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Sample records for met office unified

  1. Exoplanet modelling with the Met Office Unified Model

    NASA Astrophysics Data System (ADS)

    Boutle, Ian; Lines, Stefan; Mayne, Nathan; Lee, Graham; Helling, Christiane; Drummond, Ben; Manners, James; Goyal, Jayesh; Lambert, Hugo; Acreman, David; Earnshaw, Paul; Amundsen, David; Baraffe, Isabelle

    2017-04-01

    This talk will present an overview of work being done to adapt the Unified Model, one of the most sophisticated weather and climate models of this planet, into a flexible planet simulator for use in the study of any exoplanet. We will focus on two current projects: Clouds in hot Jupiter atmospheres - recent HST observations have revealed a continuum in atmospheric composition from cloudy to clear skies. The presence of clouds is inferred from a grey opacity in the near-IR that mutes key absorption features in the transmission spectra. Unlike the L-T Brown Dwarf sequence, this transition does not correlate well with equilibrium temperature, suggesting that a cloud formation scheme more comprehensive than simply considering the condensation temperature needed for homogenous cloud growth, is required. In our work, we conduct 3D simulations of cloud nucleation, growth, advection, evaporation and gravitational settling in the atmospheres of HD209458b and HD189733 using the kinetic and mixed-grain cloud formation code DIHRT, coupled to the Unified Model. We explore cloud composition, vertical structure and particle sizes, as well as highlighting the importance of the strong atmospheric dynamics seen in tidally locked hot Jupiters on the evolution and distribution of the cloud. Climate of Proxima B - we present results of simulations of the climate of the newly discovered planet Proxima Centauri B, examining the responses of both an `Earth-like' atmosphere and simplified nitrogen and trace carbon dioxide atmosphere to the radiation likely received. Overall, our results are in agreement with previous studies in suggesting Proxima Centauri B may well have surface temperatures conducive to the presence of liquid water. Moreover, we have expanded the parameter regime over which the planet may support liquid water to higher values of eccentricity and lower incident fluxes, guided by observational constraints. This increased parameter space arises because of the low sensitivity

  2. The evaluation and development of the Met Office Unified Model using surface and space borne radar.

    NASA Astrophysics Data System (ADS)

    Petch, J.

    2012-12-01

    The Met Office Unified Model is used for the prediction of weather and climate on time scales of hours through to centuries. Therefore, the parametrizations in that model need to work on weather and climate timescale, and with grid-lengths from hundres of meters through to several hundred kilometres. Focusing on the development of the cloud and radiation schemes I will discuss how we are using ground-based remote-sensing observations from Chilbolton (England) and a combination of Cloudsat and Calipso data to evaluate and improve the performance of the model. I will show how the prediction of the clouds has improved since the AR5 version of the model and how we have developed an improved cloud generator to rebresent the sub-grid variability of clouds for radiative transfer.

  3. Exploring the climate of Proxima B with the Met Office Unified Model

    NASA Astrophysics Data System (ADS)

    Boutle, Ian A.; Mayne, Nathan J.; Drummond, Benjamin; Manners, James; Goyal, Jayesh; Hugo Lambert, F.; Acreman, David M.; Earnshaw, Paul D.

    2017-05-01

    We present results of simulations of the climate of the newly discovered planet Proxima Centauri B, performed using the Met Office Unified Model (UM). We examine the responses of both an "Earth-like" atmosphere and simplified nitrogen and trace carbon dioxide atmosphere to the radiation likely received by Proxima Centauri B. Additionally, we explore the effects of orbital eccentricity on the planetary conditions using a range of eccentricities guided by the observational constraints. Overall, our results are in agreement with previous studies in suggesting Proxima Centauri B may well have surface temperatures conducive to the presence of liquid water. Moreover, we have expanded the parameter regime over which the planet may support liquid water to higher values of eccentricity (≳0.1) and lower incident fluxes (881.7 W m-2) than previous work. This increased parameter space arises because of the low sensitivity of the planet to changes in stellar flux, a consequence of the stellar spectrum and orbital configuration. However, we also find interesting differences from previous simulations, such as cooler mean surface temperatures for the tidally-locked case. Finally, we have produced high-resolution planetary emission and reflectance spectra, and highlight signatures of gases vital to the evolution of complex life on Earth (oxygen, ozone and carbon dioxide).

  4. Evaluating the Met Office Unified Model simulated land surface temperature (LST) in northwest India

    NASA Astrophysics Data System (ADS)

    Brooke, Jennifer; Harlow, Chawn; Webster, Stuart; Gallego-Elvira, Belen

    2017-04-01

    Surface temperature biases in northwest India in the Met Office Unified Model (UM) show significant heterogeneity with distinct regions of warm and cold biases. This work will show verification of model biases through ground-based, in-situ airborne and satellite observations during the Interaction of Convective Organisation and Monsoon Precipitation, Atmosphere, Surface and Sea (INCOMPASS) campaign in northern India between May - July 2016. The INCOMPASS project is part of the "Drivers of Variability" which is a programme funded jointly by Natural Environment Research Council (NERC), the Newton fund, Indian Ministry of Earth Sciences (MoES) National Monsoon Mission, and the Met Office. MODIS climatological data and near-real time retrievals have been used to investigate the spatial biases in LST and how they correlate with model surface cover. The surface temperature biases (both warm and cold biases) in the INCOMPASS 4.4 km south Asia limited area domain are more dominant in June than May; the May MODIS climatology comparison showed the cold bias was most dominant between 72 and 75 oE, and in the June climatology comparison the cold bias had extended to almost 80 oE. The spatial distribution and magnitude of surface temperature biases and how they correlate with surface vegetation cover in the northwest region was investigated for a number of sub-regions. Region 1 (25 to 26 oN) was found to have the largest mean cold surface temperature bias and a strong correlation coefficients between the surface temperature biases and the IGBP vegetation fractional cover dataset with R2 of 0.81 (bare soil) and 0.72 (grasses). This is further supported by the strong positive correlation coefficients between the bare soil cover fraction and the cold surface temperature bias between the INCOMPASS 4.4km model and MODIS climatology for both May and June. It will be shown that regions with warm surface temperature bias in northwest India are not strongly correlated to surface cover

  5. INFERNO, a simple approach for interactive fires and their emissions within the Met Office Unified Model

    NASA Astrophysics Data System (ADS)

    Mangeon, Stephane; Voulgarakis, Apostolos; Folberth, Gerd

    2015-04-01

    Forest fires remain a crucial element of the Earth system, affecting and affected by the biosphere and the atmosphere. In particular emissions of trace gases (CO2, CO, NOx...) from forest fires can affect radiative forcing as well as atmospheric composition, similarly aerosols such as Black Carbon (also a strong sunlight absorber) and Organic Carbon emitted by fires can participate in cloud droplet nucleation, contributing to the aerosol indirect effect. Global estimates of fire emissions have greatly improved over the last decade, mainly through the developments in satellite observations. However, such estimates remain constrained to the recent satellite observational period; to study fires under past and future climates one has to resort to models. We will present the INteractive Fire and Emission algoRithm for Natural envirOnments (INFERNO) scheme for the Met Office's Unified Model, which builds on previous work for the GISS climate model. We start from simulated fire counts using proxies for flammability (meteorology and vegetation), ignitions and fire suppression. We then extend this parameterisation to predict burnt area, burnt biomass and subsequent emissions. This climate-sensitive parameterisation utilises temperature, relative humidity, precipitation and vegetation modelling (biomass and leaf area index) to model flammability. Ignitions depend on population density and lightning strikes. Of all these variables, only population density needs to be prescribed, hence INFERNO can be run interactively within a coupled earth system model. Our approach is also distinct owing to its simplicity and is computationally inexpensive, a necessary characteristic as it is aimed to run interactively over climatological timescales. The performance of this scheme is assessed against the Global Fire Emissions Database (GFED); early analysis shows this new approach effectively captures the spatial and inter-annual variability of burnt area and fire emissions of CO2 and CO

  6. Extreme precipitation over European river basins in global Met Office Unified Model high-resolution climate simulations

    NASA Astrophysics Data System (ADS)

    Schiemann, Reinhard; Demory, Marie-Estelle; Mizielinski, Matthew S.; Roberts, Malcolm J.; Strachan, Jane; Vidale, Pier Luigi

    2016-04-01

    Flood events affecting large European river basins, with a drainage area on the order of 100 000 square kilometres, are largely caused by extreme precipitation over these river basins immediately preceding the river floods and lasting for one or several days. In this study, we evaluate the representation of such extreme precipitation events in the Met Office Unified Model (MetUM). Extreme-value distributions of basin-scale precipitation are estimated for high-resolution (down to about 25 km grid spacing) global MetUM simulations conducted in the project UPSCALE (UK on PRACE: weather- resolving Simulations of Climate for globAL Environmental risk), and for gridded gauge-based reference precipitation from the European Climate Assessment & Dataset (ECA&D) E-OBS product. Particular emphasis will be placed on how the representation of these extreme events depends on the horizontal grid resolution of the global atmospheric UPSCALE simulations.

  7. The Effect of an Increased Convective Entrainment Rate on Indian Monsoon Biases in the Met Office Unified Model

    NASA Astrophysics Data System (ADS)

    Bush, S. J.; Turner, A. G.; Woolnough, S.; Martin, G.

    2012-12-01

    Global circulation models (GCMs) are a key tool for understanding and predicting monsoon rainfall, now and under future climate change. However, many GCMs show significant, systematic biases in their simulation of monsoon rainfall and dynamics. We describe several of these biases as simulated in the Met Office Unified Model and show they are sensitive to changes in the convective entrainment rate (Figure 1). To improve our understanding of the biases and inform efforts to improve convective parameterizations, we explore the reasons for this sensitivity. We show the results of experiments where we increase the entrainment rate in regions of especially large bias: the western equatorial Indian Ocean, western north Pacific and India itself. We use the results to determine whether improvements in biases are due to the local increase in entrainment or are non-linear effects of the entrainment increase elsewhere in the GCM. We find that the local response to the entrainment rate increase is usually similar to the response in the same region when the entrainment rate is changed globally and that feedbacks tend to strengthen the local response. We also use experiments to analyse the spin-up of the local response in complex regions such as the western north Pacific. Our work demonstrates that local application of parameterization changes is a powerful tool for understanding their global impact.; Figure 1: The response of JJAS precipitation in the Asian monsoon region to increasing the convective entrainment rate by a factor of 1.5 in the Met Office Unified Model.

  8. The Effect of an Increased Convective Entrainment Rate on Indian Monsoon Biases in the Met Office Unified Model

    NASA Astrophysics Data System (ADS)

    Bush, Stephanie; Turner, Andrew; Woolnough, Steve; Martin, Gill

    2013-04-01

    Global circulation models (GCMs) are a key tool for understanding and predicting monsoon rainfall, now and under future climate change. However, many GCMs show significant, systematic biases in their simulation of monsoon rainfall and dynamics that spin up over very short time scales and persist in the climate mean state. We describe several of these biases as simulated in the Met Office Unified Model and show they are sensitive to changes in the convective parameterization's entrainment rate. To improve our understanding of the biases and inform efforts to improve convective parameterizations, we explore the reasons for this sensitivity. We show the results of experiments where we increase the entrainment rate in regions of especially large bias: the western equatorial Indian Ocean, western north Pacific and India itself. We use the results to determine whether improvements in biases are due to the local increase in entrainment or are the remote response of the entrainment increase elsewhere in the GCM. We find that feedbacks usually strengthen the local response, but the local response leads to a different mean state change in different regions. We also show results from experiments which demonstrate the spin-up of the local response, which we use to further understand the response in complex regions such as the Western North Pacific. Our work demonstrates that local application of parameterization changes is a powerful tool for understanding their global impact.

  9. Efficient performance of the Met Office Unified Model v8.2 on Intel Xeon partially used nodes

    NASA Astrophysics Data System (ADS)

    Bermous, I.

    2014-11-01

    The atmospheric Unified Model (UM) developed at the UK Met Office is used for weather and climate prediction by forecast teams at a number of international meteorological centres and research institutes on a wide variety of hardware and software environments. Over its 25 year history the UM sources have been optimised for a better application performance on a number of HPC systems including NEC SX vector architecture systems and recently the IBM Power6/Power7 platforms. Understanding the influence of the compiler flags, MPI libraries and run configurations is crucial to achieving the shortest elapsed times for a UM application on any particular HPC system. These aspects are very important for applications that must run within operational time frames. Driving the current study is the HPC industry trend since 1980 for processor arithmetic performance to increase at a faster rate than memory bandwidth. This gap has been growing especially fast for multicore processors in the past 10 years and it can have significant implication for the performance and performance scaling of memory bandwidth intensive applications, such as the UM. Analysis of partially used nodes on Intel Xeon clusters is provided in this paper for short and medium range weather forecasting systems using global and limited-area configurations. It is shown that on the Intel Xeon based clusters the fastest elapsed times and the most efficient system usage can be achieved using partially committed nodes.

  10. Efficient performance of the Met Office Unified Model v8.2 on Intel Xeon partially used nodes

    NASA Astrophysics Data System (ADS)

    Bermous, I.; Steinle, P.

    2015-03-01

    The atmospheric Unified Model (UM) developed at the UK Met Office is used for weather and climate prediction by forecast teams at a number of international meteorological centres and research institutes on a wide variety of hardware and software environments. Over its 25 year history the UM sources have been optimised for better application performance on a number of High Performance Computing (HPC) systems including NEC SX vector architecture systems and recently the IBM Power6/Power7 platforms. Understanding the influence of the compiler flags, Message Passing Interface (MPI) libraries and run configurations is crucial to achieving the shortest elapsed times for a UM application on any particular HPC system. These aspects are very important for applications that must run within operational time frames. Driving the current study is the HPC industry trend since 1980 for processor arithmetic performance to increase at a faster rate than memory bandwidth. This gap has been growing especially fast for multicore processors in the past 10 years and it can have significant implication for the performance and performance scaling of memory bandwidth intensive applications, such as the UM. Analysis of partially used nodes on Intel Xeon clusters is provided in this paper for short- and medium-range weather forecasting systems using global and limited-area configurations. It is shown that on the Intel Xeon-based clusters the fastest elapsed times and the most efficient system usage can be achieved using partially committed nodes.

  11. The impact of fires in the UK Met Office's Unified Model and the INFERNO interactive fire scheme

    NASA Astrophysics Data System (ADS)

    Mangeon, S.

    2015-12-01

    Forest fires are a key interaction between the land and the atmosphere. Yet this interaction is often omitted from Earth System Models. We will present the efforts carried out within the UK Met Office: for both its Unified Model (UM8.4) and land surface model (JULES). These efforts have focused on diagnosing fire occurrence and impact on composition. We will present the schemes used for diagnostic fire weather indices, and INFERNO (INteractive Fires and Emissions algoRithm for Natural envirOnments). INFERNO follows a reduced complexity approach and is intended for decadal to centennial scale climate simulations and assessment models for policy making. The scheme uses temperature, relative humidity, precipitation and soil moisture to simulate fuel flammability; once combined with ignitions, INFERNO diagnoses burnt area. Using JULES' carbon scheme, burnt area leads to fire emissions which are inputs to the model's chemistry and aerosol scheme (UKCA). We will show the coupled model performance in capturing burnt area and fire emissions and investigate the role of fires on atmospheric composition interannual variability (in particular CO, and aerosols).

  12. Air quality modelling using the Met Office Unified Model (AQUM OS24-26): model description and initial evaluation

    NASA Astrophysics Data System (ADS)

    Savage, N. H.; Agnew, P.; Davis, L. S.; Ordóñez, C.; Thorpe, R.; Johnson, C. E.; O'Connor, F. M.; Dalvi, M.

    2013-03-01

    The on-line air quality model AQUM (Air Quality in the Unified Model) is a limited-area forecast configuration of the Met Office Unified Model which uses the UKCA (UK Chemistry and Aerosols) sub-model. AQUM has been developed with two aims: as an operational system to deliver regional air quality forecasts and as a modelling system to conduct air quality studies to inform policy decisions on emissions controls. This paper presents a description of the model and the methods used to evaluate the performance of the forecast system against the automated UK surface network of air quality monitors. Results are presented of evaluation studies conducted for a year-long period of operational forecast trials and several past cases of poor air quality episodes. The results demonstrate that AQUM tends to over-predict ozone (~8 μg m-3 mean bias for the year-long forecast), but has a good level of responsiveness to elevated ozone episode conditions - a characteristic which is essential for forecasting poor air quality episodes. AQUM is shown to have a negative bias for PM10, while for PM2.5 the negative bias is much smaller in magnitude. An analysis of speciated PM2.5 data during an episode of elevated particulate matter (PM) suggests that the PM bias occurs mainly in the coarse component. The sensitivity of model predictions to lateral boundary conditions (LBCs) has been assessed by using LBCs from two different global reanalyses and by comparing the standard, single-nested configuration with a configuration having an intermediate European nest. We conclude that, even with a much larger regional domain, the LBCs remain an important source of model error for relatively long-lived pollutants such as ozone. To place the model performance in context we compare AQUM ozone forecasts with those of another forecasting system, the MACC (Monitoring Atmospheric Composition and Climate) ensemble, for a 5-month period. An analysis of the variation of model skill with forecast lead time is

  13. Evaluating the Met Office Unified Model simulated land surface temperature (LST) using a multi-platform approach

    NASA Astrophysics Data System (ADS)

    Brooke, Jennifer; Harlow, Chawn; Best, Martin; Newman, Stuart; Scott, Russell; Edwards, John; Thelen, Jean-Claude; Pavelin, Ed; Weeks, Mark

    2015-04-01

    The Met Office Unified Model (UM) has a significant cold bias in land surface temperature (LST) in semi-arid regions at global resolution, and limited area 4.4 km and 2.2 km configurations. The daytime LST cold bias simulated by the JULES land surface scheme within the UM is present throughout the annual cycle in semi-arid regions of the globe in comparison to IASI retrievals. These errors are largest in late spring and early summer and have magnitudes of 5 to 15 K, dependent on model resolution. This work will show verification of model biases through ground-based, in-situ airborne and satellite observations during the Semi-Arid Land Surface Temperature and IASI Calibration Experiment (SALSTICE) in semi-arid south-eastern Arizona in May 2013. Airborne observations of LST from the FAAM research aircraft using the Airborne Research Interferometer Evaluation System (ARIES) were used to investigate the spatial distribution of the model errors and evaluate IASI retrievals. Airborne retrievals of surface temperature were found to broadly agree with IASI retrievals; uncertainties are attributed to the spatial variability in the ARIES measurements compared with the IASI footprints and due to differences within the retrieval, such as assumed emissivity. The UM errors in LST were found to vary with model resolution as well as topographic complexity, with the coarse resolution global model having larger errors than the limited area models. Regions with complex terrain had the highest LST errors while the errors over the less complex basins were lower, in the range of 4-5 K. Evaluation of the JULES land surface scheme has been performed for flux tower sites in the Walnut Gulch Experimental Watershed in south-eastern Arizona. An annual dataset of flux tower measurements confirms the LST biases seen with aircraft and satellite observations and indicates that night-time LST biases are of the order of those observed during the day. Comparisons of different model resolutions show

  14. The Met Office Unified Model Global Atmosphere 6.0/6.1 and JULES Global Land 6.0/6.1 configurations

    NASA Astrophysics Data System (ADS)

    Walters, David; Boutle, Ian; Brooks, Malcolm; Melvin, Thomas; Stratton, Rachel; Vosper, Simon; Wells, Helen; Williams, Keith; Wood, Nigel; Allen, Thomas; Bushell, Andrew; Copsey, Dan; Earnshaw, Paul; Edwards, John; Gross, Markus; Hardiman, Steven; Harris, Chris; Heming, Julian; Klingaman, Nicholas; Levine, Richard; Manners, James; Martin, Gill; Milton, Sean; Mittermaier, Marion; Morcrette, Cyril; Riddick, Thomas; Roberts, Malcolm; Sanchez, Claudio; Selwood, Paul; Stirling, Alison; Smith, Chris; Suri, Dan; Tennant, Warren; Vidale, Pier Luigi; Wilkinson, Jonathan; Willett, Martin; Woolnough, Steve; Xavier, Prince

    2017-04-01

    We describe Global Atmosphere 6.0 and Global Land 6.0 (GA6.0/GL6.0): the latest science configurations of the Met Office Unified Model and JULES (Joint UK Land Environment Simulator) land surface model developed for use across all timescales. Global Atmosphere 6.0 includes the ENDGame (Even Newer Dynamics for General atmospheric modelling of the environment) dynamical core, which significantly increases mid-latitude variability improving a known model bias. Alongside developments of the model's physical parametrisations, ENDGame also increases variability in the tropics, which leads to an improved representation of tropical cyclones and other tropical phenomena. Further developments of the atmospheric and land surface parametrisations improve other aspects of model performance, including the forecasting of surface weather phenomena. We also describe GA6.1/GL6.1, which includes a small number of long-standing differences from our main trunk configurations that we continue to require for operational global weather prediction. Since July 2014, GA6.1/GL6.1 has been used by the Met Office for operational global numerical weather prediction, whilst GA6.0/GL6.0 was implemented in its remaining global prediction systems over the following year.

  15. Modelling Volcanic Aerosol-Cloud Interactions in Warm Cumulus Cloud Using the High Resolution Nested Suite of the UK Met Office Unified Model

    NASA Astrophysics Data System (ADS)

    Hodgson, A. K.; Field, P.; Carslaw, K. S.; Hill, A. A.; Shipway, B. J.; Grosvenor, D. P.; Marsham, J. H.

    2014-12-01

    The impacts that aerosols have on clouds and clouds have on aerosols remain the largest uncertainty in terms of the effect on radiative forcing. Regional and global models are unable to resolve these small scale interactions, while high resolution eddy-resolving models are unable to capture the larger scale dynamics of the atmosphere and can only be run over a limited size domain for a limited time. Here we present results using the high resolution (1km, 0.3km) nested version of the UK Met Office Unified Model (UM) which bridges the scale gap between models. A new microphysics scheme, Cloud and AeroSol Interactive Microphysics (CASIM) is coupled to a chemistry and aerosol scheme (GLOMAP-mode) which allows for fully interactive aerosol and cloud microphysics.Results showing the effect of volcanic aerosol from the slowly degassing Kilauea volcano, Hawaii on trade wind cumuli will be presented. The presence of a subtropical high pressure in the summer allows the study of aerosol-cloud interactions in a uniform unpolluted marine background environment without the complications of anthropogenic pollution. Satellite data has shown that cumulus clouds affected by the volcanic plume had smaller cloud droplets, reduced precipitation efficiency, increased cloud amount and higher cloud tops. Other researchers have hypothesised that that the observed changes in cloud properties cannot be explained by the orographic effect of the island or the sea surface temperature anomaly. We present results using CASIM in the UM at high resolution to systematically compare the relative effects of dynamical and aerosol-cloud interactions. Initial results show that the orography of the island does not have a significant impact on the cumulus cloud further downwind from the island but there is an effect in the immediate vicinity of the island. Initial results also indicate that 1km resolution is not high enough to resolve small cumulus cloud.

  16. MONIM: the new Met Office Night Illumination Model

    NASA Astrophysics Data System (ADS)

    Revell, S. J.; Hignett, P.

    2004-09-01

    This paper describes a new model developed by the Met Office to predict night-time light levels. The Met Office Night Illumination Model (MONIM) predicts light levels both in the visible (photopic) range and in the waveband to which night vision goggles (NVGs) are sensitive. The model will be used operationally for support of night-time flying operations. The model is described in detail and its light-level forecasts are compared with observations.

  17. Aerosol impacts in the Met Office global NWP model

    NASA Astrophysics Data System (ADS)

    Mulcahy, Jane P.; Brooks, Malcolm E.; Milton, Sean F.

    2010-05-01

    An accurate representation of the direct and indirect effect of aerosols is of growing concern for global numerical weather prediction (NWP). Increased scattering and absorption of incoming shortwave (SW) and outgoing longwave radiation (OLR) fields due to the presence of aerosol layers in the atmosphere modifies the atmospheric heating profile and can affect large-scale circulation patterns. The current representation of aerosols in the global NWP configuration of the Met Office Unified ModelTM (MetUM) is based on a simple aerosol climatology (Cusack et al., 1998). Profiles of water soluble dust, soot, oceanic and stratospheric sulphate aerosols are described separately for land and ocean surfaces and are distributed over the boundary layer, free troposphere and stratosphere (sulphates only). While this improved the reflected SW radiative bias at the top-of-atmosphere (TOA), there is evidence that the climatology is too absorbing leading to a temperature bias in the lower troposphere of approximately 0.5 K/day. Furthermore, the omission of the scattering and absorption properties of mineral dust and biomass burning aerosol particles in particular, is believed to be the principal cause of significant model biases (in the region of 50-56 W m-2) in both the model OLR at the TOA (Haywood et al., 2005) and the surface SW radiation fields (Milton et al., 2008). One of the objectives of the Global Aerosols (G-AER) component of the MACC (Monitoring Atmospheric Composition and Climate) project is to evaluate the impact of an improved aerosol representation on the performance of global NWP models. In a stepwise approach of increasing the aerosol complexity in the MetUM, the Cusack climatology is being replaced by the CLASSIC (Coupled Large-scale Aerosol Simulator for Studies in Climate) aerosol scheme, developed for the HadGEM (Hadley Centre Global Environmental Model) climate model. CLASSIC includes representations of external mixtures of sulphate, black carbon, organic

  18. Remote Sensing of Volcanic ASH at the Met Office

    NASA Astrophysics Data System (ADS)

    Marenco, F.; Kent, J.; Adam, M.; Buxmann, J.; Francis, P.; Haywood, J.

    2016-06-01

    The eruption of Eyjafjallajökull in 2010 has triggered the rapid development of volcanic ash remote sensing activities at the Met Office. Volcanic ash qualitative and quantitative mapping have been achieved using lidar on board the Facility for Airborne Atmospheric Measurements (FAAM) research aircraft, and using improved satellite retrieval algorithms. After the eruption, a new aircraft facility, the Met Office Civil Contingencies Aircraft (MOCCA), has been set up to enable a rapid response, and a network of ground-based remote sensing sites with lidars and sunphotometers is currently being developed. Thanks to these efforts, the United Kingdom (UK) will be much better equipped to deal with such a crisis, should it happen in the future.

  19. Operational Use of OGC Web Services at the Met Office

    NASA Astrophysics Data System (ADS)

    Wright, Bruce

    2010-05-01

    The Met Office has adopted the Service-Orientated Architecture paradigm to deliver services to a range of customers through Rich Internet Applications (RIAs). The approach uses standard Open Geospatial Consortium (OGC) web services to provide information to web-based applications through a range of generic data services. "Invent", the Met Office beta site, is used to showcase Met Office future plans for presenting web-based weather forecasts, product and information to the public. This currently hosts a freely accessible Weather Map Viewer, written in JavaScript, which accesses a Web Map Service (WMS), to deliver innovative web-based visualizations of weather and its potential impacts to the public. The intention is to engage the public in the development of new web-based services that more accurately meet their needs. As the service is intended for public use within the UK, it has been designed to support a user base of 5 million, the analysed level of UK web traffic reaching the Met Office's public weather information site. The required scalability has been realised through the use of multi-tier tile caching: - WMS requests are made for 256x256 tiles for fixed areas and zoom levels; - a Tile Cache, developed in house, efficiently serves tiles on demand, managing WMS request for the new tiles; - Edge Servers, externally hosted by Akamai, provide a highly scalable (UK-centric) service for pre-cached tiles, passing new requests to the Tile Cache; - the Invent Weather Map Viewer uses the Google Maps API to request tiles from Edge Servers. (We would expect to make use of the Web Map Tiling Service, when it becomes an OGC standard.) The Met Office delivers specialist commercial products to market sectors such as transport, utilities and defence, which exploit a Web Feature Service (WFS) for data relating forecasts and observations to specific geographic features, and a Web Coverage Service (WCS) for sub-selections of gridded data. These are locally rendered as maps or

  20. The Met Office Hadley Centre climate modelling capability: the competing requirements for improved resolution, complexity and dealing with uncertainty.

    PubMed

    Pope, V; Brown, S; Clark, R; Collins, M; Collins, W; Dearden, C; Gunson, J; Harris, G; Jones, C; Keen, A; Lowe, J; Ringer, M; Senior, C; Sitch, S; Webb, M; Woodward, S

    2007-11-15

    Predictions of future climate change require complex computer models of the climate system to represent the full range of processes and interactions that influence climate. The Met Office Hadley Centre uses 'families' of models as part of the Met Office Unified Model Framework to address different classes of problems. The HadGEM family is a suite of state-of-the-art global environment models that are used to reduce uncertainty and represent and predict complex feedbacks. The HadCM3 family is a suite of well established but cheaper models that are used for multiple simulations, for example, to quantify uncertainty or to test the impact of multiple emissions scenarios.

  1. Sandscape - engaging people in Met Office science through sand sculpture

    NASA Astrophysics Data System (ADS)

    Liggins, Felicity; Dowell, Ellen; Wardley, Jamie; Jamieson, Claire

    2017-04-01

    In 2015, the Met Office's award-winning outreach programme, designed to inspire the next generation of scientists and engineers, delivered one of its most ambitious and creative activities to date. It explored how scientists and artists can come together to create an engaging experience for young people and families. This activity was called Sandscape. Sandscape is an interactive sand sculpture workshop exploring how weather and climate affect our health. Budding sand sculptors are shown how to fashion elaborate structures from sand and water - creating a landscape with bridges, skyscrapers, forests and factories. As they work, participants are encouraged by the scientists delivering the activity to reflect on what makes a healthy city, considering how the natural and built environments influence air quality and circulation and how this impacts our health. Topics discussed include urban heat islands, air pollution and dispersion modelling, pollen forecasting and predicting the wind-borne spread of animal diseases. Each hour long workshop culminates in a dramatic demonstration that uses dry ice to represent clean air circulating from mountains, along rivers and into cities. Here we present an overview of Sandscape, identify the strengths and challenges of such a collaborative, innovative and playful approach to public engagement and share the results of our evaluation. Sandscape was originally supported by the Met Office and the Wellcome Trust, and produced by Einstein's Garden in collaboration with the Met Office, scientists from the University of Exeter and sand sculptors from Sand in Your Eye. It was first presented in Einstein's Garden at Green Man festival 2015, an independent music and arts festival held annually in Wales, and has since been invited to run at the 2015 Bournemouth Arts By the Sea Festival and Teignmouth's TRAIL Sculpture Festival in the summer of 2016.

  2. Seasonal to decadal climate services at the Met Office

    NASA Astrophysics Data System (ADS)

    Brookshaw, A.; Arribas, A.; Graham, R.; Vellinga, M.; Fereday, D.

    2012-12-01

    For several years the Met Office, the UK's National Met service, has been providing climate services to a large range of users - from government organisations, both national and international, to commercial customers. This presentation will describe our current activities and future plans for development of user-relevant climate science and new products and services for monthly to decadal timescales, which build on our current role as a Global Producing Centre of long-range forecasts and key contributor to a number of operational multi-model ensembles and Regional Climate Outlook Forums. Already, much of the recent research has been geared towards applications: from making the monthly, seasonal and decadal predictability at regional scales the focus of development for the coupled climate model and the operational forecasting systems, to investigating methodologies for predicting seasonal and decadal tropical storm activity and climate and weather extremes. An example of such a development towards user-relevant applications and services will be presented in detail: the Climate Science Research Partnership (CSRP). This is a partnership between the Met Office Hadley Centre and the UK Department for International Development, aimed at advancing the quality, relevance and uptake of climate services in Africa. It has been running for almost three years, and during this period activities have ranged from fundamental climate research - focused on improving the understanding, modelling and prediction of African climate - to development of user-relevant products and activities to strengthen uptake of such science and services. The presentation will highlight key scientific results, new experimental products driven by user needs identified by consultation, as well as some of the limitations and challenges encountered along the way.

  3. Flare forecasting at the Met Office Space Weather Operations Centre

    NASA Astrophysics Data System (ADS)

    Murray, S. A.; Bingham, S.; Sharpe, M.; Jackson, D. R.

    2017-04-01

    The Met Office Space Weather Operations Centre produces 24/7/365 space weather guidance, alerts, and forecasts to a wide range of government and commercial end-users across the United Kingdom. Solar flare forecasts are one of its products, which are issued multiple times a day in two forms: forecasts for each active region on the solar disk over the next 24 h and full-disk forecasts for the next 4 days. Here the forecasting process is described in detail, as well as first verification of archived forecasts using methods commonly used in operational weather prediction. Real-time verification available for operational flare forecasting use is also described. The influence of human forecasters is highlighted, with human-edited forecasts outperforming original model results and forecasting skill decreasing over longer forecast lead times.

  4. The Met Office Global Coupled model 2.0 (GC2) configuration

    NASA Astrophysics Data System (ADS)

    Williams, K. D.; Harris, C. M.; Bodas-Salcedo, A.; Camp, J.; Comer, R. E.; Copsey, D.; Fereday, D.; Graham, T.; Hill, R.; Hinton, T.; Hyder, P.; Ineson, S.; Masato, G.; Milton, S. F.; Roberts, M. J.; Rowell, D. P.; Sanchez, C.; Shelly, A.; Sinha, B.; Walters, D. N.; West, A.; Woollings, T.; Xavier, P. K.

    2015-05-01

    The latest coupled configuration of the Met Office Unified Model (Global Coupled configuration 2, GC2) is presented. This paper documents the model components which make up the configuration (although the scientific description of these components is detailed elsewhere) and provides a description of the coupling between the components. The performance of GC2 in terms of its systematic errors is assessed using a variety of diagnostic techniques. The configuration is intended to be used by the Met Office and collaborating institutes across a range of timescales, with the seasonal forecast system (GloSea5) and climate projection system (HadGEM) being the initial users. In this paper GC2 is compared against the model currently used operationally in those two systems. Overall GC2 is shown to be an improvement on the configurations used currently, particularly in terms of modes of variability (e.g. mid-latitude and tropical cyclone intensities, the Madden-Julian Oscillation and El Nino Southern Oscillation). A number of outstanding errors are identified with the most significant being a considerable warm bias over the Southern Ocean and a dry precipitation bias in the Indian and West African summer monsoons. Research to address these is ongoing.

  5. The Met Office Global Coupled model 2.0 (GC2) configuration

    NASA Astrophysics Data System (ADS)

    Williams, K. D.; Harris, C. M.; Bodas-Salcedo, A.; Camp, J.; Comer, R. E.; Copsey, D.; Fereday, D.; Graham, T.; Hill, R.; Hinton, T.; Hyder, P.; Ineson, S.; Masato, G.; Milton, S. F.; Roberts, M. J.; Rowell, D. P.; Sanchez, C.; Shelly, A.; Sinha, B.; Walters, D. N.; West, A.; Woollings, T.; Xavier, P. K.

    2015-01-01

    The latest coupled configuration of the Met Office Unified Model (Global Coupled configuration 2, GC2) is presented. This paper documents the model components which make up the configuration (although the scientific description of these components is detailed elsewhere) and provides a description of the coupling between the components. The performance of GC2 in terms of its systematic errors is assessed using a variety of diagnostic techniques. The configuration is intended to be used by the Met Office and collaborating institutes across a range of timescales, with the seasonal forecast system (GloSea5) and climate projection system (HadGEM) being the initial users. In this paper GC2 is compared against the model currently used operationally in those two systems.

  6. Impacts of increasing the aerosol complexity in the Met Office global numerical weather prediction model

    NASA Astrophysics Data System (ADS)

    Mulcahy, J. P.; Walters, D. N.; Bellouin, N.; Milton, S. F.

    2014-05-01

    The inclusion of the direct and indirect radiative effects of aerosols in high-resolution global numerical weather prediction (NWP) models is being increasingly recognised as important for the improved accuracy of short-range weather forecasts. In this study the impacts of increasing the aerosol complexity in the global NWP configuration of the Met Office Unified Model (MetUM) are investigated. A hierarchy of aerosol representations are evaluated including three-dimensional monthly mean speciated aerosol climatologies, fully prognostic aerosols modelled using the CLASSIC aerosol scheme and finally, initialised aerosols using assimilated aerosol fields from the GEMS project. The prognostic aerosol schemes are better able to predict the temporal and spatial variation of atmospheric aerosol optical depth, which is particularly important in cases of large sporadic aerosol events such as large dust storms or forest fires. Including the direct effect of aerosols improves model biases in outgoing long-wave radiation over West Africa due to a better representation of dust. However, uncertainties in dust optical properties propagate to its direct effect and the subsequent model response. Inclusion of the indirect aerosol effects improves surface radiation biases at the North Slope of Alaska ARM site due to lower cloud amounts in high-latitude clean-air regions. This leads to improved temperature and height forecasts in this region. Impacts on the global mean model precipitation and large-scale circulation fields were found to be generally small in the short-range forecasts. However, the indirect aerosol effect leads to a strengthening of the low-level monsoon flow over the Arabian Sea and Bay of Bengal and an increase in precipitation over Southeast Asia. Regional impacts on the African Easterly Jet (AEJ) are also presented with the large dust loading in the aerosol climatology enhancing of the heat low over West Africa and weakening the AEJ. This study highlights the

  7. Impacts of increasing the aerosol complexity in the Met Office global NWP model

    NASA Astrophysics Data System (ADS)

    Mulcahy, J. P.; Walters, D. N.; Bellouin, N.; Milton, S. F.

    2013-11-01

    Inclusion of the direct and indirect radiative effects of aerosols in high resolution global numerical weather prediction (NWP) models is being increasingly recognised as important for the improved accuracy of short-range weather forecasts. In this study the impacts of increasing the aerosol complexity in the global NWP configuration of the Met Office Unified Model (MetUM) are investigated. A hierarchy of aerosol representations are evaluated including three dimensional monthly mean speciated aerosol climatologies, fully prognostic aerosols modelled using the CLASSIC aerosol scheme and finally, initialised aerosols using assimilated aerosol fields from the GEMS project. The prognostic aerosol schemes are better able to predict the temporal and spatial variation of atmospheric aerosol optical depth, which is particularly important in cases of large sporadic aerosol events such as large dust storms or forest fires. Including the direct effect of aerosols improves model biases in outgoing longwave radiation over West Africa due to a better representation of dust. However, uncertainties in dust optical properties propogate to its direct effect and the subsequent model response. Inclusion of the indirect aerosol effects improves surface radiation biases at the North Slope of Alaska ARM site due to lower cloud amounts in high latitude clean air regions. This leads to improved temperature and height forecasts in this region. Impacts on the global mean model precipitation and large-scale circulation fields were found to be generally small in the short range forecasts. However, the indirect aerosol effect leads to a strengthening of the low level monsoon flow over the Arabian Sea and Bay of Bengal and an increase in precipitation over Southeast Asia. Regional impacts on the African Easterly Jet (AEJ) are also presented with the large dust loading in the aerosol climatology enhancing of the heat low over West Africa and weakening the AEJ. This study highlights the importance

  8. Impacts of increasing the aerosol complexity in the Met Office global NWP model

    NASA Astrophysics Data System (ADS)

    Mulcahy, Jane; Walters, David; Bellouin, Nicolas; Milton, Sean

    2014-05-01

    Inclusion of the direct and indirect radiative effects of aerosols in high resolution global numerical weather prediction (NWP) models is being increasingly recognised as important for the improved accuracy of short-range weather forecasts. In this study the impacts of increasing the aerosol complexity in the global NWP configuration of the Met Office Unified Model (MetUM) are investigated. A hierarchy of aerosol representations are evaluated including three dimensional monthly mean speciated aerosol climatologies, fully prognostic aerosols modelled using the CLASSIC aerosol scheme and finally, initialised aerosols using assimilated aerosol fields from the GEMS project. The prognostic aerosol schemes are better able to predict the temporal and spatial variation of atmospheric aerosol optical depth, which is particularly important in cases of large sporadic aerosol events such as large dust storms or forest fires. Including the direct effect of aerosols improves model biases in outgoing longwave radiation over West Africa due to a better representation of dust. Inclusion of the indirect aerosol effects has significant impacts on the SW radiation particularly at high latitudes due to lower cloud amounts in high latitude clean air regions. This leads to improved surface radiation biases at the North Slope of Alaska ARM site. Verification of temperature and height forecasts is also improved in this region. Impacts on the global mean model precipitation and large-scale circulation fields were found to be generally small in the short range forecasts. However, the indirect aerosol effect leads to a strengthening of the low level monsoon flow over the Arabian Sea and Bay of Bengal and an increase in precipitation over Southeast Asia. This study highlights the importance of including a more realistic treatment of aerosol-cloud interactions in global NWP models and the potential for improved global environmental prediction systems through the incorporation of more complex

  9. Dynamic and Thermodynamic Evolution of Indian Monsoon Onset in the Initialized Coupled Seasonal Forecasting Model of the UK Met Office

    NASA Astrophysics Data System (ADS)

    Menon, A.; Turner, A. G.; Martin, G.

    2016-12-01

    The Indian summer monsoon onset and evolution has major socioeconomic impacts on the population of the country as more than 60% of agriculture in India is rainfed. Understanding and predicting the Indian monsoon onset and progression remains a challenge to the modelling community. In this study we use hindcast simulations from the Met Office fully coupled atmosphere-ocean Global Seasonal Forecast System 5 (GloSea5) to examine the monsoon onset and progression over India. The GloSea5 simulations are produced for three different start dates, one in late April and two in early May, and both the atmosphere and ocean are initialized. We use common objective indices based on circulation and wind shear to determine the onset date over India and find that the dynamic indices obtained from GloSea5 hindcasts are consistent with that from the ERA-Interim reanalysis dataset. GloSea5 is also very effective in capturing the spatial pattern of the monsoon rainfall progression following the onset. We next analyse the composite evolution of various dynamic and thermodynamic fields associated with these indices, focusing on recent findings suggesting the importance of dry air incursions above the surface from the northwest. We further extend our analysis by using the Met Office Unified Model nesting suite with updated forcing datasets to examine the sensitivity of the model to a range of horizontal resolutions in simulating the onset and progression of 2016 Indian monsoon.

  10. The Met Office Coupled Atmosphere/Land/Ocean/Sea-Ice Data Assimilation System

    NASA Astrophysics Data System (ADS)

    Lea, Daniel; Mirouze, Isabelle; King, Robert; Martin, Matthew; Hines, Adrian

    2015-04-01

    The Met Office has developed a weakly-coupled data assimilation (DA) system using the global coupled model HadGEM3 (Hadley Centre Global Environment Model, version 3). At present the analysis from separate ocean and atmosphere DA systems are combined to produced coupled forecasts. The aim of coupled DA is to produce a more consistent analysis for coupled forecasts which may lead to less initialisation shock and improved forecast performance. The HadGEM3 coupled model combines the atmospheric model UM (Unified Model) at 60 km horizontal resolution on 85 vertical levels, the ocean model NEMO (Nucleus for European Modelling of the Ocean) at 25 km (at the equator) horizontal resolution on 75 vertical levels, and the sea-ice model CICE at the same resolution as NEMO. The atmosphere and the ocean/sea-ice fields are coupled every 1-hour using the OASIS coupler. The coupled model is corrected using two separate 6-hour window data assimilation systems: a 4D-Var for the atmosphere with associated soil moisture content nudging and snow analysis schemes on the one hand, and a 3D-Var FGAT for the ocean and sea-ice on the other hand. The background information in the DA systems comes from a previous 6-hour forecast of the coupled model. To isolate the impact of the coupled DA, 13-month experiments have been carried out, including 1) a full atmosphere/land/ocean/sea-ice coupled DA run, 2) an atmosphere-only run forced by OSTIA SSTs and sea-ice with atmosphere and land DA, and 3) an ocean-only run forced by atmospheric fields from run 2 with ocean and sea-ice DA. In addition, 5-day and 10-day forecast runs, have been produced from initial conditions generated by either run 1 or a combination of runs 2 and 3. The different results have been compared to each other and, whenever possible, to other references such as the Met Office atmosphere and ocean operational analyses or the OSTIA SST data. The performance of the coupled DA is similar to the existing separate ocean and atmosphere

  11. In Brief: U.K. Met Office forecast for Atlantic hurricane season

    NASA Astrophysics Data System (ADS)

    2007-07-01

    GloSea, the U.K. Meteorological Office's computer model of the global atmosphere-ocean system, has predicted a cooling trend in sea surface temperatures in the tropical North Atlantic that will result in a less active hurricane season. The Met Office has predicted that there is a 70% chance of a less active hurricane season in the North Atlantic this year, with only 7-13 named storms occurring within the remaining five months of the season (July through November). There have already been two named storms this year-Andrea and Barry. From 1990-2005, there were an average of 12.4 storms during July-November. The U.K. Met Office forecast contrasts with NOAA's, which was released in May and predicted a busier season than average, with 13-17 named storms.

  12. Teaching weather and climate science in primary schools - a pilot project from the UK Met Office

    NASA Astrophysics Data System (ADS)

    Orrell, Richard; Liggins, Felicity; Challenger, Lesley; Lethem, Dom; Campbell, Katy

    2017-04-01

    Wow Schools is a pilot project from the Met Office with an aim to inspire and educate the next generation of scientists and, uniquely, use the data collected by schools to improve weather forecasts and warnings across the UK. Wow Schools was launched in late 2015 with a competition open to primary schools across the UK. 74 schools entered the draw, all hoping to be picked as one of the ten lucky schools taking part in the pilot scheme. Each winning school received a fully automatic weather station (AWS), enabling them to transmit real-time local weather observations to the Met Office's Weather Observation Website (WOW - wow.metoffice.gov.uk), an award winning web portal for uploading and sharing a range of environmental observations. They were also given a package of materials designed to get students out of the classroom to observe the weather, get hands-on with the science underpinning weather forecasting, and analyse the data they are collecting. The curriculum-relevant materials were designed with the age group 7 to 11 in mind, but could be extended to support other age groups. Each school was offered a visit by a Wow Schools Ambassador (a Met Office employee) to bring the students' learning to life, and access to a dedicated forecast for its location generated by our new supercomputer. These forecasts are improved by the school's onsite AWS reinforcing the link between observations and forecast production. The Wow Schools pilot ran throughout 2016. Here, we present the initial findings of the project, examining the potential benefits and challenges of working with schools across the UK to: enrich students' understanding of the science of weather forecasting; to source an ongoing supply of weather observations and discover how these might be used in the forecasting process; and explore what materials and business model(s) would be most useful and affordable if a wider roll-out of the initiative was undertaken.

  13. Signal to Noise Ratio Estimations for a Volcanic ASH Detection Lidar. Case Study: The Met Office

    NASA Astrophysics Data System (ADS)

    Georgoussis, George; Adam, Mariana; Avdikos, George

    2016-06-01

    In this paper we calculate the Signal-to-Noise (SNR) ratio of a 3-channel commercial (Raymetics) volcanic ash detection system, (LR111-D300), already operating under Met Office organization. The methodology for the accurate estimation is presented for day and nighttime conditions. The results show that SNR values are higher than 10 for ranges up to 13 km for both nighttime and daytime conditions. This is a quite good result compared with other values presented in bibliography and proves that such system is able to detect volcanic ash over a range of 20 km.

  14. Research priorities in support of ocean monitoring and forecasting at the Met Office

    NASA Astrophysics Data System (ADS)

    Siddorn, J. R.; Good, S. A.; Harris, C. M.; Lewis, H. W.; Maksymczuk, J.; Martin, M. J.; Saulter, A.

    2016-02-01

    Ocean monitoring and forecasting services are increasingly being used by a diverse community of public and commercial organizations. The Met Office, as the body responsible for severe weather prediction, has for many years been involved in providing forecasts of aspects of the marine environment. This paper describes how these have evolved to include a range of wave, surge, and ocean reanalysis, analysis, and forecasts services. To support these services, and to ensure they evolve to meet the demands of users and are based on the best available science, a number of scientific challenges need to be addressed. The paper goes on to summarize the key challenges, and highlights some priorities for the ocean monitoring and forecasting research group at the Met Office. There is a need to both develop the underpinning science of the modelling and data assimilation systems and to maximize the benefits from observations and other inputs to the systems. Systematic evaluation underpins this science, and also needs to be the focus of research.

  15. Research priorities in support of ocean monitoring and forecasting at the Met Office

    NASA Astrophysics Data System (ADS)

    Siddorn, J. R.; Good, S. A.; Harris, C. M.; Lewis, H. W.; Maksymczuk, J.; Martin, M. J.; Saulter, A.

    2015-11-01

    Ocean monitoring and forecasting services are increasingly being used by a diverse community of public and commercial organisations. The Met Office, as the body responsible for severe weather prediction, has for many years been involved in providing forecasts of aspects of the marine environment. This paper describes how these have evolved to include a range of wave, surge and ocean reanalysis, analysis and forecasts services. To support these services, and to ensure they evolve to meet the demands of users and are based on the best available science, a number of scientific challenges need to be addressed. The paper goes on to summarise the key challenges, and highlights some priorities for the ocean monitoring and forecasting research group at the Met Office. There is a need to both develop the underpinning science of the modelling and data assimilation systems and to maximise the benefits from observations and other inputs to the systems. Systematic evaluation underpins this science, and also needs to be the focus of research.

  16. INFERNO: a fire and emissions scheme for the UK Met Office's Unified Model

    NASA Astrophysics Data System (ADS)

    Mangeon, Stéphane; Voulgarakis, Apostolos; Gilham, Richard; Harper, Anna; Sitch, Stephen; Folberth, Gerd

    2016-08-01

    Warm and dry climatological conditions favour the occurrence of forest fires. These fires then become a significant emission source to the atmosphere. Despite this global importance, fires are a local phenomenon and are difficult to represent in large-scale Earth system models (ESMs). To address this, the INteractive Fire and Emission algoRithm for Natural envirOnments (INFERNO) was developed. INFERNO follows a reduced complexity approach and is intended for decadal- to centennial-scale climate simulations and assessment models for policy making. Fuel flammability is simulated using temperature, relative humidity (RH) and fuel load as well as precipitation and soil moisture. Combining flammability with ignitions and vegetation, the burnt area is diagnosed. Emissions of carbon and key species are estimated using the carbon scheme in the Joint UK Land Environment Simulator (JULES) land surface model. JULES also possesses fire index diagnostics, which we document and compare with our fire scheme. We found INFERNO captured global burnt area variability better than individual indices, and these performed best for their native regions. Two meteorology data sets and three ignition modes are used to validate the model. INFERNO is shown to effectively diagnose global fire occurrence (R = 0.66) and emissions (R = 0.59) through an approach appropriate to the complexity of an ESM, although regional biases remain.

  17. The UK Met Office global circulation model with a sophisticated radiation scheme applied to the hot Jupiter HD 209458b

    NASA Astrophysics Data System (ADS)

    Amundsen, David S.; Mayne, Nathan J.; Baraffe, Isabelle; Manners, James; Tremblin, Pascal; Drummond, Benjamin; Smith, Chris; Acreman, David M.; Homeier, Derek

    2016-10-01

    To study the complexity of hot Jupiter atmospheres revealed by observations of increasing quality, we have adapted the UK Met Office Global Circulation Model (GCM), the Unified Model (UM), to these exoplanets. The UM solves the full 3D Navier-Stokes equations with a height-varying gravity, avoiding the simplifications used in most GCMs currently applied to exoplanets. In this work we present the coupling of the UM dynamical core to an accurate radiation scheme based on the two-stream approximation and correlated-k method with state-of-the-art opacities from ExoMol. Our first application of this model is devoted to the extensively studied hot Jupiter HD 209458b. We have derived synthetic emission spectra and phase curves, and compare them to both previous models also based on state-of-the-art radiative transfer, and to observations. We find a reasonable agreement between observations and both our days side emission and hot spot offset, however, our night side emissions is too large. Overall our results are qualitatively similar to those found by Showman et al. (2009, ApJ, 699, 564) with the SPARC/MITgcm, however, we note several quantitative differences: Our simulations show significant variation in the position of the hottest part of the atmosphere with pressure, as expected from simple timescale arguments, and in contrast to the "vertical coherency" found by Showman et al. (2009). We also see significant quantitative differences in calculated synthetic observations. Our comparisons strengthen the need for detailed intercomparisons of dynamical cores, radiation schemes and post-processing tools to understand these differences. This effort is necessary in order to make robust conclusions about these atmospheres based on GCM results.

  18. The Met Office's new operational analysis system for diurnally varying skin-SST

    NASA Astrophysics Data System (ADS)

    While, James; Mao, Chongyuan; Martin, Matthew; Good, Simon; Sykes, Peter

    2016-04-01

    Diurnal variations in skin Sea Surface Temperature (skin SST), which can be as large as several degrees, play an important role in determining the heat flux between the ocean and atmosphere. As such, since February 2015 the Met Office, as part of the Copernicus Marine Environment Monitoring Service (CMEMS), has been producing an operational analysis of the diurnal cycle of skin SST. This product consists of three components: an underlying 'foundation' SST (based on the OSTIA analysis), a warm layer where solar heating is important, and a cool skin where cooling due to long wave radiation dominates. A major development in this system is the use of a 4D-Var data assimilation technique with multiple outer-loops to improve estimates of the warm layer. Observations assimilated come from the SEVIRI, GOES-W, MTSAT2, and NOAA-AVHRR infra-red satellite instruments. Through their assimilation, the observations act to update the applied heat and wind flux such that the diurnal cycle in the warm layer is improved. In this presentation we describe the analysis system and how it produces a skin SST product. Particular attention is paid to the data assimilation aspects and on the observation processing. We also present results from a three month validation period showing that the system is well able to reproduce a drifter based climatology of the diurnal cycle in SST. A direct validation of our diurnal SST output against near surface Argo data is also given.

  19. A New Nwp Model For The Met Office - I Global Model

    NASA Astrophysics Data System (ADS)

    Cameron, D. R.; Milton, S. F.; Greed, G. T.; Culverwell, I. D.

    In spring 2002 the Met Office are planning to update the formulation of the Uni- fied Model (Cullen, 1993) used for global and mesoscale NWP. The formulation changes include both a new dynamical core for the model and a new package of parametrizations. The current dynamics is a split-explicit scheme consisting of a forward-backward scheme for the adjustment steps and a Heun scheme for advec- tion. This is being replaced by a non-hydrostatic model with a semi-implicit, semi- Lagrangian formulation. There are also major changes to the radiation scheme (Ed- wards and Slingo, 1996) and the boundary layer scheme, which allows non-local mixing in unstable regimes (Lock et al 1999). The formulation also includes a new cloud microphysics scheme with prognostic ice (Wilson and Ballard, 1999) and a new GLOBE orography dataset. The convection and gravity wave drag schemes have also been completely reformulated with the former including a new parametrization for shallow convection and the latter including a flow blocking scheme. A comprehensive set of trials of these changes have been carried out and the per- formance of the new global model will be compared to that of the current opera- tional global NWP model. In particular the new model shows improved prediction of both extratropical and tropical cyclones, and a reduction in some long standing sys- tematic errors along with a significant reduction in numerical noise. As well as the main NWP model other configurations of the model exist; these include a climate ver- sion which is still under development (HADGEM), a portable version, an idealised physics/dynamical core version and a single column version.

  20. Asian summer monsoon seasonal prediction skill in the Met Office GloSea5 model and its dependence on mean state biases

    NASA Astrophysics Data System (ADS)

    Bush, Stephanie; Turner, Andrew; Martin, Gill; Woolnough, Steve

    2015-04-01

    Predicting the circulation and precipitation features of the Asian monsoon on time scales of weeks to the season ahead remains a challenge for prediction centres. Current state-of-the-art models retain large biases, particularly dryness over India, which evolve rapidly from initialization and persist into centennial length climate integrations, illustrating the seamless nature of the monsoon problem. We present initial results from our Ministry of Earth Sciences Indian Monsoon Mission collaboration project to assess and improve weekly-to-seasonal forecasts in the Met Office Unified Model (MetUM) coupled initialized Global Seasonal Prediction System (GloSea5). Using a 14-year hindcast ensemble of integrations in which atmosphere, ocean and sea-ice components are initialized from May start dates, we assess the monsoon seasonal prediction skill and global mean state biases of GloSea5. Initial May and June biases include a lack of precipitation over the Indian peninsula, and a weakened monsoon flow, and these give way to a more robust pattern of excess precipitation in the western north Pacific, lack of precipitation over the Maritime Continent, excess westerlies across the Indian peninsula and Indochina, and cool SSTs in the eastern equatorial Indian Ocean and western north Pacific in July and August. Despite these mean state biases, the interannual correlation of predicted JJA all India rainfall from 1998 to 2009 with TRMM is fairly high at 0.68. Future work will focus on the prospects for further improving this skill with bias correction techniques.

