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Sample records for microfluidic chaotic bubble

  1. Bubbles and foams in microfluidics.

    PubMed

    Huerre, Axel; Miralles, Vincent; Jullien, Marie-Caroline

    2014-09-28

    Microfluidics offers great tools to produce highly-controlled dispersions of gas into liquid, from isolated bubbles to organized microfoams. Potential technological applications are manifold, from novel materials to scaffolds for tissue engineering or enhanced oil recovery. More fundamentally, microfluidics makes it possible to investigate the physics of complex systems such as foams at scales where the capillary forces become dominant, in model experiments involving few well-controlled parameters. In this context, this review does not have the ambition to detail in a comprehensive manner all the techniques and applications involving bubbles and foams in microfluidics. Rather, it focuses on particular consequences of working at the microscale, under confinement, and hopes to provide insight into the physics of such systems. The first part of this work focuses on bubbles, and more precisely on (i) bubble generation, where the confinement can suppress capillary instabilities while inertial effects may play a role, and (ii) bubble dynamics, paying special attention to the lubrication film between bubble and wall and the influence of confinement. The second part addresses the formation and dynamics of microfoams, emphasizing structural differences from macroscopic foams and the influence of the confinement.

  2. Microfluidic actuation using electrochemically generated bubbles.

    PubMed

    Hua, Susan Z; Sachs, Frederick; Yang, David X; Chopra, Harsh Deep

    2002-12-15

    Bubble-based actuation in microfluidic applications is attractive owing to elementary microfabrication requirements. In the present study, the mechanical and chemical characteristics of electrochemically generated bubble valves were studied. By generating electrochemical bubbles as valves directly inside the channel, valves could be closed and opened in milliseconds. Whereas bubble inflation (or valve closing) rate increases with applied voltage, small microfluidic dimensions accelerate bubble deflation rates. It is found that bubbles need not collapse fully to restore full flow, and the channel opens when its hydraulic resistance equals that between the bubble and the wall--a process requiring only milliseconds. Since only picomoles of salt are needed to generate bubbles, pH gradients that are invariably associated with electrochemical reactions were readily suppressed by using a small amount of buffer, as visualized by a pH-sensitive fluorescent dye. A range of common laboratory reagents and electrolytes in varying concentrations, including weak to strong acids and bases, as well as nonaqueous/aqueous mixtures were successfully tested. Using such bubble valves, an eight-way multiplexer was fabricated and tested. PMID:12510764

  3. Intensely oscillating cavitation bubble in microfluidics

    NASA Astrophysics Data System (ADS)

    Siew-Wan, Ohl; Tandiono; Klaseboer, Evert; Dave, Ow; Choo, Andre; Claus-Dieter, Ohl

    2015-12-01

    This study reports the technical breakthrough in generating intense ultrasonic cavitation in the confinement of a microfluidics channel [1], and applications that has been developed on this platform for the past few years [2,3,4,5]. Our system consists of circular disc transducers (10-20 mm in diameter), the microfluidics channels on PDMS (polydimethylsiloxane), and a driving circuitry. The cavitation bubbles are created at the gas- water interface due to strong capillary waves which are generated when the system is driven at its natural frequency (around 100 kHz) [1]. These bubbles oscillate and collapse within the channel. The bubbles are useful for sonochemistry and the generation of sonoluminescence [2]. When we add bacteria (Escherichia coli), and yeast cells (Pichia pastoris) into the microfluidics channels, the oscillating and collapsing bubbles stretch and lyse these cells [3]. Furthermore, the system is effective (DNA of the harvested intracellular content remains largely intact), and efficient (yield reaches saturation in less than 1 second). In another application, human red blood cells are added to a microchamber. Cell stretching and rapture are observed when a laser generated cavitation bubble expands and collapses next to the cell [4]. A numerical model of a liquid pocket surrounded by a membrane with surface tension which was placed next to an oscillating bubble was developed using the Boundary Element Method. The simulation results showed that the stretching of the liquid pocket occurs only when the surface tension is within a certain range.

  4. Droplets and Bubbles in Microfluidic Devices

    NASA Astrophysics Data System (ADS)

    Anna, Shelley Lynn

    2016-01-01

    Precise, tunable emulsions and foams produced in microfluidic geometries have found wide application in biochemical analysis and materials synthesis and characterization. Superb control of the volume, uniformity, and generation rate of droplets and bubbles arises from unique features of the microscale behavior of fluid interfaces. Fluid interfaces confined within microfluidic channels behave quite differently than their counterparts in unbounded flows. Confinement inhibits capillary instabilities so that breakup occurs by largely quasi-static mechanisms. The three-dimensional flow near confined interfaces in rectangular geometries and feedback effects from resistance changes in the entire microfluidic network play important roles in regulating the interfacial deformation. Timescales for transport of surfactants and particles to interfaces compete with flow timescales at the microscale, providing further opportunity for tuning the interfacial coverage and properties of individual droplets and bubbles.

  5. An active bubble trap and debubbler for microfluidic systems.

    PubMed

    Skelley, Alison M; Voldman, Joel

    2008-10-01

    We present a novel, fully integrated microfluidic bubble trap and debubbler. The 2-layer structure, based on a PDMS valve design, utilizes a featured membrane to stop bubble progression through the device. A pneumatic chamber directly above the trap is evacuated, and the bubble is pulled out through the gas-permeable PDMS membrane. Normal device operation, including continuous flow at atmospheric pressure, is maintained during the entire trapping and debubbling process. We present a range of trap sizes, from 2 to 10 mm diameter, and can trap and remove bubbles up to 25 microL in under 3 h.

  6. Laser-induced thermal bubbles for microfluidic applications.

    PubMed

    Zhang, Kai; Jian, Aoqun; Zhang, Xuming; Wang, Yu; Li, Zhaohui; Tam, Hwa-Yaw

    2011-04-01

    We present a unique bubble generation technique in microfluidic chips using continuous-wave laser-induced heat and demonstrate its application by creating micro-valves and micro-pumps. In this work, efficient generation of thermal bubbles of controllable sizes has been achieved using different geometries of chromium pads immersed in various types of fluid. Effective blocking of microfluidic channels (cross-section 500 × 40 μm(2)) and direct pumping of fluid at a flow rate of 7.2-28.8 μl h(-1) with selectable direction have also been demonstrated. A particular advantage of this technique is that it allows the generation of bubbles at almost any location in the microchannel and thus enables microfluidic control at any point of interest. It can be readily integrated into lab-on-a-chip systems to improve functionality.

  7. Bubble-induced acoustic mixing in a microfluidic device

    NASA Astrophysics Data System (ADS)

    Chen, Huaying; Petkovic-Duran, Karolina; Best, Michael; Zhu, Yonggang

    2015-12-01

    Homogeneous and fast mixing of samples at microscale is a critical requirement for successful applications of microfluidics in biochemical analysis, chemical synthesis, drug delivery and nanomaterial synthesis. This paper reports the optimisation of bubble-induced mixing in a microfluidic device in terms of voltage, driving frequency, piezo transducer position and PDMS thickness. The microfluidic device consists of a microwell (with the diameter of 1mm and volume of ~95 nL) with two rectangular bubble traps (400×400μm) on both sides of the well. After the injection of liquid, air bubbles were spontaneously trapped in two rectangular traps. When the frequency of a piezo was equal to the resonance frequency of air bubbles, strong liquid recirculation formed (so called acoustic microstreaming) in the vicinity of the interface of air bubbles and water. The acoustic induced flow of microbeads and mixing of water and fluorescence dye were imaged to study the mixing efficiency. For a given voltage and PDMS thickness, when the piezo was placed on top of the well, the mixing was most vigorous. For a given frequency, the mixing efficiency was directly proportional to the voltage (4-20V) and inversely proportional to the PDMS thickness (0.3-2mm). When the frequency driving the piezo was approaching the resonance frequency of air bubbles, the mixing efficiency was maximal, while when it was far away from the resonance frequency of air bubbles, the mixing efficiency was much lower. This work provides guidance to the design and the application of bubble-induced acoustic mixing in microfluidics.

  8. Slopes To Prevent Trapping of Bubbles in Microfluidic Channels

    NASA Technical Reports Server (NTRS)

    Greer, Harold E.; Lee, Michael C.; Smith, J. Anthony; Willis, Peter A.

    2010-01-01

    The idea of designing a microfluidic channel to slope upward along the direction of flow of the liquid in the channel has been conceived to help prevent trapping of gas bubbles in the channel. In the original application that gave rise to this idea, the microfluidic channels are parts of micro-capillary electrophoresis (microCE) devices undergoing development for use on Mars in detecting compounds indicative of life. It is necessary to prevent trapping of gas bubbles in these devices because uninterrupted liquid pathways are essential for sustaining the electrical conduction and flows that are essential for CE. The idea is also applicable to microfluidic devices that may be developed for similar terrestrial microCE biotechnological applications or other terrestrial applications in which trapping of bubbles in microfluidic channels cannot be tolerated. A typical microCE device in the original application includes, among other things, multiple layers of borosilicate float glass wafers. Microfluidic channels are formed in the wafers, typically by use of wet chemical etching. The figure presents a simplified cross section of part of such a device in which the CE channel is formed in the lowermost wafer (denoted the channel wafer) and, according to the present innovation, slopes upward into a via hole in another wafer (denoted the manifold wafer) lying immediately above the channel wafer. Another feature of the present innovation is that the via hole in the manifold wafer is made to taper to a wider opening at the top to further reduce the tendency to trap bubbles. At the time of reporting the information for this article, an effort to identify an optimum technique for forming the slope and the taper was in progress. Of the techniques considered thus far, the one considered to be most promising is precision milling by use of femtosecond laser pulses. Other similar techniques that may work equally well are precision milling using a focused ion beam, or a small diamond

  9. Bubble production mechanism in a microfluidic foam generator.

    PubMed

    Stoffel, M; Wahl, S; Lorenceau, E; Höhler, R; Mercier, B; Angelescu, D E

    2012-05-11

    We present the design and characterization of a microfluidic bubble generator that has the potential of producing monodisperse bubbles in 256 production channels that can operate in parallel. For a single production channel we demonstrate a production rate of up to 4 kHz with a coefficient of variation of less than 1%. We observe a two-stage bubble production mechanism: initially the gas spreads onto a shallow terrace, and then overflows into a larger foam collection channel; pinning of the liquid-gas meniscus is observed at the terrace edge, the result being an asymmetric pinch-off. A semiempirical physical model predicts the scaling of bubble size with fluid viscosity and gas pressure from measurements of the pinned meniscus width.

  10. Controlling the trajectories of bubble trains at a microfluidic junction

    NASA Astrophysics Data System (ADS)

    Parthiban, Pravien; Khan, Saif

    2011-11-01

    The increasing number of applications facilitated by digital microfluidic flows has resulted in a sustained interest in not only understanding the diverse, interesting and often complex dynamics associated with such flows in microchannel networks but also in developing facile strategies to control them. We find that there are readily accessible flow speeds wherein resistance to flow in microchannels decreases with an increase in the number of confined bubbles present, and exploit this intriguing phenomenon to sort all bubble of a train exclusively into one of the arms of a nominally symmetric microfluidic loop. We also demonstrate how the arm into which the train filters into can be chosen by applying a temporary external stimulus by means of an additional flow of the continuous liquid into one the arms of the loop. Furthermore, we show how by tuning the magnitude and period of this temporary stimulus we can switch controllably, the traffic of bubbles between both arms of the loop even when the loop is asymmetric. The results of this work should aid in developing viable methods to regulate traffic of digital flows in microfluidic networks.

  11. Nonlinear dynamics of drops and bubbles and chaotic phenomena

    NASA Technical Reports Server (NTRS)

    Trinh, Eugene H.; Leal, L. G.; Feng, Z. C.; Holt, R. G.

    1994-01-01

    Nonlinear phenomena associated with the dynamics of free drops and bubbles are investigated analytically, numerically and experimentally. Although newly developed levitation and measurement techniques have been implemented, the full experimental validation of theoretical predictions has been hindered by interfering artifacts associated with levitation in the Earth gravitational field. The low gravity environment of orbital space flight has been shown to provide a more quiescent environment which can be utilized to better match the idealized theoretical conditions. The research effort described in this paper is a closely coupled collaboration between predictive and guiding theoretical activities and a unique experimental program involving the ultrasonic and electrostatic levitation of single droplets and bubbles. The goal is to develop and to validate methods based on nonlinear dynamics for the understanding of the large amplitude oscillatory response of single drops and bubbles to both isotropic and asymmetric pressure stimuli. The first specific area on interest has been the resonant coupling between volume and shape oscillatory modes isolated gas or vapor bubbles in a liquid host. The result of multiple time-scale asymptotic treatment, combined with domain perturbation and bifurcation methods, has been the prediction of resonant and near-resonant coupling between volume and shape modes leading to stable as well as chaotic oscillations. Experimental investigations of the large amplitude shape oscillation modes of centimeter-size single bubbles trapped in water at 1 G and under reduced hydrostatic pressure, have suggested the possibility of a low gravity experiment to study the direct coupling between these low frequency shape modes and the volume pulsation, sound-radiating mode. The second subject of interest has involved numerical modeling, using the boundary integral method, of the large amplitude shape oscillations of charged and uncharged drops in the presence

  12. Rigorous buoyancy driven bubble mixing for centrifugal microfluidics.

    PubMed

    Burger, S; Schulz, M; von Stetten, F; Zengerle, R; Paust, N

    2016-01-21

    We present batch-mode mixing for centrifugal microfluidics operated at fixed rotational frequency. Gas is generated by the disk integrated decomposition of hydrogen peroxide (H2O2) to liquid water (H2O) and gaseous oxygen (O2) and inserted into a mixing chamber. There, bubbles are formed that ascent through the liquid in the artificial gravity field and lead to drag flow. Additionaly, strong buoyancy causes deformation and rupture of the gas bubbles and induces strong mixing flows in the liquids. Buoyancy driven bubble mixing is quantitatively compared to shake mode mixing, mixing by reciprocation and vortex mixing. To determine mixing efficiencies in a meaningful way, the different mixers are employed for mixing of a lysis reagent and human whole blood. Subsequently, DNA is extracted from the lysate and the amount of DNA recovered is taken as a measure for mixing efficiency. Relative to standard vortex mixing, DNA extraction based on buoyancy driven bubble mixing resulted in yields of 92 ± 8% (100 s mixing time) and 100 ± 8% (600 s) at 130g centrifugal acceleration. Shake mode mixing yields 96 ± 11% and is thus equal to buoyancy driven bubble mixing. An advantage of buoyancy driven bubble mixing is that it can be operated at fixed rotational frequency, however. The additional costs of implementing buoyancy driven bubble mixing are low since both the activation liquid and the catalyst are very low cost and no external means are required in the processing device. Furthermore, buoyancy driven bubble mixing can easily be integrated in a monolithic manner and is compatible to scalable manufacturing technologies such as injection moulding or thermoforming. We consider buoyancy driven bubble mixing an excellent alternative to shake mode mixing, in particular if the processing device is not capable of providing fast changes of rotational frequency or if the low average rotational frequency is challenging for the other integrated fluidic operations. PMID:26607320

  13. Rigorous buoyancy driven bubble mixing for centrifugal microfluidics.

    PubMed

    Burger, S; Schulz, M; von Stetten, F; Zengerle, R; Paust, N

    2016-01-21

    We present batch-mode mixing for centrifugal microfluidics operated at fixed rotational frequency. Gas is generated by the disk integrated decomposition of hydrogen peroxide (H2O2) to liquid water (H2O) and gaseous oxygen (O2) and inserted into a mixing chamber. There, bubbles are formed that ascent through the liquid in the artificial gravity field and lead to drag flow. Additionaly, strong buoyancy causes deformation and rupture of the gas bubbles and induces strong mixing flows in the liquids. Buoyancy driven bubble mixing is quantitatively compared to shake mode mixing, mixing by reciprocation and vortex mixing. To determine mixing efficiencies in a meaningful way, the different mixers are employed for mixing of a lysis reagent and human whole blood. Subsequently, DNA is extracted from the lysate and the amount of DNA recovered is taken as a measure for mixing efficiency. Relative to standard vortex mixing, DNA extraction based on buoyancy driven bubble mixing resulted in yields of 92 ± 8% (100 s mixing time) and 100 ± 8% (600 s) at 130g centrifugal acceleration. Shake mode mixing yields 96 ± 11% and is thus equal to buoyancy driven bubble mixing. An advantage of buoyancy driven bubble mixing is that it can be operated at fixed rotational frequency, however. The additional costs of implementing buoyancy driven bubble mixing are low since both the activation liquid and the catalyst are very low cost and no external means are required in the processing device. Furthermore, buoyancy driven bubble mixing can easily be integrated in a monolithic manner and is compatible to scalable manufacturing technologies such as injection moulding or thermoforming. We consider buoyancy driven bubble mixing an excellent alternative to shake mode mixing, in particular if the processing device is not capable of providing fast changes of rotational frequency or if the low average rotational frequency is challenging for the other integrated fluidic operations.

  14. Hydrophilic strips for preventing air bubble formation in a microfluidic chamber.

    PubMed

    Choi, Munseok; Na, Yang; Kim, Sung-Jin

    2015-12-01

    In a microfluidic chamber, unwanted formation of air bubbles is a critical problem. Here, we present a hydrophilic strip array that prevents air bubble formation in a microfluidic chamber. The array is located on the top surface of the chamber, which has a large variation in width, and consists of a repeated arrangement of super- and moderately hydrophilic strips. This repeated arrangement allows a flat meniscus (i.e. liquid front) to form when various solutions consisting of a single stream or two parallel streams with different hydrophilicities move through the chamber. The flat meniscus produced by the array completely prevents the formation of bubbles. Without the array in the chamber, the meniscus shape is highly convex, and bubbles frequently form in the chamber. This hydrophilic strip array will facilitate the use of a microfluidic chamber with a large variation in width for various microfluidic applications. PMID:26382942

  15. Hydrophilic strips for preventing air bubble formation in a microfluidic chamber.

    PubMed

    Choi, Munseok; Na, Yang; Kim, Sung-Jin

    2015-12-01

    In a microfluidic chamber, unwanted formation of air bubbles is a critical problem. Here, we present a hydrophilic strip array that prevents air bubble formation in a microfluidic chamber. The array is located on the top surface of the chamber, which has a large variation in width, and consists of a repeated arrangement of super- and moderately hydrophilic strips. This repeated arrangement allows a flat meniscus (i.e. liquid front) to form when various solutions consisting of a single stream or two parallel streams with different hydrophilicities move through the chamber. The flat meniscus produced by the array completely prevents the formation of bubbles. Without the array in the chamber, the meniscus shape is highly convex, and bubbles frequently form in the chamber. This hydrophilic strip array will facilitate the use of a microfluidic chamber with a large variation in width for various microfluidic applications.

  16. Origin of periodic and chaotic dynamics due to drops moving in a microfluidic loop device.

    PubMed

    Maddala, Jeevan; Vanapalli, Siva A; Rengaswamy, Raghunathan

    2014-02-01

    Droplets moving in a microfluidic loop device exhibit both periodic and chaotic behaviors based on the inlet droplet spacing. We observe that the periodic behavior is an outcome of carrier phase mass conservation principle, which translates into a droplet spacing quantization rule. This rule implies that the summation of exit spacing is equal to an integral multiple of inlet spacing. This principle also enables identification of periodicity in experimental systems with input scatter. We find that the origin of chaotic behavior is through intermittency, which arises when drops enter and leave the junctions at the same time. We derive an analytical expression to estimate the occurrence of these chaotic regions as a function of system parameters. We provide experimental, simulation, and analytical results to validate the origin of periodic and chaotic behavior.

  17. Sonoporation of suspension cells with a single cavitation bubble in a microfluidic confinement.

    PubMed

    Gac, Séverine Le; Zwaan, Ed; van den Berg, Albert; Ohl, Claus-Dieter

    2007-12-01

    We report here the sonoporation of HL60 (human promyelocytic leukemia) suspension cells in a microfluidic confinement using a single laser-induced cavitation bubble. Cavitation bubbles can induce membrane poration of cells located in their close vicinity. Membrane integrity of suspension cells placed in a microfluidic chamber is probed through either the calcein release out of calcein-loaded cells or the uptake of trypan blue. Cells that are located farther away than four times Rmax (maximum bubble radius) from the cavitation bubble center remain fully unaffected, while cells closer than 0.75 Rmax become porated with a probability of >75%. These results enable us to define a distance of 0.75 Rmax as a critical interaction distance of the cavitation bubble with HL60 suspension cells. These experiments suggest that flow-induced poration of suspension cells is applicable in lab-on-a-chip systems, and this might be an interesting alternative to electroporation.

  18. Unscrambling the Omlette: a New Bubble and Crystal Clustering Mechanism in Chaotically Mixed Magma Flows

    NASA Astrophysics Data System (ADS)

    Robertson, J.; Metcalfe, G.; Wang, S.; Barnes, S. J.

    2014-12-01

    The concentration of bubbles, crystals or droplets into small volumes of magma is a key trigger for many interesting magmatic processes. For example, gas slugs driving Strombolian eruptions form from the coalesence of exsolved bubbles within a volcanic conduit, while Ni-Cu-PGE magmatic sulfide deposits require a concentration of dense sulfide droplets from a large volume of magma to form a massive ore body. However the physical mechanism for this clustering remains unresolved - especially since small particles in active magma flows are expected to mostly track flow streamlines rather than clustering. We have uncovered a previously unreported clustering mechanism which is applicable to magmatic flows. This mechanism involves the interaction of particles with two kinds of chaotic flow structure: (a) high-strain regions within the well-mixed chaotic zones of the flow, and (b) unmixed islands of stability within the chaotic flow, known as Kolmogorov-Arnold-Moser (KAM) regions. The first figure shows the difference between chaotic and KAM regions in a chaotic laminar pipe flow. Trapping occurs when particles are scattered from high-strain regions in the chaotic zones and become trapped in the KAM regions, leading to a rapid concentration of particles relative to their original distribution (shown in the second series of figures). Using a combination of these analogue experiments and theoretical analysis we outline the conditions under which this clustering process can occur. We examine the onset of secondary density-related instabilities and the effects of increased particle-particle interaction within the clustered particles, and highlight the impact of particle clustering on the dynamics of magma ascent and emplacement.

  19. Bubble-free and pulse-free fluid delivery into microfluidic devices.

    PubMed

    Kang, Yang Jun; Yeom, Eunseop; Seo, Eunseok; Lee, Sang-Joon

    2014-01-01

    The bubble-free and pulse-free fluid delivery is critical to reliable operation of microfluidic devices. In this study, we propose a new method for stable bubble-free and pulse-free fluid delivery in a microfluidic device. Gas bubbles are separated from liquid by using the density difference between liquid and gas in a closed cavity. The pulsatile flow caused by a peristaltic pump is stabilized via gas compressibility. To demonstrate the proposed method, a fluidic chamber which is composed of two needles for inlet and outlet, one needle for a pinch valve and a closed cavity is carefully designed. By manipulating the opening or closing of the pinch valve, fluids fill up the fluidic chamber or are delivered into a microfluidic device through the fluidic chamber in a bubble-free and pulse-free manner. The performance of the proposed method in bubble-free and pulse-free fluid delivery is quantitatively evaluated. The proposed method is then applied to monitor the temporal variations of fluidic flows of rat blood circulating within a complex fluidic network including a rat, a pinch valve, a reservoir, a peristaltic pump, and the microfluidic device. In addition, the deformability of red blood cells and platelet aggregation are quantitatively evaluated from the information on the temporal variations of blood flows in the microfluidic device. These experimental demonstrations confirm that the proposed method is a promising tool for stable, bubble-free, and pulse-free supply of fluids, including whole blood, into a microfluidic device. Furthermore, the proposed method will be used to quantify the biophysical properties of blood circulating within an extracorporeal bypass loop of animal models. PMID:24753723

  20. Bubble-free and pulse-free fluid delivery into microfluidic devices.

    PubMed

    Kang, Yang Jun; Yeom, Eunseop; Seo, Eunseok; Lee, Sang-Joon

    2014-01-01

    The bubble-free and pulse-free fluid delivery is critical to reliable operation of microfluidic devices. In this study, we propose a new method for stable bubble-free and pulse-free fluid delivery in a microfluidic device. Gas bubbles are separated from liquid by using the density difference between liquid and gas in a closed cavity. The pulsatile flow caused by a peristaltic pump is stabilized via gas compressibility. To demonstrate the proposed method, a fluidic chamber which is composed of two needles for inlet and outlet, one needle for a pinch valve and a closed cavity is carefully designed. By manipulating the opening or closing of the pinch valve, fluids fill up the fluidic chamber or are delivered into a microfluidic device through the fluidic chamber in a bubble-free and pulse-free manner. The performance of the proposed method in bubble-free and pulse-free fluid delivery is quantitatively evaluated. The proposed method is then applied to monitor the temporal variations of fluidic flows of rat blood circulating within a complex fluidic network including a rat, a pinch valve, a reservoir, a peristaltic pump, and the microfluidic device. In addition, the deformability of red blood cells and platelet aggregation are quantitatively evaluated from the information on the temporal variations of blood flows in the microfluidic device. These experimental demonstrations confirm that the proposed method is a promising tool for stable, bubble-free, and pulse-free supply of fluids, including whole blood, into a microfluidic device. Furthermore, the proposed method will be used to quantify the biophysical properties of blood circulating within an extracorporeal bypass loop of animal models.

  1. Bubble production using a Non-Newtonian fluid in microfluidic flow focusing device

    NASA Astrophysics Data System (ADS)

    Wang, Yi-Lin; Ward, Thomas; Grant, Christine

    2012-02-01

    We experimentally study the production of micrometer-sized bubbles using microfluidic technology and a flow-focusing geometry. Bubbles are produced by using a mixture containing aqueous polyacrylamide of concentrations ranging from 0.01-0.10% by weight and several solution also containing a sodium-lauryl-sulfate (SLS) surfactant at concentrations ranging 0.01-0.1% by weight. The fluids are driven by controlling the static pressure above a hydrostatic head of the liquid while the disperse phase fluid static pressure is held constant (air). In the absence of surfactant the bubble production is discontinuous. The addition of surfactant stabilizes the bubble production. In each type of experiment, the bubble length l, velocity U and production frequency φ are measured and compared as a function of the inlet pressure ratio. The bubbles exhibit a contraction in their downstream length as a function of the polymer concentration which is investigated.

  2. Bubble adhesion in a microfluidic model of cardiovascular microbubble sticking

    NASA Astrophysics Data System (ADS)

    Stephen, James

    2005-11-01

    Motivated by a developmental gas embolotherapy that uses selectively formed gas bubbles for therapy, we investigated bubble sticking in two geometries: planar surfaces and circular cross-section microchannels. It was hypothesized that both surface tension and adhesion forces between the vessel wall and adsorbed molecules on the bubble surface are responsible for bubble sticking in microvessels. The planar geometry experiments demonstrated the effect of serum albumin concentration on surface tension, the tendency for bubbles to resist adhesion to an endothelial cell monolayer, and the apparent role of geometry in bubble adhesion. Microchannels (140 to 800μm in diameter) were constructed from polydimethylsiloxane (PDMS), and bubbles of various volumes were introduced into the fluid-filled channel to occlude the channel's full diameter. Once the bubble was lodged within the channel, the pressures at the inlet and outlet were slowly adjusted, and bubble motion, including the contact angle, was recorded using a microscope and CCD camera. The effects of bubble volume, microchannel diameter, serum albumin concentration, and endothelialized vs. non-endothelialized channel walls were investigated. Noting that surface tension force scales with contact line length and molecular adhesion force scales with contact area, we examined the relative contributions of the two sticking mechanisms. This work is supported by NIH grant EB003541 and Whitaker Foundation grant RG-03-0017.

