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Sample records for merece dr enrique

  1. "A century of civilization under the influence of eugenics": Dr. Enrique Diego Madrazo, socialism and scientific progress.

    PubMed

    Cleminson, Richard

    2006-01-01

    This article discusses the thought of one of the pioneers of eugenics in Spain, Dr. Enrique Diego Madrazo. In particular, it analyses his 1930 essay Un siglo de civilización bajo la influencia eugenésica [A Century of Civilization under the Influence of Eugenics], as the most explicit work on the eugenic utopia he advocated. This work, because of its breadth, was also one of the most extensive and detailed accounts of the steps to be taken towards the eugenic society that was produced. The present analysis of his work assesses the degree to which his thought, which has been described as "utopian socialist", in fact corresponded to that epithet, given the politically authoritarian nature and the gender bias of some aspects of his one-hundred year plan for the creation of a eugenic society. The article also places Madrazo's thought in the context of his time and other national currents of eugenic thought.

  2. Obituary -- Enrique Chavira Navarrete

    NASA Astrophysics Data System (ADS)

    Carramiñana, A.

    2001-04-01

    During the twentieth century, Mexican astronomical observatories migrated Tonantzintla and from there to the selected mountain sites of San Pedro Mártir and Cananea. In Tonantzintla Mexican astronomy progressed from cosmography to astrophysics. There, during the fifties and sixties, Guillermo Haro used the Schmidt camera to place México in the astronomical map. Instrumental to this process was Enrique Chavira, whose scientific life almost exactly matched the second half of the century which has just finished, going from the pioneer times of the Tonantzintla Astrophysical Observatory to the fully developed Mexican astronomy of the dawn of the XXI century. Enrique Chavira died unexpectedly 38 days before the turn of the century. Even though his heart had shown past weaknesses, his daily presence in the corridors of the Tonantzintla Institute somehow led us to believe he would always be here. Chavira was the most senior of the astronomers at Tonantzintla and, though he never entered the decision circles, he always had an opinion, frequently ironic, about the main problems of the Instituto. I do remember more than one occasion Alfonso Serrano asking for the advice of Chavira, seeking the experience of the former assistant of Don Guillermo Haro. Born and raised in México City, Chavira eventually moved to Puebla, the closest large city to Tonantzintla, following the steps of Mexican observational astronomy. Without concluding his formal studies, Chavira managed to adjudicate for himself the title of ``astrónomo'', earning it with his skillful handling of the Schmidt camera and the photographic plates. Over the years he took over 8000 astronomical plates, which is a little more than half of the precious Tonantzintla collection. Even though Chavira was aware of his limitations, his ability in photographic astronomy made him a recognized astronomer. The list of his co-authors includes, apart from Guillermo Haro, other renamed astronomers like Manuel Peimbert, Luis

  3. [The civil role of experimental rationalism in the work of Federigo Enriques].

    PubMed

    Gattinara, Enrico Castelli

    2011-01-01

    Scientific knowledge and philosophic knowledge have an ethical responsibility that should not be disregarded. This observation made by scholar-philosophers such as Henri Poincaré and Federigo Enriques has experienced an importance of which 20(th) century epistemology has been unaware. It is important to relaunch this observation in the name of older values: equality, democracy, openness, research without dogmatic boundaries. The analysis of the work of Enriques enables us to grasp the stakes of such an endeavor.

  4. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher von Braun with Dr. Eberhard Rees and R.W. Cook at a press conference concerning Dr. Von Braun's assignment to NASA headquarters and Dr. Rees' subsequent assignment as Marshall Center director.

  5. Dr. Wernher Von Braun with Dr. Christian Barnard.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Christian Barnard Tours Marshall Space Flight Center. Shown in Dr. Von Braun's office are (left to right): Dr. Ernst Sthulinger, a representative from General Electric, Dr. Wernher Von Braun, Dr. Christian Barnard, and Dr. Eberhard Rees.

  6. Large Customers (DR Sellers)

    SciTech Connect

    Kiliccot, Sila

    2011-10-25

    State of the large customers for demand response integration of solar and wind into electric grid; openADR; CAISO; DR as a pseudo generation; commercial and industrial DR strategies; California regulations

  7. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Thomas Paine, Deputy Administrator of the National Aeronautics and Space Administration, examines an ordinary man's shoe outfitted for use in the Saturn I workshop. Pictured from the left in the Saturn I workshop mockup are William Brooksbank, propulsion and vehicle engineering laboratory; Dr. Paine; Dr. Wernher Von Braun, Marshall Center director; Colonel Clare F. Farley, Executive Officer in the Office Of The Administrator; and Charles J. Donlan, Deputy Associate Administrator for Manned Space Flight, Technical. the shoe Dr. Paine is holding has a unique fastener built into the sole to allow an astronaut to move about on the workshop floor and to remain in one position if he desires.

  8. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun (left) and Fred W. Kelley examine a ST-100 Stellar Instrument Platform in the astrionics lab. Dr. Von Braun, then deputy associate administrator for planning, NASA, was visiting on the anniversary of the establishment of the Marshall Space Flight Center.

  9. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Shown viewing the Apollo telescope mockup are, from left to right, Charles Donlan, deputy associate administrator for manned space flight; Dr. Wernher Von Braun, Marshall Space Flight Center director; William Horton, astrionics lab; Dr. Thomas Paine, NASA deputy administrator; Warner Kuers, director of the ME lab.

  10. Dr. Daniel Carter

    NASA Technical Reports Server (NTRS)

    1998-01-01

    Dr. Daniel Carter, president of New Century Pharmaceuticals in Huntsville, Al, is one of three principal investigators in NASA's microgravity protein crystal growth program. Dr. Carter's experties is in albumins. Albumins are proteins in the bloodstream that transport materials, drugs, nutrients, and wastes. Photo credit: NASA/Marshall Space Flight Center

  11. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1968-01-01

    Dr. Wernher Von Braun, stands in front of a Saturn IB Launch Vehicle at Kennedy Space Center (KSC). Dr. Von Braun was Marshall's first Center Director (1960-1970). Under his leadership Marshall was responsible for the development of the Saturn rockets, the Skylab project and getting the United States into Space and landing on the moon with the Apollo missions.

  12. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun (right), Deputy Associate Administrator for planning, National Aeronautics and Space Administration, inspects the mockup of the Saturn Workshop during a visit marking the 10th anniversary of the Marshall Center. Shown with Dr. Von Braun, from left to right, are Karl Heimburg, Director of the astronautics lab; Herman K. Weidner, Director of Science and Engineering, and George Hardy of the Astronautics lab.

  13. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun (right), Deputy Associate Administrator for Planning, National Aeronautics and Space Administration, inspects the mockup of the Saturn Workshop during a visit marking the 10th anniversary of the Marshall Center. Shown with Dr. Von Braun, from left to right, are Karl Heimburg, Director of the Astronautics Lab; Herman K. Weidner, Director of Science and Engineering, and George Hardy of the Astronautics Lab.

  14. Dr. Wernher von Braun

    NASA Technical Reports Server (NTRS)

    2004-01-01

    Dr. von Braun is looking out from a 10th floor window of building 4200 at the Marshall Space Flight Center (MSFC). He was the first Center Director and served as the Director from July 1960 through February 1970. Following World War II, Dr. von Braun and his German colleagues arrived in the United States under the Project Paperclip (American acquisition of German rocket experts) to continue their rocket development work. In 1950, von Braun and his German Rocket Team (also called the Peenemuende Team) were transferred from Ft. Bliss, Texas to Huntsville, Alabama to work for the Army's rocket program at Redstone Arsenal and later, NASA's Marshall Space Flight Center (MSFC). Under Dr. von Braun's leadership, MSFC developed the Saturn V launch vehicle, which placed the first men, two American astronauts, on the Moon. Wernher von Braun's life was dedicated to expanding man's knowledge through the exploration of space.

  15. Dr Pugh: a poisoner?

    PubMed

    Paull, J D; Morris, G M

    2012-07-01

    On 16 February 1845 the Reverend W. H. Browne, rector of St John's Church in Launceston, Van Diemen's Land, wrote in his journal, "My dear Wife died very suddenly almost immediately after and in consequence of taking a preparation of Hyd. Cyan. Acid prepared & supplied by Dr Pugh". This journal entry raises a number of questions. Was Dr Pugh treating a condition which he thought merited that treatment or was it a ghastly mistake? Was Caroline Browne suffering from pulmonary tuberculosis? Was hydrocyanic acid an accepted treatment at that time? Did Mrs Browne take the wrong dose? Was an incorrect concentration of the drug prepared by Dr Pugh? Did he use the wrong pharmacopoeia in preparing the hydrocyanic acid? Why was there no inquest? Only some of these questions can be answered. PMID:23230685

  16. Dr. Eberhard Rees

    NASA Technical Reports Server (NTRS)

    1970-01-01

    Dr. Eberhard Rees served as director of the Marshall Space Flight Center from March 1, 1970 until January 19, 1973 when he retired from NASA. Prior to his appointment as Director, Rees served as the Center's deputy director under Dr. Wernher von Braun, 1960-1970. Rees came to the United States as part of the Dr. Wernher von Braun's German Rocket team following World War II. He transferred to Huntsville, Alabama from Fort Bliss, Texas in 1950 to work for the Army's rocket program at Redstone Arsenal. From 1956 to 1960 he served as deputy director of development operations at the Army Ballistic Missile Agency under von Braun. In 1960 Rees was transferred to NASA's Marshall Center.

  17. Dr Pugh: a poisoner?

    PubMed

    Paull, J D; Morris, G M

    2012-07-01

    On 16 February 1845 the Reverend W. H. Browne, rector of St John's Church in Launceston, Van Diemen's Land, wrote in his journal, "My dear Wife died very suddenly almost immediately after and in consequence of taking a preparation of Hyd. Cyan. Acid prepared & supplied by Dr Pugh". This journal entry raises a number of questions. Was Dr Pugh treating a condition which he thought merited that treatment or was it a ghastly mistake? Was Caroline Browne suffering from pulmonary tuberculosis? Was hydrocyanic acid an accepted treatment at that time? Did Mrs Browne take the wrong dose? Was an incorrect concentration of the drug prepared by Dr Pugh? Did he use the wrong pharmacopoeia in preparing the hydrocyanic acid? Why was there no inquest? Only some of these questions can be answered.

  18. 1. View of three detection radar (DR) antennas. DR 1 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. View of three detection radar (DR) antennas. DR 1 (structure no. 735) on left, DR 2 (structure no. 736) in center, and DR 3 (structure no. 737) looking north 30 degrees west, with tracking radar (large radome) and satcom (satellite communication) system in small radome in view between DR 2 and DR 3 antennae. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  19. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1999-01-01

    A camerman catches Dr. Wernher Von Braun, Director of the Marshall Space Flight Center, his son, Peter, and daughter, Martgrit, as they arrive at the employee picnic held to celebrate man's first landing on the moon 6 days earlier. In the foreground is David R. Newby, Director of Administration and Technical Services at the Marshall Space Flight Center.

  20. Dr. Goddard Transports Rocket

    NASA Technical Reports Server (NTRS)

    1974-01-01

    Dr. Robert H. Goddard tows his rocket to the launching tower behind a Model A Ford truck, 15 miles northwest of Roswell, New Mexico. 1930- 1932. Dr. Goddard has been recognized as the 'Father of American Rocketry' and as one of three pioneers in the theoretical exploration of space. Robert Hutchings Goddard was born in Worcester, Massachusetts, on October 15, 1882. He was a theoretical scientist as well as a practical engineer. His dream was the conquest of the upper atmosphere and ultimately space through the use of rocket propulsion. Dr. Goddard, who died in 1945, was probably as responsible for the dawning of the Space Age as the Wright Brothers were for the begining of the Air Age. Yet his work attracted little serious attention during his lifetime. When the United States began to prepare for the conquest of space in the 1950's, American rocket scientists began to recognize the debt owed to the New England professor. They discovered that it was virtually impossible to construct a rocket or launch a satellite without acknowledging the work of Dr. Goddard. This great legacy was covered by more than 200 patents, many of which were issued after his death.

  1. Ask Dr. Sue.

    ERIC Educational Resources Information Center

    Aronson, Susan S.

    1990-01-01

    Discusses the need for child care providers to be sure children in their care who are between the ages of 15 months and 5 years have had Haemophilus influenzae type b (Hib) vaccine. Urges child care center staff to avoid use of bean bag infant cushions and to inform parents about the hazards posed by the cushions. (DR)

  2. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1968-01-01

    Dr. Wernher von Braun, Director of the Marshall Space Flight Center, explains the purpose of a thermal curtain in the mockup of a Saturn I workshop to U.S. Representative Armistead Seldon of Alabama. The Congressman visited the Marshall Center on March 2, 1968 to tour the workshop and to visit Marshall Center facilities.

  3. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1968-01-01

    U.S. Representative Armistead Seldon (D.-Al) inspects the food preparation area of the Saturn I workshop mockup during a visit to the Marshall Space Flight Center. Explaining the operation of the food preparation area to the congressman is Dr. Wernher Von Braun, Marshall Space Flight Center director.

  4. Dr. Faustus: Theist or Atheist?

    ERIC Educational Resources Information Center

    Karim, Shah Mohammad Sanaul; Fathema, Fawzia; Hakim, Abdul

    2015-01-01

    Dr. Faustus is the greatest but the most controversial of Marlowe's plays. Among the causes of controversy, whether Dr. Faustus is an atheist or theist deserves utmost attention. This paper is intended to deal with the issue. Though at various stages of the development of the action, Dr. Faustus abjures Trinity, resorts to necromancy, becomes…

  5. Intertextual Sexual Politics: Illness and Desire in Enrique Gomez Carrillo's "Del amor", "del dolor y del vicio" and Aurora Caceres's "La rosa muerta"

    ERIC Educational Resources Information Center

    LaGreca, Nancy

    2012-01-01

    This study explores the intertextuality between Aurora Caceres's "La rosa muerta" (1914) and the novel "Del amor, del dolor y del vicio" (1898) by her ex-husband, Enrique Gomez Carrillo. Caceres strategically mentions Gomez Carrillo's novel in "La rosa muerta" to invite a reading of her work in dialogue with his. Both narratives follow the sexual…

  6. Teaching Peace with Dr. Seuss.

    ERIC Educational Resources Information Center

    Pace, Rosemarie; Podesta, Andrea

    1999-01-01

    Educators seeking novel ways to instill conflict-resolution skills in young children should consider Dr. Seuss, whose books provide a synthesis of fantasy and reality that works for teaching values endemic to peace education. This paper discusses how students can learn peace and educators can teach peace using Dr. Seuss books, examining steps to…

  7. Dr. Barnett's dream

    SciTech Connect

    Wilson, A.

    1990-04-01

    In 1986, AstroPower was a tiny R D company located at the University of Delaware. Like many other entrepreneurs in the field at that time, the company's president, Dr. Allen Barnett, had a good idea, a good research staff, and the dream of becoming a successful manufacturer of photovoltaic (PV) cells. If the Newark, Del. company's projections remain on track, Barnett plans to become the third largest PV manufacturer in the United States by the end of next year. Were it not for the company's performance to date, such a claim might well be dismissed as idle dreaming. AstroPower Inc. is pursuing a two-pronged strategy: to rapidly bring a new thin-crystal silicon PV cell to commercialization; and, in the meantime, to gain experience in manufacturing and distributing conventional single-crystal and polycrystal silicon cells. The company sold approximately 200 kilowatts (kWp) of cells last year (about half single-crystal and half polycrystal). Its current production capacity is 360 kWp. The company and its products are described.

  8. 5. View of middle DR 2 antenna with DR 1 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. View of middle DR 2 antenna with DR 1 antenna in background. Photograph shows on left side at bottom foundation berm and along right side bottom stanchion concrete foundations at bottom structural steel assembly. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  9. Dr. John Richardson: Arctic Doctor

    PubMed Central

    Houston, C. Stuart

    1988-01-01

    Dr. John Richardson was foremost among a special breed of men, the surgeon-naturalists, one of whom accompanied every exploration party sent out by Great Britain. In addition to performing medical duties, the surgeon-naturalist was expected to identify and collect specimens of plants, animals, and rocks. Dr. Richardson was a member of two of the arctic expeditions led by Sir John Franklin, and participated in the search for the long-overdue third Franklin expedition. ImagesFigure 1 PMID:21253036

  10. Wally Schirra Greets Dr. Wernher von Braun

    NASA Technical Reports Server (NTRS)

    1968-01-01

    Apollo 7 Commander Walter M. Schirra, Jr., left, greets Dr. Wernher Von Braun, Director, Marshall Space Flight Center and Dr. Kurt Debus, Right, KSC Director, during a prelaunch mission briefing held at the Florida Spaceport.

  11. White Dwarfs in SDSS DR9 and DR10

    NASA Astrophysics Data System (ADS)

    Gentile Fusillo, Nicola Pietro; Gänsicke, Boris; Koester, Detlev

    2015-06-01

    Currently the largest catalogue of spectroscopically identified WDs is based on the 7th Data Release (DR) of the Sloan Digital Sky Survey and contains over 20000 WDs (Kleinman et al. 2013). However, only a fraction of all WDs in the photometric footprint of SDSS have been spectroscopically followed up. Using DR7 spectroscopy as a training sample, we developed a method to select high confidence photometric WD candidates. The novelty of our selection is that it allows us to assign to any object with multi-colour and proper motion data a well-defined "probability of being a white dwarf" (or a contaminant). Exploiting this selection method we compiled a catalogue (Gentile Fusillo et al. in prep) which currently covers the entire photometric footprint of SDSS, 14555sq deg, with a limiting magnitude of g ≤ 19. The catalogue contains over 20000 high-confidence WDs and WD candidates 11500 of which have not yet been followed up with Sloan spectroscopy. Even though, so far, our catalogue relies only SDSS we plan to extend the sky coverage as additional deep multi-colour large area surveys become available. DR10 includes over 1.4 million spectra taken with the new BOSS spectrograph, which improves over the original SDSS spectograph in both resolution and wavelength coverage, but has so far not been systematically mined for WD science. As part of this project, we also inspected over 8000 BOSS spectra of bright (g ≤ 19) colour selected sources and classified 1765 new WDs. We used this independent, spectroscopically confirmed sample to further validate our selection method. Finally we discuss possible application of our catalogue , focusing on the selection and follow up of 9 new DZs which show strong pollution from elements other than Ca and IR excess emission emission consistent with the presence of debris discs.

  12. [The American bacteriologist: Dr. Meyer].

    PubMed

    Li, Zheng; Li, Zhi-ping

    2009-01-01

    Karl F. Meyer who was born in Switzerland was American famous bacteriologist of 20th century. During the World War II, Dr. Meyer urged the U. S. military to take positive reply measures against the bacteria war started by Japanese army and achieved significant accomplishments in the preventive and therapeutic theory of plague as well as the manufacture of plague vaccine. After the World War II, Meyer devoted to the scientific field of plague prevention and made great achievements in the area of animal diseases and public health. In 1951, he received the Lasker Award of America.

  13. Interview with Dr. Charley Zeanah

    PubMed Central

    2013-01-01

    Dr. Charles Zeanah is the Mary K. Sellars-Polchow Chair in Psychiatry, Professor of Clinical Pediatrics and Vice Chair for Child and Adolescent Psychiatry in the Department of Psychiatry and Behavioral Sciences at Tulane University School of Medicine in New Orleans. He is also Executive Director of the Institute for Infant and Early Childhood Mental Health at Tulane. He is the recipient of multiple awards including the Irving Phillips Award for Prevention, (AACAP), the Presidential Citation for Distinguished Research and Leadership in Infant Mental Health (American Orthopsychiatric Association), the Sarah Haley Memorial Award for Clinical Excellence (International Society for Traumatic Stress Studies), the Blanche F. Ittelson Award for Research in Child Psychiatry (APA), and the Serge Lebovici Award for International Contributions in Infant Mental Health (World Association for Infant Mental Health). Dr. Zeanah is a Distinguished Fellow of AACAP, a Distinguished Fellow of the APA and a Board Member of Zero to Three. He is the Editor of Handbook of Infant Mental Health (3rd edition) considered as the state of the art textbook and standard reference in the field of Infant Mental Health. PMID:23667354

  14. Dr. von Braun Briefing Walt Disney

    NASA Technical Reports Server (NTRS)

    1965-01-01

    Dr. von Braun began his association with Walt Disney in the 1950s when the rocket scientist appeared in three Disney television productions related to the exploration of space. Years later, Dr. von Braun invited Disney and his associates to tour the Marshall Space Flight Center (MSFC) in Huntsville, Alabama. This photograph is dated April 13, 1965. From left are R.J. Schwinghamer from the MSFC, Disney, B.J. Bernight, and Dr. von Braun.

  15. Dr. Wernher Von Braun greeting dignitaries.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun, left, greets vice president Spiro T. Agnew in the Launch Control Center for the Apollo 14 mission. Between Dr. Von Braun and Mr. Agnew are their Royal Highnesses, The Prince and Princess of Spain. The royal visitors greeted the launch control team in th enter after the launch of Apollo 14.

  16. Dr. Wernher Von Braun at a picnic.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun, director of the Marshall Space Flight Center, stakes claim to a table for the picnic celebrating man's first lunar landing. With Dr. Von Braun are his wife, Maria (seated, right), and son, Peter (back to camera). His daughter, Margrit, was also present, but is hidden from view by friends in this view.

  17. Dr. von Braun Discusses 'Bottle Suit' Concept

    NASA Technical Reports Server (NTRS)

    1954-01-01

    Dr. Wernher von Braun (center), then Chief of the Guided Missile Development Division at Redstone Arsenal, Alabama, discusses a 'bottle suit' model with Dr. Heinz Haber (left), an expert on aviation medicine, and Willey Ley, a science writer on rocketry and space exploration. The three men were at the Disney studios appearing in the motion picture, entitled 'Man in Space.'

  18. An Interview with Dr. Robert W. Young.

    ERIC Educational Resources Information Center

    Silentman, Irene

    1996-01-01

    Dr. Robert W. Young discusses what led him to work in the Navajo Nation and to begin studying Navajo, the method he used for developing a Navajo orthography, his professional relationship with Dr. William Morgan, the system they used to develop an English-Navajo dictionary, his views on language loss, and his greatest accomplishment--a reservation…

  19. Letter to Dr. Felix Bronner

    NASA Technical Reports Server (NTRS)

    Greenleaf, John E.; Dalton, Bonnie (Technical Monitor)

    2002-01-01

    Dear Dr. Bronner: I have been reading in The Physiologist the letters from senior physiologists for many years with great interest. It is impressive that many of the respondents are still pursuing scientific endeavours in their 70's and some even in their 80's. The interesting task is to ponder the relative causative proportions of heredity and environment responsible. One wonders whether knowing something about physiology engenders longer and more productive lives? I suspect so because of the accompanying self-discipline. But another factor would seem to be the pervasive joy of working in this profession. I have been fortunate to be able to acquire the joy of physiology during my graduate studies at Illinois, and to have been able to carry it over here at NASA, Ames Research Center for the past 40 years. A truly academic style research environment at a federal research center is rare. The trick to a joyous research career is to overcome those ever-present slings and arrows of outrageous fortune with dignity whenever possible. To that end I have found solace and guidance in reading the history of warfare and its leaders, especially Sun Tsu's The Art of War and Clauswitz's On War. I became eligible for retirement in 1993, but to insure domestic tranquility and also the joy of pursuing my research hobby have continued working in the laboratory on human research. It is troubling to see that funding for individual scientists conducting human research is declining rapidly, along with their new ideas; perhaps the old ones are more comfortable. Hopefully I can provide a similar response when I'm 80! Thanks for your interest. Sincerely, John Greenleaf

  20. Dr. Robert H. Goddard and His Rockets

    NASA Technical Reports Server (NTRS)

    1926-01-01

    Dr. Robert H. Goddard and liquid oxygen-gasoline rocket in the frame from which it was fired on March 16, 1926, at Auburn, Mass. It flew for only 2.5 seconds, climbed 41 feet, and landed 184 feet away in a cabbage patch. From 1930 to 1941, Dr. Goddard made substantial progress in the development of progressively larger rockets, which attained altitudes of 2400 meters, and refined his equipment for guidance and control, his techniques of welding, and his insulation, pumps, and other associated equipment. In many respects, Dr. Goddard laid the essential foundations of practical rocket technology

  1. Dr. Irvin Yalom Discusses Group Psychotherapy.

    ERIC Educational Resources Information Center

    Forester-Miller, Holly

    1989-01-01

    In this interview, Dr. Irvin Yalom, director of the Adult Psychiatry Clinic at Stanford University School of Medicine, discusses his beginnings as a group psychotherapist, current issues in group work, and the future of group work. (Author/TE)

  2. But Dr. Meisels Is Not Convinced.

    ERIC Educational Resources Information Center

    Meisels, Samuel J.

    1987-01-01

    Commenting on the Gesell Institute's response to his original article concerning the Gesell assessments, Dr. Meisels continues to maintain that the Gesell readiness tests lack sufficient proof of validity. (BB)

  3. Dr. Robert H. Goddard and His Rocket

    NASA Technical Reports Server (NTRS)

    2004-01-01

    Goddard rocket with four rocket motors. This rocket attained an altitude of 200 feet in a flight, November 1936, at Roswell, New Mexico. From 1930 to 1941, Dr. Goddard made substantial progress in the development of progressively larger rockets which attained altitudes of 2400 meters, and refined his equipment for guidance and control, his techniques of welding, and his insulation, pumps, and other associated equipment. In many respects, Dr. Goddard laid the essential foundations of practical rocket technology

  4. Dr. von Braun With German Rocket Experimenters

    NASA Technical Reports Server (NTRS)

    1930-01-01

    Dr. von Braun was among a famous group of rocket experimenters in Germany in the 1930s. This photograph is believed to be made on the occasion of Herman Oberth's Kegelduese liquid rocket engine being certified as to performance during firing. From left to right are R. Nebel, Dr. Ritter, Mr. Baermueller, Kurt Heinish, Herman Oberth, Klaus Riedel, Wernher von Braun, and an unidentified person.

  5. [[The Lactéol's laboratory of Dr Boucard (Laboratoire du Dr Boucard].

    PubMed

    Raynal, Cécile; Lefebvre, Thierry

    2016-03-01

    Shortly before 1910, Dr Boucard creates his laboratory in Paris. It manufactures and sells a drug based on lactic ferments the " Lactéol du Dr Boucard" (Dr's Boucard Lactéol) that will make the fortune of the physician. The article explains Dr Boucard's life and his relationship with the arts (painting and photography), and tells the story of his laboratory until the 2000s, referring to the pharmacists who succeeded them, as well as the various buildings where were elaborated Lactéol's variants. PMID:27281930

  6. Dr. Wernher von Braun and Dr. Ernst Stuhlinger Sign Citizenship Certificates

    NASA Technical Reports Server (NTRS)

    1955-01-01

    The members of the Peenemuende team and their family members were awarded the United States citizenship on April 14, 1955. Pictured here is Dr. Ernst Stuhlinger (middle) and Dr. Wernher von Braun signing U.S. citizenship certificates. Martin Schilling is at left.

  7. Geophysical survey of 105-DR Pluto Crib, 116-DR-4, 100-D Area

    SciTech Connect

    Bergstrom, K.A.

    1993-10-01

    The objective of this Geophysical Survey was to verify the location of the 105-DR Pluto Crib, 116-DR-4. A surface monument currently marks its location. The crib is 10 feet by 10 feet and 15 feet deep. Ground-Penetrating Radar was the geophysical method selected to conduct the investigation.

  8. Dr. Wernher von Braun Laid to Rest

    NASA Technical Reports Server (NTRS)

    1977-01-01

    Dr. Wernher von Braun served as Marshall Space Flight Center's first director from July 1, 1960 until January 27, 1970, when he was appointed NASA Deputy Associate Administrator for Planning. Following World War II, Dr. von Braun and his German colleagues arrived in the United States under Project Paper Clip to continue their rocket development work. In 1950, von Braun and his rocket team were transferred from Ft. Bliss, Texas to Huntsville, Alabama to work for the Army's rocket program at Redstone Arsenal and later, NASA's Marshall Space Flight Center. Under von Braun's leadership, Marshall developed the Saturn V launch vehicle which took Apollo astronauts to the moon. Dr. von Braun died in Alexandria, Va., on June 16, 1977, seven years after his NASA appointment. This photo was taken at the site where he was laid to rest.

  9. DR and CR: Recent advances in technology.

    PubMed

    Schaefer-Prokop, C M; De Boo, D W; Uffmann, M; Prokop, M

    2009-11-01

    After some initial reluctance, nowadays transition from conventional analogue-to-digital radiographic technique is realized in the vast majority of institutions. The eventual triumph of digital over conventional technique is related to its undoubted advantages with respect to image quality and improved image handling in the context of a picture archiving and communication system. CR represents the older system, which matured over decades and experienced some important recent improvements with respect to dose efficiency and work-flow efficiency that strengthened its position. It represents a very versatile, economically attractive system that is equally suited for integrated systems as well as for cassette-based imaging at the bedside. DR systems offer superb image quality and realistic options for dose reduction based on their high dose efficiency. While for a long time only integrated systems were on the market suited for a large patient throughput, also mobile DR systems became recently available. While for the next years, it is likely that DR and CR systems will coexist, the long term perspective of CR will depend on further innovations with respect to dose efficiency and signal-to-noise characteristics while for DR economical aspects and broader availability of mobile systems will play a role. PMID:19695809

  10. Dr. Akira Tonomura: Master of Experimental Physics

    NASA Astrophysics Data System (ADS)

    Fujikawa, Kazuo

    2014-01-01

    Dr. Akira Tonomura, Hitachi Fellow, passed away on May 2, 2012 at the age of 70. As a classmate at the University of Tokyo and his long-time friend, I would like to describe my personal memory of Tonomura and a brief review of his contributions to fundamental physics.

  11. Dr. von Braun Visits Huntsville Boys Club

    NASA Technical Reports Server (NTRS)

    1961-01-01

    Dr. von Braun, Director of Marshall Space Flight Center (MSFC) and chairman of this year's United Givers Fund (UGF) drive at MSFC, takes time out from the problems of sending a man to the Moon to talk baseball with 11-year-old Randy Smith at the Huntsville Boys Club.

  12. Dr. Wernher Von Braun presents a certificate

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun (left), director of the Marshall Space Flight Center, presents a humorous certificate to Major General Charles W. Eifler, commanding general of Redstone Arsenal, at the close of a farewell luncheon for the general prior to General Eifler moving to a new European duty station.

  13. Walt Disney and Dr. Wernher von Braun

    NASA Technical Reports Server (NTRS)

    1954-01-01

    Dr. Werhner von Braun, then Chief, Guided Missile Development Operation Division at Army Ballistic Missile Agency (ABMA) in Redstone Arsenal, Alabama, was visited by Walt Disney in 1954. In the 1950's, von Braun worked with Disney Studio as a technical director, making three films about space exploration for television. A model of the V-2 rocket is in background.

  14. ["Allergy testing" with "Dr. Voll electroacupuncture"].

    PubMed

    Bresser, H

    1993-06-01

    Electroacupuncture according to Dr. Voll (EAV) is one of the numerous unconventional methods propagated for allergy testing in Germany. From an experimental examination for "drug testing" of this method, it can be concluded that EAV is unsuitable for any form of allergy testing.

  15. An Interview with Dr. Deborah W. Proctor

    ERIC Educational Resources Information Center

    Landsberger, Joe

    2007-01-01

    In an interview, Dr. Deborah W. Proctor, eCurriculum Director for Academic Innovations/ Minnesota Online and Co-Chair for the MERLOT International Conference, outlines her academic path that led to her current position and interests. As e-Curriculum Director for Academic Innovations in the Office of the Chancellor she works with system…

  16. Interview [with Dr. Gerald W. Bracey

    ERIC Educational Resources Information Center

    Journal of Educational Research, 2007

    2007-01-01

    This article presents an interview with Dr. Gerald W. Bracey, author of "Reading Educational Research: How to Avoid Getting Statistically Snookered." During the interview, Bracey explains why he considers the No Child Left Behind Act (NCLB) as a "weapon of mass destruction" and that he sees nothing to suggest that NCLB has improved schools.…

  17. ORAC-DR: Astronomy data reduction pipeline

    NASA Astrophysics Data System (ADS)

    Jenness, Tim; Economou, Frossie; Cavanagh, Brad; Currie, Malcolm J.; Gibb, Andy

    2013-10-01

    ORAC-DR is a generic data reduction pipeline infrastructure; it includes specific data processing recipes for a number of instruments. It is used at the James Clerk Maxwell Telescope, United Kingdom Infrared Telescope, AAT, and LCOGT. This pipeline runs at the JCMT Science Archive hosted by CADC to generate near-publication quality data products; the code has been in use since 1998.

  18. A TRIBUTE TO DR. WILLIAM PENN WATKINSON

    EPA Science Inventory

    Dr. William Penn Watkinson (known to colleagues as "Penn") of EPA¿s health research lab (National Health and Environmental Research Laboratory) of Research Triangle Park, North Carolina, died Wednesday, December 13 after a battle with lung cancer. He was a member of the Pulmonar...

  19. Dr. Caleb Williams Saleeby: The Complete Eugenicist.

    ERIC Educational Resources Information Center

    Rodwell, Grant

    1997-01-01

    Profiles the work of Dr. Caleb Williams Saleeby, a late 19th-century propagandist for eugenics. Eugenics is a science that deals with the transmission of hereditary racial traits, coupled with a desire to use this for the elimination of social ills. Discusses Saleeby's work with the Eugenics Education Society. (MJP)

  20. Dr. Israel Cuellar (1946-2008)

    ERIC Educational Resources Information Center

    Zamarripa, Manuel X.

    2009-01-01

    On September 7th, 2008, the mental health field lost a trailblazing researcher and clinician as he lost his battle with amyotrophic lateral sclerosis (ALS), commonly referred to as Lou Gehrig's disease. Dr. Israel Cuellar made significant contributions to the study of acculturation including its importance in delivering appropriate mental health…

  1. Dr. von Braun and Dr. Stuhlinger With a Model of the Nuclear-Electric Vehicles

    NASA Technical Reports Server (NTRS)

    2004-01-01

    In this photo, taken at the Walt Disney Studios in California, Dr. Wernher von Braun and Dr. Ernst Stuhlinger are shown discussing the concepts of nuclear-electric spaceships designed to undertake the mission to the planet Mars. As a part of the Disney 'Tomorrowland' series on the exploration of space, the nuclear-electric vehicles were shown in the last three television films, entitled 'Mars and Beyond,' which first aired in December 1957.

  2. Global collapse of the DR21 filament

    NASA Astrophysics Data System (ADS)

    Schneider, N.; Csengeri, T.; Bontemps, S.; Motte, F.; Simon, R.; Hennebelle, P.; Federrath, C.; Klessen, R.

    2011-05-01

    The formation of massive stars is a highly complex process in which it is unclear whether the star-forming gas is in global gravitational collapse or an equilibrium state supported by turbulence and/or magnetic fields. By studying the most massive and dense star-forming clump in the Galaxy at a distance of less than 3 kpc, i.e. the filament containing DR21 and DR21(OH), we obtained observational evidence to help us to discriminate between these two views. For that, we used molecular line data from our 13CO 1→0, CS 2→1, and N_2H^+ 1→0 survey of the Cygnus X region (FCRAO) and high-angular resolution observations in isotopomeric lines of CO, CS, HCO^+, N_2H^+, and H_2CO, obtained with the IRAM 30m telescope. The observations reveal a complex velocity field and velocity dispersion in which regions of the highest column-density, i.e. dense cores, have a lower velocity dispersion than the surrounding gas and velocity gradients that are not (only) due to rotation. Infall signatures in optically thick line profiles of HCO^+ and 12CO are observed along and across the whole DR21 filament. By modelling the observed spectra, we obtain a typical infall speed of ˜0.6 km s-1 and mass accretion rates of the order of a few 10-3 M_⊙ yr-1 for the two main clumps constituting the filament. These massive clumps (4900 and 3300 M_⊙ at densities of around 10^5 cm-3 within 1 pc diameter) are both gravitationally contracting (with free-fall times much shorter than sound crossing times and low virial parameter α). The more massive of the clumps, DR21(OH), is connected to a sub-filament, apparently 'falling' onto the clump. This filament runs parallel to the magnetic field. All observed kinematic features in the DR21 filament (velocity field, velocity dispersion, and infall), its filamentary morphology, and the existence of (a) sub-filament(s) can be explained if the DR21 filament was formed by the convergence of flows on large scales and is now in a state of global gravitational

  3. Centennial Presidential Perspective: Dr. Alfred Blalock

    PubMed Central

    Beaty, Claude A.; George, Timothy J.; Conte, John V.

    2014-01-01

    Great men are not a common occurrence. Indeed, they are a rare find. Though respected and lauded in their time, it is only in retrospect that their true contributions can be adequately measured as a surgeon, an educator and a scientist. Such is the case of Dr. Alfred Blalock. Many have considered him the father of modern cardiac surgery. All consider his “blue baby” operation to be one of the landmarks of cardiac surgery and, as the chief of surgery at Johns Hopkins, he trained many who would become the leaders of our discipline. His continual reach for excellence helped him to not only affect, but revolutionize the paradigm of surgical research, an understanding of the physiology of shock and the surgical management of pulmonic stenosis/atresia. Dr. Blalock was the 30th president of the American Association for Thoracic Surgery and his presidential address was given in 1951. PMID:22248679

  4. Introduction of Dr. Andrew V Schally

    PubMed Central

    Mendoza-Valdés, Arturo

    2015-01-01

    I first met Dr. Andrew V Schally (PhD, MDhc (Multi), DSc, Distinguished Medical Research Scientist, U.S. Department of Veterans Affairs Professor of Pathology and Department of Medicine,
Miller School of Medicine, University of Miami, Miami, Florida, USA) many years ago, probably around the beginning of the 1990's in one of his visits to Mexico City (Figure 1). He has many friends in my country since some of the investigations that led to the development of the LHRH agonists were made in a couple of Mexican hospitals in collaboration with some outstanding Mexican physicians that I will mention later. In that time, I was the head of the Department of Urology of the Mexican National Cancer Institute and our Director, Dr. Jaime de la Garza, invited him for a meeting. I was surprised by his humbleness, intelligence and easy going personality, in spite of being a Nobel Prize scientist. PMID:26112485

  5. Dr. Wernher von Braun In His Office

    NASA Technical Reports Server (NTRS)

    1964-01-01

    Dr. Wernher von Braun served as Marshall Space Flight Center's first director from July 1, 1960 until January 27, 1970, when he was appointed NASA Deputy Associate Administrator for Planning. Following World War II, Dr. von Braun and his German colleagues arrived in the United States under Project Paperclip to continue their rocket development work. In 1950, von Braun and his rocket team were transferred from Ft. Bliss, Texas to Huntsville, Alabama to work for the Army's rocket program at Redstone Arsenal and later, NASA's Marshall Space Flight Center. Under von Braun's leadership, Marshall developed the Saturn V launch vehicle which took Apollo astronauts to the moon. This photo depicts von Braun in his office at MSFC.

  6. Dr.L: Distributed Recursive (Graph) Layout

    2007-11-19

    Dr. L provides two-dimensional visualizations of very large abstract graph structures. it can be used for data mining applications including biology, scientific literature, and social network analysis. Dr. L is a graph layout program that uses a multilevel force-directed algorithm. A graph is input and drawn using a force-directed algorithm based on simulated annealing. The resulting layout is clustered using a single link algorithm. This clustering is used to produce a coarsened graph (fewer nodes)more » which is then re-drawn. this process is repeated until a sufficiently small graph is produced. The smallest graph is drawn and then used as a basis for drawing the original graph by refining the series of coarsened graphs that were produced. The layout engine can be run in serial or in parallel.« less

  7. Dr. Wernher Von Braun examines a ruby crystal.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun (right), director of the Marshall Space Flight Center, and Dr. Eberhard Rees (left), deputy director, technical, examine a ruby crystal used in laser experiments in the Marshall Center's Space Sciences Laboratory.

  8. [Homage to Professor Dr. Nicasio Etchepareborda].

    PubMed

    1998-11-01

    During a solemn academic act, de Main Classroom of the Facultad de Odontologia de Buenos Aires was named after Prof. Dr. Nicasio Etchepareborda. He has been the first professor at the Escuela de Odontologia and its organizer, after having obtained his Dentistry degree at the Dental School of Paris, in 1882. The new school was founded in 1891, and its activities began the following year.

  9. 1895: Dr W G Grace's golden summer.

    PubMed Central

    Toghill, P.

    1995-01-01

    One hundred years ago there was another wonderful summer. Dr. W G Grace, England's greatest cricketer, in his 47th year, completed his "century of centuries" and scored 2346 runs. This remarkable achievement was celebrated with enthusiasm and affection by the Victorian public. In more practical terms generous testimonials raised 9073 pound sterling 8s 6d, which made it a golden summer in more ways than one. Images p618-a PMID:7663257

  10. Dr Amos G Babcock - fact or fiction?

    PubMed

    Smith, Douglas

    2014-11-01

    The War of 1812-14 between the United States of America and Great Britain gave rise to several journals relating the sufferings of prisoners of war confined in prison ships and gaols in England. One of these is A Journal of a Young Man from Massachusetts, said to have been written by Dr Amos G Babcock, an American ship's surgeon, and first published in 1816. This article sets out arguments for and against the truth of this assertion.

  11. Working with Dr. Per V. Bruel

    NASA Astrophysics Data System (ADS)

    Gade Kjaer, Svend

    2002-11-01

    For more than a decade I have had the pleasure to work as an application specialist together with--and for--Dr. Bruel, one of the founders of the Bruel & Kjaer Company, famous for sound and vibration measurement instrumentation, often nicknamed ''Green Boxes.'' It has been a great experience for me, and I recall this period in my life as one where I was much inspired by Dr. Bruel's methods, both as a private person and with his work as a director for the company and leader of both the sales and the innovation departments. In this presentation I will highlight some funny stories that are told about Dr. Bruel combined with the episodes that I have experienced myself. In short, the most simple way to characterize this rather complex person is maybe by repeating his vision statement for the company: ''We shall have fun and we shall make money. On the other hand we shall not have so much fun that we do not make any money, and we shall not make so much money that we do not have any fun!'' For Per Bruel, acoustics is one of his great hobbies. He has others such as cars, airplanes, motorbikes (he is the lucky owner of a Danish Nimbus) and wine.

  12. Dr. Wernher Von Braun talkes with George Hardy.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    George Hardy of the Marshall Space Flight center's Astronautics Laboratory, talks with Dr. Wernher Von Braun (right), deputy associate administrator for planning. Dr. Von Braun was inspecting the mockup of the Saturn workshop during a visit to the Marshall Center. The visit coincided with the 10th anniversary celebration of the center of which Dr. Von Braun was director until March 1, 1970.

  13. Interview with Dr Joseph Murray (by Francis L Delmonico).

    PubMed

    Murray, Joseph

    2002-10-01

    The Editors asked Dr Delmonico to interview Dr Joseph Murray, winner of the Nobel prize in Medicine 1990 for performing the first successful renal transplant, to record recollections of the issues of the 1950s, when clinical transplantation was born, on Dr Murray's medical career in transplantation, and on some contemporary issues.

  14. DR JOHN ADAMCZYK AND DR LONNIE REID EXAMINE SOFTWARE FOR THE NEW START-UP SOFTWARE - ELECTRONICS - A

    NASA Technical Reports Server (NTRS)

    1999-01-01

    DR JOHN ADAMCZYK AND DR LONNIE REID EXAMINE SOFTWARE FOR THE NEW START-UP SOFTWARE - ELECTRONICS - AND COMMUNICATIONS - SEC - INCUBATOR OPENED MAY 1 1999 AS PART OF THE LEWIS INCUBATOR FOR TECHNOLOGY - LIFT

  15. HLA-DR alleles determine responsiveness to Borrelia burgdoferi antigens

    PubMed Central

    Iliopoulou, Bettina Panagiota; Guerau-de-Arellano, Mireia; Huber, Brigitte T.

    2010-01-01

    Objective Arthritis is a prominent manifestation of Lyme disease, caused upon infection with Borrelia burgdorferi (Bb). Persistent chronic Lyme arthritis, even after antibiotic treatment, is linked to HLA-DRB1*0401 (DR4) and related alleles. On the contrary, Lyme patients who resolve arthritis within 3 months post-infection show an increased frequency of HLA-DRB1*1101 (DR11). The aim of this study was to analyze the underlying mechanism by which HLA-DR alleles confer genetic susceptibility or resistance to antibiotic-refractory Lyme arthritis. Methods We generated DR11 transgenic (tg) mice on a murine class II−/− background and compared their immune response to Bb-antigens to that of DR4 tg mice after immunization with Bb outer surface protein (Osp)A or infection with live Bb. Results We report that the T cells of OspA-immunized and Bb-infected DR11 tg mice were defective in IFN-γ production compared to those of DR4 mice. On the other hand, DR11 tg mice developed higher titers of anti-OspA and anti-Bb Abs, respectively, than DR4 mice. In accordance with this observation, we found that Bb-infected DR11 tg mice had decreased spirochetal burden compared to DR4 mice, measured by qPCR. Conclusion This study provides direct evidence that in the presence of HLA-DR11 the immune response against Bb-antigens is directed towards a protective Ab response. In contrast, an inflammatory Th1 response is induced in the presence of DR4. These observations offer an explanation for the differential genetic susceptibility of DR4+ and DR11+ individuals for the development of chronic Lyme arthritis and eventually the progression to antibiotic-refractory Lyme arthritis. PMID:19950279

  16. Multiwavelength observations of two B-star nurseries - DR 15 and DR 20

    SciTech Connect

    Odenwald, S.F.; Campbell, M.F.; Shivanandan, K.; Schwartz, P.; Fazio, G.G.; Moseley, H. Colby College, Waterville, ME Naval Research Laboratory, Washington, DC Harvard-Smithsonian Center for Astrophysics, Cambridge, MA NASA, Goddard Space Flight Center, Greenbelt, MD )

    1990-01-01

    New observations of DR 15 and 20 are reported as part of a study of compact H II regions in the Cyg X region. The radio and FIR data for these objects, when combined with (C-12)O maps, IRAS imagery, and optical photographs, provide new insights into the structure of this complex region and the nature of the star-formation process there. The observations show that DR 15 may consist of one or two B0 ZAMS stars whose H I regions have formed a low-density cavity within a molecular cloud. DR 20 appears to be a young OB cluster. The cluster is dominated by an O5.5 ZAMS star and also contains an approximately 3500-yr-old B0 star appearing as a compact H II region, along with weak FIR sources that may be B0-star candidates. 36 refs.

  17. On the trail of Dr. Fifer.

    PubMed Central

    Asche, G

    1996-01-01

    A gift from a patient drew Hope, BC, family physician Gerd Asche irrevocably into the local medical history of the 1858 Fraser River Gold Rush. Because of his interest in Dr. Max William Fifer, Asche undertook research missions in British Columbia, England and the US, converted his computer room to a research and writing centre, and wrote a biography of his predecessor and colleague. He recounts his experience and the growing satisfaction provided by his interest in medical history. Images p1398-a PMID:8616743

  18. Singultus foetalis and Dr. Alfons Mermann.

    PubMed

    Miller, Christopher C; Petroianu, Georg A

    2016-01-01

    During intrauterine life, hiccups are universally present, their incidence peaking in the third trimester. Alfons Mermann (1852-1908), a gynecologist from Mannheim, Germany, best known for having established the Luisenheim Woechnerinnenasyl [lying-in asylum] there in 1887, is viewed as the first physician to name and describe singultus foetalis [fetal hiccups] in a modern peer-reviewed scientific publication. This short report attempts to shed some light on the work of Dr. Mermann and to explore whether or not he was indeed the first to recognize this phenomenon. PMID:26529591

  19. Dr. Jan Rogers with Electrostatic Levitator

    NASA Technical Reports Server (NTRS)

    1998-01-01

    Dr. Jan Rogers, project scientist for the Electrostatic Levitator (ESL) at NASA's Marshall Space Flight Center(MSFC). The ESL uses static electricity to suspend an obejct (about 2-3 mm in diameter) inside a vacuum chamber while a laser heats the sample until it melts. This lets scientists record a wide range of physical properties without the sample contacting the container or any instruments, conditions that would alter the readings. The Electrostatic Levitator is one of several tools used in NASA's microgravity materials sciences program.

  20. White dwarfs identified in LAMOST DR 2

    NASA Astrophysics Data System (ADS)

    Guo, Jincheng; Zhao, Jingkun; Tziamtzis, Anestis; Liu, Jifeng; Li, Lifang; Zhang, Yong; Hou, Yonghui; Wang, Yuefei

    2015-12-01

    Here we present a catalogue of 1056 spectroscopically identified hydrogen-dominated white dwarfs (DAWDs), 34 helium-dominated white dwarfs (DBWDs) and 276 white dwarf main sequence (WDMS) binaries from the Large sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST) survey data release 2 (DR2). 383 DAWDs, 4 DBWDs and 138 WDMSs are new identifications after cross-match with literature. There are ˜4100 k spectra in total from DR 2. The low ratio of white dwarfs found in LAMOST is attributed to biased selection of LAMOST input catalogue and much brighter targets relative to stars observed in Sloan Digital Sky Survey. In this paper, a new DAWD selection method is adopted as a new attempt and supplement to the traditional methods. The effective temperature, surface gravity, mass, cooling age and distance of high signal-to-noise DAWDs are estimated. The peak of the mass distribution is found to be ˜0.6 M⊙, which is consistent with previous work. The parameters of WDMS binaries are also provided in this paper. As the foundation of our future work, which is to identify more WDs with debris disc, WDs found in LAMOST showed a lot of potential. Interesting infrared-excess WDs will be reported in our forthcoming paper.

  1. Enrico Fermi Awards Ceremony for Dr. Mildred S. Dresselhaus and Dr. Burton Richter, May 2012 (Presentations, including remarks by Energy Secretary, Dr. Steven Chu)

    SciTech Connect

    Chu, Steven

    2012-05-07

    The Fermi Award is a Presidential award and is one of the oldest and most prestigious science and technology honors bestowed by the U.S. Government. On May 7, 2012 it was conferred upon two exceptional scientists: Dr. Mildred Dresselhaus, 'for her scientific leadership, her major contributions to science and energy policy, her selfless work in science education and the advancement of diversity in the scientific workplace, and her highly original and impactful research,' and Dr. Burton Richter, 'for the breadth of his influence in the multiple disciplines of accelerator physics and particle physics, his profound scientific discoveries, his visionary leadership as SLAC Director, his leadership of science, and his notable contributions in energy and public policy.' Dr. John Holder, Director of the White House Office of Science and Technology Policy, opened the ceremony, and Dr. Bill Brinkman, Director of DOE's Office of Science introduced the main speaker, Dr. Steven Chu, U.S. Energy Secretary.

  2. Enrico Fermi Awards Ceremony for Dr. Mildred S. Dresselhaus and Dr. Burton Richter, May 2012 (Presentations, including remarks by Energy Secretary, Dr. Steven Chu)

    ScienceCinema

    Chu, Steven (U.S. Energy Secretary)

    2016-07-12

    The Fermi Award is a Presidential award and is one of the oldest and most prestigious science and technology honors bestowed by the U.S. Government. On May 7, 2012 it was conferred upon two exceptional scientists: Dr. Mildred Dresselhaus, 'for her scientific leadership, her major contributions to science and energy policy, her selfless work in science education and the advancement of diversity in the scientific workplace, and her highly original and impactful research,' and Dr. Burton Richter, 'for the breadth of his influence in the multiple disciplines of accelerator physics and particle physics, his profound scientific discoveries, his visionary leadership as SLAC Director, his leadership of science, and his notable contributions in energy and public policy.' Dr. John Holder, Director of the White House Office of Science and Technology Policy, opened the ceremony, and Dr. Bill Brinkman, Director of DOE's Office of Science introduced the main speaker, Dr. Steven Chu, U.S. Energy Secretary.

  3. [Dr. John Baptiste Edouard Gélineau].

    PubMed

    Janković, S; Susić, V; Sokić, D; Lević, Z

    1996-01-01

    With this brief review we honor the memory of the great French doctor Jean Baptiste Edouard Gélineau. Dr. Gélineau was born on December 23, 1828 at Blaye, Gironde, close to the Bordeaux region. His name is connected with the first clinical description of the disease for which he, both by the right of the primacy as well as ad valorem of his first two names, coined the name "narcolepsy". He was the first to notice the intrinsically evanescent symptoms of narcolepsy, such as excessive daytime somnolence, imperative sleep habits and cataplexy or "astasia" as he called it, and incorporate them into a single clinical syndrome. In 1881 Gélineau discussed Kaffe's case of "maladie du sommeil" as a proof of the existence of the new disease described a year before. As a good clinical observer Gélineau noticed the close relation of emotional engagement and astasia. His attitude was that narcolepsy was a nosologic entity, a disease sui generis, but admitted that it could appear purely as a symptom only. This was in discordance with the views in England where (in 1928) Dr. Samuel Alexander Kinnier Wilson repudiated such convictions; in 1930 Lhermitte still shared the same opinion. Gélineau differentiated narcolepsy from epilepsy with the elegance of clinical reasoning. Overall, Gélineau described three elements of the narcoleptic pentade. Sleep paralyses were first described by Mitchell in 1876, and were first attributed to narcolepsy by Wilson in 1928; in 1930 Lhermitte first described hypnapompic, and Daniels, in 1934, hypnagogic sleep paralysis. Hypnagogic hallucinations were described by Maury in 1848 and subsequently by de Saint Denis in 1867. In twenties they were thoroughly studiesed during the epidemic encephalitis and after the Big War in 1922 by Levy. The life story of Dr. Gélineau covers multivarious activities. As a young student of the Rochefort Navy Medical School he took part in the fight against colera which deluged the city of La Rochelle. In 1849 he

  4. [Dr. Hideyo Noguchi and Hajime Hoshi].

    PubMed

    Misawa, M

    1991-01-01

    Hajime Hoshi is a founder of Hoshi Pharmaceutical Company and of Hoshi University. He became acquainted with Dr. Hideyo Noguchi in the United States in 1901 during his study abroad. Hoshi often stayed overnight at Noguchi's apartment in Philadelphia. Hoshi and Noguchi were both from Fukushima, Japan, and Hoshi was three years older than Noguchi. Both persons had been good friends until Hoguchi died in 1928. Hoshi and Noguchi together had met Hirobumo Ito and Thomas Edison. In 1906, Hoshi came back to Japan after a 12-year stay in the United States. The financial support by Hoshi enabled the only and one temporary returning of Noguchi to Japan in 1915. In this paper, the friendship between the famous two persons is described in detail.

  5. [Dr. Hideyo Noguchi and Hajime Hoshi].

    PubMed

    Misawa, M

    1991-01-01

    Hajime Hoshi is a founder of Hoshi Pharmaceutical Company and of Hoshi University. He became acquainted with Dr. Hideyo Noguchi in the United States in 1901 during his study abroad. Hoshi often stayed overnight at Noguchi's apartment in Philadelphia. Hoshi and Noguchi were both from Fukushima, Japan, and Hoshi was three years older than Noguchi. Both persons had been good friends until Hoguchi died in 1928. Hoshi and Noguchi together had met Hirobumo Ito and Thomas Edison. In 1906, Hoshi came back to Japan after a 12-year stay in the United States. The financial support by Hoshi enabled the only and one temporary returning of Noguchi to Japan in 1915. In this paper, the friendship between the famous two persons is described in detail. PMID:11623302

  6. Dr. Cheryl Nickerson studies Salmonella Typhimurium

    NASA Technical Reports Server (NTRS)

    2003-01-01

    Dr. Cheryl Nickerson of Tulane University is studying the effects of simulated low-g on a well-known pathogen, Salmonella typhimurium, a bacterium that causes two to four million cases of gastrointestinal illness in the United States each year. While most healthy people recover readily, S. typhimurium can kill people with weakened immune systems. Thus, a simple case of food poisoning could disrupt a space mission. Using the NASA rotating-wall bioreactor, Nickerson cultured S. typhimurium in modeled microgravity. Mice infected with the bacterium died an average of three days faster than the control mice, indicating that S. typhimurium's virulence was enhanced by the bioreactor. Earlier research showed that 3 percent of the genes were altered by exposure to the bioreactor. Nickerson's work earned her a 2001 Presidential Early Career Award for Scientists and Engineers.

  7. Entrevue avec le Dr Charley Zeanah

    PubMed Central

    2013-01-01

    Le Dr Charles Zeanah est titulaire de la chaire de psychiatrie Mary K. Sellars-Polchow, professeur de pédiatrie clinique et vice-président de la pédopsychiatrie au département de psychiatrie et des sciences du comportement de la faculté de médecine de l’Université Tulane, à la Nouvelle-Orléans. Il est également directeur général de l’institut de la santé mentale des nourrissons et des jeunes enfants de Tulane. Il est récipiendaire de nombreux prix, notamment le prix de prévention Irving Phillips (AACAP), la mention élogieuse présidentielle pour sa recherche et son leadership exceptionnels en santé mentale des nourrissons (American Orthopsychiatric Association), le prix d’excellence clinique Sarah Haley Memorial (International Society for Traumatic Stress Studies), le prix de recherche en pédopsychiatrie Blanche F. Ittelson (APA), et le prix Serge Lebovici Award soulignant les contributions internationales à la santé mentale des nourrissons (World Association for Infant Mental Health). Le Dr Zeanah est fellow distingué de l’AACAP, fellow distingué de l’APA et membre du conseil d’administration de Zero to Three. Il est l’éditeur scientifique de Handbook of Infant Mental Health (3e édition) qui est considéré comme étant le manuel de pointe et la référence de base du domaine de la santé mentale des nourrissons.

  8. Goldie Brangman Remembers the Operation to Save Dr King.

    PubMed

    Koch, Evan; Brangman, Goldie

    2015-12-01

    In September 1958 the Rev Dr Martin Luther King Jr was stabbed and nearly assassinated. Surgeons at Harlem Hospital in New York City removed a 17.8-cm (7-in)-long letter opener from Dr King's chest. Certified Registered Nurse Anesthetist Goldie Brangman remembers this event because she participated in Dr King's anesthetic. This article correlates Brangman's memories with published accounts of the event. It also places the event within the context of the modern civil rights movement that Dr King led. PMID:26742331

  9. Goldie Brangman Remembers the Operation to Save Dr King.

    PubMed

    Koch, Evan; Brangman, Goldie

    2015-12-01

    In September 1958 the Rev Dr Martin Luther King Jr was stabbed and nearly assassinated. Surgeons at Harlem Hospital in New York City removed a 17.8-cm (7-in)-long letter opener from Dr King's chest. Certified Registered Nurse Anesthetist Goldie Brangman remembers this event because she participated in Dr King's anesthetic. This article correlates Brangman's memories with published accounts of the event. It also places the event within the context of the modern civil rights movement that Dr King led.

  10. The DraC usher in Dr fimbriae biogenesis of uropathogenic E. coli Dr(+) strains.

    PubMed

    Zalewska-Piatek, Beata; Kur, Marta; Wilkanowicz, Sabina; Piatek, Rafał; Kur, Józef

    2010-05-01

    Biogenesis of Dr fimbriae encoded by the dra gene cluster of uropathogenic Escherichia coli strains requires the chaperone-usher pathway. This secretion system is based on two non-structural assembly components, the DraB periplasmic chaperone and DraC outer-membrane usher. The DraB controls the folding of DraE subunits, and DraC forms the assembly and secretion platform for polymerization of subunits in linear fibers. In this study, mutagenesis of the DraC N-terminus was undertaken to select residues critical for Dr fimbriae bioassembly. The DraC-F4A, DraC-C64, DraC-C100A and DraC-W142A significantly reduced the adhesive ability of E. coli strains. The biological activity of the DraC mutants as a assembly platform for Dr fimbriae polymerization was verified by agglutination of human erythrocytes and adhesion to DAF localized at the surface of CHO-DAF(+) and HeLa cells. The residue F4 of the DraC usher conserved among FGL and FGS chaperone-assembled adhesive organelles can be used to design pillicides blocking the biogenesis of Dr fimbriae. Because the draC and afaC-III genes share 100% identity the range of the virulence determinant inhibitors could also be extended to E. coli strains encoding afa-3 gene cluster. The investigations performed showed that the usher N-terminus plays an important role in biogenesis of complete fiber.

  11. Enrico Fermi Awards Ceremony for Dr. Allen J. Bard and Dr. Andrew Sessler, February 2014 (Presentations, including remarks by Energy Secretary, Dr. Ernest Moniz)

    ScienceCinema

    Moniz, Ernest [U.S. Energy Secretary

    2016-07-12

    The Fermi Award is a Presidential award and is one of the oldest and most prestigious science and technology honors bestowed by the U.S. Government. On February 3, 2014 it was conferred upon two exceptional scientists. The first to be recognized is Dr. Allen J. Bard, 'for international leadership in electrochemical science and technology, for advances in photoelectrochemistry and photocatalytic materials, processes, and devices, and for discovery and development of electrochemical methods including electrogenerated chemiluminescence and scanning electrochemical microscopy.' The other honoree is Dr. Andrew Sessler, 'for advancing accelerators as powerful tools of scientific discovery, for visionary direction of the research enterprise focused on challenges in energy and the environment, and for championing outreach and freedom of scientific inquiry worldwide.' Dr. Patricia Dehmer opened the ceremony, and Dr. Ernest Moniz presented the awards.

