survey concentrated on loan charges and changes since a similar l976-77 survey. It was found that 33% of respondents…

76 FR 21043 - Notice of Public Meeting: Technical Aspects of Mandatory Deposit of Published Electronic Works...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-14

... LIBRARY OF CONGRESS Copyright Office [Docket No. 2011-3] Notice of Public Meeting: Technical... Office, Library of Congress. ACTION: Notice of public meeting. SUMMARY: The U.S. Copyright Office of the Library of Congress will host a public meeting on May 24, 2011, with members of the publishing community...

Improving the Virtual Reference Experience: How Closely Do Academic Libraries Adhere to RUSA Guidelines?

ERIC Educational Resources Information Center

Platt, Jessica; Benson, Pete

2010-01-01

The purpose of this study was to measure the degree to which academic libraries or library staff members throughout the United States adhere to the Guidelines for Virtual Reference Services provided by the Reference & User Services Association (RUSA). The results of the study were analyzed to identify specific areas where improvement is needed…

Developing a Content Strategy for an Academic Library Website

ERIC Educational Resources Information Center

Blakiston, Rebecca

2013-01-01

Academic library websites contain a vast amount of complex content and, all too often, there is a lack of established process for creating, updating, and deleting that content. There is no clear vision or purpose to the content, and numerous staff members are expected to maintain content with little guidance. Because of this, many library websites…

Preparation and Presentation of the Library Budget. SPEC Kit 32.

ERIC Educational Resources Information Center

Association of Research Libraries, Washington, DC. Office of Management Studies.

This kit on the preparation and presentation of the library budget in Association of Research Libraries (ARL) institutions contains a concise summary of the results of a 1977 member survey on budget preparation and eight related primary source documents. The summary of the Systems and Procedures Exchange Center (SPEC) survey focuses on types of…

Changing Patterns in Internal Communication in Large Academic Libraries. Occasional Paper Number 6.

ERIC Educational Resources Information Center

Euster, Joanne R.

Based on data from a 1979 survey of ARL member libraries, this study by the Office of Management Studies analyzes the responses of selected libraries which had provided internal studies or planning documents on the subject of internal communication and notes the extent of resulting changes in procedures. The studies yielded information on staff…

"Hey! Look At Me!" or Five Easy Ways To Promote Your Library, Your Services, and Yourself.

ERIC Educational Resources Information Center

Schank, Susan Knelb

2002-01-01

Suggest five ways for promoting school library media centers. Discusses the use of e-mail for communicating with teachers and staff; school newsletters for communicating with parents and students; involving community members; showing new library materials at staff development meetings; and booktalks using older books as well as new titles. (LRW)

Report of Library Services and Construction Act Project #2842, January 1-June 30, 1966.

ERIC Educational Resources Information Center

Los Angeles Public Library, CA.

This report covers the first six months of the Los Angeles Public Library's federally funded project to extend library service to the disadvantaged. Section I covers the recruitment and training of staff members for the project, including monthly staff orientation meetings emphasizing technical and sensitivity training. Section II describes the…

Upgrading a ColdFusion-Based Academic Medical Library Staff Intranet

ERIC Educational Resources Information Center

Vander Hart, Robert; Ingrassia, Barbara; Mayotte, Kerry; Palmer, Lisa A.; Powell, Julia

2010-01-01

This article details the process of upgrading and expanding an existing academic medical library intranet to include a wiki, blog, discussion forum, and photo collection manager. The first version of the library's intranet from early 2002 was powered by ColdFusion software and existed primarily to allow staff members to author and store minutes of…

Cline Library Surveys of the NAU Faculty and Students, and Users of Media Services and Field Services, and Evaluations of the Desk Services Provided by Media Services and Special Collections and Archives.

ERIC Educational Resources Information Center

Mullen, Melissa J.; And Others

Results are presented from surveys conducted at Northern Arizona University (NAU) about its library services. Mail survey questionnaires were completed by 266 faculty members, and a telephone survey questioned 400 students about library services at the university's Cline Library. A mail survey completed by 121 media service users and 126 field…

A Barcoding Strategy Enabling Higher-Throughput Library Screening by Microscopy.

PubMed

Chen, Robert; Rishi, Harneet S; Potapov, Vladimir; Yamada, Masaki R; Yeh, Vincent J; Chow, Thomas; Cheung, Celia L; Jones, Austin T; Johnson, Terry D; Keating, Amy E; DeLoache, William C; Dueber, John E

2015-11-20

Dramatic progress has been made in the design and build phases of the design-build-test cycle for engineering cells. However, the test phase usually limits throughput, as many outputs of interest are not amenable to rapid analytical measurements. For example, phenotypes such as motility, morphology, and subcellular localization can be readily measured by microscopy, but analysis of these phenotypes is notoriously slow. To increase throughput, we developed microscopy-readable barcodes (MiCodes) composed of fluorescent proteins targeted to discernible organelles. In this system, a unique barcode can be genetically linked to each library member, making possible the parallel analysis of phenotypes of interest via microscopy. As a first demonstration, we MiCoded a set of synthetic coiled-coil leucine zipper proteins to allow an 8 × 8 matrix to be tested for specific interactions in micrographs consisting of mixed populations of cells. A novel microscopy-readable two-hybrid fluorescence localization assay for probing candidate interactions in the cytosol was also developed using a bait protein targeted to the peroxisome and a prey protein tagged with a fluorescent protein. This work introduces a generalizable, scalable platform for making microscopy amenable to higher-throughput library screening experiments, thereby coupling the power of imaging with the utility of combinatorial search paradigms.

Librarian instruction-delivery modality preferences for professional continuing education

PubMed Central

Lynn, Valerie A.; Bose, Arpita; Boehmer, Susan J.

2010-01-01

Objectives: Attending professional continuing education (CE) is an important component of librarianship. This research study identified librarians' preferences in delivery modalities of instruction for professional CE. The study also identified influential factors associated with attending CE classes. Methods: Five instruction-delivery modalities and six influential factors were identified for inclusion in an online survey. The survey completed by members of the American Library Association (ALA), Special Libraries Association (SLA), and Medical Library Association (MLA) provided the data for analysis of librarian preferences and influential factors. Results: The majority of respondents were MLA members, followed by ALA and SLA members. Librarians from all three library associations preferred the face-to-face instructional modality. The most influential factor associated with the decision to attend a professional CE class was cost. Conclusions: All five instruction-delivery modalities present useful structures for imparting professional CE. As librarians' experience with different modalities increases and as technology improves, preferences in instruction delivery may shift. But at present, face-to-face remains the most preferred modality. Based on the results of this study, cost was the most influential factor associated with attending a CE class. This may change as additional influential factors are identified and analyzed in future studies. PMID:20098656

Librarian instruction-delivery modality preferences for professional continuing education.

PubMed

Lynn, Valerie A; Bose, Arpita; Boehmer, Susan J

2010-01-01

Attending professional continuing education (CE) is an important component of librarianship. This research study identified librarians' preferences in delivery modalities of instruction for professional CE. The study also identified influential factors associated with attending CE classes. Five instruction-delivery modalities and six influential factors were identified for inclusion in an online survey. The survey completed by members of the American Library Association (ALA), Special Libraries Association (SLA), and Medical Library Association (MLA) provided the data for analysis of librarian preferences and influential factors. The majority of respondents were MLA members, followed by ALA and SLA members. Librarians from all three library associations preferred the face-to-face instructional modality. The most influential factor associated with the decision to attend a professional CE class was cost. All five instruction-delivery modalities present useful structures for imparting professional CE. As librarians' experience with different modalities increases and as technology improves, preferences in instruction delivery may shift. But at present, face-to-face remains the most preferred modality. Based on the results of this study, cost was the most influential factor associated with attending a CE class. This may change as additional influential factors are identified and analyzed in future studies.

DNA-Encoded Solid-Phase Synthesis: Encoding Language Design and Complex Oligomer Library Synthesis.

PubMed

MacConnell, Andrew B; McEnaney, Patrick J; Cavett, Valerie J; Paegel, Brian M

2015-09-14

The promise of exploiting combinatorial synthesis for small molecule discovery remains unfulfilled due primarily to the "structure elucidation problem": the back-end mass spectrometric analysis that significantly restricts one-bead-one-compound (OBOC) library complexity. The very molecular features that confer binding potency and specificity, such as stereochemistry, regiochemistry, and scaffold rigidity, are conspicuously absent from most libraries because isomerism introduces mass redundancy and diverse scaffolds yield uninterpretable MS fragmentation. Here we present DNA-encoded solid-phase synthesis (DESPS), comprising parallel compound synthesis in organic solvent and aqueous enzymatic ligation of unprotected encoding dsDNA oligonucleotides. Computational encoding language design yielded 148 thermodynamically optimized sequences with Hamming string distance ≥ 3 and total read length <100 bases for facile sequencing. Ligation is efficient (70% yield), specific, and directional over 6 encoding positions. A series of isomers served as a testbed for DESPS's utility in split-and-pool diversification. Single-bead quantitative PCR detected 9 × 10(4) molecules/bead and sequencing allowed for elucidation of each compound's synthetic history. We applied DESPS to the combinatorial synthesis of a 75,645-member OBOC library containing scaffold, stereochemical and regiochemical diversity using mixed-scale resin (160-μm quality control beads and 10-μm screening beads). Tandem DNA sequencing/MALDI-TOF MS analysis of 19 quality control beads showed excellent agreement (<1 ppt) between DNA sequence-predicted mass and the observed mass. DESPS synergistically unites the advantages of solid-phase synthesis and DNA encoding, enabling single-bead structural elucidation of complex compounds and synthesis using reactions normally considered incompatible with unprotected DNA. The widespread availability of inexpensive oligonucleotide synthesis, enzymes, DNA sequencing, and PCR make implementation of DESPS straightforward, and may prompt the chemistry community to revisit the synthesis of more complex and diverse libraries.

Suggestions for Library Network Design.

ERIC Educational Resources Information Center

Salton, Gerald

1979-01-01

Various approaches to the design of automatic library systems are described, suggestions for the design of rational and effective automated library processes are posed, and an attempt is made to assess the importance and effect of library network systems on library operations and library effectiveness. (Author/CWM)

Trends in Source of Catalog Records for European Monographs 1996-2000: A Preliminary Study of Italian Monographs.

ERIC Educational Resources Information Center

Kellsey, Charlene

2001-01-01

Discusses catalog records for non-English books created by European booksellers and loaded into OCLC; describes a study of Italian language monographs to compare vendor records with Library of Congress and OCLC member libraries' records; and considers changes in cataloging workflow needed to edit records to include Library of Congress call numbers…

Communication, Collaboration, and Enhancing the Learning Experience: Developing a Collaborative Virtual Enquiry Service in University Libraries in the North of England

ERIC Educational Resources Information Center

Jolly, Liz; White, Sue

2016-01-01

This article uses the case study of developing a collaborative "out-of-hours" virtual enquiry service by members of the Northern Collaboration Group of academic libraries in the north of England to explore the importance of communication and collaboration between academic library services in enhancing student learning. Set within the…

Automation of Technical Service Functions in Academic, Public, and Special Libraries in Tennessee: Report of a Survey.

ERIC Educational Resources Information Center

Denton, Ann; Mahood, Ramona M.

Members of the Tennessee Library Association's Technical Services Roundtable examined the extent to which the developing technology of automation is being utilized by the state's libraries. The survey encompassed technical service activities and had a two-fold thrust: to determine how automation is being employed, and to compile an inventory of…

Play with the Slinky[R]: Learning to Lead Collaboration through a Statewide Training Project Aimed at Grants for Community Partnerships

ERIC Educational Resources Information Center

Curry, Elizabeth A.

2005-01-01

How can training develop the philosophical commitment that library staff members need to successfully lead collaborative projects? How do conversation as a training model and play as an activity shape the collaborative learning process? How do we stimulate libraries and library staff to assume leadership roles in community building? This article…

Planning Library Services; Proceedings of a Research Seminar (University of Lancaster 9-11 July 1969).

ERIC Educational Resources Information Center

Mackenzie, A. Graham, Ed.; Stuart, Ian M., Ed.

This proceedings volume of a seminar on planning library services is the third in a series of papers, published at irregular intervals, to report on research work by members of the University of Lancaster library staff. From January 1967 until June 1969 the Office of Scientific and Technical Information (OSTI) organized regular meetings under the…

What Do Librarians Think about Marketing? A Survey of Public Librarians' Attitudes toward the Marketing of Library Services

ERIC Educational Resources Information Center

Shontz, Marilyn L.; Parker, Jon C.; Parker, Richard

2004-01-01

The purpose of this study was to identify attitudes of public librarians toward the marketing of library services and relate these attitudes to selected independent variables. A questionnaire was mailed to individual members of the New Jersey Library Association. Although most of the respondents had generally positive attitudes toward library…

The Medical Library Association Benchmarking Network: development and implementation.

PubMed

Dudden, Rosalind Farnam; Corcoran, Kate; Kaplan, Janice; Magouirk, Jeff; Rand, Debra C; Smith, Bernie Todd

2006-04-01

This article explores the development and implementation of the Medical Library Association (MLA) Benchmarking Network from the initial idea and test survey, to the implementation of a national survey in 2002, to the establishment of a continuing program in 2004. Started as a program for hospital libraries, it has expanded to include other nonacademic health sciences libraries. The activities and timelines of MLA's Benchmarking Network task forces and editorial board from 1998 to 2004 are described. The Benchmarking Network task forces successfully developed an extensive questionnaire with parameters of size and measures of library activity and published a report of the data collected by September 2002. The data were available to all MLA members in the form of aggregate tables. Utilization of Web-based technologies proved feasible for data intake and interactive display. A companion article analyzes and presents some of the data. MLA has continued to develop the Benchmarking Network with the completion of a second survey in 2004. The Benchmarking Network has provided many small libraries with comparative data to present to their administrators. It is a challenge for the future to convince all MLA members to participate in this valuable program.

The Medical Library Association Benchmarking Network: development and implementation*

PubMed Central

Dudden, Rosalind Farnam; Corcoran, Kate; Kaplan, Janice; Magouirk, Jeff; Rand, Debra C.; Smith, Bernie Todd

2006-01-01

Objective: This article explores the development and implementation of the Medical Library Association (MLA) Benchmarking Network from the initial idea and test survey, to the implementation of a national survey in 2002, to the establishment of a continuing program in 2004. Started as a program for hospital libraries, it has expanded to include other nonacademic health sciences libraries. Methods: The activities and timelines of MLA's Benchmarking Network task forces and editorial board from 1998 to 2004 are described. Results: The Benchmarking Network task forces successfully developed an extensive questionnaire with parameters of size and measures of library activity and published a report of the data collected by September 2002. The data were available to all MLA members in the form of aggregate tables. Utilization of Web-based technologies proved feasible for data intake and interactive display. A companion article analyzes and presents some of the data. MLA has continued to develop the Benchmarking Network with the completion of a second survey in 2004. Conclusions: The Benchmarking Network has provided many small libraries with comparative data to present to their administrators. It is a challenge for the future to convince all MLA members to participate in this valuable program. PMID:16636702

Information about Musculoskeletal Conditions

MedlinePlus

... on Advocacy NOLC AAOS Liaison Program Membership Membership Information Become a Member Member Benefits Bylaws Library Diversity ... Information Statements Ethics Resources Resolutions Patient, Public & Media Information OrthoInfo Patient Education Newsroom/Media Resources Find an ...

Protocols for the Design of Kinase-focused Compound Libraries.

PubMed

Jacoby, Edgar; Wroblowski, Berthold; Buyck, Christophe; Neefs, Jean-Marc; Meyer, Christophe; Cummings, Maxwell D; van Vlijmen, Herman

2018-05-01

Protocols for the design of kinase-focused compound libraries are presented. Kinase-focused compound libraries can be differentiated based on the design goal. Depending on whether the library should be a discovery library specific for one particular kinase, a general discovery library for multiple distinct kinase projects, or even phenotypic screening, there exists today a variety of in silico methods to design candidate compound libraries. We address the following scenarios: 1) Datamining of SAR databases and kinase focused vendor catalogues; 2) Predictions and virtual screening; 3) Structure-based design of combinatorial kinase inhibitors; 4) Design of covalent kinase inhibitors; 5) Design of macrocyclic kinase inhibitors; and 6) Design of allosteric kinase inhibitors and activators. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Consortia for Engineering, Science and Technology Libraries in India: A Case Study of INDEST Consortium

NASA Astrophysics Data System (ADS)

Pathak, S. K.; Deshpande, N. J.

2007-10-01

The present scenario of the INDEST Consortium among engineering, science and technology (including astronomy and astrophysics) libraries in India is discussed. The Indian National Digital Library in Engineering Sciences & Technology (INDEST) Consortium is a major initiative of the Ministry of Human Resource Development, Government of India. The INDEST Consortium provides access to 16 full text e-resources and 7 bibliographic databases for 166 institutions as members who are taking advantage of cost effective access to premier resources in engineering, science and technology, including astronomy and astrophysics. Member institutions can access over 6500 e-journals from 1092 publishers. Out of these, over 150 e-journals are exclusively for the astronomy and physics community. The current study also presents a comparative analysis of the key features of nine major services, viz. ACM Digital Library, ASCE Journals, ASME Journals, EBSCO Databases (Business Source Premier), Elsevier's Science Direct, Emerald Full Text, IEEE/IEE Electronic Library Online (IEL), ProQuest ABI/INFORM and Springer Verlag's Link. In this paper, the limitations of this consortium are also discussed.

Sharing Control, Embracing Collaboration: Cross-Campus Partnerships for Library Website Design and Management

ERIC Educational Resources Information Center

Stephenson, Kimberley

2012-01-01

Cross-campus collaboration for library website design and management can be challenging, but the process can produce stronger, more attractive, and more usable library websites. Collaborative library website design and management can also lead to new avenues for marketing library tools and services; expert consultation for library technology…

Jannovar: a java library for exome annotation.

PubMed

Jäger, Marten; Wang, Kai; Bauer, Sebastian; Smedley, Damian; Krawitz, Peter; Robinson, Peter N

2014-05-01

Transcript-based annotation and pedigree analysis are two basic steps in the computational analysis of whole-exome sequencing experiments in genetic diagnostics and disease-gene discovery projects. Here, we present Jannovar, a stand-alone Java application as well as a Java library designed to be used in larger software frameworks for exome and genome analysis. Jannovar uses an interval tree to identify all transcripts affected by a given variant, and provides Human Genome Variation Society-compliant annotations both for variants affecting coding sequences and splice junctions as well as untranslated regions and noncoding RNA transcripts. Jannovar can also perform family-based pedigree analysis with Variant Call Format (VCF) files with data from members of a family segregating a Mendelian disorder. Using a desktop computer, Jannovar requires a few seconds to annotate a typical VCF file with exome data. Jannovar is freely available under the BSD2 license. Source code as well as the Java application and library file can be downloaded from http://compbio.charite.de (with tutorial) and https://github.com/charite/jannovar. © 2014 WILEY PERIODICALS, INC.

St. Louis Regional Library Network Manuals: Delivery System Manual, INFO-PASS Manual, Interlibrary Loan Protocol, Procedures and Policies Manual.

ERIC Educational Resources Information Center

Saint Louis Regional Library Network, MO.

Included in this set of manuals are: (1) guidelines for document delivery to member libraries within the St. Louis Regional Library Network (SLRLN) in which eligible materials are described, addressing and packing are outlined, routing and deliveries are discussed, and a list of delivery system participants is provided; (2) a descriptive guide to…

The Library Environment, Aspects of Interior Planning. Proceedings of the Library Equipment Institute (St. Louis, Missouri, June 26-27, 1964).

ERIC Educational Resources Information Center

Poole, Frazer G., Ed.

The texts of the papers given at the Library Equipment Institute, as well as the presentations of the panelists and the discussions between members of the audience and the program speakers, are included. Diagrams and other illustrative materials accompany the text. Specific topics include--(1) furnishings, (2) illumination, (3) audio, (4)…

Planning Library Services; Proceedings of a Research Seminar Held at the University of Lancaster 9-11 July 1969.

ERIC Educational Resources Information Center

Mackenzie, A. Graham, Ed.; Stuart, Ian M., Ed.

This proceedings volume of a seminar on planning library services is the third in a series of papers, published at irregular intervals, to report on research work by members of the University of Lancaster library staff. From January 1967 until June 1969 the Office of Scientific and Technical Information (OSTI) organized regular meetings under the…

AAHSL Twitter Use From 2007 to 2014: An Exploratory Analysis.

PubMed

Stellrecht, Elizabeth; Hendrix, Dean

2016-01-01

Twitter is a popular social media platform used by organizations for communication and marketing purposes. Many libraries, including members of the Association of Academic Health Sciences Libraries (AAHSL), have Twitter accounts, but how do these libraries use Twitter to communicate with their constituents and are they using it effectively? This study is a large-scale observational study of Twitter use within AAHSL libraries and reflects on the usage patterns present in the context of social media best practices. This study also aims to expand upon best practices for implementing and maintaining a Twitter account in a health sciences library setting.

Development and Synthesis of DNA-Encoded Benzimidazole Library.

PubMed

Ding, Yun; Chai, Jing; Centrella, Paolo A; Gondo, Chenaimwoyo; DeLorey, Jennifer L; Clark, Matthew A

2018-04-25

Encoded library technology (ELT) is an effective approach to the discovery of novel small-molecule ligands for biological targets. A key factor for the success of the technology is the chemical diversity of the libraries. Here we report the development of DNA-conjugated benzimidazoles. Using 4-fluoro-3-nitrobenzoic acid as a key synthon, we synthesized a 320 million-member DNA-encoded benzimidazole library using Fmoc-protected amino acids, amines and aldehydes as diversity elements. Affinity selection of the library led to the discovery of a novel, potent and specific antagonist of the NK3 receptor.

Library of Michigan: Financial Management Reference Guide.

ERIC Educational Resources Information Center

Michigan Library, Lansing.

Developed to provide library directors, staff, and board members with information for performing accounting and financial management functions, this guide answers frequently asked questions, describes common practices and processes, provides examples and suggested formats for selected financial reports, and identifies issues that may require…

Building Context-Based Library Instruction

ERIC Educational Resources Information Center

Roldan, Malu; Wu, Yuhfen Diana

2004-01-01

Information overload and rapid technology changes are among the most significant challenges to all professions, particularly information technology workers and librarians. Little is known about the effectiveness of partnerships among librarians and faculty members that result in context-based library instruction. In this study, the authors…

Design of targeted libraries against the human Chk1 kinase using PGVL Hub.

PubMed

Peng, Zhengwei; Hu, Qiyue

2011-01-01

PGVL Hub is a Pfizer internal desktop tool for chemical library and singleton design. In this chapter, we give a short introduction to PGVL Hub, the core workflow it supports, and the rich design capabilities it provides. By re-creating two legacy targeted libraries against the human checkpoint kinase 1 (Chk1) as a showcase, we illustrate how PGVL Hub could be used to help library designers carry out the steps in library design and realize design objectives such as SAR expansion and improvement in both kinase selectivity and compound aqueous solubility. Finally we share several tips about library design and usage of PGVL Hub.

Design Principles for the Information Architecture of a SMET Education Digital Library.

ERIC Educational Resources Information Center

Dong, Andy; Agogino, Alice M.

This implementation paper introduces principles for the information architecture of an educational digital library, principles that address the distinction between designing digital libraries for education and designing digital libraries for information retrieval in general. Design is a key element of any successful product. Good designers and…

Design of compound libraries for fragment screening

NASA Astrophysics Data System (ADS)

Blomberg, Niklas; Cosgrove, David A.; Kenny, Peter W.; Kolmodin, Karin

2009-08-01

Approaches to the design of libraries for fragment screening are illustrated with reference to a 20 k generic fragment screening library and a 1.2 k generic NMR screening library. Tools and methods for library design that have been developed within AstraZeneca are described, including Foyfi fingerprints and the Flush program for neighborhood characterization. It will be shown how Flush and the BigPicker, which selects maximally diverse sets of compounds, are used to apply the Core and Layer method for library design. Approaches to partitioning libraries into cocktails are also described.

Simulated Screens of DNA Encoded Libraries: The Potential Influence of Chemical Synthesis Fidelity on Interpretation of Structure-Activity Relationships.

PubMed

Satz, Alexander L

2016-07-11

Simulated screening of DNA encoded libraries indicates that the presence of truncated byproducts complicates the relationship between library member enrichment and equilibrium association constant (these truncates result from incomplete chemical reactions during library synthesis). Further, simulations indicate that some patterns observed in reported experimental data may result from the presence of truncated byproducts in the library mixture and not structure-activity relationships. Potential experimental methods of minimizing the presence of truncates are assessed via simulation; the relationship between enrichment and equilibrium association constant for libraries of differing purities is investigated. Data aggregation techniques are demonstrated that allow for more accurate analysis of screening results, in particular when the screened library contains significant quantities of truncates.

Standards for hospital libraries 2002

PubMed Central

Gluck, Jeannine Cyr; Hassig, Robin Ackley; Balogh, Leeni; Bandy, Margaret; Doyle, Jacqueline Donaldson; Kronenfeld, Michael R.; Lindner, Katherine Lois; Murray, Kathleen; Petersen, JoAn; Rand, Debra C.

