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Sample records for metabolismo dei carboidrati

  1. Elaborazione dei dati sperimentali

    NASA Astrophysics Data System (ADS)

    Dapor, M.; Ropele, M.

    L'analisi statistica dei dati sperimentali, la loro elaborazione ed una corretta stima degli errori sono conoscenze necessarie agli studenti di fisica, biologia, chimica, ingegneria e dei corsi di specializzazione tecnico-scientifici in cui a di laboratorio. Chi si occupa di problemi tecnici e di misure, per studio o per lavoro, deve possedere gli strumenti matematici di calcolo e di analisi necessari ad una corretta interpretazione dei dati sperimentali. Il testo fornisce in modo sintetico, chiaro ed esaustivo, tutte le nozioni e le conoscenze utili allo scopo.

  2. Scienza dei servizi

    NASA Astrophysics Data System (ADS)

    Cavenago, Dario; Mezzanzanica, Mario

    I servizi sono oramai centrali nella vita sociale di ogni Paese. L'aspettativa di ogni attore sociale, sia esso cittadino/utente e/o istituzione, è quella di ricevere da uno scambio che ha alla base un servizio un contributo che si caratterizza per una qualità intrinseca. Il mantenimento di tale promessa richiede all'azienda erogatrice un forte coinvolgimento, nel disegno del servizio, degli utenti ed una capacità di gestione della conoscenza; ciò è particolarmente significativo per quei servizi che si caratterizzano per una forte personalizzazione o complessità progettuale. Disegnare un servizio, metterlo in produzione e gestirne l'erogazione ha una complessità variabile in base al grado di coinvolgimento dei destinati ed alle dimensioni critiche che esprimono le condizioni di fattibilità di un servizio di qualità appropriato alle attese degli utilizzatori. Ugualmente la globalizzazione dell'economia e la scarsità delle risorse ha portato l'attenzione, ai fini della sostenibilità delle condizioni sopra richiamate, di una ricerca di modelli e strumenti che permettano una valutazione e una standardizzazione dei processi di produzione ed erogazione secondo condizioni di economicità. Tali primi e sintetici elementi hanno condotto diversi attori istituzionali, grandi imprese ed università attraverso i loro centri di ricerca, ad una azione di riflessione sul grado di "ingegnerizzazione" dei processi sottesi alla erogazione dei servizi ed in particolare ai servizi che attuano le politiche dei grandi settori di base dell'economia di una Nazione: educazione, sanità, sociale, sviluppo infrastrutture ecc.

  3. The "Casa dei Bambini": A Century Concept.

    ERIC Educational Resources Information Center

    Hall, Elizabeth

    2000-01-01

    Reviews the early history of Montessori education from the Italian State Orthophrenic School to the opening of the original Casa dei Bambini in San Lorenzo, Italy on January 6, 1907. Includes a synopsis of Maria Montessori's progressive revelations of the child's developing self over the past century. (JPB)

  4. 47 CFR 1.1315 - The Draft Environmental Impact Statement (DEIS); Comments.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... the human environment. (b) When a DEIS and supplements, if any, are prepared, the Commission shall... 47 Telecommunication 1 2012-10-01 2012-10-01 false The Draft Environmental Impact Statement (DEIS... § 1.1315 The Draft Environmental Impact Statement (DEIS); Comments. (a) The DEIS shall include: (1)...

  5. 47 CFR 1.1315 - The Draft Environmental Impact Statement (DEIS); Comments.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false The Draft Environmental Impact Statement (DEIS... Environmental Impact Statement (DEIS); Comments. (a) The DEIS shall include: (1) A concise description of the... way to comment on the environmental impact of the facilities, a statement of his or her...

  6. 47 CFR 1.1315 - The Draft Environmental Impact Statement (DEIS); Comments.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 1 2013-10-01 2013-10-01 false The Draft Environmental Impact Statement (DEIS... § 1.1315 The Draft Environmental Impact Statement (DEIS); Comments. (a) The DEIS shall include: (1) A... qualified in any way to comment on the environmental impact of the facilities, a statement of his or...

  7. 47 CFR 1.1315 - The Draft Environmental Impact Statement (DEIS); Comments.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 1 2014-10-01 2014-10-01 false The Draft Environmental Impact Statement (DEIS... § 1.1315 The Draft Environmental Impact Statement (DEIS); Comments. (a) The DEIS shall include: (1) A... qualified in any way to comment on the environmental impact of the facilities, a statement of his or...

  8. Opus Dei Tutors Kids in Aquinas and Algebra.

    ERIC Educational Resources Information Center

    Kennedy, John W.

    1996-01-01

    Describes the mentorship programs of the Midtown Education Foundation (MEF), Chicago (Illinois), an initiative that began as an outreach of the Catholic Opus Dei movement. The MEF emphasis on biblically based character development, taught by role models, and embedded in an academic curriculum, is very popular. Early evaluation indicates that best…

  9. The Athletae Dei: Missing the Meaning of Sport.

    ERIC Educational Resources Information Center

    Hoffman, Shirl J.

    By making virtue of ascesis or self-discipline in their sport, the athlete evangelists (the "athletae-Dei"), unwittingly rob sport of its fundamental theological significance. These proponents of an evangelical brand of protestant theology have shifted drastically from an anti-sport stance of a century ago to a position that not only…

  10. Radioactivity level and toxic elemental concentration in groundwater at Dei-Dei and Kubwa areas of Abuja, north-central Nigeria

    NASA Astrophysics Data System (ADS)

    Maxwell, O.; Wagiran, H.; Lee, S. K.; Embong, Z.; Ugwuoke, P. E.

    2015-02-01

    The activity concentrations of uranium and toxic elements in Dei-Dei borehole, Kubwa borehole, Water Board and hand-dug well water samples in Abuja area were measured using inductively coupled plasma mass spectrometry (ICP-MS) system. The results obtained were used to calculate human radiological risk over lifetime consumption by the inhabitants in the area. The activity concentrations of 238U in all the water supplies for drinking ranges from 0.849 mBq L-1 to 2.699 mBq L-1 with the highest value of 2.699 mBq L-1 noted at Dei-Dei borehole whereas the lowest value of 0.849 mBq L-1 was noted in Kubwa borehole. The highest annual effective dose from natural 238U in all the water samples was found in Dei-Dei borehole with a value of 8.9×10-5 mSv y-1 whereas the lowest value was noted in Kubwa borehole with a value of 2.8×10-5 mSv y-1. The radiological risks for cancer mortality were found distinctly low, with the highest value of 1.01×10-7 reported at Dei-Dei borehole compared to Kubwa borehole with a value of 3.01×10-8. The cancer morbidity risk was noted higher in Dei-Dei borehole with a value of 1.55×10-7 whereas lower value of 4.88×10-9 was reported in Kubwa borehole. The chemical toxicity risk of 238U in drinking water over a lifetime consumption has a value of 0.006 μg kg-1 day-1 in Dei-Dei borehole whereas lower value of 0.002 μg kg-1 day-1 was found in Kubwa borehole. Measured lead (Pb) and chromium (Cr) concentrations reported higher in Water Board compared to Dei-Dei and Kubwa borehole samples. Significantly, this study inferred that the 238U concentrations originate from granitic strata of the tectonic events in the area; thus, there was a trend of diffusion towards north to south and re-deposition towards Dei-Dei area.

  11. Purification, characterization, and specificity of dextranase inhibitor (Dei) expressed from Streptococcus sobrinus UAB108 gene cloned in Escherichia coli.

    PubMed Central

    Sun, J W; Wanda, S Y; Curtiss, R

    1995-01-01

    The dextranase inhibitor gene (dei) from Streptococcus sobrinus UAB108 was previously cloned, expressed, and sequenced. Its gene product (Dei) has now been purified as a single band with apparent molecular mass of 43 kDa, as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The specific activity of Dei increased 121-fold upon purification. Most Dei activity (91.2%) was located in the periplasmic fraction from recombinant Escherichia coli cells. Dei competitively inhibits dextranase (Dex). This competitive inhibition mechanism has been further shown by detection and recovery of the intermediate enzyme-inhibitor (Dex-Dei) complex by gel filtration technology using fast protein liquid chromatography. Calibration of their molecular masses indicated that native Dei exists as a tetramer, Dex exists as dimer, and the Dex-Dei complex consists of two Dex molecules with two Dei molecules. Deletion analysis indicates that the intact Dei molecule is essential for Dei activity but not for glucan binding and immune cross-reaction. Dei is a special kind of glucan-binding protein with ability to inhibit Dex with high specificity. It can inhibit endogenous Dex, which can make more branches in glucan with the cooperation of the glucosyltransferase GTF-I. This inhibition cause the accumulation of water-soluble glucan. The latter reaction product can inhibit plaque formation and adherence of the mutans group of streptococcal cells. Dei derived from S. sobrinus UAB108 can inhibit only Dex from S. sobrinus (serotypes d and g), S. downei (previously S. sobrinus, serotype h), and S. macacae (serotype h). This finding suggests that Dei is another important protein existing in some serotypes of the mutans group of streptococci which participates in sucrose metabolism through its interaction with Dex. PMID:7896691

  12. 47 CFR 1.1315 - The Draft Environmental Impact Statement (DEIS); Comments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... proposal, the nature of the area affected, its uses, and any specific feature of the area that has special... preparation of a DEIS and the request for comments shall not open the application to attack on other grounds....

  13. 75 FR 17133 - Draft Environmental Impact Statement (DEIS) for Training Range and Garrison Support Facilities...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-05

    ... of Availability (NOA). SUMMARY: The Department of the Army has prepared a DEIS to analyze the... publication of an NOA in the Federal Register by the U.S. Environmental Protection Agency. ADDRESSES:...

  14. 76 FR 51395 - Draft Environmental Impact Statement for the General Management Plan (DEIS/GMP), Canaveral...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-18

    ... Seashore (Seashore). SUMMARY: Pursuant to 42 U.S.C. 4332(2)(C) of the National Environmental Policy Act of 1969 the NPS announces the availability of a DEIS/GMP for Canaveral National Seashore, Florida. The...-Action Alternative that continues current management policies and the NPS's preferred alternative....

  15. 77 FR 64836 - Notice of Availability of Draft Environmental Impact Statement (DEIS), Draft Section 4(f...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-23

    ... following the links to the PUBLIC COMMENT FORM. Additionally, comments can be emailed to Leslie.Grey@faa.gov... specific references to the text of the DEIS and related documents. Matters that could have been raised with...: Leslie Grey, Environmental Specialist, Federal Aviation Administration, Alaskan Region, Airports...

  16. 76 FR 22684 - Draft Environmental Impact Statement (DEIS) for the Real Property Master Plan at the Presidio of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-22

    ... (NOA). SUMMARY: The Department of the Army announces the availability of the DEIS for the Real Property... coast. DATES: The public comment period will end 45 days after publication of the NOA in the...

  17. Probing Alzheimers Disease Pathology and Early Detection at the NSLS with Infrared, XRF, and DEI

    SciTech Connect

    Zhong,Z.; Bennett, D.; Chapman, D.; Chen, J.; Connor, D.; Dilmanian, A.; Faulconer, L.; Kao, T.; Leskovjan, A.; et al

    2008-01-01

    We explored diffraction enhanced imaging (DEI) in both planar and computed tomography (CT) modes for early detection of beta amyloid deposition, a hallmark feature in Alzheimer's disease (AD). Since amyloid plaques precede clinical symptoms by years, their early detection is of great interest. These findings were correlated with results from synchrotron infrared microspectroscopic imaging and X-ray fluorescence microscopy, to determine the secondary structure of the amyloid beta protein and metal concentration in the amyloid plaques, respectively.

  18. Comparison of activity concentration of 238U, 232Th and 40K in different Layers of subsurface Structures in Dei-Dei and Kubwa, Abuja, northcentral Nigeria

    NASA Astrophysics Data System (ADS)

    Maxwell, Omeje; Wagiran, Husin; Ibrahim, Noorddin; Lee, Siak Kuan; Sabri, Soheil

    2013-10-01

    The study of activity concentration of 232Th, 238U and 40K of rock samples from site one (S1L1-S1L11, 70 m) and site two (S2L1-S2L9, 60 m) boreholes in Dei-Dei and Kubwa was presented and the first time in the region to be compared. Activity concentrations were analysed using a high resolution co-axial HPGe gamma ray spectrometer system. The activity concentration ranges in site one borehole were from 45±1 to 98±6 Bq kg-1 for 232Th, from 18±2 to 37±4 Bq kg-1 for 238U and from 254 ±32 Bq kg-1 to 1195 ±151 Bq kg-1 for 40K. The activity concentration ranges in site two borehole were from 32±3 to 84±7 Bq kg-1 for 232Th, from 15±2 to 52±5 Bq kg-1 for 238U and from 119±15 to 705±94 for 40K Bq kg-1. Significantly higher concentration of 232Th and 238U occurs in samples collected from S1L7, S1L11 and S2L1 layers. These zones experienced granitic intrusions produced by denudation and tectonism. 40K in rock samples of S1L4 and S2L4 activity concentrations is close; it could be that biotite granitic intrusion that is inferred as the formation in that layer reflects the same activity of potassium in rock's radioactivity measurement. The area requires further investigation of soil geochemistry and activity concentration of radionuclides in groundwater.

  19. Imaging lobular breast carcinoma: comparison of synchrotron radiation DEI-CT technique with clinical CT, mammography and histology

    NASA Astrophysics Data System (ADS)

    Fiedler, S.; Bravin, A.; Keyriläinen, J.; Fernández, M.; Suortti, P.; Thomlinson, W.; Tenhunen, M.; Virkkunen, P.; Karjalainen-Lindsberg, M.-L.

    2004-01-01

    Different modalities for imaging cancer-bearing breast tissue samples are described and compared. The images include clinical mammograms and computed tomography (CT) images, CT images with partly coherent synchrotron radiation (SR), and CT and radiography images taken with SR using the diffraction enhanced imaging (DEI) method. The images are evaluated by a radiologist and compared with histopathological examination of the samples. Two cases of lobular carcinoma are studied in detail. The indications of cancer are very weak or invisible in the conventional images, but the morphological changes due to invasion of cancer become pronounced in the images taken by the DEI method. The strands penetrating adipose tissue are seen clearly in the DEI-CT images, and the histopathology confirms that some strands contain the so-called 'Indian file' formations of cancer cells. The radiation dose is carefully measured for each of the imaging modalities. The mean glandular dose (MGD) for 50% glandular breast tissue is about 1 mGy in conventional mammography and less than 0.25 mGy in projection DEI, while in the clinical CT imaging the MGD is very high, about 45 mGy. The entrance dose of 95 mGy in DEI-CT imaging gives rise to an MGD of 40 mGy, but the dose may be reduced by an order of magnitude, because the contrast is very large in most images.

  20. OCT structural examination of Madonna dei Fusi by Leonardo da Vinci

    NASA Astrophysics Data System (ADS)

    Targowski, Piotr; Iwanicka, Magdalena; Sylwestrzak, Marcin; Kaszewska, Ewa A.; Frosinini, Cecilia

    2013-05-01

    Madonna dei Fusi (`Madonna of the Yarnwider') is a spectacular example of Italian Renaissance painting, attributed to Leonardo da Vinci. The aim of this study is to give an account of past restoration procedures. The evidence of a former retouching campaign will be presented with cross-sectional images obtained non-invasively with Optical Coherence Tomography (OCT). Specifically, the locations of overpaintings/retouchings with respect to the original paint layer and secondary varnishes will be given. Additionally, the evidence of a former transfer of the pictorial layer to the new canvas support by detecting the presence of its structure incised into paint layer will be shown.

  1. La meridiana di Egnazio Danti nella Torre dei Venti in Vaticano: un'icona della riforma Gregoriana del calendario

    NASA Astrophysics Data System (ADS)

    Sigismondi, Costantino

    2014-05-01

    La Torre dei Venti domina l’angolo Sud Ovest del cortile della Pigna (nell'area dei Musei Vaticani), ed è inclusa negli ambienti dell'Archivio Segreto Vaticano. Non è aperta al pubblico, ma è universalmente nota per la fama che da oltre quattrocento anni la circonda, legata alle vicende della riforma Gregoriana del calendario. La meridiana tracciata da padre Egnazio Danti (1536-1586) nella torre dei Venti, fu visitata anche da Gregorio XIII, probabilmente il 21 marzo 1581 come suppone il padre Stein, per convincersi dell'anticipo ormai arrivato a dieci giorni dell'equinozio di primavera sulla data che il concilio di Nicea aveva fissato al 21 marzo per il computo pasquale. La ricognizione astrometrica del febbraio-marzo 2009 fatta dall'autore viene qui presentata.

  2. 75 FR 68312 - Notice of Availability of a Draft Environmental Impact Statement (DEIS) for New Medium- and Heavy...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-05

    ... proposing fuel consumption standards under the Energy Independence and Security Act of 2007 (EISA),\\2\\ and... Draft Environmental Impact Statement (DEIS) for New Medium- and Heavy-Duty Fuel Efficiency Improvement... fuel consumption standards for commercial medium- and heavy-duty on-highway vehicles and work...

  3. 76 FR 50187 - Intent To Prepare a Draft Environmental Impact Statement (DEIS) for a Study on the Feasibility of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-12

    ...) for a Study on the Feasibility of Deepening Charleston Harbor AGENCY: Department of the Army, U.S... Charleston Harbor Deepening Study (Post-45 study). The purpose of this DEIS and feasibility study is to... conducted in the proposed feasibility phase and would likely involve evaluation of all alternatives...

  4. Gas hazard assessment in a densely inhabited area of Colli Albani Volcano (Cava dei Selci, Roma)

    NASA Astrophysics Data System (ADS)

    Carapezza, M. L.; Badalamenti, B.; Cavarra, L.; Scalzo, A.

    2003-04-01

    The northwestern flank of the Colli Albani, a Quaternary volcanic complex near Rome, is characterised by high pCO 2 values and Rn activities in the groundwater and by the presence of zones with strong emission of gas from the soil. The most significant of these zones is Cava dei Selci where many houses are located very near to the gas emission site. The emitted gas consists mainly of CO 2 (up to 98 vol%) with an appreciable content of H 2S (0.8-2%). The He and C isotopic composition indicates, as for all fluids associated with the Quaternary Roman and Tuscany volcanic provinces, the presence of an upper mantle component contaminated by crustal fluids associated with subducted sediments and carbonates. An advective CO 2 flux of 37 tons/day has been estimated from the gas bubbles rising to the surface in a small drainage ditch and through a stagnant water pool, present in the rainy season in a topographically low central part of the area. A CO 2 soil flux survey with an accumulation chamber, carried out in February-March 2000 over a 12 000 m 2 surface with 242 measurement points, gave a total (mostly conductive) flux of 61 tons/day. CO 2 soil flux values vary by four orders of magnitude over a 160-m distance and by one order of magnitude over several metres. A fixed network of 114 points over 6350 m 2 has been installed in order to investigate temporal flux variations. Six surveys carried out from May 2000 to June 2001 have shown large variations of the total CO 2 soil flux (8-25 tons/day). The strong emission of CO 2 and H 2S, which are gases denser than air, produces dangerous accumulations in low areas which have caused a series of lethal accidents to animals and one to a man. The gas hazard near the houses has been assessed by continuously monitoring the CO 2 and H 2S concentration in the air at 75 cm from the ground by means of two automatic stations. Certain environmental parameters (wind direction and speed; atm P, T, humidity and rainfall) were also

  5. Composition and stratigraphy of the paint layers: investigation on the Madonna dei Fusi by ion beam analysis techniques

    NASA Astrophysics Data System (ADS)

    Grassi, N.

    2005-06-01

    In the framework of the extensive study on the wood painting "Madonna dei fusi" attributed to Leonardo da Vinci, Ion Beam Analysis (IBA) techniques were used at the Florence accelerator laboratory to get information about the elemental composition of the paint layers. After a brief description of the basic principle and the general features of IBA techniques, we will illustrate in detail how the analysis allowed us to characterise the pigments of original and restored areas and the substrate composition, and to obtain information about the stratigraphy of the painting, also providing an estimate of the paint layer thickness.

  6. Near-surface geophysical investigations inside the cloister of the historical palace 'Palazzo dei Celestini' in Lecce, Italy

    NASA Astrophysics Data System (ADS)

    Nuzzo, Luigia; Quarta, Tatiana

    2010-06-01

    Non-invasive geophysical investigations are usually the only way to gain information on subsurface properties that can affect the stability of historical structures and accelerate degradation processes. A combined multi-frequency ground-penetrating radar (GPR) geoelectrical and induced polarization (IP) survey was performed in the cloister of 'Palazzo dei Celestini', Lecce, southern Italy, in order to investigate possible subsurface causes of deterioration. The historical palace was originally a convent connected to the Basilica of 'Santa Croce' and is now the head office of the Province of Lecce Administration and the Prefecture. Built in Pietra Leccese, a fine-grained calcarenite, Santa Croce and Palazzo dei Celestini is the most famous baroque architectural complex of the historical centre of Lecce. The high capillarity of the building material causes deterioration problems especially at some altars of the church and in the lower portion of the walls and pillars of the monumental building. The integrated geophysical survey yielded a detailed description of the shallow stratigraphical and hydro-geological setting of the area and an accurate location of ancient and modern drainage systems. The geophysical information was essential for identifying natural or anthropogenic causes of the local increase in subsoil moisture that could accelerate the degradation process and for developing effective remediation activities.

  7. THE DRAINAGE EFFICIENCY INDEX (DEI) AS AN MORPHOLOGIAL INDICATOR OF LANDSLIDE SPATIAL OCCURRENCE IN MOUNTAINOUS CATCHMENTS. A case of study applied in the mountainous region of Brazilian Southeastern.

    NASA Astrophysics Data System (ADS)

    Henrique Muniz Lima, Pedro; Luiza Coelho Netto, Ana; do Couto Fernandes, Manoel

    2016-04-01

    Morphometric parameters, acquired notoriety mainly after the Drainage Density proposition (Horton 1932, 1945) and after they were applied by geomorphologists on the perspective to understand landscape functionalities, quantifying their characteristics through parameters and indexes. After the drainage density, many other parameters which describe the basin characteristics, behavior and dynamics have been proposed. Among them, for example, the DEI was proposed by Coelho Netto and contributors during the 80's, while they were seek to understand the hydrological and erosive dynamics on Bananal river basin (Brazilian Southeastern). Through this investigations the DEI was created, revealing the importance of parameters as hollow and drainage density, conjugated to the topographic gradient (Meis et al. 1982) who prosecute controls on the water flow efficiency along the hollows in order to activate the regressive erosion of the main channel. Later on this index was applied on the basin scale in several works developed in mountainous regions, showing a remarkable correlation with the occurrence of landslides such as showed by Coelho Netto et al. (2007); that posteriorly use this index as one of the components of the landslide susceptibility map for the Tijuca Massif, located in Rio de Janeiro Municipality. This work aims to establish patterns of the DEI index values (applied to mountainous low order basins) and the relationship on the occurrence of Debriflows or shallow translational slides. For this, the DEI index was applied on 4 different study areas located on the Southeastern mountainous region of Brazil to address deeply the connection between the index and the occurrence of landslides of different types applied for first and second order basins. The major study area is the Córrego Dantas Basin, situated in Nova Friburgo municipality (RJ), which is a 53 km² basin was affected by 327 landslides caused by a heavy rainfall on January 2011; Coelho Netto et al. (in

  8. From Point Cloud to Digital Fabrication: a Tangible Reconstruction of Ca' Venier Dei Leoni, the Guggenheim Museum in Venice

    NASA Astrophysics Data System (ADS)

    Balletti, C.; D'Agnano, F.; Guerra, F.; Vernier, P.

    2016-06-01

    The paper describes how new digital methodologies can be used within the field of Cultural Heritage, not only with the aim of documenting the actual state of an architecture but to review the past transformations it has undergone, conserving and representing these histories as well. The premise to conservation and enhancement of our Heritage is a deep study in terms of position, shape, colour, and also of the historical and artistic features. Survey methods have acquired data acquisition techniques in line with technological progress: today's electronic and IT technologies, that are the tools of modern Geomatics, allow the effective survey and representation of 3D objects, from architectural structures to sculptures or archaeological finds. Over the last few years, the methodologies of acquisition and integrated representation for 3D patrimony documentation have developed and consolidated considerably: the possibilities of the digital realm can augment the understanding and the valorisation of a monument. The specific case offered in the present paper, Ca' Venier dei Leoni, the palace where is the Guggenheim Museum in Venice, is a significant example. It suggests not only the theme of the "no longer existing", or better never built, but also the opportunity to formulate hypotheses regarding its implementation and the impact that the palace would have had in the Venetian contest.

  9. 2D and 3D optical diagnostic techniques applied to Madonna dei Fusi by Leonardo da Vinci

    NASA Astrophysics Data System (ADS)

    Fontana, R.; Gambino, M. C.; Greco, M.; Marras, L.; Materazzi, M.; Pampaloni, E.; Pelagotti, A.; Pezzati, L.; Poggi, P.; Sanapo, C.

    2005-06-01

    3D measurement and modelling have been traditionally applied to statues, buildings, archeological sites or similar large structures, but rarely to paintings. Recently, however, 3D measurements have been performed successfully also on easel paintings, allowing to detect and document the painting's surface. We used 3D models to integrate the results of various 2D imaging techniques on a common reference frame. These applications show how the 3D shape information, complemented with 2D colour maps as well as with other types of sensory data, provide the most interesting information. The 3D data acquisition was carried out by means of two devices: a high-resolution laser micro-profilometer, composed of a commercial distance meter mounted on a scanning device, and a laser-line scanner. The 2D data acquisitions were carried out using a scanning device for simultaneous RGB colour imaging and IR reflectography, and a UV fluorescence multispectral image acquisition system. We present here the results of the techniques described, applied to the analysis of an important painting of the Italian Reinassance: `Madonna dei Fusi', attributed to Leonardo da Vinci.

  10. Unravelling the effusive-explosive transitions and the construction of a volcanic cone from geological data: The example of Monte dei Porri, Salina Island (Italy)

    NASA Astrophysics Data System (ADS)

    Sulpizio, Roberto; Lucchi, Federico; Forni, Francesca; Massaro, Silvia; Tranne, Claudio

    2016-11-01

    The volcanic activity that built up the Monte dei Porri stratocone (Salina Island) was reconstructed using new stratigraphic data, which allowed seven eruption units to be distinguished. Alternating Strombolian/Vulcanian to sub-Plinian/Plinian explosive and effusive activity emplaced fall and pyroclastic density current deposits and lava flows that formed the volcanic cone. The minimum erupted bulk volumes were assessed at 100 × 106 m3 each for EU1, EU2, EU3 and EU6, while that of EU4 is ca. 200 × 106 m3. Rough estimation of EU7 volume yields values around 150 × 106 m3. The calculation of volume was not possible for the EU5 deposits. The magmas that fed the different eruption units of the Monte dei Porri succession range in composition from basalt to andesite, with the exception of dacites erupted in the initial phase of activity. SEM image analyses on coarse ash from the different pyroclastic units suggest that hydromagmatic fragmentation cannot be the cause of the large variations in explosivity observed throughout the stratigraphic succession. Based on the lithic component of pyroclastic deposits and xenolith contents of lava flows, the plumbing system that fed the different eruption units of Monte dei Porri was split into a deep magma storage level (15-20 km) and shallower magma batches (3-5 km). Our calculations indicate that the volumes of erupted material can account for magmatic triggering (injection of new magma) of eruptive units from the shallower feeding system, but they are not sufficient for suggesting magmatic initiation of the eruption units from the deeper feeding system. It is therefore assumed that the eruptions from the deep magma reservoir necessitate a favourable lithostatic stress, likely calling for a reduction of the local tectonic forces. A qualitative model explaining the eruptive style transitions among and within the different eruption units is presented, taking into account the relation between magmatic overpressure and lithostatic

  11. Cork Embedded Internal Features and Contrast Mechanisms with DEI using 18, 20, 30, 36, and 40 kev Synchrotron X-rays

    SciTech Connect

    Donepudi, R.; Cesareo, R; Brunetti, A; Zhong, Z; Yuasa, T; Takeda, T; Gigante, G

    2010-01-01

    Images of the cork used for wine and other bottles are visualized with the use of diffraction-enhanced imaging (DEI) technique. Present experimental studies allowed us to identify the cracks, holes, porosity, and importance of soft-matter (soft-material) and associated biology by visualization of the embedded internal complex features of the biological material such as cork and its microstructure. Highlighted the contrast mechanisms above and below the K-absorption edge of iodine and studied the attenuation through a combination of weakly and strongly attenuating materials.

  12. Mapping transitions between healthy and pathological lesions in human breast tissues by diffraction enhanced imaging computed tomography (DEI-CT) and small angle x-ray scattering (SAXS)

    NASA Astrophysics Data System (ADS)

    Conceição, A. L. C.; Antoniassi, M.; Geraldelli, W.; Poletti, M. E.

    2014-02-01

    In this work we have combined the DEI-CT and SAXS technique to study the transition between healthy and pathological breast tissues, which include benign and malignant lesions. The ability of DEI-CT to enhance the contrast between soft tissues was used to localize the tumor region in the sample. Then, the tumor region and its surroundings were scanned by SAXS in order to map the changes promoted by the neoplasias at nano-level.It was clearly observed that pathological tissues present distinguishable SAXS scattering profiles from those of normal tissue. These differences are mainly related to changes in arrangement and diameter of collagen fibrils, evaluated by the higher order of reflection peaks of these fibrils. Differences related to the peak intensities and the total scattered intensity were found by comparing the healthy and pathological regions. The 2nd order of collagen reflection arises only in the healthy region neighboring the benign lesion. A broader peak at q=0.16 nm-1 seems to characterize the malignant lesions. Finally, based on this information, the transition between healthy and pathological human breast tissues was mapped which allowed to get insights into the changes promoted by tumors during growth and progression.

  13. Bulk rock composition and geochemistry of olivine-hosted melt inclusions in the Grey Porri Tuff and selected lavas of the Monte dei Porri volcano, Salina, Aeolian Islands, southern Italy

    USGS Publications Warehouse

    Doherty, Angela L.; Bodnar, Robert J.; De Vivo, Benedetto; Bohrson, Wendy A.; Belkin, Harvey E.; Messina, Antonia; Tracy, Robert J.

    2012-01-01

    The Aeolian Islands are an arcuate chain of submarine seamounts and volcanic islands, lying just north of Sicily in southern Italy. The second largest of the islands, Salina, exhibits a wide range of compositional variation in its erupted products, from basaltic lavas to rhyolitic pumice. The Monte dei Porri eruptions occurred between 60 ka and 30 ka, following a period of approximately 60,000 years of repose. The bulk rock composition of the Monte dei Porri products range from basaltic-andesite scoria to andesitic pumice in the Grey Porri Tuff (GPT), with the Monte dei Porri lavas having basaltic-andesite compositions. The typical mineral assemblage of the GPT is calcic plagioclase, clinopyroxene (augite), olivine (Fo72−84) and orthopyroxene (enstatite) ± amphibole and Ti-Fe oxides. The lava units show a similar mineral assemblage, but contain lower Fo olivines (Fo57−78). The lava units also contain numerous glomerocrysts, including an unusual variety that contains quartz, K-feldspar and mica. Melt inclusions (MI) are ubiquitous in all mineral phases from all units of the Monte dei Porri eruptions; however, only data from olivine-hosted MI in the GPT are reported here. Compositions of MI in the GPT are typically basaltic (average SiO2 of 49.8 wt %) in the pumices and basaltic-andesite (average SiO2 of 55.6 wt %) in the scoriae and show a bimodal distribution in most compositional discrimination plots. The compositions of most of the MI in the scoriae overlap with bulk rock compositions of the lavas. Petrological and geochemical evidence suggest that mixing of one or more magmas and/or crustal assimilation played a role in the evolution of the Monte dei Porri magmatic system, especially the GPT. Analyses of the more evolved mineral phases are required to better constrain the evolution of the magma.

  14. Superimposed positive and negative inversion of the syn-rift fault network preserved in the Montagna dei Fiori Anticline, Central Apennines, Italy

    NASA Astrophysics Data System (ADS)

    Storti, Fabrizio; Balsamo, Fabrizio; Koopman, Anton; Mozafari, Mahtab; Solum, John; Swennen, Rudy; Taberner, Conxita

    2016-04-01

    Syn-rift tectono-sedimentary inheritance is common in thrust-related anticlines exposed in most foreland thrust-fold belts worldwide. Inherited extensional faults provide mechanical weakness zones that typically undergo positive inversion during contraction. This unavoidably has an impact on the evolution of contractional folds. Moreover, duplexing and imbrication of thrust sheets typically produce gravitational instability of inherited fault patterns and negative inversion can be triggered in the late stages of fault-fold interaction. Such polyphase evolutionary histories can deeply influence deformation and fluid flow patterns in fault-related folds and therefore can strongly influence the distribution of structurally controlled processes such as dolomitization. In this contribution we present the results obtained from a multidisciplinary study of the tectono-sedimentary pattern and paleofluid history in carbonates exposed in the Montagna dei Fiori Anticline, at the mountain front of the Central Apennines (central Italy), where the occurrence of both syn-rift fault zones and related sediments has been previously described. Detailed mapping of the central part of the anticline, bed-perpendicular logging of syn-rift and post-rift strata, structural, petrographical, geochemical, microthermometrical, and petrophysical analyses were used to reconstruct the evolution of this anticline, starting from the pre-orogenic architecture up to its subsequent orogenic reworking. These data reveal: (1) the pre-orogenic tectono-sedimentary architecture of a folded Jurassic fault network; (2) multiple superimposition of extensional and contractional episodes of deformation on the same fault zones; (3) the presence of at least one main dolomitization episode, the timing of which is still being deciphered; (4) demonstrate the causal link between faulting and dolomitization, which favoured formation of dolostones along fault zones, particularly in the intersection/abutting areas

  15. 79 AD Vesuvius PDC deposits' temperatures inferred from optical analysis on woods charred in-situ in the Villa dei Papiri at Herculaneum (Italy)

    NASA Astrophysics Data System (ADS)

    Caricchi, C.; Vona, A.; Corrado, S.; Giordano, G.; Romano, C.

    2014-12-01

    Determining the deposit temperature of pyroclastic density currents (PDCs) is a first order priority in the assessment of volcanic hazard. For past eruptions, in which no direct measurements are possible, PDC deposit temperatures have been calculated mainly using magnetic proxies. A more recent and innovative approach consists of the determination of the degree of charring of preserved wood fragments by optical analysis. In this study, we perform optical analyses on wooden beams belonging to the Villa dei Papiri at the archeological site of Herculaneum, which was destroyed by PDCs during the 79 AD eruption of Vesuvius. The new temperature data from this study range between 240 °C and 370 °C, and are in good agreement with literature data for this eruption. The large T variation measured can be interpreted as due to the interaction of the PDCs with the local environment, i.e. the impacted buildings of the villa and the sea shoreline. The study of in situ charred wood allows to constrain the charring kinetics and to evaluate the sensitivity of the reflectance proxy in recording PDC depositional features. We demonstrate that the charcoal reflectance is an excellent proxy for the determination of the PDC deposit temperatures even at a local scale, and it can be used in conjunction with, or in alternative to other more traditional methodologies, especially in case of pre-heating effects which may alter the T determinations by thermoremanent magnetization.

  16. Fiber optic reflectance spectroscopy and hyper-spectral image spectroscopy: two integrated techniques for the study of the Madonna dei Fusi

    NASA Astrophysics Data System (ADS)

    Casini, A.; Bacci, M.; Cucci, C.; Lotti, F.; Porcinai, S.; Picollo, M.; Radicati, B.; Poggesi, M.; Stefani, L.

    2005-06-01

    Reflectance spectroscopy supplies fundamental information for investigating art objects and diagnosing their state of conservation. Until recently, reflectance spectra could be measured only on samples taken from the art objects. Recent progresses in fiber optics reflectance spectroscopy (FORS) and image spectroscopy (IS) have made it possible, however, to perform non-invasive measurements. Moreover, the two techniques can supply data in large enough quantities as to make the use of sophisticated statistical methods significant for detecting variations due to ageing and degradation. FORS and IS are, in a sense, complementary techniques as the former provides information on single points, while the latter provides 2-D maps from which the reflectance spectrum of each pixel can be displayed. Both FORS and IS were applied in the case study on the Lansdowne version of the Madonna dei fusi (Madonna of the Yarnwinder). In particular, IS was realized by means of a hyper-spectral scanner recently assembled at the "Nello Carrara" Istituto di Fisica Applicata. The characteristics of the scanner are: 0.1 mm spatial sampling over a 1x1 m2 surface and ~1 nm spectral sampling in the wavelength range from 400 nm to 900 nm. The information provided by these two techniques was consistent with what supplied by the non-invasive techniques employed by the other teams participating in the case study, in particular as regards the pigments, the preparatory layer, the binding medium, and the previous restoration works.

  17. Draft Environmental Impact Statement (DEIS)

    DTIC Science & Technology

    2007-11-02

    Colaptes auratus American crow Corvus brachyrhynchos blue jay Cyanocitta cristata yellow warbler Dendroica petechia wood thrush Hylocichla...22192-5073 Attn: Sandra Oliver Central Rappahannock Regional Library 1201 Caroline Street Fredericksburg,VA 22401 Attn: Ann Haley

  18. Impact of nutrition since early life on cardiovascular prevention

    PubMed Central

    2012-01-01

    preventivo fondamentale sin dall’epoca prenatale e nelle diverse età della crescita. La condizione metabolica e neuro-endocrino cui è sottoposto il feto è rilevante per la “programmazione metabolica”. E’ dimostrata inoltre l’importanza delle modalità di allattamento e divezzamento con particolare interesse per l’assunzione di proteine nel controllo dei fattori di rischio cardiovascolari. La corretta distribuzione di macronutrienti (lipidi, proteine e carboidrati) dall’infanzia all’adolescenza favorisce una crescita corretta e risulta utile a prevenire l’insorgenza dei determinanti di rischio di malattia cardiovascolare in età adulta. Nella presente review verrà esaminato l’impatto della nutrizione dalle più precoci fasi delle vita sul rischio cardiovascolare. PMID:23259704

  19. Defense Energy Information System (DEIS): DEIS-80 Design System Specification. Revision A.

    DTIC Science & Technology

    1981-07-01

    P63387 REDCOM SAN DIEGO N68350 047740 REDCOM TREASURE IS N68308 040061 NAVELEXSYSENGCEN, VALLEJO N63274 047414 NSWSES PORT HUENEME, OXNARD, CA N63394...047740 NAVSPASUR SAN DIEGO, CA N66079 047740 NH LEMOORE, CA N66095 044900 NSA MARE ISLAND, CA, VALLEJO N66890 047414 MT VALLEJO , CA N67030 047414 NEMC...983270* WALLACE AS PHILIPPINES, SAN FERNANDO FG5250 983270* PHIL CLARK AB, ANGELES, PHIL FP5250 983270* NSD SUBIC PHILIPPINES N00651 984260* NCS

  20. Defense Energy Information System (DEIS): DEIS-80 Design System Specification. Revision B,

    DTIC Science & Technology

    1982-07-01

    P63387 REDCOM SAN DIEGO N68350 047740 REDCOM TREASURE IS N68308 040061 NAVELEXSYSENGCEN, VALLEJO N63274 047414 NSWSES PORT HUENEME, OXNARD, CA N63394...047740 NDC SAN DIEGO, CA N66022 047740 NAVSPASUR SAN DIEGO, CA N66079 047740 NH LEMOORE, CA N66095 044900 NSA MARE ISLAND, CA, VALLEJO N66890...047414 MT VALLEJO , CA N67030 047414 NRMC SAN DIEGO, CA N68056 047740 RNMC LONG BEACH, CA N68090 045085 NRMC OAKLAND, CA N68097, D68097 046335 NAF EL

  1. An Examination of the Oral Language Competence of Junior Infant Pupils Attending DEIS and Non-DEIS Schools

    ERIC Educational Resources Information Center

    Molloy, Grace; Murtagh, Lelia; McAvinue, Laura P.

    2016-01-01

    Educational disadvantage remains a serious issue in Irish society. Research has suggested that differing styles and levels of competence in oral language may have implications for educational attainment across socio-economic groups. The current study involved an examination of the oral language competence of Irish children in Junior Infants in…

  2. The Hungry Mind: From the Casa dei Bambini to Cosmic Education

    ERIC Educational Resources Information Center

    Grazzini, Baiba Krumins

    2016-01-01

    Baiba Krumins Grazzini has generously transformed her lecture, delivered at the AMI-USA Refresher Course in 2014, into a legacy article. This article establishes the role of storytelling in Cosmic Education while capturing both the whole and the detailed parts of Montessori Cosmic Education. Working from the early childhood transition into the…

  3. 2° simposio europeo dei planetari, Parigi 6 - 8 maggio 1988.

    NASA Astrophysics Data System (ADS)

    Gambato, G.; Talamoni, L.

    The second European symposium on planetariums has been held in Paris, between May 6th and 8th, 1988. The paper reports the different experiences presented at the meeting about the planetariums management.

  4. 76 FR 3925 - Notice of Intent To Prepare a Draft Environmental Impact Statement (DEIS) for Housing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-21

    ... Privately- Owned and Operated Institution in Either Hinton, OK; McRae, GA; Baldwin, MI; or Scott County, MS... either Hinton, Oklahoma; McRae, Georgia; Baldwin, Michigan; or Scott County, Mississippi. SUPPLEMENTARY..., Oklahoma; McRae, Georgia; Baldwin, Michigan; and a new facility proposed for development in Scott...

  5. Analysis of Maximum Reasonably Foreseeable Accidents for the Yucca Mountain Draft Environmental Impact Statement (DEIS)

    SciTech Connect

    S.B. Ross; R.E. Best; S.J. Maheras; T.I. McSweeney

    2001-08-17

    Accidents could occur during the transportation of spent nuclear fuel and high-level radioactive waste. This paper describes the risks and consequences to the public from accidents that are highly unlikely but that could have severe consequences. The impact of these accidents would include those to a collective population and to hypothetical maximally exposed individuals (MEIs). This document discusses accidents with conditions that have a chance of occurring more often than 1 in 10 million times in a year, called ''maximum reasonably foreseeable accidents''. Accidents and conditions less likely than this are not considered to be reasonably foreseeable.

  6. Appunti per la biografia linguistica dei miei figli (Notes for a Linguistic Biography of My Children).

    ERIC Educational Resources Information Center

    Francescato, Giuseppe

    1978-01-01

    This article discusses the linguistic background of two Italian children who lived with their parents for an extended period of time in Holland and for a brief time in Puerto Rico and spent vacations in Italy where their relatives spoke the dialects of Veneto and Friuli. (CFM)

  7. Dalla A alla Z: l'alfabeto dei bambini (From A to Z: The Children's Alphabet).

    ERIC Educational Resources Information Center

    Palandra, Maria; Cardone, Romolo

    This Italian alphabet book designed for kindergarten and first grade students presents each letter in upper and lower case form accompanied by an illustration and a single sentence caption. The sentence contains two or more words that begin with the letter in question. The book has a teacher's introduction and is illustrated by pen-and-ink…

  8. Environmental Impact Analysis Process. Deployment Area Selection and Land Withdrawal/Acquisition DEIS. Chapter V. Appendices.

    DTIC Science & Technology

    1980-12-01

    Projectile Points Arrowheads whose flaking is characteristic of Upper Paleolithic times. Fluvial Of or pertaining to a river; produced by the action of a...plant community. Fluted Projectile Points Arrowheads whose flaking is characteristic of Upper Paleolithic times. Fluvial Of or pertaining to a river

  9. Biagio Bartalini's "Catalogo dei corpi marini fossili che se trovano intorno a Siena" (1776).

    PubMed

    Manganelli, Giuseppe; Benocci, Andrea; Spadini, Valeriano

    2011-01-01

    In 1776, the Sienese botanist Biagio Bartalini (1750-1822) published a catalogue of wild plants growing around Siena, adding an appendix on fossils found in the same area, that is the first monograph on Sienese fossils and one of the first works of its kind in Italy. This paper provides tentative identifications of the species and an analysis of the value and meaning of Bartalini's work. The catalogue reports 72 species, each denoted by a list of names applied to analogous living taxa. Identification of single entities is extremely problematical because it can only be attempted through analysis of the literature, since the original material cannot be traced. The most interesting report is the first record of a Euro-Mediterranean Pliocene species of Sthenorytis (Gastropoda, Epitoniidae). Though important, the catalogue is incomplete, with oversights and mistakes, suggesting little familiarity with the subject. Shortcomings include some inconsistencies in the species sequence, the report of giant clams and the absence of molluscs ubiquitous in the Sienese Pliocene and sharks. Nor is it true that it is the first Italian palaeontological work in which binomial nomenclature was used, as sometimes claimed.

  10. On the influence of advection on the "Guardia dei Lombardi" geothermal field

    NASA Astrophysics Data System (ADS)

    Ebigbo, Anozie; Niederau, Jan; Marquart, Gabriele; Gola, Gianluca; Inversi, Barbara; Scrocca, Davide; Manzella, Adele; Montegrossi, Giordano

    2014-05-01

    Due to local specific-heat-flow maxima of up to 90 mW/m2 and temperatures of about 100 °C at less than 1.7 km depth, a southern Italian (Province of Avelino) carbonate reservoir is being explored as a medium-enthalpy geothermal resource. Hydrocarbon exploration wells and several seismic profiles within the chosen area (with dimensions of 43 x 28 km) provide the basis for a complex, three-dimensional geological model. The reservoir is faulted, anticlinal in structure, and overlain by dense, partly clay-rich sedimentary layers. A hydraulic and thermal characterisation of the geological units is possible through a combination of laboratory measurements, literature sources, and well log data. Under the assumption of purely conductive heat transport, the specific heat flow at the bottom of the reservoir (at 6 km depth) can be estimated using temperature data from several boreholes in the region to 67 mW/m2 . The goal of this study is the investigation of advective flow and the evaluation of its influence on the temperature distribution in the reservoir. First hydrothermal simulation models show a complicated flow structure in the anticlinal reservoir. But an inversion for constant reservoir permeability based on the borehole-temperature observations results in a relatively low value of 0.5 to 1 mD. However, pointwise comparisons between modelled and measured temperatures show large differences. Thus, for an accurate inclusion of regional flow processes and thermal convection, a proper representation of the geometry of the anticlinal Apulian platform and a karstified, highly permeable layer at the interface between the reservoir and its sedimentary cover is necessary. Such a refined model will also lead to a recalibration of the specific basal heat flow.

  11. Draft Environmental Impact Statement - MX Deployment Area Selection and Land Withdrawal/Acquisition DEIS.

    DTIC Science & Technology

    1980-12-01

    deployment of 200 missiles in Texas /New Mexico, with OBs near Dalhart , Texas , and Clovis, New Mexico. Alternative 8 locates 100 missiles in Nevada/Utah, with...facility needs. Texas /New Mexico Student enrollments and teacher requirements will be steady or slowly rising in Clovis and Dalhart without M-X. M-X...PRESENTED IN CHAPTERS 3 AND 4 CHAPTER 3 AFFECTED ENVIRONMENT CHAPTER 3 DESCRIBES THE POTENTIALLY AFFECTED ENVIRONMENT IN NEVADA, UTAH, TEXAS , AND NEW MEXICO

  12. Environmental Impact Analysis Process. Deployment Area Selection and Land Withdrawal/Acquisition DEIS.

    DTIC Science & Technology

    1980-12-01

    Utah. Alternative 7 (see Figure 2) is deployment of 200 missiles in Texas /New Mexico, with OBs near Dalhart , Texas , and Clovis, New Mexico. Alternative 9...Milford, UT Coyote Spring Valley, NV 7. Texas /New 0 0 200 Clovis. NM Dalhart . TX Mexico Split Basing Alternative 8. Nevada/Utah- - 100 100 Coyote Spring...THE POTENTIALLY AFFECTED ENVIRONMENT IN NEVADA, UTAH, TEXAS , AND NEW MEXICO. ENVIRONMENTAL FEATURES OF BOTH I-STATE REGIONS AND OF OPERATING BASE

  13. La semantica dei colori: Aspetti teorici e analisi dei cromonimi in italiano e neerlandese (Semantics of Colors: Theoretical Aspects and Analysis of Names of Colors in Italian and Dutch).

    ERIC Educational Resources Information Center

    Ross, Delores

    1989-01-01

    Presents a review of the literature dealing with the theory of the naming of colors. A comparison is made between the names of colors in Italian and Dutch, discussing the differences between languages in terms of the influence of the sociocultural context. (61 references) (CFM)

  14. Per la valutazione dei libri di testo di italiano come lingua straniera (Evaluating Textbooks of Italian as a Foreign Language).

    ERIC Educational Resources Information Center

    Sivazliyan, S. Abbiati; Sullam, A. V. Calimani

    1988-01-01

    Discusses current research about the teaching of Italian as a foreign language. A form designed for the evaluation of textbooks for Italian as a foreign language is presented, and eight textbooks for the teaching of Italian as a foreign language are evaluated according to this form. (CFM)

  15. Environmental Impact Analysis Process. Deployment Area Selection and Land Withdrawal/Acquisition DEIS. Chapter III. Part I. Affected Environment.

    DTIC Science & Technology

    1980-12-01

    lands in the Texas/New Mexico study area. 3-326 3.3.3.8-1 Irrigated cropland in the Texas/New Mexico study area. 3-332 3.3.3.8-2 Dry cropland in the Texas...General> unsat ur ecu .eci. m4.e:.t.- re net. oer r i c r n; * nc !r’ .acustr,.ne Lake-bed ciav sIlI n C Pt’r-t a1 vnr’ cposits ; lva vOor: Ter F! ear...South 14 22 1 12 190 Cave 20 61 Dry Lake 3 28 M .92 Delamar 3 12 3 2 ’.3 Lake 17 1 19.2 None 184 Sprinq 70-i00 42 18 52 Hamlin NA 12 1.5 NA 202

  16. Draft Environmental Impact Statement. MX Deployment Area Selection and Land Withdrawal/Acquisition DEIS. Volume 3, Part II. Affected Environment.

    DTIC Science & Technology

    1980-12-01

    vicinity. 3-358 3.4.1.1-2 Historic and projected baseline labor force in Iron county. 3-359 3.4.1.1-3 Historic and projected baseline rate of...unemployment in Iron county. 3-360 3.4.1.1-4 Historic and projected baseline population in Iron county. 3-361 viii woo Figure Page 3.4.1.2-1 Vegetation cover...expenditures, Iron County, Utah, selected years 1977 and 1978 3-377 3.4.1.3-7 Summary of revenues, all funds Iron County School District, 1977-1978 3

  17. Environmental Impact Analysis Process. Deployment Area Selection and Land Withdrawal/Acquisition DEIS. Chapter III. Part II. Affected Environment.

    DTIC Science & Technology

    1980-12-01

    projected baseline labor force in Iron county. 3-359 3.4.1.1-3 Historic and projected baseline rate of unemployment in Iron county. 3-360 3.4.1.1-4...Historic and projected baseline population in Iron county. 3-361 viii -4, * ..,- _. . Figure Page 3.4.1.2-1 Vegetation cover types in the vicinity of...bonding capacities, 1979 3-376 3.4.1.3-6 General fund revenue and expenditures, Iron County, Utah, selected years 1977 and 1978 3-377 3.4.1.3-7 Summary

  18. Benthic Foraminifera as bio-indicators of anthropogenic impacts in coastal environments: Acqua dei Corsari area case study (Palermo, Italy).

    PubMed

    Musco, Marianna; Cuttitta, Angela; Bicchi, Erica; Quinci, Enza Maria; Sprovieri, Mario; Tranchida, Giorgio; Giaramita, Luigi; Traina, Anna; Salvagio Manta, Daniela; Gherardi, Serena; Mercurio, Pietro; Siragusa, Angelo; Mazzola, Salvatore

    2017-04-15

    This study investigates living benthic foraminiferal assemblages as bio-indicators of anthropogenic activities in a coastal area within the Gulf of Palermo (Sicily, Italy), affected by industrial and urban activities, and evaluates the environmental quality through the calibration of a Tolerant Species index (%TSstd). Sediments from 6 stations were sampled along a bathymetric transect from the coast to offshore. Sediment grain size, TOC, major, minor and trace elements and polycyclic aromatic hydrocarbons (PAHs) were compared to benthic foraminiferal assemblages and species at each station. Diversity and density of benthic foraminiferal assemblages were not affected by the presence of pollutants, while tolerant species increased with organic (TOC and PAHs) or chemical (As and Pb) concentrations. Moreover, the calibration of the %TSstd formula to >125μm foraminiferal assemblage, gives a detailed description of environmental quality along the transect, representing a good and sensitive tool to evaluate marine coastal environment.

  19. Lettura, Scrittura e Analisi dei Grafemi in Prima Elementare (Reading, Writing and Grapheme Analysis in First Grade)

    ERIC Educational Resources Information Center

    Deva, Ferruccio

    1977-01-01

    This article discusses an aspect of the process of learning to read and write which has received little attention, that is, the ability of children to recognize and to distinguish clearly the sounds which correspond to the individual letters within each word. (Text is in Italian.) (CFM)

  20. Environmental Impact Analysis Process. Deployment Area Selection and Land Withdrawal/Acquisition DEIS. Chapter I. Program Overview.

    DTIC Science & Technology

    1980-12-01

    AC-AIO8 616 DEPARTMET OF THE AIR FORCE WASHZINOTON DC F/0 16/1 ENVIRONMENTAL IMPACT ANALYSIS PROCESS. DEPLOYMENT AREA SELECTIO--ETCIU) UNIEAEEEDhh EE...CD 0 E 0 1-31 DEPARTMENT OF THE AIR FORCE WASHINGTON 20330 OFFICE OF THE ASSISTANT SECRETARY December 1, 1980 TO: Governmental Agencies, Public Groups...ATTN: AFRCE-MX/DEV Box EIS Norton Air Force Base, California 92409 Sincerely, Principal Deputy Assistant Secretary of the Air Force (Manpower, Reserve

  1. 77 FR 15087 - Intent To Prepare a Draft Environmental Impact Statement (DEIS) for the Installation of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-14

    ...) for the Installation of a Terminal Groin Structure at the Western End of South Beach, Bald Head Island... develop and implement a shoreline protection plan that includes the installation of a terminal groin... the Village of Bald Head Island Terminal Groin Project. SUPPLEMENTARY INFORMATION: 1....

  2. Draft Environmental Impact Statement. MX Deployment Area Selection and Land Withdrawal/Acquisition DEIS. Volume II. Comparative Analysis of Alternatives.

    DTIC Science & Technology

    1980-12-01

    1987 1988 1989 NUMBER CLUSTERS 1 10 - 6 17 - 7 14 8 9 m 5 10 - - 4 15 - 3 13 U 2 12 2015 A Figure 2.2-7. DDA construction schedule for portion of...34 & . .. . , ,-’ £ £ C’" " .o’r I - 1 NO SIGNIFICANT IMPACT LOVVIGNIF ICANCE MO0 RAT SKNit IGANCE 14U ’W( NIf WANTI)MPAf I 3460 B .- -- ~ ° 4A"’ Fig

  3. 78 FR 2423 - Draft Environmental Impact Statement (DEIS) for the Proposed Shu'luuk Wind Project on the Campo...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-11

    ... Action Alternative, would achieve the generation of electricity from wind turbines installed by Invenergy. The manufacturer and model of the wind turbines have not yet been selected for the Shu'luuk Wind... temporary concrete batch plant. The wind power generation facility would operate year-round for a minimum...

  4. 75 FR 7452 - Intent To Prepare a Draft Environmental Impact Statement (DEIS) for the State of Alaska's...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-19

    ...) for the State of Alaska's Proposed Alaska Stand Alone Pipeline (ASAP) Natural Gas Transportation Pipeline AGENCY: U.S. Army Corps of Engineers, DoD. ACTION: Notice of Intent; Extension of scoping period. SUMMARY: In December 4, 2009, issue of the Federal Register (74 FR 63736), the Alaska District, U.S....

  5. 75 FR 12735 - Draft Environmental Impact Statement (DEIS) for Resumption of Year-Round Firing Opportunities at...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-17

    ... potential environmental effects associated with the U.S. Army Alaska (USARAK) proposal to strengthen unit... Richardson. Current restrictions cause a shortage of live-fire training opportunities at Fort Richardson... the current ``winter only'' firing regimen. These restrictions are still in effect today and...

  6. Environmental Impact Analysis Process. Deployment Area Selection and Land Withdrawal/Acquisition DEIS. Chapter II. Comparative Analysis of Alternatives.

    DTIC Science & Technology

    1980-12-01

    retained their natural area designation. o Zeolite Deposits. Zeolites are minerals formed by alteration of pyro- clastic volcanic rocks. Certain types of... zeolites , those with fibrousIcrystalline habit similar to asbestos, are suspected of being cancer- causing. Identified areas of zeolite occurrence could...Texas/New Mexico split basing. 44,~ !.~ cow NALLAMGL CO I J1 DEADA SMIT .- .4 iAREAS 013 SUITABLITY AREAS SCONCEPTUAL LAYOUTS - 4-g

  7. 76 FR 60474 - Intent To Prepare a Draft Environmental Impact Statement (DEIS) for the Haile Gold Mine in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-29

    ... notice is available on Charleston District's public Web site at: http://www.sac.usace.army.mil/?action... open pit mining, and to construct associated facilities. The Haile Gold Mine Site encompasses approximately 4,231 acres. Mining will occur in phases involving eight open mining pits over a...

  8. Draft Environmental Impact Statement - MX Deployment Area Selection and Land Withdrawal/Acquisition DEIS. Volume V. Appendices.

    DTIC Science & Technology

    1980-12-01

    Resembling a tree in structure, growth, or appearance. Archaic Period Anthropological term indicating the oldest stage in the evolution of a...period to the present time, characterized by the rapid evolution of mammals, birds, grasses, shrubs, and higher flowering plants. Chaining A method to...Implications of plate tectonics for the Cenozoic tectonic evolution of western North America. Geological Society of America Bulletin 81:3,513-3,536

  9. Draft Environmental Impact Statement (DEIS) for the Closure (Withdrawal of Units) of Norton Air Force Base, California

    DTIC Science & Technology

    1989-11-01

    landscaped: little or no natural habitat remains. Landscaping on base includes a variety of shrubs and trees such as oleander , elm, mulberry, eucalyptus...grasses Malathion Mosquito larvae, aphids , fleas Sevin 80W Aphids Sevin Brown dog ticks Diazinon 4E Brown dog ticks, spiders Diquat Aquatic weeds Balan

  10. Draft Environmental Impact Statement. MX Deployment Area Selection and Land Withdrawal/Acquisition DEIS. Volume 3. Part 1. Affected Environment.

    DTIC Science & Technology

    1980-12-01

    northwest and west central (near Santa Rosa , New Mexico) portions, due to increasing topographic relief as well as decreasing aridity. The southwestern...3.3.2.8-2, respectively. Aquatic Species (3.3.2.8.3) Protected fish occur mostly in the Pecos River near Roswell, Fort Sumner, and Santa Rosa , in the...National Park Service holding is the Lake Meredith National Recreational Area. The Kiowa and Rita Blanca National Grasslands are administered by the U.S

  11. 78 FR 63169 - Intent To Prepare a Draft Environmental Impact Statement (DEIS) for the Navy Base Intermodal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-23

    ... contact the Corps, Charleston District Corporate Communication ] Officer (CCO), Ms. Glenn Jeffries by... beginning at 5:30 p.m. EDT at the Chicora School of Communications, 3795 Spruill Avenue, North...

  12. 76 FR 28005 - Draft Environmental Impact Statement (DEIS) for Training Land Expansion at Fort Benning, GA and AL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-13

    ... Benning, GA and AL AGENCY: Department of the Army, DoD. ACTION: Notice of Availability (NOA). SUMMARY: The... comment period will end 45 days after publication of the ] NOA in the Federal Register by the...

  13. Draft Environmental Impact Statement. MX Deployment Area Selection and Land Withdrawal/Acquisition DEIS. Volume IV. Part II. Environmental Consequences to the Study Regions and Operating Base Vicinities.

    DTIC Science & Technology

    1980-12-01

    163 4.3.1.8-2 Relationship between bighorn sheep range and the Coyote Spring Valley operating base location. 4-167 4.3.1.8-3 Bighorn sheep range and...249 4.3.1.10-4 Relationship between wilderness areas and Alternative 8 project activities, Texas/New Mexico. 4-251 4.3,2.1-1 Nevada/Utah region of...sensi- tivity in the vicinity of the Ely, Nevada OB. 4-740 4.3.2.14-7 Relationship between areas of high archaeological and historical senstivity

  14. Constraining the Age of the Veritas Asteroid Break-Up Event with Helium-3 from the Tortonian Monte Dei Corvi Section in Italy

    NASA Astrophysics Data System (ADS)

    Meier, M. M. M.; Maden, C.; Busemann, H.

    2016-08-01

    We have measured the He and Ne in the stratigraphic reference section of the Tortonian, encompassing the Veritas break-up event ca. 8 Ma ago. We find a clear extraterrestrial He peak and can thus constrain the age of that event to 8.07-8.25 Ma ago.

  15. Draft Environmental Impact Statement. MX Deployment Area Selection and Land Withdrawal/Acquisition DEIS. Volume IV. Part I. Environmental Consequences to the Study Regions and Operating Base Vicinities.

    DTIC Science & Technology

    1980-12-01

    LENVIRONMENT RESOURCES/ HUMAN - ENVIROMENT RESOURCES 4 /l E/ kraCEUNG PILLE BLAM 4T fl"-M Fig 4.1-2 SUMMARY COMPARISON OF LON BETWEEN THE PROPOSED...ALTERNATIVES 1 𔃼 MONMENT RESOURCES/ HUMAN ENVIROMENT RESOURCES A x ~ ’ 7 /& fr/’ 9 / C,~0 c5,YjC~ E N 1’o1[ H AN T M;’, I MEII I A IljNll A,,( ( MOO A...SPECKL ED DACE (F) UTAH OR SNAKE VALLEY CUTTHROAT TROUT (R) VIRGIN SPINEDACE RECOMMENDED PROTECTED INVERTEBRATES MOLLUSCS 19 OVERTON ASSIMINEA 20 MOAPA

  16. Sull' Applicazione di Paradigmi della Linguistica alla Theoria dei Testi Letterari (On the Application of Linguistic Paradigms to Literary Text Theory).

    ERIC Educational Resources Information Center

    Fasoli, Paolo

    1992-01-01

    Summarizes trends over the last century of analyzing literature (poetry and prose) through the aid of linguistic theory. The contributions and shortcomings of various schools (Structuralist, Danish, Formalist, Transformationalist, Generativist) to the evaluation of literature are briefly outlined. (LET)

  17. Draft Environmental Impact Statement. MX Deployment Area Selection and Land Withdrawal/Acquisition DEIS. Volume 4, Part III. Environmental Consequences to the Study Regions and Operating Base Vicinities.

    DTIC Science & Technology

    1980-12-01

    2 - - - - 182 Delamar - - 183 Lake - - - - 184 Spring - - - - 196 Hamlin - - - - 202 Patterson - - 207 Whit’ River 98 0.3 L 61 0.2" 208 Pahroc...20 0,1 202 Patterson - - - - 207 White River 98 0.3 61 3.2 208 Pahroc - - - - 209 Pahranagat 98 3.1 61 1,9 Bailey. TX 458 0.1 286 0.06 Cochran. TX... River 7 0.09 4 0.09 208 Pahroc - - - - 209 Pahranagat - - - overall DDA 180- 0.09 113 1 o0.06 1i 3885-2 fl 7None. (No cropland disturbed.) 7- Low to

  18. Environmental Impact Analysis Process. Deployment Area Selection and Land Withdrawal/Acquisition DEIS. Chapter IV. Part III. Environmental Consequences to the Study Regions and Operating Base Vicinities.

    DTIC Science & Technology

    1980-12-01

    Delmar - - 183 Lake . ’ I 184 Spring ... .- ! 196 Hamlin - - 202 Patterson - - 207 Whit River 98 0.3 61 0.2’ 208 Pahroc - - - - 209 Pahranagat 98 3.1 1 61...207 White River 98 0.3 61 0.2 208 Pahroc - - - - 209 Pahranaat 98 3.1 61 1.9 Bailey, T58 O1 286 0. Cochran, TX 1,537 0.3 959 0.2 Dallam, TX...Spring - - - - 196 Hamlin . .. . 202 Patterson - - - - 207 White River 7 0.09 4 0.09 208 Pahroc - - - - 209 Pahranagat - - - - Overall DDA 180 0.09 = F

  19. Determination and Analysis of the main physical parameters of the asteroid (2717) Tellervo. (Italian Title: Determinazione ed Analisi dei principali parametri fisici dell'asteroide (2717) Tellervo)

    NASA Astrophysics Data System (ADS)

    Tomassini, A.; Scardella, M.; Lacaprara, G.

    2013-02-01

    The "ATA Research Group" has undertaken an observation campaign (started at the end of 2011 with several preliminary sessions) oriented to little-known asteroids main properties determination (synodic period, size, possible taxonomic class). This study has been focused on the asteroid (2717) Tellervo belonging to the Main Belt. This work would be an example and an incentive to other non-professional Association to develop a field where the amateur Astronomers can provide a remarkable role to the knowledge of these more and more interesting Solar System objects.

  20. Environmental Impact Analysis Process. Deployment Area Selection and Land Withdrawal/Acquisition DEIS. Chapter IV. Part II. Environmental Consequences to the Study Regions and Operating Base Vicinities.

    DTIC Science & Technology

    1980-12-01

    windmills (green), and irrigated agriculture (bright red field patterns). 4-55 4.3.1.1-18 Dalhart , Texas , potential OB zones with water- courses (blue) and...for Alternative 7. 4-133 4.3.1.6-7 Pronghorn antelope in the vicinity of the Dalhart , Texas OB. 4-137 4.3.1.6-8 Pronghorn range for Alternative 8...in the vicinity of the operating base near Dalhart , Texas . 4-596 4.3.2.11-10 Private land and split basing, Nevada/Utah. 4-597 4.3.2.11-11 Private

  1. 76 FR 35915 - Proposed Information Collection Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-20

    ... concerning the proposed collection of information for the Evaluation of the Employment and Training... each DEI site participate in the Ticket to Work program as an Employment Network; and (5) plan for... the DEI evaluation is to understand and assess DEI program start-up and implementation, DEI...

  2. 76 FR 5203 - Draft Environmental Impact Statement, Stehekin River Corridor Implementation Plan, North Cascades...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-28

    ... Environmental Impact Statement (Plan/DEIS). The Plan/DEIS evaluates four alternatives for sustainable management of NPS facilities (e.g. roads, maintenance yard, trails, bridges) in response to flooding and...

  3. 78 FR 55763 - National Environmental Policy Act; Santa Susana Field Laboratory

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-11

    ... of Availability (NOA) for the DEIS for Demolition and Cleanup Activities for the NASA-administered... NOA of the DEIS in the Federal Register on the same day (August 2, 2013, Vol. 78, No. 149, pages...

  4. Radiologist Evaluation of an X-ray Tube Based Diffraction Enhanced Imaging Prototype Using Full Thickness Breast Specimens.

    SciTech Connect

    Faulconer, L.; Zhong, Z.; Parham, C.; Connor, D. M.; , Kim, E.; Zeng, D.; Livasy, C.; Cole, E.; Kuzmiak, C.; Koomen, M.; Pavic, D.; Pisano, E.

    2009-05-21

    Conventional mammographic image contrast is derived from x-ray absorption, resulting in breast structure visualization due to density gradients that attenuate radiation without distinction between transmitted, scattered, or refracted x-rays. Diffraction-enhanced imaging (DEI) allows for increased contrast with decreased radiation dose compared to conventional mammographic imaging because of monochromatic x-rays, its unique refraction-based contrast mechanism, and excellent scatter rejection. However, a lingering drawback to the clinical translation of DEI has been the requirement for synchrotron radiation. The authors laboratory developed a DEI prototype (DEI-PR) using a readily available tungsten x-ray tube source and traditional DEI crystal optics, providing soft tissue images at 60 keV. Images of full-thickness human breast tissue specimens were acquired on synchrotron-based DEI (DEI-SR), DEI-PR, and digital mammographic systems. A panel of expert radiologists evaluated lesion feature visibility and correlation with pathology after receiving training on the interpretation of refraction contrast mammographic images. For mammographic features (mass, calcification), no significant differences were detected between the DEI-SR and DEI-PR systems. Benign lesions were perceived as better seen by radiologists using the DEI-SR system than the DEI-PR system at the [111] reflectivity, with generalizations limited by small sample size. No significant differences between DEI-SR and DEI-PR were detected for any other lesion type (atypical, cancer) at either crystal reflectivity. Thus, except for benign lesion characterizations, the DEI-PR system's performance was roughly equivalent to that of the traditional DEI system, demonstrating a significant step toward clinical translation of this modality for breast cancer applications.

  5. Bisogni linguistici dei discenti di italiano alla scuola di lingua e cultura italiana per stranieri di Siena (Linguistic Needs of Students of Italian at the School of Italian Language and Culture for Foreigners of Siena).

    ERIC Educational Resources Information Center

    Maggini, Massimo; Parigi, Valerio

    1986-01-01

    Presents the results of a questionnaire administered to students of Italian at the School for Foreigners of Siena to determine the following: (1) student characteristics; (2) student motivations for studying Italian; (3) student interests; (4) student linguistic needs; and (5) student evaluation of the program. (CFM)

  6. Comparative Evaluation of ERASMUS ICPs in the Subject Areas of Business Management, Chemistry and History. ERAMUS Monographs No 8 = Valutazione Comparata dei pic ERASMUS nelle Aree Disciplinari dell'Organizzazione Aziendale, della Chimica e della Storia. Monografie ERASMUS No. 8.

    ERIC Educational Resources Information Center

    Monasta, Attilio

    This report presents results from one of several research studies involving the European Community Action Scheme for the Mobility of University Students (ERASMUS), one of the inter-university cooperation programs initiated by the Commission of European Communities. It is noted that ERASMUS, as well as the other inter-university cooperation…

  7. Cigarette smoking and acute myocardial infarction. A case-control study from the GISSI-2 trial. GISSI-EFRIM Investigators. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto--Epidemiologia dei Fattori di Rischio dell'infarto Miocardioco.

    PubMed

    Negri, E; La Vecchia, C; Nobili, A; D'Avanzo, B; Bechi, S

    1994-08-01

    To make a further quantitative assessment of the relationship between cigarette smoking and the risk of myocardial infarction, a multicentric case-control study was conducted in Italy between September 1988 and June 1989 within the framework of the GISSI-2 trial. Ninety hospitals in various Italian Regions participated. 916 cases of acute myocardial infarction with no history of ischaemic heart disease and 1106 controls admitted to hospital for acute conditions not related to known or suspected risk factors for ischaemic heart disease were studied. Relative risks (RR) and 95% confidence intervals (CI) of myocardial infarction according to various measures of tobacco smoking, were adjusted for identified potential confounding factors using multiple logistic regression. Compared to lifelong non-smokers, the RR was 1.3 (95% CI 1.0 to 1.9) for ex-smokers, 2.0 (95% CI 1.4 to 2.9) for current smokers of less than 15 cigarettes per day, 3.1 (95% CI 2.2 to 4.2) for 15-24 cigarettes per day and 4.9 (95% CI 3.4 to 7.1) for 25 or more cigarettes per day. No trend in risk was evident for the duration, the RR being around 3 for subsequent categories. There was a significant interaction between smoking and age. Below the age 45, smokers of 25 or more cigarettes per day had a 33 times higher risk than non-smokers, compared to 7.5 at in the age group 45-54, 4.4 between the ages 55-64 and 2.5 at the age of 65 or over. The risk estimates were higher in women (RR for > or = 25 cigarettes per day = 10.1), in subjects in the lowest cholesterol tertile (RR = 11.9), with no history of diabetes (RR = 6.8), hypertension (RR = 9.5), no family history ischaemic heart disease (RR = 9.1) and low body mass index (RR = 9.3). The importance of smoking is confirmed as a cause of acute myocardial infarction: about 50% of all nonfatal infarctions in this Italian population could be attributable to cigarette smoking.(ABSTRACT TRUNCATED AT 250 WORDS)

  8. Frequency of consumption of selected indicator foods and serum cholesterol. GISSI-EFRIM investigators. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto--Epidemiologia dei Fattori di Rischio dell'Infarto Miocardico.