  12. Enrico Fermi Awards Ceremony for Dr. Allen J. Bard and Dr. Andrew Sessler, February 2014 (Presentations, including remarks by Energy Secretary, Dr. Ernest Moniz)

    SciTech Connect

    Moniz, Ernest

    2014-02-03

    The Fermi Award is a Presidential award and is one of the oldest and most prestigious science and technology honors bestowed by the U.S. Government. On February 3, 2014 it was conferred upon two exceptional scientists. The first to be recognized is Dr. Allen J. Bard, 'for international leadership in electrochemical science and technology, for advances in photoelectrochemistry and photocatalytic materials, processes, and devices, and for discovery and development of electrochemical methods including electrogenerated chemiluminescence and scanning electrochemical microscopy.' The other honoree is Dr. Andrew Sessler, 'for advancing accelerators as powerful tools of scientific discovery, for visionary direction of the research enterprise focused on challenges in energy and the environment, and for championing outreach and freedom of scientific inquiry worldwide.' Dr. Patricia Dehmer opened the ceremony, and Dr. Ernest Moniz presented the awards.

  13. Reexamining the Writings of Dr. Seuss To Promote Character Development.

    ERIC Educational Resources Information Center

    Brown, Dave F.; Varady, Joe

    1997-01-01

    Discusses the use of children's literature by Dr. Seuss in the middle school classroom to help students explore issues of their character and social development, adult expectations, and changes in their personal environment. Discusses themes addressed in selected Dr. Seuss books, and how these can be used as thematic units for classroom…

  14. Dr. Wernher Von Braun near the mobile launcher.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. George Mueller, NASA associate administrator for manned space flight, and Dr. Wernher Von Braun (right), director of the Marshall Space Flight Center, are seen near the mobile launcher carrying a 363 foot tall Saturn V space launch vehicle as the rocket is rolled from the vehicle assembly building at KSC for its three mile trip to the launch pad.

  15. Dr. Albert Carr--Science Educator 1930-2000

    ERIC Educational Resources Information Center

    Lopez, Leslie

    2013-01-01

    The very first issue of "Educational Perspectives" was published in October of 1962. Dr. Albert Carr wrote one of the inaugural essays on the topic of current developments in science education, and he went on to write several other articles for the journal. This article shares why Dr. Albert Carr's colleagues remember him for his…

  16. Biotechnology Symposium - In Memoriam, the Late Dr. Allan Zipf

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A one-day biotechnology symposium was held at Alabama A&M University (AAMU), Normal, AL on June 4, 2004 in memory of the late Dr. Allan Zipf (Sept 1953-Jan 2004). Dr. Zipf was a Research Associate Professor at the Department of Plant and Soil Sciences, AAMU, who collaborated extensively with ARS/MS...

  17. Dr. Shawn Mehlenbacher 2012 Wilder Silver Medal Recipient

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Dr. Shawn Mehlenbacher, Oregon State University, was awarded the 2012 Wilder Medal by the American Pomological Society for his contributions to hazelnut genetics and cultivar development. Dr. Mehlenbacher took over the leadership of the Oregon State University hazelnut breeding program in 1986 aft...

  18. Celebrating the Life and Legacy of Dr. John Hope Franklin

    ERIC Educational Resources Information Center

    Harris, Robert L., Jr.; Levering-Lewis, David; French, John D.; Wharton, Clifton R., Jr.

    2009-01-01

    Dr. John Hope Franklin chronicled the experiences of African-Americans like no one before him, forcing America to recognize Black history as American history. His contributions were innumerable and his impact was abiding. In celebration of his life and legacy, the authors profile the celebrated scholar and activist, Dr. John Hope Franklin.

  19. Dr. Irene Sänger-Bredt, a life for astronautics

    NASA Astrophysics Data System (ADS)

    Zaganescu, Nicolae-Florin

    2004-12-01

    Irene Bredt (b.1911 at Bonn) obtained her Doctorate in Physics in 1937; in the same year she became a scientific researcher at the German Research Center for Aviation at Trauen, led by Prof. Dr. Eugen Sänger. Soon, the young but efficient Dr. Irene Bredt became the first assistant of Dr. Sänger, who married her (1951). During 1973-1978, Dr. Bredt was in correspondence with Prof. Dr. Nikolae-Florin Zaganescu and helped him to familiarize the Romanian readers with Prof. Sänger's life and achievements. As for Dr. Bredt's life, she specified three main periods of her activity: 1937-1942, when she was researcher in charge of thermodynamic problems of liquid-fuelled rocket engines at Trauen 1942-1945, when she was Senior Researcher in charge of Ramjet in flight performances at Ainring, and also coauthored the Top Secret Technical report entitled 'A Rocket Engine for a Long-Range Bomber', which was finished in 1941 but edited only in 1944 the post world war II period, when she was Scientific Advisor or Director at various civil and military research institutes, universities, etc. Dr. Irene Sänger-Bredt helped her husband to develop many scientific theories like Ramjet thermodynamic theory, and photon rocket theory and also in establishing IAF and IAA. In 1970, Dr. Irene Sänger-Bredt was honored with 'Hermann Oberth Gold Medal' for her impressive scientific activity.

  20. The 1850 Webster/Parkman Trial: Dr. Keep's forensic evidence.

    PubMed

    Christen, Arden G; Christen, Joan A

    2003-03-01

    Shortly before two o'clock on a chilly November afternoon in 1849, the celebrated Harvard physician and surgeon, Dr. George Parkman, left his home on Boston's fashionable Beacon Hill, expecting to return in a few hours. He was never seen alive again. This account describes Parkman's brutal murder and explores the dynamics which preceded this crime. It explains how and why Dr. John White Webster, MD, Professor of Chemistry and Mineralogy at Harvard University, killed Dr. Parkman and unsuccessfully attempted to destroy the physical evidence. Webster's subsequent trial, conviction and ultimate punishment are also detailed. The Parkman-Webster case remains one of the classic murders in the annals of American crime. Compelling dental evidence presented by the famous American dentist, Dr. Nathan Cooley Keep, directly led to the conviction of Dr. Webster. This graphic, ground-breaking case clearly established the viable role of forensic dentistry in legal criminal investigation.

  1. Carbon Stars from LAMOST DR2 Data

    NASA Astrophysics Data System (ADS)

    Ji, Wei; Cui, Wenyuan; Liu, Chao; Luo, Ali; Zhao, Gang; Zhang, Bo

    2016-09-01

    In this work, we present the new catalog of carbon stars from the LAMOST DR2 catalog. In total, 894 carbon stars are identified from multiple line indices measured from the stellar spectra. We are able to identify the carbon stars by combining the CN bands in the red end with C2 and other lines. Moreover, we also classify the carbon stars into spectral sub-types of C–H, C–R, and C–N. These sub-types show distinct features in the multi-dimensional line indices, implying that in the future they can be used to identify carbon stars from larger spectroscopic data sets. While the C–N stars are clearly separated from the others in the line index space, we find no clear separation between the C–R and C–H sub-types. The C–R and C–H stars seem to smoothly transition from one to another. This may hint that the C–R and C–H stars may not be different in their origins, instead their spectra look different because of different metallicities. Due to the relatively low spectral resolution and lower signal-to-noise ratio, the ratio of 12C/13C is not measured and thus the C–J stars are not identified.

  2. Dr. Otto "Tiger" Freer: inventor and innovator.

    PubMed

    Chittiboina, Prashant; Connor, David E; Nanda, Anil

    2012-08-01

    Every neurosurgeon develops his or her own standard approach to common intracranial pathologies in terms of the order in which different stages are performed and which instruments are used to perform individual tasks. The majority of the basic steps in performing a craniotomy are learned through repetition and practice during residency training. Significant amounts of energy are devoted to mastering technical skills and developing an operative rhythm. What often receives little attention is the historical origin of the instruments that make the work possible. The Freer elevator represents a particularly interesting example. To people unfamiliar with the accomplishments of turn-of-the-century laryngologist Otto "Tiger" Freer, it can be assumed that the name of the instrument in one's hand is simply named for what it can do, that is, to "free" the nasal mucosa from the bony and cartilaginous septum during the transsphenoidal approach. The technique this master surgeon spent his life and career perfecting is now repeated almost daily by skull base neurosurgeons approaching pathologies from the inferior frontal lobe to the foramen magnum. In reviewing his life and work, the authors of this paper discovered an interesting creative process that led to the design of the eponymous instrument. Additionally, they discovered important advances toward the development of the transnasal approach and in our understanding of the anterior skull base. They present a historical perspective on the life and accomplishments of Dr. Freer and the ubiquitous surgical instrument that he invented and popularized. PMID:22853830

  3. SDSS DR7 WHITE DWARF CATALOG

    SciTech Connect

    Kleinman, S. J.; Nitta, A.; Kepler, S. O.; Pelisoli, Ingrid; Pecanha, Viviane; Costa, J. E. S.; Koester, D.; Krzesinski, J.; Dufour, P.; Lachapelle, F.-R.; Bergeron, P.; Yip, Ching-Wa; Harris, Hugh C.; Eisenstein, Daniel J.; Althaus, L.; Corsico, A.

    2013-01-15

    We present a new catalog of spectroscopically confirmed white dwarf stars from the Sloan Digital Sky Survey (SDSS) Data Release 7 spectroscopic catalog. We find 20,407 white dwarf spectra, representing 19,712 stars, and provide atmospheric model fits to 14,120 DA and 1011 DB white dwarf spectra from 12,843 and 923 stars, respectively. These numbers represent more than a factor of two increase in the total number of white dwarf stars from the previous SDSS white dwarf catalogs based on DR4 data. Our distribution of subtypes varies from previous catalogs due to our more conservative, manual classifications of each star in our catalog, supplementing our automatic fits. In particular, we find a large number of magnetic white dwarf stars whose small Zeeman splittings mimic increased Stark broadening that would otherwise result in an overestimated log g if fit as a non-magnetic white dwarf. We calculate mean DA and DB masses for our clean, non-magnetic sample and find the DB mean mass is statistically larger than that for the DAs.

  4. Carbon Stars from LAMOST DR2 Data

    NASA Astrophysics Data System (ADS)

    Ji, Wei; Cui, Wenyuan; Liu, Chao; Luo, Ali; Zhao, Gang; Zhang, Bo

    2016-09-01

    In this work, we present the new catalog of carbon stars from the LAMOST DR2 catalog. In total, 894 carbon stars are identified from multiple line indices measured from the stellar spectra. We are able to identify the carbon stars by combining the CN bands in the red end with C2 and other lines. Moreover, we also classify the carbon stars into spectral sub-types of C-H, C-R, and C-N. These sub-types show distinct features in the multi-dimensional line indices, implying that in the future they can be used to identify carbon stars from larger spectroscopic data sets. While the C-N stars are clearly separated from the others in the line index space, we find no clear separation between the C-R and C-H sub-types. The C-R and C-H stars seem to smoothly transition from one to another. This may hint that the C-R and C-H stars may not be different in their origins, instead their spectra look different because of different metallicities. Due to the relatively low spectral resolution and lower signal-to-noise ratio, the ratio of 12C/13C is not measured and thus the C-J stars are not identified.

  5. Dr. Hall and the work cure.

    PubMed

    Reed, Kathlyn L

    2005-01-01

    Herbert James Hall, MD (1870-1923), was a pioneer in the systematic and organized study of occupation as therapy for persons with nervous and mental disorders that he called the "work cure." He began his work in 1904 during the early years of the Arts and Crafts Movement in the United States. His primary interest was the disorder neurasthenia, a condition with many symptoms including chronic fatigue, stress, and inability to work or perform everyday tasks. The prevailing treatment of the day was absolute bed rest known as the "rest cure." Hall believed that neurasthenia was not caused by overwork but by faulty living habits that could be corrected through an ordered life schedule and selected occupations. He identified several principles of therapy that are still used today including graded activity and energy conservation. Dr. Adolph Meyer credits Hall for organizing the ideas on the therapeutic use of occupation (Meyer, 1922). Hall also provided the name American Occupational Therapy Association for the professional organization and served as the fourth president. For his many contributions to the profession Hall deserves to be recognized as a major contributor to the development and organization of occupational therapy. PMID:23927746

  6. Dr. Otto "Tiger" Freer: inventor and innovator.

    PubMed

    Chittiboina, Prashant; Connor, David E; Nanda, Anil

    2012-08-01

    Every neurosurgeon develops his or her own standard approach to common intracranial pathologies in terms of the order in which different stages are performed and which instruments are used to perform individual tasks. The majority of the basic steps in performing a craniotomy are learned through repetition and practice during residency training. Significant amounts of energy are devoted to mastering technical skills and developing an operative rhythm. What often receives little attention is the historical origin of the instruments that make the work possible. The Freer elevator represents a particularly interesting example. To people unfamiliar with the accomplishments of turn-of-the-century laryngologist Otto "Tiger" Freer, it can be assumed that the name of the instrument in one's hand is simply named for what it can do, that is, to "free" the nasal mucosa from the bony and cartilaginous septum during the transsphenoidal approach. The technique this master surgeon spent his life and career perfecting is now repeated almost daily by skull base neurosurgeons approaching pathologies from the inferior frontal lobe to the foramen magnum. In reviewing his life and work, the authors of this paper discovered an interesting creative process that led to the design of the eponymous instrument. Additionally, they discovered important advances toward the development of the transnasal approach and in our understanding of the anterior skull base. They present a historical perspective on the life and accomplishments of Dr. Freer and the ubiquitous surgical instrument that he invented and popularized.

  7. Dr. Samuel Ting, nobel laureate, visits SSPF.

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Nobel laureate Professor Samuel C. C. Ting of the Massachusetts Institute of Technology pauses for a photo in the Space Station Processing Facility. Dr. Ting is directing an experiment, an international collaboration of some 37 universities and laboratories, using a state-of-the-art particle physics detector called the Alpha Magnetic Spectrometer (AMS), which will fly on a future launch to the International Space Station. Using the unique environment of space, the AMS will study the properties and origin of cosmic particles and nuclei including antimatter and dark matter. AMS flew initially as a Space Shuttle payload on the June 1998 mission STS-91 that provided the investigating team with data on background sources and verified the detector's performance under actual space flight conditions. The detector's second space flight is scheduled to be launched on mission UF-4 October 2003 for installation on the Space Station as an attached payload. Current plans call for operating the detector for three years before it is returned to Earth on the Shuttle. Using the Space Station offers the science team the opportunity to conduct the long-duration research above the Earth's atmosphere necessary to collect sufficient data required to accomplish the science objectives.

  8. 78 FR 29781 - Before Administrative Judges: Ronald M. Spritzer, Chairman, Dr. Anthony J. Baratta, Dr. Randall J...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-21

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Atomic Safety and Licensing Board Before Administrative Judges: Ronald M. Spritzer, Chairman, Dr. Anthony J. Baratta, Dr. Randall J. Charbeneau; In the Matter of Detroit Edison Company (Fermi...

  9. Oligonucleotide-genotyping as a method of detecting the HLA-DR2 (DRw15)-Dw2, -DR2 (DRw15)-Dw12, -DR4-Dw15, and -DR4-D"KT2" haplotypes in the Japanese population.

    PubMed

    Obata, F; Ito, I; Kaneko, T; Ohkubo, M; Ishimoto, A L; Abe, A; Kashiwagi, N

    1989-05-01

    We synthesized pairs of four different oligonucleotides, F22, F29, F42, and F158, to analyse the HLA-DR2 (DRw15) and -DR4 haplotypes in the Japanese population. After enzymatically amplifying the HLA-DRB1 gene, we hybridized the oligonucleotide probes with DNA extracted from 42 donors. Hybridization was completed between F22 and the DNA of haplotype DR2 (DRw15)-Dw2, between F29 and the DNA of DR2 (DRw15)-Dw12, between F42 and the DNA of DR4-D"KT2", and between F158 and the DNA of DR4-Dw15. In keeping with the nucleotide sequences of the probes, F29 hybridized also with DNA from the DR9-Dw23 haplotype and F158 with that from some of the DRw8 haplotypes (DRw8-Dw8.3) in the Japanese population. Results of this study demonstrate that the four oligonucleotides make useful probes for detecting the haplotypes above.

  10. The decisive decade. Interview: Dr. Nafis Sadik.

    PubMed

    1989-01-01

    The interview with Dr. Nafis Sadik, Director of the UN Family Planning Association (UNFPA), involved questions about the Fund's major achievements, the effect of withdrawal of US funds on UNFPA programs, the role of UNFPA in bridging environmental, population, and development objectives as stated in the Bruntland Commission initiatives, awareness building, the role of UNFPA in dealing with resource deficits in countries with high growth populations, the seriousness of the 1990s decade as critical to the future. and UNFPA's priorities for the next 10 years. The Fund's accomplishments are in getting political systems to recognize as an important part of development, in broadening the concept of population to include quality of life and spatial distribution and growth, and in obtaining funding to continue operating without US funds. The US withdrawal of funds has affected UNFPA's funding in Africa since 1985. UNFPA is actively working to help other agencies integrate FP into conservation strategies, and to consider the education of women and provision for FP information in a variety of programs. Sustainable development must occur at the grass roots level, or from the ground up. Programs must be implemented with an understanding of local needs and desires and with cultural sensitivity. A review of findings over 20 years led to an understanding that many countries had no strategy or plans for population programs even with a lot of development assistance, and programs were transplanted without consideration of local needs. UNFPA is not urging that national development strategies must incorporate population planning, and to target education to young people who will soon be entering reproductive ages during the decade ahead. Governments have begun to recognize that the next 10 years will determine the future, and population does affect the crisis of resources. UNFPA's priorities are to the education of youth, to design special curricula in schools for educating about

  11. [Dr. Halfdan Mahler's speech in Guatemala].

    PubMed

    Mahler, H

    1989-12-01

    A major focus of Dr. Mahler throughout his life has been the war against female discrimination and to reduce the extreme inequalities between men and women. The Latin American Region of IPPF selected the participation of women as its goal for the decade of the 90's. It is known that fertility is inversely related to female education and occupation, and that the poorest homes worldwide are those headed by poor and illiterate women. The number of female-headed households is increasing and in Barbados, Dominica, Honduras, Jamaica, Nicaragua, Panama and Uruguay these have increased by 31% Married women often find that their husbands are the main obstacles to family planning services. Violence against women takes many forms including physical abuse, adolescent pregnancy, psychological and economic stress, the "machismo" syndrome, and having unwanted pregnancies. Latin America and the Caribbean pregnancy and illegal abortion account for the high mortality rates among those 15-19. Men must face the consequences of the socioeconomic conditions that they have created for women. For example if FPP were designed to really reflect a women's perspective such programs would have reached the goals of success. He recommends that IPPF's goal for the Year 2000 will be to have 9 women to each man in Committees of 10. He suggests that changes towards women must begin with the men themselves so that policies and programs reflect these new attitudes. If society wants a less aggressive and materialistic world, then the role of women must be raised so that her contribution can be felt worldwide.

  12. Evidence for a new HLA class II determinant present on cells from HLA-DR1 and/or -DR4 individuals.

    PubMed

    Lepage, V; Alcalay, D; Douay, C; Mallet, C; Loiseau, P; Degos, L; Colombani, M; Colombani, J

    1985-02-01

    Evidence for a new HLA class II specificity is presented. It is recognized by LE serum, which reacts with most DR1 and/or DR4 individuals (r = 0.86). Its frequency in the French population is 0.33. Absorption-elution experiments showed that the serum reactivity was not due to a mixture of anti-DR1 and anti-DR4 antibodies, but to a single antibody population which could be absorbed on and eluted from both DR1(+) or DR4(+) cells. LE specificity seemed to be expressed on DR but not on DQ molecules since the serum reacted with and could be absorbed by DR+,DQw- cells; it did not react with a DR-,DQw+ mutant cell, but did react with the DR+,DQw+ parental cell. The relationship between LE specificity and MC1 and Te23 specificities remains to be determined. PMID:2581334

  13. Pathogenesis of Afa/Dr Diffusely Adhering Escherichia coli

    PubMed Central

    Servin, Alain L.

    2005-01-01

    Over the last few years, dramatic increases in our knowledge about diffusely adhering Escherichia coli (DAEC) pathogenesis have taken place. The typical class of DAEC includes E. coli strains harboring AfaE-I, AfaE-II, AfaE-III, AfaE-V, Dr, Dr-II, F1845, and NFA-I adhesins (Afa/Dr DAEC); these strains (i) have an identical genetic organization and (ii) allow binding to human decay-accelerating factor (DAF) (Afa/DrDAF subclass) or carcinoembryonic antigen (CEA) (Afa/DrCEA subclass). The atypical class of DAEC includes two subclasses of strains; the atypical subclass 1 includes E. coli strains that express AfaE-VII, AfaE-VIII, AAF-I, AAF-II, and AAF-III adhesins, which (i) have an identical genetic organization and (ii) do not bind to human DAF, and the atypical subclass 2 includes E. coli strains that harbor Afa/Dr adhesins or others adhesins promoting diffuse adhesion, together with pathogenicity islands such as the LEE pathogenicity island (DA-EPEC). In this review, the focus is on Afa/Dr DAEC strains that have been found to be associated with urinary tract infections and with enteric infection. The review aims to provide a broad overview and update of the virulence aspects of these intriguing pathogens. Epidemiological studies, diagnostic techniques, characteristic molecular features of Afa/Dr operons, and the respective role of Afa/Dr adhesins and invasins in pathogenesis are described. Following the recognition of membrane-bound receptors, including type IV collagen, DAF, CEACAM1, CEA, and CEACAM6, by Afa/Dr adhesins, activation of signal transduction pathways leads to structural and functional injuries at brush border and junctional domains and to proinflammatory responses in polarized intestinal cells. In addition, uropathogenic Afa/Dr DAEC strains, following recognition of β1 integrin as a receptor, enter epithelial cells by a zipper-like, raft- and microtubule-dependent mechanism. Finally, the presence of other, unknown virulence factors and the way that

  14. 74. ARAII. Dr. William Zinn of combustion engineering company and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    74. ARA-II. Dr. William Zinn of combustion engineering company and others at controls of SL-1. August 8, 1959. Ineel photo no. 59-4109. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

  15. GOES-R with Dr. Kathy Sullivan and Tim Samaras

    NASA Video Gallery

    This short video features highlights from a live Nationwide broadcast that took place on April 3, 2012, from the studio of NASA Goddard TV. NOAA’s Deputy Administrator and Chief Scientist Dr. Ka...

  16. Grantee Spotlight: Dr. Kolawole Okuyemi - Improving Cervical Cancer Screening Attitudes

    Cancer.gov

    Dr. Kolawole Okuyumi is studying cervical cancer screening attitudes and behaviors of African immigrants and refugees in Minnesota, and introducing “cancer” and “cervix” to their everyday vocabulary.

  17. Dr. von Braun Escorts President Kennedy and Vice President Johnson

    NASA Technical Reports Server (NTRS)

    1962-01-01

    Marshall Space Flight Center Director Dr. Wernher von Braun explains a detail from a Saturn IB mockup and engine to President John F. Kennedy, Vice President Lyndon Johnson and other guests, September 11, 1962.

  18. NES Live Video Chat: Dr. John C. Mather

    NASA Video Gallery

    NES welcomed Nobel Prize winner Dr. John C. Mather for a video webchat on May 17, 2011. He spoke about the James Webb Space Telescope and how it gives us a look into the past to see how galaxies ha...

  19. Dr. Wernher Von Braun at the launch of Apollo 11.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Mission officials relax, all smiles, a few moments after the successful launch of the Apollo 11 spacecraft by Saturn V vehicle AS-506. Relieved of the tension of waiting through the countdown are (left to right) Charles W. Matthews, NASA deputy associate administrator for manned space flight; Dr. Wernher Von Braun, Director of the Marshall Space Flight Center; Dr. George E. Meuller, NASA associate administrator for manned spaceflight, and Lt. General Samuel C. Phillips, director of the Apollo program.

  20. Portrait of Dr. Von Braun with Walt Disney, 1954.

    NASA Technical Reports Server (NTRS)

    1954-01-01

    Marshall Center Director Dr. Wernher Von Braun is pictured with Walt Disney during a visit to the Marshall Space Flight Center in 1954. In the 1950s, Dr. Von Braun while working in California on the Saturn project, also worked with Disney studios as a technical director in making three films about Space Exploration for television. Disney's tour of Marshall in 1965 was Von Braun's hope for a renewed public interest in the future of the Space Program at NASA.

  1. Dr. Peter Emil Becker and the Third Reich.

    PubMed

    Hill, Frank

    2013-08-01

    In 1985 the physician after whom Becker Muscular Dystrophy is named, German neurologist Dr. Peter Emil Becker (1908-2000), published an autobiographical article in the American Journal of Medical Genetics in which he disavowed any association with the Nazi Party. A closer look at the evidence, however, suggests otherwise. Review of war records and related sources raise concern for Dr. Becker's affiliation with the Nazi Party and his contributions to its ideology.

  2. Dr. von Braun at 'Wernher von Braun Day' Celebration

    NASA Technical Reports Server (NTRS)

    1970-01-01

    In 1970 Marshall Space Flight Center (MSFC) Director Dr. Wernher von Braun (right) was reassigned to NASA Headquarters to serve as Deputy Associate Administrator for Plarning. Prior to his transfer, Dr. von Braun was honored for his career in Huntsville, Alabama, with the celebration of 'Wernher von Braun Day.' Among those participating were Alabama Governor Albert Brewer (left) and Alabama Senator John Sparkman (center). (Courtesy of Huntsville/Madison County Public library)

  3. Dr-FtsA, an actin homologue in Deinococcus radiodurans differentially affects Dr-FtsZ and Ec-FtsZ functions in vitro.

    PubMed

    Modi, Kruti; Misra, Hari S

    2014-01-01

    The Deinococcus radiodurans genome encodes homologues of divisome proteins including FtsZ and FtsA. FtsZ of this bacterium (Dr-FtsZ) has been recently characterized. In this paper, we study FtsA of D. radiodurans (Dr-FtsA) and its involvement in regulation of FtsZ function. Recombinant Dr-FtsA showed neither ATPase nor GTPase activity and its polymerization was ATP dependent. Interestingly, we observed that Dr-FtsA, when compared with E. coli FtsA (Ec-FtsA), has lower affinity for both Dr-FtsZ and Ec-FtsZ. Also, Dr-FtsA showed differential effects on GTPase activity and sedimentation characteristics of Dr-FtsZ and Ec-FtsZ. For instance, Dr-FtsA stimulated GTPase activity of Dr-FtsZ while GTPase activity of Ec-FtsZ was reduced in the presence of Dr-FtsA. Stimulation of GTPase activity of Dr-FtsZ by Dr-FtsA resulted in depolymerization of Dr-FtsZ. Dr-FtsA effects on GTPase activity and polymerization/depolymerisation characteristics of Dr-FtsZ did not change significantly in the presence of ATP. Recombinant E. coli expressing Dr-FtsA showed cell division inhibition in spite of in trans expression of Dr-FtsZ in these cells. These results suggested that Dr-FtsA, although it lacks ATPase activity, is still functional and differentially affects Dr-FtsZ and Ec-FtsZ function in vitro.

  4. Biochemical characteristic of biofilm of uropathogenic Escherichia coli Dr(+) strains.

    PubMed

    Zalewska-Piątek, Beata; Wilkanowicz, Sabina; Bruździak, Piotr; Piątek, Rafał; Kur, Józef

    2013-07-19

    Urinary tract infections caused by Escherichia coli are very common health problem in the developed countries. The virulence of the uropathogenic E. coli Dr(+) IH11128 is determined by Dr fimbriae, which are homopolymeric structures composed of DraE subunits with the DraD protein capping the fiber. In this study, we have analyzed the structural and biochemical properties of biofilms developed by E. coli strains expressing Dr fimbriae with or without the DraD tip subunit and the surface-exposed DraD protein. We have also demonstrated that these E. coli strains form biofilms on an abiotic surface in a nutrient-dependent fashion. We present evidence that Dr fimbriae are necessary during the first stage of bacterial interaction with the abiotic surface. In addition, we reveal that the DraD alone is also sufficient for the initial surface attachment at an even higher level than Dr fimbriae and that chloramphenicol is able to reduce the normal attachment of the analyzed E. coli. The action of chloramphenicol also shows that protein synthesis is required for the early events of biofilm formation. Additionally, we have identified reduced exopolysaccharide coverage in E. coli that express only Dr fimbrial polyadhesins at the cell surface with or without the DraD capping subunit.

  5. Study of photoluminescence properties of thin films DR1

    SciTech Connect

    Herman, Ulya, Naily

    2015-09-30

    Fabrication of thin films DR1 have been carried out by the EFA-PDF (Electric Field-Assisted Physical Vapor Deposition) method to obtain films with parallel dipole arrangement. Molecular deposition process is performed by applying an electric field that is placed between the substrate ITO (Indium Tin Oxide) and copper mesh. The resulting films were characterized by using a spectrofluorometer. Analysis of the emission spectrum, indicate that DR1 molecules in the film oriented perpendicular to the substrate and arranged in parallel order (H-aggregate). As an effect, the peak of the emission spectrum appears stronger along with the increase of electric field strength.

  6. Sequence and evolution of HLA-DR7- and -DRw53-associated beta-chain genes.

    PubMed

    Young, J A; Wilkinson, D; Bodmer, W F; Trowsdale, J

    1987-07-01

    cDNA clones representing products of the DR7 and DRw53 beta-chain genes were isolated from the human B-lymphoblastoid cell line MANN (DR7,DRw53,DQw2, DPw2). The DRw53 beta sequence was identical to a DRw53 beta sequence derived from cells with a DR4 haplotype. In contrast, the DR7 beta sequence was as unrelated to DR4 beta sequence as it was to other DR beta-related genes, except at the 3'-untranslated region. These results suggest that the DR7 and DR4 haplotypes may have been derived relatively recently from a common ancestral haplotype and that the DR4 and DR7 beta-chain genes have undergone more rapid diversification in their beta 1 domains, most probably as a result of natural selection, than have the DRw53 beta-chain genes. Short tracts of sequence within the DR7 and DRw53 beta 1 domains were shared with other DR beta sequences, indicating that exchanges of genetic information between beta 1 domains of DR beta-related genes have played a part in their evolution. Serological analysis of mouse L-cell transfectants expressing surface HLA-DR7 molecules, confirmed by antibody binding and allelic sequence comparisons, identified amino acid residues that may be critical to the binding of a monomorphic DR- and DP-specific monoclonal antibody.

  7. STATISTICAL STUDY OF 2XMMi-DR3/SDSS-DR8 CROSS-CORRELATION SAMPLE

    SciTech Connect

    Zhang Yanxia; Zhou Xinlin; Zhao Yongheng; Wu Xuebing

    2013-02-01

    Cross-correlating the XMM-Newton 2XMMi-DR3 catalog with the Sloan Digital Sky Survey (SDSS) Data Release 8, we obtain one of the largest X-ray/optical catalogs and explore the distribution of various classes of X-ray emitters in the multidimensional photometric parameter space. Quasars and galaxies occupy different zones while stars scatter in them. However, X-ray active stars have a certain distributing rule according to spectral types. The earlier the type of stars, the stronger its X-ray emitting. X-ray active stars have a similar distribution to most stars in the g - r versus r - i diagram. Based on the identified samples with SDSS spectral classification, a random forest algorithm for automatic classification is performed. The result shows that the classification accuracy of quasars and galaxies adds up to more than 93.0% while that of X-ray emitting stars only amounts to 45.3%. In other words, it is easy to separate quasars and galaxies, but it is difficult to discriminate X-ray active stars from quasars and galaxies. If we want to improve the accuracy of automatic classification, it is necessary to increase the number of X-ray emitting stars, since the majority of X-ray emitting sources are quasars and galaxies. The results obtained here will be used for the optical spectral survey performed by the Large sky Area Multi-Object fiber Spectroscopic Telescope (LAMOST, also named the Guo Shou Jing Telescope), which is a Chinese national scientific research facility operated by the National Astronomical Observatories, Chinese Academy of Sciences.

  8. Dr. David Sawyer, Mickey Mouse and Dr. David Brown attend a ceremony at Ronald McNair Middle School

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. David Sawyer (left), Superintendent of the Brevard County School District, Mickey Mouse, and Dr. David Brown, a NASA astronaut, attend a tribute to NASA astronaut Ronald McNair held in the gymnasium of Ronald McNair Magnet School in Cocoa, Fla. During the tribute, Walt Disney World presented a portrait of McNair to the school, which had previously been renamed for the fallen astronaut. McNair was one of a crew of seven who lost their lives during an accident following launch of the Space Shuttle Challenger in January 1986.

  9. Dr. Seuss's Sound Words: Playing with Phonics and Spelling.

    ERIC Educational Resources Information Center

    Gardner, Traci

    Boom! Br-r-ring! Cluck! Moo!--exciting sounds are everywhere. Whether visiting online sites that play sounds or taking a "sound hike," ask your students to notice the sounds they hear, then write their own book, using sound words, based on Dr. Seuss's "Mr. Brown Can MOO! Can You?" During the three 45-minute sessions, grade K-2 students will:…

  10. Another Use for Dr. Seuss: Reading for Social Skills

    ERIC Educational Resources Information Center

    Wolf, Janice J.; Baker, Pamela Hudson

    2012-01-01

    Time is limited. Teachers often struggle to address the diverse needs of learners in their classrooms, especially when faced with academic and social skills concerns. Finding effective ways to teach social skills in the context of academic instruction makes sense. Books by Dr. Seuss provide a variety of high-interest stories that can be used to…

  11. Dr. Wernher Von Braun with Congressman Gerald R. fod

    NASA Technical Reports Server (NTRS)

    1999-01-01

    On a visit to the Marshall Space Flight Center in April, 1964, Congressman Gerald R. Ford, Jr. Republican of Michigan, was warmly greeted by Dr. Wernher Von Braun, Marshall Space Flight Center director. Ford, along with two other congressmen, visited the center for a briefing on the Saturn program and for a tour of the facilities.

  12. 3. View of middle DR 2 antenna looking north 30 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. View of middle DR 2 antenna looking north 30 degrees west and showing radar scanner building no. 105 east face through antenna. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  13. 2. View of southerly DR 1 antenna looking north 25 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. View of southerly DR 1 antenna looking north 25 degrees west and and showing radar scanner building no. 105 east face through antenna. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  14. 7. View of DR 3 antenna typical front stay concrete ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. View of DR 3 antenna typical front stay concrete showing embedment anchors, foundation steel base plate, vertical member with small diameter turnbuckles, antenna assembly in background, and story board for scale. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  15. Dr. Edward de Bono's Six Thinking Hats and Numeracy

    ERIC Educational Resources Information Center

    Paterson, Anne

    2006-01-01

    In education, the term "metacognition" describes thinking about thinking. Within mathematics, the term "metacomputation" describes thinking about computational methods and tools. This article shows how Dr. Edward de Bono's Six Thinking Hats can be used to demonstrate metacognition and metacomputation in the primary classroom. The article suggests…

  16. Dr. Chad E. Finn, 2013 Wilder Medal Recipient

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Dr. Chad Finn took over the leadership of the USDA-ARS small fruit breeding program in Corvallis, Oregon in 1993 after three years working as an extension horticulturist in the Department of Horticulture at the University of Missouri, Columbia. Since taking over this program he has developed what is...

  17. A Dr. Martin Luther King, Jr. Curriculum: Playing the Dream.

    ERIC Educational Resources Information Center

    Clemens, Sydney Gurewitz

    1988-01-01

    Discusses curriculum for young children centered around the beliefs and teachings of Dr. Martin Luther King, Jr. His works are interpreted in a human rights context in which children find their voice in the peaceable resolution of everyday conflicts. Describes the Child of the Day program. (Author/RWB)

  18. Dr. Martin Luther King, Jr. Washington State Resource Guide.

    ERIC Educational Resources Information Center

    Washington Office of the State Superintendent of Public Instruction, Olympia, WA. Div. of Instructional Programs and Services.

    The Washington State Resource Guide on Martin Luther King, Jr., supplies a wide variety of materials for use with all grade levels in classroom and assembly presentations in public schools. The goal is for every child enrolled in Washington State schools to learn about Dr. King during the days of January 15 to January 17. Resolutions supporting an…

  19. Gifted Kids, Social Issues, and the Works of Dr. Seuss

    ERIC Educational Resources Information Center

    Granada, Jim

    2005-01-01

    Gifted students often share a sense of justice and a concern for the welfare of mankind and the planet. This humanitarian feeling may sometimes be overlooked, given today's academic focus. The author has taken an in-depth look at the works of Theodor Geisel, popularly known as Dr. Seuss, and moved beyond his whimsical illustrations and wordplay to…

  20. 39. View of checkout indicator computer console for DR beams, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    39. View of checkout indicator computer console for DR beams, TR chains, and special checkout target control located in CSMR in transmitter building no. 102. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  1. Trial by Newspaper: The Strange Case of Dr. Karl Muck.

    ERIC Educational Resources Information Center

    Kagan, Sheldon S.

    1993-01-01

    Examines the case of Dr. Karl Muck, conductor of the Boston Symphony Orchestra who was accused of espionage in 1917. Suggests that the espionage charge was a fiction created by newspapers, beginning with "The Providence Journal." Concludes that Muck admitted to being a spy rather than reveal the name of the woman with whom he had an extramarital…

  2. Dr. von Braun With a Model of a Launch Vehicle

    NASA Technical Reports Server (NTRS)

    1950-01-01

    Dr. von Braun stands beside a model of the upper stage (Earth-returnable stage) of the three-stage launch vehicle built for the series of the motion picture productions of space flight produced by Walt Disney in the mid-1950's.

  3. Oxygen and Metastasis: A Conversation with Dr. Nick Restifo

    Cancer.gov

    Dr. Nick Restifo, a senior investigator in NCI’s Center for Cancer Research, discusses his recently published study finding that Oxygen, a molecule necessary for life, paradoxically aids cancer metastasis to the lung by impairing cancer-killing immune cells.

  4. Bullying Among Teenage Girls: An Interview with Dr. Harriet Mosatche

    ERIC Educational Resources Information Center

    Prevention Researcher, 2004

    2004-01-01

    Dr. Harriet Mosatche is an advice columnist on a web site for teen girls, as well as the Senior Director of Research and Programs at the Girl Scouts of the USA. Because of these dual roles, she has a unique perspective on the bullying issue. In this interview she answers a number of questions about bullying among teenage girls, including how boys…

  5. 6. View of DR 3 antenna typical backstay concrete stanchion ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. View of DR 3 antenna typical back-stay concrete stanchion showing embedded anchors and structural steel leg with pin attachment. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  6. 28. View of data test area for DR data take ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    28. View of data test area for DR data take off set operators panel and cabinet at second floor of transmitter building no. 102 in MIP area. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  7. Effect of Selenium on HLA-DR Expression of Thyrocytes

    PubMed Central

    Balázs, Csaba; Kaczur, Viktória

    2012-01-01

    Autoimmune thyroid diseases (ATDs) represent the most frequent forms of the organ-specific autoimmune thyroid disorders that result from interaction between genetic and environmental factors. Selenium has been shown to exert a beneficial effect on the autoimmune thyroiditis. In spite of therapeutical effect of selenium on autoimmunity, the mechanism of its action has not been revealed. Objective. To determine whether selenium in vitro thyrocytes cultures are able to influence the HLA-DR molecule expression of human thyrocytes and production of free oxygen radicals. Method. Thyrocytes were prepared from human thyroid gland and cultured in vitro in the presence of interferon-γ and sodium selenite. The expression of HLA-DR molecules induced by interferon-γ in the presence of sodium selenite of various concentration was measured by fluorescence-activated cell sorter. Results. Selenium has a dose-dependent inhibitory effect on the expression of HLA-DR molecules of thyrocytes induced by interferon-γ. This effect of selenium was in the inverse correlation with antioxidative capacity. Conclusion. Beneficial effect of selenium on autoimmune mechanism is a complex mechanism in which the inhibitory effect on HLA-DR molecule expression and antioxidative capacity are involved into therapy of autoimmune thyroiditis. PMID:22400102

  8. Dr Skateboard's Action Science: Teaching Physics in Context

    ERIC Educational Resources Information Center

    Robertson, William H.

    2009-01-01

    In order to create student interest and promote new connections to the understanding of fundamental physics concepts, there is a need for new approaches and methods that are both contemporary and relevant. Dr Skateboard's Action Science, a curriculum supplement comprising video instruction and classroom activities, is an example that focuses on…

  9. CGS3DR: UKIRT CGS3 data reduction software

    NASA Astrophysics Data System (ADS)

    Bridger, Alan; Beard, Steven M.; Lightfoot, John F.; Krisciunas, Kevin; Daly, Phil N.

    2014-11-01

    CGS3DR is data reduction software for the UKIRT CGS3 mid-infrared grating spectrometer instrument. It includes a command-line interface and a GUI. The software, originally on VMS, was ported to Unix. It uses Starlink (ascl:1110.012) infrastructure libraries.

  10. 18. View from DR 2 antenna looking south 45 degrees ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. View from DR 2 antenna looking south 45 degrees west to backside transmitter building 101 and in left foreground showing site well system building. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  11. The life and legacy of Dr. Lee Baldwin

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This paper outlines the life and legacy of the late Dr. Ransom L. Baldwin, V. The purpose was to highlight the impact his teaching and research had on the international energy and protein metabolism communities at their fourth international conference. The paper will be presented at the outset of ...

  12. Dynamic Star Formation in the Massive DR21 Filament

    SciTech Connect

    Schneider, N.; Csengeri, T.; Bontemps, S.; Motte, F.; Simon, R.; Hennebelle, P.; Federrath, C.; Klessen, R.; /ZAH, Heidelberg /KIPAC, Menlo Park

    2010-08-25

    The formation of massive stars is a highly complex process in which it is unclear whether the star-forming gas is in global gravitational collapse or an equilibrium state supported by turbulence and/or magnetic fields. By studying one of the most massive and dense star-forming regions in the Galaxy at a distance of less than 3 kpc, i.e. the filament containing the well-known sources DR21 and DR21(OH), we attempt to obtain observational evidence to help us to discriminate between these two views. We use molecular line data from our {sup 13}CO 1 {yields} 0, CS 2 {yields} 1, and N{sub 2}H{sup +} 1 {yields} 0 survey of the Cygnus X region obtained with the FCRAO and CO, CS, HCO{sup +}, N{sub 2}H{sup +}, and H{sub 2}CO data obtained with the IRAM 30m telescope. We observe a complex velocity field and velocity dispersion in the DR21 filament in which regions of the highest column-density, i.e., dense cores, have a lower velocity dispersion than the surrounding gas and velocity gradients that are not (only) due to rotation. Infall signatures in optically thick line profiles of HCO{sup +} and {sup 12}CO are observed along and across the whole DR21 filament. By modelling the observed spectra, we obtain a typical infall speed of {approx}0.6 km s{sup -1} and mass accretion rates of the order of a few 10{sup -3} M{sub {circle_dot}} yr{sup -1} for the two main clumps constituting the filament. These massive clumps (4900 and 3300 M{sub {circle_dot}} at densities of around 10{sup 5} cm{sup -3} within 1 pc diameter) are both gravitationally contracting. The more massive of the clumps, DR21(OH), is connected to a sub-filament, apparently 'falling' onto the clump. This filament runs parallel to the magnetic field. Conclusions. All observed kinematic features in the DR21 filament (velocity field, velocity dispersion, and infall), its filamentary morphology, and the existence of (a) sub-filament(s) can be explained if the DR21 filament was formed by the convergence of flows on large

  13. Functional polymorphism of each of the two HLA-DR beta chain loci demonstrated with antigen-specific DR3- and DRw52-restricted T cell clones

    PubMed Central

    1988-01-01

    HLA-DR3- and HLA-DRw52-associated functional polymorphism was investigated with selected tetanus toxoid (TT)-specific T cell clones. We have shown earlier that HLA-DR antigens are encoded by two distinct loci, DR beta I and DR beta III. The alloantigenic determinant(s) defined by the serological HLA-DR3 specificity map to the former, while the supratypic HLA-DRw52 determinants map to DR beta III. Furthermore, we have recently recognized by DNA sequencing three alleles of HLA- DRw52 at locus DR beta III, referred to as 52 a, b, and c. Our objective was to correlate the pattern of T cell restriction with the gene products of individual DR beta chain loci and with the three newly described alleles of locus DR beta III. Among the selected T cell clones, 5 reacted exclusively when TT was presented by HLA-DR3+ APCs (TT-DR3-APC). In contrast, two T cell clones were stimulated by TT- DRw52-APC. More specifically, these two T cell clones (Clones 10 and 16) were stimulated by different subsets of TT-DRw52-APC. Clone 16 responded to some DR3 and TT-DRw6-APC, while clone 10 was stimulated by other TT-DR3 and TT-DRw6, and all TT-DR5-APC. This same pattern of DRw52 restriction was found in panel, as well as in family studies. Because this suggested a correlation with the pattern of DRw52 polymorphism observed earlier by DNA sequencing and oligonucleotide hybridization, the APC used in these experiments were typed for the 52 a, b, and c alleles of locus DR beta III by allele-specific oligonucleotide probes. This distribution overlapped exactly with the stimulation pattern defined by the T cell clones. Clone 16 responded to TT-52a-APC, clone 10 to TT-52b-APC, and both clones to a TT-52c-APC. The response of the T cell clones was inhibited differentially by mAbs to DR. Raising TT concentration, or increasing HLA-class II expression with INF-gamma both affected the magnitude of response of the TT- specific clones but did not modify their specificities. These results demonstrate that

  14. Sampling From the Proteome to the Human Leukocyte Antigen-DR (HLA-DR) Ligandome Proceeds Via High Specificity.

    PubMed

    Mommen, Geert P M; Marino, Fabio; Meiring, Hugo D; Poelen, Martien C M; van Gaans-van den Brink, Jacqueline A M; Mohammed, Shabaz; Heck, Albert J R; van Els, Cécile A C M

    2016-04-01

    Comprehensive analysis of the complex nature of the Human Leukocyte Antigen (HLA) class II ligandome is of utmost importance to understand the basis for CD4(+)T cell mediated immunity and tolerance. Here, we implemented important improvements in the analysis of the repertoire of HLA-DR-presented peptides, using hybrid mass spectrometry-based peptide fragmentation techniques on a ligandome sample isolated from matured human monocyte-derived dendritic cells (DC). The reported data set constitutes nearly 14 thousand unique high-confident peptides,i.e.the largest single inventory of human DC derived HLA-DR ligands to date. From a technical viewpoint the most prominent finding is that no single peptide fragmentation technique could elucidate the majority of HLA-DR ligands, because of the wide range of physical chemical properties displayed by the HLA-DR ligandome. Our in-depth profiling allowed us to reveal a strikingly poor correlation between the source proteins identified in the HLA class II ligandome and the DC cellular proteome. Important selective sieving from the sampled proteome to the ligandome was evidenced by specificity in the sequences of the core regions both at their N- and C- termini, hence not only reflecting binding motifs but also dominant protease activity associated to the endolysosomal compartments. Moreover, we demonstrate that the HLA-DR ligandome reflects a surface representation of cell-compartments specific for biological events linked to the maturation of monocytes into antigen presenting cells. Our results present new perspectives into the complex nature of the HLA class II system and will aid future immunological studies in characterizing the full breadth of potential CD4(+)T cell epitopes relevant in health and disease.

  15. Sampling From the Proteome to the Human Leukocyte Antigen-DR (HLA-DR) Ligandome Proceeds Via High Specificity*

    PubMed Central

    Mommen, Geert P. M.; Marino, Fabio; Meiring, Hugo D.; Poelen, Martien C. M.; van Gaans-van den Brink, Jacqueline A. M.; Mohammed, Shabaz; Heck, Albert J. R.; van Els, Cécile A. C. M.

    2016-01-01

    Comprehensive analysis of the complex nature of the Human Leukocyte Antigen (HLA) class II ligandome is of utmost importance to understand the basis for CD4+ T cell mediated immunity and tolerance. Here, we implemented important improvements in the analysis of the repertoire of HLA-DR-presented peptides, using hybrid mass spectrometry-based peptide fragmentation techniques on a ligandome sample isolated from matured human monocyte-derived dendritic cells (DC). The reported data set constitutes nearly 14 thousand unique high-confident peptides, i.e. the largest single inventory of human DC derived HLA-DR ligands to date. From a technical viewpoint the most prominent finding is that no single peptide fragmentation technique could elucidate the majority of HLA-DR ligands, because of the wide range of physical chemical properties displayed by the HLA-DR ligandome. Our in-depth profiling allowed us to reveal a strikingly poor correlation between the source proteins identified in the HLA class II ligandome and the DC cellular proteome. Important selective sieving from the sampled proteome to the ligandome was evidenced by specificity in the sequences of the core regions both at their N- and C- termini, hence not only reflecting binding motifs but also dominant protease activity associated to the endolysosomal compartments. Moreover, we demonstrate that the HLA-DR ligandome reflects a surface representation of cell-compartments specific for biological events linked to the maturation of monocytes into antigen presenting cells. Our results present new perspectives into the complex nature of the HLA class II system and will aid future immunological studies in characterizing the full breadth of potential CD4+ T cell epitopes relevant in health and disease. PMID:26764012

  16. Human T cells expressing V beta 8 do not predominantly recognize DR2 alloantigen.

    PubMed

    Christmas, S E; Brew, R; Crosby, I; Gecim, I E; Sells, R A

    1992-06-01

    A panel of seven monoclonal antibodies recognizing human T-cell antigen receptor (TcR) V alpha or V beta subsets has been used to measure TcR gene expression in peripheral blood lymphocytes and mixed lymphocyte culture responses (MLR) between DR2- and DR2+ (DRw15+) donors. There were no significant differences between DR2- and DR2+ donors in per cent T cells in fresh peripheral blood labelled with any of these antibodies, which included an antibody recognizing V beta 8. This indicates strongly that increased negative selection of V beta 8+ T cells does not occur in DR2+ compared with DR2- individuals. In MLR between DR2- and DR2+ donors the only significant change compared with fresh peripheral lymphocytes was that T cells expressing V beta 5.1 were decreased in DR2- lymphocyte populations responding to DR2 alloantigen. No changes in levels of V beta 8+ T cells were detected in MLR between DR2- and DR2+ donors. This suggests that V beta 8+ T cells are not predominantly reactive against DR2 (DRw15). The data support the concept that alloreactivity against a single class II major histocompatibility complex (MHC) mismatch is mediated by T cells expressing a range of different TcR V beta molecules.

  17. Dr. Howard Jones, Jr. (1910-2015): In Memoriam

    PubMed Central

    Oehninger, S.; Kruger, T.F.

    2015-01-01

    We honor the life of Howard W. Jones, Jr., MD, 104, a pioneer and visionary in reproductive medicine, a dedicated mentor, internationally renowned gynecological surgeon, and the father of in vitro fertilization IVF) in the United States. Dr. Jones founded the Jones Institute for Reproductive Medicine, in Norfolk, Virginia, at Eastern Virginia Medical School, in 1983. Today, IVF has grown exponentially not only in its direct application but also in the development of newer techniques would have been unimaginable a couple of decades ago. Throughout the years Dr. Howard has been a teacher and a mentor to many around the world. To us he also was a friend, a supporter at the time of difficult decisions, someone who would inspire hope, ignite the imagination, and instill a love of learning and untangling some of the complexities of the field, even of the human condition. His leadership, vision, knowledge, enthusiasm and inquisitive mind will be missed.

  18. Dr. Harry Whelan With the Light Emitting Diode Probe

    NASA Technical Reports Server (NTRS)

    1999-01-01

    The red light from the Light Emitting Diode (LED) probe shines through the fingers of Dr. Harry Whelan, a pediatric neurologist at the Children's Hospital of Wisconsin in Milwaukee. Dr. Whelan uses the long waves of light from the LED surgical probe to activate special drugs that kill brain tumors. Laser light previously has been used for this type of surgery, but the LED light illuminates through all nearby tissues, reaching parts of tumors that shorter wavelengths of laser light carnot. The new probe is safer because the longer wavelengths of light are cooler than the shorter wavelengths of laser light, making the LED less likely to injure normal brain tissue near the tumor. Also, it can be used for hours at a time while still remaining cool to the touch. The probe was developed for photodynamic cancer therapy under a NASA Small Business Innovative Research Program grant. The program is part of NASA's Technology Transfer Department at the Marshall Space Flight Center.

  19. Star Formation in the DR21 Region (B)

    NASA Technical Reports Server (NTRS)

    2004-01-01

    [figure removed for brevity, see original site] Annotated mosaic

    Hidden behind a shroud of dust in the constellation Cygnus is an exceptionally bright source of radio emission called DR21. Visible light images reveal no trace of what is happening in this region because of heavy dust obscuration. In fact, visible light is attenuated in DR21 by a factor of more than 10,000,000,000,000,000,000,000,000,000,000,000,000,000 (ten thousand trillion heptillion).

    New images from NASA's Spitzer Space Telescope allow us to peek behind the cosmic veil and pinpoint one of the most massive natal stars yet seen in our Milky Way galaxy. The never-before-seen star is 100,000 times as bright as the Sun. Also revealed for the first time is a powerful outflow of hot gas emanating from this star and bursting through a giant molecular cloud.

    The upper image is a large-scale mosaic assembled from individual photographs obtained with the InfraRed Array Camera (IRAC) aboard Spitzer. The image covers an area about two times that of a full moon. The mosaic is a composite of images obtained at mid-infrared wavelengths of 3.6 microns (blue), 4.5 microns (green), 5.8 microns (orange) and 8 microns (red). The brightest infrared cloud near the top center corresponds to DR21, which presumably contains a cluster of newly forming stars at a distance of 10,000 light-years.

    Protruding out from DR21 toward the bottom left of the image is a gaseous outflow (green), containing both carbon monoxide and molecular hydrogen. Data from the Spitzer spectrograph, which breaks light into its constituent individual wavelengths, indicate the presence of hot steam formed as the outflow heats the surrounding molecular gas. Outflows are physical signatures of processes that create supersonic beams, or jets, of gas. They are usually accompanied by discs of material around the new star, which likely contain the materials from which future planetary systems are formed. Additional newborn stars

  20. Dr. Wernher Von Braun leads a tour of the S-IC checkout area.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Eberhard Rees, Charles Schultze, James Webb, Elmer Staats, Comptroller General of the United States, and Dr. Wernher Von Braun tour the S-IC checkout area in the Marshall Space Flight Center quality lab.

  1. 21. Dr. Harrison E. Stroud poses in front of his ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    21. Dr. Harrison E. Stroud poses in front of his newly completed building at the northeast corner of Central Avenue and the alley north of Washington Street in about 1900 or 1901. In 1901, the building seen here was enlarged by the construction of an addition of similar design immediately to the north (left). Virtually the entire west elevation of the initial building is depicted in this view. Credit ADLAPR. - Stroud Building, 31-33 North Central Avenue, Phoenix, Maricopa County, AZ

  2. VEHICLE ASSEMBLY BUILDING [VAB] & TOPPING OFF CEREMONIES SPEAKER DR. DEBUS

    NASA Technical Reports Server (NTRS)

    1965-01-01

    Dr. Kurt H. Debus, KSC's first director, was a major speaker at the ceremonies ''topping off'' the Vehicle Assembly Building on April 14, 1965. A crawler-transporter is at the right. At the time of its completion, the 129 million cubic foot structure was the largest building in the world. Originally designed and built to accommodate the Saturn V/Apollo used in Project Apollo, the VAB was later modified for its role in the Space Shuttle program.

  3. 105-DR Large Sodium Fire Facility closure plan. Revision 1

    SciTech Connect

    Not Available

    1993-05-01

    The Hanford Site, located northwest of the city of Richland, Washington, houses reactors, chemical-separation systems, and related facilities used for the production of special nuclear materials, and activities associated with nuclear energy development. The 105-DR Large Sodium Fire Facility (LSFF), which was in operation from about 1972 to 1986, was a research laboratory that occupied the former ventilation supply room on the southwest side of the 105-DR Reactor facility. The LSFF was established to provide a means of investigating fire and safety aspects associated with large sodium or other metal alkali fires in the liquid metal fast breeder reactor (LMFBR) facilities. The 105-DR Reactor facility was designed and built in the 1950`s and is located in the 100-D Area of the Hanford Site. The building housed the 105-DR defense reactor, which was shut down in 1964. The LSFF was initially used only for engineering-scale alkali metal reaction studies. In addition, the Fusion Safety Support Studies program sponsored intermediate-size safety reaction tests in the LSFF with lithium and lithium lead compounds. The facility has also been used to store and treat alkali metal waste, therefore the LSFF is subject to the regulatory requirements for the storage and treatment of dangerous waste. Closure will be conducted pursuant to the requirements of the Washington Administrative Code (WAC) 173-303-610. This closure plan presents a description of the facility, the history of waste managed, and the procedures that will be followed to close the LSFF as an Alkali Metal Treatment Facility. No future use of the LSFF is expected.

  4. 8. View of DR 3 antenna showing lower front connector, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. View of DR 3 antenna showing lower front connector, third from left vertical member at first level above foundation level, showing small diameter turnbuckle stays, vertical member with flange connection, and various struts and connectors with antenna assembly in background. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  5. Dr. von Braun In Front of a Display of Missiles

    NASA Technical Reports Server (NTRS)

    1960-01-01

    In this photo, Director of the US Army Ballistic Missile Agency (ABMA) Development Operations Division, Dr. Wernher von Braun, is standing before a display of Army missiles celebrating ABMA's Fourth Open House. The missiles in the background include (left to right) a satellite on a Juno II shroud with a Nike Ajax pointing left in front of a Jupiter missile. The Lacrosse is in front of the Juno II. The Nike Hercules points skyward in front of the Juno II and the Redstone.

  6. 4. View of northerly DR 3 antenna looking north 35 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. View of northerly DR 3 antenna looking north 35 degrees west and showing radar scanner building no. 106 east face through antenna and partial view of satcom communication dome (attached to radar transmitter building 102) in left side of photograph. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  7. Of brain and bone: the unusual case of Dr. A.

    PubMed

    Narvid, J; Gorno-Tempini, M L; Slavotinek, A; Dearmond, S J; Cha, Y H; Miller, B L; Rankin, K

    2009-06-01

    Frontotemporal dementia (FTD) is a clinical syndrome characterized by progressive decline in social conduct and a focal pattern of frontal and temporal lobe damage. Its biological basis is still poorly understood but the focality of the brain degeneration provides a powerful model to study the cognitive and anatomical basis of social cognition. Here, we present Dr. A, a patient with a rare hereditary bone disease (hereditary multiple exostoses) and FTD (pathologically characterized as Pick's disease), who presented with a profound behavioral disturbance characterized by acquired sociopathy. We conducted a detailed genetic, pathological, neuroimaging and cognitive study, including a battery of tests designed to investigate Dr. A's abilities to understand emotional cues and to infer mental states and intentions to others (theory of mind). Dr. A's genetic profile suggests the possibility that a mutation causing hereditary multiple exostoses, Ext2, may play a role in the pattern of neurodegeneration in frontotemporal dementia since knockout mice deficient in the Ext gene family member, Ext1, show severe CNS defects including loss of olfactory bulbs and abnormally small cerebral cortex. Dr. A showed significant impairment in emotion comprehension, second order theory of mind, attribution of intentions, and empathy despite preserved general cognitive abilities. Voxel-based morphometry on structural MRI images showed significant atrophy in the medial and right orbital frontal and anterior temporal regions with sparing of dorsolateral frontal cortex. This case demonstrates that social and emotional dysfunction in FTD can be dissociated from preserved performance on classic executive functioning tasks. The specific pattern of anatomical damage shown by VBM emphasizes the importance of the network including the superior medial frontal gyrus as well as temporal polar areas, in regulation of social cognition and theory of mind. This case provides new evidence regarding the

  8. ORAC-DR: A generic data reduction pipeline infrastructure

    NASA Astrophysics Data System (ADS)

    Jenness, Tim; Economou, Frossie

    2015-03-01

    ORAC-DR is a general purpose data reduction pipeline system designed to be instrument and observatory agnostic. The pipeline works with instruments as varied as infrared integral field units, imaging arrays and spectrographs, and sub-millimeter heterodyne arrays and continuum cameras. This paper describes the architecture of the pipeline system and the implementation of the core infrastructure. We finish by discussing the lessons learned since the initial deployment of the pipeline system in the late 1990s.