2002-01-01

The Medical Library Association's “Standards for Hospital Libraries 2002” have been developed as a guide for hospital administrators, librarians, and accrediting bodies to ensure that hospitals have the resources and services to effectively meet their needs for knowledge-based information. Specific requirements for knowledge-based information include that the library be a separate department with its own budget. Knowledge-based information in the library should be directed by a qualified librarian who functions as a department head and is a member of the Academy of Health Information Professionals. The standards define the role of the medical librarian and the links between knowledge-based information and other functions such as patient care, patient education, performance improvement, and education. In addition, the standards address the development and implementation of the knowledge-based information needs assessment and plans, the promotion and publicity of the knowledge-based information services, and the physical space and staffing requirements. The role, qualifications, and functions of a hospital library consultant are outlined. The health sciences library is positioned to play a key role in the hospital. The increasing use of the Internet and new information technologies by medical, nursing, and allied health staffs; patients; and the community require new strategies, strategic planning, allocation of adequate resources, and selection and evaluation of appropriate information resources and technologies. The Hospital Library Standards Committee has developed this document as a guideline to be used in facing these challenges. Editor's Note: The “Standards for Hospital Libraries 2002” were approved by the members of the Hospital Library Section during MLA '02 in Dallas, Texas. They were subsequently approved by Section Council and received final approval from the MLA Board of Directors in June 2002. They succeed the Standards for Hospital Libraries published in 1994 and the Minimum Standards for Health Sciences Libraries in Hospitals from 1983. A Frequently Asked Questions document discussing the development of the new standards can be found on the Hospital Library Section Website at http://www.hls.mlanet.org. PMID:12398254

Personnel Needs of Two-Year College Libraries.

ERIC Educational Resources Information Center

Blocker, Clyde E.

Community college librarians should have an understanding of student and faculty characteristics at the local institution, occupationally oriented programs, and the role of professional and semiprofessional library staff members in order to serve their clientele more adequately. Realizing that community college students have average or below…

Faculty Handbook and Library Guide.

ERIC Educational Resources Information Center

City Univ. of New York, Bronx, NY. Herbert H. Lehman Coll.

This 1975 handbook covers both faculty policies and library services at the college. Administrative officers and their responsibilities are described in a brief section on administrative organization. Details pertinent to faculty members include those on faculty rank and status, titles, duties, committees, faculty Senate, department organization,…

For Distinguished Public Service: Medical Library Association Honors FNLM and NIH MedlinePlus Magazine | NIH ...

MedlinePlus

... warm and mutually appreciative relationship with the Medical Library Association (MLA) and its more than 3,600 individual members, representing more than 1,100 institutions in the health sciences information field. They do wonderful work educating health ...

Online Reference Service--How to Begin: A Selected Bibliography.

ERIC Educational Resources Information Center

Shroder, Emelie J., Ed.

1982-01-01

Materials in this bibliography were selected and recommended by members of the Use of Machine-Assisted Reference in Public Libraries Committee, Reference and Adult Services Division, American Library Association. Topics include: financial aspects, equipment and communications considerations, comparing databases and database systems, advertising…

Libraries of 2β-(N-substituted piperazino)-5α-androstane-3α, 17β-diols: chemical synthesis and cytotoxic effects on human leukemia HL-60 cells and on normal lymphocytes.

PubMed

Roy, Jenny; Maltais, René; Jegham, Hajer; Poirier, Donald

2011-05-01

Libraries of steroid derivatives with two levels of molecular diversity were prepared to optimize the antiproliferative activity on leukemia HL-60 cells by first varying the amino acid (AA) at R(1) (libraries A, B, C, and D: with 45, 45, 20, and 20 members, respectively) and, subsequently, the capping group at R(2) (library E: 168 members). The screening of these aminosteroids revealed interesting structure-activity relationships. In library A, the compounds bearing a tetrahydroisoquinolone residue as the first element of diversity showed potent cytotoxicity, principally when isovaleric or cyclohexyl acetic acid was used as a capping group (>40% of cell growth inhibition at 1 μM). In library B, the phenylalanine (Phe) derivatives bearing a cyano group induced a higher growth inhibition than the other Phe derivatives. The screening of library C indicated the increase of hydrophobicity of proline (Pro) seems to preserve the cytotoxic effect achieved by the lead compound. However, the synthesis of structural Pro variants (library D) clearly shows weaker activities when compared to L-Pro building blocks. Finally, by incorporating some of the most active AA of libraries A-D in library E, we observed that the amide coupling functionality gave stronger cytotoxic activity compared to the corresponding sulfonamides or benzylamines. Six of the most active amide derivatives (E-37P, E-41P, E-42P, E-46P, E-48F, and E-12T) were selected and IC(50) determined on HL-60 cells as well as on normal human lymphocytes. Among this series of new anticancer agents, good to high selectivity indices (SI = IC(50) (lymphocytes)/IC(50) (HL-60 cells) = 5 - 55) were obtained.

Changing Dimensions: Managing Library and Information Services for the 1990s: A Global Perspective. Proceedings of the Asian/Pacific American Librarians Association [Conference] (Atlanta, Georgia, July 1, 1991).

ERIC Educational Resources Information Center

Sharma, Ravindra Nath, Ed.

The theme of the 1991 Asian/Pacific American Librarians Association (APALA) was "Changing Dimensions: Managing Library Information Services for the 1990s and Beyond." Members and speakers were invited to discuss this topic from all dimensions of library and information related fields. Presenters had the options either to write on actual…

The impact of institutional ethics on academic health sciences library leadership: a survey of academic health sciences library directors.

PubMed

Tooey, Mary Joan M J; Arnold, Gretchen N

2014-10-01

Ethical behavior in libraries goes beyond service to users. Academic health sciences library directors may need to adhere to the ethical guidelines and rules of their institutions. Does the unique environment of an academic health center imply different ethical considerations? Do the ethical policies of institutions affect these library leaders? Do their personal ethical considerations have an impact as well? In December 2013, a survey regarding the impact of institutional ethics was sent to the director members of the Association of Academic Health Sciences Libraries. The objective was to determine the impact of institutional ethics on these leaders, whether through personal conviction or institutional imperative.

The impact of institutional ethics on academic health sciences library leadership: a survey of academic health sciences library directors

PubMed Central

Tooey, Mary Joan (M.J.); Arnold, Gretchen N.

2014-01-01

Ethical behavior in libraries goes beyond service to users. Academic health sciences library directors may need to adhere to the ethical guidelines and rules of their institutions. Does the unique environment of an academic health center imply different ethical considerations? Do the ethical policies of institutions affect these library leaders? Do their personal ethical considerations have an impact as well? In December 2013, a survey regarding the impact of institutional ethics was sent to the director members of the Association of Academic Health Sciences Libraries. The objective was to determine the impact of institutional ethics on these leaders, whether through personal conviction or institutional imperative. PMID:25349542

A High-Throughput TNP-ATP Displacement Assay for Screening Inhibitors of ATP-Binding in Bacterial Histidine Kinases

PubMed Central

Guarnieri, Michael T.; Blagg, Brian S. J.

2011-01-01

Abstract Bacterial histidine kinases (HK) are members of the GHKL superfamily, which share a unique adenosine triphosphate (ATP)-binding Bergerat fold. Our previous studies have shown that Gyrase, Hsp90, MutL (GHL) inhibitors bind to the ATP-binding pocket of HK and may provide lead compounds for the design of novel antibiotics targeting these kinases. In this article, we developed a competition assay using the fluorescent ATP analog, 2′,3′-O-(2,4,6-trinitrophenyl) adenosine 5′-triphosphate. The method can be used for high-throughput screening of compound libraries targeting HKs or other ATP-binding proteins. We utilized the assay to screen a library of GHL inhibitors targeting the bacterial HK PhoQ, and discuss the applications of the 2′,3′-O-(2,4,6-trinitrophenyl) adenosine 5′-triphosphate competition assay beyond GHKL inhibitor screening. PMID:21050069

Design of a Selective Substrate and Activity Based Probe for Human Neutrophil Serine Protease 4

PubMed Central

Kasperkiewicz, Paulina; Poreba, Marcin; Snipas, Scott J.; Lin, S. Jack; Kirchhofer, Daniel; Salvesen, Guy S.; Drag, Marcin

2015-01-01

Human neutrophil serine protease 4 (NSP4), also known as PRSS57, is a recently discovered fourth member of the neutrophil serine proteases family. Although its biological function is not precisely defined, it is suggested to regulate neutrophil response and innate immune reactions. To create optimal substrates and visualization probes for NSP4 that distinguish it from other NSPs we have employed a Hybrid Combinatorial Substrate Library approach that utilizes natural and unnatural amino acids to explore protease subsite preferences. Library results were validated by synthesizing individual substrates, leading to the identification of an optimal substrate peptide. This substrate was converted to a covalent diphenyl phosphonate probe with an embedded biotin tag. This probe demonstrated high inhibitory activity and stringent specificity and may be suitable for visualizing NSP4 in the background of other NSPs. PMID:26172376

Characteristics of a semi-custom library development system

NASA Technical Reports Server (NTRS)

Yancey, M.; Cannon, R.

1990-01-01

Standard cell and gate array macro libraries are in common use with workstation computer aided design (CAD) tools for application specific integrated circuit (ASIC) semi-custom application and have resulted in significant improvements in the overall design efficiencies as contrasted with custom design methodologies. Similar design methodology enhancements in providing for the efficient development of the library cells is an important factor in responding to the need for continuous technology improvement. The characteristics of a library development system that provides design flexibility and productivity enhancements for the library development engineer as he provides libraries in the state-of-the-art process technologies are presented. An overview of Gould's library development system ('Accolade') is also presented.

Technical Services Workstations. SPEC Kit 213.

ERIC Educational Resources Information Center

Brugger, Judith M., Comp.; And Others

Technical services workstations (TSWs) are personal computers that have been customized for use in technical services departments. To gather information on their use and prevalence in research libraries, the Program for Cooperative Cataloging Standing Committee on Automation surveyed the 119 members of the Association of Research Libraries (ARL)…

Ohio College Library Center Annual Report 1974/1975.

ERIC Educational Resources Information Center

OCLC Online Computer Library Center, Inc., Dublin, OH.

The 1974-75 annual report of the Ohio College Library Center (OCLC) provides statistics, tables, and narrative information about OCLC's operation, particularly its on-line cataloging services. A detailed financial statement is included. Members as of June 1975 are listed, as are the OCLC trustees. (LS)

The Imperative for Diversity: ARL's Progress and Role

ERIC Educational Resources Information Center

Dewey, Barbara I.

2009-01-01

The Association of Research Libraries' diversity initiatives, under the leadership of Duane Webster and member libraries, have had a visible and long-lasting influence on the makeup of academic librarianship. ARL's accomplishments and progress in advancing diversity comprise important milestones for librarianship and did not come without…

Assess and Invest: Faculty Feedback on Library Tutorials

ERIC Educational Resources Information Center

Appelt, Kristina M.; Pendell, Kimberly

2010-01-01

Communication and collaboration with faculty are increasingly important in the development of both curriculum-integrated and stand-alone "just in time" library tutorials. In the final developmental stages of the Evidence-Based Practice online tutorials, faculty members were asked to provide input during structured faculty feedback…

Montana Certification Program Manual.

ERIC Educational Resources Information Center

Montana State Library, Helena.

The Montana Certification Program offers librarians, library staff members, and trustees a systematic and progressive method by which to track their continuing education (CE) efforts; the program also offers library boards and managers an opportunity to recognize staff efforts to improve their skills, ability, and knowledge. This first section of…

Promoting Learning in Libraries through Information Literacy.

ERIC Educational Resources Information Center

Breivik, Patricia Senn; Ford, Barbara J.

1993-01-01

Discusses information literacy and describes activities under the sponsorship of the National Forum on Information Literacy (NFIL) that promotes information literacy in schools and libraries. Activities of member organizations of the NFIL are described, including policy formation, publications, and programs; and the role of the American Library…

The Data Conservancy

NASA Astrophysics Data System (ADS)

Choudhury, S.; Duerr, R. E.

2009-12-01

NSF's Sustainable Digital Data Preservation and Access Network Partners program is an ambitious attempt to integrate a wide variety of expertise and infrastructure into a network for providing "reliable digital preservation, access, integration, and analysis capabilities for science." One of the first two DataNet award recipients, the Data Conservancy, is itself a network of widely diverse partners led by the libraries at the Johns Hopkins University. The Data Conservancy is built on existing exemplar scientific projects, communities, and virtual organizations that have deep engagement with their user communities, and extensive experience with large-scale distributed system development. Data Conservancy members embrace a shared vision that data curation is not an end, but rather a means to collect, organize, validate, and preserve data needed to address the grand research challenges that face society. Data Conservancy members holdings encompass the entire range of earth, life, and space science data. New to the Data Conservancy is the concept that University libraries will be part of the distributed network of data centers and that data science will become a path in the library and information science curricula. As noted by Winston Tabb (JHU Dean of Libraries) "Data Centers are the new library stacks."

Library Buildings Section. Papers.

ERIC Educational Resources Information Center

International Federation of Library Associations, The Hague (Netherlands).

Papers on library architecture, which were presented at the 1982 International Federation of Library Associations (IFLA) conference focus on the effect of library networks on library design. Topics include: (1) "Some Problems in Designing of the University Library Buildings in China: A Developing Country University Librarian's View Based on…

SNAr-Based, facile synthesis of a library of Benzothiaoxazepine-1,1’-dioxides

PubMed Central

Rolfe, Alan; Samarakoon, Thiwanka B.; Klimberg, Sarra V.; Brzozowski, Marek; Neuenswander, Benjamin; Lushington, Gerald H.

2011-01-01

The construction of a library of benzothiaoxazepine-1,1’-dioxides utilizing a one-pot, SNAr diversification – ODCT50 scavenging protocol is reported. This protocol combines microwave irradiation to facilitate the reaction, in conjunction with a soluble ROMP-derived scavenger (ODCT) to afford the desired products in good overall purity. Utilizing this protocol, a 78-member library was successfully synthesized and submitted for biological evaluation. PMID:20879738

Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries

PubMed Central

Harris, Jennifer L.; Backes, Bradley J.; Leonetti, Francesco; Mahrus, Sami; Ellman, Jonathan A.; Craik, Charles S.

2000-01-01

A method is presented for the preparation and use of fluorogenic peptide substrates that allows for the configuration of general substrate libraries to rapidly identify the primary and extended specificity of proteases. The substrates contain the fluorogenic leaving group 7-amino-4-carbamoylmethylcoumarin (ACC). Substrates incorporating the ACC leaving group show kinetic profiles comparable to those with the traditionally used 7-amino-4-methylcoumarin (AMC) leaving group. The bifunctional nature of ACC allows for the efficient production of single substrates and substrate libraries by using 9-fluorenylmethoxycarbonyl (Fmoc)-based solid-phase synthesis techniques. The approximately 3-fold-increased quantum yield of ACC over AMC permits reduction in enzyme and substrate concentrations. As a consequence, a greater number of substrates can be tolerated in a single assay, thus enabling an increase in the diversity space of the library. Soluble positional protease substrate libraries of 137,180 and 6,859 members, possessing amino acid diversity at the P4-P3-P2-P1 and P4-P3-P2 positions, respectively, were constructed. Employing this screening method, we profiled the substrate specificities of a diverse array of proteases, including the serine proteases thrombin, plasmin, factor Xa, urokinase-type plasminogen activator, tissue plasminogen activator, granzyme B, trypsin, chymotrypsin, human neutrophil elastase, and the cysteine proteases papain and cruzain. The resulting profiles create a pharmacophoric portrayal of the proteases to aid in the design of selective substrates and potent inhibitors. PMID:10869434

Adiabatic quantum-flux-parametron cell library adopting minimalist design

DOE Office of Scientific and Technical Information (OSTI.GOV)

Takeuchi, Naoki, E-mail: takeuchi-naoki-kx@ynu.jp; Yamanashi, Yuki; Yoshikawa, Nobuyuki

We herein build an adiabatic quantum-flux-parametron (AQFP) cell library adopting minimalist design and a symmetric layout. In the proposed minimalist design, every logic cell is designed by arraying four types of building block cells: buffer, NOT, constant, and branch cells. Therefore, minimalist design enables us to effectively build and customize an AQFP cell library. The symmetric layout reduces unwanted parasitic magnetic coupling and ensures a large mutual inductance in an output transformer, which enables very long wiring between logic cells. We design and fabricate several logic circuits using the minimal AQFP cell library so as to test logic cells inmore » the library. Moreover, we experimentally investigate the maximum wiring length between logic cells. Finally, we present an experimental demonstration of an 8-bit carry look-ahead adder designed using the minimal AQFP cell library and demonstrate that the proposed cell library is sufficiently robust to realize large-scale digital circuits.« less

Adiabatic quantum-flux-parametron cell library adopting minimalist design

NASA Astrophysics Data System (ADS)

Takeuchi, Naoki; Yamanashi, Yuki; Yoshikawa, Nobuyuki

2015-05-01

We herein build an adiabatic quantum-flux-parametron (AQFP) cell library adopting minimalist design and a symmetric layout. In the proposed minimalist design, every logic cell is designed by arraying four types of building block cells: buffer, NOT, constant, and branch cells. Therefore, minimalist design enables us to effectively build and customize an AQFP cell library. The symmetric layout reduces unwanted parasitic magnetic coupling and ensures a large mutual inductance in an output transformer, which enables very long wiring between logic cells. We design and fabricate several logic circuits using the minimal AQFP cell library so as to test logic cells in the library. Moreover, we experimentally investigate the maximum wiring length between logic cells. Finally, we present an experimental demonstration of an 8-bit carry look-ahead adder designed using the minimal AQFP cell library and demonstrate that the proposed cell library is sufficiently robust to realize large-scale digital circuits.

How a Library Can Develop the Ability in Disability

ERIC Educational Resources Information Center

Jaworski, Susan

2009-01-01

Staff members at E. H. Butler Library, Buffalo State College, have collaborated with the College-Based Transition Program to help students with disabilities achieve a more rounded, fulfilling college experience. The CBTP program is a partnership between the Buffalo Public Schools, People Inc., Parents for Public Schools, and Buffalo State…

Flexible Work Arrangements in ARL Libraries. SPEC Kit #180.

ERIC Educational Resources Information Center

Zabel, Diane, Comp.; And Others

This report presents the results of a survey of Association of Research Libraries (ARL) members about the current climate and practices regarding flexible work arrangements. Data are reported on the availability of schedule flexibility, job exchange, part-time arrangements, and leaves, as well as information about faculty status, tenure,…

Creating a Professional Library

ERIC Educational Resources Information Center

Russel, Priscilla

2008-01-01

Compiling a personal professional library should be a priority for each teacher. The author canvassed the Executive Board of the National Network for Early Language Learning (NNELL) to elicit its members' "must haves" among foreign language texts. In this article, the author presents a list of publications which form a foundation of resources…

Bunko: Private Mini-Libraries for Children in Japan.

ERIC Educational Resources Information Center

Takeuchi, Satoru

"Bunko" are local mini-libraries for children in Japan, operated voluntarily by individuals or groups of parents, intended to nurture children's reading interest by offering them an inviting reading environment. In 1993, there were an estimated 4,000 bunko in Japan, with approximately 32,000 adult bunko members (90% female). Bunko…

Library Kiosks: A Balancing Act

ERIC Educational Resources Information Center

Aegard, Joanna

2010-01-01

In 2009, the author spearheaded the Thunder Bay Public Library's (TBPL) service audit on kiosks. A task force comprising staff from the children's, reference, and adult services departments was formed to work on the audit. Task force members worked together and studied how patrons and staff use kiosks, conducted a literature review, surveyed other…

Linking Automated Systems in North Bay Libraries.

ERIC Educational Resources Information Center

Bruman, Janet

This report addresses alternative means of interconnecting or providing access to the various automated systems within the 17-member North Bay Cooperative Library System (NBC), with emphasis on providing information on the availability of materials for loan, the principal objective of the NBC Telecommunications Project, Year Two. Advantages and…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Connolly, Laura H.; Hayes, Beverly T.; Lembo, Mary Frances

NEWSBridge is a free news service produced by the Technical Library at the Pacific Northwest National Laboratory (PNNL). Developed by library staff members in late 2004 to early 2005, it is loosely based on the Oak Ridge National Laboratory’s ORNL in the News. NEWSBridge delivers headlines each weekday to a subscriber’s desktop, laptop, or mobile device.

Changing Workloads and Productivity in Interlibrary Loan.

ERIC Educational Resources Information Center

Paine, Nancy E.; Ward, John

1996-01-01

Compares interlibrary loan data from a 1995 survey of Greater Midwest Research Library Consortium and Association of Research Libraries members with a 1989 survey. Shows an increase in transaction to staff ratio and a negative correlation between transaction to staff ratio and lending fill rate. Relates factors affecting productivity, such as…

Building Security and Personal Safety. SPEC Kit 150.

ERIC Educational Resources Information Center

Bingham, Karen Havill

This report on a survey of Association of Research Libraries (ARL) member libraries on building security and personal safety policies examines three areas in detail: (1) general building security (access to the building, key distribution, patrols or monitors, intrusion prevention, lighting, work environment after dark); (2) problem behavior…

Preparing to Teach in Cyberspace: User Education in Real and Virtual Libraries.

ERIC Educational Resources Information Center

Byron, Suzanne

1995-01-01

Discussion of librarians' training for teaching user education focuses on experiments at the University of North Texas in providing resources and empowering education for librarians and staff members who teach. The use of computer-based education principles and Ranganathan's laws of library science are explained. (Author/LRW)

History of the Medical Library Association's credentialing program.

PubMed Central

Bell, J A

1996-01-01

Since the Medical Library Association (MLA) adopted the Code for the Training and Certification of Medical Librarians in 1949, MLA members have reviewed and revised the program regularly. This paper traces the history of MLA's professional recognition program to illustrate how the program has changed over time and to identify the issues that have surrounded it. These issues include the value of the program to individual members, cost to MLA, appropriate entry requirements, certification examinations, and recertification requirements. The development and operation of MLA's current credentialing program, the Academy of Health Information Professionals, is described in detail. PMID:8883980

Libraries as 'everyday' settings: the Glasgow MCISS project.

PubMed

Whitelaw, Sandy; Coburn, Jonathan; Lacey, Marion; McKee, Martin J; Hill, Carol

2017-10-01

A settings-based approach is now well-established in health promotion, initially undertaken in conventional places like schools and workplaces, but more recently being expressed in a wider range of what Torp et al. call 'everyday' settings. In this context, libraries have emerged as another potential setting whose ubiquity and accessibility suggests that they may be particularly effective in addressing health inequalities. Drawing on a case study-the Glasgow Macmillan Cancer Information and Support Services Library project-this paper reports on the potential for seeing 'libraries as settings' and in the context of a set of associated theoretical resources, specifically scrutinizes the nature of initiative implementation. Data were drawn from multiple sources: semi-structured interviews and focus groups with strategic partners and stakeholders, operational staff, project volunteers, service users and members of the general public. Qualitative data were complemented by quantitative insights from surveys with members of the partnership, libraries staff and volunteers. Despite some concerns associated with potentially hostile cultural and financial contexts that might threaten longer term sustainability, insights suggested that in pragmatic terms, the project was attracting sizable 'footfall' and successfully addressing a range of needs. Additionally, the formal implementation processes associated with project implementation were considered to have been highly successful in embedding the model into the library culture. In summary, there is evidence that libraries have the potential to be considered as supportive settings and could act as a model for an emergent vision of what libraries do. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Reinventing a health sciences digital library--organizational impact.

PubMed

Moore, Margaret E; Garrison, Scott; Hayes, Barrie; McLendon, Wallace

2003-01-01

What is the organizational impact of becoming a digital library, as well as a physical entity with facilities and collections? Is the digital library an add-on or an integrated component of the overall library package? Librarians see sweeping environmental and technological changes. The staff members feel exhilarated and challenged by the pressures to adapt quickly and effectively. Librarians recognize that a Web presence, like other technology components, must be continuously enhanced and regularly re-engineered. The Health Sciences Library, University of North Carolina at Chapel Hill, is reinventing its digital presence to better meet the needs of the community. This paper provides a case study focusing on major changes in planning processes, organizational structure, staffing, budgeting, training, communications, and operations at the Health Sciences Library.

Embedded Librarian as Research Team Member.

PubMed

Brahmi, Frances A; Kaplan, F Thomas D

2017-03-01

Adding a librarian to an upper extremity surgical and therapy practice has many advantages (educational, research, remaining on the cutting edge of technology). As an embedded team member, the librarian at the Indiana Hand to Shoulder Center prepares literature reviews, creates Google Scholar Alerts for individual clinicians, and introduces developing technologies such as 3-dimensional printers, Smartphone Apps, and online access to nontraditional resources. With the librarian relieving clinicians of these responsibilities, surgeons can devote more time to clinical and research activities. Private practices unable to support their own librarian could share access to a librarian via Skype, Face Time, and video conferencing. Another small practice alternative is contracting services from a local medical school library that designates a librarian as its liaison. Copyright © 2017 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.

Interior Design Trends in Libraries.

ERIC Educational Resources Information Center

Sager, Don, Ed.

2000-01-01

Four contributing authors discuss perspectives on current trends in library interior design. Articles include: "Trends in Library Furnishings: A Manufacturer's Perspective" (Andrea Johnson); "Libraries, Architecture, and Light: The Architect's Perspective" (Rick McCarthy); "The Library Administrator's Perspective" (Chadwick Raymond); and "The…

The World Bank Photo Library. A Report on Classification, Indexing, and Retrieval of Slide Collection; Organization and Circulation of Visual Materials and Matters Relating to Photo Library Administration.

ERIC Educational Resources Information Center

Bikshapathi, Adepu

The World Bank, a specialized agency of the United Nations, is devoted to promoting the economic development of its member nations. Its photo library, with a collection of nearly 25,000 black-and-white photographs and color slides, serves as a resource center for various activities of the Bank and other organizations. Intended as a background…

CRISPR library designer (CLD): software for multispecies design of single guide RNA libraries.