  3. Post-Formation Shrinkage and Stabilization of Microfluidic Bubbles in Lipid Solution.

    PubMed

    Shih, Roger; Lee, Abraham P

    2016-03-01

    Medical ultrasound imaging often employs ultrasound contrast agents (UCAs), injectable microbubbles stabilized by shells or membranes. In tissue, the compressible gas cores can strongly scatter acoustic signals, resonate, and emit harmonics. However, bubbles generated by conventional methods have nonuniform sizes, reducing the fraction that resonates with a given transducer. Microfluidic flow-focusing is an alternative production method which generates highly monodisperse bubbles with uniform constituents, enabling more-efficient contrast enhancement than current UCAs. Production size is tunable by adjusting gas pressure and solution flow rate, but solution effects on downstream stable size and lifetime have not been closely examined. This study therefore investigated several solution parameters, including the DSPC/DSPE-PEG2000 lipid ratio, concentration, viscosity, and preparation temperature to determine their effects on stabilization. It was found that bubble lifetime roughly correlated with stable size, which in turn was strongly influenced by primary-lipid-to-emulsifier ratio, analogous to its effects on conventional bubble yield and Langmuir-trough compressibility in existing studies. Raising DSPE-PEG2000 fraction in solution reduced bubble surface area in proportion to its reduction of lipid packing density at low compression in literature. In addition, the surface area was found to increase proportionately with lipid concentration above 2.1 mM. However, viscosities above or below 2.3-3.3 mPa·s seemed to reduce bubble size. Finally, lipid preparation at room temperature led to smaller bubbles compared to preparation near or above the primary lipid's phase transition point. Understanding these effects will further improve on postformation control over microfluidic bubble production, and facilitate size-tuning for optimal contrast enhancement. PMID:26820229

  4. Experimental test of scaling of mixing by chaotic advection in droplets moving through microfluidic channels.

    PubMed

    Song, Helen; Bringer, Michelle R; Tice, Joshua D; Gerdts, Cory J; Ismagilov, Rustem F

    2003-12-01

    This letter describes an experimental test of a simple argument that predicts the scaling of chaotic mixing in a droplet moving through a winding microfluidic channel. Previously, scaling arguments for chaotic mixing have been described for a flow that reduces striation length by stretching, folding, and reorienting the fluid in a manner similar to that of the baker's transformation. The experimentally observed flow patterns within droplets (or plugs) resembled the baker's transformation. Therefore, the ideas described in the literature could be applied to mixing in droplets to obtain the scaling argument for the dependence of the mixing time, t~(aw/U)log(Pe), where w [m] is the cross-sectional dimension of the microchannel, a is the dimensionless length of the plug measured relative to w, U [m s(-1)] is the flow velocity, Pe is the Péclet number (Pe=wU/D), and D [m(2)s(-1)] is the diffusion coefficient of the reagent being mixed. Experiments were performed to confirm the scaling argument by varying the parameters w, U, and D. Under favorable conditions, submillisecond mixing has been demonstrated in this system.

  5. Effect of surface waves on the secondary Bjerknes force experienced by bubbles in a microfluidic channel.

    PubMed

    Doinikov, Alexander A; Combriat, Thomas; Thibault, Pierre; Marmottant, Philippe

    2016-08-01

    An analytical expression is derived for the secondary Bjerknes force experienced by two cylindrical bubbles in a microfluidic channel with planar elastic walls. The derived expression takes into account that the bubbles generate two types of scattered acoustic waves: bulk waves that propagate in the fluid gap with the speed of sound and Lamb-type surface waves that propagate at the fluid-wall interfaces with a much lower speed than that of the bulk waves. It is shown that the surface waves cause the bubbles to form a bound pair in which the equilibrium interbubble distance is determined by the wavelength of the surface waves, which is much smaller than the acoustic wavelength. Comparison of theoretical and experimental results demonstrates good agreement.

  6. Effect of surface waves on the secondary Bjerknes force experienced by bubbles in a microfluidic channel.

    PubMed

    Doinikov, Alexander A; Combriat, Thomas; Thibault, Pierre; Marmottant, Philippe

    2016-08-01

    An analytical expression is derived for the secondary Bjerknes force experienced by two cylindrical bubbles in a microfluidic channel with planar elastic walls. The derived expression takes into account that the bubbles generate two types of scattered acoustic waves: bulk waves that propagate in the fluid gap with the speed of sound and Lamb-type surface waves that propagate at the fluid-wall interfaces with a much lower speed than that of the bulk waves. It is shown that the surface waves cause the bubbles to form a bound pair in which the equilibrium interbubble distance is determined by the wavelength of the surface waves, which is much smaller than the acoustic wavelength. Comparison of theoretical and experimental results demonstrates good agreement. PMID:27627390

  7. Effect of surface waves on the secondary Bjerknes force experienced by bubbles in a microfluidic channel

    NASA Astrophysics Data System (ADS)

    Doinikov, Alexander A.; Combriat, Thomas; Thibault, Pierre; Marmottant, Philippe

    2016-08-01

    An analytical expression is derived for the secondary Bjerknes force experienced by two cylindrical bubbles in a microfluidic channel with planar elastic walls. The derived expression takes into account that the bubbles generate two types of scattered acoustic waves: bulk waves that propagate in the fluid gap with the speed of sound and Lamb-type surface waves that propagate at the fluid-wall interfaces with a much lower speed than that of the bulk waves. It is shown that the surface waves cause the bubbles to form a bound pair in which the equilibrium interbubble distance is determined by the wavelength of the surface waves, which is much smaller than the acoustic wavelength. Comparison of theoretical and experimental results demonstrates good agreement.

  8. Effects of coupling, bubble size, and spatial arrangement on chaotic dynamics of microbubble cluster in ultrasonic fields.

    PubMed

    Dzaharudin, Fatimah; Suslov, Sergey A; Manasseh, Richard; Ooi, Andrew

    2013-11-01

    Microbubble clustering may occur when bubbles become bound to targeted surfaces or are grouped by acoustic radiation forces in medical diagnostic applications. The ability to identify the formation of such clusters from the ultrasound echoes may be of practical use. Nonlinear numerical simulations were performed on clusters of microbubbles modeled by the modified Keller-Miksis equations. Encapsulated bubbles were considered to mimic practical applications but the aim of the study was to examine the effects of inter-bubble spacing and bubble size on the dynamical behavior of the cluster and to see if chaotic or bifurcation characteristics could be helpful in diagnostics. It was found that as microbubbles were clustered closer together, their oscillation amplitude for a given applied ultrasound power was reduced, and for inter-bubble spacing smaller than about ten bubble radii nonlinear subharmonics and ultraharmonics were eliminated. For clustered microbubbles, as for isolated microbubbles, an increase in the applied acoustic power caused bifurcations and transition to chaos. The bifurcations preceding chaotic behavior were identified by Floquet analysis and confirmed to be of the period-doubling type. It was found that as the number of microbubbles in a cluster increased, regularization occurred at lower ultrasound power and more windows of order appeared.

  9. Exploring bubble oscillation and mass transfer enhancement in acoustic-assisted liquid-liquid extraction with a microfluidic device

    PubMed Central

    Xie, Yuliang; Chindam, Chandraprakash; Nama, Nitesh; Yang, Shikuan; Lu, Mengqian; Zhao, Yanhui; Mai, John D.; Costanzo, Francesco; Huang, Tony Jun

    2015-01-01

    We investigated bubble oscillation and its induced enhancement of mass transfer in a liquid-liquid extraction process with an acoustically-driven, bubble-based microfluidic device. The oscillation of individually trapped bubbles, of known sizes, in microchannels was studied at both a fixed frequency, and over a range of frequencies. Resonant frequencies were analytically identified and were found to be in agreement with the experimental observations. The acoustic streaming induced by the bubble oscillation was identified as the cause of this enhanced extraction. Experiments extracting Rhodanmine B from an aqueous phase (DI water) to an organic phase (1-octanol) were performed to determine the relationship between extraction efficiency and applied acoustic power. The enhanced efficiency in mass transport via these acoustic-energy-assisted processes was confirmed by comparisons against a pure diffusion-based process. PMID:26223474

  10. A simple PDMS-based microfluidic channel design that removes bubbles for long-term on-chip culture of mammalian cells.

    PubMed

    Zheng, Wenfu; Wang, Zhuo; Zhang, Wei; Jiang, Xingyu

    2010-11-01

    This report shows methods to fabricate polydimethylsiloxane (PDMS) microfluidic systems for long-term (up to 10 day) cell culture. Undesired bubble accumulation in microfluidic channels abruptly changes the microenvironment of adherent cells and leads to the damage and death of cells. Existing bubble trapping approaches have drawbacks such as the need to pause fluid flow, requirement for external vacuum or pressure source, and possible cytotoxicity. This study reports two kinds of integrated bubble trap (IBT) which have excellent properties, including simplicity in structure, ease in fabrication, no interference with the flow, and long-term stability. IBT-A provides the simplest solution to prevent bubbles from entering microfluidic channels. In situ time-lapse imaging experiments indicate that IBT-B is an excellent device both for bubble trapping and debubbling in cell-loaded microfluidics. MC 3T3 E1 cells, cultured in a long and curved microfluidic channel equipped with IBT-B, showed high viability and active proliferation after 10 days of continuous fluid flow. The comprehensive measures taken in our experiments have led to successful long-term, bubble-free, on-chip culture of cells.

  11. Formation of droplets and bubbles in a microfluidic T-junction-scaling and mechanism of break-up.

    PubMed

    Garstecki, Piotr; Fuerstman, Michael J; Stone, Howard A; Whitesides, George M

    2006-03-01

    This article describes the process of formation of droplets and bubbles in microfluidic T-junction geometries. At low capillary numbers break-up is not dominated by shear stresses: experimental results support the assertion that the dominant contribution to the dynamics of break-up arises from the pressure drop across the emerging droplet or bubble. This pressure drop results from the high resistance to flow of the continuous (carrier) fluid in the thin films that separate the droplet from the walls of the microchannel when the droplet fills almost the entire cross-section of the channel. A simple scaling relation, based on this assertion, predicts the size of droplets and bubbles produced in the T-junctions over a range of rates of flow of the two immiscible phases, the viscosity of the continuous phase, the interfacial tension, and the geometrical dimensions of the device. PMID:16511628

  12. Bubbles

    NASA Astrophysics Data System (ADS)

    Prosperetti, Andrea

    2004-06-01

    Vanitas vanitatum et omnia vanitas: bubbles are emptiness, non-liquid, a tiny cloud shielding a mathematical singularity. Born from chance, a violent and brief life ending in the union with the (nearly) infinite. But a wealth of phenomena spring forth from this nothingness: underwater noise, sonoluminescence, boiling, and many others. Some recent results on a "blinking bubble" micropump and vapor bubbles in sound fields are outlined. The last section describes Leonardo da Vinci's observation of the non-rectlinear ascent of buoyant bubbles and justifies the name Leonardo's paradox recently attributed to this phenomenon.

  13. The effect of high viscosity on the collapse-like chaotic and regular periodic oscillations of a harmonically excited gas bubble.

    PubMed

    Hegedűs, Ferenc; Klapcsik, Kálmán

    2015-11-01

    In the last decade many industrial applications have emerged based on the rapidly developing ultrasonic technology such as ultrasonic pasteurization, alteration of the viscosity of food systems, and mixing immiscible liquids. The fundamental physical basis of these applications is the prevailing extreme conditions (high temperature, pressure and even shock waves) during the collapse of acoustically excited bubbles. By applying the sophisticated numerical techniques of modern bifurcation theory, the present study intends to reveal the regions in the excitation pressure amplitude-ambient temperature parameter plane where collapse-like motion of an acoustically driven gas bubble in highly viscous glycerine exists. We report evidence that below a threshold temperature the bubble model, the Keller-Miksis equation, becomes an overdamped oscillator suppressing collapse-like behaviour. In addition, we have found periodic windows interspersed with chaotic regions indicating the presence of transient chaos, which is important from application point of view if predictability is required. PMID:26186832

  14. The effect of high viscosity on the collapse-like chaotic and regular periodic oscillations of a harmonically excited gas bubble.

    PubMed

    Hegedűs, Ferenc; Klapcsik, Kálmán

    2015-11-01

    In the last decade many industrial applications have emerged based on the rapidly developing ultrasonic technology such as ultrasonic pasteurization, alteration of the viscosity of food systems, and mixing immiscible liquids. The fundamental physical basis of these applications is the prevailing extreme conditions (high temperature, pressure and even shock waves) during the collapse of acoustically excited bubbles. By applying the sophisticated numerical techniques of modern bifurcation theory, the present study intends to reveal the regions in the excitation pressure amplitude-ambient temperature parameter plane where collapse-like motion of an acoustically driven gas bubble in highly viscous glycerine exists. We report evidence that below a threshold temperature the bubble model, the Keller-Miksis equation, becomes an overdamped oscillator suppressing collapse-like behaviour. In addition, we have found periodic windows interspersed with chaotic regions indicating the presence of transient chaos, which is important from application point of view if predictability is required.

  15. Lattice Boltzmann simulations of bubble formation in a microfluidic T-junction.

    PubMed

    Amaya-Bower, Luz; Lee, Taehun

    2011-06-28

    A lattice Boltzmann equation method based on the Cahn-Hilliard diffuse interface theory is developed to investigate the bubble formation process in a microchannel with T-junction mixing geometry. The bubble formation process has different regimes, namely, squeezing, dripping and jetting regimes, which correspond to the primary forces acting on the system. Transition from regime to regime is generally dictated by the capillary number Ca, volumetric flow ratio Q and viscosity ratio λ. A systematic analysis is performed to evaluate these effects. The computations are performed in the range of 10(-4)

  16. Microfluidic Biochip Design

    NASA Technical Reports Server (NTRS)

    Panzarella, Charles

    2004-01-01

    As humans prepare for the exploration of our solar system, there is a growing need for miniaturized medical and environmental diagnostic devices for use on spacecrafts, especially during long-duration space missions where size and power requirements are critical. In recent years, the biochip (or Lab-on-a- Chip) has emerged as a technology that might be able to satisfy this need. In generic terms, a biochip is a miniaturized microfluidic device analogous to the electronic microchip that ushered in the digital age. It consists of tiny microfluidic channels, pumps and valves that transport small amounts of sample fluids to biosensors that can perform a variety of tests on those fluids in near real time. It has the obvious advantages of being small, lightweight, requiring less sample fluids and reagents and being more sensitive and efficient than larger devices currently in use. Some of the desired space-based applications would be to provide smaller, more robust devices for analyzing blood, saliva and urine and for testing water and food supplies for the presence of harmful contaminants and microorganisms. Our group has undertaken the goal of adapting as well as improving upon current biochip technology for use in long-duration microgravity environments. In addition to developing computational models of the microfluidic channels, valves and pumps that form the basis of every biochip, we are also trying to identify potential problems that could arise in reduced gravity and develop solutions to these problems. One such problem is due to the prevalence of bubbly sample fluids in microgravity. A bubble trapped in a microfluidic channel could be detrimental to the operation of a biochip. Therefore, the process of bubble formation in microgravity needs to be studied, and a model of this process has been developed and used to understand how bubbles develop and move through biochip components. It is clear that some type of bubble filter would be necessary in Space, and

  17. Chaotic cryptology

    NASA Astrophysics Data System (ADS)

    Martienssen, W.; Hübinger, B.; Doerner, R.

    A method to transfer secret information using chaotic dynamical systems is proposed. It is based on modulating a chaotic system with the message such that its time evolution contains the hidden information. Decryption of the cipher is achieved by chaos control. Operation of the scheme is demonstrated by en- and decoding a short german text.

  18. The Dynamics of Bubbles and Bubble Clouds.

    NASA Astrophysics Data System (ADS)

    Smereka, Peter Stenberg

    In an effort to understand acoustic cavitation noise the dynamics of periodically driven single bubbles and bubble clouds are examined. The single bubble equations are written as a perturbation of a Hamiltonian system and the conditions for resonances to occur are found, these can interact with the nonresonant orbit to produce jump and period-doubling bifurcations. To study the chaotic behavior a map which approximates the Poincare map in the resonant band is derived. The Poincare map is computed numerically which shows the formation of strange attractors which suddenly disappear leaving behind Smale horseshoe maps. The bubble cloud is studied using an averaged two-fluid model for bubbly flow with periodic driving at the boundary. The equations are examined both analytically and numerically. Local and global existence of solutions is proved and the existence of an absorbing set is established. An analysis of the linearized equations combined with estimates on the nonlinearity is used to prove the existence of nonlinear periodic orbit. This periodic orbit is a fixed point of the Poincare map and its stability is determined by finding the spectrum of the linearized Poincare map. This calculation combined with the absorbing set proves that the long term dynamics of the bubble cloud is finite dimensional. Numerical computations show the important attractors are a periodic -two orbit and a quasi-periodic orbit.

  19. Active liquid degassing in microfluidic systems.

    PubMed

    Karlsson, J Mikael; Gazin, Muriel; Laakso, Sanna; Haraldsson, Tommy; Malhotra-Kumar, Surbhi; Mäki, Minna; Goossens, Herman; van der Wijngaart, Wouter

    2013-11-21

    We present a method for efficient air bubble removal in microfluidic applications. Air bubbles are extracted from a liquid chamber into a vacuum chamber through a semipermeable membrane, consisting of PDMS coated with amorphous Teflon(®) AF 1600. Whereas air is efficiently extracted through the membrane, water loss is greatly reduced by the Teflon even at elevated temperatures. We present the water loss and permeability change with the amount of added Teflon AF to the membrane. Also, we demonstrate bubble-free, multiplex DNA amplification using PCR in a PDMS microfluidic device. PMID:24056885

  20. Foams for Microfluidics

    NASA Astrophysics Data System (ADS)

    Raven, Jan-Paul

    2005-11-01

    We present an experimental investigation of the assembly of microbubbles into a 2D foam and its flow in microchannels. Using a flow focusing method, we can produce a foam in situ on a microfluidic chip for a large range of liquid fractions. We study its flow dissipation along a channel, and the effect of constrictions. Microscopic imaging allows monitoring the transition from separated bubbles into the desired foam in which bubbles are closely packed. The foam flowrate depends non-linearly on the applied pressure, displaying a threshold pressure due to capillarity. The measurements are made in a channel with a height of 250 μm, resulting in bubbles whose height to diameter aspect ratio ranges between 0.3 and 1. We also produce an ultraflat foam (reducing the channel height to about 8 μm) with a bubble aspect ratio down to 0.02; we observe a marked change in bubble shape during the flow. The control of microfoam flows provides possible applications like transporting amphiphilic molecules on interfaces or the individual handling of gas pockets.

  1. Chaotic Terrain

    NASA Technical Reports Server (NTRS)

    2003-01-01

    [figure removed for brevity, see original site]

    Released 4 June 2003

    Chaotic terrain on Mars is thought to form when there is a sudden removal of subsurface water or ice, causing the surface material to slump and break into blocks. The chaotic terrain in this THEMIS visible image is confined to a crater just south of Elysium Planitia. It is common to see chaotic terrain in the vicinity of the catastrophic outflow channels on Mars, but the terrain in this image is on the opposite side of the planet from these channels, making it somewhat of an oddity.

    Image information: VIS instrument. Latitude -5.9, Longitude 108.1 East (251.9 West). 19 meter/pixel resolution.

    Note: this THEMIS visual image has not been radiometrically nor geometrically calibrated for this preliminary release. An empirical correction has been performed to remove instrumental effects. A linear shift has been applied in the cross-track and down-track direction to approximate spacecraft and planetary motion. Fully calibrated and geometrically projected images will be released through the Planetary Data System in accordance with Project policies at a later time.

    NASA's Jet Propulsion Laboratory manages the 2001 Mars Odyssey mission for NASA's Office of Space Science, Washington, D.C. The Thermal Emission Imaging System (THEMIS) was developed by Arizona State University, Tempe, in collaboration with Raytheon Santa Barbara Remote Sensing. The THEMIS investigation is led by Dr. Philip Christensen at Arizona State University. Lockheed Martin Astronautics, Denver, is the prime contractor for the Odyssey project, and developed and built the orbiter. Mission operations are conducted jointly from Lockheed Martin and from JPL, a division of the California Institute of Technology in Pasadena.

  2. Tuning bubbly structures in microchannels.

    PubMed

    Vuong, Sharon M; Anna, Shelley L

    2012-06-01

    Foams have many useful applications that arise from the structure and size distribution of the bubbles within them. Microfluidics allows for the rapid formation of uniform bubbles, where bubble size and volume fraction are functions of the input gas pressure, liquid flow rate, and device geometry. After formation, the microchannel confines the bubbles and determines the resulting foam structure. Bubbly structures can vary from a single row ("dripping"), to multiple rows ("alternating"), to densely packed bubbles ("bamboo" and dry foams). We show that each configuration arises in a distinct region of the operating space defined by bubble volume and volume fraction. We describe the boundaries between these regions using geometric arguments and show that the boundaries are functions of the channel aspect ratio. We compare these geometric arguments with foam structures observed in experiments using flow-focusing, T-junction, and co-flow designs to generate stable nitrogen bubbles in aqueous surfactant solution and stable droplets in oil containing dissolved surfactant. The outcome of this work is a set of design parameters that can be used to achieve desired foam structures as a function of device geometry and experimental control parameters.

  3. Suspended microfluidics.

    PubMed

    Casavant, Benjamin P; Berthier, Erwin; Theberge, Ashleigh B; Berthier, Jean; Montanez-Sauri, Sara I; Bischel, Lauren L; Brakke, Kenneth; Hedman, Curtis J; Bushman, Wade; Keller, Nancy P; Beebe, David J

    2013-06-18

    Although the field of microfluidics has made significant progress in bringing new tools to address biological questions, the accessibility and adoption of microfluidics within the life sciences are still limited. Open microfluidic systems have the potential to lower the barriers to adoption, but the absence of robust design rules has hindered their use. Here, we present an open microfluidic platform, suspended microfluidics, that uses surface tension to fill and maintain a fluid in microscale structures devoid of a ceiling and floor. We developed a simple and ubiquitous model predicting fluid flow in suspended microfluidic systems and show that it encompasses many known capillary phenomena. Suspended microfluidics was used to create arrays of collagen membranes, mico Dots (μDots), in a horizontal plane separating two fluidic chambers, demonstrating a transwell platform able to discern collective or individual cellular invasion. Further, we demonstrated that μDots can also be used as a simple multiplexed 3D cellular growth platform. Using the μDot array, we probed the combined effects of soluble factors and matrix components, finding that laminin mitigates the growth suppression properties of the matrix metalloproteinase inhibitor GM6001. Based on the same fluidic principles, we created a suspended microfluidic metabolite extraction platform using a multilayer biphasic system that leverages the accessibility of open microchannels to retrieve steroids and other metabolites readily from cell culture. Suspended microfluidics brings the high degree of fluidic control and unique functionality of closed microfluidics into the highly accessible and robust platform of open microfluidics.

  4. Chaotic Systems

    NASA Astrophysics Data System (ADS)

    Myasishchev, Denis; Bixler, David

    2009-04-01

    Chaos theory is a current topic in physics research and is of great scientific and applied interest. Chaotic systems include weather patterns, genetic evolution and free market economics. Modeling chaotic phenomena using electronic circuits is a convenient way to analyze nonlinear systems. We have built various types of circuits and examined the conditions under which chaos occurs. Chua's circuit and analog computing circuits (ones that directly model systems of differential equations) were in the spotlight during the fall semester. An R-C phase space diagram for the Chua's circuit was constructed and the phase transitions were examined. Different analog computing circuits were built and the resulting attractors, attractor phases, and bifurcations were recorded. A mechanical system, the two block train model, is the current focus of study. The goal is to examine attractors produced by a mechanical system, a computer simulation, and a corresponding circuit in order to prove that the same experimental results can be obtained from different sources. This way if a mechanical system is too complicated to build, it can be substituted by a suitable circuit.

  5. Microstreaming from Sessile Semicylindrical Bubbles

    NASA Astrophysics Data System (ADS)

    Hilgenfeldt, Sascha; Rallabandi, Bhargav; Guo, Lin; Wang, Cheng

    2014-03-01

    Powerful steady streaming flows result from the ultrasonic driving of microbubbles, in particular when these bubbles have semicylindrical cross section and are positioned in contact with a microfluidic channel wall. We have used this streaming in experiment to develop novel methods for trapping and sorting of microparticles by size, as well as for micromixing. Theoretically, we arrive at an analytical description of the streaming flow field through an asymptotic computation that, for the first time, reconciles the boundary layers around the bubble and along the substrate wall, and also takes into account the oscillation modes of the bubble. This approach gives insight into changes in the streaming pattern with bubble size and driving frequency, including a reversal of the flow direction at high frequencies with potentially useful applications. Present address: Mechanical and Aerospace Engineering, Missouri S &T.

  6. Microfluidic electronics.

    PubMed

    Cheng, Shi; Wu, Zhigang

    2012-08-21

    Microfluidics, a field that has been well-established for several decades, has seen extensive applications in the areas of biology, chemistry, and medicine. However, it might be very hard to imagine how such soft microfluidic devices would be used in other areas, such as electronics, in which stiff, solid metals, insulators, and semiconductors have previously dominated. Very recently, things have radically changed. Taking advantage of native properties of microfluidics, advances in microfluidics-based electronics have shown great potential in numerous new appealing applications, e.g. bio-inspired devices, body-worn healthcare and medical sensing systems, and ergonomic units, in which conventional rigid, bulky electronics are facing insurmountable obstacles to fulfil the demand on comfortable user experience. Not only would the birth of microfluidic electronics contribute to both the microfluidics and electronics fields, but it may also shape the future of our daily life. Nevertheless, microfluidic electronics are still at a very early stage, and significant efforts in research and development are needed to advance this emerging field. The intention of this article is to review recent research outcomes in the field of microfluidic electronics, and address current technical challenges and issues. The outlook of future development in microfluidic electronic devices and systems, as well as new fabrication techniques, is also discussed. Moreover, the authors would like to inspire both the microfluidics and electronics communities to further exploit this newly-established field.

  7. Mechanism of bubble detachment from vibrating walls

    SciTech Connect

    Kim, Dongjun; Park, Jun Kwon Kang, Kwan Hyoung; Kang, In Seok

    2013-11-15

    We discovered a previously unobserved mechanism by which air bubbles detach from vibrating walls in glasses containing water. Chaotic oscillation and subsequent water jets appeared when a wall vibrated at greater than a critical level. Wave forms were developed at water-air interface of the bubble by the wall vibration, and water jets were formed when sufficiently grown wave-curvatures were collapsing. Droplets were pinched off from the tip of jets and fell to the surface of the glass. When the solid-air interface at the bubble-wall attachment point was completely covered with water, the bubble detached from the wall. The water jets were mainly generated by subharmonic waves and were generated most vigorously when the wall vibrated at the volume resonant frequency of the bubble. Bubbles of specific size can be removed by adjusting the frequency of the wall's vibration.

  8. Pulsed laser triggered high speed microfluidic switch

    NASA Astrophysics Data System (ADS)

    Wu, Ting-Hsiang; Gao, Lanyu; Chen, Yue; Wei, Kenneth; Chiou, Pei-Yu

    2008-10-01

    We report a high-speed microfluidic switch capable of achieving a switching time of 10 μs. The switching mechanism is realized by exciting dynamic vapor bubbles with focused laser pulses in a microfluidic polydimethylsiloxane (PDMS) channel. The bubble expansion deforms the elastic PDMS channel wall and squeezes the adjacent sample channel to control its fluid and particle flows as captured by the time-resolved imaging system. A switching of polystyrene microspheres in a Y-shaped channel has also been demonstrated. This ultrafast laser triggered switching mechanism has the potential to advance the sorting speed of state-of-the-art microscale fluorescence activated cell sorting devices.

  9. Manipulating bubbles with secondary Bjerknes forces

    SciTech Connect

    Lanoy, Maxime; Derec, Caroline; Leroy, Valentin; Tourin, Arnaud

    2015-11-23

    Gas bubbles in a sound field are submitted to a radiative force, known as the secondary Bjerknes force. We propose an original experimental setup that allows us to investigate in detail this force between two bubbles, as a function of the sonication frequency, as well as the bubbles radii and distance. We report the observation of both attractive and, more interestingly, repulsive Bjerknes force, when the two bubbles are driven in antiphase. Our experiments show the importance of taking multiple scatterings into account, which leads to a strong acoustic coupling of the bubbles when their radii are similar. Our setup demonstrates the accuracy of secondary Bjerknes forces for attracting or repealing a bubble, and could lead to new acoustic tools for noncontact manipulation in microfluidic devices.

  10. Recalcitrant bubbles

    PubMed Central

    Shanahan, Martin E. R.; Sefiane, Khellil

    2014-01-01

    We demonstrate that thermocapillary forces may drive bubbles against liquid flow in ‘anomalous' mixtures. Unlike ‘ordinary' liquids, in which bubbles migrate towards higher temperatures, we have observed vapour bubbles migrating towards lower temperatures, therefore against the flow. This unusual behaviour may be explained by the temperature dependence of surface tension of these binary mixtures. Bubbles migrating towards their equilibrium position follow an exponential trend. They finally settle in a stationary position just ‘downstream' of the minimum in surface tension. The exponential trend for bubbles in ‘anomalous' mixtures and the linear trend in pure liquids can be explained by a simple model. For larger bubbles, oscillations were observed. These oscillations can be reasonably explained by including an inertial term in the equation of motion (neglected for smaller bubbles). PMID:24740256

  11. Recalcitrant bubbles.

    PubMed

    Shanahan, Martin E R; Sefiane, Khellil

    2014-04-17

    We demonstrate that thermocapillary forces may drive bubbles against liquid flow in 'anomalous' mixtures. Unlike 'ordinary' liquids, in which bubbles migrate towards higher temperatures, we have observed vapour bubbles migrating towards lower temperatures, therefore against the flow. This unusual behaviour may be explained by the temperature dependence of surface tension of these binary mixtures. Bubbles migrating towards their equilibrium position follow an exponential trend. They finally settle in a stationary position just 'downstream' of the minimum in surface tension. The exponential trend for bubbles in 'anomalous' mixtures and the linear trend in pure liquids can be explained by a simple model. For larger bubbles, oscillations were observed. These oscillations can be reasonably explained by including an inertial term in the equation of motion (neglected for smaller bubbles).