  9. Dr. John Stack and other NASA Langley Research Center Visitors

    NASA Technical Reports Server (NTRS)

    2008-01-01

    Front Row, left to right: Mrs. Elsa Hoare and Major Philip L. Teed - staff members, Vickers-Armstrongs, Ltd., Weybridge, England: Dr. Barnes Wallis - Chief of Aeronautical Research, Vicers-Armstrong, Ltd., Weybridge, England. Back Row, left to right: Norman W. Boorer and Cecil W. Hayes - Staff members, Vickers-Armstrongs, Ltd., Weybridge, England; John R. Christie - Ministry of Supply, London, England; Philip A. Hufton - Chief Supt., Royal Aircraft Establishment, Bedford, England; Lindsey I. Turner, Jr. - Langley Research Center. Photographed November 13, 1958.

  10. Dr. Lytle Adams' incendiary "bat bomb" of World War II.

    PubMed

    Christen, Arden G; Christen, Joan A

    2004-11-01

    On December 7, 1941, a 60-year old dentist from Irwin, Pennsylvania, Dr. Lytle S. Adams, was driving home from a vacation at Carlsbad Caverns in New Mexico. Hours earlier, he had been gripped with amazement as he witnessed millions of bats exiting the caves of Carlsbad. Listening to his car radio on his return trip, he was shocked to hear that Japan had just attacked Pearl Harbor. Dr. Adams, outraged over this travesty, began to mentally construct a plan for U.S. retaliation. As his thoughts returned to the countless bats that had awed him, he formed a tentative plan: millions of these small, flying mammals could be connected to tiny, time-fused incendiary bombs, and then released to land on the flimsily constructed structures which dotted the cities of Japan. Within a few minutes, the bombs would explode and enflame the entire urban areas. He postulated that these immeasurable numbers of fires, spreading their devastation over such vast areas within Japanese cities would result in the enemy's speedy surrender. This article documents the futile efforts of Dr. Adams, his team and the U.S. government to develop and employ an effective, incendiary bat bomb. The recently developed atom bomb, a far more deadly weapon was used in its place. PMID:15666497

  11. Dr. Lytle Adams' incendiary "bat bomb" of World War II.

    PubMed

    Christen, Arden G; Christen, Joan A

    2004-11-01

    On December 7, 1941, a 60-year old dentist from Irwin, Pennsylvania, Dr. Lytle S. Adams, was driving home from a vacation at Carlsbad Caverns in New Mexico. Hours earlier, he had been gripped with amazement as he witnessed millions of bats exiting the caves of Carlsbad. Listening to his car radio on his return trip, he was shocked to hear that Japan had just attacked Pearl Harbor. Dr. Adams, outraged over this travesty, began to mentally construct a plan for U.S. retaliation. As his thoughts returned to the countless bats that had awed him, he formed a tentative plan: millions of these small, flying mammals could be connected to tiny, time-fused incendiary bombs, and then released to land on the flimsily constructed structures which dotted the cities of Japan. Within a few minutes, the bombs would explode and enflame the entire urban areas. He postulated that these immeasurable numbers of fires, spreading their devastation over such vast areas within Japanese cities would result in the enemy's speedy surrender. This article documents the futile efforts of Dr. Adams, his team and the U.S. government to develop and employ an effective, incendiary bat bomb. The recently developed atom bomb, a far more deadly weapon was used in its place.

  12. Dr.LiTHO: a development and research lithography simulator

    NASA Astrophysics Data System (ADS)

    Fühner, Tim; Schnattinger, Thomas; Ardelean, Gheorghe; Erdmann, Andreas

    2007-03-01

    This paper introduces Dr.LiTHO, a research and development oriented lithography simulation environment developed at Fraunhofer IISB to flexibly integrate our simulation models into one coherent platform. We propose a light-weight approach to a lithography simulation environment: The use of a scripting (batch) language as an integration platform. Out of the great variety of different scripting languages, Python proved superior in many ways: It exhibits a good-natured learning-curve, it is efficient, available on virtually any platform, and provides sophisticated integration mechanisms for existing programs. In this paper, we will describe the steps, required to provide Python bindings for existing programs and to finally generate an integrated simulation environment. In addition, we will give a short introduction into selected software design demands associated with the development of such a framework. We will especially focus on testing and (both technical and user-oriented) documentation issues. Dr.LiTHO Python files contain not only all simulation parameter settings but also the simulation flow, providing maximum flexibility. In addition to relatively simple batch jobs, repetitive tasks can be pooled in libraries. And as Python is a full-blown programming language, users can add virtually any functionality, which is especially useful in the scope of simulation studies or optimization tasks, that often require masses of evaluations. Furthermore, we will give a short overview of the numerous existing Python packages. Several examples demonstrate the feasibility and productiveness of integrating Python packages into custom Dr.LiTHO scripts.

  13. Early growth response-1 is a regulator of DR5-induced apoptosis in colon cancer cells

    PubMed Central

    Mahalingam, D; Natoni, A; Keane, M; Samali, A; Szegezdi, E

    2010-01-01

    Background: Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) induces tumour cell apoptosis by binding to death receptor 4 (DR4) and DR5. DR4 and DR5 activation however can also induce inflammatory and pro-survival signalling. It is not known how these different cellular responses are regulated and what the individual role of DR4 vs DR5 is in these processes. Methods: DNA microarray study was carried out to identify genes differentially expressed after DR4 and DR5 activation. RT–PCR and western blotting was used to examine the expression of early growth response gene-1 (Egr-1) and the proteins of the TRAIL signalling pathway. The function of Egr-1 was studied by siRNA-mediated knockdown and overexpression of a dominant-negative version of Egr-1. Results: We show that the immediate early gene, Egr-1, regulates TRAIL sensitivity. Egr-1 is constitutively expressed in colon cancer cells and further induced upon activation of DR4 or DR5. Our results also show that DR4 mediates a type II, mitochondrion-dependent apoptotic pathway, whereas DR5 induces a mitochondrion-independent, type I apoptosis in HCT15 colon carcinoma cells. Egr-1 drives c-FLIP expression and the short splice variant of c-FLIP (c-FLIPS) specifically inhibits DR5 activation. Conclusion: Selective knockdown of c-FLIPS sensitises cells to DR5-induced but not DR4-induced apoptosis and Egr-1 exerts an effect as an inhibitor of the DR5-induced apoptotic pathway, possibly by regulating the expression of c-FLIPS. PMID:20087343

  14. Dr. Wernher Von Braun greeting dignitaries at the Redstone Arsenal airfield.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. George E. Mueller, center, associate administrator for manned space flight, is flanked by Dr. Wernher Von Braun, left, and Dr. Eberhard Rees at the Redstone Arsenal airstrip. the associate adminstrator was making his annual staff visit to the Marshall Space Flight Center.

  15. Enhancing Price Response Programs through Auto-DR: California's 2007 Implementation Experience

    SciTech Connect

    Kiliccote, Sila; Wikler, Greg; Chiu, Albert; Piette, Mary Ann; Kiliccote, Sila; Hennage, Dan; Thomas, Chuck

    2007-12-18

    This paper describes automated demand response (Auto-DR) activities, an innovative effort in California to ensure that DR programs produce effective and sustainable impacts. Through the application of automation and communication technologies coupled with well-designed incentives and DR programs such as Critical Peak Pricing (CPP) and Demand Bidding (DBP), Auto-DR is opening up the opportunity for many different types of buildings to effectively participate in DR programs. We present the results of Auto-DR implementation efforts by the three California investor-owned utilities for the Summer of 2007. The presentation emphasizes Pacific Gas and Electric Company's (PG&E) Auto-DR efforts, which represents the largest in the state. PG&E's goal was to recruit, install, test and operate 15 megawatts of Auto-DR system capability. We describe the unique delivery approaches, including optimizing the utility incentive structures designed to foster an Auto-DR service provider community. We also show how PG&E's Critical Peak Pricing (CPP) and Demand Bidding (DBP) options were called and executed under the automation platform. Finally, we show the results of the Auto-DR systems installed and operational during 2007, which surpassed PG&E's Auto-DR goals. Auto-DR is being implemented by a multi-disciplinary team including the California Investor Owned Utilities (IOUs), energy consultants, energy management control system vendors, the Lawrence Berkeley National Laboratory (LBNL), and the California Energy Commission (CEC).

  16. VizieR Online Data Catalog: LAMOST DR2 white dwarfs (Guo+, 2015)

    NASA Astrophysics Data System (ADS)

    Guo, J.; Zhao, J.; Tziamtzis, A.; Liu, J.; Li, L.; Zhang, Y.; Hou, Y.; Wang, Y.

    2016-07-01

    LAMOST DR1 released 2204860 spectra, which included 717660 objects from the pilot survey, observed from 2011 October to 2012 June and 1487200 objects from the regular survey from 2012 September to 2013 June. DR2, which included DR1, released 1588 746 new spectra during the second year in 2014. (4 data files).

  17. Prospective HLA-DR matching in cadaveric renal transplants: a single center study.

    PubMed

    Mendez, R; Iwaki, Y; Mendez, R; Bogaard, T; Self, B

    1983-03-01

    We reviewed 77 potential cadaveric allograft recipients who had undergone prospective HLA-A and B locus and HLA-DR antigen identification. Matching was accomplished, giving first priority to HLA-DR compatibility and relying on HLA-A and B antigen matching only in situations of total HLA-DR incompatibility. Complete HLA-DR identification occurred in 56 per cent of all patients. There were 15 patients (19.5 per cent) who received a 2/2 HLA-DR perfect match, with 86.7 plus or minus 8.8 per cent 1-year actuarial graft survival, and 41 (53 per cent) who received a 1/2 HLA-DR match, with 58.2 plus or minus 7.8 per cent 1-year actual allograft survival. Finally, 21 patients (27 per cent) received a 0/2 HLA-DR match, with 64.9 plus or minus 10.7 per cent actual survival. These results and their mirrored mismatching results showed statistically significant allograft success in only the HLA-DR 2/2 matches. Matching for HLA 2 DR donors proved a statistically significant success over the other HLA-DR allograft matches and the older controversial matching system based on HLA-A and B locus antigens. The restricted gene polymorphism of the HLA-DR systems allows for a relatively high percentage of perfect HLA-DR matches.

  18. HLA-DR9 and DR14 are associated with the allopurinol-induced hypersensitivity in hematologic malignancy.

    PubMed

    Jung, Jae-Woo; Kim, Ju-Young; Yoon, Sung-Soo; Cho, Sang-Heon; Park, Seon-Yang; Kang, Hye-Ryun

    2014-01-01

    Allopurinol, a widely used urate-lowering agent, is a leading cause of severe cutaneous adverse reactions (SCARs), especially in patients with HLA-B*58:01. Despite its routine use for the prevention of tumor lysis-related hyperuricemia prior to chemotherapy, the risk of allopurinol-induced hypersensitivity has not been investigated in patients with hematologic malignancies. This retrospective cohort study was conducted to investigate the incidence and risk factors of allopurinol-induced hypersensitivity in patients at least 18 years of age with hematologic malignancies. We reviewed 463 patients who had ever taken allopurinol for the prevention of hyperuricemia prior to chemotherapy and had undergone serologic HLA typing as a pre-transplant evaluation from January 2000 to May 2010. Thirteen (2.8%) patients experienced maculopapular eruptions (MPE) and none experienced SCARs. Among subtypes of underlying hematologic malignancies, percentage of chronic myeloid leukemia was significantly higher in the allopurinol hypersensitivity group compared with the tolerant group (23.1% (3/13) vs. 5.9% (26/440), P = 0.044). According to HLA subtypes, the incidence of allopurinol-induced MPE was 4.0% in HLA-B58 (+) patients (2/50) and 2.7% in HLA-B58 (-) patients (11/403) but this difference was statistically insignificant. In contrast to HLA-B58, the frequencies of DR9 and DR14 were significantly higher in the allopurinol-induced MPE group compared with the allopurinol tolerant group (38.5% (5/13) vs. 13.6% (53/443), P = 0.019, and 38.5% (5/13) vs. 15.6% (41/440), P = 0.038, respectively). In conclusion, HLA-DR9 and DR14, but not HLA-B58, are associated with hypersensitivity reaction by allopurinol when administered in patients with hematologic malignancy prior to chemotherapy.

  19. Human immune responsiveness to Lolium perenne pollen allergen Lol p III (rye III) is associated with HLA-DR3 and DR5.

    PubMed

    Ansari, A A; Freidhoff, L R; Meyers, D A; Bias, W B; Marsh, D G

    1989-05-01

    A well-characterized allergen of Lolium perenne (perennial rye grass) pollen, Lol p III, has been used as a model antigen to study the genetic control of the human immune response. Associations between HLA type and IgE or IgG antibody (Ab) responsiveness to Lol p III were studied in two groups of skin-test-positive Caucasoid adults (N = 135 and 67). We found by nonparametric and parametric analyses that immune responsiveness to Lol p III was significantly associated with HLA-DR3 and DR5. No association was found between any DQ type and immune responsiveness to Lol p III. Geometric mean IgE or IgG Ab levels to Lol p III were not different between B8+, DR3+ subjects and B8-, DR3+ subjects, showing that HLA-B8 had no influence on the association. Lol p III IgG Ab data obtained on subjects after grass antigen immunotherapy showed that 100% of DR3 subjects and 100% of DR5 subjects were Ab+. A comparison of all the available protein sequences of DRB gene products showed that the first hypervariable region of DR3 and DR5 (and DRw6), and no other region, contains the sequence Glu9-Tyr-Ser-Thr-Ser13. Our observations are consistent with the possibility that immune responsiveness to the allergen Lol p III is associated with this amino acid sequence in the first hypervariable region of the DR beta 1 polypeptide chain.

  20. Dynamic star formation in the massive DR21 filament

    NASA Astrophysics Data System (ADS)

    Schneider, N.; Csengeri, T.; Bontemps, S.; Motte, F.; Simon, R.; Hennebelle, P.; Federrath, C.; Klessen, R.

    2010-09-01

    Context. The formation of massive stars is a highly complex process in which it is unclear whether the star-forming gas is in global gravitational collapse or an equilibrium state supported by turbulence and/or magnetic fields. In addition, magnetic fields may play a decisive role in the star-formation process since they influence the efficiency of gas infall onto the protostar. Aims: By studying one of the most massive and dense star-forming regions in the Galaxy at a distance of less than 3 kpc, i.e. the filament containing the well-known sources DR21 and DR21(OH), we attempt to obtain observational evidence to help us to discriminate between these two views. Methods: We use molecular line data from our 13CO 1 to 0, CS 2 to 1, and N2H+ 1 to 0 survey of the Cygnus X region obtained with the FCRAO and high-angular resolution observations in isotopomeric lines of CO, CS, HCO+, N2H+, and H2CO, obtained with the IRAM 30 m telescope, to investigate the distribution of the different phases of molecular gas. Gravitational infall is identified by the presence of inverse P Cygni profiles that are detected in optically thick lines, while the optically thinner isotopomers are found to reach a peak in the self-absorption gap. Results: We observe a complex velocity field and velocity dispersion in the DR21 filament in which regions of the highest column-density, i.e., dense cores, have a lower velocity dispersion than the surrounding gas and velocity gradients that are not (only) due to rotation. Infall signatures in optically thick line profiles of HCO+ and 12CO are observed along and across the whole DR21 filament. By modelling the observed spectra, we obtain a typical infall speed of 0.6 km s-1 and mass accretion rates of the order of a few 10-3 M_⊙ yr-1 for the two main clumps constituting the filament. These massive clumps (4900 and 3300 M_⊙ at densities of around 105 cm-3 within 1 pc diameter) are both gravitationally contracting (with free-fall times much shorter

  1. DR Resources for Energy and Ancillary Services in the West (Presentation)

    SciTech Connect

    Hummon, M.; Kiliccote, S.

    2014-04-01

    Demand response (DR) resources present a potentially important source of grid flexibility however, DR in grid models is limited by data availability and modeling complexity. This presentation focuses on the co-optimization of DR resources to provide energy and ancillary services in a production cost model of the Colorado "test system". We assume each DR resource can provide energy services by either shedding load or shifting its use between different times, as well as operating reserves: frequency regulation, contingency reserve, and flexibility (or ramping) reserve. There are significant variations in the availabilities of different types of DR resources, which affect both the operational savings as well as the revenue for each DR resource. The results presented include the system-wide avoided fuel and generator start-up costs as well as the composite revenue for each DR resource by energy and operating reserves.

  2. Regulation of human peripheral blood monocyte DR antigen expression in vitro by lymphokines and recombinant interferons.

    PubMed Central

    Sztein, M B; Steeg, P S; Johnson, H M; Oppenheim, J J

    1984-01-01

    The in vitro regulation of adult human monocyte DR antigen expression was studied. Normally about 75% of freshly obtained human peripheral blood monocytes express DR antigens as determined by anti-DR and complement-mediated cytotoxicity assays. DR expression on monocytes in unfractionated peripheral blood mononuclear cell cultures persisted to variable degrees for up to 5 d of incubation. However, when the mononuclear cells were thoroughly depleted of nonadherent cells, cultured monocytes consistently exhibited progressively decreased DR expression over 2-5 d of incubation. Readdition of nonadherent cells to the adherent cell population prevented or delayed this decrease in monocyte DR antigen expression. Thus, monocyte DR expression diminished markedly during in vitro incubation; however, the presence of nonadherent cells somehow interfered with this process. In other experiments, peripheral adherent monocytes, which had been cultured for 2-3 d to reduce their DR expression, could be induced to reexpress DR antigens after 2 d of incubation with unpurified lymphokine-containing culture supernatants, recombinant human interferon-alpha, or recombinant human gamma interferon (IFN-gamma). The reinduction of DR expression on human monocytes by lymphokines was abrogated by an antiserum produced to the synthetic N-terminal amino acids of human IFN-gamma, indicating that IFN-gamma is the active mediator in the lymphokine-containing preparations. Monocytes cultured with lymphokines or recombinant interferons also could initiate a significantly greater mixed lymphocyte response than control monocytes. Thus, IFN-gamma-containing lymphokines and recombinant interferons are required to induce human monocyte DR expression and accessory cell capacity in vitro, since in their absence monocytes become DR antigen-deficient. Finally, incubation of unfractionated human mononuclear cells with anti-human IFN-gamma also promoted the loss of monocyte DR expression. These findings suggest

  3. [DR image denoising based on Laplace-Impact mixture model].

    PubMed

    Feng, Guo-Dong; He, Xiang-Bin; Zhou, He-Qin

    2009-07-01

    A novel DR image denoising algorithm based on Laplace-Impact mixture model in dual-tree complex wavelet domain is proposed in this paper. It uses local variance to build probability density function of Laplace-Impact model fitted to the distribution of high-frequency subband coefficients well. Within Laplace-Impact framework, this paper describes a novel method for image denoising based on designing minimum mean squared error (MMSE) estimators, which relies on strong correlation between amplitudes of nearby coefficients. The experimental results show that the algorithm proposed in this paper outperforms several state-of-art denoising methods such as Bayes least squared Gaussian scale mixture and Laplace prior.

  4. Halo Stream candidates in the LAMOST DR2

    NASA Astrophysics Data System (ADS)

    Zhao, Jingkun

    2015-08-01

    We have detected eight stellar halo stream candidates in the solar neighborhood using a sample including 64,819 FGK metal-poor ([Fe/H] < -0.7) dwarfs extracted from the cross-match among the LAMOST DR2, WISE, 2MASS and PPMXL catalogues. With the strategy of halo stream detection in Klement et al, several significant ‘phase-space overdensi- ties” of stars on very similar orbits are identified. Three structures are known previously. Five new halo stream candidates are also found. The kinematics and metallicity of these stream candidates are then analyzed. Detailed element abundance are needed to better know the ori-gin of these streams.

  5. STS-71 Payload Commander Dr. Ellen S. Baker suits up

    NASA Technical Reports Server (NTRS)

    1995-01-01

    STS-71 Payload Commander Dr. Ellen S. Baker is assisted by a suit technician as she dons her launch/entry suit in the Operations and Checkout Building. Her third spaceflight will be an historic one for Baker, a medical doctor, as she oversees the series of scientific investigations that will be conducted during the first docking of the U.S. Space Shuttle to the Russian Space Station Mir. Baker and six fellow crew members -- four Americans and two Russian cosmonauts -- will shortly depart for Launch Pad 39A, where the Space Shuttle Atlantis awaits liftoff during a 10- minute launch window opening at 3:32 p.m. EDT.

  6. STS-72 Mission Specialist Dr. Daniel T. Barry suits up

    NASA Technical Reports Server (NTRS)

    1996-01-01

    Looking elated at the prospect of his upcoming spaceflight, STS- 72 Mission Specialist Dr. Daniel T. Barry dons his launch/entry suit in the Operations and Checkout Building with assistance from a suit technician. The trip into space will be the first for Barry, a medical doctor who also has a Ph.D. in electrical engineering. He and five fellow crew members will soon depart for Launch Pad 39, where the Space Shuttle Endeavour is undergoing final preparations for liftoff during an approximately 49-minute window opening at about 4:18 am EST, January 11.

  7. Dr. Christopher Kraft looks over packaged 'parasol' in bldg 10

    NASA Technical Reports Server (NTRS)

    1973-01-01

    Dr. Christopher C. Kraft J. (left), JSC Director, and George A Post, JSC Crew Systems Division, look over the packaged 'parasol' during fabrication and checkout of the umbrella-like mechanical device in the Technical Services shop in bldg 10 at JSC. The 'parasol' is designed to fit into the T027 experiment photometer canister. The canopy portion of the 'parasol' measures 24 feet by 22 feet. The 'parasol' is one of several sunscreen possibilities being considered for use in shading the overheated Skylab 1 Orbital Workshop.

  8. Rapidity: The Special Relativity Work of Dr. Vladimir Karapetoff

    NASA Astrophysics Data System (ADS)

    Carter, Hamilton

    2014-03-01

    Between 1924 and 1944 Dr. Vladimir Karapetoff, a professor in the electrical engineering department of Cornell University, authored 11 papers on the topic of special relativity. While his initial papers focused on the then popular oblique angle treatment of special relativity, he soon became a vocal proponent of performing special relativistic calculations using rapidity, a technique that emphasizes the hyperbolic geometric nature of Minkowski space-time. While rapidity has fallen out of usage with the exception of a specialized dialect within particle physics, it offers interesting technical and pedagogical perspectives on the geometrical nature of space-time not evident in the present day relativistic parlance.

  9. 89. View of DR 2 antenna (structure no. 736) at ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    89. View of DR 2 antenna (structure no. 736) at 65 percent completion showing erection process. Antenna system designed and factory construction by D.S. Kennedy & Company., Comasset, MA, 1958. Note scanner radar building in background. Official photograph BMEWS Project by unknown photographer, 11 July, 1960, Photographic Services, Riverton, NJ, BMEWS, clear as negative no. A-824. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  10. The Chicago Board of Education Desegregation Policies and Practices [1975-1985]: A Historical Examination of the Administrations of Superintendents Dr. Joseph P. Hannon and Dr. Ruth Love

    ERIC Educational Resources Information Center

    James, Michael

    2009-01-01

    The purpose of this study will be to examine the policies and practices of two distinguished superintendents of the Chicago Public Schools: Dr. Joseph P. Hannon and the first African American female Superintendent Dr. Ruth Love. Hannon's four year administration extended from 1975 through 1979. Love's administration encompassed the years 1980…

  11. Clinical and molecular studies in full trisomy 22: Further delineation of the phenotype and review of the literature. Reply to Dr. Robinson and Dr. Kalousek

    SciTech Connect

    Bacino, C.A.; Graham, J.M. Jr.

    1996-03-01

    This {open_quotes}Letter to the Editor{close_quotes} responds to the comments by Dr. Robinson and Dr. Kalousek regarding the implications of meiotic versus somatic chromosomal aberrations. The survival time of the patient may depend on the detection of mosicism; the discussion of the existence of full trisomy 22 remains controversial. 2 refs.

  12. Pathogenesis of Human Diffusely Adhering Escherichia coli Expressing Afa/Dr Adhesins (Afa/Dr DAEC): Current Insights and Future Challenges

    PubMed Central

    2014-01-01

    SUMMARY The pathogenicity and clinical pertinence of diffusely adhering Escherichia coli expressing the Afa/Dr adhesins (Afa/Dr DAEC) in urinary tract infections (UTIs) and pregnancy complications are well established. In contrast, the implication of intestinal Afa/Dr DAEC in diarrhea is still under debate. These strains are age dependently involved in diarrhea in children, are apparently not involved in diarrhea in adults, and can also be asymptomatic intestinal microbiota strains in children and adult. This comprehensive review analyzes the epidemiology and diagnosis and highlights recent progress which has improved the understanding of Afa/Dr DAEC pathogenesis. Here, I summarize the roles of Afa/Dr DAEC virulence factors, including Afa/Dr adhesins, flagella, Sat toxin, and pks island products, in the development of specific mechanisms of pathogenicity. In intestinal epithelial polarized cells, the Afa/Dr adhesins trigger cell membrane receptor clustering and activation of the linked cell signaling pathways, promote structural and functional cell lesions and injuries in intestinal barrier, induce proinflammatory responses, create angiogenesis, instigate epithelial-mesenchymal transition-like events, and lead to pks-dependent DNA damage. UTI-associated Afa/Dr DAEC strains, following adhesin-membrane receptor cell interactions and activation of associated lipid raft-dependent cell signaling pathways, internalize in a microtubule-dependent manner within urinary tract epithelial cells, develop a particular intracellular lifestyle, and trigger a toxin-dependent cell detachment. In response to Afa/Dr DAEC infection, the host epithelial cells generate antibacterial defense responses. Finally, I discuss a hypothetical role of intestinal Afa/Dr DAEC strains that can act as “silent pathogens” with the capacity to emerge as “pathobionts” for the development of inflammatory bowel disease and intestinal carcinogenesis. PMID:25278576

  13. M-giant star candidates identified in LAMOST DR 1

    NASA Astrophysics Data System (ADS)

    Zhong, Jing; Lépine, Sébastien; Li, Jing; Chen, Li; Hou, Jin-Liang; Yang, Ming; Li, Guang-Wei; Zhang, Yong; Hou, Yong-Hui

    2015-08-01

    We perform a discrimination procedure with the spectral index diagram of TiO5 and CaH2+CaH3 to separate M giants from M dwarfs. Using the M giant spectra identified from LAMOST DR1 with high signal-to-noise ratio, we have successfully assembled a set of M giant templates, which show more reliable spectral features. Combining with the M dwarf/subdwarf templates in Zhong et al., we present an extended library of M-type templates which includes not only M dwarfs with a well-defined temperature and metallicity grid but also M giants with subtypes from M0 to M6. Then, the template-fitting algorithm is used to automatically identify and classify M giant stars from LAMOST DR1. The resulting catalog of M giant stars is cross-matched with 2MASS JHKs and WISE W1/W2 infrared photometry. In addition, we calculated the heliocentric radial velocity of all M giant stars by using the cross-correlation method with the template spectrum in a zero-velocity rest frame. Using the relationship between the absolute infrared magnitude MJ and our classified spectroscopic subtype, we derived the spectroscopic distance of M giants with uncertainties of about 40%. A catalog of 8639 M giants is provided. As an additional result of this analysis, we also present a catalog of 101 690 M dwarfs/subdwarfs which are processed by our classification pipeline.

  14. CENSUS OF BLUE STARS IN SDSS DR8

    SciTech Connect

    Scibelli, Samantha; Newberg, Heidi Jo; Carlin, Jeffrey L.; Yanny, Brian

    2015-01-01

    We present a census of the 12,060 spectra of blue objects ((g – r){sub 0} < –0.25) in the Sloan Digital Sky Survey (SDSS) Data Release 8 (DR8). As part of the data release, all of the spectra were cross-correlated with 48 template spectra of stars, galaxies, and QSOs to determine the best match. We compared the blue spectra by eye to the templates assigned in SDSS DR8. 10,856 of the objects matched their assigned template, 170 could not be classified due to low signal-to-noise ratio, and 1034 were given new classifications. We identify 7458 DA white dwarfs, 1145 DB white dwarfs, 273 rarer white dwarfs (including carbon, DZ, DQ, and magnetic), 294 subdwarf O stars, 648 subdwarf B stars, 679 blue horizontal branch stars, 1026 blue stragglers, 13 cataclysmic variables, 129 white dwarf-M dwarf binaries, 36 objects with spectra similar to DO white dwarfs, 179, quasi-stellar objects (QSOs), and 10 galaxies. We provide two tables of these objects, sample spectra that match the templates, figures showing all of the spectra that were grouped by eye, and diagnostic plots that show the positions, colors, apparent magnitudes, proper motions, etc., for each classification. Future surveys will be able to use templates similar to stars in each of the classes we identify to automatically classify blue stars, including rare types.

  15. PREFACE: Eighth International Conference on Dissociative Recombination (DR2010)

    NASA Astrophysics Data System (ADS)

    Guberman, Steven L.; Orel, Ann E.

    2011-07-01

    In dissociative recombination (DR), a molecular ion captures an electron and falls apart. One might initially conclude that this process is relatively simple. However, a review of the DR literature over the past 60 years, since the pioneering papers of Sir David Bates [1], shows that the study of DR has proved to be highly challenging for both theorists and experimentalists. Both this challenge and the ubiquitous importance of the process have made its study rewarding, endlessly interesting, and full of surprises. DR is fundamentally the interaction of an electronic continuum with a vibrational continuum often connected by quasibound intermediate states. Autoionization in the first continuum competes with dissociation in the second. DR occurs at the total energy of an ion plus a free electron and is in the same region as vibrationally excited Rydberg states and other neutral superexcited states. All these states interact with each other prior to dissociation, forming a complex that controls the quantum yields of products. The complexity of the process has required both innovation and ingenuity on the part of both theorists and experimentalists. Over the years, it has become apparent that in order to compare theoretical and experimental results, the experiments must identify the electronic, vibrational and for low mass ions, the rotational state. The traditional disagreement between theoretical and experimental results has been due, in part, to the sensitivity of DR cross sections and rate constants to the state of the recombining ion. Great progress has been made in recent years in both flowing afterglow and storage ring experiments aimed at reducing this uncertainty. The latest advances and insights in theory and experiment were the topics of the Eighth International Conference on Dissociative Recombination held at the Granlibakken Lodge at Lake, Tahoe, California, 16-20 August 2010. The conference was part of a series of conferences on DR that started at Chateau

  16. Abnormal urothelial HLA-DR expression in interstitial cystitis.

    PubMed

    Christmas, T J; Bottazzo, G F

    1992-03-01

    Interstitial cystitis is a chronic inflammatory disorder of the urinary bladder that predominantly afflicts middle-age women. The end stage of the disease is ulceration of the urothelium, the so-called Hunner's ulcer. The aetiology of interstitial cystitis remains obscure. We have studied bladder biopsies from 22 cases of interstitial cystitis and control groups consisting of six cases of bacterial cystitis and eight healthy women. Indirect immunofluorescence was performed on the biopsies using murine MoAbs to human HLA class I molecules, and class II molecules, HLA-DP, HLA-DQ and HLA-DR. In interstitial cystitis, bacterial cystitis and normal controls most cells expressed HLA class I products. In six cases of interstitial cystitis and one case of bacterial cystitis there was evidence of HLA class I hyperexpression. In normal bladder and bacterial cystitis HLA class II expression was restricted to submucosal dendritic cells, Langerhans cells macrophages, vascular endothelial cells and activated lymphocytes. All but two cases of interstitial cystitis showed surface expression of HLA-DR (but not HLA-DP or DQ). In all cases of interstitial cystitis there was an increase in the numbers of macrophages, activated lymphocytes and vascular endothelial cells expressing HLA class II molecules within the submucosa. These findings provide further evidence for the importance of inappropriate HLA molecule expression in a disease suspected of having an autoimmune pathogenesis and where cellular autoimmune mechanisms play a decisive role in the destruction of the target cells--the bladder urothelium.

  17. Alloantiserum recognizing a DQw2 split which is associated with DR3.

    PubMed

    Flesch, B; Neppert, J; Ziegler, P; Achtert, G

    1991-01-01

    A typing serum MUE 38539 II, was found to recognize a DR3-associated split of DQw2. In cytotoxicity tests, MUE 38539 II yielded positive test results with B lymphocytes but not with monocytes of DR3-positive cell donors. This was in contrast to other typing reagents for DR3 that react with B lymphocytes as well as monocytes. Lymphocytotoxicity tests using MUE 38539 II were negative with DR7- and DQw2-positive cells. The assumption that the serum recognizes a DR3-associated split of DQw2, and not DR3 itself, was confirmed by the lack of reactivity with a DQw4- and DR3-positive lymphoblastoid cell line (RSH). The assumption was also corroborated using reagents from a family in which DR3 and DQw2 were not found in the usually described linkage. In two lines, DR3 was associated with DQw- (2707 and 2710), and in the cell line 2704, DQw2 was associated with DRw-. The serum MUE 38539 II was exclusively cytotoxic with lymphoblastoid cell lines from those family members who were positive for DQw2, independently of the DR3 antigens of the cells. PMID:2031339

  18. Examination of HLA-DR4 as a severity marker for rheumatoid arthritis in Greek patients.

    PubMed Central

    Boki, K A; Drosos, A A; Tzioufas, A G; Lanchbury, J S; Panayi, G S; Moutsopoulos, H M

    1993-01-01

    OBJECTIVES--Previous reports have shown that HLA-DR4 may be a severity marker for rheumatoid arthritis (RA) in patients of northern European origin. The aim of the present study was to investigate this relation in Greek patients with RA, as RA in Greece differs from the RA described previously on clinical, serological, and immunological grounds. METHODS--Eighty four patients were studied in whom HLA-DR typing was performed by restriction fragment length polymorphism and the subtypes of HLA-DR4 were determined by the polymerase chain reaction. The absence or presence of HLA-DR4 and its subtypes was correlated with the clinical and serological characteristics of the patients and with the side effects due to disease modifying drugs. RESULTS--Twenty one of the 84 (25%) patients with RA were DR4+. There was no difference between the DR4+ and DR4-patients with respect to duration of disease, severity of arthritis, functional grade, and joint erosion score. The DR4+ group were more likely to have side effects due to disease modifying drugs (43%) than DR4- patients (36%), but this difference was not statistically significant. DR4-patients had more extra-articular manifestations, including Sjögren's syndrome (47 v 19%). Analysis of the DR4 subtypes showed that Dw15 was the most common variant (9/21 patients; 43%). There was no statistical difference in the clinical manifestations among patients with different DR4 subtypes. The same was also true when the clinical picture was correlated with the 'shared RA epitope' (QKRAA/QRRAA/RRRAA), which is common to all HLA-DRB1 alleles positively associated with RA. CONCLUSIONS--These results suggest that HLA-DR4 is not a severity marker in Greek patients with RA and further indicate differences in the clinical expression of RA in Greece. PMID:8102226

  19. [Story of three SS dentists during World War II: Pr Hugo Blaschke, Dr Hermann Pook and Dr Willy Frank].

    PubMed

    Riaud, Xavier

    2006-12-01

    This story of three SS dentists shows very clearly that the medical code of ethics, under a totalitarian regime, ends where ideology begins. Professor Hugo Blaschke provided dental care to the most eminent Nazi leaders, but he also was the senior SS dentist. He was in charge of dental care in the Waffen-SS, and therefore, he had responsibility for the stocks of dental gold collected from the mouths of those who died in the concentration camps, in order to make dentures for his soldiers. Dr Hermann Pook was the dentist in charge of all the other dentists practising in the concentration camps. He was responsible for gathering statistics on the dental care provided for prisoners in the camps. His instructions were very clear: "No conservation or restorative treatment. Only extractions, and with no anaesthesia!" He was also in charge of gathering the gold that was collected in the camps, for the financial department of the SS. Dr Willy Frank, an Auschwitz dentist, took part in the selection of some of the convoys for the gas chambers. His participation in the collection of gold from the mouths of the dead was also established. These three men were sentenced to prison for War Crimes and Crimes against Humanity.

  20. [Story of three SS dentists during World War II: Pr Hugo Blaschke, Dr Hermann Pook and Dr Willy Frank].

    PubMed

    Riaud, Xavier

    2006-12-01

    This story of three SS dentists shows very clearly that the medical code of ethics, under a totalitarian regime, ends where ideology begins. Professor Hugo Blaschke provided dental care to the most eminent Nazi leaders, but he also was the senior SS dentist. He was in charge of dental care in the Waffen-SS, and therefore, he had responsibility for the stocks of dental gold collected from the mouths of those who died in the concentration camps, in order to make dentures for his soldiers. Dr Hermann Pook was the dentist in charge of all the other dentists practising in the concentration camps. He was responsible for gathering statistics on the dental care provided for prisoners in the camps. His instructions were very clear: "No conservation or restorative treatment. Only extractions, and with no anaesthesia!" He was also in charge of gathering the gold that was collected in the camps, for the financial department of the SS. Dr Willy Frank, an Auschwitz dentist, took part in the selection of some of the convoys for the gas chambers. His participation in the collection of gold from the mouths of the dead was also established. These three men were sentenced to prison for War Crimes and Crimes against Humanity. PMID:17575817

  1. [Portrait of Dr Milenko Petrović (1884-1950)].

    PubMed

    Kljaić, Leposava; Borota, Radoslav

    2008-01-01

    Dr Milenko Petrović was one of the very distinguished physicians in the history of Sombor city, who significantly contributed to the development of health care in Voivodina. His father Dimitrije was a professor in the High Teacher-training School in Sombor, recognized writer and politician of his epoch. He was born in Sombor in 1884, where he was educated and finished grammar school. For medical studies he moved to Budapest as a boarder of the famous Tekelianum, and graduated in 1908. He started specialisation in surgery, but being a great patriot he voluntarily recruited in the Serbian army to fight in Balkan liberation wars against Turkey. For his excellent work as a war surgeon he obtained many recognitions. After completing specialization in surgery in Debrecin, he returned to his native city Sombor, where he intended to practice as a physician, but because af the outbreak of the first world he was mobilized and sent to the front in Galicia. After the war he again returned to Sombor where he was immediatelly nominated for the main county physician and then begins his fruitful many year's work on the establishment and promotion of the health care in Sombor and broader territory. As the main county phsician he initiated the foundation and construction of the hospital in Sombor, because of high mortality rate among children, and spreading of contagious diseases like tuberculosis and trachoma. The construction of the hospital was completed in 1925 and Dr. Petrović was appointed its first director and this duty he performed for many years till the World War 2 in 1941. Under his management the hospital in Sombor became one of the best quality hospitals in the country and gave a big contribution to the promotion of health of the inhabitants of Voivodina. In spite of his extensive duties in the hospital. Dr. Milenko Petrović was very much engaged in social work, as the president of library "Laza Kosti ć". in the Soko association, Fire brigade, Rotary club, and he

  2. Dr. Arvid Lindau and discovery of von Hippel-Lindau disease.

    PubMed

    Huntoon, Kristin; Oldfield, Edward H; Lonser, Russell R

    2015-10-01

    Arvid Lindau, MD, PhD, consolidated the disparate array of benign and malignant visceral and nervous system lesions into the neoplastic syndrome known as von Hippel-Lindau (VHL) disease. Based on this pioneering work, Dr. Lindau was awarded both a Rockefeller fellowship to work in Dr. Harvey Cushing's laboratory in Boston, Massachusetts, and the Lennmalm Prize. While working in Dr. Cushing's laboratory, Dr. Lindau continued his study of CNS hemangioblastomas. His work with Dr. Cushing led to their lifelong friendship and scientific collaboration. In this paper the authors describe Arvid Lindau's pioneering work in nervous system tumor pathology, his relationship to Dr. Cushing, and his role in advancing neurological surgery and research in Europe. PMID:25748307

  3. Association of HLA-Bw46DR9 combination with juvenile myasthenia gravis in Chinese.

    PubMed Central

    Chen, W H; Chiu, H C; Hseih, R P

    1993-01-01

    One hundred and fifty two Chinese patients with myasthenia gravis in Taiwan were investigated for HLA-A, B, C and DR/DQ typing. HLA-Bw46 and DR9 frequencies were significantly increased in patients compared with the control group, and there was a decrease in DR3. Further analysis between different subgroups of patients showed Bw46 and DR9 were more significantly increased in the juvenile group than in the adult group. No single HLA allele was associated with either clinical type or thymic pathology, but there was an excess of BW46DR9 combination in both juvenile and ocular type patients. The Chinese population with myasthenia gravis is characterised by earlier age at onset, more ocular forms and less clinically severe illness than in whites, and these characteristics indicate a special subgroup that correlates with the strong Bw46DR9 association. PMID:8482958

  4. Replacement of the DR alpha chain with the E alpha chain enhances presentation of Mycoplasma arthritidis superantigen by the human class II DR molecule.

    PubMed Central

    Sawada, T; Pergolizzi, R; Ito, K; Silver, J; Atkin, C; Cole, B C; Chang, M D

    1995-01-01

    Mycoplasma arthritidis mitogen (MAM) is produced by an organism which can cause chronic proliferative arthritis in rodents. MAM possesses a typical superantigenic activity; it has the ability to activate a large panel of T cells which express specific V beta segments of the T-cell receptor. The presentation of MAM to T cells by antigen-presenting cells is mediated primarily through its binding to the major histocompatibility complex (MHC) class II E alpha chain in mice and the DR alpha chain in humans. However, MAM is much less active for human peripheral blood lymphocytes than for mouse splenocytes. It was suggested that a difference in MAM binding affinity between human and mouse class II molecules may account for their different MAM activities. To examine this possibility, we generated a panel of B-cell transfectants whose DR molecule is composed of either the DR alpha or the E alpha chain paired with a DR3 beta chain. The ability of these transfectants to present MAM to human peripheral T cells was analyzed. Our data show that transfectants expressing E alpha DR beta chimeric molecules have higher MAM-presenting activity than transfectants expressing wild-type DR alpha DR beta molecules, while the latter have higher activity in stimulating DR3-alloreactive T cells. Since both types of transfectants present MAM to T cells expressing the same T-cell receptor V beta gene families, the higher MAM-presenting activity of the E alpha transfectant is not due to its ability to interact with a different set of T cells. Furthermore, both the E alpha 1 and E alpha 2 domains contribute to this increased affinity for MAM binding. Taken together, our data suggest that there may be multiple MAM binding sites on the E alpha and DR alpha chains and residues unique to the E alpha chain may provide additional affinity for MAM. PMID:7642264

  5. [Prevention of hepatitis B--HLA DR/DQ in HBs Ag nonresponder].

    PubMed

    Ouchi, E; Hoshino, A; Miura, T; Nagahara, N; Kudo, Y; Tamura, M

    1989-11-01

    To evaluate the immunological background in HBs Ag nonresponders against hepatitis B vaccine, the lymphocyte surface marker and HLA-DR/DQ antigen were determined on hospital personnel, 70 males and 256 females, injected hepatitis B vaccine for three times. The vaccine made from the plasma of HBs Ag carriers was injected at the first and second vaccination and recombinant hepatitis B vaccine was injected at the third vaccination. A month after the third vaccination, blood was withdrawn for HBs antigen test by RIA. Border line cases (cut off index 1.0-1.9) are included in nonresponder (cut off index less than 0.9). Both nonresponders and low responders (cut off index 2-49) are more often seen in males than females and high responder (cut off index 50 or more) are seen more often in young females than males. Lymphocyte surface markers were studied by flow cytometry using the following monoclonal antibodies; OKT 3, 4, 8, DR, NK, Ia 1 and B7. No differences between lymphocyte surface markers of nonresponders and responders were noted. HLA-DR/DQ antigens were studied by the cytotoxicity test using Locus DR/DQ, Terasaki Second DR W-60 Tray and using following antibodies; DR 1, DR 2, DRW 15, DR 4, DR 5, DR 7, DR 9, DRW 10, DRW 8, DRW 12, DRW 13, DRW 6, DRW 52, DRW 53, DQW 1, DQW 6, DQW 2, DQW 3, DQW 7 and DQW 4. No significant differences between HLA-DR/DQ of nonresponders and responders were noted. PMID:2601078

  6. The UV-bright Quasar Survey (UVQS): DR1

    NASA Astrophysics Data System (ADS)

    Monroe, TalaWanda R.; Prochaska, J. Xavier; Tejos, Nicolas; Worseck, Gabor; Hennawi, Joseph F.; Schmidt, Tobias; Tumlinson, Jason; Shen, Yue

    2016-07-01

    We present the first data release (DR1) from our UV-bright Quasar Survey for new z ˜ 1 active galactic nuclei (AGNs) across the sky. Using simple GALEX UV and WISE near-IR color selection criteria, we generated a list of 1450 primary candidates with FUV < 18.5 mag. We obtained discovery spectra, primarily on 3 m-class telescopes, for 1040 of these candidates and confirmed 86% as AGNs, with redshifts generally at z > 0.5. Including a small set of observed secondary candidates, we report the discovery of 217 AGNs with FUV < 18 mag that previously had no reported spectroscopic redshift. These are excellent potential targets for UV spectroscopy before the end of the Hubble Space Telescope mission. The main data products are publicly available through the Mikulski Archive for Space Telescopes.

  7. Dr. Richard Grugel examines an ampoule of a succinonitrile mixture

    NASA Technical Reports Server (NTRS)

    2003-01-01

    On Earth when scientists melt metals, bubbles that form in the molten material can rise to the surface, pop and disappear. In microgravity -- the near-weightless environment created as the International Space Station orbits Earth -- the lighter bubbles do not rise and disappear. Prior space experiments have shown that bubbles often become trapped in the final metal or crystal sample -similar to the bubbles trapped in this sample. In the solid, these bubbles, or porosity, are defects that diminish both the material's strength and usefulness. The Pore Formation and Mobility Investigation will melt samples of a transparent modeling material, succinonitrile and succinonitrile water mixtures, shown here in an ampoule being examined by Dr. Richard Grugel, the principal investigator for the experiment at NASA's Marshall Space Flight Center in Huntsville, Ala. As the samples are processed in space, Grugel will be able to observe how bubbles form in the samples and study their movements and interactions.

  8. The Chymistry of "The Learned Dr Plot" (1640-96).

    PubMed

    Roos, Anna Marie

    2014-01-01

    In the seventeenth century, there were developing norms of openness in the presentation of scientific knowledge that were at odds with traditions of secrecy among chymists, particularly practitioners of chrysopoeia, or the transmutation of metals. This chapter analyzes how Dr. Robert Plot, the first professor of chymistry at Oxford, negotiated these boundaries within an institutional context. I first delineate his chymical and experimental practice, which incorporated procedures from medieval alchemical sources, particularly the Lullian corpus, as well as more novel practices from seventeenth-century chymistry. Then, I analyze how personal and institutional ambitions and economic considerations shaped to what extent Plot negotiated the boundaries between secrecy and the public dissemination of chymical knowledge. PMID:26103749

  9. [Interculturality in the medical practice of Dr. Albert Schweitzer].

    PubMed

    Campos-Navarro, Roberto; Ruiz-Llanos, Adriana

    2004-01-01

    Albert Schweitzer (1875-1965) was a young and promising German who at age 29 decided to undertake the profession of Medical Doctor at the University of Strassburg after finishing a career in musical studies in Paris (1899) and obtaining in Berlin a doctoral degree in Philosophy and Theology. Surprisingly, Albert Schweitzer, despite his comfortable life in Europe, decided in 1913 to practice his medical career in a remote and small Equatorial African country. He devoted nearly 50 years of his life caring for the Black population at Lamaberene, where he built a hospital. In this paper, we attempt to develop some theoretical aspects related with interculturality in the medical practice of Dr. Albert Schweitzer. We begin by considering certain sociocultural variables in hospitals that give care to patients with cultural characteristics that are substantially different from those of the health care personnel who organize, administer, and execute medical functions.

  10. GPS/DR Error Estimation for Autonomous Vehicle Localization.

    PubMed

    Lee, Byung-Hyun; Song, Jong-Hwa; Im, Jun-Hyuck; Im, Sung-Hyuck; Heo, Moon-Beom; Jee, Gyu-In

    2015-08-21

    Autonomous vehicles require highly reliable navigation capabilities. For example, a lane-following method cannot be applied in an intersection without lanes, and since typical lane detection is performed using a straight-line model, errors can occur when the lateral distance is estimated in curved sections due to a model mismatch. Therefore, this paper proposes a localization method that uses GPS/DR error estimation based on a lane detection method with curved lane models, stop line detection, and curve matching in order to improve the performance during waypoint following procedures. The advantage of using the proposed method is that position information can be provided for autonomous driving through intersections, in sections with sharp curves, and in curved sections following a straight section. The proposed method was applied in autonomous vehicles at an experimental site to evaluate its performance, and the results indicate that the positioning achieved accuracy at the sub-meter level.

  11. In Memoriam: Prof. Dr Dragutin Djurovic (1937-2013)

    NASA Astrophysics Data System (ADS)

    2013-12-01

    Prof. dr Dragutin Djurovic was born in Guca, Serbia, on December 20, 1937. He completed his primary and secondary education in Guca and Cacak. In the period 1956-1958, he studied at the General Military Academy in Belgrade. He enrolled at the Faculty of Sciences and Mathematics - Astronomy Group in 1958 and graduated in 1963. After graduation he went to study visits to Paris (1966) and Bruxelles (1972 and 1975). He obtained his MSc degree in 1970 from the University of Belgrade with a thesis entitled "Application of different types of telescopes for astronomical determination of time". His supervisor for the master thesis was Prof. Zaharije Brkic. Dragutin Djurovic defended his PhD thesis "Contribution to determination of Earth-rotation variations and polar motion" at the University of Belgrade in 1974. Most of the thesis-related research was done in Bruxelles during 1972 under the supervision of Prof. Paul Melchior.

  12. GPS/DR Error Estimation for Autonomous Vehicle Localization

    PubMed Central

    Lee, Byung-Hyun; Song, Jong-Hwa; Im, Jun-Hyuck; Im, Sung-Hyuck; Heo, Moon-Beom; Jee, Gyu-In

    2015-01-01

    Autonomous vehicles require highly reliable navigation capabilities. For example, a lane-following method cannot be applied in an intersection without lanes, and since typical lane detection is performed using a straight-line model, errors can occur when the lateral distance is estimated in curved sections due to a model mismatch. Therefore, this paper proposes a localization method that uses GPS/DR error estimation based on a lane detection method with curved lane models, stop line detection, and curve matching in order to improve the performance during waypoint following procedures. The advantage of using the proposed method is that position information can be provided for autonomous driving through intersections, in sections with sharp curves, and in curved sections following a straight section. The proposed method was applied in autonomous vehicles at an experimental site to evaluate its performance, and the results indicate that the positioning achieved accuracy at the sub-meter level. PMID:26307997

  13. [Interculturality in the medical practice of Dr. Albert Schweitzer].

    PubMed

    Campos-Navarro, Roberto; Ruiz-Llanos, Adriana

    2004-01-01

    Albert Schweitzer (1875-1965) was a young and promising German who at age 29 decided to undertake the profession of Medical Doctor at the University of Strassburg after finishing a career in musical studies in Paris (1899) and obtaining in Berlin a doctoral degree in Philosophy and Theology. Surprisingly, Albert Schweitzer, despite his comfortable life in Europe, decided in 1913 to practice his medical career in a remote and small Equatorial African country. He devoted nearly 50 years of his life caring for the Black population at Lamaberene, where he built a hospital. In this paper, we attempt to develop some theoretical aspects related with interculturality in the medical practice of Dr. Albert Schweitzer. We begin by considering certain sociocultural variables in hospitals that give care to patients with cultural characteristics that are substantially different from those of the health care personnel who organize, administer, and execute medical functions. PMID:15633574

  14. GPS/DR Error Estimation for Autonomous Vehicle Localization.

    PubMed

    Lee, Byung-Hyun; Song, Jong-Hwa; Im, Jun-Hyuck; Im, Sung-Hyuck; Heo, Moon-Beom; Jee, Gyu-In

    2015-01-01

    Autonomous vehicles require highly reliable navigation capabilities. For example, a lane-following method cannot be applied in an intersection without lanes, and since typical lane detection is performed using a straight-line model, errors can occur when the lateral distance is estimated in curved sections due to a model mismatch. Therefore, this paper proposes a localization method that uses GPS/DR error estimation based on a lane detection method with curved lane models, stop line detection, and curve matching in order to improve the performance during waypoint following procedures. The advantage of using the proposed method is that position information can be provided for autonomous driving through intersections, in sections with sharp curves, and in curved sections following a straight section. The proposed method was applied in autonomous vehicles at an experimental site to evaluate its performance, and the results indicate that the positioning achieved accuracy at the sub-meter level. PMID:26307997

  15. Dr. Cheryl Nickerson studies Salmonella in simulated low-g

    NASA Technical Reports Server (NTRS)

    2003-01-01

    Dr. Cheryl Nickerson of Tulane University is studying the effects of simulated low-g on a well-known pathogen, Salmonella typhimurium, a bacterium that causes two to four million cases of gastrointestinal illness in the United States each year. While most healthy people recover readily, S. typhimurium can kill people with weakened immune systems. Thus, a simple case of food poisoning could disrupt a space mission. Using the NASA rotating-wall bioreactor, Nickerson cultured S. typhimurium in modeled microgravity. Mice infected with the bacterium died an average of three days faster than the control mice, indicating that S. typhimurium's virulence was enhanced by the bioreactor. Earlier research showed that 3 percent of the genes were altered by exposure to the bioreactor. Nickerson's work earned her a 2001 Presidential Early Career Award for Scientists and Engineers.

  16. Dr. Cheryl Nickerson studying Salmonella at Tulane University

    NASA Technical Reports Server (NTRS)

    2003-01-01

    Dr. Cheryl Nickerson (right) of Tulane University is studying the effects of simulated low-g on a well-known pathogen, Salmonella typhimurium, a bacterium that causes two to four million cases of gastrointestinal illness in the United States each year. While most healthy people recover readily, S. typhimurium can kill people with weakened immune systems. Thus, a simple case of food poisoning could disrupt a space mission. Using the NASA rotating-wall bioreactor, Nickerson cultured S. typhimurium in modeled microgravity. Mice infected with the bacterium died an average of three days faster than the control mice, indicating that S. typhimurium's virulence was enhanced by the bioreactor. Earlier research showed that 3 percent of the genes were altered by exposure to the bioreactor. Nickerson's work earned her a 2001 Presidential Early Career Award for Scientists and Engineers.

  17. The Investigation of SBS Galaxies from SDSS DR 7

    NASA Astrophysics Data System (ADS)

    Gyulzadyan, M. V.; Mickaelian, A. M.; Abrahamyan, H. V.; Paronyan, G. M.

    2016-09-01

    The Second Byurakan Survey (SBS) is a well-known combined survey, which uses the presence of UV-excess radiation in the continuum, or the presence of emission lines in the spectra for the identification of active and star-forming galaxies. This work reports on a comparative study of galaxies identified with UV-excess (UVX), and galaxies identified via emission-line techniques (ELG) in the fields of the SBS. The spectroscopic parameters used for the comparison are the [OII]λ3727Å/Hβ and [OIII]λ5007Å/Hβ emission-line ratios, the equivalent widths of [OII]λ3727Å, [OIII]λ5007Å, and Hβ emission lines. Spectroscopic parameters were determined from the spectra obtained from SDSS DR7. Based on emission line ratios, we have built also diagnostic diagrams to distinguish AGN (Seyferts and LINERs) and SB galaxies.

  18. Catalytic antibodies: balancing between Dr. Jekyll and Mr. Hyde.

    PubMed

    Belogurov, Alexey; Kozyr, Arina; Ponomarenko, Natalia; Gabibov, Alexander

    2009-11-01

    The immunoglobulin molecule is a perfect template for the de novo generation of biocatalytic functions. Catalytic antibodies, or abzymes, obtained by the structural mimicking of enzyme active sites have been shown to catalyze numerous chemical reactions. Natural enzyme analogs for some of these reactions have not yet been found or possibly do not exist at all. Nowadays, the dramatic breakthrough in antibody engineering and expression technologies has promoted a considerable expansion of immunoglobulin's medical applications and is offering abzymes a unique chance to become a promising source of high-precision "catalytic vaccines." At the same time, the discovery of natural abzymes on the background of autoimmune disease revealed their beneficial and pathogenic roles in the disease progression. Thus, the conflicting Dr. Jekyll and Mr. Hyde protective and destructive essences of catalytic antibodies should be carefully considered in the development of therapeutic abzyme applications. PMID:19795406

  19. User's Manual for FEMOM3DR. Version 1.0

    NASA Technical Reports Server (NTRS)

    Reddy, C. J.

    1998-01-01

    FEMoM3DR is a computer code written in FORTRAN 77 to compute radiation characteristics of antennas on 3D body using combined Finite Element Method (FEM)/Method of Moments (MoM) technique. The code is written to handle different feeding structures like coaxial line, rectangular waveguide, and circular waveguide. This code uses the tetrahedral elements, with vector edge basis functions for FEM and triangular elements with roof-top basis functions for MoM. By virtue of FEM, this code can handle any arbitrary shaped three dimensional bodies with inhomogeneous lossy materials; and due to MoM the computational domain can be terminated in any arbitrary shape. The User's Manual is written to make the user acquainted with the operation of the code. The user is assumed to be familiar with the FORTRAN 77 language and the operating environment of the computers on which the code is intended to run.

  20. The Chymistry of "The Learned Dr Plot" (1640-96).

    PubMed

    Roos, Anna Marie

    2014-01-01

    In the seventeenth century, there were developing norms of openness in the presentation of scientific knowledge that were at odds with traditions of secrecy among chymists, particularly practitioners of chrysopoeia, or the transmutation of metals. This chapter analyzes how Dr. Robert Plot, the first professor of chymistry at Oxford, negotiated these boundaries within an institutional context. I first delineate his chymical and experimental practice, which incorporated procedures from medieval alchemical sources, particularly the Lullian corpus, as well as more novel practices from seventeenth-century chymistry. Then, I analyze how personal and institutional ambitions and economic considerations shaped to what extent Plot negotiated the boundaries between secrecy and the public dissemination of chymical knowledge.

  1. Dr. Arthur Conan Doyle and the case of congenital syphilis.

    PubMed

    Silverstein, Arthur M; Ruggere, Christine

    2006-01-01

    In 1894, Dr. Arthur Conan Doyle wrote "The Third Generation," a short story involving the transmission of congenital syphilis from generation to generation. Analysts of his writings have interpreted the pathogenetic mechanism involved in modern terms: infection of mother by father and then transplacental infection of the fetus. However, a review of the contemporary literature and the history of the concepts of congenital and "hereditary" syphilis demonstrates that the late 19th-century understanding of the process involved a Lamarckian transmission of paternal infection, via the sperm at the moment of conception. It was undoubtedly this concept that Doyle learned in medical school in the late 1870s and that provided the background to his story.

  2. Biography: Dr Iain Frame, director of research, prostate cancer UK.

    PubMed

    Frame, Iain; Maprayil, Sophia

    2014-11-01

    Sophia Maprayil, Commissioning Editor for Expert Review of Anticancer Therapy, talks to Dr Iain Frame, Director of Research for Prostate Cancer UK. Iain is Prostate Cancer UK's first Director of Research, responsible for overseeing the development and implementation of the charity's ambitious new research strategy. He joined Prostate Cancer UK in 2012 from Diabetes UK where he held the post of Research Director for 5 years. Since joining Prostate Cancer UK in 2012 Iain has overseen a dramatic increase in the charity's research spend, from 2 million a year, to 7.5 million a year. Previously Iain worked in research management at the Wellcome Trust and before that as a parasitologist and researcher exploring various aspects of molecular biology of a number of different parasites.

  3. Characteristics of dr1790 disruptant and its functional analysis in Deinococcus radiodurans.

    PubMed

    Cheng, Jianhui; Wang, Hu; Xu, Xin; Wang, Liangyan; Tian, Bing; Hua, Yuejin

    2015-06-01

    Deinococcus radiodurans (DR) is an extremophile that is well known for its resistance to radiation, oxidants and desiccation. The gene dr1790 of D. radiodurans was predicted to encode a yellow-related protein. The primary objective of the present study was to characterize the biological function of the DR1790 protein, which is a member of the ancient yellow/major royal jelly (MRJ) protein family, in prokaryotes. Fluorescence labeling demonstrated that the yellow-related protein encoded by dr1790 is a membrane protein. The deletion of the dr1790 gene decreased the cell growth rate and sensitivity to hydrogen peroxide and radiation and increased the membrane permeability of D. radiodurans. Transcript profiling by microarray and RT-PCR analyses of the dr1790 deletion mutant suggested that some genes that are involved in protein secretion and transport were strongly suppressed, while other genes that are involved in protein quality control, such as chaperones and proteases, were induced. In addition, the expression of genes with predicted functions that are involved in antioxidant systems, electron transport, and energy metabolism was significantly altered through the disruption of dr1790. Moreover, the results of proteomic analyses using 2-DE and MS also demonstrated that DR1790 contributed to D. radiodurans survival. Taken together, these results indicate that the DR1790 protein from the ancient yellow protein family plays a pleiotropic role in the survival of prokaryotic cells and contributes to the extraordinary resistance of D. radiodurans against oxidative and radiation stresses. PMID:26273280

  4. HLA-A, -B and -DR allele and haplotype frequencies in Malays.

    PubMed

    Dhaliwal, J S; Shahnaz, M; Too, C L; Azrena, A; Maiselamah, L; Lee, Y Y; Irda, Y A; Salawati, M

    2007-03-01

    One thousand four hundreds and forty-five Malays registered with the Malaysian Marrow Donor Registry were typed for HLA-A, HLA-B and HLA-DR. Fifteen HLA-A, twenty nine HLA-B and fourteen HLA-DR alleles were detected. The most common HLA-A alleles and their frequencies were HLA-A24 (0.35), HLA-A11 (0.21) and HLA-A2 (0.15). The most common HLA-B alleles were HLA-B15 (0.26), HLA-B35 (0.11) and HLA-B18 (0.10) while the most common HLA-DR alleles were HLA-DR15 (0.28), HLA-DR12 (0.27) and HLA-DR7 (0.10). A24-B15-DR12 (0.047), A24-B15-DR15 (0.03) and the A24-B35-DR12 (0.03) were the most frequent haplotypes. This data may be useful in determining the probability of finding a matched donor and for estimating the incidence of HLA associated diseases.