PubMed

Heigwer, Florian; Zhan, Tianzuo; Breinig, Marco; Winter, Jan; Brügemann, Dirk; Leible, Svenja; Boutros, Michael

2016-03-24

Genetic screens using CRISPR/Cas9 are a powerful method for the functional analysis of genomes. Here we describe CRISPR library designer (CLD), an integrated bioinformatics application for the design of custom single guide RNA (sgRNA) libraries for all organisms with annotated genomes. CLD is suitable for the design of libraries using modified CRISPR enzymes and targeting non-coding regions. To demonstrate its utility, we perform a pooled screen for modulators of the TNF-related apoptosis inducing ligand (TRAIL) pathway using a custom library of 12,471 sgRNAs. CLD predicts a high fraction of functional sgRNAs and is publicly available at https://github.com/boutroslab/cld.

Enriching peptide libraries for binding affinity and specificity through computationally directed library design

PubMed Central

Foight, Glenna Wink; Chen, T. Scott; Richman, Daniel; Keating, Amy E.

2017-01-01

Peptide reagents with high affinity or specificity for their target protein interaction partner are of utility for many important applications. Optimization of peptide binding by screening large libraries is a proven and powerful approach. Libraries designed to be enriched in peptide sequences that are predicted to have desired affinity or specificity characteristics are more likely to yield success than random mutagenesis. We present a library optimization method in which the choice of amino acids to encode at each peptide position can be guided by available experimental data or structure-based predictions. We discuss how to use analysis of predicted library performance to inform rounds of library design. Finally, we include protocols for more complex library design procedures that consider the chemical diversity of the amino acids at each peptide position and optimize a library score based on a user-specified input model. PMID:28236241

Enriching Peptide Libraries for Binding Affinity and Specificity Through Computationally Directed Library Design.

PubMed

Foight, Glenna Wink; Chen, T Scott; Richman, Daniel; Keating, Amy E

2017-01-01

Peptide reagents with high affinity or specificity for their target protein interaction partner are of utility for many important applications. Optimization of peptide binding by screening large libraries is a proven and powerful approach. Libraries designed to be enriched in peptide sequences that are predicted to have desired affinity or specificity characteristics are more likely to yield success than random mutagenesis. We present a library optimization method in which the choice of amino acids to encode at each peptide position can be guided by available experimental data or structure-based predictions. We discuss how to use analysis of predicted library performance to inform rounds of library design. Finally, we include protocols for more complex library design procedures that consider the chemical diversity of the amino acids at each peptide position and optimize a library score based on a user-specified input model.

Sub-threshold standard cell library design for ultra-low power biomedical applications.

PubMed

Li, Ming-Zhong; Ieong, Chio-In; Law, Man-Kay; Mak, Pui-In; Vai, Mang-I; Martins, Rui P

2013-01-01

Portable/Implantable biomedical applications usually exhibit stringent power budgets for prolonging battery life time, but loose operating frequency requirements due to small bio-signal bandwidths, typically below a few kHz. The use of sub-threshold digital circuits is ideal in such scenario to achieve optimized power/speed tradeoffs. This paper discusses the design of a sub-threshold standard cell library using a standard 0.18-µm CMOS technology. A complete library of 56 standard cells is designed and the methodology is ensured through schematic design, transistor width scaling and layout design, as well as timing, power and functionality characterization. Performance comparison between our sub-threshold standard cell library and a commercial standard cell library using a 5-stage ring oscillator and an ECG designated FIR filter is performed. Simulation results show that our library achieves a total power saving of 95.62% and a leakage power reduction of 97.54% when compared with the same design implemented by the commercial standard cell library (SCL).

36 CFR 1281.4 - What are the architectural and design standards for Presidential libraries?

Code of Federal Regulations, 2012 CFR

2012-07-01

... and design standards for Presidential libraries? 1281.4 Section 1281.4 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION NARA FACILITIES PRESIDENTIAL LIBRARY FACILITIES § 1281.4 What are the architectural and design standards for Presidential libraries? The Archivist is...

36 CFR 1281.4 - What are the architectural and design standards for Presidential libraries?

Code of Federal Regulations, 2014 CFR

2014-07-01

... and design standards for Presidential libraries? 1281.4 Section 1281.4 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION NARA FACILITIES PRESIDENTIAL LIBRARY FACILITIES § 1281.4 What are the architectural and design standards for Presidential libraries? The Archivist is...

36 CFR 1281.4 - What are the architectural and design standards for Presidential libraries?

Code of Federal Regulations, 2011 CFR

2011-07-01

... and design standards for Presidential libraries? 1281.4 Section 1281.4 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION NARA FACILITIES PRESIDENTIAL LIBRARY FACILITIES § 1281.4 What are the architectural and design standards for Presidential libraries? The Archivist is...

36 CFR 1281.4 - What are the architectural and design standards for Presidential libraries?

Code of Federal Regulations, 2010 CFR

2010-07-01

... and design standards for Presidential libraries? 1281.4 Section 1281.4 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION NARA FACILITIES PRESIDENTIAL LIBRARY FACILITIES § 1281.4 What are the architectural and design standards for Presidential libraries? The Archivist is...

The Digital Marketplace and Library and Information Education in the GCC Member Nations: A Critical Review.

ERIC Educational Resources Information Center

Rehman, Sajjad ur; Al-Ansari, Husain

2003-01-01

Assessed six library and information education programs in preparing manpower for the digital environment in three countries in the Gulf Cooperation Council (GCC): Saudi Arabia, Kuwait, and Oman. Highlights include curriculum changes; student-teacher ratio; technological, physical and instructional resources; hardware; software; vendors;…

Amelia Bedelia in the Library or Effective Communication for Leadership.

ERIC Educational Resources Information Center

Weinstein, Frances Ruth

This paper discusses ways in which how both formal and informal library leaders can utilize communication principles to persuade, motivate, and build positive employee relations. Noting that effective communication takes time, it is suggested that administrators talk with, not to, individual staff members, and that they (1) use direct eye contact;…

The Automation Inventory of Research Libraries, 1986.

ERIC Educational Resources Information Center

Sitts, Maxine K., Ed.

Based on information and data from 113 Association of Research Libraries (ARL) members that were gathered and updated between March and August 1986, this publication was generated from a database developed by ARL to provide timely, comparable information about the extent and nature of automation within the ARL community. Trends in automation are…

Causality: School Libraries and Student Success (CLASS). White Paper

ERIC Educational Resources Information Center

American Association of School Librarians, 2014

2014-01-01

On April 11 and 12, 2014, the American Association of School Librarians (AASL) held "Causality: School Libraries and Student Success" (CLASS), an IMLS-funded national forum. Dr. Thomas Cook, one of the most influential methodologists in education research, and a five member panel of expert scholars and practitioners led 50 established…

Manual for Florida Public Library Boards.

ERIC Educational Resources Information Center

Davis, Katherine E., Ed.

Intended as both a resource tool for assisting Florida public library boards in their functions and a training tool for new and inexperienced board members, this manual provides a means for compiling all information pertinent to board operations into one sourcebook and for keeping this material up-to-date. It is organized into eight chapters: (1)…

IT Legislative and Regulatory Issues Agenda. Higher Education Information Technology Alliance

ERIC Educational Resources Information Center

National Association of State Universities and Land-Grant Colleges, 2004

2004-01-01

This document represents the higher education and library community's guiding public policy agenda on information technology (IT) for the current year. The Higher Education Information Technology (HEIT) Alliance is a coalition of 11 national higher education and library associations, whose members represent a broad array of stakeholders on college…

Motivating Millennials: Improving Practices in Recruiting, Retaining, and Motivating Younger Library Staff

ERIC Educational Resources Information Center

Smith, Sara D.; Galbraith, Quinn

2012-01-01

Working with younger staff and student employees can be a challenge for library supervisors in a multigenerational workplace. Because members of the Millennial Generation have different work expectations, managers need to adjust to best meet their needs. By surveying its five hundred student employees, Brigham Young University's Harold B. Lee…

Web Site Evaluation: How Would Your School's Web Site Measure Up?

ERIC Educational Resources Information Center

Riccardi, Megan; Easton, D'Anne; Small, Ruth

2004-01-01

One of the many responsibilities teacher-librarians have recently assumed is the development of their school library's web site. Such site provide an organic "window" to the library's programs, services and resources that can be accessed by students, teachers, administrators, parents and community members. As such, they represent another vital…

A Brief Look at Introductory Information Science in Library Schools, 1980.

ERIC Educational Resources Information Center

Davis, Charles H.; Shaw, Debora

1981-01-01

Reports the extent and content of introductory information science instruction at 79 of the 105 member schools of the Association of American Library Schools (AALS). Of the 58 schools offering computer programming instruction, 38 teach BASIC; 18, PL/I-PL/C; 15, COBOL; and 12, FORTRAN. Twelve references are listed. (RAA)

CSLA's Information Literacy Summits at CUE Conferences

ERIC Educational Resources Information Center

Lofton, Jane

2018-01-01

Cultivating partnerships is a crucial advocacy strategy for school library associations building support for the work they do. School librarians cannot do their work in isolation, so it makes sense for their associations to reach out to other associations whose members work with or could potentially support school libraries and school library…

Using Wireless Devices to Enhance Reference and Information Services

ERIC Educational Resources Information Center

Forsyth, Ellen

2006-01-01

A growing number of libraries have installed wireless data connections as a way of providing access to the Internet for members of the public. Some libraries have used their wireless networks to enable staff to use wireless devices to increase their mobility, effectiveness and responsiveness to client need particularly in providing reference and…

Branch Campus Librarianship with Minimal Infrastructure: Rewards and Challenges

ERIC Educational Resources Information Center

Knickman, Elena; Walton, Kerry

2014-01-01

Delaware County Community College provides library services to its branch campus community members by stationing a librarian at a campus 5 to 20 hours each week, without any more library infrastructure than an Internet-enabled computer on the school network. Faculty and students have reacted favorably to the increased presence of librarians.…

Job Satisfaction in a South African Academic Library in Transition

ERIC Educational Resources Information Center

Hart, Genevieve

2010-01-01

Job satisfaction was investigated at a South African university library undergoing change on many fronts. The study included 31 members of staff and the data were gathered via interviews/questionnaires, informed by standard HRM job satisfaction theory. The study found a "love-hate" relationship between respondents and their work. The key…

Specific GFP-binding artificial proteins (αRep): a new tool for in vitro to live cell applications

PubMed Central

Chevrel, Anne; Urvoas, Agathe; de la Sierra-Gallay, Ines Li; Aumont-Nicaise, Magali; Moutel, Sandrine; Desmadril, Michel; Perez, Franck; Gautreau, Alexis; van Tilbeurgh, Herman; Minard, Philippe; Valerio-Lepiniec, Marie

2015-01-01

A family of artificial proteins, named αRep, based on a natural family of helical repeat was previously designed. αRep members are efficiently expressed, folded and extremely stable proteins. A large αRep library was constructed creating proteins with a randomized interaction surface. In the present study, we show that the αRep library is an efficient source of tailor-made specific proteins with direct applications in biochemistry and cell biology. From this library, we selected by phage display αRep binders with nanomolar dissociation constants against the GFP. The structures of two independent αRep binders in complex with the GFP target were solved by X-ray crystallography revealing two totally different binding modes. The affinity of the selected αReps for GFP proved sufficient for practically useful applications such as pull-down experiments. αReps are disulfide free proteins and are efficiently and functionally expressed in eukaryotic cells: GFP-specific αReps are clearly sequestrated by their cognate target protein addressed to various cell compartments. These results suggest that αRep proteins with tailor-made specificity can be selected and used in living cells to track, modulate or interfere with intracellular processes. PMID:26182430

Principal component analysis as a tool for library design: a case study investigating natural products, brand-name drugs, natural product-like libraries, and drug-like libraries.

PubMed

Wenderski, Todd A; Stratton, Christopher F; Bauer, Renato A; Kopp, Felix; Tan, Derek S

2015-01-01

Principal component analysis (PCA) is a useful tool in the design and planning of chemical libraries. PCA can be used to reveal differences in structural and physicochemical parameters between various classes of compounds by displaying them in a convenient graphical format. Herein, we demonstrate the use of PCA to gain insight into structural features that differentiate natural products, synthetic drugs, natural product-like libraries, and drug-like libraries, and show how the results can be used to guide library design.

Principal Component Analysis as a Tool for Library Design: A Case Study Investigating Natural Products, Brand-Name Drugs, Natural Product-Like Libraries, and Drug-Like Libraries

PubMed Central

Wenderski, Todd A.; Stratton, Christopher F.; Bauer, Renato A.; Kopp, Felix; Tan, Derek S.

2015-01-01

Principal component analysis (PCA) is a useful tool in the design and planning of chemical libraries. PCA can be used to reveal differences in structural and physicochemical parameters between various classes of compounds by displaying them in a convenient graphical format. Herein, we demonstrate the use of PCA to gain insight into structural features that differentiate natural products, synthetic drugs, natural product-like libraries, and drug-like libraries, and show how the results can be used to guide library design. PMID:25618349

Methods for Identifying Ligands that Target Nucleic Acid Molecules and Nucleic Acid Structural Motifs

NASA Technical Reports Server (NTRS)

Childs-Disney, Jessica L. (Inventor); Disney, Matthew D. (Inventor)

2017-01-01

Disclosed are methods for identifying a nucleic acid (e.g., RNA, DNA, etc.) motif which interacts with a ligand. The method includes providing a plurality of ligands immobilized on a support, wherein each particular ligand is immobilized at a discrete location on the support; contacting the plurality of immobilized ligands with a nucleic acid motif library under conditions effective for one or more members of the nucleic acid motif library to bind with the immobilized ligands; and identifying members of the nucleic acid motif library that are bound to a particular immobilized ligand. Also disclosed are methods for selecting, from a plurality of candidate ligands, one or more ligands that have increased likelihood of binding to a nucleic acid molecule comprising a particular nucleic acid motif, as well as methods for identifying a nucleic acid which interacts with a ligand.

ESTminer: a Web interface for mining EST contig and cluster databases.

PubMed

Huang, Yecheng; Pumphrey, Janie; Gingle, Alan R

2005-03-01

ESTminer is a Web application and database schema for interactive mining of expressed sequence tag (EST) contig and cluster datasets. The Web interface contains a query frame that allows the selection of contigs/clusters with specific cDNA library makeup or a threshold number of members. The results are displayed as color-coded tree nodes, where the color indicates the fractional size of each cDNA library component. The nodes are expandable, revealing library statistics as well as EST or contig members, with links to sequence data, GenBank records or user configurable links. Also, the interface allows 'queries within queries' where the result set of a query is further filtered by the subsequent query. ESTminer is implemented in Java/JSP and the package, including MySQL and Oracle schema creation scripts, is available from http://cggc.agtec.uga.edu/Data/download.asp agingle@uga.edu.

Host-associated bacterial taxa from Chlorobi, Chloroflexi, GN02, Synergistetes, SR1, TM7, and WPS-2 Phyla/candidate divisions

PubMed Central

Camanocha, Anuj; Dewhirst, Floyd E.

2014-01-01

Background and objective In addition to the well-known phyla Firmicutes, Proteobacteria, Bacteroidetes, Actinobacteria, Spirochaetes, Fusobacteria, Tenericutes, and Chylamydiae, the oral microbiomes of mammals contain species from the lesser-known phyla or candidate divisions, including Synergistetes, TM7, Chlorobi, Chloroflexi, GN02, SR1, and WPS-2. The objectives of this study were to create phyla-selective 16S rDNA PCR primer pairs, create selective 16S rDNA clone libraries, identify novel oral taxa, and update canine and human oral microbiome databases. Design 16S rRNA gene sequences for members of the lesser-known phyla were downloaded from GenBank and Greengenes databases and aligned with sequences in our RNA databases. Primers with potential phylum level selectivity were designed heuristically with the goal of producing nearly full-length 16S rDNA amplicons. The specificity of primer pairs was examined by making clone libraries from PCR amplicons and determining phyla identity by BLASTN analysis. Results Phylum-selective primer pairs were identified that allowed construction of clone libraries with 96–100% specificity for each of the lesser-known phyla. From these clone libraries, seven human and two canine novel oral taxa were identified and added to their respective taxonomic databases. For each phylum, genome sequences closest to human oral taxa were identified and added to the Human Oral Microbiome Database to facilitate metagenomic, transcriptomic, and proteomic studies that involve tiling sequences to the most closely related taxon. While examining ribosomal operons in lesser-known phyla from single-cell genomes and metagenomes, we identified a novel rRNA operon order (23S-5S-16S) in three SR1 genomes and the splitting of the 23S rRNA gene by an I-CeuI-like homing endonuclease in a WPS-2 genome. Conclusions This study developed useful primer pairs for making phylum-selective 16S rRNA clone libraries. Phylum-specific libraries were shown to be useful for identifying previously unrecognized taxa in lesser-known phyla and would be useful for future environmental and host-associated studies. PMID:25317252

Testing of ENDF71x: A new ACE-formatted neutron data library based on ENDF/B-VII.1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gardiner, S. J.; Conlin, J. L.; Kiedrowski, B. C.

The ENDF71x library [1] is the most thoroughly tested set of ACE-format data tables ever released by the Nuclear Data Team at Los Alamos National Laboratory (LANL). It is based on ENDF/B-VII. 1, the most recently released set of evaluated nuclear data files produced by the US Cross Section Evaluation Working Group (CSEWG). A variety of techniques were used to test and verify the ENDF7 1x library before its public release. These include the use of automated checking codes written by members of the Nuclear Data Team, visual inspections of key neutron data, MCNP6 calculations designed to test data formore » every included combination of isotope and temperature as comprehensively as possible, and direct comparisons between ENDF71x and previous ACE library releases. Visual inspection of some of the most important neutron data revealed energy balance problems and unphysical discontinuities in the cross sections for some nuclides. Doppler broadening of the total cross sections with increasing temperature was found to be qualitatively correct. Test calculations performed using MCNP prompted two modifications to the MCNP6 source code and also exposed bad secondary neutron yields for {sup 231,233}Pa that are present in both ENDF/B-VII.1 and ENDF/B-VII.0. A comparison of ENDF71x with its predecessor ACE library, ENDF70, showed that dramatic changes have been made in the neutron cross section data for a number of isotopes between ENDF/B-VII.0 and ENDF/B-VII.1. Based on the results of these verification tests and the validation tests performed by Kahler, et al. [2], the ENDF71x library is recommended for use in all Monte Carlo applications. (authors)« less

The geometry of periodic knots, polycatenanes and weaving from a chemical perspective: a library for reticular chemistry.

PubMed

Liu, Yuzhong; O'Keeffe, Michael; Treacy, Michael M J; Yaghi, Omar M

2018-05-04

The geometry of simple knots and catenanes is described using the concept of linear line segments (sticks) joined at corners. This is extended to include woven linear threads as members of the extended family of knots. The concept of transitivity that can be used as a measure of regularity is explained. Then a review is given of the simplest, most 'regular' 2- and 3-periodic patterns of polycatenanes and weavings. Occurrences in crystal structures are noted but most structures are believed to be new and ripe targets for designed synthesis.

Parameterizable Library Components for SAW Devices

NASA Technical Reports Server (NTRS)

Wilson, William C.; Atkinson, Gary M.

2006-01-01

To facilitate quick fabrication of Surface Acoustic Wave (SAW) sensors we have found it necessary to develop a library of parameterizable components. This library is the first module in our strategy towards a design tool that is integrated into existing Electronic Design Automation (EDA) tools. This library is similar to the standard cell libraries found in digital design packages. The library cells allow the user to input the design parameters which automatically generate a detailed layout of the SAW component. This paper presents the results of our development of parameterizable cells for an InterDigitated Transducer (IDT), reflector, SAW delay line, and both one and two port resonators.

Modeling Your College Library after a Commercial Bookstore? The Hong Kong Design Institute Library Experience

ERIC Educational Resources Information Center

Lo, Patrick; Chiu, Dickson K. W.; Chu, Wilson

2013-01-01

The Hong Kong Design Institute (HKDI) is a leading design education institute in Hong Kong under the Vocational Training Council (VTC) group. Opened in September 2010, the HKDI Learning Resources Centre is a specialist library for the study of art and design. The mission of the HKDI Library is to support and promote the academic goals of the…

The Mayo Clinic Author Catalog: A Living Repository of Medical Knowledge

PubMed Central

Key, Jack D.; Sholtz, Katherine J.

1973-01-01

Since 1907 records have been kept of publications by staff members of the Mayo Clinic, and this information has been invaluable. The Author Catalog has proved itself such a useful tool for the Mayo Clinic that other libraries, large and small, may wish to consider adopting such a service. The Mayo medical complex is a large institution with more than 500 staff and faculty members engaged in the publication of clinical, educational, and research findings. The great amount of cross-disciplinary cooperation and interdepartmental research makes essential an up-to-date record of what is going on. The Mayo Clinic Library developed a comprehensive computerized method for identifying research and for identifying and indexing publications of Mayo staff members. At the end of 1971 more than 25,000 citations had been stored on computer tape. Images PMID:4122094

Mechanization of library procedures in the medium-sized medical library. 8. Computer applications in hospital departmental libraries.

PubMed

Howard, E; Kharibian, G

1972-07-01

To test the hypothesis that a standard library system could be designed for hospital departmental libraries, a system was developed and partially tested for four departmental libraries in the Washington University School of Medicine and Associated Hospitals. The system from determination of needs through design and evaluation, is described. The system was limited by specific constraints to control of the monograph collection. Products of control include catalog cards, accessions list, new book list, location list, fund list, missing book list, and discard book list. Sample data form and pages from a procedure manual are given, and conversion from a manual to an automated system is outlined. The question of standardization of library records and procedures is discussed, with indications of the way in which modular design, as utilized in this system, could contribute to greater flexibility in design of future systems. Reference is made to anticipating needs for organizing departmental libraries in developing regional medical library programs and to exploring the role of the departmental library in a medical library network.

The Industrial Property Rights Education in Collaboration with the Creative Product Design Education

NASA Astrophysics Data System (ADS)

Tokoro, Tetsuro; Habuchi, Hitoe; Chonan, Isao

Recently, the Advanced Courses of Electronic System Engineering and Architecture and Civil Engineering of Gifu National College of Technology have introduced a creative subject, “Creative Engineering Practice”. In this subject, students study intellectual property rights. More specifically, they learn and practice industrial proprietary rights, procedures for obtaining a patent right, how to use Industrial Property Digital Library and so forth, along with the practice of creative product design. The industrial property rights education in collaboration with the creative product design education has been carried out by the cooperation of Japan Patent Office, Japan Institute of Invention and Innovation and a patent attorney. Through the instruction of the cooperative members, great educative results have been obtained. In this paper, we will describe the contents of the subject together with its items to pursue an upward spiral of progress.

36 CFR § 1281.4 - What are the architectural and design standards for Presidential libraries?

Code of Federal Regulations, 2013 CFR

2013-07-01

... design standards for Presidential libraries? § 1281.4 Section § 1281.4 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION NARA FACILITIES PRESIDENTIAL LIBRARY FACILITIES § 1281.4 What are the architectural and design standards for Presidential libraries? The Archivist is...

Discover the Hidden Jewels in Your Library and Sharing the Wealth through Collaboration. Selected Papers from PIALA 2011, Pacific Islands Association of Libraries, Archives, and Museums Annual Conference (21st, Kosrae, Federated States of Micronesia, November 14-17, 2011)

ERIC Educational Resources Information Center

Drake, Paul B., Ed.

2012-01-01

This publication follows the tradition of publishing selected papers from Pacific Islands Association of Libraries, Archives and Museums (PIALA) annual conferences. This 21st annual conference was held in Kosrae, Federated States of Micronesia, November 14-17, 2011. The volume begins with a listing of the members of the PIALA 2011 Planning…

The Effects of Computer Anxiety and Technostress, as Functions of Resistance to Change, on the Staff of the 18 Founding OhioLINK Libraries as the OhioLINK Automated System Is Initiated.

ERIC Educational Resources Information Center

Popovich, Donna

This descriptive study surveys the staff of all 18 founding member libraries of OhioLINK to see whether or not they prefer the new system or the old one and why. The purpose of the study is to determine if resistance to change, computer anxiety and technostress can be found in libraries converting their automated systems over to the OhioLINK…

Pacific Visions: Finding, Selecting, and Using Resources for Your Libraries, Archives, and Museums. Selected Papers from PIALA 2009, Pacific Islands Association of Libraries, Archives, and Museums Annual Conference (19th, Pohnpei, Federated States of Micronesia, November 16-21, 2009)

ERIC Educational Resources Information Center

Drake, Paul B., Ed.

2011-01-01

This publication follows the tradition of publishing selected papers from Pacific Islands Association of Libraries, Archives and Museums (PIALA) annual conferences. This 19th annual conference was held in Pohnpei, Federated States of Micronesia, November 16-21, 2009. The volume begins with a listing of the members of the PIALA 2009 Planning…

Synthesis of Enantiomerically Pure 6-Substituted-Piperazine-2-Acetic Acid Esters as Intermediates for Library Production.

PubMed

Chamakuri, Srinivas; Jain, Prashi; Guduru, Shiva Krishna Reddy; Arney, Joseph Winston; MacKenzie, Kevin; Santini, Conrad; Young, Damian W

2018-05-11

Amino acids from the chiral pool have been used to produce a 24-member branch of 2,6-disubstituted piperazine scaffolds suitable for use in compound library production. Each scaffold was obtained as a single absolute stereoisomer in multi-gram quantities. Stereochemistry was confirmed by 2D NMR protocols and enantiomeric purity was determined by chiral HPLC. The scaffolds are intended for use as intermediates in parallel synthesis of small-molecule libraries.