  12. Bubble Combustion

    NASA Technical Reports Server (NTRS)

    Corrigan, Jackie

    2004-01-01

    A method of energy production that is capable of low pollutant emissions is fundamental to one of the four pillars of NASA s Aeronautics Blueprint: Revolutionary Vehicles. Bubble combustion, a new engine technology currently being developed at Glenn Research Center promises to provide low emissions combustion in support of NASA s vision under the Emissions Element because it generates power, while minimizing the production of carbon dioxide (CO2) and nitrous oxides (NOx), both known to be Greenhouse gases. and allows the use of alternative fuels such as corn oil, low-grade fuels, and even used motor oil. Bubble combustion is analogous to the inverse of spray combustion: the difference between bubble and spray combustion is that spray combustion is spraying a liquid in to a gas to form droplets, whereas bubble combustion involves injecting a gas into a liquid to form gaseous bubbles. In bubble combustion, the process for the ignition of the bubbles takes place on a time scale of less than a nanosecond and begins with acoustic waves perturbing each bubble. This perturbation causes the local pressure to drop below the vapor pressure of the liquid thus producing cavitation in which the bubble diameter grows, and upon reversal of the oscillating pressure field, the bubble then collapses rapidly with the aid of the high surface tension forces acting on the wall of the bubble. The rapid and violent collapse causes the temperatures inside the bubbles to soar as a result of adiabatic heating. As the temperatures rise, the gaseous contents of the bubble ignite with the bubble itself serving as its own combustion chamber. After ignition, this is the time in the bubble s life cycle where power is generated, and CO2, and NOx among other species, are produced. However, the pollutants CO2 and NOx are absorbed into the surrounding liquid. The importance of bubble combustion is that it generates power using a simple and compact device. We conducted a parametric study using CAVCHEM

  13. Microfluidic biosensors for intelligent metabolite monitoring

    NASA Astrophysics Data System (ADS)

    Radhakrishnan, Nitin; Park, Jongwon; Kim, Chang-Soo

    2007-09-01

    We present an intelligent microfluidic system with oxidase enzyme coupled biosensors. Baseline (zero-value) drift and sensitivity degradation are two common problems related with biosensors. In order to overcome these problems there is a great need for integrating an on-demand, in situ self-diagnosis and self-calibration unit along with the sensor. Utilizing the microfluidic technology, we explore the feasibility of implementing this function without any externally coupled bulky apparatus. A microsystem including a microfluidic channel and calibration electrodes are prepared by microfabrication techniques. A novel method of using hydrogen and oxygen bubbles generated by electrolysis of water is used to saturate the solution with these gases in the microfluidic channel where the biosensor is placed. The hydrogen bubble provides oxygen-depleted microenvironment to conduct a zero-value calibration procedure for the sensor. The oxygen bubble provides high sensitivity and constant oxygen background environment to allow stable enzyme reactions that is not limited or perturbed by the fluctuation of background oxygen in sample solutions. Commercial oxygen sensors and pH sensors are used to confirm whether saturation or depletion of oxygen has occurred with minimum local pH change near the sensor during the electrolytic bubble generation. The glucose data obtained from the experiments assure that our proposed method is promising to overcome the above mentioned two problems.

  14. Microfluidic crystallization.

    PubMed

    Leng, Jacques; Salmon, Jean-Baptiste

    2009-01-01

    Microfluidics offers a wide range of new tools that permit one to revisit the formation of crystals in solution and yield insights into crystallization processes. We review such recent microfluidic devices and particularly emphasize lab-on-chips dedicated to the high-throughput screening of crystallization conditions of proteins with nanolitre consumption. We also thoroughly discuss the possibilities offered by the microfluidic tools to acquire thermodynamic and kinetic data that may improve industrial processes and shed a new light on nucleation and growth mechanisms.

  15. Bubble baryogenesis

    NASA Astrophysics Data System (ADS)

    Cheung, Clifford; Dahlen, Alex; Elor, Gilly

    2012-09-01

    We propose an alternative mechanism of baryogenesis in which a scalar baryon undergoes a percolating first-order phase transition in the early Universe. The potential barrier that divides the phases contains explicit B and CP violation and the corresponding instanton that mediates decay is therefore asymmetric. The nucleation and growth of these asymmetric bubbles dynamically generates baryons, which thermalize after percolation; bubble collision dynamics can also add to the asymmetry yield. We present an explicit toy model that undergoes bubble baryogenesis, and numerically study the evolution of the baryon asymmetry through bubble nucleation and growth, bubble collisions, and washout. We discuss more realistic constructions, in which the scalar baryon and its potential arise amongst the color-breaking minima of the MSSM, or in the supersymmetric neutrino seesaw mechanism. Phenomenological consequences, such as gravitational waves, and possible applications to asymmetric dark-matter generation are also discussed.

  16. Oscillating bubbles: a versatile tool for lab on a chip applications.

    PubMed

    Hashmi, Ali; Yu, Gan; Reilly-Collette, Marina; Heiman, Garrett; Xu, Jie

    2012-11-01

    With the fast development of acoustic and multiphase microfluidics in recent years, oscillating bubbles have drawn more-and-more attention due to their great potential in various Lab on a Chip (LOC) applications. Many innovative bubble-based devices have been explored in the past decade. In this article, we first briefly summarize current understanding of the physics of oscillating bubbles, and then critically summarize recent advancements, including some of our original work, on the applications of oscillating bubbles in microfluidic devices. We intend to highlight the advantages of using oscillating bubbles along with the challenges that accompany them. We believe that these emerging studies on microfluidic oscillating bubbles will be revolutionary to the development of next-generation LOC technologies.

  17. Bubble, Bubble, Toil and Trouble.

    ERIC Educational Resources Information Center

    Journal of Chemical Education, 2001

    2001-01-01

    Bubbles are a fun way to introduce the concepts of surface tension, intermolecular forces, and the use of surfactants. Presents two activities in which students add chemicals to liquid dishwashing detergent with water in order to create longer lasting bubbles. (ASK)

  18. Period-adding bifurcations and chaos in a bubble column.

    PubMed

    Piassi, Viviane S M; Tufaile, Alberto; Sartorelli, Jose Carlos

    2004-06-01

    We obtained period-adding bifurcations in a bubble formation experiment. Using the air flow rate as the control parameter in this experiment, the bubble emission from the nozzle in a viscous fluid undergoes from single bubbling to a sequence of periodic bifurcations of k to k+1 periods, occasionally interspersed with some chaotic regions. Our main assumption is that this period-adding bifurcation in bubble formation depends on flow rate variations in the chamber under the nozzle. This assumption was experimentally tested by placing a tube between the air reservoir and the chamber under the nozzle in the bubble column experiment. By increasing the tube length, more period-adding bifurcations were observed. We associated two main types of bubble growth to the flow rate fluctuations inside the chamber for different bubbling regimes. We also studied the properties of piecewise nonlinear maps obtained from the experimental reconstructed attractors, and we concluded that this experiment is a spatially extended system.

  19. Bubble diagnostics

    DOEpatents

    Visuri, Steven R.; Mammini, Beth M.; Da Silva, Luiz B.; Celliers, Peter M.

    2003-01-01

    The present invention is intended as a means of diagnosing the presence of a gas bubble and incorporating the information into a feedback system for opto-acoustic thrombolysis. In opto-acoustic thrombolysis, pulsed laser radiation at ultrasonic frequencies is delivered intraluminally down an optical fiber and directed toward a thrombus or otherwise occluded vessel. Dissolution of the occlusion is therefore mediated through ultrasonic action of propagating pressure or shock waves. A vapor bubble in the fluid surrounding the occlusion may form as a result of laser irradiation. This vapor bubble may be used to directly disrupt the occlusion or as a means of producing a pressure wave. It is desirable to detect the formation and follow the lifetime of the vapor bubble. Knowledge of the bubble formation and lifetime yields critical information as to the maximum size of the bubble, density of the absorbed radiation, and properties of the absorbing material. This information can then be used in a feedback system to alter the irradiation conditions.

  20. Microfluidic technologies.

    PubMed

    Bhagat, Ali Asgar S; Lim, Chwee Teck

    2012-01-01

    Presence of circulating tumor cells (CTCs) in blood is an important intermediate step in cancer metastasis, a mortal consequence of cancer. However, CTCs are extremely rare in blood with highly heterogeneous morphologies and molecular signatures, thus making their isolation technically very challenging. In the past decade, a flurry of new microfluidic-based technologies has emerged to address this compelling problem. This chapter highlights the current state of the art in microfluidic systems developed for CTCs separation and isolation. The techniques presented are broadly classified as physical- or affinity-based isolation depending on the separation principle. The performance of these techniques is evaluated based on accepted separation metrics including sensitivity, purity and processing/analysis time. Finally, further insights associated with realizing an integrated microfluidic CTC lab-on-chip system as an onco-diagnostic tool will be discussed. PMID:22527494

  1. Stretching cells and delivering drugs with bubbles

    NASA Astrophysics Data System (ADS)

    Ohl, Claus-Dieter; Li, Fenfang; Chon U, Chan; Gao, Yu; Xu, Chenjie

    2015-11-01

    In this talk we'll review our work on impulsive cell stretching using cavitation bubbles and magnetic microbubbles for drug delivery. For sufficient short times cells can sustain a much larger areal strain than the yield strain obtained from quasi-static stretching. Experiments with red blood cells show that even then the rupture of the cell is slow process; it is caused by diffusive swelling rather than mechanical violation of the plasma membrane. In the second part we'll discuss bubbles coated with magnetic and drug loaded particles. These bubbles offer an interesting vector for on demand delivery of drugs using mild ultrasound and magnetic fields. We report on basic experiments in microfluidic channels revealing the release of the agent during bubble oscillations and first in vivo validation with a mouse tumor model. Singapore National Research Foundations Competitive Research Program funding (NRF-CRP9-2011-04).

  2. Collision of counterpropagating laser-excited wake bubbles.

    PubMed

    Deng, Z G; Yang, L; Zhou, C T; Yu, M Y; Ying, H P; Wang, X G

    2014-06-01

    The collision of wake bubbles behind two counterpropagating laser pulses in rarefied plasma is investigated using particle-in-cell simulation. Special attention is paid to the highly nonlinear dynamics of the electrons in the interaction region. It is found that, as the two bubbles approach each other and collide, the electrons in the interaction region first oscillate in a periodic fashion, forming a quasistationary dense electron density ripple with fairly regular spatial structure. At longer times, the electron motion becomes chaotic, and the density grating is gradually smeared. The electrons escape in the transverse direction, and eventually the two bubbles merge to form a single one. The transition of the electron motion from regular to chaotic is confirmed by analytical modeling using test electrons moving in counterpropagating planar electromagnetic waves. The findings shed light on the dynamics of wake-bubble collisions and the complex behavior induced by multiple laser pulses in plasmas.

  3. Synchronization of chaotic systems

    SciTech Connect

    Pecora, Louis M.; Carroll, Thomas L.

    2015-09-15

    We review some of the history and early work in the area of synchronization in chaotic systems. We start with our own discovery of the phenomenon, but go on to establish the historical timeline of this topic back to the earliest known paper. The topic of synchronization of chaotic systems has always been intriguing, since chaotic systems are known to resist synchronization because of their positive Lyapunov exponents. The convergence of the two systems to identical trajectories is a surprise. We show how people originally thought about this process and how the concept of synchronization changed over the years to a more geometric view using synchronization manifolds. We also show that building synchronizing systems leads naturally to engineering more complex systems whose constituents are chaotic, but which can be tuned to output various chaotic signals. We finally end up at a topic that is still in very active exploration today and that is synchronization of dynamical systems in networks of oscillators.

  4. Synchronization of chaotic systems.

    PubMed

    Pecora, Louis M; Carroll, Thomas L

    2015-09-01

    We review some of the history and early work in the area of synchronization in chaotic systems. We start with our own discovery of the phenomenon, but go on to establish the historical timeline of this topic back to the earliest known paper. The topic of synchronization of chaotic systems has always been intriguing, since chaotic systems are known to resist synchronization because of their positive Lyapunov exponents. The convergence of the two systems to identical trajectories is a surprise. We show how people originally thought about this process and how the concept of synchronization changed over the years to a more geometric view using synchronization manifolds. We also show that building synchronizing systems leads naturally to engineering more complex systems whose constituents are chaotic, but which can be tuned to output various chaotic signals. We finally end up at a topic that is still in very active exploration today and that is synchronization of dynamical systems in networks of oscillators.

  5. Mixing of spherical bubbles with time-dependent radius in incompressible flows.

    PubMed

    Pérez-Muñuzuri, Vicente; Garaboa-Paz, Daniel

    2016-02-01

    The motion of contracting and expanding bubbles in an incompressible chaotic flow is analyzed in terms of the finite-time Lyapunov exponents. The viscous forces acting on the bubble surface depend not only on the relative acceleration but also on the time dependence of the bubble volume, which is modeled by the Rayleigh-Plesset equation. The effect of bubble coalescence on the coherent structures that develop in the flow is studied using a simplified bubble merger model. Contraction and expansion of the bubbles is favored in the vicinity of the coherent structures. Time evolution of coalescence bubbles follows a Lévy distribution with an exponent that depends on the initial distance between bubbles. Mixing patterns were found to depend heavily on merging and on the time-dependent volume of the bubbles.

  6. Bubble size measurements in a bubbly wake

    NASA Astrophysics Data System (ADS)

    Karn, Ashish; Hong, Jiarong; Ellis, Christopher; Arndt, Roger

    2014-11-01

    Measurements of bubble size distribution are ubiquitous in many industrial applications. Conventional methods using image analysis to measure bubble size are limited in their robustness and applicability in highly turbulent bubbly flows. These flows usually impose significant challenges for image processing such as a wide range of bubble size distribution, spatial and temporal inhomogeneity of image background including in-focus and out-of-focus bubbles, as well as the excessive presence of bubble clusters. This talk introduces a multi-level image analysis approach to detect a wide size range of bubbles and resolve bubble clusters from images obtained in a turbulent bubbly wake of a ventilated hydrofoil. The proposed approach was implemented to derive bubble size and air ventilation rate from the synthetic images and the experiments, respectively. The results show a great promise in its applicability for online monitoring of bubbly flows in a number of industrial applications. Sponsored by Office of Naval Research and the Department of Energy.

  7. Photothermal generation of microbubbles on plasmonic nanostructures inside microfluidic channels

    NASA Astrophysics Data System (ADS)

    Li, Jingting; Li, Ming; Santos, Greggy M.; Zhao, Fusheng; Shih, Wei-Chuan

    2016-03-01

    Microbubbles have been utilized as micro-pumps, micro-mixers, micro-valves, micro-robots and surface cleaners. Various generation techniques can be found in the literature, including resistive heating, hydrodynamic methods, illuminating patterned metal films and noble metal nanoparticles of Au or Ag. We present photothermal microbubble generation by irradiating nanoporous gold disk covered microfluidic channels. The size of the microbubble can be controlled by adjusting the laser power. The dynamics of both bubble growth and shrinkage are studied. The advantages of this technique are flexible bubble generation locations, long bubble lifetimes, no need for light-adsorbing dyes, high controllability over bubble size, low power consumption, etc. This technique has the potential to provide new flow control functions in microfluidic devices.

  8. Tiny Bubbles.

    ERIC Educational Resources Information Center

    Kim, Hy

    1985-01-01

    A simple oxygen-collecting device (easily constructed from glass jars and a lid) can show bubbles released by water plants during photosynthesis. Suggestions are given for: (1) testing the collected gas; (2) using various carbon dioxide sources; and (3) measuring respiration. (DH)

  9. Leverage bubble

    NASA Astrophysics Data System (ADS)

    Yan, Wanfeng; Woodard, Ryan; Sornette, Didier

    2012-01-01

    Leverage is strongly related to liquidity in a market and lack of liquidity is considered a cause and/or consequence of the recent financial crisis. A repurchase agreement is a financial instrument where a security is sold simultaneously with an agreement to buy it back at a later date. Repurchase agreement (repo) market size is a very important element in calculating the overall leverage in a financial market. Therefore, studying the behavior of repo market size can help to understand a process that can contribute to the birth of a financial crisis. We hypothesize that herding behavior among large investors led to massive over-leveraging through the use of repos, resulting in a bubble (built up over the previous years) and subsequent crash in this market in early 2008. We use the Johansen-Ledoit-Sornette (JLS) model of rational expectation bubbles and behavioral finance to study the dynamics of the repo market that led to the crash. The JLS model qualifies a bubble by the presence of characteristic patterns in the price dynamics, called log-periodic power law (LPPL) behavior. We show that there was significant LPPL behavior in the market before that crash and that the predicted range of times predicted by the model for the end of the bubble is consistent with the observations.

  10. Chaotic Neural Networks and Beyond

    NASA Astrophysics Data System (ADS)

    Aihara, Kazuyuki; Yamada, Taiji; Oku, Makito

    2013-01-01

    A chaotic neuron model which is closely related to deterministic chaos observed experimentally with squid giant axons is explained, and used to construct a chaotic neural network model. Further, such a chaotic neural network is extended to different chaotic models such as a largescale memory relation network, a locally connected network, a vector-valued network, and a quaternionic-valued neuron.

  11. Microfluidic Device

    NASA Technical Reports Server (NTRS)

    Tai, Yu-Chong (Inventor); Zheng, Siyang (Inventor); Lin, Jeffrey Chun-Hui (Inventor); Kasdan, Harvey (Inventor)

    2015-01-01

    Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations. One particular embodiment relates a device and methods of using the same for sensing, counting, and/or sorting leukocytes from whole, undiluted blood samples.

  12. Microfluidic Device

    NASA Technical Reports Server (NTRS)

    Tai, Yu-Chong (Inventor); Zheng, Siyang (Inventor); Lin, Jeffrey Chun-Hui (Inventor); Kasdan, Harvey L. (Inventor)

    2016-01-01

    Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations. One particular embodiment relates a device and methods of using the same for sensing, counting, and/or sorting leukocytes from whole, undiluted blood samples.

  13. Bubbles navigating through networks of microchannels.

    PubMed

    Choi, Wonjae; Hashimoto, Michinao; Ellerbee, Audrey K; Chen, Xin; Bishop, Kyle J M; Garstecki, Piotr; Stone, Howard A; Whitesides, George M

    2011-12-01

    This paper describes the behavior of bubbles suspended in a carrier liquid and moving within microfluidic networks of different connectivities. A single-phase continuum fluid, when flowing in a network of channels, partitions itself among all possible paths connecting the inlet and outlet. The flow rates along different paths are determined by the interaction between the fluid and the global structure of the network. That is, the distribution of flows depends on the fluidic resistances of all channels of the network. The movement of bubbles of gas, or droplets of liquid, suspended in a liquid can be quite different from the movement of a single-phase liquid, especially when they have sizes slightly larger than the channels, so that the bubbles (or droplets) contribute to the fluidic resistance of a channel when they are transiting it. This paper examines bubbles in this size range; in the size range examined, the bubbles are discrete and do not divide at junctions. As a consequence, a single bubble traverses only one of the possible paths through the network, and makes a sequence of binary choices ("left" or "right") at each branching intersection it encounters. We designed networks so that, at each junction, a bubble enters the channel into which the volumetric flow rate of the carrier liquid is highest. When there is only a single bubble inside a network at a time, the path taken by the bubble is, counter-intuitively, not necessarily the shortest or the fastest connecting the inlet and outlet. When a small number of bubbles move simultaneously through a network, they interact with one another by modifying fluidic resistances and flows in a time dependent manner; such groups of bubbles show very complex behaviors. When a large number of bubbles (sufficiently large that the volume of the bubbles occupies a significant fraction of the volume of the network) flow simultaneously through a network, however, the collective behavior of bubbles-the fluxes of bubbles

  14. Expanding Imaging Capabilities for Microfluidics: Applicability of Darkfield Internal Reflection Illumination (DIRI) to Observations in Microfluidics

    PubMed Central

    Kawano, Yoshihiro; Otsuka, Chino; Sanzo, James; Higgins, Christopher; Nirei, Tatsuo; Schilling, Tobias; Ishikawa, Takuji

    2015-01-01

    Microfluidics is used increasingly for engineering and biomedical applications due to recent advances in microfabrication technologies. Visualization of bubbles, tracer particles, and cells in a microfluidic device is important for designing a device and analyzing results. However, with conventional methods, it is difficult to observe the channel geometry and such particles simultaneously. To overcome this limitation, we developed a Darkfield Internal Reflection Illumination (DIRI) system that improved the drawbacks of a conventional darkfield illuminator. This study was performed to investigate its utility in the field of microfluidics. The results showed that the developed system could clearly visualize both microbubbles and the channel wall by utilizing brightfield and DIRI illumination simultaneously. The methodology is useful not only for static phenomena, such as clogging, but also for dynamic phenomena, such as the detection of bubbles flowing in a channel. The system was also applied to simultaneous fluorescence and DIRI imaging. Fluorescent tracer beads and channel walls were observed clearly, which may be an advantage for future microparticle image velocimetry (μPIV) analysis, especially near a wall. Two types of cell stained with different colors, and the channel wall, can be recognized using the combined confocal and DIRI system. Whole-slide imaging was also conducted successfully using this system. The tiling function significantly expands the observing area of microfluidics. The developed system will be useful for a wide variety of engineering and biomedical applications for the growing field of microfluidics. PMID:25748425

  15. Expanding imaging capabilities for microfluidics: applicability of darkfield internal reflection illumination (DIRI) to observations in microfluidics.

    PubMed

    Kawano, Yoshihiro; Otsuka, Chino; Sanzo, James; Higgins, Christopher; Nirei, Tatsuo; Schilling, Tobias; Ishikawa, Takuji

    2015-01-01

    Microfluidics is used increasingly for engineering and biomedical applications due to recent advances in microfabrication technologies. Visualization of bubbles, tracer particles, and cells in a microfluidic device is important for designing a device and analyzing results. However, with conventional methods, it is difficult to observe the channel geometry and such particles simultaneously. To overcome this limitation, we developed a Darkfield Internal Reflection Illumination (DIRI) system that improved the drawbacks of a conventional darkfield illuminator. This study was performed to investigate its utility in the field of microfluidics. The results showed that the developed system could clearly visualize both microbubbles and the channel wall by utilizing brightfield and DIRI illumination simultaneously. The methodology is useful not only for static phenomena, such as clogging, but also for dynamic phenomena, such as the detection of bubbles flowing in a channel. The system was also applied to simultaneous fluorescence and DIRI imaging. Fluorescent tracer beads and channel walls were observed clearly, which may be an advantage for future microparticle image velocimetry (μPIV) analysis, especially near a wall. Two types of cell stained with different colors, and the channel wall, can be recognized using the combined confocal and DIRI system. Whole-slide imaging was also conducted successfully using this system. The tiling function significantly expands the observing area of microfluidics. The developed system will be useful for a wide variety of engineering and biomedical applications for the growing field of microfluidics.

  16. Bubble Drag Reduction Requires Large Bubbles

    NASA Astrophysics Data System (ADS)

    Verschoof, Ruben A.; van der Veen, Roeland C. A.; Sun, Chao; Lohse, Detlef

    2016-09-01

    In the maritime industry, the injection of air bubbles into the turbulent boundary layer under the ship hull is seen as one of the most promising techniques to reduce the overall fuel consumption. However, the exact mechanism behind bubble drag reduction is unknown. Here we show that bubble drag reduction in turbulent flow dramatically depends on the bubble size. By adding minute concentrations (6 ppm) of the surfactant Triton X-100 into otherwise completely unchanged strongly turbulent Taylor-Couette flow containing bubbles, we dramatically reduce the drag reduction from more than 40% to about 4%, corresponding to the trivial effect of the bubbles on the density and viscosity of the liquid. The reason for this striking behavior is that the addition of surfactants prevents bubble coalescence, leading to much smaller bubbles. Our result demonstrates that bubble deformability is crucial for bubble drag reduction in turbulent flow and opens the door for an optimization of the process.

  17. Bubble Drag Reduction Requires Large Bubbles.

    PubMed

    Verschoof, Ruben A; van der Veen, Roeland C A; Sun, Chao; Lohse, Detlef

    2016-09-01

    In the maritime industry, the injection of air bubbles into the turbulent boundary layer under the ship hull is seen as one of the most promising techniques to reduce the overall fuel consumption. However, the exact mechanism behind bubble drag reduction is unknown. Here we show that bubble drag reduction in turbulent flow dramatically depends on the bubble size. By adding minute concentrations (6 ppm) of the surfactant Triton X-100 into otherwise completely unchanged strongly turbulent Taylor-Couette flow containing bubbles, we dramatically reduce the drag reduction from more than 40% to about 4%, corresponding to the trivial effect of the bubbles on the density and viscosity of the liquid. The reason for this striking behavior is that the addition of surfactants prevents bubble coalescence, leading to much smaller bubbles. Our result demonstrates that bubble deformability is crucial for bubble drag reduction in turbulent flow and opens the door for an optimization of the process.

  18. Bubble Drag Reduction Requires Large Bubbles.

    PubMed

    Verschoof, Ruben A; van der Veen, Roeland C A; Sun, Chao; Lohse, Detlef

    2016-09-01

    In the maritime industry, the injection of air bubbles into the turbulent boundary layer under the ship hull is seen as one of the most promising techniques to reduce the overall fuel consumption. However, the exact mechanism behind bubble drag reduction is unknown. Here we show that bubble drag reduction in turbulent flow dramatically depends on the bubble size. By adding minute concentrations (6 ppm) of the surfactant Triton X-100 into otherwise completely unchanged strongly turbulent Taylor-Couette flow containing bubbles, we dramatically reduce the drag reduction from more than 40% to about 4%, corresponding to the trivial effect of the bubbles on the density and viscosity of the liquid. The reason for this striking behavior is that the addition of surfactants prevents bubble coalescence, leading to much smaller bubbles. Our result demonstrates that bubble deformability is crucial for bubble drag reduction in turbulent flow and opens the door for an optimization of the process. PMID:27636479

  19. Cascade Chaotic System With Applications.

    PubMed

    Zhou, Yicong; Hua, Zhongyun; Pun, Chi-Man; Chen, C L Philip

    2015-09-01

    Chaotic maps are widely used in different applications. Motivated by the cascade structure in electronic circuits, this paper introduces a general chaotic framework called the cascade chaotic system (CCS). Using two 1-D chaotic maps as seed maps, CCS is able to generate a huge number of new chaotic maps. Examples and evaluations show the CCS's robustness. Compared with corresponding seed maps, newly generated chaotic maps are more unpredictable and have better chaotic performance, more parameters, and complex chaotic properties. To investigate applications of CCS, we introduce a pseudo-random number generator (PRNG) and a data encryption system using a chaotic map generated by CCS. Simulation and analysis demonstrate that the proposed PRNG has high quality of randomness and that the data encryption system is able to protect different types of data with a high-security level.

  20. Microfluidic interconnects

    DOEpatents

    Benett, William J.; Krulevitch, Peter A.

    2001-01-01

    A miniature connector for introducing microliter quantities of solutions into microfabricated fluidic devices. The fluidic connector, for example, joins standard high pressure liquid chromatography (HPLC) tubing to 1 mm diameter holes in silicon or glass, enabling ml-sized volumes of sample solutions to be merged with .mu.l-sized devices. The connector has many features, including ease of connect and disconnect; a small footprint which enables numerous connectors to be located in a small area; low dead volume; helium leak-tight; and tubing does not twist during connection. Thus the connector enables easy and effective change of microfluidic devices and introduction of different solutions in the devices.

  1. Magma mixing enhanced by bubble ascent

    NASA Astrophysics Data System (ADS)

    Wiesmaier, S.; Morgavi, D.; Perugini, D.; De Campos, C. P.; Hess, K.; Lavallee, Y.; Dingwell, D. B.