  5. Safety evaluation for packaging for 1720-DR sodium-filled tank

    SciTech Connect

    Mercado, M.S.

    1996-03-09

    Preparations are under way to sell the sodium stored in the 1720-DR tank in the 1720-DR building. This will require that the tank, as well as the 1720-DR facility, be moved to the 300 Area, so that the sodium may be melted and transferred into a railroad tanker car. Because the sodium is a hazardous material and is being shipped in a nonspecification packaging, a safety evaluation for packaging (SEP) is required. This SEP approves the sodium-filled tank for a single shipment from the 105-DR area to the 300 Area.

  6. Characteristics of dr1790 disruptant and its functional analysis in Deinococcus radiodurans

    PubMed Central

    Cheng, Jianhui; Wang, Hu; Xu, Xin; Wang, Liangyan; Tian, Bing; Hua, Yuejin

    2015-01-01

    Deinococcus radiodurans (DR) is an extremophile that is well known for its resistance to radiation, oxidants and desiccation. The gene dr1790 of D. radiodurans was predicted to encode a yellow-related protein. The primary objective of the present study was to characterize the biological function of the DR1790 protein, which is a member of the ancient yellow/major royal jelly (MRJ) protein family, in prokaryotes. Fluorescence labeling demonstrated that the yellow-related protein encoded by dr1790 is a membrane protein. The deletion of the dr1790 gene decreased the cell growth rate and sensitivity to hydrogen peroxide and radiation and increased the membrane permeability of D. radiodurans. Transcript profiling by microarray and RT-PCR analyses of the dr1790 deletion mutant suggested that some genes that are involved in protein secretion and transport were strongly suppressed, while other genes that are involved in protein quality control, such as chaperones and proteases, were induced. In addition, the expression of genes with predicted functions that are involved in antioxidant systems, electron transport, and energy metabolism was significantly altered through the disruption of dr1790. Moreover, the results of proteomic analyses using 2-DE and MS also demonstrated that DR1790 contributed to D. radiodurans survival. Taken together, these results indicate that the DR1790 protein from the ancient yellow protein family plays a pleiotropic role in the survival of prokaryotic cells and contributes to the extraordinary resistance of D. radiodurans against oxidative and radiation stresses. PMID:26273280

  7. Characteristics of dr1790 disruptant and its functional analysis in Deinococcus radiodurans.

    PubMed

    Cheng, Jianhui; Wang, Hu; Xu, Xin; Wang, Liangyan; Tian, Bing; Hua, Yuejin

    2015-06-01

    Deinococcus radiodurans (DR) is an extremophile that is well known for its resistance to radiation, oxidants and desiccation. The gene dr1790 of D. radiodurans was predicted to encode a yellow-related protein. The primary objective of the present study was to characterize the biological function of the DR1790 protein, which is a member of the ancient yellow/major royal jelly (MRJ) protein family, in prokaryotes. Fluorescence labeling demonstrated that the yellow-related protein encoded by dr1790 is a membrane protein. The deletion of the dr1790 gene decreased the cell growth rate and sensitivity to hydrogen peroxide and radiation and increased the membrane permeability of D. radiodurans. Transcript profiling by microarray and RT-PCR analyses of the dr1790 deletion mutant suggested that some genes that are involved in protein secretion and transport were strongly suppressed, while other genes that are involved in protein quality control, such as chaperones and proteases, were induced. In addition, the expression of genes with predicted functions that are involved in antioxidant systems, electron transport, and energy metabolism was significantly altered through the disruption of dr1790. Moreover, the results of proteomic analyses using 2-DE and MS also demonstrated that DR1790 contributed to D. radiodurans survival. Taken together, these results indicate that the DR1790 protein from the ancient yellow protein family plays a pleiotropic role in the survival of prokaryotic cells and contributes to the extraordinary resistance of D. radiodurans against oxidative and radiation stresses.

  8. Expression and mutational analysis of DinB-like protein DR0053 in Deinococcus radiodurans.

    PubMed

    Appukuttan, Deepti; Seo, Ho Seong; Jeong, Sunwook; Im, Sunghun; Joe, Minho; Song, Dusup; Choi, Jungjoon; Lim, Sangyong

    2015-01-01

    In order to understand the mechanism governing radiation resistance in Deinococcus radiodurans, current efforts are aimed at identifying potential candidates from a large repertoire of unique Deinococcal genes and protein families. DR0053 belongs to the DinB/YfiT protein family, which is an over-represented protein family in D. radiodurans. We observed that dr0053 transcript levels were highly induced in response to gamma radiation (γ-radiation) and mitomycin C (MMC) exposure depending on PprI, RecA and the DrtR/S two-component signal transduction system. Protein profiles demonstrated that DR0053 is a highly induced protein in cultures exposed to 10 kGy γ-radiation. We were able to determine the transcriptional start site of dr0053, which was induced upon irradiation, and to assign the 133-bp promoter region of dr0053 as essential for radiation responsiveness through primer extension and promoter deletion analyses. A dr0053 mutant strain displayed sensitivity to γ-radiation and MMC exposure, but not hydrogen peroxide, suggesting that DR0053 helps cells recover from DNA damage. Bioinformatic analyses revealed that DR0053 is similar to the Bacillus subtilis protein YjoA, which is a substrate of bacterial protein-tyrosine kinases. Taken together, the DNA damage-inducible (din) gene dr0053 may be regulated at the transcriptional and post-translational levels.

  9. Weak association between HLA-DR4 and rheumatoid arthritis in Chilean patients.

    PubMed Central

    Massardo, L; Jacobelli, S; Rodríguez, L; Rivero, S; González, A; Marchetti, R

    1990-01-01

    Evidence has suggested a genetic link between the HLA-DR4 phenotype and rheumatoid arthritis (RA), particularly in its seropositive form. Such an association varies among different ethnic groups and remains controversial for seronegative patients. Data obtained for a group of 64 Chilean patients with RA (46 seropositive, 18 seronegative), as defined by the 1987 criteria of the American Rheumatism Association, and for 76 controls are reported here. The prevalence of HLA-DR4 and DR9 was significantly increased in the group of patients considered as a whole. The prevalence of HLA-DR4 was not significantly higher, however, when seronegative and seropositive patients were separately compared with controls. Also, it did not correlate with the severity of the disease within each subgroup of patients. On the other hand, HLA-DR9 showed a highly significant difference, not previously described, only for the seropositive patients in comparison with controls. The prevalence of DQ specificities showed no relevant differences among the groups. The HLA-DR4 serotype, therefore, is a weak marker for RA and does not differentiate any subgroup of patients in the Chilean group studied. This new finding, indicating an association between RA and the DR9 antigen, may be explained by the suggestion that susceptibility epitopes are shared among different DR molecules. This hypothesis might also account for the variation in the association of DR4 with RA. PMID:2344208

  10. Expression and Mutational Analysis of DinB-Like Protein DR0053 in Deinococcus radiodurans

    PubMed Central

    Appukuttan, Deepti; Seo, Ho Seong; Jeong, Sunwook; Im, Sunghun; Joe, Minho; Song, Dusup; Choi, Jungjoon; Lim, Sangyong

    2015-01-01

    In order to understand the mechanism governing radiation resistance in Deinococcus radiodurans, current efforts are aimed at identifying potential candidates from a large repertoire of unique Deinococcal genes and protein families. DR0053 belongs to the DinB/YfiT protein family, which is an over-represented protein family in D. radiodurans. We observed that dr0053 transcript levels were highly induced in response to gamma radiation (γ-radiation) and mitomycin C (MMC) exposure depending on PprI, RecA and the DrtR/S two-component signal transduction system. Protein profiles demonstrated that DR0053 is a highly induced protein in cultures exposed to 10 kGy γ-radiation. We were able to determine the transcriptional start site of dr0053, which was induced upon irradiation, and to assign the 133-bp promoter region of dr0053 as essential for radiation responsiveness through primer extension and promoter deletion analyses. A dr0053 mutant strain displayed sensitivity to γ-radiation and MMC exposure, but not hydrogen peroxide, suggesting that DR0053 helps cells recover from DNA damage. Bioinformatic analyses revealed that DR0053 is similar to the Bacillus subtilis protein YjoA, which is a substrate of bacterial protein-tyrosine kinases. Taken together, the DNA damage-inducible (din) gene dr0053 may be regulated at the transcriptional and post-translational levels. PMID:25706748

  11. GENESI-DR Portal: a scientific gateway to distributed repositories

    NASA Astrophysics Data System (ADS)

    Goncalves, Pedro; Brito, Fabrice; D'Andria, Fabio; Cossu, Roberto; Fusco, Luigi

    2010-05-01

    GENESI-DR (Ground European Network for Earth Science Interoperations - Digital Repositories) is a European Commission (EC)-funded project, kicked-off early 2008 lead by ESA; partners include Space Agencies (DLR, ASI, CNES), both space and no-space data providers such as ENEA (I), Infoterra (UK), K-SAT (N), NILU (N), JRC (EU) and industry as Elsag Datamat (I), CS (F) and TERRADUE (I). GENESI-DR intends to meet the challenge of facilitating "time to science" from different Earth Science disciplines in discovery, access and use (combining, integrating, processing, …) of historical and recent Earth-related data from space, airborne and in-situ sensors, which are archived in large distributed repositories. "Discovering" which data are available on a "geospatial web" is one of the main challenges ES scientists have to face today. Some well- known data sets are referred to in many places, available from many sources. For core information with a common purpose many copies are distributed, e.g., VMap0, Landsat, and SRTM. Other data sets in low or local demand may only be found in a few places and niche communities. Relevant services, results of analysis, applications and tools are accessible in a very scattered and uncoordinated way, often through individual initiatives from Earth Observation mission operators, scientific institutes dealing with ground measurements, service companies or data catalogues. In the discourse of Spatial Data Infrastructures, there are "catalogue services" - directories containing information on where spatial data and services can be found. For metadata "records" describing spatial data and services, there are "registries". The Geospatial industry coins specifications for search interfaces, where it might do better to reach out to other information retrieval and Internet communities. These considerations are the basis for the GENESI-DR scientific portal, which adopts a simple model allowing the geo-spatial classification and discovery of

  12. Pioneers of Study on Desorption Induced by Electronic Transitions; Achievements by Dr. Yoshioki Ishikawa and Dr. Yoshio Ohta

    NASA Astrophysics Data System (ADS)

    Mase, Kazuhiko; Nambu, Akira

    Dr. Yoshioki Ishikawa is a pioneer who carried out systematic electron stimulated desorption (ESD) investigations for hydrogen adsorbed on a clean platinum plate (H2/Pt) under ultrahigh vacuum (UHV) conditions in 1942. (His name is spelled as Yosioki Isikawa in the original papers.) Although his papers are referred in several papers on desorption induced by electronic transitions (DIET), these seem to be not as well-known as famous ones by Menzel, Gomer, and Redhead in 1964. We describe his pioneering work in this article. He developed an UHV apparatus made of glass with a Pt plate and an oxide cathode pumped by a small mercury pump via a liquid air trap. Clear ESD signals were observed for H2/Pt at excitation energies of 8, 12, 14, 33-46, and 46-51 eV. He assigned the desorbate to atomic hydrogen (H), because it was pumped by a glass wall baked above 350°C. Based on these results and the potential curves of H2 in the gas phase, he proposed a model for the ESD of H from H2/Pt that is, the first step is an electronic transition of adsorbed H2, and the second is the desorption of H along the repulsive potential surface of the excited state. This was the first introduction of the notion of DIET. He also carried out an ESD study of H2O/Pt in 1943. We also introduce achievements by Dr. Yoshio Ohta, who was another pioneer in the field of DIET. He measured electron-stimulated ion desorption from an oxidized Ni plate. He found that the threshold excitation energy for ion desorption is 22 eV, and that the kinetic energy of the desorbed ion is 1˜2 eV. To explain these results, he also proposed the concept of DIET.

  13. A supertypic HLA class II determinant shared by DR1 and DRw9, and crossreactive with DR2, defined by human monoclonal antibody.

    PubMed

    Kosinski, S; Yang, S Y; Pistillo, M P; Hämmerling, U

    1988-03-01

    A human monoclonal antibody Pez.2F5, produced by a lymphoblastoid cell line, has been established in vitro by Epstein-Barr virus (EBV) transformation of B lymphocytes isolated from the blood of a volunteer immunized with allogeneic peripheral blood leukocytes (PBLs). The antibody reacted with a new supertypic determinant expressed on all lymphoblastoid cell lines homozygous for HLA-DR1, -2, and -w9. The genetic linkage of the Pez.2F5 determinant to the HLA region was demonstrated by family segregation studies. Quantitative absorption studies indicated that DR2-positive cells required more Pez.2F5 antibody for lysis, and since their absorption capacity was significantly lower than that of DR1- or DRw9-positive cells, it is likely that the Pez.2F5 determinant of the DR2 haplotype is crossreactive but not identical with the determinant found on the latter haplotypes. In addition, on a test panel of HLA-typed B lymphocytes, Pez.2F5 showed perfect correlation with DR1 and DRw9, but reacted with only a fraction of DR2-positive cells. The Pez.2F5 determinant was found to be absent from resting T lymphocytes, but its expression could be identified on IL-2-dependent T-cell lines by cytotoxicity and flow cytofluorometric analysis. By sequential immunoprecipitation and SDS gel analysis of antigens of DR1 cells it was determined that the Pez.2F5 determinant is carried by HLA class II DR molecules. Thus, the Pez.2F5 is the first described human monoclonal antibody able to immunoprecipitate HLA class II-related molecules. PMID:2453492

  14. Star Formation in the DR21 Region (A)

    NASA Technical Reports Server (NTRS)

    2004-01-01

    [figure removed for brevity, see original site] Annotated mosaic

    Hidden behind a shroud of dust in the constellation Cygnus is a stellar nursery called DR21, which is giving birth to some of the most massive stars in our galaxy. Visible light images reveal no trace of this interstellar cauldron because of heavy dust obscuration. In fact, visible light is attenuated in DR21 by a factor of more than 10,000,000,000,000,000,000,000,000,000,000,000,000,000 (ten thousand trillion heptillion).

    New images from NASA's Spitzer Space Telescope allow us to peek behind the cosmic veil and pinpoint one of the most massive natal stars yet seen in our Milky Way galaxy. The never-before-seen star is 100,000 times as bright as the Sun. Also revealed for the first time is a powerful outflow of hot gas emanating from this star and bursting through a giant molecular cloud.

    The colorful image (top panel) is a large-scale composite mosaic assembled from data collected at a variety of different wavelengths. Views at visible wavelengths appear blue, near-infrared light is depicted as green, and mid-infrared data from the InfraRed Array Camera (IRAC) aboard NASA's Spitzer Space Telescope is portrayed as red. The result is a contrast between structures seen in visible light (blue) and those observed in the infrared (yellow and red). A quick glance shows that most of the action in this image is revealed to the unique eyes of Spitzer. The image covers an area about two times that of a full moon.

    Each of the constituent images is shown below the large mosaic. The Digital Sky Survey (DSS) image (lower left) provides a familiar view of deep space, with stars scattered around a dark field. The reddish hue is from gas heated by foreground stars in this region. This fluorescence fades away in the near-infrared Two-Micron All-Sky Survey (2MASS) image (lower center), but other features start to appear through the obscuring clouds of dust, now increasingly transparent. Many more

  15. [WHO AFFECTS THE PATIENT, DR. GOOGLE OR THE DOCTOR?].

    PubMed

    Mishali, Moshe; Avrech, Tova

    2015-09-01

    In the last decade the World Wide Web has become one of the prime sources for medical data searches. The abundance of information and emphasis on consumer communication, which are the main characteristics of the new generation of the web named "Web 2.0", enable users to engage and educate others by sharing and collaborating knowledge. It also enables them to receive medical information based on the experience of other patients, while the duration of the traditional physician's visit has shortened. However, using Web 2.0 for health collaboration has drawbacks as well: When alternative ways of "knowing" replace objective medical facts, there is danger of misinformation and truth "flattening". This article examines the distribution of medical misinformation online: Its characteristics, the nature of the messages presented online and the means that might help protect users and patients from it. The authors hold positions in the Israeli Dairy Board (IDB): Dr. Averch manages the health field on the IDB, and the findings in this article are based on research that she is leading as part of this position, and Dr. Mishali is a trained psychologist, and acts as a strategic consultant for IDB in the field of coping with the opposition to milk and its products. In this article it is initially shown how the characteristics of information distribution in general help spreading medical misinformation online: The decline of doctors' authority as sole providers of medical information, disillusionment and suspicion towards science and the notion of expertise, and the emergence of new ways to evaluate information, based on community ties. The nature of this pseudo-medical information will then be discussed, including the range of the phenomenon and the probability of users to be affected by it. Furthermore, we will raise specific tactics in which anti-establishment messages are portrayed; examples will be given of the use of emotion evoking content in the anti-establishment messages

  16. [WHO AFFECTS THE PATIENT, DR. GOOGLE OR THE DOCTOR?].

    PubMed

    Mishali, Moshe; Avrech, Tova

    2015-09-01

    In the last decade the World Wide Web has become one of the prime sources for medical data searches. The abundance of information and emphasis on consumer communication, which are the main characteristics of the new generation of the web named "Web 2.0", enable users to engage and educate others by sharing and collaborating knowledge. It also enables them to receive medical information based on the experience of other patients, while the duration of the traditional physician's visit has shortened. However, using Web 2.0 for health collaboration has drawbacks as well: When alternative ways of "knowing" replace objective medical facts, there is danger of misinformation and truth "flattening". This article examines the distribution of medical misinformation online: Its characteristics, the nature of the messages presented online and the means that might help protect users and patients from it. The authors hold positions in the Israeli Dairy Board (IDB): Dr. Averch manages the health field on the IDB, and the findings in this article are based on research that she is leading as part of this position, and Dr. Mishali is a trained psychologist, and acts as a strategic consultant for IDB in the field of coping with the opposition to milk and its products. In this article it is initially shown how the characteristics of information distribution in general help spreading medical misinformation online: The decline of doctors' authority as sole providers of medical information, disillusionment and suspicion towards science and the notion of expertise, and the emergence of new ways to evaluate information, based on community ties. The nature of this pseudo-medical information will then be discussed, including the range of the phenomenon and the probability of users to be affected by it. Furthermore, we will raise specific tactics in which anti-establishment messages are portrayed; examples will be given of the use of emotion evoking content in the anti-establishment messages

  17. HLA-DR typing of women with recurrent late spontaneous abortion and unsuccessful cervical cerclage.

    PubMed

    Mohapeloa, H; Christiansen, O B; Grunnet, N

    1998-04-01

    The release of certain cytokines, e.g. tumour necrosis factor (TNF)-alpha, in the amniotic fluid has been suggested to be a cause of preterm birth. The predisposition to excessive liberation of cytokines from peripheral leukocytes has been shown to depend partly on the individual's HLA-DR genotype. The HLA-DR1 and -DR3 alleles have previously been reported as being associated with a TNF-alpha high responder status and have also been associated with unexplained recurrent spontaneous abortions. In the present study, HLA-DR typing was performed in 10 women who had experienced recurrent very early preterm births resulting in perinatal death, or late spontaneous abortions under a clinical picture resembling that traditionally attributed to cervical incompetence. All patients had had at least one mid-trimester miscarriage in spite of the insertion of a cervical cerclage. Nine out of 10 (90%) patients had the HLA-DR phenotypes DR1 and/or DR3 compared with 37% in the background population (P < 0.005). The results suggest that HLA-DR-associated immunological factors might play a part in recurrent late spontaneous abortions and extremely preterm births under a cervical incompetence-like picture, at least in the subset of cases not treatable by cervical cerclage.

  18. Vikrant Sahasrabuddhe, MBBS, MPH, DrPH | Division of Cancer Prevention

    Cancer.gov

    Dr. Vikrant Sahasrabuddhe received his medical degree from the University of Pune in India, his master's and doctorate degrees in public health from the University of Alabama at Birmingham, and completed fellowship training in epidemiology at the Johns Hopkins University Bloomberg School of Public Health and at the National Cancer Institute. Before joining NCI in 2015, Dr. |

  19. Dr. Bernard Langer — inductee into the Canadian Medical Hall of Fame

    PubMed Central

    Greig, Paul D.; Rotstein, Ori D.

    2015-01-01

    Summary Dr. Bernard Langer’s induction into the Canadian Medical Hall of Fame acknowledges his profound effect on medicine and surgery in Canada and an impact that has been truly international. In this brief biography, we highlight the major accomplishments that have made Dr. Langer a pre-eminent leader, innovator, teacher and exemplary surgeon. PMID:25799243

  20. Annotated Bibliography of Dr Salmani Nodoushan's Research on Education and Language Teaching

    ERIC Educational Resources Information Center

    Etemadfar Kashani, Abbas Ali

    2016-01-01

    This is an annotated bibliography of the research conducted on education and language teaching and assessment by Dr. Mohammad Ali Salmani Nodoushan in the past 25 years. This bibliography is a precise picture of the current state of education and language teaching and assessment in Iran. Dr. Salmani Nodoushan is the most distinguished Iranian…

  1. HLA-DR and -DQ gene polymorphism in Latvian patients with insulin-dependent diabetes mellitus.

    PubMed

    Shtauvere, A; Rumba, I; Dzivite, I; Sanjeevi, C B

    1998-10-01

    Latvian insulin-dependent diabetes mellitus (IDDM) patients (n=101) and healthy controls (n=111) were analyzed for HLA-DR and DQ polymorphism. DR3-DQ2 and DR4-DQ8 were positively associated and DR15-DQ6, DR13-DQ6, DR1-DQ5 and DQ7 negatively associated with the disease. The incidence of IDDM in Latvia is very low (6.5 per 100,000) compared to Sweden (24.4 per 100,000), even though Latvia is close to Sweden. The reasons for the decreased incidence are not clear. When the negatively associated DQ were taken together in the healthy controls, more than 75% of the healthy controls were positive for one of the four negatively associated DQ molecules. The excess frequency of the negatively associated DQ molecules in the general population could explain the lower incidence of IDDM in Latvia. Association of HLA-DR and DQ genes with autoantibody markers shows DR3, but not DQ2, to be increased in GAD65 antibody-positive compared to antibody-negative patients. This association was not observed with ICA512 antibodies.

  2. Reader-Response to Dr. Seuss: Middle School Students and Social Issues.

    ERIC Educational Resources Information Center

    Cobb, Susan M.

    A study investigated to what extent average middle school students were able to perceive the social issues embedded in literature by Dr. Seuss. Seventy-four seventh-grade students responded to five Dr. Seuss stories in free-writing exercises, response worksheets, and question worksheets. Results showed that the majority of students (approximately…

  3. Genomic analysis identifies class II mismatches in serologically DR-compatible human renal allografts.

    PubMed

    Bushell, A; Wood, K J; Morris, P J

    1988-11-01

    Many studies, including those from our own center, have shown that matching the donor and recipient for HLA-DR antigens has a beneficial effect on the outcome of cadaveric renal transplantation. However, cases of irreversible graft rejection are sometimes seen in patients who have received an HLA-DR-compatible kidney, suggesting that serologic compatibility for HLA-DR may not always ensure reduced alloreactivity toward the graft. We have examined a number of recipients and their serologically DR-compatible cadaveric donors by Southern blotting and hybridization with locus specific HLA class II probes in order to determine whether in these patients there were class II mismatches that had been undetected by serology. The results show that the analysis of DR beta restriction fragment patterns does little more than complement and confirm the serologic identification of HLA-DR. Hybridization with DQ alpha and DQ beta probes, however, significantly extends the number of DQ specificities that can be detected and suggests that DQ mismatches in DR-compatible donor-recipient pairs may be more common than previously supposed, although it is not possible to draw any conclusions on the influence of DQ incompatibilities in the presence of DR compatibility on graft outcome.

  4. HLA class II genes polymorphism in DR4 giant cell arteritis patients.

    PubMed

    Bignon, J D; Ferec, C; Barrier, J; Pennec, Y; Verlingue, C; Cheneau, M L; Lucas, V; Muller, J Y; Saleun, J P

    1988-11-01

    We have previously reported a significant increase of HLA-DR4 antigen frequency in giant cell arteritis (GCA). This finding suggested an important role of immunogenetic factors in this syndrome. Recent data suggest that inherited susceptibility to several autoimmune diseases was associated with specific DR4 associated DQ beta alleles. DNAs from 27 DR4 positive patients with GCA were digested with Taq I and Bam HI, analysed on 0.7% agarose gel and hybridized with DR beta, DQ alpha and DQ beta probes. DR beta hybridization produced no variant detectable within DR4. DQ beta probe confirmed two clusters among DR4 associated DQW3 alleles: DQW 3.1 (Bam HI 360 Kb) and DQw 3.2 (Taq I 1.9 Kb and Bam HI 11 Kb). Among our 27 DR4 positive patients, 34% were DQW 3.1 and 66% were DQW 3.2. These frequencies are the same as those observed in healthy controls. PMID:2906182

  5. GLI3-dependent repression of DR4 mediates hedgehog antagonism of TRAIL-induced apoptosis.

    PubMed

    Kurita, S; Mott, J L; Almada, L L; Bronk, S F; Werneburg, N W; Sun, S-Y; Roberts, L R; Fernandez-Zapico, M E; Gores, G J

    2010-08-26

    Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis through its cognate receptors death receptor 4 (DR4) and death receptor 5 (DR5), preferentially in malignant cells. However, many malignant cells remain resistant to TRAIL cytotoxicity by poorly characterized mechanisms. Here, using cholangiocarcinoma cells, as a model for TRAIL resistance, we identified a role for the oncogenic Hedgehog (Hh)-GLI pathway in the regulation of TRAIL cytotoxicity. Blockade of Hh using pharmacological and genetic tools sensitizes the cells to TRAIL cytotoxicity. Restoration of apoptosis sensitivity coincided with upregulation of DR4 expression, while expression of other death effector proteins remained unaltered. Knockdown of DR4 mimics Hh-mediated resistance to TRAIL cytotoxicity. Hh regulates the expression of DR4 by modulating the activity of its promoter. Luciferase, chromatin immunoprecipitation and expression assays show that the transcription factor GLI3 binds to the DR4 promoter and Hh requires an intact GLI3-repression activity to silence DR4 expression. Finally, small interfering RNA (siRNA)-targeted knockdown of GLI3, but not GLI1 or GLI2, restores DR4 expression and TRAIL sensitivity, indicating that the Hh effect is exclusively mediated by this transcription factor. In conclusion, these data provide evidence of a regulatory mechanism, which modulates TRAIL signaling in cancer cells and suggest new therapeutic approaches for TRAIL-resistant neoplasms. PMID:20562908

  6. GLI3-dependent repression of DR4 mediates hedgehog antagonism of TRAIL-induced apoptosis

    PubMed Central

    Kurita, S; Mott, JL; Almada, LL; Bronk, SF; Werneburg, NW; Sun, S-Y; Roberts, LR; Fernandez-Zapico, ME; Gores, GJ

    2010-01-01

    Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis through its cognate receptors death receptor 4 (DR4) and death receptor 5 (DR5), preferentially in malignant cells. However, many malignant cells remain resistant to TRAIL cytotoxicity by poorly characterized mechanisms. Here, using cholangiocarcinoma cells, as a model for TRAIL resistance, we identified a role for the oncogenic Hedgehog (Hh)-GLI pathway in the regulation of TRAIL cytotoxicity. Blockade of Hh using pharmacological and genetic tools sensitizes the cells to TRAIL cytotoxicity. Restoration of apoptosis sensitivity coincided with upregulation of DR4 expression, while expression of other death effector proteins remained unaltered. Knockdown of DR4 mimics Hh-mediated resistance to TRAIL cytotoxicity. Hh regulates the expression of DR4 by modulating the activity of its promoter. Luciferase, chromatin immunoprecipitation and expression assays show that the transcription factor GLI3 binds to the DR4 promoter and Hh requires an intact GLI3-repression activity to silence DR4 expression. Finally, small interfering RNA (siRNA)-targeted knockdown of GLI3, but not GLI1 or GLI2, restores DR4 expression and TRAIL sensitivity, indicating that the Hh effect is exclusively mediated by this transcription factor. In conclusion, these data provide evidence of a regulatory mechanism, which modulates TRAIL signaling in cancer cells and suggest new therapeutic approaches for TRAIL-resistant neoplasms. PMID:20562908

  7. Dr. James McGee shows three astronauts how to handle non-poisonous snake

    NASA Technical Reports Server (NTRS)

    1967-01-01

    Dr. James W. McGee (right), Medical Operations Office, Manned Spacecraft Center, shows three astronauts how to handle a non-poisonous snake during desert survival training in Washington state. Left to right, are Astronauts Thomas K. Mattingly, Alfred M. Worden, and John L. Swigert Jr.; and Dr. McGee. The astronauts are dressed in faked Arab clothing.

  8. 76 FR 14407 - Exchange of Letters Between Dr. Murray M. Lumpkin, Deputy Commissioner, International Programs...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-16

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration Exchange of Letters Between Dr. Murray M. Lumpkin, Deputy... providing notice of exchange of letters between Dr. Murray M. Lumpkin, Deputy Commissioner,...

  9. HLA-DR antigens in normal, inflammatory, and neoplastic salivary glands.

    PubMed

    Zarbo, R J; Regezi, J A; Lloyd, R V; Crissman, J D; Batsakis, J G

    1987-11-01

    A monoclonal antibody to HLA-DR antigens that is reactive in formalin-fixed tissues was used with the immunoperoxidase method to evaluate 212 salivary gland lesions (normal, nonspecific, and autoimmune inflammatory, benign, and malignant tumors). Results of immunostaining showed that (1) intercalated ducts, myoepithelial cells, and acinous cells of normal salivary glands express HLA-DR antigens, (2) autoimmune salivary gland disease results in greater HLA-DR expression than that seen in nonspecific inflammatory lesions or normal glands, (3) stromal cells associated with benign and malignant salivary gland tumors express HLA-DR antigens, and (4) numerous benign and malignant salivary gland tumors express HLA-DR antigens. It was of interest that lymphocyte-rich Warthin's tumors displayed epithelial immunoreactivity, whereas oncocytomas devoid of a lymphocytic component were invariably negative. This suggests a lymphocyte-mediated role in salivary epithelial HLA-DR expression. It appears that HLA-DR expression is both a normal and an inducible phenomenon in salivary glands, salivary gland neoplasia, and the desmoplastic host response. There is no discriminatory role in the immunologic detection of HLA-DR for differential diagnosis of salivary gland tumors.

  10. 105-DR Large Sodium Fire Facility decontamination, sampling, and analysis plan

    SciTech Connect

    Knaus, Z.C.

    1995-06-12

    This is the decontamination, sampling, and analysis plan for the closure activities at the 105-DR Large Sodium Fire Facility at Hanford Reservation. This document supports the 105-DR Large Sodium Fire Facility Closure Plan, DOE-RL-90-25. The 105-DR LSFF, which operated from about 1972 to 1986, was a research laboratory that occupied the former ventilation supply room on the southwest side of the 105-DR Reactor facility in the 100-D Area of the Hanford Site. The LSFF was established to investigate fire fighting and safety associated with alkali metal fires in the liquid metal fast breeder reactor facilities. The decontamination, sampling, and analysis plan identifies the decontamination procedures, sampling locations, any special handling requirements, quality control samples, required chemical analysis, and data validation needed to meet the requirements of the 105-DR Large Sodium Fire Facility Closure Plan in compliance with the Resource Conservation and Recovery Act.

  11. Psychometrics of the Drinker Inventory of Consequences (DrInC).

    PubMed

    Forcehimes, Alyssa A; Tonigan, J Scott; Miller, William R; Kenna, George A; Baer, John S

    2007-08-01

    The Drinker Inventory of Consequences (DrInC) was developed for Project MATCH to assess the consequences of drinking in five domains. The present study, using baseline data from the 1382 participants involved in the COMBINE Study, analyzed the psychometrics of the 50-item DrInC and its shorter form, the 15-item SIP. Findings indicate the DrInC is reliable, valid, and clinically useful and that DrInC subscales are internally consistent and non-redundant. In an examination of the shorter version of the DrInC, findings suggest that the SIP is suitable when assessing the overall level of drinking-related consequences.

  12. Human radiation studies: Remembering the early years. Oral history of Dr. Nadine Foreman, M.D., August 19, 1994

    SciTech Connect

    1995-07-01

    Dr. Nadine Foreman was interviewed by representatives of the US DOE Office of Human Radiation Experiments (OHRE). Dr. Foreman was selected for interview because of the position she held at the University of California, San Francisco. Following a brief biographical sketch, Dr. Foreman describes her work with Dr. Mayo Soley using I-131 in treatment of hyperthyroidism, selection criteria for patients in the radioiodine project, work with Dr. Earl Miller, work at Highland Hospital, radioiodine treatment of diffuse toxic goiter (myxedema), the radiophosphorus and radioiodine programs with Dr. Bert Low-Beer, and treatment of polycythemia vera.

  13. Low expression of human histocompatibility leukocyte antigen-DR is associated with hypermethylation of human histocompatibility leukocyte antigen-DR alpha gene regions in B cells from patients with systemic lupus erythematosus.

    PubMed Central

    Sano, H; Compton, L J; Shiomi, N; Steinberg, A D; Jackson, R A; Sasaki, T

    1985-01-01

    The relationship between the expression of HLA-DR antigens and the HLA-DR alpha gene methylation was examined in systemic lupus erythematosus (SLE). Using permanent B cell lines, we found reduced DR expression in SLE. The low DR expression was correlated with high anti-DNA antibody titers in patients' sera. The amounts of DR alpha message were lower in SLE cells than in normal controls, suggesting that the low expression of DR antigens is associated with gene functions. The extent of DNA methylation was examined at five CCGG sites in the HLA-DR alpha locus. DNA from both SLE and normal cells showed variable methylation patterns. Since the DR alpha gene is a single-copy gene, such a variability is the result of assaying a mixture of transformed clones containing methylated DR alpha gene, with other clones containing unmethylated DR alpha gene. A distinctive feature of normal cells was a consistent methylation pattern: 12 normal cell lines showed exactly the same pattern. In contrast, 28 SLE cell lines showed a cell-line-specific methylation, and hypermethylation at the DR alpha locus. The hypermethylation is often associated with transcriptionally inactive genes. Thus, our results suggest that (a) B cells with hypermethylated DR genes might express no or few DR antigens; (b) the ratio of cells with differently methylated DR genes is consistent in normal individuals, while, in SLE patients, cells with hypermethylated DR genes predominate, resulting in apparently reduced DR antigen expression; and (c) the aberrant DR expression could be associated directly with immunoregulatory dysfunctions in SLE disease. Images PMID:2997276

  14. [Life and work of Dr. Jovan Jovanović Zmaj].

    PubMed

    Lesić, Aleksandar; Bumbasirević, Marko; Zizić-Borjanović, Slavica

    2006-10-01

    The year of 2004 was the 100th anniversary of death of the poet and physician Dr. Jovan Jovanović Zmaj. Jovan Jovanović Zmaj was born in 1833 in Novi Sad, and died in 1904 in Sremska Kamenica J.J. Zmaj himself studied law and worked in the Novi Sad magistrate court. It was not until he turned 30 that he began practicing medicine. He developed as a poet as early as during his studies. He remained loyal to the vocations of physician and poet throughout his life. He wrote over 5000 poems, ranging from those for children through those for adults and those with which he addressed the rulers satirically. He was a founder of a number of magazines (Javor, Neven, Komarac, Danica). At that time of Romanticism, the work of J.J. Zmaj also had a national character. However, he succeeded in achieving something more: he introduced a literary genre till then unknown in Serb literature--literature for children. Through his genre he promoted not only Serbian language but also hygiene, by which he played a significant health care role, similar to that played by his friend Milan Jovanović Batut, only from a different aspect. He also used to draw, and his drawing of the emblem of the Serbian Literary Association has remained on the cover of every book published by it until these days. PMID:18172968

  15. "Treating Lungs": The Scientific Contributions of Dr. Theodor Kolobow.

    PubMed

    Trahanas, John M; Kolobow, Mary Anne; Hardy, Mark A; Berra, Lorenzo; Zapol, Warren M; Bartlett, Robert H

    2016-01-01

    We are fortunate to live in an age in which biomedical technology has provided us with unprecedented ability to supplant the functions of organs and support the physiologic processes of the human body. Ingenious doctors, physiologists, and engineers helped create these advances with new and innovative ideas. One of these pioneers was Dr. Theodor Kolobow. He is best known for one of his earliest inventions, the spiral coil membrane lung. His contributions to medical innovation, however, are diverse, as he also contributed to advances in hemodialysis, improvements in extracorporeal life support technology/circuit components, and through his laboratory experiments helped shape our current understanding of cardiopulmonary pathophysiology. In retrospect, much of Kolobow's work was unified by the theme of preventing iatrogenic lung injury caused by mechanical ventilation. This tenet became more obvious as his later studies progressed to developing techniques and devices intended to limit ventilator pressures, and prevent bacterial colonization of the lungs. Although he formally retired from his research endeavors in 2009, the impact of his contributions remains prominent in our everyday use of techniques and equipment that he either originated or helped to develop. PMID:26720733

  16. 2012 DR30, The Most Distant Solar System Object

    NASA Astrophysics Data System (ADS)

    Kiss, Csaba; Szabó, G.; Pál, A.; Kiss, L.; Sárneczky, K.; Müller, T.; Vilenius, E.; Santos-Sanz, P.; Lellouch, E.; Conn, B.; Ortiz, J.; Duffard, R.; Morales, N.; Horner, J.; Bannister, M.; Stansberry, J.

    2012-10-01

    2012 DR30, the most distant TNO in the Solar System (a=1103 AU) has recently been observed with the Herschel Space Observatory. Radiometric model results using the far-infrared fluxes and visual range data show a dark and cratered surface (p_V = 6%) and provide a diameter of 200km. If considered as a Centaur, this is the fifth largest object known in this dynamical class. Recent visual range measurements indicate the presence of methane ice on the surface, a feature that has been seen previously for objects with diameters of >=1000km only (like Eris, Makemake and Pluto). The presence of methane ice can be explained assuming that the object spent most of its lifetime in a very cold environment and has been recently placed to its present orbit. This scenario is in agreement with the results of a dynamical study of the object's orbit, also suggesting an Oort-cloud origin. This research has been supported by the following grants: (1) The PECS program of the European Space Agency (ESA) and the Hungarian Space Office, PECS-98073; (2) C.K. and A.P. acknowledges the support of the Bolyai Research Fellowship of the Hungarian Academy of Sciences.

  17. Reflections of a soon-to-be former DR

    SciTech Connect

    Larson, N.I.

    1997-12-31

    SRP, formerly known as Salt River Project, is actually a combination of two organizations, The Salt River Valley Water Users` Association (the {open_quotes}Association{close_quotes}), and the Salt River Project Agricultural Improvement and Power District (the {open_quotes}District{close_quotes}). The Association was incorporated under the laws of the Territory of Arizona in 1903, and is one of the first projects authorized under the Federal Reclamation Act of 1902. The District was formed in 1937 as a political subdivision of the State of Arizona, and is responsible for the construction, operation and maintenance of the Electric System and the irrigation and water supply system. Generation and sale of electrical power and energy represent a significant portion of the District`s investment and revenues. SRP has a total capability of over 5000 MW from hydroelectric, thermal and purchased sources, Of this, almost 2400 MW is provided by Title IV, Phase II affected units. Phase II units must comply with the SO{sub 2} allowance program starting in the year 2000. SRP operates four facilities having Title IV units. The implementation of Title IV requires the selection of a Designated Representative (DR) to represent the utility and all utilities in the participation plants the utility may operate, to be responsible for reporting emissions of sulfur dioxide and oxides of nitrogen to the United States Environmental Protection Agency on a quarterly and annual basis and certify to the accuracy and completeness of the information.

  18. Candidate members of star clusters from LAMOST DR2

    NASA Astrophysics Data System (ADS)

    Zhang, Bo; Chen, Xiao-Yan; Liu, Chao; Chen, Li; Deng, Li-Cai; Hou, Jin-Liang; Shao, Zheng-Yi; Yang, Fan; Wu, Yue; Yang, Ming; Zhang, Yong; Hou, Yong-Hui; Wang, Yue-Fei

    2015-08-01

    In this work, we provide 2189 photometrically- and kinematically-selected candidate members of 24 star clusters from the LAMOST DR2 catalog. We perform two-step membership identification: selection along the stellar track in the color-magnitude diagram, i.e., photometric identification, and selection from the distribution of radial velocities, i.e. the kinematic identification. We find that the radial velocities from the LAMOST data are very helpful in the membership identification. The mean probability of membership is 40% for the sample selected with radial velocity. With these 24 star clusters, we investigate the performance of the radial velocity and metallicity estimated with the LAMOST pipeline. We find that the systematic offsets in radial velocity and metallicity are 0.85 ± 1.26 km s-1 and -0.08 ± 0.04 dex, with dispersions of 5.47+1.16-0.71 km s-1 and 0.13+0.04-0.02 dex, respectively. Finally, we propose that the photometrically-selected candidate members of the clusters covered by the LAMOST footprint should be assigned higher priority so that more candidate stars can be observed.

  19. 2011 AMCA Memorial Lecture honoree: Dr. Harrison Gray Dyar Jr.

    PubMed

    Carpenter, Terry L; Klein, Terry A

    2011-09-01

    Dr. Harrison Gray Dyar Jr. (1866-1929) was an early-20th-century expert in taxonomy and biology of culicid Diptera. At an early age, Dyar became interested in the biology, life history, and taxonomy of Lepidoptera, which he continued throughout his entire career. Dyar pursued his passion for entomology, and during his formative years, professionals sent Lepidoptera specimens to him for identification. As his prominence was well known to Leland Howard, then the honorary curator of the US National Museum of Natural History, he was asked and accepted the position as honorary custodian of Lepidoptera in 1897, which later included periods of service with the US Department of Agriculture Bureau of Entomology and the US Army Officers' Reserve Corps. This position went without stipend and it was Dyar's personal wealth that allowed him to continue his love of entomology. However, the museum did provide limited staff and funds for illustrators, supplies, and travel. In the early 1900s, his interests expanded to include mosquitoes where he concentrated on their life histories and taxonomy. Throughout his career, Dyar often criticized colleagues, both personally and in publications, often with interludes of peace to coauthor articles and books. His legacy of original scientific work is of lasting significance to public health and entomology communities, in recognition of which he was selected as the 2011 AMCA memorial lecture honoree. PMID:22017104

  20. Identification of the HLA-DM/HLA-DR interface.

    PubMed

    Davies, Matthew N; Lamikanra, Abigail; Sansom, Clare E; Flower, Darren R; Moss, David S; Travers, Paul J

    2008-02-01

    Human leukocyte antigen (HLA)-DM is a critical participant in antigen presentation that catalyzes the dissociation of the Class II-associated Invariant chain-derived Peptide (CLIP) from the major histocompatibility complex (MHC) Class II molecules. There is competition amongst peptides for access to an MHC Class II groove and it has been hypothesised that DM functions as a 'peptide editor' that catalyzes the replacement of one peptide for another within the groove. It is established that the DM catalyst interacts directly with the MHC Class II but the precise location of the interface is unknown. Here, we combine previously described mutational data with molecular docking and energy minimisation simulations to identify a putative interaction site of >4000A2 which agrees with known point mutational data for both the DR and DM molecule. The docked structure is validated by comparison with experimental data and previously determined properties of protein-protein interfaces. A possible dissociation mechanism is suggested by the presence of an acidic cluster near the N terminus of the bound peptide. PMID:17870168

  1. Dr. Monaco Examines Lab-on a-Chip

    NASA Technical Reports Server (NTRS)

    2003-01-01

    Dr. Lisa Monaco, Marshall Space Flight Center's (MSFC's) project scientist for the Lab-on-a-Chip Applications Development (LOCAD) program, examines a lab on a chip. The small dots are actually ports where fluids and chemicals can be mixed or samples can be collected for testing. Tiny channels, only clearly visible under a microscope, form pathways between the ports. Many chemical and biological processes, previously conducted on large pieces of laboratory equipment, can now be performed on these small glass or plastic plates. Monaco and other researchers at MSFC in Huntsville, Alabama, are customizing the chips to be used for many space applications, such as monitoring microbes inside spacecraft and detecting life on other planets. The portable, handheld Lab-on-a Chip Application Development Portable Test System (LOCAD-PTS) made its debut flight aboard Discovery during the STS-116 mission launched December 9, 2006. The system allowed crew members to monitor their environment for problematic contaminants such as yeast, mold, and even E.coli, and salmonella. Once LOCAD-PTS reached the International Space Station (ISS), the Marshall team continued to manage the experiment, monitoring the study from a console in the Payload Operations Center at MSFC. The results of these studies will help NASA researchers refine the technology for future Moon and Mars missions. (NASA/MSFC/D.Stoffer)

  2. Three moving groups detected in the LAMOST DR1 archive

    SciTech Connect

    Zhao, J. K.; Zhao, G.; Chen, Y. Q.; Tan, K. F.; Oswalt, T. D.; Zhang, Y. E-mail: oswaltt1@erau.edu

    2014-05-20

    We analyze the kinematics of thick disk and halo stars observed by the Large Sky Area Multi-Object Fiber Spectroscopic Telescope. We have constructed a sample of 7993 F, G, and K nearby main-sequence stars (d < 2 kpc) with estimates of position (x, y, z) and space velocity (U, V, W) based on color and proper motion from the Sloan Digital Sky Survey DR9 catalog. Three 'phase-space overdensities' are identified in (V, √(U{sup 2}+2V{sup 2})) with significance levels of σ > 3. Two of them (the Hyades-Pleiades stream and the Arcturus-AF06 stream) have been identified previously. We also find evidence for a new stream (centered at V ∼ –180 km s{sup –1}) in the halo. The formation mechanisms of these three streams are analyzed. Our results support the hypothesis that the Arcturus-AF06 stream and the new stream originated from the debris of a disrupted satellite, while the Hyades-Pleiades stream has a dynamical origin.

  3. Kinematics and activity of M dwarfs in LAMOST DR1

    NASA Astrophysics Data System (ADS)

    Yi, Zhen-Ping; Luo, A.-Li; Zhao, Jing-Kun; Song, Yi-Han; Pan, Jing-Chang; Zhao, Yong-Heng; Zhang, Yong

    2015-06-01

    We report on the first investigation into kinematics and chromospheric activity of M dwarfs from the Guo Shou Jing Telescope (also called the Large Sky Area Multi-Object Fiber Spectroscopic Telescope - LAMOST) data release one (DR1). The sample comprises 71 304 M dwarfs. Their fundamental parameters such as spectral types, radial velocities, important molecular band indices and magnetic activities are measured. Their distances are determined by a spectroscopic parallax relation. Space motion (U, V, W) and Galactocentric cylindrical coordinates (R, θ, Z) for the M dwarfs are also computed. We examine velocity dispersion as a function of height from the Galactic plane and find that all three components of velocity dispersion increase with height as measured with respect to the Galactic plane. The investigation into chromospheric activities along the height from the Galactic plane confirms that M dwarfs closer to the Galactic plane are more likely to be active. We take a pure kinematical approach to select thin disk stars and thick disk stars from our sample, then to investigate the differences in properties between these two populations. Our analysis is in excellent agreement with previous studies and leads to a better understanding of the structure of the Galactic disk. Supported by the National Natural Science Foundation of China.

  4. 2015 AMCA Memorial Lecture Honoree: Dr. Richard Floyd Darsie, Jr.

    PubMed

    Day, Jonathan F

    2015-12-01

    Richard Floyd Darsie, Jr. (1915-2014) is the 2015 American Mosquito Control Association Memorial Lecture Honoree. He was one of the greatest mosquito taxonomists of the 20th century and died peacefully on April 10, 2014, in Grove City, PA, at the age of 99 after a professional career that spanned eight decades. Dick's broad areas of interest and training made him a versatile scientist, teacher, and researcher. His intense interest in adult and immature mosquito morphology and taxonomy, as well as mosquito distribution and bionomics, started early in his career at two early academic postings: Franklin and Marshall College (1949-54) and the University of Delaware (1954-62). Dick would take his mosquito interests with him to postings and research projects around the world: Nepal, the Philippines, Atlanta, El Salvador, Guatemala, Fort Collins, South Carolina, Argentina, and Florida. His travels and studies would make him an international expert on mosquito taxonomy. Dick's legacy lives on in the hundreds of students from across the globe who learned mosquito identification skills from this world-renowned mosquito taxonomist. All will proudly profess that, "I learned mosquito identification from Dr. Darsie." And that is all that is needed to prove one's credentials in the field, learning the art from the best there is. PMID:26675466

  5. The life-work of Prof. MUDr. Zdenek Lojda, Dr.Sc., Dr. Med. et Iur. h.c.

    PubMed

    Hach, P

    2008-01-01

    Professor Zdenek Lojda, MD., Dr.Sc., Dr. Med.h.c., Dr. Jur. h.c., vice-rector emeritus of the Charles University and director emeritus of the Institute of Histology and Embryology of the 1st Medical Faculty of the Charles University in Prague died on the 24th April 2004. Born in Trebíc (in a local maternal hospital on the 7th December 1927) he grew up in Moravské Budejovice where he graduated from a primary and secondary school (he passed out each class as well as the leaving exam at the local gymnasium in 1946 cum laude). He was growing up in an inspiring atmosphere of a family of a professor at gymnasium that helped him to form his fundamental moral attitude and to gain high knowledge of an almost Renaissance comprehension. He was a gifted linguist (he spoke fluently several languages including Latin) and musician (he did community singing among others) and he was interested in natural sciences. In 1946 he enrolled for the medical faculty and coincidentally he was grouped among students that completed histology and embryology at the Institute of Embryology headed by professor Zdenek Frankenberger, MD., who had recognised his interest in this field of study. The young student gave himself and his free time to the work of an unqualified lab-worker and only later he became assistant conducting practical tutorials. He took his degree cum laude in 1952 and he received certificate of competence because of his excellent results. He showed his preoccupation with histology (strongly influenced by the personality of professor Frankenberger) after the graduation when he entered the job of the assistant professor at the Institute of Embryology and he stayed there until 1961. When he was about to decide which problems he should target, professor Frankenberger drew his attention to a very interesting part of histology that was just in advance and that was the use of diazonic salts for formation of colour reaction product demonstrating enzyme activity in tissues. In 1962

  6. The life-work of Prof. MUDr. Zdenek Lojda, Dr.Sc., Dr. Med. et Iur. h.c.

    PubMed

    Hach, P

    2008-01-01

    Professor Zdenek Lojda, MD., Dr.Sc., Dr. Med.h.c., Dr. Jur. h.c., vice-rector emeritus of the Charles University and director emeritus of the Institute of Histology and Embryology of the 1st Medical Faculty of the Charles University in Prague died on the 24th April 2004. Born in Trebíc (in a local maternal hospital on the 7th December 1927) he grew up in Moravské Budejovice where he graduated from a primary and secondary school (he passed out each class as well as the leaving exam at the local gymnasium in 1946 cum laude). He was growing up in an inspiring atmosphere of a family of a professor at gymnasium that helped him to form his fundamental moral attitude and to gain high knowledge of an almost Renaissance comprehension. He was a gifted linguist (he spoke fluently several languages including Latin) and musician (he did community singing among others) and he was interested in natural sciences. In 1946 he enrolled for the medical faculty and coincidentally he was grouped among students that completed histology and embryology at the Institute of Embryology headed by professor Zdenek Frankenberger, MD., who had recognised his interest in this field of study. The young student gave himself and his free time to the work of an unqualified lab-worker and only later he became assistant conducting practical tutorials. He took his degree cum laude in 1952 and he received certificate of competence because of his excellent results. He showed his preoccupation with histology (strongly influenced by the personality of professor Frankenberger) after the graduation when he entered the job of the assistant professor at the Institute of Embryology and he stayed there until 1961. When he was about to decide which problems he should target, professor Frankenberger drew his attention to a very interesting part of histology that was just in advance and that was the use of diazonic salts for formation of colour reaction product demonstrating enzyme activity in tissues. In 1962

  7. Morphology and Absolute Magnitudes of the SDSS DR7 QSOs

    NASA Astrophysics Data System (ADS)

    Coelho, B.; Andrei, A. H.; Antón, S.

    2014-10-01

    The ESA mission Gaia will furnish a complete census of the Milky Way, delivering astrometrics, dynamics, and astrophysics information for 1 billion stars. Operating in all-sky repeated survey mode, Gaia will also provide measurements of extra-galactic objects. Among the later there will be at least 500,000 QSOs that will be used to build the reference frame upon which the several independent observations will be combined and interpreted. Not all the QSOs are equally suited to fulfill this role of fundamental, fiducial grid-points. Brightness, morphology, and variability define the astrometric error budget for each object. We made use of 3 morphological parameters based on the PSF sharpness, circularity and gaussianity, which enable us to distinguish the "real point-like" QSOs. These parameters are being explored on the spectroscopically certified QSOs of the SDSS DR7, to compare the performance against other morphology classification schemes, as well as to derive properties of the host galaxy. We present a new method, based on the Gaia quasar database, to derive absolute magnitudes, on the SDSS filters domain. The method can be extrapolated all over the optical window, including the Gaia filters. We discuss colors derived from SDSS apparent magnitudes and colors based on absolute magnitudes that we obtained tanking into account corrections for dust extinction, either intergalactic or from the QSO host, and for the Lyman α forest. In the future we want to further discuss properties of the host galaxies, comparing for e.g. the obtained morphological classification with the color, the apparent and absolute magnitudes, and the redshift distributions.

  8. Dr. Nicholas Ionescu-Pallas at His 70-th Anniversary

    NASA Astrophysics Data System (ADS)

    Vlad, Valentin I.

    The article is devoted to 70-th Anniversary of Dr. Nicholas Ionescu-Pallas (borne on July 30, 1932 in Pallas village close to the town of Constanţa, Romania as the son of Ion Ionescu and Maria Dincă), an outstanding Romanian physicist with contributuions in a large area of theoretical and experimental physics, from Theoretical Classical and Quantum Mechanics to General Relativity and Gravitation. He was graduated from the University of Bucharest (1955), a disciple of Professor Ion Agârbiceanu, Doctor of Physics in 1971. He is the author of more than 300 scientific papers and 3 fundamental monographs in these areas, unique in Romania, and of great international circulation. He was one of the creators of the First Romanian Laser. He was elected the Honorary President of the Romanian Society on Genereal Relativity and Gravitation. A great erudition by Ionescu-Pallas allowed him to make also contributions in History of Sciencs. He has been a member of the Academic Commitee for the Philosophy and history of science, of the European Physical Society (1971), of the European Group for Atomic spectroscopy (1970), of the Institute for Scientific Culture E. Majorana (1976), of the International Society of Gravitation and General Relativity (1978) and of the Astronomical Society of India (1982). He was a representative of the intellectuals in the Scientific Council of the Institute for Atomic Physics, 1970-1975; a member of the National Commitee for physics in 1970, and a member of the Coordinating Commitee for the Romanian Enclclopaedia of Physics in 1983. His biographical data are available in Men of Achievement, Who's Who in the World, and Short History of the Romanian Scientific and Technical Creativeness.

  9. Dose reduction using prior image constrained compressed sensing (DR-PICCS)

    NASA Astrophysics Data System (ADS)

    Tang, Jie; Thériault Lauzier, Pascal; Chen, Guang-Hong

    2011-03-01

    A technique for dose reduction using prior image constrained compressed sensing (DR-PICCS) in computed tomography (CT) is proposed in this work. In DR-PICCS, a standard FBP reconstructed image is forward projected to get a fully sampled projection data set. Meanwhile, it is low-pass filtered and used as the prior image in the PICCS reconstruction framework. Next, the prior image and the forward projection data are used together by the PICCS algorithm to obtain a low noise DR-PICCS reconstruction, which maintains the spatial resolution of the original FBP images. The spatial resolution of DR-PICCS was studied using a Catphan phantom by MTF measurement. The noise reduction factor, CT number change and noise texture were studied using human subject data consisting of 20 CT colonography exams performed under an IRB-approved protocol. In each human subject study, six ROIs (two soft tissue, two colonic air columns, and two subcutaneous fat) were selected for the CT number and noise measurements study. Skewness and kurtosis were used as figures of merit to indicate the noise texture. A Bland-Altman analysis was performed to study the accuracy of the CT number. The results showed that, compared with FBP reconstructions, the MTF curve shows very little change in DR-PICCS reconstructions, spatial resolution loss is less than 0.1 lp/cm, and the noise standard deviation can be reduced by a factor of 3 with DR-PICCS. The CT numbers in FBP and DR-PICCS reconstructions agree well, which indicates that DR-PICCS does not change CT numbers. The noise textures indicators measured from DR-PICCS images are in a similar range as FBP images.

  10. Combined use of RFLP and PCR-ASO typing for HLA-DR-Dw and DQw typing.

    PubMed

    Bignon, J D; Bidwell, J L

    1991-01-01

    Due to some limitations of restriction fragment length polymorphism (RFLP) analysis in HLA-DR-DQ typing, we present a combined use of RFLP and polymerase chain reaction (PCR)-allele-specific oligonucleotide (ASO) typing. This scheme consists in selectively amplifying the few RFLP ill-defined genes (DR1/DR'Br' and DR4-Dw subsets) using PCR with allele specific primers to avoid cross-hybridization. PMID:1676910

  11. Dr. John Frederick May and the identification of John Wilkes Booth's body.

    PubMed

    Spiegel, A D

    1998-10-01

    Shortly after President Abraham Lincoln's assassin was killed on April 26, 1865, a formal inquest was held to positively identify the body. Dr. John Frederick May, a leading surgeon in the District of Columbia, was summoned to examine the remains. Two years earlier, Dr. May had removed a fibroid tumor from the back of the assassin's neck and an identifiable large ugly scar resulted when the wound inadvertently opened and healed by granulation. Based upon the recognition of the scar made by his scalpel, Dr. May made a positive identification. PMID:9793835

  12. Dr. Ray Gause examines student Skylab experiment ED-52 Web Formation

    NASA Technical Reports Server (NTRS)

    1973-01-01

    Dr. Ray Gause of the NASA-Marshall Space Flight Center (MSFC) places dinner, in the form of a housefly, in the web of Arabella - the prime spider for the ED-52 Web Formation Experiment. Arabella can be delineated near the end of the black pen in Dr. Gause's hand. The experiment is one of 25 student experiments accepted for the Skylab program and will be performed during the Skylab 3 mission. Judy Miles, a 17-year-old high school student from Lexington, Massachusetts, is the student experimenter and Dr. Gause is the NASA student advisor.

  13. Ask Dr. Sue--Updates: Infectious Diseases, SIDS, HIV/AIDS.

    ERIC Educational Resources Information Center

    Aronson, Susan S.

    1995-01-01

    Describes new concerns about infectious diseases in childcare settings (tuberculosis, gastrointestinal infections, and lice); sleep position and SIDS; HIV/AIDS issues; and the use of sterilized sand in sand boxes. (DR)

  14. Eye-Eye with Dr. Rachel Bishop | NIH MedlinePlus the Magazine

    MedlinePlus

    ... this page please turn JavaScript on. Feature: Glaucoma Eye-to-Eye with Dr. Rachel Bishop Past Issues / Spring 2015 ... new patient comes in because they scratched their eye while working in the yard, or they think ...