It Can Be Done: With Advocacy, Libraries Can Thrive on Pacific Islands. Selected Papers from PIALA 2007, Pacific Islands Association of Libraries, Archives and Museums Annual Conference (17th, Tinian and Saipan, Commonwealth of the Northern Mariana Islands, November 12-17, 2007)

ERIC Educational Resources Information Center

Horie, Ruth H., Ed.

2010-01-01

This publication follows the tradition of publishing selected papers from Pacific Islands Association of Libraries, Archives and Museums (PIALA) annual conferences. The volume begins with a listing of the members of the PIALA 2007 Planning Committee, the Officers and Executive Board, and Acknowledgements, followed by the Pre-Conference Workshop…

MEDLINE end-user survey: the University of Florida experience.

PubMed

Hsu, P P

1991-01-01

The University of Florida Health Science Center Library (UF-HSCL) surveyed MEDLINE end-user activities of the faculty from the six colleges which the UF-HSCL serves. A questionnaire was developed and sent to all faculty members. The Basic SAS program was used to analyze the collected data. This survey was intended to identify the users, the reasons for faculty members not being end users, the purpose for searching MEDLINE, the information retrieval methods, the level of end-user satisfaction, and the librarian's role in information retrieval activities. Many findings from this survey were in agreement with those of the 1988 study by the National Library of Medicine.

Phylogenetic comparison of the methanogenic communities from an acidic, oligotrophic fen and an anaerobic digester treating municipal wastewater sludge.

PubMed

Steinberg, Lisa M; Regan, John M

2008-11-01

Methanogens play a critical role in the decomposition of organics under anaerobic conditions. The methanogenic consortia in saturated wetland soils are often subjected to large temperature fluctuations and acidic conditions, imposing a selective pressure for psychro- and acidotolerant community members; however, methanogenic communities in engineered digesters are frequently maintained within a narrow range of mesophilic and circumneutral conditions to retain system stability. To investigate the hypothesis that these two disparate environments have distinct methanogenic communities, the methanogens in an oligotrophic acidic fen and a mesophilic anaerobic digester treating municipal wastewater sludge were characterized by creating clone libraries for the 16S rRNA and methyl coenzyme M reductase alpha subunit (mcrA) genes. A quantitative framework was developed to assess the differences between these two communities by calculating the average sequence similarity for 16S rRNA genes and mcrA within a genus and family using sequences of isolated and characterized methanogens within the approved methanogen taxonomy. The average sequence similarities for 16S rRNA genes within a genus and family were 96.0 and 93.5%, respectively, and the average sequence similarities for mcrA within a genus and family were 88.9 and 79%, respectively. The clone libraries of the bog and digester environments showed no overlap at the species level and almost no overlap at the family level. Both libraries were dominated by clones related to uncultured methanogen groups within the Methanomicrobiales, although members of the Methanosarcinales and Methanobacteriales were also found in both libraries. Diversity indices for the 16S rRNA gene library of the bog and both mcrA libraries were similar, but these indices indicated much lower diversity in the 16S digester library than in the other three libraries.

A greater voice for academic health sciences libraries: the Association of Academic Health Sciences Libraries' vision

PubMed Central

Bunting, Alison

2003-01-01

The founders of the Association of Academic Health Sciences Libraries (AAHSL) envisioned the development of a professional organization that would provide a greater voice for academic health sciences libraries, facilitate cooperation and communication with the Association of American Medical Colleges, and create a forum for identifying problems and solutions that are common to academic health sciences libraries. This article focuses on the fulfillment of the “greater voice” vision by describing action and leadership by AAHSL and its members on issues that directly influenced the role of academic health sciences libraries. These include AAHSL's participation in the work that led to the publication of the landmark report, Academic Information in the Academic Health Sciences Center: Roles for the Library in Information Management; its contributions to the recommendations of the Physicians for the Twenty-first Century: The GPEP Report; and the joint publication with the Medical Library Association of Challenge to Action: Planning and Evaluation Guidelines for Academic Health Sciences Libraries. PMID:12883583

Discovery of Potent Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods and Structure-Based Design

DOE Office of Scientific and Technical Information (OSTI.GOV)

Friberg, Anders; Vigil, Dominico; Zhao, Bin

2012-12-17

Myeloid cell leukemia 1 (Mcl-1), a member of the Bcl-2 family of proteins, is overexpressed and amplified in various cancers and promotes the aberrant survival of tumor cells that otherwise would undergo apoptosis. Here we describe the discovery of potent and selective Mcl-1 inhibitors using fragment-based methods and structure-based design. NMR-based screening of a large fragment library identified two chemically distinct hit series that bind to different sites on Mcl-1. Members of the two fragment classes were merged together to produce lead compounds that bind to Mcl-1 with a dissociation constant of <100 nM with selectivity for Mcl-1 over Bcl-xLmore » and Bcl-2. Structures of merged compounds when complexed to Mcl-1 were obtained by X-ray crystallography and provide detailed information about the molecular recognition of small-molecule ligands binding Mcl-1. The compounds represent starting points for the discovery of clinically useful Mcl-1 inhibitors for the treatment of a wide variety of cancers.« less

Mixture-based combinatorial libraries from small individual peptide libraries: a case study on α1-antitrypsin deficiency.

PubMed

Chang, Yi-Pin; Chu, Yen-Ho

2014-05-16

The design, synthesis and screening of diversity-oriented peptide libraries using a "libraries from libraries" strategy for the development of inhibitors of α1-antitrypsin deficiency are described. The major buttress of the biochemical approach presented here is the use of well-established solid-phase split-and-mix method for the generation of mixture-based libraries. The combinatorial technique iterative deconvolution was employed for library screening. While molecular diversity is the general consideration of combinatorial libraries, exquisite design through systematic screening of small individual libraries is a prerequisite for effective library screening and can avoid potential problems in some cases. This review will also illustrate how large peptide libraries were designed, as well as how a conformation-sensitive assay was developed based on the mechanism of the conformational disease. Finally, the combinatorially selected peptide inhibitor capable of blocking abnormal protein aggregation will be characterized by biophysical, cellular and computational methods.

LIBRARY FACILITIES FOR ELEMENTARY AND SECONDARY SCHOOLS.

ERIC Educational Resources Information Center

Office of Education (DHEW), Washington, DC.

MODERN METHODS OF TEACHING REQUIRE INCREASED RESEARCH, INDEPENDENT STUDY, READING, LISTENING, AND VIEWING. NEW DESIGNS FOR LIBRARY FACILITIES ARE NECESSARY. SOME OF THE INNOVATIONS IN LIBRARY SERVICE AND DESIGN INCLUDE--THE USE OF CARRELS FOR INDIVIDUAL STUDY, PROVISION OF A LIBRARY CLASSROOM FOR USE IN TEACHING LIBRARY RESEARCH TECHNIQUES, A…

The Beautiful and the Practical: Library Interior Design for Effective Service. A Bibliography on the Theme of the LACUNY 1985 Institute.

ERIC Educational Resources Information Center

Penchansky, Mimi; Halicki-Conrad, Adam

Prepared for the 1985 Institute of the Library Association of the City University of New York (LACUNY), this bibliography on library interior design comprises the following sections: (1) Bibliographies, Guides, and Special Issues; (2) Library Buildings/General; (3) Library Buildings/Types of Libraries; (4) Planning: The Architect/Librarian…

Thesauri Used by SLA Documentation Division Members.

ERIC Educational Resources Information Center

Pope, Nolan F.; And Others

This bibliography lists 115 citations for thesauri most frequently used by members of the Special Libraries Association (SLA) Documentation Division. Entries are arranged alphabetically by author/corporate author, followed by title, imprint and/or alternate source of availability if known, date, pagination, and subject index terms assigned…

Some Thoughts on the Future of Libraries, Journals, Impact Factors, and Replicability.

PubMed

Elwood, Thomas W

2016-01-01

A report on the "The Future of Libraries" is the outcome of a year's worth of discussions among faculty members, staff, and students at the Massachusetts Institute of Technology. While its findings and recommendations still are preliminary, the report presents a vision of the library as an "open global platform" that provides access to information to help solve global challenges. Digital access already has changed the face of research, making it more efficient for individual library users. Instead of going to a library building today to find and read books and journal articles, students and faculty access, organize, and read scholarly content on their own electronic devices. This transformation-from libraries where knowledge is accessed individually through analog and digital means into ones where creation and access to knowledge are dynamically networked-will affect all aspects of the research library.

Standards for vision science libraries: 2014 revision.

PubMed

Motte, Kristin; Caldwell, C Brooke; Lamson, Karen S; Ferimer, Suzanne; Nims, J Chris

2014-10-01

This Association of Vision Science Librarians revision of the "Standards for Vision Science Libraries" aspires to provide benchmarks to address the needs for the services and resources of modern vision science libraries (academic, medical or hospital, pharmaceutical, and so on), which share a core mission, are varied by type, and are located throughout the world. Through multiple meeting discussions, member surveys, and a collaborative revision process, the standards have been updated for the first time in over a decade. While the range of types of libraries supporting vision science services, education, and research is wide, all libraries, regardless of type, share core attributes, which the standards address. The current standards can and should be used to help develop new vision science libraries or to expand the growth of existing libraries, as well as to support vision science librarians in their work to better provide services and resources to their respective users.

Accreditation of Library and Information Science Programmes in the Gulf Cooperation Council Nations

ERIC Educational Resources Information Center

Rehman, Sajjad ur

2012-01-01

This paper investigates the accreditation possibilities and prospects for the library and information science education programmes located in the six member nations of the Gulf Cooperation Council. This paper has been based on the findings of a study focused on the evaluation practices of these programmes and the perceptions of the leading…

Comparison and Evaluation of End-User Interfaces for Online Public Access Catalogs.

ERIC Educational Resources Information Center

Zumer, Maja

End-user interfaces for the online public access catalogs (OPACs) of OhioLINK, a system linking major university and research libraries in Ohio, and its 16 member libraries, accessible through the Internet, are compared and evaluated from the user-oriented perspective. A common, systematic framework was used for the scientific observation of the…

Building and Running a Collaborative Internet Filter Is Akin to a Kansas Barn Raising

ERIC Educational Resources Information Center

Reddick, Thomas

2004-01-01

The Northeast Kansas Library System's filtering project started out as a response to the passage of CIPA, the Children's Internet Protection Act, in January 2001. Originally called "onGuard," it was a service that the Northeast Kansas Library System created for its members. When the Supreme Court ruling did uphold the constitutionality…

Ending the Turf War: Circulation, Reference, and Instruction on One Team

ERIC Educational Resources Information Center

Johnson, Ken; Jennings, Susan; Hisle, Sue

2011-01-01

In January 2008, the Belk Library & Information Commons at Appalachian State University combined the Access Services staff members of the Circulation and Lower Level Service Desks with the Reference and Instruction team as part of a library-wide reorganization effort. The new team balanced what had been a staff-dominated Access Services team…

Building Use Policies. SPEC Kit 144.

ERIC Educational Resources Information Center

Coyle, Patrick

This Systems and Procedures Exchange Center (SPEC) flyer/kit addresses some of the needs of Association of Research Libraries (ARL) members regarding library building use and the aesthetics and well-being of the materials and people in the building. The kit draws upon documents gathered as part of a 1986 Quick-SPEC survey that dealt with food and…

Online Law School Video Repository: The Flash Way

ERIC Educational Resources Information Center

Fang, Wei

2009-01-01

As with many other libraries in the U.S., the Rutgers University Law Library-Newark (RULLN), where the author works as digital services librarian, offers VHS tapes and CDs to its patrons. In 2006, some faculty members asked if their lectures could be posted online with protection so that only authorized users of the university's NetID system could…

Raising the Bar: Engaging Staff and Students in a Culture of Participation

ERIC Educational Resources Information Center

Kowalski, Sue

2012-01-01

To thrive, a successful school library program needs active participation from all members of its community. As an instructional leader, the school librarian must be the one to raise the bar, not just informing other educators about resources and services, but empowering all adults to become engaged in the school library program. For example,…

How to Build a Desk Statistics Tracker in Less than an Hour Using Forms in Google Docs

ERIC Educational Resources Information Center

Carter, Sunshine; Ambrosi, Thomas

2011-01-01

The University of Minnesota-Duluth is the second largest campus in the University of Minnesota system. The UMD library, which serves more than 11,000 students and 500 faculty members, is primarily an undergraduate library. The reference team consists of eight librarians, including author Sunshine Carter, reference and electronics resources…

Access Services: Organization and Management. SPEC Kit #179.

ERIC Educational Resources Information Center

Steel, Virginia, Comp.

This Systems and Exchange Center (SPEC) kit begins with a summary by Virginia Steel of the findings of a survey of Association of Research Libraries (ARL) member libraries that was conducted in 1991 to determine the prevalence of the organizational model of access services--i.e., a department or division responsible for the services and operations…

Ohio's Foray into Evidence-Based Practice

ERIC Educational Resources Information Center

Findlay, Christine

2006-01-01

Ohio Educational Library Media Association (OELMA) has been working for many years to gather evidence in hopes of convincing their state government of the need for a certified library media specialist in every school. Its latest efforts began in 2002 when the board of OELMA applied for a grant to do a state study. Board members of OELMA, however,…

Steven MacCall: Winner of LJ's 2010 Teaching Award

ERIC Educational Resources Information Center

Berry, John N., III

2010-01-01

This article profiles Steven L. MacCall, winner of "Library Journal's" 2010 Teaching Award. An associate professor at the School of Library and Information Studies (SLIS) at the University of Alabama, Tuscaloosa, MacCall was nominated by Kathie Popadin, known as "Kpop" to the members of her cohort in the online MLIS program at SLIS. Sixteen of…

Library staff development course.

PubMed Central

Eaton, E K

1981-01-01

The Moody Medical Library at the University of Texas Medical Branch plans, presents, and evaluates regularly a staff development program for its employees, including librarians and clerical and technical staff. The program's purpose is to provide continuing education for the library staff while concurrently: (1) providing information concerning specific library services and programs; (2) illustrating the interrelationship of the departments and divisions within the library; (3) developing a sense of teamwork and loyalty; and (4) developing job pride. Staff member volunteers teach the various courses. An integral part of the program is an evaluation of the efficacy of its various components using a form developed specifically for this purpose. Participants give the majority of courses an effectiveness rating of 90% or above. PMID:7248595

Creating Cyber Libraries: An Instructional Guide for School Library Media Specialists. School Librarianship Series.

ERIC Educational Resources Information Center

Craver, Kathleen W.

This book provides school library media specialists (SLMSs) with practical guidelines and suggested Internet sites for designing cyber libraries that are reflective of their school's research, curriculum, and recreational reading needs. An introduction provides SLMSs with a rationale for designing cyber libraries. Chapter 1, Cyber Library…

Touring the Campus Library from the World Wide Web.

ERIC Educational Resources Information Center

Mosley, Pixey Anne; Xiao, Daniel

1996-01-01

The philosophy, design, implementation and evaluation of a World Wide Web-accessible Virtual Library Tour of Texas A & M University's Evans Library is presented. Its design combined technical computer issues and library instruction expertise. The tour can be used to simulate a typical walking tour through the library or heading directly to a…

Design and Usability of Digital Libraries: Case Studies in the Asia Pacific

ERIC Educational Resources Information Center

Theng, Yin-Leng, Ed.; Foo, Schubert, Ed.

2005-01-01

This book showcases some of the best digital library practices from organizations in the Asia Pacific. Particular emphasis has been placed on the design, use and usability of digital libraries. Not only are digital libraries examined, but related technologies, the management of knowledge in digital libraries, and the associated usability and…

Balancing novelty with confined chemical space in modern drug discovery.

PubMed

Medina-Franco, José L; Martinez-Mayorga, Karina; Meurice, Nathalie

2014-02-01

The concept of chemical space has broad applications in drug discovery. In response to the needs of drug discovery campaigns, different approaches are followed to efficiently populate, mine and select relevant chemical spaces that overlap with biologically relevant chemical spaces. This paper reviews major trends in current drug discovery and their impact on the mining and population of chemical space. We also survey different approaches to develop screening libraries with confined chemical spaces balancing physicochemical properties. In this context, the confinement is guided by criteria that can be divided in two broad categories: i) library design focused on a relevant therapeutic target or disease and ii) library design focused on the chemistry or a desired molecular function. The design and development of chemical libraries should be associated with the specific purpose of the library and the project goals. The high complexity of drug discovery and the inherent imperfection of individual experimental and computational technologies prompt the integration of complementary library design and screening approaches to expedite the identification of new and better drugs. Library design approaches including diversity-oriented synthesis, biological-oriented synthesis or combinatorial library design, to name a few, and the design of focused libraries driven by target/disease, chemical structure or molecular function are more efficient if they are guided by multi-parameter optimization. In this context, consideration of pharmaceutically relevant properties is essential for balancing novelty with chemical space in drug discovery.

Combining history of medicine and library instruction: an innovative approach to teaching database searching to medical students.

PubMed

Timm, Donna F; Jones, Dee; Woodson, Deidra; Cyrus, John W

2012-01-01

Library faculty members at the Health Sciences Library at the LSU Health Shreveport campus offer a database searching class for third-year medical students during their surgery rotation. For a number of years, students completed "ten-minute clinical challenges," but the instructors decided to replace the clinical challenges with innovative exercises using The Edwin Smith Surgical Papyrus to emphasize concepts learned. The Surgical Papyrus is an online resource that is part of the National Library of Medicine's "Turning the Pages" digital initiative. In addition, vintage surgical instruments and historic books are displayed in the classroom to enhance the learning experience.

Automated design of degenerate codon libraries.

PubMed

Mena, Marco A; Daugherty, Patrick S

2005-12-01

Degenerate codon libraries are frequently used in protein engineering and evolution studies but are often limited to targeting a small number of positions to adequately limit the search space. To mitigate this, codon degeneracy can be limited using heuristics or previous knowledge of the targeted positions. To automate design of libraries given a set of amino acid sequences, an algorithm (LibDesign) was developed that generates a set of possible degenerate codon libraries, their resulting size, and their score relative to a user-defined scoring function. A gene library of a specified size can then be constructed that is representative of the given amino acid distribution or that includes specific sequences or combinations thereof. LibDesign provides a new tool for automated design of high-quality protein libraries that more effectively harness existing sequence-structure information derived from multiple sequence alignment or computational protein design data.

SLA Triennial Salary Survey, 1989.

ERIC Educational Resources Information Center

Special Libraries Association, Washington, DC.

The objectives of the 8th triennial salary survey of Special Library Association (SLA) members were to: (1) obtain systematic accurate information about the salaries of special librarians and information personnel; (2) establish a data bank from which inquiries about salaries can be answered for members of the SLA, persons engaged in personnel and…

Phylogenetic characterization of microbial communities that reductively dechlorinate TCE based upon a combination of molecular techniques.

PubMed

Richardson, Ruth E; Bhupathiraju, Vishvesh K; Song, Donald L; Goulet, Tanuja A; Alvarez-Cohen, Lisa

2002-06-15

An anaerobic microbial consortium (referred to as ANAS) that reductively dechlorinates trichloroethene (TCE) completely to ethene with the transient production of cisdichloroethene (cDCE) and vinyl chloride was enriched from contaminated soil obtained from Alameda Naval Air Station. ANAS uses lactate as its electron donor and has been functionally stable for over 2 years. Following a brief exposure to oxygen, a subculture (designated VCC) derived from ANAS could dechlorinate TCE only to vinyl chloride with lactate as its electron donor. Three molecular methods were used concurrently to characterize the community structure of ANAS and VCC: clone library construction/clone sequencing, terminal restriction fragment length polymorphism (T-RFLP) analysis, and fluorescent in situ hybridization (FISH) with rRNA probes. The community structure of ANAS did not change significantly over the course of a single feeding/dechlorination cycle, and only minor fluctuations occurred over many feeding cycles spanning the course of 1 year. Clone libraries and T-RFLP analyses suggested that ANAS was dominated by populations belonging to three phylogenetic groups: Dehalococcoides species, Desulfovibrio species, and members of the Clostridiaceae (within the low G + C Gram-positives). FISH results suggest that members of the Cytophaga/Flavobacterium/Bacteroides (CFB) cluster and high G + C Gram-positives (HGCs) were numerically important in ANAS despite their under-representation in the clone libraries. Parallel analyses of VCC samples suggested that Dehalococcoides species and Clostridiaceae were only minor populations in this community. Instead, VCC had increased populations of organisms in the beta and gamma subclasses of the Proteobacteria as well as significant populations of organisms in the CFB cluster. It is possible that symbiotic interactions are occurring between some of ANAS's phylogenetic groups under the enrichment conditions, including interspecies hydrogen transfer from Desulfovibrio species to Dehalococcoides species. However, the nucleic acid-based analyses performed here would need to be supplemented with chemical species data in order to test any hypotheses about functional roles of various community members. Additionally, these results suggest that an organism outside the Dehalococcoides genus may be capable of dechlorinating cDCE to vinyl chloride.

The Vendors' Corner: Biblio-Techniques' Library and Information System (BLIS).

ERIC Educational Resources Information Center

Library Software Review, 1984

1984-01-01

Describes online catalog and integrated library computer system designed to enhance Washington Library Network's software. Highlights include system components; implementation options; system features (integrated library functions, database design, system management facilities); support services (installation and training, software maintenance and…

I've Been Framed! Designing a Library Web Site Within a Government Frame

ERIC Educational Resources Information Center

Houghton, Sarah

2005-01-01

Often, because of political reasons, a library's site must be designed within the frame of another organization's. In this article, the author, the e-services librarian for the Marin County Free Library in San Rafael, California, details her experience of designing a library website within the frame--and within the rules and limitations--of the…

Using Action Research to Assess and Advocate for Innovative School Library Design

ERIC Educational Resources Information Center

Harper, Meghan; Deskins,Liz

2015-01-01

This article describes a collaborative project designed to use action research to assess and advocate for innovative design changes in a school library. The high school library was in its fifth year of service, and yet the layout of the library was not meeting the learning and technological needs of 21st-century high school students. The purpose…

Low track height standard cell design in iN7 using scaling boosters

NASA Astrophysics Data System (ADS)

Sherazi, S. M. Y.; Jha, C.; Rodopoulos, D.; Debacker, P.; Chava, B.; Matti, L.; Bardon, M. G.; Schuddinck, P.; Raghavan, P.; Gerousis, V.; Spessot, A.; Verkest, D.; Mocuta, A.; Kim, R. H.; Ryckaert, J.

2017-04-01

In this paper, standard cell design for iN7 CMOS platform technology targeting the tightest contacted poly pitch (CPP) of 42 nm and a metal pitch of 32 nm in the FinFET technology is presented. Three standard cell architectures for iN7, a 7.5-Track library, 6.5-Track library, and 6-Track library have been designed. Scaling boosters are introduced for the libraries progressively: first an extra MOL layer to enable an efficient layout of the three libraries starting with 7.5-Track library; second, fully self aligned gate contact is introduced for 6.5 and 6-Track library and third, 6-Track cell design includes a buried rail track for supply. The 6-Track cells are on average 5% and 45% smaller than the 6.5 and 7.5-Track cells, respectively.

Checklist of Library Building Design Considerations. Fourth Edition.

ERIC Educational Resources Information Center

Sannwald, William W.

This checklist serves as a guide during various stages of a library design process to help ensure that all needed spaces and functions are included, to help enable the evaluation of existing library spaces as part of a library's needs assessment process, and to help provide data and support to the library in presentations that might be made to…

Circulation and Library Design: The Influence of 'Movement' on the Layout of Libraries.

ERIC Educational Resources Information Center

Marples, D. L.; Knell, K. A.

The movement of people in a library is inevitably noisy and also creates a visual distraction for the reader. If the provision of quiet areas where readers can work undisturbed is an important criterion of library design, the traffic patterns generated in a library by the disposition of the various facilities - stacks, periodicals, reference…

Planning for a New Generation of Public Library Buildings. The Greenwood Library Management Collection.

ERIC Educational Resources Information Center

McCabe, Gerard B.

This book on public library design and construction contains the following chapters: (1) "Beginning the Plan"; (2) "Data for Planning"; (3) "Location: Finding a Site"; (4) "Interior Design"; (5) "Furnishing and Equipping the Library and Its Environs"; (6) "Other Views," including "Using Small College Library Planning Techniques in Public Library…

Alabama's Public Library as Seen by Patrons, Administrators and Trustees. Executive Summary.

ERIC Educational Resources Information Center

Kaske, Neal; And Others

Conducted to obtain information for use in developing a revised five-year plan of library service for the state of Alabama, this study was designed to determine the priorities of the state's public libraries as perceived by librarians, chairpersons of library boards of trustees, and library users. Two survey instruments were designed and…

Research on natural lighting in reading spaces of university libraries in Jinan under the perspective of energy-efficiency

NASA Astrophysics Data System (ADS)

Yang, Zengzhang

2017-11-01

The natural lighting design in the reading spaces of university libraries not only influences physical and mental health of readers but also concerns the energy consumption of the libraries. The scientific and rational design of natural lighting is the key to the design of energy saving for physical environment of the reading space. The paper elaborates the present situation and existed problems of natural lighting in reading spaces of university libraries across Jinan region based on characteristics of light climate of Jinan region and concrete utilization of reading spaces in university libraries, and combining field measurement, survey, research and data analysis of reading spaces in Shandong Women’s University’s library. The paper, under the perspective of energy-efficiency, puts forward proposals to improve natural lighting in the reading spaces of university libraries from five aspects, such as adjustment of interior layout, optimization of outer windows design, employment of the reflector panel, design lighting windows on inner walls and utilization of adjustable sun shading facilities.