    2012-12-01

    progressive loss of advected basalt during bubble motion was quantified by microCT for defined viscosity couples. The diffusional gradient around the plume tail showed a progressive evolution of equilibration from bottom to top of the plume tail. A future aim is to compute the impact of bubble motion on the efficiency of magma mixing in dependence of volatile solubilities and pressure and viscosity variations. This has implications for the capacity of magma to produce bubbles in e.g. stratified magma chambers. [1] De Campos, C., D. Perugini, W. Ertel-Ingrisch, D. Dingwell, and G. Poli (2011), Enhancement of magma mixing efficiency by chaotic dynamics: an experimental study, Contrib. Mineral. Petrol., 161(6), 863-881. [2] Thomas, N., S. Tait, and T. Koyaguchi (1993), Mixing of stratified liquids by the motion of gas bubbles: application to magma mixing, Earth Planet. Sci. Lett., 115(1-4), 161-175.

  2. Improving electrokinetic microdevice stability by controlling electrolysis bubbles.

    PubMed

    Lee, Hwi Yong; Barber, Cedrick; Minerick, Adrienne R

    2014-07-01

    The voltage-operating window for many electrokinetic microdevices is limited by electrolysis gas bubbles that destabilize microfluidic system causing noise and irreproducible responses above ∼3 V DC and less than ∼1 kHz AC at 3 Vpp. Surfactant additives, SDS and Triton X-100, and an integrated semipermeable SnakeSkin® membrane were employed to control and assess electrolysis bubbles from platinum electrodes in a 180 by 70 μm, 10 mm long microchannel. Stabilized current responses at 100 V DC were observed with surfactant additives or SnakeSkin® barriers. Electrolysis bubble behaviors, visualized via video microscopy at the electrode surface and in the microchannels, were found to be influenced by surfactant function and SnakeSkin® barriers. Both SDS and Triton X-100 surfactants promoted smaller bubble diameters and faster bubble detachment from electrode surfaces via increasing gas solubility. In contrast, SnakeSkin® membranes enhanced natural convection and blocked bubbles from entering the microchannels and thus reduced current disturbances in the electric field. This data illustrated that electrode surface behaviors had substantially greater impacts on current stability than microbubbles within microchannels. Thus, physically blocking bubbles from microchannels is less effective than electrode functionalization approaches to stabilize electrokinetic microfluidic systems. PMID:24648277

  3. Improving electrokinetic microdevice stability by controlling electrolysis bubbles.

    PubMed

    Lee, Hwi Yong; Barber, Cedrick; Minerick, Adrienne R

    2014-07-01

    The voltage-operating window for many electrokinetic microdevices is limited by electrolysis gas bubbles that destabilize microfluidic system causing noise and irreproducible responses above ∼3 V DC and less than ∼1 kHz AC at 3 Vpp. Surfactant additives, SDS and Triton X-100, and an integrated semipermeable SnakeSkin® membrane were employed to control and assess electrolysis bubbles from platinum electrodes in a 180 by 70 μm, 10 mm long microchannel. Stabilized current responses at 100 V DC were observed with surfactant additives or SnakeSkin® barriers. Electrolysis bubble behaviors, visualized via video microscopy at the electrode surface and in the microchannels, were found to be influenced by surfactant function and SnakeSkin® barriers. Both SDS and Triton X-100 surfactants promoted smaller bubble diameters and faster bubble detachment from electrode surfaces via increasing gas solubility. In contrast, SnakeSkin® membranes enhanced natural convection and blocked bubbles from entering the microchannels and thus reduced current disturbances in the electric field. This data illustrated that electrode surface behaviors had substantially greater impacts on current stability than microbubbles within microchannels. Thus, physically blocking bubbles from microchannels is less effective than electrode functionalization approaches to stabilize electrokinetic microfluidic systems.

  4. Droplet microfluidics.

    PubMed

    Teh, Shia-Yen; Lin, Robert; Hung, Lung-Hsin; Lee, Abraham P

    2008-02-01

    Droplet-based microfluidic systems have been shown to be compatible with many chemical and biological reagents and capable of performing a variety of "digital fluidic" operations that can be rendered programmable and reconfigurable. This platform has dimensional scaling benefits that have enabled controlled and rapid mixing of fluids in the droplet reactors, resulting in decreased reaction times. This, coupled with the precise generation and repeatability of droplet operations, has made the droplet-based microfluidic system a potent high throughput platform for biomedical research and applications. In addition to being used as microreactors ranging from the nano- to femtoliter range; droplet-based systems have also been used to directly synthesize particles and encapsulate many biological entities for biomedicine and biotechnology applications. This review will focus on the various droplet operations, as well as the numerous applications of the system. Due to advantages unique to droplet-based systems, this technology has the potential to provide novel solutions to today's biomedical engineering challenges for advanced diagnostics and therapeutics.

  5. Bifurcation analysis of bubble dynamics in fluidized beds

    SciTech Connect

    Blomgren, Peter; Palacios, Antonio; Zhu, Bing; Daw, C Stuart; FINNEY, Charles E A; Halow, John; Pannala, Sreekanth

    2007-01-01

    We use a low-dimensional, agent-based bubble model to study the changes in the global dynamics of fluidized beds in response to changes in the frequency of the rising bubbles. The computationally based bifurcation analysis shows that at low frequencies, the global dynamics is attracted towards a fixed point since the bubbles interact very little with one another. As the frequency of injection increases, however, the global dynamics undergoes a series of bifurcations to new behaviors that include highly periodic orbits, chaotic attractors, and intermittent behavior between periodic orbits and chaotic sets. Using methods from time-series analysis, we are able to approximate nonlinear models that allow for long-term predictions and the possibility of developing control algorithms.

  6. Bubble bath soap poisoning

    MedlinePlus

    ... medlineplus.gov/ency/article/002762.htm Bubble bath soap poisoning To use the sharing features on this page, please enable JavaScript. Bubble bath soap poisoning occurs when someone swallows bubble bath soap. ...

  7. Discrete Bubble Modeling for Cavitation Bubbles

    NASA Astrophysics Data System (ADS)

    Choi, Jin-Keun; Chahine, Georges; Hsiao, Chao-Tsung

    2007-03-01

    Dynaflow, Inc. has conducted extensive studies on non-spherical bubble dynamics and interactions with solid and free boundaries, vortical flow structures, and other bubbles. From these studies, emerged a simplified Surface Averaged Pressure (SAP) spherical bubble dynamics model and a Lagrangian bubble tracking scheme. In this SAP scheme, the pressure and velocity of the surrounding flow field are averaged on the bubble surface, and then used for the bubble motion and volume dynamics calculations. This model is implemented using the Fluent User Defined Function (UDF) as Discrete Bubble Model (DBM). The Bubble dynamics portion can be solved using an incompressible liquid modified Rayleigh-Plesset equation or a compressible liquid modified Gilmore equation. The Discrete Bubble Model is a very suitable tool for the studies on cavitation inception of foils and turbo machinery, bubble nuclei effects, noise from the bubbles, and can be used in many practical problems in industrial and naval applications associated with flows in pipes, jets, pumps, propellers, ships, and the ocean. Applications to propeller cavitation, wake signatures of waterjet propelled ships, bubble-wake interactions, modeling of cavitating jets, and bubble entrainments around a ship will be presented.

  8. Active micromachines: Microfluidics powered by mesoscale turbulence.

    PubMed

    Thampi, Sumesh P; Doostmohammadi, Amin; Shendruk, Tyler N; Golestanian, Ramin; Yeomans, Julia M

    2016-07-01

    Dense active matter, from bacterial suspensions and microtubule bundles driven by motor proteins to cellular monolayers and synthetic Janus particles, is characterized by mesoscale turbulence, which is the emergence of chaotic flow structures. By immersing an ordered array of symmetric rotors in an active fluid, we introduce a microfluidic system that exploits spontaneous symmetry breaking in mesoscale turbulence to generate work. The lattice of rotors self-organizes into a spin state where neighboring discs continuously rotate in permanent alternating directions due to combined hydrodynamic and elastic effects. Our virtual prototype demonstrates a new research direction for the design of micromachines powered by the nematohydrodynamic properties of active turbulence.

  9. Active micromachines: Microfluidics powered by mesoscale turbulence

    PubMed Central

    Thampi, Sumesh P.; Doostmohammadi, Amin; Shendruk, Tyler N.; Golestanian, Ramin; Yeomans, Julia M.

    2016-01-01

    Dense active matter, from bacterial suspensions and microtubule bundles driven by motor proteins to cellular monolayers and synthetic Janus particles, is characterized by mesoscale turbulence, which is the emergence of chaotic flow structures. By immersing an ordered array of symmetric rotors in an active fluid, we introduce a microfluidic system that exploits spontaneous symmetry breaking in mesoscale turbulence to generate work. The lattice of rotors self-organizes into a spin state where neighboring discs continuously rotate in permanent alternating directions due to combined hydrodynamic and elastic effects. Our virtual prototype demonstrates a new research direction for the design of micromachines powered by the nematohydrodynamic properties of active turbulence. PMID:27419229

  10. Microfluidic electrochemical reactors

    DOEpatents

    Nuzzo, Ralph G.; Mitrovski, Svetlana M.

    2011-03-22

    A microfluidic electrochemical reactor includes an electrode and one or more microfluidic channels on the electrode, where the microfluidic channels are covered with a membrane containing a gas permeable polymer. The distance between the electrode and the membrane is less than 500 micrometers. The microfluidic electrochemical reactor can provide for increased reaction rates in electrochemical reactions using a gaseous reactant, as compared to conventional electrochemical cells. Microfluidic electrochemical reactors can be incorporated into devices for applications such as fuel cells, electrochemical analysis, microfluidic actuation, pH gradient formation.

  11. Chaotic neural control

    NASA Astrophysics Data System (ADS)

    Potapov, A.; Ali, M. K.

    2001-04-01

    We consider the problem of stabilizing unstable equilibria by discrete controls (the controls take discrete values at discrete moments of time). We prove that discrete control typically creates a chaotic attractor in the vicinity of an equilibrium. Artificial neural networks with reinforcement learning are known to be able to learn such a control scheme. We consider examples of such systems, discuss some details of implementing the reinforcement learning to controlling unstable equilibria, and show that the arising dynamics is characterized by positive Lyapunov exponents, and hence is chaotic. This chaos can be observed both in the controlled system and in the activity patterns of the controller.

  12. Microfluidic interconnects

    DOEpatents

    Benett, William J.; Krulevitch, Peter A.

    2001-01-01

    A miniature connector for introducing microliter quantities of solutions into microfabricated fluidic devices, and which incorporates a molded ring or seal set into a ferrule cartridge, with or without a compression screw. The fluidic connector, for example, joins standard high pressure liquid chromatography (HPLC) tubing to 1 mm diameter holes in silicon or glass, enabling ml-sized volumes of sample solutions to be merged with .mu.l-sized devices. The connector has many features, including ease of connect and disconnect; a small footprint which enables numerous connectors to be located in a small area; low dead volume; helium leak-tight; and tubing does not twist during connection. Thus the connector enables easy and effective change of microfluidic devices and introduction of different solutions in the devices.

  13. Single Bubble Sonoluminescence

    NASA Astrophysics Data System (ADS)

    Farley, Jennifer; Hough, Shane

    2003-05-01

    Single Bubble Sonoluminescence is the emission of light from a single bubble suspended in a liquid caused by a continuum of repeated implosions due to pressure waves generated from a maintained ultrasonic sinusoidal wave source. H. Frenzel and H. Schultz first studied it in 1934 at the University of Cologne. It was not until 1988 with D.F. Gaitan that actual research began with single bubble sonoluminescence. Currently many theories exist attempting to explain the observed bubble phenomenon. Many of these theories require spherical behavior of the bubble. Observation of the bubble has shown that the bubble does not behave spherically in most cases. One explanation for this is known as jet theory. A spectrum of the bubble will give us the mean physical properties of the bubble such as temperature and pressure inside the bubble. Eventually, with the aide of fluorocene dye a full spectrum of the bubble will be obtained.

  14. Chaotic Polynomial Maps

    NASA Astrophysics Data System (ADS)

    Zhang, Xu

    This paper introduces a class of polynomial maps in Euclidean spaces, investigates the conditions under which there exist Smale horseshoes and uniformly hyperbolic invariant sets, studies the chaotic dynamical behavior and strange attractors, and shows that some maps are chaotic in the sense of Li-Yorke or Devaney. This type of maps includes both the Logistic map and the Hénon map. For some diffeomorphisms with the expansion dimension equal to one or two in three-dimensional spaces, the conditions under which there exist Smale horseshoes and uniformly hyperbolic invariant sets on which the systems are topologically conjugate to the two-sided fullshift on finite alphabet are obtained; for some expanding maps, the chaotic region is analyzed by using the coupled-expansion theory and the Brouwer degree theory. For three types of higher-dimensional polynomial maps with degree two, the conditions under which there are Smale horseshoes and uniformly hyperbolic invariant sets are given, and the topological conjugacy between the maps on the invariant sets and the two-sided fullshift on finite alphabet is obtained. Some interesting maps with chaotic attractors and positive Lyapunov exponents in three-dimensional spaces are found by using computer simulations. In the end, two examples are provided to illustrate the theoretical results.

  15. Acoustic bubble removal method

    NASA Technical Reports Server (NTRS)

    Trinh, E. H.; Elleman, D. D.; Wang, T. G. (Inventor)

    1983-01-01

    A method is described for removing bubbles from a liquid bath such as a bath of molten glass to be used for optical elements. Larger bubbles are first removed by applying acoustic energy resonant to a bath dimension to drive the larger bubbles toward a pressure well where the bubbles can coalesce and then be more easily removed. Thereafter, submillimeter bubbles are removed by applying acoustic energy of frequencies resonant to the small bubbles to oscillate them and thereby stir liquid immediately about the bubbles to facilitate their breakup and absorption into the liquid.

  16. Chaotic mixing by microswimmers moving on quasiperiodic orbits

    NASA Astrophysics Data System (ADS)

    Jalali, Mir Abbas; Khoshnood, Atefeh; Alam, Mohammad-Reza

    2015-11-01

    Life on the Earth is strongly dependent upon mixing across a vast range of scales. For example, mixing distributes nutrients for microorganisms in aquatic environments, and balances the spatial energy distribution in the oceans and the atmosphere. From industrial point of view, mixing is essential in many microfluidic processes and lab-on-a-chip operations, polymer engineering, pharmaceutics, food engineering, petroleum engineering, and biotechnology. Efficient mixing, typically characterized by chaotic advection, is hard to achieve in low Reynolds number conditions because of the linear nature of the Stokes equation that governs the motion. We report the first demonstration of chaotic mixing induced by a microswimmer that strokes on quasiperiodic orbits with multi-loop turning paths. Our findings can be utilized to understand the interactions of microorganisms with their environments, and to design autonomous robotic mixers that can sweep and mix an entire volume of complex-geometry containers.

  17. Microfluidic sieve valves

    DOEpatents

    Quake, Stephen R; Marcus, Joshua S; Hansen, Carl L

    2015-01-13

    Sieve valves for use in microfluidic device are provided. The valves are useful for impeding the flow of particles, such as chromatography beads or cells, in a microfluidic channel while allowing liquid solution to pass through the valve. The valves find particular use in making microfluidic chromatography modules.

  18. Optically actuated thermocapillary movement of gas bubbles on an absorbing substrate.

    PubMed

    Ohta, Aaron T; Jamshidi, Arash; Valley, Justin K; Hsu, Hsan-Yin; Wu, Ming C

    2007-08-14

    The authors demonstrate an optical manipulation mechanism of gas bubbles for microfluidic applications. Air bubbles in a silicone oil medium are manipulated via thermocapillary forces generated by the absorption of a laser in an amorphous silicon thin film. In contrast to previous demonstrations of optically controlled thermally driven bubble movement, transparent liquids can be used, as the thermal gradient is formed from laser absorption in the amorphous silicon substrate, and not in the liquid. A variety of bubbles with volumes ranging from 19 pl to 23 nl was transported at measured velocities of up to 1.5 mm/s.

  19. Microfluidic perfusion culture.

    PubMed

    Hattori, Koji; Sugiura, Shinji; Kanamori, Toshiyuki

    2014-01-01

    Microfluidic perfusion culture is a novel technique to culture animal cells in a small-scale microchamber with medium perfusion. Polydimethylsiloxane (PDMS) is the most popular material to fabricate a microfluidic perfusion culture chip. Photolithography and replica molding techniques are generally used for fabrication of a microfluidic perfusion culture chip. Pressure-driven perfusion culture system is convenient technique to carry out the perfusion culture of animal cells in a microfluidic device. Here, we describe a general theory on microfluid network design, microfabrication technique, and experimental technique for pressure-driven perfusion culture in an 8 × 8 microchamber array on a glass slide-sized microchip made out of PDMS. PMID:24297421

  20. Natural chaotic inflation

    NASA Astrophysics Data System (ADS)

    Papantonopoulos, E.; Uematsu, T.; Yanagida, T.

    1987-01-01

    We present a chaotic inflationary model, in which nonlinear interactions of dilaton and axion fields in the context of the superconformal theory can dynamically give rise to initial conditions for the inflation of the universe and a flat potential that can produce enough inflation. Our model is free from dangerous thermal effects and large energy density fluctuations. On leave from Physics Department, College of General Education, Tohoku University, Sendai 980, Japan

  1. Plasmonic nanoshell synthesis in microfluidic composite foams.

    PubMed

    Duraiswamy, Suhanya; Khan, Saif A

    2010-09-01

    The availability of robust, scalable, and automated nanoparticle manufacturing processes is crucial for the viability of emerging nanotechnologies. Metallic nanoparticles of diverse shape and composition are commonly manufactured by solution-phase colloidal chemistry methods, where rapid reaction kinetics and physical processes such as mixing are inextricably coupled, and scale-up often poses insurmountable problems. Here we present the first continuous flow process to synthesize thin gold "nanoshells" and "nanoislands" on colloidal silica surfaces, which are nanoparticle motifs of considerable interest in plasmonics-based applications. We assemble an ordered, flowing composite foam lattice in a simple microfluidic device, where the lattice cells are alternately aqueous drops containing reagents for nanoparticle synthesis or gas bubbles. Microfluidic foam generation enables precisely controlled reagent dispensing and mixing, and the ordered foam structure facilitates compartmentalized nanoparticle growth. This is a general method for aqueous colloidal synthesis, enabling continuous, inherently digital, scalable, and automated production processes for plasmonic nanomaterials.

  2. Engineering synchronization of chaotic oscillators

    SciTech Connect

    Padmanaban, E.; Dana, Syamal K.

    2011-04-19

    We propose a controller based coupling design for engineering synchronization in chaotic oscillators for unidirectional as well as bi-directional mode. In the synchronization regimes, it is possible to amplify/ attenuate a chaotic attractor with respect to other chaotic attractors. Numerical examples are presented for a Lorenz system, a Roessler oscillator, and a Sprott system. Physical implementation of the scheme is done in electronic circuit to design the controller for verification of the theory.

  3. Optimal inference with chaotic dynamics

    NASA Technical Reports Server (NTRS)

    Harger, R. O.

    1983-01-01

    Nonlinear mappings that exhibit chaotic, seemingly random, evolution have appeal as models of dynamic systems. Their deterministic evolution, vis-a-vis Markov evolutions, results in much simpler optimal detection and estimation algorithms. The variation of a chaotic parameter (mu) results in diverse evolutions, suggesting a simple but rich source of model variations. For the specific mapping examined, this latter possibility is problematic due to the extreme sensitivity on mu of the evolution in the chaotic regime.

  4. The chaotic obliquity of Mars

    NASA Technical Reports Server (NTRS)

    Touma, Jihad; Wisdom, Jack

    1993-01-01

    The discovery (by Laskar, 1989, 1990) that the evolution of the solar system is chaotic, made in a numerical integration of the averaged secular approximation of the equations of motions for the planets, was confirmed by Sussman and Wisdom (1992) by direct numerical integration of the whole solar system. This paper presents results of direct integrations of the rotation of Mars in the chaotically evolved planetary system, made using the same model as that used by Sussman and Wisdom. The numerical integration shows that the obliquity of Mars undergoes large chaotic variations, which occur as the system evolves in the chaotic zone associated with a secular spin-orbit resonance.

  5. Microstructure fabrication on glasses for microfluidics

    NASA Astrophysics Data System (ADS)

    Chen, Qiuping; Chen, Qiuling; Liao, Guihua; Milanese, Daniel

    2008-12-01

    Micro-channels were fabricated in sodalime glass through imprinting, and then joined to a glass slab by thermal assisted direct bonding (TADB). These techniques are simple and low cost, suitable for mass production of micro-fluidic devices. The joined samples were characterized before and after TADB by optical microscopy, profilometer, SEM, shear strength test and Vickers hardness test. The integrity of channels is maintained also after the TADB. The interface between the two glass slabs was found to be without impurities, bubbles and cracks. The bonding strength was also measured to be 31.94MPa.

  6. Soap Bubbles and Logic.

    ERIC Educational Resources Information Center

    Levine, Shellie-helane; And Others

    1986-01-01

    Introduces questions and activities involving soap bubbles which provide students with experiences in prediction and logic. Examines commonly held false conceptions related to the shapes that bubbles take and provides correct explanations for the phenomenon. (ML)

  7. Dynamics, Analysis and Implementation of a Multiscroll Memristor-Based Chaotic Circuit

    NASA Astrophysics Data System (ADS)

    Alombah, N. Henry; Fotsin, Hilaire; Ngouonkadi, E. B. Megam; Nguazon, Tekou

    This article introduces a novel four-dimensional autonomous multiscroll chaotic circuit which is derived from the actual simplest memristor-based chaotic circuit. A fourth circuit element — another inductor — is introduced to generate the complex behavior observed. A systematic study of the chaotic behavior is performed with the help of some nonlinear tools such as Lyapunov exponents, phase portraits, and bifurcation diagrams. Multiple scroll attractors are observed in Matlab, Pspice environments and also experimentally. We also observe the phenomenon of antimonotonicity, periodic and chaotic bubbles, multiple periodic-doubling bifurcations, Hopf bifurcations, crises and the phenomenon of intermittency. The chaotic dynamics of this circuit is realized by laboratory experiments, Pspice simulations, numerical and analytical investigations. It is observed that the results from the three environments agree to a great extent. This topology is likely convenient to be used to intentionally generate chaos in memristor-based chaotic circuit applications, given the fact that multiscroll chaotic systems have found important applications as broadband signal generators, pseudorandom number generators for communication engineering and also in biometric authentication.

  8. Preheating in bubble collisions

    SciTech Connect

    Zhang Jun; Piao Yunsong

    2010-08-15

    In a landscape with metastable minima, the bubbles will inevitably nucleate. We show that when the bubbles collide, due to the dramatic oscillation of the field at the collision region, the energy deposited in the bubble walls can be efficiently released by the explosive production of the particles. In this sense, the collision of bubbles is actually highly inelastic. The cosmological implications of this result are discussed.

  9. Soap Films and Bubbles.

    ERIC Educational Resources Information Center

    Rice, Karen

    1986-01-01

    Develops and explains a format for a workshop which focuses on soap films and bubbles. The plan consists of: a discussion to uncover what children know about bubbles; explanations of the demonstration equipment; the presentation itself; the assembly of the workshop kit; and time to play with the bubbles. (ML)

  10. Brut: Automatic bubble classifier

    NASA Astrophysics Data System (ADS)

    Beaumont, Christopher; Goodman, Alyssa; Williams, Jonathan; Kendrew, Sarah; Simpson, Robert

    2014-07-01

    Brut, written in Python, identifies bubbles in infrared images of the Galactic midplane; it uses a database of known bubbles from the Milky Way Project and Spitzer images to build an automatic bubble classifier. The classifier is based on the Random Forest algorithm, and uses the WiseRF implementation of this algorithm.

  11. Chaotic Footloose Capital.

    PubMed

    Commendatore, Pasquale; Currie, Martin; Kubin, Ingrid

    2007-04-01

    This paper examines the long-term behavior of a discrete-time Footloose Capital model, where capitalists, who are themselves immobile between regions, move their physical capital between regions in response to economic incentives. The spatial location of industry can exhibit cycles of any periodicity or behave chaotically. Long-term behavior is highly sensitive to transport costs and to the responsiveness of capitalists to profit differentials. The concentration of industry in one region can result from high transport costs or from rapid responses by capitalists. In terms of possible dynamical behaviors, the discrete-time model is much richer than the standard continuous-time Footloose Capital model.

  12. Nearly discontinuous chaotic mixing

    SciTech Connect

    Sharp, David Howland; Lim, Hyun K; Yu, Yan; Glimm, James G

    2009-01-01

    A new scientific approach is presented for a broad class of chaotic problems involving a high degree of mixing over rapid time scales. Rayleigh-Taylor and Richtmyer-Meshkov unstable flows are typical of such problems. Microscopic mixing properties such as chemical reaction rates for turbulent mixtures can be obtained with feasible grid resolution. The essential dependence of (some) fluid mixing observables on transport phenomena is observed. This dependence includes numerical as well as physical transport and it includes laminar as well as turbulent transport. A new approach to the mathematical theory for the underlying equations is suggested.

  13. Chaotic rotation of Hyperion?

    NASA Technical Reports Server (NTRS)

    Binzel, R. P.; Green, J. R.; Opal, C. B.

    1986-01-01

    Thomas et al. (1984) analyzed 14 Voyager 2 images of Saturn's satellite Hyperion and interpreted them to be consistent with a coherent (nonchaotic) rotation period of 13.1 days. This interpretation was criticized by Peale and Wisdom (1984), who argued that the low sampling frequency of Voyager data does not allow chaotic or nonchaotic rotation to be distinguished. New observations obtained with a higher sampling frequency are reported here which conclusively show that the 13.1 day period found by Thomas et al. was not due to coherent rotation.

  14. Controlling Chaotic Lasers

    NASA Technical Reports Server (NTRS)

    Gills, Zelda; Roy, Rajarshi

    1995-01-01

    Irregular fluctuations in intensity have long plagued the operation of a wide variety of solid-state lasers. We are exploring the possibility of exploiting rather than avoiding a laser's chaotic output. As an important step in that direction, we have applied a novel control technique to stabilize a solid state laser. By making small periodic changes in only one input parameter of the laser, we are able to stabilize complex periodic waveforms and steady state behavior in the laser output. We demonstrate the application of this approach in a diode pumped Nd:/YAG laser system.

  15. Learning, Exploration and Chaotic Policies

    NASA Astrophysics Data System (ADS)

    Potapov, Alexei B.; Ali, M. K.

    We consider different versions of exploration in reinforcement learning. For the test problem, we use navigation in a shortcut maze. It is shown that chaotic ɛ-greedy policy may be as efficient as a random one. The best results were obtained with a model chaotic neuron. Therefore, exploration strategy can be implemented in a deterministic learning system such as a neural network.

  16. Micro-fluidic interconnect

    DOEpatents

    Okandan, Murat; Galambos, Paul C.; Benavides, Gilbert L.; Hetherington, Dale L.

    2006-02-28

    An apparatus for simultaneously aligning and interconnecting microfluidic ports is presented. Such interconnections are required to utilize microfluidic devices fabricated in Micro-Electromechanical-Systems (MEMS) technologies, that have multiple fluidic access ports (e.g. 100 micron diameter) within a small footprint, (e.g. 3 mm.times.6 mm). Fanout of the small ports of a microfluidic device to a larger diameter (e.g. 500 microns) facilitates packaging and interconnection of the microfluidic device to printed wiring boards, electronics packages, fluidic manifolds etc.

  17. Microfluidics for manipulating cells.

    PubMed

    Mu, Xuan; Zheng, Wenfu; Sun, Jiashu; Zhang, Wei; Jiang, Xingyu

    2013-01-14

    Microfluidics, a toolbox comprising methods for precise manipulation of fluids at small length scales (micrometers to millimeters), has become useful for manipulating cells. Its uses range from dynamic management of cellular interactions to high-throughput screening of cells, and to precise analysis of chemical contents in single cells. Microfluidics demonstrates a completely new perspective and an excellent practical way to manipulate cells for solving various needs in biology and medicine. This review introduces and comments on recent achievements and challenges of using microfluidics to manipulate and analyze cells. It is believed that microfluidics will assume an even greater role in the mechanistic understanding of cell biology and, eventually, in clinical applications.

  18. The chaotic rotation of Hyperion

    NASA Technical Reports Server (NTRS)

    Wisdom, J.; Peale, S. J.; Mignard, F.