    PubMed

    D'Avanzo, B; Negri, E; Nobili, A; La Vecchia, C

    1995-06-01

    The relationship between frequency of consumption of eleven indicator foods (milk, meat, liver, carrots, green vegetables, fruit, eggs, ham, fish, cheese and alcohol) and serum cholesterol was investigated in the comparison group of a case-control study of acute myocardial infarction conducted in Italy. Data were collected on 792 subjects from various Italian regions, admitted to hospital for acute conditions unrelated to any known or potential risk factor for myocardial infarction or to long-term modifications in diet. No statistically or epidemiologically meaningful relationship emerged between serum cholesterol level and frequency of consumption of any of these foods. Cholesterol levels rose according to increasing consumption tertiles for most of the indicator foods considered. Higher values for the higher tertile of consumption were observed for meat, ham and eggs, but also for fruit, carrots and green vegetables. However, correlation coefficients between frequency of consumption of various food items and serum cholesterol level were uniformly low for all food items considered, ranging between -0.09 (for milk) and 0.19 (for ham). Although a more comprehensive diet history may lead to different indications, the present data are not suggestive of any major influence of long-term frequency of consumption of a few selected indicator foods on serum cholesterol levels.

  9. Physical activity and the risk of acute myocardial infarction. GISSI-EFRIM Investigators. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto-Epidemiologia dei Fattori di Rischio dell'Infarto Miocardico.

    PubMed

    D'Avanzo, B; Santoro, L; La Vecchia, C; Maggioni, A; Nobili, A; Iacuitti, G; Franceschi, S

    1993-11-01

    The relationship between physical activity and acute myocardial infarction (AMI) was examined in a case-control study conducted in Italy in 1988 to 1989 within the framework of the GISSI-2 trial of streptokinase versus alteplase and heparin versus no heparin in the treatment of AMI. A total of 916 case patients admitted to coronary care units from various Italian regions for AMI were interviewed. Control subjects were 1106 patients admitted to the same network of hospitals for a broad spectrum of acute diseases not related to known or potential risk factors for myocardial infarction. Among various types of physical activity (occupational activity, walking, stair climbing, and sport and leisure-time physical activity), occupational physical exercise emerged as the most protective. Multivariate odds ratios (ORs) were 1.4 (95% confidence interval (CI), 1.0 to 2.0) and 1.6 (95% CI, 1.2 to 2.1) for the two lowest levels of occupational physical activity. The trends of increasing risk with decreasing activity were consistent, although less strong, when other types of activity were considered. The protection conveyed by occupational physical activity was similar across various strata of sex, age, education, smoking habits, and diabetes, and was not explained by serum cholesterol, body weight, or hypertension. This study therefore confirms that low physical activity is an indicator of subsequent risk of AMI.

  10. Coffee consumption and risk of acute myocardial infarction in Italian males. GISSI-EFRIM. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto, Epidemiologia dei Fattori di Rischio del'Infarto Miocardico.

    PubMed

    D'Avanzo, B; La Vecchia, C; Tognoni, G; Franceschi, S; Franzosi, M G; Nobili, A; Santoro, L; Scarsi, G

    1993-11-01

    The relationship between coffee consumption and acute myocardial infarction (AMI) was analyzed using data from a case-control study conducted in 1988 to 1989 within the framework of the GISSI-2 trial on streptokinase versus alteplase and heparin versus no heparin in the treatment of AMI. A total of 801 male patients with AMI and 792 control subjects who were hospitalized in several Italian regions for diseases unrelated to known or potential risk factors for cardiovascular diseases were included. Compared with coffee nondrinkers, the multivariate relative risks (RRs), after allowance for age, education, body mass index, smoking habits, alcohol consumption, family history of AMI, cholesterol level, history of diabetes, and hypertension, were 0.8 (95% confidence interval (CI), 0.5 to 1.2) for consumption of one cup/d, 1.3 (95% CI, 0.9 to 2.0) for two cups/d, 1.8 (95% CI, 1.1 to 2.7) for three cups, 2.5 (95% CI, 1.5 to 4.1) for four cups, and 2.6 (95% CI, 1.6 to 4.2) for five cups or more. The trend in risk with dose was statistically significant (P < 0.001). Duration of coffee consumption was not associated with the risk of AMI. The RRs for daily coffee consumption were elevated across strata of various covariates, including age, smoking habits, cholesterol level, diabetes, and hypertension, with a particularly elevated (although not significantly heterogeneous) estimate in patients younger than 50 years (RR, 5.7; 95% CI, 3.0 to 10.9 for four or more cups/d). The RR in patients who drank four or more cups of coffee per day and were current smokers was 8.1 (95% CI, 5.1 to 13.0), suggesting an unfavorable effect on the combination of cigarette smoking and high coffee intake on the risk of AMI.

  11. In para totale...una cosa da panico...sulla lingua dei giovani in Italia (In para totale...una cosa da panico...The Language of Young People in Italy).

    ERIC Educational Resources Information Center

    Marcato, Carla

    1997-01-01

    Describes and analyzes the language of young people in Italy today. Particular focus is on the expressions using "para" (e.g., "in para totale" = to be very bored or worried) and the phrase "una cosa da panico" (something terrible or its opposite something wonderful). (CFM)

  12. X-ray tube-based diffraction enhanced imaging prototype images of full-thickness breast specimens: reader study evaluation

    NASA Astrophysics Data System (ADS)

    Faulconer, L. S.; Parham, C.; Connor, D. J.; Koomen, M.; Kuzmiak, C.; Pavic, D.; Livasy, C. A.; Kim, E.; Zeng, D.; Cole, E. B.; Zhong, Z.; Pisano, E. D.

    2009-02-01

    Conventional mammographic image contrast is derived from x-ray absorption, resulting in breast structure visualization due to density gradients that attenuate radiation without distinction between transmitted and scattered or refracted x-rays. This leads to image blurring and contrast reduction, hindering the early detection of small or otherwise occult cancers. Diffraction enhanced imaging (DEI) allows for dramatically increased contrast with decreased radiation dose compared to conventional mammographic imaging due to monochromatic x-rays, its unique refraction-based contrast mechanism and excellent scatter rejection. However, a lingering drawback to the clinical translation of DEI has been the requirement for synchrotron radiation. Our laboratory developed a DEI prototype (DEI-PR) utilizing a readily available Tungsten xray tube source and traditional DEI crystal optics, providing soft tissue images at 60keV. To demonstrate the clinical utility of our DEI-PR, we acquired images of full-thickness human breast tissue specimens on synchrotron-based DEI, DEI-PR and digital mammography systems. A reader study was designed to allow unbiased assessment of system performance when analyzing three systems with dissimilar imaging parameters and requiring analysis of images unfamiliar to radiologists. A panel of expert radiologists evaluated lesion feature visibility and histopathology correlation after receiving training on the interpretation of refraction contrast mammographic images. Preliminary data analysis suggests that our DEI system performed roughly equivalently with the traditional DEI system, demonstrating a significant step toward clinical translation of this modality for breast cancer applications.

  13. SNTP environmental, safety, and health

    NASA Technical Reports Server (NTRS)

    Harmon, Charles D.

    1993-01-01

    Viewgraphs on space nuclear thermal propulsion (SNTP) environmental, safety, and health are presented. Topics covered include: program safety policy; program safety policies; and DEIS public hearing comments.

  14. 75 FR 27708 - Stanford University Habitat Conservation Plan

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-18

    ... INTERIOR Fish and Wildlife Service RIN 0648-XV36 Stanford University Habitat Conservation Plan AGENCIES... University Habitat Conservation Plan (Plan), the Draft Environmental Impact Statement (DEIS)...

  15. Aircraft Flutter Testing

    NASA Technical Reports Server (NTRS)

    1997-01-01

    Wilmer Reed gained international recognition for his innovative research, contributions and patented ideas relating to flutter and aeroelasticity of aerospace vehicles at Langley Research Center. In the early 1980's, Reed retired from Langley and joined the engineering staff of Dynamic Engineering Inc. While at DEI, Reed conceived and patented the DEI Flutter Exciter, now used world-wide in flight flutter testing of new or modified aircraft designs. When activated, the DEI Flutter Exciter alternately deflects the airstream upward and downward in a rapid manner, creating a force similar to that produced by an oscillating trailing edge flap. The DEI Flutter Exciter is readily adaptable to a variety of aircraft.

  16. Metabolism

    MedlinePlus

    ... El metabolismo Metabolism Basics Our bodies get the energy they need from food through metabolism, the chemical ... that convert the fuel from food into the energy needed to do everything from moving to thinking ...

  17. [Levels of trace elements in the fruits and vegetables from the so-called Land of fires in Campania Region (Southern Italy)].

    PubMed

    Esposito, Mauro; Cavallo, Stefania; Rosato, Guido; Chiaravalle, Eugenio; Miedico, Oto; Pellicanò, Roberta; Soprano, Vittorio; Baldi, Loredana

    2016-01-01

    INTRODUZIONE: una vasta area compresa tra le province di Napoli e Caserta nella regione Campania ha negli ultimi anni attirato l'attenzione dei mass media a causa degli interramenti illeciti di rifiuti di varia origine nei campi o del loro abbandono lungo le strade. A tali pratiche illecite si aggiunge il fenomeno dei roghi incontrollati di questo materiale, motivo per il quale la zona è stata soprannominata "Terra dei fuochi". OBIETTIVI: ricerca di elementi in tracce presenti nei prodotti alimentari di origine vegetale prodotti nella Terra dei fuochi. DISEGNO E SETTING: piano di monitoraggio per il rilevamento dei livelli di alcuni metalli tossici ed essenziali nei vegetali coltivati in Campania nella Terra dei fuochi. La determinazione dei microelementi è stata effettuata dopo mineralizzazione della sostanza organica mediante microonde, utilizzando la spettrometria di massa a plasma induttivamente accoppiato (ICP-MS). RISULTATI: durante l'attività di monitoraggio sono stati raccolti 65 campioni di ortaggi e 49 campioni di frutta in 43 comuni rientranti nella Terra dei fuochi. Il contenuto medio di metalli tossici, cadmio e piombo nei prodotti ortofrutticoli è risultato ben lontano dai limiti massimi fissati dalla normativa europea. I valori delle concentrazioni sono significativamente inferiori rispetto a quanto riscontrato in zone ad alto impatto ambientale a causa della presenza di impianti industriali. CONCLUSIONI: la presenza di elementi tossici o potenzialmente tali nei campioni vegetali prodotti nella Terra dei fuochi è attribuibile a una varietà di fattori ambientali rilevanti (caratteristiche geologiche dell'area, inquinamento del suolo, dell'atmosfera e delle acque di irrigazione, pratiche illecite di smaltimento dei rifiuti industriali); non sembra, tuttavia, sussistere un rischio per la salute dei consumatori. Resta comunque l'allerta per la loro presenza nell'ambiente e la necessità che le attività di monitoraggio continuino.

  18. 78 FR 15007 - Notice of Open House-Draft Environmental Impact Statement for Revised Water Control Manuals for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-08

    ... given that the U.S. Army Corps of Engineers, Mobile District (USACE), will conduct open house style... writing to: Commander, U.S. Army Corps of Engineers, Mobile District, Attn: PD-EI (ACT-DEIS), P.O. Box 2288, Mobile AL 36628. A limited number of CD copies will also be available at the DEIS open...

  19. Arrowwood National Wildlife Refuge: Draft environmental impact statement

    SciTech Connect

    1996-03-01

    This draft environmental impact statement (DEIS) analyzes the need to provide Arrowhead National Wildlife Refuge with water management capacity to mitigate for past restriction on water management capacity imposed by Jamestown Reservoir. This DEIS presents an incremental series of actions that could provide varying levels of this capacity. The preferred alternative is the Mud and Jim Lakes Bypass- Lower JUP Alternative.

  20. 78 FR 77657 - Fisheries of the Caribbean, Gulf of Mexico, and South Atlantic; Amendment 40 to the Fishery...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-24

    ... (DEIS); scoping; request for comments. SUMMARY: NMFS, Southeast Region, in collaboration with the Gulf.... NMFS, in collaboration with the Council, will develop a DEIS to describe and analyze alternatives to... NOAA's Administrative Order 216-6, Section 5.02(c), Scoping Process, NMFS, in collaboration with...

  1. Algunos Resumenes

    NASA Astrophysics Data System (ADS)

    1980-12-01

    EI "Palomar Observatory Sky Survey" es un medio auxiliar bien conocido y ütil para los astronomos. Todo el cielo dei hemisferio Norte esta captado en lotografias, cuyas reproducciones se encuentran archivadas en las bibliotecas de casi todos los observatorios importantes dei mundo.

  2. Language Policy and Planning: The Case of Italian Sign Language

    ERIC Educational Resources Information Center

    Geraci, Carlo

    2012-01-01

    Italian Sign Language (LIS) is the name of the language used by the Italian Deaf community. The acronym LIS derives from Lingua italiana dei segni ("Italian language of signs"), although nowadays Italians refers to LIS as Lingua dei segni italiana, reflecting the more appropriate phrasing "Italian sign language." Historically,…

  3. Long term outcome of localized aggressive non-Hodgkin lymphoma treated with a short weekly chemotherapy regimen (doxorubicin, cyclophosphamide, bleomycin, vincristine, and prednisone) and involved field radiotherapy: result of a Gruppo Italiano Multiregionale per lo Studio dei Linfomi e Leucenie (GIMURELL) study.

    PubMed

    Cabras, Maria Giuseppina; Mamusa, Angela Maria; Vitolo, Umberto; Freilone R, Roberto; Dessalvi, Paolo; Orsucci, Lorella; Tonso, Anna; Levis, Alessandro; Liberati, Marina; Lay, Giancarlo; Angelucci, Emanuele

    2009-09-01

    Recently, management of limited stage diffuse large cell lymphoma (DLCL) is trending toward a low intensity chemotherapy approach. Since 1993 we have used a brief weekly (6 weeks) chemotherapy scheme (Doxorubicin, Cyclophosphamide, Bleomycin, Vincristine, and Prednisone = ACOP-B) followed by involved field radiotherapy in 207 consecutive patients with well defined localized DLCL without age limit (median 57 years, range 18-85). Treatment was completed as designed in 183 of 207 patients (88%). One hundred and ninety-nine patients (96%) achieved complete remission. At a median follow-up of 66 months 170 patients are alive (82%), 168 of them free of disease. Twenty-nine patients experienced relapse after achieving a complete remission. Kaplan-Meier, risk of relapse was 24% after 13 years. Thirty (14.5%) patients have died, 14 (6.8%) due to lymphoma progression, one due to regimen toxicity and 15 (7.2%) from other causes while remaining in complete remission. The probability of overall survival and event free survival at 13 years was 78% (95% CI 70-87%) and 63% (95% CI 50-75), respectively. Crude rate of secondary malignancy was 5.26 /1000 person-years. The ACOP-B regimen plus involved field radiotherapy is well tolerated both short and long term and is an effective chemotherapy scheme for very well defined limited stage aggressive non-Hodgkin lymphomas in all age categories.

  4. Dunkerque-Falklands: Due eventi storico-politici attraverso l'analisi linguistica dei discorsi di Winston Churchill e Margaret Thatcher (Dunkirk-Falklands: Two Historical-Political Events through the Linguistic Analysis of the Speeches of Winston Churchill and Margaret Thatcher).

    ERIC Educational Resources Information Center

    Arcaini, Giovanna

    1988-01-01

    The political speech is a unique kind of document that reflects the socio-historic climate of its time. Two historical events (Dunkirk and the Falkland Islands Crisis) and a principal protagonist from each are discussed, and the speeches of these two individuals are analyzed in order to find similarities and differences, and to find their basic…

  5. Characterization of Diffraction-Enhanced Imaging

    SciTech Connect

    Kao, T.; Connor, D; Dilmanian, F; Faulconer, L; Liu, T; Parham, C; Pisano, E; Zhong, Z

    2009-01-01

    Diffraction-enhanced imaging (DEI) is a new x-ray imaging modality that has been shown to enhance contrast between normal and cancerous breast tissues. In this study, diffraction-enhanced imaging in computed tomography (DEI-CT) mode was used to quantitatively characterize the refraction contrasts of the organized structures associated with invasive human breast cancer. Using a high-sensitivity Si (3 3 3) reflection, the individual features of breast cancer, including masses, calcifications and spiculations, were observed. DEI-CT yields 14, 5 and 7 times higher CT numbers and 10, 9 and 6 times higher signal-to-noise ratios (SNR) for masses, calcifications and spiculations, respectively, as compared to conventional CT of the same specimen performed using the same detector, x-ray energy and dose. Furthermore, DEI-CT at ten times lower dose yields better SNR than conventional CT. In light of the recent development of a compact DEI prototype using an x-ray tube as its source, these results, acquired at a clinically relevant x-ray energy for which a pre-clinical DEI prototype currently exists, suggest the potential of clinical implementation of mammography with DEI-CT to provide high-contrast, high-resolution images of breast cancer (Parham 2006 PhD Dissertation University of North Carolina at Chapel Hill).

  6. Effect of Breast Compression on Lesion Characteristic Visibility with Diffraction-Enhanced Imaging

    SciTech Connect

    Faulconer, L.; Parham, C; Connor, D; Kuzmiak, C; Koomen, M; Lee, Y; Cho, K; Rafoth, J; Livasy, C; et al.

    2010-01-01

    Conventional mammography can not distinguish between transmitted, scattered, or refracted x-rays, thus requiring breast compression to decrease tissue depth and separate overlapping structures. Diffraction-enhanced imaging (DEI) uses monochromatic x-rays and perfect crystal diffraction to generate images with contrast based on absorption, refraction, or scatter. Because DEI possesses inherently superior contrast mechanisms, the current study assesses the effect of breast compression on lesion characteristic visibility with DEI imaging of breast specimens. Eleven breast tissue specimens, containing a total of 21 regions of interest, were imaged by DEI uncompressed, half-compressed, or fully compressed. A fully compressed DEI image was displayed on a soft-copy mammography review workstation, next to a DEI image acquired with reduced compression, maintaining all other imaging parameters. Five breast imaging radiologists scored image quality metrics considering known lesion pathology, ranking their findings on a 7-point Likert scale. When fully compressed DEI images were compared to those acquired with approximately a 25% difference in tissue thickness, there was no difference in scoring of lesion feature visibility. For fully compressed DEI images compared to those acquired with approximately a 50% difference in tissue thickness, across the five readers, there was a difference in scoring of lesion feature visibility. The scores for this difference in tissue thickness were significantly different at one rocking curve position and for benign lesion characterizations. These results should be verified in a larger study because when evaluating the radiologist scores overall, we detected a significant difference between the scores reported by the five radiologists. Reducing the need for breast compression might increase patient comfort during mammography. Our results suggest that DEI may allow a reduction in compression without substantially compromising clinical image

  7. Design and Implementation of a Compact Low-Dose Diffraction Enhanced Medical Imaging System

    SciTech Connect

    Parham, C.; Zhong, Z; Connor, D; Chapman, D; Pisano, E

    2009-01-01

    This paper describes the design, construction, and performance of a new DEI system using a commercially available tungsten anode x-ray tube and includes the first high-quality low-dose diffraction-enhanced images of full-thickness human tissue specimens. Diffraction-enhanced imaging (DEI) is a new x-ray imaging modality that differs from conventional radiography in its use of three physical mechanisms to generate contrast. DEI is able to generate contrast from x-ray absorption, refraction, and ultra-small-angle scatter rejection (extinction) to produce high-contrast images with a much lower radiation dose compared to conventional radiography.

  8. An improvement to the diffraction-enhanced imaging method that permits imaging of dynamic systems

    NASA Astrophysics Data System (ADS)

    Siu, K. K. W.; Kitchen, M. J.; Pavlov, K. M.; Gillam, J. E.; Lewis, R. A.; Uesugi, K.; Yagi, N.

    2005-08-01

    We present an improvement to the diffraction-enhanced imaging (DEI) method that permits imaging of moving samples or other dynamic systems in real time. The method relies on the use of a thin Bragg analyzer crystal and simultaneous acquisition of the multiple images necessary for the DEI reconstruction of the apparent absorption and refraction images. These images are conventionally acquired at multiple points on the reflectivity curve of an analyzer crystal which presents technical challenges and precludes imaging of moving subjects. We have demonstrated the potential of the technique by taking DEI "movies" of an artificially moving mouse leg joint, acquired at the Biomedical Imaging Centre at SPring-8, Japan.

  9. Digitally Enhanced Heterodyne Interferometry

    NASA Technical Reports Server (NTRS)

    Shaddock, Daniel; Ware, Brent; Lay, Oliver; Dubovitsky, Serge

    2010-01-01

    Spurious interference limits the performance of many interferometric measurements. Digitally enhanced interferometry (DEI) improves measurement sensitivity by augmenting conventional heterodyne interferometry with pseudo-random noise (PRN) code phase modulation. DEI effectively changes the measurement problem from one of hardware (optics, electronics), which may deteriorate over time, to one of software (modulation, digital signal processing), which does not. DEI isolates interferometric signals based on their delay. Interferometric signals are effectively time-tagged by phase-modulating the laser source with a PRN code. DEI improves measurement sensitivity by exploiting the autocorrelation properties of the PRN to isolate only the signal of interest and reject spurious interference. The properties of the PRN code determine the degree of isolation.

  10. 78 FR 31974 - Notice of Availability of the Draft Environmental Impact Statement and Notice of Public Meetings...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-28

    ... professional resource management and protection theories, concepts, and practices; and Be consistent with... Public Meetings for the Newlands Project Resource Management Plan AGENCY: Bureau of Reclamation, Interior... Draft Resource Management Plan (RMP)/Draft Environmental Impact Statement (DEIS) for the...

  11. Dioxin Exposure Initiative

    EPA Pesticide Factsheets

    The Dioxin Exposure Initiative (DEI) is no longer active. This page contains a summary of the dioxin exposure initiative with illustrations, contact and background information.Originally supported by scientist Matthew Lorber, who retired in Mar 2017.

  12. 49 CFR 520.3 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... the agency as part of any program or project proposal within the scope of activities listed in § 520.4... environmental impact statement. (c) Draft environmental impact statement (DEIS) means a preliminary statement...

  13. 76 FR 57022 - Coastal Zone Management Program: Illinois

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-15

    ... National Oceanic And Atmospheric Administration Coastal Zone Management Program: Illinois AGENCY: Office of Ocean and Coastal Resource Management (OCRM), National Oceanic and Atmospheric Administration (NOAA... Impact Statement (DEIS) prepared by NOAA's Office of Ocean and Coastal Resource Management. The...

  14. 49 CFR 520.27 - Legislative actions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Legislative actions. (a) A DEIS on both legislative proposals and reports for which NHTSA either develops the... the Office of Management and Budget through the normal DOT and NHTSA legislative process. (b)...

  15. 78 FR 70024 - Draft Environmental Impact Statement for the Modernization and Repair of Piers 2 and 3, Military...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-22

    ..., Military Ocean Terminal Concord, CA AGENCY: Department of the Army, DoD. ACTION: Notice of Availability... (DEIS) for the Modernization and Repair of Piers 2 and 3 at Military Ocean Terminal Concord (MOTCO)....

  16. 75 FR 21650 - Coral Reef Restoration Plan, Draft Programmatic Environmental Impact Statement, Biscayne National...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ... National Park Service Coral Reef Restoration Plan, Draft Programmatic Environmental Impact Statement... Availability of the Draft Programmatic Environmental Impact Statement for the Coral Reef Restoration Plan... Environmental Impact Statement (DEIS) for the Coral Reef Restoration Plan for Biscayne National Park,...

  17. 76 FR 59123 - Notice of Intent To Prepare a Draft Environmental Impact Statement for the Puyallup River General...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-23

    ... Electron Dam to Commencement Bay, the Carbon River and the White River downstream of Mud Mountain Dam. This... flank of Mount Rainier. The study area for the DEIS will be the Puyallup River downstream of...

  18. Tiempo para un cambio

    NASA Astrophysics Data System (ADS)

    Woltjer, L.

    1987-06-01

    En la reunion celebrada en diciembre dei ano pasado informe al Consejo de mi deseo de terminar mi contrato como Director General de la ESO una vez que fuera aprobado el proyecto dei VLT, que se espera sucedera hacia fines de este aAo. Cuando fue renovada mi designacion hace tres aAos, el Consejo conocia mi intencion de no completar los cinco aAos dei contrato debido a mi deseo de disponer de mas tiempo para otras actividades. Ahora, una vez terminada la fase preparatoria para el VLT, Y habiendose presentado el proyecto formalmente al Consejo el dia 31 de marzo, y esperando su muy probable aprobacion antes dei termino de este ano, me parece que el 10 de enero de 1988 presenta una excelente fecha para que se produzca un cambio en la administracion de la ESO.

  19. Diffraction-Enhanced Imaging of Musculoskeletal Tissues Using a Conventional X-Ray Tube

    SciTech Connect

    Muehleman, C.; Li, J; Connor, D; Parham, C; Pisano, E; Zhong, Z

    2009-01-01

    DEI based on a conventional x-ray tube allows the visualization of skeletal and soft tissues simultaneously. Although more in-depth testing and optimization of the DEI setup must be carried out, these data demonstrate a proof of principle for further development of the technology for future clinical imaging. In conventional projection radiography, cartilage and other soft tissues do not produce enough radiographic contrast to be distinguishable from each other. Diffraction-enhanced imaging (DEI) uses a monochromatic x-ray beam and a silicon crystal analyzer to produce images in which attenuation contrast is greatly enhanced and x-ray refraction at tissue boundaries can be detected. The aim of this study was to test the efficacy of conventional x-ray tube-based DEI for the detection of soft tissues in experimental samples.

  20. 76 FR 50490 - Draft Comprehensive Conservation Plan and Draft Environmental Impact Statement, Arctic National...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-15

    ... Fish and Wildlife Service Draft Comprehensive Conservation Plan and Draft Environmental Impact... conservation plan (CCP) and draft environmental impact statement (DEIS) for the Arctic National Wildlife Refuge... Refuge System, consistent with sound principles of fish and wildlife management, conservation,...

  1. Evaluation of x-ray diffraction enhanced imaging in the diagnosis of breast cancer.

    PubMed

    Liu, Chenglin; Yan, Xiaohui; Zhang, Xinyi; Yang, Wentao; Peng, Weijun; Shi, Daren; Zhu, Peiping; Huang, Wanxia; Yuan, Qingxi

    2007-01-21

    The significance of the x-ray diffraction enhanced imaging (DEI) technique in the diagnosis of breast cancer and its feasibility in clinical medical imaging are evaluated. Different massive specimens including normal breast tissues, benign breast tumour tissues and malignant breast tumour tissues are imaged with the DEI method. The images are recorded respectively by CCD or x-ray film at different positions of the rocking curve and processed with a pixel-by-pixel algorithm. The characteristics of the DEI images about the normal and diseased tissues are compared. The rocking curves of a double-crystal diffractometer with various tissues are also studied. The differences in DEI images and their rocking curves are evaluated for early diagnosis of breast cancers.

  2. 77 FR 39208 - Notice of Extension of Public Comment Period for Draft Environmental Impact Statement: North Fork...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-02

    ... Protection Agency (EPA) published a notice of availability (NOA) of the DEIS in the Federal Register on May 25, 2012 . The NOA provided for a public comment period ending on July 9, 2012. DATES: Due to...

  3. Sentinel node radioguided biopsy in surgical management of the medullary thyroid carcinoma A case report.

    PubMed

    Boni, Giuseppe; Mazzarri, Sara; Grosso, Mariano; Manca, Giampiero; Biricotti, Marco; Ambrosini, Carlo Enrico; Fregoli, Lorenzo; Puccini, Marco; Caldarelli, Claudio; Spisni, Roberto

    2014-01-21

    Il carcinoma midollare della tiroide è raro. Il suo trattamento è chirurgico e consiste in una tiroidectomia totale associata a dissezione dei linfonodi centrali. L’opportunità della linfoadenectomia dei linfonodi cervicali laterali è argomento controverso. Per ridurre l’estensione della dissezione dei linfonodi laterocervicali ai casi in cui tale procedura sia effettivamente necessaria abbiamo eseguito la tecnica della biopsia del linfonodo sentinella, già praticata in altra patologia tumorale, in un caso di carcinoma midollare, sporadico, diagnosticato con ecografia, determinazione dei livelli di calcitonina serica e citologia dell’agoaspirato. All’ecografia non si evidenziavano linfonodi cervicali centrali o laterali. Abbiamo eseguito mappaggio preoperatorio dei linfonodi sentinella iniettando Tecnezio 99-m nel nodulo tiroideo. La paziente è stata poi sottoposta a tiroidectomia totale e biopsia radioguidata dei linfonodi sentinella. L’esame istologico ha confermato la presenza di un carcinoma midollare della tiroide e di micrometastasi in due linfonodi sentinella situati nel compartimento laterale destro. Dopo la tiroidectomia l’intervento è stato completato con dissezione dei compartimenti centrale e laterala destro. Al followup non sono stati rilevati livelli di calcitonina serica nè basali nè dopo stimolazione con pentagastrina. Si tratta del primo caso, riportato in letteratura, che dimostra l’utilità della biopsia radioguidata del linfonodo sentinella nella stadiazione linfonodale e del trattamento chirurgico del microcarcinoma midollare della tiroide. Tale biopsia può essere utile ad eseguire la dissezione linfonodale laterale solo nei pazienti con provato coinvolgimento dei linfonodi laterali del collo e quindi a ridurre l’entità della dissezione e delle relative complicanze.

  4. Squamous cell carcinoma arising on a forearm free flap 21 years after hemiglossectomy.

    PubMed

    Valentini, Valentino; Cassoni, Andrea; Terenzi, Valentina; Prucher, Gianmarco; Zadeh, Oriana Rajabtork; Bosco, Sandro; Belli, Evaristo

    2016-02-04

    Allo stato attuale i lembi liberi ed i peduncolati rappresentano l’opzione di scelta nella ricostruzione dei difetti del cavo orale derivanti dalla resezione di neoplasie maligne. In questi casi la mucosa viene ricostruita nella maggior parte dei casi dalla porzione cutanea del lembo di modo da garantire il rivestimento epiteliale. In rari casi è stata descritta l’insorgenza di tumori secondari a livello della suddetta porzione cutanea.

  5. BPA/Puget Power Northwest Washington Transmission Project Final Environmental Impact Statement.

    SciTech Connect

    United States. Bonneville Power Administration.

    1995-08-01

    Bonneville Power Administration (BPA) and Puget Sound Power & Light Company (Puget Power) propose to upgrade the existing high-voltage transmission system in the Whatcom and Skagit counties area between the towns of Custer and Sedro Woolley, including some areas within the City of Bellingham, starting in 1995. A Draft Environmental Impact Statement (DEIS) for the project was issued in November 1993, followed by a 45-day public comment period. Public response to the DEIS included the identification of several new transmission route alternatives in the Lake Whatcom area. BPA issued a Supplemental DEIS in April 1995 to provide a second public review-and-comment period. Rebuilding an existing 230-kV line to a double-circuit 230-kV transmission line was identified in the Supplemental DEIS as the Proposed Action. The Supplemental DEIS also examined in detail a North Shore Road alternative which was proposed by some members of the public. Public comments on the EIS were listed and responded to in the Supplemental DEIS. In May 1995, a second set of open houses and public meetings was held to review the Supplemental DEIS. Electromagnetic field (EMF) effects raised as an issue in the DEIS continued to be an issue of public concern in the meetings. The EIS has identified impacts that would generally be classified as low to moderate and localized. Effects on soils and water resources in sensitive areas (e.g., near Lake Whatcom) would be low to moderate; there would be little change in magnetic fields; noise levels would remain at existing levels; and land use and property value impacts would be minimal. Threatened and endangered species would not be adversely affected, and all proposed actions in wetlands would be covered by a Corps of Engineers Nationwide Permit. Visual and socioeconomic would be low to moderate. There would be no effect on cultural resources.

  6. [The importance of sleep deprivation as a mechanism for activating interictal epileptiform paroxysms].

    PubMed

    Navas, Patricia; Rodríguez-Santos, Lucía; Bauzano-Poley, Enrique; Lara, José Pablo; Barbancho, Miguel Ángel

    2016-04-01

    Introduccion. Aunque la privacion de sueño se ha utilizado durante años en electroencefalografia (EEG) como metodo de activacion de descargas epileptiformes intercriticas (DEI) en pacientes con alta sospecha de epilepsia, su sensibilidad y especificidad estan aun en discusion. Pacientes y metodos. Estudio descriptivo y retrospectivo de pacientes pediatricos derivados a neurofisiologia clinica para valoracion de epilepsia. Se han comparado los resultados de los EEG de privacion de sueño (EEG-PS) con los EEG de vigilia (EEG-V) en cada paciente para describir su rendimiento como mecanismo activador de DEI. Resultados. Se han analizado 500 pacientes (830 EEG-PS y 1.018 EEG-V). En los EEG-V se detectaron DEI en el 44%. El EEG-PS aumento en un 35% la capacidad del test para detectar las DEI. En los EEG-PS en los que se alcanzo sueño espontaneo se observaron DEI (no detectadas en el EEG-V) en un 25,1%. En el grupo de epilepsias focales se constato que el EEG-V detecto DEI en el 60,1% frente al 79,12% demostradas con el EEG-PS. En las epilepsias generalizadas esta diferencia fue mas marcada (27,2% y 77,2%, respectivamente). En los pacientes en los que tras un EEG-PS no se detectaron DEI (23,7%) y la sospecha clinica de epilepsia seguia siendo alta, se realizo polisomnografia nocturna y se llego a objetivar actividad epileptiforme intercritica en un 13,6%. Conclusiones. El EEG-PS aumenta la posibilidad de recoger DEI en un 35% con respecto al EEG-V. La privacion de sueño es un metodo activador de paroxismos epileptiformes, independientemente de si hay sueño o no durante la realizacion del EEG, aunque este efecto es mas marcado en los pacientes que alcanzan sueño.

  7. Introduzione al Laboratorio di Fisica

    NASA Astrophysics Data System (ADS)

    Ciullo, Giuseppe

    La Fisica (dal greco τὰ ϕυσικὰ: le cose naturali) si pone l'obiettivo di descrivere e prevedere il comportamento dei fenomeni naturali, nonché degli apparati e degli strumenti, che hanno reso e rendono la nostra vita più comoda ed efficiente. Tale obiettivo viene perseguito mediante un'attenta osservazione dei fenomeni, con una conseguente schematizzazione dell'osservazione, per fornire una conoscenza della realtà oggettiva, affidabile, verificabile e condivisibile.

  8. Adherence and Dosage Contributions to Parenting Program Quality

    PubMed Central

    Gross, Thomas J.; Mason, W. Alex; Parra, Gilbert; Oats, Robert; Ringle, Jay; Haggerty, Kevin P.

    2015-01-01

    Objective The 3 most frequently examined elements of treatment fidelity are adherence, dosage, and quality. The relationships between these fidelity elements are complex, and additional research is needed to provide clarity. Improving clarity may be especially relevant to parenting programs, which tend to include direct explicit instruction (DEI) elements (i.e., instruction, modeling, and practice). The adherence to and dosage of these DEI elements are frequently assumed to improve program quality; however, little information is available to determine if such adherence and dosage affect program quality. This study examines whether adherence to and dosage of DEI elements predict quality ratings for a widely disseminated, manualized parenting program. Method Adherence is defined as the percentage of intervention tasks completed for each DEI element. Dosage is defined as the number of minutes and seconds spent in each intervention DEI element. Treatment fidelity is assessed for 36 of 144 sessions across 10 program facilitators. A hierarchical linear regression analysis examines the contributions of adherence and dosage in the prediction of session quality ratings. Results The analysis indicates that adherence accounts for a significant proportion of the variance (26%), whereas dosage contributes a nonsignificant proportion of variance (11%). Adherence to skill practice was the strongest individual predictor (β = .445, p < .01). Conclusions Findings suggest that ensuring a high degree of adherence can contribute to quality program delivery. However, more exploration is needed to better understand the ways in which adherence and dosage of DEI elements affect program quality. PMID:26726301

  9. Preliminayr Study on Diffraction Enhanced Radiographic Imaging for a Canine Model of Cartilage Damage

    SciTech Connect

    Muehleman,C.; Li, J.; Zhong, Z.

    2006-01-01

    Objective: To demonstrate the ability of a novel radiographic technique, Diffraction Enhanced Radiographic Imaging (DEI), to render high contrast images of canine knee joints for identification of cartilage lesions in situ. Methods: DEI was carried out at the X-15A beamline at Brookhaven National Laboratory on intact canine knee joints with varying levels of cartilage damage. Two independent observers graded the DE images for lesions and these grades were correlated to the gross morphological grade. Results: The correlation of gross visual grades with DEI grades for the 18 canine knee joints as determined by observer 1 (r2=0.8856, P=0.001) and observer 2 (r2=0.8818, P=0.001) was high. The overall weighted ? value for inter-observer agreement was 0.93, thus considered high agreement. Conclusion: The present study is the first study for the efficacy of DEI for cartilage lesions in an animal joint, from very early signs through erosion down to subchondral bone, representing the spectrum of cartilage changes occurring in human osteoarthritis (OA). Here we show that DEI allows the visualization of cartilage lesions in intact canine knee joints with good accuracy. Hence, DEI may be applicable for following joint degeneration in animal models of OA.

  10. X-ray diffraction enhanced imaging as a novel method to visualize low-density scaffolds in soft tissue engineering.

    PubMed

    Zhu, Ning; Chapman, Dean; Cooper, David; Schreyer, David J; Chen, Xiongbiao

    2011-11-01

    Scaffold visualization is challenging yet essential to the success of various tissue engineering applications. The aim of this study was to explore the potential of X-ray diffraction enhanced imaging (DEI) as a novel method for the visualization of low density engineered scaffolds in soft tissue. Imaging of the scaffolds made from poly(L-lactide) (PLLA) and chitosan was conducted using synchrotron radiation-based radiography, in-line phase-contrast imaging (in-line PCI), and DEI techniques as well as laboratory-based radiography. Scaffolds were visualized in air, water, and rat muscle tissue. Compared with the images from X-ray radiography and in-line PCI techniques, DEI images more clearly show the structure of the low density scaffold in air and have enhanced image contrast. DEI was the only technique able to visualize scaffolds embedded in unstained muscle tissue; this method could also define the microstructure of muscle tissue in the boundary areas. At a photon energy of 20 KeV, DEI had the capacity to image PLLA/chitosan scaffolds in soft tissue with a sample thickness of up to 4 cm. The DEI technique can be applied at high X-ray energies, thus facilitating lower in vivo radiation doses to tissues during imaging as compared to conventional radiography.

  11. A study of monochromatic x-ray area beam for application in diffraction enhanced imaging

    NASA Astrophysics Data System (ADS)

    Kim, Chang Hyeuk

    Synchrotron-based Diffraction Enhanced Imaging (DEI) system has shown improved contrast images on low attenuation material. In a previous DEI study great potential to detect earlier stage breast cancer was reported. However, to apply DEI technique at the clinical level, a synchrotron source is not feasible for clinically-approved systems due to the size of the accelerator, and hence a compact x-ray source that can replace synchrotron is desirable. Development of an x-ray source compatible to synchrotron radiation is an essential part for a clinical DEI system. Some important features for the design of an x-ray source, based on synchrotron radiation, are the photon flux and beam collimation. The NCSU research group suggested a wide-beam x-ray source, which consists of concentric circular filaments producing electron flux onto a cylindrically-shaped oxygen-free copper stationary target with a thin layer of Molybdenum for x-ray production. This source design emphasizes large field of view, which can eliminate the line by line scanning process experienced in a DEI experimental setup. In this study, the proof of principle model of a wide beam x-ray source was used to study for control electron trajectory of the concentric filaments design, calculations of the produced x-ray flux, simulation of the DEI imaging, and estimation of the operation time with target's active cooling system. The DEI images from the electron distribution were computationally generated by adopting a monochromator and an analyzer with a computationally generated dual cylindrical object. The image simulation showed that the wide-beam x-ray source based DEI images are highly dependent on the electron distribution at the target. Uniform electron distribution by electron trajectory optimization is carried out through independent powering of the filaments inside the focusing cup. For higher electron beam current the x-ray flux satisfies obtaining a successful DEI image scan, but such high current

  12. Quantification of microarchitectural anisotropy in bone with diffraction enhanced imaging

    NASA Astrophysics Data System (ADS)

    Connor, Dean M.; Mehrotra, Meenal; LaRue, Amanda C.

    2014-03-01

    Purpose: The purpose of this study is to determine if diffraction enhanced imaging (DEI) can quantify anisotropy in bone microarchitecture. Background: Osteoporosis is characterized by low bone mass and microarchitectural deterioration of bone. A noninvasive tool for measuring the degree of anisotropy (DA) in bone microarchitecture will help clinicians better assess fracture risk in osteoporotic patients. DEI detects small angular deflections in an x-ray beam, and is only sensitive to angular changes in one plane. If the beam is refracted by multiple anisotropic microstructures (e.g. osteocyte lacunae and pores) in bone, the angular spreading can be measured with DEI and differences in the amount of spreading for different bone orientations is indicative of the DA in bone microarchitecture. Method: An x-ray-tube based DEI system was used to collect an array of DEI reflectivity profiles measured through bovine cortical bone samples with the bones oriented with the bone axis in the plane perpendicular to the propagation of the x-ray beam. Micro-CT images of the bones were obtained using a Scanco uCT40 ex vivo scanner, and the DA of the pore structure was quantified using BoneJ. Results: The maximum and minimum measured reflectivity profile widths through bone varied by a factor of two; this suggests that the microarchitecture is preferentially aligned with the bone axis in a 2-to-1 ratio. The DA for the cortical pores was 0.6, which agrees with DEI's anisotropy measure. Conclusions: The preliminary findings of this study suggest that DEI is sensitive to anisotropy in bone microarchitecture.

  13. Noise properties and task-based evaluation of diffraction-enhanced imaging

    PubMed Central

    Brankov, Jovan G.; Saiz-Herranz, Alejandro; Wernick, Miles N.

    2014-01-01

    Abstract. Diffraction-enhanced imaging (DEI) is an emerging x-ray imaging method that simultaneously yields x-ray attenuation and refraction images and holds great promise for soft-tissue imaging. The DEI has been mainly studied using synchrotron sources, but efforts have been made to transition the technology to more practical implementations using conventional x-ray sources. The main technical challenge of this transition lies in the relatively lower x-ray flux obtained from conventional sources, leading to photon-limited data contaminated by Poisson noise. Several issues that must be understood in order to design and optimize DEI imaging systems with respect to noise performance are addressed. Specifically, we: (a) develop equations describing the noise properties of DEI images, (b) derive the conditions under which the DEI algorithm is statistically optimal, (c) characterize the imaging performance that can be obtained as measured by task-based metrics, and (d) consider image-processing steps that may be employed to mitigate noise effects. PMID:26158056

  14. Computed tomography of amyloid plaques in a mouse model of Alzheimers disease using diffraction enhanced imaging

    SciTech Connect

    Connor, D.M.; Miller, L.; Benveniste, H.; Dilmanian, A.; Kritzer, M.; Zhong, Z.

    2009-03-19

    Our understanding of early development in Alzheimer's disease (AD) is clouded by the scale at which the disease progresses; amyloid beta (A{beta}) plaques, a hallmark feature of AD, are small ({approx} 50 {micro}m) and low contrast in diagnostic clinical imaging techniques. Diffraction enhanced imaging (DEI), a phase contrast x-ray imaging technique, has greater soft tissue contrast than conventional radiography and generates higher resolution images than magnetic resonance microimaging. Thus, in this proof of principle study, DEI in micro-CT mode was performed on the brains of AD-model mice to determine if DEI can visualize A{beta} plaques. Results revealed small nodules in the cortex and hippocampus of the brain. Histology confirmed that the features seen in the DEI images of the brain were A{beta} plaques. Several anatomical structures, including hippocampal subregions and white matter tracks, were also observed. Thus, DEI has strong promise in early diagnosis of AD, as well as general studies of the mouse brain.

  15. A micro-tomography method based on X-ray diffraction enhanced imaging for the visualization of micro-organs and soft tissues.

    PubMed

    Gao, Xin; Luo, Shunqian; Yin, Hongxia; Liu, Bo; Xu, Maolin; Yuan, Qingxi; Gao, Xiulai; Zhu, Peiping

    2006-01-01

    Diffraction enhanced imaging (DEI) is one of the phase contrast imaging methods using the monochromatic X-ray from synchrotron, which provides information on the out-of-plane angular deviation of X-ray. DEI allows the investigation of micro-structures inside weakly absorbing samples at high spatial resolution without serious radiation exposure. Tomographic techniques can be applied readily to phase contrast images. The combination of DEI and tomography allows for a reconstruction of refractive index gradient distribution inside weakly absorbing samples with micrometer resolution, particularly suited for the 3D observation of micro-organisms and tissues. The existing phase contrast tomography methods based on DEI use phase contrast images as projections, such images contain not only the phase information, but also the absorption information. A novel method (DEI in the tomography mode) was developed to greatly increase the proportion of refraction information in phase contrast images by computing the difference between the two sets of images acquired at different angles of the rocking curve to adopt the projections with a complete set (2pi) for reconstruction. The reconstructed images of cochlea of a guinea pig showed the spatial structures and the micro-features inside the samples. The new method reveals higher spatial resolution compared to the conventional phase contrast tomography methods and is more suitable to the investigation of micro-structures of micro-organisms and tissue materials.

  16. Computed tomography diffraction-enhanced imaging for in situ visualization of tissue scaffolds implanted in cartilage.

    PubMed

    Izadifar, Zohreh; Chapman, Leroy Dean; Chen, Xiongbiao

    2014-02-01

    Long-term in vivo studies on animal models and advances from animal to human studies should rely on noninvasive monitoring methods. Synchrotron radiation (SR)-diffraction enhanced imaging (DEI) has shown great promise as a noninvasive method for visualizing native and/or engineered tissues and bio-microstructures with appreciable details in situ. The objective of this study was to investigate SR-DEI for in situ visualization and characterization of tissue-engineered scaffolds implanted in cartilage. A piglet stifle joint implanted with an engineered scaffold made from poly-ɛ-caprolactone was imaged using SR computed tomography (CT)-DEI at an X-ray energy of 40 keV. For comparison, in situ visualization was also conducted with commonly used SR CT-phase contrast imaging and clinical magnetic resonance imaging techniques. The reconstructed CT-DE images show the implanted scaffold with the structural properties much clearer than those in the CT-PC and MR images. Furthermore, CT-DEI was able to visualize microstructures within the cartilage as well as different soft tissues surrounding the joint. These microstructural details were not recognizable using other imaging techniques. Taken together, the results of this study suggest that CT-DEI can be used for noninvasive visualization and characterization of scaffolds in cartilage, representing an advance in tissue engineering to track the success of tissue scaffolds for cartilage repair.

  17. Surgical strategies for cutaneous neoplasm of the scalp. State of art.

    PubMed

    Vitagliano, Tiziana; Greco, Manfredi; Dessy, Luca Andrea; Atzeni, Matteo; Ciriaco, Antonio Greto; Ribuffo, Diego

    2015-01-01

    La ricostruzione dello scalpo è sempre stato un compito arduo ed una sfida, in particolare dopo una demolizione oncologica, e questo articolo offre una visione globale dello stato dell’arte sulle strategie ricostruttive. A questo scopo abbiamo elaborato un algoritmo sistematico per la ricostruzione dello scalpo basato sulla sede e l’estensione del difetto, la presenza o meno del periostio, il coinvolgimento osseo, la qualità dello scalpo circostante, la presenza o meno dei capelli, la localizzazione della linea del capillifero, le comorbilità del paziente e le differenti procedure comunemente usate in chirurgia plastica. Come risultato il nostro algoritmo consente ai chirurghi plastici di procedere alla ricostruzione dello scalpo dopo i difetti più devastanti, ed il successo della ricostruzione richiede una attenta pianificazione preoperatoria ed un approfondita conoscenza dell’anatomia dello scalpo, la fisiologia dei capelli, la varietà dei tessuti localmente disponibili e le procedure di chirurgia plastica, come pure la conoscenza dei sostituiti sintetici e dei prodotti forniti dall’ingegneria tissutale. La sfida attuale è comunque quella di ottenere risultati cosmetici di eccellenza, di cui sono esempio i cinque casi dell’iconografia.

  18. Decommissioning of eight surplus production reactors at the Hanford Site, Richland, Washington. Addendum (Final Environmental Impact Statement)

    SciTech Connect

    Not Available

    1992-12-01

    The first section of this volume summarizes the content of the draft environmental impact statement (DEIS) and this Addendum, which together constitute the final environmental impact statement (FEIS) prepared on the decommissioning of eight surplus plutonium production reactors at Hanford. The FEIS consists of two volumes. The first volume is the DEIS as written. The second volume (this Addendum) consists of a summary; Chapter 9, which contains comments on the DEIS and provides DOE`s responses to the comments; Appendix F, which provides additional health effects information; Appendix K, which contains costs of decommissioning in 1990 dollars; Appendix L, which contains additional graphite leaching data; Appendix M, which contains a discussion of accident scenarios; Appendix N, which contains errata; and Appendix 0, which contains reproductions of the letters, transcripts, and exhibits that constitute the record for the public comment period.

  19. Understanding refraction contrast using a comparison of absorption and refraction computed tomographic techniques

    NASA Astrophysics Data System (ADS)

    Wiebe, S.; Rhoades, G.; Wei, Z.; Rosenberg, A.; Belev, G.; Chapman, D.

    2013-05-01

    Refraction x-ray contrast is an imaging modality used primarily in a research setting at synchrotron facilities, which have a biomedical imaging research program. The most common method for exploiting refraction contrast is by using a technique called Diffraction Enhanced Imaging (DEI). The DEI apparatus allows the detection of refraction between two materials and produces a unique ''edge enhanced'' contrast appearance, very different from the traditional absorption x-ray imaging used in clinical radiology. In this paper we aim to explain the features of x-ray refraction contrast as a typical clinical radiologist would understand. Then a discussion regarding what needs to be considered in the interpretation of the refraction image takes place. Finally we present a discussion about the limitations of planar refraction imaging and the potential of DEI Computed Tomography. This is an original work that has not been submitted to any other source for publication. The authors have no commercial interests or conflicts of interest to disclose.

  20. Acetylcholine Facilitates a Depolarization-Induced Enhancement of Inhibition in Rat CA1 Pyramidal Neurons.

    PubMed

    Domínguez, Soledad; Fernández de Sevilla, David; Buño, Washington

    2017-01-01

    Cholinergic mechanisms in the hippocampus regulate forms of synaptic plasticity linked with cognition and spatial navigation, but the underlying mechanisms remain largely unknown. Here, in rat hippocampal CA1 pyramidal cells under blockade of ionotropic glutamate receptors, we report that a single acetylcholine pulse and repeated depolarization activated a robust and enduring postsynaptic depolarization-induced enhancement of inhibition (DEI) that masked a presynaptic depolarization-induced suppression of inhibition (DSI). Increased cytosolic Ca2+ and M1-muscarinic receptor activation caused the rise in voltage-sensitive α5βγ2-containing γ-aminobutyric acid type-A receptors that generated DEI. In summary, this muscarinic-mediated activity-dependent plasticity rapidly transfers depolarization effects on inhibition from presynaptic suppression or DSI to postsynaptic enhancement or DEI, a change potentially relevant in behavior.

  1. Diffraction enhanced imaging of controlled defects within bone, including bone-metal gaps.

    PubMed

    Connor, D M; Sayers, D; Sumner, D R; Zhong, Z

    2006-06-21

    Gap regions between a bone and an implant, whether existing upon insertion or developing over time, can lead to implant failure. Currently, planar x-ray imaging and CT are the most commonly used methods to evaluate the gap region. An alternative to these available clinical imaging modalities could help to better evaluate bone resorption. Previous experiments with diffraction enhanced imaging (DEI) have shown significant contrast advantages over monochromatic synchrotron radiation (SR) imaging. DEI and planar SR radiography images of bone samples with drill holes and gap regions of known geometry were acquired at the NSLS beamline X15A (Upton, NY, USA). The images acquired with DEI show measurable contrast-to-noise gains when compared to the images acquired using SR radiography.

  2. Diffraction-Enhanced Computed Tomographic Imaging of Growing Piglet Joints by Using a Synchrotron Light Source

    PubMed Central

    Rhoades, Glendon W; Belev, George S; Chapman, L Dean; Wiebe, Sheldon P; Cooper, David M; Wong, Adelaine TF; Rosenberg, Alan M

    2015-01-01

    The objective of this project was to develop and test a new technology for imaging growing joints by means of diffraction-enhanced imaging (DEI) combined with CT and using a synchrotron radiation source. DEI–CT images of an explanted 4-wk-old piglet stifle joint were acquired by using a 40-keV beam. The series of scanned slices was later ‘stitched’ together, forming a 3D dataset. High-resolution DEI-CT images demonstrated fine detail within all joint structures and tissues. Striking detail of vasculature traversing between bone and cartilage, a characteristic of growing but not mature joints, was demonstrated. This report documents for the first time that DEI combined with CT and a synchrotron radiation source can generate more detailed images of intact, growing joints than can currently available conventional imaging modalities. PMID:26310464

  3. Tectonic uplift mechanism of the Goodenough and Fergusson Island gneiss domes, eastern Papua New Guinea: Constraints from seismic reflection and well data

    NASA Astrophysics Data System (ADS)

    Fitz, Guy; Mann, Paul

    2013-10-01

    The D'Entrecasteaux Island (DEI) gneiss domes are fault-bounded domes with ˜2.5 km of relief exposing ultrahigh-pressure (UHP) and high-pressure (HP) metamorphic gneisses and migmatites exhumed in an Oligocene-Miocene arc-continent collision and subduction zone subject to Late Miocene to Recent continental extension. To study the style of continental extension accompanying exhumation of the DEI gneiss domes, a grid of 1518 km of 2-D multichannel seismic (MCS) reflection data and well data is interpreted from the offshore areas surrounding the DEI, including the Trobriand basin and the Goodenough basin. The offshore study is combined with onshore geologic information to constrain the Oligocene to Recent tectonic evolution of the basins. MCS and well data are consistent with the Trobriand basin forming as a forearc basin caused by southward Miocene subduction at the Trobriand trench. At ˜8 Ma, the margin transitioned to an extensional tectonic environment. Since then, the Trobriand basin has subsided 1-2.5 km with few normal faults deforming the basin fill. South of the DEI, the Goodenough rift basin developed after extension began (˜8 Ma) with the hanging wall of the north-dipping Owen-Stanley normal fault bounding the southern margin of the basin. The lack of evidence of upper crustal extension accompanying subsidence in the Trobriand and Goodenough basins suggests depth-dependent lithospheric extension from 8 to 0 Ma has accompanied uplift of the DEI gneiss domes and supports schematic model of uplift of the DEI domes involving vertical exhumation of buoyant, postorogenic lower crust, far-field extension from slab rollback, and an inverted two-layer crustal density structure.

  4. Constraints on Energy Intake in Fish: The Link between Diet Composition, Energy Metabolism, and Energy Intake in Rainbow Trout

    PubMed Central

    Saravanan, Subramanian; Schrama, Johan W.; Figueiredo-Silva, A. Claudia; Kaushik, Sadasivam J.; Verreth, Johan A. J.; Geurden, Inge

    2012-01-01

    The hypothesis was tested that fish fed to satiation with iso-energetic diets differing in macronutrient composition will have different digestible energy intakes (DEI) but similar total heat production. Four iso-energetic diets (2×2 factorial design) were formulated having a contrast in i) the ratio of protein to energy (P/E): high (HP/E) vs. low (LP/E) and ii) the type of non-protein energy (NPE) source: fat vs. carbohydrate which were iso-energetically exchanged. Triplicate groups (35 fish/tank) of rainbow trout were hand-fed each diet twice daily to satiation for 6 weeks under non-limiting water oxygen conditions. Feed intake (FI), DEI (kJ kg−0.8 d−1) and growth (g kg−0.8 d−1) of trout were affected by the interaction between P/E ratio and NPE source of the diet (P<0.05). Regardless of dietary P/E ratio, the inclusion of carbohydrate compared to fat as main NPE source reduced DEI and growth of trout by ∼20%. The diet-induced differences in FI and DEI show that trout did not compensate for the dietary differences in digestible energy or digestible protein contents. Further, changes in body fat store and plasma glucose did not seem to exert a homeostatic feedback control on DEI. Independent of the diet composition, heat production of trout did not differ (P>0.05). Our data suggest that the control of DEI in trout might be a function of heat production, which in turn might reflect a physiological limit related with oxidative metabolism. PMID:22496852

  5. Development of the drug-exposed infant identification algorithm (DEIIA) and its application to measuring part C early intervention referral and eligibility in Massachusetts, 1998-2005.

    PubMed

    Derrington, Taletha Mae

    2013-11-01

    The objectives of this study were to develop an algorithm using government-collected administrative data to identify prenatally drug-exposed infants (DEI) and determine the percent who were referred to and eligible for Part C Early Intervention (EI) in Massachusetts. Data from the population-based Pregnancy to Early Life Longitudinal (PELL) Data System were used to develop the Drug-Exposed Infant Identification Algorithm (DEIIA). The DEIIA uses positive toxicology screens on the birth certificate and International Classification of Diseases, 9th Edition, Clinical Modification diagnostic codes in hospital records of the mother (prenatal and birth) and infant (birth and postnatal) to identify infants affected by substance abuse/dependence, withdrawal, and/or prenatal exposure to non-medical use of controlled substances. PELL-EI data linkages were used to determine the percent referred, evaluated, and eligible. The DEIIA identified 7,348 drug-exposed infants born in Massachusetts from 1998 to 2005 to resident mothers (1.2 % of all births). Most DEI (82.6 %) were identified from maternal/infant birth hospital records. Sixty-one percent of all DEI were referred to EI; 87.2 % of those referred were evaluated, and 89.4 % of those evaluated were found eligible. EI data contained information on drug exposure for 59.9 % of referred DEI. Only 2.8 % of MA resident births who were referred to EI but not identified by the DEIIA had drug indicators in EI data. DEI referrals to EI are federally mandated, but many are not referred. The DEIIA uses data available in most states and could be used as a public health screening tool to improve access to developmental services for DEI.

  6. Integration of offshore seismic data, exploration wells, and onland outcrops as constraints on the tectonics and uplift age of metamorphic core complexes, eastern Papua New Guinea

    NASA Astrophysics Data System (ADS)

    Fitz, G. G.; Mann, P.; Campos Aguiniga, H.

    2009-12-01

    High-grade metamorphic domes of the D’Entrecasteaux Islands (DEI) of eastern Papua New Guinea are located within continental crust at the tip of the westward propagating Woodlark spreading ridge. Multi-channel seismic data collected by the RV Maurice Ewing in 1992 was integrated with seismic data from 1974 and two wells drilled by the oil industry in 1973 to understand pattern and age of faults and clastic wedges in offshore basins surrounding the 2-2.5-km high DEI. The WNW-trending line of the DEI demarcates two areas of contrasting deformational and depositional histories. In the area of the Kiribisi and Trobriand basins north of the DEI, normal faults occupy a WNW-striking basin that began to rift in the early Miocene and continued to rift sporadically until the early Pliocene when all normal faults were buried by ~650 m of undeformed Plio-Pleistocene sediments. We infer that these basins formed as sub-basins within a larger forearc basin bounded to the north by the forearc high of the Trobriand Islands and to the south by the DEI. Uplift of the forearc high and inversion of normal faults near the high during the Pleistocene and suggests the possibility of present-day, southward subduction along the Trobriand trench. To the south of the DEI in the Goodenough basin, the Pleistocene section is thicker and deformed by active, WNW-striking normal faults with seafloor scarps and high-angle dips. Wedging of the Pleistocene clastic fill in a half-graben geometry along the Owen-Stanley fault in the Southern part of the Goodenough basin along the southern coastline of the bay indicates that most normal motion has now shifted to this fault system. The shift in extension from north of the DEI to the Owen-Stanley fault zone in post-Pliocene time likely signals the arrival of the propagating rift tip of the Woodlark basin. The presence of conglomerate with high-grade metamorphic clasts in the Pliocene section north of the DEI supports the idea that the uplift and erosion

  7. Paraho environmental data. Part I. Process characterization. Par II. Air quality. Part III. Water quality

    SciTech Connect

    Heistand, R.N.; Atwood, R.A.; Richardson, K.L.

    1980-06-01

    From 1973 to 1978, Development Engineering, Inc. (DEI), a subsidiary of Paraho Development Corporation, demostrated the Paraho technology for surface oil shale retorting at Anvil Points, Colorado. A considerable amount of environmentally-related research was also conducted. This body of data represents the most comprehensive environmental data base relating to surface retorting that is currently available. In order to make this information available, the DOE Office of Environment has undertaken to compile, assemble, and publish this environmental data. The compilation has been prepared by DEI. This report includes the process characterization, air quality, and water quality categories.

  8. Correlation Function and Generalized Master Equation of Arbitrary Age

    DTIC Science & Technology

    2007-11-02

    P.O. Box 311427, Denton, Texas 76203-1427, USA 3Dipartimento di Fisica dell’Università di Pisa and INFM, Via Buonarroti 2, 56127 Pisa, Italy 4Istituto...dei Processi Chimico Fisici del CNR Area della Ricerca di Pisa, Via G. Moruzzi 1, 56124 Pisa, Italy 5Dipartimento di Fisica and Istituto dei Sistemi...represents the probability of finding the walker at time t in the ith site. states. K is a transition matrix between the sites and Fstd is the memory kernel

  9. [Phenotypes of bone and adipose tissue metabolism. A systematic review of their relationship].

    PubMed

    Nava-González, Edna J; Gallegos-Cabriales, Esther C; Bastarrachea, Raúl A

    2014-01-01

    INTRODUCCIÓN: existe una regulación central de la remodelación ósea en el hipotálamo, vía que al parecer también regula el metabolismo del tejido adiposo. El objetivo de la revisión que se presenta fue explorar la evidencia bibliográfica sobre las relaciones entre la densidad ósea mineral y los fenotipos de la composición corporal, leptina, tejido adiposo y del eje insulina-glucosa. MÉTODOS: se efectuó una búsqueda sistemática en bases de datos electrónicas, para examinar los documentos que abordan discusiones sobre la vinculación del metabolismo óseo mineral y la biología integrativa del tejido adiposo, publicados entre enero de 2005 y noviembre de 2011.

  10. [Neuronal communication and synaptic metabolism in childhood epilepsy].

    PubMed

    García-Cazorla, Àngels; Cortès-Saladelafont, Elisenda; Duarte, Sofia

    2015-03-01

    Introduccion. Los conocimientos que la neurociencia basica y el neurometabolismo estan aportando en epilepsia pediatrica, y en concreto en mecanismos de comunicacion sinaptica, crecen rapidamente. Existe, no obstante, una desconexion entre estos avances y una vision que los integre de manera global y en la practica clinica y terapeutica. Objetivos. Ofrecer una vision integradora de los diferentes mecanismos moleculares y metabolicos que se conocen y postulan en epilepsia pediatrica, y sugerir conceptos como el de 'metabolismo sinaptico' y 'fenotipos sinapticos' como herramientas utiles para desarrollar este enfoque. Desarrollo. Se revisan los estudios mas destacados que intentan explicar las caracteristicas esenciales de la comunicacion sinaptica en el cerebro en desarrollo, a traves de diferentes moleculas, basicamente proteinas sinapticas, canales ionicos (cotransportadores de cloro, sodio y potasio), la compartimentalizacion pre y postsinaptica, y los principales actores metabolicos (neurotransmisores, metabolismo energetico, factores de crecimiento y lipidos). A partir de esta combinacion de mecanismos biologicos se sugieren ejemplos de 'fenotipos sinapticos' en dos casos concretos de epilepsia genetica (SCN1A) y metabolica (epilepsia con respuesta a la piridoxina). Conclusiones. Una perspectiva holistica, entendiendo la diversidad de elementos relacionados y que suceden en determinados momentos del neurodesarrollo, puede ayudar a delinear fenotipos, vias de metabolismo sinaptico y conectividad cerebral, que faciliten no solo la comprension de la fisiopatologia, sino nuevas aproximaciones terapeuticas en epilepsia pediatrica.

  11. [Pharmacogenetics and antiepileptic drug metabolism: implication of genetic variants in cytochromes P450].

    PubMed

    Saldaña-Cruz, Ana Miriam; Sánchez-Corona, José; Márquez de Santiago, Daniel Alejandro; García-Zapién, Alejandra Guadalupe; Flores-Martínez, Silvia Esperanza

    2013-05-01

    Introduccion. Los farmacos antiepilepticos (FAE) son la base para el control de las crisis en pacientes con epilepsia; sin embargo, se conoce que el 20-30% de los pacientes son farmacorresistentes. Son diversos los factores que contribuyen a la variabilidad de la respuesta a los FAE, y esta variabilidad puede atribuirse, al menos en parte, a la presencia de polimorfismos (variaciones de la secuencia) en genes que codifican para enzimas involucradas en el metabolismo de los FAE. Objetivo. Describir las variaciones de la secuencia en genes que codifican para proteinas implicadas en el metabolismo de algunos de los principales FAE, con enfasis en las enzimas citocromo P450 (CYP450). Desarrollo. Existen algunos polimorfismos en genes que codifican para proteinas involucradas en el metabolismo de farmacos, particularmente enzimas de la superfamilia CYP450, que se consideran ya de utilidad clinica en el manejo terapeutico. La presencia de estas variantes geneticas contribuye a la variabilidad de la actividad de enzimas metabolizadoras, lo que, a su vez, influye en la pobre o inadecuada respuesta terapeutica, e incluso en la aparicion de efectos adversos. Conclusiones. La identificacion de la variabilidad interindividual en la respuesta a los diversos FAE puede permitir la individualizacion del tratamiento con la intencion de maximizar su eficacia y minimizar el riesgo, independientemente de que la variabilidad clinica y los efectos adversos se presenten en una minoria de pacientes.

  12. Foreword to "The Secret of Childhood."

    ERIC Educational Resources Information Center

    Stephenson, Margaret E.

    2000-01-01

    Discusses the basic discoveries of Montessori's Casa dei Bambini. Considers principles of Montessori's organizing theory: the absorbent mind, the unfolding nature of life, the spiritual embryo, self-construction, acquisition of culture, creativity of life, repetition of exercise, freedom within limits, children's discovery of knowledge, the secret…

  13. 78 FR 54669 - Draft Environmental Impact Statement for the Proposed RES Americas Moapa Solar Energy Center...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-05

    ... Vegas Review Journal and the Moapa Valley Progress and on the following Web site: www.MoapaSolarEnergy... of a solar energy ground lease and agreements entered into by the Tribe with Moapa Solar LLC... caption ``DEIS Comments, Proposed Moapa Solar Energy Center'' on the first page of your written...

  14. [Conception and embryonic development between poetry and medical science: Dracontius].

    PubMed

    Mazzini, Innocenzo

    2010-01-01

    The article examines on the ancient theme of conception and development of embryo such as presented in the narration of Christus' conception in the De laudibus dei by Dracontius. Dracontius' description is not the only one in ancient Christian poetry, but it is surely the most ancient and the richest in medical details.

  15. 78 FR 19212 - Notice of Availability of a Supplemental Draft Environmental Impact Statement for Effects of Oil...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-29

    ... Draft Environmental Impact Statement for Effects of Oil and Gas Activities in the Arctic Ocean AGENCY... Statement (Supplemental DEIS) for the Effects of Oil and Gas Activities in the Arctic Ocean.'' Publication... authorizing the take of marine mammals incidental to oil and gas exploration activities in the Arctic...

  16. 78 FR 39315 - Notice of Availability of the Draft Environmental Impact Statement and Notice of Public Workshops...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-01

    ... improve operational flexibility of the Sacramento-San Joaquin Delta watershed system by modifying the... Joaquin Delta. DATES: Submit written comments on the DEIS on or before September 30, 2013. Three public...-Delta Authorization Act. In addition, enlargement of Shasta Dam was identified in the...

  17. 77 FR 60679 - Takes of Marine Mammals Incidental to Specified Activities; U.S. Navy Training and Testing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-04

    ... Marine Mammal Protection Act (MMPA), NMFS announces our receipt of the Navy's request for the development...). NMFS is a cooperating agency in the development of the Navy's DEIS for AFTT. The dates and times of the...; anti- submarine warfare; mine warfare; naval special warfare; Naval Air Systems Command...

  18. 77 FR 62257 - Draft Environmental Impact Statement for the Herring River Restoration Project, Cape Cod National...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-12

    ...-0081-422] Draft Environmental Impact Statement for the Herring River Restoration Project, Cape Cod... Statement (DEIS) for the Herring River Restoration Project in Cape Cod National Seashore, Massachusetts. The... scheduled, the meeting date will be announced via the Cape Cod National Seashore Web site (...

  19. 77 FR 23743 - Draft Environmental Impact Statement and Proposed Amendment of the Washington Department of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-20

    ... murrelet habitat assessment results, and described adaptive management concepts. The Report provided... draft HCP for forest management activities covering 1.6 million acres of forested State trust lands... announced in the Federal Register on April 5, 1996 (61 FR 15297). The DEIS analyzed reasonable...

  20. Algunos Resumenes

    NASA Astrophysics Data System (ADS)

    1982-09-01

    La agenda comienza con un resumen de parte dei Director General: estado de los proyectos de telescopios mas importantes, instrumentaci6n futura y otros asuntos. Luego el Director en Chile y el Jefe de TRS describen las condiciones presentes en que se encuentran los instrumentos, los problemas que han surgido y aquellos que se esperan. Luego estos puntos son disculidos por el Comite.

  1. Meet the Maximally Exposed Member of the Public: The Service Station Attendant for Spent Nuclear Fuel Going to Yucca Mountain

    SciTech Connect

    Collins, H. E.; Gathers, R.; Halstead, R. J.

    2002-02-28

    According to the 1999 Draft Environmental Impact Statement (DEIS) for the proposed Yucca Mountain repository site, members of the public along transportation routes by which spent nuclear fuel (SNF) and high-level radioactive waste (HLW) is shipped will receive annual radiation doses less than 100 mrem/yr, the international (ICRP) and national (Department of Energy, Nuclear Regulatory Commission) radiation limit for members of the public. For the ''Mostly Truck'' national transportation scenario, the DEIS specifically concludes that the maximally exposed member of the public, a service station attendant along the primary shipping route will receive no more than 100 mrem/yr, or 2.4 rem over 24 years. Based on the assumptions in the DEIS scenarios, however, it is highly likely that service station attendants along shipping routes will be called upon to fuel and service the rigs carrying SNF and HLW to Yucca Mountain. After reevaluating the DEIS, and making realistic alternative assumptions where necessary, the authors conclude that these attendants are likely to receive substantially more than 100 mrem/yr external dose, and perhaps several times that dose (up to 500 mrem/yr), unless mitigating measures are adopted. This is particularly true in Western states where refueling opportunities are limited, and the distances between fuel sources in rural areas may be up to 100 miles.