  1. From big data analysis in the cloud to robotic pot drumming: tales from the Met Office Informatics Lab

    NASA Astrophysics Data System (ADS)

    Robinson, Niall; Tomlinson, Jacob; Prudden, Rachel; Hilson, Alex; Arribas, Alberto

    2017-04-01

    The Met Office Informatics Lab is a small multidisciplinary team which sits between science, technology and design. Our mission is simply "to make Met Office data useful" - a deliberately broad objective. Our prototypes often trial cutting edge technologies, and so far have included projects such as virtual reality data visualisation in the web browser, bots and natural language interfaces, and artificially intelligent weather warnings. In this talk we focus on our latest project, Jade, a big data analysis platform in the cloud. It is a powerful, flexible and simple to use implementation which makes extensive use of technologies such as Jupyter, Dask, containerisation, Infrastructure as Code, and auto-scaling. Crucially, Jade is flexible enough to be used for a diverse set of applications: it can present weather forecast information to meteorologists and allow climate scientists to analyse big data sets, but it is also effective for analysing non-geospatial data. As well as making data useful, the Informatics Lab also trials new working practises. In this presentation, we will talk about our experience of making a group like the Lab successful.

  2. Development of the global sea ice 6.0 CICE configuration for the Met Office global coupled model

    SciTech Connect

    Rae, J. G. L.; Hewitt, H. T.; Keen, A. B.; Ridley, J. K.; West, A. E.; Harris, C. M.; Hunke, E. C.; Walters, D. N.

    2015-07-24

    The new sea ice configuration GSI6.0, used in the Met Office global coupled configuration GC2.0, is described and the sea ice extent, thickness and volume are compared with the previous configuration and with observationally based data sets. In the Arctic, the sea ice is thicker in all seasons than in the previous configuration, and there is now better agreement of the modelled concentration and extent with the HadISST data set. As a result, in the Antarctic, a warm bias in the ocean model has been exacerbated at the higher resolution of GC2.0, leading to a large reduction in ice extent and volume; further work is required to rectify this in future configurations.

  3. Development of the global sea ice 6.0 CICE configuration for the Met Office global coupled model

    DOE PAGES

    Rae, J. G. L.; Hewitt, H. T.; Keen, A. B.; ...

    2015-07-24

    The new sea ice configuration GSI6.0, used in the Met Office global coupled configuration GC2.0, is described and the sea ice extent, thickness and volume are compared with the previous configuration and with observationally based data sets. In the Arctic, the sea ice is thicker in all seasons than in the previous configuration, and there is now better agreement of the modelled concentration and extent with the HadISST data set. As a result, in the Antarctic, a warm bias in the ocean model has been exacerbated at the higher resolution of GC2.0, leading to a large reduction in ice extentmore » and volume; further work is required to rectify this in future configurations.« less

  4. Development of global sea ice 6.0 CICE configuration for the Met Office global coupled model

    DOE PAGES

    Rae, J. . G. L; Hewitt, H. T.; Keen, A. B.; ...

    2015-03-05

    The new sea ice configuration GSI6.0, used in the Met Office global coupled configuration GC2.0, is described and the sea ice extent, thickness and volume are compared with the previous configuration and with observationally-based datasets. In the Arctic, the sea ice is thicker in all seasons than in the previous configuration, and there is now better agreement of the modelled concentration and extent with the HadISST dataset. In the Antarctic, a warm bias in the ocean model has been exacerbated at the higher resolution of GC2.0, leading to a large reduction in ice extent and volume; further work is requiredmore » to rectify this in future configurations.« less

  5. Development of global sea ice 6.0 CICE configuration for the Met Office global coupled model

    SciTech Connect

    Rae, J. . G. L; Hewitt, H. T.; Keen, A. B.; Ridley, J. K.; West, A. E.; Harris, C. M.; Hunke, E. C.; Walters, D. N.

    2015-03-05

    The new sea ice configuration GSI6.0, used in the Met Office global coupled configuration GC2.0, is described and the sea ice extent, thickness and volume are compared with the previous configuration and with observationally-based datasets. In the Arctic, the sea ice is thicker in all seasons than in the previous configuration, and there is now better agreement of the modelled concentration and extent with the HadISST dataset. In the Antarctic, a warm bias in the ocean model has been exacerbated at the higher resolution of GC2.0, leading to a large reduction in ice extent and volume; further work is required to rectify this in future configurations.

  6. Innovation in the role of the Office of the Ombudsman of the Unified Health System (SUS) - reflections and potential benefits.

    PubMed

    Fernandes, Fernando Manuel Bessa; Moreira, Marcelo Rasga; Ribeiro, José Mendes; Ouverney, Assis Mafort; Oliveira, Flávio José Fonseca de; Moro, Maria Francisca Abritta

    2016-08-01

    This article seeks to reflect on the potential of innovative practices in the design and work of the government bodies that comprise the National System of Offices of the Ombudsman of the Unified Health System. It is divided into two parts, seeking to answer the following question: How to think of and implement innovative practices - which include sustainability - when the people are voicing their urgent demands and these are being heard by the public authorities? These grievances are all the more urgent as they involve the area of Health and can they be promptly discussed, attended and resolved? In the first part, the article discusses the polysemic concept of innovation, focusing on its application in the three spheres of public administration, and highlights the importance of its close correlation with the different notions of information and knowledge in a society such as the one we live in. In the second, it develops a task-force of ideas for the office of the ombudsman and based on this, a draft operational concept of innovation in the role of the office of the ombudsman, considering the context of high speed change and transformations and the complexity inherent to contemporary life and the need for resource management and expertise development in information management.

  7. Clouds over the summertime Sahara: an evaluation of Met Office retrievals from Meteosat Second Generation using airborne remote sensing

    NASA Astrophysics Data System (ADS)

    Kealy, John C.; Marenco, Franco; Marsham, John H.; Garcia-Carreras, Luis; Francis, Pete N.; Cooke, Michael C.; Hocking, James

    2017-05-01

    Novel methods of cloud detection are applied to airborne remote sensing observations from the unique Fennec aircraft dataset, to evaluate the Met Office-derived products on cloud properties over the Sahara based on the Spinning Enhanced Visible and InfraRed Imager (SEVIRI) on-board the Meteosat Second Generation (MSG) satellite. Two cloud mask configurations are considered, as well as the retrievals of cloud-top height (CTH), and these products are compared to airborne cloud remote sensing products acquired during the Fennec campaign in June 2011 and June 2012. Most detected clouds (67 % of the total) have a horizontal extent that is smaller than a SEVIRI pixel (3 km × 3 km). We show that, when partially cloud-contaminated pixels are included, a match between the SEVIRI and aircraft datasets is found in 80 ± 8 % of the pixels. Moreover, under clear skies the datasets are shown to agree for more than 90 % of the pixels. The mean cloud field, derived from the satellite cloud mask acquired during the Fennec flights, shows that areas of high surface albedo and orography are preferred sites for Saharan cloud cover, consistent with published theories. Cloud-top height retrievals however show large discrepancies over the region, which are ascribed to limiting factors such as the cloud horizontal extent, the derived effective cloud amount, and the absorption by mineral dust. The results of the CTH analysis presented here may also have further-reaching implications for the techniques employed by other satellite applications facilities across the world.

  8. Recent development of the Met Office operational ocean forecasting system: an overview and assessment of the new Global FOAM forecasts

    NASA Astrophysics Data System (ADS)

    Blockley, E. W.; Martin, M. J.; McLaren, A. J.; Ryan, A. G.; Waters, J.; Lea, D. J.; Mirouze, I.; Peterson, K. A.; Sellar, A.; Storkey, D.

    2014-11-01

    The Forecast Ocean Assimilation Model (FOAM) is an operational ocean analysis and forecast system run daily at the Met Office. FOAM provides modelling capability in both deep ocean and coastal shelf sea regimes using the NEMO (Nucleus for European Modelling of the Ocean) ocean model as its dynamical core. The FOAM Deep Ocean suite produces analyses and 7-day forecasts of ocean tracers, currents and sea ice for the global ocean at 1/4° resolution. Satellite and in situ observations of temperature, salinity, sea level anomaly and sea ice concentration are assimilated by FOAM each day over a 48 h observation window. The FOAM Deep Ocean configurations have recently undergone a major upgrade which has involved the implementation of a new variational, first guess at appropriate time (FGAT) 3D-Var, assimilation scheme (NEMOVAR); coupling to a different, multi-thickness-category, sea ice model (CICE); the use of coordinated ocean-ice reference experiment (CORE) bulk formulae to specify the surface boundary condition; and an increased vertical resolution for the global model. In this paper the new FOAM Deep Ocean system is introduced and details of the recent changes are provided. Results are presented from 2-year reanalysis integrations of the Global FOAM configuration including an assessment of short-range ocean forecast accuracy. Comparisons are made with both the previous FOAM system and a non-assimilative FOAM system. Assessments reveal considerable improvements in the new system to the near-surface ocean and sea ice fields. However there is some degradation to sub-surface tracer fields and in equatorial regions which highlights specific areas upon which to focus future improvements.

  9. Recent development of the Met Office operational ocean forecasting system: an overview and assessment of the new Global FOAM forecasts

    NASA Astrophysics Data System (ADS)

    Blockley, E. W.; Martin, M. J.; McLaren, A. J.; Ryan, A. G.; Waters, J.; Lea, D. J.; Mirouze, I.; Peterson, K. A.; Sellar, A.; Storkey, D.

    2013-11-01

    The Forecast Ocean Assimilation Model (FOAM) is an operational ocean analysis and forecast system run daily at the Met Office. FOAM provides modelling capability in both deep ocean and coastal shelf seas regimes using the NEMO ocean model as its dynamical core. The FOAM Deep Ocean suite produces analyses and 7 day forecasts of ocean tracers, currents and sea ice for the global ocean at 1/4° resolution and at 1/12° resolution in the North Atlantic, Indian Ocean and Mediterranean Sea. Satellite and in-situ observations of temperature, salinity, sea level anomaly and sea ice concentration are assimilated by FOAM each day over a 48 h observation window. The FOAM Deep Ocean configurations have recently undergone a major upgrade which has involved: the implementation of a new variational, first guess at appropriate time 3D-Var, assimilation scheme (NEMOVAR); coupling to a different, multi-thickness-category, sea ice model (CICE); the use of CORE bulk formulae to specify the surface boundary condition; and an increased vertical resolution for the global model. In this paper the new FOAM Deep Ocean system is introduced and details of the recent changes are provided. Results are presented from 2 yr reanalysis integrations of the Global FOAM configuration including an assessment of forecast accuracy. Comparisons are made with both the previous FOAM system and a non-assimilative FOAM system. Assessments reveal considerable improvements in the new system to the near-surface ocean and sea ice fields. However there is some degradation to sub-surface tracer fields and in equatorial regions which highlight specific areas upon which to focus future improvements.

  10. The Met Office HadGEM3-ES chemistry-climate model: evaluation of stratospheric dynamics and its impact on ozone

    NASA Astrophysics Data System (ADS)

    Hardiman, Steven C.; Butchart, Neal; O'Connor, Fiona M.; Rumbold, Steven T.

    2017-03-01

    Free-running and nudged versions of a Met Office chemistry-climate model are evaluated and used to investigate the impact of dynamics versus transport and chemistry within the model on the simulated evolution of stratospheric ozone. Metrics of the dynamical processes relevant for simulating stratospheric ozone are calculated, and the free-running model is found to outperform the previous model version in 10 of the 14 metrics. In particular, large biases in stratospheric transport and tropical tropopause temperature, which existed in the previous model version, are substantially reduced, making the current model more suitable for the simulation of stratospheric ozone. The spatial structure of the ozone hole, the area of polar stratospheric clouds, and the increased ozone concentrations in the Northern Hemisphere winter stratosphere following sudden stratospheric warmings, were all found to be sensitive to the accuracy of the dynamics and were better simulated in the nudged model than in the free-running model. Whilst nudging can, in general, provide a useful tool for removing the influence of dynamical biases from the evolution of chemical fields, this study shows that issues can remain in the climatology of nudged models. Significant biases in stratospheric vertical velocities, age of air, water vapour, and total column ozone still exist in the Met Office nudged model. Further, these can lead to biases in the downward flux of ozone into the troposphere.

  11. The Role of the Plans, Operations and Medical Intelligence (POMI) Officer on the Component and Unified-level Staff

    DTIC Science & Technology

    1998-02-13

    considered to be in the realm of public health concerns. The Plans, Operations and Medical Intelligence (POMI) Officer provides the theater-level...the potential public health impact on the conduct of operations, in that commander’s area of responsibility (AOR). This information is vital to...will require an enhanced emphasis on force and population protective measures traditionally considered to be in the realm of public health concerns

  12. Boreal summer sub-seasonal variability of the South Asian monsoon in the Met Office GloSea5 initialized coupled model

    NASA Astrophysics Data System (ADS)

    Jayakumar, A.; Turner, A. G.; Johnson, S. J.; Rajagopal, E. N.; Mohandas, Saji; Mitra, A. K.

    2017-09-01

    Boreal summer sub-seasonal variability in the Asian monsoon, otherwise known as the monsoon intra-seasonal oscillation (MISO), is one of the dominant modes of intraseasonal variability in the tropics, with large impacts on total monsoon rainfall and India's agricultural production. However, our understanding of the mechanisms involved in MISO is incomplete and its simulation in various numerical models is often flawed. In this study, we focus on the objective evaluation of the fidelity of MISO simulation in the Met Office Global Seasonal forecast system version 5 (GloSea5), an initialized coupled model. We analyze a series of nine-member hindcasts from GloSea5 over 1996-2009 during the peak monsoon period (July-August) over the South-Asian monsoon domain focusing on aspects of the time-mean background state and air-sea interaction processes pertinent to MISO. Dominant modes during this period are evident in power spectrum analysis, but propagation and evolution characteristics of the MISO are not realistic. We find that simulated air-sea interactions in the central Indian Ocean are not supportive of MISO initiation in that region, likely a result of the low surface wind variance there. As a consequence, the expected near-quadrature phase relationship between SST and convection is not represented properly over the central equatorial Indian Ocean, and northward propagation from the equator is poorly simulated. This may reinforce the equatorial rainfall mean state bias in GloSea5.

  13. Evolution of Indian Ocean biases in the summer monsoon season hindcasts from the Met Office Global Seasonal Forecasting System GloSea5

    NASA Astrophysics Data System (ADS)

    Chevuturi, A.; Turner, A. G.; Woolnough, S. J.

    2016-12-01

    In this study we investigate the development of biases in the Indian Ocean region in summer hindcasts of the UK Met Office coupled initialised global seasonal forecasting system, GloSea5-GC2. Previous work has demonstrated the rapid evolution of strong monsoon circulation biases over India from seasonal forecasts initialised in early May, together with coupled strong easterly wind biases on the equator. We analyse a set of three springtime start dates for the 20-year hindcast period (1992-2011) and fifteen total ensemble members for each year. We use comparisons with a variety of observations to test the rate of evolving mean-state biases in the Arabian Sea, over India, and over the equatorial Indian Ocean. Biases are all shown to develop rapidly, particularly for the circulation bias over India that is connected to convection. These circulation biases later reach the surface and lead to responses in Arabian Sea SST in accordance with coastal and Ekman upwelling processes. We also assess the evolution of radiation and turbulent heat fluxes at the surface. Meanwhile at the equator, easterly biases in surface winds are shown to develop rapidly, consistent with an SST pattern that is consistent with positive-Indian Ocean dipole mean state conditions (warm western equatorial Indian Ocean, cold east). This bias develops consistent with coupled ocean-atmosphere exchanges and Bjerknes feedback. We hypothesize that lower tropospheric easterly wind biases developing in the equatorial region originate from the surface, and also that signals of the cold bias in the eastern equatorial Indian Ocean propagate to the Bay of Bengal via coastal Kelvin waves. Earlier work has shown the utility of wind-stress corrections in the Indian Ocean for correcting the easterly winds bias there and ultimately improving the evolution of the Indian Ocean Dipole. We identify and test this wind-stress correction technique in case study years from the hindcast period to see their impact on seasonal

  14. Evolution of dynamic and thermodynamic fields during the Indian summer monsoon onset in the initialised atmosphere-ocean seasonal forecasting model of the UK Met Office

    NASA Astrophysics Data System (ADS)

    Menon, Arathy; Turner, Andrew; Martin, Gill

    2016-04-01

    The onset of the Indian summer monsoon has significant influence on the agricultural planning that affects food production and the gross domestic product of the country. Hence understanding and prediction of the monsoon onset is of paramount importance. Here we use hindcast simulations from the Met Office fully coupled atmosphere-ocean Global Seasonal Forecast System 5 (GloSea5) to study the monsoon onset over India. The GloSea5 hindcast simulations are produced for three different start dates in late April or early May prior to the monsoon season and the atmosphere and ocean components are both initialized. Rather than focus on skill metrics of the performance at simulating the onset timing, we use common objective indices of the onset circulation and wind shears in the meridional (Wang-Fan) and vertical (Webster-Yang) directions to determine the monsoon onset over India. We find that the dynamic indices obtained from GloSea5 ensemble mean are consistent with those from the ERA-Interim reanalysis dataset. GloSea5 is also very effective in capturing the spatial pattern of the monsoon rainfall progression following the onset. We next analyse the composite evolution of various dynamic and thermodynamic fields associated with these indices, focusing on recent findings suggesting the importance of dry air incursions above the surface from the northwest. We further extend our analysis by looking at the physical mechanisms leading to onset in the GloSea5 simulations, and examine case studies comparing late and early onset years in both the model hindcasts and reanalysis data.

  15. Climate Variability over India and Bangladesh from the Perturbed UK Met Office Hadley Model: Impacts on Flow and Nutrient Fluxes in the Ganges Delta System

    NASA Astrophysics Data System (ADS)

    Whitehead, P. G.; Caesar, J.; Crossman, J.; Barbour, E.; Ledesma, J.; Futter, M. N.

    2015-12-01

    A semi-distributed flow and water quality model (INCA- Integrated Catchments Model) has been set up for the whole of the Ganges- Brahmaputra- Meghna (GBM) River system in India and Bangladesh. These massive rivers transport large fluxes of water and nutrients into the Bay of Bengal via the GBM Delta system in Bangladesh. Future climate change will impact these fluxes with changing rainfall, temperature, evapotranspiration and soil moisture deficits being altered in the catchment systems. In this study the INCA model has been used to assess potential impacts of climate change using the UK Met Office Hadley Centre GCM model linked to a regionally coupled model of South East Asia, covering India and Bangladesh. The Hadley Centre model has been pururbed by varying the parameters in the model to generate 17 realisations of future climates. Some of these reflect expected change but others capture the more extreme potential behaviour of future climate conditions. The 17 realisations have been used to drive the INCA Flow and Nitrogen model inorder to generate downstream times series of hydrology and nitrate- nitrogen. The variability of the climates on these fluxes are investigated and and their likley impact on the Bay of Begal Delta considered. Results indicate a slight shift in the monsoon season with increased wet season flows and increased temperatures which alter nutrient fluxes. Societal Importance to Stakeholders The GBM Delta supports one of the most densely populated regions of people living in poverty, who rely on ecosystem services provided by the Delta for survival. These ecosystem services are dependent upon fluxes of water and nutrients. Freshwater for urban, agriculture, and aquaculture requirements are essential to livelihoods. Nutrient loads stimulate estuarine ecosystems, supporting fishing stocks, which contribute significantly the economy of Bangladesh. Thus the societal importance of upstream climate driven change change in Bangladesh are very

  16. An assessment of Indian monsoon seasonal forecasts and mechanisms underlying monsoon interannual variability in the Met Office GloSea5-GC2 system

    NASA Astrophysics Data System (ADS)

    Johnson, Stephanie J.; Turner, Andrew; Woolnough, Steven; Martin, Gill; MacLachlan, Craig

    2017-03-01

    We assess Indian summer monsoon seasonal forecasts in GloSea5-GC2, the Met Office fully coupled subseasonal to seasonal ensemble forecasting system. Using several metrics, GloSea5-GC2 shows similar skill to other state-of-the-art seasonal forecast systems. The prediction skill of the large-scale South Asian monsoon circulation is higher than that of Indian monsoon rainfall. Using multiple linear regression analysis we evaluate relationships between Indian monsoon rainfall and five possible drivers of monsoon interannual variability. Over the time period studied (1992-2011), the El Niño-Southern Oscillation (ENSO) and the Indian Ocean dipole (IOD) are the most important of these drivers in both observations and GloSea5-GC2. Our analysis indicates that ENSO and its teleconnection with Indian rainfall are well represented in GloSea5-GC2. However, the relationship between the IOD and Indian rainfall anomalies is too weak in GloSea5-GC2, which may be limiting the prediction skill of the local monsoon circulation and Indian rainfall. We show that this weak relationship likely results from a coupled mean state bias that limits the impact of anomalous wind forcing on SST variability, resulting in erroneous IOD SST anomalies. Known difficulties in representing convective precipitation over India may also play a role. Since Indian rainfall responds weakly to the IOD, it responds more consistently to ENSO than in observations. Our assessment identifies specific coupled biases that are likely limiting GloSea5-GC2 Indian summer monsoon seasonal prediction skill, providing targets for model improvement.

  17. Evolution of Indian land surface biases in the seasonal hindcasts from the Met Office Global Seasonal Forecasting System GloSea5

    NASA Astrophysics Data System (ADS)

    Chevuturi, Amulya; Turner, Andrew G.; Woolnoug, Steve J.; Martin, Gill

    2017-04-01

    In this study we investigate the development of biases over the Indian region in summer hindcasts of the UK Met Office coupled initialised global seasonal forecasting system, GloSea5-GC2. Previous work has demonstrated the rapid evolution of strong monsoon circulation biases over India from seasonal forecasts initialised in early May, together with coupled strong easterly wind biases on the equator. These mean state biases lead to strong precipitation errors during the monsoon over the subcontinent. We analyse a set of three springtime start dates for the 20-year hindcast period (1992-2011) and fifteen total ensemble members for each year. We use comparisons with variety of observations to assess the evolution of the mean state biases over the Indian land surface. All biases within the model develop rapidly, particularly surface heat and radiation flux biases. Strong biases are present within the model climatology from pre-monsoon (May) in the surface heat fluxes over India (higher sensible / lower latent heat fluxes) when compared to observed estimates. The early evolution of such biases prior to onset rains suggests possible problems with the land surface scheme or soil moisture errors. Further analysis of soil moisture over the Indian land surface shows a dry bias present from the beginning of the hindcasts during the pre-monsoon. This lasts until the after the monsoon develops (July) after which there is a wet bias over the region. Soil moisture used for initialization of the model also shows a dry bias when compared against the observed estimates, which may lead to the same in the model. The early dry bias in the model may reduce local moisture availability through surface evaporation and thus may possibly limit precipitation recycling. On this premise, we identify and test the sensitivity of the monsoon in the model against higher soil moisture forcing. We run sensitivity experiments initiated using gridpoint-wise annual soil moisture maxima over the Indian

  18. LFRic: Building a new Unified Model

    NASA Astrophysics Data System (ADS)

    Melvin, Thomas; Mullerworth, Steve; Ford, Rupert; Maynard, Chris; Hobson, Mike

    2017-04-01

    The LFRic project, named for Lewis Fry Richardson, aims to develop a replacement for the Met Office Unified Model in order to meet the challenges which will be presented by the next generation of exascale supercomputers. This project, a collaboration between the Met Office, STFC Daresbury and the University of Manchester, builds on the earlier GungHo project to redesign the dynamical core, in partnership with NERC. The new atmospheric model aims to retain the performance of the current ENDGame dynamical core and associated subgrid physics, while also enabling a far greater scalability and flexibility to accommodate future supercomputer architectures. Design of the model revolves around a principle of a 'separation of concerns', whereby the natural science aspects of the code can be developed without worrying about the underlying architecture, while machine dependent optimisations can be carried out at a high level. These principles are put into practice through the development of an autogenerated Parallel Systems software layer (known as the PSy layer) using a domain-specific compiler called PSyclone. The prototype model includes a re-write of the dynamical core using a mixed finite element method, in which different function spaces are used to represent the various fields. It is able to run in parallel with MPI and OpenMP and has been tested on over 200,000 cores. In this talk an overview of the both the natural science and computational science implementations of the model will be presented.

  19. The impact of resolving the Rossby radius at mid-latitudes in the ocean: results from a high-resolution version of the Met Office GC2 coupled model

    NASA Astrophysics Data System (ADS)

    Hewitt, Helene T.; Roberts, Malcolm J.; Hyder, Pat; Graham, Tim; Rae, Jamie; Belcher, Stephen E.; Bourdallé-Badie, Romain; Copsey, Dan; Coward, Andrew; Guiavarch, Catherine; Harris, Chris; Hill, Richard; Hirschi, Joël J.-M.; Madec, Gurvan; Mizielinski, Matthew S.; Neininger, Erica; New, Adrian L.; Rioual, Jean-Christophe; Sinha, Bablu; Storkey, David; Shelly, Ann; Thorpe, Livia; Wood, Richard A.

    2016-10-01

    There is mounting evidence that resolving mesoscale eddies and western boundary currents as well as topographically controlled flows can play an important role in air-sea interaction associated with vertical and lateral transports of heat and salt. Here we describe the development of the Met Office Global Coupled Model version 2 (GC2) with increased resolution relative to the standard model: the ocean resolution is increased from 1/4 to 1/12° (28 to 9 km at the Equator), the atmosphere resolution increased from 60 km (N216) to 25 km (N512) and the coupling period reduced from 3 hourly to hourly. The technical developments that were required to build a version of the model at higher resolution are described as well as results from a 20-year simulation. The results demonstrate the key role played by the enhanced resolution of the ocean model: reduced sea surface temperature (SST) biases, improved ocean heat transports, deeper and stronger overturning circulation and a stronger Antarctic Circumpolar Current. Our results suggest that the improvements seen here require high resolution in both atmosphere and ocean components as well as high-frequency coupling. These results add to the body of evidence suggesting that ocean resolution is an important consideration when developing coupled models for weather and climate applications.

  20. Meteorological effects of the solar eclipse of 20 March 2015: analysis of UK Met Office automatic weather station data and comparison with automatic weather station data from the Faroes and Iceland

    PubMed Central

    Penman, John; Jónsson, Trausti; Bigg, Grant R.; Björnsson, Halldór; Sjúrðarson, Sølvi; Hansen, Mads A.; Cappelen, John; Bryant, Robert G.

    2016-01-01

    Here, we analyse high-frequency (1 min) surface air temperature, mean sea-level pressure (MSLP), wind speed and direction and cloud-cover data acquired during the solar eclipse of 20 March 2015 from 76 UK Met Office weather stations, and compare the results with those from 30 weather stations in the Faroe Islands and 148 stations in Iceland. There was a statistically significant mean UK temperature drop of 0.83±0.63°C, which occurred over 39 min on average, and the minimum temperature lagged the peak of the eclipse by about 10 min. For a subset of 14 (16) relatively clear (cloudy) stations, the mean temperature drop was 0.91±0.78 (0.31±0.40)°C but the mean temperature drops for relatively calm and windy stations were almost identical. Mean wind speed dropped significantly by 9% on average during the first half of the eclipse. There was no discernible effect of the eclipse on the wind-direction or MSLP time series, and therefore we can discount any localized eclipse cyclone effect over Britain during this event. Similar changes in air temperature and wind speed are observed for Iceland, where conditions were generally clearer, but here too there was no evidence of an eclipse cyclone; in the Faroes, there was a much more muted meteorological signature. This article is part of the themed issue ‘Atmospheric effects of solar eclipses stimulated by the 2015 UK eclipse’. PMID:27550769

  1. Meteorological effects of the solar eclipse of 20 March 2015: analysis of UK Met Office automatic weather station data and comparison with automatic weather station data from the Faroes and Iceland.

    PubMed

    Hanna, Edward; Penman, John; Jónsson, Trausti; Bigg, Grant R; Björnsson, Halldór; Sjúrðarson, Sølvi; Hansen, Mads A; Cappelen, John; Bryant, Robert G

    2016-09-28

    Here, we analyse high-frequency (1 min) surface air temperature, mean sea-level pressure (MSLP), wind speed and direction and cloud-cover data acquired during the solar eclipse of 20 March 2015 from 76 UK Met Office weather stations, and compare the results with those from 30 weather stations in the Faroe Islands and 148 stations in Iceland. There was a statistically significant mean UK temperature drop of 0.83±0.63°C, which occurred over 39 min on average, and the minimum temperature lagged the peak of the eclipse by about 10 min. For a subset of 14 (16) relatively clear (cloudy) stations, the mean temperature drop was 0.91±0.78 (0.31±0.40)°C but the mean temperature drops for relatively calm and windy stations were almost identical. Mean wind speed dropped significantly by 9% on average during the first half of the eclipse. There was no discernible effect of the eclipse on the wind-direction or MSLP time series, and therefore we can discount any localized eclipse cyclone effect over Britain during this event. Similar changes in air temperature and wind speed are observed for Iceland, where conditions were generally clearer, but here too there was no evidence of an eclipse cyclone; in the Faroes, there was a much more muted meteorological signature.This article is part of the themed issue 'Atmospheric effects of solar eclipses stimulated by the 2015 UK eclipse'.

  2. Evaluation of the UK Met Office's HadGEM3-RA and HadRM3P regional climate models within South America-CORDEX simulations: ENSO related interannual precipitation variability

    NASA Astrophysics Data System (ADS)

    Bozkurt, D.; Rojas, M.

    2014-12-01

    This study aims to investigate and compare the ability of the UK Met Office's HadGEM3-RA and HadRM3P regional climate models (RCMs) to simulate mean and interannual variability of precipitation over South America with a special focus on Chile. The HadGEM3-RA is a regional version of the newly developed HadGEM3 global model and the HadRM3P is based on the earlier HadCM3 global model. The RCMs simulations were carried out at 0.44o x 0.44o degree resolution over South America-CORDEX domain for the period 1989-2008. The initial and boundary conditions were provided by ERA-Interim Reanalysis data available at 6-h intervals with a resolution of 1.5o x 1.5o in the horizontal and 37 pressure levels. We compare the results against a number of observational datasets, including gridded dataset of CRU, UDEL, TRMM and GPCP. Moreover, available station data is derived from Direccion General de Aguas (DGA) mainly for Central Chile, which is the heartland of Chile with the highest population and important economic activities. The analysis is mainly focused on evaluating the abilities of the RCMs in simulating spatial pattern and ENSO related precipitation variability in different subregions of South America-CORDEX domain. In general, both RCMs have a good skill in reproducing spatial pattern and annual cycle of observed precipitation in climatically different subregions. However, both RCMs tend to underestimate precipitation in the Amazon Basin, which is more pronounced in the HadRM3P simulations. On the contrary, the RCMs tend to overestimate the precipitation over the Andes and southern Chile. The overestimation could be related to the physical core of the RCMs, but the discrepancies could also arise due to insufficient station network, especially in the mountainous areas, potentially yielding smaller precipitation quantities in the observed data than the true ones. In terms of interannual variability, the models capture ENSO related wet and dry interannual precipitation

  3. MET ONE 831

    EPA Science Inventory

    The Met One 831 sensor measures particulate matter (PM) by counting and sizing individual particles using scattered laser light. The unit then converts the count data to mass measurements in micrograms per cubic meter (µg/m3). The Met One 831 counts particles in four different PM...

  4. MET ONE 831

    EPA Science Inventory

    The Met One 831 sensor measures particulate matter (PM) by counting and sizing individual particles using scattered laser light. The unit then converts the count data to mass measurements in micrograms per cubic meter (µg/m3). The Met One 831 counts particles in four different PM...

  5. Perspectives of Central Office Staff, Principals, Teachers, and School Site Councils on Resource Allocation and "Budgeting for Student Achievement" Implementation in 2010-11. A Report Prepared for the Los Angeles Unified School District

    ERIC Educational Resources Information Center

    Haxton, Clarisse L.; Chambers, Jay G.; Manship, Karen; Cruz, Lisa; O'Neil, Caitlin

    2012-01-01

    As part of the evaluation of the Strategic School Funding for Results (SSFR) project (called Budgeting for Student Success, or BSA, in Los Angeles Unified School District), the American Institutes for Research (AIR) conducted surveys of principals, teachers, and members of School Site Councils (SSCs) to gather information on their attitudes and…

  6. Perspectives of Key Central Office Staff and School Principals Regarding Resource Allocation Policies and Procedures. A Report Prepared for Los Angeles Unified School District. SSFR Research Report #02 (LAUSD)

    ERIC Educational Resources Information Center

    Chambers, Jay G.; Jubb, Steve; Manship, Karen; Rosas, Rigo; Brown, James R.

    2010-01-01

    This report summarizes the perspectives and attitudes of a selected set of district and school site administrators whom the authors interviewed in Los Angeles Unified School District (LAUSD) during the fall and winter of the 2009-2010 school year. The authors carried out interviews with selected district administrators and a series of focus groups…

  7. Perspectives of Key Central Office Staff and School Principals Regarding Resource Allocation Policies and Procedures--Technical Appendix. A Report Prepared for Twin Rivers Unified School District. SSFR Research Report #02 (TRUSD)

    ERIC Educational Resources Information Center

    Chambers, Jay G.; Brown, James R.; Tolleson, Ray; Manship, Karen; Knudson, Joel

    2010-01-01

    Strategic School Funding for Results (SSFR) interviews in Twin Rivers Unified School District (TRUSD) took place in October 2009. Three key district officials were interviewed, and five principals (representing elementary, middle, and high schools) participated in a focus group. District officials were chosen for interviews because of their key…

  8. Perspectives of Key Central Office Staff and School Principals Regarding Resource Allocation Policies and Procedures. A Report Prepared for Twin Rivers Unified School District. SSFR Research Report #02 (TRUSD)

    ERIC Educational Resources Information Center

    Chambers, Jay G.; Brown, James R.; Tolleson, Ray; Manship, Karen; Knudson, Joel

    2010-01-01

    This report summarizes the perspectives and attitudes of a selected set of district and school site administrators whom the authors interviewed in Twin Rivers Unified School District (TRUSD) during the fall of 2009. The authors carried out interviews and focus groups with these individuals to gain an understanding of how the current budgeting…

  9. Carnap on unified science.

    PubMed

    Klev, Ansten

    2016-10-01

    Unified science is a recurring theme in Carnap's work from the time of the Aufbau until the end of the 1930's. The theme is not constant, but knows several variations. I shall extract three quite precise formulations of the thesis of unified science from Carnap's work during this period: from the Aufbau, from Carnap's so-called syntactic period, and from Testability and Meaning and related papers. My main objective is to explain these formulations and to discuss their relation, both to each other and to other aspects of Carnap's work.

  10. Unified tensile fracture criterion.

    PubMed

    Zhang, Z F; Eckert, J

    2005-03-11

    We find that the classical failure criteria, i.e., maximum normal stress criterion, Tresca criterion, Mohr-Coulomb criterion, and von Mises criterion, cannot satisfactorily explain the tensile fracture behavior of the bulk metallic glass (BMG) materials. For a better description, we propose an ellipse criterion as a new failure criterion to unify the four classical criteria above and apply it to exemplarily describe the tensile fracture behavior of BMGs as well as a variety of other materials. It is suggested that each of the classical failure criteria can be unified by the present ellipse criterion depending on the difference of the ratio alpha=tau(0)/sigma(0).

  11. Soar and the case for unified theories of cognition.

    PubMed

    Cooper, R; Shallice, T

    1995-05-01

    Despite the potential importance to cognitive psychology of unified theories no attempt has been made to assess concretely the methodological problems that such theorising produces. This paper addresses this issue of unified theorising, and in particular the arguments for unified theories put forward by Newell (1990). Close examination of these arguments reveals that Newell's approach does not adequately counter the difficulties which beset the grand theories of the 1930s, nor the problems of irrelevant specification which arise in modern computational psychological work. These difficulties do not prevent the development of unified theories, but they do pose serious problems, problems which it is argued can only be met by rigorous empirical testing together with extreme methodological sensitivity. The methodological concerns lead us to examine Soar, perhaps the most well-developed unified theory, from methodological, computational, and empirical perspectives. Our conclusions are that, whilst Soar represents an impressive body of research, its methodological foundations are insecure, it is ill specified as a computational/psychological theory, and under empirical testing it does not stand up to close scrutiny as a unified theory. The Soar research programme as it currently stands thus fails to meet the necessary methodological demands imposed by unified theorising.

  12. Outdoor Unified Studies.

    ERIC Educational Resources Information Center

    Liston, Louise

    Escalante (Utah) High School's outdoor unified studies field trip is a learning experience to be remembered. The four-day camping experience begins with pre-trip plans, pretests, and lecture/introductions to the Anasazi culture and to geologic formations to be visited. Horses (and equipment-carrying trucks) take the students into the desert to set…

  13. 34 CFR 650.34 - What conditions must be met by fellows?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 3 2013-07-01 2013-07-01 false What conditions must be met by fellows? 650.34 Section 650.34 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF... By Fellows? § 650.34 What conditions must be met by fellows? In order to continue to receive...

  14. 34 CFR 650.34 - What conditions must be met by fellows?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 3 2014-07-01 2014-07-01 false What conditions must be met by fellows? 650.34 Section 650.34 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF... By Fellows? § 650.34 What conditions must be met by fellows? In order to continue to receive...

  15. 34 CFR 650.34 - What conditions must be met by fellows?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 3 2011-07-01 2011-07-01 false What conditions must be met by fellows? 650.34 Section 650.34 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF... By Fellows? § 650.34 What conditions must be met by fellows? In order to continue to receive...

  16. 34 CFR 650.34 - What conditions must be met by fellows?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 3 2012-07-01 2012-07-01 false What conditions must be met by fellows? 650.34 Section 650.34 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF... By Fellows? § 650.34 What conditions must be met by fellows? In order to continue to receive...

  17. 41 CFR 109-25.104 - Acquisition of office furniture and office machines.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... furniture and office machines. 109-25.104 Section 109-25.104 Public Contracts and Property Management... furniture and office machines. DOE offices and designated contractors shall make the determination as to whether requirements can be met through the utilization of DOE owned furniture and office machines....

  18. 41 CFR 109-25.104 - Acquisition of office furniture and office machines.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... furniture and office machines. 109-25.104 Section 109-25.104 Public Contracts and Property Management... furniture and office machines. DOE offices and designated contractors shall make the determination as to whether requirements can be met through the utilization of DOE owned furniture and office machines....

  19. 41 CFR 109-25.104 - Acquisition of office furniture and office machines.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... furniture and office machines. 109-25.104 Section 109-25.104 Public Contracts and Property Management... furniture and office machines. DOE offices and designated contractors shall make the determination as to whether requirements can be met through the utilization of DOE owned furniture and office machines....

  20. 41 CFR 109-25.104 - Acquisition of office furniture and office machines.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... furniture and office machines. 109-25.104 Section 109-25.104 Public Contracts and Property Management... furniture and office machines. DOE offices and designated contractors shall make the determination as to whether requirements can be met through the utilization of DOE owned furniture and office machines....

  1. 41 CFR 109-25.104 - Acquisition of office furniture and office machines.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... furniture and office machines. 109-25.104 Section 109-25.104 Public Contracts and Property Management... furniture and office machines. DOE offices and designated contractors shall make the determination as to whether requirements can be met through the utilization of DOE owned furniture and office machines....

  2. Department of Education Revives Civil Rights Office

    ERIC Educational Resources Information Center

    Finkel, Ed

    2010-01-01

    This article reports on the mission of the Office for Civil Rights in the U.S. Department of Education to ensure equal access to education through compliance reviews. The Office hopes to use these reviews to provide technical assistance to help districts improve their performance. In late March, the Los Angeles Unified School District became the…

  3. Department of Education Revives Civil Rights Office

    ERIC Educational Resources Information Center

    Finkel, Ed

    2010-01-01

    This article reports on the mission of the Office for Civil Rights in the U.S. Department of Education to ensure equal access to education through compliance reviews. The Office hopes to use these reviews to provide technical assistance to help districts improve their performance. In late March, the Los Angeles Unified School District became the…

  4. The Unified Astronomy Thesaurus

    NASA Astrophysics Data System (ADS)

    Erdmann, Christopher; Frey, Katie

    2015-08-01

    The Unified Astronomy Thesaurus (UAT) is an open, interoperable and community-supported thesaurus which unifies the existing divergent and isolated Astronomy & Astrophysics vocabularies into a single high-quality, freely-available open thesaurus formalizing astronomical concepts and their inter-relationships. The UAT builds upon both the International Astronomical Union Thesaurus and the International Virtual Observatory Alliance Thesaurus with major contributions from the astronomy portions of the thesauri developed by the Institute of Physics Publishing, the American Institute of Physics, and SPIE, donated to the American Astronomical Society (AAS). In this talk, I will describe the effort behind the creation of the UAT, its continued development through the leadership of the AAS, and discuss some of its current and potential applications.

  5. The unified method rules

    SciTech Connect

    Juric, R.

    1996-12-31

    Any methodology for information systems development defines rules and conditions that are to be followed and satisfied when applying it to developing analysis and design models of a system. The newest attempt to achieve a successful systems development and establish standards in object oriented analysis and design technologies resulted in the unified method documentation set, version 0.8 being published in late 1995. In this paper I will analyse the first draft and present a set of rules that must be satisfied by the valid unified method. The rules are divided into different sections: (A) classes/objects and categories, (B) attributes and operations, (C) associations and inheritance, (D) message trace diagram/object message diagram/state diagram/use cases.

  6. Unified powered flight guidance

    NASA Technical Reports Server (NTRS)

    Brand, T. J.; Brown, D. W.; Higgins, J. P.

    1973-01-01

    A complete revision of the orbiter powered flight guidance scheme is presented. A unified approach to powered flight guidance was taken to accommodate all phases of exo-atmospheric orbiter powered flight, from ascent through deorbit. The guidance scheme was changed from the previous modified version of the Lambert Aim Point Maneuver Mode used in Apollo to one that employs linear tangent guidance concepts. This document replaces the previous ascent phase equation document.

  7. Unified Database Development Program.

    DTIC Science & Technology

    1984-03-01

    unified database (UDB) program was to develop an automated system that would be useful to those responsible for the design , development, testing, and...weapon system design . Baekgound The Air Force is concerned with the lack of adequate logistics consideration during the weapon system design process. To...produce a weapon system with optimal cost and mission effectiveness, logistics factors must be considered very early and throughout the system design

  8. Unified Engineering Software System

    NASA Technical Reports Server (NTRS)

    Purves, L. R.; Gordon, S.; Peltzman, A.; Dube, M.

    1989-01-01

    Collection of computer programs performs diverse functions in prototype engineering. NEXUS, NASA Engineering Extendible Unified Software system, is research set of computer programs designed to support full sequence of activities encountered in NASA engineering projects. Sequence spans preliminary design, design analysis, detailed design, manufacturing, assembly, and testing. Primarily addresses process of prototype engineering, task of getting single or small number of copies of product to work. Written in FORTRAN 77 and PROLOG.

  9. 78 FR 71708 - Sunshine Act Meeting; Unified Carrier Registration Plan Board of Directors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-29

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Federal Motor Carrier Safety Administration Sunshine Act Meeting; Unified Carrier Registration Plan Board of Directors AGENCY: Federal Motor Carrier Safety Administration (FMCSA), DOT. ACTION: Notice...

  10. 78 FR 77773 - Sunshine Act Meetings; Unified Carrier Registration Plan Board of Directors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-24

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Federal Motor Carrier Safety Administration Sunshine Act Meetings; Unified Carrier Registration Plan Board of Directors AGENCY: Federal Motor Carrier Safety Administration (FMCSA), DOT. ACTION: Notice...

  11. 78 FR 18235 - Unified Rule for Loss on Subsidiary Stock

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-26

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE TREASURY Internal Revenue Service 26 CFR Part 1 Unified Rule for Loss on Subsidiary Stock CFR Correction 0 In Title 26 of the Code of Federal Regulations, Part 1 (Sec. Sec. 1.1401 to 1.1550), revised as of April...

  12. 78 FR 18235 - Unified Rule for Loss on Subsidiary Stock

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-26

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE TREASURY Internal Revenue Service 26 CFR Part 1 Unified Rule for Loss on Subsidiary Stock CFR Correction 0 In Title..., the preferred stock is treated as entitled to a distribution no later than the time the...

  13. MET deregulation in breast cancer

    PubMed Central

    Landi, Lorenza

    2015-01-01

    Background Mesenchymal-epithelial transition (MET) is an oncogene encoding for a trans-membrane tyrosine kinase receptor activated by the hepatocyte growth factor (HGF). MET has a normal function in organ development during embryogenesis and in tissue homeostasis during adult life. Deregulation of HGF/MET signaling pathway is frequently observed in many cancer types, conferring invasive growth and tendency to progression. MET deregulation is due to gene amplification or increased copy number, gene mutation, receptor over-expression or ligand autocrine loops activation. These events lead to migration, invasion, proliferation, metastatic spread and neo-angiogenesis of cancer cells, suggesting that anti-HGF/MET agents may represent a potential antitumor strategy. In breast cancer (BC), preclinical and clinical data demonstrated the role of HGF/MET signalling pathway in carcinogenesis, disease progression and resistance features. Methods For this review article, all published data on HGF/MET in BC were collected and analyzed. Results Several evidences underline that, in early BC, MET over-expression has an independent negative prognostic significance, regardless of method used for evaluation and BC subtypes. Available data suggest that MET is a relevant target particularly in basal-like (BL) and in triple negative BC. Moreover, preclinical and retrospective data support the critical role of MET deregulation in the development of resistance to target-agents, such as anti-HER2 strategies. Conclusions MET is a promising new target in BC. Several anti-MET agents are under investigation and ongoing clinical trials will clarify its relevance in BC treatment. PMID:26366398

  14. Characterizing the roles of Met31 and Met32 in coordinating Met4-activated transcription in the absence of Met30

    PubMed Central

    Carrillo, Emilio; Ben-Ari, Giora; Wildenhain, Jan; Tyers, Mike; Grammentz, Dilon; Lee, Traci A.

    2012-01-01

    Yeast sulfur metabolism is transcriptionally regulated by the activator Met4. Met4 lacks DNA-binding ability and relies on interactions with Met31 and Met32, paralogous proteins that bind the same cis-regulatory element, to activate its targets. Although Met31 and Met32 are redundant for growth in the absence of methionine, studies indicate that Met32 has a prominent role over Met31 when Met30, a negative regulator of Met4 and Met32, is inactive. To characterize different roles of Met31 and Met32 in coordinating Met4-activated transcription, we examined transcription in strains lacking either Met31 or Met32 upon Met4 induction in the absence of Met30. Microarray analysis revealed that transcripts involved in sulfate assimilation and sulfonate metabolism were dramatically decreased in met32Δ cells compared to its wild-type and met31Δ counterparts. Despite this difference, both met31Δ and met32Δ cells used inorganic sulfur compounds and sulfonates as sole sulfur sources in minimal media when Met30 was present. This discrepancy may be explained by differential binding of Met31 to Cbf1-dependent promoters between these two conditions. In the absence of Met30, genome-wide chromatin immunoprecipitation analyses found that Met32 bound all Met4-bound targets, supporting Met32 as the main platform for Met4 recruitment. Finally, Met31 and Met32 levels were differentially regulated, with Met32 levels mimicking the profile for active Met4. These different properties of Met32 likely contribute to its prominent role in Met4-activated transcription when Met30 is absent. PMID:22438580

  15. Evaluation of high-resolution MetUM and AMPS forecasts of near-surface meteorological variables over Larsen C ice shelf and northern Antarctic Peninsula

    NASA Astrophysics Data System (ADS)

    Orr, Andrew; Kirchgaessner, Amelie; King, John; Weeks, Mark; Gadian, Alan; Kuipers Munneke, Peter; van den Broeke, Michiel; Steffen, Konrad

    2016-04-01

    High-resolution weather forecasts are an important tool for understanding the detailed patterns of surface melt on the Larsen C ice shelf (LCIS), Antarctic Peninsula. We investigate the skill of UK Met Office Unified Model (MetUM) and Antarctic Mesoscale Prediction System (AMPS) forecasts with horizontal grid spacing of 4-5 km for a 1 month period during January-February 2011 by comparing near-surface model output to automatic weather station measurements at 5 sites on the LCIS and 3 on the northern Antarctic Peninsula. Forecasts for the range 12-24 h showed a fairly homogeneous performance over the LCIS. The 2 m temperature simulated by AMPS has a correlation with observations of 0.5-0.6 and a systematic cold bias of around -1 degrees centigrade. By comparison, the MetUM had a higher correlation and was less negatively biased. The simulated surface pressure has a correlation of 0.99 and small biases in both models. AMPS yielded better results than the MetUM for 10 m wind speed, being able to capture particularly well synoptically-driven high wind speeds which the MetUM systematically underestimated. Both models struggle to simulate the 10 m wind direction when the wind conditions are highly variable. The simulation of specific humidity by both models was poor. Both models showed a general reduction in performance over the northern Antarctic Peninsula compared to the LCIS. Extending the analysis to consider the 12-36 h forecast range demonstrated a relatively weak dependence of model skill to the length of the forecast. The study focuses particularly on the representation of foehn wind events, which are an important contributor to surface melt over the LCIS, by examining additional ~1 km scale forecasts using the MetUM.

  16. Unified Bohm criterion

    SciTech Connect

    Kos, L.; Tskhakaya, D. D.; Jelić, N.

    2015-09-15

    Recent decades have seen research into the conditions necessary for the formation of the monotonic potential shape in the sheath, appearing at the plasma boundaries like walls, in fluid, and kinetic approximations separately. Although either of these approaches yields a formulation commonly known as the much-acclaimed Bohm criterion (BC), the respective results involve essentially different physical quantities that describe the ion gas behavior. In the fluid approach, such a quantity is clearly identified as the ion directional velocity. In the kinetic approach, the ion behavior is formulated via a quantity (the squared inverse velocity averaged by the ion distribution function) without any clear physical significance, which is, moreover, impractical. In the present paper, we try to explain this difference by deriving a condition called here the Unified Bohm Criterion, which combines an advanced fluid model with an upgraded explicit kinetic formula in a new form of the BC. By introducing a generalized polytropic coefficient function, the unified BC can be interpreted in a form that holds, irrespective of whether the ions are described kinetically or in the fluid approximation.

  17. Analysis and reduction of tropical systematic errors through a unified modelling strategy

    NASA Astrophysics Data System (ADS)

    Copsey, D.; Marshall, A.; Martin, G.; Milton, S.; Senior, C.; Sellar, A.; Shelly, A.

    2009-04-01

    Systematic errors in climate models are usually addressed in a number of ways, but current methods often make use of model climatological fields as a starting point for model modification. This approach has limitations due to non-linear feedback mechanisms which occur over longer timescales and make the source of the errors difficult to identify. In a unified modelling environment, short-range (1-5 day) weather forecasts are readily available from NWP models with very similar dynamical and physical formulations to the climate models, but often increased horizontal (and vertical) resolution. Where such forecasts exhibit similar systematic errors to their climate model counterparts, there is much to be gained from combined analysis and sensitivity testing. For example, the Met Office Hadley Centre climate model HadGEM1 (Johns et al 2007) exhibits precipitation errors in the Asian summer monsoon, with too little rainfall over the Indian peninsula and too much over the equatorial Indian Ocean to the southwest of the peninsula (Martin et al., 2004). Examination of the development of precipitation errors in the Asian summer monsoon region in Met Office NWP forecasts shows that different parts of the error pattern evolve on different timescales. Excessive rainfall over the equatorial Indian Ocean to the southwest of the Indian peninsula develops rapidly, over the first day or two of the forecast, while a dry bias over the Indian land area takes ~10 days to develop. Such information is invaluable for understanding the processes involved and how to tackle them. Other examples of the use of this approach will be discussed, including analysis of the sensitivity of the representation of the Madden-Julian Oscillation (MJO) to the convective parametrisation, and the reduction of systematic tropical temperature and moisture biases in both climate and NWP models through improved representation of convective detrainment.

  18. ASI/MET - 3-D

    NASA Image and Video Library

    1997-07-13

    The Atmospheric Structure Instrument/Meteorology Package ASI/MET is the mast and windsocks at the center of this stereo image from NASA Mars Pathfinder. 3D glasses are necessary to identify surface detail.

  19. Shall Organized Medicine be Unified, or Separate?

    PubMed Central

    1971-01-01

    At present, physicians in California who choose to join organized medicine do so through their county medical societies, and membership in the California Medical Association and the American Medical Association is then automatic. At the March meeting of the CMA House of Delegates, question was raised whether membership in CMA, and the AMA, or both should remain automatic. The House requested an ad hoc committee to cause a “poll and its attendant statements to be developed by May 21 for copy distribution to component medical societies and printing in the CMA membership news media—with mailing of the official questionnaires to the society members on September 1, 1971.” Members will be asked to express their opinions by ballot in September. The Speaker of the House appointed an ad hoc committee of the House to conduct this informed opinion poll of the membership. The committee has met to set ground rules, prepare accurate pro and con statements and write the poll questions—in accord with the directions of the House action. The Informed Membership Opinion Poll Committee, with the advice of Decision Making Information, Inc., an independent consultant, prepared statements regarding unified and separate membership in CMA and AMA from comments which were solicited from every county medical society. A statement by legal counsel for the California Medical Association on the structural relationship of AMA, CMA and component societies, and the statements on unified or separate membership prepared by the committee appear on the following two pages. PMID:18730549

  20. LCLS Heavy Met Outgassing Tests

    SciTech Connect

    Kishiyama, K. I.

    2010-12-01

    A Heavy Met that is 95% tungsten, 3% nickel and 2% iron and sintered to 100% density and is Ultra High Vacuum (UHV) compatible is proposed for use as the X-ray slit in the Front End Enclosure and the Fixed Mask for the Linac Coherent Light Source (LCLS). The Heavy Met was tested in the LLNL Vacuum Sciences and Engineering Lab (VSEL) to determine its outgassing rate and its overall compatibility with the vacuum requirements for LCLS.

  1. MET — EDRN Public Portal

    Cancer.gov

    From NCBI Gene: The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008

  2. Microcomputers in the Research Office.

    ERIC Educational Resources Information Center

    Daly, Brian E.

    There are three valuable types of computer software needed by the professional researcher--word processing, spreadsheet, and database management. In general, these packages are required for the effective operation of offices; however, researchers may have special needs which can only be met with more specialized software. Recently, word processing…

  3. Microcomputers in the Research Office.

    ERIC Educational Resources Information Center

    Daly, Brian E.

    There are three valuable types of computer software needed by the professional researcher--word processing, spreadsheet, and database management. In general, these packages are required for the effective operation of offices; however, researchers may have special needs which can only be met with more specialized software. Recently, word processing…

  4. Unitary or unified taxonomy?

    PubMed Central

    Scoble, Malcolm J

    2004-01-01

    Taxonomic data form a substantial, but scattered, resource. The alternative to such a fragmented system is a 'unitary' one of preferred, consensual classifications. For effective access and distribution the (Web) revision for a given taxon would be established at a single Internet site. Although all the international codes of nomenclature currently preclude the Internet as a valid medium of publication, elements of unitary taxonomy (UT) still exist in the paper system. Much taxonomy, unitary or not, already resides on the Web. Arguments for and against adopting a unitary approach are considered and a resolution is attempted. Rendering taxonomy essentially Web-based is as inevitable as it is desirable. Apparently antithetical to the UT proposal is the view that in reality multiple classifications of the same taxon exist, since different taxonomists often hold different concepts of their taxa: a single name may apply to many different (frequently overlapping) circumscriptions and more than one name to a single taxon. However, novel means are being developed on single Internet sites to retain the diversity of multiple concepts for taxa, providing hope that taxonomy may become established as a Web-based information discipline that will unify the discipline and facilitate data access. PMID:15253355

  5. Factors associated with metabolic syndrome among Korean office workers.

    PubMed

    Ryu, Hosihn; Chin, Dal Lae

    2017-09-03

    To assess the prevalence of metabolic syndrome (MetS) and identify risk factors associated with MetS among Korean office workers, this cross-sectional study was conducted with 776 office workers. The prevalence of MetS was 13.5%; elevated waist circumference (27.5%), elevated fasting glucose (23.1%), elevated triglycerides (22.2%), low high-density lipoprotein cholesterol (HDL-C) (13.4%), and elevated BP (9.4%). Having any medical health problems (OR = 3.98, 95% CI: 2.01-7.85), more knowledge of MetS (OR = 1.26, 95% CI: 1.02-1.56), higher BMI (OR = 1.42, 95% CI: 1.30-1.57), current smoking (OR = 3.78, 95% CI: 1.04-13.73), and physical inactivity (OR = 3.22, 95% CI: 1.21-8.58) were significantly associated with increased likelihood of MetS. Addressing the influence of these factors on MetS could lead to the development of workplace-based intervention strategies to encourage lifestyle changes and prevent the risk of MetS among Korean office workers.