    1984-01-01

    Under the assumption that the satellite is rotating about a principal axis that is normal to its orbit plane, a plot of spin rate-versus-orientation for Hyperion at the pericenter of its orbit has revealed a large, chaotic zone surrounding Hyperion's synchronous spin-orbit state. The chaotic zone is so large that it surrounds the 1/2 and 2 states, and libration in the 3/2 state is not possible. Rotation in the chaotic zone is also attitude-unstable. As tidal dissipation drives Hyperion's spin toward a nearly synchronous value, Hyperion necessarily enters the large chaotic zone, becoming attitude-unstable and tumbling. It is therefore predicted that Hyperion will be found to be tumbling chaotically.

  19. Simple and cheap microfluidic devices for the preparation of monodisperse emulsions.

    PubMed

    Deng, Nan-Nan; Meng, Zhi-Jun; Xie, Rui; Ju, Xiao-Jie; Mou, Chuan-Lin; Wang, Wei; Chu, Liang-Ying

    2011-12-01

    Droplet microfluidics, which can generate monodisperse droplets or bubbles in unlimited numbers, at high speed and with complex structures, have been extensively investigated in chemical and biological fields. However, most current methods for fabricating microfluidic devices, such as glass etching, soft lithography in polydimethylsiloxane (PDMS) or assembly of glass capillaries, are usually either expensive or complicated. Here we report the fabrication of simple and cheap microfluidic devices based on patterned coverslips and microscope glass slides. The advantages of our approach for fabricating microfluidic devices lie in a simple process, inexpensive processing equipment and economical laboratory supplies. The fabricated microfluidic devices feature a flexible design of microchannels, easy spatial patterning of surface wettability, and good chemical compatibility and optical properties. We demonstrate their utilities for generation of monodisperse single and double emulsions with highly controllable flexibility. PMID:22025190

  20. Active pneumatic control of centrifugal microfluidic flows for lab-on-a-chip applications.

    PubMed

    Clime, Liviu; Brassard, Daniel; Geissler, Matthias; Veres, Teodor

    2015-06-01

    This paper reports a novel method of controlling liquid motion on a centrifugal microfluidic platform based on the integration of a regulated pressure pump and a programmable electromechanical valving system. We demonstrate accurate control over the displacement of liquids within the system by pressurizing simultaneously multiple ports of the microfluidic device while the platform is rotating at high speed. Compared to classical centrifugal microfluidic platforms where liquids are solely driven by centrifugal and capillary forces, the method presented herein adds a new degree of freedom for fluidic manipulation, which represents a paradigm change in centrifugal microfluidics. We first demonstrate how various core microfluidic functions such as valving, switching, and reverse pumping (i.e., against the centrifugal field) can be easily achieved by programming the pressures applied at dedicated access ports of the microfluidic device. We then show, for the first time, that the combination of centrifugal force and active pneumatic pumping offers the possibility of mixing fluids rapidly (~0.1 s) and efficiently based on the creation of air bubbles at the bottom of a microfluidic reservoir. Finally, the suitability of the developed platform for performing complex bioanalytical assays in an automated fashion is demonstrated in a DNA harvesting experiment where recovery rates of about 70% were systematically achieved. The proposed concept offers the interesting prospect to decouple basic microfluidic functions from specific material properties, channel dimensions and fabrication tolerances, surface treatments, or on-chip active components, thus promoting integration of complex assays on simple and low-cost microfluidic cartridges.

  1. Tribonucleation of bubbles.

    PubMed

    Wildeman, Sander; Lhuissier, Henri; Sun, Chao; Lohse, Detlef; Prosperetti, Andrea

    2014-07-15

    We report on the nucleation of bubbles on solids that are gently rubbed against each other in a liquid. The phenomenon is found to depend strongly on the material and roughness of the solid surfaces. For a given surface, temperature, and gas content, a trail of growing bubbles is observed if the rubbing force and velocity exceed a certain threshold. Direct observation through a transparent solid shows that each bubble in the trail results from the early coalescence of several microscopic bubbles, themselves detaching from microscopic gas pockets forming between the solids. From a detailed study of the wear tracks, with atomic force and scanning electron microscopy imaging, we conclude that these microscopic gas pockets originate from a local fracturing of the surface asperities, possibly enhanced by chemical reactions at the freshly created surfaces. Our findings will be useful either for preventing undesired bubble formation or, on the contrary, for "writing with bubbles," i.e., creating controlled patterns of microscopic bubbles.

  2. Probing Cell Deformability via Acoustically Actuated Bubbles.

    PubMed

    Xie, Yuliang; Nama, Nitesh; Li, Peng; Mao, Zhangming; Huang, Po-Hsun; Zhao, Chenglong; Costanzo, Francesco; Huang, Tony Jun

    2016-02-17

    An acoustically actuated, bubble-based technique is developed to investigate the deformability of cells suspended in microfluidic devices. A microsized bubble is generated by an optothermal effect near the targeted cells, which are suspended in a microfluidic chamber. Subsequently, acoustic actuation is employed to create localized acoustic streaming. In turn, the streaming flow results in hydrodynamic forces that deform the cells in situ. The deformability of the cells is indicative of their mechanical properties. The method in this study measures mechanical biomarkers from multiple cells in a single experiment, and it can be conveniently integrated with other bioanalysis and drug-screening platforms. Using this technique, the mean deformability of tens of HeLa, HEK, and HUVEC cells is measured to distinguish their mechanical properties. HeLa cells are deformed upon treatment with Cytochalasin. The technique also reveals the deformability of each subpopulation in a mixed, heterogeneous cell sample by the use of both fluorescent markers and mechanical biomarkers. The technique in this study, apart from being relevant to cell biology, will also enable biophysical cellular diagnosis. PMID:26715211

  3. Probing Cell Deformability via Acoustically Actuated Bubbles.

    PubMed

    Xie, Yuliang; Nama, Nitesh; Li, Peng; Mao, Zhangming; Huang, Po-Hsun; Zhao, Chenglong; Costanzo, Francesco; Huang, Tony Jun

    2016-02-17

    An acoustically actuated, bubble-based technique is developed to investigate the deformability of cells suspended in microfluidic devices. A microsized bubble is generated by an optothermal effect near the targeted cells, which are suspended in a microfluidic chamber. Subsequently, acoustic actuation is employed to create localized acoustic streaming. In turn, the streaming flow results in hydrodynamic forces that deform the cells in situ. The deformability of the cells is indicative of their mechanical properties. The method in this study measures mechanical biomarkers from multiple cells in a single experiment, and it can be conveniently integrated with other bioanalysis and drug-screening platforms. Using this technique, the mean deformability of tens of HeLa, HEK, and HUVEC cells is measured to distinguish their mechanical properties. HeLa cells are deformed upon treatment with Cytochalasin. The technique also reveals the deformability of each subpopulation in a mixed, heterogeneous cell sample by the use of both fluorescent markers and mechanical biomarkers. The technique in this study, apart from being relevant to cell biology, will also enable biophysical cellular diagnosis.

  4. Centrifugal microfluidic platforms: advanced unit operations and applications.

    PubMed

    Strohmeier, O; Keller, M; Schwemmer, F; Zehnle, S; Mark, D; von Stetten, F; Zengerle, R; Paust, N

    2015-10-01

    Centrifugal microfluidics has evolved into a mature technology. Several major diagnostic companies either have products on the market or are currently evaluating centrifugal microfluidics for product development. The fields of application are widespread and include clinical chemistry, immunodiagnostics and protein analysis, cell handling, molecular diagnostics, as well as food, water, and soil analysis. Nevertheless, new fluidic functions and applications that expand the possibilities of centrifugal microfluidics are being introduced at a high pace. In this review, we first present an up-to-date comprehensive overview of centrifugal microfluidic unit operations. Then, we introduce the term "process chain" to review how these unit operations can be combined for the automation of laboratory workflows. Such aggregation of basic functionalities enables efficient fluidic design at a higher level of integration. Furthermore, we analyze how novel, ground-breaking unit operations may foster the integration of more complex applications. Among these are the storage of pneumatic energy to realize complex switching sequences or to pump liquids radially inward, as well as the complete pre-storage and release of reagents. In this context, centrifugal microfluidics provides major advantages over other microfluidic actuation principles: the pulse-free inertial liquid propulsion provided by centrifugal microfluidics allows for closed fluidic systems that are free of any interfaces to external pumps. Processed volumes are easily scalable from nanoliters to milliliters. Volume forces can be adjusted by rotation and thus, even for very small volumes, surface forces may easily be overcome in the centrifugal gravity field which enables the efficient separation of nanoliter volumes from channels, chambers or sensor matrixes as well as the removal of any disturbing bubbles. In summary, centrifugal microfluidics takes advantage of a comprehensive set of fluidic unit operations such as

  5. Centrifugal microfluidic platforms: advanced unit operations and applications.

    PubMed

    Strohmeier, O; Keller, M; Schwemmer, F; Zehnle, S; Mark, D; von Stetten, F; Zengerle, R; Paust, N

    2015-10-01

    Centrifugal microfluidics has evolved into a mature technology. Several major diagnostic companies either have products on the market or are currently evaluating centrifugal microfluidics for product development. The fields of application are widespread and include clinical chemistry, immunodiagnostics and protein analysis, cell handling, molecular diagnostics, as well as food, water, and soil analysis. Nevertheless, new fluidic functions and applications that expand the possibilities of centrifugal microfluidics are being introduced at a high pace. In this review, we first present an up-to-date comprehensive overview of centrifugal microfluidic unit operations. Then, we introduce the term "process chain" to review how these unit operations can be combined for the automation of laboratory workflows. Such aggregation of basic functionalities enables efficient fluidic design at a higher level of integration. Furthermore, we analyze how novel, ground-breaking unit operations may foster the integration of more complex applications. Among these are the storage of pneumatic energy to realize complex switching sequences or to pump liquids radially inward, as well as the complete pre-storage and release of reagents. In this context, centrifugal microfluidics provides major advantages over other microfluidic actuation principles: the pulse-free inertial liquid propulsion provided by centrifugal microfluidics allows for closed fluidic systems that are free of any interfaces to external pumps. Processed volumes are easily scalable from nanoliters to milliliters. Volume forces can be adjusted by rotation and thus, even for very small volumes, surface forces may easily be overcome in the centrifugal gravity field which enables the efficient separation of nanoliter volumes from channels, chambers or sensor matrixes as well as the removal of any disturbing bubbles. In summary, centrifugal microfluidics takes advantage of a comprehensive set of fluidic unit operations such as

  6. Microfluidics in biotechnology

    PubMed Central

    Barry, Richard; Ivanov, Dimitri

    2004-01-01

    Microfluidics enables biotechnological processes to proceed on a scale (microns) at which physical processes such as osmotic movement, electrophoretic-motility and surface interactions become enhanced. At the microscale sample volumes and assay times are reduced, and procedural costs are lowered. The versatility of microfluidic devices allows interfacing with current methods and technologies. Microfluidics has been applied to DNA analysis methods and shown to accelerate DNA microarray assay hybridisation times. The linking of microfluidics to protein analysis techologies, e.g. mass spectrometry, enables picomole amounts of peptide to be analysed within a controlled micro-environment. The flexibility of microfluidics will facilitate its exploitation in assay development across multiple biotechnological disciplines. PMID:15056390

  7. Semiclassical theory of chaotic conductors.

    PubMed

    Heusler, Stefan; Müller, Sebastian; Braun, Petr; Haake, Fritz

    2006-02-17

    We calculate the Landauer conductance through chaotic ballistic devices in the semiclassical limit, to all orders in the inverse number of scattering channels without and with a magnetic field. Families of pairs of entrance-to-exit trajectories contribute, similarly to the pairs of periodic orbits making up the small-time expansion of the spectral form factor of chaotic dynamics. As a clue to the exact result we find that close self-encounters slightly hinder the escape of trajectories into leads. Our result explains why the energy-averaged conductance of individual chaotic cavities, with disorder or "clean," agrees with predictions of random-matrix theory. PMID:16606030

  8. Unconventional microfluidics: expanding the discipline

    PubMed Central

    Nawaz, Ahmad Ahsan; Mao, Xiaole; Stratton, Zackary S.; Huang, Tony Jun

    2014-01-01

    Since its inception, the discipline of microfluidics has been harnessed for innovations in the biomedicine/chemistry fields—and to great effect. This success has had the natural side-effect of stereotyping microfluidics as a platform for medical diagnostics and miniaturized lab processes. But microfluidics has more to offer. And very recently, some researchers have successfully applied microfluidics to fields outside its traditional domains. In this Focus article, we highlight notable examples of such “unconventional” microfluidics applications (e.g., robotics, electronics). It is our hope that these early successes in unconventional microfluidics prompt further creativity, and inspire readers to expand the microfluidics discipline. PMID:23478651

  9. Unconventional microfluidics: expanding the discipline.

    PubMed

    Nawaz, Ahmad Ahsan; Mao, Xiaole; Stratton, Zackary S; Huang, Tony Jun

    2013-04-21

    Since its inception, the discipline of microfluidics has been harnessed for innovations in the biomedicine/chemistry fields-and to great effect. This success has had the natural side-effect of stereotyping microfluidics as a platform for medical diagnostics and miniaturized lab processes. But microfluidics has more to offer. And very recently, some researchers have successfully applied microfluidics to fields outside its traditional domains. In this Focus article, we highlight notable examples of such "unconventional" microfluidics applications (e.g., robotics, electronics). It is our hope that these early successes in unconventional microfluidics prompt further creativity, and inspire readers to expand the microfluidics discipline.

  10. Chaotic and Arnold stripes in weakly chaotic Hamiltonian systems.

    PubMed

    Custódio, M S; Manchein, C; Beims, M W

    2012-06-01

    The dynamics in weakly chaotic Hamiltonian systems strongly depends on initial conditions (ICs) and little can be affirmed about generic behaviors. Using two distinct Hamiltonian systems, namely one particle in an open rectangular billiard and four particles globally coupled on a discrete lattice, we show that in these models, the transition from integrable motion to weak chaos emerges via chaotic stripes as the nonlinear parameter is increased. The stripes represent intervals of initial conditions which generate chaotic trajectories and increase with the nonlinear parameter of the system. In the billiard case, the initial conditions are the injection angles. For higher-dimensional systems and small nonlinearities, the chaotic stripes are the initial condition inside which Arnold diffusion occurs.

  11. Bubble gate for in-plane flow control.

    PubMed

    Oskooei, Ali; Abolhasani, Milad; Günther, Axel

    2013-07-01

    We introduce a miniature gate valve as a readily implementable strategy for actively controlling the flow of liquids on-chip, within a footprint of less than one square millimetre. Bubble gates provide for simple, consistent and scalable control of liquid flow in microchannel networks, are compatible with different bulk microfabrication processes and substrate materials, and require neither electrodes nor moving parts. A bubble gate consists of two microchannel sections: a liquid-filled channel and a gas channel that intercepts the liquid channel to form a T-junction. The open or closed state of a bubble gate is determined by selecting between two distinct gas pressure levels: the lower level corresponds to the "open" state while the higher level corresponds to the "closed" state. During closure, a gas bubble penetrates from the gas channel into the liquid, flanked by a column of equidistantly spaced micropillars on each side, until the flow of liquid is completely obstructed. We fabricated bubble gates using single-layer soft lithographic and bulk silicon micromachining procedures and evaluated their performance with a combination of theory and experimentation. We assessed the dynamic behaviour during more than 300 open-and-close cycles and report the operating pressure envelope for different bubble gate configurations and for the working fluids: de-ionized water, ethanol and a biological buffer. We obtained excellent agreement between the experimentally determined bubble gate operational envelope and a theoretical prediction based on static wetting behaviour. We report case studies that serve to illustrate the utility of bubble gates for liquid sampling in single and multi-layer microfluidic devices. Scalability of our strategy was demonstrated by simultaneously addressing 128 bubble gates.

  12. Sheathless hydrodynamic positioning of buoyant drops and bubbles inside microchannels.

    PubMed

    Stan, Claudiu A; Guglielmini, Laura; Ellerbee, Audrey K; Caviezel, Daniel; Stone, Howard A; Whitesides, George M

    2011-09-01

    Particles, bubbles, and drops carried by a fluid in a confined environment such as a pipe can be subjected to hydrodynamic lift forces, i.e., forces that are perpendicular to the direction of the flow. We investigated the positioning effect of lift forces acting on buoyant drops and bubbles suspended in a carrier fluid and flowing in a horizontal microchannel. We report experiments on drops of water in fluorocarbon liquid, and on bubbles of nitrogen in hydrocarbon liquid and silicone oil, inside microchannels with widths on the order of 0.1-1 mm. Despite their buoyancy, drops and bubbles could travel without contacting with the walls of channels; the most important parameters for reaching this flow regime in our experiments were the viscosity and the velocity of the carrier fluid, and the sizes of drops and bubbles. The dependencies of the transverse position of drops and bubbles on these parameters were investigated. At steady state, the trajectories of drops and bubbles approached the center of the channel for drops and bubbles almost as large as the channel, carried by rapidly flowing viscous liquids; among our experiments, these flow conditions were characterized by larger capillary numbers and smaller Reynolds numbers. Analytical models of lift forces developed for the flow of drops much smaller than the width of the channel failed to predict their transverse position, while computational fluid dynamic simulations of the experiments agreed better with the experimental measurements. The degrees of success of these predictions indicate the importance of confinement on generating strong hydrodynamic lift forces. We conclude that, inside microfluidic channels, it is possible to support and position buoyant drops and bubbles simply by flowing a single-stream (i.e., "sheathless") carrier liquid that has appropriate velocity and hydrodynamic properties.

  13. Gas bubble detector

    NASA Technical Reports Server (NTRS)

    Mount, Bruce E. (Inventor); Burchfield, David E. (Inventor); Hagey, John M. (Inventor)

    1995-01-01

    A gas bubble detector having a modulated IR source focused through a bandpass filter onto a venturi, formed in a sample tube, to illuminate the venturi with modulated filtered IR to detect the presence of gas bubbles as small as 0.01 cm or about 0.004 in diameter in liquid flowing through the venturi. Means are provided to determine the size of any detected bubble and to provide an alarm in the absence of liquid in the sample tube.

  14. Electronic Realization Of Chaotic Systems

    NASA Astrophysics Data System (ADS)

    Parker, Christopher; Leiseth, Jeffrey; Braunstein, Michael; Rosell, Sharon; Petersen, Travis; Masters, Evan; Kangas, Eric

    2008-05-01

    The CWU chapter of the SPS is investigating electronic realizations of chaotic systems. Understanding the fundamental principles that govern this behavior is sought not only for its inherent educational value, but for its applications in physics, information theory, meteorology, biology and mathematics. J.C. Sprott has reported on a class of chaotic differential equations that can, in principle, be simply realized using discrete electronic components. These circuits can be used to investigate chaotic behavior in a simple system. We will present computational and experimental data collected from one simple chaotic circuit. Our computational results include eigenvalues and eigenvectors of the Jacobian, return maps, largest Lyapunov exponents and the numerical approximation of solutions to the differential equation utilized. Our data include output voltages at different points in the circuit representing the phase space behavior of the system. A comparison between the model and collected experimental data will be provided to analyze the realization of the nonlinear differential equation.

  15. Stem cells in microfluidics

    PubMed Central

    Wu, Huei-Wen; Lin, Chun-Che; Lee, Gwo-Bin

    2011-01-01

    Microfluidic techniques have been recently developed for cell-based assays. In microfluidic systems, the objective is for these microenvironments to mimic in vivo surroundings. With advantageous characteristics such as optical transparency and the capability for automating protocols, different types of cells can be cultured, screened, and monitored in real time to systematically investigate their morphology and functions under well-controlled microenvironments in response to various stimuli. Recently, the study of stem cells using microfluidic platforms has attracted considerable interest. Even though stem cells have been studied extensively using bench-top systems, an understanding of their behavior in in vivo-like microenvironments which stimulate cell proliferation and differentiation is still lacking. In this paper, recent cell studies using microfluidic systems are first introduced. The various miniature systems for cell culture, sorting and isolation, and stimulation are then systematically reviewed. The main focus of this review is on papers published in recent years studying stem cells by using microfluidic technology. This review aims to provide experts in microfluidics an overview of various microfluidic systems for stem cell research. PMID:21522491

  16. Microfluidics and microbial engineering.

    PubMed

    Kou, Songzi; Cheng, Danhui; Sun, Fei; Hsing, I-Ming

    2016-02-01

    The combination of microbial engineering and microfluidics is synergistic in nature. For example, microfluidics is benefiting from the outcome of microbial engineering and many reported point-of-care microfluidic devices employ engineered microbes as functional parts for the microsystems. In addition, microbial engineering is facilitated by various microfluidic techniques, due to their inherent strength in high-throughput screening and miniaturization. In this review article, we firstly examine the applications of engineered microbes for toxicity detection, biosensing, and motion generation in microfluidic platforms. Secondly, we look into how microfluidic technologies facilitate the upstream and downstream processes of microbial engineering, including DNA recombination, transformation, target microbe selection, mutant characterization, and microbial function analysis. Thirdly, we highlight an emerging concept in microbial engineering, namely, microbial consortium engineering, where the behavior of a multicultural microbial community rather than that of a single cell/species is delineated. Integrating the disciplines of microfluidics and microbial engineering opens up many new opportunities, for example in diagnostics, engineering of microbial motors, development of portable devices for genetics, high throughput characterization of genetic mutants, isolation and identification of rare/unculturable microbial species, single-cell analysis with high spatio-temporal resolution, and exploration of natural microbial communities.

  17. Cryptosystems based on chaotic dynamics

    SciTech Connect

    McNees, R.A.; Protopopescu, V.; Santoro, R.T.; Tolliver, J.S.

    1993-08-01

    An encryption scheme based on chaotic dynamics is presented. This scheme makes use of the efficient and reproducible generation of cryptographically secure pseudo random numbers from chaotic maps. The result is a system which encrypts quickly and possesses a large keyspace, even in small precision implementations. This system offers an excellent solution to several problems including the dissemination of key material, over the air rekeying, and other situations requiring the secure management of information.

  18. Nanomaterials meet microfluidics.

    PubMed

    Pumera, Martin

    2011-05-28

    Nanomaterials and lab-on-a-chip platforms have undergone enormous development during the past decade. Here, we present an overview of how microfluidics benefited from the use of nanomaterials for the enhanced separation and detection of analytes. We also discuss how nanomaterials benefit from microfluidics in terms of synthesis and in terms of the simulation of environments for nanomotors and nanorobots. In our opinion, the "marriage" of nanomaterials and microfluidics is highly beneficial and is expected to solve vital challenges in related fields.

  19. Prospects for bubble fusion

    SciTech Connect

    Nigmatulin, R.I.; Lahey, R.T. Jr.

    1995-09-01

    In this paper a new method for the realization of fusion energy is presented. This method is based on the superhigh compression of a gas bubble (deuterium or deuterium/thritium) in heavy water or another liquid. The superhigh compression of a gas bubble in a liquid is achieved through forced non-linear, non-periodic resonance oscillations using moderate amplitudes of forcing pressure. The key feature of this new method is a coordination of the forced liquid pressure change with the change of bubble volume. The corresponding regime of the bubble oscillation has been called {open_quotes}basketball dribbling (BD) regime{close_quotes}. The analytical solution describing this process for spherically symmetric bubble oscillations, neglecting dissipation and compressibility of the liquid, has been obtained. This solution shown no limitation on the supercompression of the bubble and the corresponding maximum temperature. The various dissipation mechanisms, including viscous, conductive and radiation heat losses have been considered. It is shown that in spite of these losses it is possible to achieve very high gas bubble temperatures. This because the time duration of the gas bubble supercompression becomes very short when increasing the intensity of compression, thus limiting the energy losses. Significantly, the calculated maximum gas temperatures have shown that nuclear fusion may be possible. First estimations of the affect of liquid compressibility have been made to determine possible limitations on gas bubble compression. The next step will be to investigate the role of interfacial instability and breaking down of the bubble, shock wave phenomena around and in the bubble and mutual diffusion of the gas and the liquid.

  20. Adjustable, rapidly switching microfluidic gradient generation using focused travelling surface acoustic waves

    SciTech Connect

    Destgeer, Ghulam; Im, Sunghyuk; Hang Ha, Byung; Ho Jung, Jin; Ahmad Ansari, Mubashshir; Jin Sung, Hyung

    2014-01-13

    We demonstrate a simple device to generate chemical concentration gradients in a microfluidic channel using focused travelling surface acoustic waves (F-TSAW). A pair of curved interdigitated metal electrodes deposited on the surface of a piezoelectric (LiNbO{sub 3}) substrate disseminate high frequency sound waves when actuated by an alternating current source. The F-TSAW produces chaotic acoustic streaming flow upon its interaction with the fluid inside a microfluidic channel, which mixes confluent streams of chemicals in a controlled fashion for an adjustable and rapidly switching gradient generation.

  1. Dimension of chaotic attractors

    SciTech Connect

    Farmer, J.D.; Ott, E.; Yorke, J.A.

    1982-09-01

    Dimension is perhaps the most basic property of an attractor. In this paper we discuss a variety of different definitions of dimension, compute their values for a typical example, and review previous work on the dimension of chaotic attractors. The relevant definitions of dimension are of two general types, those that depend only on metric properties, and those that depend on probabilistic properties (that is, they depend on the frequency with which a typical trajectory visits different regions of the attractor). Both our example and the previous work that we review support the conclusion that all of the probabilistic dimensions take on the same value, which we call the dimension of the natural measure, and all of the metric dimensions take on a common value, which we call the fractal dimension. Furthermore, the dimension of the natural measure is typically equal to the Lyapunov dimension, which is defined in terms of Lyapunov numbers, and thus is usually far easier to calculate than any other definition. Because it is computable and more physically relevant, we feel that the dimension of the natural measure is more important than the fractal dimension.

  2. Chaotic Rotation of Nereid

    NASA Technical Reports Server (NTRS)

    Dobrovolskis, Anthony R.; Cuzzi, Jeffrey N. (Technical Monitor)

    1995-01-01

    The shape and spin of Neptune's outermost satellite Nereid are still unknown. Ground-based photometry indicates large brightness variations, but different observers report very different lightcurve amplitudes and periods. On the contrary, Voyager 2 images spanning 12 days show no evidence of variations greater than 0.1 mag. The latter suggest either that Nereid is nearly spherical, or that it is rotating slowly. We propose that tides have already despun Nereid's rotation to a period of a few weeks, during the time before the capture of Triton when Nereid was closer to Neptune. Since Nereid reached its present orbit, tides have further despun Nereid to a period on the order of a month. For Nereid's orbital eccentricity of 0.75, tidal evolution ceases when the spin period is still approximately 1/8 of the orbital period. Furthermore, the synchronous resonance becomes quite weak for such high eccentricities, along with other low-order spin orbit commensurabilities. In contrast, high-order resonances become very strong particularly the 6:1, 6.5:1, 7:1, 7.5:1, and 8:1 spin states. If Nereid departs by more than approximately 1% from a sphere, however, these resonances overlap, generating chaos. Our simulations show that Nereid is likely to be in chaotic rotation for any spin period longer than about 2 weeks.

  3. Chaotic Neocortical Dynamics

    NASA Astrophysics Data System (ADS)

    Freeman, Walter J.

    2013-01-01

    The first step of the sensory systems is to construct the meaning of the information they receive from the senses. They do this by generating random noise and then filtering the noise with adaptive filters. We simulate the operation with the solutions of matrices of ordinary differential equations that predict subcritical Hopf bifurcations between point and limit cycle attractors. The second step is integration of the outputs from the several sensory systems into a multisensory percept, called a gestalt, which in the third step is consolidated and stored as knowledge. Simulation of the second step requires use of landscapes of nonconvergent chaotic attractors. This is not deterministic chaos, which is much too brittle owing to the infinite sensitivity to initial conditions. It is a hybrid form we call stochastic chaos, which is stabilized by additive noise modeled on noise sources in the sensory systems. Thus bifurcation and chaos theory provides tools for succinct empirical models of cortical dynamics performing the most basic cognitive operations: generalization, abstraction, and categorization in constructing knowledge. The descriptions are in a form that is suitable for more advanced modeling using analog VLSI, neuropercolation from random graph theory, non-equilibrium dissipative thermodynamics, and macroscopic many-body physics. This review concludes with a summary of the applications of stochastic chaos in pattern classification and some prescriptions for neurobiologists on what to look for in large-scale anatomical formations.

  4. There can be turbulence in microfluidics at low Reynolds number.

    PubMed

    Wang, G R; Yang, Fang; Zhao, Wei

    2014-04-21

    Turbulence is commonly viewed as a type of macroflow, where the Reynolds number (Re) has to be sufficiently high. In microfluidics, when Re is below or on the order of 1 and fast mixing is required, so far only chaotic flow has been reported to enhance mixing based on previous publications since turbulence is believed not to be possible to generate in such a low Re microflow. There is even a lack of velocimeter that can measure turbulence in microchannels. In this work, we report a direct observation of the existence of turbulence in microfluidics with Re on the order of 1 in a pressure driven flow under electrokinetic forcing using a novel velocimeter having ultrahigh spatiotemporal resolution. The work could provide a new method to control flow and transport phenomena in lab-on-a-chip and a new perspective on turbulence.