  15. The role of HLA-DR antigens in PPD-stimulated lymphocyte-monocyte interactions.

    PubMed

    Haar, D; Heron, I

    1982-11-01

    Autologous monocytes are required for an optimal lymphocyte proliferative response to purified protein derivate of tuberculin (PPD) in vitro and for a mixed lymphocyte culture induced by alloantigens. In the proliferative response to PPD we found that autologous monocytes could be replaced with HLA-DR-compatible monocytes and partly with HLA-DR semi-identical. In spite of a statistically significant difference between autologous and HLA-DR disparate monocytes in their cooperative capacity with PPD-stimulated lymphocytes, replacement in nearly one third of the cases was possible. These findings were supported by more detailed studies in which increasing numbers of allogenic and autologous monocytes were added to the isolated lymphocytes in the presence of PPD. It is concluded that the serologically defined HLA-DR antigens alone give insufficient information of the restriction elements controlling the PPD-stimulated lymphocyte-monocyte interactions. PMID:6184773

  16. [Dr. Eva Haljecka (18??-1947), the first female obstetrician-gynecologist in the Yugoslav countries].

    PubMed

    Berić, B M

    1983-01-01

    The author presents data on the first women obstetricians and gynecologists in the Yugoslav countries. Their work started in Belgrade in the last decade of the 19th century (Dr Eva Haljecka in 1892 and Dr Ljubica Godevac-Durić in 1896). The life, work, and other biographical data concerning Dr E. Haljecka (1869-1947) are given in more detail. She was the first woman obstetrician-gynecologist not only in Belgrade, Nis and the whole of Serbia but also in all Yugoslav countries. In 1920 she became the first head of the Gynecologico-Obstetric Department of the Nis Hospital, where she had worked since 1910. Before the First World War Dr E. Haljecka distinguished herself as a prominent fighter for the social and other rights and equality of women physicians in the then Kingdom of Serbia.

  17. High Blood Cholesterol Q&A Dr. Michael Lauer | NIH MedlinePlus the Magazine

    MedlinePlus

    ... this page please turn Javascript on. Feature: High Cholesterol High Blood Cholesterol Q&A with Dr. Michael Lauer Past Issues / ... heavier and older, what does recent research on cholesterol and heart health tell us that Americans need ...

  18. Dr Mary Crosse, OBE, MD (1900–1972) and the premature baby

    PubMed Central

    Dunn, P M

    2007-01-01

    On behalf of Birmingham's Department of Public Health, Dr Crosse developed the Sorrento Premature Baby Unit in 1931 and pioneered the modern care of these small newborn infants in Britain. PMID:17337665

  19. ISS Update: Dr. Steve Squyres, NEEMO 16 Aquanaut and Cornell Professor

    NASA Video Gallery

    ISS Update Commentator Pat Ryan interviews Dr. Steve Squyres, NEEMO 16 Aquanaut and Cornell Professor, about simulating a mission to an asteroid underwater. The Aquarius habitat simulates the isola...

  20. Profiles in Performing Arts Medicine Courage--A Tribute to Dr. Alice Brandfonbrener.

    PubMed

    Manchester, Ralph A

    2015-09-01

    I was honored and privileged to join Dr. Robert Sataloff in delivering a tribute to Dr. Alice Brandfonbrener at the 2015 Symposium on the Medical Problems of Performing Artists in Snowmass, Colorado. As virtually everyone who reads this journal knows, Dr. Brandfonbrener organized the first symposium (then focused on the medical problems of musicians), was the founding editor of Medical Problems of Performing Artists, and was the first president of the Performing Arts Medicine Association. She died in 2014, just prior to last year's symposium. This year, after Dr. Sataloff presented a very engaging overview of Alice's career and impressive accomplishments, I gave a short address that was based on some of the editorials Alice wrote in this journal during her 20 year tenure as editor. I have chosen a few examples of how the courage that she demonstrated in launching an international medical conference, a peer-reviewed medical journal, and a professional association continued to present itself in her writing.

  1. Dr. Louis Sullivan: Treating America's Most Critical Health and Human Services Ills.

    ERIC Educational Resources Information Center

    Cox, William E,; Matthews, Frank L.

    1989-01-01

    Interview with Dr. Louis Sullivan, Secretary of Health and Human Services. Discusses his views on health education, budget, access to health care, minority health, abortion, infant mortality, drugs, the Head Start Program, federal planning effects, and family influences. (JS)

  2. Dr. Grant Heikan examines lunar material in sieve from sample container

    NASA Technical Reports Server (NTRS)

    1969-01-01

    Dr. Grant Heikan, Manned Spacecraft Center and a Lunar Sample preliminary Examination Team member, examines lunar material in a sieve from the bulk sample container which was opened in the Biopreparation Laboratory of the Lunar Receiving Laboratory.

  3. President Kennedy, Vice President Johnson and Dr. von Braun at Redstone Airfield

    NASA Technical Reports Server (NTRS)

    1962-01-01

    President John F. Kennedy, Vice President Lyndon B. Johnson and Marshall Space Flight Center Director Dr. Wernher von Braun at the Redstone Arsenal Airfield, September 11, 1962. Kennedy and Johnson visited the Marshall Center to tour national space facilities.

  4. New NIH Director Dr. Francis Collins on Medical Research That Benefits Everyone's Health

    MedlinePlus

    ... version of this page please turn Javascript on. New NIH Director Dr. Francis Collins on Medical Research ... Our goal is to advance biomedical research in new, innovative ways that will benefit everyone's health." — NIH ...

  5. VISIT TO DR SHARP - BEN PINKEL - ABE SILVERSTEIN - OSCAR SCHEY - JESSE HALL - JOHN COLLINS BY CONGRE

    NASA Technical Reports Server (NTRS)

    1949-01-01

    VISIT TO DR SHARP - BEN PINKEL - ABE SILVERSTEIN - OSCAR SCHEY - JESSE HALL - JOHN COLLINS BY CONGRESSMAN CARL HENSHAW FROM CALIFORNIA - NORWICK ROSS DEPARTMENT OF COMMERCE - SENOR BUCH DE PERADA REPRESENTATIVE FROM MEXICO -

  6. Dr. Michael DeBakey "is a magician of the heart…"

    MedlinePlus

    ... Home Current Issue Past Issues Then & Now Dr. Michael DeBakey "is a magician of the heart…" Past ... NLM's David Nash and admiring students from the Michael E. DeBakey High School for Health Professionals in ...

  7. Interview with ARPA-E Acting Director Dr. Cheryl Martin on Platts Energy Week

    ScienceCinema

    Martin, Cheryl; Loveless, Bill

    2016-07-12

    Bill Loveless from Platts Energy Week interviews ARPA-E Acting Director, Dr. Cheryl Martin, about the many transformational energy technologies on display at ARPA-E's 5th annual Energy Innovation Summit.

  8. APOLLO 14 DR. WERNHER VON BRAUN WATCHES FROM FIRING ROOM 2

    NASA Technical Reports Server (NTRS)

    1971-01-01

    Dr. Wernher von Braun, the NASA Deputy Associate Administrator for Future Programs, uses binoculars to monitor data on closed- circuit television screens in Firing Room 2 of the Launch Control Center during final Apollo 14 launch preparations today.

  9. Dr. Ravindra Lal follows a live downlink of experiments operations on shuttle

    NASA Technical Reports Server (NTRS)

    1985-01-01

    Dr. Ravindra Lal, principal investigator for a crystal growth experiment for Spacelab 3, follows a live downlink of the experiments operations in the shuttle science module. He is in the payload operations control center (POCC) in JSC's mission control center.

  10. Description of work for 100-DR-2 Operable Unit Vadose Drilling/test pits

    SciTech Connect

    Naiknimbalkar, N.

    1993-08-01

    This report describes the scope of work for the boreholes/test pits of the 100-DR-2 Operable Unit. Sampling and field activities include: Soil screening; geologic sampling; soil sampling (physical property); analytical sampling and depths; and geophysical logging.

  11. Interview with ARPA-E Acting Director Dr. Cheryl Martin on Platts Energy Week

    SciTech Connect

    Martin, Cheryl; Loveless, Bill

    2014-03-18

    Bill Loveless from Platts Energy Week interviews ARPA-E Acting Director, Dr. Cheryl Martin, about the many transformational energy technologies on display at ARPA-E's 5th annual Energy Innovation Summit.

  12. VizieR Online Data Catalog: Gaia DR1 (Gaia Collaboration, 2016)

    NASA Astrophysics Data System (ADS)

    Gaia Collaboration

    2016-06-01

    Gaia DR1 is based on observations collected between 25 July 2014 and 16 September 2015. Gaia DR1 contains positions (RA,DE) and G magnitudes for all sources with acceptable formal standard errors on positions. Positions and individual uncertainties are computed using a generic prior and Bayes' rule (detailed description in "Gaia astrometry for stars with too few observations. A Bayesian approach", Michalik et al., 2015A&A...583A..68M). The five-parameter astrometric solution - positions, parallaxes, and proper motions - for stars in common between the Tycho-2 Catalogue and Gaia is contained in Gaia DR1. This part of Gaia DR1 is based on the Tycho-Gaia Astrometric Solution (paper with detailed description (Michalik et al., 2015A&A...574A.115M); paper describing theory and background (Michalik et al., 2014A&A...571A..85M); paper describing quasar extension (Michalik & Lindegren, 2016A&A...586A..26M)). At the beginning of the routine phase, for a period of 4 weeks, a special scanning mode repeatedly covering the ecliptic poles on every spin was executed for calibration purposes. Photometric data of selected RR Lyrae and Cepheid variable stars based on these high-cadence measurements are contained in Gaia DR1. Positions (RA,DE) and G magnitudes for 2152 ICRF quasars (F. Mignard et al., 2016, A&A, in press.). The Gaia Archive DR1 data is available at archives.esac.esa.int/gaia. Tgas and Gaia Sources can be downloaded as VOTables, FITS or CSV at http://1016243957.rsc.cdn77.org/Gaia/ If you use public Gaia DR1 data in your paper, please take note of our guide on how to acknowledge and cite Gaia DR1: http://gaia.esac.esa.int/documentation/GDR1/Miscellaneous/\\ seccreditandcitationinstructions.html (9 data files).

  13. Differential expression of HLA-DR antigens in subsets of human CFU-GM.

    PubMed

    Griffin, J D; Sabbath, K D; Herrmann, F; Larcom, P; Nichols, K; Kornacki, M; Levine, H; Cannistra, S A

    1985-10-01

    Expression of HLA-DR surface antigens by granulocyte/monocyte colony-forming cells (CFU-GM) may be important in the regulation of proliferation of these cells. Using immunological techniques to enrich for progenitor cells, we investigated the expression of HLA-DR in subsets of CFU-GM. "Early" (day 14) CFU-GM express higher levels of HLA-DR than do "late" (day 7) CFU-GM. Among late CFU-GM, cells destined to form monocyte (alpha-naphthyl acetate esterase-positive) colonies express higher levels of HLA-DR than do CFU-GM destined to form granulocyte (chloroacetate esterase-positive) colonies. Because high-level expression of DR antigen was a marker for monocyte differentiation, we examined several lymphokines for their effects on both DR expression and in vitro commitment to monocyte differentiation by myeloid precursor cells. DR antigen density could be increased by more than twofold over 48 hours upon exposure to gamma-interferon (gamma-IFN), whereas colony-stimulating factors had no effect. This was associated with a dose-dependent inhibition of total CFU-GM number, and a relative, but not absolute, increase in the ratio of monocyte colonies to granulocyte colonies. Similarly, in day 7 suspension cultures of purified myeloid precursor cells, gamma-IFN inhibited cell proliferation and increased the ratio of monocytes to granulocytes. Thus, despite the induction of high levels of HLA-DR antigen on precursor cells (a marker of monocyte commitment), the dominant in vitro effect of gamma-IFN was inhibition of granulocyte differentiation.

  14. Limited field investigation report for the 100-DR-1 Operable Unit

    SciTech Connect

    Not Available

    1994-06-01

    This limited field investigation (LFI) report summarizes the data collection and analysis activities conducted during the 100-DR-1 Source Operable Unite LFI and the associated qualitative risk assessment (QRA), and makes recommendations on the continued candidacy of high-priority sites for interim remedial measures (IRM). The results and recommendations presented in this report are generally independent of future land use scenarios. The 100-DR-1 Operable Unit is one of four operable units associated with the 100 D/DR Area at the Hanford Site. The 100-DR-1 Operable Unit encompasses approximately 1.5 km{sup 2} (0.59 mi{sup 2}) and is located immediately adjacent to the Columbia River shoreline. In general, it contains waste facilities associated with the original plant facilities constructed to support D Reactor facilities, as well as cooling water retention basin systems for both D and DR Reactors. The 100-DR-1 LFI began the investigative phase of the remedial investigation for a select number of high-priority sites. The LFI was performed to provide additional data needed to support selection, design and implementation of IRM, if needed. The LFI included data compilation, nonintrusive investigations, intrusive investigations, summarization of 100 Area aggregate studies, and data evaluation.

  15. DR 21(OH), a cluster in the making. 1: Observations in carbon monosulphide and methanol

    NASA Astrophysics Data System (ADS)

    Richardson, K. J.; Sandell, G.; Cunningham, C. T.; Davies, S. R.

    1994-06-01

    The star formation region DR 21(OH) was observed in the J=5-4 transitions of CS and C34S, and in several J=5-4 transitions of methanol. High velocity wings are detected in CS towards the main DR 21(OH) peak, extending over 80 km/s. They are very faint, and the outer wings are detected only at the center position. Since the outflow is not seen in the CO J=1-0 or 2-1 transitions, the CS observations suggest that this is a young, compact, dense and hot outflow. Many of the known NH3 cores are also seen in CS and methanol. Three known submm-continuum sources, DR 21(OH)S, DR 21(OH)SW, and DR 21(OH)NW, are suprisingly faint in the CS J=5-4 line, probably because the gas, though sufficiently dense, is too cold to fully excite the CS J=5-4 transition. They are, however, strong in methanol. An additional source, DR 21(OH)SE, is strong in CS but weak in methanol. The methanol lines were interpreted with an local thermodynamic equilibrium (LTE) analysis to estimate rotational temperatures and column densities at the main peaks, and the results discussed in the context of chemical models.

  16. Dr John Dickinson (1832-1863): The man behind the bird.

    PubMed

    Conacher, I D

    2016-08-01

    The surgeon/naturalists Dr John Kirk, Dr Charles Meller and Dr John Dickinson, associated with the Zambezi Expedition (1857-1864) under the leadership of Dr David Livingstone are, like him, credited with the discovery of new species' of birds. A raptor, Falco dickinsoni, is named after Dr John Dickinson. Dickinson, born in the north east of England, trained in medicine in Newcastle upon Tyne. He volunteered to join the Universities' Mission to Central Africa and arrived as part of a second group to join Bishop Frederick Mackenzie, then attempting to build a Mission in Magomero, on the Shire Mountain Plateau in modern Malawi. Livingstone and Mackenzie had sown the seeds of disaster for the first UMCA venture while Dickinson was on his way to Central Africa, and his one meeting with Livingstone was trigger to a chain of events that threatened the whole expedition. Shortly after Dickinson's arrival in Magomero, Bishop Mackenzie and a fellow traveller, Reverend Henry de Wint Burrup, died. Magomero was abandoned and the remaining missionaries retrenched in Chibisa's Village on the River Shire. There, where Dickinson did most of his bird collecting, on 17 March 1863, he died of blackwater fever. Livingstone and Kirk were present at the burial. A marble cross at Chikwawa in Malawi is marker to the event that occurred on the day of Dr John Dickinson's 32nd birthday. PMID:24906404

  17. The structure of HLA-DR52c: Comparison to other HLA-DRB3 alleles

    SciTech Connect

    Dai, Shaodong; Crawford, Frances; Marrack, Philippa; Kappler, John W.

    2008-09-05

    Class II major histocompatibility complex (MHCII) molecules present antigens to CD4{sup +} T cells. In addition to the most commonly studied human MHCII isotype, HLA-DR, whose {beta} chain is encoded by the HLA-DRB1 locus, several other isotypes that use the same {alpha} chain but have {beta} chains encoded by other genes. These other DR molecules also are expressed in antigen-presenting cells and are known to participate in peptide presentation to T cells and to be recognized as alloantigens by other T cells. Like some of the HLA-DRB1 alleles, several of these alternate DR molecules have been associated with specific autoimmune diseases and T cell hypersensitivity. Here we present the structure of an HLA-DR molecule (DR52c) containing one of these alternate {beta} chains (HLA-DRB3*0301) bound to a self-peptide derived from the Tu elongation factor. The molecule shares structurally conserved elements with other MHC class II molecules but has some unique features in the peptide-binding groove. Comparison of the three major HLA-DBR3 alleles (DR52a, b, and c) suggests that they were derived from one another by recombination events that scrambled the four major peptide-binding pockets at peptide positions 1, 4, 6, and 9 but left virtually no polymorphisms elsewhere in the molecules.

  18. The life and contribution of Dr. Ronald Gitelman: a pioneer of modern chiropractic science

    PubMed Central

    Vernon, Howard

    2013-01-01

    Objective: The life and contribution to chiropractic science of Dr. Ronald Gitelman is reviewed. Methods: Sources for this article included review of the notes prepared by Dr. Joseph Keating in his “biography” of the Canadian Memorial Chiropractic College (CMCC); review of the important articles published by Dr. Gitelman; review of the important projects undertaken by him along with various colleagues; notes from reminiscences obtained from many of these colleagues and discussions with his family. Discussion: Dr. Gitelman’s academic career spanned from 1963 to the late 1980’s. During that time, he made foundational contributions to the development of chiropractic science including: developing the Archives (1974), the first collection of scientific articles supporting chiropractic science (which was subsequently published as the Chiropractic Archives Research Collection (CRAC)); delivering one of the few chiropractic papers at the seminal NINCDS conference (1975) and, developing the collaboration between CMCC and Dr. Kirkaldy-Willis at the University of Saskatoon (1976). He practiced in Toronto from 1961 to 2007. Summary: Dr. Gitelman was a pioneer in the development of chiropractic science. He died on October 7, 2012. PMID:23482630

  19. [Dr. Torafumi Okuyama, naval medical officer and the author of the dictionaries of medical terms].

    PubMed

    Fukase, Y

    1996-03-01

    Dr. Genryo Torafumi Okuyama, the second son of Dr. Genchu Okuyama of the Kaminoyama clan, was born on Dec. 4th, 1847. His elder brother Dr. Toraakira Okuyama was promoted to Dai Ikan (Senior Captain), the highest rank of medical officer in the Japanese Navy, and rendered distinguished services in the establishment of the naval medical systematization in the early Meiji era. Dr. Trafumi Okuyama, who was appointed as medical officer of the Yokohama army Hospital and transferred to Daibyoin in Edo, was engaged in medical treatment of injured soldiers during the Boshin-war in 1868. He went to Kagoshima with William Willis and as one of the founders of the Kagoshima Medical school, gave students education there. He resigned his naval position in 1874, when he was Dai Gun I (Senior Leutenant) and died at the age of 41 in April 16th 1887. Dr. Torafumi Okuyama compiled A medical vocabulary in English and Japanese ("Igo Ruizyu") and Deutsch-Japanisches Hand-Wörterbuch für Medizin ("Dokuwa Igaku Ziten) and published "Koen Hikki", the translation of the lectures by Dr. Edwin Wheeler. PMID:11618875

  20. Polymorphism of the HLA-D region in American blacks. A DR3 haplotype generated by recombination.

    PubMed

    Hurley, C K; Gregersen, P; Steiner, N; Bell, J; Hartzman, R; Nepom, G; Silver, J; Johnson, A H

    1988-02-01

    The polymorphism of HLA class II molecules in man is particularly evident when comparisons between population groups are made. This study describes a DR3 haplotype commonly present in the American black population. Unlike the Northern European population in which almost all DR3 individuals are DQw2, approximately 50% of DR3-positive American blacks express a serologically undefined DQ allelic product. DNA restriction fragment analysis with the use of several unrelated individuals and an informative family has allowed us to identify unique DQ alpha- and beta-fragments associated with the DR3, DQw- haplotype. Based on fragment size, the DQ alpha genes of the DR3, DQw- and DRw8, DQw- haplotypes are similar as are the DQ beta genes of DR3, DQw-; DRw8, DQw-; and DR4, DQw- haplotypes. In addition, a DX beta gene polymorphism has been identified which is associated with some DR3 haplotypes including the American black DR3, DQw- haplotype. cDNA sequence analysis has revealed a DQw2-like alpha gene and a DQ beta gene which is similar to that previously described for a DR4, DQw- haplotype. It is postulated that recombination between DQ alpha and DQ beta genes and between the DQ and DX subregions has generated the various DR3 haplotypes and has played an important role in creating diversity in the HLA-D region. PMID:2892884

  1. Contributions of Dr. George Washington Carver to global food security: historical reflections of Dr. Carver’s fungal plant disease survey in the southeastern United States

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Dr. George Washington Carver was a world renowned scientist whose research in the agricultural sciences in the late 1800’s and early 1900’s was critical for improving the living standards of American farmers especially in the southern United States. Although best known for developing the many uses o...

  2. Special issue dedicated in memory of Dr. Edward H. Ahrens, Jr.

    PubMed

    Ahrens, Edward H

    2002-01-01

    This special issue of the "Cardiovascular Drug Reviews" is dedicated in memory of Dr. Edward H. Ahrens, Jr., who died on Dec. 9th, 2000 at the Princeton Medical Center in New Jersey at the age of 85. Dr. Ahrens was the Director of the Lipid Metabolism Laboratory at the Rockefeller University. Dr. Alexander Scriabine conceived the idea for the issue at the special memorial symposium held at the Rockefeller University on Feb. 05, 2002 under the auspices of The New York Lipid and Vascular Biology Research Club. Dr. Ahrens was the first president of the club. He started this club with Drs. Howard Eder and DeWitt Goodman. Dr. Eder thought that it would be a fitting attribute to honor one of the founding fathers of the club by hosting a memorial symposium. I, as the President of the club for that academic year, had no hesitation in accepting the proposal. This year will be the 40th anniversary of the club and its continued success provides a glimpse of the fine legacy left behind by Dr. Ahrens. Dr. Ahrens also played a pivotal role in the establishment of the Journal of Lipid Research. This is the 43rd year of the journal and in this commemorative issue we are reproducing a review he wrote for the 25th anniversary of the journal. I was never personally acquainted with Dr. Ahrens. However, I am honored that I got this opportunity to pay tribute to a great scientist whose work has contributed immensely to the progress of lipid research. He was a person who touched many lives and still continues to do so. My involvement in the remembrance of Dr. Ahrens shows that science not only impacts your contemporaries but also generations that follow you. Scientific research is a journey where you can leave your trails behind and be remembered for your work long after your departure from this world. Dr. Ahrens contributed immensely to the understanding of cholesterol metabolism. In the early stages of his career he showed that phospholipids solubilize fat in the blood. Now we know

  3. Induction of pro-apoptotic antibodies to triple negative breast cancer by vaccination with TRAIL death receptor DR5 DNA

    PubMed Central

    Piechocki, Marie P.; Wu, Gen Sheng; Jones, Richard F.; Jacob, Jennifer B.; Gibson, Heather; Ethier, Stephen P.; Abrams, Judith; Yagita, Hideo; Venuprasad, K; Wei, Wei-Zen

    2012-01-01

    TNF-Related Apoptosis Inducing Ligand Receptor 2 (TRAIL-R2 or DR5) is expressed at elevated levels in a broad range of solid tumors to mediate apoptotic signals from TRAIL or agonist antibodies. We tested the hypothesis that DR5 DNA vaccination will induce pro-apoptotic antibody to trigger apoptosis of tumor cells. BALB/c mice were electrovaccinated with DNA encoding wild type human DR5 (phDR5) or its derivatives. Resulting immune serum or purified immune IgG induced apoptosis in triple negative breast cancer (TNBC) cells, which were also TRAIL-sensitive. The pro-apoptotic activity of immune serum at dilutions of 0.5-2% was comparable to that of 1-2 μg/ml of TRAIL. Apoptotic activity of immune serum was enhanced by antibody cross-linking. Apoptotic cell death induced by anti-DR5 antibody was shown by the cleavage of PARP and caspase-3. In contrast, immune serum had no effect on the proliferation of activated human T cells, which expressed low levels of DR5. In vivo, hDR5 reactive immune serum prevented growth of SUM159 TNBC cells in SCID mice. DR5 specific IFN-γ secreting T cells were also induced by DNA vaccination. Furthermore, the feasibility to overcome immune tolerance to self DR5 was shown by the induction of mouse DR5 binding antibody after electrovaccination of BALB/c mice with pmDR5ectm-Td1 encoding a fusion protein of mouse DR5 and an immunogenic fragment of tetanus toxin. These findings support DR5 as a promising vaccine target for controlling TNBC and other DR5 positive cancers. PMID:22419388

  4. High Temperature Superconductors: From Delivery to Applications (Presentation from 2011 Ernest Orlando Lawrence Award-winner, Dr. Amit Goyal, and including introduction by Energy Secretary, Dr. Steven Chu)

    SciTech Connect

    Goyal, Amit

    2012-05-22

    Dr. Amit Goyal, a high temperature superconductivity (HTS) researcher at Oak Ridge National Laboratory, was named a 2011 winner of the Department of Energy's Ernest Orlando Lawrence Award honoring U.S. scientists and engineers for exceptional contributions in research and development supporting DOE and its mission. Winner of the award in the inaugural category of Energy Science and Innovation, Dr. Goyal was cited for his work in 'pioneering research and transformative contributions to the field of applied high temperature superconductivity, including fundamental materials science advances and technical innovations enabling large-scale applications of these novel materials.' Following his basic research in grain-to-grain supercurrent transport, Dr. Goyal focused his energy in transitioning this fundamental understanding into cutting-edge technologies. Under OE sponsorship, Dr. Goyal co-invented the Rolling Assisted Bi-Axially Textured Substrate technology (RABiTS) that is used as a substrate for second generation HTS wires. OE support also led to the invention of Structural Single Crystal Faceted Fiber Substrate (SSIFFS) and the 3-D Self Assembly of Nanodot Columns. These inventions and associated R&D resulted in 7 R&D 100 Awards including the 2010 R&D Magazine's Innovator of the Year Award, 3 Federal Laboratory Consortium Excellence in Technology Transfer National Awards, a DOE Energy100 Award and many others. As a world authority on HTS materials, Dr. Goyal has presented OE-sponsored results in more than 150 invited talks, co-authored more than 350 papers and is a fellow of 7 professional societies.

  5. High Temperature Superconductors: From Delivery to Applications (Presentation from 2011 Ernest Orlando Lawrence Award-winner, Dr. Amit Goyal, and including introduction by Energy Secretary, Dr. Steven Chu)

    ScienceCinema

    Goyal, Amit (Oak Ridge National Laboratory)

    2016-07-12

    Dr. Amit Goyal, a high temperature superconductivity (HTS) researcher at Oak Ridge National Laboratory, was named a 2011 winner of the Department of Energy's Ernest Orlando Lawrence Award honoring U.S. scientists and engineers for exceptional contributions in research and development supporting DOE and its mission. Winner of the award in the inaugural category of Energy Science and Innovation, Dr. Goyal was cited for his work in 'pioneering research and transformative contributions to the field of applied high temperature superconductivity, including fundamental materials science advances and technical innovations enabling large-scale applications of these novel materials.' Following his basic research in grain-to-grain supercurrent transport, Dr. Goyal focused his energy in transitioning this fundamental understanding into cutting-edge technologies. Under OE sponsorship, Dr. Goyal co-invented the Rolling Assisted Bi-Axially Textured Substrate technology (RABiTS) that is used as a substrate for second generation HTS wires. OE support also led to the invention of Structural Single Crystal Faceted Fiber Substrate (SSIFFS) and the 3-D Self Assembly of Nanodot Columns. These inventions and associated R&D resulted in 7 R&D 100 Awards including the 2010 R&D Magazine's Innovator of the Year Award, 3 Federal Laboratory Consortium Excellence in Technology Transfer National Awards, a DOE Energy100 Award and many others. As a world authority on HTS materials, Dr. Goyal has presented OE-sponsored results in more than 150 invited talks, co-authored more than 350 papers and is a fellow of 7 professional societies.

  6. Assessment of DR-55 as a Drop-In Replacement for R-410A

    SciTech Connect

    Shen, Bo; Abdelaziz, Omar

    2016-01-01

    R410A has no ozone depletion potential (ODP), and is the most commonly used refrigerant in vapor compression systems for space cooling and heating applications. However, it has significant global warming potential with GWP higher than 1900. To mitigate the global warming effect, industry and research institutes are actively pursuing a replacement for R-410A with the following attributes, much lower GWP along with similar or higher efficiency and capacity. DR-55 (aka R452B) is a design-compatible refrigerant replacement for R-410A. It decreases the GWP by 70%, and has lower working pressure, comparable discharge temperature, and uses the same lubricant, tubing, and valves. In this study, we experimentally evaluated the performance of DR-55 as a drop-in replacement for R-410A in a high efficiency rooftop air conditioning unit. The experimental results demonstrated that DR-55 led to 5% higher efficiency at the working conditions of Integrated Energy Efficiency Rating (IEER). DR-55 also showed significantly better high ambient performance from 95 F to 125 F. In addition to the experimental study, we used the DOE/ORNL Heat Pump Design Model to model the RTU using R-410A and DR-55, respectively. The model results were compared to the laboratory measurements. The model validation demonstrates that the refrigerant heat transfer and pressure drop correlations, developed for conventional refrigerants like R-410A, are usable for DR-55. Also, a converted compressor model for DR-55, i.e. reducing volumetric and isentropic efficiencies as a function of the suction and discharge pressures from an R-410A compressor map can predict the compressor mass flow rate and power accurately.

  7. Death receptor-4 (DR4) expression is regulated by transcription factor NF-kappaB in response to etoposide treatment.

    PubMed

    Mendoza, Francisco José; Ishdorj, Ganchimeg; Hu, Xiaojie; Gibson, Spencer B

    2008-06-01

    Tumour necrosis factor related apoptosis inducing ligand (TRAIL) binds to death receptor 4 (DR4) activating the apoptotic signalling pathway. DNA damaging agents (genotoxins) such as etoposide increase DR4 expression and when combined with TRAIL induce a synergistic apoptotic response. The mechanism for up-regulation of DR4 expression following genotoxin treatment is not well understood. Herein, we determined that transcription factor NF-kappaB plays a role in genotoxin induced DR4 expression. Increased expression of DR4 following etoposide treatment is blocked by inhibition of the NF-kappaB pathway. Moreover, expression of the p65 subunit of NF-kappaB is sufficient to increase DR4 protein levels. Indeed, knockdown of p65 by RNA interference blocked etoposide up-regulation of DR4. We further identified a functional NF-kappaB binding site located in the DR4 promoter. Mutation of this site abrogates the induction of luciferase activity after p65 over-expression. Furthermore, electromobility shift assays and chromatin immunoprecipitaton suggest that NF-kappaB binds to this site upon etoposide treatment. MEK kinase 1 (MEKK1) is a serine threonine kinase that is activated following etoposide treatment and activates NF-kappaB. Expression of the kinase inactive MEKK1 (MEKK1-KM) abrogates the up-regulation of DR4 after etoposide treatment. Taken together, NF-kappaB plays a role in up-regulation of DR4 following etoposide treatment.

  8. Natural ligand motifs of closely related HLA-DR4 molecules predict features of rheumatoid arthritis associated peptides.

    PubMed

    Friede, T; Gnau, V; Jung, G; Keilholz, W; Stevanović, S; Rammensee, H G

    1996-06-01

    Rheumatoid arthritis (RA), one of the most common autoimmune disorders, is believed to be mediated via. T lymphocytes and genetic studies have shown that it is strongly associated with HLA-DR4. The DR4 subtypes DR4Dw4, DR4Dw14 and DR4Dw15 represent increased risk factors for RA, whereas DR4Dw10 is not associated with the disorder. Our study determines and compares the natural ligand motifs of these MHC class II molecules and identifies 60 natural ligands. At relative position 4 (P4), only the RA-associated DR4 molecules allow, or even prefer, negatively charged amino acids, but do not allow those which are positively charged (Arg, Lys). In the case of DR4Dw10 the preference for these amino acids is reversed. The results predict features of the putative RA-inducing peptide(s). A remarkable specificity, almost exclusively for negative charges (Asp, Glu), is found at P9 of the DR4Dw15 motif. This specificity can be ascribed to amino acid beta57 of the DR beta chain, and gives an important insight into the beta57-association of another autoimmune disease, insulin-dependent diabetes mellitus type I. PMID:8672555

  9. HLA-D region genes and rheumatoid arthritis (RA): importance of DR and DQ genes in conferring susceptibility to RA.

    PubMed Central

    Singal, D P; Green, D; Reid, B; Gladman, D D; Buchanan, W W

    1992-01-01

    The distribution of HLA-D region antigens was studied in three groups (I, IIa, and IIb) of patients with rheumatoid arthritis (RA): group I comprised 43 patients with mild, non-progressive RA, controlled by non-steroidal anti-inflammatory drugs without progression or erosions; group II comprised 94 patients with severe disease, who had earlier been treated with non-steroidal anti-inflammatory drugs and all had incomplete response requiring treatment with gold (sodium aurothiomalate). Of these, 46 patients (group IIa) responded to gold and the disease was well controlled, and the remaining 48 patients (group IIb) did not respond to gold and developed gold induced toxic reactions, including thrombocytopenia or proteinuria, or both. HLA-D region antigens were defined by serological and molecular (Southern blot analysis and oligonucleotide typing) techniques. The results show that DR4 was significantly increased in all three groups of patients. The prevalence of DR1, or DR1 in DR4 negative patients, and DR3 and DR4 associated DQw7 specificities, however, showed differences in these three groups of patients. The prevalence of DR1 and of DR1 in DR4 negative patients was increased only in patients with mild (group I) RA, but not in patients with severe (groups IIa and IIb) disease. On the other hand, the prevalence of DR4 associated DQw7 was significantly increased in patients with severe disease, but not in patients with mild RA. In addition, DR3 was significantly increased only in patients with severe disease who developed gold induced toxic reactions (group IIb). These data suggest that the HLA-D region genes which cause susceptibility to mild RA may be different from those causing susceptibility to severe RA. The results suggest that both DR and DQ (A, B) genes may be important in conferring susceptibility to RA: DR in mild disease and DQ in severe RA. Images PMID:1371662

  10. RCE-DR, a novel process for coated conductor fabrication with high performance

    NASA Astrophysics Data System (ADS)

    Lee, Jae-Hun; Lee, Hunju; Lee, Jung-Woo; Choi, Soon-Mi; Yoo, Sang-Im; Moon, Seung-Hyun

    2014-04-01

    We report in detail on SuNAM’s reactive co-evaporation by deposition and reaction (RCE-DR) process. We have successfully fabricated a high performance GdBCO coated conductor (CC) with high throughput by the RCE-DR process, that consists of two steps for the deposition of elemental metal oxides and the conversion of cation oxides into the GdBCO superconducting phase. Constituting metals such as Gd, Ba and Cu were first deposited on LaMnO3 (LMO)-buffered IBAD-MgO templates at low temperatures and low pressures followed by a high temperature treatment step under high oxygen partial pressure for fast phase conversion. GdBCO CCs fabricated by RCE-DR showed excellent transport properties such as a critical current of 794 A cm-1 width at 77 K in self-field. With the RCE-DR process, we have achieved an overall processing speed of more than 120 m h-1 (in terms of a real process linear tape speed equivalent). SuNAM’s RCE-DR technique showed great potential as the highest throughput fabrication process compared with other methods developed previously for second generation high temperature superconducting wires, meeting the current and future need of industry in terms of price and production speed.

  11. A portrait of the extreme solar system object 2012 DR30

    NASA Astrophysics Data System (ADS)

    Kiss, Cs.; Szabó, Gy.; Horner, J.; Conn, B. C.; Müller, T. G.; Vilenius, E.; Sárneczky, K.; Kiss, L. L.; Bannister, M.; Bayliss, D.; Pál, A.; Góbi, S.; Verebélyi, E.; Lellouch, E.; Santos-Sanz, P.; Ortiz, J. L.; Duffard, R.; Morales, N.

    2013-07-01

    2012 DR30 is a recently discovered solar system object on a unique orbit, with a high eccentricity of 0.9867, a perihelion distance of 14.54 AU, and a semi-major axis of 1109 AU, in this respect outscoring the vast majority of trans-Neptunian objects (TNOs). We performed Herschel/PACS and optical photometry to uncover the sizeand albedo of 2012 DR30, together with its thermal and surface properties. The body is 185 km in diameter and has a relatively low V-band geometric albedo of ~8%. Although the colours of the object indicate that 2012 DR30 is an RI taxonomy class TNO or Centaur, we detected an absorption feature in the Z-band that is uncommon among these bodies. A dynamical analysis of the target's orbit shows that 2012 DR30 moves on a relatively unstable orbit and was most likely only recently placed on its current orbit from the most distant and still highly unexplored regions of the solar system. If categorised on dynamical grounds 2012 DR30 is the largest Damocloid and/or high inclination Centaur observed so far. Herschel is an ESA space observatory with science instruments provided by European-led Principal Investigator consortia and with important participation from NASA.Appendices are available in electronic form at http://www.aanda.org

  12. Dr. Walter C. McCrone--his contributions to environmental microscopy.

    PubMed

    Kubic, Thomas A

    2004-03-01

    This paper briefly highlights Dr. McCrone's contributions to the recently emerging field of forensic environmental microscopy. Few, if any, criminalists are not familiar with Dr. Walter C. McCrone's voluminous contributions to the field of forensic microscopy and the analyses of micro and ultra micro transfer (trace) evidence. Dr. McCrone was renowned for his life long efforts in promoting the application of the Polarized Light Microscope (PLM) to problem solving. It is therefore not surprising that Dr. McCrone would also apply his analytical and deductive skills employing the PLM to problems in environmental analysis. He is well known for his many publications dealing with the analysis of asbestos and asbestos like materials by PLM. His philosophy of presenting intense professional training courses stressing the practical applications of the PLM carried over to a series of courses offered to students requiring education in other areas of microscopical analysis. Through McCrone Research Institute, Dr. McCrone can be said to have been responsible for the training of a large majority of microscopists who literally analyzed tens of millions of samples. These analyses were performed utilizing methodologies developed predominately by him and adopted by regulatory agencies in the United States and abroad. The methods he fostered are a major part of the arsenal of microscopical techniques employed by forensic environmental microscopists in their efforts to identify a manufacturer of an insulation product for the purpose of litigation. PMID:15027546

  13. [Dr. Avni Mahmud and the teaching of mental disease in Turkey].

    PubMed

    Er, H

    2001-01-01

    Mental illness and insanity, as distinct from other departments of medicine occupy a special place with their mental aspect and their effect on the conscious consequent, treatment methods before and during middle ages were mainly based on superstition. Here in Turkey, a modern clinic of mental illness and neuropathy was put into the first by Dr. Mongeri. Dr. Avni Mahmud graduated from civilian medical school in 1880 and in 1882 he started as a physician at Toptaşi Asylum. His father Mahund Efendi, was an army physician. Dr. Avni Mahmud became the director of Toptaşi Asylum in 1909 until his death. Dr. Avni Mahmud, who had no special training on mental illness acquired his knowledge and experience here; studying basic works on this subject, he wrote a book titled Muhtasar Emraz-i Akliye, which is thought to be the first of its kind. Dr. Avni Mahmud spent all his effort, with limited means, to make Toptaşi Asylum an orderly and good hospital in his time.

  14. 50th anniversary of the discovery of ibuprofen: an interview with Dr Stewart Adams.

    PubMed

    Halford, Gayle M; Lordkipanidzé, Marie; Watson, Steve P

    2012-01-01

    2011 marks the 50th anniversary of the discovery of ibuprofen. This article is a focus on the personal reflections and career of Dr Stewart Adams OBE, the scientist whose research lead to the discovery of the cyclooxygenase inhibitor. When Dr Adams discovered ibuprofen, he was working as a pharmacologist in the Research Department for the Boots Pure Drug Company Ltd. Dr Adams was assigned to work on rheumatoid arthritis (RA) and chose in 1953 to search for a drug that would be effective in RA but would not be a corticosteroid. He was one of the first workers in this field that later became known as NSAIDs (Non-Steroidal Anti Inflammatory Drugs). In 1961, Dr Adams with John Nicholson, the organic chemist, filed a patent for the compound 2-(4-isobutylphenyl) propionic acid, later to become one of the most successful NSAIDs in the modern world, ibuprofen. In this article, Dr Adams gives his modest insight into the early stages and initial observations which led to this world-wide success.

  15. Serologic and nucleotide sequencing analyses of a novel DR52-associated DRB1 allele with the DR 'NJ25' specificity, designated DRB1*1307.

    PubMed

    Kaneshige, T; Hashimoto, M; Matsumoto, Y; Kinoshita, T; Hirasawa, T; Uchida, K; Inoko, H

    1994-10-01

    A novel DR52-associated DRB1* allele, designated DRB1*1307, was encountered in the course of our HLA-DRB1 genotyping study in a Japanese population by PCR-RFLP. Comparison of the nucleotide sequence of its second exon with those of the other known DRB1 alleles revealed that DRB1*1307 was most similar to DRB1*1101, differing by two amino acid substitutions. From a family study, DRB1*1307 was found to segregate with a haplotype of DRB3*0202-DQA1*0501-DQB1*0301, which was also observed with DRB1*1101 in a Japanese population. DRB1*1307 was recognized in three of 652 healthy Japanese controls (gene frequency: 0.24%) with the same DR-DQ haplotype, indicating that DRB1*1307 arose from DRB1*1101 by a gene conversionlike event(s) and/or point mutations. Further, it was also observed that this allele had a strong linkage disequilibrium with HLA-B70 (p < 0.001). This new DRB1*1307 allele was serologically defined as DR 'NJ25,' and it gave an almost identical serologic pattern to DRB1*1406. On sequence comparison, however, no unique amino acid residues conserved in DRB1*1406 and DRB1*1307 but absent in all the other DRB1 alleles could be found, indicating that two amino acid changes at positions 47 and 58 abolished the reactivity against the DR11 antisera.

  16. Cisplatin containing chemotherapy influences HLA-DR expression on monocytes from cancer patients.

    PubMed

    Novellino, P S; Trejo, Y G; Beviacqua, M; Bordenave, R H; Rumi, L S

    1999-12-01

    The effect of cisplatin-containing chemotherapy regimen was evaluated on the expression of HLA-DR antigen in peripheral blood monocytes from patients with lung (LCP) and colorectal (CCP) cancer. Chemotherapeutic schedules employed in patients were etoposide and cisplatin for LCP and 5-fluorouracil and cisplatin for CCP. The results obtained showed a diminished percentage of monocytes expressing HLA-DR antigen in LCP (52.4 +/- 2.6, p < 0.004) and CCP (50.1 +/- 2.1, p < 0.001) respectively versus healthy donors (71.0 +/- 1.1%), and that their values increased during chemotherapy, raising them up to control level after the second cycle of treatment, independently of the course of the cancer growth. We conclude that both modalities of treatment allowed an increase of monocytes expressing HLA-DR antigen, suggesting that this effect may be due to cisplatin action. PMID:10746974

  17. Collected Papers in Structural Mechanics Honoring Dr. James H. Starnes, Jr.

    NASA Technical Reports Server (NTRS)

    Knight, Norman F., Jr. (Compiler); Nemeth, Michael P. (Compiler); Malone, John B. (Compiler)

    2006-01-01

    This special publication contains a collection of structural mechanics papers honoring Dr. James H. Starnes, Jr. presented at the 46th AIAA/ASME/ASCE/AHS/ASC Structures, Structural Dynamics, and Materials Conference held in Austin, Texas, April 18-21, 2005. Contributors to this publication represent a small number of those influenced by Dr. Starnes' technical leadership, his technical prowess and diversity, and his technical breath and depth in engineering mechanics. These papers cover some of the research areas Dr. Starnes investigated, which included buckling, postbuckling, and collapse of structures; composite structural mechanics, residual strength and damage tolerance of metallic and composite structures; and aircraft structural design, certification and verification. He actively pursued technical understanding and clarity, championed technical excellence, and modeled humility and perseverance.

  18. VizieR Online Data Catalog: PACS Evolutionary Probe (PEP-DR1) catalogs (Lutz+, 2011)

    NASA Astrophysics Data System (ADS)

    Lutz, D.; Poglitsch, A.; Altieri, B.; Andreani, P.; Aussel, H.; Berta, S.; Bongiovanni, A.; Brisbin, D.; Cava, A.; Cepa, J.; Cimatti, A.; Daddi, E.; Dominguez-Sanchez, H.; Elbaz, D.; Foerster Schreiber, N. M.; Genzel, R.; Grazian, A.; Gruppioni, C.; Harwit, M.; Le Floc'h, E.; Magdis, G.; Magnelli, B.; Maiolino, R.; Nordon, R.; Perez Garcia, A. M.; Popesso, P.; Pozzi, F.; Riguccini, L.; Rodighiero, G.; Saintonge, A.; Sanchez Portal, M.; Santini, P.; Shao, L.; Sturm, E.; Tacconi, L. J.; Valtchanov, I.; Wetzstein, M.; Wieprecht, E.

    2013-11-01

    PACS catalogs built by the PEP team, with key contributions by Stefano Berta, Benjamin Magnelli, Paola Popesso, Dieter Lutz, Francesca Pozzi, Bruno Altieri, Herve Aussel, Hoseong Hwang, Emeric Le Floc'h, Georgios Magdis, Raanan Nordon, Albrecht Poglitsch, Laurie Riguccini, Amelie Saintonge, Li Shao. For more details, please refer to Lutz et al. (2011A&A...532A..90L) and to the PDF documentation associated to the release. Data and catalogs can be retrieved from the web page http://www.mpe.mpg.de/ir/Research/PEP/publicdatareleases.php See the PDF documentation associated to the PEP DR1 release, http://www.mpe.mpg.de/resources/PEP/DR1tarballs/readmePEP_global.pdf and http://www.mpe.mpg.de/resources/PEP/DR1tarballs/readmePEP_SPIRE.pdf for more details. (69 data files).

  19. BEopt-CA (Ex): A Tool for Optimal Integration of EE, DR and PV in Existing California Homes

    SciTech Connect

    Christensen, Craig; Horowitz, Scott; Maguire, Jeff; Velasco, Paulo Tabrares; Springer, David; Coates, Peter; Bell, Christy; Price, Snuller; Sreedharan, Priya; Pickrell, Katie

    2014-04-01

    This project targeted the development of a software tool, BEopt-CA (Ex) (Building Energy Optimization Tool for California Existing Homes), that aims to facilitate balanced integration of energy efficiency (EE), demand response (DR), and photovoltaics (PV) in the residential retrofit1 market. The intent is to provide utility program managers and contractors in the EE/DR/PV marketplace with a means of balancing the integration of EE, DR, and PV

  20. Association between risk for pre-eclampsia and HLA DR4

    SciTech Connect

    Not Available

    1990-03-17

    Dr. Kilpatrick and colleagues report results of a family study showing an association between HLA DR4 and mild and proteinuric pre-eclampsia in a British (Edinburgh) maternal population. Among 76 parous sisters of women with protein uric pre-eclampsia, they found that sisters with pregnancy-induced hypertension (pre-eclampsia with or without proteinuria) had a higher frequency of HLA DR4 antigen than did normotensive sisters. In addition, they cited unpublished findings in which they found a higher frequency of HLA DR4 antigen in a large sample of pre-eclamptic women and their babies than in appropriate controls. The authors have completed a study of HLA antigens and pregnancy outcome among a coherent of 715 black (50.9%) and white (49.1%) primigravida who were delivered at a medical center in southern USA. HLA DR typing was done by the one-color fluorescence technique with reagents. On the basis of standard criteria for diagnosis of pre-eclampsia and eclampsia, 6.9 of the cohort had mild non-proteinuric pre-eclampsia, 8.8% had pregnancy-induced hypertension, and 9.5% had combined pre-eclampsia and eclampsia. Whereas black women had higher rates than white women in all three clinical categories (eg, pregnancy-induced hypertension 10.7% vs 6.8%, respectively), differences were not significant and frequencies of HLA DR4 antigen were higher among normotensives in both races (results not shown). They therefore pooled the two racial groups for analyses.

  1. Polyhydroxyalkanoate (PHA) production using waste vegetable oil by Pseudomonas sp. strain DR2.

    PubMed

    Song, Jin Hwan; Jeon, Che Ok; Choi, Mun Hwan; Yoon, Sung Chul; Park, Woojun

    2008-08-01

    To produce polyhydroxyalkanoate (PHA) from inexpensive substrates by bacteria, vegetable-oil-degrading bacteria were isolated from a rice field using enrichment cultivation. The isolated Pseudomonas sp. strain DR2 showed clear orange or red spots of accumulated PHA granules when grown on phosphate and nitrogen limited medium containing vegetable oil as the sole carbon source and stained with Nile blue A. Up to 37.34% (w/w) of intracellular PHA was produced from corn oil, which consisted of three major 3-hydroxyalkanoates; octanoic (C8:0, 37.75% of the total 3-hydroxyalkanoate content of PHA), decanoic (C10:0, 36.74%), and dodecanoic (C12:0, 11.36%). Pseudomonas sp. strain DR2 accumulated up to 23.52% (w/w) of PHAMCL from waste vegetable oil. The proportion of 3- hydroxyalkanoate of the waste vegetable-oil-derived PHA [hexanoic (5.86%), octanoic (45.67%), decanoic (34.88%), tetradecanoic (8.35%), and hexadecanoic (5.24%)] showed a composition ratio different from that of the corn-oil-derived PHA. Strain DR2 used three major fatty acids in the same ratio, and linoleic acid was the major source of PHA production. Interestingly, the production of PHA in Pseudomonas sp. strain DR2 could not occur in either acetate- or butyrate-amended media. Pseudomonas sp. strain DR2 accumulated a greater amount of PHA than other well-studied strains (Chromobacterium violaceum and Ralstonia eutropha H16) when grown on vegetable oil. The data showed that Pseudomonas sp. strain DR2 was capable of producing PHA from waste vegetable oil.

  2. [Study of anti-DR antibodies in sterility and infertility (author's transl)].

    PubMed

    Balasch, J; Vanrell, J A; González-Merlo, J; Ercilla, M G; Vives, J; Castillo, R

    1980-01-01

    The presence of anti-DR antibodies with lymphocyte cytotoxicity test was studied in five groups of patients: 50 males with no history of blood transfusions who comprised the control group, 44 contraceptive-using women, 55 pregnant women, 41 primary sterile and 47 infertile patients. The high and similar degree of sensitization found in both pregnant and sterile patients lead us to the conclusion that anti-DR antibodies are not a cause of sterility and that spermatozoa are highly immunogenic. The biological significance of the antibodies is discussed.

  3. Genetic engineering of a mouse: Dr. Frank Ruddle and somatic cell genetics.

    PubMed

    Jones, Dennis

    2011-06-01

    Genetic engineering is the process of modifying an organism's genetic composition by adding foreign genes to produce desired traits or evaluate function. Dr. Jon W. Gordon and Sterling Professor Emeritus at Yale Dr. Frank H. Ruddle were pioneers in mammalian gene transfer research. Their research resulted in production of the first transgenic animals, which contained foreign DNA that was passed on to offspring. Transgenic mice have revolutionized biology, medicine, and biotechnology in the 21st century. In brief, this review revisits their creation of transgenic mice and discusses a few evolving applications of their transgenic technology used in biomedical research.

  4. Doppler transcranien au cours de la drépanocytose chez l'enfant Malagasy

    PubMed Central

    Herinirina, Nicolas Fanantenana; Rajaonarison, Lova Hasina Ny Ony Narindra; Herijoelison, Andry Roussel; Rakoto, Olivat Aimée Alson; Ahmad, Ahmad

    2016-01-01

    Introduction Le doppler transcrânien est un outil efficace permettant de dépister les enfants drépanocytaires à risque d'AVC. Méthodes Nous avons réalisé une étude descriptive transversale sur des enfants Malagasy âgés entre 24 mois et 15 ans (groupe 1: 57 drépanocytaires, groupe 2: 43 témoins) afin d’évaluer le profil vélocimétrique des artères cérébrales chez les drépanocytaires. Un examen Doppler transcrânien a été réalisé avec étude des flux sanguins cérébraux chez les enfants des deux groupes. Résultats Pour les sujets drépanocytaires, la vitesse moyenne (VM) de l'artère cérébrale moyenne était de 100,9 ± 26,8 cm/s, l'indice de pulsatilité (IP) de 0,73 ± 0,20, la différence entre les artères cérébrales moyennes droite et gauche (ACMr) de 19,8 ± 21,5 cm/s, le rapport des vitesses de l'artère cérébrale antérieure/artère cérébrale moyenne (ACA/ACM) de 0,7 ± 0,2. Pour les enfants non drépanocytaires, VM: 80,6 ± 19,3 cm/s, IP: 0,79 ± 0,14, ACMr: 17 ± 20,1 cm/s, ACA/ACM: 0,8 ± 0,2. La vélocité des enfants drépanocytaires était supérieure au groupe contrôle. Les vitesses ont été corrélées avec le taux d'hémoglobine et l’âge et non pas avec le sexe et le volume globulaire moyen. Conclusion Les vitesses circulatoires cérébrales sont élevées chez les drépanocytaires que les enfants non drépanocytaires et sont influencées par le taux d'hémoglobine et l’âge. PMID:27516829

  5. Genetic engineering of a mouse: Dr. Frank Ruddle and somatic cell genetics.

    PubMed

    Jones, Dennis

    2011-06-01

    Genetic engineering is the process of modifying an organism's genetic composition by adding foreign genes to produce desired traits or evaluate function. Dr. Jon W. Gordon and Sterling Professor Emeritus at Yale Dr. Frank H. Ruddle were pioneers in mammalian gene transfer research. Their research resulted in production of the first transgenic animals, which contained foreign DNA that was passed on to offspring. Transgenic mice have revolutionized biology, medicine, and biotechnology in the 21st century. In brief, this review revisits their creation of transgenic mice and discusses a few evolving applications of their transgenic technology used in biomedical research. PMID:21698043

  6. The medical ethics of the 'father of gynaecology', Dr J Marion Sims.

    PubMed Central

    Ojanuga, D

    1993-01-01

    Vesico-vaginal fistula (VVF) was a common ailment among American women in the 19th century. Prior to that time, no successful surgery had been developed for the cure of this condition until Dr J Marion Sims perfected a successful surgical technique in 1849. Dr Sims used female slaves as research subjects over a four-year period of experimentation (1845-1849). This paper discusses the controversy surrounding his use of powerless women and whether his actions were acceptable during that historical period. PMID:8459435

  7. Dr. Tom Chalmers, 1917-1995: the trials of a randomizer

    PubMed Central

    Maclure, Malcolm

    1996-01-01

    Dr. Thomas Chalmers, an American physician who played a pivotal role in the scientific development of the randomized control trial and meta-analysis, died late last year. Shortly before Chalmers' death, Dr. Malcolm Maclure of the British Columbia Ministry of Health conducted a wideranging interview with him about his life and the past and future of clinical trials and evidence-based medicine. The first part is published below; the second part will appear in the Oct. 1 issue of CMAJ. Imagesp758-a PMID:8823220

  8. Preparation and spectral characterization of polymeric nanocapsules containing DR1 organic dye

    NASA Astrophysics Data System (ADS)

    Sharifimehr, Mohammad Reza; Ghanbari, Khadijeh; Ayoubi, Kazem; Mohajerani, Ezedin

    2015-07-01

    In order to provide necessary degree of freedom for organic dye molecules in optical applications and also for safety improvement, water insoluble Disperse Red 1 (DR1) dye molecules were placed inside the polymeric nanocapsules along with suitable surfactants and using controlled phase-separation method. TEM images were used to investigate the morphology of prepared nanocapsules. Total dye concentration for a solution consist of obtained polymeric nanocapsules was determined using decomposition of nanocapsules and a reference absorption spectrum. Absorption spectrum of a solution containing DR1 and dichloromethane was also compared with prepared nanocapsules at the same dye concentration, thereby a red-shift in absorption spectrum was detected.

  9. MTB-DR-RIF 9G test: Detection and discrimination of tuberculosis and multi-drug resistant tuberculosis strains.

    PubMed

    Song, Keum-Soo; Nimse, Satish Balasaheb; Cho, Nam Hoon; Sung, Nackmoon; Kim, Hee-Jin; Yang, Jeongseong; Kim, Taisun

    2015-12-01

    This report describes the evaluation of the novel MTB-DR-RIF 9G test for the accurate detection and discrimination of Mycobacterium tuberculosis (MTB) and rifampicin-resistant M. tuberculosis (MTB-DR-RIF) in the clinical samples. The procedure included the amplification of a nucleotide fragment of the rpoB gene of the MTB and MTB-DR-RIF strains and their hybridization with the immobilized probes. The MTB-DR-RIF 9G test was evaluated for its ability to detect and discriminate MTB and MTB-DR-RIF strains in 113 known clinical samples. The accuracy of the MTB-DR-RIF 9G test was determined by comparing its results with sequencing analysis and drug susceptibility testing. The sensitivity and specificity of the MTB-DR-RIF 9G test at 95% confidence interval were found to be 95.4% (89.5-98.5) and 100% (69.2-100), respectively. The positive predictive value and negative predictive value of the MTB-DR-RIF 9G test at 95% confidence interval were found to be 100% (85.0-95.9) and 66.7% (38.4-88.18), respectively. Sequencing analysis of all samples indicated that the mutations present in the regions identified with the MTB-DR-RIF 9G assay can be detected accurately.

  10. Human radiation studies: Remembering the early years. Oral history of Dr. George Voelz, M.D., November 29, 1994

    SciTech Connect

    1995-05-01

    Dr. George Voelz was interviewed by representatives of the US DOE Office of Human Radiation Experiments (OHRE). This oral history covers Dr. Voelz`s research on Manhattan Engineering District plutonium workers, the acute and long term effects of radiation, his inhalation studies, and his activities at the 1961 INL reactor accident (SL-1 Reactor). After a brief biographical sketch, Dr. Voelz his remembrances on tissue studies of plutonium workers, the plutonium injection studies of 1945-1946, the controlled environmental radioiodine tests of 1963-1968, and tracer studies with human volunteers at Los Alamos. Dr. Voelz states his opinions concerning misconceptions about the Los Alamos Human Radiation Experiments.

  11. [Dr Leonor Michaelis and early days of Hokkaido University School of Medicine; episodes among three medical researchers in the roaring twenties].

    PubMed

    Watanabe, Makoto; Koyama, Akio; Saito, Takeshi; Terasawa, Kouich; Fujita, Hiroyoshi; Saito, Kazuo

    2011-08-01

    Little has been known about the personal history of Dr. Takaichi Mohri (Nakashima), the first professor of department of hygiene at Hokkaido University School of Medicine. We, therefore, have been inquiring academic backgrounds of Dr. Mohri for two decades. These inquiries show interesting episodes between Dr. Leonor Michaelis, one of the biggest names in enzymologists, and early days of this Medical School. In this article, we describe that at least two professors, Drs. Takaichi Mohri and Kaoru Ohguro, were in good acquaintances with Dr. Michaelis as follows; 1) the latter half of 1921, Dr. Ohguro visited a laboratory of Dr. Michaelis in Berlin, 2) from November 1922 to June 1923, Dr. Michaelis in Nagoya collaborated with Dr. Mohri in Sapporo, 3) Dr. Michaelis in Nagoya visited Dr. Ohguro's house and office in Sapporo at March 1925, and 4) at the same occasion, Dr. Michaelis made his lecture on biochemistry in Hokkaido University School of Medicine. Since Drs. Ohguro and Mohri were classmates of the University of Tokyo Faculty of Medicine, Dr. Ohguro could introduce Dr. Michaelis to Dr. Mohri who used to be a graduate student in department of biochemistry. As a result of relationships, Drs. Michaelis and Mohri published a paper entitled "Eine weitere Methode zur Bestimmung des isoelektrischen Punktes von Eiweisskoerpern und ihre Anwendung auf die Serumalbumine verschiedener Tiere" in Biochemische Zeitschrift, which was a part of Dr. Mohri's Ph.D. thesis. PMID:21877585

  12. DNA restriction fragment length polymorphism of HLA-DR2 haplotypes in normal individuals and in patients with rheumatoid arthritis.