  2. 75 FR 17132 - Intent To Prepare a Draft Environmental Impact Statement for Hurricane and Storm Damage Reduction...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-05

    ... Hurricane and Storm Damage Reduction for South Ponte Vedra Beach, Vilano Beach, and Summer Haven Beach... Draft Environmental Impact Statement (DEIS) for evaluation of the feasibility of providing hurricane and... in the interest of beach erosion control, hurricane protection and related purposes, provided...

  3. 77 FR 23669 - Public Hearing and Notice of Availability for the Draft Environmental Impact Statement for the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-20

    ...., Grand Magnolia Ballroom, 3604 Magnolia Street, Pascagoula, Mississippi. Written comments on the DEIS... Magnolia Ballroom at 3604 Magnolia Street, Pascagoula, Mississippi. The public hearing will be held to... held from 6 p.m. until 7 p.m. in the Grand Magnolia Ballroom to allow the public the opportunity...

  4. The LIS Corpus Project: A Discussion of Sociolinguistic Variation in the Lexicon

    ERIC Educational Resources Information Center

    Geraci, Carlo; Battaglia, Katia; Cardinaletti, Anna; Cecchetto, Carlo; Donati, Caterina; Giudice, Serena; Mereghetti, Emiliano

    2011-01-01

    Following a well-established tradition going back to the 1980s (cf. Volterra 1987/2004), the authors use the name Lingua dei Segni Italiana (Italian Sign Language [LIS]) for the language used by Italian deaf people (and by Swiss deaf people living in the Ticino canton). LIS is becoming more and more visible, and its status as a minority language…

  5. 75 FR 62417 - Draft Environmental Impact Statement for the Proposed Manzanita Band of Kumeyaay Indians Fee-to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-08

    ... justice, growth inducing effects, indirect effects, cumulative effects, and mitigation measures... plant). In addition, there will be a 46,000-square-foot banquet/meeting hall and 200-room hotel. The... Action. Environmental issues addressed in the DEIS include land resources, water resources, air...

  6. 78 FR 37568 - Draft Environmental Impact Statement for Proposed Strategies To Benefit Native Species by...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-21

    ... addressed in the DEIS include: (1) Biological resources (lake trout, bull trout, westslope cutthroat trout... Species by Reducing the Abundance of Lake Trout in Flathead Lake, Montana AGENCY: Bureau of Indian Affairs... Benefit Native Species by Reducing the Abundance of Lake Trout in Flathead Lake, Montana. This notice...

  7. A Modular, Reconfigurable Surveillance UAV Architecture

    DTIC Science & Technology

    2007-11-02

    Una Società Galileo Avionica A Modular, Reconfigurable Surveillance UAV Architecture METEOR, Finmeccanica Group Zona Industriale di Soleschiano Via...ES) METEOR, Finmeccanica Group Zona Industriale di Soleschiano Via Mario Stoppani 21 34077 Ronchi dei Legionari (GO) ITALY 8. PERFORMING

  8. Go Forth and Multiply: How the Chaplain’s Actions can Have Strategic Impact in the Current Operational Environment

    DTIC Science & Technology

    2009-10-23

    motivated by the foundational theological tenet of Imago Dei , the idea that human beings are created in the image of God and therefore have...U.S. Circuit Court of Appeals, vol. 755, 1985. Koppelman, Alex . “‟These people should be court-martialed‟: Former Air Force officer, Mikey

  9. Assistive Technology for Every Child

    ERIC Educational Resources Information Center

    Boyd, Barbara Foulks

    2008-01-01

    The Montessori philosophy advocates that the classroom be a reflection of the home, the community, and the world. Now, a century after Maria Montessori founded her Casa dei Bambini, the world is becoming a high-technology society, with computers a part of everyday American lives. Computers are almost a household necessity, and basic…

  10. 78 FR 52764 - Extension of Public Comment Period Hydrogen Energy California's Integrated Gasification Combined...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-26

    ... Project Preliminary Staff Assessment and Draft Environmental Impact Statement AGENCY: U.S. Department of... Gasification Combined Cycle Project Preliminary Staff Assessment/Draft Environmental Impact Statement (PSA/DEIS... to California Energy Commission (CEC) or DOE concerning the Hydrogen Energy California Project...

  11. 75 FR 34189 - Self-Regulatory Organizations; Notice of Filing of Proposed Rule Change by EDGA Exchange, Inc...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-16

    ...-owned subsidiary of DE Holdings. \\5\\ EDGA Bylaws, Article I., Section kk. \\6\\ See 15 U.S.C. 78s. See... EDGA Bylaws, Article I., Section kk. \\18\\ See DEI Certificate, Article VIII., Section 3. The Exchange... responsibilities under the Act. \\19\\ See EDGA Bylaws, Article I., Section kk. \\20\\ See 15 U.S.C. 78s. See...

  12. 75 FR 34196 - Self-Regulatory Organizations; Notice of Filing of Proposed Rule Change by EDGX Exchange, Inc...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-16

    ...-owned subsidiary of DE Holdings. \\5\\ EDGA Bylaws, Article I., Section kk. \\6\\ See 15 U.S.C. 78s. See... EDGX Bylaws, Article I., Section kk. \\18\\ See DEI Certificate, Article VIII, Section 3. The Exchange... responsibilities under the Act. \\19\\ See EDGX Bylaws, Article I., Section kk. \\20\\ See 15 U.S.C. 78s. See...

  13. 75 FR 43584 - Self-Regulatory Organizations; EDGX Exchange, Inc; Order Approving a Proposed Rule Change...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-26

    ..., Article I(kk). Any changes to the Exchange Bylaws, including a change to the provision that identifies DE... fulfill their regulatory and oversight obligations under the Act. \\12\\ See Exchange Bylaws, Article I(kk... Commission.\\29\\ \\26\\ See Exchange Bylaws, Article I(kk). \\27\\ See 15 U.S.C. 78s. \\28\\ See DEI...

  14. 75 FR 43582 - Self-Regulatory Organizations; EDGA Exchange, Inc.; Order Approving a Proposed Rule Change...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-26

    ..., Article I(kk). Any changes to the Exchange Bylaws, including a change to the provision that identifies DE... fulfill their regulatory and oversight obligations under the Act. \\12\\ See Exchange Bylaws, Article I(kk... Commission.\\29\\ \\26\\ See Exchange Bylaws, Article I(kk). \\27\\ See 15 U.S.C. 78s. \\28\\ See DEI...

  15. Final environmental impact statement, Washington Water Power/B.C. Hydro Transmission Interconnection Project

    SciTech Connect

    Not Available

    1992-10-01

    Washington Water Power (WWP) proposes to construct and operate an electric transmission line that would connect with the electrical system of the British Columbia Hydro and Power Authority (B.C. Hydro). The project would be composed of a double-circuit, 230-kilovolt (kV) transmission line from WWP`s existing Beacon Substation located northeast of Spokane, Washington to the international border located northwest of Metaline Falls, Washington. The original Presidential permit application and associated proposed route presented in the draft environmental impact statement (DEIS) have been modified to terminate at the Beacon Substation, instead of WWP`s initially proposed termination point at the planned Marshall Substation located southwest of Spokane. A supplemental draft EIS was prepared and submitted for review to not only examine the new proposed 5.6 miles of route, but to also compare the new Proposed Route to the other alternatives previously analyzed in the DEIS. This final EIS (FEIS) assesses the environmental effects of the proposed transmission line through construction, operation, maintenance, and abandonment activities and addresses the impacts associated with the Proposed Action, Eastern Alternative, Western Alternative, Northern Crossover Alternative, Southern Crossover Alternative, and No Action Alternative. The FEIS also contains the comments received and the responses to these comments submitted on the DEIS and Supplemental DEIS.

  16. 47 CFR 1.1305 - Actions which normally will have a significant impact upon the environment, for which...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... impact upon the environment, for which Environmental Impact Statements must be prepared. 1.1305 Section 1... which normally will have a significant impact upon the environment, for which Environmental Impact... the human environment requires the preparation of a Draft Environmental Impact Statement (DEIS)...

  17. 47 CFR 1.1305 - Actions which normally will have a significant impact upon the environment, for which...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... impact upon the environment, for which Environmental Impact Statements must be prepared. 1.1305 Section 1... which normally will have a significant impact upon the environment, for which Environmental Impact... the human environment requires the preparation of a Draft Environmental Impact Statement (DEIS)...

  18. 47 CFR 1.1305 - Actions which normally will have a significant impact upon the environment, for which...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... impact upon the environment, for which Environmental Impact Statements must be prepared. 1.1305 Section 1... which normally will have a significant impact upon the environment, for which Environmental Impact... the human environment requires the preparation of a Draft Environmental Impact Statement (DEIS)...

  19. Algunos Resumenes

    NASA Astrophysics Data System (ADS)

    1980-03-01

    En una sesion especial celebrada en Ginebra el dia 26 de marzo el Consejo de la ESO aeepto por unanimidad a Italia y Suiza eomo nuevos estados miembros de la organizaeion. Una vez que los proeedimientos necesarios para la ratifieaeion por las Camaras de ambos pafses hayan sido eoneluldos eon exito, podrfan ellos ser asoeiados efectivamente a prineipios dei ario 1981.

  20. 77 FR 42487 - Intent To Prepare a Draft Environmental Impact Statement To Reduce Avian Predation on Juvenile...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-19

    ... Avian Predation on Juvenile Salmonids Through Management of Double-Crested Cormorants in the Columbia... to prepare a Draft Environmental Impact Statement (DEIS) to reduce avian predation on juvenile... the Endangered Species Act (ESA). Managing cormorants to reduce predation on salmonids...

  1. Qualitative evaluation of titanium implant integration into bone by diffraction enhanced imaging

    NASA Astrophysics Data System (ADS)

    Wagner, A.; Sachse, A.; Keller, M.; Aurich, M.; Wetzel, W.-D.; Hortschansky, P.; Schmuck, K.; Lohmann, M.; Reime, B.; Metge, J.; Arfelli, F.; Menk, R.; Rigon, L.; Muehleman, C.; Bravin, A.; Coan, P.; Mollenhauer, J.

    2006-03-01

    Diffraction enhanced imaging (DEI) uses refraction of x-rays at edges, which allows pronounced visualization of material borders and rejects scattering which often obscures edges and blurs images. Here, the first evidence is presented that, using DEI, a destruction-free evaluation of the quality of integration of metal implants into bone is possible. Experiments were performed in rabbits and sheep with model implants to investigate the option for DEI as a tool in implant research. The results obtained from DEI were compared to conventional histology obtained from the specimens. DE images allow the identification of the quality of ingrowth of bone into the hydroxyapatite layer of the implant. Incomplete integration of the implant with a remaining gap of less than 0.3 mm caused the presence of a highly refractive edge at the implant/bone border. In contrast, implants with bone fully grown onto the surface did not display a refractive signal. Therefore, the refractive signal could be utilized to diagnose implant healing and/or loosening.

  2. Qualitative evaluation of titanium implant integration into bone by diffraction enhanced imaging.

    PubMed

    Wagner, A; Sachse, A; Keller, M; Aurich, M; Wetzel, W-D; Hortschansky, P; Schmuck, K; Lohmann, M; Reime, B; Metge, J; Arfelli, F; Menk, R; Rigon, L; Muehleman, C; Bravin, A; Coan, P; Mollenhauer, J

    2006-03-07

    Diffraction enhanced imaging (DEI) uses refraction of x-rays at edges, which allows pronounced visualization of material borders and rejects scattering which often obscures edges and blurs images. Here, the first evidence is presented that, using DEI, a destruction-free evaluation of the quality of integration of metal implants into bone is possible. Experiments were performed in rabbits and sheep with model implants to investigate the option for DEI as a tool in implant research. The results obtained from DEI were compared to conventional histology obtained from the specimens. DE images allow the identification of the quality of ingrowth of bone into the hydroxyapatite layer of the implant. Incomplete integration of the implant with a remaining gap of less than 0.3 mm caused the presence of a highly refractive edge at the implant/bone border. In contrast, implants with bone fully grown onto the surface did not display a refractive signal. Therefore, the refractive signal could be utilized to diagnose implant healing and/or loosening.

  3. Seeing the Wood from the Trees: A Critical Policy Analysis of Intersections between Social Class Inequality and Education in Twenty-First Century Ireland

    ERIC Educational Resources Information Center

    Cahill, Kevin

    2015-01-01

    This paper is a critical policy analysis of intersections between social class inequality and education policy in Ireland. The focus is upon contemporary policy and legislation such as The Irish Constitution and equality legislation; social inclusion policies such as the DEIS scheme; literacy and numeracy policy documents; as well as current…

  4. Effects of temperature acclimation on body mass and energy budget in the Chinese bulbul Pycnonotus sinensis

    PubMed Central

    WU, Yu-Nan; Lin, Lin; XIAO, Yu-Chao; Zhou, Li-Meng; WU, Meng-Si; Zhang, Hui-Ying; LIU, Jin-Song

    2014-01-01

    Chinese bulbuls (Pycnonotus sinensis) are small passerine birds that inhabit areas of central, southern and eastern China. Previous observations suggest that free-living individuals of this species may change their food intake in response to seasonal changes in ambient temperature. In the present study, we randomly assigned Chinese bulbuls to either a 30 ℃ or 10 ℃ group, and measured their body mass (BM), body temperature, gross energy intake (GEI), digestible energy intake (DEI), and the length and mass of their digestive tracts over 28 days of acclimation at these temperatures. As predicted, birds in the 30 ℃ group had lower body mass, GEI and DEI relative to those in the 10 ℃ group. The length and mass of the digestive tract was also lower in the 30 ℃ group and trends in these parameters were positively correlated with BM, GEI and DEI. These results suggest that Chinese bulbuls reduced their absolute energy demands at relatively high temperatures by decreasing their body mass, GEI and DEI, and digestive tract size. PMID:24470452

  5. 46 CFR 504.7 - Environmental impact statements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 9 2010-10-01 2010-10-01 false Environmental impact statements. 504.7 Section 504.7... POLICY ANALYSIS § 504.7 Environmental impact statements. (a) General. (1) An environmental impact... environmental impact statements. (1) A draft environmental impact statement (DEIS) will initially be prepared...

  6. 24 CFR 58.60 - Preparation and filing of environmental impact statements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... environmental impact statements. 58.60 Section 58.60 Housing and Urban Development Office of the Secretary... Environmental Impact Statements § 58.60 Preparation and filing of environmental impact statements. (a) The responsible entity must prepare the draft environmental impact statement (DEIS) and the final...

  7. 77 FR 38779 - Notice of Availability of Draft Environmental Impact Statement for the Proposed Mather Specific...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-29

    ... Department of the Army; Corps of Engineers Notice of Availability of Draft Environmental Impact Statement for...-2002-561 AGENCY: Department of the Army, U.S. Army Corps of Engineers, DOD. ACTION: Notice of... Engineers (USACE), Sacramento District has prepared a Draft Environmental Impact Statement (DEIS) to...

  8. 78 FR 64002 - South Farallon Islands Invasive House Mouse Eradication Project; Farallon National Wildlife...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-25

    ... Fish and Wildlife Service South Farallon Islands Invasive House Mouse Eradication Project; Farallon... Environmental Impact Statement (revised DEIS) for the South Farallon Islands Invasive House Mouse Eradication... invasive house mice from the South Farallon Islands, part of the Farallon National Wildlife Refuge off...

  9. 76 FR 48879 - Draft Environmental Impact Statement for Alabama Beach Mouse General Conservation Plan for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-09

    ... Fish and Wildlife Service Draft Environmental Impact Statement for Alabama Beach Mouse General... endangered Alabama beach mouse (Peromyscus polionotus ammobates) in Baldwin County, Alabama. The GCP analyzes... availability of the proposed GCP and the dEIS. These documents analyze the take of the Alabama beach...

  10. A novel crystal-analyzer phase retrieval algorithm and its noise property.

    PubMed

    Bao, Yuan; Wang, Yan; Li, Panyun; Wu, Zhao; Shao, Qigang; Gao, Kun; Wang, Zhili; Ju, Zaiqiang; Zhang, Kai; Yuan, Qingxi; Huang, Wanxia; Zhu, Peiping; Wu, Ziyu

    2015-05-01

    A description of the rocking curve in diffraction enhanced imaging (DEI) is presented in terms of the angular signal response function and a simple multi-information retrieval algorithm based on the cosine function fitting. A comprehensive analysis of noise properties of DEI is also given considering the noise transfer characteristic of the X-ray source. The validation has been performed with synchrotron radiation experimental data and Monte Carlo simulations based on the Geant4 toolkit combined with the refractive process of X-rays, which show good agreement with each other. Moreover, results indicate that the signal-to-noise ratios of the refraction and scattering images are about one order of magnitude better than that of the absorption image at the edges of low-Z samples. The noise penalty is drastically reduced with the increasing photon flux and visibility. Finally, this work demonstrates that the analytical method can build an interesting connection between DEI and GDPCI (grating-based differential phase contrast imaging) and is widely suitable for a variety of measurement noise in the angular signal response imaging prototype. The analysis significantly contributes to the understanding of noise characteristics of DEI images and may allow improvements to the signal-to-noise ratio in biomedical and material science imaging.

  11. Clean Up, Rehabilitation, Resettlement of Enewetak Atoll -Marshall Islands. Volume III.

    DTIC Science & Technology

    The documentation is a summary of the Draft Environmental Impact Statement (DEIS) for a proposed project to clean up the Atoll of Enewetak and...resettle the Enewetak people on the Atoll . The summary has been prepared specifically for translation into the language of the Enewetak people.

  12. Ahead of the Curve: State Success in the Developmental Education Initiative

    ERIC Educational Resources Information Center

    Altstadt, David

    2012-01-01

    Building on their work through Achieving the Dream, six states and 15 community colleges joined the Developmental Education Initiative (DEI) in 2009 to take on one of higher education's most daunting challenges: improving the success of students who enter community college academically underprepared. The states and Jobs for the Future, which…

  13. 77 FR 12323 - Draft Environmental Impact Statement for the General Management Plan, Buck Island Reef National...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-29

    ... National Park Service Draft Environmental Impact Statement for the General Management Plan, Buck Island Reef National Monument, Virgin Islands AGENCY: National Park Service, Interior. ACTION: Notice of Availability of a Draft Environmental Impact Statement for the General Management Plan (DEIS/GMP), Buck...

  14. 49 CFR 520.24 - Internal processing of draft environmental impact statements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 6 2012-10-01 2012-10-01 false Internal processing of draft environmental impact... ENVIRONMENTAL IMPACTS Procedures § 520.24 Internal processing of draft environmental impact statements. Before... that a potentially significant environmental effect exists; (b) Attach the DEIS; (c) Identify...

  15. 46 CFR 504.7 - Environmental impact statements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 9 2012-10-01 2012-10-01 false Environmental impact statements. 504.7 Section 504.7... POLICY ANALYSIS § 504.7 Environmental impact statements. (a) General. (1) An environmental impact... environmental impact statements. (1) A draft environmental impact statement (DEIS) will initially be prepared...

  16. 49 CFR 520.24 - Internal processing of draft environmental impact statements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 6 2013-10-01 2013-10-01 false Internal processing of draft environmental impact... ENVIRONMENTAL IMPACTS Procedures § 520.24 Internal processing of draft environmental impact statements. Before... that a potentially significant environmental effect exists; (b) Attach the DEIS; (c) Identify...

  17. 49 CFR 520.24 - Internal processing of draft environmental impact statements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 6 2014-10-01 2014-10-01 false Internal processing of draft environmental impact... ENVIRONMENTAL IMPACTS Procedures § 520.24 Internal processing of draft environmental impact statements. Before... that a potentially significant environmental effect exists; (b) Attach the DEIS; (c) Identify...

  18. 24 CFR 58.60 - Preparation and filing of environmental impact statements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... environmental impact statements. 58.60 Section 58.60 Housing and Urban Development Office of the Secretary... Environmental Impact Statements § 58.60 Preparation and filing of environmental impact statements. (a) The responsible entity must prepare the draft environmental impact statement (DEIS) and the final...

  19. 24 CFR 58.60 - Preparation and filing of environmental impact statements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... environmental impact statements. 58.60 Section 58.60 Housing and Urban Development Office of the Secretary... Environmental Impact Statements § 58.60 Preparation and filing of environmental impact statements. (a) The responsible entity must prepare the draft environmental impact statement (DEIS) and the final...

  20. 24 CFR 58.60 - Preparation and filing of environmental impact statements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... environmental impact statements. 58.60 Section 58.60 Housing and Urban Development Office of the Secretary... Environmental Impact Statements § 58.60 Preparation and filing of environmental impact statements. (a) The responsible entity must prepare the draft environmental impact statement (DEIS) and the final...

  1. 24 CFR 58.60 - Preparation and filing of environmental impact statements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... environmental impact statements. 58.60 Section 58.60 Housing and Urban Development Office of the Secretary... Environmental Impact Statements § 58.60 Preparation and filing of environmental impact statements. (a) The responsible entity must prepare the draft environmental impact statement (DEIS) and the final...

  2. 46 CFR 504.7 - Environmental impact statements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 9 2013-10-01 2013-10-01 false Environmental impact statements. 504.7 Section 504.7... POLICY ANALYSIS § 504.7 Environmental impact statements. (a) General. (1) An environmental impact... environmental impact statements. (1) A draft environmental impact statement (DEIS) will initially be prepared...

  3. 76 FR 63911 - Notice of Intent To Prepare a Draft Environmental Impact Statement/Environmental Impact Report...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-14

    .../Environmental Impact Report (DEIS/DEIR) for a Permit Application for a Proposed Aggregate Terminal Project on..., to develop an aggregate receiving and storage terminal on privately held land within the Port of Long... Rock Aggregates for terminal development and operation. The site, located at 1925 Pier D Street,...

  4. 77 FR 46427 - Notice of Availability for the Draft Environmental Impact Statement/Environmental Impact Report...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-03

    ... Statement/Environmental Impact Report (DEIS/DEIR) for Proposed Aggregate Terminal Project on Pier D in the... the Eagle Rock Aggregates Terminal Project. The proposed project would include the following in- water... owned by L.G. Everist, Inc. and would be leased to Eagle Rock Aggregate, Inc. for terminal...

  5. 76 FR 59119 - Notice of Availability for the Draft Environmental Impact Statement/Environmental Impact Report...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-23

    ... Statement/Environmental Impact Report for Proposed Marine Terminal Development at Pier S and Back Channel... Environmental Impact Statement/Environmental Impact Report (DEIS/DEIR) for the Pier S Marine Terminal and Back... terminal, and would include the following elements: Property acquisition; dredging, wharf...

  6. Visual Motion Perception

    DTIC Science & Technology

    1991-08-15

    an observtr to did not paebrce a vid 3-1) canoes lear to dei-the liv of - pecee .= Be- shape We believe this is a ttrral, ecologicallY -.Ald test of...monoular intion implies that th lou of te Mscdcls2 ca: Cria rdt of apailsiert couasia indiuction is an ca! cotia orbe peeetia ceelllra poultin f.-ooiraaai

  7. 75 FR 43496 - Department of the Army: Intent to Prepare a Draft Environmental Impact Statement for the General...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-26

    ... Engineering Regulation (ER) 1105-2-100, and other applicable Federal and State environmental laws for the... of Engineers Department of the Army: Intent to Prepare a Draft Environmental Impact Statement for the...), is preparing a Draft Environmental Impact Statement (DEIS) to ascertain compliance with and to...

  8. Sardinian Nuraghes

    NASA Astrophysics Data System (ADS)

    Zedda, Mauro Peppino

    This article describes the issues raised by a 20-year research project on the astronomical orientation of nuraghes, the main type of ancient megalithic edifice found in Sardinia. They were constructed during the Bronze Age together with megalithic graves, the so-called "Tombe dei Giganti" ("giants' tombs").

  9. THE DEVELOPMENT OF A QUALITY ASSURANCE PROJECT PLAN FOR THE U.S. EPA DIOXIN EXPOSURE INITIATIVE PROGRAM

    EPA Science Inventory

    All projects planned and implemented under the EPA Dioxin Exposure Initiative (DEI) are required to have completed Quality Assurance Project Plans (QAPPs) EPA Order 5360.1 A2 states, All work funded by the United States Environmental Protection Agency (EPA) that involves the ...

  10. Few-Nucleon Systems

    NASA Astrophysics Data System (ADS)

    Kievsky, A.

    2005-04-01

    Recent advances in the theoretical description of few-nucleon systems are reported. This research activity has been performed under the Italian project FISICA TEORICA DEL NUCLEO E DEI SISTEMI A MOLTI CORPI. Bound and scattering states as well as specific reactions are analyzed in connection with the current experimental activity.

  11. Jose Maria Albareda (1902-1966) and the Formation of the Spanish Consejo Superior de Investigaciones Cientificas

    ERIC Educational Resources Information Center

    Malet, Antoni

    2009-01-01

    Jose Maria Albareda (1902-1966) was an applied chemist and a prominent member of the Roman Catholic organization, Opus Dei, who played a crucial role in organizing the Consejo Superior de Investigaciones Cientficas (CSIC), the new scientific institution created by the Franco regime in 1939. The paper analyses first the formative years in…

  12. 78 FR 66377 - Notice of Intent To Prepare a Draft Environmental Impact Statement on a Proposed Incidental Take...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-05

    ... the proposed Project may include access roads, wind turbine assembly lay down areas, overhead and... statement (DEIS) related to an incidental take permit (ITP) application that Champlin Hawaii Wind Holdings... Makani Project (Project) near Kahuku, Hawaii, for production of wind-generated electrical energy on...

  13. 76 FR 55107 - Draft Environmental Impact Statement for General Management Plan, Gulf Islands National Seashore...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-06

    ... National Park Service Draft Environmental Impact Statement for General Management Plan, Gulf Islands... Availability of the Draft General Management Plan and Environmental Impact Statement. SUMMARY: Pursuant to the... the availability of a Draft Environmental Impact Statement (DEIS) for the General ] Management...

  14. 75 FR 41452 - Withdrawal of the Environmental Impact Statement (EIS) Development Process for the Proposed...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-16

    ... Environmental Impact Statement (DEIS) to address the potential impacts associated with the construction of the... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE Department of the Army, Corps of Engineers Withdrawal of the Environmental Impact Statement (EIS)...

  15. Conceptualising Diversity in a Rural School

    ERIC Educational Resources Information Center

    Tuters, Stephanie

    2015-01-01

    This article describes a qualitative study which investigated how teachers made meaning of and responded to diversity in their rural school. While there is a large amount of information regarding how diversity plays out in urban settings and how teachers respond to it [e.g. Dei, G. J. S., I. M. James, L. L. Karumanchery, S. James-Wilson, and J.…

  16. 75 FR 69434 - Environmental Impacts Statements; Notice of Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-12

    .... 20100441, Second Draft EIS (Tiering), NCPC, DC, Tier-2 DEIS-- Smithsonian Institution National Museum of African American History and Culture (NMAAHC), Construction and Operation, Between 14th and 15th Streets..., Uinta Basin Natural Gas Development Project, To Develop Oil and Natural Gas Resources within...

  17. 78 FR 66900 - Fisheries of the Caribbean, Gulf of Mexico, and South Atlantic; Amendment 28 to the Fishery...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-07

    ...NMFS, Southeast Region, in collaboration with the Gulf of Mexico Fishery Management Council (Council) intends to prepare a DEIS to describe and analyze management alternatives to be included in Amendment 28 to the Fishery Management Plan (FMP) for the Reef Fish Resources of the Gulf of Mexico (Amendment 28). These alternatives will consider measures to reallocate red snapper resources between......

  18. Weight, center of gravity and modal test report for NTF fan blade set no. 3

    NASA Technical Reports Server (NTRS)

    Friedman, Inger P.

    1992-01-01

    A complete set of fan blades for the National Transonic Facility (NTF) at the NASA Langley Research Center was recently fabricated by Dynamic Engineering Inc. (DEI). These blades were the third complete set of blades fabricated by the NTF. The first set of blades was fabricated by NASA and installed in the tunnel in December 1981. This original set was destroyed in a mishap in January 1989. The second set of blades is currently in use in the NTF. The third set of blades recently fabricated by DEI is a spare set. In order to ensure that the blades met the requirements, DEI performed a series of tests on each of the completed blades. In addition, a model survey was conducted on each blade to define the dynamic characteristics. Discussed here are the blade tests conducted by DEI and the test results. The test set-ups and procedures are discussed in detail. The results obtained for each of the 27 blades are documented and comparisons are made between this set of blades and similar data for two previous sets of NTF fan blades.

  19. 75 FR 5282 - Fisheries of the Caribbean, Gulf of Mexico, and South Atlantic; Amendment 32 to the Fishery...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-02

    ...); adjust gag and red grouper annual catch limits (ACLs), annual catch targets (ACTs), and other management measures; and revise shallow-water grouper accountability measures (AMs). In addition, the DEIS will... overfishing and rebuild the stock. For Gulf gag and red grouper, ACLs must be reexamined in light of...

  20. 76 FR 16737 - Notice of Availability of the Draft Environmental Impact Statement for the Proposed South Coast...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-25

    ... Department of Transportation (MassDOT; formerly the Executive Office of Transportation and Public Works or... Draft Environmental Impact Statement (DEIS) to evaluate a proposed establishment of public... Register (73 FR 64927, October 31, 2008). DATES: The Corps will hold two public hearings to...

  1. Developing Resilient Children: After 100 Years of Montessori Education

    ERIC Educational Resources Information Center

    Drake, Meg

    2008-01-01

    In this millennium, educators are faced with a number of issues that Dr. Maria Montessori could not have predicted. Today, students are different from the children Dr. Montessori observed in her "Casa dei Bambini." They are influenced by technology in all its forms. Some suffer from medical problems such as complex food allergies, which wreak…

  2. 78 FR 44521 - Environmental Impact Statement; Proposed Cattle Fever Tick Control Barrier in South Texas

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-24

    ... statement (DEIS) to analyze the effects that may result from installing game fencing as a barrier to keep... fever ticks. Subsequently, we determined that game fencing could help prevent the spread of cattle fever... to contribute funding toward installation of game fencing, with landowner consent and...

  3. Iconicity and Productivity in Sign Language Discourse: An Analysis of Three LIS Discourse Registers

    ERIC Educational Resources Information Center

    Russo, Tommaso

    2004-01-01

    In this article the linguistic features of three Italian Sign Language (Lingua Italiana dei Segni, or LIS) registers are analyzed focusing on iconic phenomena. Previous treatments of iconicity and motivation in spoken and signed language are discussed. Iconicity is defined as a regular mapping between expressive form and meaning that can be active…

  4. Final environmental impact statement/report. Volume 4. Comment letters and public hearing transcripts. Northeast corridor improvement project electrication: New Haven, CT to Boston, MA

    SciTech Connect

    1994-10-01

    This document is the final environmental impact statement and final environmental impact report (FEIS/R) on the proposal by the National Railroad Passenger Corporation (Amtrak) to complete the electrification of the Northeast Corridor main line by extending electric traction from New Haven, CT, to Boston, MA. This document (Volume IV) reprints the comments received on the DEIS/R.

  5. 77 FR 4275 - Notice of Extension of Public Comment Period for Draft Environmental Impact Statement: Rosemont...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-27

    ...: Rosemont Copper Project AGENCY: Forest Service, USDA. ACTION: Notice of extension. SUMMARY: The USDA Forest... Copper Project). The U.S. Environmental Protection Agency (EPA) published a notice of availability (NOA..., comments on the Rosemont Copper Project DEIS will now be accepted through January 31, 2012....

  6. In-laboratory diffraction-enhanced X-ray imaging for articular cartilage.

    PubMed

    Muehleman, Carol; Fogarty, Daniel; Reinhart, Benjamin; Tzvetkov, Tochko; Li, Jun; Nesch, Ivan

    2010-07-01

    The loss of articular cartilage characteristic of osteoarthritis can only be diagnosed by joint space narrowing when conventional radiography is used. This is due to the lack of X-ray contrast of soft tissues. Whereas conventional radiography harnesses the X-ray attenuation properties of tissues, Diffraction Enhanced Imaging (DEI), a novel radiographic technique, allows the visualization of soft tissues simultaneous with calcified tissues by virtue of its ability to not only harness X-ray attenuation but also the X-ray refraction from tissue boundaries. Previously, DEI was dependent upon synchrotron X-rays, but more recently, the development of nonsynchrotron DEI units has been explored. These developments serve to elaborate the full potential of radiography. Here, we tested the potential of an in-laboratory DEI system, called Diffraction-Enhanced X-ray Imaging (DEXI), to render images of articular cartilage displaying varying degrees of degradation, ex vivo. DEXI allowed visualization of even early stages of cartilage degeneration such as surface fibrillation. This may be of eventual clinical significance for the diagnosis of early stages of degeneration, or at the very least, to visualize soft tissue degeneration simultaneous with bone changes.

  7. 78 FR 21703 - Extension of Public Review and Comment Period for the Pyramid Way and McCarran Boulevard...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-11

    ... Federal Highway Administration Extension of Public Review and Comment Period for the Pyramid Way and Mc... Department of Transportation (NDOT), is extending the review and comment period of the DEIS for the Pyramid... available for review at the Spanish Springs Library, 7100A Pyramid Lake Highway, Sparks, NV; the...

  8. Montessori Grows in Tanzania

    ERIC Educational Resources Information Center

    Hoke, Betsy

    2014-01-01

    Imagine going back in time and being the guiding spirit in Montessori's first "Casa dei Bambini" but with all the knowledge and skills developed as a Montessori teacher today. That is precisely the privilege this author has had as, over the past 2 years, she has worked to establish an Early Childhood Montessori program in Usa River,…

  9. Generalizing Galileo's Passe-Dix Game

    ERIC Educational Resources Information Center

    Hombas, Vassilios

    2012-01-01

    This article shows a generalization of Galileo's "passe-dix" game. The game was born following one of Galileo's [G. Galileo, "Sopra le Scoperte dei Dadi" (Galileo, Opere, Firenze, Barbera, Vol. 8). Translated by E.H. Thorne, 1898, pp. 591-594] explanations on a paradox that occurred in the experiment of tossing three fair "six-sided" dice.…

  10. Diagnosis of thyroid multinodular goiter using diffraction-enhanced imaging

    NASA Astrophysics Data System (ADS)

    Rocha, H. S.; Lopes, R. T.; Valiante, P. M.; Tirao, G.; Mazzaro, I.; Hönnicke, M. G.; Cusatis, C.; Giles, C.

    2005-08-01

    Diffraction-enhanced images (DEI) have been obtained using two silicon crystals. A first channel-cut silicon crystal using the Si(3 3 3) reflection is employed to reduce the divergence of the pre-monochromated Si(1 1 1) beam of the light line to 60 microradian (12 arcsec). A second channel-cut Si(3 3 3) crystal was used as a Bragg analyzer to obtain bright and dark field images by changing its angular position. This technique is ideally suited for soft-tissue imaging or objects with the same absorption coefficient interfaces. DEI was developed at the XRD-2 beamline at the Brazilian Synchrotron (LNLS) in Campinas—Brazil. Feasibility tests on acquired images, which allow the diagnosis of thyroid nodular goiter, were performed. This disease is ordinary. The tissue developed on the cervical area causes compression of the nearby structures and undesirable aesthetic deformities with worldwide distribution. DEI of the tissues were taken to observe their morphology and to compare with the microscopic analysis (histopathological). This technique allows cutting sections a hundred times thicker than conventional histological techniques allowing a complete vision of the disease morphology. DEI show details not clearly seen with conventional techniques.

  11. "Fear of Stigmatisation": Black Canadian Youths' Reactions to the Implementation of a Black-Focused School in Toronto

    ERIC Educational Resources Information Center

    Gordon, Megan K.; Zinga, Dawn M.

    2012-01-01

    The black-focused school introduced by the Toronto District School Board (TDSB) in 2009 has been controversial since the community consultations were conducted. Although media representations and Dei (1996, 2006) provide insight into what Torontonians' reactions are to the proposed black-focused school, the reactions of black youth in the Greater…

  12. 76 FR 3655 - Bunker Hill Groundwater Basin, Riverside-Corona Feeder Project, San Bernardino and Riverside...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-20

    ... Bureau of Reclamation Bunker Hill Groundwater Basin, Riverside-Corona Feeder Project, San Bernardino and.../DEIS) for the proposed Riverside-Corona Feeder (RCF) Project. Interested parties are invited to comment..., 555 West 6th Street, San Bernardino, California 92410 Corona Public Library, 650 South Main...

  13. 76 FR 61092 - Notice of Intent To Prepare a Supplement to the Draft Environmental Impact Statement for the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-03

    ...) Notice of Availability (NOA) of this Supplement to the DEIS, and should be addressed to: Naval Facilities... constructing and operating an EHW-2 at Naval Base Kitsap Bangor. A NOA was published in the Federal Register by... (76 FR 24868). The EPA published a NOA revision on May 13, 2011 (76 FR 28029) announcing the...

  14. 75 FR 4537 - Notice of Public Hearings for the Draft Environmental Impact Statement for the Silver Strand...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-28

    ...: Pursuant to section 102(2)(c) of the National Environmental Policy Act (NEPA) and the Council on... and equipment for training, and increased access and availability to existing beach and inland... to receive oral and written comments on the DEIS. An open house session will precede the...

  15. Resonance Capture in Unbalanced Dual-Spin Spacecraft

    DTIC Science & Technology

    1994-03-01

    York, 1989. 22. Wittenburg, Jens. "Beitrige zur dynamik von gyrostaten." In Convegno Inter- nazaionale sul Tema: Metodi Valutativi Nella Fisica ... Matematica , Roma, 15-19 dicembre 1972, Problemi Attuali di Scienza e di Cultura, Quaderno N. 217, pages 217-354. Accademia Nazionale dei Lincei, 1975. 23

  16. A literature review on self-care of chronic illness: definition, assessment and related outcomes.

    PubMed

    Ausili, Davide; Masotto, Matteo; Dall'Ora, Chiara; Salvini, Lorena; Di Mauro, Stefania

    2014-01-01

    INTRODUZIONE. L’assistenza alle persone con malattie croniche rappresenta una sfida per il benessere della popolazione e per la futura sostenibilità dei sistemi sanitari. La promozione del self-care è considerata un aspetto chiave dell’assistenza ai malati cronici. Lo scopo di questa revisione della letteratura è stato quello di esplorare: come il self-care nelle malattie croniche è stato definito dal punto di vista teorico; come il self-care può essere valutato nella pratica clinica e nella ricerca; quali associazioni esistono tra il livello di self-care e i risultati di salute dei pazienti con malattie croniche. RISULTATI. In letteratura si è riscontrata un’ampia gamma di definizioni e terminologie connesse con il self-care nelle malattie croniche. Sebbene nei diversi approcci siano stati identificati alcuni elementi comuni utili a spiegare il concetto di self-care, le variabili fisiche, cognitive, emotive e socioculturali sottese al self-care nelle malattie croniche risultano controverse e scarsamente definite. Un crescente numero di studi ha sviluppato o impiegato strumenti di valutazione del self-care validi ed affidabili per una specifica malattia cronica; tuttavia molti autori riportano la mancanza di utilizzo di strumenti di valutazione nella pratica clinica standard. Un numero limitato di studi ha mostrato delle correlazioni significative tra il self-care nelle malattie croniche e alcune misure di risultato come lo stato generale di salute, la qualità di vita e i costi dell’assistenza sanitaria. CONCLUSIONI. Favorire lo sviluppo del self-care è riconosciuto come un aspetto cruciale dell’assistenza ai malati cronici. Un’analisi più approfondita delle variabili e dei processi che influenzano il self-care potrebbe contribuire ad una più completa descrizione di questo fenomeno. La valutazione sistematica del self-care nella pratica clinica dei professionisti sanitari è fortemente raccomandata. Lo sviluppo di strumenti generali e non

  17. [Modello di Management (Mo.Ma) del paziente affetto da schizofrenia: controllo della crisi, mantenimento, prevenzione delle ricadute e recovery con gli antipsicotici LAI].

    PubMed

    Brugnoli, Roberto; Rapinesi, Chiara; Kotzalidis, Georgios D; Marcellusi, Andrea; Mennini, Francesco S; De Filippis, Sergio; Carrus, Dario; Ballerini, Andrea; Francomano, Antonio; Ducci, Giuseppe; Del Casale, Antonio; Girardi, Paolo

    2016-01-01

    RIASSUNTO. La schizofrenia colpisce circa l'1% della popolazione e rappresenta un grave disturbo mentale con un notevole impatto anche sul funzionamento sociale, lavorativo e sulle attività della vita quotidiana. Le persone con schizofrenia hanno un tasso di mortalità superiore di 2-2,5 rispetto a quello della popolazione generale. La non aderenza ai farmaci antipsicotici è uno dei più importanti fattori di rischio per le ricadute e le ospedalizzazioni, sia nei pazienti con disturbo cronico sia al primo episodio, e conseguentemente contribuisce all'aumento dei costi sanitari. Gli antipsicotici atipici LAI possono migliorare l'aderenza al trattamento contribuendo a diminuire i tassi di ricaduta nei pazienti affetti da schizofrenia fin dall'esordio. Gli obiettivi primari nella gestione dei pazienti schizofrenici sono diretti, non solo alla riduzione dei sintomi nel breve termine, ma anche al mantenimento fisico e della funzionalità mentale, migliorando la qualità della vita e promuovendo il recupero del paziente. Scopo. Proporre un modello integrato, basato sulle evidenze, che fornisca un algoritmo efficace per il recupero del paziente schizofrenico e indagare l'efficacia e la sicurezza degli antipsicotici LAI nel trattamento, nel mantenimento, nella prevenzione delle ricadute e nella recovery dei pazienti affetti da schizofrenia. Metodi. Dopo un'accurata analisi di letteratura abbiamo identificato, raccolto e analizzato gli elementi qualificanti per un'ottimale gestione del paziente schizofrenico, definendo un modello di gestione e selezione delle alternative terapeutiche. Conclusioni. Il modello di gestione della schizofrenia proposto potrebbe consentire un migliore recupero funzionale del paziente grazie alla scelta di iniziare il percorso terapeutico, fin dalle prime fasi del disturbo soprattutto se in giovane età e al primo episodio, con un farmaco atipico LAI. All'interno dei farmaci antipsicotici atipici la formulazione LAI rappresenta una scelta

  18. Post-ERCP pancreatitis. A single center experience and an update on prevention strategies.

    PubMed

    D'Arpa, Francesco; Tutino, Roberta; Battaglia, Emanuele Onofrio; Orlando, Giuseppina; Salamone, Giuseppe; Licari, Leo; Gulotta, Gaspare

    2015-01-01

    La pancreatite rimane ad oggi la maggiore complicanza dell’ERCP nonostante numerose misure tese alla sua prevenzione siano state proposte negli anni. La sua incidenza è del 3.5% e raggiunge in alcune serie di casi anche il 25%; solitamente è lieve-moderata nel 90%. La stratificazione dei pazienti in base al grado di rischio è necessaria per destinare i casi più complessi a centri di terzo livello presenti nel territorio; per far questo, un’analisi dei possibili fattori di rischio è stata originariamente proposta da Freeman ed è poi stata modificata dall’ESGE sulla base dei contributi dei singoli centri, con importanti modifiche. Il presente studio analizza l’incidenza di pancreatite post- ERCP in un centro di terzo livello analizzando, sulla scorta dei fattori di rischio proposti, l’aderenza dei dati. Negli anni 2012-2013, 492 pazienti sono stati sottoposti ad ERCP da due esperti endoscopisti. Secondo le classificazioni di Freeman e Cotton sono state osservate 14 PEP (2.8%), di cui 6 lievi, 4 moderate e 4 severe. È stata condotta un’analisi multivariata che ha evidenziato come fattori di rischio l’elevato numero di tentativi di incannulamento della via biliare e l’iniezione di mezzo di contrasto nel dotto pancreatico; sono risultati fattori protettivi l’early pre-cut e il fallimento della procedura con la sua interruzione. Nella discussione sono state inoltre brevemente analizzate le varie misure profilattiche, quali il posizionamento di protesi pancreatiche e l’utilizzo dei FANS. È interessante notare come i nostri risultati rafforzino gli ultimi orientamenti nel management dell’ERCP, circa l’utilizzo della tecnica di incannulamento filo-guidato e del pre-cut; questi infatti riducono il numero di tentativi di incannulamento ed il conseguente trauma alla papilla promuovendo un incannulamento biliare selettivo e prevenendo l’iniezione di mezzo di contrasto nel dotto pancreatico. Nonostante la pancreatite sia un

  19. Parameters predicting follicular carcinoma in thyroid nodules with indeterminate cytology.

    PubMed

    Kunt, Mevlüt; Cirit, Erkan; Eray, Ismail Cem; Yalay, Orçun; Parsak, Cem Kaan; Sakmann, Gürham

    2015-01-01

    La finalità dello studio è quella di cercare di determinare i parametri indicativi di malignità paragonando caratteristiche demografiche e aspetti di benignità o malignità dei loro noduli determinati sui referti anatomo-patologici dopo tiroidectomia in pazienti con citologia FNAB sospetta per neoplasia follicolare. Lo studio è stato condotto su 152 casi di sospetto carcinoma follicolare in base ai risultati della FNAB. Sono stati presi in considerazione l’età, l’eventuale esposizione a radiazioni, livelli sierici di TSH ed i dati ecografici riguardo al numero, diametro, struttura interna, ecogenicità, caratteristiche dei margini, eventuale presenza di alone e di micro calcificazioni interne. Sono stati anche considerati i rilievi scintigrafici dei noduli. L’età media dei pazienti era 48,14 anni (da 20 a 71); 25 (16,5%) di sesso maschile e 127 (83,5%) femminile. La natura maligna era prevalente tra i pazienti con TSH di livello superiore al normale, che non ai livelli normali o inferiori. La presenza di calcificazioni intranodulari [rapporto differenziale: 3,1; 95% di intervallo di confidenza: 1,3-7,4], aumento della vascolarizzazione intranodulare [rapporto differenziale: 14,7; 95% di intervallo di confidenza: 1,4-147,7], assenza di segni di alone [rapport differenziale: 0,1; 95% di intervallo di confidenza: 0,04-0,8], e margini non ben definiti [rapport differenziale: 0,1; 95% di intervallo di confidenza: 0,49-0,3] erano i dati statisticamente significativi più comuni nei casi di malignità. Su questi dati si può concludere che su basi cliniche e su parametri ecografici è possibile fare previsioni sulla malignità di noduli tiroidei di natura indeterminata, ricordando che l’indagine ecografica è un mezzo semplice, facile e di scarso costo nella diagnostica dei noduli tiroidei.

  20. Predictive value of low tube voltage and dual-energy CT for successful shock wave lithotripsy: an in vitro study.

    PubMed

    Largo, Remo; Stolzmann, Paul; Fankhauser, Christian D; Poyet, Cédric; Wolfsgruber, Pirmin; Sulser, Tullio; Alkadhi, Hatem; Winklhofer, Sebastian

    2016-06-01

    This study investigates the capabilities of low tube voltage computed tomography (CT) and dual-energy CT (DECT) for predicting successful shock wave lithotripsy (SWL) of urinary stones in vitro. A total of 33 urinary calculi (six different chemical compositions; mean size 6 ± 3 mm) were scanned using a dual-source CT machine with single- (120 kVp) and dual-energy settings (80/150, 100/150 Sn kVp) resulting in six different datasets. The attenuation (Hounsfield Units) of calculi was measured on single-energy CT images and the dual-energy indices (DEIs) were calculated from DECT acquisitions. Calculi underwent SWL and the number of shock waves for successful disintegration was recorded. The prediction of required shock waves regarding stone attenuation/DEI was calculated using regression analysis (adjusted for stone size and composition) and the correlation between CT attenuation/DEI and the number of shock waves was assessed for all datasets. The median number of shock waves for successful stone disintegration was 72 (interquartile range 30-361). CT attenuation/DEI of stones was a significant, independent predictor (P < 0.01) for the number of required shock waves with the best prediction at 80 kVp (β estimate 0.576) (P < 0.05). Correlation coefficients between attenuation/DEI and the number of required shock waves ranged between ρ = 0.31 and 0.68 showing the best correlation at 80 kVp (P < 0.001). The attenuation of urinary stones at low tube voltage CT is the best predictor for successful stone disintegration, being independent of stone composition and size. DECT shows no added value for predicting the success of SWL.

  1. The effects of lauromacrogol on thyroid tissue in rabbits. Is this a safe option for the treatment of nodular thyroid disease?

    PubMed

    Idiz, Ufuk Oguz; Aysan, Erhan; Can, Ismail; Buyukpinarbasili, Nur; Yardimci, Erkan Yardimci; Bektasoglu, Huseyin

    2016-01-01

    Lo studio è finalizzato al rilevamento degli effetti del lauromacroglo, un agente sclerosante, sul tessuto tiroideo del coniglio, utilizzando 12 conigli divisi in due gruppi di sei ciascuno. Nel gruppo di studio è stato iniettato nel tessuto tiorideo 0,1 ml di lauromacrogolo, ed in quello di controllo lo stesso volume di soluzione fisiologica. Al controllo postoperatorio sono stati valutati il tasso di FT3, FT4, TSH, la presenza di aderenze e le differenze istopatologiche dei tessuti tiroidei. Non sono risultate differenza significative nel livelli di FT3, FT4, TSH (p>0,05) ma i livelli di , la presenza di aderenze e le differenze istopatologiche dei tessuti tiroidei. Ai controlli i valori di FT3, FT4 ed TSH non sono risultati significativamente differenti (p>0,05), mentre i livelli di FT3 sono stati significativamente differenti all’interno dei due gruppi (p=0,20). Non sono state riscontrate differenze macroscopicamente significative delle aderenze postoperatorie (p>0,05), ma flogosi e fibrosi sono risultate istologicamente più elevate nel gruppo di studio (p=0,003). Due sono i risultati importanti dello studio: la differenza non signifcativa dei test di funzione tiroidea tra i due gruppi, suggerendo che il lauromacrogol può essere usato con sicurezza senza rischi di ipo- o ipertiroidismo; la valutazione istopatologica su modello Erlich-Hunt ha dimostrato che flogosi e fibrosi sono significativamente accresciute nel gruppo di studio, indicando che il lauromacrogol più essere usato efficacemente e con sicurezza per il trattamento dei noduli tiroidei per provocare fibrosi, senza significative aderenze peritiroidee e differenze della funzione.

  2. Evaluating upper versus lower crustal extension through structural reconstructions and subsidence analysis of basins adjacent to the D'Entrecasteaux Islands, eastern Papua New Guinea

    NASA Astrophysics Data System (ADS)

    Fitz, Guy; Mann, Paul

    2013-06-01

    The D'Entrecasteaux Island (DEI) gneiss domes are fault-bounded domes with ~2.5 km of relief exposing ultrahigh-pressure (UHP) and high-pressure (HP) metamorphic gneisses and migmatites exhumed in an Oligocene-Miocene arc-continent collision and subduction zone subject to late Miocene to recent continental extension. Multichannel seismic reflection data and well data show the Trobriand basin formed as a fore-arc basin caused by southward Miocene subduction at the Trobriand trench. Subduction slowed at ~8 Ma as the margin transitioned to an extensional tectonic environment. Since then, the Trobriand basin has subsided 1-2.5 km as a broad sag basin with few normal faults deforming the basin fill. South of the DEI, the Goodenough rift basin developed after extension began (~8 Ma) as the hanging wall of the north-dipping Owen-Stanley normal fault that bounds the basin's southern margin. The lack of upper crustal extension accompanying subsidence in the Trobriand and Goodenough basins suggests depth-dependent lithospheric extension since 8 Ma has accompanied uplift of the DEI gneiss domes. Structural reconstructions of seismic profiles show 2.3-13.4 km of basin extension in the upper crust, while syn-rift basin subsidence values indicate at least 20.7-23.6 km of extension occurred in the entire crust since ~8 Ma. Results indicating thinning is preferentially accommodated in the lower crust surrounding the DEI are used to constrain a schematic model of uplift of the DEI domes involving vertical exhumation of buoyant, postorogenic lower crust, far-field extension from slab rollback, and an inverted two-layer crustal density structure.

  3. [I costi farmacologici della terapia di conversione con farmaci biologici nel carcinoma del colon-retto con metastasi epatiche].

    PubMed

    Giuliani, Jacopo; Bonetti, Andrea

    2016-08-01

    Riassunto. Lo scopo di questo studio è quello di valutare i costi dei farmaci (con particolare riferimento alle terapie con farmaci biologici) utilizzati nella terapia di conversione in una popolazione non selezionata di pazienti affetti da carcinoma del colon-retto in stadio avanzato, al fine di ottenere una resezione epatica R0. In questa rassegna sono stati selezionati i report completi e gli aggiornamenti di tutti gli studi clinici randomizzati (di fase II e fase III) che confrontassero almeno 2 regimi di terapia con farmaci biologici in prima linea in pazienti affetti da carcinoma del colon-retto in stadio avanzato di malattia. I costi dei farmaci sono stati ricavati dalla nostra Farmacia Ospedaliera e sono espressi in euro (€). Il nostro studio inizia con la valutazione di 683 abstract. 48 tria sono stati considerati adeguati per una successiva analisi. Una valutazione più approfondita ha portato all'esclusione di 37 trial, lasciando alla valutazione finale 11 studi clinici randomizzati (3 trial di fase II, per un totale di 522 pazienti, e 8 studi di fase III, per un totale di 7191 pazienti). I costi dei farmaci utilizzati nella terapia di conversione aumentano con la sostituzione del 5-fluorouracile con la capecitabina e, in misura maggiore, con l'introduzione degli agenti biologici. In questo lavoro sono presentati due punti chiave. Primo, i costi degli agenti farmacologici utilizzati nei regimi di prima linea a base di agenti biologici più comunemente utilizzati nel trattamento del carcinoma del colon-retto in stadio avanzato sono molto variabili. Secondo, i dati di efficacia dei regimi pubblicati, in termini di tassi di resezione, dipendono dalla selezione dei pazienti, dalle caratteristiche del tumore e dal tipo di schema di terapia.

  4. Wave front and phase correction for double-ended gauge block interferometry

    NASA Astrophysics Data System (ADS)

    Lassila, A.; Byman, V.

    2015-10-01

    Double-ended interferometry has several benefits over single-ended gauge block interferometry: there is no need for wringing, which wears surfaces and requires expertise, and there is improved repeatability, since there is no variation due to inconsistent wringing conditions or form errors of the gauge block surfaces. Some disadvantages of double-ended interferometry are that absolute phase change correction is needed for the gauge block and its uncertainty has a double effect on total uncertainty. In addition, elimination of the wavefront error is more complicated than with single-ended interferometry. A simple optical modification that enables double-ended interferometer (DEI) measurements with the MIKES interferometer for long gauge blocks is presented. This modification is applicable to almost any single-ended interferometer (SEI). A procedure for evaluating the wave front correction for different parts of the interferogram of DEI is explained, and a modification and software with capability for nine-point phase stepping is presented. Three independent methods for evaluation of the phase correction were studied. One of them uses integrating sphere for the surface roughness correction and literature values for the phase change due to complex refractive index of material correction. The second evaluates the phase correction from the difference between DEI and SEI results obtained with a quartz platen. The third uses differences—from separate measurements—between the results obtained with quartz or steel auxiliary platens. Only a few gauge blocks per set need testing to obtain phase correction. SEI and DEI results with different phase correction determination methods are presented and evaluated. The uncertainty estimate for gauge block calibration with DEI gives a similar standard uncertainty to that with the best SEIs, u=\\sqrt{{{≤ft(10.0~ \\text{nm}\\right)}2}+{{≤ft(118× {{10}-9}L\\right)}2}} .

  5. Non-destructive diffraction enhanced imaging of seeds.

    PubMed

    Young, Lester W; Parham, Christopher; Zhong, Zhong; Chapman, Dean; Reaney, Martin J T

    2007-01-01

    Techniques that make possible the non-destructive continuous observation of plant anatomy and developmental processes provide novel insights into these phenomena. Non-destructive imaging of seeds was demonstrated using the synchrotron-based X-ray imaging technique, diffraction enhanced imaging (DEI). The seed images obtained had good contrast and definition, allowing anatomical structures and physiological events to be observed. Structures such as hypocotyl-root axes, cotyledons, seed coats, air cavities, and embryo-less Brassica napus L. seeds were readily observed using DEI. Embryo axes, scutella, pericarp furrows, coleoptiles, and roots were observable over a time-course in individual germinating Triticum aestivum L. caryopses. Novel anatomical and physiological observations were also made that would have been difficult to make continuously using other techniques. The physical principles behind DEI make it a unique imaging technique. Contrast in DEI is the result of X-ray refraction at the density differences occurring at tissue boundaries, scatter caused by regions containing ordered molecules such as cellulose fibres, and attenuation. Sectioning of samples and the infusion of stains or other contrast agents are not necessary. Furthermore, as high-energy X-rays are used (30-40 keV), little X-ray absorption occurs, resulting in low levels of radiation damage. Consequently, studies of developmental processes may be performed on individuals. Individual germinating B. napus and T. aestivum seeds were imaged at several time points without incurring any apparent radiation damage. DEI offers a unique way of examining plant anatomy, development, and physiology, and provides images that are complementary to those obtained through other techniques.

  6. Along-strike variations in extension from the Woodlark spreading center to mainland Papua New Guinea: New constraints from offshore seismic reflection and well data

    NASA Astrophysics Data System (ADS)

    Fitz, G. G.; Mann, P.; Horton, B. K.

    2010-12-01

    Guy Fitz, Paul Mann, and Brian Horton, Jackson School of Geosciences, University of Texas at Austin, Austin, TX The D’Entrecasteaux Islands (DEI) of eastern Papua New Guinea are composed of high-grade metamorphic domes located within continental crust at the tip of the westward propagating Woodlark spreading ridge. Estimates from Euler pole rotation calculations require ~220 km of extension over ~6 Ma to uplift the DEI domes, the youngest, most recently uplifted metamorphic core complexes on Earth. However, analysis of multi-channel seismic data collected by the RV Maurice Ewing in 1992 and industry seismic data collected in 1974 from offshore basins flanking the DEI domes provides a much lower estimate of 78 + 12 km of upper crust brittle extension in a north-south transect 120 km west of the Woodlark rift area. The WNW alignment of the DEI demarcates two areas of contrasting deformational and depositional histories. In the area of the Kiribisi and Trobriand basins north of the DEI, normal faults occupy a WNW-striking basin of likely forearc origin that rifted in the early Miocene and continued to rift sporadically until the early Pliocene when all normal faults were buried by ~650 m of undeformed Plio-Pleistocene sediments. In Goodenough Basin to the south, the Pleistocene section is thicker and deformed by more recently active, WNW-striking normal faults with seafloor scarps and high-angle dips. The asymmetry of the Goodenough Pleistocene clastic fill near the Owen-Stanley fault along the southern coastline of the bay indicates that most normal motion has now shifted to this fault forming the southern edge of the Goodenough Bay. These seismic data provide no evidence for the OSFZ to be a low-angle normal fault capable of accommodating additional extension. Measurements of upper crust brittle extension in the area are compared to basin stretching factors determined from subsidence analysis and crustal thinning derived from gravity inversion.

  7. Ultrasound examination using contrast agent and elastosonography in the evaluation of single thyroid nodules: Preliminary results.

    PubMed

    Ferrari, F S; Megliola, A; Scorzelli, A; Guarino, E; Pacini, F

    2008-06-01

    Sommario SCOPO: Valutare l'utilità dell'ecografia con ecoamplificatore e dell'elastosonografia nella caratterizzazione del nodulo tiroideo. MATERIALI E METODI: Periodo novembre 2006–luglio 2007, studiati 23 pazienti con nodulo solitario tiroideo, sottoposti a ecografia B-mode e power Doppler, ecografia con mezzo di contrasto, elastosonografia e FNAC (Fine Needle Aspiration Citology). Sedici pazienti sono stati sottoposti a tiroidectomia. RISULTATI: I 23 noduli studiati comprendevano 14 lesioni benigne e 9 maligne. Alla valutazione delle curve intensità/tempo le lesioni maligne presentavano un tempo di wash-in (8,8 ± 1,3 vs 12,1 ± 2,6 secondi; p = 0,002, t-test) e un tempo di picco (15,3 ± 4,6 vs 22,2 ± 3,9 secondi; p = 0,001, t-test) significativamente più precoci rispetto alle lesioni benigne. La fase di wash-out presentava andamento monofasico nel 70% dei noduli benigni e in nessuno dei maligni; polifasico nel 30% dei noduli benigni e nel 100% dei maligni. L'andamento polifasico è associato in maniera statisticamente significativa (p = 0,0007, χ) alla malignità. L'andamento polifasico ha mostrato sensibilità del 100%, specificità del 71%, VPP (valore predittivo positivo) del 69%, VPN (valore predittivo negativo) del 100% e accuratezza diagnostica dell'83%. Nel 78% (11/14) dei noduli benigni sono stati rilevati i pattern elastosonografici 1–2 (maggiore elasticità), nel 88% (8/9) dei noduli maligni i pattern 3–4 (minore elasticità). L'elastosonografia ha mostrato sensibilità dell'88%, specificità del 78%, VPP dell'72%, VPN del 91% e accuratezza diagnostica del 82%. Il pattern elastosonografico 3–4 è associato (p = 0,001, χ) alla malignità. CONCLUSIONI: L'ecografia con ecoamplificatore e l'elastosonografia possono rappresentare ausili diagnostici nella valutazione del nodulo tiroideo solitario, soprattutto quando la FNAC è non diagnostica, quando indica lesione follicolare e nei noduli <1 cm.

  8. Influence of the body mass and visceral adiposity on glucose metabolism in obese women with Pro12Pro genotype in PPARgamma2 gene.

    PubMed

    Kaippert, Vanessa Chaia; Uehara, Sofia Kimi; D'Andrea, Carla Lima; Nogueira, Juliana; do Lago, Márcia Fófano; Cunha Oliveira dos Santos Lopes, Marcelly; Oliveira, Edna Maria Morais; Rosado, Eliane Lopes

    2013-01-01

    Introducción: El metabolismo de la glucosa puede estar alterado en la obesidad y el genotipo del gene PPAR 2 puede influir en este variable. Objetivo: Evaluar la influencia de la masa corporal (MC) y de la adiposidad visceral (AV) en el metabolismo de la glucosa en mujeres con obesidad de grado 3 con el genotipo Pro12Pro. Métodos: Se seleccionaron 25 mujeres con obesidad de grado 3. Se formaron grupos de acuerdo con el índice de masa corporal (IMC) [G1: 40-45 kg/m2 (n = 17), G2: > 45 kg/m2 (n = 8)]. Fueron hechas evaluaciones antropométricas, de la glucemia y de la insulinemia (en ayunas, 60 y 120 minutos después de la comida rica en ácidos grasos poliinsaturados). La resistencia a la insulina (RI) y sensibilidad a la insulina (SI) fueron evaluados por el HOMA-IR y QUICKI, respectivamente. Resultados: G2 tuvieron mayor índice de masa corporal y circunferencia de la cintura, en comparación con G1, peor glucemia en ayunas, baja SI y alta RI. La glucosa postprandial fue normal, pero hubo un pico de insulina más alto una hora después de la comida en G2. Conclusión: El aumento de la MC y de la AV se asociaron con peor metabolismo de la glucosa lo que sugiere diferencias metabólicas entre obesos de grado 3 con el genotipo Pro12Pro.

  9. Metabolism: The Physiological Power-Generating Process: A History of Methods to Test Human Beings' \\"Vital Capacity\\" [Retrospectroscope].

    PubMed

    Johnston, Richard; Valentinuzzi, Max E

    2016-01-01

    A previous "Retrospectroscope" note, published early in 2014, dealt with spirometry: it described many apparatuses used to measure the volume of inhaled and exhaled air that results from breathing [1]. Such machines, when adequately modified, are also able to measure the rate at which work is produced (specifically by an animal or a human being). Metabolism in that sense is the term used by physiologists and physicians, a word that in Greek, metabolismos, means "change" or "overthrow," in the sense of breaking down material, as in burning some stuff.

  10. Changes on metabolic parameters induced by acute cannabinoid administration (CBD, THC) in a rat experimental model of nutritional vitamin A deficiency.

    PubMed

    El Amrani, Loubna; Porres, Jesús M; Merzouki, Abderrahmane; Louktibi, Abdelaziz; Aranda, Pilar; López-Jurado, María; Urbano, Gloria

    2013-01-01

    Introducción: La deficiencia en vitamina A está asociada a la malnutrición, malabsorción de este nutriente, metabolismo alterado de vitaminas por enfermedad hepática, o enfermedades crónicas debilitantes como VIH, cáncer o infección. La administración de cannabis ha sido descrita como una terapia eficaz en el tratamiento sintomático de determinadas manifestaciones de la deficiencia nutricional en vitamina A y de diversas enfermedades crónicas debilitantes. Objetivos: El objetivo de este trabajo era estudiar el efecto de la administración de tetrahidrocannabinol (THC) y cannabidiol (CBD) sobre las concentraciones plasmáticas y hepáticas de retinol y sobre parámetros bioquímicos relacionados con el metabolismo glucídico y lipídico (colesterolemia, trigliceridemia, glucemia) en un modelo experimental de rata deficiente en vitamina A. Métodos: El modelo experimental de deficiencia en vitamina A se desarrolló durante un periodo experimental de 50 días en los que las ratas consumieron una dieta libre en vitamina A. La administración de tetrahidrocannabinol (THC) (10 mg/kg peso corporal) y cannabidiol (CBD) (5 mg/kg peso corporal) se llevo a cabo por vía intraperitoneal 2 horas antes del sacrificio de los animales al final del periodo experimental. Resultados: La deficiencia nutricional en vitamina A causó un descenso significativo en el contenido plasmático y hepático de retinol y en parámetros bioquímicos de metabolismo glucídico, lipídico y mineral. La administración intraperitoneal aguda de tetrahidrocannabinol y cannabidiol no mejoró los índices de estado nutricional de vitamina A en ratas deficientes o control. Sin embargo, tuvo un efecto significativo sobre parámetros bioquímicos específicos como la glucemia, colesterolemia y trigliceridemia. Conclusión: Bajo nuestras condiciones experimentales, el efecto de la administración de cannabinoides sobre determinadas manifestaciones de la deficiencia en vitamina A parece estar

  11. [β-hydroxy-β-methylbutyrate as a dietary supplement (I): metabolism and toxicity].

    PubMed

    Manjarrez-Montes-de-Oca, Rafael; Torres-Vaca, Mateo; González-Gallego, Javier; Alvear-Ordenes, Ildefonso

    2014-11-27

    Introducción: El -hidroxi--metilbutirato (HMB) es un metabolito de la leucina producido a partir del ácido -cetoisocaproico. El HMB se utiliza como suplemento nutricional en el deporte desde 1997, atribuyéndosele una disminución de la proteólisis muscular. En los últimos años, se han descrito efectos positivos del HMB en diversas patologías, lo cual aumenta su probable utilidad para la mejora de la salud. Objetivos: Los objetivos de la presente revisión son: conocer el metabolismo del HMB, así como su absorción y excreción; estudiar la posible toxicidad del HMB; e identificar los mecanismos celulares y moleculares de acción del HMB cuando se utiliza como suplemento nutricional. Métodos: Se utilizaron las bases de datos Web of Science, Pubmed y SportDiscus para realizar la búsqueda de artículos. Los resultados se dividieron en dos partes; en este artículo se abordan el metabolismo y la posible toxicidad del HMB. Resultados: Diversos estudios relacionan al HMB con el metabolismo del colesterol en el músculo esquelético, probablemente reduciendo la proteólisis, a través del 3-hidroxi-3-metilglutaril-coenzima A, que se transforma a mevalonato, actuando como precursor en la síntesis de colesterol. Sin embargo, el HMB podría transformarse en beta-hidroxi-butirato a través del metabolismo del acetoacetato, por medio de la beta-hidroxibutirato dehidrogenasa. Por otra parte, la forma química más habitual en los suplementos nutricionales es la sal de calcio de HMB y la dosis más utilizada, de 3 g de HMB/día. Los estudios realizados en humanos y en animales muestran que no existen efectos adversos por el consumo de HMB. Conclusiones: Los efectos metabólicos y la ausencia de toxicidad del HMB lo hacen adecuado para su uso como suplemento nutricional.

  12. Refraction-contrast tomosynthesis imaging using dark-field imaging optics

    NASA Astrophysics Data System (ADS)

    Sunaguchi, Naoki; Yuasa, Tetsuya; Huo, Qingkai; Ichihara, Shu; Ando, Masami

    2011-09-01

    A soft tissue tomosynthesis imaging system using Laue-case analyzer for dark-field imaging (DFI) optics is described. Two images from which refraction component is deduced are obtained in a single exposure of DFI, while two exposures are required in diffraction enhanced imaging (DEI). The measurement time and radiation dose are thus reduced to half those from DEI. Additionally, the proposed reconstruction algorithm, using only one tenth the number of projections required in computed tomography (CT) imaging, produced images in no way inferior to refraction-contrast CT images. We ex vivo imaged an excised human lung tissue using the system constructed at the KEK vertical wiggler beamline PF-BL14C to demonstrate the proposed imaging protocol efficacy.

  13. Calibrazioni a terra e prestazioni in volo di spettrometri ad immagine nel visibile e nel vicino infrarosso per l'esplorazione planetaria

    NASA Astrophysics Data System (ADS)

    Filacchione, Gianrico

    2006-10-01

    Nel corso dell’ultimo decennio l’esplorazione planetaria ha potuto beneficiare dei dati prodotti dagli spettrometri ad immagine: grazie a questa nuova classe di strumenti, realizzati per l’osservazione in remoto di superfici ed atmosfere planetarie, è possibile acquisire dati iperspettrali con elevati poteri risolutivi spaziali e spettrali. Il principale vantaggio offerto dagli spettrometri ad immagine, rispetto alle camere ed agli spettrometri puntuali, è rappresentato dalla capacità di misurare, identificare e mappare le unità composizionali delle superfici planetarie; queste informazioni permettono di investigare sia l’evoluzione geochimica delle superfici sia la dinamica e la composizione delle atmosfere. Sebbene i primi spettrometri ad immagine siano stati francesi (Phobos/ISM, Imaging Spectrometer for Mars) e statunitensi (Galileo/NIMS, Near Infrared Mapping Spectrometer), il nostro paese nel corso degli ultimi anni è stato in grado di proporre alla com unità spaziale internazionale degli strumenti dalle elevate prestazioni che sono stati infatti accettati come payload scientifici su diverse missioni interplanetarie: dai canali visibili di VIMS (Visual and Infrared Mapping Spectrometer) su Cassini (Nasa, JPL, ESA, ASI) e di OMEGA (Observatoire pour la Minéralogie, l’Eau, les Glacies et l’Activitè de Mars) su MarsExpress (ESA) ai due VIRTIS (Visible and Infrared Thermal Imaging Spectrometer) su Rosetta (ESA) e VenusExpress (ESA) fino a VIR-MS (Visible and Infrared Mapping Spectrometer) su Dawn (Nasa). In questo momento inoltre altri due spettrometri sono in avanzata fase di studio: JIRAM (Jovian InfraRed Auroral Mapper) su Juno (missione New Discovery Nasa) e VIHI (Visible and Infrared Hyperspectral Imager) integrato nel payload italiano di remote sensing SIMBIO-SYS di BepiColombo (missione cornerstone ESA). La realizzazione di uno spettrometro ad immagini da utilizzare su una missione interplanetaria richiede un’accurata analisi in fase

  14. Surface Uplift and Disequilibrium Fluvial Geomorphology of Metamorphic Core Complexes in the D'Entrecasteaux Islands and Dayman-Suckling Massif, Papua New Guinea

    NASA Astrophysics Data System (ADS)

    Miller, S. R.; Baldwin, S. L.; Fitzgerald, P. G.