Structure-based design of combinatorial mutagenesis libraries

PubMed Central

Verma, Deeptak; Grigoryan, Gevorg; Bailey-Kellogg, Chris

2015-01-01

The development of protein variants with improved properties (thermostability, binding affinity, catalytic activity, etc.) has greatly benefited from the application of high-throughput screens evaluating large, diverse combinatorial libraries. At the same time, since only a very limited portion of sequence space can be experimentally constructed and tested, an attractive possibility is to use computational protein design to focus libraries on a productive portion of the space. We present a general-purpose method, called “Structure-based Optimization of Combinatorial Mutagenesis” (SOCoM), which can optimize arbitrarily large combinatorial mutagenesis libraries directly based on structural energies of their constituents. SOCoM chooses both positions and substitutions, employing a combinatorial optimization framework based on library-averaged energy potentials in order to avoid explicitly modeling every variant in every possible library. In case study applications to green fluorescent protein, β-lactamase, and lipase A, SOCoM optimizes relatively small, focused libraries whose variants achieve energies comparable to or better than previous library design efforts, as well as larger libraries (previously not designable by structure-based methods) whose variants cover greater diversity while still maintaining substantially better energies than would be achieved by representative random library approaches. By allowing the creation of large-scale combinatorial libraries based on structural calculations, SOCoM promises to increase the scope of applicability of computational protein design and improve the hit rate of discovering beneficial variants. While designs presented here focus on variant stability (predicted by total energy), SOCoM can readily incorporate other structure-based assessments, such as the energy gap between alternative conformational or bound states. PMID:25611189

Structure-based design of combinatorial mutagenesis libraries.

PubMed

Verma, Deeptak; Grigoryan, Gevorg; Bailey-Kellogg, Chris

2015-05-01

The development of protein variants with improved properties (thermostability, binding affinity, catalytic activity, etc.) has greatly benefited from the application of high-throughput screens evaluating large, diverse combinatorial libraries. At the same time, since only a very limited portion of sequence space can be experimentally constructed and tested, an attractive possibility is to use computational protein design to focus libraries on a productive portion of the space. We present a general-purpose method, called "Structure-based Optimization of Combinatorial Mutagenesis" (SOCoM), which can optimize arbitrarily large combinatorial mutagenesis libraries directly based on structural energies of their constituents. SOCoM chooses both positions and substitutions, employing a combinatorial optimization framework based on library-averaged energy potentials in order to avoid explicitly modeling every variant in every possible library. In case study applications to green fluorescent protein, β-lactamase, and lipase A, SOCoM optimizes relatively small, focused libraries whose variants achieve energies comparable to or better than previous library design efforts, as well as larger libraries (previously not designable by structure-based methods) whose variants cover greater diversity while still maintaining substantially better energies than would be achieved by representative random library approaches. By allowing the creation of large-scale combinatorial libraries based on structural calculations, SOCoM promises to increase the scope of applicability of computational protein design and improve the hit rate of discovering beneficial variants. While designs presented here focus on variant stability (predicted by total energy), SOCoM can readily incorporate other structure-based assessments, such as the energy gap between alternative conformational or bound states. © 2015 The Protein Society.

Scalable total synthesis and comprehensive structure-activity relationship studies of the phytotoxin coronatine.

PubMed

Littleson, Mairi M; Baker, Christopher M; Dalençon, Anne J; Frye, Elizabeth C; Jamieson, Craig; Kennedy, Alan R; Ling, Kenneth B; McLachlan, Matthew M; Montgomery, Mark G; Russell, Claire J; Watson, Allan J B

2018-03-16

Natural phytotoxins are valuable starting points for agrochemical design. Acting as a jasmonate agonist, coronatine represents an attractive herbicidal lead with novel mode of action, and has been an important synthetic target for agrochemical development. However, both restricted access to quantities of coronatine and a lack of a suitably scalable and flexible synthetic approach to its constituent natural product components, coronafacic and coronamic acids, has frustrated development of this target. Here, we report gram-scale production of coronafacic acid that allows a comprehensive structure-activity relationship study of this target. Biological assessment of a >120 member library combined with computational studies have revealed the key determinants of potency, rationalising hypotheses held for decades, and allowing future rational design of new herbicidal leads based on this template.

No Gifted Student Left Behind: Building a High School Library Media Center for the Gifted Student

ERIC Educational Resources Information Center

Graboyes, Alanna S.

2007-01-01

The Library Media Center of the Maggie L. Walker Governor's School, a high school specializing in Government and International Studies, located in Richmond, Virginia, serves close to 650 gifted students in grades 9-12. The skills of Governor's students range from the neophyte ninth-grade researcher to experienced faculty members embarking on their…

The Qur'an and the Academic Library: Circulation and Storage Issues with Holy Books

ERIC Educational Resources Information Center

Long, Dallas

2010-01-01

This article addresses concerns raised by members of the local Muslim community regarding copies of the Qur'an in the circulating collections at Milner Library, Illinois State University. The librarians conducted an analysis of the collection of holy books and investigated the rules and traditions of the Islamic faith that govern the care and…

Democratizing Human Genome Project Information: A Model Program for Education, Information and Debate in Public Libraries.

ERIC Educational Resources Information Center

Pollack, Miriam

The "Mapping the Human Genome" project demonstrated that librarians can help whomever they serve in accessing information resources in the areas of biological and health information, whether it is the scientists who are developing the information or a member of the public who is using the information. Public libraries can guide library…

Coaching in the Library: A Management Strategy for Achieving Excellence. Second Edition

ERIC Educational Resources Information Center

Metz, Ruth F.

2010-01-01

Experienced librarian and coach Ruth Metz outlines a focused and results-oriented plan for achieving the best results from staff members through a coaching style of management. Real-world examples and coaching scenarios specific to library work will help librarians: (1) Be both a coach and a player by learning the terminology and techniques; (2)…

The New Role of Librarians and Libraries: Removing the Silence Signs

ERIC Educational Resources Information Center

Carriuolo, Nancy; Reis, Tovah

2015-01-01

An increasing number of institutions are freeing up shelf space in their libraries and moving in student services as well as a coffee shop and other lures such as flexible seating arrangements. Librarians are taking down the silence signs in all but the quiet study room and urging members of the academic community to meet, talk, research and…

Using Buttons to Better Manage Online Presence: How One Academic Institution Harnessed the Power of Flair

ERIC Educational Resources Information Center

Dority Baker, Marcia L.

2013-01-01

This article provides a case study of how the University of Nebraska College of Law and Schmid Law Library use "buttons" to manage Law College faculty members' and librarians' online presence. Since Google is the primary search engine used to find information, it is important that librarians and libraries assist Web site visitors in…

Education for Management in Central America. The Role of the Library of the Instituto Centroamericano de Administracion de Empresas

ERIC Educational Resources Information Center

Bloch, Thomas

1973-01-01

The institute, established in 1968, is a multinational organization for education in management at the post-graduate level. Its library, with five staff members, now has 4,000 volumes and receives 300 periodical publications: it should eventually become a Central American business and economic management information and research center. (Author/SJ)

Collaboration among Faculty Members and Community Partners: Increasing the Quality of Online Library and Information Science Graduate Programs through Academic Service-Learning

ERIC Educational Resources Information Center

Angel, Christine M.

2016-01-01

Finding innovative ways to deliver effective classroom instruction resulting in demonstration of student proficiency of the eight American Library Association core competencies within the online learning environment is challenging. While the use of technology is very important in the delivery of course content, focusing on the pedagogy of teaching…

Libraries, Archives, and Museums Helping Create Futures: Building on Culture, Knowledge, and Information through Collaboration and Resource Sharing. Selected Papers from PIALA 2010, Pacific Islands Association of Libraries, Archives, and Museums Annual Conference (20th, Weno, Chuuk State, Federated States of Micronesia, November 15-19, 2010)

ERIC Educational Resources Information Center

Drake, Paul B., Ed.

2012-01-01

This publication follows the tradition of publishing selected papers from Pacific Islands Association of Libraries, Archives and Museums (PIALA) annual conferences. This 20th annual conference was held in Weno, Chuuk State, Federated States of Micronesia, November 15-19, 2010. The volume begins with a listing of the members of the PIALA 2010…

The effectiveness of interventions to meet family needs of critically ill patients in an adult intensive care unit: a systematic review.

PubMed

Kynoch, Kate; Chang, Anne M; Coyer, Fiona

Background Attending to the needs of family members of critically ill patients is an important and necessary step in providing appropriate care for both the patient and the family. An initial search of the Cochrane and Joanna Briggs Institute Libraries did not reveal any published systematic reviews recommending effective interventions for addressing family needs of critically ill patients in an acute intensive care unit.Objectives This systematic review aims to establish best practice in addressing the needs of family members with a relative admitted to an adult critical care unit.Search strategy An extensive search of the major databases was conducted. Databases searched included: MEDLINE, CINAHL, psycINFO, Health source, Web of science, EMBASE, the Cochrane library and Database of abstracts of reviews of effects (DARE) as well as Pubmed. The search included published and unpublished studies and papers in English from 1980-2010.Selection criteria This review considered any randomised controlled trials that evaluated the effectiveness of interventions in addressing family needs of critically ill patients in an adult intensive care unit. In the absence of randomised controlled trials, other research designs such as quasi-experimental as well as before and after studies were considered for inclusion in the narrative summary to enable the identification of current approaches and possible future strategies for addressing family needs of critically ill patients.Assessment of quality Each included study was assessed by two independent reviewers using the appropriate appraisal checklist developed by the Joanna Briggs Institute.Data collection and analysis Data was extracted from the papers included in this review using standardised data extraction tools from the Joanna Briggs Institute Meta Analysis of Statistics Assessment and Review Instrument package. The studies included in this review were not suitable for meta-analysis and therefore the results are presented in narrative form.Results Fourteen studies and one dissertation met the inclusion criteria and were included in the review. There were 12 quasi-experimental studies identified including 8 two or three group, pre-test/post-test studies; 1 one-way between subjects design; 1 interrupted time series and 1 two-group comparative design study. The dissertation was a quasi-experimental three group pre-test/post-test design. There were 3 prospective randomised trials included. The evidence identified includes: the use of support groups for family members of patients admitted to an intensive care unit, structured communication and/or education programs for family members, the use of leaflets or brochures to meet family information needs and open or more flexible visiting hours.Conclusion/Recommendations This review makes several recommendations for clinical practice to address family needs of patients admitted to a critical care unit, however this review highlights the need for significant further research in this area. Future intervention studies focusing on family needs could include: the use of technology such as DVD's and SMS for informing families and interventions specifically designed to improve family comfort.

Mapping of Drug-like Chemical Universe with Reduced Complexity Molecular Frameworks.

PubMed

Kontijevskis, Aleksejs

2017-04-24

The emergence of the DNA-encoded chemical libraries (DEL) field in the past decade has attracted the attention of the pharmaceutical industry as a powerful mechanism for the discovery of novel drug-like hits for various biological targets. Nuevolution Chemetics technology enables DNA-encoded synthesis of billions of chemically diverse drug-like small molecule compounds, and the efficient screening and optimization of these, facilitating effective identification of drug candidates at an unprecedented speed and scale. Although many approaches have been developed by the cheminformatics community for the analysis and visualization of drug-like chemical space, most of them are restricted to the analysis of a maximum of a few millions of compounds and cannot handle collections of 10 8 -10 12 compounds typical for DELs. To address this big chemical data challenge, we developed the Reduced Complexity Molecular Frameworks (RCMF) methodology as an abstract and very general way of representing chemical structures. By further introducing RCMF descriptors, we constructed a global framework map of drug-like chemical space and demonstrated how chemical space occupied by multi-million-member drug-like Chemetics DNA-encoded libraries and virtual combinatorial libraries with >10 12 members could be analyzed and mapped without a need for library enumeration. We further validate the approach by performing RCMF-based searches in a drug-like chemical universe and mapping Chemetics library selection outputs for LSD1 targets on a global framework chemical space map.

Building a High-Tech Library in a Period of Austerity.

ERIC Educational Resources Information Center

Bazillion, Richard J.; Scott, Sue

1991-01-01

Describes the planning process for designing a new library for Algoma University College (Ontario). Topics discussed include the building committee, library policy, design considerations, an electric system that supports computer technology, library automation, the online public access catalog (OPAC), furnishings and interior environment, and…

Research on Energy-saving Shape Design of High School Library Building in Cold Region

NASA Astrophysics Data System (ADS)

Hui, Zhao; Weishuang, Xie; Zirui, Tong

2017-11-01

Considering climatic characteristics in cold region, existing high school libraries in Changchun are researched according to investigation of real conditions of these library buildings. Mathematical analysis and CAD methods are used to summarize the relation between building shape and building energy saving of high school library. Strategies are put forward for sustainable development of high school library building in cold region, providing reliable design basis for construction of high school libraries in Changchun.

Standards for vision science libraries: 2014 revision

PubMed Central

Motte, Kristin; Caldwell, C. Brooke; Lamson, Karen S.; Ferimer, Suzanne; Nims, J. Chris

2014-01-01

Objective: This Association of Vision Science Librarians revision of the “Standards for Vision Science Libraries” aspires to provide benchmarks to address the needs for the services and resources of modern vision science libraries (academic, medical or hospital, pharmaceutical, and so on), which share a core mission, are varied by type, and are located throughout the world. Methods: Through multiple meeting discussions, member surveys, and a collaborative revision process, the standards have been updated for the first time in over a decade. Results: While the range of types of libraries supporting vision science services, education, and research is wide, all libraries, regardless of type, share core attributes, which the standards address. Conclusions: The current standards can and should be used to help develop new vision science libraries or to expand the growth of existing libraries, as well as to support vision science librarians in their work to better provide services and resources to their respective users. PMID:25349547

The book availability study as an objective measure of performance in a health sciences library.

PubMed Central

Kolner, S J; Welch, E C

1985-01-01

In its search for an objective overall diagnostic evaluation, the University of Illinois Library of the Health Sciences' Program Evaluation Committee selected a book availability measure; it is easy to administer and repeat, results are reproducible, and comparable data exist for other academic and health sciences libraries. The study followed the standard methodology in the literature with minor modifications. Patrons searching for particular books were asked to record item(s) needed and the outcome of the search. Library staff members then determined the reasons for failures in obtaining desired items. The results of the study are five performance scores. The first four represent the percentage probability of a library's operating with ideal effectiveness; the last provides an overall performance score. The scores of the Library of the Health Sciences demonstrated no unusual availability problems. The study was easy to implement and provided meaningful, quantitative, and objective data. PMID:3995202

A credit-card library approach for disrupting protein-protein interactions.

PubMed

Xu, Yang; Shi, Jin; Yamamoto, Noboru; Moss, Jason A; Vogt, Peter K; Janda, Kim D

2006-04-15

Protein-protein interfaces are prominent in many therapeutically important targets. Using small organic molecules to disrupt protein-protein interactions is a current challenge in chemical biology. An important example of protein-protein interactions is provided by the Myc protein, which is frequently deregulated in human cancers. Myc belongs to the family of basic helix-loop-helix leucine zipper (bHLH-ZIP) transcription factors. It is biologically active only as heterodimer with the bHLH-ZIP protein Max. Herein, we report a new strategy for the disruption of protein-protein interactions that has been corroborated through the design and synthesis of a small parallel library composed of 'credit-card' compounds. These compounds are derived from a planar, aromatic scaffold and functionalized with four points of diversity. From a 285 membered library, several hits were obtained that disrupted the c-Myc-Max interaction and cellular functions of c-Myc. The IC50 values determined for this small focused library for the disruption of Myc-Max dimerization are quite potent, especially since small molecule antagonists of protein-protein interactions are notoriously difficult to find. Furthermore, several of the compounds were active at the cellular level as shown by their biological effects on Myc action in chicken embryo fibroblast assays. In light of our findings, this approach is considered a valuable addition to the armamentarium of new molecules being developed to interact with protein-protein interfaces. Finally, this strategy for disrupting protein-protein interactions should prove applicable to other families of proteins.

DataCite - Making data sets citable

NASA Astrophysics Data System (ADS)

Brase, J.

2013-12-01

The scientific and information communities have largely mastered the presentation of, and linkages between, text-based electronic information by assigning persistent identifiers to give scientific literature unique identities and accessibility. Knowledge, as published through scientific literature, is however often the last step in a process originating from scientific research data. Today scientists are using simulation, observational, and experimentation techniques that yield massive quantities of research data. These data are analysed, synthesised, interpreted, and the outcome of this process is generally published as a scientific article. Access to the original data as the foundation of knowledge has become an important issue throughout the world and different projects have started to find solutions. Global collaboration and scientific advances could be accelerated through broader access to scientific research data. In other words, data access could be revolutionized through the same technologies used to make textual literature accessible. The most obvious opportunity to broaden visibility of and access to research data is to integrate its access into the medium where it is most often cited: electronic textual information. Besides this opportunity, it is important, irrespective of where they are cited, for research data to have an internet identity. Since 2005, the German National Library of Science and Technology (TIB) has offered a successful Digital Object Identifier (DOI) registration service for persistent identification of research data. Since 2010 these services are offered by the global consortium DataCite, carried by 17 member organisations from 12 different countries: The German National Library of Science and Technology (TIB), the German National Library of Medicine (ZB MED), the German National Library of Economics (ZBW) and the German GESIS - Leibniz Institute for the Social Sciences. Additional European members are: The Library of the ETH Zürich in Switzerland, the Library of TU Delft, from the Netherlands, the L'Institut de l'Information Scientifique et Technique (INIST) from France, The technical Information Center of Denmark, The British Library, the Sedish National Data Service (SND), the Conferenza dei Rettori delle Università Italiane (CRUI) from Italy. North America is represented through: the California Digital Library, the Office of Scientific and Technical Information (OSTI), the Purdue University and the Canada Institute for Scientific and Technical Information (CISTI). Furthermore the Australian National Data Service (ANDS) and the National Research Council of Thailand (NRCT) are members. DataCite offers through its members DOI registration for data centers, currently over 2 million objects have been registered with a DOI name and are available through a central search portal at http://search.datacite.org . Based on the DOI registration DataCite offers a variety of services such as a detailed statistic portal of the number of DOI names registered and resolved (http://stats.datacite.org). In June 2012 DataCite and the STM association (http://www.stm-assoc.org) signed a joint statement to encourage publishers and data centers to link articles and underlying data (http://www.datacite.org/node/65 )

Classification System and Information Services in the Library of SAO RAS

NASA Astrophysics Data System (ADS)

Shvedova, G. S.

The classification system used at SAO RAS is described. It includes both special determinants from UDC (Universal Decimal Classification) and newer tables with astronomical terms from the Library-Bibliographical Classification (LBC). The classification tables are continually modified, and new astronomical terms are introduced. At the present time the information services of the scientists is fulfilled with the help of the Abstract Journal Astronomy, Astronomy and Astrophysics Abstracts, catalogues and card indexes of the library. Based on our classification system and The Astronomy Thesaurus completed by R.M. Shobbrook and R.R. Shobbrook the development of a database for the library has been started, which allows prompt service of the observatory's staff members.

A natural product based DOS library of hybrid systems.

PubMed

Prabhu, Ganesh; Agarwal, Shalini; Sharma, Vijeta; Madurkar, Sanjay M; Munshi, Parthapratim; Singh, Shailja; Sen, Subhabrata

2015-05-05

Here we described a natural product inspired modular DOS strategy for the synthesis of a library of hybrid systems that are structurally and stereochemically disparate. The main scaffold is a pyrroloisoquinoline motif, that is synthesized from tandem Pictet-Spengler lactamization. The structural diversity is generated via "privileged scaffolds" that are attached at the appropriate site of the motif. Screening of the library compounds for their antiplasmodial activity against chloroquine sensitive 3D7 cells indicated few compounds with moderate activity (20-50 μM). A systematic comparison of structural intricacy between the library members and a natural product dataset obtained from ZINC(®) revealed comparable complexity. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

36 CFR 702.3 - Demonstrations.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 702.3 Parks, Forests, and Public Property LIBRARY OF CONGRESS CONDUCT ON LIBRARY PREMISES § 702.3 Demonstrations. (a) Library buildings and grounds are designated as limited public forums, except for those areas designated as nonpublic forums. However, only Library grounds (defined in 2 U.S.C. 167j), not buildings, may...

36 CFR 702.3 - Demonstrations.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 702.3 Parks, Forests, and Public Property LIBRARY OF CONGRESS CONDUCT ON LIBRARY PREMISES § 702.3 Demonstrations. (a) Library buildings and grounds are designated as limited public forums, except for those areas designated as nonpublic forums. However, only Library grounds (defined in 2 U.S.C. 167j), not buildings, may...

36 CFR § 702.3 - Demonstrations.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Section § 702.3 Parks, Forests, and Public Property LIBRARY OF CONGRESS CONDUCT ON LIBRARY PREMISES § 702.3 Demonstrations. (a) Library buildings and grounds are designated as limited public forums, except for those areas designated as nonpublic forums. However, only Library grounds (defined in 2 U.S.C...

36 CFR 702.3 - Demonstrations.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 702.3 Parks, Forests, and Public Property LIBRARY OF CONGRESS CONDUCT ON LIBRARY PREMISES § 702.3 Demonstrations. (a) Library buildings and grounds are designated as limited public forums, except for those areas designated as nonpublic forums. However, only Library grounds (defined in 2 U.S.C. 167j), not buildings, may...

36 CFR 702.3 - Demonstrations.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 702.3 Parks, Forests, and Public Property LIBRARY OF CONGRESS CONDUCT ON LIBRARY PREMISES § 702.3 Demonstrations. (a) Library buildings and grounds are designated as limited public forums, except for those areas designated as nonpublic forums. However, only Library grounds (defined in 2 U.S.C. 167j), not buildings, may...

Designing Public Library Websites for Teens: A Conceptual Model

ERIC Educational Resources Information Center

Naughton, Robin Amanda

2012-01-01

The main goal of this research study was to develop a conceptual model for the design of public library websites for teens (TLWs) that would enable designers and librarians to create library websites that better suit teens' information needs and practices. It bridges a gap in the research literature between user interface design in human-computer…

Library as a Partner in Co-Designing Learning Spaces: A Case Study at Tampere University of Technology, Finland

ERIC Educational Resources Information Center

Tevaniemi, Johanna; Poutanen, Jenni; Lähdemäki, Riitta

2015-01-01

This article presents a case of co-designed temporary learning spaces at a Finnish academic library, together with the results of a user-survey. The experimental development of the multifunctional spaces offered an opportunity for the library to collaborate with its parent organisation thus broadening the role of the library. Hence, library can be…

Designing an Academic Library as a Place and a Space: How a Robotic Storage System Will Create a 21st Century Library Design

ERIC Educational Resources Information Center

Bostick, Sharon L.; Irwin, Bryan

2012-01-01

Renovating, expanding or building new libraries today is a challenge on several levels. Libraries in general are faced with image issues, such as the assumption that a library building exists only to house print material followed by the equally erroneous assumption that everything is now available online, thus rendering a physical building…

Health sciences library building projects: 1994 survey.

PubMed Central

Ludwig, L

1995-01-01

Designing and building new or renovated space is time consuming and requires politically sensitive discussions concerning a number of both long-term and immediate planning issues. The Medical Library Association's fourth annual survey of library building projects identified ten health sciences libraries that are planning, expanding, or constructing new facilities. Two projects are in predesign stages, four represent new construction, and four involve renovations to existing libraries. The Texas Medical Association Library, the King Faisal Specialist Hospital and Research Centre Library, and the Northwestern University Galter Health Sciences Library illustrate how these libraries are being designed for the future and take into account areas of change produced by new information technologies, curricular trends, and new ways to deliver library services. Images PMID:7599586

Data at Risk and Research Libraries

NASA Astrophysics Data System (ADS)

Choudhury, S.

2017-12-01

Research libraries have recently engaged in data rescue events amidst growing concerns about access to federal data sets. While these efforts are well intentioned, libraries run the risk of ignoring a long established history of activities and accomplishments by other communities focused on data at risk, many of which are represented at forums such as AGU. Under the auspices of the Data Conservancy, the Sheridan Libraries at Johns Hopkins University hosted an event in July 2017 that convened members of various communities including ESIP, RDA, Data Rescue Boulder, Association of Research Libraries, the Fedora repository platform, the Open Science Framework and the Interplanetary File System or IPFS (via the Data Together Network). This group identified a potential role for research libraries to partner with existing players in the data at risk community by focusing on a distributed preservation network as part of a coordinated collection development program. This session will offer an opportunity to hear about this potential role for research libraries and to provide feedback about its viability and utility.

Development of a standardized, citywide process for managing smart-pump drug libraries.

PubMed

Walroth, Todd A; Smallwood, Shannon; Arthur, Karen; Vance, Betsy; Washington, Alana; Staublin, Therese; Haslar, Tammy; Reddan, Jennifer G; Fuller, James

2018-06-15

Development and implementation of an interprofessional consensus-driven process for review and optimization of smart-pump drug libraries and dosing limits are described. The Indianapolis Coalition for Patient Safety (ICPS), which represents 6 Indianapolis-area health systems, identified an opportunity to reduce clinically insignificant alerts that smart infusion pumps present to end users. Through a consensus-driven process, ICPS aimed to identify best practices to implement at individual hospitals in order to establish specific action items for smart-pump drug library optimization. A work group of pharmacists, nurses, and industrial engineers met to evaluate variability within and lack of scrutiny of smart-pump drug libraries. The work group used Lean Six Sigma methodologies to generate a list of key needs and barriers to be addressed in process standardization. The group reviewed targets for smart-pump drug library optimization, including dosing limits, types of alerts reviewed, policies, and safety best practices. The work group also analyzed existing processes at each site to develop a final consensus statement outlining a model process for reviewing alerts and managing smart-pump data. Analysis of the total number of alerts per device across ICPS-affiliated health systems over a 4-year period indicated a 50% decrease (from 7.2 to 3.6 alerts per device per month) after implementation of the model by ICPS member organizations. Through implementation of a standardized, consensus-driven process for smart-pump drug library optimization, ICPS member health systems reduced clinically insignificant smart-pump alerts. Copyright © 2018 by the American Society of Health-System Pharmacists, Inc. All rights reserved.