    PubMed Central

    Singal, D P; Reid, B; Green, D; Bensen, W G; D'Souza, M

    1990-01-01

    A strong association between HLA-DR4 and rheumatoid arthritis (RA) has been found in a number of populations. In contrast, the incidence of DR2 is decreased in patients with RA, suggesting that this specificity may confer some protection against the disease. A number of subtypes of DR2 have been defined by serology, by responses in mixed lymphocyte culture reaction, and, more recently, by restriction fragment length polymorphism. These subtypes of DR2 are in linkage disequilibrium with different subspecificities of DQw1. It is thus likely that the distribution of these subtypic DR,DQ haplotypes in DR2 positive patients with RA may be important in understanding the genetic basis of susceptibility/resistance to RA. In this paper a study of the subtypes of DR2,DQw1 haplotypes in 18 patients with RA, who required sodium aurothiomalate as a disease remitting drug, and unrelated healthy individuals is reported. Three subtypes of DR2 haplotypes, DRw15 (Dw2),DQw1.2(DQw6), DRw15(Dw12),DQw1.12(DQw6), and DRw16(Dw21),DQw1, AZH (DQw5), were analysed with a cDNA probe for the DQ beta gene. The data show that DR2 positive patients with RA carried either the DRw15(Dw2),DQw6 or DRw15(Dw12),DQw6 haplotype. No patient with RA was positive for the DRw16(Dw21),DQw5 subspecificity. In contrast, six of 29 (21%) normal healthy DR2,DQw1 positive individuals carried the DRw16(Dw21),DQw5 haplotype. These data together with earlier results on the distribution of the DR4,DQw7 haplotype in patients with RA support the hypothesis that DQB1 chain polymorphism may be important in determining susceptibility to severe RA. Images PMID:1969727

  13. Dr. Bowdler's Legacy: A History of Expurgated Books in England and America.

    ERIC Educational Resources Information Center

    Perrin, Noel

    This history of expurgation of English and American literature from 1724 until the 1960's focuses on the influence of changing taste upon literature, especially the changing standards of what constitutes decency. Discussed are (1) expurgations of literary works in the 18th century and the causes of bowdlerism; (2) Dr. Bowdler, his sister (the true…

  14. HUCKLEBERRY FINN. DR. JEKYLL AND MR. HYDE. SHORT STORIES. LITERATURE CURRICULUM IV, TEACHER VERSION.

    ERIC Educational Resources Information Center

    KITZHABER, ALBERT R.

    A CURRICULUM GUIDE FOR THE TEACHING OF "HUCKLEBERRY FINN,""DR. JEKYLL AND MR. HYDE," AND FOUR SHORT STORIES WAS PRESENTED. THE SHORT STORIES WERE (1) "THE APPLE TREE" BY JOHN GALSWORTHY, (2) "THE COUNTRY OF THE BLIND" BY H.G. WELLS, (3) "A DOUBLE-DYED DECEIVER" BY O. HENRY, AND (4) "A MYSTERY OF HEROISM" BY STEPHEN CRANE. THE GUIDE PROVIDED…

  15. HUCKLEBERRY FINN. DR. JEKYLL AND MR. HYDE. SHORT STORIES. LITERATURE CURRICULUM IV, STUDENT VERSION.

    ERIC Educational Resources Information Center

    KITZHABER, ALBERT R.

    A STUDENT'S CURRICULUM GUIDE FOR THE STUDY OF "HUCKLEBERRY FINN,""DR. JEKYLL AND MR. HYDE," AND THREE SHORT STORIES WAS PRESENTED. THE SHORT STORIES INCLUDED WERE (1) "THE COUNTRY OF THE BLIND" BY H.G. WELLS (COMPLETE TEXT), (2) "A DOUBLE-DYED DECEIVER" BY O. HENRY, AND (3) "A MYSTERY OF HEROISM" BY STEPHEN CRANE (COMPLETE TEXT). STUDY QUESTIONS,…

  16. State Environmental Policy Act (SEPA) Checklist for the 105-DR Large Sodium Fire Facility Closure Plan

    SciTech Connect

    Not Available

    1990-09-01

    The Hanford Site, located northwest of the city of Richland, Washington, houses reactors, chemical-separation systems, and related facilities used for the production of special nuclear materials, as well as for activities associated with nuclear energy development. The 105-DR Large Sodium Fire Facility (LSFF), which was in operation from about 1972 to 1986, was a research laboratory that occupied the former ventilation supply room on the southwest side of the 105-DR Reactor facility. The LSFF was established to provide means of investigating fire and safety aspects associated with large sodium or other metal alkali fires in the liquid metal fast breeder reactor (LMFBR) facilities. The 105-DR Reactor facility was designed and built in the 1950's and is located in the 100-D Area of the Hanford Site. The building housed the DR defense reactor, which was shut down in 1964. The LSFF is subject to the regulatory requirements for the storage and treatment of dangerous wastes. Clean closure is the proposed method of closure for the LSFF. Closure will be conducted pursuant to the requirements of the Washington Administrative Code (WAC) 173-303-610 (Ecology 1989). This closure plan presents a description of the facility, the history of wastes managed, and the procedures that will be followed to close the LSFF as an Alkali Metal Treatment Facility. No future use of the LSFF is expected.

  17. Dr. Wernher Von Braun on Tour With U.S. congressman Armistead Seldon

    NASA Technical Reports Server (NTRS)

    1999-01-01

    U.S. representative Armistead Seldon (D.-Al) tries on an astronaut maneuvering unit mockup during a tour of the Saturn I workshop at the Marshall Space Flight center. Explaining the unit and the workshop to Representative Seldon is Dr. Wernher Von Braun, director of the Marshall Center.

  18. Dr. Wernher Von Braun at the Marshall Space Flight Center's neutral buoyancy simulator.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun, Marshall Space Flight Center director, points and asks a question about the operation of the center's neutral buoyancy facility in the Manufacturing Engineering Laboratory. The facility was used to test and evaluate hardware and operations hat were planned for Apollo applications program flights.

  19. If Dr. King Were a Principal: Building the "Beloved Community" in Schools

    ERIC Educational Resources Information Center

    Hillis, Michael; Woolworth, Stephen

    2008-01-01

    In this article, the authors offer a more humanistic vision of educational community, one that is substantive in content yet flexible in its application to the diverse contexts in which American schooling occurs. In doing so, the authors turn specifically to the nonviolent philosophy of Dr. Martin Luther King, Jr. and consider what a school…

  20. Dr. Anna Julia Cooper, 1858-1964: Teacher, Scholar, and Timeless Womanist

    ERIC Educational Resources Information Center

    Giles, Mark S.

    2006-01-01

    The study examines the various accomplishments and achievements of Dr. Anna Julia Cooper, a social activist-educator, scholar and an early model for African-American feminist theory. Cooper was a great public intellectual and teacher, as she highly attacked the prevalence of racism, sexism and poverty through her writings and by working with…

  1. Multiband photometric follow-up of ASASSN-13aw (SN 2013dr)

    NASA Astrophysics Data System (ADS)

    Wyrzykowski, L.; Campbell, H. C.; Koposov, S.; Ulaczyk, K.; Damljanovic, G.; Vince, O.; Pavlovic, R.; Cvetkovic, Z.; Stojanovic, M.; Kolb, U.; Bochinski, J.; Burwitz, V.; Haswell, C.; Rodriguez, J.; Harding, J.; Busuttil, R.

    2013-08-01

    We report the result of an extensive photometric follow-up of ASASSN-13aw (ATEL#5183) aka SN 2013dr, classified as type Ia supernova (Tomasella et al., CBAT TOCP for PSN J17193026+4742046). The telescopes involved in the follow-up operated in the preparatory mode for the forthcoming Gaia Science Ale$ follow-up network.

  2. Photographer: Digital Telepresence: Dr Murial Ross's Virtual Reality Application for Neuroscience

    NASA Technical Reports Server (NTRS)

    1995-01-01

    Photographer: Digital Telepresence: Dr Murial Ross's Virtual Reality Application for Neuroscience Research Biocomputation. To study human disorders of balance and space motion sickness. Shown here is a 3D reconstruction of a nerve ending in inner ear, nature's wiring of balance organs.

  3. Has the Dream Been Fulfilled? Dr. Martin Luther King, Jr. & President Barack Hussein Obama

    ERIC Educational Resources Information Center

    Robinson, Nichelle Boyd; Moore, Virginia J.; Williams-Black, Thea H.

    2015-01-01

    Equality for all was the dream of Dr. Martin Luther King, Jr. and he knowingly laid the foundation for and inspired the first African-American President of the United States of America, Barack Hussein Obama, who also had the dream of "Change" for America. These men exhibited how working together can make dreams become reality. For the…

  4. African American Women Scholars and International Research: Dr. Anna Julia Cooper's Legacy of Study Abroad

    ERIC Educational Resources Information Center

    Evans, Stephanie Y.

    2009-01-01

    EIn this article, the author presents a little-known but detailed history of Black women's tradition of study abroad. Specifically, she situates Dr. Anna Julia Cooper within the landscape of historic African American students who studied in Japan, Germany, Jamaica, England, Italy, Haiti, India, West Africa, and Thailand, in addition to France. The…

  5. Citizenship Ceremony for Dr. von Braun and German-Born Scientists and Engineers

    NASA Technical Reports Server (NTRS)

    1955-01-01

    In a swearing-in ceremony held at Huntsville High School, one hundred and three German-born scientists and engineers, along with family members, took the oath of citizenship to become United States citizens. Among those taking the oath was Dr. Wernher von Braun, located in the second row, right side, third from the end.

  6. Why We Do Not Have Ethical Conduct: A Response to Dr. Sternberg

    ERIC Educational Resources Information Center

    Carson, Jamin

    2014-01-01

    In "We Need to Teach for Ethical Conduct," Dr. Robert Sternberg argued that students act unethically because they are unable to transfer principles of ethics into practice. While I agree that this is partially the case, it is also the case that unethical behavior is a result of the prevailing educational-philosophy: radical…

  7. Dr. Clarke vs. the "Ladies": Coeducation and Women's Roles in the 1870's.

    ERIC Educational Resources Information Center

    Seller, Maxine S.

    Negative reaction to the theories forwarded in Dr. Edward H. Clarke's 1873 treatise against coeducation, "Sex in Education or A Fair Chance for the Girls," has been largely neglected. The book appeared at a time when conspicuous numbers of women were extending their activities by campaigning for suffrage; working in factories, schools, and…

  8. Association between human leukocyte antigen-DR and demylinating Guillain-Barré syndrome

    PubMed Central

    Hasan, Zaki N.; Zalzala, Haider H.; Mohammedsalih, Hyam R.; Mahdi, Batool M.; Abid, Laheeb A.; Shakir, Zena N.; Fadhel, Maithem J.

    2014-01-01

    Objective: To find an association between human leukocyte antigen (HLA) class II DRB1, DRB3, DRB4, and DRB5 alleles frequencies in a sample of Iraqi patients with Guillain-Barré syndrome (GBS) and compare with a healthy control group. Methods: We performed a cross-sectional study consisting of 30 Iraqi Arab patients with GBS attending the Neurological Department in the Neuroscience Hospital, Baghdad, Iraq between September 2012 and June 2013. The control group comprised 42 apparently healthy volunteers. Human leukocyte antigen genotyping for HLA DRB1, DRB3, DRB4, and DRB5 was performed using the polymerase chain reaction-sequence-specific primers method. The allele frequencies were compared across both groups. Major histocompatibility complex (MHC)-class II HLA-DR genotyping and serotyping were performed by software analysis. Results: We found increased frequencies of HLA genotype DRB1*03:01 (p=0.0009), DRB1*07:01 (p=0.0015), and DRB4*01:01 (p<0.0001) in patients with GBS compared with healthy controls. The HLA DR6 was increased in the control group (p<0.0001). Conclusions: Our results suggest an association between HLA-DRB1*03:01, DRB1*07:01, DRB4*01:01, and HLA DR3, DR7 and a susceptibility to GBS. PMID:25274590

  9. Expression of MIF and CD74 in leukemic cell lines: correlation to DR expression destiny.

    PubMed

    Georgouli, Mirella; Papadimitriou, Lina; Glymenaki, Maria; Patsaki, Valia; Athanassakis, Irene

    2016-06-01

    Invariant chain (Ii) or CD74 is a non-polymorphic glycoprotein, which apart from its role as a chaperone dedicated to MHCII molecules, is known to be a high-affinity receptor for macrophage migration inhibitory factor (MIF). The present study aimed to define the roles of CD74 and MIF in the immune surveillance escape process. Towards this direction, the cell lines HL-60, Raji, K562 and primary pre-B leukemic cells were examined for expression and secretion of MIF. Flow cytometry analysis detected high levels of MIF and intracellular/membrane CD74 expression in all leukemic cells tested, while MIF secretion was shown to be inversely proportional to intracellular HLA-DR (DR) expression. In the MHCII-negative cells, IFN-γ increased MIF expression and induced its secretion in HL-60 and K562 cells, respectively. In K562 cells, CD74 (Iip33Iip35) was shown to co-precipitate with HLA-DOβ (DOβ), inhibiting thus MIF or DR binding. Induced expression of DOα in K562 (DOα-DOβ+) cells in different transfection combinations decreased MIF expression and secretion, while increasing surface DR expression. Thus, MIF could indeed be part of the antigen presentation process.

  10. Connect the Book. Martin's Big Words: The Life of Dr. Martin Luther King, Jr.

    ERIC Educational Resources Information Center

    Brodie, Carolyn S.

    2005-01-01

    In honor of Martin Luther King, Jr. Day, this month's featured book is "Martin's Big Words: The Life of Dr. Martin Luther King, Jr." The book was written by Doreen Rappaport and illustrated by Bryan Collier (Jump at the Sun, 2001. 40p. ISBN 0786807148). This pictorial biography of the world-renowned civil rights leader has one of the most striking…

  11. The Research of Dr. Joanne Simpson: Fifty Years Investigating Hurricanes, Tropical Clouds and Cloud Systems

    NASA Technical Reports Server (NTRS)

    Tao, W. -K.; Halverson, J.; Adler, R.; Garstang, M.; Houze, R., Jr.; LeMone, M.; Pielke, R., Sr.; Woodley, W.; O'C.Starr, David (Technical Monitor)

    2001-01-01

    This AMS Meteorological Monographs is dedicated to Dr. Joanne Simpson for her many pioneering research efforts in tropical meteorology during her fifty-year career. Dr. Simpson's major areas of scientific research involved the "hot tower" hypothesis and its role in hurricanes, structure and maintenance of trade winds, air-sea interaction, and observations and the mechanism for hurricanes and waterspouts. She was also a pioneer in cloud modeling with the first one-dimensional model and had the first cumulus model on a computer. She also played a major role in planning and leading observational experiments on convective cloud systems. The launch of the Tropical Rainfall Measuring Mission (TRMM) satellite, a joint U.S.-Japan project, in November of 1997 made it possible for quantitative measurements of tropical rainfall to be obtained on a continuous basis over the entire global tropics. Dr. Simpson was the TRAM Project Scientist from 1986 until its launch in 1997. Her efforts during this crucial period ensured that the mission was both well planned scientifically and well engineered as well as within budget. In this paper, Dr. J. Simpson's nine specific accomplishments during her fifty-year career: (1) hot tower hypothesis, (2) hurricanes, (3) airflow and clouds over heated islands, (4) cloud models, (5) trade winds and their role in cumulus development, (6) air-sea interaction, (7) cloud-cloud interactions and mergers, (8) waterspouts, and (9) TRMM science, will be described and discussed.

  12. MSFC Director Dr. Jerroll W. Littles with President Clinton in Oval office.

    NASA Technical Reports Server (NTRS)

    1997-01-01

    Marshall's eighth Center Director Dr. Jerroll W. Littles (1996-1998) and his wife are pictured with President Bill Clinton in the Oval Office of the White House following the presentation of the Presidential Rank Award for Distinguished Service. Other NASA honorees and their spouses are also pictured.

  13. Advancing the Fundamental Understanding of Fission: 2014 LDRD 20120077DR Review

    SciTech Connect

    White, Morgan C.; Tovesson, Fredrik K.; Sierk, Arnold John

    2014-02-06

    The following slides were presented as part of the LDRD 20120077DR Progress Appraisal Review held Tuesday, February 4, 2014. This is part of an ongoing project assessment the previous of which was documented in LA-UR-13-21182. This presentation documents the progress made against the goals agreed to as part of the 2013 review.

  14. Dr. Mary McLeod Bethune: A Life Devoted to Service

    ERIC Educational Resources Information Center

    Long, Kim Cliett

    2011-01-01

    The purpose of this paper is to explore and analyze the leadership traits of Dr. Mary McLeod Bethune, an African-American woman of history, using the servant leadership theory developed by Robert K. Greenberg and the ten characteristics of servant leadership as conceived by Larry C. Spears. This exploration seeks to identify the significant…

  15. From the Field: Speech Therapy Outcome Measures--Interview with Dr. Pam Enderby

    ERIC Educational Resources Information Center

    Montgomery, Judy K.

    2015-01-01

    This article is an interview with Dr. Pam Enderby--a speech language therapist and professor at the Institute of General Practice and Primary Care at the University of Sheffield, Community Sciences Centre, Northern General Hospital, in the United Kingdom--conducted by Judy Montgomery, Editor in Chief, of "Communication Disorders…

  16. It Really Is All about the Child: An Interview with Dr. Edward Hallowell

    ERIC Educational Resources Information Center

    Peters, Dane L.

    2012-01-01

    In a decade when brain research has helped people understand learning difficulties in children, and people have seen increased media attention on the use of medications to treat attention deficit/hyperactivity disorder (ADHD) in children and adults, Dr. Edward (Ned) Hallowell has worked tirelessly to educate the medical profession, parents,…

  17. [Life and work of Dr. Bozo Pericić (1865-1947), genius of our medicine].

    PubMed

    Perović, Slavko; Sirovica, Stjepan

    2004-01-01

    The paper describes the life and work of on of our most distinguished physicians--Dr Bozo Pericić. Togheter with another young physician Dr Nikola Lalić the Sibenik hospital became a sort of Meca for medical people. Dr Pericić succeded to clarify an unknown disease--so called "Skrljevo disease", paved the path of to the knowledge about achinococcus etc. He published also number of valuable medical articles and books and avarded a number af aknowledgements. One of the biggest was his nomination for membership of the Supreme Haelth Council in Wienna. He contributed e lot to the medical journals, especially to the "Physician's Journal". As person of wide culture, famous linguist and polyglot Dr Pericić published the "Medical dictionary of Croatian and German Language". He lay foundation of the craniology, quite a new branch of arheology at the time. His accounts of travels, reviews on famous writers, translation of Hamlet, etc--are valuable literary works. PMID:15918326

  18. An Interview with Dr. Roach van Allen (Leaders in Reading Research and Instruction).

    ERIC Educational Resources Information Center

    Searfoss, Lyndon; Jerrolds, Bob W.

    1989-01-01

    Presents an interview with Dr. Roach van Allen in which he describes how he became involved in education, who influenced him professionally, his proudest accomplishments (a theoretical model for a language experience program), what he sees as the current problems in reading education, and what he sees in the future. (RS)

  19. Dr William Thornton (1759-1828) a savant of colonial America.

    PubMed

    Schneeberg, Norman G

    2006-08-01

    Dr William Thornton, an Edinburgh-trained physician, practised medicine sporadically in the British West Indies, the location of his birthplace, and in Philadelphia during post-revolutionary Colonial America. He is not well known to medical historians and 21st century physicians and is remembered principally as the amateur architect who designed the Capitol in Washington, DC and the Library Company of Philadelphia.

  20. LITERATURE CURRICULUM IV--TESTS FOR "HUCKLEBERRY FINN" AND "DR. JEKYLL AND MR. HYDE."

    ERIC Educational Resources Information Center

    KITZHABER, ALBERT R.

    THESE TWO TESTS--"HUCKLEBERRY FINN" AND "DR. JEKYLL AND MR. HYDE"--WERE DESIGNED BY THE OREGON CURRICULUM STUDY CENTER FOR A 10TH-GRADE LITERATURE CURRICULUM. THEY ARE INTENDED TO ACCOMPANY CURRICULUM UNITS AVAILABLE AS ED 010 821 AND ED 010 822. (MM)

  1. Algebra Project DR K-12 Cohorts--Demonstration Project: Summative Evaluation Report

    ERIC Educational Resources Information Center

    St. John, Mark

    2014-01-01

    The Algebra Project DR K-12, funded by the National Science Foundation as a Research and Development Project, addressed the challenge of offering significant STEM content for students to ensure public literacy and workforce readiness. The project's primary purpose was to test the feasibility and effectiveness of a model for establishing four-year…

  2. The Role of TL1A and DR3 in Autoimmune and Inflammatory Diseases

    PubMed Central

    Aiba, Yoshihiro; Nakamura, Minoru

    2013-01-01

    TNF-like ligand 1A (TL1A), which binds its cognate receptor DR3 and the decoy receptor DcR3, is an identified member of the TNF superfamily. TL1A exerts pleiotropic effects on cell proliferation, activation, and differentiation of immune cells, including helper T cells and regulatory T cells. TL1A and its two receptors expression is increased in both serum and inflamed tissues in autoimmune diseases such as inflammatory bowel disease (IBD), rheumatoid arthritis (RA), and ankylosing spondylitis (AS). Polymorphisms of the TNFSF15 gene that encodes TL1A are associated with the pathogenesis of irritable bowel syndrome, leprosy, and autoimmune diseases, including IBD, AS, and primary biliary cirrhosis (PBC). In mice, blocking of TL1A-DR3 interaction by either antagonistic antibodies or deletion of the DR3 gene attenuates the severity of multiple autoimmune diseases, whereas sustained TL1A expression on T cells or dendritic cells induces IL-13-dependent small intestinal inflammation. This suggests that modulation of TL1A-DR3 interaction may be a potential therapeutic target in several autoimmune diseases, including IBD, RA, AS, and PBC. PMID:24453414

  3. The role of low-mass star clusters in forming the massive stars in DR 21

    NASA Astrophysics Data System (ADS)

    Rivilla, V. M.; Jiménez-Serra, I.; Martín-Pintado, J.; Sanz-Forcada, J.

    2014-01-01

    We have studied the young low-mass pre-main sequence (PMS) stellar population associated with the massive star-forming region DR 21 by using archival X-ray Chandra observations and by complementing them with existing optical and infrared (IR) surveys. The Chandra observations have revealed for the first time a new highly extincted population of PMS low-mass stars previously missed in observations at other wavelengths. The X-ray population exhibits three main stellar density peaks, coincident with the massive star-forming regions, being the DR 21 core the main peak. The cross-correlated X-ray/IR sample exhibits a radial `Spokes-like' stellar filamentary structure that extends from the DR 21 core towards the northeast. The near-IR data reveal a centrally peaked structure for the extinction, which exhibits its maximum in the DR 21 core and gradually decreases with the distance to the N-S cloud axis and to the cluster centre. We find evidence of a global mass segregation in the full low-mass stellar cluster, and of a stellar age segregation, with the youngest stars still embedded in the N-S cloud, and more evolved stars more spatially distributed. The results are consistent with the scenario where an elongated overall potential well created by the full low-mass stellar cluster funnels gas through filaments feeding stellar formation. Besides the full gravitational well, smaller scale local potential wells created by dense stellar sub-clusters of low-mass stars are privileged in the competition for the gas of the common reservoir, allowing the formation of massive stars. We also discuss the possibility that a stellar collision in the very dense stellar cluster revealed by Chandra in the DR 21 core is the origin of the large-scale and highly energetic outflow arising from this region.

  4. Successful treatment of recalcitrant candidal intertrigo with Dr Michaels® (Fungatinex®) product family.

    PubMed

    Hercogovấ, J; Tirant, M; Bayer, P; Coburn, M; Donnelly, B; Kennedy, T; Gaibor, J; Arora, M; Clews, L; Fioranelli, M; Gianfaldoni, S; Chokoeva, A A; Tchernev, G; Wollina, U; Novotny, F; Roccia, M G; Maximov, G K; França, K; Lotti, T

    2016-01-01

    Candidal intertrigo is an infection of the skin caused by Candida albicans that typically occurs in opposing cutaneous or muco-cutaneous surfaces. Because Candidiasis requires a damaged and moist environment for infection, it typically occurs in areas of friction such as the skin folds of the body. Candidal intertrigo is often difficult to treat and results are often unsatisfactory. In addition, there is a lack of evidence-based literature supporting prevention and treatments for candidal intertrigo. The aim of the study was to evaluate the efficacy of Dr Michaels® (also branded as Fungatinex®) products in the treatment of fungal intertrigo, in 20 women and 2 men with a mean age of 72. Five patients (3 female and 2 male) had type 2 diabetes and 16 (14 female and 2 male) were obese. The patients were treated with Dr Michaels® (Fungatinex®) moisturising bar, topical ointment (twice daily application) and oral herbal formulation, PSC 200 two tablets twice daily with food. After 2 weeks of treatment, the lesions had mostly resolved in all patients with only slight erythema evident. After six weeks of treatment using the moisturising bar, topical ointment and oral herbal formulations from the Dr Michaels® (Fungatinex®) product family, the lesions had totally resolved in 18 patients, while 4 patients had to continue the therapeutic protocol for another 2 weeks. Our results demonstrate that the Dr Michaels® (Fungatinex®) complementary product family is efficacious in the treatment of recalcitrant candidal intertrigo. Furthermore, this study highlights that the Dr Michaels® (Fungatinex®) product family is fast-acting and well tolerated with no serious adverse events reported. These data have important implications for resistant cases of candidal intertrigo where traditional therapies have failed. PMID:27498664

  5. Inhibition of B-Raf/MEK/ERK signaling suppresses DR5 expression and impairs response of cancer cells to DR5-mediated apoptosis and T cell-induced killing.

    PubMed

    Oh, Y-T; Deng, J; Yue, P; Owonikoko, T K; Khuri, F R; Sun, S-Y

    2016-01-28

    Inhibition of B-Raf/MEK/ERK signaling is an effective therapeutic strategy against certain types of cancers such as melanoma and thyroid cancer. While demonstrated to be effective anticancer agents, B-Raf or MEK inhibitors have also been associated with early tumor progression and development of secondary neoplasms. The ligation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) with its receptor, death receptor 5 (DR5), leading to induction of apoptosis, offers a promising anticancer strategy. Importantly, this is also a natural immunosurveillance mechanism against cancer development. We previously demonstrated that activated B-Raf/MEK/ERK signaling positively regulates DR5 expression. Hence, our current work sought to address whether B-Raf/MEK/ERK inhibition and the consequent suppression of DR5 expression impede cancer cell response to DR5 activation-induced apoptosis and activated immune cell-induced killing. We found that both B-Raf (for example, PLX4032) and MEK inhibitors (for example, AZD6244 and PD0325901) effectively inhibited ERK1/2 phosphorylation and reduced DR5 levels in both human thyroid cancer and melanoma cells. Similar to the observed effect of genetic knockdown of the B-Raf gene, pre-treatment of cancer cell lines with either B-Raf or MEK inhibitors attenuated or abolished cellular apoptotic response induced by TRAIL or the DR5 agonistic antibody AMG655 or cell killing by activated T cells. Our findings clearly show that inhibition of B-Raf/MEK/ERK signaling suppresses DR5 expression and impairs DR5 activation-induced apoptosis and T cell-mediated killing of cancer cells. These findings suggest a potential negative impact of B-Raf or MEK inhibition on TRAIL- or DR5-mediated anticancer therapy and on TRAIL/DR5-mediated immune-clearance of cancer cells.

  6. All I Really Need to Know I Learned in Kindergarten: How Dr. Seuss Reinforces Management Concepts and Promotes Community Citizenship

    ERIC Educational Resources Information Center

    Comer, Debra R.; Holbrook, Robert L., Jr.

    2005-01-01

    The authors recommend that management educators add the works of Dr. Seuss to their repertoire of teaching tools. After describing why instructors should use Dr. Seuss's stories to foster understanding of concepts in management and organizational behavior, the authors describe a Seuss-based project at two levels that (a) helps students identify…

  7. Professional Development: What Works? Q&A with Dr. Hilda Borko. REL Mid-Atlantic Teacher Effectiveness Webinar Series

    ERIC Educational Resources Information Center

    Regional Educational Laboratory Mid-Atlantic, 2013

    2013-01-01

    In this webinar, Dr. Hilda Borko, professor, Stanford University Graduate School of Education, presented examples of promising models of professional development, including the Problem-Solving Cycle, Learning and Teaching Geometry, and the use of videos as tools for teacher learning. This Q&A addressed the questions participants had for Dr.…

  8. From the Grass: An Interview with Dr. Krzysztof Pawlowski, Rector of WSB-NLU in Nowy Sacz, Poland.

    ERIC Educational Resources Information Center

    Paradiso, James; Pawlowski, Krzysztof

    This document provides a transcript of an interview with Dr. Krzysztof Pawlowski, founder and president of the Wyzsza Szkola Biznesu (Higher Business School) of National-Louis University (WSB-NLU), the first private higher business school licensed by the Polish Ministry of Education. First, Dr. Pawlowski describes his initial establishment in 1991…

  9. Rational Emotive Behavioural Therapy: The Evolution of a Revolution: Interview With Dr. Debbie Joffe Ellis, Work Partner and Wife of Dr. Albert Ellis, the Creator of REBT.

    PubMed

    Ellis, Debbie Joffe; Rovira, Montse

    2015-02-01

    Recognized as one of the most influential thinkers and psychologists, Albert Ellis PhD (1913-2007) revolutionized Psychology when he created the first cognitive psychotherapy, Rational Emotive Behavioral Therapy. After he passed away, Dr. Debbie Joffe Ellis continues spreading his legacy around the world. Psychologist, lecturer, writer, trainer, she dedicates her life to disseminate REBT and extend it through different statements, from the social to the educational, from the academic to the clinical. In this interview, she goes through her own history and her husband's one, bringing us closer to understanding Albert Ellis as the leading figure in his field, and the oneness they experienced through their professional and personal relationship.

  10. SU-E-T-185: Feasibility Study of Dose Rate Modulated Arc Therapy (DrMAT) for Lung SBRT

    SciTech Connect

    KO, Y; Cho, B; Yi, B; Kwak, J; Song, S; Je, H; Ahn, S; Noh, Y

    2014-06-01

    Purpose: To show the feasibility of clinical application of DrMAT for SBRT in lung cancer patients. DrMAT is a form of dynamic conformal arc therapy where MLC segments and dose rates are controlled through simple field weight optimization. Methods: To show feasibility a new treatment plan was created based on the CT of SBRT lung cancer patients. Static plans with 33 fields are made, which have 11deg in between each field and are acquired rotating gantry angle from 180deg to 188deg in CCW direction, total 352deg is rotated. MLC maintained static aperture for each field. To optimize 33 individual fields, field weight was adjusted accordingly using weight optimization algorithm. Keeping weights and MU of static plan, static MLC aperture was converted to multiple arc segments. Arc plan could be created with the fields in the intervals of 11deg. Static MLC should be converted to arc segment MLC. Dynamic conformal arc therapy plan consists of 33 arc fields, is converted to one dose rate modulated arc therapy (DrMAT) plan. DrMAT plan consists of 166 control points which becomes a single arc plan that changes the shape of MLC for every 2.2deg. The resulting DrMAT plan is not an inverse plan it is a simple form of dynamic conformal arc plan using field weight obtained from static plan. This is compared and evaluated with the VMAT plan. Results: DrMAT and VMAT plans have been compared based on the RTOG1021. Both DrMAT and VMAT plans satisfy 100% irradiation to 95% of PTV and critical organs did not exceed dose limit suggested in RTOG1021. DrMAT plan is almost similar with VMAT plan in Result. Conclusion: Field weight optimization method did not show better Resultcompared to VMAT optimization. However, considering simplicity, DrMAT satisfies the condition in RTOG1021. Therefore clinical application of DrMAT is feasible.

  11. Effects of corticotropin-releasing hormone on proopiomelanocortin derivatives and monocytic HLA-DR expression in patients with septic shock.

    PubMed

    Matejec, Reginald; Kayser, Friederike; Schmal, Frauke; Uhle, Florian; Bödeker, Rolf-Hasso; Maxeiner, Hagen; Kolbe, Julia Anna

    2013-09-01

    Little is known about interactions between immune and neuro-endocrine systems in patients with septic shock. We therefore evaluated whether the corticotropin-releasing hormone (CRH) and/or proopiomelanocortin (POMC) derivatives [ACTH, β-endorphin (β-END), β-lipotropin (β-LPH), α-melanocyte stimulating hormone (α-MSH) or N-acetyl-β-END (Nac-β-END)] have any influences on monocyte deactivation as a major factor of immunosuppression under septic shock conditions. Sixteen patients with septic shock were enrolled in a double-blind, cross-over and placebo controlled clinical study; 0.5μg/(kgbodyweighth) CRH (or placebo) were intravenously administered for 24h. Using flow cytometry we investigated the immunosuppression in patients as far as related to the loss of leukocyte surface antigen-DR expression on circulating monocytes (mHLA-DR). ACTH, β-END immunoreacive material (IRM), β-LPH IRM, α-MSH and Nac-β-END IRM as well as TNF-α and mHLA-DR expression were determined before, during and after treatment with CRH (or placebo). A significant correlation between plasma concentration of α-MSH and mHLA-DR expression and an inverse correlation between mHLA-DR expression and TNF-α plasma level were found. Additionally, a significant increase of mHLA-DR expression was observed 16h after starting the CRH infusion; 8h later, the mHLA-DR expression had decreased again. Our results indicate that the up-regulation of mHLA-DR expression after CRH infusion is not dependent on the release of POMC derivatives. From the correlation between plasma concentration of α-MSH and mHLA-DR expression, we conclude that in patients with septic shock the down-regulation of mHAL-DR expression is accompanied by the loss of monocytic release of α-MSH into the cardiovascular compartment. PMID:23891702

  12. Apigenin potentiates TRAIL therapy of non-small cell lung cancer via upregulating DR4/DR5 expression in a p53-dependent manner

    PubMed Central

    Chen, Minghui; Wang, Xueshi; Zha, Daolong; Cai, Fangfang; Zhang, Wenjing; He, Yan; Huang, Qilai; Zhuang, Hongqin; Hua, Zi-Chun

    2016-01-01

    Apigenin (APG) is an edible plant-derived flavonoid that shows modest antitumor activities in vitro and in vivo. APG treatment results in cell growth arrest and apoptosis in various types of tumors by modulating several signaling pathways. In the present study, we evaluated interactions between APG and TRAIL in non-small cell lung cancer (NSCLC) cells. We observed a synergistic effect between APG and TRAIL on apoptosis of NSCLC cells. A549 cells and H1299 cells were resistant to TRAIL treatment alone. The presence of APG sensitized NSCLC cells to TRAIL-induced apoptosis by upregulating the levels of death receptor 4 (DR4) and death receptor 5 (DR5) in a p53-dependent manner. Consistently, the pro-apoptotic proteins Bad and Bax were upregulated, while the anti-apoptotic proteins Bcl-xl and Bcl-2 were downregulated. Meanwhile, APG suppressed NF-κB, AKT and ERK activation. Treatment with specific small-molecule inhibitors of these pathways enhanced TRAIL-induced cell death, mirroring the effect of APG. Furthermore, using a mouse xenograft model, we demonstrated that the combined treatment completely suppressed tumor growth as compared with APG or TRAIL treatment alone. Our results demonstrate a novel strategy to enhance TRAIL-induced antitumor activity in NSCLC cells by APG via inhibition of the NF-κB, AKT and ERK prosurvival regulators. PMID:27752089

  13. [The life of Dr. John William Heron, the second superintendent of Chejungwon].

    PubMed

    Kim, D K; Kim, T S

    2000-12-01

    The purpose of this paper is to overview the life of John W. Heron, M. D. who was the first appointed medical missionary to Korea by the Presbyterian Church USA. Although he was a competent doctor as well as a devoted missionary, he is not well-known yet, because he died early after 5 years' service in Korea. Dr. Heron was born in Derbyshire, England on June 15, 1856. His father, Rev. E. S. Heron, was a Scotch Minister of Congregational Church. His family emigrated to America in 1870 when he was fourteen years old and settled in Knoxville, Tennessee. In 1881, he was admitted to the University of Tennessee Medical School and graduated with highest honors in 1883. After training in New York University Hospital, he refused the offer of professorship from the University of Tennessee to become a medical missionary to Korea. He arrived in Seoul on June 21, 1885 and began to work in Royal Government Hospital, Chejungwon, the predecessor of Severance Hospital. In 1887, he became the superintendent of the Hospital following Dr. Horace N. Allen. He also worked for the Royal family and sometimes traveled to the rural areas to care for the patients. He started Chejungwon Church which later became Namdaemoon Presbyterian Church. In 1887, Dr. Heron worked as a member of the Bible translation committee and in 1889, he was elected as the chairman of the Public Committee of the Presbyterian Churches. In 1890, he established 'The Korean Religious Tract Society (Chosunsyungkyoseohoi) with Underwood and Ohlinger. The society published and replenished Christian books, periodical magazines and booklets. In the Summer of 1890, Dr. Heron did his best to take care of the sick suffering from an epidemic dysentery and himself got infected because of the terrible overwork. He passed away on July 26th, 1890. On his deathbed, he told his soldier and native friends around him as follow: "Jesus loves you. He gave His life for you. Stand by Him!" The martyrdom of Dr. Heron should be remembered in

  14. Talking the Higgs Boson with Dr. Joseph Incandela: Third Lecture in the DOE Science Speaker Series (includes opening remarks from Dr. Bill Brinkman and introduction by Energy Secretary, Dr. Steven Chu)

    SciTech Connect

    Incandela, Joseph

    2012-09-14

    In July of 2012, scientists leading two different research teams, working independently of each other, announced that they had almost certain proof of the long-sought Higgs boson. Though Cern did not call the discovery "official", many physicists conceded the evidence was now so compelling they had surely found the missing particle. The formal confirmation will come over the next few months of further investigation. The experiments are taking place at the Large Hadron Collider (LHC), and this third lecture in the DOE Science Speaker Series is given by one of those announcing scientists in July. He is Dr. Joseph Incandela, the current spokesperson for the Compact Muon Solenoid (CMS) Experiment at CERN. He was heavily involved in the search for the top quark at Fermi and is from the University of California, Santa Barbara. The title he gives his presentation is "Searching for the genetic code of our universe: Discovery at the LHC."

  15. Paradoxical activation of MEK/ERK signaling induced by B-Raf inhibition enhances DR5 expression and DR5 activation-induced apoptosis in Ras-mutant cancer cells.

    PubMed

    Oh, You-Take; Deng, Jiusheng; Yue, Ping; Sun, Shi-Yong

    2016-01-01

    B-Raf inhibitors have been used for the treatment of some B-Raf-mutated cancers. They effectively inhibit B-Raf/MEK/ERK signaling in cancers harboring mutant B-Raf, but paradoxically activates MEK/ERK in Ras-mutated cancers. Death receptor 5 (DR5), a cell surface pro-apoptotic protein, triggers apoptosis upon ligation with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) or aggregation. This study focused on determining the effects of B-Raf inhibition on DR5 expression and DR5 activation-induced apoptosis in Ras-mutant cancer cells. Using chemical and genetic approaches, we have demonstrated that the B-Raf inhibitor PLX4032 induces DR5 upregulation exclusively in Ras-mutant cancer cells; this effect is dependent on Ras/c-Raf/MEK/ERK signaling activation. PLX4032 induces DR5 expression at transcriptional levels, largely due to enhancing CHOP/Elk1-mediated DR5 transcription. Pre-exposure of Ras-mutated cancer cells to PLX4032 sensitizes them to TRAIL-induced apoptosis; this is also a c-Raf/MEK/ERK-dependent event. Collectively, our findings highlight a previously undiscovered effect of B-Raf inhibition on the induction of DR5 expression and the enhancement of DR5 activation-induced apoptosis in Ras-mutant cancer cells and hence may suggest a novel therapeutic strategy against Ras-mutated cancer cells by driving their death due to DR5-dependent apoptosis through B-Raf inhibition.

  16. GENESI-DR - A single access point to Earth Science data

    NASA Astrophysics Data System (ADS)

    Cossu, R.; Goncalves, P.; Pacini, F.

    2009-04-01

    The amount of information being generated about our planet is increasing at an exponential rate, but it must be easily accessible in order to apply it to the global needs relating to the state of the Earth. Currently, information about the state of the Earth, relevant services, analysis results, applications and tools are accessible in a very scattered and uncoordinated way, often through individual initiatives from Earth Observation mission operators, scientific institutes dealing with ground measurements, service companies, data catalogues, etc. A dedicated infrastructure providing transparent access to all this will support Earth Science communities by allowing them to easily and quickly derive objective information and share knowledge based on all environmentally sensitive domains. The use of high-speed networks (GÉANT) and the experimentation of new technologies, like BitTorrent, will also contribute to better services for the Earth Science communities. GENESI-DR (Ground European Network for Earth Science Interoperations - Digital Repositories), an ESA-led, European Commission (EC)-funded two-year project, is taking the lead in providing reliable, easy, long-term access to Earth Science data via the Internet. This project will allow scientists from different Earth Science disciplines located across Europe to locate, access, combine and integrate historical and fresh Earth-related data from space, airborne and in-situ sensors archived in large distributed repositories. GENESI-DR builds a federated collection of heterogeneous digital Earth Science repositories to establish a dedicated infrastructure providing transparent access to all this and allowing Earth Science communities to easily and quickly derive objective information and share knowledge based on all environmentally sensitive domains. The federated digital repositories, seen as services and data providers, will share access to their resources (catalogue functions, data access, processing services etc

  17. Dr Google

    PubMed Central

    Pías-Peleteiro, Leticia; Cortés-Bordoy, Javier; Martinón-Torres, Federico

    2013-01-01

    Objectives: To assess and analyze the information and recommendations provided by Google Web Search™ (Google) in relation to web searches on the HPV vaccine, indications for females and males and possible adverse effects. Materials and Methods: Descriptive cross-sectional study of the results of 14 web searches. Comprehensive analysis of results based on general recommendation given (favorable/dissuasive), as well as compliance with pre-established criteria, namely design, content and credibility. Sub-analysis of results according to site category: general information, blog / forum and press. Results: In the comprehensive analysis of results, 72.2% of websites offer information favorable to HPV vaccination, with varying degrees of content detail, vs. 27.8% with highly dissuasive content in relation to HPV vaccination. The most frequent type of site is the blog or forum. The information found is frequently incomplete, poorly structured, and often lacking in updates, bibliography and adequate citations, as well as sound credibility criteria (scientific association accreditation and/or trust mark system). Conclusions: Google, as a tool which users employ to locate medical information and advice, is not specialized in providing information that is necessarily rigorous or valid from a scientific perspective. Search results and ranking based on Google's generalized algorithms can lead users to poorly grounded opinions and statements, which may impact HPV vaccination perception and subsequent decision making. PMID:23744505

  18. Dr. Artist.

    ERIC Educational Resources Information Center

    Lightfoot, Thomas R.

    The world is in the middle of a major paradigm shift, as the paradigm of dominion over nature is coming to an end with the acceptance of the arts and other subjectively oriented technologies as useful in our effort to live in the universe. Little by little, awareness of this fundamental change in world view is emerging. The importance of art in…

  19. VizieR Online Data Catalog: VPHAS+ DR2 survey (Drew+, 2016)

    NASA Astrophysics Data System (ADS)

    Drew, J. E.; Gonzalez-Solares, E.; Greimel, R.; Irwin, M. J.; Kupcu Yoldas, A.; Lewis, J.; Barentsen, G.; Eisloffel, J.; Farnhill, H. J.; Martin, W. E.; Walsh, J. R.; Walton, N. A.; Mohr-Smith, M.; Raddi, R.; Sale, S. E.; Wright, N. J.; Groot, P.; Barlow, M. J.; Corradi, R. L. M.; Drake, J. J.; Fabregat, J.; Frew, D. J.; Gansicke, B. T.; Knigge, C.; Mampaso, A.; Morris, R. A. H.; Naylor, T.; Parker, Q. A.; Phillipps, S.; Ruhland, C.; Steeghs, D.; Unruh, Y. C.; Vink, J. S.; Wesson, R.; Zijlstra, A. A.

    2016-10-01

    The Second VPHAS data release (DR2) covers the first 21 months of data-taking in which the survey progressed to 24 percent completion. Much of the Galactic mid-plane is now covered (especially in the r, i and Hα filters). This release supersedes DR1. For access to the release documents and ESO archive entry, see ESO's public survey pages (http://eso.org/rm/publicAccess#/dataReleases). The appropriate journal reference for the use of VPHAS+data is to: Drew et al., 2014MNRAS.440.2036D. If making use of data from this release, please use the following statement in the acknowledgements: "Based on data products from observations made with ESO Telescopes at the La Silla Paranal Observatory under public survey programme ID, 177.D-3023". (1 data file).

  20. Dr Karel Fleischmann: the story of an artist and physician in Ghetto Terezin.

    PubMed

    Hoenig, Leonard J; Spenser, Tomas; Tarsi, Anita

    2004-02-01

    Dr Karel Fleischmann (1897-1944) was a Jewish dermatologist and noted Czech artist. During World War II, Fleischmann was confined by the Nazis in Ghetto Terezin (Theresienstadt), which was located in the Protectorate of Bohemia and Moravia. While at Terezin, Fleischmann became a leader of the ghetto's health care system and administered programs that helped to dramatically reduce the high mortality rate of the Jewish population from disease. In his spare time, Fleischmann drew works of art that portrayed the daily life and suffering of the Jews in Ghetto Terezin. Although Fleischmann perished in the Auschwitz-Birkenau concentration camp, his artwork survived the war. This article pays tribute to Dr Karel Fleischmann by telling the story of his life and by citing selections from his art, poetry and prose. PMID:15125504

  1. The Southern Surgical Association History of Medicine Scholarship presentation: Dr. Charles Drew, a surgical pioneer.

    PubMed

    Cornwell, Edward E; Chang, David C; Leffall, LaSalle D

    2006-05-01

    When one considers the circumstances of his birth, the barriers that he had to overcome, and his abbreviated life span (<46 years), a strong case can be made that Charles Drew, MD, CM, MDSc, was one of the most accomplished surgeons of the 20th Century; yet many practitioners and instructors of the surgical sciences know little or nothing about him. There are others who have heard of him and still harbor popular misconceptions about the circumstances of his death that have been perpetuated by several media outlets. The Southern Surgical Association promotes a substantially more inclusive brand of surgical fellowship than it did during the lifetime of Dr. Drew. We believe that the membership would greatly appreciate knowing some of the details of Dr. Drew's life, particularly his major scientific contributions and his commitment to excellence in patient care, and in the training of young surgeons.

  2. GENESI-DR: Discovery, Access and on-Demand Processing in Federated Repositories

    NASA Astrophysics Data System (ADS)

    Cossu, Roberto; Pacini, Fabrizio; Parrini, Andrea; Santi, Eliana Li; Fusco, Luigi

    2010-05-01

    GENESI-DR (Ground European Network for Earth Science Interoperations - Digital Repositories) is a European Commission (EC)-funded project, kicked-off early 2008 lead by ESA; partners include Space Agencies (DLR, ASI, CNES), both space and no-space data providers such as ENEA (I), Infoterra (UK), K-SAT (N), NILU (N), JRC (EU) and industry as Elsag Datamat (I), CS (F) and TERRADUE (I). GENESI-DR intends to meet the challenge of facilitating "time to science" from different Earth Science disciplines in discovery, access and use (combining, integrating, processing, …) of historical and recent Earth-related data from space, airborne and in-situ sensors, which are archived in large distributed repositories. In fact, a common dedicated infrastructure such as the GENESI-DR one permits the Earth Science communities to derive objective information and to share knowledge in all environmental sensitive domains over a continuum of time and a variety of geographical scales so addressing urgent challenges such as Global Change. GENESI-DR federates data, information and knowledge for the management of our fragile planet in line with one of the major goals of the many international environmental programmes such as GMES, GEO/GEOSS. As of today, 12 different Digital Repositories hosting more than 60 heterogeneous dataset series are federated in GENESI-DR. Series include satellite data, in situ data, images acquired by airborne sensors, digital elevation models and model outputs. ESA has started providing access to: Category-1 data systematically available on Internet; level 3 data (e.g., GlobCover map, MERIS Global Vegetation Index); ASAR products available in ESA Virtual Archive and related to the Supersites initiatives. In all cases, existing data policies and security constraints are fully respected. GENESI-DR also gives access to Grid and Cloud computing resources allowing authorized users to run a number of different processing services on the available data. The GENESI-DR

  3. HLA-DR, DP and DQ expression in the small intestine of patients with coeliac disease.

    PubMed Central

    Marley, N J; Macartney, J C; Ciclitira, P J

    1987-01-01

    Frozen sections of jejunal mucosa from control subjects and patients with both treated and untreated coeliac disease were examined for HLA class II DR, DP and DQ expression. Different staining patterns with monoclonal antibodies to the different class II subgroups were observed with the control subjects. There was some inter-subject variation but in general DR greater than DP greater than DQ staining was observed with the villous enterocytes staining most strongly with the staining decreasing towards the crypt bases. The patients with treated coeliac disease gave a similar pattern to the controls. The patients with untreated coeliac disease generally gave a more intense and relatively uniform staining of both surface and crypt enterocytes for all class II subgroups. Images Fig. 1 Fig. 3 Fig. 4 Fig. 5 PMID:3322617

  4. Oh, the places you may go--just follow Dr. Seuss.

    PubMed

    Luechauer, David; Baum, Neil

    2015-01-01

    All physicians have mentors, role models, and even historical figures in medicine to whom they turn for advice on everything from treating their patients to running their practices. To be sure, many physicians have learned valuable lessons from Osler, Halstead, Fleming, Pasteur, and a long list of former professors, supervisors, and practice partners. In this article, however, we suggest that modern physicians can turn to a most unlikely source of wisdom and knowledge. We would like to put the spotlight on another doctor--Dr. Seuss. It may be hard to believe, but modern physicians can learn much about the care of patients and the business of running their practices from the very same books they are reading with their children and grandchildren. The idea that well-trained and sophisticated physicians can learn from Dr. Seuss is not as far-fetched as it may seem initially. PMID:26062332

  5. [The anatomy Lesson of Dr. Nicolaes Tulp: The beginning of a medical utopia].

    PubMed

    Rosler, Roberto; Young, Pablo

    2011-04-01

    The Anatomy Lesson of Dr. Nicolaes Tulp was painted by Rembrandt Harmen-szoon van Rijn at the early age of 26 years. In the XVII century these paintings were very popular in the Netherlands, and in this country the cities flourished as cultural centers searching the anatomy knowledge. Nicolaes Tulp was one of the persons in the center of Amsterdam's scene during XVII century. In 1632 Tulp was 39 years old, and he was an anatomist and a surgeon. Rembrandt masterly shows an autopsy performed by Dr. Tulp. This picture is the description of the beginning of a medical intellectual utopia: the absolute visibility of the disease. Unfortunately this utopia is blind to the complete visibility of the psycho-socio-cultural dimensions of the ill. PMID:21879195

  6. Spectral properties of the extreme solar system objects 2012 DR30 and 2013 AZ60

    NASA Astrophysics Data System (ADS)

    Szabo, G.; Kiss, Cs.; Duffard, R.; Pinilla-Alonso, N.; Licandro, J.

    2014-04-01

    2012 DR30 and 2013 AZ60 represent two examples of TNOs with very large aphelion distances (2405 and 1951 AU, respectively), thus standing for the currently best candidates of possible scattered-in Oort-cloud objects. Though they possibly shared a similar dynamical scenario, the two bodies exhibit surprisingly diverging prediction for orbital evolution and also quite different surface properties (Kiss et al. 2013, Kiss et al. 2014). Here we compare these optical and infrared photometry and spectra of the two bodies. Both show a generaly flat spectrum, but with significantly differing slope. We find clear signs of water ice on 2013 DR30 particulary, which is an exciting diagnostic of a possible water reservoir at very large perihelion distances, and on the other hand, suggests a close link between the giant cometary nuclei of the Oort Cloud (for that Hale-Bopp is the only known example in our Solar System) and these exotic TNOs.

  7. Human leukocyte antigen (HLA) DR4. Positive association with rapidly progressing periodontitis.

    PubMed

    Katz, J; Goultschin, J; Benoliel, R; Brautbar, C

    1987-09-01

    The relationship between human leukocyte antigens (HLA) determinants and periodontitis has been examined by several authors without showing any particular pattern. However, no study has investigated the HLA-D determinants, which are generally associated with immune disorders, and rapidly progressive periodontitis (RPP). The HLA profile of 10 RPP patients was compared with that of a healthy control population (n = 120). Although no significant difference was found for HLA-A, HLA-B, and HLA-C, HLA-DR4 of the HLA-D group was found in 80% of patients but only in 38.3% of controls. A high frequency of HLA-DR4 has been reported in rheumatoid arthritis (RA) patients. This finding may be significant in light of previous reports highlighting similarities between RA and periodontal disease. PMID:3498813

  8. Dr. Yvonne Pendleton: A Prestigious Role Model of the 21st Century

    NASA Astrophysics Data System (ADS)

    Flores, Gustavo; Prado, Hilary

    2009-10-01

    This project embodies the progression of Dr. Yvonne Pendleton through the beginnings of her fascination with science, her achievements in astrophysics, and contributions to scientific communities as a whole. As a woman of authority in a male-dominated field of study, Dr. Yvonne Pendleton has challenged the misconception that society attains of women in physics. As Senior Advisor for Research and Analysis for NASA, she recently investigated the organic component of the interstellar medium and the incorporation of that material into the early solar nebula. Through various obstacles, she continues to devote much of her free time to the encouragement of students at the high school, collegiate, graduate, and post-graduate levels.

  9. VERY LARGE ARRAY DETECTION OF THE 36 GHz ZEEMAN EFFECT IN DR21W REVISITED

    SciTech Connect

    Momjian, Emmanuel; Sjouwerman, Lorant O.; Fish, Vincent L.

    2012-09-20

    We report on the observation of the 36 GHz methanol maser line in the star-forming region DR21W to accurately measure the Zeeman effect. The Zeeman signature reported by Fish et al. became suspicious after an instrumental effect was discovered in the early days of the commissioning of the Very Large Array Wide-band Digital Architecture correlator. We conclude that the previously reported magnetic field strength of 58 mG (1.7 Hz mG{sup -1}/z) is instrumental in nature and thus incorrect. With the improved performance of the array, we now deduce a 3{sigma} limit of -4.7 to +0.4 mG (1.7 Hz mG{sup -1}/z) for the line-of-sight component of the magnetic field strength in DR21W.

  10. Dr. William Theodore Hodge: pioneer surgeon-apothecary in early-twentieth-century Western Australia.

    PubMed

    Kamien, Max

    2010-01-01

    In 2008 I chanced upon the lonely grave of Dr. William Theodore Hodge, buried in 1934, in the Derby Pioneer and Aboriginal Cemetery. He turned out to be the founding doctor of the practice in which I have worked for the past thirty years. Dr. Hodge migrated from England in 1896. He was the first western trained doctor to work in the Perth suburb of Claremont and in the wheat-belt town of Kellerberrin. He was an innovative and inventive modern doctor who became a legend in the Kimberley where he died tragically, on the day prior to his retirement, at the age of seventy-five. His story is illustrative of the life and medical practice of a pioneering doctor in metropolitan, rural, and remote practice in Western Australia at the end of the nineteenth and the early years of the twentieth centuries. PMID:20973339

  11. Dr. Smith Goes to Washington: A Physicist Wanders the Halls of Congress

    SciTech Connect

    Tannenbaum, Benn

    2005-03-23

    Dr. Tannenbaum was the 2002-2003 APS Congressional Science Fellow. He worked in the office of U.S. Rep. Edward Markey (D-MA) on nuclear nonproliferation issues. His work in Congressman Markey's office focused on issues including missile defense, the nuclear program in Iran, prevention of the transfer of U.S. nuclear technology to North Korea, and the security of nuclear sites in Iraq. Dr. Tannenbaum will discuss this experience and observations concerning 'underinformed and uninformed' decision-making in Congress. He will also briefly discuss goals of the Center for Science, Technology and Security Policy at the American Association for the Advancement of Science. Finally, he will discuss ways in which physicists can get more involved in the political process.

  12. [The anatomy Lesson of Dr. Nicolaes Tulp: The beginning of a medical utopia].

    PubMed

    Rosler, Roberto; Young, Pablo

    2011-04-01

    The Anatomy Lesson of Dr. Nicolaes Tulp was painted by Rembrandt Harmen-szoon van Rijn at the early age of 26 years. In the XVII century these paintings were very popular in the Netherlands, and in this country the cities flourished as cultural centers searching the anatomy knowledge. Nicolaes Tulp was one of the persons in the center of Amsterdam's scene during XVII century. In 1632 Tulp was 39 years old, and he was an anatomist and a surgeon. Rembrandt masterly shows an autopsy performed by Dr. Tulp. This picture is the description of the beginning of a medical intellectual utopia: the absolute visibility of the disease. Unfortunately this utopia is blind to the complete visibility of the psycho-socio-cultural dimensions of the ill.

  13. VizieR Online Data Catalog: Compact groups of galaxies in SDSS DR7 (Mendel+, 2011)

    NASA Astrophysics Data System (ADS)

    Mendel, J. T.; Ellison, S. L.; Simard, L.; Patton, D. R.; McConnachie, A. W.

    2012-07-01

    In Paper III (Cat. J/MNRAS/395/255) we describe the photometric selection of CGs from the SDSS Data Release 6 (Adelman-McCarthy et al., 2008, Cat. II/282/), which included imaging of the entire SDSS-II Legacy Survey area. Since that paper, SDSS Data Release 7 (DR7; Abazajian et al., 2009ApJS..182..543A) has provided an additional ~1200deg2 of spectroscopic data, completing spectroscopic observations of the SDSS-II Legacy Survey footprint. In what follows we use galaxy catalogues drawn from SDSS DR7 and, where available, supplement the CG samples in Paper III with updated spectroscopic information. (2 data files).

  14. Objective measures of laryngeal imaging: what have we learned since Dr. Paul Moore.

    PubMed

    Woo, Peak

    2014-01-01

    Dr. Paul Moore pioneered the use of high-speed cinematography for observation of normal and abnormal vocal fold vibrations during phonation. His analysis of the glottal area waveform, opening and closing speed index, and open quotient from the high-speed films were labor intensive but relevant today. With advances in digital image capture and automated image extraction techniques, stroboscopy and high-speed images of vocal fold vibration may be analyzed with objective measures. Digital high-speed image capture in color is now clinically practical at high resolution. Digital kymography now allows analysis of the vibratory waveform from each vocal fold. Serial capture and comparison can document changes in vibratory function with treatment. Quantification of vocal fold vibration using such techniques is now practical. This is a review of vocal fold vibration capture and analysis techniques since Dr. Moore. PMID:24094798

  15. Duplication of the DR3 gene on human chromosome 1p36 and its deletion in human neuroblastoma.

    PubMed

    Grenet, J; Valentine, V; Kitson, J; Li, H; Farrow, S N; Kidd, V J

    1998-05-01

    The human DR3 gene, whose product is also known as Wsl-1/APO-3/TRAMP/LARD, encodes a tumor necrosis factor-related receptor that is expressed primarily on the surface of thymocytes and lymphocytes. DR3 is capable of inducing both NF-kappa B activation and apoptosis when overexpressed in mammalian cells, although its ligand has not yet been identified. We report here that the DR3 gene locus is tandemly duplicated on human chromosome band 1p36.2-p36.3 and that these genes are hemizygously deleted and/or translocated to another chromosome in neuroblastoma (NB) cell lines with amplified MYCN. Duplication of at least a portion of the DR3 gene, including the extracellular and transmembrane regions but not the cytoplasmic domain, was demonstrated by both fluorescence in situ hybridization and genomic Southern blotting. In most NB cell lines, both the DR3 and the DR3L sequences are simultaneously deleted and/or translocated to another chromosome. Finally, DR3/ Wsl-1 protein expression is quite variable among these NB cell lines, with very low or undetectable levels in 7 of 17 NB cell lines.

  16. MONOCYTE HUMAN LEUKOCYTE ANTIGEN–DR EXPRESSION—A TOOL TO DISTINGUISH INTESTINAL BACTERIAL INFECTIONS FROM INFLAMMATORY BOWEL DISEASE?

    PubMed Central

    Tillinger, Wolfgang; Jilch, Ruth; Waldhoer, Thomas; Reinisch, Walter; Junger, Wolfgang

    2014-01-01

    Background We sought to determine the quantitative expression of human leukocyte antigen–DR (HLA-DR) on monocytes in patients with acute intestinal bacterial infections and inflammatory bowel disease (IBD). Methods The quantitative expression of HLA-DR on monocytes was determined by fluorescence-activated cell sorting analysis in patients with IBD, patients with acute intestinal bacterial infections (bact.), and healthy subjects (contr.). Results The quantitative expression of HLA-DR in patients with bact. (n = 20; 90,000 molecules per monocyte; confidence interval [CI], 79,000–102,000) was significantly higher than that in patients with ulcerative colitis (n = 40, 30,000; CI, 30,000–38,000; P < 0.0001), Crohn disease (n = 80, 31,000; CI, 32,000–39,000; P < 0.0001), or in contr. (n = 28, 39,000; CI, 36,000–46,000; P < 0.0001). In patients with ulcerative colitis and Crohn disease, HLA-DR expression was significantly decreased, as compared with contr. (P < 0.05 and P < 0.01, respectively). With a cutoff point of 50,000, HLA-DR showed a sensitivity of 95% and a specificity of 92% in discriminating between bact. and active IBD. Conclusion The quantitative measurement of HLA-DR expression could serve as a valuable tool to discriminate between bact. and active IBD. PMID:23860582

  17. The presence of HLA-DR antigens on lactating human breast epithelium and milk fat globule membranes.

    PubMed Central

    Newman, R A; Ormerod, M G; Greaves, M F

    1980-01-01

    HLA-DR antigens have been demonstrated on the secretory epithelia of lactating breast using rabbit anti-p28,33 ('Ia-like') and mouse monoclonal anti-HLA-DR 'framework'. Normal non-lactating breast, benign or malignant tumours, epithelial cells from normal breast or isolated from milk and a presumptive breast carcinoma cell line (MCF-7) were all HLA-DR-negative. HLA-DR, HLA (ABC 'framework') and beta 2-microglobulin determinants were also demonstrated on the surface of milk fat globules (MFG) which were unreactive with monoclonal antibodies to thymus cells or leucocytes. A monoclonal antibody detecting allelic HLA-DR determinants (HLA-DRw 1,2,6) was positive on 40% of MFG samples tested, positive reactions being concordant, when tested, with blood B lymphocytes. Antisera raised against MFG membranes also contain anti-HLA-DR activity. Whether the breast epithelial cells synthesize HLA-DR molecules or acquire these passively from mononuclear cells which infiltrate during lactation is not yet resolved. Images Fig. 1 PMID:7002399

  18. With stroke of pen, FERC puts DR on par with supply side options

    SciTech Connect

    2009-01-15

    In mid October 2008, the Federal Energy Regulatory Commission (FERC) finalized new rules intended to strengthen the operation and improve the competitiveness of organized U.S. wholesale electric markets. FERC intends to increase the use of demand response (DR), encourage long-term power contracts, strengthen the role of market monitors, and enhance the responsiveness of regional transmission organizations (RTOs) and independent system operators (ISOs). The FERC order applies to existing U.S. organized wholesale markets.