    2008-12-01

    Structural, thermobarometric, geochronological, and thermochronological evidence suggests that the D'Entrecasteaux Islands (DEI) and the Dayman-Suckling massif (DSM), in southeastern Papua New Guinea, are metamorphic core complexes, which have been exhumed from depths as great as 90 km over the past 2- -8 Ma, possibly because of microplate rotation. The dome-shaped DEI and DSM reach elevations of ~2500 m and ~3500 m, respectively, however little is known about their kinematic histories since their emergence above sea level in the Plio-Pleistocene. Detachment faults are commonly corrugated or dip- slope surfaces occurring in various states of dissection. The question of whether faults bounding the DEI domes are active today remains debated, yet has implications for what mechanisms have exhumed the core complexes as well as where and how active rifting in the Woodlark rift is accommodated. In order to provide a regional overview and direct future tectonic geomorphic studies, we conducted a stream profile analysis of the DEI and DSM using a 3-arc-second Shuttle Radar Topography Mission digital elevation model. Footwall stream profiles in the study area are characterized by large knickpoints across which stream gradients steepen downstream by a factor of 2. These knickpoints are not typically associated with mapped lithologic contacts or faults and occur in all lower plate lithologies. Therefore, we interpret the knickpoints as transients formed as the result of a Quaternary region-wide increase in rock uplift rate or a decrease in stream erodibility. Model profiles extrapolated from relict reaches above knickpoints project to former base levels 40- -1600 m above sea level, indicating similar amounts of incision and rock uplift. Although the timing of knickpoint initiation is not tightly constrained and may vary throughout the region, estimates of profile uplift measured this way correlate linearly with normalized stream steepness index (ksn) below knickpoints

  15. Spanish Summary (Nuevos meteoritos encountrados en lmilac)

    NASA Astrophysics Data System (ADS)

    1987-03-01

    Desde tiempos prehistoricos han sido coleccionadas piedras que caen dei cielo. Hasta hace poco eran la unica fuente para hacer estudios de laboratorio de la materia extragal, ktica, e incluso en nuestra era espacial, siguen siendo una valiosa fuente de investigacion de la temprana historia dei sistema solar. Se estima que como termine medio cada kilometro cuadrado de la superficie terrestre es golpeada cada millon de aiios por un meteorito con un pese superior a 500 gramos. La mayoria se pierden en los oceanos 0 caen en regiones con escasa poblacion. Como resultado, los museos en el munda reciben anualmente tan solo alrededor de 6 meteoritos cuya caida fuera atestiguada. Otros llegan por hallazgos casuales que en la mayoria de los casos son meteoritos que han cardo en tiempos prehistoricos.

  16. Public participation in energy facility siting. Part 1; Case study results

    SciTech Connect

    Whitlatch, E.E. . Dept. of Civil Engineering); Aldrich, J.A. ); Cristo, M. )

    1990-08-01

    The objective of this paper is to determine to what extent public participation has been effective in influencing recent energy-facility siting (EFS) decisions for nuclear and coal-fired power plants in the Ohio River Basin. Licensing requirements, review procedures, and criteria were studied for six basin states, along with utility-siting criteria and siting methodologies. Six case study power plants (four coal-fired and two nuclear) were investigated in detail. It is concluded that the current regulatory/adjudicatory EFS process is not conducive to meaningful public participation for a wide range of reasons, which include: lack of public involvement during the crucial early site screening stage; lack of public information during the long draft environmental impact statement (DEIS) stage; the negative effect on public trust caused by site purchase and limited site work before issuance of the DEIS; and siting methodologies that heavily emphasize technological criteria.

  17. Parkinson's disease patients with bilateral subthalamic deep brain stimulation gain weight.

    PubMed

    Macia, Frédéric; Perlemoine, Caroline; Coman, Irène; Guehl, Dominique; Burbaud, Pierre; Cuny, Emmanuel; Gin, Henri; Rigalleau, Vincent; Tison, François

    2004-02-01

    Weight, body mass index (BMI) and energy expenditure/energy intake (EE/EI) was studied in 19 Parkinson's disease (PD) patients after subthalamic deep brain stimulation (STN-DBS) versus 14 nonoperated ones. Operated patients had a significant weight gain (WG, + 9.7 +/- 7 kg) and BMI increase (+ 4.7 kg/m2). The fat mass was higher after STN-DBS. Resting EE (REE; offdrug/ON stimulation) was significantly decreased in STN-DBS patients, while their daily energy expenditure (DEI) was not significantly different. A significant correlation was found among WG, BMI increase, and pre-operative levodopa-equivalent daily dose, their reduction after STN-DBS, and the differential REE related to stimulation and the REE in the offdrug/OFF stimulation condition. In conclusion, STN-DBS in PD induces a significant WG associated with a reduction in REE without DEI adjustment.

  18. Deep burn of hand and forearm treated by abdominal wall flap. A case report.

    PubMed

    Chiummariello, Stefano; Del Torto, Giuseppe; Maffia, Romano; Pataia, Elisabetta; Alfano, Carmine

    2015-06-24

    Le ustioni della mano sono sempre state uno dei maggiori problemi per i chirurghi ricostruttori a causa della sua particolare anatomia e delle sue complesse funzioni. Una guarigione spontanea di lesioni profonde in queste aree può portare a risultati catastrofici: una copertura cutanea adeguata è fondamentale per tutte le funzioni. La copertura precoce dei tessuti molli residuanti è fondamentale al fine di evitare la formazione di contratture disabilitanti che con il tempo potrebbero determinare anchilosi articolare e retrazione tendinea. Escissione precoce e innesti cutanei rappresentano la terapia standard per le ustioni della mano; in alcuni casi quest’approccio è inapplicabile e, pertanto, il ricorso ai lembi diventa inevitabile. In questo articolo riportiamo un caso di ustione complessa del dorso della mano trattata in prima istanza con innesti cutanei e, quindi, con un lembo addominale, riuscendo ad ottenere un’ottima copertura ed un buon recupero delle funzioni.

  19. Studio delle popolazioni di blazar ad alte energie

    NASA Astrophysics Data System (ADS)

    Gasparrini, D.; Giommi, P.

    2008-10-01

    Utilizzando la grande quantita' di dati sui blazar disponibile ad oggi, e' possibile costruire una distribuzione spettrale di energia (SED) media per ciascuna classe di oggetti. Basandosi su un modello SSC, e' inoltre possibile stimare il comportamento di questi oggetti nella banda di energia dei raggi gamma partendo dalle informazioni ottenute da osservazioni in altre bande di energia quali il radio e l'X. Utilizzando le simulazioni sara` possibile prevedere un eventuale cambio di popolazione dominante ad alte energie(oltre 1GeV) rispetto a quanto avviene in banda radio dove domina la popolazione dei FSRQ rispetto ai BL Lac e cercare un'eventuale conferma dagli esperimenti AGILE e GLAST.

  20. VII Workshop Italiano sulla fisica pp a LHC

    NASA Astrophysics Data System (ADS)

    LHCpp2016 è la settima edizione dell'incontro nazionale sulla fisica p-p a LHC. Questa serie di incontri è nata a Pisa nel 2003 con lo scopo di stimolare lo scambio di idee tra le comunità sperimentali di ATLAS, CMS e LHCB e la comunità teorica. Caratteristica fondamentale di questi incontri è la preparazione di larga parte dei talk in collaborazione tra i vari esperimenti e la comunità teorica. Largo spazio nella preparazione e presentazione dei talk viene dato ai giovani ricercatori. In questa settima edizione, che si tiene di nuovo a Pisa, vogliamo concentrare l'attenzione sulle potenzialità di scoperta offerte dai dati raccolti durante il runII di LHC.

  1. Proposed Tenaska Washington II Generation Project : Final Environmental Impact Statement. Volume 2: Public Involvement.

    SciTech Connect

    United States. Bonneville Power Administration.

    1994-01-01

    In regard to the proposed Tenaska Washington II Generation Project, the goal of the Bonneville Power Administration`s (BPA) Environmental Impact Statement (EIS) public involvement process is to determine the issues to be examined and pertinent analyses to be conducted and to solicit comments on the content and quality of information presented in the Draft Environmental Impact Statement (DEIS). Comments and questions are solicited from the public and government agencies during the scoping process and during the comment period and public hearing on the DEIS, to find out what is of most concern to them. The end product of the public involvement process is the Comment Report which follows in part of this volume on Public Involvement.

  2. Ultraviolet Communication for Medical Applications

    DTIC Science & Technology

    2014-05-01

    addressability. The scheme required 3-D electrode patterns with a printed resistive layer and, if the scheme proves to be manufacturable, a small-area emitter...shell array that emits UVA light at 350 nm wavelength. These shells were hand-painted with the required conductive and resistive inks. Drive... transmitter and receiver pointing angles were automated with servos to enable automated outdoor channel testing. Finally, DEI purchased and implemented

  3. INRiM Time and Frequency Laboratory: A New Data Management System (DMS)

    DTIC Science & Technology

    2010-11-01

    protocols defined at international level. The INRIM TFL, at present, is equipped with a set of measuring and control devices (SAD – Sistema di...Proceedings of the 22 th European Frequency and Time Forum (EFTF), 22-25 April 2008, Toulouse, France. [2] G. Vizio, 2000, “ Sistema per l’acquisizione...dei dati del Laboratorio di Tempo e Frequenza,” Manuale Operativo INRIM – 2000. [3] R. Costa, D. Orgiazzi, G. C. Cerretto, and V. Pettiti, 2010

  4. Ultraviolet Communication for Medical Applications

    DTIC Science & Technology

    2015-06-01

    AWARD NUMBER: W81XWH-12-C-0043 TITLE: Ultraviolet Communication for Medical Applications PRINCIPAL INVESTIGATOR Jeff Guy Directed Energy , Inc...SUPPLEMENTARY NOTES Report contains color. 14. ABSTRACT Under this Phase II SBIR effort, Directed Energy Inc.’s (DEI) proprietary ultraviolet (UV...non-line-of-sight (NLOS) optical communication data links operating in the solar blind region (200–280 nm). The intended application is covert

  5. [National epidemiological surveillance systems of mesothelioma cases].

    PubMed

    Ferrante, Pierpaolo; Binazzi, Alessandra; Branchi, Claudia; Marinaccio, Alessandro

    2016-01-01

    INTRODUZIONE: sebbene la relazione causale tra esposizione ad amianto e malattie neoplastiche sia ben nota, in molti Paesi il consumo del materiale è ancora rilevante e crescente. A causa della lunga latenza, nei Paesi dove è stato bandito (come in Italia) è oggi in corso un'epidemia di malattie correlate ad amianto. OBIETTIVI: descrivere i sistemi di sorveglianza dei mesoteliomi attivi nel mondo mediante un'analisi comparativa.

  6. Oyster Shell Dredging in Atchafalaya Bay and Adjacent Waters, Louisiana. Volume 2. Public Comments.

    DTIC Science & Technology

    1987-11-01

    Dredging in Atchafalaya Bay and Adjacent Waters, Louisiana. We appreciate the opportunity to review the DEIS. Sincerely yours, David Cottinginm Ecology ...subsequent effects on the aquatic ecosystem . General evaluation and testing procedures are outlined in the 404(b)(1) guidelines [Section 230.60 of Subpart G3...does not include zones 4-9 as integral parts of the regional ecosystem . The overall cummulative impact to the biology of the region can only be

  7. MX Missile MOA Between Four Corners Regional Commission and the United States Air Force.

    DTIC Science & Technology

    1981-08-20

    related to construction or operation of MX? 4-562 1 The first cost of installing of alternative energy sources (photo- voltaics , etc.) was not stated. 4...level and the comments on the MX DEIS and ETRs are enclosed. Task 12. Citizen Advisory Committees As reported in the First Quarter Report for 81...be on line during the first part of July and will greatly increase this office’s capability to disseminate information. The acquisition of a word

  8. A Holistic Management Architecture for Large-Scale Adaptive Networks

    DTIC Science & Technology

    2007-09-01

    MANAGEMENT ARCHITECTURE FOR LARGE-SCALE ADAPTIVE NETWORKS by Michael R. Clement September 2007 Thesis Advisor: Alex Bordetsky Second Reader...TECHNOLOGY MANAGEMENT from the NAVAL POSTGRADUATE SCHOOL September 2007 Author: Michael R. Clement Approved by: Dr. Alex ...achieve in life is by His will. Ad Majorem Dei Gloriam. To my parents, my family, and Caitlin: For supporting me, listening to me when I got

  9. Designing Bare Base Systems for Logistics Efficiency in the Joint Operational Environment

    DTIC Science & Technology

    2007-12-01

    Production Daniel Armstrong, Cover Design Please send inquiries or comments to Editor The Wright Flyer Papers Air Command and Staff College (ACSC/ DEI ) 225...Freedom (Arlington, VA: RAND Cor­ poration, 005), 47. . Ibid., 58–59. 3. Alex Szumanski, Report to AF/ILGM: Force Provider and BEAR Equipment...Proposed_Force_Provider _Company_Redesign.htm. Szumanski, Alex . Report to AF/ILGM: Force Provider and BEAR Equipment Compatibility Study. N.p. Tripp, Robert S

  10. A Genetic Approach to Identifying Signal Transduction Mechanisms Initiated by Receptors for TGF-B-Related Factors.

    DTIC Science & Technology

    1998-10-01

    resistant to TGF-ß-induced growth arrest suggest that both types of receptors are required for signaling (Boyd and Massague, 1989; Laiho et ah, 1990...II in TGF-ß- resistant cell mutants implicates both receptor types in signal transduction. J. Biol. Chem. 265, 18518-18524. Lechleider, R. J., de...I-1 « -J AD GRANT NUMBER DAMD17-94-J-4339 TITLE: A Genetic Approach to Identifying Signal Transduction Mechanisms Initiated by Receptors

  11. [Mortality from respiratory diseases in the provinces of Apulia Region (Southern Italy) from 1933 to 2010].

    PubMed

    Montinari, Maria Rosa; Gianicolo, Emilio Antonio Luca; Vigotti, Maria Angela

    2016-01-01

    OBIETTIVI: valutare l'andamento temporale della mortalità per patologie respiratorie nelle province pugliesi utilizzando dati omogenei per fonte e metodologia di calcolo. DISEGNO: analisi ecologica storica degli andamenti temporali di mortalità per tumori e patologie dell'apparato respiratorio nelle province pugliesi, in Puglia e nelle ripartizioni geografiche italiane dal 1933 al 2010. SETTING E PARTECIPANTI: i dati di mortalità e le popolazioni residenti sono di fonte Istat. Sono state esaminate tutte le cause di decesso, il tumore della laringe, il tumore del polmone, l'insieme dei tumori respiratori, la bronchite, la polmonite e la broncopolmonite considerate congiuntamente, e l'insieme delle patologie respiratorie. Le analisi sono disaggregate per sesso dal 1969. PRINCIPALI MISURE DI OUTCOME: rapporti standardizzati di mortalità (SMR%) in riferimento all'Italia, con intervalli di confidenza al 95%, e tassi di mortalità standardizzati col metodo diretto (TSD ) in riferimento alla popolazione standard europea. RISULTATI: dal 1933 al 2010, i TSD per tumori respiratori e per bronchiti diminuiscono in tutte le aree analizzate. Tuttavia, nelle province di Taranto, Brindisi e Lecce, l'SMR% per tumori respiratori, inferiore al riferimento nazionale fino agli anni Sessanta, si allinea (a Brindisi) e supera (a Lecce e Taranto) il riferimento negli anni successivi. Nelle province di Foggia e Bari il numero dei decessi per tumore del polmone è costantemente inferiore all'atteso. CONCLUSIONI: la ricostruzione storica e l'analisi dei trend temporali di mortalità dal 1933 al 2010 mostrano alcune criticità sanitarie in periodi specifici. L'elaborazione dei dati di mortalità per un arco temporale di circa 80 anni ha messo in evidenza la maggiore rilevanza di queste criticità con l'avvio dello sviluppo industriale.

  12. Final Environmental Impact Statement. F-15E Beddown at Seymour Johnson AFB, North Carolina

    DTIC Science & Technology

    1988-11-18

    which firelighters illegally kill deer at night. We believe that a potential I for laser safety regarding wildlife, especially those species which may be...during daylight hours, aerial observation of deer firelighters at night is one of the most efficient techniques for 114 detection and apprehension...affect our ability to accomplish our mission. The i DEIS should address impacts on enforcement flights for detection and apprehension of firelighters as

  13. Search for meteorites around Kamil crater and preliminary radiometric measurements

    NASA Astrophysics Data System (ADS)

    Di Martino, M.; Taricco, C.; Colombetti, P.; Cora, A.; Mancuso, S.

    About 1600 kg of iron meteorite fragments were found in and around the Kamil impact crater by an Italian-Egyptian geophysical team in February 2009 and February 2010. Two samples of the Gebel Kamil meteorite (one shrapnel and a piece of the only one individual that has been found) were measured at Monte dei Cappuccini Laboratory (INAF) in Torino, using a selective gamma spectrometer and 26Al cosmogenic activity was detected in both fragments.

  14. Percutaneous ultrasound-guided treatment of shoulder tendon calcifications: Clinical and radiological follow-up at 6 months().

    PubMed

    De Conti, G; Marchioro, U; Dorigo, A; Boscolo, N; Vio, S; Trevisan, M; Meneghini, A; Baldo, V; Angelini, F

    2010-12-01

    Sommario INTRODUZIONE: La tendinopatia calcifica di spalla è una condizione relativamente frequente caratterizzata, quando sintomatica, da dolore cronico e da fasi di dolore acuto molto intenso. MATERIALI E METODI: Da ottobre 2006 a marzo 2008 abbiamo trattato 126 spalle di 125 pazienti consecutivi. Tutti hanno eseguito Rx ed ecografia prima del trattamento ed il test di Constant prima del trattamento e a 6 mesi di distanza. 55 pazienti su 123 (42%) sono stati trattati due o più volte con infiltrazione intrabursale di corticosteroide. Tre pazienti hanno rifiutato altri trattamenti dopo il primo. Sono stati quindi raccolti i dati complessivamente di 123 spalle. È stata eseguita RM di controllo a sei mesi. RISULTATI: Incremento del Constant Score dopo la procedura in tutti i pazienti trattati una sola volta ed in quasi tutti i pazienti trattati due volte; i pazienti sono stati divisi in due classi, rispettivamente trattati una o due (o più) volte. In ciascuna delle due classi c’è stato un significativo incremento (p < 0,0001)delle medie dei Cs pre e post trattamento; nella classe dei pazienti trattati due volte significatività statistica (p < 0,0001) tra le medie dei Cs rispettivamente prima del trattamento iniziale e dopo il primo trattamento, e tra la media Cs di quest’ultimo e quella dopo 6 mesi dal primo trattamento. Il Cs dopo il trattamento è significativamente diverso nei pazienti con impingement (p < 0,001). CONCLUSION: Incremento del Cs, in più del 95% dei pazienti. Non lesioni tendinee ai controlli ecografici/RM. L’impingement è risultato un fattore di rischio per il risultato finale.

  15. M-X Environmental Technical Report. Socioeconomic Impact Estimates for Texas ROI Counties. Detailed Tables.

    DTIC Science & Technology

    1980-12-22

    and identify by block number) MX Socioeconomic Impact Siting Analysis Texas Ř 20. ABSTRACT (Continue on reveree aide If necessary end Identify by...block number) The detailed socioeconomic impacts reported in this volume form background information for the analysis contained in the M-X Deployment...information for the analysis contained in the M-X Deployment Area Selection and Land Withdrawal/Acquisition Draft Environmental Impact Statement (DEIS

  16. European Scientific Notes. Volume 39, Number 1.

    DTIC Science & Technology

    1985-01-01

    at millimeter-wave frequencies states--X, Y, and Z. These substates between 40 and 100 GHz (Webb, 1969; differ in energy, if the molecular sym...aerodynam- ONR, London, report R-11-84 ics, meteorology, and molecular science, examines developments in the program -0 Preliminary results, as reported by...per la Corrosione Marina dei results have been obtained with an epoxy Metalli Reparto di Biologia Marina, Con- base paint containing 30 percent ZnO

  17. Few-Nucleon Systems

    NASA Astrophysics Data System (ADS)

    Viviani, Michele

    The recent theoretical advances in the study of the statical and dynamical properties of few-nucleon systems are here reported, with particular attention to the research activities performed under the Italian MURST-PRIN project FISICA DEL NUCLEO E DEI SISTEMI A PIÙ CORPI. The latter studies also include the development of methods for dealing with pionic degrees of freedom, the determination of static properties of light nuclei, and the computation of few-nucleon reaction observables, including electroweak processes.

  18. Individual Differences in Vigilance and Performance During Continuous/Sustained Operations

    DTIC Science & Technology

    2002-11-01

    Casagrande Dipartimento di Psicologia UniversitA degli Studi di Roma "La Sapienza" Via dei Marsi, 78 -00185 Roma, Italy Aeronautica Militare Italiana...8217based. approach, Journal of Personality and Social Psychologv. 56, 267-283. Casagrande M, Violani C, Curcio G., Bertini M. (1997) Individual differences...Multidimensional assessment of coping: A critical evaluation. Journal of Personality and Social Psychology. 58: 844-854. Evans FJ, Cook MR, Cohen HD, Ome EC

  19. Ho-doped Soft Glass Optical Fibers for Coherent Wavelength Sources Above 2 Micron

    DTIC Science & Technology

    2010-12-01

    Politecnico di Torino – Dipartimento di Scienza dei Materiali e Ingegneria Chimica Corso Duca degli Abruzzi, 24 – 10129 Torino Italia tel: +39...Abruzzi, 24 – 10129 Torino Italia tel: +39 011 564 4707 fax: +39 011 564 4699 e-mail: daniel.milanese@polito.it url: www.composites.polito.it...Materiali e Ingegneria Chimica Corso Duca degli Abruzzi, 24 – 10129 Torino Italia tel: +39 011 564 4707 fax: +39 011 564 4699 e-mail

  20. 78 FR 27956 - Fisheries of the Caribbean, Gulf of Mexico, and South Atlantic; Amendment 39 to the Fishery...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-13

    ...NMFS, Southeast Region, in collaboration with the Gulf of Mexico Fishery Management Council (Council) intends to prepare a DEIS to describe and analyze a range of alternatives for management actions to be included in Amendment 39 to the Fishery Management Plan (FMP) for the Reef Fish Resources of the Gulf of Mexico (Amendment 39). The purpose of this NOI is to inform the public of upcoming......

  1. Final environmental impact statement/report. Volume 3. Response to comments on draft environmental impact statement/report. Northeast corridor improvement project electrification: New Haven CT to Boston, MA

    SciTech Connect

    1994-10-31

    This document is the final environmental impact statement and final environmental impact report (FEIS/R) on the proposal by the National Railroad Passenger Corporation (Amtrak) to complete the electrification of the Northeast Corridor main line by extending electric traction from New Haven, CT, to Boston, MA. This document (Volume III) of the FEIS/R presents summaries of comments received on the DEIS/R and responses to these comments.

  2. Final environmental impact statement/report. Volume 2. Technical studies. Northeast corridor improvement project electrification: New Haven, CT to Boston, MA

    SciTech Connect

    1994-10-01

    This document is the final environmental impact statement and final environmental impact report (FEIS/R) on the proposal by the National Railroad Passenger Corporation (Amtrak) to complete the electrification of the Northeast Corridor main line by extending electric traction from New Haven, CT, to Boston, MA. This document (Volume II) presents additional technical studies to supplement Volume III of the DEIS/R issued in October 1993 (PB94-111838).

  3. Nonoperative management for major blunt hepatic trauma. A case report.

    PubMed

    Mingoli, Andrea; Saracino, Andrea; Brachini, Gioia; Mariotta, Giovanni; Migliori, Emanuele; Silvestri, Vania

    2015-03-16

    Negli ultimi 20 anni il trattamento del trauma epatico chiuso si è modificato radicalmente passando da una gestione quasi costantemente chirurgica ad una non operativa in tutti i casi in cui non vi siano le condizioni di instabilità emodinamica o di variazione nella clinica del paziente traumatizzato. A tutt’oggi però non è raro osservare un approccio a tale condizione clinica seguendo criteri che la Medicina Basata sull’Evidenza dimostra essere superati. Presentiamo in questo lavoro il caso clinico di una donna di 34 anni che subiva un trauma diretto della regione postero-laterale dell’emitorace destro cadendo accidentalmente da una scala. Nonostante la gravità della lesione evidenziata dalla TC (IV grado secondo AAST Liver Injury Scale), si è optato per un trattamento non operativo data la condizione di stabilità emodinamica ottenuta con un primo bolo di cristalloidi. Una complicanza di tipo respiratorio ha complicato il quadro in terza giornata dal trauma richiedendo una toracentesi e dei cicli di ventilazione non invasiva. A 4 anni di distanza dal trauma la paziente sta bene e non lamenta disturbi. La letteratura mostra che il trattamento conservativo viene impiegato oggi in oltre l’85% dei traumi epatici, indipendentemente dall’entità della lesione. Il successo del trattamento conservativo varia nelle diverse casistiche dall’82% al 100% dei casi, e le sue complicanze, quando si verificano (14% dei traumi maggiori) possono spesso essere trattate con procedure di radiologia interventistica, evitando ancora l’intervento chirurgico. Oggi, in assenza di altre lesioni addominali che richiedano l’esplorazione chirurgica, l’indicazione al trattamento operativo è solo l’instabilità emodinamica del paziente che persiste o si ripresenta subito dopo un corretto trattamento rianimatorio iniziale.

  4. Dynamic Models Including Uncertainty

    DTIC Science & Technology

    2009-01-22

    least in part with this grant) • H.T. Banks, Prof ., North Carolina State University • G. M. Kepler, Res. Assoc, North Carolina State University • S...8217W- C -( ( »II 2 »P] i=i i’=i - N m nEE d 2{a2p) 2tttid^y ’tax dei N N EE WP) (4.19) 4.2.9 Finite Difference Scheme for Fokker

  5. East Bay Marina Olympia, Thurston County, Washington. Final Detailed Project Report, Section 107, 1960 River and Harbor Act and Environmental Impact Statement

    DTIC Science & Technology

    1980-12-01

    Alternative 4’ s , Alternative 4e is the only one that should be seriously considered for development . 4. Water quality impacts due to dredging. The DEIS does...other development projects. Sincerely, Ron Arens Director, Olympia Downtown Development Program RA:vc cc: Port of Olympia H-77 1063 S . Capital Way...3. RECIPIENT’S CATALOG NUMBER 4. TITLE (And Subtitle) East Bay Marina, Olympia, Thurston s . TYPE OF REPORT & PERIOD COVERED tounty, Washington: Final

  6. Septic complications involving hand and wrist in patients with pre-existing rheumatoid arthritis: The role of magnetic resonance imaging and sonography.

    PubMed

    Bortolotto, C; Gregoli, B; Coscia, D R; Draghi, F

    2012-06-01

    Sommario SCOPO DEL LAVORO: L'artrite settica (SA), che spesso coinvolge mano e polso, è comune nei pazienti con artrite reumatoide (AR) a causa dell'eziologia immunomediata della AR e dell'uso di farmaci immunosoppressivi. Le caratteristiche cliniche e di laboratorio possono non essere utili per distinguere tra recidiva di AR e sovrapposizione di SA. Il ruolo della risonanza magnetica (RM) è stata descritto in diversi studi. Il nostro obiettivo è quello di valutare il ruolo della ecografia (US). Materiali e Metodi. Negli ultimi 4 anni sono stati eseguiti 31 esami di risonanza magnetica della mano e del polso nel sospetto di SA come complicanza di AR. È stata utilizzata una risonanza magnetica da 1.5 T (Siemens Symphony, Erlangen, Germania) con protocollo standardizzato, che comprendeva la somministrazione di mezzo di contrasto; è stata eseguita anche un'ecografia con power Doppler utilizzando un ecografo Philips IU22. RISULTATI: Sono stati analizzati undici punti (secondo lo studio di Graif) per ogni esame di RM e di US. Alla RM il versamento articolare (37,5% di recidiva AR vs 100% sovrapposizioni di SA) e l'edema dei tessuti molli (25% vs 100%) erano indicativi di SA. Anche ecograficamente il versamento articolare (31.3% di AR recidiva 73,3% vs sovrapposizione di SA) e l'edema dei tessuti molli (12,5% vs 60%) erano indicativi di SA. CONCLUSIONE: I nostri risultati confermano che il versamento articolare e l'edema dei tessuti molli sono suggestivi per sovrapposizione di SA e che la RM è più sensibile nella loro valutazione. Anche se l'US è meno sensibile della RM, essa è importante nel guidare procedure invasive e nella valutazione dei pazienti che non possono essere sottoposti a RM.

  7. Course of acute pancreatitis in diabetic patients.

    PubMed

    Koziel, Dorota; Gluszek, Stanislaw; Osuch, Martyna Gluszek

    2016-01-01

    Negli anni recenti in molti paesi europei si è dimostrata una crescente incidenza della pancreatite acuta (AP), ed alcuni studi indicano un aumento di rischio di AP nei pazienti diabetici. Questo studio è pertanto finalizzato a valutare il decorso clinico della AP nei pazienti diabetici. Sono stati studiati tutti i pazienti curati in reparto chirurgico per una diagnosi di AP identificando come pazienti diabetici quelli che all’anamnesi hanno confermato essere affetti da diabete di tipo 1 o di tipo 2 prima di essere ricoverati per AP. I pazienti ricoverati per AP, ed arruolati nello studio sono stati 963, e tra essi vi erano 87 (9%) diabetici. Tra questi ultimi erano più numerosi quelli portatori di calcolosi biliare quale causa della pancreatite (46% vs 32%). Nella maggioranza dei casi il decorso della AP è stato di gravità moderata, ma comunque nel 10,3% dei pazienti con diabete il decorso della malattia è stato moderatamente grave, e nel 12,7% decisamente grave. Non sono state osservate differenze nella mortalità da AP in entrambi i gruppi. Insufficienza sistemica è stata osservata più frequentemente nel gruppo dei diabetici di tipo 2 (5,4%) e 23,1% in quelli di tipo 2, a fronte del 5,1% dei pazienti non diabetici, con differenze statisticamente non significative. In conclusione l’incidenza della AP nei pazienti diabetici aumenta con l’età, ed è più spesso correlata con la calcolosi biliare. In questo gruppo di pazienti in decorso clinico è èiù frequentemente grave, con insufficienza sistemica nei diabetici di tipo 1.

  8. Immunological Prevention of Spontaneous Mammary Carcinoma in Transgenic Mice

    DTIC Science & Technology

    2001-08-01

    developed more slowly by transgenic FVB Anatomia Patologica, Ospedale S.S. Annunziata, Via Valignani, 66100 female mice carrying the wild-type proto...coopted (Pezzella et al., 1997). Anatomia Patologica. Ospedale SS. Annunziata, Via Valignani, 66100 Chieti, Italy. Fax: 39 0871 330471. E-mail: musiani...lo Studio e la Cura dei Tumori, Milan, Italy; and Reprints: Piero Musiani, G. d’ Annunzio University of Chieti, Anatomia Department of Experimental

  9. Study of the Physics of Insulating Films as Related to the Reliability of Metal-Oxide-Semiconductor (MOS) Devices

    DTIC Science & Technology

    1982-02-01

    and DEIS 112-13-20,21 were 4-port devices of the type illustrated in (c). AP . A, and A, were 7.7 x 10-7, 1.0 X 10". and 4.8 x 10-6 for Cl-21-. 1.6 x 10...sites after electron capture. 98 29 a -COULOMBIC ATTRACTIvE 1 Ec-E HOTk Figre7. chmatc eprsetatonof otntil nery istibtio fr () colobq atrcie b eurl n C

  10. Condensed Phase Membrane Introduction Mass Spectrometry with Direct Electron Ionization: On-line Measurement of PAHs in Complex Aqueous Samples

    NASA Astrophysics Data System (ADS)

    Termopoli, Veronica; Famiglini, Giorgio; Palma, Pierangela; Cappiello, Achille; Vandergrift, Gregory W.; Krogh, Erik T.; Gill, Chris G.

    2016-02-01

    Polycyclic aromatic hydrocarbons (PAHs) are USEPA regulated priority pollutants. Their low aqueous solubility requires very sensitive analytical methods for their detection, typically involving preconcentration steps. Presented is the first demonstrated `proof of concept' use of condensed phase membrane introduction mass spectrometry (CP-MIMS) coupled with direct liquid electron ionization (DEI) for the direct, on-line measurement of PAHs in aqueous samples. DEI is very well suited for the ionization of PAHs and other nonpolar compounds, and is not significantly influenced by the co-elution of matrix components. Linear calibration data for low ppb levels of aqueous naphthalene, anthracene, and pyrene is demonstrated, with measured detection limits of 4 ppb. Analytical response times (t10%-90% signal rise) ranged from 2.8 min for naphthalene to 4.7 min for pyrene. Both intra- and interday reproducibility has been assessed (<3% and 5% RSD, respectively). Direct measurements of ppb level PAHs spiked in a variety of real, complex environmental sample matrices is examined, including natural waters, sea waters, and a hydrocarbon extraction production waste water sample. For these spiked, complex samples, direct PAH measurement by CP-MIMS-DEI yielded minimal signal suppression from sample matrix effects (81%-104%). We demonstrate the use of this analytical approach to directly monitor real-time changes in aqueous PAH concentrations with potential applications for continuous on-line monitoring strategies and binding/adsorption studies in heterogeneous samples.

  11. Cosine fitting radiography and computed tomography

    NASA Astrophysics Data System (ADS)

    Li, Pan-Yun; Zhang, Kai; Huang, Wan-Xia; Yuan, Qing-Xi; Wang, Yan; Ju, Zai-Qiang; Wu, Zi-Yu; Zhu, Pei-Ping

    2015-06-01

    A new method in diffraction-enhanced imaging computed tomography (DEI-CT) that follows the idea developed by Chapman et al. [Chapman D, Thomlinson W, Johnston R E, Washburn D, Pisano E, Gmur N, Zhong Z, Menk R, Arfelli F and Sayers D 1997 Phys. Med. Biol. 42 2015] in 1997 is proposed in this paper. Merged with a “reverse projections” algorithm, only two sets of projection datasets at two defined orientations of the analyzer crystal are needed to reconstruct the linear absorption coefficient, the decrement of the real part of the refractive index and the linear scattering coefficient of the sample. Not only does this method reduce the delivered dose to the sample without degrading the image quality, but, compared with the existing DEI-CT approaches, it simplifies data-acquisition procedures. Experimental results confirm the reliability of this new method for DEI-CT applications. Project supported by the National Basic Research Program of China (Grant No. 2012CB825800), the National Natural Science Foundation of China (Grant Nos. 11205189, 11375225, and U1332109), the Knowledge Innovation Program of the Chinese Academy of Sciences (Grant Nos. KJCX2-YW-N42, Y4545320Y2, and 542014IHEPZZBS50659).

  12. Short photoperiod increases energy intake, metabolic thermogenesis and organ mass in silky starlings Sturnus sericeus

    PubMed Central

    WANG, Jia-Qi; WANG, Jia-Jia; WU, Xu-Jian; ZHENG, Wei-Hong; LIU, Jin-Song

    2016-01-01

    Environmental cues play important roles in the regulation of an animal’s physiology and behavior. One such cue, photoperiod, plays an important role in the seasonal acclimatization of birds. It has been demonstrated that an animal’s body mass, basal metabolic rate (BMR), and energy intake, are all affected by photoperiod. The present study was designed to examine photoperiod induced changes in the body mass, metabolism and metabolic organs of the silky starling, Sturnus sericeus. Captive silky starlings increased their body mass and BMR during four weeks of acclimation to a short photoperiod. Birds acclimated to a short photoperiod also increased the mass of certain organs (liver, gizzard and small intestine), and both gross energy intake (GEI) and digestible energy intake (DEI), relative to those acclimated to a long photoperiod. Furthermore, BMR was positively correlated with body mass, liver mass, GEI and DEI. These results suggest that silky starlings increase metabolic thermogenesis when exposed to a short photoperiod by increasing their body and metabolic organ mass, and their GEI and DEI. These findings support the hypothesis that bird species from temperate climates typically display high phenotypic flexibility in thermogenic capacity. PMID:27029864

  13. Effects of cold therapy in the treatment of mandibular angle fractures: hilotherm system vs ice bag.

    PubMed

    Barca, Ida; Colangeli, Walter; Cristofaro, Maria Giulia; Giudice, Amerigo; Giofrè, Elio; Varano, Anna; Giudice, Mario

    2016-01-01

    La crioterapia dopo interventi di chirurgia maxillo-facciale è una metodica comunemente utilizzata sia a fini analgesici che di riduzione dell’edema e dell’ecchimosi dei tessuti molli. Hilotherapy è costituito da un’unità mobile elettrica refrigerante dotata di un termostato digitale regolabile e da un circuito chiuso di acqua distillata refrigerata che scorre all’interno di collettori e di maschere in gomma specificatamente conformate per i distretti anatomici del massiccio facciale. Abbiamo selezionato 40 pz affetti da frattura unifocale di angolo mandibolare e suddivisi in 2 gruppi, crioterapia con ice-bag (gruppo A) e Hiloterapy System (Gruppo B); entrambi sottoposti a medesimo trattamento farmacologico di base (antibiotico-antiedemigeno-antidolorifico). L’analisi dei dati ha dimostrato come l’utilizzo dell’Hiloterapy System nel post-operatorio per 48 ore a temperatura modulata ha garantito un più rapido decremento dell’edema dei tessuti molli e un miglior controllo del dolore, con conseguente minor richiesta di farmaci anti-infiammatori ed anti-dolorifici, rispetto al gruppo A.

  14. Short photoperiod increases energy intake, metabolic thermogenesis and organ mass in silky starlings Sturnus sericeus.

    PubMed

    Wang, Jia-Qi; Wang, Jia-Jia; Wu, Xu-Jian; Zheng, Wei-Hong; Liu, Jin-Song

    2016-03-18

    Environmental cues play important roles in the regulation of an animal's physiology and behavior. One such cue, photoperiod, plays an important role in the seasonal acclimatization of birds. It has been demonstrated that an animal's body mass, basal metabolic rate (BMR), and energy intake, are all affected by photoperiod. The present study was designed to examine photoperiod induced changes in the body mass, metabolism and metabolic organs of the silky starling, Sturnus sericeus. Captive silky starlings increased their body mass and BMR during four weeks of acclimation to a short photoperiod. Birds acclimated to a short photoperiod also increased the mass of certain organs (liver, gizzard and small intestine), and both gross energy intake (GEI) and digestible energy intake (DEI), relative to those acclimated to a long photoperiod. Furthermore, BMR was positively correlated with body mass, liver mass, GEI and DEI. These results suggest that silky starlings increase metabolic thermogenesis when exposed to a short photoperiod by increasing their body and metabolic organ mass, and their GEI and DEI. These findings support the hypothesis that bird species from temperate climates typically display high phenotypic flexibility in thermogenic capacity.

  15. Multiple-Image Radiography for Human Soft Tissue

    SciTech Connect

    Muehleman,C.; Li, J.; Zhong, Z.; Brankov, J.; Wernick, M.

    2006-01-01

    Conventional radiography only provides a measure of the X-ray attenuation caused by an object; thus, it is insensitive to other inherent informative effects, such as refraction. Furthermore, conventional radiographs are degraded by X-ray scatter that can obscure important details of the object being imaged. The novel X-ray technology diffraction-enhanced imaging (DEI) has recently allowed the visualization of nearly scatter-free images displaying both attenuation and refraction properties. A new method termed multiple-image radiography (MIR) is a significant improvement over DEI, corrects errors in DEI, is more robust to noise and produces an additional image that is entirely new to medical imaging. This new image, which portrays ultra-small-angle X-ray scattering (USAXS) conveys the presence of microstructure in the object, thus differentiating homogeneous tissues from tissues that are irregular on a scale of micrometers. The aim of this study was to examine the use of MIR for evaluation of soft tissue, and in particular to conduct a preliminary investigation of the USAXS image, which has not previously been used in tissue imaging.

  16. [Health expenditure for prevention in Italy (2006-2013): descriptive analysis, regional trends and international comparisons].

    PubMed

    Signorelli, Carlo; Odone, Anna; Bianco, Daniela; Di Vivo, Natalia; Bevere, Francesco

    2016-01-01

    Il dato dell'Organizzazione per la cooperazione e lo sviluppo economico (OCSE) del 2012, che indicava l'Italia come il Paese con la più bassa spesa in prevenzione sanitaria, ha dato lo spunto per una raccolta sistematica e un'analisi critica dei flussi disponibili sulla spesa per le attività di prevenzione in Italia. Le statistiche correnti di spesa sanitaria sono raccolte centralmente dall'Agenzia nazionale per i servizi sanitari regionali (Agenas) attraverso i modelli di rilevazione dei costi dei livelli essenziali di assistenza (LEA) delle aziende USL. Le tre macroaree dei LEA sono: assistenza distrettuale, assistenza ospedaliera e assistenza sanitaria collettiva in ambiente di vita e di lavoro. Le spese per la prevenzione rientrano in quest'ultima e sono ripartite nelle seguenti voci: attività di prevenzione rivolte alle persone, igiene degli alimenti e della nutrizione, igiene e sanità pubblica, prevenzione e sicurezza negli ambienti di lavoro, sanità pubblica veterinaria, attività medico-legale per finalità pubblica. Tra il 2006 e il 2013, ultimo dato disponibile, la spesa per le attività di prevenzione del Servizio sanitario nazionale (SSN) è rimasta costante in rapporto alla spesa sanitaria totale (4,2%), pari a 4,9 miliardi nel 2013. Nel periodo di studio considerato (2006-2013) appaiono in aumento le spese per le attività rivolte alle persone (+8,7%), attribuibili soprattutto a vaccinazioni e screening, e in diminuzione le attività di igiene pubblica (-5,7%) e quelle della sanità pubblica veterinaria (-3,8%). I confronti internazionali indicano una spesa per la prevenzione del 2,9% rispetto alla spesa sanitaria totale, costante negli anni e nella media dei Paesi OCSE. Per la prevenzione, l'Italia spende tanto quanto i Paesi che non possiedono un servizio sanitario pubblico; il dato risulta inferiore del 5% rispetto alla programmazione nazionale, con poche eccezioni e molta variabilità regionale all'interno delle componenti delle voci di spesa

  17. Tools For Interactive Learning And Self-Management Of Diabetes

    NASA Astrophysics Data System (ADS)

    Capelo, Rita; Baptista, Carla; Figueiredo, Júlia; Carrilho, Francisco; Furtado, Pedro

    2015-05-01

    Diabetes is a widespread disease and its control is dependent upon the patient. Although there is no permanent cure for diabetes, there are several available treatments which, when followed regularly, allow the patient to have a good quality of life. Patient education, especially about eating habits, is key to keep glucose levels stable both in the short and in the long term. This should include nutritional counselling, physical exercise, and the self monitoring of glucose levels. The University of Coimbra and the Serviço de Endocrinologia, Diabetes e Metabolismo of Centro Hospitalar e Universitário de Coimbra started a collaboration to develop interactive tools for the learning and improvement of carbohydrate counting by patients. The approach presented in this paper is an interactive multimedia tool, available to patients through either the web or a smartphone. It helps them to learn how to maintain a healthy diet and how to monitor their insulin levels correctly by measuring the carbo-hidrate “equivalents” in meals. This application will create a more dynamic and interactive way of educating patients, improving solutions currently used in the Serviço de Endocrinologia, Diabetes e Metabolismo of the Centro Hospitalar e Universitário de Coimbra.

  18. PubMed

    López Gómez, Juan José; Pérez Castrillón, José Luis; Romero Bobillo, Enrique; De Luis Román, Daniel A

    2016-11-29

    La obesidad interfiere con el metabolismo óseo a través de factores mecánicos, hormonales e inflamatorios. El principal tratamiento de dicha enfermedad es la dieta, modificación de la cantidad y tipo de alimento. Este tratamiento nutricional tiene una influencia sobre el metabolismo óseo en dos sentidos: modifica el efecto del sobrepeso y la obesidad sobre el hueso e interviene directamente en el turnoveróseo a través de las características de los nutrientes utilizados. Esta revisión analiza la evidencia del efecto sobre el hueso del descenso de peso y del patrón dietético utilizado. Por otra parte, se valorarán las modificaciones que se pueden realizar en la dieta indicada en un paciente obeso para prevenir la pérdida ósea, a corto y largo plazo, y disminuir el riesgo de fractura.

  19. [Metabolism of N-acetyl-L-aspartate: its diagnostic and prognostic value].

    PubMed

    Martinez, Manuel A; Florenzano, Néstor V; Macchia, Esteban A

    2016-04-16

    Objetivos. Analizar la implicacion clinica del aminoacido N-acetil-L-aspartato (NAA) y el peptido N-acetil-aspartil-glutamato (NAAG) en relacion con su valoracion diagnostica y pronostica mediante espectroscopia de resonancia magnetica. Realizar una revision del metabolismo del NAA y del NAAG, considerando su estructura quimica y fisiologia, en relacion con las variaciones de su concentracion y en correlacion con la clinica. Desarrollo. La revision se divide en dos partes: en una se comprobo que el unico sitio de sintesis del NAA es la mitocondria neuronal, y del NAAG, el citoplasma neuronal; la segunda parte aborda las tecnicas de resonancia magnetica y, particularmente, la espectroscopia. Se analizan diversas patologias en busca de criterios que posibiliten obtener pautas diagnosticas y pronosticas. Conclusiones. El estudio del aminoacido mas abundante del sistema nervioso central (NAA) junto con un producto de su metabolismo, el NAAG, permite en patologias de diversos origenes su diagnostico y seguimiento y facilita la obtencion de datos de densidad de la poblacion celular y vitalidad de esta, de manera que se accede, ademas, al estado funcional de las sinapsis.

  20. NOVEL INSIGHTS ON INTAKE OF MEAT AND PREVENTION OF SARCOPENIA: ALL REASONS FOR AN ADEQUATE CONSUMPTION.

    PubMed

    Rondanelli, Mariangela; Perna, Simone; Faliva, Milena Anna; Peroni, Gabriella; Infantino, Vittoria; Pozzi, Raffaella

    2015-11-01

    Introducción: la sarcopenia se define como un síndrome caracterizado por la pérdida progresiva y generalizada de la masa muscular y de la fuerza. La principal causa de la sarcopenia es la alteración del metabolismo de las proteínas, en la que los procesos proteolíticos no van acompañados de una síntesis de proteínas y células musculares adecuadas, con lo que se pierde progresivamente la sensibilidad al estímulo anabólico. El enfoque más racional para retrasar la progresión de la sarcopenia y contrarrestar la resistencia anabólica es una nutrición adecuada. La carne contiene compuestos biológicamente activos, tales como creatina, carnitina y ácido linoleico conjugado (CLA) que tienen impactos significativos sobre el metabolismo de la proteína humana. Métodos: se realizó una revisión de la literatura narrativa para evaluar la evidencia hasta ahora, en relación con: 1. ingesta adecuada de carne en ancianos como prevención de la sarcopenia; 2. la ingesta correcta de compuestos biológicamente activos que contiene la carne, que tienen impactos significativos sobre el metabolismo de la proteína humana y para así obtener efectos beneficiosos en la prevención de la sarcopenia. Esta revisión incluyó 62 estudios elegibles. Resultados: los resultados demostraron que en personas de edad avanzada la terapia óptima con dieta para la prevención y tratamiento de la sarcopenia, que debe apuntar al logro de los objetivos metabólicos específicos, debe recomendar el consumo de 113 g de carne (220 kcal; 30 g de proteínas) cinco veces a la semana. Conclusión: en una dieta variada y equilibrada, para prevenir la sarcopenia, se recomienda consumir la carne 4-5 veces a la semana (carne blanca 2 veces por semana, carne roja magra menos de 2 veces por semana, carne procesada menos de 1 vez por semana), como se sugiere en la pirámide de la dieta para personas mayores.

  1. Effect of conjugated linoleic acid mixtures and different edible oils in body composition and lipid regulation in mice.

    PubMed

    Scalerandi, María Victoria; Gonzalez, Marcela Aida; Saín, Juliana; Fariña, Ana Clara; Bernal, Claudio Adrián

    2014-03-01

    Introducción: Las evidencias sugieren que las mezclas de Ácido Linoleico Conjugado (ALC) de origen comercial o natural diferencialmente afectan diferencialment al estado nutricional y al metabolismo lipídico. Objetivo: Investigar el efecto de dos preparaciones de ALC como complemento de grasas dietarias con diferentes proporciones de ácidos grasos (AG) n-9, n-6 y n-3 sobre composición corporal, niveles de triacilglicéridos (TG) y metabolismo lipídico en ratones. Métodos: Se alimentó a ratones en crecimiento con dietas con aceite de oliva, maíz y canola, o colza suplementadas con una mezcla equimolecular de ALC (mezcla-ALC) o aceites ricos en ácido ruménico (AR) por 30 días. Se evaluó: ganancia de peso, composición corporal, peso de tejidos, niveles de TG plasmáticos y séricos, y parámetros de regulación lipídica. Resultados: Independientemente de las grasas dietarias, la mezcla-ALC redujo el peso corporal y depósitos grasos relacionados con hepatomegalia, incremento de TG séricos y descenso de TG musculares. El aceite de canola previno la esteatosis hepática producida por la mezcla-ALC a aceites de oliva y maíz por incremento de la secreción de TG. AR decreció los depósitos grasos sin hepatomegalia, esteatosis hepática e hipertrigliceridemia. Aceite de oliva previno el incremento de TG musculares inducidos por suplementación con AR al aceite de maíz y canola. Discusión y conclusión: Las proporciones de AG insaturados dietarios modularon la respuesta de mezcla-ALC y AR al metabolismo lipídico en ratones. Finalmente, aceite de canola previno la esteatosis hepática inducida por mezcla-ALC, y los efectos benéficos más notorios fueron observados cuando aceite de oliva fue suplementado con AR, debido a la reducida acreción de lípidos sin cambios en los niveles de TG.

  2. High-oleic peanuts increase diet-induced thermogenesis in overweight and obese men.

    PubMed

    Duarte Moreira Alves, Raquel; Boroni Moreira, Ana Paula; Silva Macedo, Viviane; Brunoro Costa, Neuza Maria; Gonçalves Alfenas, Rita de Cássia; Bressan, Josefina

    2014-05-01

    Antecedentes: Las pruebas sugieren que el consumo de frutos secos puede mejorar el metabolismo energético. Propósito: Este estudio tenía por finalidad comparar los efectos de la ingesta aguda de cacahuetes con alto contenido en oleico y cacahuetes convencionales sobre el apetito, el consumo de alimentos y el metabolismo energético in hombres con sobrepeso y obesos. Métodos: Se distribuyó a 71 individuos (29,8 ± 2,4 kg/m2) a los grupos: control (CT, n = 24); cacahuetes convencionales (CVP, n = 23); cacahuetes con alto contenido en oleico (HOP, n = 24). Los individuos consumieron 56 g de cacahuetes (CVP y HOP) o control (CT) tras un ayuno nocturno. Posteriormente, se evaluó el metabolismo energético a lo largo de 200 minutes, durante los cuales se analizaron la termogénesis inducida por la dieta (TID) y la oxidación de sustratos. La sensación de apetito se registró durante 3 horas. Se realizaron los análisis estadísticos con el programa SAS considerando un nivel de significación del 5%. Resultados: El consumo de energía posprandial y la TID fueron significativamente superiores en el HOP que el CVP. La oxidación de sustratos no difirió entre los grupos. Sólo el HOP presentó una puntuación por debajo de 100, lo que indicaba una compensación incompleta. El CT y el CVP mostraron una compensación calórica completa (puntuaciones > 100). Con respecto a la sensación de apetito, el grupo CVP se mostró menos “lleno” que los grupos HOP y CT. A las 3 horas, la puntuación de saciedad del CVP volvió a la situación basal, mientras que en los grupos HOP y CT permanecía significativamente superior. Las puntuaciones de hambre volvieron a la situación basal in los grupos CVP y CT y se mantuvieron significativamente por debajo a las del grupo HOP. Conclusión: Los cacahuetes con alto contenido en oleico contribuyen a una mayor TID, mayor sensación de plenitud y una compensation incompleta del consumo de energía en comparación con los cacahuetes

  3. Assessment of body composition, through anthropometric and non-anthropometric methods, of university students from valencia (Spain).

    PubMed

    Olearo, Beatrice; Soriano Del Castillo, Jose Miguel; Boselli, Pietro Marco; Micó Pascual, Lydia

    2014-10-01

    Introducción y objetivo: La valoración del estado antropométrico y nutricional de la población universitaria es importante para detectar grupos de riesgo y realizar recomendaciones nutricionales. El objetivo fue analizar la composición corporal y el porcentaje de grasa en un grupo de estudiantes universitarios y evaluar su metabolismo basal para ver si había una correlación con la composición corporal. El estudio se llevó a cabo a través de diferentes métodos, para determinar si los resultados obtenidos son comparables. Sujetos y método: La muestra fueron 16 alumnos (4 hombres y 12 mujeres) de la Universidad de Valencia, 20- 33 años de edad. A todos se hizo el estudio de la composición corporal y a 6 de ellos se hizo también un estudio metabólico. Resultados: Se encontró que el 75% de los sujetos estudiados tienen un peso normal, el 12,5% tienen bajo peso y 12,5% tiene sobrepeso. El porcentaje de sujetos con grasa corporal superior a los valores normales son: 68,75% según BFMNU, el 25% a través del método ISAK y 7,69% según BIA. Conclusiones: Nuestro estudio mostró que los datos obtenidos a través de los diferentes métodos no son directamente comparables, ya que se basan en diferentes principios y supuestos. También se ha observado la importancia de considerar no sólo la masa grasa, si no toda la composición corporal para tener una visión completa del sujeto. Además, se ha podido notar que la calorimetría indirecta y las ecuaciones de predicción del metabolismo basal no son capaces de estimarlo correctamente. En cambio el método BFMNU es el que da más información y permite investigar a fondo el metabolismo.

  4. Metabolic disorders of liver and iron in diabetic and non-diabetic patients BMI < 35 or > 35 before gastric bypass.

    PubMed

    Garcíacaballero, Manuel; Reyes-Ortiz, Alexander; Martínez-Moreno, José Manuel; Toval-Mata, José Antonio

    2014-05-01

    Introducción: La presencia de anormalidades en las vías metabólicas del hierro y el funcionamiento del hígado pueden producir resistencia a la insulina o síndrome metabólico. Por lo tanto, es importante examinar esas alteraciones que pueden conducir al desarrollo de enfermedades. El estado nutricional es otro factor importante que está íntimamente ligada a la diabetes y la obesidad. Pacientes y métodos: Se estudiaron 131 pacientes (78 pacientes no diabéticos y 53 diabéticos), 37 pacientes IMC ≤35 (3 IMC < 25, 18 IMC 25-29,9, 16 IMC 30-34,9) y 94 pacientes IMC ≥35 (81 IMC 35-49,9 y 13 de IMC ≥50). Los sujetos fueron sometidos a estudios de laboratorio relacionadas con el funcionamiento del hígado y el metabolismo del hierro. Se determinó también el estado nutricional en nuestros pacientes. Resultados: El hierro estuvo alterado en 14% de los pacientes IMC >35 y los diabéticos alcanzaron 3% a 25%. La vitamina B12 fue baja en 4% de los no diabéticos IMC > 35, y alta en el 6% de los diabéticos IMC < 35. El 6% de los diabéticos IMC < 35 tenía hiperbilirrubinemia. Las transaminasas estuvieron elevadas en pacientes IMC > 35, pero exacerbados en los diabéticos. GGT se eleva del 41% al 47% en BMI > 35. ALP estuvo elevada en el 25% de los diabéticos. Las proteínas séricas totales y la albúmina estuvieron alterados en los diabéticos causando desnutrición leve. 90% de los pacientes tenían una nutrición normal y 10% desnutrición leve. Conclusiones: El metabolismo hepático y del hierro están estrechamente relacionadas con el inicio de la obesidad y la diabetes. Si hay un aumento de peso, los riesgos metabólicos acumulados se elevan. La presencia de la diabesidad y el aumento de la duración de la diabetes empeoran el metabolismo. El estado nutricional se altera en la obesidad, pero es peor con la adición de la diabetes.

  5. [Compassionate nursing care: the experience of italian nurses].

    PubMed

    De Carlo, Paola; Guerra, Denise; Rega, Maria Luisa; Galletti, Caterina

    2016-01-01

    Scopo. Nella letteratura infermieristica internazionale compassion e compassionate care hanno assunto una notevole importanza e si rivelano essere un fenomeno in divenire. Il concetto di compassionate nursing care risulta poco descritto ed oggettivato nella pratica infermieris-tica nel nostro Paese. Scopo di questo studio è stato di descrivere le esperienze di un campione di infermieri italiani circa il significato di cure infermieristiche compassionevoli. Metodo. È stato condotto uno studio qualitativo. Per la raccolta dei dati sono stati utilizzati i focus group, per analizzare i dati trascritti è stata utilizzata l’analisi di contenuto. Per lo studio è stato individuato un campione propositivo di 21 infermieri, di questi 15 hanno dato la disponibilità a partecipare. Risultati e discussione. Tutti i partecipanti hanno espresso liberamente le loro opinioni. Dall’analisi dei dati relativi alle quattro aree indagate con i focus group: definizione, la propria esperienza, tipologie di pazienti e formazione alle cure infermieristiche compassionevoli sono emersi aspetti contrastanti che variano da accezioni negative e negazione dei termini stessi a significati positivi di amore, carità, empatia, supporto, sostegno, relazione. Interessante ed innovativo è stato l’attribuire l’insegnamento delle cure compassionevoli ai parenti. Conclusioni. E’ risultato difficile per i partecipanti dare una definizione precisa sul significato di cure infermieristiche compassionevoli. E’ emersa la necessità e il desiderio di approfondire questo tema che risulta essere originale e un punto di forza per migliorare l’assistenza infermieristica. Infatti, puntare al recupero di questi valori educando gli infermieri ad erogare cure infermieristiche compassionevoli può sicuramente rappresentare un’implicazione futura per la professione.

  6. Real-time elastography in the diagnosis of prostate tumor.

    PubMed

    Ferrari, F S; Scorzelli, A; Megliola, A; Drudi, F M; Trovarelli, S; Ponchietti, R

    2009-03-01

    Sommario SCOPO: Verificare il guadagno diagnostico dell'elastosonografia transrettale real-time (RTE) rispetto alla ecografia transrettale B-mode nel rilievo del tumore prostatico in una popolazione di pazienti con sospetto di neoplasia. MATERIALI E METODI: Ottantaquattro pazienti con sospetto clinico-laboratoristico di tumore prostatico sono stati valutati mediante ecografia transrettale, elastosonografia e biopsia transperineale. RISULTATI: L'esame bioptico è stato considerato lo standard di riferimento. Nella valutazione per paziente, la sensibilità dell'ecografia B-mode è stata del 56%; la specificità dell'80%; il valore predittivo positivo (VPP) del 70%, il valore predittivo negativo (VPN) del 67%. Nella valutazione sul totale dei prelievi bioptici la sensibilità è stata del 33%, la specificità del 92%, il VPP del 69%, il VPN del 73%. La RTE ha ottenuto i seguenti risultati nella valutazione per paziente: sensibilità 51%, specificità 75%, VPP 64% e VPN 64%. Nella valutazione sul totale dei prelievi bioptici: sensibilità 36%, specificità 93%, VPP 72%, VPN 74%. Confrontando i valori di accuratezza dell'ecografia B-mode e della RTE per i tumori della zona periferica, è stata trovata una differenza significativa. Nella valutazione sul totale dei prelievi bioptici della zona periferica la sensibilità dell'ecografia B-mode è stata del 48%, la specificità dell'81%, il VPP del 75%, il VPN del 58%. La RTE ha ottenuto i seguenti valori: sensibilità 66%, specificità 78%, VPP 77%, VPN 67%. CONCLUSIONI: La RTE rappresenta un valore aggiunto all'ecografia B-mode. Ha presentato un'accuratezza superiore rispetto all'esame B-mode nella valutazione della prostata periferica e nella possibilità di indirizzare i prelievi bioptici.

  7. Highly sensitive detection of the soft tissues based on refraction contrast by in-plane diffraction-enhanced imaging CT

    NASA Astrophysics Data System (ADS)

    Yuasa, Tetsuya; Hashimoto, Eiko; Maksimenko, Anton; Sugiyama, Hiroshi; Arai, Yoshinori; Shimao, Daisuke; Ichihara, Shu; Ando, Masami

    2008-07-01

    We discuss the recently proposed computed tomography (CT) technique based on refractive effects for biomedical use, which reconstructs the in-plane refractive-index gradient vector field in a cross-sectional plane of interest by detecting the angular deviation of the beam, refracted by a sample, from the incident beam, using the diffraction-enhanced imaging (DEI) method. The CT has advantages for delineating biological weakly absorbing soft tissues over the conventional absorption-contrast CT because of the use of phase sensitive detection. The paper aims to define the imaging scheme rigidly and to demonstrate its efficacy for non-destructive measurement of biomedical soft-tissue samples without imaging agent. We first describe the imaging principle of in-plane DEI-CT from the physico-mathematical viewpoints in detail, and investigate what physical quantities are extracted from the reconstructed images. Then, we introduce the imaging system using the synchrotron radiation as a light source, constructed at beamline BL-14B in KEK, Japan. Finally, we demonstrate the advantage of the refraction-based image for non-destructive analysis of biological sample by investigating the image of human breast cancer tumors obtained using the imaging system. Here, the refraction- and the apparent absorption-based images obtained simultaneously by the in-plane DEI-CT are compared. Also, the conventional absorption-based image obtained using micro-computed tomography (μCT) imaging system is compared with them. Thereby, it is shown that the refraction contrast much more sensitively delineates the soft tissues than the absorption contrast. In addition, the radiologic-histologic correlation study not only validates the efficacy for imaging soft tissues, but also produces the potential that the pathological inspection for the breast cancer tumors may be feasible non-destructively.

  8. Dust aerosol emission over the Sahara during summertime from Cloud-Aerosol Lidar with Orthogonal Polarization (CALIOP) observations

    NASA Astrophysics Data System (ADS)

    Todd, Martin C.; Cavazos-Guerra, Carolina

    2016-03-01

    Dust aerosols are an important component of the climate system and a challenge to incorporate into weather and climate models. Information on the location and magnitude of dust emission remains a key information gap to inform model development. Inadequate surface observations ensure that satellite data remain the primary source of this information over extensive and remote desert regions. Here, we develop estimates of the relative magnitude of active dust emission over the Sahara desert based on data from the Cloud-Aerosol Lidar with Orthogonal Polarization (CALIOP). Utilising the unique vertical profile of aerosol characteristics provided by CALIOP our algorithm identifies emission from aerosol extinction and lidar backscatter in the near surface layers. From the long-term CALIOP archive of day and night-time orbits over 2006-13 we construct coarse resolution maps of a new dust emission index (DEI) for the Sahara desert during the peak summer dust season (June to September). The spatial structure of DEI indicates highest emission over a broad zone focused on the border regions of Southern Algeria, Northern Mali and northwest Niger, displaced substantially (∼7°) to the east of the mean maximum in satellite-derived aerosol optical depth. In this region night-time emission exceeds that during the day. The DEI maps substantially corroborate recently derived dust source frequency count maps based on back-tracking plumes in high temporal resolution SEVIRI imagery. As such, a convergence of evidence from multiple satellite data sources using independent methods provides an increasingly robust picture of Saharan dust emission sources. Various caveats are considered. As such, quantitative estimates of dust emission may require a synergistic combined multi-sensor analysis.

  9. Laparoscopic intra-operative ultrasound in liver and pancreas resection: Analysis of 93 cases.

    PubMed

    Piccolboni, D; Ciccone, F; Settembre, A; Corcione, F

    2010-03-01

    Sommario INTRODUZIONE: L’ispezione laparoscopica in chirurgia del pancreas o del fegato è un approccio ampiamente utilizzato. L’aggiunta dell’ecografia intra-operatoria alla laparoscopia ha di recente ulteriormente migliorato la valutazione chirurgica. Lo scopo di questo studio è stato di valutare l’impatto dell’ecografia intra-operatoria open (IOUS) o laparoscopica (LIOUS) in chirurgia del fegato e del pancreas. MATERIALI E METODI: Negli anni 2005–2008, 45 pazienti, di età 42–75 anni, sono stati selezionati per chirurgia epatica resettiva e 48 pazienti, di età 14–72 anni, per resezione parziale del pancreas. L’ecografia intra-operatoria è stata effettuata per mezzo di un apparecchio Aloka SSD-550 (Aloka, Tokyo, Giappone), con sonda lineare laparoscopica a punta flessibile e sonda elettronica lineare a T. RISULTATI: Tra i pazienti epatici, la LIOUS ha evitato inutili laparotomie in sei pazienti (13,3%) ed, insieme alla IOUS, ha consentito di trovare noduli non diagnosticati ed ha cambiato la strategia chirurgica in cinque pazienti (11,1%). Nel gruppo pancreas, la LIOUS ha escluso 7 pazienti (14,4%) dalla chirurgia radicale, per infiltrazione della vena mesenterica, coinvolgimento dei linfonodi celici o para-aortici, micro-metastasi epatiche e peritoneali. In 11 lesioni benigne, ha consentito la definizione dei rapporti con il dotto di Wirsung ed i vasi splenici, in 6 ha guidato l’aspirazione di liquido per analisi chimiche e citologiche. CONCLUSIONI: Nella nostra esperienza la LIOUS e la IOUS hanno avuto la massima importanza sia nella selezione dei pazienti per la chirurgia resettiva e nel pianificare l’approccio chirurgico, influenzando la strategia chirurgica in 11 pazienti epatici (24,4%) e 13 pazienti pancreatici (27%).

  10. Informatics in radiology: dual-energy electronic cleansing for fecal-tagging CT colonography.

    PubMed

    Cai, Wenli; Kim, Se Hyung; Lee, June-Goo; Yoshida, Hiroyuki

    2013-05-01

    Electronic cleansing (EC) is an emerging technique for the removal of tagged fecal materials at fecal-tagging computed tomographic (CT) colonography. However, existing EC methods may generate various types of artifacts that severely impair the quality of the cleansed CT colonographic images. Dual-energy fecal-tagging CT colonography is regarded as a next-generation imaging modality. EC that makes use of dual-energy fecal-tagging CT colonographic images promises to be effective in reducing cleansing artifacts by means of applying the material decomposition capability of dual-energy CT. The dual-energy index (DEI), which is calculated from the relative change in the attenuation values of a material at two different photon energies, is a reliable and effective indicator for differentiating tagged fecal materials from various types of tissues on fecal-tagging CT colonographic images. A DEI-based dual-energy EC scheme uses the DEI to help differentiate the colonic lumen-including the luminal air, tagged fecal materials, and air-tagging mixture-from the colonic soft-tissue structures, and then segments the entire colonic lumen for cleansing of the tagged fecal materials. As a result, dual-energy EC can help identify partial-volume effects in the air-tagging mixture and inhomogeneous tagging in residual fecal materials, the major causes of EC artifacts. This technique has the potential to significantly improve the quality of EC and promises to provide images of a cleansed colon that are free of the artifacts commonly observed with conventional single-energy EC methods.

  11. Informatics in Radiology: Dual-Energy Electronic Cleansing for Fecal-Tagging CT Colonography

    PubMed Central

    Kim, Se Hyung; Lee, June-Goo; Yoshida, Hiroyuki

    2013-01-01

    Electronic cleansing (EC) is an emerging technique for the removal of tagged fecal materials at fecal-tagging computed tomographic (CT) colonography. However, existing EC methods may generate various types of artifacts that severely impair the quality of the cleansed CT colonographic images. Dual-energy fecal-tagging CT colonography is regarded as a next-generation imaging modality. EC that makes use of dual-energy fecal-tagging CT colonographic images promises to be effective in reducing cleansing artifacts by means of applying the material decomposition capability of dual-energy CT. The dual-energy index (DEI), which is calculated from the relative change in the attenuation values of a material at two different photon energies, is a reliable and effective indicator for differentiating tagged fecal materials from various types of tissues on fecal-tagging CT colonographic images. A DEI-based dual-energy EC scheme uses the DEI to help differentiate the colonic lumen—including the luminal air, tagged fecal materials, and air-tagging mixture—from the colonic soft-tissue structures, and then segments the entire colonic lumen for cleansing of the tagged fecal materials. As a result, dual-energy EC can help identify partial-volume effects in the air-tagging mixture and inhomogeneous tagging in residual fecal materials, the major causes of EC artifacts. This technique has the potential to significantly improve the quality of EC and promises to provide images of a cleansed colon that are free of the artifacts commonly observed with conventional single-energy EC methods. © RSNA, 2013 PMID:23479680

  12. Development of an x-ray prism for analyzer based imaging systems

    SciTech Connect

    Bewer, Brian; Chapman, Dean

    2010-08-15

    Analyzer crystal based imaging techniques such as diffraction enhanced imaging (DEI) and multiple imaging radiography (MIR) utilize the Bragg peak of perfect crystal diffraction to convert angular changes into intensity changes. These x-ray techniques extend the capability of conventional radiography, which derives image contrast from absorption, by providing large intensity changes for small angle changes introduced from the x-ray beam traversing the sample. Objects that have very little absorption contrast may have considerable refraction and ultrasmall angle x-ray scattering contrast improving visualization and extending the utility of x-ray imaging. To improve on the current DEI technique an x-ray prism (XRP) was designed and included in the imaging system. The XRP allows the analyzer crystal to be aligned anywhere on the rocking curve without physically moving the analyzer from the Bragg angle. By using the XRP to set the rocking curve alignment rather than moving the analyzer crystal physically the needed angle sensitivity is changed from submicroradians for direct mechanical movement of the analyzer crystal to tens of milliradians for movement of the XRP angle. However, this improvement in angle positioning comes at the cost of absorption loss in the XRP and depends on the x-ray energy. In addition to using an XRP for crystal alignment it has the potential for scanning quickly through the entire rocking curve. This has the benefit of collecting all the required data for image reconstruction in a single measurement thereby removing some problems with motion artifacts which remain a concern in current DEI/MIR systems especially for living animals.

  13. Evaluating Safeguards Benefits of Process Monitoring as compared with Nuclear Material Accountancy

    SciTech Connect

    Humberto Garcia; Wen-Chiao Lin; Reed Carlson

    2014-07-01

    This paper illustrates potential safeguards benefits that process monitoring (PM) may have as a diversion deterrent and as a complementary safeguards measure to nuclear material accountancy (NMA). This benefit is illustrated by quantifying the standard deviation associated with detecting a considered material diversion scenario using either an NMA-based method or a PM-based approach. To illustrate the benefits of PM for effective safeguards, we consider a reprocessing facility. We assume that the diversion of interest for detection manifests itself as a loss of Pu caused by abnormally operating a dissolver for an extended period to accomplish protracted diversion (or misdirection) of Pu to a retained (unconditioned) waste stream. For detecting the occurrence of this diversion (which involves anomalous operation of the dissolver), we consider two different data evaluation and integration (DEI) approaches, one based on NMA and the other based on PM. The approach based on PM does not directly do mass balance calculations, but rather monitors for the possible occurrence of anomaly patterns related to potential loss of nuclear material. It is thus assumed that the loss of a given mass amount of nuclear material can be directly associated with the execution of proliferation-driven activities that trigger the occurrence of an anomaly pattern consisting of series of events or signatures occurring at different unit operations and time instances. By effectively assessing these events over time and space, the PM-based DEI approach tries to infer whether this specific pattern of events has occurred and how many times within a given time period. To evaluate the goodness of PM, the 3 Sigma of the estimated mass loss is computed under both DEI approaches as function of the number of input batches processed. Simulation results are discussed.