  6. CUE: the continuous unified electronic diary method.

    PubMed

    Ellis-Davies, Kate; Sakkalou, Elena; Fowler, Nia C; Hilbrink, Elma E; Gattis, Merideth

    2012-12-01

    In the present article, we introduce the continuous unified electronic (CUE) diary method, a longitudinal, event-based, electronic parent report method that allows real-time recording of infant and child behavior in natural contexts. Thirty-nine expectant mothers were trained to identify and record target behaviors into programmed handheld computers. From birth to 18 months, maternal reporters recorded the initial, second, and third occurrences of seven target motor behaviors: palmar grasp, rolls from side to back, reaching when sitting, pincer grip, crawling, walking, and climbing stairs. Compliance was assessed as two valid entries per behavior: 97 % of maternal reporters met compliance criteria. Reliability was assessed by comparing diary entries with researcher assessments for three of the motor behaviors: palmar grasp, pincer grip and walking. A total of 81 % of maternal reporters met reliability criteria. For those three target behaviors, age of emergence was compared across data from the CUE diary method and researcher assessments. The CUE diary method was found to detect behaviors earlier and with greater sensitivity to individual differences. The CUE diary method is shown to be a reliable methodological tool for studying processes of change in human development.

  7. 76 FR 76623 - Connect America Fund; Developing a Unified Intercarrier Compensation Regime

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-08

    ... and rate-of-return incumbent local exchange carriers (LECs) to refile their interstate switched access tariffs at lower rates if the following two conditions are met: (1) A LEC has a revenue sharing agreement.... 10-208, FCC 11-161] Connect America Fund; Developing a Unified Intercarrier Compensation...

  8. 34 CFR 373.23 - What additional requirements must be met?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false What additional requirements must be met? 373.23 Section 373.23 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION SPECIAL DEMONSTRATION PROGRAMS What...

  9. 34 CFR 692.21 - What requirements must be met by a State program?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 4 2013-07-01 2013-07-01 false What requirements must be met by a State program? 692.21 Section 692.21 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION (CONTINUED) LEVERAGING EDUCATIONAL...

  10. 34 CFR 692.101 - What requirements must be met by a State partnership?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 4 2012-07-01 2012-07-01 false What requirements must be met by a State partnership? 692.101 Section 692.101 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION (CONTINUED) LEVERAGING EDUCATIONAL...

  11. 34 CFR 692.101 - What requirements must be met by a State partnership?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 4 2014-07-01 2014-07-01 false What requirements must be met by a State partnership? 692.101 Section 692.101 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION (CONTINUED) LEVERAGING EDUCATIONAL...

  12. 34 CFR 692.101 - What requirements must be met by a State partnership?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What requirements must be met by a State partnership? 692.101 Section 692.101 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION LEVERAGING EDUCATIONAL ASSISTANCE...

  13. 34 CFR 692.101 - What requirements must be met by a State partnership?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 4 2011-07-01 2011-07-01 false What requirements must be met by a State partnership? 692.101 Section 692.101 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION (CONTINUED) LEVERAGING EDUCATIONAL...

  14. 34 CFR 692.101 - What requirements must be met by a State partnership?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 4 2013-07-01 2013-07-01 false What requirements must be met by a State partnership? 692.101 Section 692.101 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION (CONTINUED) LEVERAGING EDUCATIONAL...

  15. Designers' unified cost model

    NASA Technical Reports Server (NTRS)

    Freeman, W.; Ilcewicz, L.; Swanson, G.; Gutowski, T.

    1992-01-01

    The Structures Technology Program Office (STPO) at NASA LaRC has initiated development of a conceptual and preliminary designers' cost prediction model. The model will provide a technically sound method for evaluating the relative cost of different composite structural designs, fabrication processes, and assembly methods that can be compared to equivalent metallic parts or assemblies. The feasibility of developing cost prediction software in a modular form for interfacing with state-of-the-art preliminary design tools and computer aided design programs is being evaluated. The goal of this task is to establish theoretical cost functions that relate geometric design features to summed material cost and labor content in terms of process mechanics and physics. The output of the designers' present analytical tools will be input for the designers' cost prediction model to provide the designer with a database and deterministic cost methodology that allows one to trade and synthesize designs with both cost and weight as objective functions for optimization. This paper presents the team members, approach, goals, plans, and progress to date for development of COSTADE (Cost Optimization Software for Transport Aircraft Design Evaluation).

  16. Application of MET for the validation of satellite precipitation estimates

    NASA Astrophysics Data System (ADS)

    Kucera, P.; Brown, B.; Bullock, R.; Ahijevych, D.

    2009-04-01

    The goal of this study is to demonstrate the usefulness of the NCAR Model Evaluation Tools (MET) applied to the validation of high-resolution satellite rainfall estimates. MET provides grid-to-point, grid-to-grid, and advanced spatial validation techniques in one unified, modular toolkit that can be applied to a variety of spatial fields (e.g., satellite precipitation estimates). Most validation studies rely on the use of standard validation measures (mean error, bias, mean absolute error, and root mean squared error, etc.) to quantify the quality of the precipitation estimates. Often these measures indicate poorer performance because, among other things, they are unable to account for small-scale variability or discriminate types of errors such as displacement in time and/or space (location, intensity, and orientation errors, etc.) in the precipitation estimates. This issue has motivated recent research and development of many new techniques such as, but not limited to, scale decomposition, fuzzy neighborhood, and object orientated methods for evaluating spatial precipitation estimates. This study will compute statistics for high resolution satellite estimates of precipitation using standard validation measures for the comparison with object orientated measures using the MET built-in Method for Object-based Diagnostic Evaluation (MODE) algorithm using the radar-rainfall estimates as the reference. Rainfall estimates generated by the TRMM Multi-satellite precipitation analysis (TMPA) and CPC Morphing technique (CMORPH) will be used demonstrate the new validation techniques.

  17. Office automation.

    PubMed

    Arenson, R L

    1986-03-01

    By now, the term "office automation" should have more meaning for those readers who are not intimately familiar with the subject. Not all of the preceding material pertains to every department or practice, but certainly, word processing and simple telephone management are key items. The size and complexity of the organization will dictate the usefulness of electronic mail and calendar management, and the individual radiologist's personal needs and habits will determine the usefulness of the home computer. Perhaps the most important ingredient for success in the office automation arena relates to the ability to integrate information from various systems in a simple and flexible manner. Unfortunately, this is perhaps the one area that most office automation systems have ignored or handled poorly. In the personal computer world, there has been much emphasis recently on integration of packages such as spreadsheet, database management, word processing, graphics, time management, and communications. This same philosophy of integration has been applied to a few office automation systems, but these are generally vendor-specific and do not allow for a mixture of foreign subsystems. During the next few years, it is likely that a few vendors will emerge as dominant in this integrated office automation field and will stress simplicity and flexibility as major components.

  18. 75 FR 79921 - Fall 2010 Unified Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-20

    ...) FEDERAL DEPOSIT INSURANCE CORPORATION 12 CFR Ch. III Fall 2010 Unified Agenda AGENCY: Federal Deposit... Corporation (FDIC) is hereby publishing items for the Fall 2010 Unified Agenda of Federal Regulatory...

  19. 76 FR 19893 - Unified Command Plan 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-08

    ...#0;#0; ] Memorandum of April 6, 2011 Unified Command Plan 2011 Memorandum for the Secretary of... the revised Unified Command Plan. Consistent with title 10, United States Code, section 161(b)(2) and...

  20. COMT Val158Met Polymorphism Modulates Huntington's Disease Progression

    PubMed Central

    Rebeix, Isabelle; Dupoux, Emmanuel; Durr, Alexandra; Brice, Alexis; Charles, Perrine; Cleret de Langavant, Laurent; Youssov, Katia; Verny, Christophe; Damotte, Vincent; Azulay, Jean-Philippe; Goizet, Cyril; Simonin, Clémence; Tranchant, Christine; Maison, Patrick; Rialland, Amandine; Schmitz, David; Jacquemot, Charlotte; Fontaine, Bertrand; Bachoud-Lévi, Anne-Catherine

    2016-01-01

    Little is known about the genetic factors modulating the progression of Huntington’s disease (HD). Dopamine levels are affected in HD and modulate executive functions, the main cognitive disorder of HD. We investigated whether the Val158Met polymorphism of the catechol-O-methyltransferase (COMT) gene, which influences dopamine (DA) degradation, affects clinical progression in HD. We carried out a prospective longitudinal multicenter study from 1994 to 2011, on 438 HD gene carriers at different stages of the disease (34 pre-manifest; 172 stage 1; 130 stage 2; 80 stage 3; 17 stage 4; and 5 stage 5), according to Total Functional Capacity (TFC) score. We used the Unified Huntington’s Disease Rating Scale to evaluate motor, cognitive, behavioral and functional decline. We genotyped participants for COMT polymorphism (107 Met-homozygous, 114 Val-homozygous and 217 heterozygous). 367 controls of similar ancestry were also genotyped. We compared clinical progression, on each domain, between groups of COMT polymorphisms, using latent-class mixed models accounting for disease duration and number of CAG (cytosine adenine guanine) repeats. We show that HD gene carriers with fewer CAG repeats and with the Val allele in COMT polymorphism displayed slower cognitive decline. The rate of cognitive decline was greater for Met/Met homozygotes, which displayed a better maintenance of cognitive capacity in earlier stages of the disease, but had a worse performance than Val allele carriers later on. COMT polymorphism did not significantly impact functional and behavioral performance. Since COMT polymorphism influences progression in HD, it could be used for stratification in future clinical trials. Moreover, DA treatments based on the specific COMT polymorphism and adapted according to disease duration could potentially slow HD progression. PMID:27657697

  1. COMT Val158Met Polymorphism Modulates Huntington's Disease Progression.

    PubMed

    de Diego-Balaguer, Ruth; Schramm, Catherine; Rebeix, Isabelle; Dupoux, Emmanuel; Durr, Alexandra; Brice, Alexis; Charles, Perrine; Cleret de Langavant, Laurent; Youssov, Katia; Verny, Christophe; Damotte, Vincent; Azulay, Jean-Philippe; Goizet, Cyril; Simonin, Clémence; Tranchant, Christine; Maison, Patrick; Rialland, Amandine; Schmitz, David; Jacquemot, Charlotte; Fontaine, Bertrand; Bachoud-Lévi, Anne-Catherine

    Little is known about the genetic factors modulating the progression of Huntington's disease (HD). Dopamine levels are affected in HD and modulate executive functions, the main cognitive disorder of HD. We investigated whether the Val158Met polymorphism of the catechol-O-methyltransferase (COMT) gene, which influences dopamine (DA) degradation, affects clinical progression in HD. We carried out a prospective longitudinal multicenter study from 1994 to 2011, on 438 HD gene carriers at different stages of the disease (34 pre-manifest; 172 stage 1; 130 stage 2; 80 stage 3; 17 stage 4; and 5 stage 5), according to Total Functional Capacity (TFC) score. We used the Unified Huntington's Disease Rating Scale to evaluate motor, cognitive, behavioral and functional decline. We genotyped participants for COMT polymorphism (107 Met-homozygous, 114 Val-homozygous and 217 heterozygous). 367 controls of similar ancestry were also genotyped. We compared clinical progression, on each domain, between groups of COMT polymorphisms, using latent-class mixed models accounting for disease duration and number of CAG (cytosine adenine guanine) repeats. We show that HD gene carriers with fewer CAG repeats and with the Val allele in COMT polymorphism displayed slower cognitive decline. The rate of cognitive decline was greater for Met/Met homozygotes, which displayed a better maintenance of cognitive capacity in earlier stages of the disease, but had a worse performance than Val allele carriers later on. COMT polymorphism did not significantly impact functional and behavioral performance. Since COMT polymorphism influences progression in HD, it could be used for stratification in future clinical trials. Moreover, DA treatments based on the specific COMT polymorphism and adapted according to disease duration could potentially slow HD progression.

  2. Ionospheric Profiling using GPS/MET Data

    NASA Technical Reports Server (NTRS)

    Hajj, George; Romans, Larry

    1996-01-01

    A report on ionospheric profiling using GPS and MET data is presented. A description of the GPS occultation technique, some examples of GPS/MET data products, the data processing system and a preliminary validation of ionospheric profiles is discussed.

  3. Reactions of Met-Cars

    SciTech Connect

    Castleman, A.W. Jr.; Guo, B.C.

    1993-12-31

    A new class of metal-carbon complexes, termed metallo-carbohedrenes (Met-Cars), have been discovered to form in a plasma reactor in which early transition metals are vaporized into a stream carrying small hydrocarbon molecules. The initial discovery involved the species Ti{sub 8}c{sub 12}{sup +}, while subsequent studies revealed the stability of the anon and, most importantly, the neutral species. Subsequent investigations show that similar molecules, predicted to have a pentagonal dodecahedral structure, can also be formed with vanadium, hafnium, and zirconium. In the case of the latter, more recent investigations have displaced an interesting growth pattern. In particular, pentagonal dodecahedrons with dangling carbon atoms can undergo further growth, adding at least a second and third cage. The latest results on the properties and reactivities of these new cage-like molecular clusters will be discussed.

  4. Unified theory of effective interaction

    SciTech Connect

    Takayanagi, Kazuo

    2016-09-15

    We present a unified description of effective interaction theories in both algebraic and graphic representations. In our previous work, we have presented the Rayleigh–Schrödinger and Bloch perturbation theories in a unified fashion by introducing the main frame expansion of the effective interaction. In this work, we start also from the main frame expansion, and present various nonperturbative theories in a coherent manner, which include generalizations of the Brandow, Brillouin–Wigner, and Bloch–Horowitz theories on the formal side, and the extended Krenciglowa–Kuo and the extended Lee–Suzuki methods on the practical side. We thus establish a coherent and comprehensive description of both perturbative and nonperturbative theories on the basis of the main frame expansion.

  5. Unified theory of effective interaction

    NASA Astrophysics Data System (ADS)

    Takayanagi, Kazuo

    2016-09-01

    We present a unified description of effective interaction theories in both algebraic and graphic representations. In our previous work, we have presented the Rayleigh-Schrödinger and Bloch perturbation theories in a unified fashion by introducing the main frame expansion of the effective interaction. In this work, we start also from the main frame expansion, and present various nonperturbative theories in a coherent manner, which include generalizations of the Brandow, Brillouin-Wigner, and Bloch-Horowitz theories on the formal side, and the extended Krenciglowa-Kuo and the extended Lee-Suzuki methods on the practical side. We thus establish a coherent and comprehensive description of both perturbative and nonperturbative theories on the basis of the main frame expansion.

  6. Unified capacitance modelling of MOSFETs

    NASA Astrophysics Data System (ADS)

    Johannessen, O. G.; Fjeldly, T. A.; Ytterdal, T.

    1994-01-01

    A unified physics based capacitance model for MOSFETs suitable for implementation in circuit simulators is presented. This model is based on the charge conserving, so-called Meyer-like approach proposed by Turchetti et al., and utilizes a unified charge control model to assure a continuous description of the MOSFET capacitances both above and below threshold. The capacitances associated with the model are comparable to those of the well-known BSIM model in the above-threshold regime, but it is more precise in the description of near-threshold and subthreshold behaviour. Moreover, the discontinuities at the transitions between the various regimes of operation are removed. The present modelling scheme was implemented in our circuit simulator AIM-Spice, and simulations of the dynamic behaviour of various demanding benchmark circuits clearly reveal its superiority over simulations using the simple Meyer model.

  7. Recurrence theorems: A unified account

    SciTech Connect

    Wallace, David

    2015-02-15

    I discuss classical and quantum recurrence theorems in a unified manner, treating both as generalisations of the fact that a system with a finite state space only has so many places to go. Along the way, I prove versions of the recurrence theorem applicable to dynamics on linear and metric spaces and make some comments about applications of the classical recurrence theorem in the foundations of statistical mechanics.

  8. JOIDES Office

    NASA Astrophysics Data System (ADS)

    The Office of the Joint Oceanographic Institutions for Deep Earth Sampling (JOIDES), the international group of scientific institutions that gives scientific guidance to the Deep Sea Drilling Project (DSDP), will be located at the University of Miami's Rosenstiel School of Marine and Atmospheric Science from July 1, 1982, to June 30, 1984. The university is one of 15 member institutions of JOIDES; 14 of these are active, and 10 are in the United States.While JOIDES is based at the Rosenstiel School, Alan Berman, new dean of the school, will serve as chairman of the group's executive committee. Jose Honnorez, professor of marine geology at Rosenstiel, is chairman of the JOIDES planning committee. He will direct the office, which is responsible for the coordination of the planning committee and 13 advisory panels and nine working groups.

  9. Examination of Grants Awarded to the Berkeley Unified School District and to Bilingual Children's Television, Inc.

    ERIC Educational Resources Information Center

    Comptroller General of the U.S., Washington, DC.

    At the request of Congresswoman Edith Green, the Comptroller General of the United States reviewed grant procedures covering two awards made by the Office of Education (OE). The first award, made to the Berkeley Unified School District, was funded under Title VII of the Elementary and Secondary Education Act of 1965, as amended, which provides…

  10. 77 FR 745 - Revisions to the California State Implementation Plan, San Joaquin Valley Unified Air Pollution...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-06

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 52 Revisions to the California State Implementation Plan, San Joaquin Valley Unified Air Pollution Control District (SJVUAPCD) Correction In rule document 2011-33660 appearing on...

  11. SUMMER MIGRANT PROJECT, UNIFIED SCHOOL DISTRICT NUMBER 467, WICHITA COUNTY, LEOTI, KANSAS. EVALUATION REPORT.

    ERIC Educational Resources Information Center

    HARRIS, ALTON E.

    THE UNIFIED SCHOOL DISTRICT 3467 CONDUCTED A SUMMER REMEDIAL PROGRAM FOR 121 MIGRANTS AND 19 NON-MIGRANTS IN CO-OPERATION WITH THE LEOTI COMMUNITY SERVICES AND THE LOCAL OFFICE OF ECONOMIC OPPORTUNITY. THE PROJECT OFFERED A HEALTH AND FOOD SERVICE IN ADDITION TO THE EDUCATIONAL CURRICULUM. THE CURRICULUM FOR GRADES KINDERGARTEN THROUGH 6 WAS…

  12. 76 FR 17841 - Interim Change to the Military Freight Traffic Unified Rules Publication (MFTURP) No. 1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-31

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE Department of the Army Interim Change to the Military Freight Traffic Unified Rules Publication (MFTURP) No. 1 AGENCY: Department of the Army, DoD. SUMMARY: The Military Surface Deployment and...

  13. Sacramento City Unified School District Chapter 1/State Compensatory Education Handbook Series.

    ERIC Educational Resources Information Center

    Sacramento City Unified School District, CA.

    Four handbooks developed by the Consolidated Programs Department of the Sacramento City Unified School District (California) provide a means by which the multitude of federal, state, and district rules and regulations pertaining to compensatory education can be understood. The "Consolidated Programs Office Management Procedures" handbook…

  14. Transcriptional start and MetR binding sites on the Escherichia coli metH gene.

    PubMed

    Marconi, R; Wigboldus, J; Weissbach, H; Brot, N

    1991-03-29

    The 5' upstream region of the Escherichia coli metH gene has been sequenced. Primer extension analysis revealed a transcription start site at 324 bases upstream of the initiator codon. An 8 base sequence homologous to the MetR binding region on the E. coli metE gene is present 217 bp downstream of the transcription start site. Gel retardation experiments showed that purified MetR protein could bind to a 30 base oligonucleotide containing the putative MetR binding region. No "met box" was present which explains the relative lack of regulation of the expression of the metH gene by methionine.

  15. Assessing the sensitivity to horizontal resolution of Unified Model simulations of Hurricane Katrina

    NASA Astrophysics Data System (ADS)

    O'Hara, J. P.; Webster, S.

    2012-12-01

    In August 2005 Hurricane Katrina made landfall close to New Orleans with devastating consequences. It was one of the strongest storms to impact the coast of the United States and was also one of the most costly. At peak intensity, its central pressure was 902 hPa and 10 m wind speeds were 175 mph. The extreme nature of this weather system therefore makes it an ideal case study to assess the ability of the Met Office Unified Model to simulate and potentially forecast such phenomena. In this study we assess the ability of the Met Office Unified Model (UM) to simulate Hurricane Katrina at a range of horizontal resolutions. Thus a set of limited area model simulations have been performed at resolutions of 1.5 km, 4 km and 24 km. By careful implementation of the lateral boundary conditions it has been possible to (one way) nest all these simulations inside the 25 km operational global forecast model version of the UM. The configuration of the 1.5 km and 4 km models is based on the 1.5 km and 4 km models used operationally over the UK and hence convection is treated explicitly, whilst the 24 km LAM is configured in the same way as the operational global forecast model and hence convection is parametrized. The simulations are all performed on a 2400 km x 1600 km domain and are all initialised around four days prior to landfall, when the observed central pressure was close to 990 hPa. The initial data for the simulations are ERA-interim analyses with the 25 km global forecast generating hourly LBCs via a series of 24 hour long forecasts initialised from successive 12z analyses. Overall, these simulations have been configured in order to make as clean an assessment as possible of the impact of horizontal resolution on the simulation of Hurricane Katrina. In this presentation we first describe and illustrate results summarising the impact of model resolution on the simulated hurricane. Consistent with the systematic tropical cyclone behaviour of the global forecast model

  16. Unifying suspension and granular rheology.

    PubMed

    Boyer, François; Guazzelli, Élisabeth; Pouliquen, Olivier

    2011-10-28

    Using an original pressure-imposed shear cell, we study the rheology of dense suspensions. We show that they exhibit a viscoplastic behavior similarly to granular media successfully described by a frictional rheology and fully characterized by the evolution of the friction coefficient μ and the volume fraction ϕ with a dimensionless viscous number I(v). Dense suspension and granular media are thus unified under a common framework. These results are shown to be compatible with classical empirical models of suspension rheology and provide a clear determination of constitutive laws close to the jamming transition.

  17. Sedenion unified theory of gravi-electromagnetism

    NASA Astrophysics Data System (ADS)

    Chanyal, B. C.

    2014-11-01

    In this paper, we represent 16-component sedenions, the generalization of octonions, which is noncommutative space-time algebra. The sedenions is neither a composition algebra nor a division algebra because it has zero divisors. Here we have formulated the sedenionic unified potential equations, unified fields equations and unified current equations of dyons and gravito-dyons. We have developed the sedenionic unified theory of dyons and gravito-dyons in terms of two eight-potentials leading to the structural symmetry between generalized electromagnetic fields of dyons and generalized gravito-Heavisidian fields of gravito-dyons. Thus we have obtained the sedenionic form of generalized Dirac-Maxwell's equations, unified work-energy theorem (Poynting theorem), generalized unified gravi-electromagnetic force and other quantum equations of dyons and gravito-dyons in simple, compact and consistent way incorporating the non-associativity and non-commutativity of sedenion variables.

  18. Evaluating the Unified Model and JULES in a semi-arid environment

    NASA Astrophysics Data System (ADS)

    Harlow, Chawn; Brooke, Jennifer; Best, Martin; Scott, Russel; Edwards, John; Weeks, Mark

    2017-04-01

    The Met Office Unified Model (UM) has a significant cold bias in land surface temperature (LST) in semi-arid regions at global resolution, and limited area model (LAM) 4.4 km and 2.2 km configurations. Evaluation of the JULES land surface scheme has been performed for flux tower sites in the Walnut Gulch Experimental Watershed in south-eastern Arizona. Flux tower measurements have shown that JULES simulated turbulent heat fluxes are larger compared with observations (21 W m-2, May monthly average) and ground heat fluxes too small (3.5 W m-2, May monthly average). The accurate representation of the bare soil cover fraction is shown to be of particular importance, reducing biases in the sensible heat flux. Offline simulations with JULES are used to compare UM configurations with observed bare soil and vegetation parameters (surface type fractional cover, leaf area index and canopy height) in order to attribute the LST biases to some model parameter errors. JULES observed vegetation simulations increase the modelled daytime surface warming; daytime LST (O-B) biases are reduced to -0.4 K compared with 4.8 K in the standard configuration simulations when compared with ground-based IRT measurements. Similar trends are seen when the model is compared with MODIS LST retrievals; Aqua LST biases showed a large initial bias of 7.4 K with the standard configuration, reduced to 1.0 K in observed vegetation simulations. The results suggest that there is a large component of the LST bias that is due to errors in the way in which the surface energy balance of sparse vegetation is simulated by JULES. The incorrect specification of vegetation parameters, the fractional coverage of each surface type and soil hydraulic and thermal properties have all been shown to lead to errors in the prediction of surface temperatures.

  19. Unifying Memory and Database Transactions

    NASA Astrophysics Data System (ADS)

    Dias, Ricardo J.; Lourenço, João M.

    Software Transactional Memory is a concurrency control technique gaining increasing popularity, as it provides high-level concurrency control constructs and eases the development of highly multi-threaded applications. But this easiness comes at the expense of restricting the operations that can be executed within a memory transaction, and operations such as terminal and file I/O are either not allowed or incur in serious performance penalties. Database I/O is another example of operations that usually are not allowed within a memory transaction. This paper proposes to combine memory and database transactions in a single unified model, benefiting from the ACID properties of the database transactions and from the speed of main memory data processing. The new unified model covers, without differentiating, both memory and database operations. Thus, the users are allowed to freely intertwine memory and database accesses within the same transaction, knowing that the memory and database contents will always remain consistent and that the transaction will atomically abort or commit the operations in both memory and database. This approach allows to increase the granularity of the in-memory atomic actions and hence, simplifies the reasoning about them.

  20. A unified lunar control network

    NASA Technical Reports Server (NTRS)

    Davies, Merton E.; Colvin, Tim R.; Meyer, Donald L.

    1987-01-01

    Mapping network control on the Moon is composed of a number of independent regional networks. These networks frequently have different origins but never have common ties, even in overlapping areas. The objective of the unified network program is to tie the regional networks into a single consistent planetwide control network. The plan is to start with the best defined regions, create common ties with neighboring data sets, and then expand into poorly defined regions. The most accurately defined points on the Moon are locations of the laser ranging retroreflectors and the VLBI measurements of the locations of the Apollo 15, 16, 17 ALSEP stations. Recent values for the coordinates of the retroreflectors have been received. The accuracy of these locations is about 30 m and their locations are used to define the center-of-mass and, hence, the origin of the unified lunar coordinate system. The coordinates of the retroreflectors are given in both principal axis and mean Earth/Polar axis systems. Mean Earth/Polar axis coordinates have been recommended by the IAU for the Moon. The difference in the coordinates is important, more than 600 m in latitude and longitude.

  1. 75 FR 1007 - MetLife, Inc. and MetLife Capital Trust V; Notice of Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-07

    ... COMMISSION MetLife, Inc. and MetLife Capital Trust V; Notice of Application December 30, 2009. AGENCY.... Summary of Application: MetLife Capital Trust V (the ``Trust'') and MetLife, Inc. (``MetLife'') request an... and pursuant to a Declaration of Trust that MetLife signed as sponsor. As sponsor, MetLife...

  2. NARSTO EPA SS BALTIMORE JHU MET DATA

    Atmospheric Science Data Center

    2014-04-25

    NARSTO EPA SS BALTIMORE JHU MET DATA Project Title:  NARSTO ... Pyranometer Barometer Location:  Baltimore, Maryland Spatial Resolution:  Point Measurements ...   Order Data Guide Documents:  Baltimore JHU Met Guide Baltimore Project Plan  (PDF) ...

  3. Clinical significance of MET in gastric cancer

    PubMed Central

    Inokuchi, Mikito; Otsuki, Sho; Fujimori, Yoshitaka; Sato, Yuya; Nakagawa, Masatoshi; Kojima, Kazuyuki

    2015-01-01

    Chemotherapy has become the global standard treatment for patients with metastatic or unresectable gastric cancer (GC), although outcomes remain unfavorable. Many molecular-targeted therapies inhibiting signaling pathways of various tyrosine kinase receptors have been developed, and monoclonal antibodies targeting human epidermal growth factor receptor 2 or vascular endothelial growth factor receptor 2 have become standard therapy for GC. Hepatocyte growth factor and its receptor, c-MET (MET), play key roles in tumor growth through activated signaling pathways from receptor in GC cells. Genomic amplification of MET leads to the aberrant activation found in GC tumors and is related to survival in patients with GC. This review discusses the clinical significance of MET in GC and examines MET as a potential therapeutic target in patients with GC. Preclinical studies in animal models have shown that MET antibodies or small-molecule MET inhibitors suppress tumor-cell proliferation and tumor progression in MET-amplified GC cells. These drugs are now being evaluated in clinical trials as treatments for metastatic or unresectable GC. PMID:26600931

  4. Unifying physical concepts of reality

    SciTech Connect

    Gilbert, T.L.

    1983-08-01

    Physics may be characterized as the science of matter and energy. It anchors the two ends of the frontiers of science: the frontier of the very small and the frontier of the very large. All of the phenomena that we observe and study at the frontiers of science - all external experiences - are manifestations of matter and energy. One may, therefore, use physics to exemplify both the diversity and unity of science. This theme will be developed in two separate examples: first by sketching, very briefly, the historical origins of frontiers of the very small and very large and the converging unity of these two frontiers; and then by describing certain unifying concepts that play a central role in physics and provide a framework for relating developments in different sciences.

  5. Gravity and grand unified theories

    NASA Astrophysics Data System (ADS)

    Parker, L.; Toms, D. J.

    1985-02-01

    Curvature-dependent consequences of grand unified theories (GUTs) for the evolution of the very early universe are investigated, considering the possibility that at high curvature and particle energies of 10 to the 24th eV the effective values of the coupling constants governing the strength of the curvature-matter interaction are largely determined by the elementary-particle content defined by the particular GUT. The GUTs examined include those of Georgi and Glashow (1974) and Chang et al. (1980), and the coupling constants studied are the cosmological Lambda, Newtonian G, xi(phi) and xi(H) linking curvature and the scalar Higgs bosons, and alpha(i) (coefficients of action terms quadratically dependent on the curvature tensor).

  6. CONDUIT: Control Designer's Unified Interface

    NASA Technical Reports Server (NTRS)

    Levine, William S.; Tischler, Mark B.

    1999-01-01

    CONDUIT, which stands for control designer's unified interface, is a computer software package. Its purpose is to assist a human control system designer in designing control systems for aircraft. At the present time CONDUIT is being used by most of the major U. S. rotorcraft and fixed-wing aircraft manufacturers to assist in the design of stability and control augmentation systems. Work is also continuing on the development of additional features for CONDUIT, including tools for analyzing the sensitivity of solutions, and on further enhancements to the basic package. The purpose of this paper is to describe CONDUIT, its operation, and the sensitivity tools that are being developed for inclusion in the next release of the package.

  7. Prevalence, components, and correlates of metabolic syndrome (MetS) among elderly Muscovites.

    PubMed

    Metelskaya, Victoria A; Shkolnikova, Maria A; Shalnova, Svetlana A; Andreev, Evgeny M; Deev, Alexander D; Jdanov, Dmitri A; Shkolnikov, Vladimir M; Vaupel, James W

    2012-01-01

    The goal of this study is to estimate the prevalence of MetS, together with its components and correlates, among elderly Russians. Our population-based sample included randomly selected residents of Moscow aged 55 and older: 955 women with an average age of 67.6, and 833 men with an average age of 68.9. MetS was defined according to National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATPIII). The prevalence of MetS was found to be 41.7% in women and 26.8% in men. It tended to decrease with age in men, but not in women. MetS was inversely related to education in women, but not in men. The most prevalent individual components of MetS were as follows: hypertension (64.4%), abdominal obesity (55%), and decreased high density lipoprotein cholesterol (HDL C) (46%) for women; and hypertension (71%) and fasting hyperglycemia (35.2%) for men. An elevated level of triglycerides (TG) was the rarest MetS component, affecting 23.5% of women and 22.1% of men. The higher female prevalence of MetS was attributable to abdominal obesity. MetS was found to be associated with markers of insulin resistance (IR), low-grade inflammation, and insufficient fibrinolysis. Although the metabolic burden is an important contributor to high levels of ill-health and cardiovascular mortality among elderly Russians (especially women), it does not explain why cardiovascular mortality is much higher in Russia than in other industrialized countries.

  8. The Norwegian Unified School: A Paradise Lost?

    ERIC Educational Resources Information Center

    Welle-Strand, Anne; Tjeldvoll, Arild

    2002-01-01

    Explores reasons for replacement of the Unified School with the Quality School in Norway and the consequences thereof for both individuals and the country. Unified School reform is derived from an equality-driven educational policy, whereas Quality School reform is competitiveness-driven. (Contains 30 references.) (PKP)

  9. The Norwegian Unified School: A Paradise Lost?

    ERIC Educational Resources Information Center

    Welle-Strand, Anne; Tjeldvoll, Arild

    2002-01-01

    Explores reasons for replacement of the Unified School with the Quality School in Norway and the consequences thereof for both individuals and the country. Unified School reform is derived from an equality-driven educational policy, whereas Quality School reform is competitiveness-driven. (Contains 30 references.) (PKP)

  10. Science Education News, Unified Science Education.

    ERIC Educational Resources Information Center

    McCarley, Orin

    Contained are a statement of the promise of unified science education and descriptions of five unique unified science programs. Within each program the course content and rationale was stated. The five programs chosen were (1) Millburn Senior High School, (2) Saint Louis Country Day School, (3) Monona Grove High School, (4) The Portland Project,…

  11. National Symposium for Business and Office Education Curriculum Guidelines.

    ERIC Educational Resources Information Center

    Kingston, Carmela C.; Thomas, Ellis R.

    Symposium participants met to develop guidelines for developing curriculum for the area of business and office education, K through adult. The session reports are presented in outline form according to topic definition, problem areas, and recommendations. Topics discussed include: organizational patterns in the business and office education…

  12. Toward a Unified AGN Structure

    NASA Technical Reports Server (NTRS)

    Kazanas, Demosthenes; Fukumura, Keigo; Shrader, Chris; Behar, Ehud; Contopoulosa, Ioannis

    2012-01-01

    We present a unified model for the structure and appearance of accretion powered sources across their entire luminosity range from galactic X-ray binaries (XRB) to luminous quasars, with emphasis on AG N and their phenomenology. Central to this model is the notion of MHD winds launched by the accretion disks that power these objects. These winds provide the matter that manifests as blueshifted absorption features in the UV and X-ray spectra of a large fraction of these sources; furthermore, their density distribution in the poloidal plane determines their "appearance" (i.e. the column and velocity structure of these absorption features and the obscuration of the continuum source) as a function of the observer inclination angle (a feature to which INTEGRAL has made significant contributions). This work focuses on just the broadest characteristics of these objects; nonetheless, it provides scaling laws that allow one to reproduce within this model the properties of objects extending in luminosity from luminous quasars to XRBs. Our general conclusion is that the AGN phenomenology can be accounted for in terms of three parameters: The wind maSS flux in units of the Eddington value, m(dot), the observers' inclination angle Theta and the logarithmic slope between the 0/UV and X-ray fluxes alpha(sub ox); however because of a correlation between alpha(sub ox) and UV luminosity the number of significant parameters is two. The AGN correlations implied by this model appear to extend to and consistent with the XRB phenomenology, suggesting the presence of a truly unified underlying structure for accretion powered sources.

  13. 43 CFR 1810.2 - Communications by mail; when mailing requirements are met.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... requirement for mailing is met when the communication, addressed to the addressee at his last address of... received the communication if it was delivered to his last address of record in the appropriate office of... delivery which cannot be consummated at such last address of record because the addressee had moved...

  14. 43 CFR 1810.2 - Communications by mail; when mailing requirements are met.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... requirement for mailing is met when the communication, addressed to the addressee at his last address of... received the communication if it was delivered to his last address of record in the appropriate office of... delivery which cannot be consummated at such last address of record because the addressee had moved...

  15. 43 CFR 1810.2 - Communications by mail; when mailing requirements are met.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... requirement for mailing is met when the communication, addressed to the addressee at his last address of... received the communication if it was delivered to his last address of record in the appropriate office of... delivery which cannot be consummated at such last address of record because the addressee had moved...

  16. 43 CFR 1810.2 - Communications by mail; when mailing requirements are met.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Communications by mail; when mailing... GENERAL GUIDANCE General Rules § 1810.2 Communications by mail; when mailing requirements are met. (a) Where the regulations in this chapter provide for communication by mail by the authorized officer,...

  17. Arabidopsis MET1 cytosine methyltransferase mutants.

    PubMed Central

    Kankel, Mark W; Ramsey, Douglas E; Stokes, Trevor L; Flowers, Susan K; Haag, Jeremy R; Jeddeloh, Jeffrey A; Riddle, Nicole C; Verbsky, Michelle L; Richards, Eric J

    2003-01-01

    We describe the isolation and characterization of two missense mutations in the cytosine-DNA-methyltransferase gene, MET1, from the flowering plant Arabidopsis thaliana. Both missense mutations, which affect the catalytic domain of the protein, led to a global reduction of cytosine methylation throughout the genome. Surprisingly, the met1-2 allele, with the weaker DNA hypomethylation phenotype, alters a well-conserved residue in methyltransferase signature motif I. The stronger met1-1 allele caused late flowering and a heterochronic delay in the juvenile-to-adult rosette leaf transition. The distribution of late-flowering phenotypes in a mapping population segregating met1-1 indicates that the flowering-time phenotype is caused by the accumulation of inherited defects at loci unlinked to the met1 mutation. The delay in flowering time is due in part to the formation and inheritance of hypomethylated fwa epialleles, but inherited defects at other loci are likely to contribute as well. Centromeric repeat arrays hypomethylated in met1-1 mutants are partially remethylated when introduced into a wild-type background, in contrast to genomic sequences hypomethylated in ddm1 mutants. ddm1 met1 double mutants were constructed to further our understanding of the mechanism of DDM1 action and the interaction between two major genetic loci affecting global cytosine methylation levels in Arabidopsis. PMID:12663548

  18. Mars MetNet Mission Payload Overview

    NASA Astrophysics Data System (ADS)

    Harri, A.-M.; Haukka, H.; Alexashkin, S.; Guerrero, H.; Schmidt, W.; Genzer, M.; Vazquez, L.

    2012-09-01

    A new kind of planetary exploration mission for Mars is being developed in collaboration between the Finnish Meteorological Institute (FMI), Lavochkin Association (LA), Space Research Institute (IKI) and Institutio Nacional de Tecnica Aerospacial (INTA). The Mars MetNet mission [1] is based on a new semi-hard landing vehicle called MetNet Lander (MNL). The scientific payload of the Mars MetNet Precursor mission is divided into three categories: Atmospheric instruments, Optical devices and Composition and structure devices. Each of the payload instruments will provide crucial scientific data about the Martian atmospheric phenomena.

  19. Mars MetNet Precursor Mission Status

    NASA Astrophysics Data System (ADS)

    Harri, A.-M.; Aleksashkin, S.; Guerrero, H.; Schmidt, W.; Genzer, M.; Vazquez, L.; Haukka, H.

    2013-09-01

    We are developing a new kind of planetary exploration mission for Mars in collaboration between the Finnish Meteorological Institute (FMI), Lavochkin Association (LA), Space Research Institute (IKI) and Institutio Nacional de Tecnica Aerospacial (INTA). The Mars MetNet mission is based on a new semi-hard landing vehicle called MetNet Lander (MNL). The scientific payload of the Mars MetNet Precursor [1] mission is divided into three categories: Atmospheric instruments, Optical devices and Composition and structure devices. Each of the payload instruments will provide significant insights in to the Martian atmospheric behavior. The key technologies of the MetNet Lander have been qualified and the electrical qualification model (EQM) of the payload bay has been built and successfully tested.

  20. Mars MetNet Mission Status

    NASA Astrophysics Data System (ADS)

    Harri, A.-M.; Aleksashkin, S.; Arruego, I.; Schmidt, W.; Genzer, M.; Vazquez, L.; Haukka, H.; Palin, M.; Nikkanen, T.

    2015-10-01

    New kind of planetary exploration mission for Mars is under development in collaboration between the Finnish Meteorological Institute (FMI), Lavochkin Association (LA), Space Research Institute (IKI) and Institutio Nacional de Tecnica Aerospacial (INTA). The Mars MetNet mission is based on a new semihard landing vehicle called MetNet Lander (MNL). The scientific payload of the Mars MetNet Precursor [1] mission is divided into three categories: Atmospheric instruments, Optical devices and Composition and structure devices. Each of the payload instruments will provide significant insights in to the Martian atmospheric behavior. The key technologies of the MetNet Lander have been qualified and the electrical qualification model (EQM) of the payload bay has been built and successfully tested.

  1. MMPM - Mars MetNet Precursor Mission

    NASA Astrophysics Data System (ADS)

    Harri, A.-M.; Schmidt, W.; Pichkhadze, K.; Linkin, V.; Vazquez, L.; Uspensky, M.; Polkko, J.; Genzer, M.; Lipatov, A.; Guerrero, H.; Alexashkin, S.; Haukka, H.; Savijarvi, H.; Kauhanen, J.

    2008-09-01

    We are developing a new kind of planetary exploration mission for Mars - MetNet in situ observation network based on a new semi-hard landing vehicle called the Met-Net Lander (MNL). The eventual scope of the MetNet Mission is to deploy some 20 MNLs on the Martian surface using inflatable descent system structures, which will be supported by observations from the orbit around Mars. Currently we are working on the MetNet Mars Precursor Mission (MMPM) to deploy one MetNet Lander to Mars in the 2009/2011 launch window as a technology and science demonstration mission. The MNL will have a versatile science payload focused on the atmospheric science of Mars. Detailed characterization of the Martian atmospheric circulation patterns, boundary layer phenomena, and climatology cycles, require simultaneous in-situ measurements by a network of observation posts on the Martian surface. The scientific payload of the MetNet Mission encompasses separate instrument packages for the atmospheric entry and descent phase and for the surface operation phase. The MetNet mission concept and key probe technologies have been developed and the critical subsystems have been qualified to meet the Martian environmental and functional conditions. Prototyping of the payload instrumentation with final dimensions was carried out in 2003-2006.This huge development effort has been fulfilled in collaboration between the Finnish Meteorological Institute (FMI), the Russian Lavoschkin Association (LA) and the Russian Space Research Institute (IKI) since August 2001. Currently the INTA (Instituto Nacional de Técnica Aeroespacial) from Spain is also participating in the MetNet payload development. To understand the behavior and dynamics of the Martian atmosphere, a wealth of simultaneous in situ observations are needed on varying types of Martian orography, terrain and altitude spanning all latitudes and longitudes. This will be performed by the Mars MetNet Mission. In addition to the science aspects the

  2. MetNet - Martian Network Mission

    NASA Astrophysics Data System (ADS)

    Harri, A.-M.

    2009-04-01

    We are developing a new kind of planetary exploration mission for Mars - MetNet in situ observation network based on a new semi-hard landing vehicle called the Met-Net Lander (MNL). The actual practical mission development work started in January 2009 with participation from various countries and space agencies. The scientific rationale and goals as well as key mission solutions will be discussed. The eventual scope of the MetNet Mission is to deploy some 20 MNLs on the Martian surface using inflatable descent system structures, which will be supported by observations from the orbit around Mars. Currently we are working on the MetNet Mars Precursor Mission (MMPM) to deploy one MetNet Lander to Mars in the 2009/2011 launch window as a technology and science demonstration mission. The MNL will have a versatile science payload focused on the atmospheric science of Mars. Detailed characterization of the Martian atmospheric circulation patterns, boundary layer phenomena, and climatology cycles, require simultaneous in-situ measurements by a network of observation posts on the Martian surface. The scientific payload of the MetNet Mission encompasses separate instrument packages for the atmospheric entry and descent phase and for the surface operation phase. The MetNet mission concept and key probe technologies have been developed and the critical subsystems have been qualified to meet the Martian environmental and functional conditions. This development effort has been fulfilled in collaboration between the Finnish Meteorological Institute (FMI), the Russian Lavoschkin Association (LA) and the Russian Space Research Institute (IKI) since August 2001. Currently the INTA (Instituto Nacional de Técnica Aeroespacial) from Spain is also participating in the MetNet payload development.

  3. Mars MetNet Mission Status

    NASA Astrophysics Data System (ADS)

    Harri, Ari-Matti; Aleksashkin, Sergei; Arruego, Ignacio; Schmidt, Walter; Genzer, Maria; Vazquez, Luis; Haukka, Harri

    2015-04-01

    New kind of planetary exploration mission for Mars is under development in collaboration between the Finnish Meteorological Institute (FMI), Lavochkin Association (LA), Space Research Institute (IKI) and Institutio Nacional de Tecnica Aerospacial (INTA). The Mars MetNet mission is based on a new semi-hard landing vehicle called MetNet Lander (MNL). The scientific payload of the Mars MetNet Precursor [1] mission is divided into three categories: Atmospheric instruments, Optical devices and Composition and structure devices. Each of the payload instruments will provide significant insights in to the Martian atmospheric behavior. The key technologies of the MetNet Lander have been qualified and the electrical qualification model (EQM) of the payload bay has been built and successfully tested. 1. MetNet Lander The MetNet landing vehicles are using an inflatable entry and descent system instead of rigid heat shields and parachutes as earlier semi-hard landing devices have used. This way the ratio of the payload mass to the overall mass is optimized. The landing impact will burrow the payload container into the Martian soil providing a more favorable thermal environment for the electronics and a suitable orientation of the telescopic boom with external sensors and the radio link antenna. It is planned to deploy several tens of MNLs on the Martian surface operating at least partly at the same time to allow meteorological network science. 2. Scientific Payload The payload of the two MNL precursor models includes the following instruments: Atmospheric instruments: 1. MetBaro Pressure device 2. MetHumi Humidity device 3. MetTemp Temperature sensors Optical devices: 1. PanCam Panoramic 2. MetSIS Solar irradiance sensor with OWLS optical wireless system for data transfer 3. DS Dust sensor The descent processes dynamic properties are monitored by a special 3-axis accelerometer combined with a 3-axis gyrometer. The data will be sent via auxiliary beacon antenna throughout the

  4. Introduction to Grand Unified Theories

    NASA Astrophysics Data System (ADS)

    Masiero, Antonio

    The following sections are included: * THE STANDARD MODEL: A CRITICAL APPRAISAL * The "Low Energy" Limit of Renormalizable Gauge Theories * The Standard Model: its purity * The Standard Model: its impurity * Vices and Virtues of the Standard Model * INTRODUCTION TO GRAND UNIFIED THEORIES * When "Strong" and "Weak" Merge Together * The "Big Desert" Picture of the World * A Persistent Cloud: the hierarchy problem * PHENOMENOLOGICAL CONSEQUENCES OF GUTs * What is New in GUTs * General Features of the B and L Violating Processes * A FIRST GLIMPSE AT THE SU(5) MODEL * Why SU(5)? * The Higgs Sector and the Hierarchy Nightmare * LOW ENERGY PHENOMENOLOGICAL CONSEQUENCES OF SU(5) * The Successful sin2θW Prediction of SU(5) * Fermion Masses in SU(5) * Mixing Angles and Phases * Proton Lifetime: A Death Blow to the SU(5) Model? * B-L and Neutrino Masses in SU(5) * SU(5): A Final Score * NEW PHYSICS NOT FAR FROM THE FERMI SCALE? * L-Right Symmetry: A Fundamental Symmetry? * Massive Majorana Neutrinos * Neutron -Antineutron Oscillations * Lepton Number as a Fourth Colour * THE SO(10) MODEL * Few Generalities on the Orthogonal Groups * The SO(10) Gauge Interactions * Patterns of Symmetry Breaking in the SO(10) Model * The Fermion Mass Spectrum * The Question of the Neutrino Mass * PHENOMENOLOGY OF THE INTERMEDIATE MASS SCALES * Renormalization Group Equations in the Presence of IMS * MI and MX in IMS models * Higgs Contributions to the β-Functions * Phenomenological Consequences of IMS * A GENERAL OUTLOOK ON GUTs * General Constraints on GUTs * Major Unsolved Questions in GUTs * Bibliography * References

  5. Unifying evolutionary and network dynamics

    NASA Astrophysics Data System (ADS)

    Swarup, Samarth; Gasser, Les

    2007-06-01

    Many important real-world networks manifest small-world properties such as scale-free degree distributions, small diameters, and clustering. The most common model of growth for these networks is preferential attachment, where nodes acquire new links with probability proportional to the number of links they already have. We show that preferential attachment is a special case of the process of molecular evolution. We present a single-parameter model of network growth that unifies varieties of preferential attachment with the quasispecies equation (which models molecular evolution), and also with the Erdős-Rényi random graph model. We suggest some properties of evolutionary models that might be applied to the study of networks. We also derive the form of the degree distribution resulting from our algorithm, and we show through simulations that the process also models aspects of network growth. The unification allows mathematical machinery developed for evolutionary dynamics to be applied in the study of network dynamics, and vice versa.

  6. Unifying Quantum Physics with Biology

    NASA Astrophysics Data System (ADS)

    Goradia, Shantilal

    2014-09-01

    We find that the natural logarithm of the age of the universe in quantum mechanical units is close to 137. Since science is not religion, it is our moral duty to recognize the importance of this finding on the following ground. The experimentally obtained number 137 is a mystical number in science, as if written by the hand of God. It is found in cosmology; unlike other theories, it works in biology too. A formula by Boltzmann also works in both: biology and physics, as if it is in the heart of God. His formula simply leads to finding the logarithm of microstates. One of the two conflicting theories of physics (1) Einstein's theory of General Relativity and (2) Quantum Physics, the first applies only in cosmology, but the second applies in biology too. Since we have to convert the age of the universe, 13 billion years, into 1,300,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000 Planck times to get close to 137, quantum physics clearly shows the characteristics of unifying with biology. The proof of its validity also lies in its ability to extend information system observed in biology.

  7. The Unified Medical Language System

    PubMed Central

    Humphreys, Betsy L.; Lindberg, Donald A. B.; Schoolman, Harold M.; Barnett, G. Octo

    1998-01-01

    In 1986, the National Library of Medicine (NLM) assembled a large multidisciplinary, multisite team to work on the Unified Medical Language System (UMLS), a collaborative research project aimed at reducing fundamental barriers to the application of computers to medicine. Beyond its tangible products, the UMLS Knowledge Sources, and its influence on the field of informatics, the UMLS project is an interesting case study in collaborative research and development. It illustrates the strengths and challenges of substantive collaboration among widely distributed research groups. Over the past decade, advances in computing and communications have minimized the technical difficulties associated with UMLS collaboration and also facilitated the development, dissemination, and use of the UMLS Knowledge Sources. The spread of the World Wide Web has increased the visibility of the information access problems caused by multiple vocabularies and many information sources which are the focus of UMLS work. The time is propitious for building on UMLS accomplishments and making more progress on the informatics research issues first highlighted by the UMLS project more than 10 years ago. PMID:9452981

  8. Mars MetNet Mission Payload Overview

    NASA Astrophysics Data System (ADS)

    Haukka, H.; Harri, A.-M.; Alexashkin, S.; Guerrero, H.; Schmidt, W.; Genzer, M.; Vazquez, L.

    2012-04-01

    A new kind of planetary exploration mission for Mars is being developed in collaboration between the Finnish Meteorological Institute (FMI), Lavochkin Association (LA), Space Research Institute (IKI) and Institutio Nacional de Tecnica Aerospacial (INTA). The Mars MetNet mission is based on a new semi-hard landing vehicle called MetNet Lander (MNL). The main idea behind the MetNet landing vehicles is to use a state-of-the-art inflatable entry and descent system instead of rigid heat shields and parachutes as earlier semi-hard landing devices have used. This way the ratio of the payload mass to the overall mass is optimized and more mass and volume resources are spared for the science payload. The vehicle decelerates its entry speed using the inflatable structure and final landing sequence includes a cone headed body penetrating the Martian soil. It is planned to deploy several tens of MNLs on the Martian surface operating at least partly at the same time to allow meteorological network science. The payload of the two MNL precursor models includes the following instruments: Atmospheric instruments: - Pressure device (MetBaro): mass 100g, measurement range 0..1015 hPa. - Humidity device (MetHumi): mass 15g, measurement range 0..100%RH. - Temperature sensors (MetTemp): mass 2g each, measurement range -110C..+30C. Optical devices: - Panoramic camera (PanCam): mass 100g, FOV 4 lenses mounted at 90 deg - Solar irradiance sensor (MetSIS) with optical wireless system (OWLS) for data transfer: mass 115g (MetSIS) and 7g (OWLS module), wavelength range 190..1100nm. MetSIS equipped with 28 optical detectors, two temperature sensors and two solar incidence angle detectors. - Dust sensor (DS): mass 42g, resolution: 10 particles / cm3. Composition and structure device: - Magnetometer (MOURA): mass 80g, measurement range: ±30uT. MetNet Mission payload instruments are specially designed to operate in very low power conditions. MNL flexible solar panels provides a total of

  9. Associations between Police Officer Stress and the Metabolic Syndrome

    PubMed Central

    Hartley, Tara A.; Burchfiel, Cecil M.; Fekedulegn, Desta; Andrew, Michael E.; Knox, Sarah S.; Violanti, John M.

    2016-01-01

    The purpose of this study was to examine the association of police officer stress with metabolic syndrome (MetSyn) and its individual components. Participants included 288 men and 102 women from the Buffalo Cardio-Metabolic Occupational Police Stress (BCOPS) Study. Police stress was measured using the Spielberger Police Stress Survey. MetSyn was defined using 2005 guidelines. Results were stratified by gender. ANCOVA was used to describe differences in number of MetSyn components across police stress categories after adjusting for age and smoking status. Logistic regression was used to calculate odds ratios for having each MetSyn component by increased police stress levels. The multivariate-adjusted number of MetSyn components increased significantly in women across tertiles of the three perceived stress subscales, and administrative and organizational pressure and lack of support indices for the previous month. No association was found among male officers. Abdominal obesity and reduced high density lipoprotein cholesterol (HDL-C) were consistently associated with police stress in women. Police stress, particularly organizational pressure and lack of support, was associated with MetSyn among female but not male police officers. Given the stress of policing and the adverse cardiovascular disease (CVD) risk factors prevalent among police officers, exploring the association between specific types of police stress and subclinical CVD is important. PMID:22900458

  10. Connecting spatial and temporal scales of tropical precipitation in observations and the MetUM-GA6

    NASA Astrophysics Data System (ADS)

    Martin, Gill M.; Klingaman, Nicholas P.; Moise, Aurel F.

    2017-01-01

    This study analyses tropical rainfall variability (on a range of temporal and spatial scales) in a set of parallel Met Office Unified Model (MetUM) simulations at a range of horizontal resolutions, which are compared with two satellite-derived rainfall datasets. We focus on the shorter scales, i.e. from the native grid and time step of the model through sub-daily to seasonal, since previous studies have paid relatively little attention to sub-daily rainfall variability and how this feeds through to longer scales. We find that the behaviour of the deep convection parametrization in this model on the native grid and time step is largely independent of the grid-box size and time step length over which it operates. There is also little difference in the rainfall variability on larger/longer spatial/temporal scales. Tropical convection in the model on the native grid/time step is spatially and temporally intermittent, producing very large rainfall amounts interspersed with grid boxes/time steps of little or no rain. In contrast, switching off the deep convection parametrization, albeit at an unrealistic resolution for resolving tropical convection, results in very persistent (for limited periods), but very sporadic, rainfall. In both cases, spatial and temporal averaging smoothes out this intermittency. On the ˜ 100 km scale, for oceanic regions, the spectra of 3-hourly and daily mean rainfall in the configurations with parametrized convection agree fairly well with those from satellite-derived rainfall estimates, while at ˜ 10-day timescales the averages are overestimated, indicating a lack of intra-seasonal variability. Over tropical land the results are more varied, but the model often underestimates the daily mean rainfall (partly as a result of a poor diurnal cycle) but still lacks variability on intra-seasonal timescales. Ultimately, such work will shed light on how uncertainties in modelling small-/short-scale processes relate to uncertainty in climate change

  11. Operating plan for the Office of International Health Programs

    SciTech Connect

    1996-01-01

    In this report unified ideas are presented about what the Office of International Health Programs does, what the individual contributions are, and how the organization connects to the Department of Energy. The planning efforts have focused on the office`s three areas of responsibility: Europe, Japan, and the Marshall Islands. Common to each technical program area are issues related to the following: health of populations exposed to radiation incidents and the associated medical aspects of exposure; dose reconstruction; training; and public involvement. Each of the program areas, its customers, and primary customer interests are described.

  12. Toward a Unified Timestamp with explicit precision

    PubMed Central

    Benzler, Justus; Clark, Samuel J.

    2010-01-01

    Demographic and health surveillance (DS) systems monitor and document individual and group-level processes in well-defined populations over long periods of time. The resulting data are complex and inherently temporal. Established methods of storing and manipulating temporal data are unable to adequately address the challenges posed by these data. Building on existing standards, a temporal framework and notation are presented that are able to faithfully record all of the time-related information (or partial lack thereof) produced by surveillance systems. The Unified Timestamp isolates all of the inherent complexity of temporal data into a single data type and provides the foundation on which a Unified Timestamp class can be built. The Unified Timestamp accommodates both point- and interval-based time measures with arbitrary precision, including temporal sets. Arbitrary granularities and calendars are supported, and the Unified Timestamp is hierarchically organized, allowing it to represent an unlimited array of temporal entities. PMID:20396403

  13. A unified relation for cavitation erosion

    NASA Technical Reports Server (NTRS)

    Veerabhadra Rao, P.; Buckley, D. H.; Matsumura, M.