  5. Gases in Tektite Bubbles.

    PubMed

    O'keefe, J A; Lowman, P D; Dunning, K L

    1962-07-20

    Spectroscopic analysis of light produced by electrodeless discharge in a tektite bubble showed the main gases in the bubble to be neon, helium, and oxygen. The neon and helium have probably diffused in from the atmosphere, while the oxygen may be atmospheric gas incorporated in the tektite during its formation.

  6. Always Blowing Bubbles.

    ERIC Educational Resources Information Center

    Grambo, Gregory

    1995-01-01

    Ways to explore blowing bubbles through observation, experimentation, and discovery are suggested to stimulate gifted children, with attention to such areas as the function of film in the liquid and the reason for the common spherical shape of bubbles. Experiments that children can try and tips for the teacher are presented. (SW)

  7. Clustering in bubbly liquids

    NASA Astrophysics Data System (ADS)

    Figueroa, Bernardo; Zenit, Roberto

    2004-11-01

    We are conducting experiments to determine the amount of clustering that occurs when small gas bubbles ascend in clean water. In particular, we are interested in flows for which the liquid motion around the bubbles can be described, with a certain degree of accuracy, using potential flow theory. This model is applicable for the case of bubbly liquids in which the Reynolds number is large and the Weber number is small. To clearly observe the formation of bubble clusters we propose the use of a Hele-Shaw-type channel. In this thin channel the bubbles cannot overlap in the depth direction, therefore the identification of bubble clusters cannot be misinterpreted. Direct video image analysis is performed to calculate the velocity and size of the bubbles, as well as the formation of clusters. Although the walls do affect the motion of the bubbles, the clustering phenomena does occur and has the same qualitative behavior as in fully three-dimensional flows. A series of preliminary measurements are presented. A brief discussion of our plans to perform PIV measurements to obtain the liquid velocity fields is also presented.

  8. Cost versus Enrollment Bubbles

    ERIC Educational Resources Information Center

    Vedder, Richard K.; Gillen, Andrew

    2011-01-01

    The defining characteristic of a bubble is unsustainable growth that eventually reverses. Bubbles typically arise when uncertainty leads to unsustainable trends, and the authors argue that there are two areas in which higher education has experienced what appear to be unsustainable trends, namely, college costs (the costs to students, parents, and…

  9. Let Them Blow Bubbles.

    ERIC Educational Resources Information Center

    Korenic, Eileen

    1988-01-01

    Describes a series of activities and demonstrations involving the science of soap bubbles. Starts with a recipe for bubble solution and gives instructions for several activities on topics such as density, interference colors, optics, static electricity, and galaxy formation. Contains some background information to help explain some of the effects.…

  10. Gases in Tektite Bubbles.

    PubMed

    O'keefe, J A; Lowman, P D; Dunning, K L

    1962-07-20

    Spectroscopic analysis of light produced by electrodeless discharge in a tektite bubble showed the main gases in the bubble to be neon, helium, and oxygen. The neon and helium have probably diffused in from the atmosphere, while the oxygen may be atmospheric gas incorporated in the tektite during its formation. PMID:17801113

  11. Evaporation, Boiling and Bubbles

    ERIC Educational Resources Information Center

    Goodwin, Alan

    2012-01-01

    Evaporation and boiling are both terms applied to the change of a liquid to the vapour/gaseous state. This article argues that it is the formation of bubbles of vapour within the liquid that most clearly differentiates boiling from evaporation although only a minority of chemistry textbooks seems to mention bubble formation in this context. The…

  12. Microfluidics: reframing biological enquiry.

    PubMed

    Duncombe, Todd A; Tentori, Augusto M; Herr, Amy E

    2015-09-01

    The underlying physical properties of microfluidic tools have led to new biological insights through the development of microsystems that can manipulate, mimic and measure biology at a resolution that has not been possible with macroscale tools. Microsystems readily handle sub-microlitre volumes, precisely route predictable laminar fluid flows and match both perturbations and measurements to the length scales and timescales of biological systems. The advent of fabrication techniques that do not require highly specialized engineering facilities is fuelling the broad dissemination of microfluidic systems and their adaptation to specific biological questions. We describe how our understanding of molecular and cell biology is being and will continue to be advanced by precision microfluidic approaches and posit that microfluidic tools - in conjunction with advanced imaging, bioinformatics and molecular biology approaches - will transform biology into a precision science.

  13. Microfluidic chemical reaction circuits

    DOEpatents

    Lee, Chung-cheng; Sui, Guodong; Elizarov, Arkadij; Kolb, Hartmuth C.; Huang, Jiang; Heath, James R.; Phelps, Michael E.; Quake, Stephen R.; Tseng, Hsian-rong; Wyatt, Paul; Daridon, Antoine

    2012-06-26

    New microfluidic devices, useful for carrying out chemical reactions, are provided. The devices are adapted for on-chip solvent exchange, chemical processes requiring multiple chemical reactions, and rapid concentration of reagents.

  14. Cell manipulation in microfluidics.

    PubMed

    Yun, Hoyoung; Kim, Kisoo; Lee, Won Gu

    2013-06-01

    Recent advances in the lab-on-a-chip field in association with nano/microfluidics have been made for new applications and functionalities to the fields of molecular biology, genetic analysis and proteomics, enabling the expansion of the cell biology field. Specifically, microfluidics has provided promising tools for enhancing cell biological research, since it has the ability to precisely control the cellular environment, to easily mimic heterogeneous cellular environment by multiplexing, and to analyze sub-cellular information by high-contents screening assays at the single-cell level. Various cell manipulation techniques in microfluidics have been developed in accordance with specific objectives and applications. In this review, we examine the latest achievements of cell manipulation techniques in microfluidics by categorizing externally applied forces for manipulation: (i) optical, (ii) magnetic, (iii) electrical, (iv) mechanical and (v) other manipulations. We furthermore focus on history where the manipulation techniques originate and also discuss future perspectives with key examples where available.

  15. Examination of laser microbeam cell lysis in a PDMS microfluidic channel using time-resolved imaging.

    PubMed

    Quinto-Su, Pedro A; Lai, Hsuan-Hong; Yoon, Helen H; Sims, Christopher E; Allbritton, Nancy L; Venugopalan, Vasan

    2008-03-01

    We use time-resolved imaging to examine the lysis dynamics of non-adherent BAF-3 cells within a microfluidic channel produced by the delivery of single highly-focused 540 ps duration laser pulses at lambda = 532 nm. Time-resolved bright-field images reveal that the delivery of the pulsed laser microbeam results in the formation of a laser-induced plasma followed by shock wave emission and cavitation bubble formation. The confinement offered by the microfluidic channel constrains substantially the cavitation bubble expansion and results in significant deformation of the PDMS channel walls. To examine the cell lysis and dispersal of the cellular contents, we acquire time-resolved fluorescence images of the process in which the cells were loaded with a fluorescent dye. These fluorescence images reveal cell lysis to occur on the nanosecond to microsecond time scale by the plasma formation and cavitation bubble dynamics. Moreover, the time-resolved fluorescence images show that while the cellular contents are dispersed by the expansion of the laser-induced cavitation bubble, the flow associated with the bubble collapse subsequently re-localizes the cellular contents to a small region. This capacity of pulsed laser microbeam irradiation to achieve rapid cell lysis in microfluidic channels with minimal dilution of the cellular contents has important implications for their use in lab-on-a-chip applications. PMID:18305858

  16. Foundations of chaotic mixing.

    PubMed

    Wiggins, Stephen; Ottino, Julio M

    2004-05-15

    The simplest mixing problem corresponds to the mixing of a fluid with itself; this case provides a foundation on which the subject rests. The objective here is to study mixing independently of the mechanisms used to create the motion and review elements of theory focusing mostly on mathematical foundations and minimal models. The flows under consideration will be of two types: two-dimensional (2D) 'blinking flows', or three-dimensional (3D) duct flows. Given that mixing in continuous 3D duct flows depends critically on cross-sectional mixing, and that many microfluidic applications involve continuous flows, we focus on the essential aspects of mixing in 2D flows, as they provide a foundation from which to base our understanding of more complex cases. The baker's transformation is taken as the centrepiece for describing the dynamical systems framework. In particular, a hierarchy of characterizations of mixing exist, Bernoulli --> mixing --> ergodic, ordered according to the quality of mixing (the strongest first). Most importantly for the design process, we show how the so-called linked twist maps function as a minimal picture of mixing, provide a mathematical structure for understanding the type of 2D flows that arise in many micromixers already built, and give conditions guaranteeing the best quality mixing. Extensions of these concepts lead to first-principle-based designs without resorting to lengthy computations.

  17. Studies in Chaotic adiabatic dynamics

    SciTech Connect

    Jarzynski, C.

    1994-01-01

    Chaotic adiabatic dynamics refers to the study of systems exhibiting chaotic evolution under slowly time-dependent equations of motion. In this dissertation the author restricts his attention to Hamiltonian chaotic adiabatic systems. The results presented are organized around a central theme, namely, that the energies of such systems evolve diffusively. He begins with a general analysis, in which he motivates and derives a Fokker-Planck equation governing this process of energy diffusion. He applies this equation to study the {open_quotes}goodness{close_quotes} of an adiabatic invariant associated with chaotic motion. This formalism is then applied to two specific examples. The first is that of a gas of noninteracting point particles inside a hard container that deforms slowly with time. Both the two- and three-dimensional cases are considered. The results are discussed in the context of the Wall Formula for one-body dissipation in nuclear physics, and it is shown that such a gas approaches, asymptotically with time, an exponential velocity distribution. The second example involves the Fermi mechanism for the acceleration of cosmic rays. Explicit evolution equations are obtained for the distribution of cosmic ray energies within this model, and the steady-state energy distribution that arises when this equation is modified to account for the injection and removal of cosmic rays is discussed. Finally, the author re-examines the multiple-time-scale approach as applied to the study of phase space evolution under a chaotic adiabatic Hamiltonian. This leads to a more rigorous derivation of the above-mentioned Fokker-Planck equation, and also to a new term which has relevance to the problem of chaotic adiabatic reaction forces (the forces acting on slow, heavy degrees of freedom due to their coupling to light, fast chaotic degrees).

  18. Mass-transfer enhancement via chaotic laminar flow within a droplet

    NASA Astrophysics Data System (ADS)

    Bryden, Michelle D.; Brenner, Howard

    1999-01-01

    The Stokes flow occurring within a non-neutrally buoyant spherical droplet translating by buoyancy through an immiscible liquid which is undergoing simple shear is shown to be chaotic under many circumstances for which the droplet translates by buoyancy through the entraining fluid. This flow is easily produced, for example, when the droplet rises (or falls) through the annular space of a vertical concentric-cylinder Couette viscometer or through a vertical Poiseuille flow. The parameters studied include: (i) droplet/bulk fluid viscosity ratio; (ii) shear strength/bubble rise velocity ratio; and (iii) the angle between the translational bubble velocity vector and the vorticity vector characterizing the undisturbed shear. Streamlines existing within a droplet that translates perpendicular to this vorticity vector are shown to be non-chaotic for all choices of physical parameters. Other relative orientations frequently contain chaotic trajectories. When solute initially dissolved within the droplet is extracted into the bulk fluid, the resulting overall mass-transfer coefficient (calculated via generalized Taylor dispersion theory) quantifying the extraction rate at asymptotically long times is shown to be significantly higher in the chaotic flow case.

  19. Bubble collision with gravitation

    SciTech Connect

    Hwang, Dong-il; Lee, Bum-Hoon; Lee, Wonwoo; Yeom, Dong-han E-mail: bhl@sogang.ac.kr E-mail: innocent.yeom@gmail.com

    2012-07-01

    In this paper, we study vacuum bubble collisions with various potentials including gravitation, assuming spherical, planar, and hyperbolic symmetry. We use numerical calculations from double-null formalism. Spherical symmetry can mimic the formation of a black hole via multiple bubble collisions. Planar and especially hyperbolic symmetry describes two bubble collisions. We study both cases, when two true vacuum regions have the same field value or different field values, by varying tensions. For the latter case, we also test symmetric and asymmetric bubble collisions, and see details of causal structures. If the colliding energy is sufficient, then the vacuum can be destabilized, and it is also demonstrated. This double-null formalism can be a complementary approach in the context of bubble collisions.

  20. Interfacial Bubble Deformations

    NASA Astrophysics Data System (ADS)

    Seymour, Brian; Shabane, Parvis; Cypull, Olivia; Cheng, Shengfeng; Feitosa, Klebert

    Soap bubbles floating at an air-water experience deformations as a result of surface tension and hydrostatic forces. In this experiment, we investigate the nature of such deformations by taking cross-sectional images of bubbles of different volumes. The results show that as their volume increases, bubbles transition from spherical to hemispherical shape. The deformation of the interface also changes with bubble volume with the capillary rise converging to the capillary length as volume increases. The profile of the top and bottom of the bubble and the capillary rise are completely determined by the volume and pressure differences. James Madison University Department of Physics and Astronomy, 4VA Consortium, Research Corporation for Advancement of Science.

  1. Microfluidic fuel cells

    NASA Astrophysics Data System (ADS)

    Kjeang, Erik

    Microfluidic fuel cell architectures are presented in this thesis. This work represents the mechanical and microfluidic portion of a microfluidic biofuel cell project. While the microfluidic fuel cells developed here are targeted to eventual integration with biocatalysts, the contributions of this thesis have more general applicability. The cell architectures are developed and evaluated based on conventional non-biological electrocatalysts. The fuel cells employ co-laminar flow of fuel and oxidant streams that do not require a membrane for physical separation, and comprise carbon or gold electrodes compatible with most enzyme immobilization schemes developed to date. The demonstrated microfluidic fuel cell architectures include the following: a single cell with planar gold electrodes and a grooved channel architecture that accommodates gaseous product evolution while preventing crossover effects; a single cell with planar carbon electrodes based on graphite rods; a three-dimensional hexagonal array cell based on multiple graphite rod electrodes with unique scale-up opportunities; a single cell with porous carbon electrodes that provides enhanced power output mainly attributed to the increased active area; a single cell with flow-through porous carbon electrodes that provides improved performance and overall energy conversion efficiency; and a single cell with flow-through porous gold electrodes with similar capabilities and reduced ohmic resistance. As compared to previous results, the microfluidic fuel cells developed in this work show improved fuel cell performance (both in terms of power density and efficiency). In addition, this dissertation includes the development of an integrated electrochemical velocimetry approach for microfluidic devices, and a computational modeling study of strategic enzyme patterning for microfluidic biofuel cells with consecutive reactions.

  2. Electro-Microfluidic Packaging

    SciTech Connect

    BENAVIDES, GILBERT L.; GALAMBOS, PAUL C.

    2002-06-01

    Electro-microfluidics is experiencing explosive growth in new product developments. There are many commercial applications for electro-microfluidic devices such as chemical sensors, biological sensors, and drop ejectors for both printing and chemical analysis. The number of silicon surface micromachined electro-microfluidic products is likely to increase. Manufacturing efficiency and integration of microfluidics with electronics will become important. Surface micromachined microfluidic devices are manufactured with the same tools as IC's (integrated circuits) and their fabrication can be incorporated into the IC fabrication process. In order to realize applications for devices must be developed. An Electro-Microfluidic Dual In-line Package (EMDIP{trademark}) was developed surface micromachined electro-microfluidic devices, a practical method for getting fluid into these to be a standard solution that allows for both the electrical and the fluidic connections needed to operate a great variety of electro-microfluidic devices. The EMDIP{trademark} includes a fan-out manifold that, on one side, mates directly with the 200 micron diameter Bosch etched holes found on the device, and, on the other side, mates to lager 1 mm diameter holes. To minimize cost the EMDIP{trademark} can be injection molded in a great variety of thermoplastics which also serve to optimize fluid compatibility. The EMDIP{trademark} plugs directly into a fluidic printed wiring board using a standard dual in-line package pattern for the electrical connections and having a grid of multiple 1 mm diameter fluidic connections to mate to the underside of the EMDIP{trademark}.

  3. Flock-based microfluidics.

    PubMed

    Hitzbleck, Martina; Lovchik, Robert D; Delamarche, Emmanuel

    2013-05-21

    Flock-based microfluidics are created by depositing hydrophilic microfibers on an adhesive-coated substrate using an electric field. This enables the fabrication of self-powered microfluidics from one or more different kinds of fibers that form 2D and 3D flowpaths, which can wick 40 microliters of liquid per square centimeter. With this approach, large areas of functional wicking materials can be produced at extremely low cost.

  4. Microfluidic Mixing Technology for a Universal Health Sensor

    NASA Technical Reports Server (NTRS)

    Chan, Eugene Y.; Bae, Candice

    2009-01-01

    A highly efficient means of microfluidic mixing has been created for use with the rHEALTH sensor an elliptical mixer and passive curvilinear mixing patterns. The rHEALTH sensor provides rapid, handheld, complete blood count, cell differential counts, electrolyte measurements, and other lab tests based on a reusable, flow-based microfluidic platform. These geometries allow for cleaning in a reusable manner, and also allow for complete mixing of fluid streams. The microfluidic mixing is performed by flowing two streams of fluid into an elliptical or curvilinear design that allows the combination of the flows into one channel. The mixing is accomplished by either chaotic advection around micro - fluidic loops. All components of the microfluidic chip are flow-through, meaning that cleaning solution can be introduced into the chip to flush out cells, plasma proteins, and dye. Tests were performed on multiple chip geometries to show that cleaning is efficient in any flowthrough design. The conclusion from these experiments is that the chip can indeed be flushed out with microliter volumes of solution and biological samples are cleaned readily from the chip with minimal effort. The technology can be applied in real-time health monitoring at patient s bedside or in a doctor s office, and real-time clinical intervention in acute situations. It also can be used for daily measurement of hematocrit for patients on anticoagulant drugs, or to detect acute myocardial damage outside a hospital.

  5. Surface acoustic wave microfluidics

    PubMed Central

    Ding, Xiaoyun; Li, Peng; Lin, Sz-Chin Steven; Stratton, Zackary S.; Nama, Nitesh; Guo, Feng; Slotcavage, Daniel; Mao, Xiaole; Shi, Jinjie; Costanzo, Francesco; Huang, Tony Jun

    2014-01-01

    The recent introduction of surface acoustic wave (SAW) technology onto lab-on-a-chip platforms has opened a new frontier in microfluidics. The advantages provided by such SAW microfluidics are numerous: simple fabrication, high biocompatibility, fast fluid actuation, versatility, compact and inexpensive devices and accessories, contact-free particle manipulation, and compatibility with other microfluidic components. We believe that these advantages enable SAW microfluidics to play a significant role in a variety of applications in biology, chemistry, engineering, and medicine. In this review article, we discuss the theory underpinning SAWs and their interactions with particles and the contacting fluids in which they are suspended. We then review the SAW-enabled microfluidic devices demonstrated to date, starting with devices that accomplish fluid mixing and transport through the use of travelling SAW; we follow that by reviewing the more recent innovations achieved with standing SAW that enable such actions as particle/cell focusing, sorting, and patterning. Finally, we look forward and appraise where the discipline of SAW microfluidics could go next. PMID:23900527

  6. Surface acoustic wave microfluidics.

    PubMed

    Ding, Xiaoyun; Li, Peng; Lin, Sz-Chin Steven; Stratton, Zackary S; Nama, Nitesh; Guo, Feng; Slotcavage, Daniel; Mao, Xiaole; Shi, Jinjie; Costanzo, Francesco; Huang, Tony Jun

    2013-09-21

    The recent introduction of surface acoustic wave (SAW) technology onto lab-on-a-chip platforms has opened a new frontier in microfluidics. The advantages provided by such SAW microfluidics are numerous: simple fabrication, high biocompatibility, fast fluid actuation, versatility, compact and inexpensive devices and accessories, contact-free particle manipulation, and compatibility with other microfluidic components. We believe that these advantages enable SAW microfluidics to play a significant role in a variety of applications in biology, chemistry, engineering and medicine. In this review article, we discuss the theory underpinning SAWs and their interactions with particles and the contacting fluids in which they are suspended. We then review the SAW-enabled microfluidic devices demonstrated to date, starting with devices that accomplish fluid mixing and transport through the use of travelling SAW; we follow that by reviewing the more recent innovations achieved with standing SAW that enable such actions as particle/cell focusing, sorting and patterning. Finally, we look forward and appraise where the discipline of SAW microfluidics could go next.

  7. MEMS in microfluidic channels.

    SciTech Connect

    Ashby, Carol Iris Hill; Okandan, Murat; Michalske, Terry A.; Sounart, Thomas L.; Matzke, Carolyn M.

    2004-03-01

    Microelectromechanical systems (MEMS) comprise a new class of devices that include various forms of sensors and actuators. Recent studies have shown that microscale cantilever structures are able to detect a wide range of chemicals, biomolecules or even single bacterial cells. In this approach, cantilever deflection replaces optical fluorescence detection thereby eliminating complex chemical tagging steps that are difficult to achieve with chip-based architectures. A key challenge to utilizing this new detection scheme is the incorporation of functionalized MEMS structures within complex microfluidic channel architectures. The ability to accomplish this integration is currently limited by the processing approaches used to seal lids on pre-etched microfluidic channels. This report describes Sandia's first construction of MEMS instrumented microfluidic chips, which were fabricated by combining our leading capabilities in MEMS processing with our low-temperature photolithographic method for fabricating microfluidic channels. We have explored in-situ cantilevers and other similar passive MEMS devices as a new approach to directly sense fluid transport, and have successfully monitored local flow rates and viscosities within microfluidic channels. Actuated MEMS structures have also been incorporated into microfluidic channels, and the electrical requirements for actuation in liquids have been quantified with an elegant theory. Electrostatic actuation in water has been accomplished, and a novel technique for monitoring local electrical conductivities has been invented.

  8. Automatic sequential fluid handling with multilayer microfluidic sample isolated pumping

    PubMed Central

    Liu, Jixiao; Fu, Hai; Yang, Tianhang; Li, Songjing

    2015-01-01

    To sequentially handle fluids is of great significance in quantitative biology, analytical chemistry, and bioassays. However, the technological options are limited when building such microfluidic sequential processing systems, and one of the encountered challenges is the need for reliable, efficient, and mass-production available microfluidic pumping methods. Herein, we present a bubble-free and pumping-control unified liquid handling method that is compatible with large-scale manufacture, termed multilayer microfluidic sample isolated pumping (mμSIP). The core part of the mμSIP is the selective permeable membrane that isolates the fluidic layer from the pneumatic layer. The air diffusion from the fluidic channel network into the degassing pneumatic channel network leads to fluidic channel pressure variation, which further results in consistent bubble-free liquid pumping into the channels and the dead-end chambers. We characterize the mμSIP by comparing the fluidic actuation processes with different parameters and a flow rate range of 0.013 μl/s to 0.097 μl/s is observed in the experiments. As the proof of concept, we demonstrate an automatic sequential fluid handling system aiming at digital assays and immunoassays, which further proves the unified pumping-control and suggests that the mμSIP is suitable for functional microfluidic assays with minimal operations. We believe that the mμSIP technology and demonstrated automatic sequential fluid handling system would enrich the microfluidic toolbox and benefit further inventions. PMID:26487904

  9. Automatic sequential fluid handling with multilayer microfluidic sample isolated pumping.

    PubMed

    Liu, Jixiao; Fu, Hai; Yang, Tianhang; Li, Songjing

    2015-09-01

    To sequentially handle fluids is of great significance in quantitative biology, analytical chemistry, and bioassays. However, the technological options are limited when building such microfluidic sequential processing systems, and one of the encountered challenges is the need for reliable, efficient, and mass-production available microfluidic pumping methods. Herein, we present a bubble-free and pumping-control unified liquid handling method that is compatible with large-scale manufacture, termed multilayer microfluidic sample isolated pumping (mμSIP). The core part of the mμSIP is the selective permeable membrane that isolates the fluidic layer from the pneumatic layer. The air diffusion from the fluidic channel network into the degassing pneumatic channel network leads to fluidic channel pressure variation, which further results in consistent bubble-free liquid pumping into the channels and the dead-end chambers. We characterize the mμSIP by comparing the fluidic actuation processes with different parameters and a flow rate range of 0.013 μl/s to 0.097 μl/s is observed in the experiments. As the proof of concept, we demonstrate an automatic sequential fluid handling system aiming at digital assays and immunoassays, which further proves the unified pumping-control and suggests that the mμSIP is suitable for functional microfluidic assays with minimal operations. We believe that the mμSIP technology and demonstrated automatic sequential fluid handling system would enrich the microfluidic toolbox and benefit further inventions. PMID:26487904

  10. Bubble pump: scalable strategy for in-plane liquid routing.

    PubMed

    Oskooei, Ali; Günther, Axel

    2015-07-01

    We present an on-chip liquid routing technique intended for application in well-based microfluidic systems that require long-term active pumping at low to medium flowrates. Our technique requires only one fluidic feature layer, one pneumatic control line and does not rely on flexible membranes and mechanical or moving parts. The presented bubble pump is therefore compatible with both elastomeric and rigid substrate materials and the associated scalable manufacturing processes. Directed liquid flow was achieved in a microchannel by an in-series configuration of two previously described "bubble gates", i.e., by gas-bubble enabled miniature gate valves. Only one time-dependent pressure signal is required and initiates at the upstream (active) bubble gate a reciprocating bubble motion. Applied at the downstream (passive) gate a time-constant gas pressure level is applied. In its rest state, the passive gate remains closed and only temporarily opens while the liquid pressure rises due to the active gate's reciprocating bubble motion. We have designed, fabricated and consistently operated our bubble pump with a variety of working liquids for >72 hours. Flow rates of 0-5.5 μl min(-1), were obtained and depended on the selected geometric dimensions, working fluids and actuation frequencies. The maximum operational pressure was 2.9 kPa-9.1 kPa and depended on the interfacial tension of the working fluids. Attainable flow rates compared favorably with those of available micropumps. We achieved flow rate enhancements of 30-100% by operating two bubble pumps in tandem and demonstrated scalability of the concept in a multi-well format with 12 individually and uniformly perfused microchannels (variation in flow rate <7%). We envision the demonstrated concept to allow for the consistent on-chip delivery of a wide range of different liquids that may even include highly reactive or moisture sensitive solutions. The presented bubble pump may provide active flow control for

  11. Our Chaotic Neighbor

    NASA Technical Reports Server (NTRS)

    2006-01-01

    [figure removed for brevity, see original site] Poster Version Large Magellanic Cloud

    This vibrant image from NASA's Spitzer Space Telescope shows the Large Magellanic Cloud, a satellite galaxy to our own Milky Way galaxy.

    The infrared image, a mosaic of more than 100,000 individual tiles, offers astronomers a unique chance to study the lifecycle of stars and dust in a single galaxy. Nearly one million objects are revealed for the first time in this Spitzer view, which represents about a 1,000-fold improvement in sensitivity over previous space-based missions. Most of the new objects are dusty stars of various ages populating the Large Magellanic Cloud; the rest are thought to be background galaxies.

    The blue color in the picture, seen most prominently in the central bar, represents starlight from older stars. The chaotic, bright regions outside this bar are filled with hot, massive stars buried in thick blankets of dust. The red clouds contain cooler interstellar gas and molecular-sized dust grains illuminated by ambient starlight.

    The Large Magellanic Cloud, located 160,000 light-years from Earth, is one of a handful of dwarf galaxies that orbit our own Milky Way. It is approximately one-third as wide as the Milky Way, and, if it could be seen in its entirety, would cover the same amount of sky as a grid of about 480 full moons. About one-third of the whole galaxy can be seen in the Spitzer image.

    This picture is a composite of infrared light captured by Spitzer's infrared array camera. Light with wavelengths of 8 and 5.8 microns is red and orange: 4.5-micron light is green; and 3.6-micron light is blue.