  14. The experience of educational quality in undergraduate nursing students: a phenomenological study.

    PubMed

    Macale, Loreana; Vellone, Ercole; Scialò, Gennaro; Iossa, Mauro; Cristofori, Elena; Alvaro, Rosaria

    2016-01-01

    Scopo. La valutazione della formazione accademica è diventata fondamentale nell'Unione Europea da quando il Processo di Bologna ha incoraggiato tutte le università europee a raggiungere elevati standard di qualità nella formazione. Anche se diversi studi sono stati condotti sulla qualità della formazione negli studenti di infermieristica, pochi hanno esplorato questa tematica dalla prospettiva degli studenti. Lo scopo di questo studio è stato di descrivere l'esperienza della qualità formativa negli studenti del corso di laurea in infermieristica. Metodo. E’ stato utilizzato il metodo fenomenologico per studiare 55 studenti (età media 24 anni; 73% donne) che frequentavano il corso di laurea in infermieristica in tre università del centro Italia. Risultati. Dall'analisi fenomenologica sono emersi i seguenti cinque temi: 1) Qualità dei docenti: capacità di insegnamento, preparazione, sensibilità per gli studenti, autodisciplina; 2) Integrazione teoria-pratica e comunicazione tra l'insegnamento e l'area clinica; 3) gestione generale e organizzazione del corso; 4) la qualità delle infrastrutture: biblioteche, aule, tecnologie dell'informazione, servizi, amministrazione, comunicazione; e 5) tutorato clinico: umanità, relazioni e capacità del tutor clinico di guidare e supportare lo studente. Conclusione. I risultati di questo studio forniscono una comprensione nuova e più approfondita sul significato della qualità della formazione negli studenti di infermieristica. Gli studenti ritenevano che la qualità della formazione consistesse nella sensibilità dei docenti verso i loro problemi e nell’umanità, capacità interpersonali, guida e supporto dei tutor cli.

  15. Coyote Springs Cogeneration Project, Morrow County, Oregon: Draft Environmental Impact Statement.

    SciTech Connect

    United States. Bonneville Power Administration.

    1994-01-01

    BPA is considering whether to transfer (wheel) electrical power from a proposed privately-owned, combustion-turbine electrical generation plant in Oregon. The plant would be fired by natural gas and would use combined-cycle technology to generate up to 440 average megawatts (aMW) of energy. The plant would be developed, owned, and operated by Portland General Electric Company (PGE). The project would be built in eastern Oregon, just east of the City of Boardman in Morrow County. The proposed plant would be built on a site within the Port of Morrow Industrial Park. The proposed use for the site is consistent with the County land use plan. Building the transmission line needed to interconnect the power plant to BPA`s transmission system would require a variance from Morrow County. BPA would transfer power from the plant to its McNary-Slatt 500-kV transmission line. PGE would pay BPA for wheeling services. Key environmental concerns identified in the scoping process and evaluated in the draft Environmental Impact Statement (DEIS) include these potential impacts: (1) air quality impacts, such as emissions and their contributions to the {open_quotes}greenhouse{close_quotes} effect; (2) health and safety impacts, such as effects of electric and magnetic fields, (3) noise impacts, (4) farmland impacts, (5) water vapor impacts to transportation, (6) economic development and employment impacts, (7) visual impacts, (8) consistency with local comprehensive plans, and (9) water quality and supply impacts, such as the amount of wastewater discharged, and the source and amount of water required to operate the plant. These and other issues are discussed in the DEIS. The proposed project includes features designed to reduce environmental impacts. Based on studies completed for the DEIS, adverse environmental impacts associated with the proposed project were identified, and no evidence emerged to suggest that the proposed action is controversial.

  16. The prognostic value of sentinel lymph node micrometastases in patients with invasive breast carcinoma.

    PubMed

    Cipolla, Calogero; Graceffa, Giuseppa; La Mendola, Roberta; Fricano, Salvatore; Fricano, Martina; Vieni, Salvatore

    2015-01-01

    Il significato prognostico delle micrometastasi nel linfonodo sentinella nelle pazienti affette da carcinoma della mammella è ancora ampiamente dibattuto. Anche se, in assenza di univoche linee guida, nella pratica clinica la linfadenectomia ascellare in queste pazienti non viene più eseguita di routine. Abbiamo condotto uno studio retrospettivo su 746 patienti affette da carcinoma invasivo della mammella con linfonodi ascellari negativi, sottoposte a chirurgia conservativa o a mastectomia totale con biopsia del linfonodo sentinella. Le pazienti in cui è stata diagnostica la presenza di micrometastasi del linfonodo sentinella sono state considerate in due diversi gruppi. In un primo gruppo, trattato con linfadenectomia ascellare totale è stata valutata l’incidenza di metastasi a carico dei rimanenti linfonodi ascellari. Un secondo gruppo non ha ricevuto alcun trattamento aggiuntivo dell’ascella e le pazienti sono state seguite con controlli periodici clinico strumentali. In entrambi i gruppi è stata valutata l’incidenza di eventuali recidive ascellari. All’esame istologico estemporaneo ed al successivo esame istologico definitivo del linfonodo sentinella, in 51 pazienti (6,83%) sono state evidenziate micrometastasi, in 8 pazienti (1,07%) erano presenti cellule tumorali isolate. Quindici di queste pazienti sono state sottoposte a linfadenectomia ascellare totale. Solo in 2 casi (13,33%) sono state ritrovate metastasi a carico dei rimanenti linfonodi ascellari. Quarantaquattro pazienti non hanno ricevuto alcun trattamento aggiuntivo dell’ascella. In queste pazienti nessuna recidiva ascellare è stata registrata durante un follow-up medio di 65,3±9,65 mesi (range 42-78 mesi). Sulla base dei risultati ottenuti in questo studio ed in linea con alcuni recenti trials randomizzati si ci sentiamo di concludere che la linfadenectomia ascellare può essere evitata nei casi con micrometastasi nel linfonodo sentinella. Una sua eventuale indicazione può essere

  17. AFHRL Annual Report FY 80.

    DTIC Science & Technology

    1980-01-01

    pecrfrmarice erihiarncemnrt. but flight simulation withn a hr lahorator\\ %as initegrati’d the expansion oif’ thet art’a of’ comncern and its integration into...Ilifijzaitioni: \\sallee ill iiask-eiewiteh ie’,ir’c’it Kalmian~ Fite lle teeII, r predicting .iiiited retenione lil.S iliflacit rinstrucetioinal .5dilt-elsgie...Simulator for Air-to-Air Combat Target Training (\\Sri’). Trhe effort requnired the( selection of’ Enhanrcement Study flight test tasks. de-i Oit ioni of thle

  18. Non-Poisson Processes: Regression to Equilibrium Versus Equilibrium Correlation Functions

    DTIC Science & Technology

    2007-11-02

    76203-1427, USA cDipartimento di Fisica dell’Università di Pisa and INFM, Via Buonarroti 2, 56127 Pisa, Italy dIstituto dei Processi Chimico Fisici del...CNR, Area della Ricerca di Pisa, Via G. Moruzzi 1, 56124 Pisa, Italy eDipartimento di Fisica and INFM, Center for Statistical Mechanics and Complexity...dichotomous fluctuations that generate super-diffusion. We adopt the Liouville perspective and with it a quantum-like approach based on splitting the density

  19. Research in Network Management Techniques for Tactical Data Communications Network.

    DTIC Science & Technology

    1982-09-01

    53 5 4 and from (7) 2 Micronode eurmpcsiron of a Fe - No(e Chon Q(D) = Q((D) C1 Li q.e.d. iD Pi N w dei e g 4? g45 ang, 54 Thus the steady, state...are given by Sd and Gd respectively. 0 The following areas ’are defined (see Figure 2): A1 - Inside the contour D-E-F-C-H-D. A2 - Inside the...for perfect capture. - Area (A3 UA 4 UA 5 ) during {t - 1, t +I) for half amplitude capture. The probability of successful transmission Sd/ Gd , will be

  20. The Electrodynamic, Thermal, and Energetic Character of Intense Sun- Aligned Arcs in the Polar Cap

    DTIC Science & Technology

    1991-02-01

    IoUit y ( diii 15111 ward flow oil tilie dawnit ed (ge 0 (itth arc Iihjijk like !oCaio)1 of’ S1101 I-f~ ersi IC lt J 00 (C hk:iir driven by (fowrrwir...design is based on what we know of their morphology by combining the optical emissions associated with S-A arcs from optical imagery. The essence of...8217:en h% BrcAW ct al. 119741 and /ca lcilojirdfierc cI (it. 1 1977. I IL! t imirit dei- idijxi.] hull the &OLtl Ck)[ rC~ph) lllt ! Ili Ilt I I . _1lt

  1. Three-port colectomy: reduced port laparoscopy for general surgeons. A single center experience.

    PubMed

    Cocorullo, Gianfranco; Tutino, Roberta; Falco, Nicolò; Salamone, Giuseppe; Gulotta, Gaspare

    Le resezioni coliche laparoscopiche sia per patologie benigne che maligne sono state investigate da importanti RCT che ne hanno dimostrato la sovrapponibilità alla tecnica open convenzionale. La laparoscopia con un numero ridotto di trocar ha da quel momento trovato ampio sviluppo nell’ottica di massimizzare i benefici della mini-invasività. Proponiamo un’analisi dei nostri risultati nell’utilizzo della tecnica three-port nella emicolectomia sinistra attraverso un confronto con la classica resezione laparoscopica con quattro/ cinque accessi. Come è noto i laparoceli si sviluppano maggiormente su incisioni mediane mentre non vi è differenza tra lo sviluppo di questi dopo tecnica open o laparoscopica. Nell’ottica della chirurgia a numero ridotto di accessi, la tecnica single-port sembra dare vantaggi di minor traumatismo ma ciò a costo di aumentate difficoltà di esecuzione, aumento dei tempi operatori e dell’utilizzo di strumenti per lo più dedicati, con incisioni ombelicali che possono superare i 5 cm. Le resezioni coliche three port consentono di ridurre il numero di accessi e dunque delle complicanze a questi correlate con l’utilizzo di strumentazione standard e la possibilità di esecuzione su larga scala da parte di ogni chirurgo. L’analisi che abbiamo eseguito ha dimostrato nella nostra serie una riduzione dei tempi operatori nella tecnica three port e ciò può essere dovuto all’inserimento dei trocar addizionali ed al loro controllo ma soprattutto alla possibilità/ necessità del chirurgo esperto di essere meno influenzato da fattori quali una equipe non dedicata. Non sono stati evidenziati vantaggi nella riduzione della degenza operatoria. Il tasso di conversione è stato maggiore nella tecnica a ridotto numero di accessi, questo è possibile sia un bias legato alle conversioni precoci prima del posizionamento di restanti trocar in casi particolarmente complessi. In conclusione, la tecnica three port appare comparabile alla

  2. Analysis of Ejection Seat Stability Using Easy Program. Volume I.

    DTIC Science & Technology

    1980-09-01

    2,4 STROKE, VS, TIME, YRANGE =-.5,.5 PI DEI, VS, TIME, YRANGE = 0,60 DISPLAY2 P1 , CE, VS, TIME, YRANGE = -20,20 P1 , DE2, VS, TIME, YRANGE = -15,15...The TITLE command may be changed before each analysis. Once 54 defined, the title remains in effect until a new title is entered. Exam - ples of these...body (survival kit ) AE Airplane AG Atmospheric properties AM Aeromedical AP Aerodynamic plate AS Seat aerodynamics CE Crewperson CS Airplane control

  3. Naval Research Logistics Quarterly. Volume 23, Number 1

    DTIC Science & Technology

    1976-03-01

    Imm the hr»t »lep i«. le»» than In- IPIHII;’’! I In- plannet nun liaM- the mi »«lie Im each t\\ [><• nt -\\-tcni ealeiton/ed a« iwlul a(Cain*>t hard...KM I Inr tin- »ei-ond ^roup liein|I presented with a inulln rilfrmn prolilrni tin plannet nui-I dei ide the t\\|<»- oj nptimum In desire» Inr example

  4. Theoretical Bases of Polymer Photodegradation and Photooxidation,

    DTIC Science & Technology

    1987-10-15

    UNCLASSIFIED FTD- AD(RS)T-E868-87 F/G 7/6 NL MhEEOEE~~h EhiIIIEEEEEI -M Mi(ROC PY RESOLUtIO(N TEST CHA NA ION- A j ~A M R ~ . DEiC FILE CME ( 1 ) FTD-ID...In addition, when such processes are carried out in an atmosphere of air, numerous carbonyl, carboxyl , hydroxyl etc. groups form along the polymer...photoaging this should be multilateral with consideration of the following basic processes [ 1 -93: ...... 1 . Photochemical reactions of the actual

  5. Environmental Impact Statement. Groom Mountain Range, Lincoln County, Nevada

    DTIC Science & Technology

    1986-06-01

    Rachel into the Nevada Test Site (NTS). The Air Force recommends this as a miti- gation measure to be shared with Lincoln County. A schedule of open...number has been provided so NTS workers can check to determine if the road is open to traffic from the NTS to Rachel . 1.4 ALTERNATIVES Alternatives to...presented in Sections 3.10 and 4.2.10 of the DEIS. 18. "Maintenance, Use and Paving of the Rachel to NTS Road" Maintenance of the 43 mile road from

  6. Perceived quality in Day Surgery Units Proposal of an enquiry postoperative questionnaire.

    PubMed

    Palumbo, Piergaspare; Perotti, Bruno; Amatucci, Chiara; Pangrazi, Maria Pia; Leuzzi, Barbara; Vietri, Francesco; Illuminati, Giulio

    2016-01-01

    La soddisfazione dei pazienti assume particolare importanza nell’attività chirurgica in Day Surgery, al fine di mantenere ed incrementare la domanda di prestazioni da parte dell’utenza ed inoltre di valutare le abilità e le competenze dello staff clinico dedicato. Sono stati valutati i risultati di un questionario somministrato dal 2007 al 2012, divisi in due gruppi, alla dimissione e a 30 giorni dall’intervento. Tali risultati hanno permesso di valutare i principali vantaggi e limiti del questionario in termini di comprensibilità, di corretto timing di somministrazione, e di utilità per lo staff clinico.

  7. Aircraft and satellite thermographic systems for wildfire mapping and assessment

    NASA Technical Reports Server (NTRS)

    Brass, J. A.; Arvesen, J. C.; Ambrosia, V. G.; Riggan, P. J.; Myers, J. S.

    1987-01-01

    Two complementary sensors, the DAEDALUS DEI-1260 Multispectral Scanner aboard the NASA U-2 aircraft and the Advanced Very High Resolution Radiometer aboard National Oceanographic and Atmospheric Administration orbiting satellites were tested for their applicability in monitoring and predicting parameters such as fire location, temperature and rate of spread, soil heating and cooling rates, and plume characteristics and dimensions. In addition, the satellite system was tested for its ability to extend the relationships found between fire characteristics and biospheric consequences to regional and global scales. An overall system design is presented, and special requirements are documented for the application of this system for fire research and management.

  8. Explaining Correlations by Partitions

    NASA Astrophysics Data System (ADS)

    Stergiou, Chrysovalantis

    2015-12-01

    In this paper two accounts of Reichenbachian common cause systems are compared. Examples are provided which show that Hofer-Szabó and Rédei (Int J Theor Phys 43:1819-1826, 2004) account and Hofer-Szabó et al. (The principle of the common cause, 2013) account is compatible, with but not equivalent, to Mazzola's (Found Phys 42:512-523, 2012). Moreover, the difference of the two accounts with respect to their explanatory adequacy is discussed, in the light of Salmon's statistical-relevance approach to statistical explanation.

  9. Staff Movements

    NASA Astrophysics Data System (ADS)

    Huber, M. C. E.

    1986-09-01

    Los astronomos de ESO dedican una considerable parte de su tiempo a la preparacion de solicitudes para tiempo de observacion en La Silla. Sin embargo, debido a la gran demanda par los telescopios, se debe hacer una seleccion, aveces drastica, de los programas de observacion presentados. EI Comite de Programas de Observacion (OPC) tiene como tarea evaluar el merito cientifico de las solicitudes presentadas. Basada en las recomendaciones dei OPC, ESO prepara una Lista de Tiempos de Observacion en la cual distribuye el tiempo disponible en los telescopios a los programas mejor evaluados.

  10. Line x-ray source for diffraction enhanced imaging in clinical and industrial applications

    NASA Astrophysics Data System (ADS)

    Wang, Xiaoqin

    Mammography is one type of imaging modalities that uses a low-dose x-ray or other radiation sources for examination of breasts. It plays a central role in early detection of breast cancers. The material similarity of tumor-cell and health cell, breast implants surgery and other factors, make the breast cancers hard to visualize and detect. Diffraction enhanced imaging (DEI), first proposed and investigated by D. Chapman is a new x-ray radiographic imaging modality using monochromatic x-rays from a synchrotron source, which produced images of thick absorbing objects that are almost completely free of scatter. It shows dramatically improved contrast over standard imaging when applied to the same phantom. The contrast is based not only on attenuation but also on the refraction and diffraction properties of the sample. This imaging method may improve image quality of mammography, other medical applications, industrial radiography for non-destructive testing and x-ray computed tomography. However, the size, and cost, of a synchrotron source limits the application of the new modality to be applicable at clinical levels. This research investigates the feasibility of a designed line x-ray source to produce intensity compatible to synchrotron sources. It is composed of a 2-cm in length tungsten filament, installed on a carbon steel filament cup (backing plate), as the cathode and a stationary oxygen-free copper anode with molybdenum coating on the front surface serves as the target. Characteristic properties of the line x-ray source were computationally studied and the prototype was experimentally investigated. SIMIION code was used to computationally study the electron trajectories emanating from the filament towards the molybdenum target. A Faraday cup on the prototype device, proof-of-principle, was used to measure the distribution of electrons on the target, which compares favorably to computational results. The intensities of characteristic x-ray for molybdenum

  11. Cork Embedded Internal Features and Contrast Mechanisms with Del Using 18, 20, 30, 36 and 40 keV Synchrotron X-rays

    SciTech Connect

    Rao, D.V.; Zhong, Z.; Akatsuka, T.; Yuasa, T.; Hasan, M.Z.; Takeda, T.

    2010-01-01

    Images of the cork used for wine and other bottles are visualized with the use of diffraction-enhanced imaging (DEI) technique. Present experimental studies allowed us to identify the cracks, holes, porosity, and importance of soft-matter (soft-material) and associated biology by visualization of the embedded internal complex features of the biological material such as cork and its microstructure. Highlighted the contrast mechanisms above and below the K-absorption edge of iodine and studied the attenuation through a combination of weakly and strongly attenuating materials.

  12. Diana Reference Manual. Revision 3,

    DTIC Science & Technology

    1983-02-28

    Lterale - yno 2.3 - not of Interest for Diane 10 :.a OEF-10I I USMD....D OP : : x OEP..OP I USMDOP; DEI 3NATOR : :z 10 1 Or; OEPOCCJRRENC :: EP_ID I... Ideferred constant; -deterred constant~declaraton (7.4) DCI pragma; -pregmea lowe as declaration ADA Section 2. 3 Page 34 / teCtIOfl 2 otAIA Rteference...osat -see rationale Section 3.5.2.14 csao fdeerdcosat const-id I X -Srcpoe : ort..positiofl. Ix...commelnfts comments. Ix-sym rep :symbol rep; cosstd

  13. Normative aspects of the human body.

    PubMed

    Siep, Ludwig

    2003-04-01

    In cultural history the human body has been the object of a great variety of opposing valuations, ranging from "imago dei" to "the devil's tool". At present, the body is commonly regarded as a mere means to fulfill the wishes of its "owner". According to these wishes it can be technically improved in an unlimited way. Against this view the text argues for a conception of the human body as a valuable "common heritage". The "normal" human body as the result of natural and cultural history is an essential condition of the modern social and legal order. The consequences of its technical alteration should be the subject of public debates and common decisions.

  14. Differential PIXE for investigating the layer structure of paintings

    NASA Astrophysics Data System (ADS)

    Mandò, P. A.; Fedi, M. E.; Grassi, N.; Migliori, A.

    2005-09-01

    This paper reports an example of how the differential PIXE technique can be successfully applied to the investigation of wood or canvas paintings. The work analysed is a famous wood painting by Leonardo da Vinci, the "Madonna dei fusi" (ex-Reford version, 1501), chosen for a pilot study in a wide international project aimed at analysing Leonardo's works of art by means of non-destructive techniques. While illustrating the results obtained concerning the identification of pigments and the discrimination of the stratigraphy of layers, the merits and limits of differential PIXE in general are pointed out.

  15. A panchromatic view of the evolution of Supermassive Black Holes

    NASA Astrophysics Data System (ADS)

    Lusso, E.; Brusa, M.; Comastri, A.; Vignali, C.; Gilli, R.

    2008-10-01

    Verranno presentati i risultati preliminari di uno studio sistematico delle distribuzioni di energia spettrale (SED) di un campione statisticamente significativo di alcune centinaia di AGN (sia di tipo 1 che di tipo 2) selezionati dalla survey XMM-COSMOS. La vasta mole di dati disponibili sull'intero spettro elettromagnetico permette di calcolare le SED medie per diversi intervalli di redshift e luminosita'. Una stima affidabile della SED e' di fondamentale importanza per il calcolo della luminosita' bolometrica e quindi per lo studio della fisica dei processi di accrescimento su SMBH, per la loro evoluzione con il tempo cosmico.

  16. Obsidians from the Kerkennah Islands (eastern Tunisia) and the PIXE elemental compositions of the Mediterranean peralkaline obsidians

    NASA Astrophysics Data System (ADS)

    Le Bourdonnec, François-Xavier; Poupeau, Gérard; Boussofara, Ridha; Dubernet, Stéphan; Moretto, Philippe; Compin, Matthieu; Mulazzani, Simone

    2015-09-01

    The provenance of 37 obsidians from the Kerkennah Islands (central Mediterranean Sea) was determined by PIXE. It is shown that they came from the two main obsidian sources, Balata dei Turchi and Lago di Venere, of the Pantelleria Island. A comparison of the PIXE elemental composition of geological vs. archaeological obsidians of central and western Mediterranean shows that their sources present elemental compositions homogeneous enough to make possible sourcing studies. However, a comparison between the distributions of geological and archaeological obsidians chemistry shows that the PIXE source qualifications do not cover yet the whole of their internal variations.

  17. Teorie Dinamiche Dell' Ala

    NASA Astrophysics Data System (ADS)

    Finzi, Bruno

    Non è facile rendersi conto del birzarro comportamento dei fluidi poco viscosi, quali l'aria e l'acqua, deducendolo logicamente e matematicamente, come è nello spirito della fisica matematica, da poche proposizioni generali tratte dall'esperienza. Ciò perchè le schematizzazioni più semplici suggerite dal senso comune, in virtù del quale piccole cause non possono produrre che piccoli effetti, e facenti capo a campi cinetici ovunque regolari, portano a risultati paradossali sconcertanti, quali il paradosso di d'Alembert.

  18. Late surgical complications of subtotal colectomy with antiperistaltic caeco-rectal anastomosis for slow transit constipation A critical analysis.

    PubMed

    Marchesi, Federico; Rapacchi, Chiara; Cecchini, Stefano; Sarli, Leopoldo; Tartamella, Francesco; Roncoroni, Luigi

    2016-01-01

    La stipsi grave da rallentato transito è stata negli ultimi anni definitivamente riconosciuta come una condizione potenzialmente chirurgica, e nuove varianti tecniche sono state proposte in alternativa alla colectomia totale con ileo-retto anastomosi con l’obiettivo di minimizzare il rapporto rischi-benefici per il paziente. In quest’ottica la colectomia subtotale con anastomosi ceco-rettale (SCCRA) rappresenta nella nostra esperienza una valida alternativa, riducendo, a parità di efficacia, l’incontinenza e l’urgency postoperatoria, grazie alla preservazione della valvola ileo-cecale e del reservoir cecale. Tuttavia, a fronte di una buona percentuale di successi, legati soprattutto al miglioramento della selezione dei pazienti, la chirurgia della stipsi da rallentato transito presenta tuttora un non trascurabile numero di insuccessi e di complicanze tardive, spesso imprevedibili, e correlate alle varianti tecniche adottate. Nello specifico caso della SCCRA, la preservazione di un segmento colico verosimilmente malfunzionante (il ceco) è stata imputata come possibile causa di recidiva di stipsi cosiccome origine di complicanze chirurgiche tardive (distensione cecale, volvolo). L’obiettivo di questo studio è di analizzare in maniera critica le complicanze tardive di SCCRA, esaminando i rischi specifici della procedura per identificare possibili misure di prevenzione. A tal fine sono stati valutati i dati di 43 pazienti aderenti al follow-up sottoposti a SCCRA presso il nostro Istituto. Sono stati inclusi i pazienti sottoposti a re-intervento per complicanza tardiva chiaramente correlata a SCCRA presso il nostro centro. Sono state identificate 3 complicanze tardive (7%): una distensione cecale, un volvolo ileo-cecale, un volvolo ileale. Tutti i pazienti sono stati trattati chirurgicamente con successo. Solo nel primo caso è stata identificata una evidente condizione predisponente: la presenza di una defecazione ostruita non risolta associata ad un

  19. Statistical analysis of Thematic Mapper Simulator data for the geobotanical discrimination of rock types in southwest Oregon

    NASA Technical Reports Server (NTRS)

    Morrissey, L. A.; Weinstock, K. J.; Mouat, D. A.; Card, D. H.

    1984-01-01

    An evaluation of Thematic Mapper Simulator (TMS) data for the geobotanical discrimination of rock types based on vegetative cover characteristics is addressed in this research. A methodology for accomplishing this evaluation utilizing univariate and multivariate techniques is presented. TMS data acquired with a Daedalus DEI-1260 multispectral scanner were integrated with vegetation and geologic information for subsequent statistical analyses, which included a chi-square test, an analysis of variance, stepwise discriminant analysis, and Duncan's multiple range test. Results indicate that ultramafic rock types are spectrally separable from nonultramafics based on vegetative cover through the use of statistical analyses.

  20. Diffraction enhanced x-ray imaging

    SciTech Connect

    Thomlinson, W.; Zhong, Z.; Chapman, D.; Johnston, R.E.; Sayers, D.

    1997-09-01

    Diffraction enhanced imaging (DEI) is a new x-ray radiographic imaging modality using synchrotron x-rays which produces images of thick absorbing objects that are almost completely free of scatter. They show dramatically improved contrast over standard imaging applied to the same phantoms. The contrast is based not only on attenuation but also the refraction and diffraction properties of the sample. The diffraction component and the apparent absorption component (absorption plus extinction contrast) can each be determined independently. This imaging method may improve the image quality for medical applications such as mammography.

  1. [β-hydroxy-β-methylbutyrate as a dietary supplement (II): cell and molecular mechanism of action].

    PubMed

    Manjarrez-Montes-de-Oca, Rafael; Torres-Vaca, Mateo; González-Gallego, Javier; Alvear-Ordenes, Ildefonso

    2014-11-27

    Introducción: En los últimos años el -hidroxi--metilbutirato (HMB) ha sido foco de diversas investigaciones que le atribuyen un efecto sobre la disminución de la proteólisis muscular y un incremento de la masa muscular. Por tanto, se han realizado estudios centrados en los mecanismos celulares y moleculares responsables de dichos efectos. Objetivos: Los objetivos de la presente revisión son: conocer el metabolismo del HMB, así como su absorción y excreción; estudiar la posible toxicidad del HMB; e identificar los mecanismos celulares y moleculares de acción del HMB cuando se utiliza como suplemento nutricional. Métodos: Se utilizaron las bases de datos Web of Science, Pubmed y SportDiscus para realizar la búsqueda de artículos. Los resultados se dividieron en dos partes; en este artículo se presentan los resultados referentes a los mecanismos de acción del HMB. Resultados: No existen suficientes datos que apoyen que la ingesta de HMB incremente la síntesis de colesterol en el músculo. Es posible que existan efectos positivos en el metabolismo muscular a través de la vía mTOR y del sistema ubiquitin-proteasoma, aunque no se conoce su mecanismo de acción. Probablemente, el HMB eleva los niveles sanguíneos de hidroxibutirato y esto podría explicar sus principales efectos sobre la disminución de la proteólisis muscular. Conclusiones: De acuerdo a nuestros resultados, la posibilidad de justificar la acción del HMB a través de la vía del beta-hidroxibutirato abre una interesante línea de investigación para futuros estudios.

  2. [Metabolic myopathies].

    PubMed

    Papazian, Óscar; Rivas-Chacón, Rafael

    2013-09-06

    Objetivo. Revisar las miopatias metabolicas manifestadas solamente por crisis de mialgias, calambres y rigidez musculares con dificultad para contraer los musculos afectados y el examen neurologico normal entre las crisis en niños y adolescentes. Desarrollo. Estas miopatias metabolicas se deben a deficits enzimaticos heredados en forma autosomica recesiva del metabolismo de los carbohidratos y lipidos. El resultado final es una reduccion del trifosfato de adenosina principalmente a traves de la fosforilacion oxidativa mitocondrial con disminucion de la energia disponible para la contraccion muscular. Las secundarias a trastornos del metabolismo de los carbohidratos se producen por ejercicios de alta intensidad y breves (< 10 min) y las secundarias a trastornos de los lipidos, por ejercicios de baja intensidad y prolongados (> 10 min). Los deficits enzimaticos en el primer grupo son de miofosforilasa (glucogenosis V), fosfofructocinasa muscular (glucogenosis VII), fosfoglicerato mutasa 1 (glucogenosis X) y beta enolasa (glucogenosis XIII), y en el segundo, de carnitina palmitol transferasa tipo II y de acil-CoA deshidrogenasa de cadena muy larga. Conclusiones. Las caracteristicas diferenciales de los pacientes en cada grupo y dentro de cada grupo permitiran el diagnostico clinico presuntivo inicial en la mayoria y solicitar solamente los examenes necesarios para corroborar el diagnostico. El tratamiento de las crisis consiste en hidratacion, glucosa y alcalinizacion de la orina. Las medidas preventivas son evitar el tipo de ejercicio que induce las crisis y el ayuno. No existe cura o tratamiento especifico. El pronostico es bueno con la excepcion de casos raros de insuficiencia renal aguda debido a la elevacion sanguinea de la mioglobina producto de una rabdomiolisis grave.

  3. State of malnutrition in cuban hospitals; a needed update.

    PubMed

    Santana Porbén, Sergio

    2015-05-01

    Justificación: El Estudio Cubano de Desnutricion Hospitalaria, conducido en el bienio 1999 – 2001 con 1,905 pacientes atendidos en 12 hospitales de 6 provincias del pais, revelo una tasa de desnutricion hospitalaria del 41.2%. Transcurrida una decada de aquella indagacion, se impone la actualizacion de este estimado. Objetivo: Actualizar el estado de la desnutricion hospitalaria en Cuba. Material y método: La presencia de desnutricion en 1,664 pacientes ingresados en 12 hospitales de 8 provincias del pais entre Marzo del 2012 y Marzo del 2014 se documento mediante la Encuesta Subjetiva Global (ESG). El estado de los procesos hospitalarios de cuidados alimentarios y nutricionales se evaluo con la Encuesta de Nutricion Hospitalaria (ENH). Resultados: La tasa corriente de desnutricion hospitalaria fue del 36.9% (Δ = +4.3%; p < 0.05). Las tasas de completamiento de los ejercicios hospitalarios de evaluacion nutricional y de uso de terapias de replecion nutricional fueron superiores. Conclusiones: Transcurridos 10 anos de la primera edicion del Estudio ELAN CUBA, se aprecian modestos avances en la identificacion y el tratamiento de la desnutricion en los hospitales en Cuba. Se percibe que la formacion e insercion de nutricionistas verticalizados en la actuacion hospitalaria haya contribuido al cambio observado. Asimismo, la actividad de la Sociedad Cubana de Nutricion Clinica y Metabolismo en el avance de las disciplinas de la terapia nutricional, la nutricion artificial y el metabolismo puede haber servido para un mejor reconocimiento del problema de salud representado por la desnutricion hospitalaria.

  4. Proposed Columbia Wind Farm No. 1 : Draft Environmental Impact Statement, Joint NEPA/SEPA.

    SciTech Connect

    United States. Bonneville Power Administration; Klickitat County

    1995-03-01

    This Draft Environmental Impact Statement (DEIS) addresses the Columbia Wind Farm {number_sign}1 (Project) proposal for construction and operation of a 25 megawatt (MW) wind power project in the Columbia Hills area southeast of Goldendale in Klickitat County, Washington. The Project would be constructed on private land by Conservation and Renewable Energy System (CARES) (the Applicant). An Environmental Impact Statement is required under both NEPA and SEPA guidelines and is issued under Section 102 (2) (C) of the National Environmental Policy Act (NEPA) at 42 U.S.C. 4321 et seq and under the Washington State Environmental Policy Act (SEPA) as provided by RCW 43.21C.030 (2) (c). Bonneville Power Administration is the NEPA lead agency; Klickitat County is the nominal SEPA lead agency and CARES is the SEPA co-lead agency for this DEIS. The Project site is approximately 395 hectares (975 acres) in size. The Proposed Action would include approximately 91 model AWT-26 wind turbines. Under the No Action Alternative, the Project would not be constructed and existing grazing and agricultural activities on the site would continue.

  5. Visualization of microvascular proliferation as a tumor infiltration structure in rat glioma specimens using the diffraction-enhanced imaging in-plane CT technique

    NASA Astrophysics Data System (ADS)

    Seo, Seung-Jun; Sunaguchi, Naoki; Yuasa, Tetsuya; Huo, Qingkai; Ando, Masami; Choi, Gi-Hwan; Kim, Hong-Tae; Kim, Ki-Hong; Jeong, Eun-Ju; Chang, Won-Seok; Kim, Jong-Ki

    2012-03-01

    In order to study potent microenvironments of malignant gliomas with a high- resolution x-ray imaging technique, an injection orthotopic glioma model was made using the Sprague-Dawley rat. Total brain tissue, taken out as an ex vivo model, was examined with diffraction-enhanced imaging (DEI) computed tomography (CT) acquired with a 35 keV monochromatic x-ray. In the convolution-reconstructed 2D/3D images with a spatial resolution of 12.5 × 12.5 × 25 µm, distinction among necrosis, typical ring-shaped viable tumors, edemas and healthy tissues was clearly observed near the frontal lobe in front of the rat's caudate nucleus. Multiple microvascular proliferations (MVPs) were observed surrounding peritumoral edemas as a tumor infiltration structure. Typical dimensions of tubular MVPs were 130 (diameter) ×250 (length) µm with a partial sprout structure revealed in the 3D reconstructed image. Hyperplasia of cells around vessel walls was revealed with tumor cell infiltration along the perivascular space in microscopic observations of mild MVP during histological analysis. In conclusion, DEI-CT is capable of imaging potent tumor-infiltrating MVP structures surrounding high-grade gliomas.

  6. [Knowledge and common sense of nurses on the health's inequities: an exploratory study.

    PubMed

    Cotichelli, Giordano; Di Meo, Giorgia; Giampieri, Paolo

    2016-01-01

    Introduzione. I dati statistici per il 2015 parlano di un peggioramento generale delle condizioni di vita e di salute della popolazione in Italia. Le possibili ricadute chiamano l’infermiere ad un coinvolgimento in tema di disuguaglianze nella salute. Lo studio è stato realizzato con lo scopo di valutare quanto gli infermieri conoscono e percepiscono la correlazione fra le condizioni di salute della popolazione e le iniquità di sistema. Metodo. E’ stato condotto uno studio esplorativo attraverso un aggiornamento bibliografico rispetto a precedenti lavori e la somministrazione di questionari a campioni di convenienza di professionisti e studenti di infermieristica e valutazione dei risultati secondo la prospettiva del mixed method. Risultati. La bibliografia infermieristica presente sul piano quantitativo è molto limitata. Il questionario fornisce risposte utili alla valutazione della percezione delle disuguaglianze nella salute in termini di equità orizzontale e verticale. Conclusioni. La conoscenza delle disuguaglianze nella salute non può essere al margine dei lavori scientifici e della stessa letteratura professionale. E’ necessario ridurre il divario fra gli aspetti valoriali propri della professione, che riverberano nella percezione delle iniquità esistenti, e l’assunzione piena del sapere correlato ai determinanti socio-economici della salute e della malattia.

  7. Intermittent pneumatic compression in laparoscopic surgery for prevention of deep vein thrombosis and cellular damage from iatrogenic compartment syndrome.

    PubMed

    Sederino, Maria Grazia; Casamassima, Giulia; Laforgia, Rita; Balducci, Giovanni; Carbotta, Giuseppe; Tromba, Antonella

    In chirurgia laparoscopica l’induzione del pneumoperitoneo (PNP) realizza una sindrome compartimentale iatrogena con ripercussioni sul circolo venoso profondo degli arti inferiori. In questo studio abbiamo voluto valutare l’incidenza di Trombosi Venosa Profonda (TVP) postoperatoria e del danno cellulare da sindrome compartimentale iatrogena analizzando due gruppi di pazienti, ad uno dei quali è stato applicato un dispositivo Sequential Compression Device (SCD). I pazienti selezionati sono stati suddivisi in due gruppi e sono stati sottoposti a chirurgia laparoscopica con durata non inferiore a 90’. È stato rilevato con metodo ECOCOLOR-DOPPLER il flusso venoso degli arti inferiori e soltanto ad uno dei due gruppi è stato applicato un dispositivo SCD. Da novembre 2006 a ottobre 2007 sono stati valutati 35 pz, 21 pz con dispositivo SCD e 14 pz utilizzati come gruppo controllo, con follow-up a 7 gg, 14 gg, 30 gg, a 3 e 5 anni. L’utilizzo di un dispositivo SCD applicato agli arti inferiori consente un aumento del ritorno venoso dagli arti inferiori diminuendone il rischio di TVP.

  8. Refractive-index based tomosynthesis using dark-field imaging optics

    NASA Astrophysics Data System (ADS)

    Sunaguchi, N.; Yuasa, T.; Ichihara, S.; Huo, Q.; Sakai, M.; Wu, Y.; Shimao, D.; Ando, M.

    2013-03-01

    Tomosynthesis (TS) is a pseudo-3-dimensional image reconstruction method to recover depth-resolved information using restricted number of projections. In this research, refraction index based TS imaging using dark-field imaging (DFI) optics is proposed and biomedical soft tissues were imaged in low dose exposure. By a single exposure of an object, two projected images are obtained from a Laue-case analyzer of DFI. Calculating the both images refraction component is deduced, while two exposures are needed in DEI (diffraction enhanced imaging). Thus the measurement time and the radiation dose in DFI are half of DEI. In addition, the proposed reconstruction algorithm, derived from the quantitative relationship in measurement process, allows high contrast tomographic imaging in spite of one order smaller number of projections for CT (computed tomography). To demonstrate the proposed imaging protocol efficacy, an ex-vivo excised tissue of human lung were imaged using a system constructed at the vertical wiggler beamline at PF-BL14C at KEK. TS image is successfully delineated high quality soft tissue structures comparable to CT.

  9. Transanal endoscopic video-assisted (TEVA) resection of early rectal lesions using a SILS port A single center experience.

    PubMed

    Cipolla, Calogero; Ferro, Giuseppina; Graceffa, Giuseppa; Morini, Lorenzo; Guercio, Giuseppina; Vieni, Salvatore; Pantuso, Gianni

    2016-01-01

    L’escissione chirurgica endoscopica transanale video-assistita (TEVA) mediante SILSTM– Port (Single Incision Laparoscopic Surgery) si è affermata come una tecnica valida per la rimozione completa di lesioni benigne del retto non trattabili endoscopicamente e per le neoplasie maligne del retto in fase precoce. La TEVA rappresenta una valida alternativa alla escissione microchirurgica transanale (TEM), alla chirurgia transanale convenzionale ed alla resezione transaddominale. Nella nostra Unità Operativa sono state effettuate con successo 8 resezioni di voluminosi adenomi del retto impiegando la tecnica TEVA con con il SILSTM–Port. L’età media dei pazienti è stata di 51,1 anni, il BMI medio è stato di 23. Non sono state registrate complicanze post-operatorie né conversioni verso interventi resettivi maggiori per via trans-addominale. Il decorso post-operatorio dei pazienti è stato regolare. Il tempo medio di ospedalizzazione è stato di 3 giorni. I risultati della nostra esperienza, sia pure poco numerosa, in ci consentono di valutare la tecnica TEVA con SILSTM– Port più semplice da realizzare rispetto alla TEM. La metodica infatti non richiede lunghi periodi di apprendimento né l’impiego di materiale costoso come quello impiegato nella TEM.

  10. Transanal endoscopic video-assisted (TEVA) resection of early rectal lesions using a SILS port A single center experience.

    PubMed

    Cipolla, Calogero; Ferro, Giuseppina; Graceffa, Giuseppa; Morini, Lorenzo; Guercio, Giuseppina; Vieni, Salvatore; Pantuso, Gianni

    2015-11-30

    L’escissione chirurgica endoscopica transanale video-assistita (TEVA) mediante SILSTM– Port (Single Incision Laparoscopic Surgery) si è affermata come una tecnica valida per la rimozione completa di lesioni benigne del retto non trattabili endoscopicamente e per le neoplasie maligne del retto in fase precoce. La TEVA rappresenta una valida alternativa alla escissione microchirurgica transanale (TEM), alla chirurgia transanale convenzionale ed alla resezione transaddominale. Nella nostra Unità Operativa sono state effettuate con successo 8 resezioni di voluminosi adenomi del retto impiegando la tecnica TEVA con con il SILSTM–Port. L’età media dei pazienti è stata di 51,1 anni, il BMI medio è stato di 23. Non sono state registrate complicanze post-operatorie né conversioni verso interventi resettivi maggiori per via trans-addominale. Il decorso post-operatorio dei pazienti è stato regolare. Il tempo medio di ospedalizzazione è stato di 3 giorni. I risultati della nostra esperienza, sia pure poco numerosa, in ci consentono di valutare la tecnica TEVA con SILSTM– Port più semplice da realizzare rispetto alla TEM. La metodica infatti non richiede lunghi periodi di apprendimento né l’impiego di materiale costoso come quello impiegato nella TEM.

  11. New "all-in-one" device for mesh plug hernioplasty: the Trabucco repair.

    PubMed

    Gossetti, Francesco; Massa, Salvatore; Abbonante, Francesco; Calabria, Michele; Ceci, Francesca; Viarengo, Maria Antonietta; Manzi, Emy; D'Amore, Linda; Negro, Paolo

    2015-01-01

    Sebbene la tecnica Mesh Plug rappresenti una procedura di indubbia efficacia nel trattamento dell’ernia inguinale, tuttora permangono dubbi in relazione alla storia naturale del plug. In particolare, il plug può andare incontro a coartazione (shrinkage) con formazione di un “meshoma” responsabile di una sintomatologia dolorosa cronica. Più raramente, il plug può migrare e provocare erosione delle strutture anatomiche circostanti. Nel passato sono stati proposti alcuni devices per cercare di risolvere il problema della migrazione; nessuno di questi, tuttavia, ha raggiunto la popolarità dei plug conici o a forma di fiore. Il presente lavoro riporta i risultati di uno studio pilota condotto con l’impiego di un nuovo device tridimensionale, il NeT Plug & Patch. I risultati dopo 12 mesi di follow-up, hanno dimostrato una ridotta incidenza di dolore postoperatorio e cronico, senza rischio di migrazione. Inoltre è stata registrata una compliance soddisfacente sia dei pazienti che degli operatori. La protesi NeT Plug & Patch ha dimostrato di poter realizzare un’ernioplastica semplice ed efficace per la riparazione dell’ernia inguinale.

  12. [Validazione del Gambling Disorder Screening Questionnaire, un questionario diagnostico autosomministrato per il gioco d'azzardo patologico basato sui criteri del DSM-5].

    PubMed

    Villella, Corrado; Pascucci, Marco; de Waure, Chiara; Bellomo, Antonello; Conte, Gianluigi

    2016-01-01

    RIASSUNTO. Scopo. Il DSM-5 presenta delle modifiche nei criteri diagnostici per il gioco d'azzardo patologico, rispetto alla precedente edizione del manuale; è pertanto necessario sviluppare nuovi strumenti diagnostici. Questo studio ha valutato le caratteristiche psicometriche del Gambling Disorder Screening Questionnaire (GDSQ), un questionario sviluppato per l'autosomministrazione, basato sui criteri diagnostici del DSM-IV e del DSM-5 per il gioco d'azzardo patologico, misurandone la validità e la consistenza interna e sottoponendo il questionario all'analisi delle componenti principali. Metodi. 71 pazienti reclutati da un ambulatorio dedicato al gioco d'azzardo patologico e 70 controlli sono stati valutati con il GDSQ, con il South Oaks Gambling Screen (SOGS) e con valutazione psichiatrica. Risultati. Il test ha mostrato una buona sensibilità, specificità, consistenza interna, correlazione con il SOGS. L'esclusione del criterio degli atti illeciti e l'abbassamento del punteggio di cut-off a quattro criteri positivi, come suggerito dal DSM-5, migliora la sensibilità e consistenza interna del test. Discussione e conclusioni. Il GDSQ può essere considerato un utile test di screening per il gioco d'azzardo patologico. Inoltre, questo studio conferma il miglioramento nell'accuratezza diagnostica dei criteri elencati nella quinta edizione del Manuale Diagnostico e Statistico dei Disturbi Mentali rispetto alla precedente edizione.

  13. [Valutazione delle guardie di sicurezza privata attraverso la Suicide Probability Scale e la Brief Symptom Inventory].

    PubMed

    Dogan, Bulent; Canturk, Gurol; Canturk, Nergis; Guney, Sevgi; Özcan, Ebru

    2016-01-01

    RIASSUNTO. Scopo. Lo scopo di questo studio è stato quello di investigare l'influenza della probabilità di suicidio, con le sue caratteristiche sociodemografiche, e di procurare i dati per la prevenzione del suicidio tra le guardie di sicurezza privata che lavorano in condizioni di stress, essendo a contatto ininterrottamente con eventi negativi e traumatici di vita durante il loro lavoro. Metodi. Hanno partecipato allo studio 200 guardie di sicurezza privata e 200 persone dell'Università di Ankara. Per raccogliere i dati sono stati utilizzati un questionario riguardante le condizioni sociodemografiche dei partecipanti, la Suicide Probability Scale (SPS) e la Brief Symptom Inventory (BSI). Risultati. Genere, stato civile, stipendio, credenze religiose, vivere una situazione di pericolo di vita, passato di tentativi di suicidio, fumare e non avere una malattia cronica hanno causato statisticamente una differenza significativa sui punteggi di SPS tra il gruppo di guardie di sicurezza privata e quello di controllo. In aggiunta, c'è stata una correlazione positiva statisticamente significativa tra i punteggi totali delle sottoscale di SPS e quelli di BSI. Conclusioni. Allo stesso modo degli agenti di polizia e dei gendarmi, le guardie di sicurezza privata sono ad alto rischio di commettere e tentare il suicidio trovandosi in condizioni stressanti di lavoro e anche soffrendo del trauma secondario. È necessario che essi siano consapevoli della propria tendenza al suicidio e avere controlli psichiatrici regolari.

  14. INFEZIONI VIRALI CONGENITE, PERINATALI E NEONATALI VIRAL INFECTIONS OF THE FETUS AND NEWBORN INFANT

    PubMed Central

    Tremolada, Sara; Delbue, Serena; Ferrante, Pasquale

    2009-01-01

    Riassunto Alcuni virus possono essere trasmessi verticalmente da madre a figlio in seguito allo sviluppo, da parte della madre, di un’infezione primaria, ricorrente o cronica. La trasmissione materno-fetale dei virus, che può avvenire in utero (infezione congenita), durante il travaglio del parto (infezione perinatale), oppure attraverso l’allattamento (infezione postnatale), può causare aborto spontaneo, morte fetale, ritardo di crescita intrauterino, anomalie congenite e patologie neonatali o postnatali di diversa entità. Alcuni fattori di rischio sembrano influenzare l’incidenza di trasmissione materno-fetale dei virus, come ad esempio la presenza di altre infezioni virali, la carica virale materna, il tipo di infezione (primaria o ricorrente), la durata della rottura delle membrane, la modalità con cui avviene il parto, le condizioni socio-economiche e l’allattamento. Oggi è possibile prevenire la trasmissione materno-fetale di molti virus grazie all’utilizzo di vaccini, immunizzazione passiva e farmaci antivirali. Il rischio di trasmissione delle infezioni perinatali e postnatali, inoltre, può essere diminuito evitando l’allattamento o ricorrendo ad un parto cesareo. PMID:19216201

  15. Legends about Legends: Abraham Eleazar's Adaptation of Nicolas Flamel.

    PubMed

    Priesner, Claus

    2016-02-01

    This paper explores the relationship between three illustrated alchemical treatises, all of which are associated with Jewish adepts: the famous Le Livre des figures hieroglyphiques attributed to Nicolas Flamel, and two treatises published in 1735 in Erfurt-the Uraltes Chymisches Werckh and the Donum Dei. The Werckh is supposedly written by Rabbi Abraham Eleazar, while the Donum Dei is attributed to an ancient alchemist-cabalist, Rabbi Samuel Baruch. I argue that these authors are fictitious, and that both works were in fact written in the early eighteenth century by their supposed editor, the probably pseudonymous Julius Gervasius. Gervasius connects the Werckh with the legend of Nicolas Flamel by suggesting that it is based on the original, Jewish manuscript which helped Flamel to find the Stone of the Sages. Gervasius used various strategies to confer a sense of Jewish "authenticity" on these works, borrowing from contemporary (non-Jewish) perceptions of Jewish ritual, Hebrew language, and Christian Cabala. The Werckh also borrows and adapts a sequence of allegorical illustrations from those in pseudo-Flamel's Livre, and I compare the two sets of figures and, where possible, interpret them. I conclude that the later works in fact teach us far more about the state of alchemy in the seventeenth and eighteenth centuries than they do about either medieval alchemy or Judaism.

  16. Clinical competence in nursing: A concept analysis.

    PubMed

    Notarnicola, Ippolito; Petrucci, Cristina; De Jesus Barbosa, Maria Rosimar; Giorgi, Fabio; Stievano, Alessandro; Lancia, Loreto

    2016-01-01

    Introduzione. In campo infermieristico la ‘competenza clinica’ è una questione centrale per l’assistenza al paziente e è fondamentale una chiara comprensione del concetto sia per la formazione che per la disciplina infermieristiche. Scopo. Effettuare un analisi del concetto di ‘competenza clinica’ in campo infermieristico. Metodo: E’ stato utilizzato il metodo descritto da Walker e Avant. È stata effettuata una revisione sistematica della letteratura su database internazionali ( PubMed, CINAHL, Scopus, Cochrane, Ovid, Open Grey ) dal 1993 al 2015. Negli articoli reperiti è stata esaminata l’utilizzazione del concetto in esame. Risultati. Sono stati descritti tutti gli 8 step previsti dal modello di Walker e Avant sulla base dei risultati della revisione sistematica della letteratura. Sono stati identificati e discussi gli attributi, gli antecedenti, le conseguenze e i riferimenti empirici della competenza clinica in campo infermieristico e sono stati costruiti i casi modello, limite e contrario. E’ stata discussa anche la rilevanza del concetto sia per la formazione che per lo sviluppo professionale in campo infermieristico. Conclusioni. Questa analisi di concetto ha portato a definire la ‘competenza clinica’ in campo infermieristico come ‘un insieme di capacità, conoscenze, attitudini e abilità che ciascun infermiere deve possedere per effettuare in maniera accettabile tutte quelle attività direttamente correlate all’assistenza al paziente, in uno specifico contesto clinico e in specifiche circostanze allo scopo di promuovere, mantenere e ristabilire la salute dei pazienti’.

  17. The PICASSO digital detector for Diffraction Enhanced Imaging at ELETTRA

    NASA Astrophysics Data System (ADS)

    Arfelli, F.; Astolfo, A.; Menk, R.-H.; Rigon, L.; Zanconati, F.; De Pellegrin, A.; Chen, R. C.; Dreossi, D.; Longo, R.; Vallazza, E.; Castelli, E.

    2010-07-01

    A clinical mammography program is in progress at the medical beamline SYRMEP of the Italian synchrotron radiation laboratory ELETTRA in Trieste. A conventional screen-film system is utilized as detector for the examinations on patients. For the next experimental step a digital detector has been designed taking into account the essential requirements for mammography such as high spatial and contrast resolution, high efficiency for low dose examinations and high speed for short acquisition time. A double-layer prototype has already been tested in the frame of the PICASSO project. In addition, an analyzer crystal set-up for Diffraction Enhanced Imaging (DEI) has been available for many years at the SYRMEP beamline. Applying the DEI technique several successful experiments have been carried out in biomedical imaging and in particular in-vitro breast imaging utilizing commercially available detectors. Recently a system upgrade yielded a double-crystal analyzer set-up with improved stability and higher angular resolution. In this study the PICASSO detector has been utilized in combination with the new analyzer set-up for imaging in-vitro breast tissue samples. In order to test the potential of the combined system planar and tomographic images have been acquired and the first results are here presented.

  18. Nursing diagnoses and theoretical frameworks in neonatal units: a literature review.

    PubMed

    Di Sarra, Luca; D'Agostino, Fabio; Cocchieri, Antonello; Vellone, Ercole; Zega, Maurizio; Alvaro, Rosaria

    2016-01-01

    Obiettivo: Identificare le diagnosi infermieristiche ed i quadri teorici utilizzati nelle unità neonatali attraverso una revisione della letteratura. Metodo: Per effettuare questo studio sono stati usati database come Cinahl, Medline e Lilacs. I descrittori usati sono: "Diagnosi infermieristica" AND "Modelli, Infermieristici" OR "Teoria infermieristica" AND "Infante" OR "Neonato". La ricerca era limitata agli arti- coli pubblicati dal 2000 al novembre 2013. Venivano selezionati soltanto gli studi scritti in inglese, spagnolo, portoghese e italiano. Risultati: Nella revisione della letteratura sono state identificate due tassonomie e sei impor- tanti quadri teorici. Le diagnosi infermieristiche più frequentemente individuate sono: intol- leranza alle attività, ridotta ventilazione spontanea, modello di respirazione inefficace, rischio di aspirazione, ritardo nella crescita e nello sviluppo, allattamento al seno inefficace, modello di alimentazione infantile inefficace, ipertermia/ipotermia, rischio di infezione, alterazione dell’integrità cutanea, interruzione dei processi familiari, rischio di compromissione della genitorialità, rischio di riduzione dell’attaccamento. Sono state identificate diagnosi appli- cabili alla sfera psico-sociale genitoriale che consentivano una valutazione integrale del neonato, compresa la famiglia. Conclusioni: Le diagnosi infermieristiche consentono agli infermieri che lavorano nelle unità neonatali l’opportunità di gestire efficacemente il processo assistenziale, nonché la disponibilità dei dati necessari per il continuo miglioramento della qualità nella cura infer- mieristica. L'utilizzo di un unico modello o di più modelli di riferimento costituisce un modo per aiutare l'agire professionale.

  19. Laparoscopic cholecystectomy and concomitant diseases Effectiveness of the single step treatment.

    PubMed

    Caglià, Pietro; Tracia, Angelo; Amodeo, Luca; Tracia, Lucio; Amodeo, Corrado; Veroux, Massimiliano

    2015-01-01

    Con il diffondersi della chirurgia video-laparoscopica si è posto in maniera crescente il problema di dover affrontare più patologie addominali coesistenti. La colecistectomia laparoscopica, in particolare, è stata spesso associata ad altre procedure laparoscopiche quali appendicectomia, splenectomia, ernioplastica o laparoplastica, interventi ginecologici ed altri. Sono stati esaminati retrospettivamente i dati relativi a 23 pazienti sottoposti a colecistectomia video-laparoscopica simultaneamente ad altri interventi. Solo di 19 pazienti è stato possibile raccogliere tutte le notizie cliniche necessarie alla valutazione. La colelitiasi rappresentava la prima patologia in 11 pazienti. La colecistectomia laparoscopica è stata associata a 1 fundoplicatio sec. Nissen, 1 adrenalectomia destra, 6 ernioplasiche inguinali, 2 laparoplastiche, 1 asportazione di cisti ovarica. In altre 8 pazienti (4 appendiciti sub-acute o croniche, 1 cisti endometrioide ovarica, 1 dermoide ovarico, 2 varicoceli sx) la calcolosi della colecisti è stata diagnosticata come patologia concomitante e trattata simultaneamente con il consenso del paziente. Tutti gli interventi sono stati eseguiti in anestesia generale e dallo stesso team. Nonostante il limitato numero di pazienti inclusi nella nostra serie, i risultati sono simili a quelli riportati da altri Autori. Il lieve aumento dei tempi operatori, rilevato durante le procedure chirurgiche associate, viene compensato dall’innegabile vantaggio di una singola esposizione all’anestesia e di una unica degenza ospedaliera. Particolare attenzione va comunque riservata alla valutazione dei fattori di rischio relativi ai singoli pazienti.

  20. A primary subcutaneous hydatid cyst in the thigh A case report.

    PubMed

    Salamone, Giuseppe; Licari, Leo; Randisi, Brenda; Di Carlo, Paola; Tutino, Roberta; Falco, Nicolò; Augello, Giuseppe; Raspanti, Cristina; Cocorullo, Gianfranco; Gulotta, Gaspare

    2016-04-08

    L’Echinococcus spp. rappresenta il movente eziopatogenetico della malattia idatidea, patologia a carattere endemico in diverse parti del mondo, con tipica localizzazione della cisti da echinococco, prodotto del ciclo vitale del parassita, in sede polmonare od epatica. Ciononostante le localizzazioni atipiche della malattia esistono e rappresentano circa il 1,6% dei casi, la più comune delle quali certamente quella sottocutanea. I dati a disposizione circa la diagnosi ed il trattamento delle rare forme a localizzazione atipica risultano disomogenei e pochi dirimenti circa uno standard diagnostico-terapeutico da adottare. Si è voluto presentare dunque il caso di una donna di 68 anni che lamentava la comparsa di una tumefazione al terzo prossimale della coscia dx che tendeva ad incrementarsi volumetricamente nel tempo. Dopo diverse indagini cliniche, oltre che una accurata anamnesi, il sospetto di cisti idatidea è stato confermato. La patologia è stata trattata secondo uno schema terapeutico chirurgico e farmacologico ben dettagliato. La raccolta di questi dati si prefigge lo scopo di pianificare, in accordo con la letteratura scientifica e la review dei case-report esistenti, linee guida nel percorso assistenziale di questa rara manifestazione di una comune malattia.

  1. B-lymphocyte activating factor levels are increased in patients with Wegener's granulomatosis and inversely correlated with ANCA titer.

    PubMed

    Bader, Lucius; Koldingsnes, Wenche; Nossent, Johannes

    2010-09-01

    Circulating autoantibodies against neutrophils (ANCA) are a distinctive finding in patients with Wegener's granulomatosis (WG). B-lymphocyte activating factor (BAFF) promotes autoantibody production by increasing B cell survival and proliferation. We investigated serum BAFF levels (s-BAFF) in a WG patient cohort in relation to ANCA titers and disease activity. Baseline data were obtained in twenty-two WG patients (55% female, age 44 years, disease duration 1 year). S-BAFF was determined by capture ELISA and associations between s-BAFF, clinical (Birmingham Vasculitis Activity Score (BVAS), Vasculitis Damage Index (VDI) and Disease Extent Index (DEI)) and biochemical (C-reactive protein (CRP), IgG and ANCA) disease measures were analysed in a cross sectional as well as longitudinal analysis. S-BAFF was increased in WG patients compared to healthy controls (1.8 vs. 0.55 ng/ml, p < 0.01). S-BAFF was higher in ANCA negative than ANCA-positive WG sera (2.16 vs. 1.29 ng/ml, p < 0.01), correlated independently and inversely with ANCA levels (Rs -0.48, p < 0.01) but did not correlate with CRP, BVAS, DEI or VDI scores. Individual s-BAFF profiles were stable over time in 68% of patients. The finding of a negative correlation between ANCA levels and s-BAFF that is independent of steroid treatment indicates that BAFF does not directly drive ANCA production in WG.

  2. Comparison of weight gain and energy intake after subthalamic versus pallidal stimulation in Parkinson's disease.

    PubMed

    Sauleau, Paul; Leray, Emmanuelle; Rouaud, Tiphaine; Drapier, Sophie; Drapier, Dominique; Blanchard, Sophie; Drillet, Gwenolla; Péron, Julie; Vérin, Marc

    2009-10-30

    To compare body mass index (BMI) and daily energy intake (DEI) after subthalamic versus pallidal deep brain stimulation (DBS). Weight gain following DBS in Parkinson's disease patients remains largely unexplained and no comparison of subthalamic and pallidal (GPi) stimulation has yet been performed. BMI and DEI, dopaminergic drug administration and motor scores were recorded in 46 patients with PD before STN (n = 32) or GPi (n = 14) DBS and 3 and 6 months after. At M6, BMI had increased by an average of 8.4% in the STN group and 3.2% in the GPi group. BMI increased in 28 STN and 9 GPi patients. This increase was significantly higher in the STN group (P < 0.048) and the difference remained significant after adjustment for reduced dopaminergic medication; 28.6% of GPi patients were overweight at 6 months (14.3% preoperatively) versus 37.5% of STN patients (21.9% preoperatively). Changes in BMI were negatively correlated with changes in dyskinesia in the GPi-DBS group. Food intake did not change in the two groups, either quantitatively or qualitatively. Frequent weight gain, inadequately explained by motor improvement or reduced dopaminergic drug dosage, occurred in subthalamic DBS patients. The difference between groups suggests additional factors in the STN group, such as homeostatic control center involvement.

  3. Dynamic electronic institutions in agent oriented cloud robotic systems.

    PubMed

    Nagrath, Vineet; Morel, Olivier; Malik, Aamir; Saad, Naufal; Meriaudeau, Fabrice

    2015-01-01

    The dot-com bubble bursted in the year 2000 followed by a swift movement towards resource virtualization and cloud computing business model. Cloud computing emerged not as new form of computing or network technology but a mere remoulding of existing technologies to suit a new business model. Cloud robotics is understood as adaptation of cloud computing ideas for robotic applications. Current efforts in cloud robotics stress upon developing robots that utilize computing and service infrastructure of the cloud, without debating on the underlying business model. HTM5 is an OMG's MDA based Meta-model for agent oriented development of cloud robotic systems. The trade-view of HTM5 promotes peer-to-peer trade amongst software agents. HTM5 agents represent various cloud entities and implement their business logic on cloud interactions. Trade in a peer-to-peer cloud robotic system is based on relationships and contracts amongst several agent subsets. Electronic Institutions are associations of heterogeneous intelligent agents which interact with each other following predefined norms. In Dynamic Electronic Institutions, the process of formation, reformation and dissolution of institutions is automated leading to run time adaptations in groups of agents. DEIs in agent oriented cloud robotic ecosystems bring order and group intellect. This article presents DEI implementations through HTM5 methodology.

  4. Diagnosis of CCSVI in Meniere syndrome.

    PubMed

    Bruno, Aldo; Quarto, Gennaro; Califano, Luigi; Mastrangelo, Diego; De Vizia, Marcella; Salafia, Francesca; Bernardo, Benedetto

    In questo lavoro gli autori hanno valutato la possibilità di diagnosticare l’insufficienza venosa cronica cerebro-spinale (CCSVI) nei pazienti affetti da sindrome di Meniére resistente alle terapie mediche. Da aprile 2013 al luglio 2014 sono stati valutati 140 pazienti, 85 femmine, 55 maschi di età compresa tra 32 a 68 anni, con un’età media di 46 aa, affetti da sindrome di Meniere clinicamente definita secondo i criteri AAO 1995. I pazienti sono stati sottoposti ad un esame eco-colordoppler delle vene del collo e dei vasi venosi intracranici secondo il metodo di Zamboni. L’esame è stato eseguito anche in 100 pazienti sani, non affetti da malattia neurologica o audiovestibolare, di età simile a quella dei pazienti arruolati nello studio. L’incidenza della CCSVI, diagnosticata secondo il protocollo sviluppato dal Prof. Zamboni, nei pazienti con sindrome di Meniere è stata del 90%, con una presenza di lesioni più gravi sul lato interessato in casi unilaterali. Nella popolazione di controllo sono state rilevate anomalie compatibili con la CCSVI in soli tre pazienti (3%) comunque asintomatici. Vi è un’alta incidenza di CCSVI nei pazienti con malattia di Meniere clinicamente definita, in una percentuale tale da mettere in dubbio un evento casuale, soprattutto data la bassa prevalenza nel gruppo di controllo.

  5. Determinants of marital behaviour in five Apennine communities of Central Italy inferred by surname analysis, repeated pairs and kinship estimates.

    PubMed

    Capocasa, M; Taglioli, L; Anagnostou, P; Paoli, G; Danubio, M E

    2014-02-01

    The work makes use of surname analysis, repeated pairs and kinship estimates in 11,009 marriage records celebrated in five communities of the Italian Central Apennine (Celano, Lecce dei Marsi, Ortucchio, Roio, Villavallelonga) from 1802 to 1965 with the objective to deepen knowledge of the relative influence of several determinants on their marital behaviour. These towns are part of the same geographic and economic environment: the slopes of the ancient Fucino Lake. This work further elaborates the results from previous studies on the bio-demographic model of the region. The data were analyzed according to three periods of approximately 50 years. Results show the highest inbreeding coefficients in the pastoral towns of Roio and Villavallelonga. Repeated pair analysis highlights a certain degree of population subdivision which declined in time in Celano, Lecce dei Marsi and Ortucchio. The highest and increasing values of RP-RPr in time in Roio suggest a general reduction in genetic heterogeneity. This is possibly due to the celebration of marriages among families selected on the economic basis of pastoralism, as this town historically has had a leading tradition of sheep-farming. Villavallelonga, excluding isonymous marriages, shows an increase in repeated pair unions in time, thus revealing a substructure with marriages among preferred lineages. This is in line with previous results on consanguineous marriages which indicated the tendency of avoiding unions between close relatives in this small geographic isolate. This study demonstrates the influence of geographical (altitude) and social factors (pastoralism) on the marital structures of the investigated populations.

  6. Multidisciplinary approach to follicular thyroid carcinoma with giant mandibular and multiple sites metastases Case report.

    PubMed

    De Pasquale, Loredana; Rabbiosi, Dimitri; Bardazzi, Alessandro; Autelitano, Luca; Moro, Giacomina Pierina; Ghilardi, Giorgio

    2014-01-01

    I tumori metastatici in genere hanno una cattiva prognosi, con sopravvivenza breve e raramente sono candidabili al trattamento chirurgico. Nel caso dei carcinomi differenziati della tiroide, la prognosi è solitamente migliore, grazie alla possibilità di un approcio multidisciplinare e soprattutto al trattamento radiometabolico dei secodarismi, dopo l’asportazione del tumore primitivo. Il caso presentato riguarda una donna di 65 anni, che è giunta alla nostra osservazione per una tumefazione mandibolare, risultata successivamente una metastasi da carcinoma follicolare della tiroide, a partenza da un voluminoso gozzo cervico-mediastinico normofunzionante, con ulteriori secondarismi a livello polmonare. Dopo un accurato studio pre-operatorio la Paziente è stata sottoposta a resezione della mandibola sinistra con ricostruzione mediante una protesi metallica e a tiroidectomia totale. Successivamente è stata trattata con quattro cicli di terapia radiometabolica con buona risposta. La Paziente è viva, senza ulteriore progressione di malattia a un follow-up di quarantasei mesi. Anche nei casi di tumori differnziati della tiroide in fase metastatica, l’opzione chirurgica va presa in considerazione per consentire alle terapie complementari di migliorare la prognosi in termini di sopravvivenza.

  7. Draft environmental impact statement for construction and operation of the proposed Bangor Hydro-Electric Company`s second 345-kV transmission tie line to New Brunswick

    SciTech Connect

    1993-10-01

    This Draft Environmental Impact Statement (DEIS) was prepared by the US Department of Energy (US DOE). The proposed action is the issuance of Presidential Permit PP-89 by DOE to Bangor Hydro-Electric Company to construct and operate a new international transmission line interconnection to New Brunswick, Canada that would consist of an 83.8 mile (US portion), 345-kilovolt (kV) alternating current transmission line from the US-Canadian border at Baileyville, Maine to an existing substation at Orrington, Maine. The principal environmental impacts of the construction and operation of the transmission line would be incremental in nature and would include the conversion of forested uplands (mostly commercial timberlands) and wetlands to right-of-way (small trees, shrubs, and herbaceous vegetation). The proposed line would also result in localized minor to moderate visual impacts and would contribute a minor incremental increase in the exposure of some individuals to electromagnetic fields. This DEIS documents the purpose and need for the proposed action, describes the proposed action and alternatives considered and provides a comparison of the proposed and alternatives routes, and provides detailed information on analyses of the environmental consequences of the proposed action and alternatives, as well as mitigative measures to minimize impacts.

  8. Ethical issues in astrobiology: a Christian perspective (Invited)

    NASA Astrophysics Data System (ADS)

    Randolph, R. O.

    2009-12-01

    With its focus on the origin, extent, and future of life, Astrobiology raises exciting, multidisciplinary questions for science. At the same time, Astrobiology raises important questions for the humanities. For instance, the prospect of discovering extraterrestrial life - either intelligent or unintelligent - raises questions about humans’ place in the universe and our relationship with nature on planet Earth. Fundamentally, such questions are rooted in our understanding of what it means to be human. From a Christian perspective, the foundational claim about human nature is that all persons bear the "imago dei", the image of God. This concept forms the basis for how humans relate to one another (dignity) and how humans relate to nature (stewardship). For many Christians the "imago dei" also suggests that humans are at the center of the universe. The discovery of extraterrestrial life would be another scientific development - similar to evolution - that essentially de-centers humanity. For some Christian perspectives this de-centering may be problematic, but I will argue that the discovery of extraterrestrial life would actually offer a much needed theological corrective for contemporary Christians’ understanding of the "imago dei". I will make this argument by examining two clusters of ethical issues confronting Astrobiology: 1. What ethical obligations would human explorers owe to extraterrestrial life? Are there ethical obligations to protect extraterrestrial ecosystems from harm or exploitation by human explorers? Do our ethical considerations change, if the extraterrestrial life is a “second genesis;” in other words a form of life completely different and independent from the carbon-based life that we know on Earth? 2. Do we have an ethical obligation to promote life as much as we can? If human explorers discover extraterrestrial life and through examination determine that it is struggling to survive, do we have an ethical obligation to assist that

  9. Regional tectonic context, timing, and intrusion mechanism of gneiss domes, eastern Papua New Guinea, from offshore seismic reflection and well data

    NASA Astrophysics Data System (ADS)

    Fitz, G. G.; Mann, P.; Lavier, L. L.