    1984-01-01

    A power-law relationship between the average erosion rate and cumulative erosion is presented. Data analyses from Venturi, magnetostriction, and liquid-impingement devices conform to this unified relation. A normalization technique is also suggested for prediction purposes.

  14. Unified universal quantum cloning machine and fidelities

    SciTech Connect

    Wang Yinan; Shi Handuo; Xiong Zhaoxi; Jing Li; Mu Liangzhu; Ren Xijun; Fan Heng

    2011-09-15

    We present a unified universal quantum cloning machine, which combines several different existing universal cloning machines together, including the asymmetric case. In this unified framework, the identical pure states are projected equally into each copy initially constituted by input and one half of the maximally entangled states. We show explicitly that the output states of those universal cloning machines are the same. One importance of this unified cloning machine is that the cloning procession is always the symmetric projection, which reduces dramatically the difficulties for implementation. Also, it is found that this unified cloning machine can be directly modified to the general asymmetric case. Besides the global fidelity and the single-copy fidelity, we also present all possible arbitrary-copy fidelities.

  15. Specification for the unified heliostat array

    SciTech Connect

    Not Available

    1980-06-13

    The performance and design requirements for the Unified Heliostat Array are established. The Unified Heliostat Array is an array of heliostats on a common terraced structure. Requirements are given for designing and evaluating the individual heliostats. Representative site conditions to be encountered and survived by the array are described, including wind loading, precipitation, insolation, and earthquake, and soil properties are described. Heliostat design load calculations and preliminary design point calculations are presented. (LEW)

  16. Everolimus induces Met inactivation by disrupting the FKBP12/Met complex

    PubMed Central

    Raimondo, Lucia; D'Amato, Valentina; Servetto, Alberto; Rosa, Roberta; Marciano, Roberta; Formisano, Luigi; Mauro, Concetta Di; Orsini, Roberta Clara; Cascetta, Priscilla; Ciciola, Paola; De Maio, Ana Paula; Di Renzo, Maria Flavia; Cosconati, Sandro; Bruno, Agostino; Randazzo, Antonio; Napolitano, Filomena; Montuori, Nunzia; Veneziani, Bianca Maria; Placido, Sabino De; Bianco, Roberto

    2016-01-01

    Inhibition of the mechanistic target of rapamycin (mTOR) is a promising treatment strategy for several cancer types. Rapamycin derivatives such as everolimus are allosteric mTOR inhibitors acting through interaction with the intracellular immunophilin FKBP12, a prolyl isomerase with different cellular functions. Although mTOR inhibitors have significantly improved survival of different cancer patients, resistance and lack of predictive factors of response remain unsolved issues. To elucidate the mechanisms of resistance to everolimus, we evaluated Met activation in everolimus-sensitive/resistant human cancer cells, in vitro and in vivo. Biochemical and computational analyses were performed. Everolimus-resistant cells were xenografted into mice (10/group) and studied for their response to everolimus and Met inhibitors. The statistical significance of the in vitro results was evaluated by Student's t test. Everolimus reduced Met phosphorylation in everolimus-sensitive cells. This event was mediated by the formation of a Met-FKBP12 complex, which in turn is disrupted by everolimus. Aberrant Met activation in everolimus-resistant cells and overexpression of wild-type/mutant Met caused everolimus resistance. Pharmacological inhibition and RNA silencing of Met are effective in condition of everolimus resistance (P<0.01). In mice xenografted with everolimus-resistant cells, the combination of everolimus with the Met inhibitor PHA665752 reduced tumor growth and induced a statistically significant survival advantage (combination vs control P=0.0005). FKBP12 binding is required for full Met activation and everolimus can inhibit Met. Persistent Met activation might sustain everolimus resistance. These results identify a novel everolimus mechanism of action and suggest the development of clinical strategies based on Met inhibitors in everolimus-resistant cancers. PMID:27223077

  17. Annual report, Office of the Inspector General

    SciTech Connect

    Mansfield, J.K.

    1980-03-01

    Activities during the period January 1, 1979 through December 31, 1979 are reported. First, an overview of the progress and problems encountered by this office during the last calendar year is given. Next, certain matters of concern relating to the independence of the office and the ability to work effectively are discussed. Then progress being made and problems being met in forward planning are reviewed. The existing office organizational and staffing patterns are described in the subsequent section. Then weaknesses of the existing DOE overall audit system are discussed. Work done by the IG audit, inspection, and investigative staffs during 1979 is reviewed. Summaries of significant IG findings and recommendations, and of departmental responses thereto, are included. Finally, follow-through activities and certain developments during 1979 that were of importance to the office are described. (RWR)

  18. Complex Spinors and Unified Theories

    NASA Astrophysics Data System (ADS)

    Gell-Mann, Murray; Ramond, Pierre; Slansky, Richard

    We were told by Frank Yang in his welcoming speech that supergravity is a phenomenon of theoretical physics. Why, at this time, is it not more than that? Self-coupled extended supergravity, especially for N = 8, seems very close to the overall unified theory for which all of us have yearned since the time of Einstein. There are no quanta of spin >2 there is just one graviton of spin 2; there are N gravitini of spin 3/2, just right for eating the N Goldstone fermions of spin 1/2 that are needed if N-fold supersymmetry is to be violated spontaneously; there are N(N-1)/2 spin 1 bosons, perfectly suited to be the gauge bosons for SON in the theory with self-coupling. There are N(N - 1)(N - 2)/6 spin 1/2 Majorana particles, and with the simplest assignments of charge and colour they include isotopic doublets of quarks and leptons. The theory is highly non-singular in perturbation theory, and the threatened divergence at the level of three loops has not even been demonstrated. The apparently arbitrary cancellation of huge contributions of opposite sign to the cosmological constant (from self-coupling on the one hand and from spontaneous violation of supersymmetry on the other) has been phrased in such an elegant way that it may be acceptable. (Of course, if we follow Hawking at al., we may not even need to cancel out the cosmological constant!)…

  19. Airbag and ASI/MET instrument in 360-degree panorama

    NASA Technical Reports Server (NTRS)

    1997-01-01

    This view from the lander was imaged by the Imager for Mars Pathfinder (IMP) as part of a 360-degree color panorama, taken over sols 8, 9 and 10. A deflated airbag is at the bottom of the image. At the extreme right, the Atmospheric Structure Instrument and Meteorology package (ASI/MET)mast, with its three windsocks, is visible.are at the bottom right of the image.

    Mars Pathfinder is the second in NASA's Discovery program of low-cost spacecraft with highly focused science goals. The Jet Propulsion Laboratory, Pasadena, CA, developed and manages the Mars Pathfinder mission for NASA's Office of Space Science, Washington, D.C. JPL is an operating division of the California Institute of Technology (Caltech). The Imager for Mars Pathfinder (IMP) was developed by the University of Arizona Lunar and Planetary Laboratory under contract to JPL. Peter Smith is the Principal Investigator.

  20. Fusion of Imperfect Information in the Unified Framework of Random Sets Theory: Application to Target Identification

    DTIC Science & Technology

    2007-11-01

    Informatique WGZ Anne-Laure Jousselme Éloi Bossé DRDC Valcartier Defence R&D Canada – Valcartier Technical Report DRDC Valcartier TR 2003-319 November 2007...Fusion of imperfect information in the unified framework of random sets theory Application to target identification Mihai Cristian Florea Informatique ...Cell CFB Esquimalt P.O. Box 17000 Stn Forces Victoria, British Columbia, V9A 7N2 Attn: Commanding Officer 1 M. C. Florea (author) Informatique WGZ inc

  1. Methionine synthesis in Escherichia coli: effect of the MetR protein on metE and metH expression.

    PubMed

    Cai, X Y; Maxon, M E; Redfield, B; Glass, R; Brot, N; Weissbach, H

    1989-06-01

    Studies by Urbanowski et al. [Urbanowski, M. L., Stauffer, L. T., Plamann, L. S. & Stauffer, G. V. (1987) J. Bacteriol. 169, 1391-1397] have identified a regulatory locus, called metR, required for the expression of the metE and metH genes. We recently purified the MetR protein from Escherichia coli and showed that it could stimulate the in vitro expression of the metE gene and autoregulate its own synthesis. In the present study, the purified MetR protein has been shown to stimulate the in vitro expression of the metH gene. Also, the in vitro synthesized MetE, MetH, and MetR proteins were shown to be biologically active. The transcription start sites for the metE and metR genes have been determined, and DNA footprinting experiments have identified regions in the metE-metR intergenic sequence that are protected by either the MetR or MetJ proteins.

  2. 24 CFR 578.11 - Unified Funding Agency.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 3 2014-04-01 2013-04-01 true Unified Funding Agency. 578.11... of Care § 578.11 Unified Funding Agency. (a) Becoming a Unified Funding Agency. To become designated as the Unified Funding Agency (UFA) for a Continuum, a collaborative applicant must be selected by...

  3. Prototype of the Modular Equipment Transporter (MET)

    NASA Image and Video Library

    1970-02-13

    S70-29505 (13-18 Feb. 1970) --- A prototype of the modular equipment transporter (MET), nicknamed the "Rickshaw" after its shape and method of propulsion. This equipment was used by the Apollo 14 astronauts during their geological and lunar surface simulation training in the Pinacate volcanic area of northwestern Sonora, Mexico. The Apollo 14 crew will be the first one to use the MET. It will be a portable workbench with a place for the lunar hand tools and their carrier, three cameras, two sample container bags, a special environmental sample container, spare film magazines, and a lunar surface Penetrometer.

  4. Association between sleep duration and sleep quality, and metabolic syndrome in Taiwanese police officers.

    PubMed

    Chang, Jen-Hung; Huang, Pai-Tsang; Lin, Yen-Kuang; Lin, Ching-En; Lin, Chien-Min; Shieh, Ying-Hua; Lin, Ying-Chin

    2015-01-01

    This study's objective was to examine association between sleep duration and sleep quality, and metabolic syndrome (MetS) and its components in Taiwanese male police officers. Male police officers who underwent annual health examinations were invited to join the study and eventually a total of 796 subjects was included in it. The study subjects were divided into 5 groups according to the length (duration) of sleep: < 5, 5-5.9, 6-6.9, 7-7.9 and ≥ 8 h per day, and the global Pittsburgh Sleep Quality Index was used to categorize their sleep quality as good or poor. To analyze the association between sleep problems and MetS, adjusted odds ratio and respective 95% confidence intervals (CI) were computed. The prevalence of MetS in Taiwanese male police officers was 24.5%. Abdominal obesity had the highest proportion (36.2%) among 5 components of MetS. More than 1/2 of the police officers (52.3%) had poor sleep quality. Police officers with higher scores of sleep disturbances had a higher prevalence of MetS (p = 0.029) and abdominal obesity (p = 0.009). After adjusting for age, low-density lipoprotein cholesterol, smoking status, alcohol drinking habit, physical habitual exercise, snoring and type of shift work, the police officers who slept less than 5 h were 88% more likely to suffer from abdominal obesity than those who slept 7-7.9 h (95% CI: 1.01-3.5). Sleep quality was not associated with MetS and its components. The police officers who slept less than 5 h were more likely to experience abdominal obesity in Taiwan, and those with higher scores of sleep disturbances had a higher prevalence of MetS and abdominal obesity. It is recommended that police officers with short sleep duration or sleep disturbances be screened for MetS and waist circumference in order to prevent cardiovascular diseases. This work is available in Open Access model and licensed under a CC BY-NC 3.0 PL license.

  5. Functional AdoMet Isosteres Resistant to Classical AdoMet Degradation Pathways.

    PubMed

    Huber, Tyler D; Wang, Fengbin; Singh, Shanteri; Johnson, Brooke R; Zhang, Jianjun; Sunkara, Manjula; Van Lanen, Steven G; Morris, Andrew J; Phillips, George N; Thorson, Jon S

    2016-09-16

    S-adenosyl-l-methionine (AdoMet) is an essential enzyme cosubstrate in fundamental biology with an expanding range of biocatalytic and therapeutic applications. We report the design, synthesis, and evaluation of stable, functional AdoMet isosteres that are resistant to the primary contributors to AdoMet degradation (depurination, intramolecular cyclization, and sulfonium epimerization). Corresponding biochemical and structural studies demonstrate the AdoMet surrogates to serve as competent enzyme cosubstrates and to bind a prototypical class I model methyltransferase (DnrK) in a manner nearly identical to AdoMet. Given this conservation in function and molecular recognition, the isosteres presented are anticipated to serve as useful surrogates in other AdoMet-dependent processes and may also be resistant to, and/or potentially even inhibit, other therapeutically relevant AdoMet-dependent metabolic transformations (such as the validated drug target AdoMet decarboxylase). This work also highlights the ability of the prototypical class I model methyltransferase DnrK to accept non-native surrogate acceptors as an enabling feature of a new high-throughput methyltransferase assay.

  6. MET Senior Projects at an Urban University.

    ERIC Educational Resources Information Center

    Neff, Gregory; And Others

    A report describes the Purdue University Calumet Mechanical Engineering Technology (MET) program, especially the approaches used to enhance industrial involvement and take advantage of the urban setting to find real-life senior project problems. The outreach program, used by faculty to find student senior project material, is described along with…

  7. An Innovative Course Featuring Action Research Integrated with Unifying Science Themes

    NASA Astrophysics Data System (ADS)

    Otto, Charlotte A.; Luera, Gail R.; Everett, Susan A.

    2009-12-01

    In this article, we describe an innovative capstone course for preservice K-8 teachers integrating action research and a unifying theme in science (AAAS in Science for all Americans. Oxford University Press, New York, 1989; NRC in National science education standards. National Academy Press, Washington, DC, 1996). The goals of the capstone course are to increase student knowledge of the unifying theme, improve written communication skills, and introduce students to educational research. We provide evidence that each of these goals is met. Student growth in theme knowledge is demonstrated through concept maps, questionnaires, and previously reported assessments. Improved writing ability is demonstrated using the spelling and grammar checking feature of Microsoft Word. The analysis of action research reports demonstrates that students are able to connect their action research project results to previous research.

  8. Rebound Effects Caused by Withdrawal of MET Kinase Inhibitor Are Quenched by a MET Therapeutic Antibody.

    PubMed

    Pupo, Emanuela; Ducano, Nadia; Lupo, Barbara; Vigna, Elisa; Avanzato, Daniele; Perera, Timothy; Trusolino, Livio; Lanzetti, Letizia; Comoglio, Paolo M

    2016-09-01

    MET oncogene amplification is emerging as a major mechanism of acquired resistance to EGFR-directed therapy in lung and colorectal cancers. Furthermore, MET amplification predicts responsiveness to MET inhibitors currently in clinical trials. Among the anti-MET drugs available, ATP-competitive small-molecule kinase inhibitors abrogate receptor autophosphorylation and downstream activation of ERK1/2 and AKT, resulting in cell-cycle arrest. However, this antiproliferative effect allows persistence of a pool of cancer cells that are quiescent but alive. Once the inhibition is removed, rebound activation of MET-driven cell proliferative pathways and tumor growth may occur, an adverse event observed frequently in clinical settings after drug discontinuation. Here we show that inhibitor withdrawal prompts receptor phosphorylation to levels higher than those displayed at steady-state and generates a rebound effect pushing quiescent cancer cells back into the cell cycle, both in vitro and in experimental tumor models in vivo Mechanistically, we found that inhibitor treatment blocks MET endocytosis, causing a local increase in the number of receptors at the plasma membrane. Upon inhibitor washout, the receptor is readily rephosphorylated. The initial phosphorylation is not only increased but also prolonged in duration due to downmodulation of a phosphatase-mediated MET-negative feedback loop, which accompanies receptor internalization. Notably, treatment with a MET therapeutic antibody that induces proteolytic cleavage of the receptor at the cell surface substantially prevents this rebound effect, providing a rationale to combine or alternate these mechanistically different types of MET-targeted therapy. Cancer Res; 76(17); 5019-29. ©2016 AACR.

  9. Unified Green's Function Retrieval by Cross Correlation

    SciTech Connect

    Wapenaar, Kees; Slob, Evert; Snieder, Roel

    2006-12-08

    It has been shown by many authors that the cross correlation of two recordings of a diffuse wave field at different receivers yields the Green's function between these receivers. Recently the theory has been extended for situations where time-reversal invariance does not hold (e.g., in attenuating media) and where source-receiver reciprocity breaks down (in moving fluids). Here we present a unified theory for Green's function retrieval that captures all these situations and, because of the unified form, readily extends to more complex situations, such as electrokinetic Green's function retrieval in poroelastic or piezoelectric media. The unified theory has a wide range of applications in ''remote sensing without a source.''.

  10. Unified theory in the worldline approach

    NASA Astrophysics Data System (ADS)

    Edwards, James P.

    2015-11-01

    We explore unified field theories based on the gauge groups SU (5) and SO (10) using the worldline approach for chiral fermions with a Wilson loop coupling to a background gauge field. Representing path ordering and chiral projection operators with functional integrals has previously reproduced the sum over the chiralities and representations of standard model particles in a compact way. This paper shows that for SU (5) the 5 bar and 10 representations - into which the Georgi-Glashow model places the left-handed fermionic content of the standard model - appear naturally and with the familiar chirality. We carry out the same analysis for flipped SU (5) and uncover a link to SO (10) unified theory. We pursue this by exploring the SO (10) theory in the same framework, the less established unified theory based on SU (6) and briefly consider the Pati-Salam model using SU (4) × SU (2) × SU (2).

  11. A Unified Fault-Tolerance Protocol

    NASA Technical Reports Server (NTRS)

    Miner, Paul; Gedser, Alfons; Pike, Lee; Maddalon, Jeffrey

    2004-01-01

    Davies and Wakerly show that Byzantine fault tolerance can be achieved by a cascade of broadcasts and middle value select functions. We present an extension of the Davies and Wakerly protocol, the unified protocol, and its proof of correctness. We prove that it satisfies validity and agreement properties for communication of exact values. We then introduce bounded communication error into the model. Inexact communication is inherent for clock synchronization protocols. We prove that validity and agreement properties hold for inexact communication, and that exact communication is a special case. As a running example, we illustrate the unified protocol using the SPIDER family of fault-tolerant architectures. In particular we demonstrate that the SPIDER interactive consistency, distributed diagnosis, and clock synchronization protocols are instances of the unified protocol.

  12. Factors Associated With Met Expectations in Patients With Hand and Upper Extremity Disorders: A Pilot Study.

    PubMed

    Briet, Jan Paul; Hageman, Michiel G J S; Overbeek, Celeste L; Mudgal, Chaitanya; Ring, David C; Vranceanu, Ana-Maria

    2016-01-01

    The degree to which patients' expectations are met during an office visit consistently correlates with patients' satisfaction, whereas the relationship between previsit expectations and satisfaction varies. The aim of this pilot study was to preliminarily assess the relationship of psychosocial factors, pain intensity, and magnitude of disability to previsit expectations, met expectations, and satisfaction with medical care in patients with hand and upper extremity conditions in a surgical outpatient clinic. A cohort of 85 outpatients with upper extremity illnesses indicated their previsit expectations (Patients Intention Questionnaire), degree to which these expectations were met (Expectations Met Questionnaire), level of depressive symptoms (Patient Health Questionnaire-2), confidence about the ability to achieve one's goals in spite of pain (Pain Self-Efficacy Questionnaire), pain intensity (Numerical Rating Scale for pain), disability (Disabilities of the Arm Shoulder and Hand, short version; QuickDASH), and satisfaction with the medical visit (Medical Interview Satisfaction Scale). Higher previsit expectations were associated with more depressive symptoms, lower pain self-efficacy, higher pain intensity, and fewer years of education. Patients in the low and moderate met expectations categories had significantly more symptoms of depression, fewer years of education, and more pain compared to those in the high-met expectations category. Fewer years of education and higher pain intensity predicted higher previsit expectations and explained 19% of variance. Psychosocial factors affect both previsit expectations and met expectations during an outpatient visit to a hand surgeon. Met expectations, but not previsit expectations, affect satisfaction. Prognostic, level II. Copyright © 2016 The Academy of Psychosomatic Medicine. Published by Elsevier Inc. All rights reserved.

  13. Occupation and metabolic syndrome: is there correlation? A cross sectional study in different work activity occupations of German firefighters and office workers.

    PubMed

    Strauß, Markus; Foshag, Peter; Przybylek, Bianca; Horlitz, Marc; Lucia, Alejandro; Sanchis-Gomar, Fabian; Leischik, Roman

    2016-01-01

    The treatment and prevention of the metabolic syndrome (MetS) is currently one of the major challenges in medicine. The impact of working conditions on metabolic risk has not been adequately studied. Our objective was to compare the prevalence of MetS and metabolic risk in two extremely different occupational groups: firefighters and office workers. A total of 143 male subjects (97 firefighters and 46 office workers) from Germany participated in the study. Anthropometric characteristics, metabolic risk parameters as well as laboratory parameters were collected. MetS was diagnosed according to criteria of the International Diabetes Federation. Sedentary occupation showed a significant tendency towards obesity. Abdominal waist circumference was significantly greater in office workers than in firefighters [5.08 CI (1.44-8.71), p = 0.007]. Concerning metabolic risk factors, abnormal HDL, triglycerides, BMI, blood pressure and waist circumference values were more frequently found in office workers than in firefighters. The MetS was detected in almost 33 % of office workers as compared with only 14 % in firefighters (p = 0.015). Regarding MetS in an international comparison, the prevalence of MetS in German office workers was high and in firefighters it was extremely low. Sedentary occupation as an office worker is associated with a high risk of MetS. Both groups need to be made aware of the metabolic risks, and health promoting concepts such as corporate sports activities or education in healthy nutrition need to be implemented to counteract the development of the MetS and cardiovascular risk factors.

  14. [Aerobic fitness in police officers].

    PubMed

    Capodaglio, E M; Imbriani, M; Criffò, A; Tronconi, E

    1996-01-01

    According to act n. 626, individual assessment of fitness and absence of contraindications for carrying on a job is fundamental. We considered a group of 44 Urban Police officers (36 males, 8 females), age 39.7 +/- 9.1, whose principal job requirement is a good energetic and motor availability, for a fitness evaluation through a submaximal treadmill test, with subsequent steps of 6 minutes. During the test, physiological variables (VO2, VE, QR through a metabograph, Hr trough an Ec-monitor and Pa through a manual sphygmomanometer) and subjective evaluations of fatigue and dyspnea were monitored. Studying the individual variables trend it was possible to identify the critical metabolic level that was easily tolerated by each individual. This level, an average of 6.8 MET corresponding to a heavy activity, is an endurance predictor and can be utilized in subsequent controls.

  15. Technical writing practically unified through industry

    NASA Technical Reports Server (NTRS)

    Houston, L. S.

    1981-01-01

    General background details in the development of a university level technical writing program, based upon the writing tasks of the student's occupations, are summarized. Objectives and methods for unifying the courses of study with the needs of industry are discussed. Four academic course divisions, Industries Technologies, in which preparation and training are offered are: Animal, Horticulture, Agriculture, and Agricultural Business. Occupational competence is cited as the main goal for these programs in which technical writing is to be practically unified through industry. Course descriptions are also provided.

  16. Angular MET sensor for precise azimuth determination

    NASA Astrophysics Data System (ADS)

    Zaitsev, Dmitry; Antonov, Alexander; Krishtop, Vladimir

    2016-12-01

    This paper describes using a MET-based low-noise angular motion sensor to precisely determine azimuth direction in a dynamic-scheme method of measuring Earth's rotation velocity vector. The scheme includes installing a sensor on a rotating platform so that it could scan a space and seek for the position of highest Earth's rotation vector projection on its axis. This method is very efficient provided a low-noise sensor is used. We take a low-cost angular sensor based on MET (molecular electronic transduction) technology. Sensors of this kind were originally developed for the seismic activity monitoring and are well-known for very good noise performance and high sensitivity. This approach, combined with use of special signal processing algorithms, allowed for reaching the accuracy of 0.07° for a measurement time of 200 seconds.

  17. nMET, A New Target in Recurrent Cancer.

    PubMed

    Xie, Yingqiu; Istayeva, Sholpan; Chen, Zhanlin; Tokay, Tursonjan; Zhumadilov, Zhaxybay; Wu, Denglong; Hortelano, Gonzalo; Zhang, Jinfu

    2016-01-01

    Membranous Met is classically identified with its role in cancer metastases, while nuclear Met is associated with a more invasive, aggressive and proliferative form of cancer. Full-length Met or N-terminal transmembrane domain cleaved Met can translocate into nucleus in a cell growth and pH dependent but both ligand-dependent (full length Met) and -independent (cleaved Met) manner. nMET may play greater essential roles in cancer recurrence than membranous Met. For example, in prostate cancer, it has been found that androgen receptor (AR) may inhibit the expression of membranous Met so anti-androgen based prostate cancer therapy may promote the expression of nuclear Met (nMET). We recently found a novel nMET/SOX9/ β-Catenin/AR pathway in relapsed prostate cancer which may contribute to the formation of the feedback loop of AR reactivation via MET/nMET. Emerging evidence suggests the possibility of nMET as a prognostic marker in relapsed cancer. This review summarizes recent findings about nMET and its unique role in recurrent cancer.

  18. Could the organ shortage ever be met?

    PubMed

    Levitt, Mairi

    2015-01-01

    The organ shortage is commonly presented as having a clear solution, increase the number of organs donated and the problem will be solved. In the light of the Northern Ireland Assembly's consultation on moving to an opt-out organ donor register this article focuses on the social factors and complexities which impact strongly on both the supply of, and demand for, transplantable organs. Judging by the experience of other countries presumed consent systems may or may not increase donations but have not met demand. Donation rates have risen considerably in all parts of the UK recently but there is also an increasing demand for organs. Looking at international donation rates and attitudes, future demand for organs and education on donation, the question is whether the organ shortage could ever be met. The increase in longevity, in rates of diabetes and obesity and in alcohol related liver disease all contribute both to increased demand for transplants, and re-transplants, and a reduction in the number of usable organs. It is unlikely that demand could ever be met, since, if supply was unlimited, the focus would move to financial resources and competing demands on the health care budget in a publicly funded health system. These factors point to the need to focus on ways of reducing, or at least stabilizing, demand where lifestyle factors contribute to the underlying disease.

  19. Smart Polymeric Nanocarriers of Met-enkephalin.

    PubMed

    Szweda, Roza; Trzebicka, Barbara; Dworak, Andrzej; Otulakowski, Lukasz; Kosowski, Dominik; Hertlein, Justyna; Haladjova, Emi; Rangelov, Stanislav; Szweda, Dawid

    2016-08-08

    This study describes a novel approach to polymeric nanocarriers of the therapeutic peptide met-enkephalin based on the aggregation of thermoresponsive polymers. Thermoresponsive bioconjugate poly((di(ethylene glycol) monomethyl ether methacrylate)-ran-(oligo(ethylene glycol) monomethyl ether methacrylate) is synthesized by AGET ATRP using modified met-enkephalin as a macroinitiator. The abrupt heating of bioconjugate water solution leads to the self-assembly of bioconjugate chains and the formation of mesoglobules of controlled sizes. Mesoglobules formed by bioconjugates are stabilized by coating with cross-linked two-layer shell via nucleated radical polymerization of N-isopropylacrylamide using a degradable cross-linker. The targeting peptide RGD, containing the fluorescence marker carboxyfluorescein, is linked to a nanocarrier during the formation of the outer shell layer. In the presence of glutathione, the whole shell is completely degradable and the met-enkephalin conjugate is released. It is anticipated that precisely engineered nanoparticles protecting their cargo will emerge as the next-generation platform for cancer therapy and many other biomedical applications.

  20. A Performance Comparison of Coupled and Uncoupled Versions of the Met Office Seasonal Prediction GCM

    NASA Astrophysics Data System (ADS)

    Graham, R. J.; Gordon, M.; McLean, P. J.; Ineson, S.; Huddleston, M. R.; Davey, M. K.; Brookshaw, A.; Barnes, R. T.

    2005-05-01

    The launch of COSMIC/Formosat-3 constellation represents a tremendous step forward in the remote sensing of the atmosphere with the GPS radio occultation technique. Not only does it dramatically increase the spatiotemporal coverage over the existing pseudo-constellation of CHAMP, SAC-C, and GRACE, but it is also designed to acquire the occulting GPS signal through the open-loop (OL) tracking mode from the very start. Previous studies have shown that over moist regions, the presence of fine vertical-scale water vapor structures could lead to strong signal dynamics and periods of low signal-to-noise ratio. Data acquired using the traditional closed-loop (CL) tracking mode are therefore prone to introduce errors in the lower troposphere. This has a profound consequence on the water vapor retrievals, especially in the tropics. In this study, we will present results from the analysis of recent OL data from COSMIC and SAC-C. We will discuss the improvement of water vapor retrievals from OL data over CL data from CHAMP and GRACE. An assessment of accuracy in the lower troposphere and the planetary boundary layer will be given, taking into account the possible dry bias due to ducting.

  1. Truncated RAF kinases drive resistance to MET inhibition in MET-addicted cancer cells.

    PubMed

    Petti, Consalvo; Picco, Gabriele; Martelli, Maria Luisa; Trisolini, Elena; Bucci, Enrico; Perera, Timothy; Isella, Claudio; Medico, Enzo

    2015-01-01

    Constitutively active receptor tyrosine kinases (RTKs) are known oncogenic drivers and provide valuable therapeutic targets in many cancer types. However, clinical efficacy of RTK inhibitors is limited by intrinsic and acquired resistance. To identify genes conferring resistance to inhibition of the MET RTK, we conducted a forward genetics screen in the GTL-16 gastric cancer cell line, carrying MET amplification and exquisitely sensitive to MET inhibition. Cells were transduced with three different retroviral cDNA expression libraries and selected for growth in the presence of the MET inhibitor PHA-665752. Selected cells displayed robust and reproducible enrichment of library-derived cDNAs encoding truncated forms of RAF1 and BRAF proteins, whose silencing reversed the resistant phenotype. Transduction of naïve GTL-16 cells with truncated, but not full length, RAF1 and BRAF conferred in vitro and in vivo resistance to MET inhibitors, which could be reversed by MEK inhibition. Induction of resistance by truncated RAFs was confirmed in other MET-addicted cell lines, and further extended to EGFR-addicted cells. These data show that truncated RAF1 and BRAF proteins, recently described as products of genomic rearrangements in gastric cancer and other malignancies, have the ability to render neoplastic cells resistant to RTK-targeted therapy.

  2. Geographic Information Office

    USGS Publications Warehouse

    ,

    2004-01-01

    The Geographic Information Office (GIO) is the principal information office for U.S. Geological Survey (USGS), focused on: Information Policy and Services, Information Technology, Science Information, Information Security, and the Federal Geographic Data Committee/Geospatial One Stop.

  3. Office of Child Care

    MedlinePlus

    ... examples related to the health and safety training provisions of the final regulations published by the Office ... specific information and examples related to the subsidy provisions of the final regulations published by the Office ...

  4. FIFRA Project Officers Manual

    EPA Pesticide Factsheets

    The FIFRA Project Officers Manual provides guidance to new as well as experienced project officers in the management of grants and cooperative agreements under the Federal Insecticide, Fungicide and Rodenticide Act.

  5. Interactive Office user's manual

    NASA Technical Reports Server (NTRS)

    Montgomery, Edward E.; Lowers, Benjamin; Nabors, Terri L.

    1990-01-01

    Given here is a user's manual for Interactive Office (IO), an executive office tool for organization and planning, written specifically for Macintosh. IO is a paperless management tool to automate a related group of individuals into one productive system.

  6. LMAL Accounting Office 1936

    NASA Technical Reports Server (NTRS)

    1936-01-01

    Accounting Office: The Langley Memorial Aeronautical Laboratory's accounting office, 1936, with photographs of the Wright brothers on the wall. Although the Lab was named after Samuel P. Langley, most of the NACA staff held the Wrights as their heroes.

  7. Office of Child Care

    MedlinePlus

    ... Early Head Start-Child Care Partnerships. Review the profiles. > What is the Office of Child Care (OCC)? The Office of Child Care supports low-income working families through child care financial assistance and ...

  8. Pediatric office emergencies.

    PubMed

    Fuchs, Susan

    2013-10-01

    Pediatricians regularly see emergencies in the office, or children that require transfer to an emergency department, or hospitalization. An office self-assessment is the first step in determining how to prepare for an emergency. The use of mock codes and skill drills make office personnel feel less anxious about medical emergencies. Emergency information forms provide valuable, quick information about complex patients for emergency medical services and other physicians caring for patients. Furthermore, disaster planning should be part of an office preparedness plan.

  9. Unified Technical Concepts. Physics for Technicians.

    ERIC Educational Resources Information Center

    Center for Occupational Research and Development, Inc., Waco, TX.

    Unified Technical Concepts (UTC) is a modular system for teaching applied physics in two-year postsecondary programs. This UTC classroom textbook, consisting of 14 chapters, deals with physics for technicians. Addressed in the individual chapters of the guide are the following topics: force, work, rate, momentum, resistance, power, potential and…

  10. Unified Technical Concepts. Application Modules Volume II.

    ERIC Educational Resources Information Center

    Center for Occupational Research and Development, Inc., Waco, TX.

    Unified Technical Concepts (UTC) is a modular system for teaching applied physics in two-year postsecondary technician programs. This UTC laboratory textbook, the second of two volumes, consists of 45 learning modules dealing with basic concepts of physics. Addressed in the individual chapters of the guide are the following topics: force…

  11. Unified Database Development Program. Final Report.

    ERIC Educational Resources Information Center

    Thomas, Everett L., Jr.; Deem, Robert N.

    The objective of the unified database (UDB) program was to develop an automated information system that would be useful in the design, development, testing, and support of new Air Force aircraft weapon systems. Primary emphasis was on the development of: (1) a historical logistics data repository system to provide convenient and timely access to…

  12. A Unified Introduction to Ordinary Differential Equations

    ERIC Educational Resources Information Center

    Lutzer, Carl V.

    2006-01-01

    This article describes how a presentation from the point of view of differential operators can be used to (partially) unify the myriad techniques in an introductory course in ordinary differential equations by providing students with a powerful, flexible paradigm that extends into (or from) linear algebra. (Contains 1 footnote.)

  13. Unified classical path theories of pressure broadening.

    NASA Technical Reports Server (NTRS)

    Bottcher, C.

    1971-01-01

    Derivation of a unified classical path theory of pressure broadening, using only elementary concepts. It is shown that the theory of Smith, Cooper and Vidal (1969) is only correct at all frequencies to first order in the number density of perturbers.

  14. Molecular selection in a unified evolutionary sequence

    NASA Technical Reports Server (NTRS)

    Fox, S. W.

    1986-01-01

    With guidance from experiments and observations that indicate internally limited phenomena, an outline of unified evolutionary sequence is inferred. Such unification is not visible for a context of random matrix and random mutation. The sequence proceeds from Big Bang through prebiotic matter, protocells, through the evolving cell via molecular and natural selection, to mind, behavior, and society.

  15. Toward a Unified Theory of Reading

    ERIC Educational Resources Information Center

    Sadoski, Mark; Paivio, Allan

    2007-01-01

    Despite nearly 40 years of scientific theorizing about reading, the field remains fragmented with little progress toward unification. In this article, we (a) emphasize the privileged position of unified theories in all science, (b) compare the growth of theory in cognitive science and reading, (c) identify the phenomenal domain of a unified…

  16. Unified Technical Concepts. Application Modules Volume II.

    ERIC Educational Resources Information Center

    Center for Occupational Research and Development, Inc., Waco, TX.

    Unified Technical Concepts (UTC) is a modular system for teaching applied physics in two-year postsecondary technician programs. This UTC laboratory textbook, the second of two volumes, consists of 45 learning modules dealing with basic concepts of physics. Addressed in the individual chapters of the guide are the following topics: force…

  17. Unified Technical Concepts. Application Modules Volume I.

    ERIC Educational Resources Information Center

    Center for Occupational Research and Development, Inc., Waco, TX.

    Unified Technical Concepts (UTC) is a modular system for teaching applied physics in two-year postsecondary technician programs. This UTC laboratory textbook, the first of two volumes, consists of 56 learning modules dealing with basic concepts of physics. Addressed in the individual chapters of the guide are the following topics: force, work,…

  18. A Unified Stability Property in Spin Glasses

    NASA Astrophysics Data System (ADS)

    Panchenko, Dmitry

    2012-08-01

    Gibbs' measures in the Sherrington-Kirkpatrick type models satisfy two asymptotic stability properties, the Aizenman-Contucci stochastic stability and the Ghirlanda-Guerra identities, which play a fundamental role in our current understanding of these models. In this paper we show that one can combine these two properties very naturally into one unified stability property.

  19. A Unifying Curriculum for Museum-Schools

    ERIC Educational Resources Information Center

    Povis, Kaleen E.

    2011-01-01

    There are over two dozen schools in the United States with the word "museum" in their names. However, the philosophy and pedagogy that tie these schools together is unclear. A consistent definition, criteria for classification, and a unifying curriculum to guide museum- schools is lacking. Yet, museum-schools continue to open across the country.…

  20. Unified Technical Concepts. Math for Technicians.

    ERIC Educational Resources Information Center

    Center for Occupational Research and Development, Inc., Waco, TX.

    Unified Technical Concepts (UTC) is a modular system for teaching applied physics in two-year postsecondary technician programs. This UTC classroom textbook, consisting of 10 chapters, deals with mathematical concepts as they apply to the study of physics. Addressed in the individual chapters of the text are the following topics: angles and…

  1. Toward a Unified Theory of Reading

    ERIC Educational Resources Information Center

    Sadoski, Mark; Paivio, Allan

    2007-01-01

    Despite nearly 40 years of scientific theorizing about reading, the field remains fragmented with little progress toward unification. In this article, we (a) emphasize the privileged position of unified theories in all science, (b) compare the growth of theory in cognitive science and reading, (c) identify the phenomenal domain of a unified…

  2. Discovery of the Grand Unified Theory

    NASA Astrophysics Data System (ADS)

    Nair, Radhakrishnan

    2010-11-01

    I have discovered the Grand Unified Theory which unites quantum with classical mechanics. This discovery is based on a geocentric universe, the myth of empty space, four states of matter in three dimensional space and space-time exponentiation, instead of space-time curvature.

  3. Unified approach for singularly perturbed control systems

    NASA Astrophysics Data System (ADS)

    Singh, Hardev

    2001-07-01

    The theory of singular perturbation has been a highly recognized and rapidly developing area of control systems in the last thirty years. Results now exists for both the continuous-time and discrete-time systems. However, in the way that these results are normally presented, the solutions to the discrete-time and continuous-time cases evolve from different starting points and seem to bear no relationship to each other. The aim of this dissertation is to develop a unified framework for discrete-time and continuous-time singularly perturbed systems. The discrete-time singularly perturbed control systems results are reorganized so that they are compatible in a way that the continuous-time singularly perturbed control system results are normally presented. This is, in part, achieved by using a newly developed "Unified Approach" to digital system theory, first proposed by Middleton and Goodwin. We first formulate the problem by modeling the singular perturbation parameter from the standpoint of the state space formulation and the second order unified equation. Building upon these results, we further apply this technique to state-feedback, robust state-feedback, Linear Quadratic Regulator (LQR) and Hinfinity optimization control problems. The unified results developed in this Dissertation are valid for both the continuous-time case (sampling interval T = 0) and the discrete-time (sampling interval T > 0).

  4. A Grand Unified Theory of Interdisciplinarity

    ERIC Educational Resources Information Center

    Davis, Lennard J.

    2007-01-01

    Aside from the appeal to administrators as a tool to reduce costs by combining less robust departments with heftier relations, interdisciplinarity is a powerful idea because it implies that different branches of knowledge can benefit from talking to one another: a grand, unified theory of knowledge in which each discipline contributes building…

  5. Unified Technical Concepts. Application Modules Volume I.

    ERIC Educational Resources Information Center

    Center for Occupational Research and Development, Inc., Waco, TX.

    Unified Technical Concepts (UTC) is a modular system for teaching applied physics in two-year postsecondary technician programs. This UTC laboratory textbook, the first of two volumes, consists of 56 learning modules dealing with basic concepts of physics. Addressed in the individual chapters of the guide are the following topics: force, work,…

  6. A Grand Unified Theory of Interdisciplinarity

    ERIC Educational Resources Information Center

    Davis, Lennard J.

    2007-01-01

    Aside from the appeal to administrators as a tool to reduce costs by combining less robust departments with heftier relations, interdisciplinarity is a powerful idea because it implies that different branches of knowledge can benefit from talking to one another: a grand, unified theory of knowledge in which each discipline contributes building…

  7. A unified approach to Fierz identities

    NASA Astrophysics Data System (ADS)

    Babalic, E. M.; Coman, I. A.; Lazaroiu, C. I.

    2013-11-01

    We summarize a unified and computationally efficient treatment of Fierz identities for form-valued pinor bilinears in various dimensions and signatures, using concepts and techniques borrowed from a certain approach to spinors known as "geometric algebra". Our formulation displays the real, complex and quaternionic structures in a conceptually clear manner, which is moreover amenable to implementation in various symbolic computation systems.

  8. Unified Technical Concepts. Physics for Technicians.

    ERIC Educational Resources Information Center

    Center for Occupational Research and Development, Inc., Waco, TX.

    Unified Technical Concepts (UTC) is a modular system for teaching applied physics in two-year postsecondary programs. This UTC classroom textbook, consisting of 14 chapters, deals with physics for technicians. Addressed in the individual chapters of the guide are the following topics: force, work, rate, momentum, resistance, power, potential and…

  9. Unified Modern Mathematics, Course 2, Teachers Commentary.

    ERIC Educational Resources Information Center

    Secondary School Mathematics Curriculum Improvement Study, New York, NY.

    This commentary is designed for use with "Unified Modern Mathematics, Course II," Parts 1 and 2. As in the commentary for "Course I," statements of the specific purposes and goals of each section of every chapter are presented. Also included are suggestions for teaching the concepts presented in each section, time estimates for each section,…

  10. Unified Modern Mathematics, Course 1, Teachers Commentary.

    ERIC Educational Resources Information Center

    Secondary School Mathematics Curriculum Improvement Study, New York, NY.

    This commentary is designed for use with "Unified Modern Mathematics, Course I," Parts 1 and 2. Included in the commentary are statements of the specific purposes and goals of each section of every chapter, suggestions for teaching the concepts presented in each section, time estimates for each section, suggested instructional aids for presenting…

  11. Unified Modern Mathematics, Course 3, Teachers Commentary.

    ERIC Educational Resources Information Center

    Secondary School Mathematics Curriculum Improvement Study, New York, NY.

    This commentary is to be used with "Unified Modern Mathematics, Course III." Statements of specific purposes and goals of each section of every chapter of Course III are included in the "Commentary." Also included are suggestions for teaching concepts presented in each section; time estimates for each section; suggested instructional aids for…

  12. Liaison Officer Toolkit

    DTIC Science & Technology

    2010-01-01

    pharmacists , epidemiologists, safety officers, logisticians, DSCA Handbook Liaison Officer Toolkit 7-26 UNCLASSIFIED High Demand Task...DSCA Handbook Liaison Officer Toolkit GTA 90-01-021 Approved for public release; distribution is unlimited. Report Documentation Page...Planning Chapters Chapter 5 provides DSCA planning factors for response to all hazard events. Chapter 6 is a review of safety and operational/composite

  13. Office Computers: Ergonomic Considerations.

    ERIC Educational Resources Information Center

    Ganus, Susannah

    1984-01-01

    Each new report of the office automation market indicates technology is overrunning the office. The impacts of this technology are described and some ways to manage and physically "soften" the change to a computer-based office environment are suggested. (Author/MLW)

  14. Work Stress and Metabolic Syndrome in Police Officers. A Prospective Study.

    PubMed

    Garbarino, Sergio; Magnavita, Nicola

    2015-01-01

    The aim of this longitudinal study was to evaluate the association between occupational stress and metabolic syndrome (MetS) in a rapid response police unit. Work-related stress was continuously monitored during the 5-year period with both the Demand-Control-Support (DCS) and the Effort-Reward Imbalance (ERI) models. Blood pressure, body mass index (BMI), waist circumference, triglycerides, HDL-cholesterol, and fasting blood glucose were measured at baseline in January 2009, and in January 2014. 234 out of 290 police officers (81%) completed the follow-up. The majority of police officers had high stress levels. At follow-up, police officers in the highest quartile of stress had significantly higher mean levels of triglycerides, and lower levels of HDL-cholesterol than their colleagues in the lowest quartile. Police officers with high stress had an increased adjusted risk of developing MetS (aOR = 2.68; CI95% = 1.08-6.70), and hypertriglyceridemia (aOR = 7.86; CI95 = 1.29-48.04). Demand and Effort were significant predictors of MetS. Our study supports the hypothesis that work-related stress induces MetS, particularly through its effects on blood lipids. Future longitudinal studies with continuous monitoring of stress levels will definitively confirm this hypothesis.

  15. Work Stress and Metabolic Syndrome in Police Officers. A Prospective Study

    PubMed Central

    Garbarino, Sergio; Magnavita, Nicola

    2015-01-01

    Objective The aim of this longitudinal study was to evaluate the association between occupational stress and metabolic syndrome (MetS) in a rapid response police unit. Method Work-related stress was continuously monitored during the 5-year period with both the Demand-Control-Support (DCS) and the Effort-Reward Imbalance (ERI) models. Blood pressure, body mass index (BMI), waist circumference, triglycerides, HDL-cholesterol, and fasting blood glucose were measured at baseline in January 2009, and in January 2014. 234 out of 290 police officers (81%) completed the follow-up. Results The majority of police officers had high stress levels. At follow-up, police officers in the highest quartile of stress had significantly higher mean levels of triglycerides, and lower levels of HDL-cholesterol than their colleagues in the lowest quartile. Police officers with high stress had an increased adjusted risk of developing MetS (aOR = 2.68; CI95% = 1.08–6.70), and hypertriglyceridemia (aOR = 7.86; CI95 = 1.29–48.04). Demand and Effort were significant predictors of MetS. Conclusion Our study supports the hypothesis that work-related stress induces MetS, particularly through its effects on blood lipids. Future longitudinal studies with continuous monitoring of stress levels will definitively confirm this hypothesis. PMID:26641879

  16. Phoenix `07 MET Pressure sensor: Instrument

    NASA Astrophysics Data System (ADS)

    Polkko, J.; Kahanpää, H.; Harri, A.-M.; Schmidt, W.; Genzer, M.; Mäkelä, M.; Savijarvi, H.; Kauhanen, J.

    2008-09-01

    Abstract The Phoenix '07 Lander landed successfully on the Martian northern polar region 25.5.2008. The mission is part of the National Aeronautics and Space Administration's (NASA's) Scout program. The seminal questions for the Phoenix mission are: (1) can the Martian arctic support life, (2) what is the history of water at the landing site, and (3) how is the Martian climate affected by polar dynamics. These translate into practical science goals and tasks of characterizing the surface, analyzing samples of the soil and ice, and to observing and monitoring the atmospheric conditions and phenomena. Meteorology experiment (MET) onboard the Phoenix '07 lander will provide the first surface based observations of atmospheric pressure, temperature and wind in the Martian polar region above the polar circle. The MET instrument also includes a lidar for detecting dust and ice particles in the air column above the lander. Pressure observations are crucial for the success of the MET experiment. The Martian atmosphere goes through a large scale atmospheric pressure cycle due to the annual condensation and sublimation of the atmospheric carbon dioxide. Pressure also exhibits short period variations associated with dust storms, tides and other atmospheric events. A series of pressure measurements can hence tell us about the large scale state and dynamics of the atmosphere. The shorter time scale phenomena are also important in contributing to our understanding of mixing and transport of heat, dust and water vapour. The pressure observations are performed by a FMI (Finnish Meteorological Institute) instrument, based on micro machined Barocap capacitic pressure sensor heads manufactured by Vaisala Inc. Similar instruments have been used in several earlier missions (Mars-96, Mars Polar Lander, Beagle-2 and Huygens), Phoenix being the first successful landing on Mars. A similar instrument is included also in the Mars Science Laboratory '09 rover. Pressure sensor technology

  17. Impressions of psychotherapists' offices.

    PubMed

    Nasar, Jack L; Devlin, Ann Sloan

    2011-07-01

    For counseling settings, research suggests that softness, personalization, and order might affect the experience and the perceived expertness, trustworthiness, and social attractiveness of the therapist. This article discusses exploratory studies on college students' perception of the counseling office environment and whether the likely client experience was associated with the softness/personalization and order of the office. As stimuli, the studies used 30 color photographs of psychotherapists' offices viewed from the client's perspective. After obtaining ratings of the characteristics of each office, we obtained ratings from different groups of students of the quality of care and comfort expected in each office (Study 1) and how qualified, bold, and friendly the therapist in the office would be (Study 2). Additional studies examined the likelihood of choosing a therapist based on the office, and the first thought or feeling that came to mind about the office, the therapist, and the patient experience. There were strong correlations in response between groups (by whether they had experienced therapy; their level in school; their gender; and their major, location, and school size). The quality of care, comfort, therapist boldness, qualifications of the therapist, and the likelihood that one would choose a therapist based on the office improved with increases in the office's softness/personalization and order. Friendliness improved with increases in softness/personalization. The office choices, open-ended responses, and reported reasons for the ratings confirmed the importance of softness (comfort) and order. Research should test longer term exposure and behavior.

  18. ARM mobile facility surface meteorology (MET) handbook.

    SciTech Connect

    Ritsche, M. T.; Environmental Science Division

    2006-04-01

    The Atmospheric Radiation Measurement (ARM) Mobile Facility Surface Meteorology station (MET) uses mainly conventional in situ sensors to obtain 1-min statistics of surface wind speed, wind direction, air temperature, relative humidity (RH), barometric pressure, and rainrate. Additional sensors may be added to or removed from the base set of sensors depending upon the deployment location, climate regime, or programmatic needs. In addition, sensor types may change depending upon the climate regime of the deployment. These changes/additions are noted in Section 3.

  19. Met-enkephalin levels during PTCA-induced myocardial ischemia.

    PubMed

    Parlapiano, C; Borgia, M C; Tonnarini, G; Giancaspro, G; Pizzuto, F; Campana, E; Giovanniello, T; Pantone, P; Vincentelli, G M; Alegiani, F; Negri, M

    2001-07-01

    Met-enkephalin (Met-enk) has been demonstrated to modulate myocardial-ischemia mechanisms via the opioid receptors, but no studies are now available on Met-enk levels in the coronary circulation. In this experience Met-enk levels were evaluated in aortic root and in coronary sinus at baseline (T0), during PTCA induced transient ischemia (T1) and during reperfusion (T2). No significant differences were found at any time. Thus, it appears that there is no Met-enk extraction from the coronary circulation during provoked myocardial ischemia and no Met-enk release from the ischemic heart.

  20. Mars MetNet Precursor Mission Status

    NASA Astrophysics Data System (ADS)

    Harri, Ari-Matti; Aleksashkin, Sergey; Guerrero, Héctor; Schmidt, Walter; Genzer, Maria; Vazquez, Luis; Haukka, Harri

    2013-04-01

    A new kind of planetary exploration mission for Mars is being developed in collaboration between the Finnish Meteorological Institute (FMI), Lavochkin Association (LA), Space Research Institute (IKI) and Institutio Nacional de Tecnica Aerospacial (INTA). The Mars MetNet mission is based on a new semi-hard landing vehicle called MetNet Lander (MNL), using an inflatable entry and descent system instead of rigid heat shields and parachutes as earlier semi-hard landing devices have used. This way the ratio of the payload mass to the overall mass is optimized. The landing impact will burrow the payload container into the Martian soil providing a more favorable thermal environment for the electronics and a suitable orientation of the telescopic boom with external sensors and the radio link antenna. It is planned to deploy several tens of MNLs on the Martian surface operating at least partly at the same time to allow meteorological network science. For the precursor mission (MMPM) intended to verify the landing concept and key technology during a real Mars mission all qualification activities are completed and the payload and system flight model components are being manufactured. The descent processes dynamic properties are monitored by a special 3-axis accelerometer combined with a 3-axis gyrometer. The data will be sent via auxiliary beacon antenna throughout the descent phase starting shortly after separation from the spacecraft. Details of the current MMPM system and payload configuration and their performance parameters will be shown.

  1. 6. Interior, rear offices: operations assistant office looking north toward ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Interior, rear offices: operations assistant office looking north toward security operations officer's office. - Ellsworth Air Force Base, Rushmore Air Force Station, Security Central Control Building, Quesada Drive, Blackhawk, Meade County, SD

  2. Targeting of the MET receptor tyrosine kinase by small molecule inhibitors leads to MET accumulation by impairing the receptor downregulation.

    PubMed

    Leiser, Dominic; Pochon, Benoît; Blank-Liss, Wieslawa; Francica, Paola; Glück, Astrid A; Aebersold, Daniel M; Zimmer, Yitzhak; Medová, Michaela

    2014-03-03

    The MET receptor tyrosine kinase is deregulated primarily via overexpression or point mutations in various human cancers and different strategies for MET inhibition are currently evaluated in clinical trials. We observed by Western blot analysis and by Flow cytometry that MET inhibition by different MET small molecule inhibitors surprisingly increases in a dose-dependent manner total MET levels in treated cells. Mechanistically, this inhibition-related MET accumulation was associated with reduced Tyr1003 phosphorylation and MET physical association with the CBL ubiquitin ligase with concomitant decrease in MET ubiquitination. These data may suggest careful consideration for design of anti-MET clinical protocols. Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

  3. The control region of the metH gene of Salmonella typhimurium LT2: an atypical met promoter.

    PubMed

    Urbanowski, M L; Stauffer, G V

    1988-12-15

    The control region of the Salmonella typhimurium metH gene was sequenced and the transcription start point was determined by S1 nuclease mapping experiments. Activation of the metH gene by the metR gene product was shown to occur at the level of transcription. The translation start site was determined by amino acid sequence analysis of the amino terminus of a chimeric Met-Lac fusion protein encoded by a metH-lacZ gene fusion. Analysis of the nucleotide sequence of the metH promoter region showed that two sequence elements, present in the promoters of all other met biosynthetic genes thus far examined, are not present in the metH promoter region, namely, the repeated MetJ repressor recognition sequence 5'-AGACGTCT-3' and a highly conserved sequence 5'-TGGA----TAAAC-3' of unknown function.

  4. c-Met in chromophobe renal cell carcinoma.

    PubMed

    Erlmeier, Franziska; Ivanyi, Philipp; Hartmann, Arndt; Autenrieth, Michael; Wiedemann, Max; Weichert, Wilko; Steffens, Sandra

    2017-02-01

    c-Met plays a role as a prognostic marker in clear cell renal cell carcinoma. In addition, recently the tyrosine kinase inhibitor cabozantinib targeting c-Met was approved for the treatment of advanced renal cell carcinoma (RCC). In contrast to clear cell RCC, little is known about c-Met expression patterns in rarer RCC subtypes. The aim of this study was to evaluate the prevalence, distribution and prognostic impact of c-Met expression on chromophobe (ch)RCC. Patients who underwent renal surgery due to chRCC were retrospectively evaluated. Tumor specimens were analyzed for c-Met expression by immunohistochemistry. Expression data were associated with clinicopathological parameters including patient survival. Eighty-one chRCC patients were eligible for analysis. Twenty-four (29.6%) patients showed a high c-Met expression (c-Met(high), staining intensity higher than median). Our results showed an association between c-Met(high) expression and the existence of lymph node metastasis (p = 0.007). No further significant clinicopathological associations with c-Met were identified, also regarding c-Met expression and overall survival. In conclusion, to our knowledge this is the first study evaluating the prognostic impact of c-Met in a considerably large cohort of chRCC. High c-Met expression is associated with the occurrence of lymph node metastasis. This indicates that c-Met might be implicated into metastatic progression in chRCC.

  5. Determining unmet, adequately met, and overly met needs for health care and services for persons living with HIV/AIDS in Mississippi.

    PubMed

    Krause, Denise D; May, Warren L; Butler, Kenneth R

    2013-08-01

    A statewide needs assessment of persons living with HIV/AIDS (PLWHA) was conducted to determine what is known about access to care, utilization of services, and perceived barriers to receiving care and services. Our objective was to determine which needs were being met or unmet among PLWHA in Mississippi to provide a better understanding of how effectively to allocate funding to provide for the needs of that group. In this cross-sectional study, a true random sample of PLWHA in Mississippi was interviewed in 2005-2006. Questions were asked to identify opinions about respondents' experiences with 23 health care services and 30 public or private assistance services. The kappa statistic was used to measure agreement between level of services needed and level of services provided. Services with the lowest kappa scores revealed which services were being either mostly unmet, or even overly met. Greatest service needs were HIV viral load test, Pap smear, CD4/T-cell count test, and medication for HIV/AIDS, which were reasonably well met. The most significantly unmet needs were dental care and dental exams, eye care and eye exams, help paying for housing, subsidized housing assistance, mental health therapy or counseling, access to emotional support groups, and job placement or employment. Overly met services included medical care at a physician's office or clinic and free condoms. This study identified needs perceived to be significantly unmet by PLWHA, as well as areas that were perceived to be adequately or overly met. This information may be used to target areas with the greatest impact for improvement and provide insight into how to effectively allocate health care resources and public/private assistance.