Teaching Outside the Box: ARL Librarians' Integration of the "One- Box" into Student Instruction

ERIC Educational Resources Information Center

Kulp, Christina; McCain, Cheryl; Scrivener, Laurie

2014-01-01

This article reports the results of a survey that targeted reference and instruction librarians who work at libraries that are members of the Asso- ciation of Research Libraries (ARL). Respondents were asked to indicate whether or not they teach students to use the one-box tool, and why or why not. Based on the responses of the 352 librarians who…

Many Libraries Have Gone to Federated Searching to Win Users Back from Google. Is It Working?

ERIC Educational Resources Information Center

King, Douglas

2008-01-01

In the last issue, this journal asked a question on many librarians' minds, and it was pleased with the depth and variety of responses. As suggested by this journal editorial board member Oliver Pesch, readers were asked, "Many libraries have gone to federated searching to win users back from Google. Is it working?" Respondents approached the…

Library Services and Construction Act Amendments of 1990. Conference Report (To Accompany H.R. 2742). House of Representatives, 101st Congress, 2nd Session.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC.

This conference report on the Library Services and Construction Act Amendments of 1990 includes the text of a substitute amendment agreed to by a committee of House of Representatives and Senate members. Amendments are presented for the following sections of the act: (1) Short Title; References; (2) Definitions; (3) Authorization of…

Union-Active School Librarians and School Library Advocacy: A Modified Case Study of the British Columbia Teacher-Librarians' Association and the British Columbia Teachers' Federation

ERIC Educational Resources Information Center

Ewbank, Ann Dutton

2015-01-01

This modified case study examines how the members of the British Columbia Teacher-Librarians' Association (BCTLA), a Provincial Specialist Association (PSA) of the British Columbia Teachers' Federation (BCTF), work together to advocate for strong school library programs headed by a credentialed school librarian. Since 2002, despite nullification…

Interior Dialogues: Library Design Speaks Volumes to Users.

ERIC Educational Resources Information Center

Kniffel, Leonard

1992-01-01

Photo essay illustrates library interiors of 20 newly built or renovated libraries ranging from renovated Carnegies to multimillion dollar university pantheons. Facilities represent academic libraries, public libraries (including children's and young adult's sections), a history library, a medical library, and a corporate library. Names and…

Interior Design Factors in Library Facilities.

ERIC Educational Resources Information Center

Jackson, Patricia Ann

When planning the interior of a library facility, the planning team of librarian, library consultant, architect, and interior design consultant must focus attention on the basic principles of interior design and the psychological needs of the user. Colors for an interior should be selected with careful regard to space, light, and emotional and…

2 in 1: Designing a Combined Library That Works for Everybody.

ERIC Educational Resources Information Center

Olson, Renee

1996-01-01

Discusses the design of combined school/public libraries and includes the views of three high school librarians and two elementary school librarians who helped create combined libraries. Topics include physical design issues, including entrances, lighting, and location; funding; cost benefits; contracts; signage; and parking. (LRW)

Second-generation DNA-templated macrocycle libraries for the discovery of bioactive small molecules.

PubMed

Usanov, Dmitry L; Chan, Alix I; Maianti, Juan Pablo; Liu, David R

2018-07-01

DNA-encoded libraries have emerged as a widely used resource for the discovery of bioactive small molecules, and offer substantial advantages compared with conventional small-molecule libraries. Here, we have developed and streamlined multiple fundamental aspects of DNA-encoded and DNA-templated library synthesis methodology, including computational identification and experimental validation of a 20 × 20 × 20 × 80 set of orthogonal codons, chemical and computational tools for enhancing the structural diversity and drug-likeness of library members, a highly efficient polymerase-mediated template library assembly strategy, and library isolation and purification methods. We have integrated these improved methods to produce a second-generation DNA-templated library of 256,000 small-molecule macrocycles with improved drug-like physical properties. In vitro selection of this library for insulin-degrading enzyme affinity resulted in novel insulin-degrading enzyme inhibitors, including one of unusual potency and novel macrocycle stereochemistry (IC 50  = 40 nM). Collectively, these developments enable DNA-templated small-molecule libraries to serve as more powerful, accessible, streamlined and cost-effective tools for bioactive small-molecule discovery.

Designing Search: Effective Search Interfaces for Academic Library Web Sites

ERIC Educational Resources Information Center

Teague-Rector, Susan; Ghaphery, Jimmy

2008-01-01

Academic libraries customize, support, and provide access to myriad information systems, each with complex graphical user interfaces. The number of possible information entry points on an academic library Web site is both daunting to the end-user and consistently challenging to library Web site designers. Faced with the challenges inherent in…

Designing Mobile Technology to Enhance Library Space Use: Findings from an Undergraduate Student Competition

ERIC Educational Resources Information Center

Ward, David; Hahn, Jim; Mestre, Lori S.

2015-01-01

To explore how libraries might integrate student perspectives and needs into their mobile development workflow, one large academic research library developed a fun, collaborative design methodology in order to stimulate student creativity. As part of a national IMLS (Institute for Museums and Library Services) grant, "The Student/Library…

Smart Libraries: Integrating Communications Channels and Information Sources.

ERIC Educational Resources Information Center

Webb, T. D.; Jensen, E. A.

Noting that the changing nature of information delivery has established immediacy as the new basis for modern library service, this paper describes the new facilities design and floor plan for the library of Kapiolani Community College of the University of Hawaii. The new library was carefully designed so that students can move progressively from…

Design of focused and restrained subsets from extremely large virtual libraries.

PubMed

Jamois, Eric A; Lin, Chien T; Waldman, Marvin

2003-11-01

With the current and ever-growing offering of reagents along with the vast palette of organic reactions, virtual libraries accessible to combinatorial chemists can reach sizes of billions of compounds or more. Extracting practical size subsets for experimentation has remained an essential step in the design of combinatorial libraries. A typical approach to computational library design involves enumeration of structures and properties for the entire virtual library, which may be unpractical for such large libraries. This study describes a new approach termed as on the fly optimization (OTFO) where descriptors are computed as needed within the subset optimization cycle and without intermediate enumeration of structures. Results reported herein highlight the advantages of coupling an ultra-fast descriptor calculation engine to subset optimization capabilities. We also show that enumeration of properties for the entire virtual library may not only be unpractical but also wasteful. Successful design of focused and restrained subsets can be achieved while sampling only a small fraction of the virtual library. We also investigate the stability of the method and compare results obtained from simulated annealing (SA) and genetic algorithms (GA).

Accuracy of telephone reference service in health sciences libraries.

PubMed Central

Paskoff, B M

1991-01-01

Six factual queries were unobtrusively telephoned to fifty-one U.S. academic health sciences and hospital libraries. The majority of the queries (63.4%) were answered accurately. Referrals to another library or information source were made for 25.2% of the queries. Eleven answers (3.6%) were inaccurate, and no answer was provided for 7.8% of the queries. There was a correlation between the number of accurate answers provided and the presence of at least one staff member with a master's degree in library and information science. The correlation between employing a librarian certified by the Medical Library Association (MLA) and providing accurate answers was significant. The majority of referrals were to specific sources. If these "helpful referrals" are counted with accurate answers as correct responses, they total 76.8% of the answers. In a follow-up survey, five libraries stated that they did not provide accurate answers because they did not own an appropriate source. Staff-related problems were given as reasons for other than accurate answers by two of the libraries, while eight indicated that library policy prevented them from providing answers to the public. PMID:2039904

SLAS Library Telescope Program (Abstract)

NASA Astrophysics Data System (ADS)

Small, J. S.

2016-12-01

(Abstract only) In the fall of 2014, I submitted to the members of the St. Louis Astronomical Society to take the $1,000 profit we had from a convention we had hosted and use it to purchase three telescopes to modify for a Library Telescope program that was invented by Mark Stowbridge and promoted by the New Hampshire Astronomical Society. I had met Mark at NEAF in 2012 when he was walking the floor demonstrating the telescope. We held meetings with three libraries, the St. Louis County Library system, the St. Louis Public Library system and an independent library in Kirkwood, Missouri. The response was overwhelming! SLCL responded with a request for ten telescopes and SLPL asked for five. We did our first build in October, 2014 and placed a total of eighteen telescopes. Since that time, SLAS has placed a total of eighty-eight telescopes in library systems around the St. Louis Metro area, expanding into neighboring counties and across the river in Illinois. In this talk, I will discuss how to approach this project and put it in place in your libraries!

76 FR 60816 - Board of Visitors, United States Military Academy (USMA)

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-30

.... Location: Jefferson Hall Library, Haig Room. West Point, NY. 5. Purpose of the Meeting: This is the 2011... availability of space, this meeting is open to the public. Seating is on a first-come basis. 8. Committee's... provide time for member consideration. By rule, no member of the public attending open meetings will be...

ALA Salary Survey: Personal Members

ERIC Educational Resources Information Center

American Libraries, 1971

1971-01-01

A survey of the members of the American Library Association revealed that the principal salary determinants are academic degree, type of employer and sex. The obvious differences in the earnings of men and women is not only found in the early experience years but any narrowing which does take place in the wage gap seems to take place at the…

Principles for Assessing Student Engagement in the First Year of College

ERIC Educational Resources Information Center

Hayek, John; Kuh, George

2004-01-01

While most institutions know how many of their faculty members have terminal degrees and the number of books in the library, too few have reliable information about the frequency with which first-year students discuss ideas with faculty members outside class, how much time they spend on academic activities, or how often they interact with students…

Probing Chemical Space with Alkaloid-Inspired Libraries

PubMed Central

McLeod, Michael C.; Singh, Gurpreet; Plampin, James N.; Rane, Digamber; Wang, Jenna L.; Day, Victor W.; Aubé, Jeffrey

2014-01-01

Screening of small molecule libraries is an important aspect of probe and drug discovery science. Numerous authors have suggested that bioactive natural products are attractive starting points for such libraries, due to their structural complexity and sp3-rich character. Here, we describe the construction of a screening library based on representative members of four families of biologically active alkaloids (Stemonaceae, the structurally related cyclindricine and lepadiformine families, lupin, and Amaryllidaceae). In each case, scaffolds were based on structures of the naturally occurring compounds or a close derivative. Scaffold preparation was pursued following the development of appropriate enabling chemical methods. Diversification provided 686 new compounds suitable for screening. The libraries thus prepared had structural characteristics, including sp3 content, comparable to a basis set of representative natural products and were highly rule-of-five compliant. PMID:24451589

Rational Diversification of a Promoter Providing Fine-Tuned Expression and Orthogonal Regulation for Synthetic Biology

PubMed Central

Blount, Benjamin A.; Weenink, Tim; Vasylechko, Serge; Ellis, Tom

2012-01-01

Yeast is an ideal organism for the development and application of synthetic biology, yet there remain relatively few well-characterised biological parts suitable for precise engineering of this chassis. In order to address this current need, we present here a strategy that takes a single biological part, a promoter, and re-engineers it to produce a fine-graded output range promoter library and new regulated promoters desirable for orthogonal synthetic biology applications. A highly constitutive Saccharomyces cerevisiae promoter, PFY1p, was identified by bioinformatic approaches, characterised in vivo and diversified at its core sequence to create a 36-member promoter library. TetR regulation was introduced into PFY1p to create a synthetic inducible promoter (iPFY1p) that functions in an inverter device. Orthogonal and scalable regulation of synthetic promoters was then demonstrated for the first time using customisable Transcription Activator-Like Effectors (TALEs) modified and designed to act as orthogonal repressors for specific PFY1-based promoters. The ability to diversify a promoter at its core sequences and then independently target Transcription Activator-Like Orthogonal Repressors (TALORs) to virtually any of these sequences shows great promise toward the design and construction of future synthetic gene networks that encode complex “multi-wire” logic functions. PMID:22442681

Rational diversification of a promoter providing fine-tuned expression and orthogonal regulation for synthetic biology.

PubMed

Blount, Benjamin A; Weenink, Tim; Vasylechko, Serge; Ellis, Tom

2012-01-01

Yeast is an ideal organism for the development and application of synthetic biology, yet there remain relatively few well-characterised biological parts suitable for precise engineering of this chassis. In order to address this current need, we present here a strategy that takes a single biological part, a promoter, and re-engineers it to produce a fine-graded output range promoter library and new regulated promoters desirable for orthogonal synthetic biology applications. A highly constitutive Saccharomyces cerevisiae promoter, PFY1p, was identified by bioinformatic approaches, characterised in vivo and diversified at its core sequence to create a 36-member promoter library. TetR regulation was introduced into PFY1p to create a synthetic inducible promoter (iPFY1p) that functions in an inverter device. Orthogonal and scalable regulation of synthetic promoters was then demonstrated for the first time using customisable Transcription Activator-Like Effectors (TALEs) modified and designed to act as orthogonal repressors for specific PFY1-based promoters. The ability to diversify a promoter at its core sequences and then independently target Transcription Activator-Like Orthogonal Repressors (TALORs) to virtually any of these sequences shows great promise toward the design and construction of future synthetic gene networks that encode complex "multi-wire" logic functions.

The Role of Virtual Reference in Library Web Site Design: A Qualitative Source for Usage Data

ERIC Educational Resources Information Center

Powers, Amanda Clay; Shedd, Julie; Hill, Clay

2011-01-01

Gathering qualitative information about usage behavior of library Web sites is a time-consuming process requiring the active participation of patron communities. Libraries that collect virtual reference transcripts, however, hold valuable data regarding how the library Web site is used that could benefit Web designers. An analysis of virtual…

Family History and the History of Families

ERIC Educational Resources Information Center

Selleck, R. J. W.

2004-01-01

The State Library of Victoria, which opened its doors in Melbourne in 1856, was designed and built in a confident and expansive decade. Even as war clouds gathered in 1913 the Library's confidence remained strong and it added a magnificent domed reading room, designed with the British Museum Library very much in mind. In the Library's genealogical…

Academic Libraries as High-Tech Gateways: A Guide to Design & Space Decisions. Second Edition.

ERIC Educational Resources Information Center

Bazillion, Richard J.; Braun, Connie L.

This book, based on research about libraries around the country, provides tools that can be used for planning and building an academic library space that streamlines access to information. It explains how to incorporate the latest innovations in academic library facility design; how to make the facility flexible for changing information technology…

Multicapillary Flow Reactor: Synthesis of 1,2,5-Thiadiazepane 1,1-Dioxide Library Utilizing One-Pot Elimination and Inter-/Intramolecular Double aza-Michael Addition Via Microwave-Assisted, Continuous-Flow Organic Synthesis (MACOS)

PubMed Central

Ullah, Farman; Zang, Qin; Javed, Salim; Zhou, Aihua; Knudtson, Christopher A.; Bi, Danse; Hanson, Paul R.; Organ, Michael G.

2013-01-01

A microwave-assisted, continuous-flow organic synthesis (MACOS) protocol for the synthesis of functionalized 1,2,5-thiadiazepane 1,1-dioxide library, utilizing a one-pot elimination and inter-/intramolecular double aza-Michael addition strategy is reported. The optimized protocol in MACOS was utilized for scale-out and further extended for library production using a multicapillary flow reactor. A 50-member library of 1,2,5-thiadiazepane 1,1-dioxides was prepared on a 100- to 300-mg scale with overall yields between 50 and 80% and over 90 % purity determined by proton nuclear magnetic resonance (1H-NMR) spectroscopy. PMID:24244871

Discovery of new antimalarial chemotypes through chemical methodology and library development.

PubMed

Brown, Lauren E; Chih-Chien Cheng, Ken; Wei, Wan-Guo; Yuan, Pingwei; Dai, Peng; Trilles, Richard; Ni, Feng; Yuan, Jing; MacArthur, Ryan; Guha, Rajarshi; Johnson, Ronald L; Su, Xin-zhuan; Dominguez, Melissa M; Snyder, John K; Beeler, Aaron B; Schaus, Scott E; Inglese, James; Porco, John A

2011-04-26

In an effort to expand the stereochemical and structural complexity of chemical libraries used in drug discovery, the Center for Chemical Methodology and Library Development at Boston University has established an infrastructure to translate methodologies accessing diverse chemotypes into arrayed libraries for biological evaluation. In a collaborative effort, the NIH Chemical Genomics Center determined IC(50)'s for Plasmodium falciparum viability for each of 2,070 members of the CMLD-BU compound collection using quantitative high-throughput screening across five parasite lines of distinct geographic origin. Three compound classes displaying either differential or comprehensive antimalarial activity across the lines were identified, and the nascent structure activity relationships (SAR) from this experiment used to initiate optimization of these chemotypes for further development.

CGNS Mid-Level Software Library and Users Guide

NASA Technical Reports Server (NTRS)

Poirier, Diane; Smith, Charles A. (Technical Monitor)

1998-01-01

The "CFD General Notation System" (CGNS) consists of a collection of conventions, and conforming software, for the storage and retrieval of Computational Fluid Dynamics (CFD) data. It facilitates the exchange of data between sites and applications, and helps stabilize the archiving of aerodynamic data. This effort was initiated in order to streamline the procedures in exchanging data and software between NASA and its customers, but the goal is to develop CGNS into a National Standard for the exchange of aerodynamic data. The CGNS development team is comprised of members from Boeing Commercial Airplane Group, NASA-Ames, NASA-Langley, NASA-Lewis, McDonnell-Douglas Corporation (now Boeing-St. Louis), Air Force-Wright Lab., and ICEM-CFD Engineering. The elements of CGNS address all activities associated with the storage of data on external media and its movement to and from application programs. These elements include: - The Advanced Data Format (ADF) Database manager, consisting of both a file format specification and its I/O software, which handles the actual reading and writing of data from and to external storage media; - The Standard Interface Data Structures (SIDS), which specify the intellectual content of CFD data and the conventions governing naming and terminology; - The SIDS-to-ADF File Mapping conventions, which specify the exact location where the CFD data defined by the SIDS is to be stored within the ADF file(s); and - The CGNS Mid-level Library, which provides CFD-knowledgeable routines suitable for direct installation into application codes. The CGNS Mid-level Library was designed to ease the implementation of CGNS by providing developers with a collection of handy I/O functions. Since knowledge of the ADF core is not required to use this library, it will greatly facilitate the task of interfacing with CGNS. There are currently 48 user callable functions that comprise the Mid-level library and are described in the Users Guide. The library is written in C, but each function has a FORTRAN counterpart.

Comparison of bioluminescent kinase assays using substrate depletion and product formation.

PubMed

Tanega, Cordelle; Shen, Min; Mott, Bryan T; Thomas, Craig J; MacArthur, Ryan; Inglese, James; Auld, Douglas S

2009-12-01

Assays for ATPases have been enabled for high-throughput screening (HTS) by employing firefly luciferase to detect the remaining ATP in the assay. However, for any enzyme assay, measurement of product formation is a more sensitive assay design. Recently, technologies that allow detection of the ADP product from ATPase reactions have been described using fluorescent methods of detection. We describe here the characterization of a bioluminescent assay that employs firefly luciferase in a coupled-enzyme assay format to enable detection of ADP levels from ATPase assays (ADP-Glo, Promega Corp.). We determined the performance of the ADP-Glo assay in 1,536-well microtiter plates using the protein kinase Clk4 and a 1,352 member kinase focused combinatorial library. The ADP-Glo assay was compared to the Clk4 assay performed using a bioluminescence ATP-depletion format (Kinase-Glo, Promega Corp). We performed this analysis using quantitative HTS (qHTS) where we determined potency values for all library members and identified approximately 300 compounds with potencies ranging from as low as 50 nM to >10 microM, yielding a robust dataset for the comparison. Both assay formats showed high performance (Z'-factors approximately 0.9) and showed a similar potency distribution for the actives. We conclude that the bioluminescence ADP detection assay system is a viable generic alternative to the widely used ATP-depletion assay for ATPases and discuss the advantages and disadvantages of both approaches.

Selection of Sphingomonadaceae at the base of Laccaria proxima and Russula exalbicans fruiting bodies.

PubMed

Boersma, F G Hidde; Warmink, Jan A; Andreote, Fernando A; van Elsas, Jan Dirk

2009-04-01

The dense hyphal network directly underneath the fruiting bodies of ectomycorrhizal fungi might exert strong influences on the bacterial community of soil. Such fruiting bodies might serve as hot spots for bacterial activity, for instance by providing nutrients and colonization sites in soil. Here, we assessed the putative selection of specific members of the Sphingomonadaceae family at the bases of the fruiting bodies of the ectomycorrhizal fungi Laccaria proxima and Russula exalbicans in comparison to the adjacent bulk soil. To do so, we used a previously designed Sphingomonadaceae-specific PCR-denaturing gradient gel electrophoresis (DGGE) system and complemented this with analyses of sequences from a Sphingomonadaceae-specific clone library. The analyses showed clear selective effects of the fruiting bodies of both fungi on the Sphingomonadaceae community structures. The effect was especially prevalent with R. exalbicans. Strikingly, similar fungi sampled approximately 100 m apart showed similar DGGE patterns, while corresponding bulk soil-derived patterns differed from each other. However, the mycospheres of L. proxima and R. exalbicans still revealed divergent community structures, indicating that different fungi select for different members of the Sphingomonadaceae family. Excision of specific bands from the DGGE patterns, as well as analyses of the clone libraries generated from both habitats, revealed fruiting body-specific Sphingomonadaceae types. It further showed that major groups from the mycospheres of R. exalbicans and L. proxima did not cluster with known bacteria from the database, indicating new groups within the family of Sphingomonadaceae present in these environments.

AUX: a scripting language for auditory signal processing and software packages for psychoacoustic experiments and education.

PubMed

Kwon, Bomjun J

2012-06-01

This article introduces AUX (AUditory syntaX), a scripting syntax specifically designed to describe auditory signals and processing, to the members of the behavioral research community. The syntax is based on descriptive function names and intuitive operators suitable for researchers and students without substantial training in programming, who wish to generate and examine sound signals using a written script. In this article, the essence of AUX is discussed and practical examples of AUX scripts specifying various signals are illustrated. Additionally, two accompanying Windows-based programs and development libraries are described. AUX Viewer is a program that generates, visualizes, and plays sounds specified in AUX. AUX Viewer can also be used for class demonstrations or presentations. Another program, Psycon, allows a wide range of sound signals to be used as stimuli in common psychophysical testing paradigms, such as the adaptive procedure, the method of constant stimuli, and the method of adjustment. AUX Library is also provided, so that researchers can develop their own programs utilizing AUX. The philosophical basis of AUX is to separate signal generation from the user interface needed for experiments. AUX scripts are portable and reusable; they can be shared by other researchers, regardless of differences in actual AUX-based programs, and reused for future experiments. In short, the use of AUX can be potentially beneficial to all members of the research community-both those with programming backgrounds and those without.

Planning and Designing Academic Library Learning Spaces: Expert Perspectives of Architects, Librarians, and Library Consultants. Project Information Literacy Research Report. The Practitioner Series

ERIC Educational Resources Information Center

Head, Alison J.

2016-01-01

This paper identifies approaches, challenges, and best practices related to planning and designing today's academic library learning spaces. As part of the Project Information Literacy (PIL) Practitioner Series, qualitative data is presented from 49 interviews conducted with a sample of academic librarians, architects, and library consultants.…

Library Architecture: The Cleveland Experience.

ERIC Educational Resources Information Center

Gaines, Ervin; And Others

1982-01-01

Discusses the importance of a well-designed library building as an important factor in creating social benefits and positive political responses in the community. The creation and implementation of design criteria for the Cleveland Public Library and the public response are described. (CHC)

Current issues in the design of academic health sciences libraries: findings from three recent facility projects*

PubMed Central

Nelson, Patricia P.

2003-01-01

Planning a new health sciences library at the beginning of the twenty-first century is a tremendous challenge. Technology has radically changed the way libraries function in an academic environment and the services they provide. Some individuals question whether the library as place will continue to exist as information becomes increasingly available electronically. To understand how libraries resolve programming and building design issues, visits were made to three academic health sciences libraries that have had significant renovation or completed new construction. The information gathered will be valuable for planning a new library for the University of Colorado Health Sciences Center and may assist other health sciences librarians as they plan future library buildings. PMID:12883559

Design and Synthesis of Biaryl DNA-Encoded Libraries.

PubMed

Ding, Yun; Franklin, G Joseph; DeLorey, Jennifer L; Centrella, Paolo A; Mataruse, Sibongile; Clark, Matthew A; Skinner, Steven R; Belyanskaya, Svetlana

2016-10-10

DNA-encoded library technology (ELT) is a powerful tool for the discovery of new small-molecule ligands to various protein targets. Here we report the design and synthesis of biaryl DNA-encoded libraries based on the scaffold of 5-formyl 3-iodobenzoic acid. Three reactions on DNA template, acylation, Suzuki-Miyaura coupling and reductive amination, were applied in the library synthesis. The three cycle library of 3.5 million diversity has delivered potent hits for phosphoinositide 3-kinase α (PI3Kα).

Bibliotherapy for mental health service users Part 2: a survey of psychiatric libraries in the UK.

PubMed

Fanner, Deborah; Urqhuart, Christine

2009-06-01

UK health policy advocates a patient-centred approach to patient care. Library services could serve the rehabilitation needs of mental health service users through bibliotherapy (the use of written, audio or e-learning materials to provide therapeutic support). Part 2 of this two-part paper assesses the views of psychiatric libraries in the UK on providing access to service users and possible services provided. An e-mail questionnaire survey of psychiatric library members of the psychiatric lending co-operative scheme (n = 100) obtained a response rate of 55%, mostly from libraries based in hospitals. At present, libraries funded by the health service provide minimal facilities for service users. Librarians are uncertain about the benefits and practicalities of providing access to service users. In order to implement change, information providers across the National Health Service (NHS) will need to work collaboratively to overcome attitudinal and institutional barriers, including the key issue of funding.