  12. Bubbles, Bubbles: Integrated Investigations with Floating Spheres

    ERIC Educational Resources Information Center

    Reeder, Stacy

    2007-01-01

    In this article, the author describes integrated science and mathematics activities developed for fourth-grade students to explore and investigate three-dimensional geometric shapes, Bernoulli's principle, estimation, and art with and through bubbles. Students were engaged in thinking and reflection on the questions their teachers asked and were…

  13. Bubble dynamics in a standing sound field: the bubble habitat.

    PubMed

    Koch, P; Kurz, T; Parlitz, U; Lauterborn, W

    2011-11-01

    Bubble dynamics is investigated numerically with special emphasis on the static pressure and the positional stability of the bubble in a standing sound field. The bubble habitat, made up of not dissolving, positionally and spherically stable bubbles, is calculated in the parameter space of the bubble radius at rest and sound pressure amplitude for different sound field frequencies, static pressures, and gas concentrations of the liquid. The bubble habitat grows with static pressure and shrinks with sound field frequency. The range of diffusionally stable bubble oscillations, found at positive slopes of the habitat-diffusion border, can be increased substantially with static pressure. PMID:22088010

  14. Determining Chaotic Instabilities in Mechanical Systems

    NASA Technical Reports Server (NTRS)

    Zak, M. A.

    1986-01-01

    Theoretical developments enable suppression of chaotic structual motions. Theory enables prediction, avoidance, and suppression of chaotic vibrations in structures, especially using dynamic feedback stabilization. In new formulation, motion both repeatable and predictable.

  15. Tribonucleation of bubbles

    PubMed Central

    Wildeman, Sander; Lhuissier, Henri; Sun, Chao; Lohse, Detlef; Prosperetti, Andrea

    2014-01-01

    We report on the nucleation of bubbles on solids that are gently rubbed against each other in a liquid. The phenomenon is found to depend strongly on the material and roughness of the solid surfaces. For a given surface, temperature, and gas content, a trail of growing bubbles is observed if the rubbing force and velocity exceed a certain threshold. Direct observation through a transparent solid shows that each bubble in the trail results from the early coalescence of several microscopic bubbles, themselves detaching from microscopic gas pockets forming between the solids. From a detailed study of the wear tracks, with atomic force and scanning electron microscopy imaging, we conclude that these microscopic gas pockets originate from a local fracturing of the surface asperities, possibly enhanced by chemical reactions at the freshly created surfaces. Our findings will be useful either for preventing undesired bubble formation or, on the contrary, for “writing with bubbles,” i.e., creating controlled patterns of microscopic bubbles. PMID:24982169

  16. Chaotic mixer using electro-osmosis at finite Péclet number

    NASA Astrophysics Data System (ADS)

    Sugioka, Hideyuki

    2010-03-01

    Two pressure-driven streams of two miscible liquids can only mix by diffusion in microfluidic channels because of the low Reynolds number. We present an idea to generate mixing by “chaotic advection” in microscale geometries. That is, we consider using induced-charge electro-osmosis to generate a second flow and then modulate between the pressure-driven and induced-charge flows. By using the combined method consisting of the boundary element method, the Lagrangian particle tracking method, and the random-walk method, we analyze mixing efficiency, mixing time, and mixing length, with the effects of modulation frequency and molecular diffusivity, and compare our proposed mixer with other mixers. By this analysis, we find that chaotic mixing can be produced efficiently in a microfluidic channel by switching between pressure-driven and induced-charge flows in a wide range of Péclet number under the specific condition of Strouhal number. By using our proposed mixer, we can expect to realize efficient chaotic mixing with minimum voltage in an ordinary flow channel with a simple structure without an oblique electric field even at large Péclet number.

  17. Chaotic advection of immiscible fluids

    NASA Astrophysics Data System (ADS)

    Vollmayr-Lee, Benjamin; Beller, Daniel; Yasuda, Sohei

    2012-02-01

    We consider a system of two immiscible fluids advected by a chaotic flow field. A nonequilibrium steady state arises from the competition between the coarsening of the immiscible fluids and the domain bursting caused by the chaotic flow. It has been established that the average domain size in this steady state scales as a inverse power of the Lyapunov exponent. We examine the issue of local structure and look for correlations between the local domain size and the finite-time Lyapunov exponent (FTLE) field. For a variety of chaotic flows, we consistently find the domains to be smallest in regions where the FTLE field is maximal. This raises the possibility of making universal predictions of steady-state characteristics based on Lyapunov analysis of the flow field.

  18. CHAOTIC ZONES AROUND GRAVITATING BINARIES

    SciTech Connect

    Shevchenko, Ivan I.

    2015-01-20

    The extent of the continuous zone of chaotic orbits of a small-mass tertiary around a system of two gravitationally bound primaries of comparable masses (a binary star, a binary black hole, a binary asteroid, etc.) is estimated analytically, as a function of the tertiary's orbital eccentricity. The separatrix map theory is used to demonstrate that the central continuous chaos zone emerges (above a threshold in the primaries' mass ratio) due to overlapping of the orbital resonances corresponding to the integer ratios p:1 between the tertiary and the central binary periods. In this zone, the unlimited chaotic orbital diffusion of the tertiary takes place, up to its ejection from the system. The primaries' mass ratio, above which such a chaotic zone is universally present at all initial eccentricities of the tertiary, is estimated. The diversity of the observed orbital configurations of biplanetary and circumbinary exosystems is shown to be in accord with the existence of the primaries' mass parameter threshold.

  19. Chaotic synchronization system and electrocardiogram

    NASA Astrophysics Data System (ADS)

    Pei, Liuqing; Dai, Xinlai; Li, Baodong

    1997-01-01

    A mathematical model of chaotic synchronization of the heart-blood flow coupling dynamics is proposed, which is based on a seven dimension nonlinear dynamical system constructed by three subsystems of the sinoatrial node natural pacemaker, the cardiac relaxation oscillator and the dynamics of blood-fluid in heart chambers. The existence and robustness of the self-chaotic synchronization of the system are demonstrated by both methods of theoretical analysis and numerical simulation. The spectrum of Lyapunov exponent, the Lyapunov dimension and the Kolmogorov entropy are estimated when the system was undergoing the state of self-chaotic synchronization evolution. The time waveform of the dynamical variable, which represents the membrane potential of the cardiac integrative cell, shows a shape which is similar to that of the normal electrocardiogram (ECG) of human, thus implies that the model possesses physiological significance functionally.

  20. Analysis of rattleback chaotic oscillations.

    PubMed

    Hanias, Michael; Stavrinides, Stavros G; Banerjee, Santo

    2014-01-01

    Rattleback is a canoe-shaped object, already known from ancient times, exhibiting a nontrivial rotational behaviour. Although its shape looks symmetric, its kinematic behaviour seems to be asymmetric. When spun in one direction it normally rotates, but when it is spun in the other direction it stops rotating and oscillates until it finally starts rotating in the other direction. It has already been reported that those oscillations demonstrate chaotic characteristics. In this paper, rattleback's chaotic dynamics are studied by applying Kane's model for different sets of (experimentally decided) parameters, which correspond to three different experimental prototypes made of wax, gypsum, and lead-solder. The emerging chaotic behaviour in all three cases has been studied and evaluated by the related time-series analysis and the calculation of the strange attractors' invariant parameters. PMID:24511290

  1. Analysis of Rattleback Chaotic Oscillations

    PubMed Central

    Stavrinides, Stavros G.; Banerjee, Santo

    2014-01-01

    Rattleback is a canoe-shaped object, already known from ancient times, exhibiting a nontrivial rotational behaviour. Although its shape looks symmetric, its kinematic behaviour seems to be asymmetric. When spun in one direction it normally rotates, but when it is spun in the other direction it stops rotating and oscillates until it finally starts rotating in the other direction. It has already been reported that those oscillations demonstrate chaotic characteristics. In this paper, rattleback's chaotic dynamics are studied by applying Kane's model for different sets of (experimentally decided) parameters, which correspond to three different experimental prototypes made of wax, gypsum, and lead-solder. The emerging chaotic behaviour in all three cases has been studied and evaluated by the related time-series analysis and the calculation of the strange attractors' invariant parameters. PMID:24511290

  2. Punch card programmable microfluidics.

    PubMed

    Korir, George; Prakash, Manu

    2015-01-01

    Small volume fluid handling in single and multiphase microfluidics provides a promising strategy for efficient bio-chemical assays, low-cost point-of-care diagnostics and new approaches to scientific discoveries. However multiple barriers exist towards low-cost field deployment of programmable microfluidics. Incorporating multiple pumps, mixers and discrete valve based control of nanoliter fluids and droplets in an integrated, programmable manner without additional required external components has remained elusive. Combining the idea of punch card programming with arbitrary fluid control, here we describe a self-contained, hand-crank powered, multiplex and robust programmable microfluidic platform. A paper tape encodes information as a series of punched holes. A mechanical reader/actuator reads these paper tapes and correspondingly executes operations onto a microfluidic chip coupled to the platform in a plug-and-play fashion. Enabled by the complexity of codes that can be represented by a series of holes in punched paper tapes, we demonstrate independent control of 15 on-chip pumps with enhanced mixing, normally-closed valves and a novel on-demand impact-based droplet generator. We demonstrate robustness of operation by encoding a string of characters representing the word "PUNCHCARD MICROFLUIDICS" using the droplet generator. Multiplexing is demonstrated by implementing an example colorimetric water quality assays for pH, ammonia, nitrite and nitrate content in different water samples. With its portable and robust design, low cost and ease-of-use, we envision punch card programmable microfluidics will bring complex control of microfluidic chips into field-based applications in low-resource settings and in the hands of children around the world. PMID:25738834

  3. Punch card programmable microfluidics.

    PubMed

    Korir, George; Prakash, Manu

    2015-01-01

    Small volume fluid handling in single and multiphase microfluidics provides a promising strategy for efficient bio-chemical assays, low-cost point-of-care diagnostics and new approaches to scientific discoveries. However multiple barriers exist towards low-cost field deployment of programmable microfluidics. Incorporating multiple pumps, mixers and discrete valve based control of nanoliter fluids and droplets in an integrated, programmable manner without additional required external components has remained elusive. Combining the idea of punch card programming with arbitrary fluid control, here we describe a self-contained, hand-crank powered, multiplex and robust programmable microfluidic platform. A paper tape encodes information as a series of punched holes. A mechanical reader/actuator reads these paper tapes and correspondingly executes operations onto a microfluidic chip coupled to the platform in a plug-and-play fashion. Enabled by the complexity of codes that can be represented by a series of holes in punched paper tapes, we demonstrate independent control of 15 on-chip pumps with enhanced mixing, normally-closed valves and a novel on-demand impact-based droplet generator. We demonstrate robustness of operation by encoding a string of characters representing the word "PUNCHCARD MICROFLUIDICS" using the droplet generator. Multiplexing is demonstrated by implementing an example colorimetric water quality assays for pH, ammonia, nitrite and nitrate content in different water samples. With its portable and robust design, low cost and ease-of-use, we envision punch card programmable microfluidics will bring complex control of microfluidic chips into field-based applications in low-resource settings and in the hands of children around the world.

  4. Cosmic bubble collisions

    NASA Astrophysics Data System (ADS)

    Kleban, Matthew

    2011-10-01

    I briefly review the physics of cosmic bubble collisions in false-vacuum eternal inflation. My purpose is to provide an introduction to the subject for readers unfamiliar with it, focussing on recent work related to the prospects for observing the effects of bubble collisions in cosmology. I will attempt to explain the essential physical points as simply and concisely as possible, leaving most technical details to the references. I make no attempt to be comprehensive or complete. I also present a new solution to Einstein's equations that represents a bubble universe after a collision, containing vacuum energy and ingoing null radiation with an arbitrary density profile.

  5. Rotating bubble membrane radiator

    DOEpatents

    Webb, Brent J.; Coomes, Edmund P.

    1988-12-06

    A heat radiator useful for expelling waste heat from a power generating system aboard a space vehicle is disclosed. Liquid to be cooled is passed to the interior of a rotating bubble membrane radiator, where it is sprayed into the interior of the bubble. Liquid impacting upon the interior surface of the bubble is cooled and the heat radiated from the outer surface of the membrane. Cooled liquid is collected by the action of centrifical force about the equator of the rotating membrane and returned to the power system. Details regarding a complete space power system employing the radiator are given.

  6. Forward glory scattering from bubbles.

    PubMed

    Langley, D S; Marston, P L

    1991-08-20

    The scattering enhancement known as the glory was observed in forward scattering from bubbles in liquids. A physical-optics model of the forward glory is detailed, based on transmitted waves reflected within the bubble. Some aspects of the model are compared with the Mie theory and with features in the cross-polarized light from single bubbles. Clouds of small bubbles rising in water show an angular structure in the forward glory light that is useful for estimating the bubble size.

  7. What's in a Bubble?

    ERIC Educational Resources Information Center

    Saunderson, Megan

    2000-01-01

    Describes a unit on detergents and bubbles that establishes an interest in the properties of materials and focuses on active learning involving both hands- and minds-on learning rather than passive learning. (ASK)

  8. Blowing magnetic skyrmion bubbles

    NASA Astrophysics Data System (ADS)

    Jiang, Wanjun; Upadhyaya, Pramey; Zhang, Wei; Yu, Guoqiang; Jungfleisch, M. Benjamin; Fradin, Frank Y.; Pearson, John E.; Tserkovnyak, Yaroslav; Wang, Kang L.; Heinonen, Olle; te Velthuis, Suzanne G. E.; Hoffmann, Axel

    2015-07-01

    The formation of soap bubbles from thin films is accompanied by topological transitions. Here we show how a magnetic topological structure, a skyrmion bubble, can be generated in a solid-state system in a similar manner. Using an inhomogeneous in-plane current in a system with broken inversion symmetry, we experimentally “blow” magnetic skyrmion bubbles from a geometrical constriction. The presence of a spatially divergent spin-orbit torque gives rise to instabilities of the magnetic domain structures that are reminiscent of Rayleigh-Plateau instabilities in fluid flows. We determine a phase diagram for skyrmion formation and reveal the efficient manipulation of these dynamically created skyrmions, including depinning and motion. The demonstrated current-driven transformation from stripe domains to magnetic skyrmion bubbles could lead to progress in skyrmion-based spintronics.

  9. Chemistry in Soap Bubbles.

    ERIC Educational Resources Information Center

    Lee, Albert W. M.; Wong, A.; Lee, H. W.; Lee, H. Y.; Zhou, Ning-Huai

    2002-01-01

    Describes a laboratory experiment in which common chemical gases are trapped inside soap bubbles. Examines the physical and chemical properties of the gases such as relative density and combustion. (Author/MM)

  10. Blowing DNA bubbles.

    PubMed

    Severin, N; Zhuang, W; Ecker, C; Kalachev, A A; Sokolov, I M; Rabe, J P

    2006-11-01

    We report here experimental observations which indicate that topologically or covalently formed polymer loops embedded in an ultrathin liquid film on a solid substrate can be "blown" into circular "bubbles" during scanning force microscopy (SFM) imaging. In particular, supercoiled vector DNA has been unraveled, moved, stretched, and overstretched to two times its B-form length and then torn apart. We attribute the blowing of the DNA bubbles to the interaction of the tapping SFM tip with the ultrathin liquid film.

  11. Bubble coalescence in magmas

    NASA Technical Reports Server (NTRS)

    Herd, Richard A.; Pinkerton, Harry

    1993-01-01

    The most important factors governing the nature of volcanic eruptions are the primary volatile contents, the ways in which volatiles exsolve, and how the resulting bubbles grow and interact. In this contribution we assess the importance of bubble coalescence. The degree of coalescence in alkali basalts has been measured using Image Analysis techniques and it is suggested to be a process of considerable importance. Binary coalescence events occur every few minutes in basaltic melts with vesicularities greater than around 35 percent.

  12. Clustering in Bubble Suspensions

    NASA Astrophysics Data System (ADS)

    Zenit, Roberto

    2000-11-01

    A monidisperse bubble suspension is studied experimentally for the limit in which the Weber number is small and the Reynolds number is large. For this regime the suspension can be modeled using potential flow theory to describe the dynamics of the interstitial fluid. Complete theoretical descriptions have been composed (Spelt and Sangani, 1998) to model the behavior of these suspensions. Bubble clustering is a natural instability that arises from the potential flow considerations, in which bubbles tend to align in horizontal rafts as they move upwards. The appearance of bubble clusters was recently corroborated experimentally by Zenit et al. (2000), who found that although clusters did appear, their strength was not as strong as the predictions. Experiments involving gravity driven shear flows are used to explain the nature of the clustering observed in these type of flows. Balances of the bubble phase pressure (in terms of a calculated diffusion coefficient) and the Maxwell pressure (from the potential flow description) are presented to predict the stability of the bubble suspension. The predictions are compared with experimental results.

  13. Microfluidic Mixing: A Review

    PubMed Central

    Lee, Chia-Yen; Chang, Chin-Lung; Wang, Yao-Nan; Fu, Lung-Ming

    2011-01-01

    The aim of microfluidic mixing is to achieve a thorough and rapid mixing of multiple samples in microscale devices. In such devices, sample mixing is essentially achieved by enhancing the diffusion effect between the different species flows. Broadly speaking, microfluidic mixing schemes can be categorized as either “active”, where an external energy force is applied to perturb the sample species, or “passive”, where the contact area and contact time of the species samples are increased through specially-designed microchannel configurations. Many mixers have been proposed to facilitate this task over the past 10 years. Accordingly, this paper commences by providing a high level overview of the field of microfluidic mixing devices before describing some of the more significant proposals for active and passive mixers. PMID:21686184

  14. Microfluidic platforms for mechanobiology

    PubMed Central

    Polacheck, William J.; Li, Ran; Uzel, Sebastien G. M.

    2013-01-01

    Mechanotransduction has been a topic of considerable interest since early studies demonstrated a link between mechanical force and biological response. Until recently, studies of fundamental phenomena were based either on in vivo experiments with limited control or direct access, or on large-scale in vitro studies lacking many of the potentially important physiological factors. With the advent of microfluidics, many of the previous limitations of in vitro testing were eliminated or reduced through greater control or combined functionalities. At the same time, imaging capabilities were tremendously enhanced. In this review, we discuss how microfluidics has transformed the study of mechanotransduction. This is done in the context of the various cell types that exhibit force-induced responses and the new biological insights that have been elucidated. We also discuss new microfluidic studies that could produce even more realistic models of in vivo conditions by combining multiple stimuli or creating a more realistic microenvironment. PMID:23649165

  15. Learning in a Chaotic Environment

    ERIC Educational Resources Information Center

    Goldman, Ellen; Plack, Margaret; Roche, Colleen; Smith, Jeffrey; Turley, Catherine

    2009-01-01

    Purpose: The purpose of this study is to understand how, when, and why emergency medicine residents learn while working in the chaotic environment of a hospital emergency room. Design/methodology/approach: This research used a qualitative interview methodology with thematic data analysis that was verified with the entire population of learners.…

  16. A modified chaotic cryptographic method

    NASA Astrophysics Data System (ADS)

    Wong, Wai-kit; Lee, Lap-piu; Wong, Kwok-wo

    2001-08-01

    We propose a modified version of the chaotic cryptographic method based on iterating a logistic map. Simulation results show that the distribution of the ciphertext is flatter and the encryption time is shorter. Moreover, the trade-off between the spread of the distribution of ciphertext and the encryption time can be controlled by a single parameter.

  17. Punch Card Programmable Microfluidics

    PubMed Central

    Korir, George; Prakash, Manu

    2015-01-01

    Small volume fluid handling in single and multiphase microfluidics provides a promising strategy for efficient bio-chemical assays, low-cost point-of-care diagnostics and new approaches to scientific discoveries. However multiple barriers exist towards low-cost field deployment of programmable microfluidics. Incorporating multiple pumps, mixers and discrete valve based control of nanoliter fluids and droplets in an integrated, programmable manner without additional required external components has remained elusive. Combining the idea of punch card programming with arbitrary fluid control, here we describe a self-contained, hand-crank powered, multiplex and robust programmable microfluidic platform. A paper tape encodes information as a series of punched holes. A mechanical reader/actuator reads these paper tapes and correspondingly executes operations onto a microfluidic chip coupled to the platform in a plug-and-play fashion. Enabled by the complexity of codes that can be represented by a series of holes in punched paper tapes, we demonstrate independent control of 15 on-chip pumps with enhanced mixing, normally-closed valves and a novel on-demand impact-based droplet generator. We demonstrate robustness of operation by encoding a string of characters representing the word “PUNCHCARD MICROFLUIDICS” using the droplet generator. Multiplexing is demonstrated by implementing an example colorimetric water quality assays for pH, ammonia, nitrite and nitrate content in different water samples. With its portable and robust design, low cost and ease-of-use, we envision punch card programmable microfluidics will bring complex control of microfluidic chips into field-based applications in low-resource settings and in the hands of children around the world. PMID:25738834

  18. Macromolecular Crystal Growth by Means of Microfluidics

    NASA Technical Reports Server (NTRS)

    vanderWoerd, Mark; Ferree, Darren; Spearing, Scott; Monaco, Lisa; Molho, Josh; Spaid, Michael; Brasseur, Mike; Curreri, Peter A. (Technical Monitor)

    2002-01-01

    We have performed a feasibility study in which we show that chip-based, microfluidic (LabChip(TM)) technology is suitable for protein crystal growth. This technology allows for accurate and reliable dispensing and mixing of very small volumes while minimizing bubble formation in the crystallization mixture. The amount of (protein) solution remaining after completion of an experiment is minimal, which makes this technique efficient and attractive for use with proteins, which are difficult or expensive to obtain. The nature of LabChip(TM) technology renders it highly amenable to automation. Protein crystals obtained in our initial feasibility studies were of excellent quality as determined by X-ray diffraction. Subsequent to the feasibility study, we designed and produced the first LabChip(TM) device specifically for protein crystallization in batch mode. It can reliably dispense and mix from a range of solution constituents into two independent growth wells. We are currently testing this design to prove its efficacy for protein crystallization optimization experiments. In the near future we will expand our design to incorporate up to 10 growth wells per LabChip(TM) device. Upon completion, additional crystallization techniques such as vapor diffusion and liquid-liquid diffusion will be accommodated. Macromolecular crystallization using microfluidic technology is envisioned as a fully automated system, which will use the 'tele-science' concept of remote operation and will be developed into a research facility for the International Space Station as well as on the ground.

  19. Microfluidic Flame Barrier

    NASA Technical Reports Server (NTRS)

    Mungas, Gregory S. (Inventor); Fisher, David J. (Inventor); Mungas, Christopher (Inventor)

    2013-01-01

    Propellants flow through specialized mechanical hardware that is designed for effective and safe ignition and sustained combustion of the propellants. By integrating a micro-fluidic porous media element between a propellant feed source and the combustion chamber, an effective and reliable propellant injector head may be implemented that is capable of withstanding transient combustion and detonation waves that commonly occur during an ignition event. The micro-fluidic porous media element is of specified porosity or porosity gradient selected to be appropriate for a given propellant. Additionally the propellant injector head design integrates a spark ignition mechanism that withstands extremely hot running conditions without noticeable spark mechanism degradation.

  20. Experimental Microfluidic System

    NASA Technical Reports Server (NTRS)

    Culbertson, Christopher; Gonda, Steve; Ramsey, John Michael

    2005-01-01

    The ultimate goal of this project is to integrate microfluidic devices with NASA's space bioreactor systems. In such a system, the microfluidic device would provide realtime feedback control of the bioreactor by monitoring pH, glucose, and lactate levels in the cell media; and would provide an analytical capability to the bioreactor in exterrestrial environments for monitoring bioengineered cell products and health changes in cells due to environmental stressors. Such integrated systems could be used as biosentinels both in space and on planet surfaces. The objective is to demonstrate the ability of microfabricated devices to repeatedly and reproducibly perform bead cytometry experiments in micro, lunar, martian, and hypergravity (1.8g).

  1. Visibility graphlet approach to chaotic time series.

    PubMed

    Mutua, Stephen; Gu, Changgui; Yang, Huijie

    2016-05-01

    Many novel methods have been proposed for mapping time series into complex networks. Although some dynamical behaviors can be effectively captured by existing approaches, the preservation and tracking of the temporal behaviors of a chaotic system remains an open problem. In this work, we extended the visibility graphlet approach to investigate both discrete and continuous chaotic time series. We applied visibility graphlets to capture the reconstructed local states, so that each is treated as a node and tracked downstream to create a temporal chain link. Our empirical findings show that the approach accurately captures the dynamical properties of chaotic systems. Networks constructed from periodic dynamic phases all converge to regular networks and to unique network structures for each model in the chaotic zones. Furthermore, our results show that the characterization of chaotic and non-chaotic zones in the Lorenz system corresponds to the maximal Lyapunov exponent, thus providing a simple and straightforward way to analyze chaotic systems.

  2. Sound synchronization of bubble trains in a viscous fluid: experiment and modeling.

    PubMed

    Pereira, Felipe Augusto Cardoso; Baptista, Murilo da Silva; Sartorelli, José Carlos

    2014-10-01

    We investigate the dynamics of formation of air bubbles expelled from a nozzle immersed in a viscous fluid under the influence of sound waves. We have obtained bifurcation diagrams by measuring the time between successive bubbles, having the air flow (Q) as a parameter control for many values of the sound wave amplitude (A), the height (H) of the solution above the top of the nozzle, and three values of the sound frequency (fs). Our parameter spaces (Q,A) revealed a scenario for the onset of synchronization dominated by Arnold tongues (frequency locking) which gives place to chaotic phase synchronization for sufficiently large A. The experimental results were accurately reproduced by numerical simulations of a model combining a simple bubble growth model for the bubble train and a coupling term with the sound wave added to the equilibrium pressure.

  3. The Onset of Resonance-Controlled Instability in Spherical Bubble Oscillations

    NASA Technical Reports Server (NTRS)

    Holt, R. Glynn; Gaitan, D. Felipe

    1996-01-01

    Single bubble dynamics are investigated using acoustic techniques for isolation and manipulation. The goal of the investigations is to understand the dynamic origin of the various phenomena that bubbles exhibit: light emission, enhanced mass transport, chaotic and quasiperiodic oscillations, and translations. Once understood, acoustically manipulated bubbles can serve as platforms for materials effects on free surfaces, using surfactants to alter surface rheology and observing how that affects both dynamics and also mass transport. The effects of gravity on the problem will be shown to be significant. The first set of observations from 1g experimentation are presented. These observations are of the onset conditions for instability of the spherical shape of the bubble. For the size range 55-90 microns in diameter we observe instability governed by resonant mode coupling, which is significantly affected by the buoyant force and its effects.

  4. Fast bubble dynamics and sizing

    NASA Astrophysics Data System (ADS)

    Czarnecki, Krzysztof; Fouan, Damien; Achaoui, Younes; Mensah, Serge

    2015-11-01

    Single bubble sizing is usually performed by measuring the resonant bubble response using the Dual Frequency Ultrasound Method. However, in practice, the use of millisecond-duration chirp-like waves yields nonlinear distortions of the bubble oscillations. In comparison with the resonant curve obtained under harmonic excitation, it was observed that the bubble dynamic response shifted by up to 20 percent of the resonant frequency with bubble radii of less than 100 μm. In the case of low pressure waves (P < 5 kPa), an approximate formula for the apparent frequency shift is derived. Simulated and experimental bubble responses are analyzed in the time-frequency domain using an enhanced concentrated (reassigned) spectrogram. The difference in the resonant frequency resulted from the persistence of the resonant mode in the bubble response. Numerical simulations in which these findings are extended to pairs of coupled bubbles and to bubble clouds are also presented.

  5. Investigation of Current Hotspots on an Ion-Selective Membrane Subject to Chaotic Electroconvection

    NASA Astrophysics Data System (ADS)

    Druzgalski, Clara

    2015-11-01

    We have performed a 3D direct numerical simulation (DNS) of chaotic ion transport associated with electroconvective instability near an ion-selective membrane. Data from the 3D DNS demonstrate that the chaotic fluid motion substantially influences the transport of ions and causes instantaneous hotspots of high current density on the surface. We present a comprehensive statistical analysis of surface current density, including probability density functions (PDFs) and joint-PDFs with other interfacial measures involving flow, conductivity and electric fields. These results provide new insights into the mechanism and characterization of current hotspots. Our results are relevant to industrial applications involving ion-selective interfaces such as electrodialysis for water purification, and emerging microfluidic devices that use ion-selective components for separation processes.

  6. Interaction of droplets in recirculation regions within microfluidic systems

    NASA Astrophysics Data System (ADS)

    Ghazi, Nastaran; Hosseini, Ashkan; Shojaei-Zadeh, Shahab

    2012-11-01

    We investigate the interaction of oil droplets in continuous water phase as they travel across the streamlines of a recirculation region using microfluidic devices. Oil droplets are first generated using hydrodynamic focusing and then enter a recirculation region. The droplets then keep recirculating until they are pushed out by the incoming ones. We show that the frequency of droplet generation, viscosity contrast (oil to water), and geometry determine which droplets to stay in the recirculation region and which one to leave. Using flow field simulations, we investigate the migration of droplets and their trajectories based on the geometry of the recirculation region, the bubble size, and fluid properties. Under favorable conditions, when droplets interact within the recirculation region for long enough time, the film thickness that separates the two interfaces reduces and droplets will coalesce. The proposed design thus provides a suitable platform to study droplet coalescence within microfluidic devices.