  6. Multi-planed unified switching topologies

    DOEpatents

    Chen, Dong; Heidelberger, Philip; Sugawara, Yutaka

    2017-07-04

    An apparatus and method for extending the scalability and improving the partitionability of networks that contain all-to-all links for transporting packet traffic from a source endpoint to a destination endpoint with low per-endpoint (per-server) cost and a small number of hops. An all-to-all wiring in the baseline topology is decomposed into smaller all-to-all components in which each smaller all-to-all connection is replaced with star topology by using global switches. Stacking multiple copies of the star topology baseline network creates a multi-planed switching topology for transporting packet traffic. Point-to-point unified stacking method using global switch wiring methods connects multiple planes of a baseline topology by using the global switches to create a large network size with a low number of hops, i.e., low network latency. Grouped unified stacking method increases the scalability (network size) of a stacked topology.

  7. Embodiment as a unifying perspective for psychology.

    PubMed

    Glenberg, Arthur M

    2010-07-01

    A basic claim of the embodiment framework is that all psychological processes are influenced by body morphology, sensory systems, motor systems, and emotions. As such, the framework holds the promise of providing a unifying perspective for psychological research. This article begins with a sketch of several arguments, from evolution to philosophy, as to why the embodiment framework is a good bet. These arguments are followed by a review of approaches to embodiment, including those from cognitive linguistics, perceptual symbol theory, and action-based theories. Finally, examples are provided for how a unifying perspective might work for cognition (including language and memory), cognitive and social development, social psychology, neuroscience, clinical psychology, and psychology applied to education. Copyright © 2010 John Wiley & Sons, Ltd. For further resources related to this article, please visit the WIREs website. Copyright © 2010 John Wiley & Sons, Ltd.

  8. A proposed unified framework for biological invasions.

    PubMed

    Blackburn, Tim M; Pyšek, Petr; Bacher, Sven; Carlton, James T; Duncan, Richard P; Jarošík, Vojtěch; Wilson, John R U; Richardson, David M

    2011-07-01

    There has been a dramatic growth in research on biological invasions over the past 20 years, but a mature understanding of the field has been hampered because invasion biologists concerned with different taxa and different environments have largely adopted different model frameworks for the invasion process, resulting in a confusing range of concepts, terms and definitions. In this review, we propose a unified framework for biological invasions that reconciles and integrates the key features of the most commonly used invasion frameworks into a single conceptual model that can be applied to all human-mediated invasions. The unified framework combines previous stage-based and barrier models, and provides a terminology and categorisation for populations at different points in the invasion process.

  9. UMLF: a unified medical lexicon for French.

    PubMed

    Zweigenbaum, Pierre; Baud, Robert; Burgun, Anita; Namer, Fiammetta; Jarrousse, Eric; Grabar, Natalia; Ruch, Patrick; Le Duff, Franck; Forget, Jean-François; Douyère, Magaly; Darmoni, Stéfan

    2005-03-01

    Medical Informatics has a constant need for basic medical language processing tasks, e.g. for coding into controlled vocabularies, free text indexing and information retrieval. Most of these tasks involve term matching and rely on lexical resources: lists of words with attached information, including inflected forms and derived words, etc. Such resources are publicly available for the English language with the UMLS Specialist Lexicon, but not in other languages. For the French language, several teams have worked on the subject and built local lexical resources. The goal of the present work is to pool and unify these resources and to add extensively to them by exploiting medical terminologies and corpora, resulting in a unified medical lexicon for French (UMLF). This paper exposes the issues raised by such an objective, describes the methods on which the project relies and illustrates them with experimental results.

  10. Unified Process Planning, the Allison approach

    NASA Astrophysics Data System (ADS)

    Simmons, Clair

    Process Planning, the organization of product/process information for the manufacturing enterprise, represents the lead activity within the manufacturing portion of a business. Process planning encompasses all aspects that contribute to the successful manufacture of a quality product. This paper explains the role of process planning and how a 'Unified Process Plan' (UPP) provides Allison with a more effective and organized method of manufacturing information management. This approach allows for a more effective use of the manufacturing engineering staff. Allison is transitioning to a knowledge base of process information that will be continually improved and accessible to every engineer and operator. Unified Process Planning focuses key pieces of information into one manageable and controlled environment.

  11. Unified Viscoplastic Behavior of Metal Matrix Composites

    NASA Technical Reports Server (NTRS)

    Arnold, S. M.; Robinson, D. N.; Bartolotta, P. A.

    1992-01-01

    The need for unified constitutive models was recognized more than a decade ago in the results of phenomenological tests on monolithic metals that exhibited strong creep-plasticity interaction. Recently, metallic alloys have been combined to form high-temperature ductile/ductile composite materials, raising the natural question of whether these metallic composites exhibit the same phenomenological features as their monolithic constituents. This question is addressed in the context of a limited, yet definite (to illustrate creep/plasticity interaction) set of experimental data on the model metal matrix composite (MMC) system W/Kanthal. Furthermore, it is demonstrated that a unified viscoplastic representation, extended for unidirectional composites and correlated to W/Kanthal, can accurately predict the observed longitudinal composite creep/plasticity interaction response and strain rate dependency. Finally, the predicted influence of fiber orientation on the creep response of W/Kanthal is illustrated.

  12. Shuttle unified navigation filter, revision 1

    NASA Technical Reports Server (NTRS)

    Muller, E. S., Jr.

    1973-01-01

    Equations designed to meet the navigation requirements of the separate shuttle mission phases are presented in a series of reports entitled, Space Shuttle GN and C Equation Document. The development of these equations is based on performance studies carried out for each particular mission phase. Although navigation equations have been documented separately for each mission phase, a single unified navigation filter design is embodied in these separate designs. The purpose of this document is to present the shuttle navigation equations in a form in which they would most likely be coded-as the single unified navigation filter used in each mission phase. This document will then serve as a single general reference for the navigation equations replacing each of the individual mission phase navigation documents (which may still be used as a description of a particular navigation phase).

  13. A survey of unified constitutive theories

    NASA Technical Reports Server (NTRS)

    Chan, K. S.; Lindholm, U. S.; Bodner, S. R.; Walker, K. P.

    1985-01-01

    The state of the art of time temperature dependent elastic viscoplastic constitutive theories which are based on the unified approach werre assessed. This class of constitutive theories is characterized by the use of kinetic equations and internal variables with appropriate evolutionary equations for treating all aspects of inelastic deformation including plasticity, creep, and stress relaxation. More than 10 such unified theories which are shown to satisfy the uniqueness and stability criteria imposed by Drucker's postulate and Ponter's inequalities are identified. The theories are compared for the types of flow law, kinetic equation, evolutionary equation of the internal variables, and treatment of temperature dependence. The similarities and differences of these theories are outlined in terms of mathematical formulations and illustrated by comparisons of theoretical calculations with experimental results which include monotonic stress-strain curves, cyclic hysteresis loops, creep and stress relaxation rates, and thermomechanical loops. Numerical methods used for integrating these stiff time temperature dependent constitutive equations are reviewed.

  14. 20 CFR 422.5 - District offices and branch offices.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false District offices and branch offices. 422.5... and Functions of the Social Security Administration § 422.5 District offices and branch offices. There are over 700 social security district offices and branch offices located in the principal cities...

  15. Unified models of inflation and quintessence

    SciTech Connect

    Gonzalez, Andro; Matos, Tonatiuh; Quiros, Israel

    2005-04-15

    We apply an extended version of the method developed by Chimento and Jakubi [Int. J. Mod. Phys. D 5, 71 (1996)], to derive exact cosmological (flat) Friedmann-Robertson-Walker solutions in RS2 brane models with a perfect fluid of ordinary matter plus a scalar field fluid trapped on the brane. We found new exact solutions, which could serve to unify inflation and quintessence in a common theoretical framework.

  16. Review of Unified and Specified Command Headquarters

    DTIC Science & Technology

    1988-02-01

    REVIEW OF UNIFIED AND SPECIFIED COMMAND HEADQUARTERS February 1988 Report Documentation Page Form ApprovedOMB No. 0704-0188 Public reporting...MONITOR’S REPORT NUMBER(S) 12. DISTRIBUTION/AVAILABILITY STATEMENT Approved for public release; distribution unlimited 13. SUPPLEMENTARY NOTES 14...of the Service Chiefs , who in turn were pre- negot ia t ing decis ions on key issues . During the past 38 years , in an a t tempt to correct

  17. Towards a unified theory of reciprocity.

    PubMed

    Rosas, Alejandro

    2012-02-01

    In a unified theory of human reciprocity, the strong and weak forms are similar because neither is biologically altruistic and both require normative motivation to support cooperation. However, strong reciprocity is necessary to support cooperation in public goods games. It involves inflicting costs on defectors; and though the costs for punishers are recouped, recouping costs requires complex institutions that would not have emerged if weak reciprocity had been enough.

  18. Unifying decoherence and the Heisenberg Principle

    NASA Astrophysics Data System (ADS)

    Janssens, Bas

    2017-03-01

    We exhibit three inequalities involving quantum measurement, all of which are sharp and state independent. The first inequality bounds the performance of joint measurement. The second quantifies the trade-off between the measurement quality and the disturbance caused on the measured system. Finally, the third inequality provides a sharp lower bound on the amount of decoherence in terms of the measurement quality. This gives a unified description of both the Heisenberg uncertainty principle and the collapse of the wave function.

  19. Unifying Theories in Isabelle/HOL

    NASA Astrophysics Data System (ADS)

    Feliachi, Abderrahmane; Gaudel, Marie-Claude; Wolff, Burkhart

    In this paper, we present various extensions of Isabelle/HOL by theories that are essential for several formal methods. First, we explain how we have developed an Isabelle/HOL theory for a part of the Unifying Theories of Programming (UTP). It contains the theories of alphabetized relations and designs. Then we explain how we have encoded first the theory of reactive processes and then the UTP theory for CSP. Our work takes advantage of the rich existing logical core of HOL.

  20. Unified treatment of lifting atmospheric entry

    NASA Technical Reports Server (NTRS)

    Nachtsheim, P. R.; Lehman, L. L.

    1980-01-01

    This paper presents a unified treatment of the effect of lift on peak acceleration during atmospheric entry. Earlier studies were restricted to different regimes because of approximations invoked to solve the same transcendental equation. This paper shows the connection between the earlier studies by employing a general expression for the peak acceleration and obtains solutions to the transcendental equation without invoking the earlier approximations. Results are presented and compared with earlier studies where appropriate.

  1. Unifying decoherence and the Heisenberg Principle

    NASA Astrophysics Data System (ADS)

    Janssens, Bas

    2017-08-01

    We exhibit three inequalities involving quantum measurement, all of which are sharp and state independent. The first inequality bounds the performance of joint measurement. The second quantifies the trade-off between the measurement quality and the disturbance caused on the measured system. Finally, the third inequality provides a sharp lower bound on the amount of decoherence in terms of the measurement quality. This gives a unified description of both the Heisenberg uncertainty principle and the collapse of the wave function.

  2. Unifying theory for terrestrial research infrastructures

    NASA Astrophysics Data System (ADS)

    Mirtl, Michael

    2016-04-01

    The presentation will elaborate on basic steps needed for building a common theoretical base between Research Infrastructures focusing on terrestrial ecosystems. This theoretical base is needed for developing a better cooperation and integrating in the near future. An overview of different theories will be given and ways to a unifying approach explored. In the second step more practical implications of a theory-guided integration will be developed alongside the following guiding questions: • How do the existing and planned European environmental RIs map on a possible unifying theory on terrestrial ecosystems (covered structures and functions, scale; overlaps and gaps) • Can a unifying theory improve the consistent definition of RÍs scientific scope and focal science questions? • How could a division of tasks between RIs be organized in order to minimize parallel efforts? • Where concretely do existing and planned European environmental RIs need to interact to respond to overarching questions (top down component)? • What practical fora and mechanisms (across RIs) would be needed to bridge the gap between PI driven (bottom up) efforts and the centralistic RI design and operations?

  3. Can (should) theories of crowding be unified?

    PubMed

    Agaoglu, Mehmet N; Chung, Susana T L

    2016-12-01

    Objects in clutter are difficult to recognize, a phenomenon known as crowding. There is little consensus on the underlying mechanisms of crowding, and a large number of models have been proposed. There have also been attempts at unifying the explanations of crowding under a single model, such as the weighted feature model of Harrison and Bex (2015) and the texture synthesis model of Rosenholtz and colleagues (Balas, Nakano, & Rosenholtz, 2009; Keshvari & Rosenholtz, 2016). The goal of this work was to test various models of crowding and to assess whether a unifying account can be developed. Adopting Harrison and Bex's (2015) experimental paradigm, we asked observers to report the orientation of two concentric C-stimuli. Contrary to the predictions of their model, observers' recognition accuracy was worse for the inner C-stimulus. In addition, we demonstrated that the stimulus paradigm used by Harrison and Bex has a crucial confounding factor, eccentricity, which limits its usage to a very narrow range of stimulus parameters. Nevertheless, reporting the orientations of both C-stimuli in this paradigm proved very useful in pitting different crowding models against each other. Specifically, we tested deterministic and probabilistic versions of averaging, substitution, and attentional resolution models as well as the texture synthesis model. None of the models alone was able to explain the entire set of data. Based on these findings, we discuss whether the explanations of crowding can (should) be unified.

  4. The unified lunar control network: 1994 version

    NASA Technical Reports Server (NTRS)

    Davies, Merton E.; Colvin, Tim R.; Meyer, Donald L.; Nelson, Sandra

    1994-01-01

    The objective of the unified lunar control network is to combine a series of control networks into one compatible network with its origin at the center of mass of the Moon and its coordinates referred to the mean Earth/polar axis system. The initial unified system contained 130 nearside points from Apollo data and 1026 from telescopic data. It also contained ten Mariner 10 points. The total number of points was 1166. The current network includes modifications to the past network and extends the coverage. Coordinates of points north of the Apollo region have been recomputed based on Galileo images from the second Earth-Moon flyby. Coordinates of points in the Apollo region were held fixed; however, coordinates of points north of the Apollo region in the telescopic region and many Mariner 10 points were recomputed. All of the Mariner 10 points were remeasured and integrated into the network. Additional points in the Apollo region including the farside have been added. The unified network now contains 1478 points. Apollo, Mariner 10, and Galileo pictures all contained some farside points. The coordinates of the 1478 points are available only in the microfiche supplement to this paper.

  5. Can (should) theories of crowding be unified?

    PubMed Central

    Agaoglu, Mehmet N.; Chung, Susana T. L.

    2016-01-01

    Objects in clutter are difficult to recognize, a phenomenon known as crowding. There is little consensus on the underlying mechanisms of crowding, and a large number of models have been proposed. There have also been attempts at unifying the explanations of crowding under a single model, such as the weighted feature model of Harrison and Bex (2015) and the texture synthesis model of Rosenholtz and colleagues (Balas, Nakano, & Rosenholtz, 2009; Keshvari & Rosenholtz, 2016). The goal of this work was to test various models of crowding and to assess whether a unifying account can be developed. Adopting Harrison and Bex's (2015) experimental paradigm, we asked observers to report the orientation of two concentric C-stimuli. Contrary to the predictions of their model, observers' recognition accuracy was worse for the inner C-stimulus. In addition, we demonstrated that the stimulus paradigm used by Harrison and Bex has a crucial confounding factor, eccentricity, which limits its usage to a very narrow range of stimulus parameters. Nevertheless, reporting the orientations of both C-stimuli in this paradigm proved very useful in pitting different crowding models against each other. Specifically, we tested deterministic and probabilistic versions of averaging, substitution, and attentional resolution models as well as the texture synthesis model. None of the models alone was able to explain the entire set of data. Based on these findings, we discuss whether the explanations of crowding can (should) be unified. PMID:27936273

  6. Image segmentation with a unified graphical model.

    PubMed

    Zhang, Lei; Ji, Qiang

    2010-08-01

    We propose a unified graphical model that can represent both the causal and noncausal relationships among random variables and apply it to the image segmentation problem. Specifically, we first propose to employ Conditional Random Field (CRF) to model the spatial relationships among image superpixel regions and their measurements. We then introduce a multilayer Bayesian Network (BN) to model the causal dependencies that naturally exist among different image entities, including image regions, edges, and vertices. The CRF model and the BN model are then systematically and seamlessly combined through the theories of Factor Graph to form a unified probabilistic graphical model that captures the complex relationships among different image entities. Using the unified graphical model, image segmentation can be performed through a principled probabilistic inference. Experimental results on the Weizmann horse data set, on the VOC2006 cow data set, and on the MSRC2 multiclass data set demonstrate that our approach achieves favorable results compared to state-of-the-art approaches as well as those that use either the BN model or CRF model alone.

  7. The Mars Pathfinder ASI/MET Investigation

    NASA Astrophysics Data System (ADS)

    Schofield, J.; Crisp, D.; Labaw, C.; Mahoney, C.; Seiff, A.; Murphy, J.; Mihalov, J.; Wilson, G.; Haberle, R.; Tillman, J.; Barnes, J.

    1996-09-01

    On July 4th 1997, the Mars Pathfinder spacecraft will enter the martian atmosphere, land in the Ares Vallis region, and obtain the first in-situ measurements of the atmosphere and surface since the Viking mission more than 20 years ago. In addition to a Stereo Imager and an Alpha Proton X-Ray spectrometer, the Pathfinder Lander will carry an Atmospheric Structure and Meteorology (ASI/MET) experiment designed to study the atmosphere during the entry, descent, and landed phases of the mission. The ASI/MET package consists of 3 accelerometers, 4 thermocouple temperature sensors, a Tavis pressure sensor, and a 6-sector hot-wire wind sensor. The sensitivity limits of these instruments are respectively 2 micro g, 0.01 K, 0.25 micro bars, and 0.04 K. Measurements of deceleration in 3-orthogonal axes during entry will be used to determine a density, pressure, temperature profile for the upper atmosphere from 15-150 km, and direct measurements of temperature and pressure in the lower atmosphere will be made as the lander descends on its parachute. After landing, surface pressure measurements will continue and a meteorological mast will deploy. From this mast, atmospheric temperature will be measured 0.25, 0.5, & 1.0 m above the surface, and wind speed and direction will be determined at 1.1 m. Landed data will be acquired continuously for 1 year. Pathfinder is expected to make a significant contribution to Mars atmospheric science. It will provide a third in-situ atmospheric profile at a different season and local time to the earlier Viking profiles, and its surface observations will generate a climate record at the landing site with an order of magnitude better resolution than Viking. Because measurements will be made at different altitudes, they will also allow superior characterization of the martian surface boundary layer.

  8. Gastrointestinal malignancies harbor actionable MET exon 14 deletions

    PubMed Central

    Hong, Mineui; Kim, Sun Young; Jang, Jiryeon; Ahn, Soomin; Kang, So Young; Lee, Sujin; Kim, Seung Tae; Kim, Bogyou; Choi, Jaehyun; Kim, Kyung-Ah; Lee, Jiyun; Park, Charny; Park, Se Hoon; Park, Joon Oh; Lim, Ho Yeong; Kang, Won Ki; Park, Keunchil; Park, Young Suk; Kim, Kyoung-Mee

    2015-01-01

    Recently, MET exon 14 deletion (METex14del) has been postulated to be one potential mechanism for MET protein overexpression. We screened for the presence of METex14del transcript by multiplexed fusion transcript analysis using nCounter assay followed by confirmation with quantitative reverse transcription PCR with correlation to MET protein expression by immunohistochemistry (IHC) and MET amplification by fluorescence in situ hybridization (FISH). We extracted RNAs from 230 patients enrolled onto the prospective molecular profiling clinical trial (NEXT-1) (NCT02141152) between November 2013 and August 2014. Thirteen METex14del cases were identified including 3 gastric cancer, 4 colon cancer, 5 non-small cell lung cancer, and one adenocarcinoma of unknown primary. Of these 13 METex14del cases, 11 were MET IHC 3+ and 2 were 2+. Only one out of the 13 METex14del cases was MET amplified (MET/CEP ratio > 2.0). Growths of two (gastric, colon) METex14del+ patient tumor derived cell lines were profoundly inhibited by both MET tyrosine kinase inhibitors and a monoclonal antibody targeting MET. In conclusion, METex14del is a unique molecular aberration present in gastrointestinal (GI) malignancies corresponding with overexpression of MET protein but rarely with MET amplification. Substantial growth inhibition of METex14del+ patient tumor derived cell lines by several MET targeting drugs strongly suggests METex14del is a potential actionable driver mutation in GI malignancies. PMID:26375439

  9. [MET receptor inhibition: Hope against resistance to targeted therapies?

    PubMed

    Hochart, Audrey; Leblond, Pierre; Le Bourhis, Xuefen; Meignan, Samuel; Tulasne, David

    2017-02-01

    Overcoming the drug resistance remains a crucial issue in cancer treatment. For refractory patients, the use of MET receptor tyrosine kinase inhibitors seems to be hopeful. Indeed, important mechanisms underlying drug resistance argue for association of MET inhibitors with targeted therapies, both on first-line to prevent a primary resistance and on the second line to overcoming acquired resistance. Indeed, met gene amplification is the second most common alteration involved in acquired resistance to anti-epidermal growth factor receptor (EGFR) therapies in non-small cells lung cancer (NSCLC). Hypoxia, for its part, can activate MET transcription and amplifies HGF signaling resulting in MET activation, which could be involved in vascular endothelial growth factor (VEGF) inhibitors escape. In HER2 positive breast cancers, MET amplification may also induce tumor cells a hatch escape, resulting in secondary resistance. Finally, some patients with BRAF mutated melanoma exhibit primary resistance to BRAF inhibition by stromal HGF (ligand of MET) secretion resulting in MET receptor activation. Experimental data highlight the role of MET in primary and secondary resistance and encourage combined treatments including MET inhibitors. In this context, several promising clinical trials are in progress in numerous cancers (NSCLC, melanoma, breast cancer, glioblastoma…) using combination of anti-MET and other specific therapies targeting EGFR, BRAF, VEGF or HER2. This review summarizes the potential benefits that MET inhibition should provide to patients with cancer refractory to targeted therapies.

  10. The modified obstetric metabolic equivalent (MET): finding a MET that fits in pregnancy.

    PubMed

    Campbell, C G; Foster, R C; Lanningham-Foster, L M; Smith, K M

    2012-06-01

    The Compendium of Physical Activities (CPA) provides the energy expenditure (EE) for hundreds of daily activities reported in metabolic equivalents (MET). It remains to be determined if the metabolic changes of pregnancy alter the use of the CPA MET (METCPA) in this population. The energy cost of rest, activities of daily living (ADL; typing, folding laundry and sweeping) and treadmill walking [2.0, 2.5, 3.0 mph (0% incline), 3.0 mph (3% incline)] were compared with the METCPA from the 2000 and 2011 CPA in 30 pregnant women (10-14 weeks gestation) using indirect calorimetry (IC). The METCPA for each activity was compared against two measured IC values: METabsolute (3.5 ml O2/kg/min) and METratio (EEactivity/EErest). Means for both comparisons were tested by one-sample t-test. Measured MET correlated with the 2011 METCPA: METabsolute v. METCPA R 2 = 0.906, P < 0.0001; METratio v. METCPA R 2 = 0.861, P < 0.0001. Differences between measured MET values and the 2011 METCPA ranged from 16% underestimation to 48% overestimation. Using the absolute definition, the METCPA significantly overestimated the ADL (P < 0.0005); yet, no significant differences were found between walking at 0% grade and METCPA. Conversely, only folding laundry was significantly different with the ratio definition, whereas walking at a level grade was significantly underestimated (P < 0.0001). Similar observations were found using the 2000 CPA. The use of the METCPA to estimate EE in pregnant women can result in significant over- or underestimation, depending on the activity and the definition of the MET that is used.

  11. The Convergent Validity of Office Discipline Referrals with the CBCL-TRF.

    ERIC Educational Resources Information Center

    Nelson, J. Ron; Benner, Gregory J.; Reid, Robert C.; Epstein, Michael H.; Currin, DeAnn

    2002-01-01

    A study examined the office disciplinary referrals of 103 children who met the borderline or clinical cut-off scores of the Teacher Report Form. Results indicate there was a low-to-moderate degree of correspondence between children identified via a systematic gating procedure that included the form and office disciplinary referrals. (Contains…

  12. A unified physical model to explain Supercavity closure

    NASA Astrophysics Data System (ADS)

    Arndt, Roger; Karn, Ashish; Hong, Jiarong

    2014-11-01

    An insight into underlying physics behind supercavity closure is an important issue for the operation of underwater vehicles for a number of reasons viz. associated gas flow requirement with each closure regime, effect of cavity closure on the overall cavity behavior and collapse, differences between natural and ventilated supercavity closure etc. There have been several reports on supercavity closure since the 1950s and many empirical relationships governing different closure modes have been proposed by different authors. Yet, there is no universal agreement between results obtained at different experimental facilities. In some cases, contradictory observations have been made. In this talk, systematic investigations conducted into supercavity closure across a wide range of experimental conditions at the Saint Anthony Falls Laboratory (SAFL) are presented. A variety of closure mechanisms were observed including the ones widely reported in the literature, viz. twin vortex, re-entrant jet; new stable closure modes viz. quad vortex and interacting vortex and a host of transition closure modes. A hypothesis on the physical mechanism based on the pressure gradient across the cavity that determines the closure modes is proposed. Using this hypothesis and the control volume analysis at supercavity closure, we explain the observations from SAFL experiments as well as reconcile the observations reported by different researchers. The hypothesis explains the supercavity closure across different experimental facilities, at different blockage ratios and at different flow conditions. Thus, a unified understanding into supercavity closure from the viewpoint of fundamental physics is attempted. Supported by the Office Of Naval Research.

  13. Office of Minority Health

    MedlinePlus

    Skip Navigation Office of Minority Health A A A En Español Newsroom Contact Us Search: About OMH What We Do Resource Center Policy and Data ... Funding and Programs History Leadership Regional Staff State Minority Health Contacts Offices of Minority Health at HHS ...

  14. The Chief Diversity Officer

    ERIC Educational Resources Information Center

    Williams, Damon; Wade-Golden, Katrina

    2007-01-01

    Numerous institutions are moving toward the chief diversity officer model of leading and managing diversity in higher education. These officers carry formal administrative titles and ranks that range from vice president for institutional diversity to associate vice chancellor for diversity and climate and dean of diversity and academic engagement.…

  15. The Automated Office.

    ERIC Educational Resources Information Center

    Naclerio, Nick

    1979-01-01

    Clerical personnel may be able to climb career ladders as a result of office automation and expanded job opportunities in the word processing area. Suggests opportunities in an automated office system and lists books and periodicals on word processing for counselors and teachers. (MF)

  16. Planning for Office Automation.

    ERIC Educational Resources Information Center

    Sherron, Gene T.

    1982-01-01

    The steps taken toward office automation by the University of Maryland are described. Office automation is defined and some types of word processing systems are described. Policies developed in the writing of a campus plan are listed, followed by a section on procedures adopted to implement the plan. (Author/MLW)

  17. Office Safety (Part II).

    ERIC Educational Resources Information Center

    Swartz, Carl

    Toxic chemicals, noise, inadequate lighting, poor equipment design, smoking, and accidents pose serious health hazards for millions of office workers. Stress and boredom also contribute to the problems of safety. Workers should be on guard in the office for hazards, many of which are recognizable through common sense and patience. Workers must…

  18. Directors' and officers' liability.

    PubMed

    Thompson, H A

    1990-10-01

    Charities or business associations frequently ask physicians--due to their status in the community--to serve as directors or officers. Just as frequently, physicians agree to serve in those positions without fully understanding the responsibilities and possible liabilities they are assuming. This article describes the duties of directors and officers and the liabilities associated with the job.

  19. MET: roles in epithelial-mesenchymal transition and cancer stemness

    PubMed Central

    Jeon, Hye-Min

    2017-01-01

    In a number of cancers, deregulated MET pathway leads to aberrantly activated proliferative and invasive signaling programs that promote malignant transformation, cell motility and migration, angiogenesis, survival in hypoxia, and invasion. A better understanding of oncogenic MET signaling will help us to discover effective therapeutic approaches and to identify which tumors are likely to respond to MET-targeted cancer therapy. In this review, we will summarize the roles of MET signaling in cancer, with particular focus on epithelial-mesenchymal transition (EMT) and cancer stemness. Then, we will provide update on MET targeting agents and discuss the challenges that should be overcome for the development of an effective therapy. PMID:28164090

  20. Responses to the multitargeted MET/ALK/ROS1 inhibitor crizotinib and co-occurring mutations in lung adenocarcinomas with MET amplification or MET exon 14 skipping mutation.

    PubMed

    Jorge, Susan E; Schulman, Sol; Freed, Jason A; VanderLaan, Paul A; Rangachari, Deepa; Kobayashi, Susumu S; Huberman, Mark S; Costa, Daniel B

    2015-12-01

    Genomic aberrations involving ALK, ROS1 and MET can be driver oncogenes in lung adenocarcinomas. Identification of tyrosine kinase inhibitors (TKIs) with activity against these tumors and of preclinical systems to model response are warranted. We analyzed cases with lung adenocarcinomas for representative genomic aberrations, evaluated the response to the multitargeted MET/ALK/ROS1 crizotinib TKI in cases with MET aberrations and profiled lung cancer cell lines with the aforementioned genomic changes. Lung cancer cell lines with ALK rearrangement, ROS1 rearrangement or MET amplification had expected in vitro responses to crizotinib and the ALK/ROS1 TKI ceritinib. However, a commercially-available cell line with MET exon 14 skipping mutation and co-occurring PIK3CA-p.Glu545Lys mutation did not respond to crizotinib; suggesting the latter abrogated response. 10% of MET exon 14 skipping mutation co-occurred with PIK3CA mutation in the TCGA cohort. Putative crizotinib-responsive somatic mutations (ALK rearrangements, ROS1 rearrangements, high level MET amplification or MET exon 14 skipping mutations) were present in 10% of lung adenocarcinomas analyzed at our service and in 9.5% of the TCGA lung adenocarcinoma database. One patient each whose advanced tumors harbored high level MET amplification with wild-type PIK3CA or MET exon 14 skipping mutation with PIK3CA-p.Glu542Lys had significant responses to crizotinib; suggesting that PIK3CA co-mutation did not affect clinical response. Approximately 10% of lung adenocarcinomas harbor aberrations that are targetable using the approved multitargeted TKI crizotinib. MET exon 14 skipping mutation predicts for response to MET TKIs in human lung adenocarcinomas but co-occurrence of PIK3CA mutation needs to be better evaluated as a modifier of response to TKI therapy. MET TKIs should not be omitted from MET exon 14 skipping mutated tumors until further preclinical and clinical data can confirm or refute mechanisms of primary or

  1. Absence of tpr-met and expression of c-met in human gastric mucosa and carcinoma.

    PubMed

    Heideman, D A; Snijders, P J; Bloemena, E; Meijer, C J; Offerhaus, G J; Meuwissen, S G; Gerritsen, W R; Craanen, M E

    2001-08-01

    The c-met proto-oncogene, encoding the hepatocyte growth factor receptor, can be activated by various mechanisms. These include, among others, gene amplification with concomitant overexpression and the tpr-met oncogenic rearrangement. In the case of gastric cancer, contradictory results on the presence of the tpr-met oncogenic rearrangement have been published. The current study aimed therefore to assess the prevalence of tpr-met expression in Caucasian gastric adenocarcinomas, to evaluate the importance of this oncogene in their carcinogenesis. In addition, the level of c-met expression was determined, to evaluate the role of this alternative mode of activation of the proto-oncogene. A series of Caucasian gastric adenocarcinomas (n=43) and normal gastric mucosal samples (n=14) was analysed for tpr-met and c-met expression. Expression of tpr-met mRNA in the samples was performed by two reverse transcriptase polymerase chain reaction (RT-PCR) assays, with excellent correlation. The specificity of both methods was confirmed by direct sequencing of the PCR products of the MNNG-HOS cell line, which is known to contain the rearrangement. The level of c-met expression was assessed using semi-quantitative RT-PCR assays and immunohistochemistry (IHC). None of the normal gastric mucosal or gastric adenocarcinoma samples expressed tpr-met mRNA, as determined by both RT-PCR assays. Seventy per cent of the adenocarcinomas showed overexpression of c-met, according to elevated c-met mRNA levels, compared with the expression level of normal gastric mucosa. A significant correlation was found between the level of c-met mRNA and protein expression. In conclusion, these results strongly suggest that tpr-met activation does not play a role in Caucasian gastric carcinogenesis, while overexpression of the c-met gene occurs in the majority of Caucasian gastric adenocarcinomas. Copyright 2001 John Wiley & Sons, Ltd.

  2. Depleting MET-Expressing Tumor Cells by ADCC Provides a Therapeutic Advantage over Inhibiting HGF/MET Signaling.

    PubMed

    Hultberg, Anna; Morello, Virginia; Huyghe, Leander; De Jonge, Natalie; Blanchetot, Christophe; Hanssens, Valérie; De Boeck, Gitte; Silence, Karen; Festjens, Els; Heukers, Raimond; Roux, Benjamin; Lamballe, Fabienne; Ginestier, Christophe; Charafe-Jauffret, Emmanuelle; Maina, Flavio; Brouckaert, Peter; Saunders, Michael; Thibault, Alain; Dreier, Torsten; de Haard, Hans; Michieli, Paolo

    2015-08-15

    Hepatocyte growth factor (HGF) and its receptor MET represent validated targets for cancer therapy. However, HGF/MET inhibitors being explored as cancer therapeutics exhibit cytostatic activity rather than cytotoxic activity, which would be more desired. In this study, we engineered an antagonistic anti-MET antibody that, in addition to blocking HGF/MET signaling, also kills MET-overexpressing cancer cells by antibody-dependent cellular cytotoxicity (ADCC). As a control reagent, we engineered the same antibody in an ADCC-inactive form that is similarly capable of blocking HGF/MET activity, but in the absence of any effector function. In comparing these two antibodies in multiple mouse models of cancer, including HGF-dependent and -independent tumor xenografts, we determined that the ADCC-enhanced antibody was more efficacious than the ADCC-inactive antibody. In orthotopic mammary carcinoma models, ADCC enhancement was crucial to deplete circulating tumor cells and to suppress metastases. Prompted by these results, we optimized the ADCC-enhanced molecule for clinical development, generating an antibody (ARGX-111) with improved pharmacologic properties. ARGX-111 competed with HGF for MET binding, inhibiting ligand-dependent MET activity, downregulated cell surface expression of MET, curbing HGF-independent MET activity, and engaged natural killer cells to kill MET-expressing cancer cells, displaying MET-specific cytotoxic activity. ADCC assays confirmed the cytotoxic effects of ARGX-111 in multiple human cancer cell lines and patient-derived primary tumor specimens, including MET-expressing cancer stem-like cells. Together, our results show how ADCC provides a therapeutic advantage over conventional HGF/MET signaling blockade and generates proof-of-concept for ARGX-111 clinical testing in MET-positive oncologic malignancies.

  3. BDNF Val66Met polymorphism and goal-directed behavior in healthy elderly - evidence from auditory distraction.

    PubMed

    Getzmann, Stephan; Gajewski, Patrick D; Hengstler, Jan G; Falkenstein, Michael; Beste, Christian

    2013-01-01

    Aging affects the ability to focus attention on a given task and to ignore distractors. These functions subserve response control processes for which fronto-striatal networks have been shown to play an important role. Within these networks, the brain-derived-neurotrophic-factor (BDNF), which is known to underlie aging effects, plays a pivotal role. We investigated how cognitive subprocesses constituting a cycle of distraction, orientation and refocusing of attention are affected by the functional BDNF Val66Met polymorphism using event-related potentials (ERPs) in 122 healthy elderly. Using an auditory distraction paradigm we found that the Val/Val genotype confers a disadvantage to its carriers. This disadvantage was partly compensated by intensified attentional shifting mechanisms. It could be based on response selection processes being more vulnerable against interference from distractors in this genotype group. Processes reflecting transient sensory memory processes, or the re-orientation of attention were not affected by the BDNF Val66Met polymorphism, suggesting a higher importance of BDNF for mechanisms related to response control, than stimulus processing. The results add on recent literature showing that the Met allele confers some benefit to its carriers. We suggest an account for unifying different results of BDNF Val66Met association studies in executive functions, based on the role of BDNF in fronto-striatal circuits.

  4. Electricity, Relativity and Magnetism: A Unified Text

    NASA Astrophysics Data System (ADS)

    Craik, Derek J.

    2003-09-01

    Electricity, Relativity and Magnetism: A Unified Text presents the first complete and systematic derivation of the principles of magnetism and electromagnetism from Coulomb s law and the theory of special relativity alone. Most books on magnetism introduce the subject in terms of experimental observations, as if magnetism were distinct from, albeit associated with, electricity. The topic of relativity is often mentioned, but almost as an afterthought, rather than as a crucial element of the argument. In this new book from Dr Derek Craik, the important links between electricity and magnetism, via special relativity, are emphasized, leading the reader to a more meaningful and profound understanding of the subject. Electricity, Relativity and Magnetism: A Unified Text gives a simple and brief review of Einstein s special theory of relativity, emphasizing force transformations. An outline of electrostatics, Coulomb s law and its consequences, is also given and is shown to lead to the basis of magnetostatics. Time-dependent electromagnetic effects are introduced naturally via the transformation equations for fields and for potentials, and Maxwell s equations are systematically derived. Magnetic dipoles and magnetization are shown to arise on transforming electric dipoles and polarizations. The author next discusses the application of the theory to practical magnetic calculations, and finally goes on to introduce the quantum theory of magnetism. The concept of spin is introduced, leading to spin statics and magnetic ordering, and spin dynamics and resonances. An account of crystal field theory is included. All whose work and research involves the understanding of magnetic phenomena will find Electricity, Relativity and Magnetism: A Unified Text an invaluable resource which will enhance and deepen their understanding of the subject.

  5. Unified Field Mechanics: A Brief Introduction

    NASA Astrophysics Data System (ADS)

    Amoroso, Richard L.

    Recently we hear more and more physicists saying, `spacetime is doomed', `spacetime is a mirage', the `end of spacetime', `spacetime is not fundamental but emergent' etc. "Henceforth space by itself and time by itself are doomed to fade into the mere shadows, and only a union of the two will preserve an independent reality." - 1908 Hermann Minkowski. We have come full circle from the time of Minkowski's 1908 statement to the brink of an imminent new age of discovery. The basis of our understanding of the natural world has evolved in modern times from Newtonian Mechanics to the 2nd regime of Quantum Mechanics; and now to the threshold of a 3rd regime - Unified Field Mechanics (UFM). The Planck scale stochastic quantum realm can no longer be considered the `basement' or fundamental level of reality. As hard as quantum reality was to imagine so is the fact that the quantum domain is a manifold of finite radius; and that the `sacrosanct - indelible' Quantum Uncertainty Principle can now be surmounted. For decades main stream physicists have been stymied by efforts to reconcile General Relativity with Quantum Mechanics. The stumbling block lies with the two theories conflicting views of space and time: For quantum theory, space and time offer a fixed backcloth against which particles move. In Einstein's relativities, space and time are not only inextricably linked, but the resultant spacetime is warped by the matter within it. In our nascent UFM paradigm for arcane reasons the quantum manifold is not the regime of integration with gravity; it is instead integrated with the domain of the unified field where the forces of nature are deemed to unify. We give a simplistic survey of the fundamental premises of UFM and summarize experimental protocols to falsify the model at this stage of the paradigm's development.

  6. 3D RoboMET Characterization

    SciTech Connect

    Madison, Jonathan D.; Susan, Donald F.; Kilgo, Alice C.

    2015-10-01

    The goal of this project is to generate 3D microstructural data by destructive and non-destructive means and provide accompanying characterization and quantitative analysis of such data. This work is a continuing part of a larger effort to relate material performance variability to microstructural variability. That larger effort is called “Predicting Performance Margins” or PPM. In conjunction with that overarching initiative, the RoboMET.3D™ is a specific asset of Center 1800 and is an automated serialsectioning system for destructive analysis of microstructure, which is called upon to provide direct customer support to 1800 and non-1800 customers. To that end, data collection, 3d reconstruction and analysis of typical and atypical microstructures have been pursued for the purposes of qualitative and quantitative characterization with a goal toward linking microstructural defects and/or microstructural features with mechanical response. Material systems examined in FY15 include precipitation hardened 17-4 steel, laser-welds of 304L stainless steel, thermal spray coatings of 304L and geological samples of sandstone.

  7. An under-met and over-met expectations model of employee reactions to merit raises.

    PubMed

    Schaubroeck, John; Shaw, Jason D; Duffy, Michelle K; Mitra, Atul

    2008-03-01

    The authors developed a model of how raise expectations influence the relationship between merit pay raises and employee reactions and tested it using a sample of hospital employees. Pay-for-performance (PFP) perceptions were consistently related to personal reactions (e.g., pay raise happiness, pay-level satisfaction, and turnover intentions). Merit pay raises were strongly related to reactions only among employees with high raise expectations and high PFP perceptions. The interactive effects of under-met/over-met expectations and PFP perceptions were mediated by the extent to which participants saw the raise as generous and they were happy with the raises they received. The authors discuss the implications of these findings for expectation-fulfillment theories, merit pay research, and the administration of incentives.

  8. [Labor migration in a unified Germany].

    PubMed

    Raffelhuschen, B

    1993-01-01

    "In this paper we illustrated future migration of labor within the old and new 'Lander' of unified Germany.... Our setting was a microbased general equilibrium model. It was shown that the diverging economic conditions within reunified Germany heavily distort the choice of location of German workers. If the transfer of capital and technology does not equalize the large discrepancies rapidly, net migration of eastern workers into the west of close to 12 percent of the eastern work force by 1993, and 16 percent by 1995, is to be expected." (SUMMARY IN ENG) excerpt

  9. Interactive analysis environment of unified accelerator libraries

    NASA Astrophysics Data System (ADS)

    Fine, V.; Malitsky, N.; Talman, R.

    2006-04-01

    Unified Accelerator Libraries (UAL, http://www.ual.bnl.gov) software is an open accelerator simulation environment addressing a broad spectrum of accelerator tasks ranging from efficient online-oriented modeling to full-scale realistic beam dynamics studies. The paper introduces a new package integrating UAL simulation algorithms with the QT-based Graphical User Interface and the ROOT data analysis and visualization framework ( http://root.cern.ch). The primary user application is implemented as an interactive and configurable Accelerator Physics Player. Its interface to visualization components is based on the QT layer ( http://root.bnl.gov) supported by the STAR experiment.

  10. Management of the Unified Astronomy Thesaurus

    NASA Astrophysics Data System (ADS)

    Frey, K.; Erdmann, C.; Accomazzi, A.; Rubin, L.; Biemesderfer, C.; Gray, N.; Soles, J.

    2015-04-01

    The Unified Astronomy Thesaurus (UAT) is an open, interoperable, and community-supported thesaurus of astronomical and astrophysical concepts and their relationships. Management of the UAT is based on a community-supported approach. This will ensure that the thesaurus stays current by allowing users to suggest an addition or revision. These suggestions will then be subjected to a thorough expert review process before being accepted for addition to the UAT or rejected. Many leading astronomical institutions, professional associations, journal publishers, learned societies, and data repositories support the UAT as a standard astronomical terminology.

  11. SUDS: The seismic unified data system

    NASA Astrophysics Data System (ADS)

    Ward, Peter L.

    Our ability to collect high-quality digital data is increasing much more rapidly than our ability to process it. This is partly due to the revolution in digital technology and partly to increased teamwork in building equipment and carrying out major projects such as those fostered in seismology by the IRIS Consortium (Incorporated Research Institutions for Seismology). The need is now great for a similar level of teamwork in data processing. The Seismic Unified Data System (SUDS) is a foundation suitable for such teamwork in all types of seismic processing, from studies of earthquakes to discrimination of explosions to reflection and refraction studies.

  12. Unified framework for systematic loop transformations

    SciTech Connect

    Lu, L.C.; Chen, M.

    1990-10-01

    This paper presents a formal mathematical framework which unifies the existing loop transformations. This framework also includes more general classes of loop transformations, which can extract more parallelism from a class of programs than the existing techniques. We classify schedules into three classes: uniform, subdomain-variant, and statement-variant. Viewing from the degree of parallelism to be gained by loop transformation, the schedules can also be classified as single-sequential level, multiple-sequential level, and mixed schedules. We also illustrate the usefulness of the more general loop transformation with an example program.

  13. Unified formalism for nonautonomous mechanical systems

    NASA Astrophysics Data System (ADS)

    Barbero-Liñán, María; Echeverría-Enríquez, Arturo; Diego, David Martín de; Muñoz-Lecanda, Miguel C.; Román-Roy, Narciso

    2008-06-01

    We present a unified geometric framework for describing both the Lagrangian and Hamiltonian formalisms of regular and nonregular time-dependent mechanical systems, which is based on the approach of Skinner and Rusk ["Generalized Hamiltonian dynamics I. Formulation on T*Q⊗TQ," J. Math. Phys. 24, 2589 (1983)]. The dynamical equations of motion and their compatibility and consistency are carefully studied, making clear that all the characteristics of the Lagrangian and the Hamiltonian formalisms are recovered in this formulation. As an example, a semidiscretization of the nonlinear wave equation is studied, proving the applicability of the proposed formalism.

  14. A unified analysis and design procedure for a standardized control module for dc-dc switching regulators

    NASA Technical Reports Server (NTRS)

    Lee, F. C.; Yu, Y.; Mahmoud, M. F.

    1980-01-01

    Three basic switching regulators: buck, boost, and buck/boost, employing a multi-loop control module (SCM) were characterized by a common small signal block diagram. Employing the unified model, regulator performances such as stability, audiosusceptibility, output impedance and step load transient are analyzed and key performance indexes are expressed in simple analytical forms. More importantly, the performance characteristics of all three regulators are shown to enjoy common properties due to the unique SCM control scheme which nullifies the positive zero and provides adaptive compensation to the moving poles of the boost and buck/boost converters. This allows a simple unified design procedure to be devised for selecting the key SCM control parameters for an arbitrarily given power stage configuration and parameter values, such that all regulator performance specifications can be met and optimized concurrently in a single design attempt.

  15. Office-based anesthesia.

    PubMed

    Treasure, Trevor; Bennett, Jeffrey

    2007-02-01

    The practice of office-based oral and maxillofacial surgery is continuously expanding and involves the management of a diverse population in regards to the surgical procedures performed within the office and the age and medical health of the patients treated within the office. Comfort, cooperation, and hemodynamic stability are critical to satisfactorily accomplishing the surgical procedure. Various anesthetic techniques are used, including local anesthesia, anxiolysis, analgesia and sedation, and general anesthesia. The topic is vast and too extensive to be fully discussed in this article. The intent of this article is to provide a discussion of some fundamental concepts that can optimize anesthetic safety and care.

  16. Control of a Unified Chaotic System via Single Variable Feedback

    NASA Astrophysics Data System (ADS)

    Guo, Rong-Wei; Vincent E., U.

    2009-09-01

    Based on the LaSalle invariance principle, we propose a simple adaptive-feedback for controlling the unified chaotic system. We show explicitly with numerical proofs that our method can easily achieve the control of chaos in the unified chaotic system using only a single variable feedback. The present controller, to our knowledge, is the simplest control scheme for controlling a unified chaotic system.

  17. 76 FR 13272 - Branch Offices

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-10

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE TREASURY Office of Thrift Supervision Branch Offices AGENCY: Office of Thrift Supervision (OTS), Treasury. ACTION... 1995, 44 U.S.C. 3507. The Office of Thrift Supervision within the Department of the Treasury...

  18. Office of the Chief Financial Officer Annual Report 2009

    SciTech Connect

    Fernandez, Jeffrey

    2009-12-15

    Presented is the 2009 Chief Financial Officer's Annual Report. The data included in this report has been compiled from the Budget Office, the Controller, Procurement and Property Management and the Sponsored Projects Office.

  19. 12. Exterior of main offices, stock room and payroll offices ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Exterior of main offices, stock room and payroll offices view from yard (middle building formerly mold loft #1). Building at left is stock room desk and offices. - Barbour Boat Works, Tryon Palace Drive, New Bern, Craven County, NC

  20. Unifying hydrotropy under Gibbs phase rule.

    PubMed

    Shimizu, Seishi; Matubayasi, Nobuyuki

    2017-09-13

    The task of elucidating the mechanism of solubility enhancement using hydrotropes has been hampered by the wide variety of phase behaviour that hydrotropes can exhibit, encompassing near-ideal aqueous solution, self-association, micelle formation, and micro-emulsions. Instead of taking a field guide or encyclopedic approach to classify hydrotropes into different molecular classes, we take a rational approach aiming at constructing a unified theory of hydrotropy based upon the first principles of statistical thermodynamics. Achieving this aim can be facilitated by the two key concepts: (1) the Gibbs phase rule as the basis of classifying the hydrotropes in terms of the degrees of freedom and the number of variables to modulate the solvation free energy; (2) the Kirkwood-Buff integrals to quantify the interactions between the species and their relative contributions to the process of solubilization. We demonstrate that the application of the two key concepts can in principle be used to distinguish the different molecular scenarios at work under apparently similar solubility curves observed from experiments. In addition, a generalization of our previous approach to solutes beyond dilution reveals the unified mechanism of hydrotropy, driven by a strong solute-hydrotrope interaction which overcomes the apparent per-hydrotrope inefficiency due to hydrotrope self-clustering.

  1. A Unified Theoretical Framework for Cognitive Sequencing

    PubMed Central

    Savalia, Tejas; Shukla, Anuj; Bapi, Raju S.

    2016-01-01

    The capacity to sequence information is central to human performance. Sequencing ability forms the foundation stone for higher order cognition related to language and goal-directed planning. Information related to the order of items, their timing, chunking and hierarchical organization are important aspects in sequencing. Past research on sequencing has emphasized two distinct and independent dichotomies: implicit vs. explicit and goal-directed vs. habits. We propose a theoretical framework unifying these two streams. Our proposal relies on brain's ability to implicitly extract statistical regularities from the stream of stimuli and with attentional engagement organizing sequences explicitly and hierarchically. Similarly, sequences that need to be assembled purposively to accomplish a goal require engagement of attentional processes. With repetition, these goal-directed plans become habits with concomitant disengagement of attention. Thus, attention and awareness play a crucial role in the implicit-to-explicit transition as well as in how goal-directed plans become automatic habits. Cortico-subcortical loops basal ganglia-frontal cortex and hippocampus-frontal cortex loops mediate the transition process. We show how the computational principles of model-free and model-based learning paradigms, along with a pivotal role for attention and awareness, offer a unifying framework for these two dichotomies. Based on this framework, we make testable predictions related to the potential influence of response-to-stimulus interval (RSI) on developing awareness in implicit learning tasks. PMID:27917146

  2. Toward a unifying framework for evolutionary processes

    PubMed Central

    Paixão, Tiago; Badkobeh, Golnaz; Barton, Nick; Çörüş, Doğan; Dang, Duc-Cuong; Friedrich, Tobias; Lehre, Per Kristian; Sudholt, Dirk; Sutton, Andrew M.; Trubenová, Barbora

    2015-01-01

    The theory of population genetics and evolutionary computation have been evolving separately for nearly 30 years. Many results have been independently obtained in both fields and many others are unique to its respective field. We aim to bridge this gap by developing a unifying framework for evolutionary processes that allows both evolutionary algorithms and population genetics models to be cast in the same formal framework. The framework we present here decomposes the evolutionary process into its several components in order to facilitate the identification of similarities between different models. In particular, we propose a classification of evolutionary operators based on the defining properties of the different components. We cast several commonly used operators from both fields into this common framework. Using this, we map different evolutionary and genetic algorithms to different evolutionary regimes and identify candidates with the most potential for the translation of results between the fields. This provides a unified description of evolutionary processes and represents a stepping stone towards new tools and results to both fields. PMID:26215686

  3. Minimal realistic SU(5) Grand Unified Theory

    NASA Astrophysics Data System (ADS)

    Assad, Nima

    2016-03-01

    Despite making predictions in unprecedented agreement with experiment, such as the magnetic dipole moment of the electron to one part in a billion, the experimental confirmation of neutrino flavor oscillations, and thus of massive neutrinos, implies that the Standard Model (SM) of particle physics is incomplete. An extension of the SM, which retains its low energy predictions while accounting for massive neutrinos, is achieved through the introduction of the dimension 5 Weinberg operator and its associated energy scale above the electroweak (102 GeV), but below the Planck scale (1019 GeV). The Beyond Standard Model (BSM) class of Grand Unified Theories (GUTs) implicates such a scale (1016 GeV) in the unification of the three SM gauge couplings, thus making the origin of neutrino mass a theoretically appealing probe into particle behavior at energies currently inaccessible experimentally. Here, we compare the 24F and 15H extensions of the Georgi-Glashow SU(5) GUT to accommodate massive neutrinos and to unify SM gauge couplings while minimizing the theory's additional field content. Using the Monte Carlo event generator MadGraph, each extension is found to produce distinct signatures at the run II of the LHC.

  4. A unifying description of dark energy

    NASA Astrophysics Data System (ADS)

    Gleyzes, Jérôme; Langlois, David; Vernizzi, Filippo

    2014-01-01

    We review and extend a novel approach that we recently introduced, to describe general dark energy or scalar-tensor models. Our approach relies on an Arnowitt-Deser-Misner (ADM) formulation based on the hypersurfaces where the underlying scalar field is uniform. The advantage of this approach is that it can describe in the same language and in a minimal way a vast number of existing models, such as quintessence, F(R) theories, scalar tensor theories, their Horndeski extensions and beyond. It also naturally includes Horava-Lifshitz theories. As summarized in this review, our approach provides a unified treatment of the linear cosmological perturbations about a Friedmann-Lemaître-Robertson-Walker (FLRW) universe, obtained by a systematic expansion of our general action up to quadratic order. This shows that the behavior of these linear perturbations is generically characterized by five time-dependent functions. We derive the full equations of motion in the Newtonian gauge. In the Horndeski case, we obtain the equation of state for dark energy perturbations in terms of these functions. Our unifying description thus provides the simplest and most systematic way to confront theoretical models with current and future cosmological observations.

  5. Simplification of the unified gas kinetic scheme

    NASA Astrophysics Data System (ADS)

    Chen, Songze; Guo, Zhaoli; Xu, Kun

    2016-08-01

    The unified gas kinetic scheme (UGKS) is an asymptotic preserving (AP) scheme for kinetic equations. It is superior for transition flow simulation and has been validated in the past years. However, compared to the well-known discrete ordinate method (DOM), which is a classical numerical method solving the kinetic equations, the UGKS needs more computational resources. In this study, we propose a simplification of the unified gas kinetic scheme. It allows almost identical numerical cost as the DOM, but predicts numerical results as accurate as the UGKS. In the simplified scheme, the numerical flux for the velocity distribution function and the numerical flux for the macroscopic conservative quantities are evaluated separately. The equilibrium part of the UGKS flux is calculated by analytical solution instead of the numerical quadrature in velocity space. The simplification is equivalent to a flux hybridization of the gas kinetic scheme for the Navier-Stokes (NS) equations and the conventional discrete ordinate method. Several simplification strategies are tested, through which we can identify the key ingredient of the Navier-Stokes asymptotic preserving property. Numerical tests show that, as long as the collision effect is built into the macroscopic numerical flux, the numerical scheme is Navier-Stokes asymptotic preserving, regardless the accuracy of the microscopic numerical flux for the velocity distribution function.

  6. Inelastic mechanics: A unifying principle in biomechanics.

    PubMed

    Gralka, Matti; Kroy, Klaus

    2015-11-01

    Many soft materials are classified as viscoelastic. They behave mechanically neither quite fluid-like nor quite solid-like - rather a bit of both. Biomaterials are often said to fall into this class. Here, we argue that this misses a crucial aspect, and that biomechanics is essentially damage mechanics, at heart. When deforming an animal cell or tissue, one can hardly avoid inducing the unfolding of protein domains, the unbinding of cytoskeletal crosslinkers, the breaking of weak sacrificial bonds, and the disruption of transient adhesions. We classify these activated structural changes as inelastic. They are often to a large degree reversible and are therefore not plastic in the proper sense, but they dissipate substantial amounts of elastic energy by structural damping. We review recent experiments involving biological materials on all scales, from single biopolymers over cells to model tissues, to illustrate the unifying power of this paradigm. A deliberately minimalistic yet phenomenologically very rich mathematical modeling framework for inelastic biomechanics is proposed. It transcends the conventional viscoelastic paradigm and suggests itself as a promising candidate for a unified description and interpretation of a wide range of experimental data. This article is part of a Special Issue entitled: Mechanobiology.