Public librarians as a resource for promoting health: results from the Health for Everyone in Libraries Project (HELP) librarian survey.

PubMed

Linnan, Laura A; Wildemuth, Barbara M; Gollop, Claudia; Hull, Peggy; Silbajoris, Christie; Monnig, Ruth

2004-04-01

Public libraries are located in all communities, and two thirds of adults visit one each year. Libraries give the public access to computers and the Internet, and librarians offer technical assistance for accessing information. The interests and training needs of public librarians for assisting the public in accessing health information have not been addressed. One public library/librarian in each North Carolina county was randomly selected to complete a written questionnaire to assess health-related information services and librarians' skills for providing these services. 84% of librarians (83/99) completed the questionnaire. Results indicate that librarians answer more than 10 health-related questions per week, feel moderately comfortable answering these questions, and are very interested in receiving additional training for addressing health-related questions. Creating public library/public health partnerships holds much promise for enhancing the ability of community members to access desired health information.

A Library of Optimization Algorithms for Organizational Design

DTIC Science & Technology

2005-01-01

N00014-98-1-0465 and #N00014-00-1-0101 A Library of Optimization Algorithms for Organizational Design Georgiy M. Levchuk Yuri N. Levchuk Jie Luo...E-mail: Krishna@engr.uconn.edu Abstract This paper presents a library of algorithms to solve a broad range of optimization problems arising in the...normative design of organizations to execute a specific mission. The use of specific optimization algorithms for different phases of the design process

Electron lithography STAR design guidelines. Part 1: The STAR user design manual

NASA Technical Reports Server (NTRS)

Trotter, J. D.; Newman, W.

1982-01-01

The STAR system developed by NASA enables any user with a logic diagram to design a semicustom digital MOS integrated circuit. The system is comprised of a library of standard logic cells and computer programs to place, route, and display designs implemented with cells from the library. Library cells of the CMOS metal gate and CMOS silicon gate technologies were simulated using SPICE, and the results are shown and compared.

Include Your Patrons in Web Design. Computers in Small Libraries

ERIC Educational Resources Information Center

Roberts, Gary

2005-01-01

Successful Web publishing requires not only technical skills but also a refined sense of taste, a good understanding of design, and strong writing abilities. When designing a library Web page, a person must possess all of these talents and be able to market to a broad spectrum of patrons. As a result, library sites vary widely in their style and…

Design of combinatorial libraries for the exploration of virtual hits from fragment space searches with LoFT.

PubMed

Lessel, Uta; Wellenzohn, Bernd; Fischer, J Robert; Rarey, Matthias

2012-02-27

A case study is presented illustrating the design of a focused CDK2 library. The scaffold of the library was detected by a feature trees search in a fragment space based on reactions from combinatorial chemistry. For the design the software LoFT (Library optimizer using Feature Trees) was used. The special feature called FTMatch was applied to restrict the parts of the queries where the reagents are permitted to match. This way a 3D scoring function could be simulated. Results were compared with alternative designs by GOLD docking and ROCS 3D alignments.

Studying a Drug-like, RNA-Focused Small Molecule Library Identifies Compounds That Inhibit RNA Toxicity in Myotonic Dystrophy.

PubMed

Rzuczek, Suzanne G; Southern, Mark R; Disney, Matthew D

2015-12-18

There are many RNA targets in the transcriptome to which small molecule chemical probes and lead therapeutics are desired. However, identifying compounds that bind and modulate RNA function in cellulo is difficult. Although rational design approaches have been developed, they are still in their infancies and leave many RNAs "undruggable". In an effort to develop a small molecule library that is biased for binding RNA, we computationally identified "drug-like" compounds from screening collections that have favorable properties for binding RNA and for suitability as lead drugs. As proof-of-concept, this collection was screened for binding to and modulating the cellular dysfunction of the expanded repeating RNA (r(CUG)(exp)) that causes myotonic dystrophy type 1. Hit compounds bind the target in cellulo, as determined by the target identification approach Competitive Chemical Cross-Linking and Isolation by Pull-down (C-ChemCLIP), and selectively improve several disease-associated defects. The best compounds identified from our 320-member library are more potent in cellulo than compounds identified by high-throughput screening (HTS) campaigns against this RNA. Furthermore, the compound collection has a higher hit rate (9% compared to 0.01-3%), and the bioactive compounds identified are not charged; thus, RNA can be "drugged" with compounds that have favorable pharmacological properties. Finally, this RNA-focused small molecule library may serve as a useful starting point to identify lead "drug-like" chemical probes that affect the biological (dys)function of other RNA targets by direct target engagement.

Variable epitope libraries: new vaccine immunogens capable of inducing broad human immunodeficiency virus type 1-neutralizing antibody response.

PubMed

Charles-Niño, Claudia; Pedroza-Roldan, Cesar; Viveros, Monica; Gevorkian, Goar; Manoutcharian, Karen

2011-07-18

The extreme antigenic variability of human immunodeficiency virus (HIV) leads to immune escape of the virus, representing a major challenge in the design of effective vaccine. We have developed a novel concept for immunogen construction based on introduction of massive mutations within the epitopes targeting antigenically variable pathogens and diseases. Previously, we showed that these immunogens carrying large combinatorial libraries of mutated epitope variants, termed as variable epitope libraries (VELs), induce potent, broad and long lasting CD8+IFN-γ+ T-cell response. Moreover, we demonstrated that these T cells recognize more than 50% of heavily mutated variants (5 out of 10 amino acid positions were mutated in each epitope variant) of HIV-1 gp120 V3 loop-derived cytotoxic T lymphocyte epitope (RGPGRAFVTI) in mice. The constructed VELs had complexities of 10000 and 12500 individual members, generated as plasmid DNA or as M13 phage display combinatorial libraries, respectively, and with structural composition RGPGXAXXXX or XGXGXAXVXI, where X is any of 20 natural amino acids. Here, we demonstrated that sera from mice immunized with these VELs are capable of neutralizing 5 out of 10 viral isolates from Tier 2 reference panel of subtype B envelope clones, including HIV-1 isolates which are known to be resistant to neutralization by several potent monoclonal antibodies, described previously. These data indicate the feasibility of the application of immunogens based on VEL concept as an alternative approach for the development of molecular vaccines against antigenically variable pathogens. Copyright © 2011 Elsevier Ltd. All rights reserved.

Support and Dissemination of Teacher-Authored Lesson Plans: a Digital Library for Earth System Education (DLESE) and Geological Society of America (GSA) Collaboration

NASA Astrophysics Data System (ADS)

Devaul, H.; Pandya, R. E.; McLelland, C. V.

2003-12-01

The Digital Library for Earth System Education (www.dlese.org) and the Geological Society of America (www.geosociety.org) are working together to publish and disseminate teacher-authored Earth science lesson plans. DLESE is a community-based effort involving teachers, students, and scientists working together to create a library of educational resources and services to support Earth system science education. DLESE offers free access to electronic resources including lesson plans, maps, images, data sets, visualizations, and assessment activities. A number of thematic collections have recently been accessioned, which has substantially increased library holdings. Working in concert with GSA, a non-profit organization dedicated to the advancement of the geosciences, small-scale resource creators such as classroom teachers without access to a web server can also share educational resources of their own design. Following a two-step process, lesson plans are submitted to the GSA website, reviewed and posted to the K-12 resource area: http://www.geosociety.org/educate/resources.htm. These resources are also submitted to the DLESE Community Collection using a simple cataloging tool. In this way resources are available to other teachers via the GSA website as well as via the DLESE collection. GSA provides a template for lesson plan developers which assists in providing the necessary information to help users find and understand the intent of the activity when searching in DLESE. This initial effort can serve as a prototype for important services allowing individual community members to contribute their work to DLESE with little technical overhead.

Director's report.

PubMed

Pathak, K B

1993-07-01

The director's report for the International Institute for Population Sciences in Bombay, India, provides descriptions of the Institute's teaching programs, research, publications, seminars, library collection, visitors, faculty and staff, and special events. The teaching programs include regular instruction in one-year diploma courses in population studies and a masters and a masters in philosophy in population studies; a diploma is also available in health education. Student represent a variety of countries for the diploma programs, while the other certificate programs draw on the national population. A listing is provided of those receiving certificates. Research programs are listed by whether the program was completed during 1992-93 or earlier or is a new project. The Institute conducts a National Family Welfare Survey among 23 states. This household survey is directed to women and supplies village level data. The Institute publishes a quarterly newsletter about ongoing activities and a biennial compendium of research findings. The Institute observes World Population Day and organized the 10th Annual Convention on Medical Statistics and other conferences. The Institute held the first meeting of the National Council of Population Research on September 21, 1992, and the designated subcommittee members met on November 14, 1992. The library recently added 1117 volumes, which contributed to the total library collection of 55,539 volumes, including 8000 bound periodicals and 12,615 reprints. Several high government officials visited the Institute in 1992. Other visitors came from the US, Bangladesh, and the UN. The Institute is comprised of six academic departments with computer and library resources. Staff were involved a few overseas tours of study. Founders day is celebrated as a cultural event.

Defining the RNA Internal Loops Preferred by Benzimidazole Derivatives via Two-Dimensional Combinatorial Screening and Computational Analysis

PubMed Central

Velagapudi, Sai Pradeep; Seedhouse, Steven J.; French, Jonathan

2011-01-01

RNA is an important therapeutic target, however, RNA targets are generally underexploited due to a lack of understanding of the small molecules that bind RNA and the RNA motifs that bind small molecules. Herein, we describe the identification of the RNA internal loops derived from a 4096-member 3×3 nucleotide loop library that are the most specific and highest affinity binders to a series of four designer, drug-like benzimidazoles. These studies establish a potentially general protocol to define the highest affinity and most specific RNA motif targets for heterocyclic small molecules. Such information could be used to target functionally important RNAs in genomic sequence. PMID:21604752

Services of the Central Education Library of the Peel Board of Education Serving Graduates at Brock University and the Extension Campus of the Ontario Institute of Studies in Education: A Survey.

ERIC Educational Resources Information Center

Wilkins, Catherine E.

1992-01-01

Assesses the resources and services of the Central Education Library of the Peel Board of Education through a survey of the views and opinions of its two primary user groups: (1) members of the Peel Board of Education, and (2) faculty in graduate education programs in Ontario. (19 references) (LAE)

Engineering M13 for phage display.

PubMed

Sidhu, S S

2001-09-01

Phage display is achieved by fusing polypeptide libraries to phage coat proteins. The resulting phage particles display the polypeptides on their surfaces and they also contain the encoding DNA. Library members with particular functions can be isolated with simple selections and polypeptide sequences can be decoded from the encapsulated DNA. The technology's success depends on the efficiency with which polypeptides can be displayed on the phage surface, and significant progress has been made in engineering M13 bacteriophage coat proteins as improved phage display platforms. Functional display has been achieved with all five M13 coat proteins, with both N- and C-terminal fusions. Also, coat protein mutants have been designed and selected to improve the efficiency of heterologous protein display, and in the extreme case, completely artificial coat proteins have been evolved specifically as display platforms. These studies demonstrate that the M13 phage coat is extremely malleable, and this property can be used to engineer the phage particle specifically for phage display. These improvements expand the utility of phage display as a powerful tool in modern biotechnology.

Assessment of vaccination-related information for consumers available on Facebook.

PubMed

Buchanan, Rachel; Beckett, Robert D

2014-09-01

To assess the magnitude, interest, purpose and validity of vaccination-related information on Facebook and to determine whether information varies by site viewpoint. The 10 largest vaccination-focused Facebook pages, groups and places in each category were identified and classified by viewpoint (i.e. anti-, pro-, neutral) and purpose. Number of members, posts per week, likes, comments and shares per post were recorded. Posts were assessed for concordance with CDC and FDA recommendations. Of 30 sites, 43% (n = 13) were anti-vaccination, 7% (n = 2) neutral and 50% (n = 15) pro-vaccination. Most sites were most popular with American users. Median members were similar between anti-vaccination (2703 members, range 337-33 631 members) and pro-vaccination sites (2142 members, range 456-61,565 members, P = 0.262); however, anti-vaccination sites accumulated more posts per week by authors (median 15 vs. 3, P = 0.031) and members (median 33 vs. 1, P < 0.001). Pro-vaccination sites more commonly had commercial purpose (53% [n = 8] vs. 8% [n = 1], P = 0.02). Anti-vaccination sites more commonly gave medical advice (54% [n = 7] vs. 0%, P = 0.004). Overall, 48% (n = 22) of author posts were concordant with regulatory recommendations; concordance was more common on pro-vaccination sites (78% [n = 21] vs. 5% [n = 1], P = 0.0002). Vaccination-related information is prevalent on Facebook regardless of viewpoint; however, anti-vaccination information generates more interest. Anti-vaccination sites were likely to provide medical advice and disagree with regulatory bodies. © 2014 The authors. Health Information and Libraries Journal © 2014 Health Libraries Group.

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

The Library Services Alliance is a unique multi-type library consortium committed to resource sharing. As a voluntary association of university and governmental laboratory libraries supporting scientific research, the Alliance has become a leader in New Mexico in using cooperative ventures to cost-effectively expand resources supporting their scientific and technical communities. During 1994, the alliance continued to expand on their strategic planning foundation to enhance access to research information for the scientific and technical communities. Significant progress was made in facilitating easy access to the on-line catalogs of member libraries via connections through the Internet. Access to Alliance resources is nowmore » available via the World Wide Web and Gopher, as well as links to other databases and electronic information. This report highlights the accomplishments of the Alliance during calendar year 1994.« less

Multi-registration of software library resources

DOEpatents

Archer, Charles J [Rochester, MN; Blocksome, Michael A [Rochester, MN; Ratterman, Joseph D [Rochester, MN; Smith, Brian E [Rochester, MN

2011-04-05

Data communications, including issuing, by an application program to a high level data communications library, a request for initialization of a data communications service; issuing to a low level data communications library a request for registration of data communications functions; registering the data communications functions, including instantiating a factory object for each of the one or more data communications functions; issuing by the application program an instruction to execute a designated data communications function; issuing, to the low level data communications library, an instruction to execute the designated data communications function, including passing to the low level data communications library a call parameter that identifies a factory object; creating with the identified factory object the data communications object that implements the data communications function according to the protocol; and executing by the low level data communications library the designated data communications function.

Design Dimensions Enabling Divergent Behaviour across Physical, Digital, and Social Library Interfaces

NASA Astrophysics Data System (ADS)

Björneborn, Lennart

What design dimensions across physical, digital, and social library interfaces may enable and trigger users to find more information resources than planned or known in advance? The paper outlines a conceptual framework with libraries as integrative interfaces across physical, digital, and social affordances and users that mix convergent (goal-directed) and divergent (exploratory) information behaviour. Ten design dimensions that enable and trigger divergent behaviour are outlined. Implications for persuasive design are discussed.

E-Global Library: The Academic Campus Library Meets the Internet.

ERIC Educational Resources Information Center

Heilig, Jean M.

2001-01-01

Describes e-global library, the first Internet-based virtual library designed for online students at Jones International University and that has grown into a separately licensable product. Highlights include marketing to other academic libraries, both online and traditional; fees; the e-global library model; collection development policies;…

A Model for Designing Library Instruction for Distance Learning

ERIC Educational Resources Information Center

Rand, Angela Doucet

2013-01-01

Providing library instruction in distance learning environments presents a unique set of challenges for instructional librarians. Innovations in computer-mediated communication and advances in cognitive science research provide the opportunity for designing library instruction that meets a variety of student information seeking needs. Using a…

Defining Collections in Distributed Digital Libraries.

ERIC Educational Resources Information Center

Logoze, Carl; Fielding, David

1998-01-01

Describes the design for a digital collection service, an independent mechanism for introducing structure into a distributed space, research by Cornell Digital Library Research Group (CDLRG). Summarizes the component-based digital library architecture that is the context for the design. Describes a collection abstraction that is appropriate for…

Library Design Analysis Using Post-Occupancy Evaluation Methods.

ERIC Educational Resources Information Center

James, Dennis C.; Stewart, Sharon L.

1995-01-01

Presents findings of a user-based study of the interior of Rodger's Science and Engineering Library at the University of Alabama. Compared facility evaluations from faculty, library staff, and graduate and undergraduate students. Features evaluated include: acoustics, aesthetics, book stacks, design, finishes/materials, furniture, lighting,…

A DNA Barcode Library for North American Pyraustinae (Lepidoptera: Pyraloidea: Crambidae).

PubMed

Yang, Zhaofu; Landry, Jean-François; Hebert, Paul D N

2016-01-01

Although members of the crambid subfamily Pyraustinae are frequently important crop pests, their identification is often difficult because many species lack conspicuous diagnostic morphological characters. DNA barcoding employs sequence diversity in a short standardized gene region to facilitate specimen identifications and species discovery. This study provides a DNA barcode reference library for North American pyraustines based upon the analysis of 1589 sequences recovered from 137 nominal species, 87% of the fauna. Data from 125 species were barcode compliant (>500bp, <1% n), and 99 of these taxa formed a distinct cluster that was assigned to a single BIN. The other 26 species were assigned to 56 BINs, reflecting frequent cases of deep intraspecific sequence divergence and a few instances of barcode sharing, creating a total of 155 BINs. Two systems for OTU designation, ABGD and BIN, were examined to check the correspondence between current taxonomy and sequence clusters. The BIN system performed better than ABGD in delimiting closely related species, while OTU counts with ABGD were influenced by the value employed for relative gap width. Different species with low or no interspecific divergence may represent cases of unrecognized synonymy, whereas those with high intraspecific divergence require further taxonomic scrutiny as they may involve cryptic diversity. The barcode library developed in this study will also help to advance understanding of relationships among species of Pyraustinae.

A University-Wide Collaborative Effort to Designing a Makerspace at an Academic Health Sciences Library.

PubMed

Herron, Jennifer; Kaneshiro, Kellie

2017-01-01

This article describes the planning and development of a 3D printing makerspace at an academic health sciences library. At the start of 2015, a new library Technology Team was formed consisting of a team leader, an emerging technologies librarian, and a library systems analyst. One of the critical steps in the development of the proposal and with the planning of this project was collaborating and partnering with different departments and units outside the library. These connections helped shape the design of the makerspace.

10 Tips for Getting Grants to Keep Your Library Afloat

ERIC Educational Resources Information Center

McCune, Bonnie

2007-01-01

In this article, the author, taking the view of the foundation or the grant giver, shares the basic steps on how funders assess requests for grants. Each of these steps may be waived if a key member of the selection process, such as a board member, has a personal interest in the application. The following are 10 tips from the funders' point of…

Use of focus groups in a library's strategic planning process.

PubMed

Higa-Moore, Mori Lou; Bunnett, Brian; Mayo, Helen G; Olney, Cynthia A

2002-01-01

The use of focus groups to determine patron satisfaction with library resources and services is extensive and well established. This article demonstrates how focus groups can also be used to help shape the future direction of a library as part of the strategic planning process. By responding to questions about their long-term library and information needs, focus group participants at the University of Texas Southwestern Medical Center at Dallas Library contributed an abundance of qualitative patron data that was previously lacking from this process. The selection and recruitment of these patrons is discussed along with the line of questioning used in the various focus group sessions. Of special interest is the way the authors utilized these sessions to mobilize and involve the staff in creating the library's strategic plan. This was accomplished not only by having staff members participate in one of the sessions but also by sharing the project's major findings with them and instructing them in how these findings related to the library's future. The authors' experience demonstrates that focus groups are an effective strategic planning tool for libraries and emphasizes the need to share information broadly, if active involvement of the staff is desired in both the development and implementation of the library's strategic plan.

Use of focus groups in a library's strategic planning process

PubMed Central

Higa-Moore, Mori Lou; Bunnett, Brian; Mayo, Helen G.; Olney, Cynthia A.

2002-01-01

The use of focus groups to determine patron satisfaction with library resources and services is extensive and well established. This article demonstrates how focus groups can also be used to help shape the future direction of a library as part of the strategic planning process. By responding to questions about their long-term library and information needs, focus group participants at the University of Texas Southwestern Medical Center at Dallas Library contributed an abundance of qualitative patron data that was previously lacking from this process. The selection and recruitment of these patrons is discussed along with the line of questioning used in the various focus group sessions. Of special interest is the way the authors utilized these sessions to mobilize and involve the staff in creating the library's strategic plan. This was accomplished not only by having staff members participate in one of the sessions but also by sharing the project's major findings with them and instructing them in how these findings related to the library's future. The authors' experience demonstrates that focus groups are an effective strategic planning tool for libraries and emphasizes the need to share information broadly, if active involvement of the staff is desired in both the development and implementation of the library's strategic plan. PMID:11838465

PD5: a general purpose library for primer design software.

PubMed

Riley, Michael C; Aubrey, Wayne; Young, Michael; Clare, Amanda

2013-01-01

Complex PCR applications for large genome-scale projects require fast, reliable and often highly sophisticated primer design software applications. Presently, such applications use pipelining methods to utilise many third party applications and this involves file parsing, interfacing and data conversion, which is slow and prone to error. A fully integrated suite of software tools for primer design would considerably improve the development time, the processing speed, and the reliability of bespoke primer design software applications. The PD5 software library is an open-source collection of classes and utilities, providing a complete collection of software building blocks for primer design and analysis. It is written in object-oriented C(++) with an emphasis on classes suitable for efficient and rapid development of bespoke primer design programs. The modular design of the software library simplifies the development of specific applications and also integration with existing third party software where necessary. We demonstrate several applications created using this software library that have already proved to be effective, but we view the project as a dynamic environment for building primer design software and it is open for future development by the bioinformatics community. Therefore, the PD5 software library is published under the terms of the GNU General Public License, which guarantee access to source-code and allow redistribution and modification. The PD5 software library is downloadable from Google Code and the accompanying Wiki includes instructions and examples: http://code.google.com/p/primer-design.

Recent health sciences library building projects.

PubMed Central

Ludwig, L

1993-01-01

The Medical Library Association's third annual survey of recent health sciences library building projects identified fourteen libraries planning, expanding, or constructing new library facilities. Three of five new library buildings are freestanding structures where the library occupies all or a major portion of the space. The two other new facilities are for separately administered units where the library is a major tenant. Nine projects involve additions to or renovations of existing space. Six projects are in projected, predesign, or design stages or are awaiting funding approval. This paper describes four projects that illustrate technology's growing effect on librarians and libraries. They are designed to accommodate change, a plethora of electronic gear, and easy use of technology. Outwardly, they do not look much different than many other modern buildings. But, inside, the changes have been dramatic although they have evolved slowly as the building structure has been adapted to new conditions. Images PMID:8251970

The Microcomputer in the Library: VI. Implementation and Future Development.

ERIC Educational Resources Information Center

Leggate, Peter; Dyer, Hilary

1986-01-01

This sixth article in a series discusses planning for the installation and implementation of automated systems in the library, workstation design and location, scheduling of software implementation, security, data input, staff and reader training, job design, impact of automation on library procedures, evaluation of system performance, and future…

Perspective view, northeast. Billings Memorial Library was designed by H.H. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Perspective view, northeast. Billings Memorial Library was designed by H.H. Richardson in 1883-85 in his characteristic Romanesque Revival mode. Located on the University of Vermont campus, it is now a student center. - University of Vermont, Billings Memorial Library, 48 University Place, Burlington, Chittenden County, VT

A Library Based Apprenticeship in Psychology Research.

ERIC Educational Resources Information Center

Ross, Linda; Carter, Elizabeth W.

A collaboration to develop materials that will foster critical thinking and communication skills through library-based research is described and presented. Library activities were designed to promote the use of cognitive skills, such as analysis, synthesis, and evaluation. This was a pilot study designed to expose undergraduate students to one…

A Literature Review of Academic Library Web Page Studies

ERIC Educational Resources Information Center

Blummer, Barbara

2007-01-01

In the early 1990s, numerous academic libraries adopted the web as a communication tool with users. The literature on academic library websites includes research on both design and navigation. Early studies typically focused on design characteristics, since websites initially merely provided information on the services and collections available in…

Design for Change: How to Plan the School Library You Really Need.

ERIC Educational Resources Information Center

Lankford, Mary D.

1994-01-01

Examines issues that librarians need to address when remodeling or designing school libraries. Topics discussed include the librarian's role in decision making; cost considerations; evaluation of present services as well as future needs; the importance of communication; location; library technology; furniture; and the role of architects and…

Washington Public Libraries Online: Collaborating in Cyberspace.

ERIC Educational Resources Information Center

Wildin, Nancy

1997-01-01

Discussion of public libraries, the Internet, and the World Wide Web focuses on development of a Web site in Washington. Highlights include access to the Internet through online public access catalogs; partnerships between various types of libraries; hardware and software; HTML training; content design; graphics design; marketing; evaluation; and…

Designing Authentic Learning Tasks for Online Library Instruction

ERIC Educational Resources Information Center

Finch, Jannette L.; Jefferson, Renee N.

2013-01-01

This empirical study explores whether authentic tasks designed specifically for deliberately grouped students have an effect on student perception of teaching presence and student cognitive gains. In one library research class offered in an express session online, the instructor grouped students randomly. In a second online library research class,…

Personal Computing and Academic Library Design.

ERIC Educational Resources Information Center

Bazillion, Richard J.