    2011-12-01

    The D'Entrecasteaux Island (DEI) gneiss domes are fault-bounded topographic domes with ~2.5 km of relief exposing ultrahigh-pressure (UHP) and high-pressure (HP) metamorphic gneisses and migmatites that began to exhume ~8 Ma in a zone of continental extension 120 km west of the tip of the westward propagating Woodlark seafloor spreading. Two previous models for the origin and emplacement of the gneiss domes include: 1) the domes are metamorphic core complexes formed as footwall blocks on north-dipping, low-angle (<30 deg.) normal faults of Plio-Pleistocene age; and 2) the domes are diapirs of buoyant lower crustal material extruding vertically through narrow zones of extension (~30 km wide) in an overlying dense layer of ultramafic rock. To study the style of continental extension accompanying exhumation of the DEI gneiss domes, we interpreted a loose grid of 1,518 km of 2-D multi-channel seismic (MCS) reflection data and well data from the offshore areas surrounding the DEI, including the Trobriand basin and the Goodenough basin. MCS and well data show the Trobriand basin initially formed as an asymmetrical Miocene forearc basin overlying the south-dipping Trobriand subduction zone that underwent a late Miocene (~11-9 Ma) inversion event that deformed and uplifted the basin's southern and northern margins. Since extension began 8 Ma, the Trobriand basin has evolved as a symmetrical sag basin with 1-3 km of subsidence and few normal faults deforming the upper crust. The Goodenough basin to the south of the Trobriand basin formed as an asymmetrical and southward-tilted half-graben whose master normal fault is the Owen-Stanley fault zone (OSFZ) along the southern edge of the basin. Reconstruction on this structure based on the geometry of faults in the hanging wall indicates a minimum slip on the order of 10 km along a listric fault plane shallowly dipping to the north. The western extension of the OSFZ dips 18 deg. to 24 deg. north along the northern edge of the

  10. The protective effect of melatonin on remote organ liver ischemia and reperfusion injury following aortic clamping.

    PubMed

    Ozsoy, Mustafa; Gonul, Yucel; Ozkececi, Ziya Taner; Bali, Ahmet; Celep, Ruchan Bahadir; Koçak, Ahmet; Adali, Fahri; Tosun, Murat; Celik, Sefa

    2016-01-01

    Dopo il ripristino della circolazione sanguigna e dell’ossigenazione possono verificarsi gravi danni locali e sistemici ai tessuti temporaneamente ischemici, noti come danni da riperfusione. Lo scopo di questo studio è stato quello di indagare sui possibili effetti protettivi della melatonina nei confronti dei danni sistemici da riperfuzione nel tessuto epatico a seguito dell’occlusione dell’aorta sottorenale. Per questo studio sono stati impiegati un totale di 21 ratti Wistar-albini di sesso maschile, suddivisi in tre gruppi: I gruppo – laparotomia e contemporanea dissezione dell’aorta infrarenale; II gruppo – somministrazione intraperitoneale di circa 1 ml di fisiologica al 0,9% di NaCl 30’ prima e dopo l’operazione di occlusione. Dopo la laparotomia e sua dissezione, l’aorta sottorenale è clampata per 30’ e quindi riabitata al circolo di riperfusione per 2 ore; III gruppo – 30’ prima del clampaggio dell’aorta sottorenale è stata somministrata la malatonina, seguita dal clampaggio aortico per 30’ e un periodo di riperfusione di 2 ore. Sono stati quindi dosati i tassi sierici di aspartate aminotransferasi, alanine aminotransferasi, and lattato dehydrogenase, risultati significativamente più elevate nei gruppi II e III rispetto al gruppo I di controllo. Gli esami di laboratorio sono tornati ai livelli normali nel III gruppo dopo il trattamento. Sebbene si sia avuto un decremento del tasso sierico di IL-1β, IL-6, IL-18, TNF-α, e IFN- γ nel gruppo trattato con melatonina, questo decremento ha assunto valore statisticamente significativo per i livelli sierici di IL- 18, TNF-α, e IFN- γ in paragone con quanto osservato nel II gruppo. I tassi sierici dello stato totale di antiossidanti tissutali (TOC) e dell’indice di stress ossidativo dei tessuti (OSI) sono risultati diminuiti e quelli della capacità antiossidante (TAC) risultano accresciuti dalla melatonina. Il risultato di questo studio suggerisce effetti antiossidanti della

  11. Our experience in the management of obstructing colorectal cancer.

    PubMed

    Formisano, Vincenzo; Di Muria, Antonio; Connola, Giorgio; Cione, Gianpiero; Falco, Luigina; De Angelis, Carlo Paolo; Angrisani, Luigi

    2014-01-01

    Riportiamo la nostra esperienza retrospettiva sulle occlusioni intestinali da cancro colorettale. Negli ultimi 6 anni, abbiamo operato 238 pazienti affetti da cancro colorettale. I tumori complicati sono stati 136 (56%), 115 dei quali stenosanti (86%) e 19 perforati (14%). In 23 pazienti (20%) il tumore stenosante del colon era a destra ed in 92 (80%) a sinistra. Questi ultimi sono stati suddivisi retrospettivamente in 4 gruppi, in relazione all’intervento chirurgico eseguito: 18 (19%) colostomie decompressive; 32 (35%) procedure in due stadi: 25 operazioni di Hartmann e 7 colectomie totali con ileostomia terminale; 7 (8%) procedure in uno stadio, con ileostomia di protezione: 4 colectomie totali e 3 resezioni del colon con wash-out; 35 (38%) procedure in uno stadio con anastomosi primaria + wash-out o milking. I decessi sono stati 8/115, con un tasso di mortalità operatoria globale del 7%. Il tasso di fistola anastomotica è stato del 10%, riguardando 6/58 pazienti con anastomosi, 5 dei quali hanno richiesto un reintervento chirurgico. Complessivamente, circa 2/3 dei decessi perioperatori sono avvenuti per complicanze generali ed un terzo per deiscenza dell’anastomosi. L’occlusione intestinale da cancro colorettale è associata ad un’elevata mortalità operatoria ed una prognosi peggiore, in termini di recidiva e di sopravvivenza. La colostomia decompressiva può essere considerata come un’opzione valida solo nella malattia avanzata o nel paziente in condizioni generali scadute. La resezione anastomosi primaria rappresenta il gold-standard in pazienti selezionati con un basso rischio anestesiologico, sia sotto forma di resezione tipica con washout, sia come colectomia subtotale. Una colostomia o ileostomia temporanea di protezione può essere proposta per i pazienti con un rischio anestesiologico intermedio. Nei casi ad alto rischio o in avanzato stato occlusivo, oppure in presenza di simultanea perforazione del colon o di malattia metastatica o

  12. Splenic abscess after splenic blunt injury angioembolization.

    PubMed

    Tartaglia, Dario; Galatioto, Christian; Lippolis, Piero Vincenzo; Modesti, Matteo; Gianardi, Desirée; Bertolucci, Andrea; Cucinotta, Monica; Zocco, Giuseppe; Seccia, Massimo

    2014-11-03

    L’angioembolizzazione splenica è una efficace procedura nel corso del trattamento non operativo dei pazienti emodinamicamente stabili con traumi splenici di grado OIS III, IV, V. L’ascesso spenico rappresenta una rara complicanza maggiore di questa procedura. Di seguito riportiamo il caso di un paziente di 38 anni, giunto in Pronto Soccorso dopo una caduta accidentale domestica, con contusione del quadrante superiore sinistro dell’addome. La TC addome documentava una frattura del polo inferiore della milza, con pseudoaneurismi intraparenchimali (grado IV OIS). Vista la stabilità emodinamica, il paziente veniva sottoposto a trattamento non operatvo. Successivamente si eseguiva un’angioembolizzazione della parte distale dell’ arteria splenica con spongostan gel e spirali metalliche. Per la comparsa di febbre e per l’evidenza di sepsi agli esami ematochimici, si effettuava un’ ulteriore TC addome che evidenziava la presenza di una voluminosa raccolta di circa 11 cm all’ interno della milza con multiple bolle aree nel suo contesto, con segni di emoperitoneo diffuso nei recessi addominali. Per tale motivo, ad una settimana dalla procedura, il paziente veniva sottoposto ad intervento chirurgico di splenectomia con evacuazione del versamento ematico. Gli esami colturali eseguiti sull’ematoma perisplenico risultavano negativi, ma l’esame istologico della milza documentava multiple aree ascessualizzate ed emorragiche. Dopo un ciclo di terapia antibiotica a largo spettro con Tigeciclina e Teicoplanina, il paziente veniva dimesso in sedicesima giornata post-operatoria. In letteratura, è stato riportato che gli ascessi splenici dopo la procedura di angioembolizzazione splenica nel corso di un trattamento non operativo dei traumi splenici, si verificano nel range dello 0-1,9%. In circa un terzo dei casi richiedono un trattamento chirurgico. Nel caso riportato l’ascesso splenico si è sviluppato nel giro di una settimana dalla procedura. In conclusione

  13. Low-temperature thermochronologic constraints on cooling and exhumation trends along conjugate margins, within core complexes and eclogite-bearing gneiss domes of the Woodlark rift system of eastern Papua New Guinea

    NASA Astrophysics Data System (ADS)

    Fitzgerald, P. G.; Baldwin, S.; Bermudez, M. A.; Miller, S. R.; Webb, L. E.; Little, T.

    2012-12-01

    In eastern Papua New Guinea, active sea-floor spreading within the Woodlark Basin has been propagating westward since at least 6 Ma into heterogeneous crust of the Woodlark Rift. The seafloor spreading system divides the northern conjugate margin (Woodlark Rise) from the southern margin (Pocklington Rise). West of the seafloor spreading rift-tip are high-standing extensional gneiss domes and core complexes of the D'Entrecasteaux Islands (DEI). Domes comprise amphibolite and eclogite-facies gneisses, and Pleistocene granitoid intrusions. Flanked by mylonitic shear zone carapaces and normal faults, the domes are juxtaposed against an upper plate that includes ultramafic rocks and gabbro, correlated with the Papuan ultramafic belt. Petrologic and structural evidence from the DEI has been interpreted as evidence for diapiric ascent of the largely felsic domes, with thermo-mechanical modeling proposing (U)HP exhumation in terms of diapiric flow aided by propagating extension, with feedback between the two. Core complexes lacking evidence for diapiric-aided exhumation include the Prevost Range (eastern Normanby Island), Dayman Dome (Papuan Peninsula), and Misima Island (southern conjugate margin). Thermochronology is being applied to understand the thermal and exhumation history, and hence help constrain mechanisms of (U)HP exhumation. AFT and AHe ages from samples near sea-level along conjugate margins and DEI range from ca. 12 Ma to <1 Ma, generally decreasing from east to west, although with some localized variation. Confined track length distributions (CTLD), obtained using 252Cf implantation, generally indicate rapid cooling (means ≥~14 μm), except on Goodenough Island, the western-most and highest-standing dome. On Goodenough Island, samples from the core zone have AFT ages from ~3 - <1 Ma with age decreasing with decreasing elevation. Core zone samples have mean track lengths (7-13 μm) and are positively skewed, whereas samples from shear zones are younger (<1

  14. Risk stratification systems for surgically treated localized primary Gastrointestinal Stromal Tumors (GIST). Review of literature and comparison of the three prognostic criteria: MSKCC Nomogramm, NIH-Fletcher and AFIP-Miettinen.

    PubMed

    Belfiori, Giulio; Sartelli, Massimo; Cardinali, Luca; Tranà, Cristian; Bracci, Raffaella; Gesuita, Rosaria; Marmorale, Cristina

    2015-01-01

    L’avvento dell’Imatinib mesilato (glivec) ha rivoluzionato la terapia dei GIST, apportando un aumento della sopravvivenza libera da malattia dopo resezione chirurgica completa di un GIST a localizzazione primitiva (RFS: Recurrence Free Survival). La definizione di un sistema prognostico accurato è fondamentale per decidere quali pazienti sottoporre a tale trattamento. In letteratura, esistono attualmente vari sistemi prognostici di riferimento in grado di predire la probabilità di recidiva, tra cui: NIH-FLETCHER, AFIP-MIETTINEN standard e modificato. A questi che sono i più diffusamente utilizzati, di recente si sono aggiunti altri metodi che utilizzano modelli matematici o no, come il Nomogramma del MSKCC, Nomogramma di Rossi ed il Joensuu high hotline Degjun. Nonostante tutti questi tentativi la storia naturale dei GIST rimane ancora non completamente nota e controversa e non è ancora possibile predire le recidive con una accuratezza assoluta. Lo scopo del nostro studio è stato quello di trovare quale sistema è più accurato e pratico per essere utilizzato nella nostra pratica clinica. Particolare attenzione è stata posta al Nomogamma del MSKCC, che è stato pertanto confrontato con i NIH-Fletcher ed AFIPMiettinen. Sono stati analizzati retrospettivamente i dati riguardanti 37 GIST operati presso il nostro istituto dal 2002 al 2012 e da questi sono stati selezionati 27 GIST a localizzazione primitiva, completamente resecati c non trattati con l’imatinib ne prima ne dopo l’intervento, sui quali è stato eseguito il confronto. Le conclusioni sono state che il nomogramma MSKCC è un metodo prognostico pratico, sicuro e valido, probabilmente più del NIH e AFIP e può essere utilizzato nella pratica clinica per predire il rischio di recidiva, specialmente nella pianificazione della strategia terapeutica, anche se non è un metodo ottimale per calcolare il tempo di sopravvivenza libera da recidiva. Il limite del Nomogramma del MSKCC sta nel valutare il

  15. Thyroid nodules in acromegaly: The role of elastography.

    PubMed

    Andrioli, M; Scacchi, M; Carzaniga, C; Vitale, G; Moro, M; Poggi, L; Fatti, L M; Cavagnini, F

    2010-09-01

    Sommario INTRODUZIONE: L’elastosonografia (US-E) è un utile strumento per la diagnosi del carcinoma tiroideo. Se nell’acromegalia lo struma multinodulare ha un’elevata prevalenza, ancora non vi è accordo sulla possibilità di un’aumentata prevalenza delle neoplasie maligne tiroidee. Obiettivi dello studio sono stati: a) valutare i noduli tiroidei nell’acromegalia con l’US-E; b) stabilire l’accuratezza di questa tecnica nel fornire informazioni sulla loro natura, usando l’esame citologico come parametro di riferimento. MATERIALI E METODI: L’US-E è stata eseguita in 25 pazienti acromegalici (7 guariti dalla chirurgia ipofisaria, 8 controllati dalla terapia medica, 10 con patologia attiva) che presentavano almeno un nodulo solido. Un totale di 90 noduli sono stati classificati secondo un punteggio elastosonografico (ES) in quattro classi di durezza: ES1 e ES2 per i noduli più elastici, ES3 e ES4 per quelli più duri. L’agoaspirato (FNAC) è stato effettuato nel 78.6% dei noduli ES 4 e nel 54,1% dei noduli ES 3. RISULTATI: Dei 90 noduli, 14 (15,5%) mostravano un ES 1, 25 (27,7%) un ES 2, 37 (41,3%) un ES 3 e 14 (15,5%) un ES 4. La prevalenza di noduli duri nei pazienti con acromegalia attiva (68,9%) era maggiore di quella osservata nei pazienti guariti (44,4%) e nei pazienti controllati (52,5%). Nell’intera popolazione di acromegalici la prevalenza di noduli duri (56,7%) era maggiore di quella riportata dalla letteratura nei pazienti non acromegalici con struma multinodulare (33,7%). Tutti i noduli sottoposti a FNAC sono risultati negativi per cellule tumorali maligne o per sospetta malignità. DISCUSSIONE: Questo studio ha dimostrato un’elevata prevalenza di noduli duri nell’acromegalia, soprattutto nei pazienti con patologia attiva. Tale prevalenza è maggiore di quella riportata in letteratura nei pazienti non acromegalici con patologia nodulare tiroidea. Questi noduli, tuttavia, non sono risultati maligni all’esame citologico e

  16. Assessment of photographs from wildlife monitoring cameras in Drakes Estero, Point Reyes National Seashore, California

    USGS Publications Warehouse

    Lellis, William A.; Blakeslee, Carrie J.; Allen, Laurie K.; Molnia, Bruce F.; Price, Susan D.; Bristol, R. Sky; Stewart, Brent

    2012-01-01

    Between 2007 and 2010, National Park Service (NPS) staff at the Point Reyes National Seashore, California, collected over 300,000 photographic images of Drakes Estero from remotely operated wildlife monitoring cameras. The purpose of the systems was to obtain photographic data to help understand possible relationships between anthropogenic activities and Pacific harbor seal (Phoca vitulina richardsi) behavior and distribution. The value of the NPS photographs for use in assessing the frequency and impacts of seal disturbance and displacement in Drakes Estero has been debated. In September 2011, the NPS determined that the photographs did not provide meaningful information for development of a Draft Environmental Impact Statement (DEIS) for the Drakes Bay Oyster Company Special Use Permit. Limitations of the photographs included lack of study design, poor photographic quality, inadequate field of view, incomplete estuary coverage, camera obstructions, and weather limitations. The Marine Mammal Commission (MMC) reviewed the scientific data underpinning the Drakes Bay Oyster Company DEIS in November 2011 and recommended further analysis of the NPS photographs for use in characterizing rates and consequences of seal disturbance (Marine Mammal Commission, 2011). In response to that recommendation, the NPS asked the U.S. Geological Survey (USGS) to conduct an independent review of the photographs and render an opinion on the utility of the remote camera data for informing the environmental impact analyses included in the DEIS. In consultation with the NPS, we selected the 2008 photographic dataset for detailed evaluation because it covers a full harbor seal breeding season (March 1 to June 30), provides two fields of view (two cameras were deployed), and represents a time period when cameras were most consistently deployed and maintained. The NPS requested that the photographs be evaluated in absence of other data or information pertaining to seal and human activity in

  17. Non-mycotic anastomotic pseudoaneurysm of renal allograft artery. Case Report.

    PubMed

    Ardita, Vincenzo; Veroux, Massimiliano; Zerbo, Domenico; D'Arrigo, Giuseppe; Caglià, Pietro; Veroux, Pierfrancesco

    2016-06-20

    Le complicanze vascolari dopo il trapianto renale non sono comuni, e nella maggior parte dei casi si presentano nel periodo post-trapianto precoce. Gli pseudoaneurismi arteriosi coinvolgono l’anastomosi arteriosa del rene trapiantato e nella maggior parte dei casi riconoscono una eziologia micotica. Una donna di 62 anni, che è stata sottoposta otto mesi prima ad un trapianto renale, presentava un vago dolore in fossa iliaca destra. L’ecografia del rene trapiantato dimostrava la presenza di un’area ipoecogena in corrispondenza dell’ilo renale, che all’ecocolordoppler appariva riccamente vascolarizzata. La tomografia computerizzata confermava la diagnosi di pseudo-aneurisma anastomotico di 33 mm di diametro, coinvolgente l’arteria del rene trapiantato. La paziente è stata dunque sottoposta a intervento chirurgico di aneurismectomia, con successivo bypass fra arteria renale del rene trapiantato e arteria iliaca interna. La continuità arteriosa iliaca è stata dunque ristabilita attraverso un by-pass iliaco-esterno-femorale comune in vena safena invertita. L’ecocolordoppler intraoperatorio dimostrava la corretta perfusione del graft renale e la corretta pervietà del by-pass iliacofemorale. Il decorso post-operatorio è stato privo di complicanze significative, eccettuata una linforrea inguinale risolta spontaneamente in 22a giornata post-operatoria. Sei mesi dopo la procedura, la paziente è in ottime condizioni generali, con una funzionalità renale conservata e una corretta pervietà del by-pass iliacofemorale. Lo pseudo-aneurisma dell’arteria renale rappresenta una rara complicanza del trapianto renale. Nella maggior parte dei casi riconosce una eziologia micotica, spesso a causa di contaminazione diretta del graft durante le procedure di prelievo o conservazione dell’organo. Il trattamento è molto complesso, e in molti casi richiede l’espianto del graft. Tuttavia, in alcuni casi selezionati, è possibile eseguire il trattamento dell

  18. Malignant transformation in non-recurrent peritoneal cystic mesothelioma Our experience and review of the literature.

    PubMed

    Santangelo, Giuseppe; Accardo, Marina; De Vita, Ferdinando; Del Giudice, Santolo; Gallucci, Federica; Fabozzi, Alessio; De Falco, Massimo

    2016-01-29

    Il mesotelioma peritoneale cistico è un tumore raro. Si tratta di un tumore benigno, che tuttavia va incontro a recidive locali post-chirurgiche in oltre il 50% dei casi. È proprio a seguito di recidive ricorrenti che si possono determinare trasformazioni maligne di questa neoplasia, come descritto in Letteratura. Nel Giugno del 2004 un paziente di 73 anni è giunto presso la nostra struttura con una tumefazione addominale causa di dolore gravativo: si trattava di una massa di 16 cm, la cui struttura, agli esami strumentali (ecografia, TC con m.d.c. e RMN), appariva pluricistica. Attraverso una laparotomia mediana si è provveduto alla sua rimozione e il paziente è stato dimesso in VIII giornata post-operatoria senza complicanze. L’esame istologico, corredato da studio immunoistochimico e di microscopia elettronica, ha consentito di porre diagnosi di mesotelioma peritoneale pluricistico in trasformazione maligna. D’accordo con gli oncologi, in considerazione della scarsa efficacia dei trattamenti adiuvanti e della scarsità dei dati riportati in Letteratura sull’argomento, si è deciso di sottoporre il paziente unicamente ad uno stretto follow-up, con esecuzione di ecografia addominale ogni sei mesi e TC addominale ogni anno. Ad oggi, dieci anni dopo il trattamento, il paziente, di 83 anni, gode di un discreto stato di salute e non si sono verificate riprese o recidive di malattia, né locali, né a distanza. Oltre al fatto di essere risultato maligno alla sua prima manifestazione e non dopo ripetute recidive, il caso presenta altre particolarità: il mesotelioma peritoneale cistico, infatti, solitamente colpisce soggetti di sesso femminile (con un rapporto F:M di 4,5:1) ad un’età media di 60 anni, mentre il caso descritto riguarda un soggetto di sesso maschile di 73 anni. La nostra osservazione dimostra la possibilità che il mesotelioma peritoneale vada incontro a trasformazioni maligne già alla sua prima manifestazione e non esclusivamente dopo

  19. Long-term adverse effects on dentition in children with poor-risk neuroblastoma treated with high-dose chemotherapy and autologous stem cell transplantation with or without total body irradiation.

    PubMed

    Hölttä, P; Alaluusua, S; Saarinen-Pihkala, U M; Wolf, J; Nyström, M; Hovi, L

    2002-01-01

    Chemo- and radiotherapy may have injurious effects on developing teeth. In this long-term follow-up study among poor-risk neuroblastoma (NBL) survivors our aims were: (1) to assess both the type and extent of the side-effects of the anticancer treatment on tooth development; and (2) to develop an index for expressing total damage to the permanent dentition. We studied the dental development from panoramic radiographs (PRG) of 18 long-term survivors treated under the age of 6 years with high-dose (HD) chemotherapy and autologous stem cell transplantation (ASCT) for poor-risk NBL. The myeloablative therapy was either HD chemotherapy and fractionated total body irradiation (TBI) of 10-12 Gy (TBI group, n = 10) or HD chemotherapy only (non-TBI group, n = 8). A defect index (DeI) was developed to describe the damage to the permanent dentition. The DeI was also tested in 18 healthy adolescents. All NBL patients had disturbances in dental development including short roots, arrested root development, microdontia and tooth aplasia. After TBI, 9/10 patients had very severe root defects, in contrast to none in the non-TBI group. All children in the TBI group had 2-12 (mean 6.6) missing permanent teeth, while 2/5 in the non-TBI group (3/8 excluded due to young age) had two and four missing permanent teeth, respectively. Microdontia was found at equal frequency in both groups. The mean value of the DeI was 70.0 (range 28-117) in the TBI group, 15.2 (range 4-34) in the non-TBI group (P<0.001, Mann-Whitney U test) and 1.8 (range 0-15) in healthy adolescents. Disturbances in dental development may compromise occlusal function in poor-risk NBL patients after ASCT, especially when TBI is included in the conditioning regimen. Long-term dental follow-up and rehabilitation is required.

  20. OBESITY PHENOTYPES IN URBAN MIDDLE-CLASS COHORTS; THE PRIT-LINDAVISTA MERGING EVIDENCE IN MEXICO: THE OPUS PRIME STUDY.

    PubMed

    Fanghänel-Salmón, Guillermo; Gutiérrez-Salmeán, Gabriela; Samaniego, Virginia; Meaney, Alejandra; Sánchez-Reyes, Leticia; Navarrete, Ulises; Alcocer, Luis; Olivares-Corichi, Ivonne; Najera, Nayeli; Ceballos, Guillermo; Meaney, Eduardo

    2015-07-01

    Antecedentes y metas: aun cuando el sobrepeso y la obesidad (S/O) son enfermedades reconocidas, hay un reclamo por la existencia de un fenotipo llamado “obeso sano”. Pocos estudios han explorado la presencia de diferentes fenotipos metabólicos en los rangos del índice de masa corporal (IMC) y su asociación con riesgo cardiovascular. Métodos: se determinaron fenotipos de acuerdo al IMC y a la presencia de marcadores del síndrome metabólico (SM) (circunferencia abdominal, presión sanguínea, glucemia en ayunas y perfil de lípidos). El riesgo cardiovascular fue estimado con los índices aterogénicos: colesterol total/HDL-c, LDL-c/HDL-c y triglicéridos(TG)/HDL-c. Resultados: en 8.405 adultos mexicanos, 36% delgados, 43% con sobrepeso y 21% obesos, se identificaron 9 fenotipos. Por cada categoría de peso se encontraron sujetos con metabolismo normal (ningún factor de SM), intermedios (≤ 2) y dismetabólicos (≥ 3). Solo el 10.8% de los sujetos con S/O tuvieron metabolismo normal y el 5.8% de los sujetos delgados fueron dismetabólicos. El riesgo aterogénico fue mayor en los sujetos obesos dismetabólicos. El riesgo fue alto entre todos los sujetos dismetabólicos independientemente del peso. El índice TG/ HDL-c mostró las mismas tendencias. Conclusiones: el riesgo cardiometabólico incrementado deriva de la alta prevalencia de S/O. Una gran proporción de sujetos no obesos tiene dismetabolismo intermedio. Una predisposición genética a la obesidad, la resistencia a la insulina, la diabetes y la dislipidémia en la población mexicana, junto con un estilo de vida no saludable da como consecuencia una epidemia catastrófica de diabetes y enfermedades cardiovasculares.

  1. Effect of alpha lipoic acid on the blood cell count and iron kinetics in hypertensive patients.

    PubMed

    Mendes, Paula Renata Florêncio; Félix, Danielle dos Santos; Silva, Paulo César Dantas da; Pereira, Guêdijany Henrique; Simões, Mônica Oliveira da Silva

    2014-11-03

    Introducción: El Ácido -Lipóico (ALA) ha sido utilizado como recurso terapéutico para reducir daño oxidativo en la Hipertensión Arterial Sistémica (HAS), pero aún no existen estudios in vivo que reporten sobre su mecanismo de acción en el metabolismo del hierro. Objetivo: Evaluar el efecto antioxidante del ácido Alfa- Lipóico sobre el hemograma y metabolismo del hierro en individuos hipertensos con o sin anemia. Métodos: Estudio clínico doble-ciego, randomizado y controlado con placebo. La muestra fue constituida por 60 individuos hipertensos, distribuidos aleatoriamente en grupo tratamiento (n = 32), que recibió 600 mg/día del ALA por doce semanas y grupo control (n = 28), que recibió el placebo por el mismo período. Fueron analizados antes y después de la intervención, los parámetros del hemograma, Hierro Sérico, Ferritina, Capacidad Latente de Enlace del hierro, Capacidad Total de Enlace del Hierro, Índice de Saturación de la Transferrina (ISI) y Transferrina. Para evaluar las alteraciones entre los grupos, se utilizó el teste t de Student y el análisis de varianza ANOVA, adoptándose el nivel de significación de 5%. Resultados: Después de la intervención, el suplemento con el ALA demostró una asociación estadísticamente significativa (p < 0,05) con la reducción de los leucocitos totales, aumento del número de neutrófilos y reducciones en los niveles de Hierro Sérico e ISI. Conclusión: La administración oral del ALA como un adyuvante terapéutico, altera la respuesta hematológica del leucograma y reduce la absorción del hierro. Cabe senãlar que el mecanismo de quelación de metales por el ácido lipoico puede ser responsable de estos cambios y, en consecuencia, podría desencadenar una condicion de anemia ferropénica en individuos hipertensos.

  2. [Assessment of lipid profiles and bone mineral density in renal transplant patients].

    PubMed

    Fernández Castillo, Rafael; Fernández Gallegos, Ruth; Peña Amaro, María Pilar; Esteban de la Rosa, Rafael José

    2015-06-01

    Introducción: las alteraciones del metabolismo lipídico y del metabolismo mineral óseo son trastornos frecuentes entre los pacientes trasplantados renales, lo que contribuye a la aparación de enfermedades matabólicas y cardiovasculares que ponen en peligro la integridad del injerto. Objetivo: describir y observar la evolución de las alteraciones de la densidad mineral ósea (DMO) y las alteraciones lipídicas en una población de pacientes trasplantados renales. Material y método: en este trabajo se ha seguido a 119 pacientes de ambos sexos trasplantados renales, a los cuales se les realizaron mediciones pretrasplante y postrasplante durante cinco años de parámetros bioquímicos, mediciones antropométricas y de la densidad mineral ósea en columna lumbar, fémur y radio-cubital. Resultados: durante los cinco años tras el trasplante se produce un importante aumento de parámetros bioquímicos, IMC, dislipemia, diabetes e hipertensión arterial. A los seis meses existe un alto porcentaje de pacientes con DMO patológica, aumentando un 4,1% al año del trasplante. Conclusiones: tras el trasplante se produce un gran incremento de la hiperlipidemia que se asocia con un patrón característico de alteración de lípidos con elevación del colesterol total, lipoproteínas de baja densidad, lipoproteínas de alta densidad, así como el consiguiente aumento de los triglicéridos, a pesar del tratamiento con estatinas, lo que conlleva un aumento en los factores de riego de padecer diabetes, hipertension arterial y enfermedades cardiovasculares; además se produce una pérdida de masa ósea, lo que conlleva un alto riesgo de sufrir fracturas graves, poniendo en peligro el injerto renal y la calidad de vida del paciente.

  3. Glycemic and lipid metabolic disorders in diabetic and non-diabetic patients bmi < 35 or > 35 before gastric bypass.

    PubMed

    Garcia-Caballero, Manuel; Reyes-Ortiz, Alexander; Martínez-Moreno, José Manuel; Toval-Mata, José Antonio

    2014-05-01

    Introducción: La obesidad y la diabetes son enfermedades de alta prevalencia a nivel mundial. Actualmente no existe un tratamiento médico eficaz para combatir el aumento de peso. La obesidad es precursora de enfermedades tales como la diabetes o el síndrome metabólico. Es necesario saber si el aumento de peso tiene efectos acumulativos sobre el metabolismo de la glucemia y los lípidos como precursores de complicaciones o comorbilidades. Pacientes y métodos: Se estudiaron 131 pacientes (78 no diabéticos y 53 diabéticos), 37 IMC ≤35 (3 IMC < 25, 18 IMC 25-29,9, 16 IMC 30-34,9) y 94 IMC ≥35 (81 IMC 35- 49,9 y 13 de IMC ≥50). Se analizó el IMC, el género, la diabetes y su tiempo de evolución. El perfil lipídico, glucosa, HbA1c y el péptido C fueron evaluados después de un ayuno de 12 horas. Resultados: Los pacientes diabéticos y diabesos mostraron niveles altos de triglicéridos. Los pacientes no diabéticos tienen alteración de la glucosa (58% IMC 35). El 20% de los no diabéticos IMC 35 tenían niveles altos. El 5% de los diabéticos IMC < 35 tenía bajos niveles de péptido C y 36% de IMC > 35 tenían niveles altos. HbA1c fue mayor en 40% de pacientes no diabéticos IMC < 35 frente al 13% de IMC > 35. Conclusiones: La glucosa y los triglicéridos aumentan con la edad y los años de evolución de la DMT2. La edad de ≥51 años y los hombres son los más afectados. El aumento de peso tiene efecto acumulativo alterando el metabolismo favoreciendo la aparición de la diabetes y sus comorbilidades. A pesar de tener un tratamiento de control intensivo de la diabetes, esta continúa con sus efectos nocivos sobre los pacientes a través de los años.

  4. EL PROTEOMA DEL TEJIDO ADIPOSO SUBCUTÁNEO MUESTRA HETEROGENEIDAD ANATÓMICA

    PubMed Central

    Martos-Moreno, G.A.; Sackmann-Sala, L.; Berryman, D.E.; Blome, D.W.; Argente, J.; Kopchick, y J.J.

    2015-01-01

    Introducción El tejido adiposo blanco (TAB) subcutáneo (Sc) humano podría variar dependiendo de su localización anatómica, con diferencias en su perfil proteómico. Pacientes y métodos Se obtuvieron aspirados de TAB-Sc de seis mujeres con IMC >25 kg/m2, sometidas a liposucción. Dicho TAB-Sc se obtuvo de seis localizaciones anatómicas: abdominal superior e inferior, muslo, dorsal, flanco y cadera, analizándose su perfil proteómico mediante electroforesis bidimensional. En muslo y abdomen superior se compararon, además, las muestras obtenidas de las dos capas del TAB-Sc (profunda y superficial). Resultados Se detectaron 21 proteínas que mostraban una intensidad de expresión diferente entre las seis localizaciones anatómicas y 14 entre las capas superficial y profunda de una misma región. Entre las proteínas identificadas se incluyen: vimentina (proteína estructural); proteínas “heat-shock” (HSPs), superóxido-dismutasa, (estrés/chaperoninas); proteína fijadora de ácidos grasos 4 (FABP-4) y alfa-enolasa (metabolismo lipídico y de los hidratos de carbono, respectivamente) y ATP-sintetasa (producción de energía). Entre las regiones estudiadas, el TAB-Sc dorsal mostraba un perfil proteómico particular, con menor expresión de proteínas implicadas en la producción de energía y metabolismo (ATP-sintetasa, alfa-enolasa, HSPs y FABP-4) que el resto de regiones. Conclusiones Los niveles de expresión de diversas proteínas en el TAB-Sc humano no son homogéneos, difiriendo entre localizaciones anatómicas. Esto sugiere la existencia de diferencias funcionales en el TAB-Sc de acuerdo con su localización anatómica, lo que debe considerarse antes de asumir la extrapolación de los datos derivados del TAB-Sc de una determinada localización al de otras partes de la anatomía. PMID:23228439

  5. Safety in the hypertriglyceridemia treatment with N-3 polyunsaturated fatty acids on glucose metabolism in subjects with type 2 diabetes mellitus.

    PubMed

    Reis, Caio Eduardo Gonçalves; Landim, Karla Câmara; Nunes, Aline Costa Santos; Dullius, Jane

    2014-10-06

    Introducción: Diabetes mellitus tipo 2 aumenta el riesgo de hipertrigliceridemia y es un factor de riesgo independiente para las enfermedades cardiovasculares. La literatura actual revela efectos beneficiosos de n-3 ácidos grasos poliinsaturados (n-3 AGPI) en el tratamiento de la hipertrigliceridemia, sin embargo, la seguridad de este tratamento en los sujetos diabéticos tipo 2 es discutible. Esta revisión de la literatura discute la seguridad del n-3 PUFA la suplementación sobre el metabolismo de la glucosa en el tratamiento de la hipertrigliceridemia en pacientes con diabetes mellitus tipo 2. Métodos: Se ha realizado una revisión de la literatura en la base de datos MEDLINE y EMBASE del los ensayos clínicos publicados con fecha posterior al 1990 hasta Junio de 2014 sobre los efectos de la ingesta / suplementos del n-3 AGPI en el tratamiento de la hipertrigliceridemia en pacientes con diabetes mellitus tipo 2. Resultados y Discusión: Catorce estudios clínicos (n = 2105) se incluyeron en esta revisión. Del estudios informaron una reducción en los niveles de triglicéridos entre 12 a 34% en interior del grupo comparación y de 15 a 36% en entre grupos análisis. Cuatro estudios mostraron un aumento significativo en el LDL-c (6-18%) y otros cuatro en los niveles de HDL-c (4 - 15%). No se encontraron cambios significativos en el colesterol total, VLDL-c, la glucosa, HbA1c y el índice de sensibilidad a la insulina. Conclusión: El n-3 AGPI suplementación lleva una mejora en los niveles de triglicéridos y no arrojaron deterioro en el metabolismo de la glucosa en pacientes con hipertrigliceridemia con diabetes mellitus tipo 2 siendo una opción segura para el tratamiento de la población diabética.

  6. [Human abnormalities--their importance in the world view during antiquity and the early Middle Ages].

    PubMed

    Neumann, J N

    1992-01-01

    In consideration of the experience that also in our present day society the development of a handicapped baby is understood by some as the visible result of a morally guilty behaviour of the parents, the present study raises the question, whether the identification of physical appearance and moral attitude has been in a certain historical epoch the preferred approach in science for understanding the origin of human malformations. After the treatment of the teratological theories in greek medicine and aristotelian natural philosophy the question of the origin of human malformation is examined in Pliny's "Historia naturalis" and Augustine's "De civitate dei". A comparison between the theories presented shows that the moral interpretation of human malformation is an inevitable consequence of the augustinian theological thinking.

  7. A Roman correspondence: George Ent and Cassiano dal Pozzo, 1637-55.

    PubMed

    Cook, Alan

    2005-01-22

    George Ent (FRS 1663), a distinguish physician, was in Rome in 1636, visited the notable collector Cassiano dal Pozzo and saw his Paper Museum. After he returned to London he carried on a correspondence with Cassiano in letters of more than ordinary interest. Cassiano had sent Ent specimens of fossil wood and a table made from fossil wood. They had come from the estates at Acquasparta belonging to Prince Federico Cesi, the founder of the Accademia dei Lincie. The specimens and the table were shown to early meetings of The Royal Society and had a significant part in the developing debate on the origin of fossils. The letters also record exchanges of books between London and Rome. Among medical matters there is news of William Harvey and his works.

  8. [Hildegard von Bingen: physician--mystic--poet].

    PubMed

    Schipperges, H

    1991-12-17

    Out of the multifaceted visionary writing of St. Hildegard from Bingen (1098-1179) three aspects are selected and commented on: 1. The cosmologically oriented art of healing showing man in its original state (constitutio) its actual condition (destitutio) and the expected healthy final state (restitutio); 2. An universal vision oriented on mystic enligthment proposing the individual as creation (opus Dei), as partner (opus alterum per alterium) and as worker on nature (opus cum creatura); 3. The esthetic dimension of universal and human perception as expressed by Hildegards songs (carmina) which culminate in hymns on the "celestrial Jerusalem". We should consider, that these aspects--beyond their historic roots--indicate ways for healing and salvation of the integral individual.

  9. Instrumentation For Diffraction Enhanced Imaging Experiments At HASYLAB

    SciTech Connect

    Lohmann, M.; Dix, W.-R.; Metge, J.; Reime, B.

    2004-05-12

    The new X-ray radiography imaging technique, named diffraction enhanced imaging (DEI), enables almost scatter free absorption imaging, the production of the so-called refraction images of a sample. The images show improved contrast compared to standard imaging applications. At the HASYLAB wiggler beamline W2 at the 2nd-generation storage ring DORIS a 5cm wide beam with an adjustable energy between 10 and 70keV is available. A Si [111] pre-monochromator is used followed by the main monochromator using the (111) or the (333)-reflection. Visualization of fossils, detecting internal pearl structures, monitoring of bone and cartilage and documentation of implant healing in bone are application examples at HASYLAB.

  10. An integrated approach to safety-driven and ICT-enabled process reengineering: methodological advice and a case study.

    PubMed

    Langer, M; Castellari, R; Locatelli, P; Sini, E; Torresani, M; Facchini, R; Moser, R

    2014-01-01

    Patient safety is a central concern inside any healthcare environment. With the progress of Information and Communication Technologies (ICTs), new solutions have become available to support care and management processes. Analyzing process risks helps identifying areas of improvement and provides ICT-solutions design with indications on what portions of the process need primary interventions. Understanding the link between process reengineering, technology assessment of enabling technologies and risk management allows user acceptance and patient safety improvements. Fondazione IRCCS Istituto Nazionale dei Tumori (INT), offers a good example of process reengineering driven by the purpose of increasing patient safety, enabled by new technologies. A pillar of the evolution of ICT process support at INT is based on Radio Frequency Identification technologies, implemented to identify and trace items and people across processes. This paper will present an integrated approach, based on process reengineering methodologies and risk assessment studies, and methodological advice applied to a case of surgical kits management procedures.

  11. Chinese-English Aviation and Space Dictionary

    DTIC Science & Technology

    1973-04-01

    34illlg f+4e ’tu’ p’ irduze’l radiation 29 .n:;J.jg •,•,j e . , tn O, ind’c J un V,’- d i ag 303- . ~I; - - a 4 4 ftp.*-11%’ t1 ganying luopan j...i 4 counterbalancing mass 11 xiangdui shidu 4 1 (4 >5,¶ 53_ relative humidity 1.2 xiangdui shicha IIIA I O A"’: relative parallax 13 xiangdui sudu i-i...l’i rZ bainite 15 Beikelai yuliangji A4g. jBeis ag 6- Dei-shi shengtie r- t t- Ai Bessemer iron; Bessemer 17 ’_ pig iron bifen reserve; standby, spare

  12. An EEGLAB plugin to analyze individual EEG alpha rhythms using the "channel reactivity-based method".

    PubMed

    Goljahani, A; Bisiacchi, P; Sparacino, G

    2014-03-01

    A recent paper [1] proposed a new technique, termed the channel reactivity-based method (CRB), for characterizing EEG alpha rhythms using individual (IAFs) and channel (CAFs) alpha frequencies. These frequencies were obtained by identifying the frequencies at which the power of the alpha rhythms decreases. In the present study, we present a graphical interactive toolbox that can be plugged into the popular open source environment EEGLAB, making it easy to use CRB. In particular, we illustrate the major functionalities of the software and discuss the advantages of this toolbox for common EEG investigations. The CRB analysis plugin, along with extended documentation and the sample dataset utilized in this study, is freely available on the web at http://bio.dei.unipd.it/crb/.

  13. Berengario da Carpi.

    PubMed

    De Santo, N G; Bisaccia, C; De Santo, L S; De Santo, R M; Di Leo, V A; Papalia, T; Cirillo, M; Touwaide, A

    1999-01-01

    Berengario da Carpi was magister of anatomy and surgery at the University of Bologna from 1502 to 1527. Eustachio and Falloppia defined him as 'the restaurator of anatomy'. He was a great surgeon, anatomist and physician of illustrious patients including Lorenzo II dei Medici, Giovanni dalle Bande Nere, Galeazzo Pallavicini, Cardinal Colonna, and Alessandro Soderini. He had strong links to the intellectuals of his time (Forni, Bonamici, Manuzio, Pomponazzi) as well as with the Medici family. He was respected by the Popes Julius II, Leo X and Clement VII. His main contributions are the Isogogae Breves, De Fractura calvae sive cranei, and the illustrated Commentaria on the Anatomy of Mondino de Liucci, a textbook utilized for more than 200 years, which Berengario aimed to restore to its initial text. The Commentaria constitutes the material for the last part of this paper which concludes with a personal translation of some passages on 'The kidney', where the author gives poignant examples of experimental ingenuity.

  14. Maimonides’ Appreciation for Medicine

    PubMed Central

    Gesundheit, Benjamin

    2011-01-01

    Moses Maimonides, the illustrious medieval rabbi and philosopher, dedicated the last decade of his life primarily to medicine. His strong interest in medicine was an integral component of his religious-philosophical teachings and world view. In this paper various sources from his rabbinic writings are presented that explain Maimonides’ motivation regarding and deep appreciation for medicine: (A) The physician fulfills the basic biblical obligation to return lost objects to their owner, for with his knowledge and experience the physician can restore good health to his sick fellow human being; (B) medicine provides a unique opportunity to practice imitatio dei, as it reflects the religious duty to maintain a healthy life-style; (C) as an important natural science, medicine offers tools to recognize, love, and fear God. These three aspects address man’s relationship and obligation towards his fellow-man, himself and God. Biographical insights supported by additional sources from Maimonides’ writings are discussed. PMID:23908790

  15. Penetrating cardiac injuries. Two case reports.

    PubMed

    Castriconi, Maurizio; Festa, Patrizio; Bartone, Giovanni; Maglio, Mauro Domenico Natale; Vicenzo, Luciano; Papaleo, Domenico; Severino, Beatrice Ulloa; Clemente, Marco; Martino, Antonio

    2013-04-24

    Presentiamo in questo breve lavoro due casi di ferita penetrante cardiaca in giovani pazienti di sesso maschile trattati chirurgicamente presso il trauma center dell’A.O.R.N. A. Cardarelli di Napoli. La peculiarità di entrambi i casi, più che nel trattamento chirurgico, che segue i canoni prescritti dalla letteratura internazionale, è nel timing. Entrambi I giovani,infatti, hanno ricevuto le prime cure in ospedali periferici per poi essere trasferiti nel nostro centro, lasciando che le cure del caso fossero differite di ore rispetto a ciò che ci si auspica in certi casi. Nonostante ciò i pazienti superano brillantemente l’intervento e vengono dimessi senza sequele. Per completare la discussione dei casi presentiamo una revisione della letteratura a riguardo dal 1986 al 2012.

  16. Western Regional Final Supplemental Environmental Impact Statement: Rulemaking for Small Power Production and Cogeneration Facilities - Exemptions for Geothermal Facilities

    SciTech Connect

    Heinemann, Jack M.; Nalder, Nan; Berger, Glen

    1981-02-01

    Section 643 of the Energy Security Act of 1980 directed the Federal Energy Regulatory Commission to develop rules to further encourage geothermal development by Small Power Production Facilities. This rule amends rules previously established in Dockets No. RM79-54 and 55 under Section 201 and 210 of the Public Utility Regulatory Policies Act of 1978 (PURPA). The analysis shows that the rules are expected to stimulate the development of up to 1,200 MW of capacity for electrical generation from geothermal facilities by 1995--1,110 MW more than predicted in the original PURPA EIS. This Final Supplemental EIS to the DEIS, issued by FERC in June 1980, forecasts likely near term development and analyzes environmental effects anticipated to occur due to development of geothermal resources in the Western United States as a result of this additional rulemaking.

  17. The abolition of capital punishment: contributions from two nineteenth-century Italian psychiatrists.

    PubMed

    Peloso, Paolo Francesco; Dening, Tom

    2009-06-01

    Capital punishment was the source of lively debate in Italy, from unification in 1861 until 1888. The precedent for abolishing the death penalty had been set in Tuscany in 1786. This paper presents the arguments put forward by two eminent psychiatrists who opposed the death penalty, Carlo Livi and Andrea Verga. Livi set out his scientific case for abolition in two addresses given to the Accademia dei Fisiocritici in Siena in 1862. In 1889 Verga wrote a commentary on the Senate sitting and argued in favour of approving the Italian Penal Code. Verga agreed with Livi's arguments and disagreed with the School of Criminal Anthropology, led by Cesare Lombroso and Raffaele Garofalo, who were both in favour of capital punishment.

  18. Four Classical Methods for Determining Planetary Elliptic Elements: A Comparison

    NASA Astrophysics Data System (ADS)

    Celletti, Alessandra; Pinzari, Gabriella

    2005-09-01

    The discovery of the asteroid Ceres by Piazzi in 1801 motivated the development of a mathematical technique proposed by Gauss, (Theory of the Motion of the Heavenly Bodies Moving about the Sun in Conic Sections, 1963) which allows to recover the orbit of a celestial body starting from a minimum of three observations. Here we compare the method proposed by Gauss (Theory of the Motion of the Heavenly Bodies Moving about the Sun in Conic Sections, New York, 1963) with the techniques (based on three observations) developed by Laplace (Collected Works 10, 93 146, 1780) and by Mossotti (Memoria Postuma, 1866). We also consider another method developed by Mossotti (Nuova analisi del problema di determinare le orbite dei corpi celesti, 1816 1818), based on four observations. We provide a theoretical and numerical comparison among the different procedures. As an application, we consider the computation of the orbit of the asteroid Juno.

  19. Virtual unrolling and deciphering of Herculaneum papyri by X-ray phase-contrast tomography.

    PubMed

    Bukreeva, I; Mittone, A; Bravin, A; Festa, G; Alessandrelli, M; Coan, P; Formoso, V; Agostino, R G; Giocondo, M; Ciuchi, F; Fratini, M; Massimi, L; Lamarra, A; Andreani, C; Bartolino, R; Gigli, G; Ranocchia, G; Cedola, A

    2016-06-06

    A collection of more than 1800 carbonized papyri, discovered in the Roman 'Villa dei Papiri' at Herculaneum is the unique classical library survived from antiquity. These papyri were charred during 79 A.D. Vesuvius eruption, a circumstance which providentially preserved them until now. This magnificent collection contains an impressive amount of treatises by Greek philosophers and, especially, Philodemus of Gadara, an Epicurean thinker of 1st century BC. We read many portions of text hidden inside carbonized Herculaneum papyri using enhanced X-ray phase-contrast tomography non-destructive technique and a new set of numerical algorithms for 'virtual-unrolling'. Our success lies in revealing the largest portion of Greek text ever detected so far inside unopened scrolls, with unprecedented spatial resolution and contrast, all without damaging these precious historical manuscripts. Parts of text have been decoded and the 'voice' of the Epicurean philosopher Philodemus is brought back again after 2000 years from Herculaneum papyri.

  20. Maimonides' appreciation for medicine.

    PubMed

    Gesundheit, Benjamin

    2011-01-01

    Moses Maimonides, the illustrious medieval rabbi and philosopher, dedicated the last decade of his life primarily to medicine. His strong interest in medicine was an integral component of his religious-philosophical teachings and world view. In this paper various sources from his rabbinic writings are presented that explain Maimonides' motivation regarding and deep appreciation for medicine: (A) The physician fulfills the basic biblical obligation to return lost objects to their owner, for with his knowledge and experience the physician can restore good health to his sick fellow human being; (B) medicine provides a unique opportunity to practice imitatio dei, as it reflects the religious duty to maintain a healthy life-style; (C) as an important natural science, medicine offers tools to recognize, love, and fear God. These three aspects address man's relationship and obligation towards his fellow-man, himself and God. Biographical insights supported by additional sources from Maimonides' writings are discussed.

  1. Galactic cosmic ray flux in the mid of 1700 from 44Ti activity of Agen meteorite

    NASA Astrophysics Data System (ADS)

    Taricco, Carla; Sinha, Neeharika; Bhandari, Narendra; Colombetti, Paolo; Mancuso, Salvatore; Rubinetti, Sara; Barghini, Dario

    2016-04-01

    Cosmogenic isotopes produced by galactic cosmic rays (GCR) in meteorites offer the opportunity to reveal the heliospheric magnetic field modulation in the interplanetary space between heliocentric distances of 1 and 3 AU. We present the gamma-activity measurement of Agen meteorite, a H5 chondrite that fell on September 5, 1814 in Aquitaine, France. Its 44Ti activity reflects GCR flux integrated since the mid of 1700 to the time of fall and confirms the decreasing trend of GCR flux that we previously suggested on the basis of measurements of other meteorites which fell in the last 250 years as well as the centennial modulation of GCR due to the Gleissberg solar cycle This result was obtained thanks to the high-efficiency and selective configuration of the gamma-ray spectrometer (HPGe+NaI) operating at the underground Laboratory of Monte dei Cappuccini (OATo, INAF) in Torino, Italy.

  2. IL TRAPIANTO ORTOTOPICO DEL FEGATO

    PubMed Central

    STARZL, THOMAS E.

    2010-01-01

    E’ormai noto che esiste la possibilità rivoluzionaria di utilizzare il fegato per il trattamento della stadio terminale delle epatopatie. Nel gennaio 1980 si celebra il decimo anna di sopravvivenza con fegato trapiantato (la più lunga della letteratura) di un paziente da noi trattato. Si tratta di uno dei 12 malati sottoposti a trapianto e seguiti per più di 5 anni. La nota positiva di questa tipo di trattamento è rappresentata dall’eccellente tenore di vita che i pazienti conducono e dalla riabilitazione sociale e professionale. La nota negativa è data, invece, dal fatto che i buoni risultati non vengono raggiunti con regolarità e non possono essere previsti con esattezza. In questa breve rassegna considereremo la esperienza da noi fatta presso l’Università di Denver nel Colorado, mettendo in risalto le cause dell’elevata mortalità precoce e le prospettive future di questa mezzo terapeutico. PMID:21572898

  3. Data of low-dose phase-based X-ray imaging for in situ soft tissue engineering assessments

    PubMed Central

    Izadifar, Zohreh; Honaramooz, Ali; Wiebe, Sheldon; Belev, George; Chen, Xiongbiao; Chapman, Dean

    2016-01-01

    This article presents the data of using three phase-based X-ray imaging techniques to characterize biomaterial scaffold and soft tissues in situ, as reported in our study “Low-dose phase-based X-ray imaging techniques for in situ soft tissue engineering assessments” [1]. The examined parameters include the radiation dose, scan time, and image quality, which are all critical to longitudinal in situ live animal assessments. The data presented were obtained from three dimensional imaging of scaffolds in situ cartilage by means of synchrotron-based computed tomography-diffraction enhanced imaging (CT-DEI), analyzer based imaging (CT-ABI), and in-line phase contrast imaging (CT-PCI) at standard and low dose imaging modalities. PMID:26909381

  4. CORRIGENDUM: Atoms riding Rayleigh waves Atoms riding Rayleigh waves

    NASA Astrophysics Data System (ADS)

    Benedek, G.; Echenique, P. M.; Toennies, J. P.; Traeger, F.

    2010-09-01

    In the original paper the affiliation list is incorrect. The correct address list is as follows: G Benedek1, 5, P M Echenique1, 2, J P Toennies3 and F Traeger4 1 Donostia International Physics Center (DIPC), Paseo Manuel de Lardizábal 4, 20018 Donostia—San Sebastián, Spain 2 Departamento de Física de Materiales and CFM (CSIC-UPV/EHU), Universidad del País Vasco/Euskal Herriko Unibertsitatea, E-20018 San Sebastián/Donostia, Spain 3 Max Planck-Institut für Dynamik und Selbstorganisation, Bunsenstraße 10 D-37073 Göttingen, Germany 4 Fakultät für Chemie und Biochemie, Ruhr-Universität Bochum Universitätsstraße 150, 44801 Bochum, Germany 5 Permanent address: Dipartimento di Scienza dei Materiali, Universitá di Milano-Bicocca, Via Cozzi 53, 20125 Milano, Italy

  5. L'eliosismologia: onde sismiche per studiare l'interno del Sole

    NASA Astrophysics Data System (ADS)

    Di Mauro, M. P.

    2014-12-01

    Negli ultimi cinquanta anni siamo stati testimoni di una straordinaria rivoluzione della conoscenza e comprensione della nostra stella grazie alla nascita dell'Eliosismologia, lo studio delle oscillazioni solari. Analogamente a ciò che accade nella Terra durante i terremoti, anche l'interno del Sole è pervaso continuamente da onde sismiche che provocano piccole oscillazioni, ovvero deformazioni della fotosfera. Le oscillazioni sono la manifestazione di diversi processi che avvengono all'interno della struttura del Sole e le frequenze sismiche dei modi osservati e misurati sulla superficie sono legate direttamente ai parametri fisici degli strati interni attraversati dalle onde sismiche. Lo studio delle oscillazioni rappresenta, quindi, l'unico metodo diretto per studiare la struttura e la dinamica interna del Sole. In questo articolo verranno illustrate le caratteristiche generali delle oscillazioni solari e verranno presentati i risultati importanti e i progressi notevoli raggiunti grazie all'Eliosismologia.

  6. Northeast Corridor improvement project draft environmental impact statement/report for electrification of Northwest Corridor, New Haven, CT. to Boston, MA. Volume 3. Technical appendices. Final report, September 1992-September 1993

    SciTech Connect

    Not Available

    1993-09-01

    The impacts of extending electrification on the National Railroad Passenger Corporation's (Amtrak) Northeast Corridor (NEC) from New Haven, Connecticut to Boston, Massachusetts are of direct concern to the Federal Railroad Administration (FRA). To improve rail service and increase ridership between New York and Boston, Amtrak proposes the electrification of the NEC main line between New Haven, CT and Boston, MA using an overhead 2 x 25,000 volt - 60 hertz power system. The volume Number III contains the detailed technical studies that were performed in order to identify and evaluate the environmental impacts of the proposed project. Some of these studies have been included entirely in the Draft Environmental Impact Statements-draft (DEIS/R) (Volume 1). The technical evaluations performed were based upon regulatory requirements as well as substantive issues raised by individuals and public agencies as part of the public participation program.

  7. [Endemic goiter in Latium: environmental and genetic factors].

    PubMed

    Paggi, A

    1998-01-01

    Most studies on the pathogenesis of endemic goiter focus above all on iodine deficiency. In some endemic goiter areas (i.e. Nigeria) there is no evidence of iodine deficiency; therefore, we suggest the taking into account of various factors, both environmental and non-environmental. We report the results of two studies carried out in three different areas in Latium: one of them (Cerveteri, RM) could be classified as high prevalence of goiter area, while the two others (Roccasecca dei Volsci, LT and Castel San Pietro Romano, RM) are true endemic goiter areas. The role of environmental factors, radioactivity and electromagnetism, foodstuff, the hydrogeological and chemical composition of natural water and the importance of genetics are here discussed, assuming that the endemic goiter could have a multifactorial pathogenesis.

  8. Swiss regulations for controlling clinical trials.

    PubMed

    Zanini, G M

    1998-04-01

    Switzerland has recently issued regulations designed to control all trials with drugs in human subjects, namely the 'Regolamento dell'Ufficio Intercantonale per il controllo dei medicamenti in fase di studio clinico' (Intercantonal Regulations Controlling Drugs used in Clinical Trials), which have been operating since 1st January 1995. These new regulations are generally consistent with other international regulations and have introduced the concept of good clinical practice (GCP) into Switzerland. There are other regulations in Switzerland, such as Federal regulations on immunobiological products, special rules governing the administration of radiolabelled drugs to humans, drugs of abuse and medical devices. Any gap in the central regulations must be filled by cantonal regulations, where they exist. This is a comprehensive review of the regulations governing clinical trials in Switzerland, with special attention being devoted to trials with therapeutic compounds and to compatibility between Swiss and international procedures.

  9. Magnified x-ray phase imaging using asymmetric Bragg reflection: Experiment and theory

    SciTech Connect

    Modregger, Peter; Schaefer, Peter; Koehler, Rolf; Luebbert, Daniel

    2006-08-01

    X-ray imaging using asymmetric Bragg reflection in the hard x-ray regime opens the way to improve the spatial resolution limit below 1 {mu}m by magnifying the image before detection, simultaneously providing a strong phase contrast. A theoretical formalism of the imaging process is established. Based on this algorithm, numerical simulations are performed and demonstrate that both Fresnel propagation and Bragg diffraction contribute to contrast formation. The achievable resolution of this technique is investigated theoretically; the results obtained can be used to improve future experimental setups. Furthermore, the minimum detectable phase gradient is estimated, for comparison with other phase sensitive imaging techniques. Results from biological objects demonstrate that the technique is viable for imaging both in two and three dimensions. Refraction contrast images are extracted from experimental projection images by an algorithm similar to diffraction-enhanced imaging (DEI), and used to achieve three-dimensional tomographic reconstruction.

  10. [Oral lesions in Kaposi sarcoma: clinical and radiotherapeutic considerations].

    PubMed

    Barberis, M; Brenna Betti, N; Lauritano, D; Sangiani, L; Spadari, F; Villa, S

    1996-01-01

    The epidemic form of Kaposi's sarcoma is the most frequent tumor in sieropositive patients. Every part of the body including oral cavity is affected by these lesions. According to modern acknowledgement in treating oropharynge carcinoma, radiotherapy is used for management of oral Kaposi's sarcoma. This paper reports a study of 10 patients suffering from Kaposi's sarcoma correlated to AIDS (EKS) treated with radiotherapy and chemiotherapy, achieving good results, at the Istituto Nazionale per lo Studio e la Cura dei Tumori of Milan (Divisone di Radioterapia C) from 1988 to 1992. Treatment has been performed using linear accelerator (6 Mev) or Co 60 unity in order to reach the deepest layer of mucosa lesions. Radiotherapy schedule consisted of 150-200 cGy daily fractions given 5 times/week (w) for 4-5 w in split-course.

  11. Modelling digestive constraints in non-ruminant and ruminant foregut-fermenting mammals.

    PubMed

    Munn, Adam J; Streich, W Jürgen; Hummel, Jürgen; Clauss, Marcus

    2008-09-01

    It has been suggested that large foregut-fermenting marsupial herbivores, the kangaroos and their relatives, may be less constrained by food intake limitations as compared with ruminants, due mainly to differences in their digestive morphology and management of ingesta particles through the gut. In particular, as the quality of forage declines with increasing contents of plant fibre (cellulose, hemicelluloses and lignin; measured as neutral-detergent fibre, NDF), the tubiform foregut of kangaroos may allow these animals to maintain food intakes more so than ruminants like sheep, which appear to be limited by fibrous bulk filling the foregut and truncating further ingestion. Using available data on dry matter intake (DMI, g kg(-0.75) d(-1)), ingesta mean retention time (MRT, h), and apparent digestibility, we modelled digestible dry matter intake (DDMI) and digestible energy intake (DEI) by ruminant sheep (Ovis aries) and by the largest marsupial herbivore, the red kangaroo (Macropus rufus). Sheep achieved higher MRTs on similar DMIs, and hence sheep achieved higher DDMIs for any given level of DMI as compared with kangaroos. Interestingly, MRT declined in response to increasing DMI in a similar pattern for both species, and the association between DMI and plant NDF contents did not support the hypothesis that kangaroos are less affected by increasing fibre relative to sheep. However, when DEI was modelled according to DDMIs and dietary energy contents, we show that the kangaroos could meet their daily maintenance energy requirements (MER) at lower levels of DMI and on diets with higher fibre contents compared with sheep, due largely to the kangaroos' lower absolute maintenance and basal energy metabolisms compared with eutherians. These results suggest that differences in the metabolic set-point of different species can have profound effects on their nutritional niche, even when their digestive constraints are similar, as was the case for these ruminant and non

  12. Laparoscopic resection of tailgut cysts: the size is not the issue.

    PubMed

    Dalmonte, Giorgio; Tartamella, Francesco; Mita, Maria Teresa; De Sario, Giuseppina; Roncoroni, Luigi; Marchesi, Federico

    2016-11-03

    Gli amartomi cistici retrorettali (Tailgut cysts) sono rare lesioni dello spazio presacrale che avendo rischio intrinseco di trasformazione maligna e recidiva sono normalmente trattate mediante asportazione chirurgica anche nel caso in cui siano asintomatiche. Negli ultimi vent’anni si sta affermando il trattamento mediante accesso addominale laparoscopico per la sua migliore esposizione delle strutture della pelvi e la sua minore invasività. In questo caso clinico presentiamo il trattamento del più grande amartoma cistico retrorettale asportato laparoscopicamente fino ad ora riportato in letteratura. Essendo nella maggior parte dei casi asintomatici, la diagnosi degli amartomi cistici retrorettali è spesso incidentale durante una visita medica di routine. Nel successivo studio è particolarmente indicata la RM per orientare la scelta dell’approccio chirurgico data la sua maggiore risoluzione nei tessuti molli e nella determinazione dell’invasività locale. La trasformazione maligna di queste lesioni si stima possa avvenire nel 14,1% dei casi, per questo l’exeresi chirurgica è la terapia di scelta. Tra i differenti approcci la tecnica transaddominale laparoscopica, se eseguita da chirurghi esperti nella chirurgia pelvica laparoscopica, garantisce la migliore visualizzazione degli organi pelvici e una minore morbidità. A causa del rischio di rottura e insemenzamento l’approccio laparoscopico non dovrebbe essere utilizzato in caso di sospetta malignità della lesione cistica. Il nostro caso corrobora la validità del trattamento laparoscopico degli amartomi cistici retrorettali, anche quando possiedono dimensioni considerevoli. Lo studio preo-peratorio è quindi cruciale per determinare la possibile malignità della lesione ed eseguire in tal caso un approccio laparotomico.

  13. Sonographic examination of epiaortic vessels in patients with peripheral vertigo.

    PubMed

    Salvaggio, G; Gargano, R; Campisi, A; Cantisani, V; Ricci, P; Gallina, S; Midiri, M; Caruso, G

    2010-09-01

    Sommario INTRODUZIONE: Valutare l’utilità dell’eco-color Doppler (CDU) dei vasi epiaortici nei pazienti con vertigine periferica da causa sconosciuta. MATERAILI E METODI: Centocinquantasei pazienti (gruppo studio; 42 uomini e 114 donne; età media 61,86 ± 14,14) e 161 pazienti (gruppo controllo; 80 uomini e 81 donne; età media 62,31 ± 13,69) sono stati sottoposti a CDU dei vasi epiaortici. Sono stati valutati i seguenti parametri: presenza di placche ateromasiche a livello dell’arteria carotide (CA) comune e/o interna; spessore medio intimale (IMT) della CA comune; picco di velocità sistolica (PSV) e indice di resistenza (RI) a livello delle arterie vertebrali (VA).Sono stati utilizzati test parametrici (T-test) e non parametrici (Mann–Whitney U-test e Kolmogorov–Smirnov test). È stata eseguita un’analisi di regressione logistica per fornire un odds ratio indice di grandezza del rischio di vertigine. Sono state considerate variabili indipendenti (età, sesso), fattori di rischio vascolare (ipercolesterolemia, diabete, ipertensione) e variabili CDU (IMT, placche, PSV e RI). RISULTATI: Placche ed IMT > 1 mm sono stati trovati in 31 (19,8%) e 98 (62,8%) pazienti del gruppo di studio e in 43 (26,7%) e 125 (77,6%) pazienti del gruppo controllo. I test statistici, applicati a PSV e RI, non hanno dimostrato differenze significative (p-valore > 0,05). Alla regressione logistica le vertigini sono risultate associate ad età, sesso, ipercolesterolemia, diabete, ipertensione e IMT (p < 0,01), mentre placche, PSV ed RI non erano fattori significativi (p > 0,05). DISCUSSIONE: IMT è la sola variabile CDU significativamente associata alla vertigine, specialmente nelle classi di età inferiore (35-45 e 45-55) del gruppo studio.

  14. Meningococco B: controllo di due focolai epidemici mediante vaccinazione

    PubMed Central

    2014-01-01

    Riassunto La problematica di un efficace approccio vaccinale nei confronti del Meningococco B (MenB) è stata superata identificando con la metodica della "reverse vaccinology" alcuni antigeni capaci di indurre una risposta verso la maggior parte dei ceppi di MenB circolanti nel mondo. Il nuovo vaccino MenB a 4 componenti (4CMenB) è stato autorizzato in Europa, Australia e Canada, ed è entrato nei calendari di immunizzazione pediatrica internazionali: Australia, Canada, UK. In Italia, le prime regioni che hanno raccomandato la vaccinazione contro il MenB sono state Basilicata e Puglia. La gestione di epidemie/focolai epidemici richiede la messa in atto di una risposta rapida da parte delle autorità sanitarie nei confronti di una emergenza sanitaria ad elevato impatto, anche emotivo, sulla popolazione, come recentemente dimostrato in due università americane. Alla dichiarazione di focolaio epidemico in atto, in entrambi i contesti si è attivata una procedura per l'uso del vaccino 4CMenB non ancora autorizzato negli USA. È stato così possibile organizzare gli interventi di profilassi attiva nei due campus universitari, adottando il primo impiego su larga scala del nuovo vaccino 4CMenB e conseguendo, in tempi relativamente brevi, elevati tassi di copertura vaccinale. A fronte di circa 14000 studenti immunizzati con almeno una dose, non è stata segnalata alcuna problematica di eventi avversi conseguenti all'immunizzazione; ad oggi non si sono verificati casi nei soggetti che hanno ricevuto il vaccino. Come conseguenza dei due focolai descritti, è oggi in corso la valutazione da parte dell'FDA per l'estensione dell'uso del vaccino 4CMenB negli Stati Uniti negli adolescenti e giovani adulti. PMID:25916017

  15. [Atmospheric non-methane hydrocarbons near plants of crude oil first treatment].

    PubMed

    Bustaffa, Elisa; De Marinis Loiotile, Annamaria; Farella, Genoveffa; Petraccone, Stefania; De Gennaro, Gianluigi; Bianchi, Fabrizio

    2016-01-01

    La continua espansione delle attività di perforazione ai fini dell'estrazione petrolifera in prossimità di aree abitate ha fatto sì che negli ultimi anni l'attenzione si focalizzasse sull'impatto di questo processo fortemente industrializzato sulla salute pubblica. Le comunità che vivono nei dintorni di impianti di questo tipo devono, infatti, fronteggiare diversi problemi, quali l'inquinamento atmosferico e acustico, la contaminazione del suolo e delle acque sotterranee, il traffico dei camion da e verso il sito, incidenti e malfunzionamenti all'interno dell'impianto. In questo contesto, la valutazione del rischio per la salute è ostacolata dal fatto che l'esposizione alle sostanze chimiche presenti non può essere valutata in via definitiva, poiché non sempre si è a conoscenza di tutti i composti immessi nell'ambiente né delle loro concentrazioni, per non parlare del problema delle coesposizioni ad altri inquinanti. Nonostante l'oramai conclamato e vasto interesse generato da questo argomento, ad oggi esistono pochi studi basati su popolazioni riguardanti gli effetti sulla salute delle comunità che vivono in prossimità dei siti di perforazione ed estrazione; ciò genera la necessità di condurre campagne di monitoraggio mirate e studi epidemiologici che verifichino l'eventuale esistenza e natura di pattern di malattie associati a tali attività. La presente rassegna bibliografica individua, quindi, i principali inquinanti atmosferici presenti in prossimità di un impianto di primo trattamento del greggio e cerca di fornire un quadro generale delle loro potenziali sorgenti e caratteristiche.

  16. Plasma viscosity: a potential predictor of both medical treatment response and clinical stage of ulcerative colitis.

    PubMed

    Tolga, Yakar; Mansur, Cosar Arif; Savas, Gokturk Hu Seyin; Gulhan, Unler Kanat Ayse; Alper, Parlakgumus; Ilknur, Kozanoglu; Ender, Serin

    2016-01-01

    La colite ulcerosa (UC) è una delle maggiori forme di colonpatia infiammatoria cronica recidivante. La capacità di identificare tipo, gravità e sensibilità alla terapia su parametri di laboratorio è da tempo oggetto di ricerca degli studi clinici. Lo scopo di questo studio è quello di accertare la relazione tra la viscosità del plasma (PV), l’attività della malattia e la risposta al trattamento medico. Lo studio si è svolto su 105 pazienti con UC e 42 volontari sani. I prelievi di sangue sono stati utilizzati per valutare la viscosità del plasma (PV), la velocità di eritrosedimentazione (ESR), la proteina C-reattiva ultrasensibile (hs-CRP), il D-dimero e il fibrinogeno. I pazienti con UC sono stati raggruppati in relazione al grado di attività flogistica (cioè 59 attivi e 46 in remissione). La PV è risultata più elevata in quelli con UC attiva rispetto a quella dei soggetti in remissione o nei soggetti sani. È risultata significativamente più elevata sia nei casi di UC refrattaria al trattamento steroideo rispetto a quelli sensibili (p< 0.001), e nelle UC rafrattarie alla ciclosrporina rispetto a quelli sensibili (p= 0.003). Con l’aumento della PV nei pazienti affetti da UC sono risultati significativamente associati il punteggio del SCCAI (Increased Simple Clinical Colitis Activity Index), dell’EGS (Endoscopic Grading Scale) e del HAD (Histological Disease Activity (HAD). Si conclude che la PV è un marker utile per la previsione di sensibilità al trattamento sterorideo e con ciclosporina nei pazienti con UC attiva. Potrebbe essere rimpiazzata dalla ESR e dalla hs-CRP come misura della risposta in fase acuta in quanto sufficientemente sensibile. Questi risultati possono essere utili per l’identificazione dei pazienti con UC attiva da destinare alla colectomia.