  7. Toward a unifying framework for evolutionary processes.

    PubMed

    Paixão, Tiago; Badkobeh, Golnaz; Barton, Nick; Çörüş, Doğan; Dang, Duc-Cuong; Friedrich, Tobias; Lehre, Per Kristian; Sudholt, Dirk; Sutton, Andrew M; Trubenová, Barbora

    2015-10-21

    The theory of population genetics and evolutionary computation have been evolving separately for nearly 30 years. Many results have been independently obtained in both fields and many others are unique to its respective field. We aim to bridge this gap by developing a unifying framework for evolutionary processes that allows both evolutionary algorithms and population genetics models to be cast in the same formal framework. The framework we present here decomposes the evolutionary process into its several components in order to facilitate the identification of similarities between different models. In particular, we propose a classification of evolutionary operators based on the defining properties of the different components. We cast several commonly used operators from both fields into this common framework. Using this, we map different evolutionary and genetic algorithms to different evolutionary regimes and identify candidates with the most potential for the translation of results between the fields. This provides a unified description of evolutionary processes and represents a stepping stone towards new tools and results to both fields. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

  8. A Unified Theoretical Framework for Cognitive Sequencing.

    PubMed

    Savalia, Tejas; Shukla, Anuj; Bapi, Raju S

    2016-01-01

    The capacity to sequence information is central to human performance. Sequencing ability forms the foundation stone for higher order cognition related to language and goal-directed planning. Information related to the order of items, their timing, chunking and hierarchical organization are important aspects in sequencing. Past research on sequencing has emphasized two distinct and independent dichotomies: implicit vs. explicit and goal-directed vs. habits. We propose a theoretical framework unifying these two streams. Our proposal relies on brain's ability to implicitly extract statistical regularities from the stream of stimuli and with attentional engagement organizing sequences explicitly and hierarchically. Similarly, sequences that need to be assembled purposively to accomplish a goal require engagement of attentional processes. With repetition, these goal-directed plans become habits with concomitant disengagement of attention. Thus, attention and awareness play a crucial role in the implicit-to-explicit transition as well as in how goal-directed plans become automatic habits. Cortico-subcortical loops basal ganglia-frontal cortex and hippocampus-frontal cortex loops mediate the transition process. We show how the computational principles of model-free and model-based learning paradigms, along with a pivotal role for attention and awareness, offer a unifying framework for these two dichotomies. Based on this framework, we make testable predictions related to the potential influence of response-to-stimulus interval (RSI) on developing awareness in implicit learning tasks.

  9. DataSpread: Unifying Databases and Spreadsheets.

    PubMed

    Bendre, Mangesh; Sun, Bofan; Zhang, Ding; Zhou, Xinyan; Chang, Kevin ChenChuan; Parameswaran, Aditya

    2015-08-01

    Spreadsheet software is often the tool of choice for ad-hoc tabular data management, processing, and visualization, especially on tiny data sets. On the other hand, relational database systems offer significant power, expressivity, and efficiency over spreadsheet software for data management, while lacking in the ease of use and ad-hoc analysis capabilities. We demonstrate DataSpread, a data exploration tool that holistically unifies databases and spreadsheets. It continues to offer a Microsoft Excel-based spreadsheet front-end, while in parallel managing all the data in a back-end database, specifically, PostgreSQL. DataSpread retains all the advantages of spreadsheets, including ease of use, ad-hoc analysis and visualization capabilities, and a schema-free nature, while also adding the advantages of traditional relational databases, such as scalability and the ability to use arbitrary SQL to import, filter, or join external or internal tables and have the results appear in the spreadsheet. DataSpread needs to reason about and reconcile differences in the notions of schema, addressing of cells and tuples, and the current "pane" (which exists in spreadsheets but not in traditional databases), and support data modifications at both the front-end and the back-end. Our demonstration will center on our first and early prototype of the DataSpread, and will give the attendees a sense for the enormous data exploration capabilities offered by unifying spreadsheets and databases.

  10. DataSpread: Unifying Databases and Spreadsheets

    PubMed Central

    Bendre, Mangesh; Sun, Bofan; Zhang, Ding; Zhou, Xinyan; Chang, Kevin ChenChuan; Parameswaran, Aditya

    2015-01-01

    Spreadsheet software is often the tool of choice for ad-hoc tabular data management, processing, and visualization, especially on tiny data sets. On the other hand, relational database systems offer significant power, expressivity, and efficiency over spreadsheet software for data management, while lacking in the ease of use and ad-hoc analysis capabilities. We demonstrate DataSpread, a data exploration tool that holistically unifies databases and spreadsheets. It continues to offer a Microsoft Excel-based spreadsheet front-end, while in parallel managing all the data in a back-end database, specifically, PostgreSQL. DataSpread retains all the advantages of spreadsheets, including ease of use, ad-hoc analysis and visualization capabilities, and a schema-free nature, while also adding the advantages of traditional relational databases, such as scalability and the ability to use arbitrary SQL to import, filter, or join external or internal tables and have the results appear in the spreadsheet. DataSpread needs to reason about and reconcile differences in the notions of schema, addressing of cells and tuples, and the current “pane” (which exists in spreadsheets but not in traditional databases), and support data modifications at both the front-end and the back-end. Our demonstration will center on our first and early prototype of the DataSpread, and will give the attendees a sense for the enormous data exploration capabilities offered by unifying spreadsheets and databases. PMID:26900487

  11. Office proctology and sigmoidoscopy.

    PubMed

    Fraser, A

    1990-05-01

    Proctoscopy and sigmoidoscopy are readily acquired skills and should be routine office procedures for general practitioners. Correct positioning of the patient is of utmost importance to a successful examination.

  12. Planning for Office Automation.

    ERIC Educational Resources Information Center

    Mick, Colin K.

    1983-01-01

    Outlines a practical approach to planning for office automation termed the "Focused Process Approach" (the "what" phase, "how" phase, "doing" phase) which is a synthesis of the problem-solving and participatory planning approaches. Thirteen references are provided. (EJS)

  13. National Vaccine Program Office

    MedlinePlus

    ... Track Your Community Vaccine Safety Scientific Agenda Newsletter Sign Up Subscribe to newsletter updates for the latest information ... National Vaccine Program Office. Email Connect With NVPO Sign Up for NVPO Updates To sign up for updates ...

  14. EPA's Industry Assistance Office.

    ERIC Educational Resources Information Center

    Ruggiero, Michael A.

    1979-01-01

    The EPA's Industry Assistance Office, established under the Toxic Substance Control Act to help manufacturers and processors of chemical substances and mixtures to comply with the Act, is described. (BB)

  15. MetRxn: a knowledgebase of metabolites and reactions spanning metabolic models and databases

    PubMed Central

    2012-01-01

    Background Increasingly, metabolite and reaction information is organized in the form of genome-scale metabolic reconstructions that describe the reaction stoichiometry, directionality, and gene to protein to reaction associations. A key bottleneck in the pace of reconstruction of new, high-quality metabolic models is the inability to directly make use of metabolite/reaction information from biological databases or other models due to incompatibilities in content representation (i.e., metabolites with multiple names across databases and models), stoichiometric errors such as elemental or charge imbalances, and incomplete atomistic detail (e.g., use of generic R-group or non-explicit specification of stereo-specificity). Description MetRxn is a knowledgebase that includes standardized metabolite and reaction descriptions by integrating information from BRENDA, KEGG, MetaCyc, Reactome.org and 44 metabolic models into a single unified data set. All metabolite entries have matched synonyms, resolved protonation states, and are linked to unique structures. All reaction entries are elementally and charge balanced. This is accomplished through the use of a workflow of lexicographic, phonetic, and structural comparison algorithms. MetRxn allows for the download of standardized versions of existing genome-scale metabolic models and the use of metabolic information for the rapid reconstruction of new ones. Conclusions The standardization in description allows for the direct comparison of the metabolite and reaction content between metabolic models and databases and the exhaustive prospecting of pathways for biotechnological production. This ever-growing dataset currently consists of over 76,000 metabolites participating in more than 72,000 reactions (including unresolved entries). MetRxn is hosted on a web-based platform that uses relational database models (MySQL). PMID:22233419

  16. Assessing the NWP performance of different representations of convection using limited-area Unified Model forecasts for South East Asia.

    NASA Astrophysics Data System (ADS)

    Webster, Stuart

    2017-04-01

    Since the end of 2016 the Met Office has been running real-time limited-area Unified Model (UM) forecasts for South East Asia as part of a UK government Newton fund project. Five-day forecasts are run twice daily over South East Asia - specifically, over a rectangular domain spanning 90E to 154E and 17S to 25N. Four different configurations, each of which represent convection in a different way, are run for each forecast time. Two of these use a 10 km grid-length and, since their configurations follow those defined for the global versions of the UM, atmospheric convection is parametrized. The first configuration is the same as the current global forecast model (the sixth Global Atmosphere (GA6) configuration), whilst the other is an experimental configuration which includes a number of changes to the convection parametrization, most notably a prognostic entrainment scheme which helps to improve the diurnal cycle of convection. The other two configurations use a 4.4 km grid-length and represent convection explicitly. These configurations are based on the operational convective-scale model used over the UK (known at the UKV), but additionally include a number of tropics-specific changes developed and tested over the last couple of years. The representation of convection in these two configurations differs primarily through the large-scale cloud scheme; the first uses the diagnostic "Smith" scheme whilst the second uses the prognostic "PC2" cloud scheme, which has been used in the global versions of the UM for a number of years. In this presentation results will be presented which illustrate the impact of the different representation of convection in these four real-time forecast configurations. In particular, the sensitivity of various aspects of the forecast rainfall will be examined, including the rainfall distribution and pdfs, the ability of the models to capture extreme events and the timing of the diurnal cycle. Furthermore, an objective assessment of the

  17. MET Inhibition in Clear Cell Renal Cell Carcinoma

    PubMed Central

    Xie, Zuoquan; Lee, Young H.; Boeke, Marta; Jilaveanu, Lucia B.; Liu, Zongzhi; Bottaro, Donald P.; Kluger, Harriet M.; Shuch, Brian

    2016-01-01

    Background: Clear cell renal cell carcinoma (ccRCC) is the most lethal form of kidney cancer. Small molecule VEGFR inhibitors are widely used but are not curative and various resistance mechanisms such as activation of the MET pathway have been described. Dual MET/VEGFR2 inhibitors have recently shown clinical benefit but limited preclinical data evaluates their effects in ccRCC. Methods: An interrogation of the Cancer Genome Atlas (TCGA) dataset was performed to evaluate oncogenic alterations in the MET/VEGFR2 pathway. We evaluated the in vitro effects of Cabozantinib, a dual MET/VEGFR2 inhibitor, using a panel of ccRCC cell lines. Drug effects of cell viability and proliferation, migration, cell scatter, anchorage independent growth, and downstream MET/VEGFR2 signaling pathways were assessed. Results: Twelve percent of TCGA cases had possible MET/HGF oncogenic alterations with co-occurrence noted (p<0.001). MET/HGF altered cases had worse overall survival (p=0.044). Cabozantinib was a potent inhibitor of MET and VEGFR2 in vitro in our cell line panel. PI3K, MAPK and mTOR pathways were also suppressed by cabozantinib, however the effects on cell viability in vitro were modest. At nanomolar concentrations of cabozantinib, HGF-stimulated migration, invasion, cellular scattering and soft agar colony formation were inhibited. Conclusions: We provide further preclinical rationale for dual MET/VEGFR2 inhibition in ccRCC. While the MET pathway is implicated in VEGFR resistance, dual inhibitors may have direct anti-tumor effects in a patient subset with evidence of MET pathway involvement. Cabozantinib is a potent dual MET/VEGFR2 inhibitor, significantly inhibits cell migration and invasion in vitro and likely has anti-angiogenic effects similar to other VEGFR tyrosine kinase inhibitors. Future work involving in vivo models will be useful to better define mechanisms of potential anti-tumor activity. PMID:27390595

  18. Training with Simulated Team Members (Trainen met Gesimuleerde Teamieden).

    DTIC Science & Technology

    2007-11-02

    can only be integrated when team members are training together. And this improves the transfer of knowledge and skills. Practising with simulated team...And this improves the transfer of knowledge and skills. Practising with simulated team members offers the advantages of training apart and training...respectievelijke taken perfect uitvoeren. In dat geval is trainen met gesimuleerde teamleden vergelijkbaar met trainen met ervaren teamleden (vgl

  19. Effective implementation of novel MET pharmacodynamic assays in translational studies

    PubMed Central

    Navas, Tony; Herrick, William G.; Hollingshead, Melinda G.; Bottaro, Donald P.; Doroshow, James H.; Parchment, Ralph E.

    2017-01-01

    MET tyrosine kinase (TK) dysregulation is significantly implicated in many types of cancer. Despite over 20 years of drug development to target MET in cancers, a pure anti-MET therapeutic has not yet received market approval. The failure of two recently concluded phase III trials point to a major weakness in biomarker strategies to identify patients who will benefit most from MET therapies. The capability to interrogate oncogenic mutations in MET via circulating tumor DNA (ctDNA) provides an important advancement in identification and stratification of patients for MET therapy. However, a wide range in type and frequency of these mutations suggest there is a need to carefully link these mutations to MET dysregulation, at least in proof-of-concept studies. In this review, we elaborate how we can utilize recently developed and validated pharmacodynamic biomarkers of MET not only to show target engagement, but more importantly to quantitatively measure MET dysregulation in tumor tissues. The MET assay endpoints provide evidence of both canonical and non-canonical MET signaling, can be used as “effect markers” to define biologically effective doses (BEDs) for molecularly targeted drugs, confirm mechanism-of-action in testing combination of drugs, and establish whether a diagnostic test is reporting MET dysregulation. We have established standard operating procedures for tumor biopsy collections to control pre-analytical variables that have produced valid results in proof-of-concept studies. The reagents and procedures are made available to the research community for potential implementation on multiple platforms such as ELISA, quantitative immunofluorescence assay (qIFA), and immuno-MRM assays. PMID:28164088

  20. HGF-MET in cancer progression and biomarker discovery.

    PubMed

    Matsumoto, Kunio; Umitsu, Masataka; De Silva, Dinuka M; Roy, Arpita; Bottaro, Donald P

    2017-01-08

    Signaling driven by hepatocyte growth factor (HGF) and MET receptor facilitates conspicuous biological responses such as epithelial cell migration, 3-D morphogenesis, and survival. The dynamic migration and promotion of cell survival induced by MET activation are bases respectively for invasion-metastasis and resistance against targeted drugs in cancers. Recent studies indicated that MET in tumor-derived exosomes facilitates metastatic niche formation and metastasis in malignant melanoma. In lung cancer, gene amplification-induced MET activation and ligand-dependent MET activation in autocrine/paracrine manner are causes for resistance to EGF receptor tyrosine kinase inhibitors and ALK inhibitors. HGF secreted in the tumor microenvironment contributes to the innate and acquired resistance to RAF inhibitors. Changes in serum/plasma HGF, soluble MET, and phosphor-MET have been confirmed to be associated with disease progression, metastasis, therapy response, and survival. Higher serum/plasma HGF levels are associated with therapy resistance and/or metastasis, while lower HGF levels are associated with progression-free survival and overall survival after treatment with targeted drugs in lung cancer, gastric cancer, colon cancer, and malignant melanoma. Urinary soluble MET levels in patients with bladder cancer are higher than those in patients without bladder cancer and associated with disease progression. Some of the multi-kinase inhibitors that target MET have received regulatory approval, whereas none of the selective HGF-MET inhibitors have shown efficacy in phase III clinical trials. Validation of the HGF-MET pathway as a critical driver in cancer development/progression and utilization of appropriate biomarkers are key to development and approval of HGF-MET inhibitors for clinical use. This article is protected by copyright. All rights reserved.

  1. Mars MetNet Mission Pressure and Humidity Devices

    NASA Astrophysics Data System (ADS)

    Haukka, H.; Harri, A.-M.; Schmidt, W.; Genzer, M.; Polkko, J.; Kemppinen, O.; Leinonen, J.

    2012-09-01

    A new kind of planetary exploration mission for Mars is being developed in collaboration between the Finnish Meteorological Institute (FMI), Lavochkin Association (LA), Space Research Institute (IKI) and Institutio Nacional de Tecnica Aerospacial (INTA). The Mars MetNet mission [1] is based on a new semi-hard landing vehicle called MetNet Lander (MNL). MetBaro and MetHumi are part of the scientific payload of the MNL. Main scientific goal of both devices is to measure the meteorological phenomena (pressure and humidity) of the Martian atmosphere and complement the previous Mars mission atmospheric measurements (Viking and Phoenix) for better understanding of the Martian atmospheric conditions.

  2. Hilltop supernatural inflation and SUSY unified models

    NASA Astrophysics Data System (ADS)

    Kohri, Kazunori; Lim, C. S.; Lin, Chia-Min; Mimura, Yukihiro

    2014-01-01

    In this paper, we consider high scale (100TeV) supersymmetry (SUSY) breaking and realize the idea of hilltop supernatural inflation in concrete particle physics models based on flipped-SU(5)and Pati-Salam models in the framework of supersymmetric grand unified theories (SUSY GUTs). The inflaton can be a flat direction including right-handed sneutrino and the waterfall field is a GUT Higgs. The spectral index is ns = 0.96 which fits very well with recent data by PLANCK satellite. There is no both thermal and non-thermal gravitino problems. Non-thermal leptogenesis can be resulted from the decay of right-handed sneutrino which plays (part of) the role of inflaton.

  3. Unified theory of nonlinear electrodynamics and gravity

    SciTech Connect

    Torres-Gomez, Alexander; Krasnov, Kirill; Scarinci, Carlos

    2011-01-15

    We describe a class of unified theories of electromagnetism and gravity. The Lagrangian is of the BF type, with a potential for the B field, the gauge group is U(2) (complexified). Given a choice of the potential function the theory is a deformation of (complex) general relativity and electromagnetism, and describes just two propagating polarizations of the graviton and two of the photon. When gravity is switched off the theory becomes the usual nonlinear electrodynamics with a general structure function. The Einstein-Maxwell theory can be recovered by sending some of the parameters of the defining potential to zero, but for any generic choice of the potential the theory is indistinguishable from Einstein-Maxwell at low energies. A real theory is obtained by imposing suitable reality conditions. We also study the spherically-symmetric solution and show how the usual Reissner-Nordstrom solution is recovered.

  4. Unified Ultrasonic/Eddy-Current Data Acquisition

    NASA Technical Reports Server (NTRS)

    Chern, E. James; Butler, David W.

    1993-01-01

    Imaging station for detecting cracks and flaws in solid materials developed combining both ultrasonic C-scan and eddy-current imaging. Incorporation of both techniques into one system eliminates duplication of computers and of mechanical scanners; unifies acquisition, processing, and storage of data; reduces setup time for repetitious ultrasonic and eddy-current scans; and increases efficiency of system. Same mechanical scanner used to maneuver either ultrasonic or eddy-current probe over specimen and acquire point-by-point data. For ultrasonic scanning, probe linked to ultrasonic pulser/receiver circuit card, while, for eddy-current imaging, probe linked to impedance-analyzer circuit card. Both ultrasonic and eddy-current imaging subsystems share same desktop-computer controller, containing dedicated plug-in circuit boards for each.

  5. Economic analysis of the unified heliostat array

    SciTech Connect

    Not Available

    1980-11-07

    The Unified Heliostat Array (UHA) is comprised of conventional two-axis heliostats mounted on a terraced south-facing wall of a single structure. The arrangement of heliostats on the array is chosen to eliminate or control the degree of inter-heliostat shading and blocking. The UHA was investifated as to cost and optical performance. Two heliostats, the Veda Industrial Heliostat (VIH) and the Repowering Heliostat were investigated in conjunction with the UHA. The UHA was found to be a viable candidate for solar thermal central receiver applications. The UHA-VIH combination was shown to provide very high flux densities and to be suitable for high temperature applications in the 1000/sup 0/K to 2000/sup 0/K range. These temperatures were shown to be achievable even with very small (1 MWt) collector fields.

  6. UniPOPS: Unified data reduction suite

    NASA Astrophysics Data System (ADS)

    Maddalena, Ronald J.; Garwood, Robert W.; Salter, Christopher J.; Stobie, Elizabeth B.; Cram, Thomas R.; Morgan, Lorrie; Vance, Bob; Hudson, Jerome

    2015-03-01

    UniPOPS, a suite of programs and utilities developed at the National Radio Astronomy Observatory (NRAO), reduced data from the observatory's single-dish telescopes: the Tucson 12-m, the Green Bank 140-ft, and archived data from the Green Bank 300-ft. The primary reduction programs, 'line' (for spectral-line reduction) and 'condar' (for continuum reduction), used the People-Oriented Parsing Service (POPS) as the command line interpreter. UniPOPS unified previous analysis packages and provided new capabilities; development of UniPOPS continued within the NRAO until 2004 when the 12-m was turned over to the Arizona Radio Observatory (ARO). The submitted code is version 3.5 from 2004, the last supported by the NRAO.

  7. On the History of Unified Field Theories

    NASA Astrophysics Data System (ADS)

    Goenner, Hubert F. M.

    2004-02-01

    This article is intended to give a review of the history of the classical aspects of unified field theories in the 20th century. It includes brief technical descriptions of the theories suggested, short biographical notes concerning the scientists involved, and an extensive bibliography. The present first installment covers the time span between 1914 and 1933, i.e., when Einstein was living and working in Berlin — with occasional digressions into other periods. Thus, the main theme is the unification of the electromagnetic and gravitational fields augmented by short-lived attempts to include the matter field described by Schrödinger's or Dirac's equations. While my focus lies on the conceptual development of the field, by also paying attention to the interaction of various schools of mathematicians with the research done by physicists, some prosopocraphical remarks are included.

  8. Neutrino dark energy in grand unified theories

    SciTech Connect

    Bhatt, Jitesh R.; Sarkar, Utpal; Singh, Santosh K.; Gu, P.-H.

    2009-10-01

    We studied a left-right symmetric model that can accommodate the neutrino dark energy ({nu}DE) proposal. The type-III seesaw mechanism is implemented to give masses to the neutrinos. After explaining the model, we study the consistency of the model by minimizing the scalar potential and obtaining the conditions for the required vacuum expectation values of the different scalar fields. This model is then embedded in an SO(10) grand unified theory and the allowed symmetry breaking scales are determined by the condition of the gauge coupling unification. Although SU(2){sub R} breaking is required to be high, its Abelian subgroup U(1){sub R} is broken in the TeV range, which can then give the required neutrino masses and predicts new gauge bosons that could be detected at LHC. The neutrino masses are studied in detail in this model, which shows that at least 3 singlet fermions are required.

  9. Unifying Gate Synthesis and Magic State Distillation

    NASA Astrophysics Data System (ADS)

    Campbell, Earl T.; Howard, Mark

    2017-02-01

    The leading paradigm for performing a computation on quantum memories can be encapsulated as distill-then-synthesize. Initially, one performs several rounds of distillation to create high-fidelity magic states that provide one good T gate, an essential quantum logic gate. Subsequently, gate synthesis intersperses many T gates with Clifford gates to realize a desired circuit. We introduce a unified framework that implements one round of distillation and multiquibit gate synthesis in a single step. Typically, our method uses the same number of T gates as conventional synthesis but with the added benefit of quadratic error suppression. Because of this, one less round of magic state distillation needs to be performed, leading to significant resource savings.

  10. A Unified Theory of Trust and Collaboration

    NASA Astrophysics Data System (ADS)

    Cai, Guoray; Squicciarini, Anna

    We consider a type of applications where collaboration and trust are tightly coupled with the need to protect sensitive information. Existing trust management technologies have been limited to offering generic mechanisms for enforcing access control policies based on exchanged credentials, and rarely deal with the situated meaning of trust in a specific collaborative context. Towards trust management for highly dynamic and collaborative activities, this paper describes a theory of trust intention and semantics that makes explicit connections between collaborative activities and trust. The model supports inferring trust state based on knowledge about state of collaborative activity. It is the first step towards a unified approach for computer-mediated trust communication in the context of collaborative work.

  11. Unified theories and the early universe

    NASA Astrophysics Data System (ADS)

    Nanopoulos, D. V.

    1988-05-01

    The interface between particle physics and cosmology, particularly inflationary cosmology, is reviewed. Grand unified theories (GUT) and Big Bang Cosmology (BBC) are discussed. The standard model of particle physics was extended to GUTs, super GUTs or possibly superstring theories, while the standard BBC was extended to contain the inflationary era. Inflation predicts omega = 1 and adiabatic, scale invariant energy density perturbations, which will be tested in experiment. Present experimental values are much smaller than one, but it seems that mass is being missed (better light), and there is dark matter that may close the Universe. Particle theory provides a list of candidates, e.g., photino, massive neutrino, axion, for dark matter and particle experimenters are building dark matter detectors to test these ideas. Developments in galaxy formation and observational developments on the large structure of the Universe, may put under severe test the ideas of scale-invariant energy density perturbations.

  12. Neutrino dark energy in grand unified theories

    NASA Astrophysics Data System (ADS)

    Bhatt, Jitesh R.; Gu, Pei-Hong; Sarkar, Utpal; Singh, Santosh K.

    2009-10-01

    We studied a left-right symmetric model that can accommodate the neutrino dark energy (νDE) proposal. The type-III seesaw mechanism is implemented to give masses to the neutrinos. After explaining the model, we study the consistency of the model by minimizing the scalar potential and obtaining the conditions for the required vacuum expectation values of the different scalar fields. This model is then embedded in an SO(10) grand unified theory and the allowed symmetry breaking scales are determined by the condition of the gauge coupling unification. Although SU(2)R breaking is required to be high, its Abelian subgroup U(1)R is broken in the TeV range, which can then give the required neutrino masses and predicts new gauge bosons that could be detected at LHC. The neutrino masses are studied in detail in this model, which shows that at least 3 singlet fermions are required.

  13. A unified approach to the Darwin approximation

    SciTech Connect

    Krause, Todd B.; Apte, A.; Morrison, P. J.

    2007-10-15

    There are two basic approaches to the Darwin approximation. The first involves solving the Maxwell equations in Coulomb gauge and then approximating the vector potential to remove retardation effects. The second approach approximates the Coulomb gauge equations themselves, then solves these exactly for the vector potential. There is no a priori reason that these should result in the same approximation. Here, the equivalence of these two approaches is investigated and a unified framework is provided in which to view the Darwin approximation. Darwin's original treatment is variational in nature, but subsequent applications of his ideas in the context of Vlasov's theory are not. We present here action principles for the Darwin approximation in the Vlasov context, and this serves as a consistency check on the use of the approximation in this setting.

  14. Hilltop supernatural inflation and SUSY unified models

    SciTech Connect

    Kohri, Kazunori; Lim, C.S.; Lin, Chia-Min; Mimura, Yukihiro E-mail: lim@lab.twcu.ac.jp E-mail: mimura@hep1.phys.ntu.edu.tw

    2014-01-01

    In this paper, we consider high scale (100TeV) supersymmetry (SUSY) breaking and realize the idea of hilltop supernatural inflation in concrete particle physics models based on flipped-SU(5)and Pati-Salam models in the framework of supersymmetric grand unified theories (SUSY GUTs). The inflaton can be a flat direction including right-handed sneutrino and the waterfall field is a GUT Higgs. The spectral index is n{sub s} = 0.96 which fits very well with recent data by PLANCK satellite. There is no both thermal and non-thermal gravitino problems. Non-thermal leptogenesis can be resulted from the decay of right-handed sneutrino which plays (part of) the role of inflaton.

  15. Unifying family A GPCR theories of activation.

    PubMed

    Tehan, Benjamin G; Bortolato, Andrea; Blaney, Frank E; Weir, Malcolm P; Mason, Jonathan S

    2014-07-01

    Several new pairs of active and inactive GPCR structures have recently been solved enabling detailed structural insight into the activation process, not only of rhodopsin but now also of the β2 adrenergic, M2 muscarinic and adenosine A2A receptors. Combined with structural analyses they have enabled us to examine the different recent theories proposed for GPCR activation and show that they are all indeed parts of the same process, and are intrinsically related through their effect on the central hydrophobic core of GPCRs. This new unifying general process of activation is consistent with the identification of known constitutively active mutants and an in-depth conservational analysis of significant residues implicated in the process. Copyright © 2014 Elsevier Inc. All rights reserved.

  16. Pediatric office emergencies.

    PubMed

    Klig, Jean E; O'Malley, Patricia J

    2007-10-01

    An emergency in the office setting can be problematic without adequate staff, support, tools, and protocols. Though many emergencies are not immediately life-threatening, one risks the 'worst case scenario' occurring if not adequately prepared. Pediatric patients are prone to respiratory distress and compromise in many emergencies, and can rapidly decompensate without adequate support. A review of the history of emergency medical services for children and the framework for office emergency preparedness offers insight into current challenges for primary care providers. Research has demonstrated that many primary care offices and clinics are ill prepared to handle common pediatric emergencies. Reliance on the Emergency Medical Services system is insufficient to assure optimal outcomes, especially given variations in the equipment, training, and experience of Emergency Medical Services providers in the care of children, and in remote areas where access may be delayed. Preparation and practice for office emergencies through 'mock code' exercises can increase practitioner confidence and reduce anxiety to perform life-saving care. Better outcomes for office emergencies can result from staff training, availability of appropriate equipment and medications, maintenance of skills via formal and informal practice, and pathways for expeditious transfer to a definitive care facility.

  17. Supporting Teachers, Principals--and Students--through Unified Discipline.

    ERIC Educational Resources Information Center

    Algozzine, Bob; Audette, Bob; Ellis, Edward; Marr, Mary Beth; White, Richard

    2000-01-01

    This article profiles Unified Discipline, a schoolwide systemic model of discipline that incorporates factors associated with best practices in teaching behavior and improving discipline. The four components of the program are described and include unified attitudes, expectations, correction, and team roles. Implications for practice are…

  18. Unified Science Approach K-12, Proficiency Levels 1-6.

    ERIC Educational Resources Information Center

    Oickle, Eileen M., Ed.

    Presented are first-revision materials of the K-12 unified science program implemented in the public schools of Anne Arundel County, Maryland. Detailed descriptions are given of the roles of students and teachers, purposes of bibliography, major concepts in unified science, processes of inquiry, scheme and model for scientific literacy, and…

  19. Educating All Students Together: How School Leaders Create Unified Systems.

    ERIC Educational Resources Information Center

    Burrello, Leonard C.; Lashley, Carl; Beatty, Edith E.

    This book established a plan for creating a truly integrated educational system, one that unifies the separate and parallel systems of special and general education. Chapter 1, "Students at the Margins," explores the dual tragedy of discouraged and disinterested students and presents eight essential questions guiding a unified system of…

  20. 24 CFR 578.41 - Unified Funding Agency costs.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 3 2014-04-01 2013-04-01 true Unified Funding Agency costs. 578.41 Section 578.41 Housing and Urban Development Regulations Relating to Housing and Urban Development... § 578.41 Unified Funding Agency costs. (a) In general. UFAs may use up to 3 percent of their FPRN, or a...

  1. Unified Science Approach K-12, Proficiency Levels 7-12.

    ERIC Educational Resources Information Center

    Oickle, Eileen M., Ed.

    Presented is the second part of the K-12 unified science materials used in the public schools of Anne Arundel County, Maryland. Detailed descriptions are made of the roles of students and teachers, purposes of the bibliography, major concepts in unified science, processes of inquiry, a scheme and model for scientific literacy, and program…

  2. Response to MET inhibitors in patients with stage IV lung adenocarcinomas harboring MET mutations causing exon 14 skipping

    PubMed Central

    Paik, Paul K.; Drilon, Alexander; Fan, Pang-Dian; Yu, Helena; Rekhtman, Natasha; Ginsberg, Michelle S.; Borsu, Laetitia; Schultz, Nikolaus; Berger, Michael F.; Rudin, Charles M.; Ladanyi, Marc

    2015-01-01

    Mutations in the MET exon 14 RNA splice acceptor and donor sites, which lead to exon skipping, deletion of the juxtamembrane domain containing the Cbl E3-ubiquitin ligase binding site, and decreased turnover of the resultant aberrant MET protein, were previously reported to be oncogenic in preclinical models. We now report responses to the MET inhibitors crizotinib and cabozantinib in four patients with stage IV lung adenocarcinomas harboring mutations leading to MET exon 14 skipping, highlighting a new therapeutic strategy for the 4% of lung adenocarcinoma patients whose tumors harbor this previously underappreciated genetic alteration. PMID:25971939

  3. Reversal of c-MET-mediated Resistance to Cytotoxic Anticancer Drugs by a Novel c-MET Inhibitor TAS-115.

    PubMed

    Kunii, Eiji; Ozasa, Hiroaki; Oguri, Tetsuya; Maeno, Ken; Fukuda, Satoshi; Uemura, Takehiro; Takakuwa, Osamu; Ohkubo, Hirotsugu; Takemura, Masaya; Niimi, Akio

    2015-10-01

    The cellular N-methyl-N'-nitroso-guanidine human osteosarcoma transforming gene (c-MET) protein is the receptor tyrosine kinase for hepatocyte growth factor. We recently found that c-MET protein expression and activation were enhanced in the majority of small cell lung cancer cell lines with cytotoxic anticancer drug resistance, and that down-regulation of c-MET reduced resistance to these drugs. Expression of c-MET was studied in three non-small cell lung cancer (NSCLC) cell lines, including six resistant cell strains to cytotoxic anticancer drugs. To assess the effect of c-MET activation on drug resistance, we studied drug sensitivity in the presence of a novel c-MET inhibitor TAS-115. c-MET expression and activation are also enhanced in some cytotoxic anticancer drug-resistant NSCLC cell lines, and inhibition of c-MET activation by TAS-115 reduced resistance of these cell lines to anticancer drugs. The mechanism of cellular resistance to anticancer drugs via hepatocyte growth factor/c-MET signal activation is not restricted to small cell lung cancer cell lines, and TAS-115 might be able to reverse the drug resistance of these cancer cells. Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

  4. Office of Inspector General audit report on small disadvantaged business program at the Chicago Operations Office

    SciTech Connect

    1999-01-01

    The Office of Inspector General performed audits of the Small Disadvantaged Business Program at five management and operating contractors in FY 1994. The audits disclosed that none of the contractors fully met the intent of the Act and implementing regulations. The contractors awarded some subcontracts to firms of questionable program eligibility. Also, two of the contractors concentrated awards among a limited number of small disadvantaged businesses, and used procurement practices that precluded opportunities for many small disadvantaged businesses to participate. The objective of this audit was to determine whether Chicago was providing the maximum practicable opportunity for small disadvantaged businesses to participate in contract awards.

  5. Unifying neutron stars getting to GUNS

    NASA Astrophysics Data System (ADS)

    Igoshev, A. P.; Popov, S. B.; Turolla, R.

    2014-03-01

    The variety of the observational appearance of young isolated neutron stars must find an explanation in the framework of some unifying approach. Nowadays it is believed that such scenario must include magnetic field decay, the possibility of magnetic field emergence on a time scale of ≲ 104-105 yr, significant contribution of non-dipolar fields, and appropriate initial parameter distributions. We present our results on the initial spin period distribution, and suggest that inconsistencies between distributions derived by different methods for samples with different average ages can uncover field decay or/and emerging field. We describe a new method to probe the magnetic field decay in normal pulsars. The method is a modified pulsar current approach, where we study pulsar flow along the line of increasing characteristic age for constant field. Our calculations, performed with this method, can be fitted with an exponential decay for ages in the range of 8× 104-3.5 × 105 yr with a time scale of ˜ 5 × 105 yr. We discuss several issues related to the unifying scenario. At first, we note that the dichotomy, among local thermally emitting neutron stars, between normal pulsars and the Magnificent Seven remains unexplained. Then we discuss the role of high-mass X-ray binaries in the unification of neutron star evolution. We note, that such systems allow to check evolutionary effects on a time scale longer than what can be probed with normal pulsars alone. We conclude with a brief discussion of the importance of discovering old neutron stars accreting from the interstellar medium.

  6. [Prenatal care within Brazil's Unified Health System].

    PubMed

    Costa, Ana Maria; Guilhem, Dirce; Walter, Maria Inêz Machado Telles

    2005-10-01

    To assess antenatal care in health care units, so as to obtain a baseline for future evaluation studies. A self-applied inquiry was conducted among municipal health managers within a probabilistic stratified random sample of 627 municipalities which, through expansion technique, extended the analysis to 5,507 municipalities. Data was collected from October 2003 to April 2004. The survey appraised information about the priority granted by the managers to each modality of care, as well as data concerning characteristics of the assistance provided and the declared estimate of the demand being covered. The Chi-square test and Student's t-test were performed in order to verify independence among the qualitative variables and mean differences, respectively. Almost half (43.8%; n=2,317) of the municipalities did not attend gestational risk; 81% (n=4,277) and 30.1% (n=1,592) reported that they attend over 75% of the demand for low and high risk antenatal respectively; 30.1% (n=1,592) attend over 75% of the demand for high risk care. Care for low risk (chi2=282,080; P<0.001 n=4,277) and for high risk pregnancies (chi2=267.924; P<0.001 n=5,280) were associated to geographic region, municipality's size and management modality within the Unified Health System. The guarantee of vacancy for labour and birth was also associated to management modality. There were gaps related to the provision and the quality of antenatal care within the Unified Health System. Municipal based health care extends the provision of antenatal care, but there are inequalities among regions and among municipalities according to demographic size.

  7. Finite unified theories and their predicitions

    NASA Astrophysics Data System (ADS)

    Heinemeyer, S.; Mondragón, M.; Zoupanos, G.

    2013-03-01

    All-loop Finite Unified Theories (FUTs) are very interesting N = 1 supersymmetric Grand Unified Theories (GUTs) realising an old field theory dream, and moreover have a remarkable predictive power due to the required reduction of couplings. The reduction of the dimensionless couplings in N = 1 GUTs is achieved by searching for renormalization group invariant (RGI) relations among them holding beyond the unification scale. Finiteness results from the fact that there exist RGI relations among dimensional couplings that guarantee the vanishing of all beta-functions in certain N = 1 GUTs even to all orders. Additional developments in the soft supersymmetry breaking sector of N = 1 GUTs and FUTs lead to exact RGI relations, i.e. reduction of couplings, in this dimensionful sector of the theory, too. Based on the above theoretical framework phenomenologically consistent FUTs have been constructed. Here we review two FUT models based on the SU(5) gauge group. Confronting their predictions with the top and bottom quark masses and other experimental constraints a light Higgs-boson mass in the range M H ˜ 121-126 GeV has been predicted, in striking agreement with the recent experimental results from ATLAS and CMS. Furthermore naturally a relatively heavy s-spectrum emerged with coloured supersymmetric particles above ˜1.5 TeV in agreement with the non-observation of those particles at the LHC. Restricting further the parameter space of the best version of the SU(5) FUT according to the reported accuracy of the Higgs boson mass and B-physics observables we find predictions for the rest of the Higgs masses and the s-spectrum.

  8. Unified Action: A Bridge Too Far?

    DTIC Science & Technology

    2008-04-23

    13 Subordinate to Eisenhower were three British officers, Admiral Sir Bertram H. Ramsay , Air Chief Marshal Sir Trafford Mallory, and General Sir ...component commander, commanded Seventh Fleet which was tasked to support the amphibious landings.17 Admiral William F. “Bull” Halsey Jr., the

  9. Success, but Slowly, as Met School Redefines Learning

    ERIC Educational Resources Information Center

    Pearson, George

    2012-01-01

    Seven Oaks Met School, the only high school in Canada that is part of the U.S.-based Big Picture Learning network of innovative schools, graduated its first class this spring. Internships with businesses and institutions in the community are a core element of the Met School experience. Students report on their internship experience, as well as on…

  10. Success, but Slowly, as Met School Redefines Learning

    ERIC Educational Resources Information Center

    Pearson, George

    2012-01-01

    Seven Oaks Met School, the only high school in Canada that is part of the U.S.-based Big Picture Learning network of innovative schools, graduated its first class this spring. Internships with businesses and institutions in the community are a core element of the Met School experience. Students report on their internship experience, as well as on…

  11. Clinical Data Element Ontology for Unified Indexing and Retrieval of Data Elements across Multiple Metadata Registries.

    PubMed

    Jeong, Senator; Kim, Hye Hyeon; Park, Yu Rang; Kim, Ju Han

    2014-10-01

    Classification of data elements (DEs), which is used in clinical documents is challenging, even in across ISO/IEC 11179 compliant clinical metadata registries (MDRs) due to no existence of reliable standard for identifying DEs. We suggest the Clinical Data Element Ontology (CDEO) for unified indexing and retrieval of DEs across MDRs. The CDEO was developed through harmonization of existing clinical document models and empirical analysis of MDRs. For specific classification as using data element concept (DEC), The Simple Knowledge Organization System was chosen to represent and organize the DECs. Six basic requirements also were set that the CDEO must meet, including indexing target to be a DEC, organizing DECs using their semantic relationships. For evaluation of the CDEO, three indexers mapped 400 DECs to more than 1 CDEO term in order to determine whether the CDEO produces a consistent index to a given DEC. The level of agreement among the indexers was determined by calculating the intraclass correlation coefficient (ICC). We developed CDEO with 578 concepts. Through two application use-case scenarios, usability of the CDEO is evaluated and it fully met all of the considered requirements. The ICC among the three indexers was estimated to be 0.59 (95% confidence interval, 0.52-0.66). The CDEO organizes DECs originating from different MDRs into a single unified conceptual structure. It enables highly selective search and retrieval of relevant DEs from multiple MDRs for clinical documentation and clinical research data aggregation.

  12. United States Army Officer Professional Development: Black Officers’ Perspectives.

    DTIC Science & Technology

    1997-04-01

    majority contemporaries. These statistics pose interesting questions about black officer professional development and career progress. How has the Army...fared with the professional development of blacks within the officer corps? What is the perception of black officers currently serving within the...institution regarding the Army’s efforts to provide professional development for black officers? Do systemic prejudices toward blacks in the officer corps

  13. 7 CFR 2.4 - General officers.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Civil Rights; the General Counsel; the Inspector General; the Chief Financial Officer; the Chief Information Officer; the Judicial Officer; the Director, Office of Budget and Program Analysis; the...

  14. School Resources Officers. Briefing Paper

    ERIC Educational Resources Information Center

    Arkansas Safe Schools Initiative Division, 2001

    2001-01-01

    Most school resource officers (SROs) are employees of municipal or county police agencies who are permanently assigned to one or more schools. Known also as "School Safety Officers," "Community Outreach Officers," and "School Liaison Officers," SROs are not synonymous with school security or school police departments because of their multifaceted…

  15. Impact of MET targeting on tumor-associated angiogenesis and growth of MET mutations-driven models of liver cancer

    PubMed Central

    Keogh, Adrian; Glück, Astrid A.; Aebersold, Daniel M.; Dufour, Jean-François; Zimmer, Yitzhak

    2015-01-01

    Deregulated expression of the MET receptor tyrosine kinase has been reported in up to 50% of patients with hepatocellular carcinoma, the most abundant form of liver cancers, and is associated with decreased survival. Consequently, MET is considered as a molecular target in this malignancy, whose progression is highly dependent on extensive angiogenesis. Here we studied the impact of MET small molecule inhibitors on angiogenesis-associated parameters and growth of xenograft liver models consisting of cells expressing MET-mutated variants M1268T and Y1248H, which exhibit constitutive kinase activity. We demonstrate that MET mutations expression is associated with significantly increased production of vascular endothelial growth factor, which is blocked by MET targeting only in cells expressing the M1268T inhibitor-sensitive but not in the Y1248H inhibitor-resistant variant. Decrease in vascular endothelial growth factor production is also associated with reduction of tyrosine phopshorylation of the vascular endothelial growth factor receptor 2 expressed on primary liver sinusoidal endothelial cells and with inhibition of vessel formation. Furthermore, MET inhibition demonstrated an efficient anti-tumor activity and considerable reduction in microvessel density only against the M1268T-derived intrahepatic tumors. Collectively, our data support the role of targeting MET-associated angiogenesis as a major biological determinant for liver tumor growth control. PMID:26413215

  16. Office of Cancer Genomics |

    Cancer.gov

    The mission of the NCI’s Office of Cancer Genomics (OCG) is to enhance the understanding of the molecular mechanisms of cancer, advance and accelerate genomics science and technology development, and efficiently translate the genomics data to improve cancer research, prevention, early detection, diagnosis and treatment.

  17. Officer Computer Utilization Report

    DTIC Science & Technology

    1992-03-01

    SIGNIFV11ANT @ YES PREVIOUSLY 0 00" for 0 months.)0 EXRML INFCN DYES BO0TH CURRENTLY AND PREVIOUSLY __________ -5- s- -js ! EC O : PESO A A JO BA K RO N INO...U SECO F: M This section asks questions about issues related to microcomputers, to include office automation and Information management. A

  18. Financing medical office buildings.

    PubMed

    Blake, J W

    1995-01-01

    This article discusses financing medical office buildings. In particular, financing and ownership options from a not-for-profit health care system perspective are reviewed, including use of tax-exempt debt, taxable debt, limited partnerships, sale, and real estate investment trusts (REITs).

  19. Office of the Ombudsman.

    ERIC Educational Resources Information Center

    Office of Federal Student Aid (ED), Washington, DC.

    This pamphlet describes the Federal Student Aid Ombudsman, an impartial resource to help customers resolve student loan concerns when other approaches fail. The ombudsman helps resolve discrepancies in loan balances and payments, and helps customers understand interest and collection charges. The office helps resolve issues related to income tax…

  20. Impressions of Psychotherapists' Offices

    ERIC Educational Resources Information Center

    Nasar, Jack L.; Devlin, Ann Sloan

    2011-01-01

    For counseling settings, research suggests that softness, personalization, and order might affect the experience and the perceived expertness, trustworthiness, and social attractiveness of the therapist. This article discusses exploratory studies on college students' perception of the counseling office environment and whether the likely client…

  1. The Mindful Development Officer

    ERIC Educational Resources Information Center

    Taft, Deb

    2012-01-01

    Delivering on a commitment to diversity in schools, colleges, and universities is a living, breathing endeavor for many members of the advancement community. While a diversity leadership agenda is set clearly from the top, advancement officers can and must play a critical role in this arena. Effective development and alumni leaders are uniquely…

  2. An Admissions Officer's Credentials

    ERIC Educational Resources Information Center

    Chronicle of Higher Education, 2007

    2007-01-01

    Marilee Jones has resigned as a dean of admissions at the Massachusetts Institute of Technology after admitting that she had misrepresented her academic degrees when first applying to work at the university in 1979. As one of the nation's most prominent admissions officers--and a leader in the movement to make the application process less…

  3. The Mindful Development Officer

    ERIC Educational Resources Information Center

    Taft, Deb

    2012-01-01

    Delivering on a commitment to diversity in schools, colleges, and universities is a living, breathing endeavor for many members of the advancement community. While a diversity leadership agenda is set clearly from the top, advancement officers can and must play a critical role in this arena. Effective development and alumni leaders are uniquely…

  4. Teamwork Improves Office Climate.

    ERIC Educational Resources Information Center

    Winck, Susan K.

    1993-01-01

    The Smeal College of Business Administration at the Pennsylvania State University selected its advising center as the pilot unit for a continuous quality improvement project using Total Quality Management principles. It was found that a quality improvement culture evolves when team practices are carried into the everyday office environment.…

  5. Trends in Office Automation.

    ERIC Educational Resources Information Center

    School Business Affairs, 1985

    1985-01-01

    Reports the major findings of a national survey of office professionals conducted by Honeywell Incorporated. When asked how they would spend $10,000 to increase their personal productivity, the majority of workers surveyed said they would buy a computer, software, or word processor. (MD)

  6. Office of Cancer Genomics |

    Cancer.gov

    The mission of the NCI’s Office of Cancer Genomics (OCG) is to enhance the understanding of the molecular mechanisms of cancer, advance and accelerate genomics science and technology development, and efficiently translate the genomics data to improve cancer research, prevention, early detection, diagnosis and treatment.

  7. Front Range Branch Officers

    NASA Astrophysics Data System (ADS)

    The Front Range Branch of AGU has installed officers for 1990: Ray Noble, National Center for Atmospheric Research, chair; Sherry Oaks, U.S. Geological Survey, chair-elect; Howard Garcia, NOAA, treasurer; Catharine Skokan, Colorado School of Mines, secretary. JoAnn Joselyn of NOAA is past chair. Members at large are Wallace Campbell, NOAA; William Neff, USGS; and Stephen Schneider, NCAR.

  8. Troubleshooting in Medical Offices

    PubMed Central

    Gillespie, A. B.

    1977-01-01

    Physicians usually go into practice with little or no instruction in how to manage their business affairs or organize their offices. Many questions, such as where to practice, whether to join a group and whether to incorporate, must be answered. Several sources of help are available, but nothing substitutes for knowledge of the basic principles outlined in this article.

  9. Impressions of Psychotherapists' Offices

    ERIC Educational Resources Information Center

    Nasar, Jack L.; Devlin, Ann Sloan

    2011-01-01

    For counseling settings, research suggests that softness, personalization, and order might affect the experience and the perceived expertness, trustworthiness, and social attractiveness of the therapist. This article discusses exploratory studies on college students' perception of the counseling office environment and whether the likely client…

  10. Reception and office organisation.

    PubMed

    Wilkinson, M D

    1989-05-20

    The reception area is central to efficient administrative procedures and is the embodiment of the style of a practice as regularly seen by every patient. Planning a reception office is not difficult but it should be done carefully to ensure that it is efficient and cost effective. In the second of his articles on practice management, Michael Wilkinson looks at the essentials.

  11. Cooperative Office Education Manual.

    ERIC Educational Resources Information Center

    Clemson Univ., SC. Vocational Education Media Center.

    This manual, intended for inexperienced and experienced coordinators, school administrators, and guidance personnel, is designed to provide practical suggestions for initiating, developing, operating, coordinating, improving, and evaluating cooperative office education programs. Major content is presented primarily in outline form under the…

  12. Patterns and Predictors of Alcohol Use in Male and Female Urban Police Officers

    PubMed Central

    Ballenger, James F.; Best, Suzanne R.; Metzler, Thomas J.; Wasserman, David A.; Mohr, David C.; Liberman, Akiva; Delucchi, Kevin; Weiss, Daniel S.; Fagan, Jeffrey A.; Waldrop, Angela E.; Marmar, Charles R.

    2011-01-01

    In a large sample of urban police officers, 18.1% of males and 15.9% of females reported experiencing adverse consequences from alcohol use and 7.8 % of the sample met criteria for lifetime alcohol abuse or dependence. Female officers had patterns of alcohol use similar to male officers and substantially more than females in the general population. Critical incident exposure and PTSD symptoms were not associated with level of alcohol use. Greater psychiatric symptoms were related to adverse consequences from alcohol use. There was a noteworthy gender by work stress interaction: greater routine work stress related to lower current alcohol use in female officers. PMID:21175917

  13. The prevalence of metabolic syndrome among law enforcement officers who responded to the 9/11 World Trade Center attacks.

    PubMed

    Moline, Jacqueline M; McLaughlin, Mary Ann; Sawit, Simonette T; Maceda, Cynara; Croft, Lori B; Goldman, Martin E; Garcia, Mario J; Iyengar, Rupa L; Woodward, Mark

    2016-09-01

    Law enforcement officers (LEOs) experience high rates of cardiovascular events compared with the general US population. Metabolic syndrome (MetS) confers an increased risk of cardiovascular disease and all-cause mortality. Data regarding MetS among LEOs are limited. We sought to determine the prevalence of MetS and its associated risk factors as well as gender differences among LEOs who participated in the World Trade Center (WTC) Law Enforcement Cardiovascular Screening (LECS) Program from 2008 to 2010. We evaluated a total of 2,497 participants, 40 years and older, who responded to the 9/11 WTC attacks. The prevalence of MetS was 27%, with abdominal obesity and hypertension being the most frequently occurring risk factors. MetS and its risk factors were significantly higher among male compared to female LEOs, except for reduced HDL-cholesterol levels. MetS is a rising epidemic in the United States, and importantly, approximately one in four LEOs who worked at the WTC site after 9/11 are affected. Am. J. Ind. Med. 59:752-760, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  14. ASI/MET Within Color-Enhanced Panorama

    NASA Technical Reports Server (NTRS)

    1997-01-01

    This is a sub-section of the 'geometrically improved, color enhanced' version of the 360-degree panorama heretofore known as the 'Gallery Pan', the first contiguous, uniform panorama taken by the Imager for Mars Pathfinder (IMP) over the course of Sols 8, 9, and 10. Different regions were imaged at different times over the three Martian days to acquire consistent lighting and shadow conditions for all areas of the panorama.

    The IMP is a stereo imaging system that, in its fully deployed configuration, stands 1.8 meters above the Martian surface, and has a resolution of two millimeters at a range of two meters. In this geometrically improved version of the panorama, distortion due to a 2.5 degree tilt in the IMP camera mast has been removed, effectively flattening the horizon.

    The IMP has color capability provided by 24 selectable filters -- twelve filters per 'eye'. Its red, green, and blue filters were used to take this image. The color was digitally balanced according to the color transmittance capability of a high-resolution TV at the Jet Propulsion Laboratory (JPL), and is dependent on that device. In this color enhanced version of the panorama, detail in surface features are brought out via changes to saturation and intensity, holding the original hue constant. A threshold was applied to avoid changes to the sky.

    At the bottom of the image, two of the Lander petals are visible. At the extreme right of the image, the Atmospheric Structure Instrument and Meteorology package (ASI/MET) mast, with its three windsocks, is visible.

    Mars Pathfinder is the second in NASA's Discovery program of low-cost spacecraft with highly focused science goals. The Jet Propulsion Laboratory, Pasadena, CA, developed and manages the Mars Pathfinder mission for NASA's Office of Space Science, Washington, D.C. JPL is a division of the California Institute of Technology (Caltech). The IMP was developed by the University of Arizona Lunar and Planetary Laboratory under contract

  15. MET-EGFR dimerization in lung adenocarcinoma is dependent on EGFR mtations and altered by MET kinase inhibition

    PubMed Central

    Owen, William; Weitsman, Gregory; Fruhwirth, Gilbert; Dunn, Robert G.; Neat, Michael J.; McCaughan, Frank; Parker, Peter; Ng, Tony; Santis, George

    2017-01-01

    Advanced lung cancer has poor survival with few therapies. EGFR tyrosine kinase inhibitors (TKIs) have high response rates in patients with activating EGFR mutations, but acquired resistance is inevitable. Acquisition of the EGFR T790M mutation causes over 50% of resistance; MET amplification is also common. Preclinical data suggest synergy between MET and EGFR inhibitors. We hypothesized that EGFR-MET dimerization determines response to MET inhibition, depending on EGFR mutation status, independently of MET copy number. We tested this hypothesis by generating isogenic cell lines from NCI-H1975 cells, which co-express L858R and T790M EGFR mutations, namely H1975L858R/T790M (EGFR TKI resistant); H1975L858R (sensitized) and H1975WT (wild-type). We assessed cell proliferation in vitro and tumor growth/stroma formation in derived xenograft models in response to a MET TKI (SGX523) and correlated with EGFR-MET dimerization assessed by Förster Resonance Energy Transfer (FRET). SGX523 significantly reduced H1975L858R/T790M cell proliferation, xenograft tumor growth and decreased ERK phosphorylation. The same was not seen in H1975L858R or H1975WT cells. SGX523 only reduced stroma formation in H1975L858R. SGX523 reduced EGFR-MET dimerization in H1975L858R/T790M but induced dimer formation in H1975L858R with no effect in H1975WT. Our data suggests that MET inhibition by SGX523 and EGFR-MET heterodimerisation are determined by EGFR genotype. As tumor behaviour is modulated by this interaction, this could determine treatment efficacy. PMID:28141869

  16. A comparison of metabolic syndrome (MetS) risk factors in Filipino women and Filipino American women: a pilot study.

    PubMed

    Ancheta, Irma B; Battie, Cynthia A; Tuason, Teresa; Ancheta, Christine V

    2012-01-01

    Cardiovascular disease (CVD) is a significant cause of morbidity and mortality in women of Filipino ethnicity. The objective of our work was to determine if metabolic syndrome (MetS), a modifiable CVD risk factor, differs in women as a function of country of residency and to determine if, CVD prevention strategies need to differ for these groups of Filipino women. Data were collected in community-based health screenings for this cross-sectional study. PARTICIPANTS were recruited at places of worship in southeast United States (n=60) and Central Visayas, Philippines (n=56). Prevalence of MetS and its component factors as defined by the International Diabetes Federation criteria. The prevalence of MetS in Filipino women (FW) and Filipino American women (FAW) groups was similar (52% vs 55%, P=.08) although the prevalence of elevated waist circumference was greater for FAW (78% vs 59%, P=.03). Conversely, the percentage of FW women with risk-associated high-density lipoprotein (HDL) levels was higher than the FAW group (84% vs 42%, P<.001). Other MetS component factors (blood pressure, glucose and triglycerides) did not significantly differ between groups. Similar high rates of MetS were observed in Filipino women regardless of the country of residency although the FAW tended to have higher rates of central obesity while the FW tended to have higher rates of risk-associated HDL levels. Further research should examine the cause of these differences in order to develop better cardiovascular screening and intervention strategies.