  19. [The Nobel Prize for nitric oxide. The unjust exclusion of Dr. Salvador Moncada].

    PubMed

    de Berrazueta, J R

    1999-04-01

    The 1998 Nobel Prize in Physiology and Medicine has been awarded jointly to North-American scientists, Dr Robert F. Furchgott, Louis J. Ignarro and Ferid Murad, for their discoveries in relation to "nitric oxide as a signalling molecule in the cardiovascular system". This has raised an important polemic because of the exclusion the South-American scientist, now nationalized British, Dr. Salvador Moncada. This short historical review examines some of the fundamental contributions to the knowledge in this field. It shows the sequence of the discoveries and the communication of them to the scientific community by the rewarded scientists and by Dr. Moncada. It is based on some fundamental publications in order to better understand this story, which does not coincide with the writing in 1996 by the Lasker Prize Committee, and which in 1998 was re-written again by the Nobel Committee of the Swedish Academy. More than 90 universities, academies and societies have acknowledged Dr. Moncada up to now with priority in the discovery of the fact that nitric oxide is released by endothelial cells, and the revealing of its metabolic way. More than 20,000 citations of their fundamental papers endorse in the scientific community his primacy in this field. Even Robert Furchgott, author of the brilliant discovery of the endothelium derived relaxing factor, that opened this field to the science, declared about the award of the 1998 Nobel Prize: "I feel that the Nobel Prize Committee could have made an exception this year and chosen a fourth person, Salvador Moncada (to share the prize)".

  20. Dr. Hans Rosling, Keynote - 2013 ARPA-E Energy Innovation Summit

    SciTech Connect

    Rosling, Hans

    2014-03-06

    The fourth annual ARPA-E Energy Innovation Summit was held in Washington D.C. in February, 2013. The event brought together key players from across the energy ecosystem - researchers, entrepreneurs, investors, corporate executives, and government officials - to share ideas for developing and deploying the next generation of energy technologies. Dr. Hans Rosling (Professor, International Health, Karolinska Institute; Edutainer, Gapminder.org), gave this keynote address.

  1. Dr. Hans Rosling, Keynote - 2013 ARPA-E Energy Innovation Summit

    ScienceCinema

    Rosling, Hans (Professor, International Health, Karolinska Institute; Edutainer, Gapminder.org)

    2016-07-12

    The fourth annual ARPA-E Energy Innovation Summit was held in Washington D.C. in February, 2013. The event brought together key players from across the energy ecosystem - researchers, entrepreneurs, investors, corporate executives, and government officials - to share ideas for developing and deploying the next generation of energy technologies. Dr. Hans Rosling (Professor, International Health, Karolinska Institute; Edutainer, Gapminder.org), gave this keynote address.

  2. Dr. Robert S. Harris: nutritionist, oral science researcher, and visionary MIT educator.

    PubMed

    Navia, J M

    1998-03-01

    Efforts in dental research and training have received the contribution of individuals who had no formal training in dentistry, yet they understood the dental field and the educational needs of those who would be engaged in dental research, teaching, and service in industry and academia. Dr. Robert S. Harris (1904-1983) was such a man. What follows is a personal remembrance of his character, his research accomplishments, and his successful educational endeavors in the dental field. PMID:9496916

  3. Dr. David Brown poses with a portrait of Ronald McNair

    NASA Technical Reports Server (NTRS)

    1999-01-01

    In the gymnasium of Ronald McNair Magnet School in Cocoa, Fla., Dr. David Brown, a NASA astronaut, poses with a portrait of NASA astronaut Ronald McNair. The portrait was presented to the school by Walt Disney World during a tribute to McNair. The school had previously been renamed for the fallen astronaut who was one of a crew of seven who lost their lives during an accident following launch of the Space Shuttle Challenger in January 1986.

  4. Community control of health services. Dr. Martin Luther King, Jr. Health Center's community management system.

    PubMed

    Tichy, N M; Taylor, J I

    1976-01-01

    This article presents the case of Dr. Martin Luther King Jr. Health Center's unique community management system in which neighborhood workers have been developed to assume managerial responsibilities and are directing the Center. The Martin Luther King Center experience is instructive because the Center was able to achieve significant community control by focusing primarily on the internal dimension of control, namely, management, without experiencing destructive conflicts and the deterioration of health services.

  5. Dr. Marco Marra: Pioneer and Visionary in Cancer Genomics Research | Office of Cancer Genomics

    Cancer.gov

    Dr. Marco Marra is a highly distinguished genomics and bioinformatics researcher. He is the Director of Canada’s Michael Smith Genome Sciences Centre at the BC Cancer Agency and holds a faculty position at the University of British Columbia. The Centre is a state-of-the-art sequencing facility in Vancouver, Canada, with a major focus on the study of cancers.  Many of their research projects are undertaken in collaborations with other Canadian and international institutions.

  6. Leading Healthcare Change Across the Care Continuum: An Interview With Dr Kenneth Rempher.

    PubMed

    Murphy, Lyn Stankiewicz; Joseph, M Lindell

    2016-01-01

    Kenneth Rempher, PhD, MBA, CENP, RN, is the chief nursing officer for the University of Iowa (UI) Hospitals and Clinics. In his 20-year career, he has distinguished himself as a visionary healthcare leader. Colleagues describe Dr Rempher as a strong, transformational leader, guiding the UI enterprise through a time of uncertainty and change. This interview by the CGEAN provides insight to his leadership style, successes, and ideas on the future of care delivery. PMID:27442899

  7. A study in dualism: The strange case of Dr. Jekyll and Mr. Hyde.

    PubMed

    Singh, Shubh M; Chakrabarti, Subho

    2008-07-01

    R. L. Stevenson's novel, The Strange Case of Dr. Jekyll and Mr. Hyde is a prominent example of Victorian fiction. The names Jekyll and Hyde have become synonymous with multiple personality disorder. This article seeks to examine the novel from the view point of dualism as a system of philosophy and as a religious framework and also from the view point of Freud's structural theory of the mind. PMID:19742237

  8. Leading Healthcare Change Across the Care Continuum: An Interview With Dr Kenneth Rempher.

    PubMed

    Murphy, Lyn Stankiewicz; Joseph, M Lindell

    2016-01-01

    Kenneth Rempher, PhD, MBA, CENP, RN, is the chief nursing officer for the University of Iowa (UI) Hospitals and Clinics. In his 20-year career, he has distinguished himself as a visionary healthcare leader. Colleagues describe Dr Rempher as a strong, transformational leader, guiding the UI enterprise through a time of uncertainty and change. This interview by the CGEAN provides insight to his leadership style, successes, and ideas on the future of care delivery.

  9. An interview with Dr Kenneth Kornman. Interview by David W Richards.

    PubMed

    Kornman, Kenneth

    2011-10-01

    Inflammation is recognized as the major underlying contributor to a number of chronic diseases, amongst them periodontitis and cardiovascular diseases. The relationship between these diseases is explored and commented on in this question-and-answer session between Ken Kornman, D.D.S., Ph.D., the editor of the Journal of Periodontology and David Richards, D.D.S., Ph.D., a former student of Dr. Kornman's. Practical suggestions and guidelines for the dentist are also examined.

  10. Dr. Zompo: an online data repository for Zostera marina and Posidonia oceanica ESTs.

    PubMed

    Wissler, L; Dattolo, E; Moore, A D; Reusch, T B H; Olsen, J L; Migliaccio, M; Bornberg-Bauer, E; Procaccini, G

    2009-01-01

    As ecosystem engineers, seagrasses are angiosperms of paramount ecological importance in shallow shoreline habitats around the globe. Furthermore, the ancestors of independent seagrass lineages have secondarily returned into the sea in separate, independent evolutionary events. Thus, understanding the molecular adaptation of this clade not only makes significant contributions to the field of ecology, but also to principles of parallel evolution as well. With the use of Dr. Zompo, the first interactive seagrass sequence database presented here, new insights into the molecular adaptation of marine environments can be inferred. The database is based on a total of 14 597 ESTs obtained from two seagrass species, Zostera marina and Posidonia oceanica, which have been processed, assembled and comprehensively annotated. Dr. Zompo provides experimentalists with a broad foundation to build experiments and consider challenges associated with the investigation of this class of non-domesticated monocotyledon systems. Our database, based on the Ruby on Rails framework, is rich in features including the retrieval of experimentally determined heat-responsive transcripts, mining for molecular markers (SSRs and SNPs), and weighted key word searches that allow access to annotation gathered on several levels including Pfam domains, GeneOntology and KEGG pathways. Well established plant genome sites such as The Arabidopsis Information Resource (TAIR) and the Rice Genome Annotation Project are interfaced by Dr. Zompo. With this project, we have initialized a valuable resource for plant biologists in general and the seagrass community in particular. The database is expected to grow together with more data to come in the near future, particularly with the recent initiation of the Zostera genome sequencing project.The Dr. Zompo database is available at http://drzompo.uni-muenster.de/

  11. Dr. Zompo: an online data repository for Zostera marina and Posidonia oceanica ESTs.

    PubMed

    Wissler, L; Dattolo, E; Moore, A D; Reusch, T B H; Olsen, J L; Migliaccio, M; Bornberg-Bauer, E; Procaccini, G

    2009-01-01

    As ecosystem engineers, seagrasses are angiosperms of paramount ecological importance in shallow shoreline habitats around the globe. Furthermore, the ancestors of independent seagrass lineages have secondarily returned into the sea in separate, independent evolutionary events. Thus, understanding the molecular adaptation of this clade not only makes significant contributions to the field of ecology, but also to principles of parallel evolution as well. With the use of Dr. Zompo, the first interactive seagrass sequence database presented here, new insights into the molecular adaptation of marine environments can be inferred. The database is based on a total of 14 597 ESTs obtained from two seagrass species, Zostera marina and Posidonia oceanica, which have been processed, assembled and comprehensively annotated. Dr. Zompo provides experimentalists with a broad foundation to build experiments and consider challenges associated with the investigation of this class of non-domesticated monocotyledon systems. Our database, based on the Ruby on Rails framework, is rich in features including the retrieval of experimentally determined heat-responsive transcripts, mining for molecular markers (SSRs and SNPs), and weighted key word searches that allow access to annotation gathered on several levels including Pfam domains, GeneOntology and KEGG pathways. Well established plant genome sites such as The Arabidopsis Information Resource (TAIR) and the Rice Genome Annotation Project are interfaced by Dr. Zompo. With this project, we have initialized a valuable resource for plant biologists in general and the seagrass community in particular. The database is expected to grow together with more data to come in the near future, particularly with the recent initiation of the Zostera genome sequencing project.The Dr. Zompo database is available at http://drzompo.uni-muenster.de/ PMID:20157482

  12. [Establishment and application of DR automatic system based on DICOM3.0 BPE].

    PubMed

    Wang, Longchen; Hu, Shundong; Li, Bin

    2012-01-01

    This paper introduces a new application of PACS in our hospital. Through the integration of PACS, HIS and RIS, digital transformation is made in every step. The functional modules of Body Parts Examined in DICOM is set and good link between PACS and DR is made. So the equipment can retrieval the inspection area automatically and make adjustment on the parameters correspondingly. It makes the workflow optimized and improves the efficiency greatly. PMID:22571147

  13. A doctor's duty is to heal the unhealthy: the story of Tun Dr Mahathir Mohamad.

    PubMed

    Ong, H T

    2005-07-01

    Mahathir Mohamad was born in 1925 in Alor Star, Kedah. He entered the King Edward VII College of Medicine in Singapore in 1947 and graduated in 1953. His years in the medical school equipped young Mahathir with the training necessary to assess and diagnose a problem, before dispensing the appropriate treatment. Throughout his later years in the political limelight, Dr Mahathir recognised the very important role the medical college had in laying the strong foundation for his successful career. He joined UMNO in 1945, already interested in politics at the tender age of 20; he was first elected into Parliament in 1964. The vigorous expression of his candid views did not go down well during the troubled days following the 13 May 1969 racial riots and he was expelled from UMNO, his writings were banned, and he was considered a racial extremist. Nevertheless, his intellectual and political influence could not be ignored for long; he returned to Parliament in 1974, and became the fourth, and longest serving, Prime Minister of Malaysia in 1981. Dr Mahathir has found fame as a Malay statesman, and an important Asian leader of the twentieth century with much written, locally and internationally, debating his policies. This article, using Dr Mahathir's own writings, starts with his description of his early life, proceeds to look at his medical career, then touches on his diagnosis of the problems plaguing the Malays, before concluding with his views on the need to stand up to the prejudices and pressures of the Western world. Throughout his life, Dr Mahathir behaved as the ever-diligent medical doctor, constantly studying the symptoms to diagnose the cause of the ills in his community and country, before proceeding to prescribe the correct treatment to restore good health. It is a measure of his integrity and intellectual capability that he did not seek to hide his failures, or cite unfinished work in an attempt to cling to political power.

  14. DR-TAMAS: Diffeomorphic Registration for Tensor Accurate Alignment of Anatomical Structures.

    PubMed

    Irfanoglu, M Okan; Nayak, Amritha; Jenkins, Jeffrey; Hutchinson, Elizabeth B; Sadeghi, Neda; Thomas, Cibu P; Pierpaoli, Carlo

    2016-05-15

    In this work, we propose DR-TAMAS (Diffeomorphic Registration for Tensor Accurate alignMent of Anatomical Structures), a novel framework for intersubject registration of Diffusion Tensor Imaging (DTI) data sets. This framework is optimized for brain data and its main goal is to achieve an accurate alignment of all brain structures, including white matter (WM), gray matter (GM), and spaces containing cerebrospinal fluid (CSF). Currently most DTI-based spatial normalization algorithms emphasize alignment of anisotropic structures. While some diffusion-derived metrics, such as diffusion anisotropy and tensor eigenvector orientation, are highly informative for proper alignment of WM, other tensor metrics such as the trace or mean diffusivity (MD) are fundamental for a proper alignment of GM and CSF boundaries. Moreover, it is desirable to include information from structural MRI data, e.g., T1-weighted or T2-weighted images, which are usually available together with the diffusion data. The fundamental property of DR-TAMAS is to achieve global anatomical accuracy by incorporating in its cost function the most informative metrics locally. Another important feature of DR-TAMAS is a symmetric time-varying velocity-based transformation model, which enables it to account for potentially large anatomical variability in healthy subjects and patients. The performance of DR-TAMAS is evaluated with several data sets and compared with other widely-used diffeomorphic image registration techniques employing both full tensor information and/or DTI-derived scalar maps. Our results show that the proposed method has excellent overall performance in the entire brain, while being equivalent to the best existing methods in WM.

  15. A study in dualism: The strange case of Dr. Jekyll and Mr. Hyde

    PubMed Central

    Singh, Shubh M.; Chakrabarti, Subho

    2008-01-01

    R. L. Stevenson's novel, The Strange Case of Dr. Jekyll and Mr. Hyde is a prominent example of Victorian fiction. The names Jekyll and Hyde have become synonymous with multiple personality disorder. This article seeks to examine the novel from the view point of dualism as a system of philosophy and as a religious framework and also from the view point of Freud's structural theory of the mind. PMID:19742237

  16. VizieR Online Data Catalog: 188 CIV BAL QSOs from SDSS DR7 (He+, 2015)

    NASA Astrophysics Data System (ADS)

    He, Z.-C.; Bian, W.-H.; Ge, X.; Jiang, X.-L.

    2016-07-01

    In the SDSS DR7, it is found that there are 1080 spectra of 480 CIV BAL QSOs with at least two-epoch observations. In order to identify the variable regions in CIV BAL troughs, we select BAL QSOs with SDSS spectral signal-to-noise ratio (S/N) at r band larger than 10, and redshift more than 1.7. It consists of 188 CIV BAL QSOs with 428 SDSS spectra. (2 data files).

  17. HLA-DR polymorphism in a senegalese mandenka population: DNA oligotyping and population genetics of DRB1 specificities

    SciTech Connect

    Tiercy, J.M.; Shi-Isaac, X.; Jeannet, M.; Sanchez-Mazas, A.; Langaney, A.; Mach, B.; Excoffier, L.

    1992-09-01

    HLA class II loci are useful markers in human population genetics, because they are extremely variable and because new molecular techniques allow large-scale analysis of DNA allele frequencies. Direct DNA typing by hybridization with sequence-specific oligonucleotide probes (HLA oligotyping) after enzymatic in vitro PCR amplification detects HLA allelic polymorphisms for all class II loci. A detailed HLA-DR oligotyping analysis of 191 individuals from a geographically, culturally, and genetically well-defined western African population, the Mandenkalu, reveals a high degree of polymorphism, with at least 24 alleles and a heterozygosity level of .884 for the DRB1 locus. The allele DRB1[sup *]1304, defined by DNA sequencing of the DRB1 first-domain exon, is the most frequent allele (27.1%). It accounts for an unusually high DR13 frequency, which is nevertheless within the neutral frequency range. The next most frequency specificities are DR11, DR3, and DR8. Among DRB3-encoded alleles, DR52B (DRB3[sup *]02) represents as much as 80.7% of all DR52 halotypes. A survey of HLA-DR specificities in populations from different continents shows a significant positive correlation between genetic and geographic differentiation patterns. A homozygosity test for selective neutrality of DR specificities is not significant for the mandenka population but is rejected for 20 of 24 populations. Observed high heterozygosity levels in tested populations are compatible with an overdominant model with a small selective advantage for heterozygotes. 91 refs., 5 figs., 5 tabs.

  18. The presence of host-derived HLA-DR1 on human immunodeficiency virus type 1 increases viral infectivity.

    PubMed Central

    Cantin, R; Fortin, J F; Lamontagne, G; Tremblay, M

    1997-01-01

    Human immunodeficiency virus type 1 (HIV-1) incorporates several host cell components when budding out of the infected cell. One of the most abundant host-derived molecules acquired by HIV-1 is the HLA-DR determinant of the major histocompatibility complex class II (MHC-II) molecules. The fact that CD4 is the natural ligand of MHC-II prompted us to determine if such virally embedded cellular components can affect the biology of the virus. Herein, we report for the first time that the incorporation of cellular HLA-DR1 within HIV-1 enhances its infectivity. This observation was made possible with virions bearing or not bearing on their surfaces host-derived HLA-DR1 glycoproteins. Such virus stocks were prepared by a transient-expression system based on transfection of 293T cells with a recombinant luciferase-encoding HIV-1 molecular clone along with plasmids encoding the alpha and beta chains of HLA-DR1. Cell-free virions recovered from transfected cells were shown to have efficiently incorporated host-derived HLA-DR1 glycoproteins. Infectivity was increased by a factor of 1.6 to 2.3 for virions bearing on their surfaces host-derived HLA-DR1. The observed enhancement of HIV-1 infectivity was independent of the virus stocks used and was seen in several T-lymphoid cell lines, in a premonocytoid cell line, and in primary peripheral blood mononuclear cells. Finally, we determined that the presence of virion-bound cellular HLA-DR1 is associated with faster kinetics of virus infection. Taken together, these results suggest that HLA-DR-1-bearing HIV-1 particles had a greater infectivity per picogram of viral p24 protein than HLA-DR1-free virions. PMID:9032323

  19. The cometary H II regions of DR 21: Bow shocks or champagne flows or both?

    NASA Astrophysics Data System (ADS)

    Immer, K.; Cyganowski, C.; Reid, M. J.; Menten, K. M.

    2014-03-01

    We present deep Very Large Array H66α radio recombination line (RRL) observations of the two cometary H II regions in DR 21. With these sensitive data, we test the "hybrid" bow shock/champagne flow model previously proposed for the DR 21 H II regions. The ionized gas down the tail of the southern H II region is redshifted by up to ~30 km s-1 with respect to the ambient molecular gas, as expected in the hybrid scenario. The RRL velocity structure, however, reveals the presence of two velocity components in both the northern and southern H II regions. This suggests that the ionized gas is flowing along cone-like shells, swept-up by stellar winds. The observed velocity structure of the well-resolved southern H II region is most consistent with a picture that combines a stellar wind with stellar motion (as in bow shock models) along a density gradient (as in champagne flow models). The direction of the implied density gradient is consistent with that suggested by maps of dust continuum and molecular line emission in the DR 21 region. The image cubes are only available as a FITS file at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/563/A39Table 2, Fig. 4, and Appendices A and B are available in electronic form at http://www.aanda.org

  20. Epidermal HLA-DR and the enhancement of cutaneous reactivity to superantigenic toxins in psoriasis.

    PubMed

    Travers, J B; Hamid, Q A; Norris, D A; Kuhn, C; Giorno, R C; Schlievert, P M; Farmer, E R; Leung, D Y

    1999-11-01

    Streptococcal and staphylococcal superantigens (SAg's) have been implicated in the pathogenesis of inflammatory skin diseases, but the mechanisms by which these toxins act are unknown. The present study assessed the ability of nanogram quantities of topically applied purified toxic shock syndrome toxin-1 (TSST-1), staphylococcal enterotoxin type B, and streptococcal pyrogenic enterotoxin types A and C to induce inflammatory reactions in clinically uninvolved skin of normal controls and subjects with psoriasis, atopic dermatitis, and lichen planus. These SAg's triggered a significantly greater inflammatory skin response in psoriatics than in normal control subjects or in subjects with atopic dermatitis or lichen planus. Surprisingly, skin biopsies did not exhibit the T-cell receptor Vbeta stimulatory properties predicted for SAg-induced skin reactions. By 6 hours after patch testing with SAg's, TNF-alpha mRNA had increased in the epidermis (but not the dermis) in biopsies from psoriatics, compared with controls. Immunohistochemical studies revealed significantly higher HLA-DR expression in keratinocytes from psoriatics than from controls. However, a mutant TSST-1 protein that fails to bind HLA-DR did not elicit an inflammatory skin reaction. These results indicate that keratinocyte expression of HLA-DR enhances inflammatory skin responses to SAg's. They may also account for previous studies failing to demonstrate selective expansion of T-cell receptor Vbetas in psoriatics colonized with SAg-producing Staphylococcus aureus, and they identify a novel T cell-independent mechanism by which SAg's contribute to the pathogenesis of inflammatory skin diseases.

  1. Sputum eosinophils from asthmatics express ICAM-1 and HLA-DR.

    PubMed Central

    Hansel, T T; Braunstein, J B; Walker, C; Blaser, K; Bruijnzeel, P L; Virchow, J C; Virchow, C

    1991-01-01

    Sputum from symptomatic asthmatics is a rich source of eosinophils from the respiratory tract. Following liquefaction of sputum with dithioerythritol (DTE), a cell suspension for indirect double immunofluorescence with flow cytometry was obtained. Eosinophils were identified using anti-CD9 fluorescein conjugate, and particular surface markers measured with the relevant mouse MoAb followed by goat anti-mouse immunoglobulin phycoerythrin conjugate. Blood and sputum eosinophil surface markers were determined in parallel from asthmatics not receiving steroid therapy. Sputum eosinophils were found to have considerably elevated levels of CD11b, a reflection of eosinophil activation. Sputum but not blood eosinophils were found to express ICAM-1 (nine out of 11 cases) and HLA-DR (eight out of 11 cases). Furthermore, following culture of normal blood eosinophils with pooled T cell supernatants, ICAM-1 and HLA-DR could be induced in vitro. The induction of eosinophil adhesion molecules such as ICAM-1 and HLA-DR may influence eosinophil localization and function in asthma. PMID:1682072

  2. Expression of HLA-DR, CD80, and CD86 in Healthy Aging and Alzheimer's Disease.

    PubMed

    Busse, Stefan; Steiner, Johann; Alter, Juliane; Dobrowolny, Henrik; Mawrin, Christian; Bogerts, Bernhard; Hartig, Roland; Busse, Mandy

    2015-01-01

    Although monocytes and macrophages could serve as new therapeutic targets for treatment of Alzheimer's disease (AD) and aging of the human innate immune system, its role in the pathogenesis of neurodegenerative disorders such as AD are only poorly understood. We have addressed this here by determining the number of CD14+ monocytes and the frequency of HLA-DR-, CD80-, and CD86-expression in peripheral blood from healthy volunteers aged 20-79 years, and in AD patients at diagnosis and after 12, 30, and 52 weeks of rivastigmine treatment. While the number of CD14+ monocytes remained constant, the expression of HLA-DR, CD80, and CD86 by monocytes increased with age. However, no differences were identified by comparing AD patients with age-matched healthy controls or following treatment of AD patients with rivastigmine. These results indicate that changes in the expression of HLA-DR, CD80, and CD86 are caused by immunosenescence rather than by AD pathology or treatment of AD patients with rivastigmine.

  3. HLA-DR and -DQ eplet mismatches and transplant glomerulopathy: a nested case-control study.

    PubMed

    Sapir-Pichhadze, R; Tinckam, K; Quach, K; Logan, A G; Laupacis, A; John, R; Beyene, J; Kim, S J

    2015-01-01

    We conducted a nested case-control study from a cohort of adult kidney transplant recipients to assess the risk of transplant glomerulopathy (TG) as a function of donor and recipient HLA-DR and -DQ incompatibility at the eplet level. Cases (n = 52) were defined as patients diagnosed with transplant glomerulopathy based on biopsies showing glomerular basement membrane duplication without immune complex deposition. Controls (n = 104) with a similar follow-up from transplantation were randomly selected from the remaining cohort. HLAMatchmaker was used to ascertain the number of DRB1/3/4/5, DQA1 and DQB1 related eplet mismatches (eplet load). Multivariable conditional logistic regression models demonstrated an increase in the odds of TG (odds ratios [OR] of 2.84 [95% confidence interval (CI): 1.03, 7.84] and 4.62 [95% CI: 1.51, 14.14]) in the presence of 27-43 and >43 HLA-DR + DQ related eplet mismatches versus <27 eplet mismatches, respectively. When the eplet load was modeled as a continuous variable, the OR for TG was 1.25 (95% CI: 1.04, 1.50) for every 10 additional HLA-DR + DQ eplet mismatches. Our study suggests that minimization of HLA-DR + DQ eplet mismatches may decrease the incidence of transplant glomerulopathy diagnosed by indication biopsies. The role of eplet immunogenicity/antigenicity as determinants of allograft outcomes requires further study. PMID:25521856

  4. DR Tauri: Temporal variability of the brightness distribution in the potential planet-forming region

    NASA Astrophysics Data System (ADS)

    Brunngräber, R.; Wolf, S.; Ratzka, Th.; Ober, F.

    2016-01-01

    Aims: We investigate the variability of the brightness distribution and the changing density structure of the protoplanetary disk around DR Tau, a classical T Tauri star. DR Tau is known for its peculiar variations from the ultraviolet (UV) to the mid-infrared (MIR). Our goal is to constrain the temporal variation of the disk structure based on photometric and MIR interferometric data. Methods: We observed DR Tau with the MID-infrared Interferometric instrument (MIDI) at the Very Large Telescope Interferometer (VLTI) at three epochs separated by about nine years, two months, respectively. We fit the spectral energy distribution and the MIR visibilities with radiative transfer simulations. Results: We are able to reproduce the spectral energy distribution as well as the MIR visibility for one of the three epochs (third epoch) with a basic disk model. We were able to reproduce the very different visibility curve obtained nine years earlier with a very similar baseline (first epoch), using the same disk model with a smaller scale height. The same density distribution also reproduces the observation made with a higher spatial resolution in the second epoch, i.e. only two months before the third epoch. Based on observations collected at the European Organisation for Astronomical Research in the Southern Hemisphere, Chile, under the programs 074.C-0342(A) and 092.C-0726(A,B).

  5. A deletion mutant defines DQ beta variants with DR4 positive DQw3 positive haplotypes.

    PubMed

    Nepom, B S; Kim, S J; Nepom, G T

    1986-10-01

    We describe the production of an HLA deletion mutation by radiation mutagenesis of a DR4- and DQw3-homozygous, Dw4- and Dw14-heterozygous cell line designed to analyze polymorphisms associated with DR4 and DQw3. Southern blot analysis confirms a deletion of class I and class II genes on one haplotype. Variation in DQ beta alleles associated with DQw3 was previously described by characteristic RFLP patterns for a DQ beta bene. One pattern, which correlated precisely with A-10-83 monoclonal antibody reactivity (TA10), defined an allele which we call DQ"3.1". The mutant cell line has lost the polymorphic bands on Southern blots corresponding to the DQ"3.1" allele, while the intact Dw14 haplotype retains the alternate allele at DQ beta which is DQw-3 positive. TA10-negative. These data demonstrate the segregation of two DQw3 positive DQ beta allelic variants, both associated with DR4, which can be distinguished on the basis of both RFLP and monoclonal antibody reactivity. PMID:2875977

  6. Purification and characterization of DR_2577 (SlpA) a major S-layer protein from Deinococcus radiodurans

    SciTech Connect

    Farci, Domenica; Bowler, Matthew W.; Esposito, Francesca; McSweeney, Sean; Tramontano, Enzo; Piano, Dario

    2015-06-03

    The protein DR_2577 is a major Surface layer component of the radio-resistant bacterium Deinococcus radiodurans. In the present study DR_2577 has been purified and its oligomeric profile characterized by means of size exclusion chromatography and gel electrophoresis. DR_2577 was found to be organized into three hierarchical orders characterized by monomers, stable dimers formed by the occurrence of disulfide bonds, and hexamers resulting from a combination of dimers. Finally, the structural implications of these findings are discussed providing new elements for a more integrated model of this S-layer.

  7. The contribution of Dr. Mary Walker towards myasthenia gravis and periodic paralysis whilst working in poor law hospitals in London.

    PubMed

    Johnston, J D

    2005-06-01

    Dr. Mary Walker discovered in 1934 that physostigmine and Prostigmin temporarily restored muscle function in patients with myasthenia gravis. In the next five years, Dr. Walker and colleagues provided clinical evidence for the weakness of myasthenia gravis being caused by a "disturbance of transmission of excitation from motor nerve to voluntary muscle presumably caused by a deficiency of acetylcholine. Physostigmine (or Prostigmin) compensated for the lack of acetylcholine by delaying its destruction." Dr. Walker and colleagues also described the association between familial periodic paralysis and hypokalaemia.

  8. Purification and characterization of DR_2577 (SlpA) a major S-layer protein from Deinococcus radiodurans

    PubMed Central

    Farci, Domenica; Bowler, Matthew W.; Esposito, Francesca; McSweeney, Sean; Tramontano, Enzo; Piano, Dario

    2015-01-01

    The protein DR_2577 is a major Surface layer component of the radio-resistant bacterium Deinococcus radiodurans. In the present study DR_2577 has been purified and its oligomeric profile characterized by means of size exclusion chromatography and gel electrophoresis. DR_2577 was found to be organized into three hierarchical orders characterized by monomers, stable dimers formed by the occurrence of disulfide bonds, and hexamers resulting from a combination of dimers. The structural implications of these findings are discussed providing new elements for a more integrated model of this S-layer. PMID:26074883

  9. Purification and characterization of DR_2577 (SlpA) a major S-layer protein from Deinococcus radiodurans.

    PubMed

    Farci, Domenica; Bowler, Matthew W; Esposito, Francesca; McSweeney, Sean; Tramontano, Enzo; Piano, Dario

    2015-01-01

    The protein DR_2577 is a major Surface layer component of the radio-resistant bacterium Deinococcus radiodurans. In the present study DR_2577 has been purified and its oligomeric profile characterized by means of size exclusion chromatography and gel electrophoresis. DR_2577 was found to be organized into three hierarchical orders characterized by monomers, stable dimers formed by the occurrence of disulfide bonds, and hexamers resulting from a combination of dimers. The structural implications of these findings are discussed providing new elements for a more integrated model of this S-layer.

  10. Approach for Identifying Human Leukocyte Antigen (HLA)-DR Bound Peptides from Scarce Clinical Samples.

    PubMed

    Heyder, Tina; Kohler, Maxie; Tarasova, Nataliya K; Haag, Sabrina; Rutishauser, Dorothea; Rivera, Natalia V; Sandin, Charlotta; Mia, Sohel; Malmström, Vivianne; Wheelock, Åsa M; Wahlström, Jan; Holmdahl, Rikard; Eklund, Anders; Zubarev, Roman A; Grunewald, Johan; Ytterberg, A Jimmy

    2016-09-01

    Immune-mediated diseases strongly associating with human leukocyte antigen (HLA) alleles are likely linked to specific antigens. These antigens are presented to T cells in the form of peptides bound to HLA molecules on antigen presenting cells, e.g. dendritic cells, macrophages or B cells. The identification of HLA-DR-bound peptides presents a valuable tool to investigate the human immunopeptidome. The lung is likely a key player in the activation of potentially auto-aggressive T cells prior to entering target tissues and inducing autoimmune disease. This makes the lung of exceptional interest and presents an ideal paradigm to study the human immunopeptidome and to identify antigenic peptides.Our previous investigation of HLA-DR peptide presentation in the lung required high numbers of cells (800 × 10(6) bronchoalveolar lavage (BAL) cells). Because BAL from healthy nonsmokers typically contains 10-15 × 10(6) cells, there is a need for a highly sensitive approach to study immunopeptides in the lungs of individual patients and controls.In this work, we analyzed the HLA-DR immunopeptidome in the lung by an optimized methodology to identify HLA-DR-bound peptides from low cell numbers. We used an Epstein-Barr Virus (EBV) immortalized B cell line and bronchoalveolar lavage (BAL) cells obtained from patients with sarcoidosis, an inflammatory T cell driven disease mainly occurring in the lung. Specifically, membrane complexes were isolated prior to immunoprecipitation, eluted peptides were identified by nanoLC-MS/MS and processed using the in-house developed ClusterMHCII software. With the optimized procedure we were able to identify peptides from 10 × 10(6) cells, which on average correspond to 10.9 peptides/million cells in EBV-B cells and 9.4 peptides/million cells in BAL cells. This work presents an optimized approach designed to identify HLA-DR-bound peptides from low numbers of cells, enabling the investigation of the BAL immunopeptidome from individual patients

  11. HLA DR alloantigens in different subsets of patients with Sjögren's syndrome and in family members.

    PubMed Central

    Mann, D L; Moutsopoulos, H M

    1983-01-01

    Patients with Sjögren's syndrome alone (Ss), Sjögren's syndrome with rheumatoid arthritis (Ss-RA), and Sjögren's syndrome with Raynaud's phenomenon (Ss-RP) were typed for the HLA DR and MT antigens. Ss-RA patients had higher frequencies of HLA DR4 than did Ss patients. HLA-DR4 was also increased in frequency in patients with Ss-RP. This group of patients also showed increases in frequencies of HLA DR3. MT2 frequencies were elevated in all 3 patient groups, while MT1 was only increased in Ss. Three families with multiple individuals with Sjogren's syndrome were typed for HLA antigens. The affected individuals inherited unique combinations of haplotypes, suggesting the possibility of haplotype interaction in predisposition to disease. PMID:6605120

  12. HLA-DR-dependent variation of intrathecal IgG1 (Gm) allotype synthesis in multiple sclerosis.

    PubMed

    Salier, J P; Martin-Mondiere, C; Sesboüé, R; Daveau, M; Goust, J M; Govaerts, A; Schuller, E; Degos, J D

    1985-03-01

    Genetic susceptibility to multiple sclerosis (MS) in Caucasians was previously shown to be correlated to the presence of given alleles at the HLA-DR and Gm loci. We now demonstrate that the humoral immune response in MS central nervous system (CNS) is modulated by both loci: the levels of IgG1 subclass and IgG1 allotypes in cerebrospinal fluid of MS patients depend on both their Gm genotype and their HLA-DR2 or HLA-DR7 phenotype. That HLA-DR molecules may either participate in a preferential recruitment of IgG1 allotype-producing B cells in MS CNS or act after such a selective homing is discussed. These results demonstrate that both HLA and Gm loci are synergistically involved in the modulation of the humoral immune response. PMID:3855432

  13. Dr. George Koob: "Alcohol use disorders are a major problem …" | NIH MedlinePlus the Magazine

    MedlinePlus

    ... JavaScript on. Feature: Rethinking Drinking Dr. George Koob: "Alcohol use disorders are a major problem …" Past Issues / ... is Director of the NIH's National Institute on Alcohol Abuse and Alcoholism. A renowned expert on how ...

  14. Enhanced DR5 binding capacity of nanovectorized TRAIL compared to its cytotoxic version by affinity chromatography and molecular docking studies.

    PubMed

    Zakaria, Albatoul; Picaud, Fabien; Guillaume, Yves Claude; Gharbi, Tijani; Micheau, Olivier; Herlem, Guillaume

    2016-09-01

    Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis of cancer cells when bound to its cognate receptors, TRAIL-R1 and TRAIL-R2 (DR4 and DR5), without being toxic to healthy cells. Nanovectorized TRAIL (abbreviated as NPT) is 10 to 20 times more efficient than one of the most potent soluble TRAIL used in preclinical studies (His-TRAIL). To determine whether differences in affinity may account for NPT superiority, a thermodynamic study was undertaken to evaluate NPT versus TRAIL binding affinity to DR5. Docking calculations showed that TRAIL in homotrimer configuration was more stable than in heterotrimer, because of the presence of one Zn ion in its structure. Indeed, TRAIL trimers can have head-to-tail orientations when Zn is missing. Altogether these data suggest that TRAIL homotrimer structures are predominant in solution and then are grafted on NPT. When docked to DR5, NPT carrying TRAIL homotrimer leads to a more stable complex than TRAIL monomer-based NPT. To comfort these observations, the extracellular domain of DR5 was immobilized on a chromatographic support using an "in situ" immobilization technique. The determination of the thermodynamic data (enthalpy ∆H° and entropy ∆S°*) of TRAIL and NPT binding to DR5 showed that the binding mechanism was pH dependent. The affinity of NPT to DR5 increased with pH, and the ionized energy was more important for NPT than for soluble TRAIL. Moreover, because of negative values of ∆H° and ∆S°* quantities, we demonstrated that van der Waals and hydrogen bonds governed the strong NPT-DR5 association for pH > 7.4 (as for TRAIL alone). Copyright © 2016 John Wiley & Sons, Ltd. PMID:26952193

  15. NCI's Dr. Barry Kramer on C-SPAN Over-Diagnosis and Treatment of Cancer | Division of Cancer Prevention

    Cancer.gov

    Dr. Barnett Kramer on Over-Diagnosis and Treatment of Cancer. Dr. Barnett Kramer talked about a study published in the Journal of American Medical Association on the changing the definition of cancer that could reduce unnecessary treatments for benign cancers. He also responded to telephone calls and electronic communications. For more information view the full article at: C-SPAN |

  16. Molecular characterization by high-resolution isoelectric focusing of the products encoded by the class II region loci of the major histocompatibility complex in humans. I. DR and DQ gene variants.

    PubMed

    Rodriguez de Cordoba, S; Nunez-Roldan, A; Winchester, R; Marshall, P; Carrier, C; Mollen, N; Walker, M; Ginsberg-Fellner, F; Rubinstein, P

    1987-09-01

    We describe a new approach to the analysis of the structural polymorphism of the DR beta, DQ alpha, and DQ beta polypeptide chains of human histocompatibility class II antigens. In comparison to conventional two-dimensional gel studies, this method provides sharper definition of the protein bands and side-by-side comparisons within the same gel, thereby permitting the detection of minor differences in the isoelectric points of the protein chains. Using this methodology we have analyzed the IEF polymorphism and the variability in the number of the DR beta chains encoded by different DR haplotypes. Twenty DR beta chain variants, which include the products of no less than two separate DR beta loci, have been thus far identified. Alleles at one of these loci are assumed to code for DR beta chains carrying the DR alloespecificities DR1, DR2, DR3, DR4, DR5, DRw6, DR7, and DR8. Alleles at a second DR beta locus encode DR beta chains that may be shared by serologically DR-different haplotypes and carry supertypic serologic specificities (i.e., DRw52 and DRw53). We also demonstrate here that the structural polymorphisms of the DQ alpha and DQ beta chains are more extensive than previously thought, report the characterization of 14 DQ beta variants, and define their relationship to the previously described DQw serologic specificities. In addition, we describe the class II haplotype associations observed for the different DR and DQ variants characterized. PMID:3679903

  17. MSeqDR: A Centralized Knowledge Repository and Bioinformatics Web Resource to Facilitate Genomic Investigations in Mitochondrial Disease.

    PubMed

    Shen, Lishuang; Diroma, Maria Angela; Gonzalez, Michael; Navarro-Gomez, Daniel; Leipzig, Jeremy; Lott, Marie T; van Oven, Mannis; Wallace, Douglas C; Muraresku, Colleen Clarke; Zolkipli-Cunningham, Zarazuela; Chinnery, Patrick F; Attimonelli, Marcella; Zuchner, Stephan; Falk, Marni J; Gai, Xiaowu

    2016-06-01

    MSeqDR is the Mitochondrial Disease Sequence Data Resource, a centralized and comprehensive genome and phenome bioinformatics resource built by the mitochondrial disease community to facilitate clinical diagnosis and research investigations of individual patient phenotypes, genomes, genes, and variants. A central Web portal (https://mseqdr.org) integrates community knowledge from expert-curated databases with genomic and phenotype data shared by clinicians and researchers. MSeqDR also functions as a centralized application server for Web-based tools to analyze data across both mitochondrial and nuclear DNA, including investigator-driven whole exome or genome dataset analyses through MSeqDR-Genesis. MSeqDR-GBrowse genome browser supports interactive genomic data exploration and visualization with custom tracks relevant to mtDNA variation and mitochondrial disease. MSeqDR-LSDB is a locus-specific database that currently manages 178 mitochondrial diseases, 1,363 genes associated with mitochondrial biology or disease, and 3,711 pathogenic variants in those genes. MSeqDR Disease Portal allows hierarchical tree-style disease exploration to evaluate their unique descriptions, phenotypes, and causative variants. Automated genomic data submission tools are provided that capture ClinVar compliant variant annotations. PhenoTips will be used for phenotypic data submission on deidentified patients using human phenotype ontology terminology. The development of a dynamic informed patient consent process to guide data access is underway to realize the full potential of these resources.

  18. Filamentous hemagglutinin has a major role in mediating adherence of Bordetella pertussis to human WiDr cells.

    PubMed Central

    Urisu, A; Cowell, J L; Manclark, C R

    1986-01-01

    [35S]methionine-labeled Bordetella pertussis adhered to monolayers of WiDr cells, an epitheliumlike cell line from a human intestinal carcinoma. Adherence was proportional to the density of the WiDr cells and to the concentration of B. pertussis in the assay. Adherence of virulent phase I strains Tohama phase I, 114, and BP338 was much greater than adherence of avirulent strains Tohama phase III and 423 phase IV. Mutants deficient in the production of the filamentous hemagglutinin (FHA) were hemagglutination negative and adhered to WiDr cells much less efficiently than the parent strains. Preincubation of B. pertussis cells with FHA increased their hemagglutination activity and adherence to WiDr cells. Goat antibody to FHA inhibited, in a dose-dependent manner, the adherence of strain Tohama I but not the adherence of FHA-deficient mutant Tohama 325. At similar protein concentrations, normal goat antibody, goat antibody to pertussis toxin, or the Fab fragments of goat antibody to serotype 2 fimbriae had no effect on adherence. Also, an FHA-positive strain without fimbriae showed high adherence, while a fimbriated FHA-deficient mutant adhered poorly. Our data indicate that FHA plays a major role in adherence of B. pertussis to human WiDr cells. Fimbriae do not appear to mediate attachment of B. pertussis to WiDr cells. PMID:2872165

  19. Molecular cloning and functional characterization of a high-affinity zinc importer (DrZIP1) from zebrafish (Danio rerio).

    PubMed

    Qiu, Andong; Shayeghi, Majid; Hogstrand, Christer

    2005-06-15

    Zinc is a vital micronutrient to all organisms and a potential toxicant to aquatic animals. It is therefore of importance to understand the mechanism of zinc regulation. In the present study, we molecularly cloned and functionally characterized a zinc transporter of the SLC39A family [commonly referred to as the ZIP (Zrt- and Irt-related protein) family] from the gill of zebrafish (Danio rerio) (DrZIP1). DrZIP1 protein was found to localize at the plasma membrane and to function as a zinc uptake transporter when being expressed in either chinook salmon (Oncorhynchus tshawytscha) embryonic 214 cells or Xenopus laevis oocytes. In comparison with pufferfish transporter proteins (FrZIP2 and FrECaC) that are known to facilitate cellular zinc uptake, DrZIP1 appears to have high affinity to bind and transport zinc, suggesting that it maybe a high-affinity zinc uptake transporter (Km < 0.5 microM) in fish. Orthologues of DrZIP1 were also identified in both freshwater and seawater pufferfish (Tetraodon nigroviridis and Takifugu rubripes), indicating that these proteins may be functionally conserved among different fish species. DrZIP1 mRNA is expressed in all the tissues examined in the present study and thus DrZIP1 may be a constitutive zinc uptake transporter in many cell types of zebrafish.

  20. MSeqDR: A Centralized Knowledge Repository and Bioinformatics Web Resource to Facilitate Genomic Investigations in Mitochondrial Disease.

    PubMed

    Shen, Lishuang; Diroma, Maria Angela; Gonzalez, Michael; Navarro-Gomez, Daniel; Leipzig, Jeremy; Lott, Marie T; van Oven, Mannis; Wallace, Douglas C; Muraresku, Colleen Clarke; Zolkipli-Cunningham, Zarazuela; Chinnery, Patrick F; Attimonelli, Marcella; Zuchner, Stephan; Falk, Marni J; Gai, Xiaowu

    2016-06-01

    MSeqDR is the Mitochondrial Disease Sequence Data Resource, a centralized and comprehensive genome and phenome bioinformatics resource built by the mitochondrial disease community to facilitate clinical diagnosis and research investigations of individual patient phenotypes, genomes, genes, and variants. A central Web portal (https://mseqdr.org) integrates community knowledge from expert-curated databases with genomic and phenotype data shared by clinicians and researchers. MSeqDR also functions as a centralized application server for Web-based tools to analyze data across both mitochondrial and nuclear DNA, including investigator-driven whole exome or genome dataset analyses through MSeqDR-Genesis. MSeqDR-GBrowse genome browser supports interactive genomic data exploration and visualization with custom tracks relevant to mtDNA variation and mitochondrial disease. MSeqDR-LSDB is a locus-specific database that currently manages 178 mitochondrial diseases, 1,363 genes associated with mitochondrial biology or disease, and 3,711 pathogenic variants in those genes. MSeqDR Disease Portal allows hierarchical tree-style disease exploration to evaluate their unique descriptions, phenotypes, and causative variants. Automated genomic data submission tools are provided that capture ClinVar compliant variant annotations. PhenoTips will be used for phenotypic data submission on deidentified patients using human phenotype ontology terminology. The development of a dynamic informed patient consent process to guide data access is underway to realize the full potential of these resources. PMID:26919060

  1. Studying the biology of hope: An interview with Lee S. Berk, DrPH, MPH. Interview by Sheldon Lewis.

    PubMed

    Berk, Lee S

    2007-01-01

    Dr Lee S. Berk is a pioneering medical researcher studying the neuroendocrine and immune effects of positive emotions. He is an associate professor of Health Promotion and Education, School of Public Health, and associate research professor of Pathology and Human Anatomy, School of Medicine, both at Loma Linda University in Loma Linda, California. Dr Berk is a fellow of the American College of Sports Medicine and the American Association for Integrative Medicine. He is also nationally board certified as a health education specialist and has served as a member of the board of directors for the American College of Lifestyle Medicine in Loma Linda, California. Dr Berk is a member of the editorial board of Advances in Mind Body Medicine. During the Society for Neurosciences' annual 2001 meeting Dr Berk presented and received major media coverage of a landmark paper entitled, "The Anticipation of a Laughter Eustress Event Modulates Mood States Prior to the Actual Humor Experience." More recently Dr Berk presented at the FASEB (Federation of American Societies for Experimental Biology) annual 2006 meeting in the American Physiological Society section another landmark paper entitled, "Beta-Endorphin and HGH Increase are Associated With Both the Anticipation and Experience of Mirthful Laughter," with further major media coverage. Recently, Dr Berk spoke about his work with Sheldon Lewis, editor in chief of Advances.

  2. HLA-DQ rather than HLA-DR region might be involved in dominant nonsusceptibility to diabetes.

    PubMed Central

    Sterkers, G; Zeliszewski, D; Chaussée, A M; Deschamps, I; Font, M P; Freidel, C; Hors, J; Betuel, H; Dausset, J; Levy, J P

    1988-01-01

    Since HLA-DRw15 (a subdivision of the HLA-DR2 specificity previously called DR2 long) is associated with dominant nonsusceptibility to insulin-dependent diabetes mellitus (IDDM), while HLA-DRw16 (another subdivision of HLA-DR2, previously called DR2 short) is positively associated with the disease, we looked for particular characteristics of HLA products encoded by the DR2 haplotypes of IDDM patients. The results show the following: (i) HLA-DQ molecules of HLA-DRw15-positive IDDM patients are different from those of HLA-DRw15-positive controls, suggesting that the HLA-DQ gene of DRw15 haplotypes is involved in a protective effect. (ii) HLA-DR and -DQ products of DRw16-positive IDDM are functionally indistinguishable from those of HLA-DRw16-positive controls. Furthermore, our data provide evidence that the residue at position 57 on the DQ beta chain could play a crucial biological role in antigen presentation to T cells as far as the DRw16 haplotype is concerned. This observation fits with the recent observation of correlation between DQ beta allelic polymorphism at position 57 and both susceptibility and resistance to IDDM. PMID:2901099

  3. Enrique: A case study of a gifted computer user

    SciTech Connect

    Sesko, S C

    2000-03-17

    The author has been investigating the affective and intellectual views that gifted children have about computers. These studies have used various methodological approaches in order to develop a broad perspective on the issues involved in this topic. The author has used survey instruments (Sesko, 1998) and interview techniques (Sesko, 1999) to capture both statistical and narrative data. The objective of this study is to explore in depth the interactions that one student has with the machine and its applications. The driver for this and the previous studies was the paucity of research in the area of gifted and talented children and their involvement with what has become the primary intellectual tool of the century (Turkel, 1984). The second reason is that it has been posited that the intellectual characteristics of gifted children should enable those who are interested in computers to achieve a high level of proficiency with either computer applications or programming. Further, the ability to learn things at a young age should allow gifted children who use computers to develop a large variety of computer-based activities. The author has shown evidence to support these ideas in previous work. Finally, as Hausman (1985) claims, facilities with computers should allow these children to create new activities for using computers. The author found no published research to demonstrate whether they do; but still believes the results of this case study strongly support Hausman's contentions.

  4. Compressor Calorimeter Test of R-410A Alternatives R-32, DR-5, and L-41a

    SciTech Connect

    Shrestha, Som S; Mahderekal, Isaac; Sharma, Vishaldeep; Abdelaziz, Omar

    2013-02-01

    As a contribution to the AHRI Low-GWP Alternative Refrigerants Evaluation Program (AREP), this study compares performance of alternative refrigerants R32, DR-5, and L-41A to that of refrigerant R-410A (baseline) in a scroll compressor designed for air-conditioning and heat pump applications. Compressor calorimeter tests were performed to evaluate the performance of the lower-GWP alternative refrigerants in place of the common refrigerant R-410A in a 36,000 Btu/hr compressor calorimeter using a compressor having a nominal rated capacity of 21,300 Btu/hr. Tests were conducted over a suction dew point temperature range of 10 F to 55 F in 5 F increments and a discharge dew point temperature range of 70 F to 140 F in 10 F increments. All the tests were performed with 20 F superheat, 40 F superheat and 65 F suction temperature. A liquid subcooling level of 15 F was maintained for all the test conditions. The tests showed that performance of these three lower-GWP alternative refrigerants is comparable to that of R-410A. For the 20 F superheat and 15 F subcooling test conditions, EERs of R32, DR-5, and L-41A were 90% to 99%, 96% to 99%, and 94% to 101%, respectively, compared to that of R-410A. Similarly, cooling capacities of R32, DR-5, and L-41A were 98% to 103%, 92% to 96%, and 84% to 92%, respectively, compared to that of R-410A.

  5. Evaluation of the pDR-1200 real-time aerosol monitor.

    PubMed

    Benton-Vitz, Kaila; Volckens, John

    2008-06-01

    The objective of this research was to characterize the ability of the pDR-1200 real-time aerosol monitor to measure aerosols of varying size, composition, and origin. Particle aspiration and transmission efficiency was characterized at airflow rates of 2 L/min, 5 L/min, and 10 L/min in a wind tunnel in both static and orientation-averaged configurations. At 10 L/min, the particle cut point for 50% penetration of particles through the device (d(50)) was approximately 6 micro m, while at 2 L/min and 5 L/min the d(50) was significantly larger, about 9 micro m (p = 0.01). There was no significant difference in particle penetration efficiency between facing-the-wind and orientation-averaged configurations (p(avg) = 0.66). The pDR-1200 response factor, which is defined as the ratio the time-averaged, monitor-reported concentration to a gravimetric filter concentration measured directly downstream of the sensing zone, was evaluated for four aerosol types: Arizona road dust, background ambient aerosol, environmental tobacco smoke, and diesel particulate matter. These aerosols, each of varying refractive index and particle size distribution, produced significant changes in the measured response factor (p < 0.01). The pDR-1200 both overestimated and underestimated (up to a factor of 7) the gravimetrically determined aerosol concentration. These discrepancies further reinforce the need to calibrate the instrument in situ for each aerosol of interest. Inter-instrument variability was generally low for co-located monitors.

  6. A two-plasmid Escherichia coli system for expression of Dr adhesins.

    PubMed

    Kur, Marta; Piatek, Rafał; Kur, Józef

    2007-10-01

    This paper presents a very efficient expression system for production of Dr adhesins. The system consists of two plasmids. One is the pACYCpBAD-DraC-C-His, which contains the draC gene under the control of the arabinose promoter (pBAD), encoding the DraC usher. The second is the pET30b-syg-DraBE, which contains the draB and draE genes under the control of the T7lac promoter, encoding the DraB chaperone and the DraE adhesin, respectively. Those plasmids have different origin of replication and can therefore coexist in one cell. Since different promoters are present, the protein expression can be controlled. The Dr adhesion expression system constructed opens up a lot of possibilities, and could be very useful in experiments focusing on understanding the biogenesis of Gram-negative bacteria adhesins. For this purpose we showed that the AfaE-III adhesin (98.1% identity between the DraE and the AfaE-III adhesins, with three divergent amino acids within the sequences) was able to pass through the DraC channel in the Escherichia coli BL21(DE3) strain. Immunoblotting analysis and immunofluorescence microscopy showed the presence of AfaE-III on the bacterial cell surface. In addition, the system described can be useful for displaying the immune-relevant sectors of foreign proteins on the bacterial cell. The heterologous epitope sequence of the HSV1 glycoprotein D was inserted into the draE gene in place of the N-terminal region of surface exposed domain 2. Chimeric proteins were exposed on the bacterial surface as evidenced by immunoblotting and immunofluorescence microscopy. The effective display of peptide segments on Dr fimbriae expressed at the bacterial cell surface, can be used for the development of a fimbrial vaccine.

  7. Engineering Synthetic Multistress Tolerance in Escherichia coli by Using a Deinococcal Response Regulator, DR1558

    PubMed Central

    Appukuttan, Deepti; Singh, Harinder; Park, Sun-Ha; Jung, Jong-Hyun; Jeong, Sunwook; Seo, Ho Seong; Choi, Yong Jun

    2015-01-01

    Cellular robustness is an important trait for industrial microbes, because the microbial strains are exposed to a multitude of different stresses during industrial processes, such as fermentation. Thus, engineering robustness in an organism in order to push the strains toward maximizing yield has become a significant topic of research. We introduced the deinococcal response regulator DR1558 into Escherichia coli (strain Ec-1558), thereby conferring tolerance to hydrogen peroxide (H2O2). The reactive oxygen species (ROS) level in strain Ec-1558 was reduced due to the increased KatE catalase activity. Among four regulators of the oxidative-stress response, OxyR, RpoS, SoxS, and Fur, we found that the expression of rpoS increased in Ec-1558, and we confirmed this increase by Western blot analysis. Electrophoretic mobility shift assays showed that DR1558 bound to the rpoS promoter. Because the alternative sigma factor RpoS regulates various stress resistance-related genes, we performed stress survival analysis using an rpoS mutant strain. Ec-1558 was able to tolerate a low pH, a high temperature, and high NaCl concentrations in addition to H2O2, and the multistress tolerance phenotype disappeared in the absence of rpoS. Microarray analysis clearly showed that a variety of stress-responsive genes that are directly or indirectly controlled by RpoS were upregulated in strain Ec-1558. These findings, taken together, indicate that the multistress tolerance conferred by DR1558 is likely routed through RpoS. In the present study, we propose a novel strategy of employing an exogenous response regulator from polyextremophiles for strain improvement. PMID:26655758

  8. DR4 specific TRAIL variants are more efficacious than wild-type TRAIL in pancreatic cancer.

    PubMed

    Yu, Rui; Albarenque, Stella Maris; Cool, Robbert H; Quax, Wim J; Mohr, Andrea; Zwacka, Ralf M

    2014-01-01

    Current treatment modalities for pancreatic carcinoma afford only modest survival benefits. TRAIL, as a potent and specific inducer of apoptosis in cancer cells, would be a promising new treatment option. However, since not all pancreatic cancer cells respond to TRAIL, further improvements and optimizations are still needed. One strategy to improve the effectiveness of TRAIL-based therapies is to specifically target one of the 2 cell death inducing TRAIL-receptors, TRAIL-R1 or TRAIL-R2 to overcome resistance. To this end, we designed constructs expressing soluble TRAIL (sTRAIL) variants that were rendered specific for either TRAIL-R1 or TRAIL-R2 by amino acid changes in the TRAIL ectodomain. When we expressed these constructs, including wild-type sTRAIL (sTRAIL(wt)), TRAIL-R1 (sTRAIL(DR4)) and TRAIL-R2 (sTRAIL(DR5)) specific variants, in 293 producer cells we found all to be readily expressed and secreted into the supernatant. These supernatants were subsequently transferred onto target cancer cells and apoptosis measured. We found that the TRAIL-R1 specific variant had higher apoptosis-inducing activity in human pancreatic carcinoma Colo357 cells as well as PancTu1 cells that were additionally sensitized by targeting of XIAP. Finally, we tested TRAIL-R1 specific recombinant TRAIL protein (rTRAIL(DR4)) on Colo357 xenografts in nude mice and found them to be more efficacious than rTRAIL(wt). Our results demonstrate the benefits of synthetic biological approaches and show that TRAIL-R1 specific variants can potentially enhance the therapeutic efficacy of TRAIL-based therapies in pancreatic cancer, suggesting that they can possibly become part of individualized and tumor specific combination treatments in the future. PMID:25482930

  9. Engineering Synthetic Multistress Tolerance in Escherichia coli by Using a Deinococcal Response Regulator, DR1558.

    PubMed

    Appukuttan, Deepti; Singh, Harinder; Park, Sun-Ha; Jung, Jong-Hyun; Jeong, Sunwook; Seo, Ho Seong; Choi, Yong Jun; Lim, Sangyong

    2016-02-01

    Cellular robustness is an important trait for industrial microbes, because the microbial strains are exposed to a multitude of different stresses during industrial processes, such as fermentation. Thus, engineering robustness in an organism in order to push the strains toward maximizing yield has become a significant topic of research. We introduced the deinococcal response regulator DR1558 into Escherichia coli (strain Ec-1558), thereby conferring tolerance to hydrogen peroxide (H2O2). The reactive oxygen species (ROS) level in strain Ec-1558 was reduced due to the increased KatE catalase activity. Among four regulators of the oxidative-stress response, OxyR, RpoS, SoxS, and Fur, we found that the expression of rpoS increased in Ec-1558, and we confirmed this increase by Western blot analysis. Electrophoretic mobility shift assays showed that DR1558 bound to the rpoS promoter. Because the alternative sigma factor RpoS regulates various stress resistance-related genes, we performed stress survival analysis using an rpoS mutant strain. Ec-1558 was able to tolerate a low pH, a high temperature, and high NaCl concentrations in addition to H2O2, and the multistress tolerance phenotype disappeared in the absence of rpoS. Microarray analysis clearly showed that a variety of stress-responsive genes that are directly or indirectly controlled by RpoS were upregulated in strain Ec-1558. These findings, taken together, indicate that the multistress tolerance conferred by DR1558 is likely routed through RpoS. In the present study, we propose a novel strategy of employing an exogenous response regulator from polyextremophiles for strain improvement. PMID:26655758

  10. Healing bodies or saving souls? Reverend Dr Peter Parker (1804-1888) as medical missionary.

    PubMed

    Fu, Louis

    2016-05-01

    The important role played by medical services in the preaching of the Gospel in China was undeniable. Anglo-American missionaries entered Canton in the early 18th century and introduced modern Western medicine to China. Reverend Dr Peter Parker, founder of medical missionaries to China, was more than that, far more advanced than his predecessors including Drs Pearson, Livingstone and Colledge. He was an enthusiastic missionary of exceptional ability and vigour as witnessed his labours at the Canton Ophthalmic Hospital. His 20 years in the medical field unexpectedly paved the way for his future career as a diplomat in the American Legation. PMID:24833546

  11. Food and the purification of society: Dr. Paul Carton and vegetarianism in interwar France.

    PubMed

    Ouedraogo, A P

    2001-08-01

    This article examines the life and work of Dr Paul Carton (1875-1947), a French physician who promoted 'naturist vegetarianism". His career and the evolution of his ideas were influenced by his own experience as a young man of treatment for tuberculosis, and by an anti-materialist philosophy. He developed a diet for his patients that became influential through his writings and through the activities of the French Naturist Society. Although by no means the only advocate of such ideas, Carton's influence has survived and can still be discerned in a close reading of the present-day French popular press.