  17. Bio-Engineering tissue and V.A.C. therapy: A new method for the treatment of extensive necrotizing infection in the diabetic foot.

    PubMed

    Armenio, Andrea; Cutrignelli, Daniela Anna; Nardulli, Maria Luisa; Maggio, Giulio; Memeo, Giuseppe; De Santis, Valerio; Giudice, Giuseppe; Ressa, Cosmo Maurizio

    2016-12-06

    La prevalenza mondiale del diabete nel 2000 è stata stimata essere del 2.8% con una previsione del 4.4% nel 2030. A causa della neuropatia e dei processi ischemici che ne derivano, i pazienti diabetici sono purtroppo predisposti all’insorgenza di infezioni a carico del piede con un rischio di amputazione molto elevato. A tal proposito, un trattamento rapido ed efficace del processo necrotizzante impedirebbe complicanze maggiori e la stessa amputazione. Il nostro studio consiste in un’analisi retrospettiva condotta su 20 pazienti atta a valutare l’efficacia del sostituto dermico autologo bioingegnerizzato (Hyalograft 3D Autograft) in associazione alla V.A.C (vacuum assisted closure) Therapy per il trattamento delle ulcere diabetiche, rispetto ai metodi sinora impiegati. I pazienti selezionati, a seconda del trattamento eseguito, sono stati suddivisi in due gruppi omogenei di dieci pazienti ciascuno. Il gruppo controllo è stato trattato con il metodo standard, ovvero con debridment chirurgico e innesti cutanei autologhi, mentre il gruppo studio è stato trattato con il metodo in analisi. La raccolta dei dati ha suggerito come l’impiego combinato del sostituto dermico bioingegnerizzato e della pressione negativa determini, rispetto al gruppo controllo, un aumento della percentuale di guarigione, una riduzione del tasso di recidiva di lesioni anche estese e una maggiore ripresa della deambulazione autonoma. In conclusione, la nostra analisi ha evidenziato un metodo sicuro, affidabile e competitivo per il trattamento di ampie lesioni necrotizzanti del piede diabetico. Anche se ulteriori valutazioni sono necessarie, crediamo fortemente che l’associazione del derma bioingegnerizzato e della pressione negativa possa condurre ad una rapida ed efficace guarigione delle ulcere, migliorando la qualità della vita del paziente diabetico.

  18. Metastasis of the gallbladder from the breast cancer.

    PubMed

    Fleres, Francesco; Rossitto, Maurizio; Foti, Agata; Macrì, Antonio; Cucinotta, Eugenio

    2014-12-29

    Le lesioni metastatiche della colecisti costituiscono una condizione clinica non frequente. Nella maggior parte dei casi si tratta di metastasi da melanoma, da tumore renale e da tumori della cervice. Lesioni metastatiche colecistiche da tumore primitivo della mammella sono descritte raramente in letteratura. In questa nota viene presentato il caso di una donna di 83 anni, sottoposta ad intervento chirurgico di colecistectomia videolaparoscopica (VL) per colelitiasi, con riscontro all’esame istologico del pezzo operatorio di una lesione di tipo metastatico Il carcinoma della mammella ed in particolare la varietà istologica duttale infiltrante si associa con elevata frequenza a metastasi loco-regionali e a distanza, quest’ultime a carico di ossa, fegato, polmone e SNC. Lesioni metastatiche a carico del tratto gastrointestinale, del peritoneo, del retroperitoneo e della pelvi possono essere causate soprattutto dal carcinoma lobulare invasivo, variante istologica meno frequente rispetto al tumore duttale rappresentando circa il 10% di tutti i carcinomi mammari. In questa nota è stata condotta una analisi dei dati della Letteratura sulle lesioni secondarie della colecisti da carcinoma della mammella che ha permesso di confermare la rarità di tale patologia descritta solamente in 18 pazienti: 12 di origine lobulare infiltrante, 1 di origine duttale e 2 misto duttale e lobulare infiltrante. La prognosi del carcinoma mammario metastatico è considerato incerto e spesso infausto. Clinicamente è difficile sospettare una localizzazione metastatica da carcinoma mammario primario nella colecisti, ma riteniamo che sia necessario conoscere bene questa possibilità di metastasi e da tenere a mente durante il follow-up di pazienti con cancro al seno. Sebbene la colecistectomia sia considerata come trattamento palliativo nelle pazienti con metastasi alla colecisti da carcinoma mammario, è consigliabile nei casi sintomatici.

  19. Abdominal compartment syndrome and open abdomen management with negative pressure devices.

    PubMed

    Surace, Alessandra; Ferrarese, Alessia; Marola, Silvia; Cumbo, Jacopo; Valentina, Gentile; Borello, Alessandro; Solej, Mario; Martino, Valter; Nano, Mario

    2015-01-01

    Per sindrome compartimentale addominale (SCA) si intende un incremento della pressione intra-addominale (PIA) a valori superiori a 20 mmHg, associato ad una ridotta perfusione e disfunzione d’organo. La mortalità della SCA è del 50%; la sua incidenza tra i pazienti in RIA è del 30-50%. Il trattamento chirurgico consiste sostanzialmente nella decompressione addominale con apertura dell’addome; attualmente la metodica più utilizzata per la gestione della SCA è la terapia a pressione negativa. Nel 2009 è stata realizzata una classificazione dell’addome aperto, che stratifica i pazienti in base alla cronologia naturale del miglioramento o del deterioramento clinico dei pazienti con addome aperto. Lo scopo del trattamento è mantenere l’addome aperto del paziente al livello più basso ed evitare la progressione ad un livello più complesso. Secondo quanto riportato in letteratura questa metodica consente un tasso di chiusura fasciale tra i 65 e il 100% dei casi, riduce i tassi di mortalità e i tempi di degenza nei reparti di terapia intensiva. La chiusura dell’addome può avvenire progressivamente (per ridurre il rischio di fascite) oppure mediante l’utilizzo di una protesi biologia spessa su cui viene posizionata una copertura in plastica e impostato il lavaggio nel sottocute: la parete addominale deve essere chiusa dopo 24 ore. Se non fosse possibile chiudere tutti gli strati della parete addominale, il tentativo deve riguardare almeno il peritoneo, per ridurre morbilità e mortalità.

  20. A wide-beam X-ray source suitable for diffraction enhanced imaging applications

    NASA Astrophysics Data System (ADS)

    Kim, Chang H.; Bourham, Mohamed A.; Michael Doster, J.

    2006-10-01

    Research in diffraction-enhanced imaging (DEI), using a synchrotron source with an X-ray flux of 1.4×10 12 ph/mm 2/s, has shown strong potential in obtaining high-resolution images as compared to conventional radiographs. This research investigates the feasibility of developing a large area circular X-ray source with fluxes comparable to a synchrotron source. The source should be capable of integration into a compact system with peak powers not to exceed 200 kW to be feasible for use in a major medical facility, industrial complex or screening facility (such as cargo or airport). A computational study of a circular concentric filament wide-beam area X-ray source has been investigated in this research. The design features are based on generating electrons from three concentric circular filaments to provide an area electron flux, with a 60 kV accelerating potential and a beam current of up to 3 A. The X-ray target is a grounded stationary oxygen-free copper target with a layer of molybdenum. This target feature differs from standard rotating X-ray targets in conventional X-ray systems. Studies of electron trajectories and their distribution on the target were conducted using the SIMION 3D code. Heat loading and thermal management were studied using heat transfer modules from the coupled FEMLAB multi-physics and MATLAB codes. The Monte Carlo code MCNP 5 was used to obtain the X-ray flux and energy distribution for aluminum and beryllium windows. This computational study shows that this target configuration generates X-rays with photon flux comparable to synchrotron source and sufficient for DEI applications. The maximum target temperature rise is 1357 K after 70 s when cooling the back of the target to liquid nitrogen temperature using cold finger contact, and 325 K for an invaded target, in which liquid nitrogen circulates inside the target.

  1. The pedagogic evolution in Surgery: the University at the centre of a training which becomes territorialized The model of the region Marche.

    PubMed

    Patrizi, Andrea; Tranà, Cristian; Baldoni, Andrea; Coletta, Pietro; Marmorale, Cristina

    2014-01-01

    La formazione in Chirurgia è un tema di grande interesse in un’epoca di crisi, ma anche di grandi cambiamenti mossi dalla spinta della Comunità Europea di uniformare i Percorsi Formativi di tutti i suoi Stati Membri. I punti principali delle riforme attuate per uniformarci al contesto Comunitario, vertevano sulla riduzione dei tempi e sulla implementazione della multidisciplinarietà della formazione specialistica, con il rischio di adombrare quelli che sono i punti di forza del nostro Sistema Sanitario, tra cui l’alto livello assistenziale dei nostri ospedali territoriali. La Scuola di Specializzazione di Chirurgia Generale dell’UNIVPM da alcuni anni punta su un progetto che vede la Clinica Universitaria al Centro di una Formazione Specialistica che si sviluppa sempre più sul territorio, avvicinando il mondo Ospedaliero a quello Universitario. Questo nuovo modello organizzativo prevede una prima fase all’interno della Clinica Universitaria ed una seconda nella Rete Formativa, nella quale rientrano Centri a differente impatto specialistico, all’interno di Strutture Ospedaliere Italiane ed Estere, e la possibilità di poter collaborare con l’Organizzazione di Emergency. Per testare questa nuova organizzazione del Corso Specialistico, abbiamo preso in analisi l’attività chirurgica svolta dagli specializzandi del nostro Ateneo, che hanno terminato il loro percorso formativo in Chirurgia Generale a Marzo 2014, essendo loro i primi ad aver beneficiato di questo modello. L’attività operatoria è stata, per ciascuno, mediamente di 400 interventi da primo operatore (237-476) distribuiti in chirurgia maggiore 44 (13-80), media 172 (129-268) e minore 209 (70-378), rapportando i loro risultati con gli standard complessivi di addestramento professionalizzante previsti dallo Statuto Nazionale si osserva il buon rendimento di questo sistema, che vede i suoi punti di forza nell’EQUITA dell’offerta, in quanto standardizzabile; nel concetto di RETE

  2. Low-dose phase-based X-ray imaging techniques for in situ soft tissue engineering assessments.

    PubMed

    Izadifar, Zohreh; Honaramooz, Ali; Wiebe, Sheldon; Belev, George; Chen, Xiongbiao; Chapman, Dean

    2016-03-01

    In tissue engineering, non-invasive imaging of biomaterial scaffolds and tissues in living systems is essential to longitudinal animal studies for assessments without interrupting the repair process. Conventional X-ray imaging is inadequate for use in soft tissue engineering due to the limited absorption difference between the soft tissue and biomaterial scaffolds. X-ray phase-based imaging techniques that derive contrast from refraction or phase effects rather than absorption can provide the necessary contrast to see low-density biomaterial scaffolds and tissues in large living systems. This paper explores and compares three synchrotron phase-based X-ray imaging techniques-computed tomography (CT)-diffraction enhanced imaging (DEI), -analyzer based imaging (ABI), and -phase contrast imaging (PCI)-for visualization and characterization of low-density biomaterial scaffolds and tissues in situ for non-invasive soft tissue engineering assessments. Intact pig joints implanted with polycaprolactone scaffolds were used as the model to assess and compare the imaging techniques in terms of different qualitative and quantitative criteria. For long-term in vivo live animal imaging, different strategies for reducing the imaging radiation dose and scan time-reduced number of CT projections, region of interest, and low resolution imaging-were examined with the presented phase-based imaging techniques. The results demonstrated promising capabilities of the phase-based techniques for visualization of biomaterial scaffolds and soft tissues in situ. The low-dose imaging strategies were illustrated effective for reducing the radiation dose to levels appropriate for live animal imaging. The comparison among the imaging techniques suggested that CT-DEI has the highest efficiency in retaining image contrast at considerably low radiation doses.

  3. [Waiting time between acute event and rehabilitation: continuity of nursing care and rehabilitation. Analysis and suggestions for a Service of Protected Discharge].

    PubMed

    D'Ilio, Ilaria; Raimondi, Anna Maria; Radice, Laura; Di Mauro, Stefania

    2014-01-01

    INTRODUZIONE. In Italia negli ultimi anni l’aumento della sopravvivenza della popolazione ha comportato il cambiamento dello stato di salute, che vede l’incremento nella prevalenza delle patologie croniche (Osservatorio, 2011). L’ospedale, riservato alla fase acuta delle patologie, si integra necessariamente con le cure primarie. La continuità assume particolare rilevanza per la cura, assistenza e riabilitazione della persona assistita, così come l’appropriato utilizzo delle diverse tipologie di offerta socio sanitaria assistenziale e riabilitativa. OBIETTIVO. Al San Gerardo di Monza, nell’ambito della riabilitazione del paziente post-acuto, si analizza la fase che intercorre tra la dimissione prevista dall’ospedale e la data di accettazione presso gli istituti di riabilitazione. E’ possibile quantificare i tempi di attesa? L’ allocazione delle persone assistite è appropriata? Scopo dello studio osservazionale descrittivo è accertare la distribuzione dei giorni di attesa. Inoltre si ipotizza il ricorso all’Assistenza Domiciliare Integrata e a soluzioni innovative. Obiettivi sono la diminuzione delle giornate di degenza inappropriate e l’utilizzo delle risorse in modo congruo. RISULTATI. Delle 1083 persone in attesa di riabilitazione il 55% (652), a cui sono associate 4505 giornate “inappropriate”, è stato dimesso dall’ospedale oltre i tempi previsti. CONCLUSIONI. L’utilizzo dell’assistenza domiciliare, vantaggiosa per l’ospedale, può essere utilizzata solo per una minoranza di pazienti e in modo diseconomico. Per abbattere la totalità delle giornate, una soluzione innovativa può essere l’istituzione di posti letto a basso costo. E dato che la maggioranza dei casi sono solo ad alta complessità assistenziale ma a bassa intensità clinica potrebbero essere letti gestiti da infermieri.

  4. [Valutazione del carico gestionale in un centro diurno psichiatrico: gravosità e recovery style].

    PubMed

    Callegari, Camilla; Caselli, Ivano; Bertù, Lorenza; Berto, Emanuela; Vender, Simone

    2016-01-01

    RIASSUNTO. Scopo. Nella riabilitazione psichiatrica il piano di trattamento individuale può essere formulato a partire da strumenti che offrano una valutazione multidimensionale del paziente. Il lavoro si propone di analizzare il rapporto tra gravosità (distress degli operatori) e stile di recupero (integration e sealing over) dalla patologia psicotica. Ipotizzando che esso influenzi il carico gestionale, lo studio si pone l'ulteriore obiettivo di acquisire maggiori elementi che indirizzino la formulazione di piani terapeutico-riabilitativi più efficaci. Metodi. Lo studio è stato condotto presso un centro diurno psichiatrico, struttura semi-residenziale dei servizi psichiatrici del Sistema Sanitario Nazionale in Italia. 45 pazienti reclutati sono stati valutati mediante la Neuropsychiatric Inventory (NPI - versione italiana) e la Integration/Sealing Over Scale (ISOS - versione italiana), nell'arco di tre mesi (marzo-giugno 2014). Risultati. Nel campione esaminato è emerso che la disinibizione, l'irritabilità e l'apatia sono i sintomi che provocano maggiore distress negli operatori, in senso assoluto. Inoltre, i risultati indicano che depressione e ansia recano un grado maggiore di distress nei pazienti sealer. Discussione e conclusione. Gli aspetti della disinibizione, dell'irritabilità e dell'apatia sono risultati più gravosi per gli operatori in quanto richiedono maggiore coinvolgimento nella relazione terapeutica. Sintomi ansiosi e depressivi risultano più gravosi nel gruppo dei sealer, segnalando minore tenuta della negazione della psicosi. I dati osservati sembrano provare che conoscere, differenziare e approfondire i diversi aspetti dello stile di recupero di ciascun paziente consente di stimare l'impegno gestionale fin dalla presa in carico e di ridurre il distress e il rischio di burnout degli operatori.

  5. Simulated Driving Assessment (SDA) for Teen Drivers: Results from a Validation Study

    PubMed Central

    McDonald, Catherine C.; Kandadai, Venk; Loeb, Helen; Seacrist, Thomas S.; Lee, Yi-Ching; Winston, Zachary; Winston, Flaura K.

    2015-01-01

    Background Driver error and inadequate skill are common critical reasons for novice teen driver crashes, yet few validated, standardized assessments of teen driving skills exist. The purpose of this study was to evaluate the construct and criterion validity of a newly developed Simulated Driving Assessment (SDA) for novice teen drivers. Methods The SDA's 35-minute simulated drive incorporates 22 variations of the most common teen driver crash configurations. Driving performance was compared for 21 inexperienced teens (age 16–17 years, provisional license ≤90 days) and 17 experienced adults (age 25–50 years, license ≥5 years, drove ≥100 miles per week, no collisions or moving violations ≤3 years). SDA driving performance (Error Score) was based on driving safety measures derived from simulator and eye-tracking data. Negative driving outcomes included simulated collisions or run-off-the-road incidents. A professional driving evaluator/instructor reviewed videos of SDA performance (DEI Score). Results The SDA demonstrated construct validity: 1.) Teens had a higher Error Score than adults (30 vs. 13, p=0.02); 2.) For each additional error committed, the relative risk of a participant's propensity for a simulated negative driving outcome increased by 8% (95% CI: 1.05–1.10, p<0.01). The SDA demonstrated criterion validity: Error Score was correlated with DEI Score (r=−0.66, p<0.001). Conclusions This study supports the concept of validated simulated driving tests like the SDA to assess novice driver skill in complex and hazardous driving scenarios. The SDA, as a standard protocol to evaluate teen driver performance, has the potential to facilitate screening and assessment of teen driving readiness and could be used to guide targeted skill training. PMID:25740939

  6. Duplex Doppler ultrasound study of the temporomandibular joint.

    PubMed

    Stagnitti, A; Marini, A; Impara, L; Drudi, F M; Lo Mele, L; Lillo Odoardi, G

    2012-06-01

    Sommario INTRODUZIONE: La fisiologia articolare dell’articolazione temporo-mandibolare (ATM) può essere esaminata sia dal punto di vista clinico che strumentale. La diagnostica per immagini ha da tempo contribuito con la risonanza magnetica (RM) e anche con la radiografia (Rx) e la tomografia computerizzata (TC) all’analisi della morfologia dei capi articolari e della cinetica condilare. L’esame duplex-ecodoppler è una metodica di largo impiego nello studio delle strutture in movimento in particolar modo a livello delle strutture del sistema vascolare. MATERIALI E METODI: È stata utilizzata un’apparecchiatura Toshiba APLIO SSA-770A, con l’uso di tecnica duplex-ecodoppler multi display, che consente la visualizzazione contemporanea dell’immagine ecografica e dei segnali Doppler utilizzando una sonda lineare del tipo phased array con cristalli trasduttori funzionanti ad una frequenza fondamentale di 6 MHz per gli spettri Doppler pulsati e 7.5 MHz per l’imaging ecografico. Sono stati esaminati nel Dipartimento di Scienze Radiologiche, Oncologiche e Anatomo-patologiche dell’Università “Sapienza” di Roma, 30 pazienti del reparto di Ortognatodonzia dell’Istituto di Odontoiatria della stessa Università. RISULTATI: Nei pazienti normali si è ottenuta un’alternanza regolare degli spettri Doppler, mentre nei soggetti con disfunzioni del complesso condilo-meniscale, si è persa la regolarità della sommatoria degli spettri di Fourier, con altezze incostanti in relazione a spostamenti irregolari del complesso condilo-meniscale. CONCLUSIONI: L’esame ecodoppler si è dimostrato, in tutti i pazienti, capace di discriminare quelli normali dai patologici e tra questi ultimi ha permesso di identificare gli aspetti più significativi delle patologie disfunzionali.

  7. [The nursing image in Italy: an analysis of the historic archive of national newspaper].

    PubMed

    Dignani, Lucia; Montanari, Paola; Dante, Angelo; Guarinoni, Milena Giovanna; Petrucci, Cristina; Lancia, Loreto

    2014-01-01

    Scopo. Descrivere l'immagine dell'infermiere delineata da uno dei principali quotidiani nazionali. Metodo. Studio retrospettivo condotto attraverso l'analisi degli articoli pubblicati nel periodo compreso tra il 1906 e il 2005 sul quotidiano nazionale “La Stampa”. Risultati.Dall'analisi dei 2017 articoli sono emerse 11 categorie tematiche. Gli articoli a maggior occorrenza sono stati quelli relativi alla tematica “cronaca”, che hanno registrato un importante incremento a partire dalla seconda metà degli anni '80, seguiti da “condizioni di lavoro”, che hanno mostrato massima diffusione a partire dagli anni '90. Gli articoli a minore occorrenza, invece, sono stati quelli riguardanti “estetica” e “concorsi”. Oltre la metà degli articoli inerenti la “carenza infermieristica” riferivano di disservizi da essa provocati. La quasi totalità degli articoli relativi a casi di “malasanità” evidenziava l'inadeguata assistenza erogata dagli infermieri con un trend di pubblicazione omogeneo a partire dagli anni '50. Gli articoli categorizzati nella tematica “carenza infermieristica”, “innovazione”, e “formazione”, hanno avuto la loro massima diffusione a partire dagli anni '90. Conclusioni. L'analisi condotta attraverso gli articoli apparsi sul quotidiano “La Stampa” ha consentito di leggere la storia della professione infermieristica come travagliata, fatta di conquiste professionali ottenute con lotte, rivendicazioni e innumerevoli cambiamenti, sia di tipo organizzativo che in ambito formativo, anche se gli articoli esaminati non sempre hanno contribuito a far apprezzare la professione per i suoi reali contenuti e contributi forniti al miglioramento della salute nella popolazione.

  8. [Cyberstalking among Italian nurses: a large multicentric study].

    PubMed

    Comparcini, Dania; Simonetti, Valentina; Lupo, Roberto; Galli, Francesco; Bocij, Paul; Cicolini, Giancarlo

    2016-01-01

    Scopo. Determinare la prevalenza di cyberstalking tra gli infermieri italiani e valutare il livello di ansia e depressione nelle vittime. Metodo. Da aprile a settembre 2014 è stato condotto uno studio multicentrico trasversale in un campione di infermieri italiani (n=997) utilizzando il questionario “Cyberstalking” per analizzare il fenomeno del cyberstalking. Ai partecipanti, che si sono autodefinite vittime di cyberstalking, è stato chiesto anche di compilare gli strumenti “Beck Depression Inventory” e “State-Trait Anxiety Inventory” per valutare, rispettivamente, i livelli di depressione ed ansia. Risultati. La prevalenza di cyberstalking tra gli infermieri italiani è risultata pari al 23.3%. Il 42.7% ha dovuto cambiare il proprio stile di vita e lavorativo. Il cyberstalker era prevalentemente di sesso maschile (52%) e, nel 49% dei casi, era un paziente. Le vittime hanno riferito moderati livelli di ansia (media=28.4, SD=23.2) e depressione (media=92.7, SD=18.3); i risultati hanno mostrato un aumento dei livelli di depressione negli infermieri esperti nell’utilizzo del computer, gestori di siti web o blog, e una correlazione negativa tra il livello di ansia e gli infermieri esperti (r = -0.264). Conclusioni. Il cyberstalking è un fenomeno che si riscontra frequentemente tra gli infermieri. Il rapporto infermiere - paziente gioca un ruolo centrale nello sviluppo del fenomeno e le vittime hanno riferito disordini correlati allo stress che influenzano la vita lavorativa. Questi risultati preliminari potrebbero sensibilizzare, i dirigenti ospedalieri, la politica e i centri antiviolenza al fine di sviluppare strategie risolutive a sostegno delle vittime.

  9. [The health care through the critical eyes of the users: a survey].

    PubMed

    Sacco, Carmelo; Castiglioni, Carlotta; Cocco, Gabriele; Vario, Massimiliano

    2016-01-01

    Introduzione: L’ospedalizzazione si configura come una condizione nella quale l’individuo cessa le sue normali attività quotidiane per essere preso in carico da una struttura ospedaliera, allo scopo di risolvere un problema di salute. Il personale sanitario ha la responsabilità di rendere l’evento “ricovero” il meno traumatico possibile, considerando l’accoglienza un momento cruciale, un “biglietto da visita” per la struttura, che condizionerà in buona parte l’esito di gradimento della degenza. Obiettivo: Esplorare l’esperienza di ricovero degli utenti intervistati, per delineare i temi princi- pali che influenzano la qualità assistenziale fornita nel contesto di due ospedali romani e, in rela- zione alle aree tematiche riscontrate, rilevare le criticità prevalenti. Metodo: raccolta dati attraverso somministrazione di questionari semi-strutturati, successivo approccio fenomenologico focalizzato all’analisi dei vissuti esperienziali delle persone reclutate per estrarne i temi di significato con tecnica induttiva di Van Kaam. Risultati: Dalle interviste effettuate aventi per oggetto il vissuto dell’utente rispetto all’esperienza dell’ospedalizzazione, sono stati delineati 4 elementi essenziali che condizionano la qualità dell’as- sistenza fornita e, in questi, rilevate le criticità più evidenti; si è evidenziata pertanto un’asimme- tria relazionale e comunicativa tra operatore sanitario e utente ed inoltre una scarsa consapevo- lezza del personale sanitario riguardo l’importanza del “primacy effect”, quale elemento prelimi- nare per rafforzare le successive percezioni positive delle cure ospedaliere. Conclusioni: Alla luce dei risultati emersi, lo studio può fornire interessanti spunti ed indica- zioni a tutti coloro che, a diverso titolo, operano nell’ambito delle professioni sanitarie.

  10. [Shared decision making: a scoping review].

    PubMed

    Guarinoni, Milena Giovanna; Dignani, Lucia; Motta, Paolo Carlo

    2016-01-01

    Scopo. L’obiettivo primario dello studio è implementare e utilizzare uno strumento validato per misurare il fenomeno delle dimissioni difficili, che possa supportare il personale infer- mieristico nella programmazione della dimissione del paziente ricoverato nei reparti di Geria- tria e Medicina. Gli obiettivi secondari sono: - Sperimentare l’utilizzo dell’indice di BRASS - Studiare le caratteristiche della popolazione a rischio di dimissione difficile Metodo. studio osservazionale prospettico per misurare il fenomeno delle dimissioni difficili attraverso l’implementazione dell’indice di BRASS nei reparti di Geriatria e Medicina dell’Ospedale di Rovigo Ulss 18, al fine di studiare le caratteristiche della popolazione a rischio di dimissione difficile. Risultati. In un campione di 165 pazienti il 42,4% (70) era rispettivamente a rischio alto e medio di dimissione difficile, mentre il 15,2% (25) era a basso rischio. La media dei punteggi BRASS era di 18,76. Il 37,6% dei pazienti ad alto rischio erano ricoverati in Geriatria, mentre in Medicina i pazienti si concentrano maggiormente nella classe medio rischio. Conclusioni. Lo studio ha permesso di misurare il fenomeno delle dimissioni difficili classi- ficando i pazienti nei gruppi di rischio. L’analisi delle dimissioni protette ha fatto emergere la congruenza tra punteggio BRASS e caratteristiche del campione. Lo strumento non richiede tempi di compilazione lunghi, è di supporto al processo decisionale dell’infermiere perché rileva la necessità di creare un percorso strutturato sulla dimissione del paziente, in modo sistematico e programmato, evitando la dispersione di informazioni importanti al fin di garantire la continuità assistenziale.

  11. Antibiotic treatments in zootechnology and effects induced on the food chain of domestic species and, comparatively, the human specie.

    PubMed

    Palmieri, Beniamino; Di Cerbo, Alessandro; Laurino, Carmen

    2014-06-01

    Introducción: los antibióticos se emplean ampliamente en la alimentación zootécnica para proteger a las especies humana y animal de las zoonosis por agentes infecciosos patogénicos. Objetivo: dado el creciente número de enfermedades relacionadas con la dieta (p. ej., intolerancias alimentarias), investigamos los efectos tóxicos inducidos por los residuos antibióticos, oxitetraciclinas, presentes en los alimentos industriales tanto sobre la salud humana como animal. Se destacan los productos zootécnicos obtenidos de la transformación industrial de los huesos animales y sus efectos tóxicos relacionados. Métodos: análisis comparativo de las publicaciones realizadas desde 1910 hasta 2014. Resultados: el análisis comparativo reveló la presencia de residuos de oxitetraciclina y otros antibióticos en alimentos pensados para el consumo humano y animal, lo que produjo efectos tóxicos multisistémicos. Discusión: el metabolismo y las posibles medidas para evitar la exposición a la oxitetraciclina también se han examinado, sin embargo, se precisa de un conocimiento más detallado de los efectos bioquímicos de tal clase de antibióticos.

  12. The advances and new technologies for the study of mitochondrial diseases.

    PubMed

    Bianco, Bianca; Montagna, Erik

    2016-01-01

    ABSTRACTGenetic mitochondrial disorders are responsible for the most common inborn errors of metabolism, caused by mutations in either nuclear genes or in mitochondrial DNA. This article presents the prokaryotic origin of the organelle and the relation between nuclear and mitochondrial genomes, as well as current evolutionary models for such mechanisms. It also addresses the structure of mitochondrial genes, their expression pattern, clinical features of gene defects, risk of transmission and current techniques to avoid these events in assisted human reproduction. Finally, it discusses the ethical implications of these possibilities.RESUMOAs doenças genéticas mitocondriais são responsáveis pelos erros inatos do metabolismo mais comuns, causados por mutações tanto em genes nucleares como no DNA mitocondrial. Este artigo apresenta a origem procariótica dessa organela, e a relação entre os genomas nuclear e mitocondrial, bem como modelos evolutivos correntes para esses mecanismos. Também trata da estrutura dos genes mitocondriais, seu padrão de expressão, características clínicas de defeitos genéticos, riscos de transmissão e técnicas atualmente utilizadas para evitar esses eventos em reprodução humana assistida. Finalmente, discute as implicações éticas dessas possibilidades.

  13. [Autism spectrum disorder and epilepsy: the role of ketogenic diet].

    PubMed

    Garcia-Penas, J J

    2016-01-01

    Introduccion. Un 5-40% de los pacientes autistas desarrolla epilepsia. Aunque generalmente se controlan bien con medicacion, hasta un 20-30% de estas epilepsias son refractarias al tratamiento farmacologico. En esta poblacion, la dieta cetogenica (DC) puede ser una terapia alternativa altamente eficaz y debe considerarse seriamente. Objetivo. Revisar el papel de la DC en el tratamiento de la epilepsia infantil refractaria y en los pacientes que asocian autismo y epilepsia. Desarrollo. La DC es un tratamiento eficaz y bien tolerado para las epilepsias infantiles refractarias, incluyendo los pacientes que asocian autismo y epilepsia. Es fundamental caracterizar de forma precisa el sindrome epileptico para conocer cuales son los mejores candidatos para tratar con DC. Por otra parte, el efecto positivo de la DC sobre las alteraciones del metabolismo oxidativo mitocondrial y la evidencia experimental obtenida con DC en animales autistas sugieren que pueda ser una alternativa eficaz en los pacientes con autismo. Conclusiones. Basandose en la utilidad demostrada de la DC en el tratamiento de pacientes con epilepsia y autismo, esta terapia se ha usado en los ultimos años como una terapia alternativa para los pacientes autistas, aunque se desconoce cual es su eficacia real. Es necesario realizar un estudio aleatorizado y controlado para definir el perfil de eficacia y seguridad en esta poblacion.

  14. Vitamin d deficiency is associated with insulin resistance independent of intracellular calcium, dietary calcium and serum levels of parathormone, calcitriol and calcium in premenopausal women.

    PubMed

    Ferreira, Thaís da Silva; Rocha, Tatiana Martins; Klein, Márcia Regina Simas Torres; Sanjuliani, Antonio Felipe

    2015-04-01

    Introducción: Hay evidencias de que la deficiencia de vitamina D se asocia con mayor riesgo de enfermedad cardiovascular. Sin embargo, no se sabe si esta asociación es independiente de calcio en la dieta, el calcio intracelular y los niveles séricos de hormona paratiroidea, calcitriol y calcio. Objetivos: investigar la relación independiente de la deficiencia de vitamina D con resistencia a la insulina, el perfil lipídico, el estado inflamatorio, la presión arterial y la función endotelial. Métodos: Estudio transversal realizado con 73 mujeres pre menopáusicas sanas brasileñas con edad 18-50 años. Todos los participantes fueron evaluados para: niveles séricos de 25 hidroxivitamina D, parámetros antropométricos, la composición corporal, metabolismo del calcio, resistencia a la insulina, el perfil de lipoproteínas, estado inflamatorio, la presión arterial y la función endotelial. La función endotelial fue evaluada por el índice de hiperemia reactiva mediante el uso de Endo-PAT 2000®. Las mujeres fueron estratificados en dos grupos: con deficiencia de vitamina D (25 hidroxivitamina D.

  15. [Neurological appraisal of children and adolescents with psychotic symptoms].

    PubMed

    Tomás-Vila, Miguel

    2015-05-01

    Introduccion. Las manifestaciones psicoticas en la infancia no son infrecuentes; sin embargo, la bibliografia existente acerca de la valoracion neurologica de niños y adolescentes con cuadros psicoticos es muy escasa. Objetivo. Realizar una revision bibliografica no sistematica que permita responder a estas tres cuestiones: cuando debe llevarse a cabo una valoracion neurologica en un niño con rasgos psicoticos?, cuales son las condiciones medicas que pueden incluir un cuadro psicotico en su evolucion? y cual debe ser el procedimiento diagnostico? Desarrollo. Se revisan las enfermedades que pueden presentar sintomatologia psicotica al inicio o durante la evolucion, y se agrupan por patologias: errores congenitos del metabolismo, enfermedades geneticas, enfermedades autoinmunes e infecciosas, malformaciones del sistema nervioso central, epilepsia, patologia vascular, procesos reumatologicos, tumores cerebrales, y farmacos y sustancias psicoactivas. Se propone una pauta diagnostica en la que se valora la informacion obtenida a partir de la anamnesis y la exploracion y la aportacion de cada prueba diagnostica. Conclusiones. El numero de procesos que pueden manifestar sintomatologia psicotica a lo largo de su evolucion es muy elevado, y hay que considerar las claves que ofrecen la anamnesis y la exploracion. Esta revision puede ayudar a neuropediatras y otros especialistas a realizar una valoracion mas sistematizada de niños y adolescentes con cuadros psicoticos.

  16. The presence and accuracy of food and nutrition terms in the Spanish and English editions of Wikipedia: in comparison with the Mini Larousse encyclopaedia.

    PubMed

    Cabrera-Hernández, Laura María; Wanden-Berghe, Carmina; Curbelo Castro, Celeste; Sanz-Valero, Javier

    2014-10-02

    Objetivos: Determinar la presencia y adecuación de la terminología sobre las ciencias de la alimentación/nutrición en las ediciones española e inglesa de la Wikipedia, comparándola con una enciclopedia de ámbito general (Mini Larousse). Métodos: Los términos a estudio se obtuvieron del Diccionario LID sobre metabolismo y nutrición. Se comprobó la existencia y adecuación de los términos seleccionados a partir del cálculo muestral aleatorio sin reposición (n = 386), accediendo a las ediciones española e inglesa de la Wikipedia. Resultados: De la muestra a estudio (n=386) se determinó la existencia de 261 términos en la edición española y 306 en la inglesa. Existiendo diferencias entre las dos ediciones (p.

  17. [Effect of alcohol on electrical organisation in the brain during a visuospatial working memory task and its relationship with the menstrual cycle].

    PubMed

    Sanz-Martin, Araceli; Hernández-González, Marisela; Guevara, Miguel Ángel; Santana, Gloria; Gumá-Díaz, Emilio

    2014-02-01

    Introduccion. El metabolismo del alcohol y el desempeño de muchas funciones cognitivas pueden variar a lo largo del ciclo menstrual. Tanto la ingestion de alcohol como las variaciones hormonales durante el ciclo menstrual se asocian con cambios caracteristicos en la actividad electroencefalografica. Objetivo. Determinar si la actividad electroencefalografica durante una tarea de memoria de trabajo es afectada por el consumo agudo de alcohol, y si dicha actividad varia en funcion del ciclo menstrual. Sujetos y metodos. Muestra de 24 mujeres que ingirieron alcohol o placebo durante las fases folicular y lutea temprana. Se registro el electroencefalograma durante la ejecucion de una tarea de memoria de trabajo visuoespacial. Resultados. Aunque el alcohol no deterioro el rendimiento de la tarea de memoria de trabajo, si produjo en el electroencefalograma una disminucion de la potencia relativa de theta y una menor correlacion frontoparietal derecha en las bandas theta y alfa2. Unicamente las mujeres alcoholizadas en la fase folicular presentaron una mayor potencia relativa de alfa1, que podria indicar menor nivel de alertamiento y atencion. Conclusiones. Estos resultados contribuyen a una mejor comprension de los mecanismos cerebrales que subyacen a los cambios cognitivos con el alcohol y su relacion con el ciclo menstrual.

  18. [Phenotypic variations in Aicardi-Goutieres syndrome caused by RNASEH2B gene mutations: report of two new cases].

    PubMed

    Ortiz-Madinaveitia, Saturnino; Conejo-Moreno, David; López-Pisón, Javier; Peña-Segura, José Luis; Serrano-Madrid, M Luisa; Durán-Palacios, Ingrid C; Peláez-Cabo, Pilar

    2016-02-16

    Introduccion. El sindrome de Aicardi-Goutieres es un trastorno inmunitario raro debido a mutaciones en siete genes que codifican proteinas llamadas TREX1, el complejo ribonucleasa H2, SAMHD1, ADAR e IFIH1 (MAD5), las cuales estan implicadas en el metabolismo de los acidos nucleicos. A continuacion se presentan dos nuevos casos por mutacion en el gen RNASEH2B, uno de los cuales presenta una mutacion no descrita hasta la fecha. Casos clinicos. Caso 1: varon que consulto porque desde los 5 meses, coincidiendo con cuadros febriles de repeticion, presentaba perdida de los items madurativos adquiridos hasta la fecha. Caso 2: niño de 4 meses que desde los 2 meses mostraba gran irritabilidad con dificultades en la alimentacion, asociado a un grave retraso psicomotor. En ambos casos se constato un aumento de las pterinas en el liquido cefalorraquideo, principalmente de la neopterina, con calcificaciones en los ganglios basales. El diagnostico se confirmo mediante secuenciacion del gen RNASEH2B; el caso 2 presentaba una mutacion no descrita en la literatura medica. Conclusiones. Los casos corresponden a la descripcion clasica realizada por Aicardi-Goutieres. Debe tenerse en cuenta este sindrome ante un paciente con un cuadro de encefalopatia subaguda de comienzo en el primer año de vida, distonia/espasticidad en grado variable e importante afectacion/regresion del desarrollo psicomotor, especialmente si asocia aumento de las pterinas (neopterina) en el liquido cefalorraquideo y calcificaciones en los ganglios basales.

  19. Introduzione Nuove tecnologie in urologia.

    PubMed

    Bianchi, Giampaolo

    2011-03-30

    Negli ultimi anni sono state introdotte in urologia nuove tecniche chirurgiche alcune già applicabili nella pratica clinica, altre ancora in corso di sperimentazione. Quella che ha trovato attualmente applicazione è la LESS (Laparo Endoscopic Single-site Surgery); essa riguarda tutte le metodiche che utilizzano una sola porta (multiaccesso) per eseguire interventi laparoscopici. I vantaggi apparenti di questa metodica rispetto alla laparoscopia tradizionale sono soltanto un dimostrato miglior risultato estetico. Mancano studi prospettici randomizzati. NOTES (Natural Orifices Transluminal Endoscopic Surgery) È una metodica ancor più nuova che sfrutta gli orifizi naturali (bocca, retto, vagina, vescica per accedere alla cavità addominale. Rispetto alla LESS questa tecnica utilizza prevalentemente i gastroscopi e lo strumentario dei gastoenterologi per eseguire interventi demolitivi. In urologia l'impiego di questa metodica è puramente sperimentale, comunque piccoli passi sono stati fatti nel migliorare lo strumentario. I chirurghi stanno consolidando questa metodica sull'uomo riguardo alla colecistectomia, ma i risultati sono scarsi, discordanti sulla via d'accesso e limitati a case reports. Oggi i risultati più incoraggianti li ha descritti Estevao Lima, un ingegnoso portoghese che utilizzando una tecnica NOTES di terza generazione (accesso combinato trans-vescicale e trans-gastrico) è riuscito ad eseguire una serie di nefrectomie sul maiale. Tanto si sa e si è speculato riguardo al robot da Vinci®, che oggi la prostatectomia senza di lui non è più competitiva. Moltissimi sono i centri che lo hanno, molti quelli che lo usano, tanti quelli che hanno risultati migliori rispetto alla tecnica laparoscopica classica. Ancora ad oggi però non esistono studi prospettici randomizzati che dimostrino la sua superiorità; inoltre una spina nel fianco sono i costi. Un ulteriore sviluppo futuro di da Vinci® forse potrebbe vedersi nell'assistere le nuove tecniche

  20. Il ruolo svolto dall’attività lavorativa sull’ipertensione arteriosa

    PubMed Central

    Barbini, N.; Gorini, G.; Ferrucci, L.; Biggeri, A.

    2009-01-01

    RIASSUNTO Introduzione I parametri di pressione arteriosa, sistolica (PAS) o diastolica (PAD) hanno costituito I’oggetto di numerosi studi, alcuni dei quali stabiliscono un’associazione tra I’aumnto di tali parametri e la mortalità, in particolare alle età medie. I fattori di rischio di ipertensione più frequentemente studiati sono il consumo di alcol, il fumo e I’origine etnica in riferimento sia alle differenze genetiche che nella condotta alimentare, mentre i fattori di origine professionale sono stati presi in considerazione più raramente e in maniera poco approfondita, inoltre sono state riferite notevoli differenze nelle pressioni arteriose medie di individui che svolgono professioni diverse. Sembra infatti che i “colletti blu” siano più a rischio dei “colletti bianchi”. Obiettivi Il nostro scopo è valutare se determinati rischi o vincoli connessi con l’attività professionale o determinati stili di vita rappresentano un fattore di rischio per l’ipertensione arteriosa in considerazioni dell’aumentare dell’età. Elementi specifici che rendano conto di questa relazione non sono stati ancora completamente chiariti e soprattutto i dati sulla popolazione italiana sono molto limitati. Metodi La metodologia di ricerca utilizzata è stata quella dell’indagine francese ESTEV (Derriennic, Touranchet, Volkoff) - VISAT (Marquie, Janson), studio epidemiologico longitudinale su oltre 23000 lavoratori attivata in Francia nel 1990 al fine di indagare gli effetti a lungo termine delle condizioni di lavoro, riferite all’intera vita professionale, sia sull’invecchiamento sia sulla salute dei lavoratori. Analoga indagine è stata avviata in Italia, nel 2000, in 6 Regioni, prendendo in esame i lavoratori dipendenti di diversi settori produttivi appartenenti a 5 coorti di età: da 32 a 52 anni con intervallo di 5 anni. Le rilevazioni sono state effettuate dai medici del lavoro di azienda attraverso 3 questionari: 1. sulle condizioni

  1. A 16-year experience of carotid artery stenting for carotid artery stenosis.

    PubMed

    Nano, Giovanni; Stegher, Silvia; Occhiuto, Maria Teresa; Muzzarelli, Lorenzo; Malacrida, Giovanni; Mazzaccaro, Daniela P

    2016-01-01

    Da più di 50 anni l’endoarteriectomia carotidea (CEA) è stata considerata il trattamento standard per le stenosi carotidee gravi asintomatiche e sintomatiche. Lo stenting carotideo (CAS) è progressivamente emerso negli ultimi 15 anni come alternativa alla chirurgia, specialmente nei pazienti ad alto rischio. Da allora, molti studi clinici randomizzati sono stati pubblicati per valutare la superiorità di un metodo rispetto all’altro, tuttavia i risultati dei trials hanno generato più dubbi che certezze nell’interpretazione dei loro risultati, gravati come sono da diverse limitazioni: la principale riguarda la ridotta competenza endovascolare richiesta per gli operatori che hanno eseguito lo stenting carotideo e partecipato ai trials. Inoltre questi trials sono stati eseguiti circa 10 anni fa, con materiali e farmaci differenti rispetto a quelli usati attualmente. Attualmente i registri su larga scala e le casistiche che riportano risultati a lungo termine sono maggiormente rappresentativi di una esperienza reale, che riflette ciò che accade di routine nella pratica clinica. Nella nostra Unità Operativa di Chirurgia Vascolare, il CAS è stato offerto dal 1999 come alternativa alla CEA per il trattamento delle stenosi carotidee sintomatiche e asintomatiche nei pazienti a rischio moderato-alto. Scopo del nostro lavoro è di riportare la nostra esperienza retrospettiva, con alcuni consigli e suggerimenti che derivano da ciò che abbiamo imparato in più di 16 anni. Abbiamo pertanto raccolto e analizzato retrospettivamente i dati di tutti i pazienti consecutivi che sono venuti per una stenosi carotidea significativa dal 1 ° gennaio 1999 al 31 agosto 2015. I risultati basilari sono stati la mortalità e la morbilità cerebrovascolare maggiore (MCE) sia a 30 giorni che a lungo termine. Lo studio è stato condotto su 1017 pazienti (677 maschi, 66.6%, età media 74 anni, IQR 69-79 anni) trattati sia per stenosi carotidea sintomatica (n=392, 38.5%) che

  2. Polypoid anal melanoma. A case report and review of the literature.

    PubMed

    Tutino, Roberta; Clerico, Giuseppe; Luc, Alberto Realis; Gallo, Gaetano; Trompetto, Mario

    2016-11-12

    Il melanoma ano-rettale è una patologia rara, rappresentando l’1% dei tumori anali e lo 0.4-1.6% dei melanomi. I suoi sintomi sono simili a quelli delle più comuni malattie benigne della regione anorettale, portando spesso a diagnosi in stadi avanzati, in particolare se la sede del tumore è a livello del canale anale. In ogni caso la prognosi del melanoma anorettale rimane severa con una sopravvivenza a 5 anni che non supera il 22% negli stadi più precoci. La letteratura presenta saltuarie serie monocentriche ed alcuni case report e a tutt’oggi non vi sono linee-guida per il suo management. La classificazione più usata divide la malattia in tre stadi a seconda del coinvolgimento o meno dei linfonodi regionali e della presenza di metastasi a distanza. Un’analisi di popolazione ha mostrato una sopravvivenza a 5 anni del 17%, 18% e 5% rispettivamente per i tre stadi di malattia dopo chirurgia e dello 0%, 0% e 4% in assenza di trattamento. La risonanza magnetica e l’ecoendoscopia sono utili per la valutazione di operabilità locale mentre la TAC e la PET sono indicati per la valutazione di eventuali metastasi a distanza. I fattori di rischio per recidiva sono l’invasione perineurale, la necrosi tumorale, dimensioni superiori a 2 cm ed un’istologia con cellule fusate o miste. I protocolli poli-chemioterapici utilizzati sinora per il melanoma anorettale hanno purtroppo portato a risultati meno soddisfacenti di quelli ottenuti nel trattamento del melanoma cutaneo. La mutazione del c-KIT ed i trattamenti con i suoi inibitori sembrano dimostrare risultati promettenti mentre la radioterapia non sembra attualmente rivestire alcun ruolo terapeutico rilevante. Abbiamo riportato il caso di una donna di 55 anni visitata presso un ambulatorio di coloproctologia per rettorragia saltuaria ed un dolore anale che ha reso impossibile la valutazione clinica locale. La valutazione in anestesia ha rivelato la presenza di una massa polipoide di colorito brunastro del

  3. Stimulant Reduction Intervention using Dosed Exercise (STRIDE) - CTN 0037: Study protocol for a randomized controlled trial

    PubMed Central

    2011-01-01

    Background There is a need for novel approaches to the treatment of stimulant abuse and dependence. Clinical data examining the use of exercise as a treatment for the abuse of nicotine, alcohol, and other substances suggest that exercise may be a beneficial treatment for stimulant abuse, with direct effects on decreased use and craving. In addition, exercise has the potential to improve other health domains that may be adversely affected by stimulant use or its treatment, such as sleep disturbance, cognitive function, mood, weight gain, quality of life, and anhedonia, since it has been shown to improve many of these domains in a number of other clinical disorders. Furthermore, neurobiological evidence provides plausible mechanisms by which exercise could positively affect treatment outcomes. The current manuscript presents the rationale, design considerations, and study design of the National Institute on Drug Abuse (NIDA) Clinical Trials Network (CTN) CTN-0037 Stimulant Reduction Intervention using Dosed Exercise (STRIDE) study. Methods/Design STRIDE is a multisite randomized clinical trial that compares exercise to health education as potential treatments for stimulant abuse or dependence. This study will evaluate individuals diagnosed with stimulant abuse or dependence who are receiving treatment in a residential setting. Three hundred and thirty eligible and interested participants who provide informed consent will be randomized to one of two treatment arms: Vigorous Intensity High Dose Exercise Augmentation (DEI) or Health Education Intervention Augmentation (HEI). Both groups will receive TAU (i.e., usual care). The treatment arms are structured such that the quantity of visits is similar to allow for equivalent contact between groups. In both arms, participants will begin with supervised sessions 3 times per week during the 12-week acute phase of the study. Supervised sessions will be conducted as one-on-one (i.e., individual) sessions, although other

  4. Multimodality imaging of bilateral pheochromocytoma. A case report.

    PubMed

    Paladino, Nunzia Cinzia; Lowery, Aoife; Guérin, Carole; Taïeb, David; Sebag, Frédéric

    2015-06-22

    I feocromocitomi bilaterali sono rari; nella maggior parte dei casi presentano origine ereditaria e sono legati a mutazioni germinali relative ai geni RET, VHL o SDHx, tuttavia in altri casi non viene ritrovata alcuna eziologia. A tal proposito riportiamo il caso clinico di una donna di 76 anni, giunta alla nostra osservazione per malessere generale sopravvenuto in concomitanza di crisi ipertensive responsabili di ospedalizzazione. Il profilo ormonale realizzato in tale occasione, era suggestivo di feocromocitoma (metanefrine plasmatiche ed urinarie 10 volte superiori al range di normalità). Gli esami radiologici (TC e RMN) rivelavano due lesioni surrenaliche bilaterali di diametro rispettivamente a destra di 47 mm ed a sinistra di 26 mm. Mentre la TC definiva le dimensioni di queste lesioni, il loro carattere eterogeneo e la loro ipervascolarizzazione oltre ai rapporti con gli organi adiacenti, la RMN si esprimeva già in favore di feocromocitoma bilaterale. La scintigrafia alla MIBG mostrava una iperfissazione a carico della lesione surrenalica destra mentre sulla surrenale controlaterale evidenziava una fissazione limitata, relativa alla midollare normale. Tenuto conto del forte sospetto di feocromocitoma bilaterale, veniva eseguita una TEP alla 18F-FDOPA che mostrava un intenso ipermetabolismo a carico della massa surrenalica destra, mentre controlateralmente una fissazione simile a quella del fegato e pertanto non sospetta, nonostante molti studi sostengano una sensibilità uguale o addirittura superiore della TEP alla 18-FDOPA rispetto alla scintigrafia MIBG nei pazienti con feocromocitoma o paraganglioma. In un primo tempo veniva eseguita una surrenalectomia destra per via laparoscopica. In fase post-operatoria, in seguito alla constatazione del persistente incremento delle metanefrine plasmatiche ed urinarie, veniva realizzata una TEP alla 18 FDG che confermava la presenza di un’area di ipermetabolismo intenso a carico della lesione surrenalica sinistra

  5. An approach to complicated diverticular disease. A retrospective study in an Acute Care Surgery service recently established.

    PubMed

    Occhionorelli, Savino; Zese, Monica; Tartarini, Daniela; Lacavalla, Domenica; Maccatrozzo, Stefano; Groppo, Giacomo; Sibilla, Maria Grazia; Stano, Rocco; Cappellari, Lorenzo; Vasquez, Giorgio

    2016-01-01

    Obiettivo: La patologia diverticolare acuta è attualmente molto frequente nei paesi occidentalizzati. L’aumento costante del numero dei pazienti ricoverati nelle Unità operative di Chirurgia per il trattamento d’Urgenza sta portando alla necessità di individuare nuove Classificazioni e Scores per il corretto e razionale trattamento medico e chirurgico, anche in relazione all’assenza di linee guida ufficiali. Metodi: Si tratta di uno studio retrospettivo che prende in considerazione tutti i pazienti ricoverati presso il nostro Dipartimento, con diagnosi di diverticolite acuta perforata, nel periodo di tempo compreso tra giugno 2010 e marzo 2015. Risultati: Nel nostro studio 41 pazienti sono stati trattati conservativamente. I restanti 58 pazienti sono stati sottoposti ad intervento chirurgico: 25 con procedura di Hartmann, 29 con intervento di resezione e consensuale confezionamento di anastomosi senza ileostomia di protezione, 3 pazienti sono stati sottoposti a riparazione diretta della lesione diverticolare (rafia) e 2 a lavaggio peritoneale laparoscopico con posizionamento di drenaggio. Di questi ultimi due pazienti, uno è stato dimesso dopo 7 giorni in buone condizioni cliniche generali ed uno è stato poi sottoposto a resezione e confezionamento di anastomosi. Abbiamo correlato i pazienti suddividendoli nei vari gruppi Hinchey modificati e sovragruppi, associandoli ai diversi trattamenti, identificandone i fattori di rischio, l’ASA score e le complicanze. Discussione: L’utilizzo di nuove tecnologie, come la TC, si sta rivelando molto utile per la diagnosi delle diverticoliti perforate. Il loro trattamento è invece ancora piuttosto dibattuto: per i pazienti Hinchey I e II è, tendenzialmente conservativo, a meno di fattori concomitanti che ne pregiudichino l’andamento clinico. I pazienti Hinchey III e IV sono di competenza chirurgica. Il trattamento preferenziale è la procedura di Hartmann ma negli ultimi anni la resezione con consensuale

  6. Kentucky Pioneer Integrated Gasification Combined Cycle Demonstration Project Draft Environmental Impact Statement

    SciTech Connect

    N /A

    2001-11-16

    The Kentucky Pioneer IGCC Demonstration Project DEIS assesses the potential environmental impacts that would result from a proposed DOE action to provide cost-shared financial support for construction and operation of an electrical power station demonstrating use of a Clean Coal Technology in Clark County, Kentucky. Under the Proposed Action, DOE would provide financial assistance, through a Cooperative Agreement with Kentucky Pioneer Energy, LLC, for design, construction, and operation of a 540 megawatt demonstration power station comprised of two synthesis gas-fired combined cycle units in Clark County, Kentucky. The station would also be comprised of a British Gas Lurgi (BGL) gasifier to produce synthesis gas from a co-feed of coal and refuse-derived fuel pellets and a high temperature molten carbonate fuel cell. The facility would be powered by the synthesis gas feed. The proposed project would consist of the following major components: (1) refuse-derived fuel pellets and coal receipt and storage facilities; (2) a gasification plant; (3) sulfur removal and recovery facilities; (4) an air separation plant; (5) a high-temperature molten carbonate fuel cell; and (6) two combined cycle generation units. The IGCC facility would be built to provide needed power capacity to central and eastern Kentucky. At a minimum, 50 percent of the high sulfur coal used would be from the Kentucky region. Two No Action Alternatives are analyzed in the DEIS. Under the No Action Alternative 1, DOE would not provide cost-shared funding for construction and operation of the proposed facility and no new facility would be built. Under the No Action Alternative 2, DOE would not provide any funding and, instead of the proposed demonstration project, Kentucky Pioneer Energy, LLC, a subsidiary of Global Energy, Inc., would construct and operate, a 540 megawatt natural gas-fired power station. Evaluation of impacts on land use, socioeconomics, cultural resources, aesthetic and scenic resources

  7. A Transportation Risk Assessment Tool for Analyzing the Transport of Spent Nuclear Fuel and High-Level Radioactive Waste to the Proposed Yucca Mountain Repository

    SciTech Connect

    Ralph Best; T. Winnard; S. Ross; R. Best

    2001-08-17

    The Yucca Mountain Transportation Database was developed as a data management tool for assembling and integrating data from multiple sources to compile the potential transportation impacts presented in the Draft Environmental Impact Statement for a Geologic Repository for the Disposal of Spent Nuclear Fuel and High-Level Radioactive Waste at Yucca Mountain, Nye County, Nevada (DEIS). The database uses the results from existing models and codes such as RADTRAN, RISKIND, INTERLINE, and HIGHWAY to estimate transportation-related impacts of transporting spent nuclear fuel and high-level radioactive waste from commercial reactors and U. S. Department of Energy (DOE) facilities to Yucca Mountain. The source tables in the database are compendiums of information from many diverse sources including: radionuclide quantities for each waste type; route and route characteristics for rail, legal-weight truck, heavy haul. truck, and barge transport options; state-specific accident and fatality rates for routes selected for analysis; packaging and shipment data by waste type; unit risk factors; the complex behavior of the packaged waste forms in severe transport accidents; and the effects of exposure to radiation or the isotopic specific effects of radionclides should they be released in severe transportation accidents. The database works together with the codes RADTRAN (Neuhauser, et al, 1994) and RISKlND (Yuan, et al, 1995) to calculate incident-free dose and accident risk. For the incident-free transportation scenario, the database uses RADTRAN and RISKIND-generated data to calculate doses to offlink populations, onlink populations, people at stops, crews, inspectors, workers at intermodal transfer stations, guards at overnight stops, and escorts, as well as non-radioactive pollution health effects. For accident scenarios, the database uses RADTRAN-generated data to calculate dose risks based on ingestion, inhalation, resuspension, immersion (cloudshine), and groundshine as

  8. Environmental analysis of the sediments in the beaches of the Gulf of Palermo (Italy)

    NASA Astrophysics Data System (ADS)

    Liguori, Vincenzo; Manno, Giorgio

    2016-04-01

    The gulf of Palermo is long about 30 km and the coast is closed between two headlands, Monte Gallo Cape (western side) and Zafferano Cape (east side). The continental shelf is linked with the abyssal plan by an high slope and the depth is included between 50 m and 1500 m. The shape of the Palermo gulf is the answer of both the natural forces and human activity. Nevertheless the coastal morphologies reproduce the geological setting of this area. The coast is divided in two morphotypes, low and rocky coast and beaches. Respectively composed by compact limestone and calcareous incoherent sediment with common sandy granulometry. The beaches, compressively long 11,46 km, are different in lengths, amplitude and lithological types (30% sandy and 70 % sandy-pebbly). In order to study the coastal evolution it is important to define all the coastal dynamics. The coastal evolution is actually the result of complex and intertwined action of both natural and/or anthropic processes. Nowday in the gulf of Palermo these processes exist and in some case they already triggered erosive phenomena. The westernmost beaches is the famous Mondello beach, it is made of pale sand and with sloping very low. This section of coast as other similar beaches (Arenella, Romagnolo and Acqua dei Corsari) has gone through remarkable dynamic phenomena. More precisely between 1976 and 1992 the beach (known as Arenella beach), beyond the Palermo harbor, advanced its shoreline position. Going further west along the coast one can find a landfill, partially collapsed and eroded by the impact of sea storms, that contributes to the coastal advancement from West towards East. At Romagnolo coast zone the beach has advanced because of the debris coming from local landfills, instead the Acqua dei Corsari beach (pebbles and sand) has been going through various fluctuations with a general trend towards advancement due to the longitudinal sediment transport. The study analyze the nature of sediments that made the

  9. [Efficacy of educational intervention for patients wearing peripherall inserted central catheter. A pilot study].

    PubMed

    Fusco, Federica; Armando, Tiziana; Storto, Silvana; Mussa, Maria Valentina

    2016-01-01

    Introduzione: Il Peripherally Inserted Central Catheter (PICC) è un catetere venoso centrale adatto per pazienti in regime di Day Hospital. Il suo utilizzo è considerato vantaggioso ma comporta degli oneri di gestione a carico della persona. E' bene formare il paziente ad una corretta gestione domiciliare del presidio attraverso un'educazione strutturata. Obiettivo: In un gruppo di pazienti portatori di PICC, valutare l'efficacia di un intervento educativo mirato attraverso la comparazione di: colloquio informativo, opuscolo cartaceo, video informativo. Metodo: Studio clinico randomizzato e controllato monocentrico, schema comparativo semplice a tre bracci. Popolazione: tutti i pazienti sottoposti all'impianto di PICC nel periodo di osservazione tra Ottobre 2013 e Febbraio 2014 presso l'Unità Operativa Day Hospital Oncologico e Breast Unit, presidio Molinette di Torino. L'intervento educativo standard è erogato attraverso un colloquio con l'infermiere che esegue l'impianto. Il team di impiantatori è costituito da due infermieri con comprovata esperienza in ambito oncologico ed in possesso di Master di I Livello "Gestione degli accessi venosi". I pazienti eleggibili, dopo randomizzazione, sono stati divisi in tre gruppi: gruppo A colloquio informativo; gruppo B opuscolo; gruppo C video. I pazienti dei gruppi B e C hanno ricevuto informazioni standard inte- grate con informazioni audiovisive oppure cartacee, in base al braccio al quale erano stati destinati; il grado di conoscenza raggiunto è stato indagato attraverso la somministrazione di questionari costruiti ad hoc, non vali- dati in quanto non presenti in letteratura. Risultati: Adesione allo studio di 40 pazienti, campione di convenienza costituito da persone di età compresa tra 18 e 75 anni, consenzienti e risiedenti al proprio domicilio. L'analisi delle conoscenze apprese in seguito all'intervento educativo mostra una differenza statisticamente significativa in diversi ambiti necessari per la

  10. [Population health surveillance of the general population living near Turin (Northern Italy) incinerator (SPoTT): methodology of the study].

    PubMed

    Bena, Antonella; Chiusolo, Monica; Orengia, Manuela; Cadum, Ennio; Farina, Elena; Musmeci, Loredana; Procopio, Enrico; Salamina, Giuseppe

    2016-01-01

    Si intende qui descrivere il sistema di sorveglianza sugli effetti sulla salute (SpoTT) dell'inquinamento ambientale nelle aree circostanti l'inceneritore di Torino. SPoTT ha 3 linee di attività: 1. monitoraggio epidemiologico degli effetti a breve termine attraverso analisi temporali e misura della correlazione tra livelli giornalieri di emissioni dell'impianto e andamento degli eventi individuati dagli archivi dei dimessi (SDO), di pronto soccorso e di mortalità; sono coinvolti coloro che nel 2013-2018 risiedevano nell'area di ricaduta delle emissioni; 2. sorveglianza epidemiologica degli effetti a lungo termine, stimando tassi standardizzati di mortalità e morbosità; a ogni soggetto è attribuito il valore stimato di esposizione cumulato nel tempo caratteristico della residenza anagrafica; le informazioni sulla salute sono reperite dagli archivi SDO, di mortalità e dai certificati di assistenza al parto; sono studiati due decenni pre-post l'avvio dell'impianto: 2003-2012 e 2013-2022; 3. monitoraggio biologico con misurazione pre-post di metalli, PCDD/F, PCB, OH-IPA; sono coinvolti 196 residenti esposti e 196 di controllo di 35-69 anni, campionati a caso dalle anagrafi comunali; sono effettuate misure di funzionalità endocrina e respiratoria, pressione arteriosa, rischio cardiovascolare; l'esposizione cumulativa sarà stimata per ciascuna persona campionata integrando l'indirizzo di residenza, il tempo di permanenza in ciascun indirizzo e i dati ricavati dai modelli di ricaduta; sarà costituita una biobanca per future indagini di laboratorio; sono coinvolti anche 20 allevatori e i lavoratori dell'impianto. Una quarta linea di attività, non descritta in questo articolo, riguarda il monitoraggio della salute dei lavoratori addetti all'impianto. SPoTT è il primo studio in Italia su inceneritori e salute che adotta un disegno di studio longitudinale di adeguata potenza sia per i residenti sia per i lavoratori. I primi risultati sono attesi nel corso del 2016.

  11. Cutaneous metastasis from lung cancer. Case report.

    PubMed

    Fratus, Giorgio; Tagliabue, Fabio; Mariani, Pierpaolo; Bottazzi, Enrico Coppola; Spinelli, Luisella; Novellino, Lorenzo

    2014-07-21

    Il cancro del polmone rappresenta la patologia maligna maggiormente diagnosticata a livello mondiale. La diffusione metastatica della malattia è piuttosto frequente. Oltre ai classici siti di metastatizzazione (ossea, surreni, fegato, cervello) un sito particolare è rappresentato dalla cute. Il caso presentato riguarda appunto un paziente di 66 anni con metastasi cutanea da neoplasia del polmone. Un uomo di 66 anni, con anamnesi positiva per anuerisma aortico sottorenale, BPCO, cardiopatico e diabetico, giunge alla nostra osservazione per neoplasia del lobo inferiore del polmone sinistro. Dopo un accurato staging preoperatorio, il paziente viene sottoposto a lobectomia inferiore sinistra. L’esito dell’esame istologico è di carcinoma squamocellulare moderatamente e scarsamente differenziato G2-3 pT2bN0. Il paziente viene pertanto inviato al collega oncologo per il regolare follow up. Dopo circa 6 mesi il paziente ritorna alla nostra attenzione per la comparsa a livello del fianco/fossa iliaca di destra di nodulo cutaneo, duro, discromico, dolente ed ulcerato. Le biopsie eseguite, hanno dato esito di carcinoma squamocellulare moderatamente e scarsamente differenziato. Il paziente veniva sottoposto a un TC torace- addome che evidenziava in sede della parete addominale l’assenza d’infiltrazione dei piani muscolo-aponeurotici da parte della neoformazione. Il paziente è stato quindi sottoposto ad intervento chirurgico di asportazione della lesione cutanea. L’esame istologico del pezzo operatorio ha confermato trattarsi di carcinoma squamocellulare metastatico. Le metastasi cutanee da carcinoma del polmone si presentano nel 2,5 - 7,5% dei casi. La sopravvivenza mediana di questi pazienti è di circa 2,9 mesi. L’istotipo maggiormente coinvolto, secondo autori Giapponesi, è l’adenocarcinoma seguito dal carcinoma squamocellulare. Alcuni studi hanno dimostrato la validità dell’approccio chirurgico seguito dalla chemioterapia nei casi di metastasi singole

  12. Surgical approach for ulcerated locally advanced breast cancer. A single Center experience: a retrospective study.

    PubMed

    Laforgia, Rita; Punzo, Clelia; Panebianco, Annunziata; Volpi, Annalisa; Minafra, Marina; Sederino, Maria Grazia

    2017-01-12

    L’obiettivo del nostro studio è la valutazione della strategia chirurgica più idonea nei casi di LABC (Locally Advanced Breast Cancer) in condizioni di ulcerazione e sanguinamento. La diagnosi clinica del LABC prevede nella maggior parte dei casi una massa mammaria estesa associata ad edema, eritema, retrazione e sanguinamento, dolore, superficie cutanea irregolare e coinvolgimento linfonodale. L’intervento chirurgico di scelta per le forme T3-T4 è la mastectomia radicale che rappresenta un trattamento adeguato per il controllo locale della patologia. In caso di forme localmente avanzate e ulcerate, pur essendo forme inoperabili, l’exeresi chirurgica si rende necessaria per una bonifica locale. La presenza di fenomeni di ulcerazione e sanguinamento non rende possibile avviare un trattamento chemioterapico neoadiuvante ed è necessario eseguire interventi chirurgici palliativi. Il trattamento chirurgico stesso richiede mutilazioni ampie ed associate procedure di chirurgia plastica. Spesso per l’estensione della malattia ed il sovvertimento del corpus mammae durante l’exeresi chirurgica della mammella, la sezione su zone esenti da neoplasia non consente la chiusura immediata dei lembi. Abbiamo considerato, su un campione di 288 pazienti affette da carcinoma mammario, 11 donne con forme avanzate fra T4a e T4c (3.8%). E’ stata posta indicazione a trattamento chirurgico perché pazienti provenienti dal Pronto Soccorso con anemizzazione per neoplasie avanzate ulcerate e sanguinanti, non candidabili in prima istanza a chemioterapia neoadiuvante citoriduttiva. Le procedure adoperate per la ricostruzione della mammella sono state in 2 pazienti la rotazione di un lembo muscolo cutaneo, in 4 casi un innesto cutaneo prelevato dalla coscia, in 4 casi è stata utilizzata una matrice dermica biologica - sostituto cutaneo (INTEGRA) che è stata poi sostituita con un successivo innesto cutaneo a distanza di circa 20-30 giorni. Sono state osservate recidive in 2 casi

  13. Underwater Explosion (UWE) Analysis of the ROKS Cheonan Incident

    NASA Astrophysics Data System (ADS)

    Kim, So Gu; Gitterman, Yefim

    2013-04-01

    The underwater explosion (UWE) resulting in the sinking of the South Korean warship, ROKS Cheonan occurred on March 26 2010. Raw data was analyzed from several 3-component stations—Baengyeong-do Korea Meteorological Administration (KMA) station (BAR), Ganghwa KMA station (GAHB), Incheon Incorporated Research Institutions for Seismology (IRIS) station (INCN), the short-period station—Deokjeok-do KMA station (DEI), as well as from the seismo-acoustic array Baengyeong-do Korea Institute of Geoscience and Mineral Resources (KIGAM) station (BRDAR). The ROKS Cheonan incident has been investigated by both the Multinational Civilian-Military Joint Investigation Group (Ministry of National Defense, 2010) and Hong (Bull Seism Soc Am 101:1554-1562, 2011). Their respective methods and conclusions are also presented in this study. One of the main differences between their findings and ours is that we deducted that the fundamental bubble frequency was 1.01 Hz with a subsequent oscillation of 1.72 Hz. Also, in contrast to findings by the MCMJIG and Hong, our analysis shows the first reverberation frequency to be 8.5 Hz and the subsequent one to be ≈25 Hz. The TNT-equivalent charge weight (seismic yield) and seismic magnitude were estimated from an observed bubble frequency of 1.01 Hz and the analytical model of a bubble pulse. From the data analyzed, we deducted that the seismic yield would be about 136 kg of TNT, which is equivalent to the individual yield of a large number of land control mines (LCM) which were abandoned in the vicinity of the ROKS Cheonan incident by the Republic of Korea (ROK) Navy in the 1970s (Ministry of National Defense 2010). Also, whereas both the MCMJIG and HONG estimated the local magnitude at 1.5, our findings came to the conclusion of a local magnitude of approximately 2.04 based on the bubble frequency of 1.01 Hz measured on the vertical component of BAR station data considering the empirical relationship between charge weight (TNT yield) and

  14. [In Process Citation].