  17. MET-EGFR dimerization in lung adenocarcinoma is dependent on EGFR mtations and altered by MET kinase inhibition.

    PubMed

    Ortiz-Zapater, Elena; Lee, Richard W; Owen, William; Weitsman, Gregory; Fruhwirth, Gilbert; Dunn, Robert G; Neat, Michael J; McCaughan, Frank; Parker, Peter; Ng, Tony; Santis, George

    2017-01-01

    Advanced lung cancer has poor survival with few therapies. EGFR tyrosine kinase inhibitors (TKIs) have high response rates in patients with activating EGFR mutations, but acquired resistance is inevitable. Acquisition of the EGFR T790M mutation causes over 50% of resistance; MET amplification is also common. Preclinical data suggest synergy between MET and EGFR inhibitors. We hypothesized that EGFR-MET dimerization determines response to MET inhibition, depending on EGFR mutation status, independently of MET copy number. We tested this hypothesis by generating isogenic cell lines from NCI-H1975 cells, which co-express L858R and T790M EGFR mutations, namely H1975L858R/T790M (EGFR TKI resistant); H1975L858R (sensitized) and H1975WT (wild-type). We assessed cell proliferation in vitro and tumor growth/stroma formation in derived xenograft models in response to a MET TKI (SGX523) and correlated with EGFR-MET dimerization assessed by Förster Resonance Energy Transfer (FRET). SGX523 significantly reduced H1975L858R/T790M cell proliferation, xenograft tumor growth and decreased ERK phosphorylation. The same was not seen in H1975L858R or H1975WT cells. SGX523 only reduced stroma formation in H1975L858R. SGX523 reduced EGFR-MET dimerization in H1975L858R/T790M but induced dimer formation in H1975L858R with no effect in H1975WT. Our data suggests that MET inhibition by SGX523 and EGFR-MET heterodimerisation are determined by EGFR genotype. As tumor behaviour is modulated by this interaction, this could determine treatment efficacy.

  18. Unified State Model theory and application in Astrodynamics

    NASA Astrophysics Data System (ADS)

    Vittaldev, V.; Mooij, E.; Naeije, M. C.

    2012-03-01

    The Unified State Model is a method for expressing orbits using a set of seven elements. The elements consist of a quaternion and three parameters based on the velocity hodograph. A complete derivation of the original model is given in addition to two proposed modifications. Both modifications reduce the number of state elements from seven to six by replacing the quaternion with either modified Rodrigues parameters or the Exponential Map. Numerical simulations comparing the original Unified State Model, the Unified State Model with modified Rodrigues parameters, and the Unified State Model with Exponential Map, with the traditional Cartesian coordinates have been carried out. The Unified State Model and its derivatives outperform the Cartesian coordinates for all orbit cases in terms of accuracy and computational speed, except for highly eccentric perturbed orbits. The performance of the Unified State Model is exceptionally better for the case of orbits with continuous low-thrust propulsion with CPU simulation time being an order of magnitude lower than for the simulation using Cartesian coordinates. This makes the Unified State Model an excellent state propagator for mission optimizations.

  19. Towards a unification of unified theories of biodiversity.

    PubMed

    McGill, Brian J

    2010-05-01

    A unified theory in science is a theory that shows a common underlying set of rules that regulate processes previously thought to be distinct. Unified theories have been important in physics including the unification of electricity and magnetism and the unification of the electromagnetic with the weak nuclear force. Surprisingly, ecology, specifically the subfields of biodiversity and macroecology, also possess not one but at least six unified theories. This is problematic as only one unified theory is desirable. Superficially, the six unified theories seem very different. However, I show that all six theories use the same three rules or assertions to describe a stochastic geometry of biodiversity. The three rules are: (1) intraspecifically individuals are clumped together; (2) interspecifically global or regional abundance varies according to a hollow curve distribution; and (3) interspecifically individuals are placed without regard to individuals of other species. These three rules appear sufficient to explain local species abundance distributions, species-area relationships, decay of similarity of distance and possibly other patterns of biodiversity. This provides a unification of the unified theories. I explore implications of this unified theory for future research.

  20. Structural Diversity in the AdoMet Radical Enzyme Superfamily

    PubMed Central

    Dowling, Daniel P.; Vey, Jessica L.; Croft, Anna K.; Drennan, Catherine L.

    2012-01-01

    AdoMet radical enzymes are involved in processes such as cofactor biosynthesis, anaerobic metabolism, and natural product biosynthesis. These enzymes utilize the reductive cleavage of S-adenosylmethionine (AdoMet) to afford L-methionine and a transient 5'-deoxyadenosyl radical, which subsequently generates a substrate radical species. By harnessing radical reactivity, the AdoMet radical enzyme superfamily is responsible for an incredible diversity of chemical transformations. Structural analysis reveals that family members adopt a full or partial Triose-phosphate Isomerase Mutase (TIM) barrel protein fold, containing core motifs responsible for binding a catalytic [4Fe-4S] cluster and AdoMet. Here we evaluate over twenty structures of AdoMet radical enzymes and classify them into two categories: traditional and ThiC-like (named for the structure of 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase (ThiC)). In light of new structural data, we reexamine the traditional structural motifs responsible for binding the [4Fe-4S] cluster and AdoMet, and compare and contrast these motifs with the ThiC case. We also review how structural data combine with biochemical, spectroscopic, and computational data to help us understand key features of this enzyme superfamily, such as the energetics, the triggering, and the molecular mechanisms of AdoMet reductive cleavage. PMID:22579873

  1. Mutations Preventing Regulated Exon Skipping in MET Cause Osteofibrous Dysplasia

    PubMed Central

    Gray, Mary J.; Kannu, Peter; Sharma, Swarkar; Neyt, Christine; Zhang, Dongping; Paria, Nandina; Daniel, Philip B.; Whetstone, Heather; Sprenger, Hans-Georg; Hammerschmidt, Philipp; Weng, Angela; Dupuis, Lucie; Jobling, Rebekah; Mendoza-Londono, Roberto; Dray, Michael; Su, Peiqiang; Wilson, Megan J.; Kapur, Raj P.; McCarthy, Edward F.; Alman, Benjamin A.; Howard, Andrew; Somers, Gino R.; Marshall, Christian R.; Manners, Simon; Flanagan, Adrienne M.; Rathjen, Karl E.; Karol, Lori A.; Crawford, Haemish; Markie, David M.; Rios, Jonathan J.; Wise, Carol A.; Robertson, Stephen P.

    2015-01-01

    The periosteum contributes to bone repair and maintenance of cortical bone mass. In contrast to the understanding of bone development within the epiphyseal growth plate, factors that regulate periosteal osteogenesis have not been studied as intensively. Osteofibrous dysplasia (OFD) is a congenital disorder of osteogenesis and is typically sporadic and characterized by radiolucent lesions affecting the cortical bone immediately under the periosteum of the tibia and fibula. We identified germline mutations in MET, encoding a receptor tyrosine kinase, that segregate with an autosomal-dominant form of OFD in three families and a mutation in a fourth affected subject from a simplex family and with bilateral disease. Mutations identified in all families with dominant inheritance and in the one simplex subject with bilateral disease abolished the splice inclusion of exon 14 in MET transcripts, which resulted in a MET receptor (METΔ14) lacking a cytoplasmic juxtamembrane domain. Splice exclusion of this domain occurs during normal embryonic development, and forced induction of this exon-exclusion event retarded osteoblastic differentiation in vitro and inhibited bone-matrix mineralization. In an additional subject with unilateral OFD, we identified a somatic MET mutation, also affecting exon 14, that substituted a tyrosine residue critical for MET receptor turnover and, as in the case of the METΔ14 mutations, had a stabilizing effect on the mature protein. Taken together, these data show that aberrant MET regulation via the juxtamembrane domain subverts core MET receptor functions that regulate osteogenesis within cortical diaphyseal bone. PMID:26637977

  2. 76 FR 5391 - Office of Biotechnology Activities, Office of Science Policy, Office of the Director

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-31

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Office of Biotechnology Activities, Office of Science Policy, Office of the Director Amended Notice of Meeting Notice is hereby given of a change in the...

  3. MET2 affects production of hydrogen sulfide during wine fermentation.

    PubMed

    Huang, Chien; Roncoroni, Miguel; Gardner, Richard C

    2014-08-01

    The production of hydrogen sulfide (H2S) during yeast fermentation contributes negatively to wine aroma. We have mapped naturally occurring mutations in commercial wine strains that affect production of H2S. A dominant R310G mutant allele of MET2, which encodes homoserine O-acetyltransferase, is present in several wine yeast strains as well as in the main lab strain S288c. Reciprocal hemizygosity and allele swap experiments demonstrated that the MET2 R310G allele confers reduced H2S production. Mutations were also identified in genes encoding the two subunits of sulfite reductase, MET5 and MET10, which were associated with reduced H2S production. The most severe of these, an allele of MET10, showed five additional phenotypes: reduced growth rate on sulfate, elevated secretion of sulfite, and reduced production in wine of three volatile sulfur compounds: methionol, carbon disulfide and methylthioacetate. Alleles of MET5 and MET10, but not MET2, affected H2S production measured by colour assays on BiGGY indicator agar, but MET2 effects were seen when bismuth was added to agar plates made with Sauvignon blanc grape juice. Collectively, the data are consistent with the hypothesis that H2S production during wine fermentation results predominantly from enzyme activity in the sulfur assimilation pathway. Lower H2S production results from mutations that reduce the activity of sulfite reductase, the enzyme that produces H2S, or that increase the activity of L-homoserine-O-acetyltransferase, which produces substrate for the next step in the sulfur assimilation pathway.

  4. FOXC2 promotes colorectal cancer metastasis by directly targeting MET.

    PubMed

    Cui, Y-M; Jiao, H-L; Ye, Y-P; Chen, C-M; Wang, J-X; Tang, N; Li, T-T; Lin, J; Qi, L; Wu, P; Wang, S-Y; He, M-R; Liang, L; Bian, X-W; Liao, W-T; Ding, Y-Q

    2015-08-13

    Metastasis is the major cause of death in colorectal cancer (CRC). Although multiple genes have been identified to be responsible for the development of CRC, the molecular changes that enable CRC cells to undergo early local invasion and to form distant metastatic colonies still remain largely unknown. Herein, we investigated the role of Forkhead box protein C2 (FOXC2) and explored the underlying mechanisms in invasion and metastasis of CRC. We show that both high FOXC2 expression and nuclear localization of FOXC2 are significantly correlated with advanced TNM (T=primary tumor; N=regional lymph nodes; M=distant metastasis) stages. FOXC2 enhanced the invasive abilities of CRC cells in vitro and promoted local invasion and distant metastasis in an orthotopic mouse metastatic model of CRC. Microarray analysis revealed that overexpression of FOXC2 increased the proto-oncogene MET tyrosine kinase expression and activated the hepatocyte growth factor (HGF)-MET signaling pathway. Furthermore, luciferase reporter assays and chromatin immunoprecipitation assays revealed that FOXC2 directly associated with MET promoter to increase the transcriptional activity of MET. Inhibition of MET attenuates the invasive phenotype and metastatic potential of FOXC2-overexpressing CRC cells, indicating that MET is a major mediator of FOXC2-promoted metastasis. In addition, FOXC2 expression was positively correlated with MET expression in CRC tissue samples. Our findings suggest that FOXC2 has a crucial role in CRC metastasis by regulating HGF-MET signaling via inducing MET expression, highlighting FOXC2 as a potential therapeutic target for preventing or reducing metastasis in CRC.

  5. An Examination of Tri-Level Collaboration around Student Achievement Using the Gap Analysis Approach: Central Office Leadership Factors

    ERIC Educational Resources Information Center

    Llamas, Sonia Rodarte

    2013-01-01

    Using the Gap Analysis problem-solving framework (Clark & Estes, 2008), this study examined collaboration around student achievement at the central office leadership level in the Pasadena Unified School District (PUSD). This study is one of three concurrent studies focused on collaboration around student achievement in the PUSD that include…

  6. An Examination of Tri-Level Collaboration around Student Achievement Using the Gap Analysis Approach: Central Office Leadership Factors

    ERIC Educational Resources Information Center

    Llamas, Sonia Rodarte

    2013-01-01

    Using the Gap Analysis problem-solving framework (Clark & Estes, 2008), this study examined collaboration around student achievement at the central office leadership level in the Pasadena Unified School District (PUSD). This study is one of three concurrent studies focused on collaboration around student achievement in the PUSD that include…

  7. MetNet Precursor - Network Mission to Mars

    NASA Astrophysics Data System (ADS)

    Harri, Arri-Matti

    2010-05-01

    We are developing a new kind of planetary exploration mission for Mars - MetNet in situ observation network based on a new semi-hard landing vehicle called the Met-Net Lander (MNL). The first MetNet vehicle, MetNet Precursor, slated for launch in 2011. The MetNet development work started already in 2001. The actual practical Precursor Mission development work started in January 2009 with participation from various space research institutes and agencies. The scientific rationale and goals as well as key mission solutions will be discussed. The eventual scope of the MetNet Mission is to deploy some 20 MNLs on the Martian surface using inflatable descent system structures, which will be supported by observations from the orbit around Mars. Currently we are working on the MetNet Mars Precursor Mission (MMPM) to deploy one MetNet Lander to Mars in the 2011 launch window as a technology and science demonstration mission. The MNL will have a versatile science payload focused on the atmospheric science of Mars. Time-resolved in situ Martian meteorological measurements acquired by the Viking, Mars Pathfinder and Phoenix landers and remote sensing observations by the Mariner 9, Viking, Mars Global Surveyor, Mars Odyssey and the Mars Express orbiters have provided the basis for our current understanding of the behavior of weather and climate on Mars. However, the available amount of data is still scarce and a wealth of additional in situ observations are needed on varying types of Martian orography, terrain and altitude spanning all latitudes and longitudes to address microscale and mesoscale atmospheric phenomena. Detailed characterization of the Martian atmospheric circulation patterns and climatological cycles requires simultaneous in situ atmospheric observations. The scientific payload of the MetNet Mission encompasses separate instrument packages for the atmospheric entry and descent phase and for the surface operation phase. The MetNet mission concept and key probe

  8. A unified model for yeast transcript definition

    PubMed Central

    de Boer, Carl G.; van Bakel, Harm; Tsui, Kyle; Li, Joyce; Morris, Quaid D.; Nislow, Corey; Greenblatt, Jack F.; Hughes, Timothy R.

    2014-01-01

    Identifying genes in the genomic context is central to a cell's ability to interpret the genome. Yet, in general, the signals used to define eukaryotic genes are poorly described. Here, we derived simple classifiers that identify where transcription will initiate and terminate using nucleic acid sequence features detectable by the yeast cell, which we integrate into a Unified Model (UM) that models transcription as a whole. The cis-elements that denote where transcription initiates function primarily through nucleosome depletion, and, using a synthetic promoter system, we show that most of these elements are sufficient to initiate transcription in vivo. Hrp1 binding sites are the major characteristic of terminators; these binding sites are often clustered in terminator regions and can terminate transcription bidirectionally. The UM predicts global transcript structure by modeling transcription of the genome using a hidden Markov model whose emissions are the outputs of the initiation and termination classifiers. We validated the novel predictions of the UM with available RNA-seq data and tested it further by directly comparing the transcript structure predicted by the model to the transcription generated by the cell for synthetic DNA segments of random design. We show that the UM identifies transcription start sites more accurately than the initiation classifier alone, indicating that the relative arrangement of promoter and terminator elements influences their function. Our model presents a concrete description of how the cell defines transcript units, explains the existence of nongenic transcripts, and provides insight into genome evolution. PMID:24170600

  9. A unified kinetic model for particle aggregation

    SciTech Connect

    Gardner, K.H.; Theis, T.L.

    1996-06-01

    Aggregation of submicrometer particles is a process with significant implications for the fate and transport of contaminants and major nutrients in many coastal, estuarine, and freshwater bodies as well as groundwater systems. A unified model has been developed that describes the kinetics of particle aggregation. The model is unique in the incorporation of surface chemical phenomena along with solution chemistry in the determination of the stability of a colloidal dispersion. The aggregation process is treated in a truly kinetic fashion, the main output from the model being the evolution of complete particle size distributions over time. The model was developed to interpret laboratory data and, as such, has the capacity to estimate a (variable) set of system parameters by fitting the size distribution over time data to that measured. It was found that the attachment distance, a parameter frequently approximated in practice, has a profound influence on the predicted aggregation kinetics as does the choice of a solid/solution interfacial model. Furthermore, simulation of relatively long-term aggregation, which was the principal focus of this work, indicates that values of the collision efficiency factor should be much smaller than those reported elsewhere in the literature.

  10. A Unified Picture of S* in Carotenoids

    PubMed Central

    2016-01-01

    In π-conjugated chain molecules such as carotenoids, coupling between electronic and vibrational degrees of freedom is of central importance. It governs both dynamic and static properties, such as the time scales of excited state relaxation as well as absorption spectra. In this work, we treat vibronic dynamics in carotenoids on four electronic states (|S0⟩, |S1⟩, |S2⟩, and |Sn⟩) in a physically rigorous framework. This model explains all features previously associated with the intensely debated S* state. Besides successfully fitting transient absorption data of a zeaxanthin homologue, this model also accounts for previous results from global target analysis and chain length-dependent studies. Additionally, we are able to incorporate findings from pump-deplete-probe experiments, which were incompatible to any pre-existing model. Thus, we present the first comprehensive and unified interpretation of S*-related features, explaining them by vibronic transitions on either S1, S0, or both, depending on the chain length of the investigated carotenoid. PMID:27509302

  11. Structural basis unifying diverse GTP hydrolysis mechanisms.

    PubMed

    Anand, Baskaran; Majumdar, Soneya; Prakash, Balaji

    2013-02-12

    Central to biological processes is the regulation rendered by GTPases. Until recently, the GTP hydrolysis mechanism, exemplified by Ras-family (and G-α) GTPases, was thought to be universal. This mechanism utilizes a conserved catalytic Gln supplied "in cis" from the GTPase and an arginine finger "in trans" from a GAP (GTPase activating protein) to stabilize the transition state. However, intriguingly different mechanisms are operative in structurally similar GTPases. MnmE and dynamin like cation-dependent GTPases lack the catalytic Gln and instead employ a Glu/Asp/Ser situated elsewhere and in place of the arginine finger use a K(+) or Na(+) ion. In contrast, Rab33 possesses the Gln but does not utilize it for catalysis; instead, the GAP supplies both a catalytic Gln and an arginine finger in trans. Deciphering the underlying principles that unify seemingly unrelated mechanisms is central to understanding how diverse mechanisms evolve. Here, we recognize that steric hindrance between active site residues is a criterion governing the mechanism employed by a given GTPase. The Arf-ArfGAP structure is testimony to this concept of spatial (in)compatibility of active site residues. This understanding allows us to predict an as yet unreported hydrolysis mechanism and clarifies unexplained observations about catalysis by Rab11 and the need for HAS-GTPases to employ a different mechanism. This understanding would be valuable for experiments in which abolishing GTP hydrolysis or generating constitutively active forms of a GTPase is important.

  12. A Unifying Theory of Branching Morphogenesis.

    PubMed

    Hannezo, Edouard; Scheele, Colinda L G J; Moad, Mohammad; Drogo, Nicholas; Heer, Rakesh; Sampogna, Rosemary V; van Rheenen, Jacco; Simons, Benjamin D

    2017-09-21

    The morphogenesis of branched organs remains a subject of abiding interest. Although much is known about the underlying signaling pathways, it remains unclear how macroscopic features of branched organs, including their size, network topology, and spatial patterning, are encoded. Here, we show that, in mouse mammary gland, kidney, and human prostate, these features can be explained quantitatively within a single unifying framework of branching and annihilating random walks. Based on quantitative analyses of large-scale organ reconstructions and proliferation kinetics measurements, we propose that morphogenesis follows from the proliferative activity of equipotent tips that stochastically branch and randomly explore their environment but compete neutrally for space, becoming proliferatively inactive when in proximity with neighboring ducts. These results show that complex branched epithelial structures develop as a self-organized process, reliant upon a strikingly simple but generic rule, without recourse to a rigid and deterministic sequence of genetically programmed events. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

  13. Unify the electromagnetic force and gravitation

    NASA Astrophysics Data System (ADS)

    Ming, Zheng Sheng

    2013-04-01

    In the process of mankind investigate natural rule: people know four kinds of force: electromagnetic force, gravitation, weak force, and strong force. Meanwhile people use these four kinds force to explain all phenomena in the Nature. Obviously people do not know their mechanism of origin until now. On the other hand, these four kinds force is the difference showing form of one force, is not it? For solve these questions and find their mechanism of origin, I do some experiments and discover that the moving photons produce gravitation. This discovery shows the origin of gravitation. Meanwhile I also do experiments show that light is a particle, but is not a wave-particle duality. My experiments show that the elementary particles moving produce gravitation and electromagnetic force, this effect also produce wave effect. That is to say my experiment and calculate not only reveal the origin of gravitation, but also reveal the origin of electric charge and magnetic force. Base on this I first unify the electromagnetic force and gravitation. The more detail see below website: https://www.lap-publishing.com/catalog/details/store/gb/book/978-3-8473-2658-8/mechanism-of-interaction-in-moving-matter

  14. Unify the electromagnetic force and gravitation

    NASA Astrophysics Data System (ADS)

    Sheng Ming, Zheng

    2013-04-01

    In the process of mankind investigate natural rule: people know four kinds of force: electromagnetic force, gravitation, weak force, and strong force. Meanwhile people use these four kinds force to explain all phenomena in the Nature. Obviously people do not know their mechanism of origin until now. On the other hand, these four kinds force is the difference showing form of one force, is not it? For solve these questions and find their mechanism of origin, I do some experiments and discover that the moving photons produce gravitation. This discovery shows the origin of gravitation. Meanwhile I also do experiments show that light is a particle, but is not a wave-particle duality. My experiments show that the elementary particles moving produce gravitation and electromagnetic force, this effect also produce wave effect. That is to say my experiment and calculate not only reveal the origin of gravitation, but also reveal the origin of electric charge and magnetic force. Base on this I first unify the electromagnetic force and gravitation. The more detail see below website: https://www.lap-publishing.com/catalog/details/store/gb/book/978-3-8473-2658-8/mechanism-of-interaction-in-moving-matter.

  15. Unified water isotherms for clayey porous materials

    NASA Astrophysics Data System (ADS)

    Revil, A.; Lu, N.

    2013-09-01

    We provide a unified model for the soil-water retention function, including the effect of bound and capillary waters for all types of soils, including clayey media. The model combines a CEC-normalized isotherm describing the sorption of the bound water (and the filling of the trapped porosity) and the van Genuchten model to describe the capillary water sorption retention but ignore capillary condensation. For the CEC-normalized isotherm, we tested both the BET and Freundlich isotherms, and we found that the Freundlich is more suitable than the BET isotherm in fitting the data. It is also easier to combine the Freundlich isotherm with the van Genuchten model. The new model accounts for (1) the different types of clay minerals, (2) the different types of ions sorbed in the Stern layer and on the basal planes of 2:1 clays, and (3) the pore size distribution. The model is validated with different data sets, including mixtures of kaolinite and bentonite. The model parameters include two exponents (the pore size exponent of the van Genuchten model and the exponent of the Freundlich isotherm), the capillary entry pressure, and two critical water contents. The first critical water content is the water content at saturation (porosity), and the second is the maximum water content associated with adsorption forces, including the trapped nonbound water.

  16. A Unified Taxonomy for Ciliary Dyneins

    PubMed Central

    Hom, Erik F.Y.; Witman, George B.; Harris, Elizabeth H.; Dutcher, Susan K.; Kamiya, Ritsu; Mitchell, David R.; Pazour, Gregory J.; Porter, Mary E.; Sale, Winfield S.; Wirschell, Maureen; Yagi, Toshiki; King, Stephen M.

    2011-01-01

    The formation and function of eukaryotic cilia/flagella require the action of a large array of dynein microtubule motor complexes. Due to genetic, biochemical, and microscopic tractability, Chlamydomonas reinhardtii has become the premier model system in which to dissect the role of dyneins in flagellar assembly, motility, and signaling. Currently, fifty-four proteins have been described as components of various Chlamydomonas flagellar dyneins or as factors required for their assembly in the cytoplasm and/or transport into the flagellum; orthologues of nearly all these components are present in other ciliated organisms including humans. For historical reasons, the nomenclature of these diverse dynein components and their corresponding genes, mutant alleles and orthologues has become extraordinarily confusing. Here, we unify Chlamydomonas dynein gene nomenclature and establish a systematic classification scheme based on structural properties of the encoded proteins. Furthermore, we provide detailed tabulations of the various mutant alleles and protein aliases that have been used and explicitly define the correspondence with orthologous components in other model organisms and humans. PMID:21953912

  17. UPM: unified policy-based network management

    NASA Astrophysics Data System (ADS)

    Law, Eddie; Saxena, Achint

    2001-07-01

    Besides providing network management to the Internet, it has become essential to offer different Quality of Service (QoS) to users. Policy-based management provides control on network routers to achieve this goal. The Internet Engineering Task Force (IETF) has proposed a two-tier architecture whose implementation is based on the Common Open Policy Service (COPS) protocol and Lightweight Directory Access Protocol (LDAP). However, there are several limitations to this design such as scalability and cross-vendor hardware compatibility. To address these issues, we present a functionally enhanced multi-tier policy management architecture design in this paper. Several extensions are introduced thereby adding flexibility and scalability. In particular, an intermediate entity between the policy server and policy rule database called the Policy Enforcement Agent (PEA) is introduced. By keeping internal data in a common format, using a standard protocol, and by interpreting and translating request and decision messages from multi-vendor hardware, this agent allows a dynamic Unified Information Model throughout the architecture. We have tailor-made this unique information system to save policy rules in the directory server and allow executions of policy rules with dynamic addition of new equipment during run-time.

  18. A unified model for yeast transcript definition.

    PubMed

    de Boer, Carl G; van Bakel, Harm; Tsui, Kyle; Li, Joyce; Morris, Quaid D; Nislow, Corey; Greenblatt, Jack F; Hughes, Timothy R

    2014-01-01

    Identifying genes in the genomic context is central to a cell's ability to interpret the genome. Yet, in general, the signals used to define eukaryotic genes are poorly described. Here, we derived simple classifiers that identify where transcription will initiate and terminate using nucleic acid sequence features detectable by the yeast cell, which we integrate into a Unified Model (UM) that models transcription as a whole. The cis-elements that denote where transcription initiates function primarily through nucleosome depletion, and, using a synthetic promoter system, we show that most of these elements are sufficient to initiate transcription in vivo. Hrp1 binding sites are the major characteristic of terminators; these binding sites are often clustered in terminator regions and can terminate transcription bidirectionally. The UM predicts global transcript structure by modeling transcription of the genome using a hidden Markov model whose emissions are the outputs of the initiation and termination classifiers. We validated the novel predictions of the UM with available RNA-seq data and tested it further by directly comparing the transcript structure predicted by the model to the transcription generated by the cell for synthetic DNA segments of random design. We show that the UM identifies transcription start sites more accurately than the initiation classifier alone, indicating that the relative arrangement of promoter and terminator elements influences their function. Our model presents a concrete description of how the cell defines transcript units, explains the existence of nongenic transcripts, and provides insight into genome evolution.

  19. A Unifying Theory for Camera Calibration.

    PubMed

    Ramalingam, SriKumar; Sturm, Peter

    2016-07-19

    This paper proposes a unified theory for calibrating a wide variety of camera models such as pinhole, fisheye, cata-dioptric, and multi-camera networks. We model any camera as a set of image pixels and their associated camera rays in space. Every pixel measures the light traveling along a (half-) ray in 3-space, associated with that pixel. By this definition, calibration simply refers to the computation of the mapping between pixels and the associated 3D rays. Such a mapping can be computed using images of calibration grids, which are objects with known 3D geometry, taken from unknown positions. This general camera model allows to represent non-central cameras; we also consider two special subclasses, namely central and axial cameras. In a central camera, all rays intersect in a single point, whereas the rays are completely arbitrary in a non-central one. Axial cameras are an intermediate case: the camera rays intersect a single line. In this work, we show the theory for calibrating central, axial and non-central models using calibration grids, which can be either three-dimensional or planar.

  20. The Unified Lunar Control Network 2005

    USGS Publications Warehouse

    Archinal, Brent A.; Rosiek, Mark R.; Kirk, Randolph L.; Redding, Bonnie L.

    2006-01-01

    This report documents a new general unified lunar control network and lunar topographic model based on a combination of Clementine images and a previous network derived from Earth-based & Apollo photographs, and Mariner 10, & Galileo images. This photogrammetric network solution is the largest planetary control network ever completed. It includes the determination of the 3-D positions of 272,931 points on the lunar surface and the correction of the camera angles for 43,866 Clementine images, using 546,126 tie point measurements. The solution RMS is 20 ?m (= 0.9 pixels) in the image plane, with the largest residual of 6.4 pixels. The explanation given here, along with the accompanying files, comprises the release of the network information and of global lunar digital elevation models (DEMs) derived from the network. A paper that will describe the solution and network in further detail will be submitted to a refereed journal, and will include additional background information, solution details, discussion of accuracy and precision, and explanatory figures.

  1. Unifying Temporal and Structural Credit Assignment Problems

    NASA Technical Reports Server (NTRS)

    Agogino, Adrian K.; Tumer, Kagan

    2004-01-01

    Single-agent reinforcement learners in time-extended domains and multi-agent systems share a common dilemma known as the credit assignment problem. Multi-agent systems have the structural credit assignment problem of determining the contributions of a particular agent to a common task. Instead, time-extended single-agent systems have the temporal credit assignment problem of determining the contribution of a particular action to the quality of the full sequence of actions. Traditionally these two problems are considered different and are handled in separate ways. In this article we show how these two forms of the credit assignment problem are equivalent. In this unified frame-work, a single-agent Markov decision process can be broken down into a single-time-step multi-agent process. Furthermore we show that Monte-Carlo estimation or Q-learning (depending on whether the values of resulting actions in the episode are known at the time of learning) are equivalent to different agent utility functions in a multi-agent system. This equivalence shows how an often neglected issue in multi-agent systems is equivalent to a well-known deficiency in multi-time-step learning and lays the basis for solving time-extended multi-agent problems, where both credit assignment problems are present.

  2. 75 FR 15713 - Office of Biotechnology Activities; Office of Science Policy; Office of the Director; Notice of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-30

    ... HUMAN SERVICES National Institutes of Health Office of Biotechnology Activities; Office of Science..., Advisory Committee Coordinator, Office of Biotechnology Activities, Office of Science Policy, Office of the... of Biotechnology Activities, National Institutes of Health. BILLING CODE 4140-01-P ...

  3. Reduced hippocampus volume and memory performance in bipolar disorder patients carrying the BDNF val66met met allele.

    PubMed

    Cao, Bo; Bauer, Isabelle E; Sharma, Ajaykumar N; Mwangi, Benson; Frazier, Thomas; Lavagnino, Luca; Zunta-Soares, Giovana B; Walss-Bass, Consuelo; Glahn, David C; Kapczinski, Flavio; Nielsen, David A; Soares, Jair C

    2016-07-01

    Previous studies investigated the impact of brain-derived neurotrophic factor (BDNF) val66met (rs6265) on hippocampus volumes and neurocognition in bipolar disorders (BD), but the results were not consistent. This study aimed to investigate the effect of BDNF polymorphism on hippocampus volumes and memory performance in well-characterized adult populations diagnosed with type I BD (BD-I) and major depressive disorder (MDD) compared with healthy controls (HC). 48 BD-I patients, 33 MDD patients and 60 HC were genotyped for BDNF rs6265 using DNA isolated from white blood cells. Individuals with val/met and met/met genotypes were grouped as met carriers and compared to those with the val/val. Brain segmentations were obtained from structural magnetic resonance imaging (MRI) using the Freesurfer. Memory performance was assessed with the California Verbal Learning Task (CVLT). We found a significant diagnosis effect and marginal interaction between diagnosis and BDNF genotype group for both hippocampus volumes and memory performance. BDNF met allele carrier BD patients had smaller hippocampus volumes and reduced performance on multiple CVLT scores compared to MDD patients and HC. We provide strong evidence for the BDNF val66met polymorphism as a putative biological signature for the neuroanatomical and cognitive abnormalities commonly observed in BD patients. Copyright © 2016 Elsevier B.V. All rights reserved.

  4. High-protein meal challenge reveals the association between the salivary cortisol response and metabolic syndrome in police officers.

    PubMed

    Baughman, Penelope; Andrew, Michael E; Burchfiel, Cecil M; Fekedulegn, Desta; Hartley, Tara A; Violanti, John M; Miller, Diane B

    2016-01-01

    Policing is considered a high-stress occupation and officers have elevated cardiovascular morbidity and mortality. To investigate a potential connection, we evaluated the association between salivary cortisol response to a high-protein meal challenge and the metabolic syndrome (MetSyn), a subclinical disorder associated with increased cardiovascular risk. Cross-sectional data were from the Buffalo Cardio-Metabolic Occupational Police Stress (BCOPS) Study (2004-2009). MetSyn was defined as having ≥3 components: abdominal obesity, hypertension, elevated triglycerides, reduced high-density lipoprotein cholesterol, and glucose intolerance. Officers provided five saliva samples for cortisol analysis, one before challenge (high-protein shake) and four at 15-min intervals thereafter, where the usual response is increase. Regression models were used to examine trends in mean number of MetSyn components across quartiles of area under the curve (AUC) salivary cortisol. Patterns of mean cortisol response were assessed by MetSyn status using repeated-measures analysis of covariance. Prevalence of MetSyn was 25.7% among 373 officers (74.0% male). The mean count of MetSyn components decreased (1.89, 1.75, 1.55, 1.37; P < 0.01) across increasing quartiles of AUC salivary cortisol. Mean salivary cortisol decreased from baseline (5.55, 4.58, 4.47, 4.79, 4.75 nmol/l) in officers with MetSyn and increased (5.08, 5.82, 5.92, 5.82, 5.60 nmol/l) in their counterparts. The test for interaction between MetSyn status and time of saliva collection was statistically significant (P < 0.001). Reduced cortisol response to a high-protein meal challenge may be associated with MetSyn. Future longitudinal studies could provide useful evidence for planning intervention studies on cardiovascular risk among police officers. © 2015 Wiley Periodicals, Inc.

  5. Greening Government Offices

    DTIC Science & Technology

    2009-05-01

    labeled products are generally 20 percent more water- efficient than similar products  Green Seal Assesses a broad range of environmental impacts ... environmental impacts of paper production and dis posal. The underlying data are updated regularly. v mGo Links » v...Purchasing green office products  Reducing fuel consumption  Saving water and energy  Calculating environmental benefits  Eliciting behavior change

  6. Marine Officer Attrition Model.

    DTIC Science & Technology

    1984-06-01

    DISTRISUTION STATEMEANT (.1 lAg.Rpo) * Approved for public release; Distribution unlimited * I7. DISTRIGUTION STATEMENT (of the abstract @new A 01.0 2 ...Informat y Scitnces 2 ’I.I AISISACT Fredicting officer attrition is a major difficulty in the Elamaing, Programming, and Budgeting Process. The marine...For °. **** A vjl lbiitv Cod*S i S z,.npl/r. .** ~. .~d .’. **~ * * % >.,. >~. . * * ~****** * *** *- **.*%** 21JBLE CP CGITZITS 2 |2157CDOCTIONl

  7. Regular Expression-Based Learning for METs Value Extraction.

    PubMed

    Redd, Douglas; Kuang, Jinqiu; Mohanty, April; Bray, Bruce E; Zeng-Treitler, Qing

    2016-01-01

    Functional status as measured by exercise capacity is an important clinical variable in the care of patients with cardiovascular diseases. Exercise capacity is commonly reported in terms of Metabolic Equivalents (METs). In the medical records, METs can often be found in a variety of clinical notes. To extract METs values, we adapted a machine-learning algorithm called REDEx to automatically generate regular expressions. Trained and tested on a set of 2701 manually annotated text snippets (i.e. short pieces of text), the regular expressions were able to achieve good accuracy and F-measure of 0.89 and 0.86. This extraction tool will allow us to process the notes of millions of cardiovascular patients and extract METs value for use by researchers and clinicians.

  8. Loss of embryonic MET signaling alters profiles of hippocampal interneurons.

    PubMed

    Martins, Gabriela J; Plachez, Céline; Powell, Elizabeth M

    2007-01-01

    Hippocampal interneurons arise in the ventral forebrain and migrate dorsally in response to cues, including hepatocyte growth factor/scatter factor which signals via its receptor MET. Examination of the hippocampus in adult mice in which MET had been inactivated in the embryonic proliferative zones showed an increase in parvalbumin-expressing cells in the dentate gyrus, but a loss of these cells in the CA3 region. An overall loss of calretinin-expressing cells was seen throughout the hippocampus. A similar CA3 deficit of parvalbumin and calretinin cells was observed when MET was eliminated only in postmitotic cells. These data suggest that MET is required for the proper hippocampal development, and embryonic perturbations lead to long-term anatomical defects with possible learning and memory dysfunction.

  9. Regular Expression-Based Learning for METs Value Extraction

    PubMed Central

    Redd, Douglas; Kuang, Jinqiu; Mohanty, April; Bray, Bruce E.; Zeng-Treitler, Qing

    2016-01-01

    Functional status as measured by exercise capacity is an important clinical variable in the care of patients with cardiovascular diseases. Exercise capacity is commonly reported in terms of Metabolic Equivalents (METs). In the medical records, METs can often be found in a variety of clinical notes. To extract METs values, we adapted a machine-learning algorithm called REDEx to automatically generate regular expressions. Trained and tested on a set of 2701 manually annotated text snippets (i.e. short pieces of text), the regular expressions were able to achieve good accuracy and F-measure of 0.89 and 0.86. This extraction tool will allow us to process the notes of millions of cardiovascular patients and extract METs value for use by researchers and clinicians. PMID:27570673

  10. Mars MetNet Mission - Martian Atmospheric Observational Post Network

    NASA Astrophysics Data System (ADS)

    Hari, Ari-Matti; Haukka, Harri; Aleksashkin, Sergey; Arruego, Ignacio; Schmidt, Walter; Genzer, Maria; Vazquez, Luis; Siikonen, Timo; Palin, Matti

    2017-04-01

    A new kind of planetary exploration mission for Mars is under development in collaboration between the Finnish Meteorological Institute (FMI), Lavochkin Association (LA), Space Research Institute (IKI) and Institutio Nacional de Tecnica Aerospacial (INTA). The Mars MetNet mission is based on a new semi-hard landing vehicle called MetNet Lander (MNL). The scientific payload of the Mars MetNet Precursor [1] mission is divided into three categories: Atmospheric instruments, Optical devices and Composition and structure devices. Each of the payload instruments will provide significant insights in to the Martian atmospheric behavior. The key technologies of the MetNet Lander have been qualified and the electrical qualification model (EQM) of the payload bay has been built and successfully tested. 1. MetNet Lander The MetNet landing vehicles are using an inflatable entry and descent system instead of rigid heat shields and parachutes as earlier semi-hard landing devices have used. This way the ratio of the payload mass to the overall mass is optimized. The landing impact will burrow the payload container into the Martian soil providing a more favorable thermal environment for the electronics and a suitable orientation of the telescopic boom with external sensors and the radio link antenna. It is planned to deploy several tens of MNLs on the Martian surface operating at least partly at the same time to allow meteorological network science. 2. Strawman Scientific Payload The strawman payload of the two MNL precursor models includes the following instruments: Atmospheric instruments: - MetBaro Pressure device - MetHumi Humidity device - MetTemp Temperature sensors Optical devices: - PanCam Panoramic - MetSIS Solar irradiance sensor with OWLS optical wireless system for data transfer - DS Dust sensor Composition and Structure Devices: Tri-axial magnetometer MOURA Tri-axial System Accelerometer The descent processes dynamic properties are monitored by a special 3-axis

  11. Automated office blood pressure.

    PubMed

    Myers, Martin G; Godwin, Marshall

    2012-05-01

    Manual blood pressure (BP) is gradually disappearing from clinical practice with the mercury sphygmomanometer now considered to be an environmental hazard. Manual BP is also subject to measurement error on the part of the physician/nurse and patient-related anxiety which can result in poor quality BP measurements and office-induced (white coat) hypertension. Automated office (AO) BP with devices such as the BpTRU (BpTRU Medical Devices, Coquitlam, BC) has already replaced conventional manual BP in many primary care practices in Canada and has also attracted interest in other countries where research studies using AOBP have been undertaken. The basic principles of AOBP include multiple readings taken with a fully automated recorder with the patient resting alone in a quiet room. When these principles are followed, office-induced hypertension is eliminated and AOBP exhibits a much stronger correlation with the awake ambulatory BP as compared with routine manual BP measurements. Unlike routine manual BP, AOBP correlates as well with left ventricular mass as does the awake ambulatory BP. AOBP also simplifies the definition of hypertension in that the cut point for a normal AOBP (< 135/85 mm Hg) is the same as for the awake ambulatory BP and home BP. This article summarizes the currently available evidence supporting the use of AOBP in routine clinical practice and proposes an algorithm in which AOBP replaces manual BP for the diagnosis and management of hypertension.

  12. 40. PRESIDENT, OFFICERS AND DEPARTMENT HEADS MEET IN PRESIDENT'S OFFICE, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    40. PRESIDENT, OFFICERS AND DEPARTMENT HEADS MEET IN PRESIDENT'S OFFICE, PUBLISHED IN A BOOK, 'A SYMBOL OF SAFETY' BY HARRY CHASE BREARLEY, 1923 - Underwriters' Laboratories, 207-231 East Ohio Street, Chicago, Cook County, IL

  13. Office Skills: Realistic Evaluation in Office Education Programs.

    ERIC Educational Resources Information Center

    Shinn, Larry

    1979-01-01

    To evaluate office occupations realistically, evaluation procedure criteria were developed using office simulation techniques. Grading methods given cover quality, quantity, attenance, tardiness, use of time, and cost of extra supplies, with grade penalties for performance deficiencies. (MF)

  14. 20. OFFICE AT NORTH END OF SECOND FLOOR, ADMINISTRATIVE OFFICES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. OFFICE AT NORTH END OF SECOND FLOOR, ADMINISTRATIVE OFFICES SECTION. VIEW TO SOUTHEAST. - Ford Motor Company Long Beach Assembly Plant, Assembly Building, 700 Henry Ford Avenue, Long Beach, Los Angeles County, CA

  15. Design and Implementation of Image Research for the Columbia Mets

    DTIC Science & Technology

    1992-01-01

    respondents have at least attended college or are college graduates. This figure is almost 30% higher than the Major League Baseball average of 52...appreciation to the staff of the Columbia Mets. I thank Dr. Eric Margenau, Owner/President of the Mets and president of United Baseball , Inc., for...most important and special person in my life, my wife Diane. God blessed you with an abundance of patience in putting up with my love baseball

  16. MMPM - Mission implementation of Mars MetNet Precursor

    NASA Astrophysics Data System (ADS)

    Harri, A.-M.

    2009-04-01

    We are developing a new kind of planetary exploration mission for Mars - MetNet in situ observation network based on a new semi-hard landing vehicle called the Met-Net Lander (MNL). The key technical aspects and solutions of the mission will be discussed. The eventual scope of the MetNet Mission is to deploy some 20 MNLs on the Martian surface using inflatable descent system structures, which will be supported by observations from the orbit around Mars. Currently we are working on the MetNet Mars Precursor Mission (MMPM) to deploy one MetNet Lander to Mars in the 2009/2011 launch window as a technology and science demonstration mission. The MNL will have a versatile science payload focused on the atmospheric science of Mars. Detailed characterization of the Martian atmospheric circulation patterns, boundary layer phenomena, and climatology cycles, require simultaneous in-situ measurements by a network of observation posts on the Martian surface. The scientific payload of the MetNet Mission encompasses separate instrument packages for the atmospheric entry and descent phase and for the surface operation phase. The MetNet mission concept and key probe technologies have been developed and the critical subsystems have been qualified to meet the Martian environmental and functional conditions. This development effort has been fulfilled in collaboration between the Finnish Meteorological Institute (FMI), the Russian Lavoschkin Association (LA) and the Russian Space Research Institute (IKI) since August 2001. Currently the INTA (Instituto Nacional de Técnica Aeroespacial) from Spain is also participating in the MetNet payload development.

  17. 24 CFR 578.41 - Unified Funding Agency costs.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... § 578.41 Unified Funding Agency costs. (a) In general. UFAs may use up to 3 percent of their FPRN, or a... under the Continuum of Care program. (b) UFA costs. UFA costs include costs of ensuring that...

  18. Unified resource development of the Tennessee River watershed. Appendix

    SciTech Connect

    Not Available

    1983-04-01

    This volume contains: the TVA act, the 1936 report to the Congress on the unified development of the Tennessee River system, a history of the TVA, generator/motor specifications, and ac induction motor (squirrel-cage type) specifications. (DLC)

  19. A Unified Mathematical Definition of Classical Information Retrieval.

    ERIC Educational Resources Information Center

    Dominich, Sandor

    2000-01-01

    Presents a unified mathematical definition for the classical models of information retrieval and identifies a mathematical structure behind relevance feedback. Highlights include vector information retrieval; probabilistic information retrieval; and similarity information retrieval. (Contains 118 references.) (Author/LRW)

  20. A Unified Mathematical Definition of Classical Information Retrieval.

    ERIC Educational Resources Information Center

    Dominich, Sandor

    2000-01-01

    Presents a unified mathematical definition for the classical models of information retrieval and identifies a mathematical structure behind relevance feedback. Highlights include vector information retrieval; probabilistic information retrieval; and similarity information retrieval. (Contains 118 references.) (Author/LRW)

  1. North Coast Unified Air Quality Management District: PSD Delegation Agreements

    EPA Pesticide Factsheets

    Agreements for Partial Delegation of the Federal Prevention of Significant Deterioration (PSD) Program Set Forth in 40 CPR 52.21 by the United States Environmental Protection Agency, Region 9 to the North Coast Unified Air Quality Management District.

  2. COMT val158met predicts reward responsiveness in humans.

    PubMed

    Lancaster, T M; Linden, D E; Heerey, E A

    2012-11-01

    A functional variant of the catechol-O-methyltransferase (COMT) gene [val158met (rs4680)] is frequently implicated in decision-making and higher cognitive functions. It may achieve its effects by modulating dopamine-related decision-making and reward-guided behaviour. Here we demonstrate that individuals with the met/met polymorphism have greater responsiveness to reward than carriers of the val allele and that this correlates with risk-seeking behaviour. We assessed performance on a reward responsiveness task and the Balloon analogue risk task, which measure how participants (N = 70, western European, university and postgraduate students) respond to reward and take risks in the presence of available reward. Individuals with the met/met genotype (n = 19) showed significantly higher reward responsiveness, F2,64 = 4.02, P = 0.02, and reward-seeking behaviour, F(2,68) = 4.52, P = 0.01, than did either val/met (n = 25) or val/val (n = 26) carriers. These results highlight a scenario in which genotype-dependent reward responsiveness shapes reward-seeking, therefore suggesting a novel framework by which COMT may modulate behaviour. © 2012 The Authors. Genes, Brain and Behavior © 2012 Blackwell Publishing Ltd and International Behavioural and Neural Genetics Society.

  3. VIEW EAST, WEST SIDE OF TWOSTORY OFFICE BUILDING, ONESTORY OFFICE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW EAST, WEST SIDE OF TWO-STORY OFFICE BUILDING, ONE-STORY OFFICE BUILDING, AND HEBERTS 1949 HANGAR, AND VIEW OF SOUTH SIDE OF TWO-STORY OFFICE BUILDING AND NORTH SIDE OF HEBERTS 1949 HANGAR - Capital City Airport, Capital City Aviation, North side of Grand River Avenue, Lansing, Ingham County, MI

  4. Annual Report 2008 -- Office of the Chief Financial Officer (OCFO)

    SciTech Connect

    Fernandez, Jeffrey

    2008-12-22

    It is with great pleasure that I present to you the 2008 Chief Financial Officer's Annual Report. The data included in this report has been compiled from the Budget Office, the Controller, Procurement and Property Management and the Sponsored Projects Office. Also included are some financial comparisons with other DOE Laboratories and a glossary of commonly used acronyms.

  5. The Unified Behavior Framework for the Simulation of Autonomous Agents

    DTIC Science & Technology

    2015-03-01

    control framework, known as the Unified Behavior Framework, has proven to be an effective method for autonomous robot agents. By implementing this...architecture, the Unified Behavior Framework (UBF), implements a variation of the three-layer architecture with a reactive controller to rapidly make...2.2: A depiction of two of Braitenberg’s “Vehicles” which inspired the behavioral perspective of autonomous robot control [3]. The vehicle on the left

  6. 29 CFR 779.217 - “Unified operation” defined.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 3 2012-07-01 2012-07-01 false âUnified operationâ defined. 779.217 Section 779.217 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR STATEMENTS OF GENERAL... Or Common Control § 779.217 “Unified operation” defined. Webster defines the word “unify” to mean “to...

  7. 29 CFR 779.217 - “Unified operation” defined.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 3 2014-07-01 2014-07-01 false âUnified operationâ defined. 779.217 Section 779.217 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR STATEMENTS OF GENERAL... Or Common Control § 779.217 “Unified operation” defined. Webster defines the word “unify” to mean “to...

  8. 29 CFR 779.217 - “Unified operation” defined.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 3 2013-07-01 2013-07-01 false âUnified operationâ defined. 779.217 Section 779.217 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR STATEMENTS OF GENERAL... Or Common Control § 779.217 “Unified operation” defined. Webster defines the word “unify” to mean “to...

  9. Finite unified theories: Theoretical basis and phenomenological implications

    NASA Astrophysics Data System (ADS)

    Mondragón, M.; Zoupanos, G.

    2011-05-01

    All-loop Finite Unified Theories (FUTs) arc very interesting N = 1 supersymmetric Grand Unified Theories (GUTs) which not only realise an old field theoretic dream, but also have a remarkable predictive power due to the required reduction of couplings. Here we present FUT models based on SU(5) and SU(3)3 gauge groups and their predictions. Of particular interest is the Higgs mass prediction of one of the models which is expected to be tested at the LHC.

  10. Effect of individual Fc methionine oxidation on FcRn binding: Met252 oxidation impairs FcRn binding more profoundly than Met428 oxidation.

    PubMed

    Gao, Xuan; Ji, Junyan A; Veeravalli, Karthik; Wang, Y John; Zhang, Taylor; Mcgreevy, William; Zheng, Kai; Kelley, Robert F; Laird, Michael W; Liu, Jun; Cromwell, Mary

    2015-02-01

    The long serum half-lives of mAbs are conferred by pH-dependent binding of IgG-Fc to the neonatal Fc receptor (FcRn). The Fc region of human IgG1 has three conserved methionine residues, Met252, Met358, and Met428. Recent studies showed oxidation of these Met residues impairs FcRn binding and consequently affects pharmacokinetics of therapeutic antibodies. However, the quantitative effect of individual Met oxidation on Fc-FcRn binding has not been addressed. This information is valuable for defining critical quality attributes. In the present study, two sets of homodimeric site-directed IgG1 mutations were generated to understand how individual Fc Met oxidation affects FcRn binding. The first approach used Met to Leu mutants to block site-specific Met oxidation. In the other approach, Met to Gln mutants were designed to mimic site-specific Met oxidation. Both mutagenesis approaches show that either Met252 or Met428 oxidation alone significantly impairs Fc-FcRn binding. Met252 oxidation has a more deleterious effect on FcRn binding than M428 oxidation, whereas Met428 oxidation has a bigger destabilization effect on the thermal stability. Our results also show that Met358 oxidation does not affect FcRn binding. In addition, our study suggests that Met to Gln mutation may serve as an important tool to understand Met oxidation. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.

  11. Mars MetNet Mission - Martian Atmospheric Observational Post Network

    NASA Astrophysics Data System (ADS)

    Harri, Ari-Matti; Aleksashkin, Sergey; Arruego, Ignacio; Schmidt, Walter; Ponomarenko, Andrey; Apestigue, Victor; Genzer, Maria; Vazquez, Luis; Uspensky, Mikhail; Haukka, Harri

    2016-04-01

    A new kind of planetary exploration mission for Mars is under development in collaboration between the Finnish Meteorological Institute (FMI), Lavochkin Association (LA), Space Research Institute (IKI) and Institutio Nacional de Tecnica Aerospacial (INTA). The Mars MetNet mission is based on a new semi-hard landing vehicle called MetNet Lander (MNL). The scientific payload of the Mars MetNet Precursor [1] mission is divided into three categories: Atmospheric instruments, Optical devices and Composition and structure devices. Each of the payload instruments will provide significant insights in to the Martian atmospheric behavior. The key technologies of the MetNet Lander have been qualified and the electrical qualification model (EQM) of the payload bay has been built and successfully tested. MetNet Lander The MetNet landing vehicles are using an inflatable entry and descent system instead of rigid heat shields and parachutes as earlier semi-hard landing devices have used. This way the ratio of the payload mass to the overall mass is optimized. The landing impact will burrow the payload container into the Martian soil providing a more favorable thermal environment for the electronics and a suitable orientation of the telescopic boom with external sensors and the radio link antenna. It is planned to deploy several tens of MNLs on the Martian surface operating at least partly at the same time to allow meteorological network science. Strawman Scientific Payload The strawman payload of the two MNL precursor models includes the following instruments: Atmospheric instruments: • MetBaro Pressure device • MetHumi Humidity device • MetTemp Temperature sensors Optical devices: • PanCam Panoramic • MetSIS Solar irradiance sensor with OWLS optical wireless system for data transfer • DS Dust sensor Composition and Structure Devices: • Tri-axial magnetometer MOURA • Tri-axial System Accelerometer The descent processes dynamic properties are monitored by a special

  12. A unified paraxial approach to astigmatic optics.

    PubMed

    Harris, W F

    1999-07-01

    In Gaussian optics properties such as dioptric power, lateral and angular magnification and thickness are simple scalar concepts. In linear optics, the optics of thick astigmatic systems, however, these concepts generalize to three-dimensional concepts in some cases (the dioptric power of thin systems, for example) and to four-dimensional concepts in general. As a result, the quantitative treatment of these properties in astigmatic systems presents challenges to the researcher in optometry, ophthalmology, and vision science. Considerable progress has been made only in the case of dioptric power. This paper presents a generalized approach to astigmatic optics which allows different physical properties to be treated in the same way: the theory is unified and, in a sense, complete. Mathematical and statistical methods developed for treating one concept become directly applicable to others. The paraxial optical properties of any optical system are completely defined by the 4 x 4 ray transfer matrix, called here the (ray) transference. The transference defines four fundamental properties of an optical system, tentatively called here positional magnification, optical thickness, divergence, and directional magnification. They are the four 2 x 2 submatrices A, B, C, and D of the transference. Each fundamental property is a modification of a familiar concept. Divergence is the negative of dioptric power expressed as the dioptric power matrix F. The four fundamental optical properties A, B, C, and D, and the derived property F, despite being different physically, all have the same underlying mathematical structure. This fact is exploited in developing a unified theory. The theory is complete in the sense that the fundamental properties fully characterize the paraxial optics of any system. The paper presents a general treatment that applies to any of the five properties. The implications are far reaching and extend beyond what can be described in the paper. Dioptric power of

  13. Evolutionary mechanism unifies the hallmarks of cancer.

    PubMed

    Horne, Steven D; Pollick, Sarah A; Heng, Henry H Q

    2015-05-01

    The basis for the gene mutation theory of cancer that dominates current molecular cancer research consists of: the belief that gene-level aberrations such as mutations are the main cause of cancers, the concept that stepwise gene mutation accumulation drives cancer progression, and the hallmarks of cancer. The research community swiftly embraced the hallmarks of cancer, as such synthesis has supported the notions that common cancer genes are responsible for the majority of cancers and the complexity of cancer can be dissected into simplified molecular principles. The gene/pathway classification based on individual hallmarks provides explanation for the large number of diverse gene mutations, which is in contrast to the original estimation that only a handful of gene mutations would be discovered. Further, these hallmarks have been highly influential as they also provide the rationale and research direction for continued gene-based cancer research. While the molecular knowledge of these hallmarks is drastically increasing, the clinical implication remains limited, as cancer dynamics cannot be summarized by a few isolated/fixed molecular principles. Furthermore, the highly heterogeneous genetic signature of cancers, including massive stochastic genome alterations, challenges the utility of continuously studying each individual gene mutation under the framework of these hallmarks. It is therefore necessary to re-evaluate the concept of cancer hallmarks through the lens of cancer evolution. In this analysis, the evolutionary basis for the hallmarks of cancer will be discussed and the evolutionary mechanism of cancer suggested by the genome theory will be employed to unify the diverse molecular mechanisms of cancer.