  12. [Dr. Ramón Pérez Cirera: Importance of his trajectory in Mexican pharmacology].

    PubMed

    López-Vega, Diana Laura; Martínez-Barbosa, Xóchitl

    2016-01-01

    Dr. Ramón Pérez Cirera (1936-1982) arrived in Mexico from Spain in 1936. Since then, his links with compatriots abroad and their acquired preparation in Europe allows to contribute to Mexican Pharmacology. He participated in teaching and research; he formalized, presided and helped to structure the Department of Pharmacology of the Faculty of Medicine from the National Autonomous University of Mexico and promoted the training of specialized associations. He led the Section of Pharmacology in the National Academy of Medicine. Understanding the value of his contribution helps to visualize the growth and maturation of national Pharmacology.

  13. Healing bodies or saving souls? Reverend Dr Peter Parker (1804-1888) as medical missionary.

    PubMed

    Fu, Louis

    2016-05-01

    The important role played by medical services in the preaching of the Gospel in China was undeniable. Anglo-American missionaries entered Canton in the early 18th century and introduced modern Western medicine to China. Reverend Dr Peter Parker, founder of medical missionaries to China, was more than that, far more advanced than his predecessors including Drs Pearson, Livingstone and Colledge. He was an enthusiastic missionary of exceptional ability and vigour as witnessed his labours at the Canton Ophthalmic Hospital. His 20 years in the medical field unexpectedly paved the way for his future career as a diplomat in the American Legation.

  14. Barremian decapod crustaceans from Serre de Bleyton (Drôme, SE France)

    PubMed Central

    Hyžný, Matúš; Kroh, Andreas

    2015-01-01

    Based on mostly small-sized isolated cheliped fingers, a new decapod crustacean assemblage is described from the Barremian of Serre de Bleyton (Drôme, SE France). The assemblage is composed mostly of representatives of the crab family Dynomenidae. In addition, remains of astacidean lobsters, axiidean shrimps, paguroid hermit crabs and brachyurous crabs of the families Necrocarcinidae and ?Cenomanocarcinidae occur in low numbers. Graptocarcinus moosleitneri (Dynomenidae) and ?Paranecrocarcinus schloegli (Necrocarcinidae) are introduced as new species. They both exhibit presence of multi-setal pores on dactyli that are interpreted as parts of a sieving mechanism used in feeding. The stratigraphic range of Graptocarcinus is extended herein to the Barremian. PMID:26097276

  15. Memorial tribute to astrobiology pioneers Dr. David S. Mckay and academician Georgy A. Zavarzin

    NASA Astrophysics Data System (ADS)

    Rozanov, Alexei Y.; Rozhnov, Sergei V.; Pikuta, Elena V.; Hoover, Richard B.

    2013-09-01

    During the past two years, the world has lost two great pioneers of the field of Astrobiology-Dr. David Stewart McKay who worked at the NASA-Johnson Space Center in Houston, Texas, USA and Academician Georgy Alexandrovich Zavarzin of the Institute of Microbiology of the Russian Academy of Sciences and Professor of the Moscow State University in Moscow, Russia. The Volume of the Proceedings of the 2013 SPIE Instruments, Methods, and Missions for Astrobiology XVI is dedicated to the memory of these great scientists. We remember our dear friends and review some of their many important contributions to Planetary Science, Geology, Meteoritics, Microbiology and Astrobiology.

  16. The 'Prof. Dr. Rómulo Lambre' Collection: an Argentinian sample of modern skeletons.

    PubMed

    Salceda, S A; Desántolo, B; Mancuso, R García; Plischuk, M; Inda, A M

    2012-08-01

    This paper describes the 'Prof. Dr. Rómulo Lambre' skeletal collection. The Lambre Collection is housed in the School of Medical Sciences of the National University of La Plata and it consists of skeletal remains ceded by the Municipal Cemetery of La Plata. The collection has more than four hundred skeletons, with information on age, sex, nationality, date and cause of death. It was created for teaching and research purposes in compliance with current legislation, and its management meets guidelines specified in the Declaration of the Argentinian Association for Biological Anthropology on Research Ethics on Human Remains (2007).

  17. The dragonfly's face of the multidimensional Dr. Angelo Barbosa Monteiro Machado: a short bio-bibliography.

    PubMed

    Pinto, Ângelo Parise

    2016-02-09

    In this special issue celebrating the Brazilian researcher Dr. Angelo Barbosa Monteiro Machado's 80th birthday, I present a very short biographical overview focused on his prolific career as odonatologist. The doctor, professor, children's book writer, conservationist, comedian, neuroanatomist, and eventually odonatologist Professor Angelo has published more than 110 papers, of which 79 are on dragonflies. He erected 97 new names, an impressive number for a small and relatively well-known order of insects. Here are presented annotated checklists of his publications on dragonflies (from 1953 to September of 2015), and nomina, as well as few comments of his impact on Neotropical odonatology as a whole.

  18. [Dr. Ramón Pérez Cirera: Importance of his trajectory in Mexican pharmacology].

    PubMed

    López-Vega, Diana Laura; Martínez-Barbosa, Xóchitl

    2016-01-01

    Dr. Ramón Pérez Cirera (1936-1982) arrived in Mexico from Spain in 1936. Since then, his links with compatriots abroad and their acquired preparation in Europe allows to contribute to Mexican Pharmacology. He participated in teaching and research; he formalized, presided and helped to structure the Department of Pharmacology of the Faculty of Medicine from the National Autonomous University of Mexico and promoted the training of specialized associations. He led the Section of Pharmacology in the National Academy of Medicine. Understanding the value of his contribution helps to visualize the growth and maturation of national Pharmacology. PMID:27595261

  19. Dr Syntax's view of Edinburgh medicine: the life and pictures of John Sheriff (1775-1844).

    PubMed

    Kennaway, J

    2015-01-01

    From the 1820s to the 1840s, one of the most recognisable figures in Edinburgh was the eccentric John Sheriff, generally known as Dr Syntax. He was a talented amateur artist, whose work provides a fascinating and strange insight into the mind of a troubled man and, because of his interest in medicine, into the history of medicine in Scotland at the time. This paper seeks to show that Sheriff and his pictures deserve to be remembered, since they offer intriguing insights for anyone interested in the history of medicine and of Edinburgh at the end of its Golden Age. PMID:27070894

  20. The dragonfly's face of the multidimensional Dr. Angelo Barbosa Monteiro Machado: a short bio-bibliography.

    PubMed

    Pinto, Ângelo Parise

    2016-01-01

    In this special issue celebrating the Brazilian researcher Dr. Angelo Barbosa Monteiro Machado's 80th birthday, I present a very short biographical overview focused on his prolific career as odonatologist. The doctor, professor, children's book writer, conservationist, comedian, neuroanatomist, and eventually odonatologist Professor Angelo has published more than 110 papers, of which 79 are on dragonflies. He erected 97 new names, an impressive number for a small and relatively well-known order of insects. Here are presented annotated checklists of his publications on dragonflies (from 1953 to September of 2015), and nomina, as well as few comments of his impact on Neotropical odonatology as a whole. PMID:27395960

  1. Dr. David Brown poses with students at Ronald McNair Middle School

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. David Brown (right), a NASA astronaut, poses with students in the gymnasium of Ronald McNair Magnet School in Cocoa, Fla. From left, the students are Kristin Rexford, Danitra Anderson, Dominique Smith, Fallon Davis, and Qiana Taylor. Brown was at the school to attend a tribute to NASA astronaut Ronald McNair. The school had previously been renamed for the fallen astronaut who was one of a crew of seven, who lost their lives during an accident following launch of the Space Shuttle Challenger in January 1986.

  2. Dr Charles Thomas Jackson's (1805-80) life after death: the 20th century mythology.

    PubMed

    Patterson, Richard

    2007-08-01

    References to Dr Charles Thomas Jackson in 20th century anaesthesia literature and biographical dictionaries and encyclopedias emphasize his maniacal insanity and its relation to his usurpations of the discoveries of others, including the controversy with William TG Morton concerning the honour of the discovery of surgical anaesthesia. In 1873, seven years before his death, he experienced sudden collapse and paralysis requiring hospitalization. Seminal 19th century brain research before his hospitalization correlated the signs and symptoms of his illness with pathology found at his autopsy.

  3. Mind, brain, body, and soul: a review of the electrophysiological undercurrents for Dr. Frankenstein.

    PubMed

    Kaplan, Peter W

    2004-01-01

    Mary Shelley's Frankenstein is perhaps the most famous work of medical science fiction. She and her husband, the poet Percy Shelley, were aware of nascent neuroscience experimentation and the effects of electricity on neuromuscular function. Such experiments generated theories of voluntary, involuntary, and unconscious neuromuscular function; animal electricity; and the anima--the human vital principle. In Germany and Italy, investigators were performing bizarre electrical experiments on animals and humans to "reanimate" lifeless limbs and bodies. These demonstrations and theories find expression in Frankenstein and provide models for Dr. Frankenstein and his creation.

  4. HLA-DR-DQ haplotypes and genotypes in Finnish patients with rheumatoid arthritis

    PubMed Central

    Laivoranta-Nyman, S; Mottonen, T; Hermann, R; Tuokko, J; Luukkainen, R; Hakala, M; Hannonen, P; Korpela, M; Yli-Kerttula, U; Toivanen, A; Ilonen, J; t and

    2004-01-01

    Objectives: To elucidate the contribution of HLA-DR-DQ haplotypes and their genotypic combinations to susceptibility to rheumatoid arthritis, and to evaluate the various models for HLA associated risk for the disease in a series of Finnish patients. Methods: 322 Finnish patients with rheumatoid arthritis were typed for common north European HLA-DR-DQ haplotypes and compared with a series of 1244 artificial family based control haplotypes. Results: The association of the so called shared epitope (SE) haplotypes (DRB1*0401, *0404, *0408, and *01) with rheumatoid arthritis was confirmed. The DRB1*0401 haplotypes carried a far stronger risk for the disease than the (DRB1*01/10)-(DQA1*01)-DQB1*0501 haplotypes. Seven protective HLA haplotypes—(DRB1*15)-(DQA1*01)-DQB1*0602; (DRB1*08)-(DQA1*04)-DQB1*04; (DRB1*11/12)-DQA1*05-DQB1*0301; (DRB1*1301)-(DQA1*01)-DQB1*0603; (DRB1*1302)-(DQA1*01)-DQB1*0604; (DRB1*07)-DQA1*0201-DQB1*0303; and (DRB1*16)- (DQA1*01)-DQB1*0502—were identified. In accordance with the reshaped shared epitope hypothesis, all the protective DRB1 alleles in these haplotypes share either isoleucine at position 67 or aspartic acid at position 70 in their third hypervariable region motif. However, differences in the disease risk of haplotypes carrying the same DR but different DQ alleles were also found: (DRB1*07)-DQA1*0201-DQB1*0303 was protective, while (DRB1*07)-DQA1*0201-DQB1*02 was neutral. The same haplotypes carried different risks for rheumatoid arthritis depending on their combination in genotypes. Conclusions: When assessing the influence of HLA genes on the susceptibility to rheumatoid arthritis, not only should the HLA-DR or -DQ alleles or haplotypes be unravelled but also the genotype. The effect of HLA class II region genes is more complicated than any of the existing hypotheses can explain. PMID:15479890

  5. [Dr. Juan Ramon Beltran and his contribution to the School of Dentistry].

    PubMed

    Zarranz, A

    1999-01-01

    He was in charge of the course of Legal Dentistry at the School of Dentistry from 1929 through 1932. He prepared the study program for this subject, basing it on the experience he had gained as professor in Legal Medicine at the Faculty of Medical Sciences in Buenos Aires. He published the book "Medicina Legal para la ensenanza de la Odontologia Legal y Social" (1932), and its second edition included an important contribution made by Dr. Juan Ubaldo Carrea, Main Professor of Orthodontics with Legal Dentistry at this school

  6. A Crusade Against Scorpion Sting: Life and Works of Dr. Himmatrao Bawaskar

    PubMed Central

    Kale, Ajinkya A.

    2012-01-01

    In the times of rapid advancement of science and technology, advance medical equipment and hi tech hospitals represent the face of medical science. The aspirations and ambitions of medical professionals are also shifting, with growing concerns of deterioration of doctor patient relationship as well as disconnect between services and the community needs. The life of Dr Himmatrao Bawaskar defies several conventions of today's medical practice. His outstanding dedication towards patients and commitment to provide high quality care in resource poor setting makes him an ideal role model for younger generation of physicians in India. PMID:24479002

  7. Peptides presented by HLA-DR molecules in synovia of patients with rheumatoid arthritis or antibiotic-refractory Lyme arthritis.

    PubMed

    Seward, Robert J; Drouin, Elise E; Steere, Allen C; Costello, Catherine E

    2011-03-01

    Disease-associated HLA-DR molecules, which may present autoantigens, constitute the greatest genetic risk factor for rheumatoid arthritis (RA) and antibiotic-refractory Lyme arthritis (LA). The peptides presented by HLA-DR molecules in synovia have not previously been defined. Using tandem mass spectrometry, rigorous database searches, and manual spectral interpretation, we identified 1,427 HLA-DR-presented peptides (220-464 per patient) from the synovia of four patients, two diagnosed with RA and two diagnosed with LA. The peptides were derived from 166 source proteins, including a wide range of intracellular and plasma proteins. A few epitopes were found only in RA or LA patients. However, two patients with different diseases who had the same HLA allele had the largest number of epitopes in common. In one RA patient, peptides were identified as originating from source proteins that have been reported to undergo citrullination under other circumstances, yet neither this post-translational modification nor anti-cyclic citrullinated peptide antibodies were detected. Instead, peptides with the post-translational modification of S-cysteinylation were identified. We conclude that a wide range of proteins enter the HLA-DR pathway of antigen-presenting cells in the patients' synovial tissue, and their HLA-DR genotype, not the disease type, appears to be the primary determinant of their HLA-DR-peptide repertoire. New insights into the naturally presented HLA-DR epitope repertoire in target tissues may allow the identification of pathogenic T cell epitopes, and this could lead to innovative therapeutic interventions.

  8. Peptides Presented by HLA-DR Molecules in Synovia of Patients with Rheumatoid Arthritis or Antibiotic-Refractory Lyme Arthritis*

    PubMed Central

    Seward, Robert J.; Drouin, Elise E.; Steere, Allen C.; Costello, Catherine E.

    2011-01-01

    Disease-associated HLA-DR molecules, which may present autoantigens, constitute the greatest genetic risk factor for rheumatoid arthritis (RA) and antibiotic-refractory Lyme arthritis (LA). The peptides presented by HLA-DR molecules in synovia have not previously been defined. Using tandem mass spectrometry, rigorous database searches, and manual spectral interpretation, we identified 1,427 HLA-DR-presented peptides (220–464 per patient) from the synovia of four patients, two diagnosed with RA and two diagnosed with LA. The peptides were derived from 166 source proteins, including a wide range of intracellular and plasma proteins. A few epitopes were found only in RA or LA patients. However, two patients with different diseases who had the same HLA allele had the largest number of epitopes in common. In one RA patient, peptides were identified as originating from source proteins that have been reported to undergo citrullination under other circumstances, yet neither this post-translational modification nor anti-cyclic citrullinated peptide antibodies were detected. Instead, peptides with the post-translational modification of S-cysteinylation were identified. We conclude that a wide range of proteins enter the HLA-DR pathway of antigen-presenting cells in the patients' synovial tissue, and their HLA-DR genotype, not the disease type, appears to be the primary determinant of their HLA-DR-peptide repertoire. New insights into the naturally presented HLA-DR epitope repertoire in target tissues may allow the identification of pathogenic T cell epitopes, and this could lead to innovative therapeutic interventions. PMID:21081667

  9. Direct ex vivo detection of HLA-DR3-restricted cytomegalovirus- and Mycobacterium tuberculosis-specific CD4+ T cells.

    PubMed

    Bronke, Corine; Palmer, Nanette M; Westerlaken, Geertje H A; Toebes, Mireille; van Schijndel, Gijs M W; Purwaha, Veenu; van Meijgaarden, Krista E; Schumacher, Ton N M; van Baarle, Debbie; Tesselaar, Kiki; Geluk, Annemieke

    2005-09-01

    In order to detect epitope-specific CD4+ T cells in mycobacterial or viral infections in the context of human class II major histocompatibility complex protein human leukocyte antigen (HLA)-DR3, two HLA-DR3 tetrameric molecules were successfully produced. One contained an immunodominant HLA-DR3-restricted T-cell epitope derived from the 65-kDa heat-shock protein of Mycobacterium tuberculosis, peptide 1-13. For the other tetramer, we used an HLA-DR3-restricted T-cell epitope derived from cytomegalovirus (CMV) pp65 lower matrix protein, peptide 510-522, which induced high levels of interferon (IFN)-gamma-producing CD4+ T cells in three of four HLA-DR3-positive CMV-seropositive individuals up to 0.84% of CD4+ T cells by intracellular cytokine staining. In peripheral blood mononuclear cells from M. tuberculosis-exposed, Mycobacterium bovis bacille Calmette-Guérin (BCG)-vaccinated, or CMV-seropositive individuals, we were able to directly detect with both tetramers epitope-specific T cells up to 0.62% and 0.45% of the CD4+ T-cell population reactive to M. tuberculosis and CMV, respectively. After a 6-day culture with peptide p510-522, the frequency of CMV-specific tetramer-binding T cells was expanded up to 9.90% tetramer+ CFSElow (5,6-carboxyfluorescein diacetate succinimidyl ester) cells within the CD4+ T-cell population, further confirming the specificity of the tetrameric molecules. Thus, HLA-DR3/peptide tetrameric molecules can be used to investigate HLA-DR3-restricted antigen-specific CD4+ T cells in clinical disease or after vaccination.

  10. VizieR Online Data Catalog: New z>=3.6 QSOs from FIRST-SDSS DR5 (Carballo+, 2008)

    NASA Astrophysics Data System (ADS)

    Carballo, R.; Gonzalez-Serrano, J. I.; Benn, C. R.; Jimenez-Lujan, F.

    2009-03-01

    We aim to obtain a complete sample of redshift z>=3.6 radio quasi-stellar objects (QSOs) from the Faint Images of the Radio Sky at Twenty cm survey (FIRST) sources (S1.4GHz>1mJy) having star-like counterparts in the Sloan Digital Sky Survey (SDSS) Data Release 5 (DR5) photometric survey (rAB<=20.2). Our starting sample of 8665 FIRST-DR5 pairs includes 4250 objects with spectra in DR5, 52 of these being z>=3.6 QSOs. We found that simple supervised neural networks, trained on the sources with DR5 spectra, and using optical photometry and radio data, are very effective for identifying high-z QSOs in a sample without spectra. For the sources with DR5 spectra the technique yields a completeness (fraction of actual high-z QSOs classified as such by the neural network) of 96 per cent, and an efficiency (fraction of objects selected by the neural network as high-z QSOs that actually are high-z QSOs) of 62 per cent. Applying the trained networks to the 4415 sources without DR5 spectra we found 58 z>=3.6 QSO candidates. We obtained spectra of 27 of them, and 17 are confirmed as high-z QSOs. Spectra of 13 additional candidates from the literature and from SDSS Data Release 6 (DR6) revealed seven more z>=3.6 QSOs, giving an overall efficiency of 60 per cent (24/40). (2 data files).

  11. Role of FAT/CD36 in fatty acid sensing, energy, and glucose homeostasis regulation in DIO and DR rats

    PubMed Central

    Dunn-Meynell, Ambrose A.; Levin, Barry E.

    2014-01-01

    Hypothalamic fatty acid (FA) sensing neurons alter their activity utilizing the FA translocator/receptor, FAT/CD36. Depletion of ventromedial hypothalamus (VMH) CD36 with adeno-associated viral vector expressing CD36 shRNA (AAV CD36 shRNA) leads to redistribution of adipose stores and insulin resistance in outbred rats. This study assessed the requirement of VMH CD36-mediated FA sensing for the regulation of energy and glucose homeostasis in postnatal day 5 (P5) and P21 selectively bred diet-induced obese (DIO) and diet-resistant (DR) rats using VMH AAV CD36 shRNA injections. P5 CD36 depletion altered VMH neuronal FA sensing predominantly in DIO rats. After 10 wk on a 45% fat diet, DIO rats injected with VMH AAV CD36 shRNA at P21 ate more and gained more weight than DIO AAV controls, while DR AAV CD36 shRNA-injected rats gained less weight than DR AAV controls. VMH CD36 depletion increased inguinal fat pad weights and leptin levels in DIO and DR rats. Although DR AAV CD36 shRNA-injected rats became as obese as DIO AAV controls, only DIO control and CD36 depleted rats became insulin-resistant on a 45% fat diet. VMH CD36 depletion stunted linear growth in DIO and DR rats. DIO rats injected with AAV CD36 shRNA at P5 had increased fat mass, mostly due to a 45% increase in subcutaneous fat. They were also insulin-resistant with an associated 71% increase of liver triglycerides. These results demonstrate that VMH CD36-mediated FA sensing is a critical factor in the regulation of energy and glucose homeostasis and fat deposition in DIO and DR rats. PMID:25477422

  12. Notes on the history of the Dr. Senckenbergische Anatomie in Frankfurt/Main. Part II. The Dr. Senckenbergische Anatomie during the Third Reich and its body supply.

    PubMed

    Brehm, Thomas Theo; Korf, Horst-Werner; Benzenhöfer, Udo; Schomerus, Christof; Wicht, Helmut

    2015-09-01

    In order to be able to understand how body supply was maintained at the Dr. Senckenbergische Anatomie from 1933 to 1945 - with special emphasis on victims of the National Socialist regime - we have collected information from various and often fragmentary sources. The documents reveal that during this period at least 474 bodies were brought to the anatomical institute. Among them were the bodies of at least 71 prisoners, 51 of whom had been executed, and the bodies of 8 inmates of (labor-) camps. 356 unclaimed bodies were received, some of them may stem from victims of "euthanasia" programs. The sources of 39, as of yet, unnamed bodies could not be verified. The current collections and the catalogs were screened for remains of victims of the National Socialist regime, but none were found. The vast majority of the bodies were used for teaching purposes. Hans Schreiber, one of the directors of the institute, whose biography is provided here, used at least 9 additional executed individuals for his research. Wherever possible, we have identified the victims of the National Socialist regime, executed persons and the inmates of (labor-) camps, whose bodies were used by the anatomists in Frankfurt, by name. Among the victims was Georg Fröba, a communist philanthropist, whose biography is provided. PMID:26198687

  13. Rheumatic fever in Ireland: the role of Dr Monica Lea Wilson (1889-1971).

    PubMed

    Ward, O Conor

    2013-02-01

    In 1869 William Stokes pointed out that the severity of rheumatic fever in Dublin had declined over recent decades. Similar worldwide decline led to the closure of many internationally famous rheumatic fever centres. The discovery by Robert Collis that rheumatic fever was a sequel to haemolytic streptococcal infection and the subsequent discovery of penicillin accelerated the decline. St Gabriel's Hospital in Dublin opened in 1951 under the clinical direction of Dr Monica Lea Wilson. Contrary to contemporary medical opinion a regimen of very prolonged bed rest was enforced. From 1961 the family doctors became concerned at the adverse psychological effects of the unnecessarily prolonged hospital stay. Twenty-seven of the 56 inpatients were re-assessed. None of them showed any evidence of active rheumatic fever and their parents took them home. The hospital closed in 1968. Dr Lea Wilson distanced herself from mainstream medicine and she is best remembered for having presented an unrecognized Caravaggio painting to the Jesuit Order in recognition of their pastoral support at the time of the controversial assassination in 1920 of her husband Percival, an Inspector in the Royal Irish Constabulary.

  14. Comparative soil metal analyses in Sudbury (Ontario, Canada) and Lubumbashi (Katanga, DR-Congo).

    PubMed

    Narendrula, R; Nkongolo, K K; Beckett, P

    2012-02-01

    DR-Congo is a main world producer of copper (Cu) and cobalt (Co). Several hydrometallurgical plants and smelters also produced zinc, arsenic, and cadmium as by-products. In Sudbury (Canada), the production of nickel, copper and other metals has been maintained at high levels while industrial SO(2) emissions have been reduced by approximately 90% through combination of industrial technological developments and legislated controls. Metal analysis in the present study revealed that the levels of copper and cobalt in soils from mining sites in the Lubumbashi (DR-Congo) were up to 200 fold higher compared to contaminated Sudbury sites and tailings. Zinc content in soil samples from some mining areas in Lubumbashi was at least 70 times higher compared to samples from the Sudbury area. Nickel content in soil samples from Lubumbashi were much lower compared to the Sudbury Region samples. Overall, this study confirms that the African Copper belt region is among the ten most polluted areas in the world. PMID:22139330

  15. The leadership principles of Dr. Martin Luther King, Jr. and their relevance to surgery.

    PubMed Central

    Brunicardi, F. Charles; Cotton, Ronald T.; Cole, George W.; Martinez, George

    2007-01-01

    In order to face the challenges in healthcare this century, it is essential that surgeons understand modern leadership principles. One of the greatest leaders in history was Dr. Martin Luther King, Jr., who provides a shining example of level-5 leadership for us to study. The study of leadership principles of great leaders can provide us with practical methods of conflict resolution as well as inspiration to keep us engaged and focused. As leaders of the medical community, we face numerous challenges, including discovering and implementing new treatments for disease, providing care for the indigent, overcoming educational challenges such as incorporating the ACGME Core Competencies into our surgical training and promoting diversity in education. Achieving these goals is often hindered by the environment in which we labor-nearly 50 million are uninsured, the rising cost of medical care is currently at 16% of the GNP, and reimbursement rates are falling-which makes the practice of surgery a significant challenge. Effective leadership will be paramount in achieving these goals. In this editorial, which summarizes a presentation given to the Surgical Section of the annual National Medical Association meeting, five important leadership principles that are important for surgeons have been selected and related to the outstanding leadership of Dr. Martin Luther King, Jr. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 PMID:17304963

  16. Rheumatic fever in Ireland: the role of Dr Monica Lea Wilson (1889-1971).

    PubMed

    Ward, O Conor

    2013-02-01

    In 1869 William Stokes pointed out that the severity of rheumatic fever in Dublin had declined over recent decades. Similar worldwide decline led to the closure of many internationally famous rheumatic fever centres. The discovery by Robert Collis that rheumatic fever was a sequel to haemolytic streptococcal infection and the subsequent discovery of penicillin accelerated the decline. St Gabriel's Hospital in Dublin opened in 1951 under the clinical direction of Dr Monica Lea Wilson. Contrary to contemporary medical opinion a regimen of very prolonged bed rest was enforced. From 1961 the family doctors became concerned at the adverse psychological effects of the unnecessarily prolonged hospital stay. Twenty-seven of the 56 inpatients were re-assessed. None of them showed any evidence of active rheumatic fever and their parents took them home. The hospital closed in 1968. Dr Lea Wilson distanced herself from mainstream medicine and she is best remembered for having presented an unrecognized Caravaggio painting to the Jesuit Order in recognition of their pastoral support at the time of the controversial assassination in 1920 of her husband Percival, an Inspector in the Royal Irish Constabulary. PMID:23610223

  17. High times, fair maidens, and sweet air: romantic interludes in the life of Dr. Crawford Long.

    PubMed

    Lyke, Austin

    2014-10-01

    How does one's knowledge of pain affect the physical "being" of pain? Following German idealist philosophy, unconsciousness to such knowledge would seemingly abdicate the very nature of pain. "Nothing exists but thoughts!--the universe is composed of impressions, ideas, pleasures, and pains!" Humphry Davy exclaimed upon leaping out of the laughing gas chamber where he had breathed some 100 quarts of nitrous oxide. The discovery of nitrous oxide gas as an agent of transubstantiation led to the discovery of the medical science of anesthesia by a genius, but backcountry physician, Dr. Crawford Long in 1841. This paper presupposes that the Romantically introspective effects of diethyl ether inhalation led Dr. Long to yearn melancholically for his lover and underestimate his momentous discovery, as the physical abdication of pain could not quench the doctor's subliminal anguish. Within is an account of the arcane nature of one of medicine and history's most significant discoveries, one wrought out of intelligence and the wondrous curiosity of the Romantic period.

  18. THE YOUNG STELLAR POPULATION OF THE CYGNUS-X DR15 REGION

    SciTech Connect

    Rivera-Gálvez, S.; Román-Zúñiga, C. G.; Jiménez-Bailón, E.; Ybarra, J. E.; Alves, J. F.

    2015-12-15

    We present a multi-wavelength study of the young stellar population in the Cygnus-X DR15 region. We studied young stars that were forming or recently formed at and around the tip of a prominent molecular pillar and an infrared dark cloud. Using a combination of ground-based near-infrared, space-based infrared, and X-ray data, we constructed a point source catalog from which we identified 226 young stellar sources, which we classified into evolutionary classes. We studied their spatial distributions across the molecular gas structures and identified several groups that possibly belong to distinct young star clusters. We obtained samples of these groups and constructed K-band luminosity functions that we compared with those of artificial clusters, allowing us to make first order estimates of the mean ages and age spreads of the groups. We used a {sup 13}CO(1-0) map to investigate the gas kinematics at the prominent gaseous envelope of the central cluster in DR15, and we inferred that the removal of this envelope is relatively slow compared to other cluster regions, in which the gas dispersal timescale could be similar or shorter than the circumstellar disk dissipation timescale. The presence of other groups with slightly older ages, associated with much less prominent gaseous structures, may imply that the evolution of young clusters in this part of the complex proceeds in periods that last 3–5 Myr, perhaps after a slow dissipation of their dense molecular cloud birthplaces.

  19. The leadership principles of Dr. Martin Luther King, Jr. and their relevance to surgery.

    PubMed

    Brunicardi, F Charles; Cotton, Ronald T; Cole, George W; Martinez, George

    2007-01-01

    In order to face the challenges in healthcare this century, it is essential that surgeons understand modern leadership principles. One of the greatest leaders in history was Dr. Martin Luther King, Jr., who provides a shining example of level-5 leadership for us to study. The study of leadership principles of great leaders can provide us with practical methods of conflict resolution as well as inspiration to keep us engaged and focused. As leaders of the medical community, we face numerous challenges, including discovering and implementing new treatments for disease, providing care for the indigent, overcoming educational challenges such as incorporating the ACGME Core Competencies into our surgical training and promoting diversity in education. Achieving these goals is often hindered by the environment in which we labor-nearly 50 million are uninsured, the rising cost of medical care is currently at 16% of the GNP, and reimbursement rates are falling-which makes the practice of surgery a significant challenge. Effective leadership will be paramount in achieving these goals. In this editorial, which summarizes a presentation given to the Surgical Section of the annual National Medical Association meeting, five important leadership principles that are important for surgeons have been selected and related to the outstanding leadership of Dr. Martin Luther King, Jr.

  20. Dr. Auzoux's botanical teaching models and medical education at the universities of Glasgow and Aberdeen.

    PubMed

    Olszewski, Margaret Maria

    2011-09-01

    In the 1860s, Dr. Louis Thomas Jérôme Auzoux introduced a set of papier-mâché teaching models intended for use in the botanical classroom. These botanical models quickly made their way into the educational curricula of institutions around the world. Within these institutions, Auzoux's models were principally used to fulfil educational goals, but their incorporation into diverse curricula also suggests they were used to implement agendas beyond botanical instruction. This essay examines the various uses and meanings of Dr. Auzoux's botanical teaching models at the universities of Glasgow and Aberdeen in the nineteenth century. The two main conclusions of this analysis are: (1) investing in prestigious scientific collections was a way for these universities to attract fee-paying students so that better medical accommodation could be provided and (2) models were used to transmit different kinds of botanical knowledge at both universities. The style of botany at the University of Glasgow was offensive and the department there actively embraced and incorporated ideas of the emerging new botany. At Aberdeen, the style of botany was defensive and there was some hesitancy when confronting new botanical ideas.

  1. Research of Helium Isotopes in Taiwan: The Legacy of Dr. Tsanyao Frank Yang

    NASA Astrophysics Data System (ADS)

    Yang, Tsanyao Frank; Lan, Tefang; Lee, Hsiao-Fen; Fu, Ching-Chou; Chuang, Pei-Chuan; Hong, Wei-Li; Walia, Vivek; Chen, Hsuan-Wen; Wen, Hsin-Yi; Chen, Ai-Ti; Chen, Hsiao-Chi; Chiu, Chun-Ming; Cheng, Chun-Yuan; Wu, Nian-Ru; Cheng, Yu-Chen; Chuang, Jin-Lun; Kao, Li-Hsin; Chen, Cheng-Hong; Sano, Yuji

    2016-04-01

    Helium isotope systematics is a powerful proxy to distinguish fluid origins and conveys fruitful geological information. In the past several decades, this robust isotope systematics had offered pivotal knowledge on many key issues in Earth and planetary sciences. It revealed essential geological information of Taiwan as well. Taiwan is located on the junction of two subduction systems-Ryukyu Arc and Luzon Arc. The geotectonic setting is complex and intriguing. Dr. Tsanyao Frank Yang was the pioneer of gas geochemistry studies in Taiwan. He established the first gas geochemistry laboratory in National Taiwan University in 1998 and started exploring all possible research topics on and around this tectonic-active island. In the past two decades, his research covered volcanic/hydrothermal gas studies, volcanic activity monitoring, gas hydrate exploration, soil gas as a tool to locate fault traces, soil gas flux measurement, earthquake precursory, mud volcanoes, low-temperature geochronology and many more. He died of pancreas cancer in March 2015. He was a warm and enthusiastic mentor, a prolific scientist and a great friend. He will always be remembered. Here we present Dr. Yang's achievement on helium isotopes studies in Taiwan throughout his research career. We integrate all the research results from his team and summarize the observations. We will show the distribution of helium isotope ratios in Taiwan and its implications on tectonic settings.

  2. [DR. SHOSHANA SZKOP-FRENKIEL: THE FIRST FEMALE PLASTIC SURGEON IN ISRAEL].

    PubMed

    Shehory-Rubin, Zipora

    2015-11-01

    In the history of Israeli medicine, Dr. Shoshana Szkop-Frenkiel is regarded as the first plastic surgeon in the country and among the founders of the profession of plastic surgery. This article describes the long road she traveled, from her acceptance into medical studies in Vilna--at a time when the entry of any woman to the faculty of medicine was strictly limited and of Jewish women in particular; her emigration to Eretz Israel and her struggles as she underwent training in internal medicine at the "Hadassah" Hospital in Tel-Aviv, when she was denied training as a surgeon; and up to the moment she was accepted by the plastic surgery unit of the Tel Hashomer Hospital and became the first such female practitioner in Israel. Dr. Shoshana Szkop-Frenkiel thus fulfilled a childhood dream to become a surgeon at a time when women were excluded from surgery on the grounds that it called for "male" characteristics. This article is intended to illustrate the character of a female doctor pursuing a career in surgery during the time of the British Mandate, to illuminate her professional travails in Israel, and to emphasize her important contribution in the field.

  3. Dr. Harvey Cushing's attempts to cure migraine based on theories of pathophysiology.

    PubMed

    Latimer, Katherine; Pendleton, Courtney; Rosenberg, Jason; Cohen-Gadol, Aaron A; Quiñones-Hinojosa, Alfredo

    2011-11-01

    A multitude of theories characterized medical thought on migraine in the early 20th century. Newly discovered historical case files revealed Dr. Harvey Cushing's previously unpublished early attempts at surgical cure of migraine. Following institutional review board approval, and through the courtesy of the Alan Mason Chesney Archives, the authors reviewed the microfilm surgical records for The Johns Hopkins Hospital from 1896 to 1912. Patients undergoing surgical intervention by Dr. Harvey Cushing for the treatment of migraine were selected for further review. All 4 patients in the series were women and ranged in age from 29 to 41 years old. The women were admitted and observed in the hospital until a migraine occurred. Surgeries were performed while the women were in the midst of an attack. Cushing used surgical strategies including decompression, temporal artery ligation, and removal of the spine of the second vertebra. In each case, the patients' headaches eventually returned following surgery. Cushing relied on a combination of contemporary theories on migraine including humeral science, vasospastic theory, organic cause, and increased intracranial pressure. His unpublished efforts foreshadowed future surgical efforts at curing migraines. PMID:21682563

  4. High times, fair maidens, and sweet air: romantic interludes in the life of Dr. Crawford Long.

    PubMed

    Lyke, Austin

    2014-10-01

    How does one's knowledge of pain affect the physical "being" of pain? Following German idealist philosophy, unconsciousness to such knowledge would seemingly abdicate the very nature of pain. "Nothing exists but thoughts!--the universe is composed of impressions, ideas, pleasures, and pains!" Humphry Davy exclaimed upon leaping out of the laughing gas chamber where he had breathed some 100 quarts of nitrous oxide. The discovery of nitrous oxide gas as an agent of transubstantiation led to the discovery of the medical science of anesthesia by a genius, but backcountry physician, Dr. Crawford Long in 1841. This paper presupposes that the Romantically introspective effects of diethyl ether inhalation led Dr. Long to yearn melancholically for his lover and underestimate his momentous discovery, as the physical abdication of pain could not quench the doctor's subliminal anguish. Within is an account of the arcane nature of one of medicine and history's most significant discoveries, one wrought out of intelligence and the wondrous curiosity of the Romantic period. PMID:25345268

  5. Analysis of ROC on chest direct digital radiography (DR) after image processing in diagnosis of SARS

    NASA Astrophysics Data System (ADS)

    Lv, Guozheng; Lan, Rihui; Zeng, Qingsi; Zheng, Zhong

    2004-05-01

    The Severe Acute Respiratory Syndrome (SARS, also called Infectious Atypical Pneumonia), which initially broke out in late 2002, has threatened the public"s health seriously. How to confirm the patients contracting SARS becomes an urgent issue in diagnosis. This paper intends to evaluate the importance of Image Processing in the diagnosis on SARS at the early stage. Receiver Operating Characteristics (ROC) analysis has been employed in this study to compare the value of DR images in the diagnosis of SARS patients before and after image processing by Symphony Software supplied by E-Com Technology Ltd., and DR image study of 72 confirmed or suspected SARS patients were reviewed respectively. All the images taken from the studied patients were processed by Symphony. Both the original and processed images were taken into ROC analysis, based on which the ROC graph for each group of images has been produced as described below: For processed images: a = 1.9745, b = 1.4275, SA = 0.8714; For original images: a = 0.9066, b = 0.8310, SA = 0.7572; (a - intercept, b - slop, SA - Area below the curve). The result shows significant difference between the original images and processed images (P<0.01). In summary, the images processed by Symphony are superior to the original ones in detecting the opacity lesion, and increases the accuracy of SARS diagnosis.

  6. Functional expression of a cattle MHC class II DR-like antigen on mouse L cells

    SciTech Connect

    Fraser, D.C.; Craigmile, S.; Campbell, J.D.M.

    1996-09-01

    Cattle DRA and DRB genes, cloned by reverse-transcription polymerase chain reaction, were transfected into mouse L cells. The cattle DR-expressing L-cell transfectant generated was analyzed serologically, biochemically, and functionally. Sequence analysis of the transfected DRB gene clearly showed showed that it was DRB3 allele DRB3*0101, which corresponds to the 1D-IEF-determined allele DRBF3. 1D-IEF analysis of the tranfectant confirmed that the expressed DR product was DRBF3. Functional integrity of the transfected gene products was demonstrated by the ability of the transfectant cell line to present two antigens (the foot-and-mouth disease virus-derived peptide FMDV15, and ovalbumin) to antigen-specific CD4{sup +} T cells from both the original animal used to obtain the genes, and also from an unrelated DRBF3{sup +} heterozygous animal. Such transfectants will be invaluable tools, allowing us to dissect the precise contributions each locus product makes to the overall immune response in heterozygous animals, information essential for rational vaccine design. 45 refs., 5 figs., 1 tab.

  7. A software tool for quality assurance of computed/digital radiography (CR/DR) systems

    NASA Astrophysics Data System (ADS)

    Desai, Nikunj; Valentino, Daniel J.

    2011-03-01

    The recommended methods to test the performance of computed radiography (CR) systems have been established by The American Association of Physicists in Medicine, Report No. 93, "Acceptance Testing and Quality Control of Photostimulable Storage Phosphor Imaging Systems". The quality assurance tests are categorized by how frequently they need to be performed. Quality assurance of CR systems is the responsibility of the facility that performs the exam and is governed by the state in which the facility is located. For Example, the New York State Department of Health has established a guide which lists the tests that a CR facility must perform for quality assurance. This study aims at educating the reader about the new quality assurance requirements defined by the state. It further demonstrates an easy to use software tool, henceforth referred to as the Digital Physicist, developed to aid a radiologic facility in conforming with state guidelines and monitoring quality assurance of CR/DR imaging systems. The Digital Physicist provides a vendor independent procedure for quality assurance of CR/DR systems. Further it, generates a PDF report with a brief description of these tests and the obtained results.

  8. Differential alloreactivity at SLA-DR and -DQ matching in two-way mixed lymphocyte culture.

    PubMed

    Hosokawa-Kanai, Tomoko; Tanioka, Yoshikuni; Tanigawa, Manabu; Matsumoto, Yasunobu; Ueda, Susumu; Onodera, Takashi; Matsumoto, Yoshitsugu

    2002-02-01

    The major histocompatibility complex (MHC) class II molecules are heterodimeric cell surface glycoproteins important for antigen presentation to CD4+ T lymphocytes. Class II molecules of the pig MHC, termed SLA, identified so far include DR and DQ. Thus far, functional differences between products of different loci in SLalpha class II have not been well characterized. For detailed research on this issue, SLalpha-DRbeta1 and -DQbeta typings were newly developed by restriction fragment length polymorphism (RFLP) of the reverse transcriptase-polymerase chain reaction (RT-PCR) products. Using this method, several RFLP types were chosen from 13 CSK miniature pigs, and alloreactivities in two-way mixed lymphocyte culture (MLC) derived from these pigs were examined by cell proliferation assay using flow cytometry. The responses in MLC varied according to the degree of phenotype difference. In MLC from individuals of the same RFLP type in both SLA-DRbeta1 and -DQbeta, the proliferative responses showed slight reaction indicating that they were not so stimulated by each other. On the other hand, for the RFLP type-mismatching combination, the responses were strong indicating that they recognized each others alloantigens. The reactivity of only the DQbeta mismatching combination was as strong as those of only the DRbeta1 mismatching combination. These data indicate the important role of the DQ as well as DR molecule on alloreactivity in MLC.

  9. Proc, Dr. Sam, Uncle Henry, and the "Little Green Book". Interview by Charles F. Wooley.

    PubMed

    Harvey, W Proctor

    2005-01-01

    During his house staff training before World War II, Dr. W. Proctor Harvey encountered Dr. Samuel A. Levine at the Peter Bent Brigham Hospital in Boston. Following military service, Harvey returned to Boston and became Levine's first cardiology fellow. The book Clinical Auscultation of the Heart--the Little Green Book by Levine and Harvey in 1949 combined Levine's clinical wisdom with Harvey's objective phonocardiographic methods and brought an important objective dimension to the art of cardiac auscultation. Both Levine and Harvey shared experiences and friendship with Henry Christian, the first Physician-in-Chief when the new Brigham Hospital Opened in 1913. Christian, appointed Dean of the Harvard Medical School in 1908 at the age of 32, was referred to as the "Boy Dean." He held the Hersey Chair of Theory and Practice of Physic from 1908 until 1939, was one of the founding group of the American Society for Clinical Investigation, and a major force in academic medicine. Levine served as intern to Christian and then joined the Brigham medical staff in 1915. Proctor Harvey followed Henry Christian's path from their mutual hometown of Lyunchburg, VA to the Peter Bent Brigham Hospital. A series of illuminating and respectful professional interactions--initially between Christian and Levine, between Levine and Harvey in the early 1940s, and between Harvey and Christian in the 1950s--provide the background for the genesis of the Little Green Book and a remarkable example of academic heritage.

  10. Dr. Wernher von Braun With the Apollo 11 Saturn V Launch Vehicle

    NASA Technical Reports Server (NTRS)

    1969-01-01

    Dr. Wernher von Braun, director of the NASA Marshall Space Flight center (MSFC), talks with news reporters while paused in front of the mobile launcher and base of the Saturn V rocket (AS-506) being readied for the historic Apollo 11 lunar landing mission at the Kennedy Space Center (KSC). The Saturn V vehicle was developed by MSFC under the direction of Dr. von Braun. The Apollo 11 mission launched from the KSC in Florida via the MSFC developed Saturn V launch vehicle on July 16, 1969 and safely returned to Earth on July 24, 1969. Aboard the space craft were astronauts Neil A. Armstrong, commander; Michael Collins, Command Module (CM) pilot; and Edwin E. (Buzz) Aldrin Jr., Lunar Module (LM) pilot. The CM, 'Columbia', piloted by Collins, remained in a parking orbit around the Moon while the LM, 'Eagle'', carrying astronauts Armstrong and Aldrin, landed on the Moon. On July 20, 1969, Armstrong was the first human to ever stand on the lunar surface, followed by Aldrin. During 2½ hours of surface exploration, the crew collected 47 pounds of lunar surface material for analysis back on Earth. With the success of Apollo 11, the national objective to land men on the Moon and return them safely to Earth had been accomplished.

  11. Dr. Wernher von Braun With the Apollo 11 Saturn V Launch Vehicle

    NASA Technical Reports Server (NTRS)

    1969-01-01

    Dr. Wernher von Braun, director of the NASA Marshall Space Flight center (MSFC), appears proud as he pauses in front of the mobile launcher and base of the Saturn V rocket (AS-506) being readied for the historic Apollo 11 lunar landing mission at the Kennedy Space Center (KSC). The Saturn V vehicle was developed by MSFC under the direction of Dr. von Braun. The Apollo 11 mission launched from KSC in Florida via the MSFC developed Saturn V launch vehicle on July 16, 1969 and safely returned to Earth on July 24, 1969. Aboard the space craft were astronauts Neil A. Armstrong, commander; Michael Collins, Command Module (CM) pilot; and Edwin E. (Buzz) Aldrin Jr., Lunar Module (LM) pilot. The CM, 'Columbia', piloted by Collins, remained in a parking orbit around the Moon while the LM, 'Eagle'', carrying astronauts Armstrong and Aldrin, landed on the Moon. On July 20, 1969, Armstrong was the first human to ever stand on the lunar surface, followed by Aldrin. During 2½ hours of surface exploration, the crew collected 47 pounds of lunar surface material for analysis back on Earth. With the success of Apollo 11, the national objective to land men on the Moon and return them safely to Earth had been accomplished.

  12. Hughlings Jackson's Dr Z: the paradigm of temporal lobe epilepsy revealed

    PubMed Central

    Taylor, David C; Marsh, Susan M

    1980-01-01

    On 10 January 1894, a distinguished physician died in London of an overdose of chloral hydrate. The event was of vital interest to Hughlings Jackson who attended the post-mortem examination with a bevy of witnesses. He begged his colleague Walter Colman “to search the taste region of Ferrier on each half of the brain very carefully.” They were rewarded by finding “ a very small focus of softening in that region (in the uncinate gyrus) of the left half of the brain.” Jackson had thus discovered the most discrete and circumscribed lesion of the temporal lobe yet described to assoicate with the most detailed and elegant self report of psychomotor epilepsy yet published. For the physician, whom Jackson and Colman called “Dr Z” in their report in Brain2 had been Jackson's patient since 1877 and his own account of his epileptic experience had occupied six pages of Jackson's 1888 article “On a particular variety of epilepsy....”7 Jackson had himself witnessed several of Dr Z's attacks. The case enabled Jackson to argue that the complex symptomatology of the seizure was due to “reflex” effects of epileptic discharges in that area of brain. It is the paradigm of temporal lobe epilepsy. Images PMID:6999129

  13. A tribute to Dr. Robert C. Allen, an inspirational teacher, humanitarian, and friend (Nov. 18, 1950-Mar. 24, 2005).

    PubMed

    Edlich, Richard F; Greene, Jill A; Long, William B

    2006-01-01

    Dr. Robert C. Allen was a gifted educator, as well as experienced ophthalmologist, who was a close personal friend of Dr. Edlich at the University of Virginia Health System. While serving on the faculty at the University of Virginia Health System, Dr. Allen proved to be a compassionate physician, who developed close personal relationships with the residents, faculty, and his patients. Dr. Allen was invited by Dr Edlich to be a member of the Editorial Board of the Journal of Long-Term Effects of Medical Implants. When Dr. Allen told Dr. Edlich that he had ocular melanoma in 2000, this news was a wake-up call to Dr. Edlich on the need to prevent skin cancer, as well as ocular melanoma. Empowered by this news, Dr. Edlich was honored to co-author four articles on skin cancer prevention, as well as the latest article focusing on prevention of ocular melanoma. The Ocular Melanoma Foundation (Richmond, VA (USA)) was founded in 2003 by Dr. Robert C. Allen to increase awareness, enhance education, and provide advocacy among both patients and health care professionals regarding this rare, but potentially lethal cancer. It has a website that provides patient information, up-to-date information and enables communication/ discourse between and among patients and practitioners (admin@ocularmelanoma.org). Dr. Allen died on March 24, 2005, at his home surrounded by family and loved ones. When surgeons are faced with challenging healthcare diseases, Dr. Edlich's mentor, Dr. Owen Wangensteen, advised Dr. Edlich that he should seek the advice and guidance of skilled basic scientists, who are familiar with the problem. Dr. Wangensteen is recognized as the greatest surgical teacher during the 20th century. Consequently, Dr. Edlich enlisted the advice and guidance from the two co-authors of the next article regarding the scientific basis for the selection of sunglasses to prevent the development of cataracts, pterygia, skin cancer, as well as ocular melanoma. Dr. Reichow is a Professor

  14. Detection of HLA-DR on microglia in the human brain is a function of both clinical and technical factors.

    PubMed Central

    Mattiace, L. A.; Davies, P.; Dickson, D. W.

    1990-01-01

    Detection of HLA-DR, a class II major histocompatibility antigen, on glial cells is dependent not only on duration and type of tissue fixation and processing, but also on clinical factors. Glial cells labeled by anti-HLA-DR were consistent with microglia by light microscopic and ultrastructural criteria, and were colabeled with other microglial markers, including LN-1, Leu-M5, and leukocyte common antigen (LCA). In young and elderly subjects who died suddenly, anti-HLA-DR labeled microglia in the white matter, but far fewer cells in the gray matter. In subjects who died of chronic debilitating illness, such as Alzheimer's disease and carcinomatosis, anti-HLA-DR labeled numerous microglia throughout both the gray and white matter. In Alzheimer's disease, microglia were aggregated in compact senile plaques, but loosely associated with diffuse amyloid deposits. These results suggest that HLA-DR may be constitutively expressed in white matter, but induced in gray matter microglia in chronic disease states or in association with amyloid deposits. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 PMID:1693471

  15. Long-term silencing of autoimmune diabetes and improved life expectancy by a soluble pHLA-DR4 chimera in a newly-humanized NOD/DR4/B7 mouse.

    PubMed

    Pow Sang, Luis; Majji, Sai; Casares, Sofia; Brumeanu, Teodor D

    2014-01-01

    Several human MHC class II (HLA) molecules are strongly associated with high incidence of autoimmune diseases including type 1 diabetes (T1D). The HLA-humanized mice may thus represent valuable tools to test HLA-based vaccines and therapeutics for human autoimmune diseases. Herein, we have tested the therapeutic potential of a soluble HLA-DR4-GAD65 271-280 (hu DEF-GAD65) chimera of human use in a newly-generated NOD/DR4/B7 double transgenic (dTg) mouse that develops spontaneously an accelerated T1D regardless the gender. The NOD/DR4/B7 dTg mice generated by a two-step crossing protocol express the HLA-DR*0401 molecules on 20% of antigen presenting cells, the human B7 molecules in pancreas, and HLA-DR4/GAD65-specific T-cells in the blood. Some 75% of pre-diabetic NOD/DR4/B7 dTg mice treated with hu DEF-GAD65 chimera remained euglycemic and showed a stabilized pancreatic insulitis 6 months after treatment. The 25% non responders developing hyperglycemia survived 3-4 months longer than their untreated littermates. T1D prevention by this reagent occurred by a Th2/TR-1 polarization in the pancreas. This study strongly suggests that the use of soluble pHLA reagents to suppress/stabilize the T1D progression and to extend the life expectancy in the absence of side effects is an efficient and safe therapeutic approach.

  16. Alveolar epithelial cells in idiopathic pulmonary fibrosis display upregulation of TRAIL, DR4 and DR5 expression with simultaneous preferential over-expression of pro-apoptotic marker p53

    PubMed Central

    Akram, Khondoker M; Lomas, Nicola J; Forsyth, Nicholas R; Spiteri, Monica A

    2014-01-01

    Idiopathic pulmonary fibrosis (IPF) is a progressive, debilitating, and fatal lung disease of unknown aetiology with no current cure. The pathogenesis of IPF remains unclear but repeated alveolar epithelial cell (AEC) injuries and subsequent apoptosis are believed to be among the initiating/ongoing triggers. However, the precise mechanism of apoptotic induction is hitherto elusive. In this study, we investigated expression of a panel of pro-apoptotic and cell cycle regulatory proteins in 21 IPF and 19 control lung tissue samples. We reveal significant upregulation of the apoptosis-inducing ligand TRAIL and its cognate receptors DR4 and DR5 in AEC within active lesions of IPF lungs. This upregulation was accompanied by pro-apoptotic protein p53 overexpression. In contrast, myofibroblasts within the fibroblastic foci of IPF lungs exhibited high TRAIL, DR4 and DR5 expression but negligible p53 expression. Similarly, p53 expression was absent or negligible in IPF and control alveolar macrophages and lymphocytes. No significant differences in TRAIL expression were noted in these cell types between IPF and control lungs. However, DR4 and DR5 upregulation was detected in IPF alveolar macrophages and lymphocytes. The marker of cellular senescence p21WAF1 was upregulated within affected AEC in IPF lungs. Cell cycle regulatory proteins Cyclin D1 and SOCS3 were significantly enhanced in AEC within the remodelled fibrotic areas of IPF lungs but expression was negligible in myofibroblasts. Taken together these findings suggest that, within the remodelled fibrotic areas of IPF, AEC can display markers associated with proliferation, senescence, and apoptotosis, where TRAIL could drive the apoptotic response. Clear understanding of disease processes and identification of therapeutic targets will direct us to develop effective therapies for IPF. PMID:24551275

  17. HLA-DR4 subtype frequencies in rheumatoid arthritis indicate that DRB1 is the major susceptibility locus within the HLA class II region

    SciTech Connect

    Wordsworth, B.P.; Bell, J.I. ); Lanchbury, J.S.S.; Sakkas, L.I.; Welsh, K.I.; Panayi, G.S. )

    1989-12-01

    Susceptibility to rheumatoid arthritis (RA) may be due to the presence of shared functional epitopes common the HLA-DR {beta} chains of several RA-associated haplotypes. The authors have obtained direct evidence for this hypothesis by using the polymerase chain reaction and sequencing the DRB1 and DQB1 genes from RA patients. A highly conserved epitope present on DR {beta} chains of DR4 and DR1 haplotypes was found in 83% of 149 patients with classical or definite RA but was found in only 46% of 100 control individuals. Two Dw subtypes of DR4 (Dw4 and Dw14) were associated with disease susceptibility but two other subtypes (Dw10 and Dw13) were not. Sequence differences between these subtypes implicate those residues around the putative antigen binding site of the DR {beta} molecule in the pathogenesis of RA. These data provide a basis for understanding host susceptibility to RA at a molecular level.

  18. A novel HLA-DR13 allele (DRB1*1314) identified by single-strand conformation polymorphism analysis and confirmed by direct sequencing.

    PubMed

    Blasczyk, R; van Lessen, A; Schwella, N; Huhn, D; Salama, A

    1995-08-01

    A novel variant of the HLA-DR13 group is described. The new allele was found in a DR10, 13 heterozygous patient of Turkish origin, two HLA genotypically identical children of the patient typed as DR11,13, and one child typed as DR13,13. DR13 subtyping of the patient was initially performed by SSCP analysis of PCR-amplified DNA, using the 11th OHWS primers DRBAMP-3 and DRBAMP-B. Due to an unusual SSCP banding pattern, the PCR product was subjected to solid-phase sequencing. The sequence of the new allele, DRB1*1314, is different from that of DRB1*1307 by a single nucleotide substitution in codon 47, with T replacing consensus A. This results in a single amino acid change of tryptophan to phenylalanine in the first domain of the DR beta chain. PMID:7499179

  19. Summary of Symposium on Cloud Systems, Hurricanes and TRMM: Celebration of Dr. Joanne Simpson's Career, The First Fifty Years

    NASA Technical Reports Server (NTRS)

    Tao, W.-K.; Adler, R.; Braun, S.; Einaudi, F.; Ferrier, B.; Halverson, J.; Heymsfield, G.; Kummerow, C.; Negri, A.; Kakar, R.; Einaudi, Franco (Technical Monitor)

    2000-01-01

    A symposium celebrating the first 50 years of Dr. Joanne Simpson's career took place at the NASA/Goddard Space Flight Center from December 1 - 3, 1999. This symposium consisted of presentations that focused on: historical and personal points of view concerning Dr. Simpson's research career, her interactions with the American Meteorological Society, and her leadership in TRMM; scientific interactions with Dr. Simpson that influenced personal research; research related to observations and modeling of clouds, cloud systems and hurricanes; and research related to the Tropical Rainfall Measuring Mission (TRMM). There were a total of 36 presentations and 103 participants from the US, Japan and Australia. The specific presentations during the symposium are summarized in this paper.

  20. Enhancement by gamma-interferon of in vivo tumor radiolocalization by a monoclonal antibody against HLA-DR antigen

    SciTech Connect

    Rowlinson, G.; Balkwill, F.; Snook, D.; Hooker, G.; Epenetos, A.A.

    1986-12-01

    Athymic nu/nu (nude) mice bearing s.c. human breast tumors were treated systemically with recombinant human gamma-interferon. These tumors were phenotypically negative for HLA-DR prior to therapy, but after 4 days of treatment, 80% of the cells expressed this antigen in vivo as assessed by immunoperoxidase (F. R. Balkwill et al., Eur. J. Cancer Clin. Oncol., in press, 1986). A radioiodine-labeled murine monoclonal antibody (TAL-1B5) against HLA-DR specifically localized to the tumors in recombinant human gamma-interferon-treated but not in control mice. An isotype-identical murine monoclonal antibody that did not react with control or recombinant human gamma-interferon-treated tumors did not show any specific localization. These results demonstrate that specific localization to tumors of radio-labeled monoclonal antibodies to HLA-DR can be facilitated by systemic therapy with gamma-interferon.