1992-01-01

Notebook computers of increasing power and portability offer unique advantages to library users. Connecting easily to a campus data network, they are small silent work stations capable of drawing information from a variety of sources. Designers of new library buildings may assume that users in growing numbers will carry these multipurpose…

Chemical Space of DNA-Encoded Libraries.

PubMed

Franzini, Raphael M; Randolph, Cassie

2016-07-28

In recent years, DNA-encoded chemical libraries (DECLs) have attracted considerable attention as a potential discovery tool in drug development. Screening encoded libraries may offer advantages over conventional hit discovery approaches and has the potential to complement such methods in pharmaceutical research. As a result of the increased application of encoded libraries in drug discovery, a growing number of hit compounds are emerging in scientific literature. In this review we evaluate reported encoded library-derived structures and identify general trends of these compounds in relation to library design parameters. We in particular emphasize the combinatorial nature of these libraries. Generally, the reported molecules demonstrate the ability of this technology to afford hits suitable for further lead development, and on the basis of them, we derive guidelines for DECL design.

Solid-phase synthesis and chemical space analysis of a 190-membered alkaloid/terpenoid-like library

PubMed Central

Moura-Letts, Gustavo; DiBlasi, Christine M.; Bauer, Renato A.; Tan, Derek S.

2011-01-01

Alkaloid and terpenoid natural products display an extensive array of chemical frameworks and biological activities. However such scaffolds remain underrepresented in current screening collections and are, thus, attractive targets for the synthesis of natural product-based libraries that access underexploited regions of chemical space. Recently, we reported a systematic approach to the stereoselective synthesis of multiple alkaloid/terpenoid-like scaffolds using transition metal-mediated cycloaddition and cyclization reactions of enyne and diyne substrates assembled on a tert-butylsulfinamide lynchpin. We report herein the synthesis of a 190-membered library of alkaloid/terpenoid-like molecules using this synthetic approach. Translation to solid-phase synthesis was facilitated by the use of a tert-butyldiarylsilyl (TBDAS) linker that closely mimics the tert-butyldiphenysilyl protecting group used in the original solution-phase route development work. Unexpected differences in stereoselectivity and regioselectivity were observed in some reactions when carried out on solid support. Further, the sulfinamide moiety could be hydrolyzed or oxidized efficiently without compromising the TBDAS linker to provide additional amine and sulfonamide functionalities. Principal component analysis of the structural and physicochemical properties of these molecules confirmed that they access regions of chemical space that overlap with bona fide natural products and are distinct from areas addressed by conventional synthetic drugs and drug-like molecules. The influences of scaffolds and substituents were also evaluated, with both found to have significant impacts on location in chemical space and three-dimensional shape. Broad biological evaluation of this library will provide valuable insights into the abilities of natural product-based libraries to access similarly underexploited regions of biological space. PMID:21451137

Single service point: it's all in the design.

PubMed

Bradigan, Pamela S; Rodman, Ruey L

2008-01-01

"Design thinking" principles from a leading design firm, IDEO, were key elements in the planning process for a one-desk service model, the ASK Desk, at the John A. Prior Health Sciences Library. The library administration and staff employed the methodology to enhance customer experiences, meet technology challenges, and compete in a changing education environment. The most recent renovations demonstrate how the principles were applied. The concept of "continuous design thinking" is important in the library's daily operations to serve customers most effectively.

Facility Focus: Libraries.

ERIC Educational Resources Information Center

College Planning & Management, 2002

2002-01-01

Describes the design of the Charles V. Park Library at Central Michigan University and the Martha Rivers and E. Bronson Ingram Library, an addition to the Frederick Ferris Thompson Memorial Library at Vassar College. Discusses the libraries as examples of merging tradition with technology. Includes photographs. (EV)

Content and Design Features of Academic Health Sciences Libraries' Home Pages.

PubMed

McConnaughy, Rozalynd P; Wilson, Steven P

2018-01-01

The goal of this content analysis was to identify commonly used content and design features of academic health sciences library home pages. After developing a checklist, data were collected from 135 academic health sciences library home pages. The core components of these library home pages included a contact phone number, a contact email address, an Ask-a-Librarian feature, the physical address listed, a feedback/suggestions link, subject guides, a discovery tool or database-specific search box, multimedia, social media, a site search option, a responsive web design, and a copyright year or update date.

PrecisePrimer: an easy-to-use web server for designing PCR primers for DNA library cloning and DNA shuffling.

PubMed

Pauthenier, Cyrille; Faulon, Jean-Loup

2014-07-01

PrecisePrimer is a web-based primer design software made to assist experimentalists in any repetitive primer design task such as preparing, cloning and shuffling DNA libraries. Unlike other popular primer design tools, it is conceived to generate primer libraries with popular PCR polymerase buffers proposed as pre-set options. PrecisePrimer is also meant to design primers in batches, such as for DNA libraries creation of DNA shuffling experiments and to have the simplest interface possible. It integrates the most up-to-date melting temperature algorithms validated with experimental data, and cross validated with other computational tools. We generated a library of primers for the extraction and cloning of 61 genes from yeast DNA genomic extract using default parameters. All primer pairs efficiently amplified their target without any optimization of the PCR conditions. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

Key Aspects of Nucleic Acid Library Design for in Vitro Selection

PubMed Central

Vorobyeva, Maria A.; Davydova, Anna S.; Vorobjev, Pavel E.; Pyshnyi, Dmitrii V.; Venyaminova, Alya G.

2018-01-01

Nucleic acid aptamers capable of selectively recognizing their target molecules have nowadays been established as powerful and tunable tools for biospecific applications, be it therapeutics, drug delivery systems or biosensors. It is now generally acknowledged that in vitro selection enables one to generate aptamers to almost any target of interest. However, the success of selection and the affinity of the resulting aptamers depend to a large extent on the nature and design of an initial random nucleic acid library. In this review, we summarize and discuss the most important features of the design of nucleic acid libraries for in vitro selection such as the nature of the library (DNA, RNA or modified nucleotides), the length of a randomized region and the presence of fixed sequences. We also compare and contrast different randomization strategies and consider computer methods of library design and some other aspects. PMID:29401748

Discovery of potent inhibitors of soluble epoxide hydrolase by combinatorial library design and structure-based virtual screening.

PubMed

Xing, Li; McDonald, Joseph J; Kolodziej, Steve A; Kurumbail, Ravi G; Williams, Jennifer M; Warren, Chad J; O'Neal, Janet M; Skepner, Jill E; Roberds, Steven L

2011-03-10

Structure-based virtual screening was applied to design combinatorial libraries to discover novel and potent soluble epoxide hydrolase (sEH) inhibitors. X-ray crystal structures revealed unique interactions for a benzoxazole template in addition to the conserved hydrogen bonds with the catalytic machinery of sEH. By exploitation of the favorable binding elements, two iterations of library design based on amide coupling were employed, guided principally by the docking results of the enumerated virtual products. Biological screening of the libraries demonstrated as high as 90% hit rate, of which over two dozen compounds were single digit nanomolar sEH inhibitors by IC(50) determination. In total the library design and synthesis produced more than 300 submicromolar sEH inhibitors. In cellular systems consistent activities were demonstrated with biochemical measurements. The SAR understanding of the benzoxazole template provides valuable insights into discovery of novel sEH inhibitors as therapeutic agents.

NCSTRL: Design and Deployment of a Globally Distributed Digital Library.

ERIC Educational Resources Information Center

Davies, James R.; Lagoze, Carl

2000-01-01

Discusses the development of a digital library architecture that allows the creation of digital libraries within the World Wide Web. Describes a digital library, NCSTRL (Networked Computer Science Technical Research Library), within which the work has taken place and explains Dienst, a protocol and architecture for distributed digital libraries.…

A Report on New Haven's Library Neighborhood Centers.

ERIC Educational Resources Information Center

Bloss, Meredith

A library neighborhood center is a community built around a branch library, providing the usual branch library functions of self-education and improvement. Four of New Haven's eight branch libraries are designed as library neighborhood centers. The centers are supported by the Ford Foundation, the City of New Haven, the Office of Economic…

12 CFR 352.2 - Application.

Code of Federal Regulations, 2010 CFR

2010-01-01

..., or participation by, members of the public: (1) Attending Board of Directors meetings open to the... Legislative Affairs and Office of Public Affairs; (3) Using the FDIC library in Washington, DC; (4) Using the...

12 CFR 352.2 - Application.

Code of Federal Regulations, 2011 CFR

2011-01-01

..., or participation by, members of the public: (1) Attending Board of Directors meetings open to the... Legislative Affairs and Office of Public Affairs; (3) Using the FDIC library in Washington, DC; (4) Using the...

'There is a dependent patient in our home': designing and disseminating a family caregiving program through YouTube.

PubMed

Abu Kamel, Andaleeb

2016-06-01

Family members play a major role in providing care for older people and long-term dependent patients, especially in developing countries where there is a lack of specialized nursing homes and specialized home-visiting programs. Family members are rarely provided with sufficient information or training to provide home care for their dependent relatives. There are inadequate home caregiving educational resources directed to Arabic-speaking caregivers, either in written or in audiovisual presentations. The aims of the present study were (i) to present the process of designing a caregiving educational program entitled 'there is a dependent patient in our home', with an intention to be culturally and linguistically appropriate for a specific Arab-speaking population, and (ii) to present the experience of disseminating the program through YouTube, to be accessible for a wide range of caregivers. The program was a product of a process involving seven phases, starting with a review of the literature and ending with disseminating 17 short 'caregiving' videos on YouTube, the most popular video-sharing website. The program presented necessary skills, instructions, and information that enabled caregivers to provide safe and competent daily caring activities for their functionally dependent relative or older adults at home. The program was registered in the Jordan National Library. After 2 months of broadcasting it on YouTube, the number of views exceeded 6800. Many constructive comments were received from caregivers. Language, simplicity, and attractiveness of the program were judged as the areas of satisfaction by the viewers, whereas lack of a few topics such as verbal communication with patients and dealing with daily caregivers' burden and stressors were the main reasons of dissatisfaction. This program was an endeavor to provide the Arabic library with a home caregiving resource. Adequate advertisement of the program would encourage health providers to search for and use the currently available social media as means of delivering educational services to family caregivers.

NASA and Public Libraries: Enhancing STEM Literacy in Underserved Communities

NASA Astrophysics Data System (ADS)

Dusenbery, P.; LaConte, K.; Harold, J. B.; Randall, C.

2016-12-01

NASA research programs are helping humanity understand the origin and evolution of galaxies, stars, and planets, and defining the conditions necessary to support life beyond Earth. The Space Science Institute's (SSI) National Center for Interactive Learning (NCIL) was recently funded by NASA`s Science Mission Directorate (SMD) to develop and implement a project called NASA@ My Library: A National Earth and Space Science Initiative That Connects NASA, Public Libraries and Their Communities. As places that offer their services for free, public libraries have become the "public square" by providing a place where members of a community can gather for information, educational programming, and policy discussions. Libraries are developing new ways to engage their patrons in STEM learning, and NCIL's STAR Library Education Network (STAR_Net) has been supporting their efforts for the last eight years, including through a vibrant community of practice that serves both librarians and STEM professionals. Project stakeholders include public library staff, state libraries, the earth and space science education community at NASA, subject matter experts, and informal science educators. The project will leverage high-impact SMD and library events to catalyze partnerships through dissemination of SMD assets and professional development. It will also develop frameworks for public libraries to increase STEM interest pathways in their communities (with supports for reaching underserved audiences). This presentation will summarize the key activities and expected outcomes of the 5-year project.

Diversity of ribosomal 16S DNA- and RNA-based bacterial community in an office building drinking water system.

PubMed

Inkinen, J; Jayaprakash, B; Santo Domingo, J W; Keinänen-Toivola, M M; Ryu, H; Pitkänen, T

2016-06-01

Next-generation sequencing of 16S ribosomal RNA genes (rDNA) and ribosomal RNA (rRNA) was used to characterize water and biofilm microbiome collected from a drinking water distribution system of an office building after its first year of operation. The total bacterial community (rDNA) and active bacterial members (rRNA) sequencing databases were generated by Illumina MiSeq PE250 platform. As estimated by Chao1 index, species richness in cold water system was lower (180-260) in biofilms (Sphingomonas spp., Methylobacterium spp., Limnohabitans spp., Rhizobiales order) than in waters (250-580), (also Methylotenera spp.) (P = 0·005, n = 20). Similarly species richness (Chao1) was slightly higher (210-580) in rDNA libraries compared to rRNA libraries (150-400; P = 0·054, n = 24). Active Mycobacterium spp. was found in cross-linked polyethylene (PEX), but not in corresponding copper pipeline biofilm. Nonpathogenic Legionella spp. was found in rDNA libraries but not in rRNA libraries. Microbial communities differed between water and biofilms, between cold and hot water systems, locations in the building and between water rRNA and rDNA libraries, as shown by clear clusters in principal component analysis (PcoA). By using the rRNA method, we found that not all bacterial community members were active (e.g. Legionella spp.), whereas other members showed increased activity in some locations; for example, Pseudomonas spp. in hot water circulations' biofilm and order Rhizobiales and Limnohabitans spp. in stagnated locations' water and biofilm. rRNA-based methods may be better than rDNA-based methods for evaluating human health implications as rRNA methods can be used to describe the active bacterial fraction. This study indicates that copper as a pipeline material might have an adverse impact on the occurrence of Mycobacterium spp. The activity of Legionella spp. maybe questionable when detected solely by using DNA-based methods. © 2016 The Society for Applied Microbiology.

Determinants of BH3 binding specificity for Mcl-1 vs. Bcl-xL

PubMed Central

Dutta, Sanjib; Gullá, Stefano; Chen, T. Scott; Fire, Emiko; Grant, Robert A.; Keating, Amy E.

2010-01-01

Interactions among Bcl-2 family proteins are important for regulating apoptosis. Pro-survival members of the family interact with pro-apoptotic BH3-only members, inhibiting execution of cell death through the mitochondrial pathway. Structurally, this interaction is mediated by binding of the alpha-helical BH3 region of the pro-apoptotic proteins to a conserved hydrophobic groove on the pro-survival proteins. Native BH3-only proteins exhibit selectivity in binding pro-survival members, as do small molecules that block these interactions. Understanding the sequence and structural basis of interaction specificity in this family is important, as it may allow the prediction of new Bcl-2 family associations and/or the design of new classes of selective inhibitors to serve as reagents or therapeutics. In this work we used two complementary techniques, yeast surface display screening from combinatorial peptide libraries and SPOT peptide array analysis, to elucidate specificity determinants for binding to Bcl-xL vs. Mcl-1, two prominent pro-survival proteins. We screened a randomized library and identified BH3 peptides that bound to either Mcl-1 or Bcl-xL selectively, or to both with high affinity. The peptides competed with native ligands for binding into the conserved hydrophobic groove, as illustrated in detail by a crystal structure of a specific peptide bound to Mcl-1. Mcl-1 selective peptides from the screen were highly specific for binding Mcl-1 in preference to Bcl-xL, Bcl-2, Bcl-w and Bfl-1, whereas Bcl-xL selective peptides showed some cross-interaction with related proteins Bcl-2 and Bcl-w. Mutational analyses using SPOT arrays revealed the effects of 170 point mutations made in the background of a peptide derived from the BH3 region of Bim, and a simple predictive model constructed using these data explained much of the specificity observed in our Mcl-1 vs. Bcl-xL binders. PMID:20363230

Usability Studies and User-Centered Design in Digital Libraries

ERIC Educational Resources Information Center

Comeaux, David J.

2008-01-01

Digital libraries continue to flourish. At the same time, the principles of user-centered design and the practice of usability testing have been growing in popularity, spreading their influence into the library sphere. This article explores the confluence of these two trends by surveying the current literature on usability studies of digital…

Problem Scoping Design Thinking and Close Reading: Makerspaces in the School Library

ERIC Educational Resources Information Center

Blakemore, Megan

2018-01-01

Makerspaces, collaborative workspaces stocked with materials and tools for creating, building, designing, and learning, are becoming more and more common in schools and, in particular, in school libraries. Makerspaces in the school library allow for connections between making and literacy. Indeed, such connections are authentic and natural as…

Toward a User-Centered Academic Library Home Page

ERIC Educational Resources Information Center

McHale, Nina

2008-01-01

In the past decade, academic libraries have struggled with the design of an effective library home page. Since librarians' mental models of information architecture differ from those of their patrons, usability assessments are necessary in designing a user-centered home page. This study details a usability sequence of card sort and paper and…

Planning library spaces to encourage collaboration

PubMed Central

Adamson, Martha C.; Bunnett, Brian P.

2002-01-01

Most librarians can give examples from their own experience in which a library's physical space was either ill suited to the work to be performed or, in some unfortunate cases, a genuine barrier to productivity. In an effort to correct or avoid these situations, planners of library renovations or new construction make pre-design studies of individual workers' tasks and workflow at the work-unit level. In this article, the authors discuss how a pre-design review of library and institutional values influenced the course of a library renovation. The identification of collaboration as the major theme of the library and the institution's strategic directions drove renovation decisions and resulted in a facility that supports and promotes this concept. PMID:12398250

Library Buildings.

ERIC Educational Resources Information Center

Manley, Will; And Others

1989-01-01

The innovative designs of three libraries are described: the Tempe (Arizona) Public Library, which emphasizes services for children and students; an underground library at Park College, Missouri; and a public library located in the Vancouver (Washington) Mall. The fourth article describes the work going on to restore the Los Angeles (California)…

Users' Satisfaction with Library Services: A Case Study of Delta State University Library

ERIC Educational Resources Information Center

Ikolo, Violet E.

2015-01-01

The study focused on users' satisfaction with library services at the Delta State University main Library, Abraka, Delta State. The objective was to find out if users are satisfied with the services, facilities, the library environment, information sources and staff of the library. Using the descriptive survey design, the population for the study…

The Library Work Order Processing System: A New Approach to Motivate Employees and to Increase Production in the Technical Service Department of Mercer County Community College Library. Applied Educational Research and Evaluation.

ERIC Educational Resources Information Center

Sim, Yong Sup

After reviewing the current movement toward job enrichment, a system was designed for the technical services department of the Mercer County Community College Library. The Library Work Order Processing System, as tried between January and March, 1974, was designed to permit each worker more variety of jobs. The technical services department was…

The librarian as research informationist: a case study.

PubMed

Federer, Lisa

2013-10-01

How can an embedded research informationist add value to the scientific output of research teams? The University of California-Los Angeles (UCLA) Louise M. Darling Biomedical Library is an academic health sciences library serving the clinical, educational, and research needs of the UCLA community. A grant from the National Library of Medicine funded a librarian to join a UCLA research team as an informationist. The informationist meets regularly with the research team and provides guidance related to data management, preservation, and other information-related issues. Early results suggest that the informationist's involvement has influenced the team's data gathering, storage, and curation methods. The UCLA Library has also changed the librarian's title to research informationist to reflect the new activities that she performs. The research informationist role provides an opportunity for librarians to become effective members of research teams and improve research output.

Research engagement of health sciences librarians: a survey of research-related activities and attitudes.

PubMed

Lessick, Susan; Perryman, Carol; Billman, Brooke L; Alpi, Kristine M; De Groote, Sandra L; Babin, Ted D

2016-04-01

The extent to which health sciences librarians are engaged in research is a little-studied question. This study assesses the research activities and attitudes of Medical Library Association (MLA) members, including the influence of work affiliation. An online survey was designed using a combination of multiple-choice and open-ended questions and distributed to MLA members. Responses were analyzed using descriptive statistics, content analysis, and significance testing. The authors used statistical tools and categorized open-ended question topics by the constant comparative method, also applying the broad subject categories used in a prior study. Pearson's chi-square analysis was performed on responses to determine significant differences among respondents employed in three different institutional environments. Analysis showed that 79% of respondents read research articles at least once a month; 58% applied published research studies to practice; 44% had conducted research; 62% reported acting on research had enhanced their libraries; 38% had presented findings; and 34% had authored research articles. Hospital librarians were significantly less likely than academic librarians to have participated in research activities. Highly ranked research benefits, barriers, and competencies of health sciences librarians are described. Findings indicate that health sciences librarians are actively engaged in research activities. Practice implications for practitioners, publishers, and stakeholders are discussed. Results suggest that practitioners can use published research results and results from their own research to affect practice decisions and improve services. Future studies are needed to confirm and extend these findings, including the need for intervention studies to increase research and writing productivity.

Research engagement of health sciences librarians: a survey of research-related activities and attitudes

PubMed Central

Lessick, Susan; Perryman, Carol; Billman, Brooke L.; Alpi, Kristine M.; De Groote, Sandra L.; Babin, Ted D.

2016-01-01

Introduction The extent to which health sciences librarians are engaged in research is a little-studied question. This study assesses the research activities and attitudes of Medical Library Association (MLA) members, including the influence of work affiliation. Methods An online survey was designed using a combination of multiple-choice and open-ended questions and distributed to MLA members. Responses were analyzed using descriptive statistics, content analysis, and significance testing. The authors used statistical tools and categorized open-ended question topics by the constant comparative method, also applying the broad subject categories used in a prior study. Pearson's chi-square analysis was performed on responses to determine significant differences among respondents employed in three different institutional environments. Results Analysis showed that 79% of respondents read research articles at least once a month; 58% applied published research studies to practice; 44% had conducted research; 62% reported acting on research had enhanced their libraries; 38% had presented findings; and 34% had authored research articles. Hospital librarians were significantly less likely than academic librarians to have participated in research activities. Highly ranked research benefits, barriers, and competencies of health sciences librarians are described. Conclusions Findings indicate that health sciences librarians are actively engaged in research activities. Practice implications for practitioners, publishers, and stakeholders are discussed. Results suggest that practitioners can use published research results and results from their own research to affect practice decisions and improve services. Future studies are needed to confirm and extend these findings, including the need for intervention studies to increase research and writing productivity. PMID:27076808

A Robust and Versatile Method of Combinatorial Chemical Synthesis of Gene Libraries via Hierarchical Assembly of Partially Randomized Modules

PubMed Central

Popova, Blagovesta; Schubert, Steffen; Bulla, Ingo; Buchwald, Daniela; Kramer, Wilfried

2015-01-01

A major challenge in gene library generation is to guarantee a large functional size and diversity that significantly increases the chances of selecting different functional protein variants. The use of trinucleotides mixtures for controlled randomization results in superior library diversity and offers the ability to specify the type and distribution of the amino acids at each position. Here we describe the generation of a high diversity gene library using tHisF of the hyperthermophile Thermotoga maritima as a scaffold. Combining various rational criteria with contingency, we targeted 26 selected codons of the thisF gene sequence for randomization at a controlled level. We have developed a novel method of creating full-length gene libraries by combinatorial assembly of smaller sub-libraries. Full-length libraries of high diversity can easily be assembled on demand from smaller and much less diverse sub-libraries, which circumvent the notoriously troublesome long-term archivation and repeated proliferation of high diversity ensembles of phages or plasmids. We developed a generally applicable software tool for sequence analysis of mutated gene sequences that provides efficient assistance for analysis of library diversity. Finally, practical utility of the library was demonstrated in principle by assessment of the conformational stability of library members and isolating protein variants with HisF activity from it. Our approach integrates a number of features of nucleic acids synthetic chemistry, biochemistry and molecular genetics to a coherent, flexible and robust method of combinatorial gene synthesis. PMID:26355961

IAC Library: Some Challenges

NASA Astrophysics Data System (ADS)

Gomez, M.

2010-10-01

Since its beginnings in 1985, the IAC Library has evolved from a traditional library where the physical place and collections were essential, to a hybrid library where users can often get what they need without going to the library. In this paper, we present how the various changes due to information technology advances that occurred in the 1990s, followed by a series of works carried out from 2004 to 2008 at IAC, as well as several internal and external events or decisions, have led the IAC Library to face three new challenges. First, as the library building has been enlarged and new spaces are now available for users and for shelving, we have to decide what we should we do with the new spaces. How we can make them attractive for users at a time when users often don't need to visit the library to access the information they need? Second, as IAC will implement a new integrated information system, we have an opportunity to define how the library system will participate within the IAC global information system, bringing to this great project our knowledge of information management, essential to improve the actual processes. Third, as the Ministry has created a working group on access to electronic resources, with participation by seven affiliated research institutions, we have, as a member of this group, to define how to deal with the Ministry and the other centres to set a library policy that will benefit the IAC Library.

A Robust and Versatile Method of Combinatorial Chemical Synthesis of Gene Libraries via Hierarchical Assembly of Partially Randomized Modules.

PubMed

Popova, Blagovesta; Schubert, Steffen; Bulla, Ingo; Buchwald, Daniela; Kramer, Wilfried

2015-01-01

A major challenge in gene library generation is to guarantee a large functional size and diversity that significantly increases the chances of selecting different functional protein variants. The use of trinucleotides mixtures for controlled randomization results in superior library diversity and offers the ability to specify the type and distribution of the amino acids at each position. Here we describe the generation of a high diversity gene library using tHisF of the hyperthermophile Thermotoga maritima as a scaffold. Combining various rational criteria with contingency, we targeted 26 selected codons of the thisF gene sequence for randomization at a controlled level. We have developed a novel method of creating full-length gene libraries by combinatorial assembly of smaller sub-libraries. Full-length libraries of high diversity can easily be assembled on demand from smaller and much less diverse sub-libraries, which circumvent the notoriously troublesome long-term archivation and repeated proliferation of high diversity ensembles of phages or plasmids. We developed a generally applicable software tool for sequence analysis of mutated gene sequences that provides efficient assistance for analysis of library diversity. Finally, practical utility of the library was demonstrated in principle by assessment of the conformational stability of library members and isolating protein variants with HisF activity from it. Our approach integrates a number of features of nucleic acids synthetic chemistry, biochemistry and molecular genetics to a coherent, flexible and robust method of combinatorial gene synthesis.