  14. A unified approach to sparse signal processing

    NASA Astrophysics Data System (ADS)

    Marvasti, Farokh; Amini, Arash; Haddadi, Farzan; Soltanolkotabi, Mahdi; Khalaj, Babak Hossein; Aldroubi, Akram; Sanei, Saeid; Chambers, Janathon

    2012-12-01

    A unified view of the area of sparse signal processing is presented in tutorial form by bringing together various fields in which the property of sparsity has been successfully exploited. For each of these fields, various algorithms and techniques, which have been developed to leverage sparsity, are described succinctly. The common potential benefits of significant reduction in sampling rate and processing manipulations through sparse signal processing are revealed. The key application domains of sparse signal processing are sampling, coding, spectral estimation, array processing, component analysis, and multipath channel estimation. In terms of the sampling process and reconstruction algorithms, linkages are made with random sampling, compressed sensing, and rate of innovation. The redundancy introduced by channel coding in finite and real Galois fields is then related to over-sampling with similar reconstruction algorithms. The error locator polynomial (ELP) and iterative methods are shown to work quite effectively for both sampling and coding applications. The methods of Prony, Pisarenko, and MUltiple SIgnal Classification (MUSIC) are next shown to be targeted at analyzing signals with sparse frequency domain representations. Specifically, the relations of the approach of Prony to an annihilating filter in rate of innovation and ELP in coding are emphasized; the Pisarenko and MUSIC methods are further improvements of the Prony method under noisy environments. The iterative methods developed for sampling and coding applications are shown to be powerful tools in spectral estimation. Such narrowband spectral estimation is then related to multi-source location and direction of arrival estimation in array processing. Sparsity in unobservable source signals is also shown to facilitate source separation in sparse component analysis; the algorithms developed in this area such as linear programming and matching pursuit are also widely used in compressed sensing. Finally

  15. A unified multiwavelength model of galaxy formation

    NASA Astrophysics Data System (ADS)

    Lacey, Cedric G.; Baugh, Carlton M.; Frenk, Carlos S.; Benson, Andrew J.; Bower, Richard G.; Cole, Shaun; Gonzalez-Perez, Violeta; Helly, John C.; Lagos, Claudia D. P.; Mitchell, Peter D.

    2016-11-01

    We present a new version of the GALFORM semi-analytical model of galaxy formation. This brings together several previous developments of GALFORM into a single unified model, including a different initial mass function (IMF) in quiescent star formation and in starbursts, feedback from active galactic nuclei suppressing gas cooling in massive haloes, and a new empirical star formation law in galaxy discs based on their molecular gas content. In addition, we have updated the cosmology, introduced a more accurate treatment of dynamical friction acting on satellite galaxies, and updated the stellar population model. The new model is able to simultaneously explain both the observed evolution of the K-band luminosity function and stellar mass function, and the number counts and redshift distribution of sub-mm galaxies selected at 850 μm. This was not previously achieved by a single physical model within the Λcold dark matter framework, but requires having an IMF in starbursts that is somewhat top-heavy. The new model is tested against a wide variety of observational data covering wavelengths from the far-UV to sub-mm, and redshifts from z = 0 to 6, and is found to be generally successful. These observations include the optical and near-infrared (IR) luminosity functions, H I mass function, fraction of early type galaxies, Tully-Fisher, metallicity-luminosity and size-luminosity relations at z = 0, as well as far-IR number counts, and far-UV luminosity functions at z ˜ 3-6. Discrepancies are, however, found in galaxy sizes and metallicities at low luminosities, and in the abundance of low-mass galaxies at high-z, suggesting the need for a more sophisticated model of supernova feedback.

  16. Unified Model Deformation and Flow Transition Measurements

    NASA Technical Reports Server (NTRS)

    Burner, Alpheus W.; Liu, Tianshu; Garg, Sanjay; Bell, James H.; Morgan, Daniel G.

    1999-01-01

    The number of optical techniques that may potentially be used during a given wind tunnel test is continually growing. These include parameter sensitive paints that are sensitive to temperature or pressure, several different types of off-body and on-body flow visualization techniques, optical angle-of-attack (AoA), optical measurement of model deformation, optical techniques for determining density or velocity, and spectroscopic techniques for determining various flow field parameters. Often in the past the various optical techniques were developed independently of each other, with little or no consideration for other techniques that might also be used during a given test. Recently two optical techniques have been increasingly requested for production measurements in NASA wind tunnels. These are the video photogrammetric (or videogrammetric) technique for measuring model deformation known as the video model deformation (VMD) technique, and the parameter sensitive paints for making global pressure and temperature measurements. Considerations for, and initial attempts at, simultaneous measurements with the pressure sensitive paint (PSP) and the videogrammetric techniques have been implemented. Temperature sensitive paint (TSP) has been found to be useful for boundary-layer transition detection since turbulent boundary layers convect heat at higher rates than laminar boundary layers of comparable thickness. Transition is marked by a characteristic surface temperature change wherever there is a difference between model and flow temperatures. Recently, additional capabilities have been implemented in the target-tracking videogrammetric measurement system. These capabilities have permitted practical simultaneous measurements using parameter sensitive paint and video model deformation measurements that led to the first successful unified test with TSP for transition detection in a large production wind tunnel.

  17. From a Harmonious Unifying Hybrid Preferential Model Toward a Large Unifying Hybrid Network Model

    NASA Astrophysics Data System (ADS)

    Fang, Jinqing; Li, Yong; Bi, Qiao

    The motivation of this work raises four challenging questions: (1) Why is it that so many generalized random network models exist but they cannot be completely consistent with real-world networks? (2) Are these complex networks fundamentally attached in a random preferential manner without any deterministic attachment for both un-weighted and weighted networks? To answer the first two questions, we propose a harmonious unifying hybrid preferential model (HUHPM) controlled by a total hybrid ratio. (3) Why are social networks mostly positive degree-degree correlation but biological and technological networks tend to possess negative degree-degree correlation? (4) Are there coherent physical ideas and a unification formation mechanism for studies of complex networks? To seek a better answer of all these questions, especially the last two above, we extend the HUHPM to a large unifying hybrid network model (LUHNM), based on introducing two new hybrid ratios. We study the two models above, both numerically and analytically. All findings of topological properties in the network models above can give a certain universally meaningful result, which reveals some nontrivial topological properties, new phenomena, and give a relatively satisfactory answer.

  18. Disruption of the gene for Met-tRNA(fMet) formyltransferase severely impairs growth of Escherichia coli.

    PubMed Central

    Guillon, J M; Mechulam, Y; Schmitter, J M; Blanquet, S; Fayat, G

    1992-01-01

    In bacteria, as well as in chloroplasts and mitochondria, the free amino group of the methionylated initiator tRNA(fMet) is specifically modified by the addition of a formyl group. The importance of this modification remains unclear. With the availability of pure Escherichia coli 10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N-formyltransferase, the enzyme catalyzing Met-tRNA(fMet) formylation, the corresponding fmt gene and its flanking regions were cloned and sequenced. The chromosomal fmt gene was disrupted, and strains modified in their formylation activity were constructed. A depletion of the cellular formylation activity was accompanied by a decrease in the growth rate of the bacteria. At 37 degrees C, in a rich medium, the absence of a functional fmt gene reduced the growth rate to 0.28 doubling per h, from 2.3 for the control strain. At 42 degrees C, the studied fmt mutant strain did not grow further. PMID:1624424

  19. The School Office: An Overview.

    ERIC Educational Resources Information Center

    Hudson, Randy

    2000-01-01

    Presents an overview of the fundamental principles of school office design that remain constant despite changes in building technologies, and technological and spatial flexibility. Principles discussed include the school office and traffic patterns, security, and visitor reception requirements. (GR)

  20. The Mechanization of Office Work.

    ERIC Educational Resources Information Center

    Giuliano, Vincent E.

    1982-01-01

    Discusses how technology is changing the nature of office work by introducing new information-processing machines, programs for operating them, and communications systems for interconnecting them. Includes diagrams of preindustrial, industrial, and information-age offices. (Author/JN)

  1. NASA Parts Program Office responsibilities

    NASA Technical Reports Server (NTRS)

    Kilroy, Patrick L.

    1994-01-01

    The topics are presented in viewgraph form and include the following: NASA Parts Program Office responsibilities; NASA Parts Project Office responsibilities; development priorities; and candidate functions for EPIMS baseline.

  2. The Mechanization of Office Work.

    ERIC Educational Resources Information Center

    Giuliano, Vincent E.

    1982-01-01

    Discusses how technology is changing the nature of office work by introducing new information-processing machines, programs for operating them, and communications systems for interconnecting them. Includes diagrams of preindustrial, industrial, and information-age offices. (Author/JN)

  3. Army Officer Development: Historical Context

    DTIC Science & Technology

    2010-04-01

    its officers. The result was the landmark Review of Education and Training for Officers ( RETO ), a study that set the direction for the school system...and the officer development process for the rest of the Cold War and beyond. 37 The RETO report stressed the importance of officers mastering...the RETO recommendations for the War College’s curriculum with those of the earlier Haines Board brings their differences into stark relief. As noted

  4. Ergonomics in the office environment

    NASA Technical Reports Server (NTRS)

    Courtney, Theodore K.

    1993-01-01

    Perhaps the four most popular 'ergonomic' office culprits are: (1) the computer or visual display terminal (VDT); (2) the office chair; (3) the workstation; and (4) other automated equipment such as the facsimile machine, photocopier, etc. Among the ergonomics issues in the office environment are visual fatigue, musculoskeletal disorders, and radiation/electromagnetic (VLF,ELF) field exposure from VDT's. We address each of these in turn and then review some regulatory considerations regarding such stressors in the office and general industrial environment.

  5. Why Black Officers Still Fail

    DTIC Science & Technology

    2010-03-01

    White youth is smaller than it once was. They all pointed to the fact that today’s youth, both white and black, tend to be attracted to rap music and...papers touching on the experiences of black officers as they relate to representation, promotions, influence , and culture. They can best be...they relate to Black officer representation in the Army, Black officer promotion rates, Black officer influence on policy and decision making, black

  6. 29 CFR 779.218 - Methods to accomplish “unified operation.”

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 3 2012-07-01 2012-07-01 false Methods to accomplish âunified operation.â 779.218 Section... Coverage Unified Operation Or Common Control § 779.218 Methods to accomplish “unified operation.” There are... case the activities are performed through “unified operation” and have the effect of creating a...

  7. 29 CFR 779.218 - Methods to accomplish “unified operation.”

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Methods to accomplish âunified operation.â 779.218 Section... Coverage Unified Operation Or Common Control § 779.218 Methods to accomplish “unified operation.” There are... case the activities are performed through “unified operation” and have the effect of creating a...

  8. 29 CFR 779.218 - Methods to accomplish “unified operation.”

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 3 2011-07-01 2011-07-01 false Methods to accomplish âunified operation.â 779.218 Section... Coverage Unified Operation Or Common Control § 779.218 Methods to accomplish “unified operation.” There are... case the activities are performed through “unified operation” and have the effect of creating a...

  9. 29 CFR 779.218 - Methods to accomplish “unified operation.”

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 3 2014-07-01 2014-07-01 false Methods to accomplish âunified operation.â 779.218 Section... Coverage Unified Operation Or Common Control § 779.218 Methods to accomplish “unified operation.” There are... case the activities are performed through “unified operation” and have the effect of creating a...

  10. 29 CFR 779.218 - Methods to accomplish “unified operation.”

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 3 2013-07-01 2013-07-01 false Methods to accomplish âunified operation.â 779.218 Section... Coverage Unified Operation Or Common Control § 779.218 Methods to accomplish “unified operation.” There are... case the activities are performed through “unified operation” and have the effect of creating a...

  11. Office Workers Stress Survey Results.

    ERIC Educational Resources Information Center

    North Carolina Occupational Safety and Health Project, Durham.

    A survey of office workers employed by North Carolina telephone companies was conducted to determine the extent and types of health problems experienced by office workers who use video display terminals (VDTs). Data were gathered by questionnaires mailed to 2,478 office workers, with 966 responses. Questions concerning a wide range of health…

  12. Is the Office Hour Obsolete?

    ERIC Educational Resources Information Center

    Behrens, Susan

    2013-01-01

    A colleague can't make a coffee date at a time the author proposes because it would conflict with his office hour. No student has actually made an appointment with him during the hour, but he is committed to being in his office as promised in case someone drops by. The author's reaction to her colleague's faithfulness to his posted office hour…

  13. Michael Griffin Oath Of Office

    NASA Image and Video Library

    2005-04-14

    NASA Administrator Michael Griffin, left, is administered the oath of office by John H. Marburger, right, Science Adviser to the President and Office of Science and Technology Policy Director, during a private ceremony at the Old Executive Office Building, Thursday, April 14, 2005, in Washington, while his wife Rebecca and daughter Katie look on. Photo Credit: (NASA/Renee Bouchard)

  14. Is the Office Hour Obsolete?

    ERIC Educational Resources Information Center

    Behrens, Susan

    2013-01-01

    A colleague can't make a coffee date at a time the author proposes because it would conflict with his office hour. No student has actually made an appointment with him during the hour, but he is committed to being in his office as promised in case someone drops by. The author's reaction to her colleague's faithfulness to his posted office hour…

  15. VIDEO: Dr. Henry Rodriguez - Proteogenomics in Cancer Medicine | Office of Cancer Clinical Proteomics Research

    Cancer.gov

    Dr. Henry Rodriguez, director of the Office of Cancer Clinical Proteomics Research (OCCPR) at NCI, speaks with ecancer television at WIN 2017 about the translation of the proteins expressed in a patient's tumor into a map for druggable targets. By combining genomic and proteomic information (proteogenomics), leading scientists are gaining new insights into ways to detect and treat cancer due to a more complete and unified understanding of complex biological processes.

  16. Mars MetNet Mission - Martian Atmospheric Observational Post Network

    NASA Astrophysics Data System (ADS)

    Haukka, Harri; Harri, Ari-Matti; Aleksashkin, Sergey; Arruego, Ignacio; Schmidt, Walter; Genzer, Maria; Vazquez, Luis; Siikonen, Timo; Palin, Matti

    2016-10-01

    A new kind of planetary exploration mission for Mars is under development in collaboration between the Finnish Meteorological Institute (FMI), Lavochkin Association (LA), Space Research Institute (IKI) and Institutio Nacional de Tecnica Aerospacial (INTA). The Mars MetNet mission is based on a new semi-hard landing vehicle called MetNet Lander (MNL).The scientific payload of the Mars MetNet Precursor mission is divided into three categories: Atmospheric instruments, Optical devices and Composition and structure devices. Each of the payload instruments will provide significant insights in to the Martian atmospheric behavior.The key technologies of the MetNet Lander have been qualified and the electrical qualification model (EQM) of the payload bay has been built and successfully tested.Full Qualification Model (QM) of the MetNet landing unit with the Precursor Mission payload is currently under functional tests. In the near future the QM unit will be exposed to environmental tests with qualification levels including vibrations, thermal balance, thermal cycling and mechanical impact shock. One complete flight unit of the entry, descent and landing systems (EDLS) has been manufactured and tested with acceptance levels. Another flight-like EDLS has been exposed to most of the qualification tests, and hence it may be used for flight after refurbishments. Accordingly two flight-capable EDLS systems exist. The eventual goal is to create a network of atmospheric observational posts around the Martian surface. The next step in the MetNet Precursor Mission is the demonstration of the technical robustness and scientific capabilities of the MetNet type of landing vehicle. Definition of the Precursor Mission and discussions on launch opportunities are currently under way. The baseline program development funding exists for the next five years. Flight unit manufacture of the payload bay takes about 18 months, and it will be commenced after the Precursor Mission has been defined.

  17. Leasing physician office space.

    PubMed

    Murray, Charles

    2009-01-01

    When leasing office space, physicians should determine the effective lease rate (ELR) for each building they are considering before making a selection. The ELR is based on a number of factors, including building quality, building location, basic form of lease agreement, rent escalators and add-on factors in the lease, tenant improvement allowance, method of square footage measurement, quality of building management, and other variables. The ELR enables prospective physician tenants to accurately compare lease rates being quoted by building owners and to make leasing decisions based on objective criteria.

  18. Aviation Officer Requirements Study.

    DTIC Science & Technology

    1982-08-31

    In the dynamics of the planning process, when potential force level changes are fre- quent, these computations are tedious and subject to error . Since...was tedious and subject to both computational and entry errors . The current ver- sion of the model corrects this deficiency. The Aviation Officer...k.N )) ,iFY(Fr\\) ,NniALT c nTn ,TIVP.W £-430 PROJ3 = POS-:(PRn1 Z=m4m) f-440 PROC, = Pnr3(PrOnf2="-) E.4! - INI T (1-F(20) )TR(PrOFL,. 137> C,460 = TIPO

  19. Assessing peak aerobic capacity in Dutch law enforcement officers.

    PubMed

    Wittink, Harriet; Takken, Tim; de Groot, Janke; Reneman, Michiel; Peters, Roelof; Vanhees, Luc

    2015-01-01

    To cross-validate the existing peak rate of oxygen consumption (VO2peak) prediction equations in Dutch law enforcement officers and to determine whether these prediction equations can be used to predict VO2peak for groups and in a single individual. A further objective was to report normative absolute and relative VO2peak values of a sample of law enforcement officers in the Netherlands. The peak rate of oxygen consumption (ml×kg-1×min-1) was measured using a maximal incremental bicycle test in 1530 subjects, including 1068 male and 461 female police officers. Validity of the prediction equations for groups was assessed by comparing predicted VO2peak with measured VO2peak using paired t-tests. For individual differences limits of agreement (LoA) were calculated. Equations were considered valid for individuals when the difference between measured and predicted VO2peak did not exceed ±1 metabolic equivalent (MET) in 95% of individuals. None of the equations met the validity criterion of 95% of individuals having ±1 MET difference or less than the measured value. Limits of agreement (LoAs) were large in all predictions. At the individual level, none of the equations were valid predictors of VO2peak (ml×kg-1×min-1). Normative values for Dutch law enforcement officers were presented. Substantial differences between measured and predicted VO2peak (ml×kg-1×min-1) were found. Most tested equations were invalid predictors of VO2peak at group level and all were invalid at individual levels. This work is available in Open Access model and licensed under a CC BY-NC 3.0 PL license.

  20. MET Gene Amplification and MET Receptor Activation Are Not Sufficient to Predict Efficacy of Combined MET and EGFR Inhibitors in EGFR TKI-Resistant NSCLC Cells

    PubMed Central

    Presutti, Dario; Santini, Simonetta; Cardinali, Beatrice; Papoff, Giuliana; Lalli, Cristiana; Samperna, Simone; Fustaino, Valentina; Giannini, Giuseppe; Ruberti, Giovina

    2015-01-01

    Epidermal growth factor receptor (EGFR), member of the human epidermal growth factor receptor (HER) family, plays a critical role in regulating multiple cellular processes including proliferation, differentiation, cell migration and cell survival. Deregulation of the EGFR signaling has been found to be associated with the development of a variety of human malignancies including lung, breast, and ovarian cancers, making inhibition of EGFR the most promising molecular targeted therapy developed in the past decade against cancer. Human non small cell lung cancers (NSCLC) with activating mutations in the EGFR gene frequently experience significant tumor regression when treated with EGFR tyrosine kinase inhibitors (TKIs), although acquired resistance invariably develops. Resistance to TKI treatments has been associated to secondary mutations in the EGFR gene or to activation of additional bypass signaling pathways including the ones mediated by receptor tyrosine kinases, Fas receptor and NF-kB. In more than 30–40% of cases, however, the mechanisms underpinning drug-resistance are still unknown. The establishment of cellular and mouse models can facilitate the unveiling of mechanisms leading to drug-resistance and the development or validation of novel therapeutic strategies aimed at overcoming resistance and enhancing outcomes in NSCLC patients. Here we describe the establishment and characterization of EGFR TKI-resistant NSCLC cell lines and a pilot study on the effects of a combined MET and EGFR inhibitors treatment. The characterization of the erlotinib-resistant cell lines confirmed the association of EGFR TKI resistance with loss of EGFR gene amplification and/or AXL overexpression and/or MET gene amplification and MET receptor activation. These cellular models can be instrumental to further investigate the signaling pathways associated to EGFR TKI-resistance. Finally the drugs combination pilot study shows that MET gene amplification and MET receptor activation

  1. Cardio-Kidney-Damage: a unifying concept.

    PubMed

    El Nahas, Meguid

    2010-07-01

    The perceived global rise in chronic kidney disease (CKD) has been met with apprehension and skepticism. It has been argued by some that we are facing a CKD 'epidemic' and by others that the high prevalence of CKD observed in different communities may be the result of flawed screening methods and tools. Both estimation of glomerular filtration rate and determination of microalbuminuria as markers of CKD have been criticized. Also, many commented that CKD, as currently defined, was primarily a disease of elderly people with reduced kidney function. Some described this as a physiological age-related decline in kidney function while others consider it to be pathological, warranting the label of a disease. In this review, an attempt is made to reconcile different views by examining some of the available evidence and to conclude that the high prevalence of 'CKD' in the elderly population is likely to reflect the underlying high prevalence of overt and subclinical atherosclerosis and cardiovascular disease. This leads to the conclusion that CKD is a reflection of diffuse and age-related Cardio-Kidney-Damage (C-K-D) that may not warrant the label of disease but certainly justifies attention with reduction of lifelong cardiovascular risks and careful evaluation and treatment.

  2. MET and AKT Genetic Influence on Facial Emotion Perception

    PubMed Central

    Huang, Chieh-Liang; Huang, Yu-Jhen; Tsai, Guochuan E.; Lane, Hsien-Yuan

    2012-01-01

    Background Facial emotion perception is a major social skill, but its molecular signal pathway remains unclear. The MET/AKT cascade affects neurodevelopment in general populations and face recognition in patients with autism. This study explores the possible role of MET/AKT cascade in facial emotion perception. Methods One hundred and eighty two unrelated healthy volunteers (82 men and 100 women) were recruited. Four single nucleotide polymorphisms (SNP) of MET (rs2237717, rs41735, rs42336, and rs1858830) and AKT rs1130233 were genotyped and tested for their effects on facial emotion perception. Facial emotion perception was assessed by the face task of Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT). Thorough neurocognitive functions were also assessed. Results Regarding MET rs2237717, individuals with the CT genotype performed better in facial emotion perception than those with TT (p = 0.016 by ANOVA, 0.018 by general linear regression model [GLM] to control for age, gender, and education duration), and showed no difference with those with CC. Carriers with the most common MET CGA haplotype (frequency = 50.5%) performed better than non-carriers of CGA in facial emotion perception (p = 0.018, df = 1, F = 5.69, p = 0.009 by GLM). In MET rs2237717/AKT rs1130233 interaction, the C carrier/G carrier group showed better facial emotion perception than those with the TT/AA genotype (p = 0.035 by ANOVA, 0.015 by GLM), even when neurocognitive functions were controlled (p = 0.046 by GLM). Conclusions To our knowledge, this is the first study to suggest that genetic factors can affect performance of facial emotion perception. The findings indicate that MET variances and MET/AKT interaction may affect facial emotion perception, implicating that the MET/AKT cascade plays a significant role in facial emotion perception. Further replication studies are needed. PMID:22558359

  3. Unifying plant molecular data and plants.

    PubMed

    Jacobsen, N; Orgaard, M

    1996-01-01

    Located at a botanical department at an Agricultural University, our taxonomical and genetic research is mainly directed towards cultivated plants and their wild relatives. The investigations are usually under a common heading 'experimental taxonomy', and include basic systematics, cytogenetics, biodiversity, population dynamics, conservation and evolutionary questions correlating the wild species and the cultivated forms. Our point of initiation is the plants and questions/problems raised regarding these plants. Our way of approaching the problems is usually by applying different sets of data and testing them. Experimental taxonomy covers classical cytogenetics (chromosome counting and karyotyping) as well as molecular cytogenetic methods (RAPD, RFLP, in situ hybridization), and includes also chemical data on isoenzymes and anthocyanins. We have had good collaborations with other laboratories and found their expertise on the plants in question very helpful. The aim is always to unify various data on the same set of problems, in order to get a more complete understanding of the plants. At present the department is working on several, quite different plant genera, comprising herbs, aquatic plants, and trees. The methods vary, depending on the plants and the problems in question. Some of the current investigations concern the horticultural genera Lilium and Crocus, in which the main point of interest is the study of chromosome evolution using fluorescence in situ hybridization; preliminary investigations into the composition of anthocyanins in Crocus look very promising. In the tropical starch tuber crop Pachyrhizus (Fabaceae), molecular analyses of relationships between existing cultivars, landraces and wild material have been carried out. A genus which we, in cooperation with a number of other laboratories, have been working with for many years is Hordeum (Poaceae) with one cultivated species (barley) and 31 wild species. Here the main areas of investigation have

  4. SCEC UCVM - Unified California Velocity Model

    NASA Astrophysics Data System (ADS)

    Small, P.; Maechling, P. J.; Jordan, T. H.; Ely, G. P.; Taborda, R.

    2011-12-01

    The SCEC Unified California Velocity Model (UCVM) is a software framework for a state-wide California velocity model. UCVM provides researchers with two new capabilities: (1) the ability to query Vp, Vs, and density from any standard regional California velocity model through a uniform interface, and (2) the ability to combine multiple velocity models into a single state-wide model. These features are crucial in order to support large-scale ground motion simulations and to facilitate improvements in the underlying velocity models. UCVM provides integrated support for the following standard velocity models: SCEC CVM-H, SCEC CVM-S and the CVM-SI variant, USGS Bay Area (cencalvm), Lin-Thurber Statewide, and other smaller regional models. New models may be easily incorporated as they become available. Two query interfaces are provided: a Linux command line program, and a C application programming interface (API). The C API query interface is simple, fully independent of any specific model, and MPI-friendly. Input coordinates are geographic longitude/latitude and the vertical coordinate may be either depth or elevation. Output parameters include Vp, Vs, and density along with the identity of the model from which these material properties were obtained. In addition to access to the standard models, UCVM also includes a high resolution statewide digital elevation model, Vs30 map, and an optional near-surface geo-technical layer (GTL) based on Ely's Vs30-derived GTL. The elevation and Vs30 information is bundled along with the returned Vp,Vs velocities and density, so that all relevant information is retrieved with a single query. When the GTL is enabled, it is blended with the underlying crustal velocity models along a configurable transition depth range with an interpolation function. Multiple, possibly overlapping, regional velocity models may be combined together into a single state-wide model. This is accomplished by tiling the regional models on top of one another in

  5. Photodissociation of metallo-carbohedrene (met-cars) cluster cations

    SciTech Connect

    Pilgrim, J.S.; Duncan, M.A. )

    1993-05-19

    Castleman and co-workers have recently reported the formation of especially stable metal-carbon clusters designated [open quotes]metallo-carbohedrenes[close quotes], or [open quotes]met-cars[close quotes]. In their work, metal-carbon mixed clusters having the formula M[sub 8]C[sub 12] form preferentially from plasmas containing a carbon precursor and transition metals (e.g., Ti[sub 8]C[sub 12]). We report here the first mass-selected photo-dissociation experiments on met-cars clusters. These experiments reveal the decomposition mechanism of these species and provide new insight into their bonding and stabilities. These photodissociation experiments indicate that there are at least two general mechanisms important in met-cars cluster decomposition, metal atom elimination and M-C[sub 2] elimination. Chromium and iron met-cars clusters are suggested to be less stable overall than titanium and vanadium systems, while the M-C[sub 2] interactions are suggested to be especially strong for zirconium met-cars cluster. 10 refs., 1 fig.

  6. MetAmyl: A METa-Predictor for AMYLoid Proteins

    PubMed Central

    Emily, Mathieu; Talvas, Anthony; Delamarche, Christian

    2013-01-01

    The aggregation of proteins or peptides in amyloid fibrils is associated with a number of clinical disorders, including Alzheimer's, Huntington's and prion diseases, medullary thyroid cancer, renal and cardiac amyloidosis. Despite extensive studies, the molecular mechanisms underlying the initiation of fibril formation remain largely unknown. Several lines of evidence revealed that short amino-acid segments (hot spots), located in amyloid precursor proteins act as seeds for fibril elongation. Therefore, hot spots are potential targets for diagnostic/therapeutic applications, and a current challenge in bioinformatics is the development of methods to accurately predict hot spots from protein sequences. In this paper, we combined existing methods into a meta-predictor for hot spots prediction, called MetAmyl for METapredictor for AMYLoid proteins. MetAmyl is based on a logistic regression model that aims at weighting predictions from a set of popular algorithms, statistically selected as being the most informative and complementary predictors. We evaluated the performances of MetAmyl through a large scale comparative study based on three independent datasets and thus demonstrated its ability to differentiate between amyloidogenic and non-amyloidogenic polypeptides. Compared to 9 other methods, MetAmyl provides significant improvement in prediction on studied datasets. We further show that MetAmyl is efficient to highlight the effect of point mutations involved in human amyloidosis, so we suggest this program should be a useful complementary tool for the diagnosis of these diseases. PMID:24260292

  7. Sequential EMT-MET induces neuronal conversion through Sox2.

    PubMed

    He, Songwei; Chen, Jinlong; Zhang, Yixin; Zhang, Mengdan; Yang, Xiao; Li, Yuan; Sun, Hao; Lin, Lilong; Fan, Ke; Liang, Lining; Feng, Chengqian; Wang, Fuhui; Zhang, Xiao; Guo, Yiping; Pei, Duanqing; Zheng, Hui

    2017-01-01

    Direct neuronal conversion can be achieved with combinations of small-molecule compounds and growth factors. Here, by studying the first or induction phase of the neuronal conversion induced by defined 5C medium, we show that the Sox2-mediated switch from early epithelial-mesenchymal transition (EMT) to late mesenchymal-epithelial transition (MET) within a high proliferation context is essential and sufficient for the conversion from mouse embryonic fibroblasts (MEFs) to TuJ(+) cells. At the early stage, insulin and basic fibroblast growth factor (bFGF)-induced cell proliferation, early EMT, the up-regulation of Stat3 and Sox2, and the subsequent activation of neuron projection. Up-regulated Sox2 then induced MET and directed cells towards a neuronal fate at the late stage. Inhibiting either stage of this sequential EMT-MET impaired the conversion. In addition, Sox2 could replace sequential EMT-MET to induce a similar conversion within a high proliferation context, and its functions were confirmed with other neuronal conversion protocols and MEFs reprogramming. Therefore, the critical roles of the sequential EMT-MET were implicated in direct cell fate conversion in addition to reprogramming, embryonic development and cancer progression.

  8. "Active" cancer immunotherapy by anti-Met antibody gene transfer.

    PubMed

    Vigna, Elisa; Pacchiana, Giovanni; Mazzone, Massimiliano; Chiriaco, Cristina; Fontani, Lara; Basilico, Cristina; Pennacchietti, Selma; Comoglio, Paolo M

    2008-11-15

    Gene therapy provides a still poorly explored opportunity to treat cancer by "active" immunotherapy as it enables the transfer of genes encoding antibodies directed against specific oncogenic proteins. By a bidirectional lentiviral vector, we transferred the cDNA encoding the heavy and light chains of a monoclonal anti-Met antibody (DN-30) to epithelial cancer cells. In vitro, the transduced cells synthesized and secreted correctly assembled antibodies with the expected high affinity, inducing down-regulation of the Met receptor and strong inhibition of the invasive growth response. The inhibitory activity resulted (a) from the interference of the antibody with the Met receptor intracellular processing ("cell autonomous activity," in cis) and (b) from the antibody-induced cleavage of Met expressed at the cell surface ("bystander effect," in trans). The monoclonal antibody gene transferred into live animals by systemic administration or by local intratumor delivery resulted in substantial inhibition of tumor growth. These data provide proof of concept both for targeting the Met receptor and for a gene transfer-based immunotherapy strategy.

  9. Novel interaction partners of the TPR/MET tyrosine kinase.

    PubMed

    Schaaf, Christian P; Benzing, Jörg; Schmitt, Thomas; Erz, Dorothee H R; Tewes, Magdalena; Bartram, Claus R; Janssen, Johannes W G

    2005-02-01

    A large variety of biological processes is mediated by stimulation of the receptor tyrosine kinase MET. Screening a mouse embryo cDNA library, we were able to identify several novel, putative intracellular TPR/MET-substrates: SNAPIN, DCOHM, VAV-1, Sorting nexin 2, Death associated protein kinase 3, SMC-1, Centromeric protein C, and hTID-1. Interactions as identified by yeast two-hybrid analysis were validated in vitro and in vivo by mammalian two-hybrid studies, a far-western assay and coimmunoprecipitation. Participation in apoptosis-regulating mechanisms through interaction with DAPK-3 and cell cycle control via binding to nuclear proteins such as CENPC and SMC-1 are possible new aspects of intracellular MET signaling.

  10. Adsorption of methane molecules on neutral titanium Met-Cars

    SciTech Connect

    Sakurai, H.; Castleman, A.W. Jr.

    1999-07-01

    Titanium metallocarbohedrenes (Met-Cars) are observed to adsorb methane molecules at low temperatures. The observed formation of the methane-Ti{sub 8}C{sub 12} cluster complexes provides further direct evidence establishing that stable {ital neutral} titanium Met-Cars are present in copious amounts in the cluster beam. At sufficiently low temperatures, a dominant peak is observed for Ti{sub 8}C{sub 12}(CH{sub 4}){sub 4} along with less intense peaks of other methane-Ti{sub 8}C{sub 12} clusters, which suggests the geometry of titanium Met-Cars may be the tetrahedral cage structure with T{sub d} symmetry. By studying the photoionization efficiency of the methane-Ti{sub 8}C{sub 12} complexes near ionization threshold, their ionization potentials are found to be lower than that of Ti{sub 8}C{sub 12}. {copyright} {ital 1999 American Institute of Physics.}

  11. BacMet: antibacterial biocide and metal resistance genes database

    PubMed Central

    Pal, Chandan; Bengtsson-Palme, Johan; Rensing, Christopher; Kristiansson, Erik; Larsson, D. G. Joakim

    2014-01-01

    Antibiotic resistance has become a major human health concern due to widespread use, misuse and overuse of antibiotics. In addition to antibiotics, antibacterial biocides and metals can contribute to the development and maintenance of antibiotic resistance in bacterial communities through co-selection. Information on metal and biocide resistance genes, including their sequences and molecular functions, is, however, scattered. Here, we introduce BacMet (http://bacmet.biomedicine.gu.se)—a manually curated database of antibacterial biocide- and metal-resistance genes based on an in-depth review of the scientific literature. The BacMet database contains 470 experimentally verified resistance genes. In addition, the database also contains 25 477 potential resistance genes collected from public sequence repositories. All resistance genes in the BacMet database have been organized according to their molecular function and induced resistance phenotype. PMID:24304895

  12. Past and future corollaries of theories on causes of metabolic syndrome and obesity related co-morbidities part 2: a composite unifying theory review of human-specific co-adaptations to brain energy consumption.

    PubMed

    McGill, Anne-Thea

    2014-01-01

    Metabolic syndrome (MetS) predicts type II diabetes mellitus (TIIDM), cardiovascular disease (CVD) and cancer, and their rates have escalated over the last few decades. Obesity related co-morbidities also overlap the concept of the metabolic syndrome (MetS). However, understanding of the syndrome's underlying causes may have been misapprehended. The current paper follows on from a theory review by McGill, A-T in Archives of Public Health, 72: 30. This accompanying paper utilises research on human evolution and new biochemistry to theorise on why MetS and obesity arise and how they affect the population. The basis of this composite unifying theory is that the proportionately large, energy-demanding human brain may have driven co-adaptive mechanisms to provide, or conserve, energy for the brain. A 'dual system' is proposed. 1) The enlarged, complex cortico-limbic-striatal system increases dietary energy by developing strong neural self-reward/motivation pathways for the acquisition of energy dense food, and (2) the nuclear factor-erythroid 2-related factor 2 (NRF2) cellular protection system amplifies antioxidant, antitoxicant and repair activity by employing plant chemicals. In humans who consume a nutritious diet, the NRF2 system has become highly energy efficient. Other relevant human-specific co-adaptations are explored. In order to 'test' this composite unifying theory it is important to show that the hypothesis and sub-theories pertain throughout the whole of human evolution and history up till the current era. Corollaries of the composite unifying theory of MetS are examined with respect to past under-nutrition and malnutrition since agriculture began 10,000 years ago. The effects of man-made pollutants on degenerative change are examined. Projections are then made from current to future patterns on the state of 'insufficient micronutrient and/or unbalanced high energy malnutrition with central obesity and metabolic dysregulation' or 'malnubesity'. Forecasts

  13. Remembering the early days of the Met Lab

    SciTech Connect

    Katz, J.J.

    1990-01-01

    The Met Lab was set up by the war-time Manhattan District, US Corp of Engineers to (i) find a system using normal uranium in which a chain reaction would occur; (ii) to show that if such a chain reaction did occur, it would be possible to separate plutonium chemically from the uranium matrix and the fission products formed in the chain reactions; and (iii) to prepare plans for the large-scale production of plutonium. Chemistry Section C-1 of the Met Lab was assigned the responsibility for developing separation methods for plutonium production on the industrial scale. This report describes some aspects of daily life in Section C-1.

  14. EMT and MET as paradigms for cell fate switching.

    PubMed

    Chen, Jiekai; Han, Qingkai; Pei, Duanqing

    2012-04-01

    Cell fate determination is a major unsolved problem in cell and developmental biology. The discovery of reprogramming by pluripotent factors offers a rational system to investigate the molecular mechanisms associated with cell fate decisions. The idea that reprogramming of fibroblasts starts with a mesenchymal-epithelial transition (MET) suggests that the process is perhaps a reversal of epithelial to mesenchymal transition (EMT) found frequently during early embryogenesis. As such, we believe that investigations into MET-EMT may yield detailed molecular insights into cell fate decisions, not only for the switching between epithelial and mesenchymal cells, but also other cell types.

  15. The MetOp satellite - Weather information from polar orbit

    NASA Astrophysics Data System (ADS)

    Edwards, Peter G.; Berutti, Bruno; Blythe, Paul; Callies, Joerg; Carlier, Stefane; Fransen, Cees; Krutsch, Rainer; Lefebvre, Alain-Robert; Loiselet, Marc; Stricker, Nico

    2006-08-01

    MetOp-A is Europe's first polar-orbiting satellite dedicated to operational meteorology. With its array of advanced instruments, it will provide data of unprecedented accuracy and resolution on temperature and humidity, wind speed and direction over the ocean, and ozone and other trace gases, making a huge contribution to global weather forecasting and climate monitoring. In addition, MetOp-A will observe land and ocean surfaces and its search-and-rescue service will help ships and aircraft in distress.

  16. INEL Sample Management Office

    SciTech Connect

    Watkins, C.

    1994-12-31

    The Idaho National Engineering Laboratory (INEL) Sample Management Office (SMO) was formed as part of the EG&G Idaho Environmental Restoration Program (ERP) in June, 1990. Since then, the SMO has been recognized and sought out by other prime contractors and programs at the INEL. Since December 1991, the DOE-ID Division Directors for the Environmental Restoration Division and Waste Management Division supported the expansion of the INEL ERP SMO into the INEL site wide SMO. The INEL SMO serves as a point of contact for multiple environmental analytical chemistry and laboratory issues (e.g., capacity, capability). The SMO chemists work with project managers during planning to help develop data quality objectives, select appropriate analytical methods, identify special analytical services needs, identify a source for the services, and ensure that requirements for sampling and analysis (e.g., preservations, sample volumes) are clear and technically accurate. The SMO chemists also prepare work scope statements for the laboratories performing the analyses.

  17. Badge Office Process Analysis

    SciTech Connect

    Haurykiewicz, John Paul; Dinehart, Timothy Grant; Parker, Robert Young

    2016-05-12

    The purpose of this process analysis was to analyze the Badge Offices’ current processes from a systems perspective and consider ways of pursuing objectives set forth by SEC-PS, namely increased customer flow (throughput) and reduced customer wait times. Information for the analysis was gathered for the project primarily through Badge Office Subject Matter Experts (SMEs), and in-person observation of prevailing processes. Using the information gathered, a process simulation model was constructed to represent current operations and allow assessment of potential process changes relative to factors mentioned previously. The overall purpose of the analysis was to provide SEC-PS management with information and recommendations to serve as a basis for additional focused study and areas for potential process improvements in the future.

  18. The Eleventh Summative Report of the Office of Computer-Based Instruction.

    ERIC Educational Resources Information Center

    Hofstetter, Fred T.

    The University of Delaware's work with computer-based instruction since 1974 is summarized with attention to the history and development of the Office of Computer-Based Instruction, university applications, outside user applications, and research and evaluation. PLATO was the system that met the university's criteria, which included support for…

  19. The chief strategy officer.

    PubMed

    Breene, R Timothy S; Nunes, Paul F; Shill, Walter E

    2007-10-01

    They're nominally and ultimately responsible for strategy, but today's CEOs have less and less time to devote to it. As a result, CEOs are appointing "chief strategy officers"--executives specifically tasked with creating, communicating, executing, and sustaining a company's strategic initiatives. In this article, three authors from Accenture share the results of their research on this emerging organizational role. The typical CSO or top strategy executive is not a pure strategist, conducting long-range planning in relative isolation. Most CSOs consider themselves doers first, with the mandate, credentials, and desire to act as well as advise. They are seasoned executives with a strong strategy orientation who have usually worn many operations hats before taking on the role. Strategy executives are charged with three critical jobs that together form the very definition of strategy execution. First, they must clarify the company's strategy for themselves and for every business unit and function, ensuring that all employees understand the details of the strategic plan and how their work connects to corporate goals. Second, CSOs must drive immediate change. The focus of the job almost always quickly evolves from creating shared alignment around a vision to riding herd on the ensuing change effort. Finally, a CSO must drive decision making that sustains organizational change. He or she must be that person who, in the CEO's stead, can walk into any office and test whether the decisions being made are aligned with the strategy and are creating the desired results. When decisions below the executive suite aren't being made in accordance with strategy, much of the CSO's job involves learning why and quickly determining whether to stay the course or change tack.

  20. Physician offices marketing: assessing patients' views of office visits.

    PubMed

    Emmett, Dennis; Chandra, Ashish

    2010-01-01

    Physician offices often lack the sense of incorporating appropriate strategies to make their facilities as marketer of their services. The patient experience at a physician's office not only incorporates the care they receive from the physician but also the other non-healthcare related aspects, such as the behavior of non-health professionals as well as the appearance of the facility itself. This paper is based on a primary research conducted to assess what patients assess from a physician office visit.

  1. 75 FR 2549 - Office of Biotechnology Activities; Office of Science Policy; Office of the Director; Notice of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-15

    ... HUMAN SERVICES National Institutes of Health Office of Biotechnology Activities; Office of Science... concerning this meeting, contact Ms. Laurie Lewallen, Advisory Committee Coordinator, Office of Biotechnology...: January 11, 2010. Kelly R. Fennington, Special Assistant to the Director, Office of Biotechnology...

  2. 76 FR 77240 - Office of Biotechnology Activities, Office of Science Policy, Office of the Director; Notice of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Office of Biotechnology Activities, Office of Science..., NIH Office of Biotechnology Activities, 6705 Rockledge Drive, Suite 750, Bethesda, Maryland 20892...

  3. Nothing From Everything- A Unified Theory

    NASA Astrophysics Data System (ADS)

    Mehra, Vijay Kumar

    2016-07-01

    Nothing From Everything-A Unified Theory is a philosophical insight into principles of nature through principle of complementary spontaneity and principle of vertical continuity. This work is intended to explain various cosmological phenomena in light of behaviour of particles in range of their respective and relative speed of light. This theory explains creation of Universe from nothing or zero spacetime through scalar energy field collapsing into Higgs field resulting into giving mass to various particles. The energy particles taking origin from nothing while moving away from zero space-time would create space-time of their own order because energy/matter needs space to exist. The particles while moving away from zero space-time would end up in breaking symmetry of matter/energy at their mass infinity (highest possible mass of any particle, which is function of speed of spin). This break in symmetry would lead to curving of particles upon themselves and hence would lead to creation of antiparticles going back in time towards zero spacetime. Therefore the Universe could have been created by alternate layers of particles and antiparticles and also alternate layers of matter and antimatter with decelerating speed of light, which would lead to creation a closed and flat Universe. With increase in mass of Universe (creation of more and more Universe's matter from nothing), the gravitational force of Universe is bound to increase and hence with quantum by quantum increase in gravity, it would apply brakes on relative speed of photon/light out of its reference frame or designated space and hence speed of photon would decrease. If closed and flat Universe was created with decelerating speed of light, then such Universe is bound to contract back with accelerating speed of light which would have inverse impact on gravitational constant across various spacetime zones of Universe. And hence mass bodies would drift away spontaneously purely on basis and proportional to

  4. Operational Numerical Weather Prediction at the Met Office and potential ways forward for operational space weather prediction systems

    NASA Astrophysics Data System (ADS)

    Jackson, David

    NICT (National Institute of Information and Communications Technology) has been in charge of space weather forecast service in Japan for more than 20 years. The main target region of the space weather is the geo-space in the vicinity of the Earth where human activities are dominant. In the geo-space, serious damages of satellites, international space stations and astronauts take place caused by energetic particles or electromagnetic disturbances: the origin of the causes is dynamically changing of solar activities. Positioning systems via GPS satellites are also im-portant recently. Since the most significant effect of positioning error comes from disturbances of the ionosphere, it is crucial to estimate time-dependent modulation of the electron density profiles in the ionosphere. NICT is one of the 13 members of the ISES (International Space Environment Service), which is an international assembly of space weather forecast centers under the UNESCO. With help of geo-space environment data exchanging among the member nations, NICT operates daily space weather forecast service every day to provide informa-tion on forecasts of solar flare, geomagnetic disturbances, solar proton event, and radio-wave propagation conditions in the ionosphere. The space weather forecast at NICT is conducted based on the three methodologies: observations, simulations and informatics (OSI model). For real-time or quasi real-time reporting of space weather, we conduct our original observations: Hiraiso solar observatory to monitor the solar activity (solar flare, coronal mass ejection, and so on), domestic ionosonde network, magnetometer HF radar observations in far-east Siberia, and south-east Asia low-latitude ionosonde network (SEALION). Real-time observation data to monitor solar and solar-wind activities are obtained through antennae at NICT from ACE and STEREO satellites. We have a middle-class super-computer (NEC SX-8R) to maintain real-time computer simulations for solar and solar-wind, magnetosphere and ionosphere. The three simulations are directly or indirectly connected each other based on real-time observa-tion data to reproduce a virtual geo-space region on the super-computer. Informatics is a new methodology to make precise forecast of space weather. Based on new information and communication technologies (ICT), it provides more information in both quality and quantity. At NICT, we have been developing a cloud-computing system named "space weather cloud" based on a high-speed network system (JGN2+). Huge-scale distributed storage (1PB), clus-ter computers, visualization systems and other resources are expected to derive new findings and services of space weather forecasting. The final goal of NICT space weather service is to predict near-future space weather conditions and disturbances which will be causes of satellite malfunctions, tele-communication problems, and error of GPS navigations. In the present talk, we introduce our recent activities on the space weather services and discuss how we are going to develop the services from the view points of space science and practical uses.

  5. A novel unified coding analytical method for Internet of Things

    NASA Astrophysics Data System (ADS)

    Sun, Hong; Zhang, JianHong

    2013-08-01

    This paper presents a novel unified coding analytical method for Internet of Things, which abstracts out the `displacement goods' and `physical objects', and expounds the relationship thereof. It details the item coding principles, establishes a one-to-one relationship between three-dimensional spatial coordinates of points and global manufacturers, can infinitely expand, solves the problem of unified coding in production phase and circulation phase with a novel unified coding method, and further explains how to update the item information corresponding to the coding in stages of sale and use, so as to meet the requirement that the Internet of Things can carry out real-time monitoring and intelligentized management to each item.

  6. Complex Chebyshev-polynomial-based unified model (CCPBUM) neural networks

    NASA Astrophysics Data System (ADS)

    Jeng, Jin-Tsong; Lee, Tsu-Tian

    1998-03-01

    In this paper, we propose complex Chebyshev Polynomial Based unified model neural network for the approximation of complex- valued function. Based on this approximate transformable technique, we have derived the relationship between the single-layered neural network and multi-layered perceptron neural network. It is shown that the complex Chebyshev Polynomial Based unified model neural network can be represented as a functional link network that are based on Chebyshev polynomial. We also derived a new learning algorithm for the proposed network. It turns out that the complex Chebyshev Polynomial Based unified model neural network not only has the same capability of universal approximator, but also has faster learning speed than conventional complex feedforward/recurrent neural network.

  7. Unified constitutive models for high-temperature structural applications

    NASA Technical Reports Server (NTRS)

    Lindholm, U. S.; Chan, K. S.; Bodner, S. R.; Weber, R. M.; Walker, K. P.

    1988-01-01

    Unified constitutive models are characterized by the use of a single inelastic strain rate term for treating all aspects of inelastic deformation, including plasticity, creep, and stress relaxation under monotonic or cyclic loading. The structure of this class of constitutive theory pertinent for high temperature structural applications is first outlined and discussed. The effectiveness of the unified approach for representing high temperature deformation of Ni-base alloys is then evaluated by extensive comparison of experimental data and predictions of the Bodner-Partom and the Walker models. The use of the unified approach for hot section structural component analyses is demonstrated by applying the Walker model in finite element analyses of a benchmark notch problem and a turbine blade problem.

  8. An Adaptive Unified Differential Evolution Algorithm for Global Optimization

    SciTech Connect

    Qiang, Ji; Mitchell, Chad

    2014-11-03

    In this paper, we propose a new adaptive unified differential evolution algorithm for single-objective global optimization. Instead of the multiple mutation strate- gies proposed in conventional differential evolution algorithms, this algorithm employs a single equation unifying multiple strategies into one expression. It has the virtue of mathematical simplicity and also provides users the flexibility for broader exploration of the space of mutation operators. By making all control parameters in the proposed algorithm self-adaptively evolve during the process of optimization, it frees the application users from the burden of choosing appro- priate control parameters and also improves the performance of the algorithm. In numerical tests using thirteen basic unimodal and multimodal functions, the proposed adaptive unified algorithm shows promising performance in compari- son to several conventional differential evolution algorithms.

  9. 49 CFR 800.25 - Delegation to the Directors of Office of Aviation Safety, Office of Railroad Safety, Office of...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 7 2013-10-01 2013-10-01 false Delegation to the Directors of Office of Aviation... Office of Aviation Safety, Office of Railroad Safety, Office of Highway Safety, Office of Marine Safety... Offices of Aviation, Railroad, Highway, Marine, and Pipeline and Hazardous Materials Safety, the...

  10. 49 CFR 800.25 - Delegation to the Directors of Office of Aviation Safety, Office of Railroad Safety, Office of...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 7 2012-10-01 2012-10-01 false Delegation to the Directors of Office of Aviation... Office of Aviation Safety, Office of Railroad Safety, Office of Highway Safety, Office of Marine Safety... Offices of Aviation, Railroad, Highway, Marine, and Pipeline and Hazardous Materials Safety, the...

  11. 49 CFR 800.25 - Delegation to the Directors of Office of Aviation Safety, Office of Railroad Safety, Office of...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 7 2014-10-01 2014-10-01 false Delegation to the Directors of Office of Aviation... Office of Aviation Safety, Office of Railroad Safety, Office of Highway Safety, Office of Marine Safety... Offices of Aviation, Railroad, Highway, Marine, and Pipeline and Hazardous Materials Safety, the...

  12. 49 CFR 800.25 - Delegation to the Directors of Office of Aviation Safety, Office of Railroad Safety, Office of...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 7 2011-10-01 2011-10-01 false Delegation to the Directors of Office of Aviation... Office of Aviation Safety, Office of Railroad Safety, Office of Highway Safety, Office of Marine Safety... Offices of Aviation, Railroad, Highway, Marine, and Pipeline and Hazardous Materials Safety, the...

  13. 75 FR 10293 - Office of Biotechnology Activities; Office of Science Policy; Office of the Director; Notice of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-05

    ... Biotechnology Activities; Office of Science Policy; Office of the Director; Notice of a Meeting of the NIH Blue..., Office of Biotechnology Activities, Office of Science Policy, Office of the Director, National Institutes... lewallenl@od.nih.gov . Dated: March 1, 2010. Amy P. Patterson, Director, Office of Biotechnology Activities...

  14. Unified method to integrate and blend several, potentially related, sources of information for genetic evaluation.

    PubMed

    Vandenplas, Jérémie; Colinet, Frederic G; Gengler, Nicolas

    2014-09-30

    A condition to predict unbiased estimated breeding values by best linear unbiased prediction is to use simultaneously all available data. However, this condition is not often fully met. For example, in dairy cattle, internal (i.e. local) populations lead to evaluations based only on internal records while widely used foreign sires have been selected using internally unavailable external records. In such cases, internal genetic evaluations may be less accurate and biased. Because external records are unavailable, methods were developed to combine external information that summarizes these records, i.e. external estimated breeding values and associated reliabilities, with internal records to improve accuracy of internal genetic evaluations. Two issues of these methods concern double-counting of contributions due to relationships and due to records. These issues could be worse if external information came from several evaluations, at least partially based on the same records, and combined into a single internal evaluation. Based on a Bayesian approach, the aim of this research was to develop a unified method to integrate and blend simultaneously several sources of information into an internal genetic evaluation by avoiding double-counting of contributions due to relationships and due to records. This research resulted in equations that integrate and blend simultaneously several sources of information and avoid double-counting of contributions due to relationships and due to records. The performance of the developed equations was evaluated using simulated and real datasets. The results showed that the developed equations integrated and blended several sources of information well into a genetic evaluation. The developed equations also avoided double-counting of contributions due to relationships and due to records. Furthermore, because all available external sources of information were correctly propagated, relatives of external animals benefited from the integrated

  15. The Marshall Engineering Thermosphere (MET) Model. Volume 1; Technical Description

    NASA Technical Reports Server (NTRS)

    Smith, R. E.

    1998-01-01

    Volume 1 presents a technical description of the Marshall Engineering Thermosphere (MET) model atmosphere and a summary of its historical development. Various programs developed to augment the original capability of the model are discussed in detail. The report also describes each of the individual subroutines developed to enhance the model. Computer codes for these subroutines are contained in four appendices.

  16. Seven Oaks Met School Builds Curriculum around Each Student

    ERIC Educational Resources Information Center

    Pearson, George

    2009-01-01

    This article features Seven Oaks School Division Met School in Winnipeg, a high school that limits class size to 15, tailors its curriculum to the needs and interests of its individual students, places students in community-based internships two days a week, and keeps the teacher--called an advisor--with the same group of students from Grade 9…

  17. San Diego Met High School: Personalization as a Foundation

    ERIC Educational Resources Information Center

    Principal Leadership, 2010

    2010-01-01

    The mission of San Diego Met High School is to prepare students for college and the workforce through active learning, academic rigor, and community involvement in a small school setting. Because personalization is a key component of the school culture, advisories of 20-25 students work with the same teachers for all four years. Advisers, parents,…

  18. NARSTO EPA SS ST LOUIS AIR CHEM PM MET DATA

    Atmospheric Science Data Center

    2014-05-07

    NARSTO EPA SS ST LOUIS AIR CHEM PM MET DATA Project Title:  NARSTO ... Amount Surface Pressure Solar Radiation Surface Air Temperature Particulates Trace Metals Order Data:  ... Data Guide Documents:  St Louis Air Chem Guide St Louis Final Report  (PDF) St Louis QA ...

  19. Altered White Matter Architecture in BDNF Met Carriers

    PubMed Central

    Ziegler, Erik; Foret, Ariane; Mascetti, Laura; Muto, Vincenzo; Le Bourdiec-Shaffii, Anahita; Stender, Johan; Balteau, Evelyne; Dideberg, Vinciane; Bours, Vincent; Maquet, Pierre; Phillips, Christophe

    2013-01-01

    Brain-derived neurotrophic factor (BDNF) modulates the pruning of synaptically silent axonal arbors. The Met allele of the BDNF gene is associated with a reduction in the neurotrophin's activity-dependent release. We used diffusion-weighted imaging to construct structural brain networks for 36 healthy subjects with known BDNF genotypes. Through permutation testing we discovered clear differences in connection strength between subjects carrying the Met allele and those homozygotic for the Val allele. We trained a Gaussian process classifier capable of identifying the subjects' allelic group with 86% accuracy and high predictive value. In Met carriers structural connectivity was greatly increased throughout the forebrain, particularly in connections corresponding to the anterior and superior corona radiata as well as corticothalamic and corticospinal projections from the sensorimotor, premotor, and prefrontal portions of the internal capsule. Interhemispheric connectivity was also increased via the corpus callosum and anterior commissure, and extremely high connectivity values were found between inferior medial frontal polar regions via the anterior forceps. We propose that the decreased availability of BDNF leads to deficits in axonal maintenance in carriers of the Met allele, and that this produces mesoscale changes in white matter architecture. PMID:23935975

  20. Early Field Experience: How Well Are Students' Expectations Met?

    ERIC Educational Resources Information Center

    Rekkas, Alexandria J.

    This study examined preservice teachers' expectations of their field experiences and how those expectations were met. The study population included primarily college sophomores who were either elementary or secondary education majors at a medium-sized university. An expectation checklist was given to 110 students prior to the field experience at…