    PubMed

    Zhu, Jin-Zhou; Li, Chun-Xiao; Dai, Yi-Ning; Zhao, De-Jian; Fang, Zhi-Yun; Wan, Xing-Yong; Zhu, Hua-Tuo; Wang, Yu-Ming; Yu, Chao-Hui; Li, You-Ming

    2016-03-25

    Introducción: la betatrofina es una novedosa adipoquina que provoca la proliferación de células β pancreáticas e interviene en el metabolismo de los lípidos. Objetivos: el propósito de este estudio es evaluar el papel de la betatrofina en el síndrome metabólico. Método: se llevó a cabo un estudio hospitalario de casos y controles según sexo y edad. El nivel de betatrofina en suero fue evaluado mediante ensayo por inmunoabsorción ligado a enzimas. Se midieron las concentraciones en suero de 12 adipoquinas para evaluar las asociaciones con la betatrofina usando los kits comerciales Adipokine Magnetic Bead Panel. Los análisis estadísticos incluyeron correlación bivariada, análisis de curva ROC y análisis de regresión lineal multivariable. Resultados: el nivel de betatrofina en suero fue más elevado en pacientes con síndrome metabólico (997,36 ± 475,92 pg/ml, p = 0,001) que en los controles (735,35 ± 526,51 pg/ml). Frente al tercil más bajo, el tercil más alto del nivel de betatrofina mostró una asociación con mayor riesgo de síndrome metabólico (odds ratio ajustado = 3,521, intervalo de confianza [IC] 95% [1,191-10,413], p = 0,023). Se desarrolló la curva ROC de betatrofina para pronosticar la presencia de síndrome metabólico (área bajo la curva ROC = 0,682 [95% IC, 0,597-0,767], p < 0,001). Además, la betatrofina mostró correlación con distintos parámetros, como edad (r = 0,286, p < 0,001), índice de masa corporal (r = 0,160, p = 0,046), índice cintura-cadera (r = 0,241, p = 0,002), lipoproteína de alta densidad (r = -0,167, p = 0,037), lipoproteína de baja densidad (r = -0,195, p = 0,015), glucosa plasmática en ayunas (r = 0,266, p = 0,001), hemoglobina A1C (r = 0,314, p < 0,001), índice de resistencia a la insulina mediante HOMA (r = 0,272, p = 0,001) y diversas adipoquinas, entre ellas resistina (r = 0,571, p < 0,001), interleucina-8 (r = 0,435, p < 0,001), factor de necrosis tumoral alfa (r = 0,295, p = 0,011) y

  15. [PRE-OPERATIVE IRON DEFICIENCY IN BARIATRIC SURGERY: DIAGNOSIS AND TREATMENT].

    PubMed

    Magali Sanchez, Angela María; Pampillón, Natalia; Abaurre, Mariela; Omelanczuk, Pablo Esteban

    2015-07-01

    descenso en el post OP (37,5% ± 3,4 y 12,3 g/l p < 0,05). La suplementación con hierro EV en pacientes ferropénicos (n = 9) aumentó la hemoglobina (13,5 g/l ± 0,7) con respecto al pre OP (12,8 g/l ± 1,2; p:0,05), así como la saturación de transferrina y ferritina. Al mes de la cirugía el Hematocrito no tuvo cambios significativos (Hematocrito pre OP: 39%; Hematocrito post OP: 40% p: > 0,05). Discusion:1) Casi el 26% de los pacientes presentan ferropenia en el pre OP. 2) El tratamiento con hierro EV parece ser eficaz para prevenir un descenso de hematocritos y mejorar el metabolismo del hierro en pacientes ferropénicos previos a la cirugía. Los pacientes sin ferropenia al mes de la cirugía mantienen valores normales de hematocritos y metabolismo del hierro sin necesidad de suplementación de hierro.

  16. [Desvenlafaxine and neuropathic pain: additional clinical benefits of a second generation serotonin-noradrenaline reuptake inhibitor].

    PubMed

    Alcantara-Montero, A

    2017-03-01

    Introduccion. La desvenlafaxina es el tercer antidepresivo incluido entre los inhibidores de la recaptacion de serotonina y noradrenalina. Las ultimas guias de practica clinica consultadas coinciden en señalar que los antidepresivos triciclicos, los duales (venlafaxina/duloxetina) y los antiepilepticos gabapentina y pregabalina constituyen los farmacos de primera linea en el tratamiento del dolor neuropatico. El tramadol, los apositos de lidocaina al 5% y los parches de capsaicina al 8% son los farmacos de segunda linea, mientras que los opioides potentes constituirian una tercera linea de tratamiento. La interaccion entre el binomio dolor y depresion es muy habitual y representa la complicacion psicologica mas frecuente en los pacientes con dolor cronico. Desarrollo. Tras una busqueda bibliografica, en este articulo se resumen los datos farmacologicos mas relevantes de la desvenlafaxina y su utilidad en la practica clinica, asi como la bibliografia especifica de este farmaco en el dolor neuropatico y el dolor cronico. Conclusiones. Aunque la evidencia de la desvenlafaxina en el dolor neuropatico es escasa, presenta unas caracteristicas farmacocineticas interesantes, como son no ser sustrato ni actuar sobre la glicoproteina P y tener un metabolismo que practicamente no depende del sistema del citocromo P450, lo que limita el riesgo de interacciones farmacocineticas y los potenciales problemas de tolerabilidad asociados cuando se administra con farmacos que sean inhibidores moderados o potentes del CYP2D6 o con otros sustratos de esta isoenzima. Estas caracteristicas hacen de la desvenlafaxina un antidepresivo distinto y especialmente util en algunos subgrupos de pacientes con dolor cronico (como polimedicados y pacientes con insuficiencia hepatica), donde la depresion comorbida es frecuente.

  17. Whole-body vibration training as complement to programs aimed at weight loss.

    PubMed

    Cristi-Montero, Carlos; Cuevas, María J; Collado, Pilar S

    2013-01-01

    Introducción: El entrenamiento de vibraciones de cuerpo completo (EVCC) ha demostrado ser de gran utilidad para aumentar la masa muscular, el tejido óseo, la potencia muscular, la flexibilidad, y la fuerza, entre otros. No obstante, hasta la fecha es escasa la literatura respecto a sus efectos sobre el metabolismo energético y si esta herramienta podría ser capaz de potenciar la pérdida de peso como complemento a un programa nutricional y/o de ejercicio físico. Objetivo: El objetivo de la presente revisión es analizar los últimos estudios sobre el EVCC con la finalidad de determinar si puede ser un método fiable para complementar los programas orientados a la reducción del peso corporal. Métodos: Se realizó una búsqueda bibliográfica en Pubmed, Scielo y SPORTDiscus, así como una búsqueda manual entre las referencias de los estudios seleccionados. Resultados: El EVCC parece estar vinculado a tres vías relacionadas con la reducción del peso corporal: inhibición de la adipogénesis y reducción de la masa grasa, aumento del gasto energético y aumento de la masa muscular. Tras analizar la literatura, ninguna de las vías propuestas es consistente, y en muchas ocasiones los resultados son contradictorios. Conclusión: Se concluye que es necesario profundizar sobre esta línea de investigación. No obstante, el EVCC parece ser un método seguro y posiblemente tendría beneficios, principalmente sobre la masa muscular, lo que podría promover la pérdida de peso si se combina con un plan nutricional y un programa de ejercicio tradicional.

  18. [In Process Citation].

    PubMed

    Mauro-Martin, Ismael San; De la Calle-de la Rosa, Licia; Sanz-Rojo, Sara; Garicano-Vilar, Elena; Ciudad-Cabañas, María José; Collado-Yurrita, Luis

    2016-02-16

    Introducción: las enfermedades cardiovasculares (EC) constituyen la principal causa de muerte a nivel mundial. La etiología es multifactorial, pueden influir diversos factores como la dieta, los hábitos de vida, el nivel de ejercicio físico o la carga genética. El gran número de genes implicados, así como sus diversas variantes, pueden influir sobre el riesgo de padecer enfermedades cardiovasculares por medio de distintas vías.Objetivo: determinar la relación existente entre diferentes polimorfismos genéticos y el riesgo individual de EC en población infantil y adulta.Métodos: se llevó a cabo una búsqueda bibliográfica utilizando la base de datos PubMed. La búsqueda se limitó a un periodo de diez años y a metaanálisis realizados en humanos.Resultados: se establece relación entre el riesgo de enfermedad cardiovascular y los siguientes polimorfismos genéticos: cromosoma 9p21, apolipoproteína A5, apolipoproteínas E2, E3 y E4, gen PPARG o PPARϒ, genes implicados en el metabolismo lipídico, gen MTHFR, citocromo P450, factor V de coagulación o factor de Leiden (FVL) y gen VKORC.Conclusiones: Se han identificado un gran número de genes relacionados con la enfermedad cardiovascular. La carga genética puede influir de manera directa o indirecta sobre el riesgo cardiovascular, modificando factores de riesgo para enfermedad cardiovascular o actuando sobre la medicación empleada para tratarla.

  19. Prolidase activity and oxidative stress in patients with breast carcinoma A prospective randomized case-controlled study.

    PubMed

    Bayhan, Zulfu; Zeren, Sezgin; Kocak, Cengiz; Kocak, Fatma Emel; Duzgun, Sukru Aydin; Algin, Mustafa Cem; Taskoylu, Burcu Yapar; Yaylak, Faik

    2016-09-19

    Lo stress ossidativo gioca un ruolo importante nella patogenesi delle malattie neoplastiche. La prolidasi è un costituente della matrice metalloproteinasica, gioca un ruolo maggiore nel metabolismo del collagene, nell’accrescimento cellulare e nel rimodellamento strutturale. Una elevata attività prolidasica è stata dimostrata in molti casi di carcinomi. Lo scopo del presente studio è quello di indagare sull’attività sierica della prolidasi, dello stato ossidativo (TOS) ed antiossidativo (TAS) totale, e di valutare il loro rapporto con lo stadio del tumore, delle metastasi linfonodali e della massa neoplastica in pazienti con carcinoma mammario. Per lo studio sono state arruolate 35 pazienti con carcinoma della mammella e 40 soggetti di controllo. Sono stati rilevati i livelli di TAS, TOS e dell’attività prolidasica, calcolando gli indici di stress ossidativo (OSI). Come risultato i livelli di TOS, di OSI e dell’attività prolidasica sono risultati significativamente più elevati nelle pazienti con carcinoma mammario rispetto al gruppo di controllo (rispettivamente (P < 0.001, P < 0.001, P = 0.002). I livelli di TAS sono risultati significativamente inferiori nelle pazienti con carcinoma mammario rispetto al gruppo di controllo (P = 0,016). Sono stati rilevate correlazioni positive tra attività prolidasica, ed i livelli di TOS e di OSI con lo stadio tumorale, le metastasi linfoniodali e le dimensioni del tumore. Negativa è risultata la correlazione tra i livelli di TAS e le dimensioni del tunore, ma nessuna correlazione tra i livelli di TAS e lo stadio del tumore, come pure con l’infiltrazione linfonodale. Si conclude che l’elevata attività prolidasica del siero e lo stress ossidativo possono associarsi col carcinoma mammario. L’accresciuta attività prolidasica può essere messa in relazione con lo stadio e la prognosi del carcinoma mammario.

  20. [Childhood obesity is associated to the interaction between firmicutes and high energy food consumption].

    PubMed

    Estrada-Velasco, Barbara Ixchel; Cruz, Miguel; Garcia-Mena, Jaime; Valladares Salgado, Adan; Peralta Romero, Jesus; Guna Serrano, Maria de Los Remedios; Madrid-Marina, Vicente; Orbe Orihuela, Citlalli; López Islas, Claudia; Burguete-García, Ana Isabel

    2014-12-16

    Introducción: La obesidad es un grave problema de salud pública en México, la Encuesta Nacional de Salud y Nutrición (ENSANUT 2012) reporta una prevalencia de sobrepeso y obesidad en niños de 5 a 11 años de 34.4%, siendo el país con mayor prevalencia a nivel mundial. Investigaciones recientes han sugerido que la microbiota intestinal puede ser factor de riesgo de la obesidad por su influencia en el metabolismo humano. Objetivo: Evaluar si existe asociación entre el perfil de la microbiota intestinal y la obesidad infantil y si esta asociación se modifica dependiendo del patrón de alimentación de una muestra de niños de edad escolar de la Ciudad de México. Metodología y Resultados: Estudio transversal en 1042 niños de 6 a 14 años, a todos se les aplicó cuestionario de actividad física, antecedentes patológicos personales y heredofamiliares de obesidad y diabetes tipo 2. La definición de los patrones de alimentación se realizó por análisis de componentes principales (ACP). La asociación entre microbiota intestinal y sobrepeso/obesidad dependiendo de la dieta se evaluó con modelos de regresión logística, ajustados por factores de confusión. Encontramos que un perfil de abundancia relativa alta de Firmicutes y una abundancia relativa baja de Bacteroidetes aunado a un consumo elevado de dietas ricas en carbohidratos y grasas saturadas se asocia con un mayor riesgo de obesidad. Conclusión: La interacción entre la microbiota intestinal y la dieta, particularmente con alto contenido de grasas y carbohidratos simples incrementa las posibilidades de presentar obesidad.

  1. Prevalence of metilentetrahidrofolate reductase C677T polymorphism, consumption of vitamins B6, B9, B12 and determination of lipidic hydroperoxides in obese and normal weight Mexican population.

    PubMed

    Hernández-Guerrero, César; Romo-Palafox, Inés; Díaz-Gutiérrez, Mary Carmen; Iturbe-García, Mariana; Texcahua-Salazar, Alejandra; Pérez-Lizaur, Ana Bertha

    2013-11-01

    Introducción. El estrés oxidativo es un factor clave en el inicio y el desarrollo de las comorbilidades de la obesidad. La enzima metiltetrahidrofolato reductasa (MTHFR) participa en el metabolismo del folato con la acción de las vitaminas B9 y B12. El gen MTHFR puede presentar un polimorfismo de un solo nucleótido (SNP) en la posición 677 (C677T), que puede promover homocisteinemia asociada a la producción de radicales libres. Objetivo. Determinar la frecuencia del SNP C677T de la MTHFR, evaluar el consumo de vitaminas B6, B9, B12 y determinar la concentración de hidroperóxidos lipídicos (LOOH) en plasma en un grupo de obesos y testigo. Métodos. Se clasificaron 128 mexicanos mestizos de acuerdo a su índice de masa corporal en normopeso (Nw; n=75) y obesidad (ObeI-III; n=53). Se identificó el SNP C677T de la MTHFR mediante la técnica de PCR-RFLP. El consumo de vitaminas B6, B9 y B12 se evaluó mediante una encuesta validada. Se determinaron LOOH como un indicador de estrés oxidativo periférico. Resultados. No hubo diferencia estadística significativa en la frecuencia del polimorfismo C677T entre homocigotos TT en Nw (0.19) y ObeI-III (0.25). La frecuencia del alelo T en Nw fue de 0.45, y 0.51 en el grupo ObeI-III. Los LOOH mostraron diferencia estadística significativa (p.

  2. ENDURANCE TRAINING IN FASTING CONDITIONS: BIOLOGICAL ADAPTATIONS AND BODY WEIGHT MANAGEMENT.

    PubMed

    Vicente-Salar, Néstor; Urdampilleta Otegui, Aritz; Roche Collado, Enrique

    2015-12-01

    Introducción: en la mayoría de las disciplinas deportivas, el deportista debe conseguir unas óptimas condiciones a nivel muscular y metabólico, así como de composición corporal, manteniendo un bajo porcentaje de grasa corporal. En este contexto se han propuesto diferentes protocolos de entrenamiento con el fin de reducir el porcentaje de grasa corporal incidiendo en un aumento de la utilización de las grasas en detrimento del glucógeno. Objetivo: comprobar si el entrenamiento en ayunas favorece el uso de ácidos grasos debido a los bajos niveles de glucógeno, permitiendo mejoras en el rendimiento y en el control del peso a partir de los estudios publicados. Resultados: los protocolos publicados difieren tanto en el periodo de trabajo como en la intensidad del ejercicio, así como respecto al análisis de una gran variedad de marcadores, desde la expresión de genes hasta parámetros circulantes. Discusión: a bajas intensidades de ejercicio aeróbico, los niveles de lipólisis y oxidación de grasas son mayores en el ejercicio en ayunas. Por otro lado, el metabolismo de la glucosa en condiciones de ayuno se adapta en relación al ahorro de las reservas de glucógeno. Finalmente, en condiciones de ayuno, la degradación de proteínas musculares se ve disminuida. Actualmente solo un estudio analiza los cambios en la composición corporal tras un protocolo de larga duración de ejercicio y ayuno, por lo que es necesario realizar más estudios con el fin de demostrar que se trata de una estrategia válida para el control del peso corporal.

  3. MATERNAL AND POST-WEANING EXPOSURE TO A HIGH FAT DIET PROMOTES VISCERAL OBESITY AND HEPATIC STEATOSIS IN ADULT RATS.

    PubMed

    dos Santos Perez, Gabriela; Santana dos Santos, Lucimeire; dos Santos Cordeiro, Gabriele; Matos Paraguassú, Gardênia; Abensur Athanazio, Daniel; Couto, Ricardo David; Bonfim de Jesus Deiró, Tereza Cristina; Manhães de Castro, Raul; Barreto-Medeiros, Jairza Maria

    2015-10-01

    Objetivo: teniendo en cuenta el consumo frecuente de dietas ricas en grasas por las mujeres en edad reproductiva, el objetivo del presente estudio fue investigar los efectos del consumo materno de una dieta alta en grasas durante el periodo perinatal y/o post-destete en el higado y el metabolismo de los lipidos en ratas jovenes. Métodos: ratas hembra Wistar fueron alimentadas durante el embarazo y la lactancia con un alto contenido de grasa (H) o de control (C). La descendencia se asigno a cuatro grupos: Control (CC, n = 11), descendencia alimentada con una dieta de control despues del destete; Control de dieta alta en grasa (CH, n = 10), crias alimentadas con una dieta alta en grasas despues del destete; Alta en grasas de alta en grasa (HH, n = 10), hijos de madres H alimentados con una dieta alta en grasas despues del destete; y Control de alta en grasa (HC, n = 9), hijos de madres H alimentados con dieta de control tras el destete. Resultados y discusión: la ingesta de alimentos no difirio entre los grupos; sin embargo, el peso relativo del tejido adiposo fue mayor en los animales de los grupos HC, HH y CH (p ≤ 0,005). La esteatosis hepatica se encontro en los CH y HH, que tambien presentaban hipercolesterolemia (p ≤ 0,05). Los niveles de las enzimas hepaticas alanina aminotransferasa (ALT) y gamma-glutamil transpeptidasa (GGT) fueron mayores en el grupo de HH, y el nivel de LDL fue mayor en el grupo CH en comparacion con el CC. El consumo de la dieta propicio la obesidad durante los periodos criticos del desarrollo y puede contribuir a la aparicion de obesidad visceral, esteatosis hepatica e hipercolesterolemia en ratas adultas, incluso en ausencia de cambios en la ingesta dietetica.

  4. [Variability in the clinical presentation of Pompe disease in infancy: two case reports and response to treatment with human recombinant enzyme].

    PubMed

    Moreno-Medinilla, Esther; Berzosa-López, Raquel; Mora-Ramírez, M Dolores; Blasco-Alonso, Javier; Martínez-Antón, Jacinto

    2014-12-01

    Introduccion. La enfermedad de Pompe o glucogenosis tipo II es un error innato del metabolismo, de herencia autosomica recesiva, causado por un deficit de la enzima lisosomal alfa-glucosidasa acida (GAA), que ocasiona un acumulo multisistemico de glucogeno. Describimos dos casos de inicio temprano (infantil) con diferentes formas de presentacion. Casos clinicos. El primer caso se trata de un neonato que presento una bradicardia mantenida desde el nacimiento, lo que motivo el estudio cardiologico, en el que se evidencio una hipertrofia biventricular grave. El segundo caso se trata de un niño de 14 meses con retraso motor e hipotonia con arreflexia. En la analitica destacaban una creatincinasa, lactato deshidrogenasa, transaminasa glutamico oxalacetica y transaminasa glutamico piruvica elevadas. El electromiograma mostro signos de afectacion miopatica, y la biopsia muscular, una miopatia vacuolar con deposito de glucogeno. En ambos, la actividad de la GAA estaba disminuida y el analisis genetico del gen GAA evidencio que eran portadores heterocigotos de mutaciones descritas en la enfermedad de Pompe. Iniciaron tratamiento con enzima recombinante humana al mes y a los 18 meses de vida, respectivamente, con mejoria evidente de la miocardiopatia hipertrofica, aunque mas limitada a nivel motor. En la actualidad tienen, respectivamente, 9 meses y 5 años, y este ultimo presenta un nivel III de la escala GMFM (Gross Motor Function Measure). Conclusion. La GAA recombinante humana es la unica opcion terapeutica autorizada para estos pacientes. Los efectos que hemos observado son similares a los descritos en otros casos, con una excelente evolucion de la miocardiopatia hipertrofica y un efecto variable sobre la musculatura esqueletica.

  5. [Prevalence of intolerance to salicylates in patients with nasal polyposis].

    PubMed

    Castilla-Rodríguez, Jaisel Luz; Vargas-Camaño, María Eugenia; Rodríguez-Briceño, Rodrigo Alberto; Galicia-Tapia, Jorge; Castrejón-Vázquez, María Isabel

    2015-01-01

    Antecedentes: la intolerancia a salicilatos se relaciona con la alteración en el metabolismo del ácido araquidónico, desencadenando incremento de cisteinil leucotrienos; puede manifestarse con síntomas respiratorios, cutáneos, sistémicos o asociado con poliposis nasosinusal. Los salicilatos están contenidos en antiinflamatorios, productos cosméticos y alimentos. Objetivo: determinar la prevalencia de la intolerancia a salicilatos en pacientes con poliposis nasosinusal que acuden al Servicio de Inmunología Clínica y Alergia y al servicio de Otorrinolaringología del Centro Médico Nacional 20 Noviembre, ISSSTE. Material y método: estudio observacional, descriptivo, transversal, en el que se incluyeron pacientes con poliposis nasosinusal. El tamaño de la muestra fue de 49 pacientes, las variables se compararon utilizando STATISTICA 8.0. Resultados: la prevalencia de poliposis nasosinusal fue de 4%, fue mayor en el género femenino; sólo 24% de la población se encontraba en un peso ideal, la prevalencia de intolerancia a salicilatos fue de 53%, la prevalencia de la tríada de Samter fue de 31%. Conclusiones: la poliposis nasosinusal es una enfermedad con patrón inflamatorio, su fisiopatología aún no se establece totalmente; en este estudio se encontró relacionada con obesidad y con la persistencia de sinusitis. La complicación más temida es la recurrencia, se ha relacionado con intolerancia a salicilatos; en este estudio se encontró leve incremento de la recurrencia en el grupo de intolerancia, sin diferencia estadísticamente significativa, posiblemente relacionado con el tamaño de la población.

  6. [In Process Citation].

    PubMed

    Wang, Bingsong; Li, Yijun; Wu, Xiaolu; Liu, Qingqing; Tang, Xue; Wang, Zuo

    2016-03-25

    Objetivos: oligoelementos como zinc (Zn), hierro (Fe) y cobre (Cu) tienen una influencia significativa en el mantenimiento de la función inmune y del metabolismo normales; modulan la función immune e influyen en la susceptibilidad del organismo ante infecciones. Pero la relación entre trazas de estos elementos y la bronconeumonía resultó incierta. Métodos: en este estudio fueron incluidos 28 niños con bronconeumonía y 46 niños sanos agrupados por edad. Se determinaron los niveles de Zn, Cu, Fe, calcio (Ca) y/o magnesio (Mg) en el suero de los niños con bronconeumonía y sin ella mediante espectrofotometría de absorción atómica. Resultados: los resultados muestran que varios niveles de microelementos como Zn, Ca, Mg y Fe en el grupo con bronconeumonía son menores que en el grupo control. En el grupo de niños con bronconeumonía el nivel de Ca en el suero está asociado positivamente con el zinc (Zn) (p < 0,05) y el hierro (Fe) (p < 0,05), mientras que hay una correlación positiva entre el cobre (Cu) y el calcio (Ca) (p < 0,05), magnesio (mg) (p < 0,05). Conclusión: el nivel de oligoelemento en el suero puede estar asociado con el riesgo de bronconeumonía entre los niños.

  7. ADIPOQUINAS EN EL NIÑO SANO Y AFECTO DE OBESIDAD

    PubMed Central

    Martos-Moreno, G.A.; Kopchick, J.J.; Argente, y J.

    2015-01-01

    El incremento universal de la prevalencia de obesidad en niños y adolescentes durante las últimas décadas, junto con la evidencia creciente de que el establecimiento de obesidad en etapas precoces de la vida está asociado con un incremento de la prevalencia de comorbilidades y del riesgo de muerte prematura, con gran repercusión económica en los sistemas sanitarios de los países occidentales, ha impulsado la investigación en este área. Estos estudios han remarcado la importante actividad endocrina del tejido adiposo, ejercida por medio de la síntesis y secreción de un gran número de péptidos y citoquinas, denominados adipoquinas. En esta revisión se resume el estado actual de los conocimientos, así como los estudios más relevantes, en relación con la dinámica de secreción de las principales adipoquinas en niños, centrándose en el control de la homeostasis energética, regulación metabólica (fundamentalmente, metabolismo de los hidratos de carbono) e inflamación. Asímismo, se analizan las particularidades de la síntesis, secreción y acciones de las adipoquinas desde el nacimiento hasta la adolescencia, reseñando el efecto que, sobre ellas, ejerce la instauración de la obesidad. PMID:23228441

  8. [Oral magnesium supplementation: an adjuvant alternative to facing the worldwide challenge of type 2 diabetes?].

    PubMed

    Guerrero-Romero, Fernando; Rodríguez-Morán, Martha

    2014-01-01

    Antecedentes: ante la repercusión de la diabetes tipo 2 en la calidad de vida y los altos costos de su tratamiento, es urgente la búsqueda de alternativas para el control metabólico y la prevención primaria de esta enfermedad. Objetivo: revisar la evidencia derivada de estudios de cohortes acerca de la relación entre las concentraciones séricas y la ingesta de magnesio con el riesgo de diabetes tipo 2, y de ensayos clínicos de la eficacia de las sales orales de magnesio en la reducción de la glucemia. Material y métodos: estudio retrospectivo, efectuado con base en la búsqueda de estudios de cohorte mayores de 10 años en MEDLINE, EMBASE, y Cochrane Controlled Trials Register, actualizada al 30 de septiembre del 2013. Resultados: se encontraron siete estudios de cohorte (24,388 personas/ año) que muestran que la ingesta de magnesio disminuye el riesgo de diabetes tipo 2; dos estudios (13,076 personas/año) indican que la baja ingesta de magnesio en la dieta no parece asociarse con el riesgo de diabetes; 1 estudio (8,735 personas/año) demuestra que la hipomagnesemia se asocia con alteraciones del metabolismo de la glucosa. De 11 ensayos clínicos con asignación al azar, 5 estudios en sujetos de riesgo muestran que las sales orales de magnesio reducen la glucemia, y 6 estudios en pacientes con diabetes tipo 2 muestran resultados inconsistentes. Conclusiones: la ingesta de magnesio en la dieta habitual o de sales orales de magnesio es recomendable en la prevención de diabetes. La eficacia de las sales de magnesio en la reducción de la glucemia de pacientes con diabetes tipo 2, es inconsistente.

  9. [Proposal of new trace elements classification to be used in nutrition, oligotherapy and other therapeutics strategies].

    PubMed

    Ramírez Hernández, Javier; Bonete Pérez, María José; Martínez Espinosa, Rosa María

    2014-12-17

    Objetivos: 1) Proponer una nueva clasificación de los oligoelementos fundamentada en el estudio detallado de las investigaciones más recientes sobre los mismos; 2) ofrecer información detallada y actualizada sobre todos los oligoelementos. Resultados: el análisis de todos los resultados de investigación consultados pone de manifiesto que los avances en las técnicas de análisis molecular permiten dilucidar la importancia que presentan ciertos oligoelementos para la salud humana. Se ofrece un análisis detallado de la función catalítica que podrían tener determinados elementos no considerados hasta ahora como esenciales o posiblemente esenciales, gracias al uso de plataformas informáticas que permiten el análisis integrado de datos sobre enzimas. Asimismo se presenta información integrada y actualizada del papel fisiológico, cinéticas y metabolismo, fuentes dietéticas y factores que propician la carencia o la toxicidad de cada uno de los oligoelementos. Conclusiones: La Oligoterapia plantea el uso de oligoelementos catalíticamente activos con fines terapéuticos. La nueva clasificación de oligoelementos planteada en este trabajo será de interés para diversos sectores profesionales: médicos y demás personal sanitario, nutricionistas, farmacéuticos, etc. Así podrán diseñarse nuevas estrategias terapéuticas que permitan paliar la sintomatología de diversas patologías, en particular las enfermedades carenciales y metabólicas.

  10. Ulisse Aldrovandi's Color Sensibility: Natural History, Language and the Lay Color Practices of Renaissance Virtuosi.

    PubMed

    Pugliano, Valentina

    2015-01-01

    Famed for his collection of drawings of naturalia and his thoughts on the relationship between painting and natural knowledge, it now appears that the Bolognese naturalist Ulisse Aldrovandi (1522-1605) also pondered specifically color and pigments, compiling not only lists and diagrams of color terms but also a full-length unpublished manuscript entitled De coloribus or Trattato dei colori. Introducing these writings for the first time, this article portrays a scholar not so much interested in the materiality of pigment production, as in the cultural history of hues. It argues that these writings constituted an effort to build a language of color, in the sense both of a standard nomenclature of hues and of a lexicon, a dictionary of their denotations and connotations as documented in the literature of ancients and moderns. This language would serve the naturalist in his artistic patronage and his natural historical studies, where color was considered one of the most reliable signs for the correct identification of specimens, and a guarantee of accuracy in their illustration. Far from being an exception, Aldrovandi's 'color sensibility'spoke of that of his university-educated nature-loving peers.

  11. Vulvar endometriosis and Nuck canal.

    PubMed

    Mazzeo, Carmelo; Gammeri, Emanuele; Foti, Agata; Rossitto, Maurizio; Cucinotta, Eugenio

    2014-12-29

    L’endometriosi è una patologia non ancora del tutto conosciuta che colpisce il 6-10% della popolazione femminile generare e il 35-50% della popolazione femminile affetta da dolore pelvico e infertilità. La sede più frequente di malattia è rappresentata dall’ovaio e ciò sostiene l’ipotesi patogenetica della mestruazione retrograda. Viene descritto un caso di non comune localizzazione vulvare di endometriosi riscontrata in una paziente precedentemente operata per una cisti di Nuck. La donna aveva notato da qualche mese l’insorgenza di una tumefazione nella regione vulvare che le causava dolore e dispareunia che si accentuavano nel periodo mestruale. Il sospetto clinico di endometriosi non aveva avuto conferma negli esami strumentali preoperatori che non avevano evidenziato alterazioni patognomoniche, nè differenze dei reperti in fase pre mestruale e mestruale. Solo l’esame istologico della neoformazione asportata ha confermato la diagnosi. Inoltre gli Autori con la presente nota desiderano sottolineare come nella patogenesi dell’endometriosi vulvare debba essere tenuta in considerazione la presenza della pervietà del dotto peritoneovaginale o dotto di Nuck. Nel caso clinico descritto, infatti, la paziente era stata sottoposta due anni prima ad asportazione di una cisti di Nuck con obliterazione del dotto peritoneovaginale. Tuttavia già in quella fase clinica poteva essersi determinato un impianto endometriosico, che si era poi evidenziato con la formazione del nodulo in sede vulvare asportato chirurgicamente.

  12. Stump appendicitis: a rare and unusual complication after appendectomy. Case report and review of the literature.

    PubMed

    Papi, Simona; Pecchini, Francesca; Gelmini, Roberta

    2014-04-07

    L’appendicite del moncone rappresenta una rara ma importante complicanza che può fare seguito a un intervento di appendicectomia, sia laparoscopica che laparotomica, e rappresenta un’eventualità nosologica da tenere presente, e da includere nella diagnosi differenziale dell’addome acuto di un paziente già appendicectomizzato. I casi riportati in letteratura non sono numerosi, probabilmente però come risultato di una sottostima. Il caso clinico riportato riguarda un uomo di 43 anni operato tre mesi prima di appendicectomia laparoscopica e ricoverato con un tipico caso di addome acuto. L’ecografia si è dimostrata non efficace per la diagnosi, mentre la TC ha definito con sufficiente chiarezza la situazione, ponendo l’indicazione ad una laparotomia esplorativa, nel corso della quale si è proceduto all’asportazione del residuo appendicolare. L’esame istologico ha poi in seguito confermato la diagnosi di appendicite acuta perforata del moncone. A conclusione si è proceduto ad un’analisi di 87 casi analoghi presenti nella letteratura di lingua Inglese per evidenziare le caratteristiche anatomo-chirurgiche ed anatomo- patologiche dei diversi casi, e l’esperienza diagnostica nella definizione del singolo caso. Si conclude con i suggerimenti tecnici per prevenire l’evenienza di tali “appendiciti” ricorrenti sia con la tecnica laparoscopica che laparotomica, e stimolando la consapevolezza di tale eventualità.

  13. Renal arteriovenous fistula simulating hydronephrosis: A case report.

    PubMed

    Lusenti, T; Fiorini, F; Barozzi, L

    2011-12-01

    Sommario INTRODUZIONE: Tra le fistole arterovenose (FAV) acquisite vi sono quelle che si formano quale complicanza dell’esecuzione di una biopsia renale. CASO CLINICO: Gli autori riportano il caso di una paziente giunta in ambulatorio di ecografia nefrologica per l’esecuzione di un’ecografia dei reni e delle vie urinarie per un’ipertensione sistolica di I grado di recente insorgenza. Negli esami di laboratorio era presente microematuria con proteinuria <0.5 g/24 ore. La funzionalità renale risultava ai limiti inferiori della norma (FG 58 mL/min secondo la formula MDRD). L’esame ecografico evidenziava una formazione anecogena “arboriforme” centropielica a livello del rene sinistro suggestiva per idronefrosi. Il color Doppler mostrava viceversa presenza di flusso turbolento all’interno dell’area anecogena stessa, con flusso arterioso elevato e arterializzazione del flusso venoso all’analisi spettrale. La successiva angiografia renale selettiva confermava il sospetto ecografico di FAV mediorenale sinistra con pseudoaneurisma, conseguente ad una biopsia renale effettuata più di 10 anni prima presso altro Centro. Essendo la paziente in pieno benessere veniva consigliato un più stretto follow-up clinico-ecografico. DISCUSSIONE: Tra le malformazioni vascolari renali di non rara osservazione sono le FAV. Il caso descritto ribadisce l’importanza dell’impiego dell’eco color Doppler (ECD) nel sospetto di uropatia ostruttiva, per diagnosticare una FAV, specialmente nei pazienti già sottoposti a biopsia renale.

  14. Relevance of biotic pathways to the long-term regulation of nuclear waste disposal. Phase I. Final report. Vol. 4

    SciTech Connect

    McKenzie, D.H.; Cadwell, L.L.; Eberhardt, L.E.; Kennedy, W.E. Jr.; Peloquin, R.A.; Simmons, M.A.

    1984-05-01

    Licensing and regulation of commercial low-level waste (CLLW) burial facilities require that anticipated risks associated with burial sites be evaluated for the life of the facility. This work reviewed the existing capability to evaluate dose to man resulting from the potential redistribution of buried radionuclides by plants and animals that we have termed biotic transport. Through biotic transport, radionuclides can be moved to locations where they can enter exposure pathways to man. We found that predictive models currently in use did not address the long-term risks resulting from the cumulative transport of radionuclides. Although reports in the literature confirm that biotic transport phenomena are common, assessments routinely ignore the associated risks or dismiss them as insignificant without quantitative evaluation. To determine the potential impacts of biotic transport, we made order-of-magnitude estimates of the dose to man for biotic transport processes at reference arid and humid CLLW disposal sites. Estimated doses to site residents after assumed loss of institutional control were comparable to dose estimates for the intruder-agricultural scenario defined in the DEIS for 10 CFR 61 (NRC). The reported lack of potential importance of biotic transport at low-level waste sites in earlier assessment studies is not confirmed by order of magnitude estimates presented in this study. 17 references, 10 figures, 8 tables.

  15. Relevance of biotic pathways to the long-term regulation of nuclear-waste disposal. Topical report on reference western arid low-level sites

    SciTech Connect

    McKenzie, D.H.; Cadwell, L.L.; Eberhardt, L.E.; Kennedy, W.E. Jr.; Peloquin, R.A.; Simmons, M.A.

    1982-10-01

    The purpose of the work reported here was to develop an order of magnitude estimate for the potential dose to man resulting from biotic transport mechanisms at a reference western arid low-level waste site. A description of the reference site is presented that includes the waste inventories, site characteristics and biological communities. Parameter values for biotic transport processes are based on data reported in current literature. Transport and exposure scenarios are developed for assessing biotic transport during 100 years following site closure. Calculations of radionuclide decay and waste container decomposition are made to estimate the quantities available for biotic transport. Dose to a man occupying the reference site following the 100 years of biotic transport are calculated. These dose estimates are compared to dose estimates for the intruder-agricultural scenario reported in the DEIS for 10 CFR 61 (NRC). Dose to man estimates as a result of biotic transport are estimated to be of the same order of magnitude as the dose resulting from the more commonly evaluated human intrusion scenario. The reported lack of potential importance of biotic transport at low-level waste sites in earlier assessment studies is not confirmed by the findings presented in this report. These results indicate that biotic transport has the potential to influence low-level waste site performance. Through biotic transport, radionuclides may be moved to locations where they can enter exposure pathways to man.

  16. Usefulness of ileostomy defunctioning stoma after anterior resection of rectum on prevention of anastomotic leakage A retrospective analysis.

    PubMed

    Salamone, Giuseppe; Licari, Leo; Agrusa, Antonino; Romano, Giorgio; Cocorullo, Gianfranco; Falco, Nicolò; Tutino, Roberta; Gulotta, Gaspare

    2016-01-01

    Una delle principali e più temute complicanze della resezione anteriore di retto è stata ed è la deiscenza anastomotica. Solitamente, sia essa una scelta di principio od a discrezione del chirurgo operatore, viene confezionata una ileostomia laterale di sicurezza con lo scopo di prevenire tale circostanza. Scopo di tale studio è stato quello di investigare circa la utilità della stomia laterale di sicurezza quale strumento di prevenzione della deiscenza anastomotica, mettendo a paragone il decorso post-operatorio dei paziente con e senza stomia laterale. Le evidenze hanno portato alla conclusione che il confezionamento della stomia laterale di sicurezza è fattore di protezione non tanto dell’evento deiscenza anastomotica in senso stretto, quanto delle complicanze e della evoluzione clinica della stessa, vedasi ad esempio tasso di ricorrenza di deiscenza/quadro clinico in corso di deiscenza/ tempi di degenza, pur rendendosi necessario sottolineare l’assenza di significatività statistica nel tasso di mortalità nei due gruppi in studio. Cosi detto appare dunque sinottico affermare che il confezionamento di ileostomia laterale di sicurezza in corso di resezione anteriore di retto non determina una diretta azione sull’evento “deiscenza anastomotica” né “morte”, purtuttavia modifica certamente in positivo il decorso clinico ed evolutivo dell’evento “deiscenza anastomotica”.

  17. Management of colovesical and colovaginal diverticular fistulas Our experience and literature reviewed.

    PubMed

    Marcucci, Tommaso; Giannessi, Sandro; Giudici, Francesco; Riccadonna, Sara; Gori, Agnese; Tonelli, Francesco

    2014-10-03

    fistole enteriche. Il tasso d’incidenza delle fistole enteriche nella malattia diverticolare è di circa il 2-4% e può raggiungere il 20% nei pazienti sottoposti a chirurgia. La più comune fistola enterica è la colovescicale (60%) seguita dalla colovaginale (20%). Le fistole diverticolitiche colovescicali e colovaginali tendono a non chiudersi spontaneamente e un trattamento medico conservativo è spesso inefficace. Precedenti studi hanno evidenziato elevati tassi di mortalità (fino al 75%) in pazienti con fistole colovescicali non trattati chirurgicamente. Quando possibile, la chirurgia deve essere considerata il trattamento di scelta. Numerosi lavori hanno suggerito che la resezione del tratto di colon patologico è essenziale per ridurre il rischio di fistole recidive e rappresenta il “gold standard” della chirurgia. Le opzioni chirurgiche sono la procedura in one-stage, in two-stage e in three-stage. In elezione e nella maggior parte dei casi Hinchey I e II non c’è evidenza che le procedure in più tempi abbiano risultati migliori di quella in one-stage. La letteratura ha ampiamente dimostrato come la tecnica in onestage con resezione colica e anastomosi primaria è fattibile ed efficace nella maggioranza dei casi. L’uso di una stomia di protezione associata all’anastomosi primaria si è dimostrato utile nel prevenire l’anastomotic leakage. L’intervento di Hartmann o la procedura in three-stage sono indicati nei casi di diverticolite complicata in stadio III e IV di Hinchey. L’intervento in three-stage è raramente eseguito, grazie al miglioramento negli anni della tecnica chirurgica, dei devices usati e della terapia intensiva e antibiotica perioperatoria. Il trattamento dell’organo fistolizzato può variare in base alle dimensioni della fistola. In alcuni casi, il difetto può essere di dimensioni talmente piccole da non essere visibile. Per quanto riguarda il difetto vescicale, questo può essere, nella maggior parte dei casi

  18. [Communication denied: a pilot study on critical relationship in nursing].

    PubMed

    Cotichelli, Giordano

    2014-01-01

    INTRODUCTION. In letteratura sono pressoché assenti studi sula comunicazione infermieristica quando viene negata, ciò fa sorgere il quesito sul perché rifuggire la relazione con il paziente. OBIETTIVI. Valutare le criticità nella comunicazione infermieristica al fine di costruire una base analitica per uno studio più approfondito. MATERIALI E METODI. Osservazione partecipata (cover) durante uno stage di tirocinio, utilizzando un diario dell’osservazione e prendendo in esame il contesto di lavoro e relazionale di un reparto internistico. RISULTATI. Nella maggioranza dei casi si rifugge la comunicazione, riducendo i tempi di contatto con i pazienti, in altri la si ricerca anche quando non espressamente richiesta dal paziente. CONCLUSIONI. Fuggire la relazione può essere un indicatore di insicurezza professionale. L’Altro significativo cui si nega la relazione, diventa lo specchio in cui il professionista ritrova le sue debolezze. Considerare questi elementi favorisce la dimensione terapeutica. Lo studio si rivela elemento di partenza potenziale per un lavoro che possa avere maggior peso con un campione più ampio e in contesti più articolati.

  19. Medical applications of synchrotron radiation at the SYRMEP beamline of ELETTRA

    NASA Astrophysics Data System (ADS)

    Abrami, A.; Arfelli, F.; Barroso, R. C.; Bergamaschi, A.; Billè, F.; Bregant, P.; Brizzi, F.; Casarin, K.; Castelli, E.; Chenda, V.; Dalla Palma, L.; Dreossi, D.; Fava, C.; Longo, R.; Mancini, L.; Menk, R.-H.; Montanari, F.; Olivo, A.; Pani, S.; Pillon, A.; Quai, E.; Ren Kaiser, S.; Rigon, L.; Rokvic, T.; Tonutti, M.; Tromba, G.; Vascotto, A.; Venanzi, C.; Zanconati, F.; Zanetti, A.; Zanini, F.

    2005-08-01

    The main purpose of the SYRMEP (SYnchrotron Radiation for MEdical Physics) research team is the investigation and development of innovative techniques for medical imaging. A dedicated beamline has been built at ELETTRA to evaluate the effectiveness of synchrotron-based techniques in medical radiology with particular interest to mammography, and more in general, to the imaging of biological and biomedical samples, either in planar or tomographic set-ups. Taking advantage of the high intensity and high spatial coherence of Synchrotron Radiation (SR), phase sensitive techniques such as Phase Contrast (PhC) and Diffraction Enhanced Imaging (DEI) can be applied. After successful studies carried out on test objects and in vitro samples, the research in mammography is aiming at in vivo clinical trials. For this purpose, the layout of the SYRMEP beamline has been substantially modified and the safety system has been completely redesigned to guarantee the compliance with current radiation protection guidelines. In the present paper, the main characteristics of the beamline and an overview of the results obtained in different contexts of biomedical imaging are presented. Moreover, the status of the project for clinical mammography is outlined.

  20. Sonnet XXX: Love, dignity, and dying.

    PubMed

    Ely, E Wesley

    2016-05-01

    All of us in medicine who care for patients who are chronically critically ill, dying of incurable illnesses, will be faced with discussions about the value of their lives and about the appropriateness of ongoing supportive care. Such discussions are good and true, and they must always be done within the context of the sanctity of every human life and the promise of God that we are His children, each and every one of us. In this article, I explore the end-of-life path of a patient with amyotrophic lateral sclerosis (ALS) and the courageous faith that she demonstrated in the face of her illness. I explore with you, the reader, the hard-core conversations that took place at her bedside and their meaning in light of Catholic moral teaching. This story is not meant to indicate that we should always do all interventions at all times for all patients. That would be a teaching counter to Evangelium vitae. This story is meant to help you think through the path of your patients and of you as a physician or other type of healthcare professional in serving your patients. Primum non nocere. Ad majorem Dei gloriam.

  1. Pneumatic positioning and mesh fixation in laparoscopic ventral/incisional hernia repair. New surgical technique and a new device.

    PubMed

    Darecchio, Antonio; Bocchi, Paolo; Kukleta, Jan F

    2015-01-01

    Oggetto di questa pubblicazione è la descrizione di una nuova tecnica chirurgica per la riparazione videolaparoscopica di laparoceli ed ernie della parete addominale anteriore. Tale tecnica è strettamente dipendente dall’utilizzo di un nuovo strumento pneumatico per il posizionamento della protesi. Attualmente esistono in commercio svariati tipi di protesi intraperitoneali con valide caratteristiche strutturali. Tuttavia lo scoglio concettuale rimane sui metodi e sui mezzi di fissaggio delle protesi. I mezzi meccanici di qualsiasi conformazione per il fatto stesso di essere dei mezzi meccanici (spirali metalliche ancorette e viti) espongono al pericolo di danno iatrogeno le strutture vascolari nervose che possono incontrare nel loro percorso. La nuova tecnica proposta mira alla perfetta distensione delle protesi per utilizzo intraperitoneale ed ai loro ottimale fissaggio con adesivo chirurgico in condizioni di sicurezza per le strutture circostanti. Tale tecnica è stata eseguita su cadavere di suino* con protesi intraperitoneali di poliestere-gel-collageno e cyanoacrylate come adesivo chirurgico ma non è esclusa la fattibilità con altri tipi di colle, di protesi, protesi auto-adesive già esistenti in commercio o che potrebbero essere appositamente prodotte.

  2. Integrating methods for the environmental sustainability: the SPIn-Eco Project in the Province of Siena (Italy).

    PubMed

    Pulselli, Federico M; Ciampalini, Francesca; Leipert, Christian; Tiezzi, Enzo

    2008-01-01

    This paper shows how different methods can be integrated in order to provide an organic evaluation of the environmental sustainability at the territorial level. A territory is a complex, dynamic and open system where a population develops, uses resources, produces goods and services, consumes, depletes and finally obtains economic results. All these elements characterise human behaviour, which can be monitored, measured and compared to the capacity of the environment to sustain it in the long run. The SPIn-Eco Project for the Province of Siena (Italy) is described as an example of an environmental sustainability assessment of an area, and its methods (Ecological Footprint, Greenhouse Gas Inventory, Extended Exergy Analysis, Emergy Evaluation, Life Cycle Assessment (LCA) and Remote Sensing) are briefly introduced. This Project has been proposed and funded by the most important provincial administrative and financial institutions in the territory (the Administration of the Province of Siena and the Monte dei Paschi Foundation, respectively), and was designed and realised in 4 years (2001-2004) by a research team coordinated by the University of Siena.

  3. A comparison of two questionnaires on Informed Consent for extended criteria liver donors.

    PubMed

    Bruzzone, Paolo; Giannarelli, Diana

    2015-01-01

    Un questionario riguardante il consenso informato del ricevente per i cosiddetti donatori marginali di fegato (“extended criteria donors”-ECD) è stato inviato, previa approvazione del Comitato Etico, via e-mail ai membri di 2 società scientifiche, ELPAT(Ethical,Legal and Psychologic Aspects of Organ Transplantation) ed ELITA (European Liver and Intestine Transplant Association)-ELTR(European Liver Transplant Registry). I risultati sono stati pubblicati in diversi lavori apparsi su Transplantation Proceedings. Analizzando statisticamente le tabelle negli articoli 2011 ELPAT e 2013 ELITA, nel lavoro più recente meno Centri Trapianto di fegato (LTC) hanno considerato l’età fino a 80 anni (p<.002) e SGOT>90 IU (p<.02), o tutti i criteri insieme (p<.0001), come indicatori di donatore marginale. Ciò potrebbe riflettere il fatto che nel tempo i LTC sono divenuti meno selettivi, a causa della crescente mortalità dei pazienti in lista di attesa. Considerando che in tutti i nostri studi abbiamo riscontrato un notevole ricorso agli ECD, è necessario che i pazienti ricevano tutte le informazioni che vogliano richiedere sia al momento dell’iscrizione in lista di attesa, sia quando il fegato di un donatore venga effettivamente loro proposto. E’ anche possibile creare una lista di attesa separata, per pazienti che non accettano ECD: tale scelta però ritarda in modo inevitabile il trapianto e quindi, potenzialmente, aumenta la mortalità in lista di attesa.

  4. Physical and chemical investigations on natural dyes

    NASA Astrophysics Data System (ADS)

    Acquaviva, S.; D'Anna, E.; de Giorgi, M. L.; Della Patria, A.; Baraldi, P.

    2010-09-01

    Natural dyes have been used extensively in the past for many purposes, such us to colour fibers and to produce inks, watercolours and paints, but their use declined rapidly after the discovery of synthetic colours. Nowadays we witness a renewed interest, as natural dyes are neither toxic nor polluting. In this work, physical and chemical properties of four selected dyes, namely red (Madder), yellow (Weld and Turmeric) and blue (Woad) colours, produced by means of traditional techniques at the Museo dei Colori Naturali (Lamoli, Italy), have been investigated. The chromatic properties have been studied through the reflectance spectroscopy, a non-invasive technique for the characterisation of chromaticity. Reflection spectra both from powders and egg-yolk tempera models have been acquired to provide the typical features of the dyes in the UV-vis spectral range. Moreover, to assess the feasibility of laser cleaning procedures, tempera layers were investigated after irradiation with an excimer laser. Micro Raman spectroscopy, Scanning Electron Microscopy and Energy Dispersive X-Ray analyses have complemented the survey, returning compositional and morphological information as well. Efforts have been made to give scientific feedback to the production processes and to support the research activity in the restoration of the artworks where these dyes were employed.

  5. A BGO-CsI(Tl) phoswich: A new detector for X- and γ-ray astronomy

    NASA Astrophysics Data System (ADS)

    Costa, E.; Massaro, E.; Piro, L.

    1986-03-01

    The BGO pulse decay time, similar to that of NaI(Tl), allows the use of this high-Z scintillator as phoswich component instead of the largely employed NaI(Tl). We have verified the feasibility of this new type of detector for possible use in X- and γ-ray astronomy experiments. Measurements on two laboratory prototypes of BGO-CsI(Tl) phoswich have shown a remarkably good pulse-shape discrimination and excellent linearity performances across a wide energy interval (60-2000 keV). The only penalty is a slight reduction in resolution (essentially due to the poor light yield of BGO when compared to NaI), largely compensated by the high photopeak efficiency, even for small BGO thickness. We have also investigated the deviation of BGO from a pure proportional relationship between pulse height and photon energy, which turns out to be opposite to that of NaI(Tl). Now at Istituto TE.S.R.E., CNR, Via dei Castagnoli 1, 40126 Bologna, Italy.

  6. Amarone: a modern wine coming from an ancient production technology.

    PubMed

    Paronetto, Lanfranco; Dellaglio, Franco

    2011-01-01

    Amarone wine is a renowned dry red wine produced in Valpolicella (Verona, Northern Italy). It is made from local grapes varieties (Corvina, Rondinella, and Molinara) that are slowly dried under natural conditions during the fall into winter. After the postharvest drying, carried out for several weeks in dedicated lofts called fruttaio, the grapes are vinified: crushed, given prefermentative cold maceration, undergo alcoholic fermentation on the skins, malolactic fermentation, and finally maturation. The partially dried grapes are traditionally crushed during the second half of January to February. Because cellar conditions are unfavorable for either alcohol or malolactic fermentation, selected microbial cultures (yeasts and malolactic bacteria) are often necessary to correctly manage fermentation. The progress of both fermentation processes needs constant surveillance. During maturation conducted in vessels or wooden containers (tonneau in durmast oak), clarification and stabilization lead to improvements in quality. Product specifications require that Amarone not be bottled before the wine has been aged for 2years (Anonymous (2010). Disciplinare di produzione dei vini a denominazione di Origine Controllata e Garantita "Amarone della Valpolicella". Gazzetta Ufficiale della Repubblica Italiana. Serie generale n. 84. April 12). Amarone achieved its DOCG (Controlled and Guaranteed Denomination) status in 2010.

  7. Cosmogenic radioisotopes in Gebel Kamil meteorite

    NASA Astrophysics Data System (ADS)

    Taricco, C.; Colombetti, P.; Bhandari, N.; Sinha, N.; Di Martino, M.; Vivaldo, G.

    2012-04-01

    Recently a small (45 m in diameter) and very young (< 5,000 years) impact crater was discovered in Egypt (Folco et al., 2010, 2011); it was generated by an iron meteorite named Gebel Kamil (Meteoritical Bulletin No. 98, Weisberg et al. 2010). During systematic searches, many specimens were found in the area surrounding the crater. We present the gamma-activity measurement of a 672 g fragment using a highly selective Ge-NaI spectrometer operating at Monte dei Cappuccini Laboratory (IFSI, INAF) in Torino, Italy. This apparatus allows to reveal the radioisotope activity generated by cosmic rays in the meteoroids as they travel through the interplanetary space before falling on the Earth. From the 26Al activity measurement and its depth production profiles, we infer (i) that the radius of the meteoroid should be about 1 m, constraining to 30-40 ton the range of pre-atmospheric mass previously proposed and (ii) that the fragment should have been located deeply inside the meteoroid, at a depth > 0.7 m. The 44Ti activity is under the detection threshold of the apparatus; using the depth production profiles of this radioisotope and its half-life T1/2 = 59.2 y, we deduce an upper limit to the date of fall.

  8. STUDENT AWARD FINALIST: Study of Self-Absorbed Vacuum Ultraviolet Radiation during Pulsed Atmospheric Breakdown in Air

    NASA Astrophysics Data System (ADS)

    Laity, George; Fierro, Andrew; Hatfield, Lynn; Neuber, Andreas

    2011-10-01

    This paper describes recent experiments to investigate the role of self-produced vacuum ultraviolet (VUV) radiation in the physics of pulsed atmospheric breakdown. A unique apparatus was constructed which enables the detailed exploration of VUV light in the range 115-135 nm, which is emitted from breakdown between two point-point electrodes in an air environment at atmospheric pressure. Time-resolved diagnostics include VUV sensitive photomultipliers, intensified CCD imaging, optically isolated high voltage probes, and fast rise-time Rogowski current monitors. Temporally resolved spectroscopy from air breakdowns revealed VUV emission is released during the initial streamer phase before voltage collapse, with the majority of the emission lines identified from various atmospheric gases or surface impurities. Imaging of VUV radiation was performed which conserved the spatial emission profile, and distinct differences between nitrogen and oxygen VUV emission during onset of breakdown have been observed. Specifically, the self-absorption of HI, OI, and NI lines is addressed which elucidates the role of radiation transport during the photon-dominated streamer breakdown process. Supported by AFOSR, NASA / TSGC, DEPS, and IEEE DEIS.

  9. Innovative technique for large septal perforation repair and radiological evaluation.

    PubMed

    Mocella, S; Muia, F; Giacomini, P G; Bertossi, D; Residori, E; Sgroi, S

    2013-06-01

    La perforazione del setto nasale ha cause molteplici: traumatiche, iatrogene, infettive, degenerative, da abuso di vasocostrittori, da uso di cocaina e di recente anche da chemioterapici antineoplastici. Le perforazioni sono altresì classificate in funzione delle dimensioni e della tipologia del deficit cartilagineo o osteocartilagineo e della sede anteriore, mediana e posteriore. Molteplici tecniche di riparazione chirurgica del danno sono state proposte nel tempo e vengono riassunte nel presente lavoro per tipologia di approccio; i risultati conseguiti, sono soddisfacenti per le perforazioni di piccole e medie dimensioni, ma nelle grandi perforazioni non garantiscono sempre la permanente obliterazione del difetto. Spesso si rende necessario l'utilizzo di tessuti prelevati all'interno delle fosse nasali come i turbinati o il prelievo di cartilagine da altre sedi donatrici come l'orecchio o la costa; le varie tecniche vengono illustrate alla luce della più recente letteratura. Gli Autori hanno valutato i pazienti osservati negli ultimi 8 anni e i risultati chirurgici conseguiti in particolare considerando, gli approcci chirurgici effettuati in approccio aperto o chiuso, endoscopico ed i materiali impiegati. Gli autori propongono tra le varie tecniche impiegate in questa serie di pazienti, una tecnica innovativa utilizzabile con successo in molti dei casi considerati di perforazione settale iatrogena che prevede l'utilizzo del gibbo osteocartilagineo quale sede donatrice, nonché la rinosettoplastica riduttiva quale scelta mirata per ottenere agevolmente lembi di scorrimento mucopericondrale e talora produrre anche un miglioramento estetico morfologico.

  10. Determination of quality parameters in apple `Smoothee Golden Delicious' using backscattering laser imaging

    NASA Astrophysics Data System (ADS)

    Lafuente, Victoria; Val, Jesús; Urzola, Concha; Negueruela, Ignacio

    2013-11-01

    The objective of this study was to evaluate in `Smoothee Golden Delicious' apples, the use of backscattering images as a non-destructive method to estimate some quality parameters during the ripening process of fruits. In this experiment, 208 apples were collected from an experimental orchard of the Estación Experimental de Aula Dei (CSIC) in Zaragoza (Northeastern, Spain). Backscattering images were kept from samples picked up every 15 days during 7 months until harvest. In the same fruits, soluble solids contents (SSC) and firmness were measured by traditional destructive methods. The light source was a solid state laser diode module emitting at three different spectral bands (670, 785 and 980 nm) PLS calibration methods were used to create the statistical model to predict SSC and firmness. Good results were obtained when PLS calibration was applied to Feret diameter corresponding at different levels of gray. The Rcv2 values were 0.87 for firmness and 0.93 for SSC, which are higher than other reported in the literature for the same commodity.

  11. A set of descriptors for identifying the protein-drug interaction in cellular networking.

    PubMed

    Nanni, Loris; Lumini, Alessandra; Brahnam, Sheryl

    2014-10-21

    The study of protein-drug interactions is a significant issue for drug development. Unfortunately, it is both expensive and time-consuming to perform physical experiments to determine whether a drug and a protein are interacting with each other. Some previous attempts to design an automated system to perform this task were based on the knowledge of the 3D structure of a protein, which is not always available in practice. With the availability of protein sequences generated in the post-genomic age, however, a sequence-based solution to deal with this problem is necessary. Following other works in this area, we propose a new machine learning system based on several protein descriptors extracted from several protein representations, such as, variants of the position specific scoring matrix (PSSM) of proteins, the amino-acid sequence, and a matrix representation of a protein. The prediction engine is operated by an ensemble of support vector machines (SVMs), with each SVM trained on a specific descriptor and the results of each SVM combined by sum rule. The overall success rate achieved by our final ensemble is notably higher than previous results obtained on the same datasets using the same testing protocols reported in the literature. MATLAB code and the datasets used in our experiments are freely available for future comparison at http://www.dei.unipd.it/node/2357.

  12. Detailed view into the dynamics of the Late Miocene glaciation episode that accompanied terrestrial evolution

    NASA Astrophysics Data System (ADS)

    Tzanova, A.; Herbert, T.; Lawrence, K. T.; Peterson, L.; Kelly, C. S.

    2015-12-01

    We focus on the period of ~ 9 - 5 Ma when an episode of notably cool temperatures corresponds to evidence of high latitude Northern Hemisphere glaciation and mid-latitude terrestrial evolution. Alkenone-based sea surface temperatures (SST) from six globally distributed sites: ODP Sites 907 and 982 in the North Atlantic, ODP Site 1088 in the South Atlantic and ODP Sites 883, 884 and 887 in the North Pacific, and the Monte dei Corvi marine section in the Mediterranean unequivocally establish a dramatic, Late Miocene cold episode that persisted over approximately 2.5 Myr. In this work we establish the timing and synchronization of temperature decrease as well as rebound at orbital timescales. All sites were notably warmer than their modern annual average at ~9 Ma and exhibit sustained cooling beginning at ~8 Ma. SSTs rebound close to ~5.9 Ma at most locations suggesting that the cooling trend that began in the Late Miocene slowed down or even reversed in some locations in the Pliocene. The newly reconstructed SSTs highlight the role of cooling and an increase in equator to pole temperature gradients in terrestrial evolution at this pivotal time.

  13. Towards an integrated model of nursing competence: an overview of the literature reviews and concept analysis.

    PubMed

    Caruso, Roberto; Fida, Roberta; Sili, Alessandro; Arrigoni, Cristina

    2016-01-01

    Introduzione: La competenza è un elemento fondamentale quando si misura la capacità di infer- mieri o studenti di fornire assistenza infermieristica, ma non vi è consenso su ciò che realmente sia la competenza. Questo studio si propone di indagare i significati e i modelli di competenza infermieristica. Metodo: L’overview delle revisioni della letteratura e delle concept analysis è stata effettuata attraverso una ricerca su Pubmed, Cinahl e PsychINFO dal gennaio 2005 a settembre 2014, che includeva parole chiave come: Modello di competenza; Competenza professionale; Competenza infermieristica; Competenza. Risultati: Sono stati inclusi un totale di 14 articoli, provenienti dalla letteratura infermieristica sia in ambito formativo che clinico. È stato possibile individuare alcuni temi comuni negli arti- coli inclusi: la descrizione dei determinanti di competenza; la confusione intorno al concetto di competenza; la carenza nella valutazione delle competenze; la carenza nell’operazionalizzare il concetto di competenza. Conclusioni: I risultati forniscono una panoramica che, arricchita dalla letteratura proveniente dagli studi organizzativi, costituiscono la base concettuale di un modello integrato di compe- tenza infermieristica. Ulteriore ricerca empirica è necessaria per verificare le assunzioni teoriche.

  14. Virtual unrolling and deciphering of Herculaneum papyri by X-ray phase-contrast tomography

    PubMed Central

    Bukreeva, I.; Mittone, A.; Bravin, A.; Festa, G.; Alessandrelli, M.; Coan, P.; Formoso, V.; Agostino, R. G.; Giocondo, M.; Ciuchi, F.; Fratini, M.; Massimi, L.; Lamarra, A.; Andreani, C.; Bartolino, R.; Gigli, G.; Ranocchia, G.; Cedola, A.

    2016-01-01

    A collection of more than 1800 carbonized papyri, discovered in the Roman ‘Villa dei Papiri’ at Herculaneum is the unique classical library survived from antiquity. These papyri were charred during 79 A.D. Vesuvius eruption, a circumstance which providentially preserved them until now. This magnificent collection contains an impressive amount of treatises by Greek philosophers and, especially, Philodemus of Gadara, an Epicurean thinker of 1st century BC. We read many portions of text hidden inside carbonized Herculaneum papyri using enhanced X-ray phase-contrast tomography non-destructive technique and a new set of numerical algorithms for ‘virtual-unrolling’. Our success lies in revealing the largest portion of Greek text ever detected so far inside unopened scrolls, with unprecedented spatial resolution and contrast, all without damaging these precious historical manuscripts. Parts of text have been decoded and the ‘voice’ of the Epicurean philosopher Philodemus is brought back again after 2000 years from Herculaneum papyri. PMID:27265417

  15. Chromosomenindividualität or Entmischung? The debate between Paolo Della Valle and Edmund B. Wilson.

    PubMed

    Volpone, Alessandro

    2015-01-01

    At the beginning of the twentieth century, the Italian cytologist Paolo Della Valle developed a theory of instable chromosomes (teoria dei cromosomi labili). He radically criticized the so-called Sutton-Boveri hypothesis (Martins and Martins, Genetics and Molecular Biology, 22:261-271, 1999), focusing on numerical constancy in the species and individuality. On the basis of bibliographical review and personal observations, he maintained that the chromosomes were neither stable bodies, nor permanent structures, but transitory cellular materials, resulting from the periodical rearrangement of the chromatin during the cell division. German and English-speaking biologists reacted. The paper shows some content of the argumentations used by Thomas H. Montgomery and especially Edmund B. Wilson. The discussion was characterized by the same data which is interpretedby different scholars in different ways. And the point is that no one of them had the decisive test to demonstrate his own point of view. Wilson simply invoked on his behalf a certain 'common sense', defending at least a 'high degree of constancy'. The debate waned along with the reception of Morgan's chromosome theory of heredity, but only the advent of molecular biology definitively stated the nature of chromosomes as permanent structures of the cell.

  16. [On Academics and Academicians. Historical sketch].

    PubMed

    de Micheli-Serra, Alfredo

    2003-01-01

    First Academies originated in Italy at the beginnings of the Renaissance. Their works were of encyclopedic extent. Regarding to scientific academies, the first was the "Accademia dei Lincei" founded in Rome on August 17, 1603, due to the initiative of four young men; three naturalists and a physician. Later, several distiguished scientists were admitted, such as Giambattista della Porta, inventor of the dark chamber (1610) and Galileo Galilei (1611). This Academy sponsored the publication of a compendium of Francisco Hernández manuscripts, prepared by the Italian physician Antonio Nardo Recchi. Many years later, other scientific academies arose, such as the "Accademia del Cimento", established in 1657 in Florence and inspired by Galilean thought. In 1662, the "Royal Society" of London, was formally recognized, following Bacon's empirical line, and in 1666 the "Académie Royale des Sciences" was created in Paris, which followed the mechanicist orientation of Descartes. These scientific societies aspired to become centers of information and exchange ideas. Therefore, the "Philosophical Transactions" in London and the "Journal des Savants" in Paris began to be published in 1665. Both publications often included medical articles and notes. Regarding New Spain, the worthy "Academia médico-quirúrgica" of Puebla, mentioned since 1802, must be considered. In independent Mexico, two successive medical academies were established that paved the way for our National Academy of Medicine (1864). This society, since its birth, has been publishing the "Gaceta Médica de México", dean of the Mexican medical journals.

  17. The heritage of Dr Dimitrija Demeter in te MaZuranić-Brlić-RuZić memorial library and collection.

    PubMed

    de Canziani Jaksic, Theodor

    2008-01-01

    The collections of the MaZuranić-Brlić-RuZić Memorial Library and Archive in Rijeka contain in addition to the libraries of Ivan, Antun and Matija Mazuranic and of Baron Kuslan, books from the library of Dimitrija Demeter. This Graeco-Croatian man of letters and doctor of medicine was the first modern Croatian playwright. Artefacts, paintings and furniture of the Demeter family are included in the collection, as well as books. Dimitrija Demeter (1811-1872), the son of Afratia and Theodor Demeter, was born into an affluent merchant family in Zagreb in 1811. His two sisters were to marry respected men from Croatian political and cultural life and his brothers became successful business men and founders of Lloyd Triestino. Dimitrija, however, initially devoted himself to science, studying at the medical faculty in Padua, where he graduated in 1834. In 1836 he received his doctorate, on the theme of meningitis. He later became one of the leading figures of the Croatian National Awakening. His main contributions were as an editor and playwright and he is widely regarded as the founder of modern Croatian drama. Not only did he write the plays 'The Field of Grobnik' and 'Teuta', publish articles and edit 'Danica', but he was a driving force behind, and promoter of, the Croatian theatre on St Mark's Square in Zagreb. A portrait of Dimitrija Demeter can still be seen in the Galileo Chamber (dei magnifici quaranta) at the University of Padua, immediately behind the famous Galileo Galilei platform.

  18. Cranial trauma in iron age Samnite agriculturists, Alfedena, Italy: implications for biocultural and economic stress.

    PubMed

    Paine, R R; Mancinelli, D; Ruggieri, M; Coppa, A

    2007-01-01

    The Samnites are an Iron Age protohistoric people from the central region of Italy. The skeletal remains are from the Alfedena necropolis, 6th through 5th centuries B.C. Macchiarelli et al. (Antropologia Contemporanea 4 (1981) 239-243) were the first to report on cranial trauma for this population, presenting four cases with extreme injuries. We re-examined this well documented skeletal population for additional examples of trauma. Previously unexamined remains from Alfedena, excavated at the turn of the 20th century, are also included in our analysis (Mariani. 1901. "Aufidena", ricerche archeologiche e storiche del Sannio settentrionale. Roma: Acc Naz Dei Lincei). Of the 209 adult crania examined, 12.9% of them exhibited trauma. Analysis of location and frequency of cranial trauma revealed that cranial injuries to the head appear to originate from all directions. The high rate of cranial trauma underscores the violent circumstances experienced during the Iron Age protohistoric period of central Italy. Males are much more likely to exhibit cranial injury than females (P = 0.009). We conclude that the injuries received by Samnite male farmer-warriors occurred while defending pastoral-agricultural resources. Trauma rates are similar for some Iron Age populations and not for others. Behavior associated with violence during the Iron Age period can not be generalized for all populations found in Italy.

  19. The role of plastic surgeon in complex cephalic malformations. Our experience.

    PubMed

    Chiumariello, Stefano; Del Torto, Giuseppe; Guarro, Giuseppe; Alfano, Carmine

    2014-01-01

    Le malformazioni complesse del distretto cefalico comprendono tutta una serie di anomalie di sviluppo che oltre a presentare una notevole difficoltà classificativa e di inquadramento, comprendono forme che sono talora di stretta pertinenza specialistica. La correzione delle malformazioni craniofacciali fa ricorso ad una disciplina chirurgica particolarmente esigente, che deve associare una formazione chirurgica di base con un apprendimento delle tecniche specifiche per il territorio craniofacciale e una conoscenza della patologia malformativa. L’eziologia malformativa pone il chirurgo davanti a problemi specifici, dominati dallo sviluppo della tecnica chirurgica. Si stabilisce dunque un protocollo terapeutico dopo aver identificato la malformazione, stimato la gravità delle alterazioni tissutali e valutato la capacità di crescita dei territori interessati. E’ fondamentale, oltre che il rimodellamento della morfologia, il recupero delle funzioni ed il trattamento rieducativo. E’ quindi evidente che si tratta di una chirurgia di equipe che può portare risultati positivi solo se realizzata con fiducia reciproca tra i vari operatori.

  20. Arctic lineage-canine distemper virus as a cause of death in Apennine wolves (Canis lupus) in Italy.

    PubMed

    Di Sabatino, Daria; Lorusso, Alessio; Di Francesco, Cristina E; Gentile, Leonardo; Di Pirro, Vincenza; Bellacicco, Anna Lucia; Giovannini, Armando; Di Francesco, Gabriella; Marruchella, Giuseppe; Marsilio, Fulvio; Savini, Giovanni

    2014-01-01

    Canine distemper virus (CDV) infection is a primary threat affecting a wide number of carnivore species, including wild animals. In January 2013, two carcasses of Apennine wolves (Canis lupus) were collected in Ortona dei Marsi (L'Aquila province, Italy) by the local Veterinary Services. CDV was immediately identified either by RT-PCR or immunohistochemistry in lung and central nervous tissue samples. At the same time, severe clinical signs consistent with CDV infection were identified and taped (Videos S1-S3) from three wolves rescued in the areas surrounding the National Parks of the Abruzzi region by the Veterinary Services. The samples collected from these symptomatic animals also turned out CDV positive by RT-PCR. So far, 30 carcasses of wolves were screened and CDV was detected in 20 of them. The sequencing of the haemagglutinin gene and subsequent phylogenetic analysis demonstrated that the identified virus belonged to the CDV Arctic lineage. Strains belonging to this lineage are known to circulate in Italy and in Eastern Europe amongst domestic dogs. To the best of our knowledge this is the first report of CDV Arctic lineage epidemics in the wild population in Europe.