  7. Sonication-microfluidics for fabrication of nanoparticle-stabilized microbubbles.

    PubMed

    Chen, Haosheng; Li, Jiang; Zhou, Weizheng; Pelan, Eddie G; Stoyanov, Simeon D; Arnaudov, Luben N; Stone, Howard A

    2014-04-22

    An approach based upon sonication-microfluidics is presented to fabricate nanoparticle-coated microbubbles. The gas-in-liquid slug flow formed in a microchannel is subjected to ultrasound, leading to cavitation at the gas-liquid interface. Therefore, microbubbles are formed and then stabilized by the nanoparticles contained in the liquid. Compared to the conventional sonication method, this sonication-microfluidics continuous flow approach has unlimited gas nuclei for cavitation that yields continuous production of foam with shorter residence time. By controlling the flow rate ratios of the gas to the liquid, this method also achieves a higher production volume, smaller bubble size, and less waste of the nanoparticles needed to stabilize the microbubbles.

  8. The dynamics of histotripsy bubbles

    NASA Astrophysics Data System (ADS)

    Kreider, Wayne; Bailey, Michael R.; Sapozhnikov, Oleg A.; Khokhlova, Vera A.; Crum, Lawrence A.

    2011-09-01

    Histotripsy describes treatments in which high-amplitude acoustic pulses are used to excite bubbles and erode tissue. Though tissue erosion can be directly attributed to bubble activity, the genesis and dynamics of bubbles remain unclear. Histotripsy lesions that show no signs of thermal coagulative damage have been generated with two different acoustic protocols: relatively long acoustic pulses that produce local boiling within milliseconds and relatively short pulses that are higher in amplitude but likely do not produce boiling. While these two approaches are often distinguished as `boiling' versus `cavitation', such labels can obscure similarities. In both cases, a bubble undergoes large changes in radius and vapor is transported into and out of the bubble as it oscillates. Moreover, observations from both approaches suggest that bubbles grow to a size at which they cease to collapse violently. In order to better understand the dynamics of histotripsy bubbles, a single-bubble model has been developed that couples acoustically excited bubble motions to the thermodynamic state of the surrounding liquid. Using this model for bubbles exposed to histotripsy sound fields, simulations suggest that two mechanisms can act separately or in concert to lead to the typically observed bubble growth. First, nonlinear acoustic propagation leads to the evolution of shocks and an asymmetry in the positive and negative pressures that drive bubble motion. This asymmetry can have a rectifying effect on bubble oscillations whereby the bubble grows on average during each acoustic cycle. Second, vapor transport to/from the bubble tends to produce larger bubbles, especially at elevated temperatures. Vapor transport by itself can lead to rectified bubble growth when the ambient temperature exceeds 100 °C (`boiling') or local heating in the vicinity of the bubble leads to a superheated boundary layer.

  9. Statistical equilibrium of bubble oscillations in dilute bubbly flows

    PubMed Central

    Colonius, Tim; Hagmeijer, Rob; Ando, Keita; Brennen, Christopher E.

    2008-01-01

    The problem of predicting the moments of the distribution of bubble radius in bubbly flows is considered. The particular case where bubble oscillations occur due to a rapid (impulsive or step change) change in pressure is analyzed, and it is mathematically shown that in this case, inviscid bubble oscillations reach a stationary statistical equilibrium, whereby phase cancellations among bubbles with different sizes lead to time-invariant values of the statistics. It is also shown that at statistical equilibrium, moments of the bubble radius may be computed using the period-averaged bubble radius in place of the instantaneous one. For sufficiently broad distributions of bubble equilibrium (or initial) radius, it is demonstrated that bubble statistics reach equilibrium on a time scale that is fast compared to physical damping of bubble oscillations due to viscosity, heat transfer, and liquid compressibility. The period-averaged bubble radius may then be used to predict the slow changes in the moments caused by the damping. A benefit is that period averaging gives a much smoother integrand, and accurate statistics can be obtained by tracking as few as five bubbles from the broad distribution. The period-averaged formula may therefore prove useful in reducing computational effort in models of dilute bubbly flow wherein bubbles are forced by shock waves or other rapid pressure changes, for which, at present, the strong effects caused by a distribution in bubble size can only be accurately predicted by tracking thousands of bubbles. Some challenges associated with extending the results to more general (nonimpulsive) forcing and strong two-way coupled bubbly flows are briefly discussed. PMID:19547725

  10. Colliding with a crunching bubble

    SciTech Connect

    Freivogel, Ben; Freivogel, Ben; Horowitz, Gary T.; Shenker, Stephen

    2007-03-26

    In the context of eternal inflation we discuss the fate of Lambda = 0 bubbles when they collide with Lambda< 0 crunching bubbles. When the Lambda = 0 bubble is supersymmetric, it is not completely destroyed by collisions. If the domain wall separating the bubbles has higher tension than the BPS bound, it is expelled from the Lambda = 0 bubble and does not alter its long time behavior. If the domain wall saturates the BPS bound, then it stays inside the Lambda = 0 bubble and removes a finite fraction of future infinity. In this case, the crunch singularity is hidden behind the horizon of a stable hyperbolic black hole.

  11. Acousto-plasmofluidics: Acoustic modulation of surface plasmon resonance in microfluidic systems

    NASA Astrophysics Data System (ADS)

    Ahmed, Daniel; Peng, Xiaolei; Ozcelik, Adem; Zheng, Yuebing; Huang, Tony Jun

    2015-09-01

    We acoustically modulated the localized surface plasmon resonances (LSPRs) of metal nanostructures integrated within microfluidic systems. An acoustically driven micromixing device based on bubble microstreaming quickly and homogeneously mixes multiple laminar flows of different refractive indices. The altered refractive index of the mixed fluids enables rapid modulation of the LSPRs of gold nanodisk arrays embedded within the microfluidic channel. The device features fast response for dynamic operation, and the refractive index within the channel is tailorable. With these unique features, our "acousto-plasmofluidic" device can be useful in applications such as optical switches, modulators, filters, biosensors, and lab-on-a-chip systems.

  12. Chemistry in Microfluidic Channels

    ERIC Educational Resources Information Center

    Chia, Matthew C.; Sweeney, Christina M.; Odom, Teri W.

    2011-01-01

    General chemistry introduces principles such as acid-base chemistry, mixing, and precipitation that are usually demonstrated in bulk solutions. In this laboratory experiment, we describe how chemical reactions can be performed in a microfluidic channel to show advanced concepts such as laminar fluid flow and controlled precipitation. Three sets of…

  13. Investigation of bubble-bubble interaction effect during the collapse of multi-bubble system

    NASA Astrophysics Data System (ADS)

    Shao, Xueming; Zhang, Lingxin; Wang, Wenfeng

    2014-11-01

    Bubble collapse is not only an important subject among bubble dynamics, but also a key consequence of cavitation. It has been demonstrated that the structural damage is associated with the rapid change in flow fields during bubble collapse. How to model and simulate the behavior of the bubble collapse is now of great interest. In the present study, both theoretical analysis and a direct numerical simulation on the basis of VOF are performed to investigate the collapses of single bubble and bubble cluster. The effect of bubble-bubble interaction on the collapse of multi-bubble system is presented. The work was supported by the National Natural Science Foundation of China (11272284, 11332009).

  14. The Dueling Bubble Experiment

    NASA Astrophysics Data System (ADS)

    Roy, Anshuman; Borrell, Marcos; Felts, John; Leal, Gary; Hirsa, Amir

    2007-11-01

    When two drops or bubbles are brought into close proximity to each other, the thin film of the fluid between them drains as they are squeezed together. If the film becomes thin enough that intermolecular forces of attraction overwhelm capillary forces, the drops/bubbles coalesce and the time it takes for this to happen, starting from the point of apparent contact is referred to as the drainage time. One practical version of this scenario occurs during the formation of foams, when the thin film forms between gas bubbles that are growing in volume with time. We performed an experimental study that is intended to mimic this process in which the two drops (or bubbles) in the size range of 50-100 microns diameter are created by oozing a liquid/gas out of two capillaries of diameter less than 100 microns directly facing each other and immersed in a second fluid. We present measurements of drainage times for the cases of very low viscosity ratios PDMS drops in Castor oil (less than 0.05) and bubbles of air in PDMS, and highlight the differences that arise in part due to the different boundary conditions for thin film drainage for liquid-liquid versus gas-liquid systems, and in part due to the different Hamaker constants for the two systems.

  15. Micro bubbles at interfaces

    NASA Astrophysics Data System (ADS)

    Keshavarzi, Gholamreza; Wang, Anna; Barber, Tracie; Manoharan, Vinothan

    2014-03-01

    The behaviour of a small micron sized bubbles close to an interface is vital to various interface interaction applications in several industries. Previous studies have focused on understanding the behaviour of large millimetric bubbles reaching an interface. Some of these millimetric bubbles are shown to bounce back, while others penetrate and burst on the interface resulting in possible small micron sized bubbles. However, small micron sized bubble may act different. It has been observed that small microbubbles can act as if they are stabilized at the interface without merging to the fluid over the interface. The dynamics of the microbubble adsorption close to an interface has yet to be well understood.In this study we used digital holography microscopy to explore detailed information on the behaviour of the air microbubble at the interface. This study investigates the position and shape of a microbubble with respect to the interface. The dynamic behavior close to the interface along with where the small microbubble is positioned near an interface will help us in understanding the probability of penetration and merging back to the fluid on top.

  16. BLOWING COSMIC BUBBLES

    NASA Technical Reports Server (NTRS)

    2002-01-01

    This NASA Hubble Space Telescope image reveals an expanding shell of glowing gas surrounding a hot, massive star in our Milky Way Galaxy. This shell is being shaped by strong stellar winds of material and radiation produced by the bright star at the left, which is 10 to 20 times more massive than our Sun. These fierce winds are sculpting the surrounding material - composed of gas and dust - into the curve-shaped bubble. Astronomers have dubbed it the Bubble Nebula (NGC 7635). The nebula is 10 light-years across, more than twice the distance from Earth to the nearest star. Only part of the bubble is visible in this image. The glowing gas in the lower right-hand corner is a dense region of material that is getting blasted by radiation from the Bubble Nebula's massive star. The radiation is eating into the gas, creating finger-like features. This interaction also heats up the gas, causing it to glow. Scientists study the Bubble Nebula to understand how hot stars interact with the surrounding material. Credit: Hubble Heritage Team (AURA/STScI/NASA)

  17. A Bubble Bursts

    NASA Technical Reports Server (NTRS)

    2005-01-01

    RCW 79 is seen in the southern Milky Way, 17,200 light-years from Earth in the constellation Centaurus. The bubble is 70-light years in diameter, and probably took about one million years to form from the radiation and winds of hot young stars.

    The balloon of gas and dust is an example of stimulated star formation. Such stars are born when the hot bubble expands into the interstellar gas and dust around it. RCW 79 has spawned at least two groups of new stars along the edge of the large bubble. Some are visible inside the small bubble in the lower left corner. Another group of baby stars appears near the opening at the top.

    NASA's Spitzer Space Telescope easily detects infrared light from the dust particles in RCW 79. The young stars within RCW 79 radiate ultraviolet light that excites molecules of dust within the bubble. This causes the dust grains to emit infrared light that is detected by Spitzer and seen here as the extended red features.

  18. Recovering chaotic properties from small data.

    PubMed

    Shao, Chenxi; Fang, Fang; Liu, Qingqing; Wang, Tingting; Wang, Binghong; Yin, Peifeng

    2014-12-01

    Physical properties are obviously essential to study a chaotic system that generates discrete-time signals, but recovering chaotic properties of a signal source from small data is a very troublesome work. Existing chaotic models are weak in dealing with such case in that most of them need big data to exploit those properties. In this paper, geometric theory is considered to solve this problem. We build a smooth trajectory from series to implicitly exhibit the chaotic properties with series-nonuniform rational B-spline (S-NURBS) modeling method, which is presented by our team to model slow-changing chaotic time series. As for the part of validation, we reveal how well our model recovers the properties from both the statistical and the chaotic aspects to confirm the effectiveness of the model. Finally a practical chaotic model is built up to recover the chaotic properties contained in the Musa standard dataset, which is used in analyzing software reliability, thereby further proves the high credibility of this model in practical time series. The effectiveness of the S-NURBS modeling leads us to believe that it is really a feasible and worthy research area to study chaotic systems from geometric perspective. For this reason, we reckon that we have opened up a new horizon for chaotic system research.

  19. Oscillatory/Chaotic Thermocapillary Flow Induced by Radiant Heating

    NASA Technical Reports Server (NTRS)

    DeWitt, Kenneth J.

    1998-01-01

    There is a continuing need to understand the fluid physics occurring under low gravity conditions in processes such as crystal growth, materials processing, and the movement of bubbles or droplets. The fluid flow in such situations is often caused by a gradient in interfacial tension. If a temperature gradient is created due to a heat source, the resulting flow is called thermocapillary flow, a special case of Marangoni Convection. In this study, an experimental investigation was conducted using silicone oil in cylindrical containers with a laser heat source at the free surface. It was desired to determine the conditions under which steady, axisymmetrical thermocapillary flow becomes unstable and oscillatory three-dimensional flow states develop. The critical Marangoni number for each observed oscillatory state was measured as a function of the container aspect ratio and the dynamic Bond number, a measure of buoyant force versus ii thermocapillary force. Various oscillatory modes were observed during three- dimensional convection, and chaotic flow was reached in one test condition. The critical Marangoni numbers are compared with those measured in previous studies, and the power spectra and phase trajectories of the instantaneous surface temperature distributions are used to characterize the routes of transitions to the chaotic flow state. Results show that only superharmonic modes appear in the routes to chaos while infinite number of subharmonic modes occur in flow transitions for pure Rayleigh convection.

  20. System-level simulation of liquid filling in microfluidic chips.

    PubMed

    Song, Hongjun; Wang, Yi; Pant, Kapil

    2011-06-01

    Liquid filling in microfluidic channels is a complex process that depends on a variety of geometric, operating, and material parameters such as microchannel geometry, flow velocity∕pressure, liquid surface tension, and contact angle of channel surface. Accurate analysis of the filling process can provide key insights into the filling time, air bubble trapping, and dead zone formation, and help evaluate trade-offs among the various design parameters and lead to optimal chip design. However, efficient modeling of liquid filling in complex microfluidic networks continues to be a significant challenge. High-fidelity computational methods, such as the volume of fluid method, are prohibitively expensive from a computational standpoint. Analytical models, on the other hand, are primarily applicable to idealized geometries and, hence, are unable to accurately capture chip level behavior of complex microfluidic systems. This paper presents a parametrized dynamic model for the system-level analysis of liquid filling in three-dimensional (3D) microfluidic networks. In our approach, a complex microfluidic network is deconstructed into a set of commonly used components, such as reservoirs, microchannels, and junctions. The components are then assembled according to their spatial layout and operating rationale to achieve a rapid system-level model. A dynamic model based on the transient momentum equation is developed to track the liquid front in the microchannels. The principle of mass conservation at the junction is used to link the fluidic parameters in the microchannels emanating from the junction. Assembly of these component models yields a set of differential and algebraic equations, which upon integration provides temporal information of the liquid filling process, particularly liquid front propagation (i.e., the arrival time). The models are used to simulate the transient liquid filling process in a variety of microfluidic constructs and in a multiplexer, representing a

  1. System-level simulation of liquid filling in microfluidic chips.

    PubMed

    Song, Hongjun; Wang, Yi; Pant, Kapil

    2011-06-01

    Liquid filling in microfluidic channels is a complex process that depends on a variety of geometric, operating, and material parameters such as microchannel geometry, flow velocity∕pressure, liquid surface tension, and contact angle of channel surface. Accurate analysis of the filling process can provide key insights into the filling time, air bubble trapping, and dead zone formation, and help evaluate trade-offs among the various design parameters and lead to optimal chip design. However, efficient modeling of liquid filling in complex microfluidic networks continues to be a significant challenge. High-fidelity computational methods, such as the volume of fluid method, are prohibitively expensive from a computational standpoint. Analytical models, on the other hand, are primarily applicable to idealized geometries and, hence, are unable to accurately capture chip level behavior of complex microfluidic systems. This paper presents a parametrized dynamic model for the system-level analysis of liquid filling in three-dimensional (3D) microfluidic networks. In our approach, a complex microfluidic network is deconstructed into a set of commonly used components, such as reservoirs, microchannels, and junctions. The components are then assembled according to their spatial layout and operating rationale to achieve a rapid system-level model. A dynamic model based on the transient momentum equation is developed to track the liquid front in the microchannels. The principle of mass conservation at the junction is used to link the fluidic parameters in the microchannels emanating from the junction. Assembly of these component models yields a set of differential and algebraic equations, which upon integration provides temporal information of the liquid filling process, particularly liquid front propagation (i.e., the arrival time). The models are used to simulate the transient liquid filling process in a variety of microfluidic constructs and in a multiplexer, representing a

  2. Chaotic attractors with separated scrolls

    NASA Astrophysics Data System (ADS)

    Bouallegue, Kais

    2015-07-01

    This paper proposes a new behavior of chaotic attractors with separated scrolls while combining Julia's process with Chua's attractor and Lorenz's attractor. The main motivation of this work is the ability to generate a set of separated scrolls with different behaviors, which in turn allows us to choose one or many scrolls combined with modulation (amplitude and frequency) for secure communication or synchronization. This set seems a new class of hyperchaos because each element of this set looks like a simple chaotic attractor with one positive Lyapunov exponent, so the cardinal of this set is greater than one. This new approach could be used to generate more general higher-dimensional hyperchaotic attractor for more potential application. Numerical simulations are given to show the effectiveness of the proposed theoretical results.

  3. Chaotic pulsations in stellar models

    SciTech Connect

    Buchler, J.R. )

    1990-12-01

    The irregular behavior of large-amplitude pulsating stars undergoing radial oscillations is examined theoretically, with a focus on hydrodynamic simulations of the W Virginis population II Cepheids (stars which show both regular and RV Tau characteristics). Sequences of models are constructed as one-parameter families (with luminosity, mass, and composition fixed and Teff as the control parameter) and analyzed to derive a systematic map of the bifurcation set; i.e., of the possible types of pulsations. The results are presented graphically, and it is shown that both cascades of period doubling (via destabilization of an overtone through a half-integer-type resonance) and tangent bifurcation are possible routes to chaos in these systems, depending on the stellar parameters. The general robustness of the chaotic behavior and the existence of a 'chaotic blue edge' in stellar-parameter space are demonstrated. 55 refs.

  4. The Chaotic Dynamics of Jamming

    NASA Astrophysics Data System (ADS)

    Egolf, David A.; Banigan, Edward J.; Illich, Matthew K.; Stace-Naughton, Derick J.

    2013-03-01

    Despite the appearance of simplicity, much of the behavior of granular materials remains mysterious. One intriguing puzzle is the dynamical mechanism underlying the ``jamming'' transition, in which disordered grains become rigid at high density. By applying nonlinear dynamical techniques to simulated 2D shear cells, we reveal the mechanisms of jamming and find they conflict with the prevailing picture of growing cooperative regions. Additionally, at the density corresponding to random close packing, we find a dynamical transition from chaotic to non-chaotic states accompanied by diverging dynamical length and time scales. Furthermore, we find that the dominant cooperative dynamical modes are strongly correlated with particle rearrangements and become increasingly unstable before stress jumps, providing a way to predict the times and locations of these earthquake-like stress-release events. This work was supported by the U.S. National Science Foundation (DMR-0094178) and Research Corporation.

  5. Chaotic attractors with separated scrolls

    SciTech Connect

    Bouallegue, Kais

    2015-07-15

    This paper proposes a new behavior of chaotic attractors with separated scrolls while combining Julia's process with Chua's attractor and Lorenz's attractor. The main motivation of this work is the ability to generate a set of separated scrolls with different behaviors, which in turn allows us to choose one or many scrolls combined with modulation (amplitude and frequency) for secure communication or synchronization. This set seems a new class of hyperchaos because each element of this set looks like a simple chaotic attractor with one positive Lyapunov exponent, so the cardinal of this set is greater than one. This new approach could be used to generate more general higher-dimensional hyperchaotic attractor for more potential application. Numerical simulations are given to show the effectiveness of the proposed theoretical results.

  6. Chaotic desynchronization of multistrain diseases

    NASA Astrophysics Data System (ADS)

    Schwartz, Ira B.; Shaw, Leah B.; Cummings, Derek A. T.; Billings, Lora; McCrary, Marie; Burke, Donald S.

    2005-12-01

    Multistrain diseases are diseases that consist of several strains, or serotypes. The serotypes may interact by antibody-dependent enhancement (ADE), in which infection with a single serotype is asymptomatic, but infection with a second serotype leads to serious illness accompanied by greater infectivity. It has been observed from serotype data of dengue hemorrhagic fever that outbreaks of the four serotypes occur asynchronously. Both autonomous and seasonally driven outbreaks were studied in a model containing ADE. For sufficiently small ADE, the number of infectives of each serotype synchronizes, with outbreaks occurring in phase. When the ADE increases past a threshold, the system becomes chaotic, and infectives of each serotype desynchronize. However, certain groupings of the primary and secondary infectives remain synchronized even in the chaotic regime.

  7. Mechanics of collapsing cavitation bubbles.

    PubMed

    van Wijngaarden, Leen

    2016-03-01

    A brief survey is given of the dynamical phenomena accompanying the collapse of cavitation bubbles. The discussion includes shock waves, microjets and the various ways in which collapsing bubbles produce damage.

  8. Multivariate bubbles and antibubbles

    NASA Astrophysics Data System (ADS)

    Fry, John

    2014-08-01

    In this paper we develop models for multivariate financial bubbles and antibubbles based on statistical physics. In particular, we extend a rich set of univariate models to higher dimensions. Changes in market regime can be explicitly shown to represent a phase transition from random to deterministic behaviour in prices. Moreover, our multivariate models are able to capture some of the contagious effects that occur during such episodes. We are able to show that declining lending quality helped fuel a bubble in the US stock market prior to 2008. Further, our approach offers interesting insights into the spatial development of UK house prices.

  9. Heated Gas Bubbles

    NASA Technical Reports Server (NTRS)

    2004-01-01

    Fluid Physics is study of the motion of fluids and the effects of such motion. When a liquid is heated from the bottom to the boiling point in Earth's microgravity, small bubbles of heated gas form near the bottom of the container and are carried to the top of the liquid by gravity-driven convective flows. In the same setup in microgravity, the lack of convection and buoyancy allows the heated gas bubbles to grow larger and remain attached to the container's bottom for a significantly longer period.

  10. Chaotic inflation and supersymmetry breaking

    SciTech Connect

    Kallosh, Renata; Linde, Andrei; Rube, Tomas; Olive, Keith A.

    2011-10-15

    We investigate the recently proposed class of chaotic inflation models in supergravity with an arbitrary inflaton potential V({phi}). These models are extended to include matter fields in the visible sector and we employ a mechanism of supersymmetry breaking based on a particular phenomenological version of the KKLT mechanism (the KL model). We describe specific features of reheating in this class of models and show how one can solve the cosmological moduli and gravitino problems in this context.

  11. PREFACE: Nano- and microfluidics Nano- and microfluidics

    NASA Astrophysics Data System (ADS)

    Jacobs, Karin

    2011-05-01

    The field of nano- and microfluidics emerged at the end of the 1990s parallel to the demand for smaller and smaller containers and channels for chemical, biochemical and medical applications such as blood and DNS analysis [1], gene sequencing or proteomics [2, 3]. Since then, new journals and conferences have been launched and meanwhile, about two decades later, a variety of microfluidic applications are on the market. Briefly, 'the small flow becomes mainstream' [4]. Nevertheless, research in nano- and microfluidics is more than downsizing the spatial dimensions. For liquids on the nanoscale, surface and interface phenomena grow in importance and may even dominate the behavior in some systems. The studies collected in this special issue all concentrate on these type of systems and were part ot the priority programme SPP1164 'Nano- and Microfluidics' of the German Science Foundation (Deutsche Forschungsgemeinschaft, DFG). The priority programme was initiated in 2002 by Hendrik Kuhlmann and myself and was launched in 2004. Friction between a moving liquid and a solid wall may, for instance, play an important role so that the usual assumption of a no-slip boundary condition is no longer valid. Likewise, the dynamic deformations of soft objects like polymers, vesicles or capsules in flow arise from the subtle interplay between the (visco-)elasticity of the object and the viscous stresses in the surrounding fluid and, potentially, the presence of structures confining the flow like channels. Consequently, new theories were developed ( see articles in this issue by Münch and Wagner, Falk and Mecke, Bonthuis et al, Finken et al, Almenar and Rauscher, Straube) and experiments were set up to unambiguously demonstrate deviations from bulk, or 'macro', behavior (see articles in this issue by Wolff et al, Vinogradova and Belyaev, Hahn et al, Seemann et al, Grüner and Huber, Müller-Buschbaum et al, Gutsche et al, Braunmüller et al, Laube et al, Brücker, Nottebrock et al

  12. Fluid Dynamics of Bubbly Liquids

    NASA Technical Reports Server (NTRS)

    Tsang, Y. H.; Koch, D. L.; Zenit, R.; Sangani, A.; Kushch, V. I.; Spelt, P. D. M.; Hoffman, M.; Nahra, H.; Fritz, C.; Dolesh, R.

    2002-01-01

    Experiments have been performed to study the average flow properties of inertially dominated bubbly liquids which may be described by a novel analysis. Bubbles with high Reynolds number and low Weber number may produce a fluid velocity disturbance that can be approximated by a potential flow. We studied the behavior of suspensions of bubbles of about 1.5 mm diameter in vertical and inclined channels. The suspension was produced using a bank of 900 glass capillaries with inner diameter of about 100 microns in a quasi-steady fashion. In addition, salt was added to the suspension to prevent bubble-bubble coalescence. As a result, a nearly monodisperse suspension of bubble was produced. By increasing the inclination angle, we were able to explore an increasing amount of shear to buoyancy motion. A pipe flow experiment with the liquid being recirculated is under construction. This will provide an even larger range of shear to buoyancy motion. We are planning a microgravity experiment in which a bubble suspension is subjected to shearing in a couette cell in the absence of a buoyancy-driven relative motion of the two phases. By employing a single-wire, hot film anemometer, we were able to obtain the liquid velocity fluctuations. The shear stress at the wall was measured using a hot film probe flush mounted on the wall. The gas volume fraction, bubble velocity, and bubble velocity fluctuations were measured using a homemade, dual impedance probe. In addition, we also employed a high-speed camera to obtain the bubble size distribution and bubble shape in a dilute suspension. A rapid decrease in bubble velocity for a dilute bubble suspension is attributed to the effects of bubble-wall collisions. The more gradual decrease of bubble velocity as gas volume fraction increases, due to subsequent hindering of bubble motion, is in qualitative agreement with the predictions of Spelt and Sangani for the effects of potential-flow bubble-bubble interactions on the mean velocity. The

  13. CHAOTIC CAPTURE OF NEPTUNE TROJANS

    SciTech Connect

    Nesvorny, David; Vokrouhlicky, David

    2009-06-15

    Neptune Trojans (NTs) are swarms of outer solar system objects that lead/trail planet Neptune during its revolutions around the Sun. Observations indicate that NTs form a thick cloud of objects with a population perhaps {approx}10 times more numerous than that of Jupiter Trojans and orbital inclinations reaching {approx}25 deg. The high inclinations of NTs are indicative of capture instead of in situ formation. Here we study a model in which NTs were captured by Neptune during planetary migration when secondary resonances associated with the mean-motion commensurabilities between Uranus and Neptune swept over Neptune's Lagrangian points. This process, known as chaotic capture, is similar to that previously proposed to explain the origin of Jupiter's Trojans. We show that chaotic capture of planetesimals from an {approx}35 Earth-mass planetesimal disk can produce a population of NTs that is at least comparable in number to that inferred from current observations. The large orbital inclinations of NTs are a natural outcome of chaotic capture. To obtain the {approx}4:1 ratio between high- and low-inclination populations suggested by observations, planetary migration into a dynamically excited planetesimal disk may be required. The required stirring could have been induced by Pluto-sized and larger objects that have formed in the disk.

  14. Modelling chaotic vibrations using NASTRAN

    NASA Technical Reports Server (NTRS)

    Sheerer, T. J.

    1993-01-01

    Due to the unavailability and, later, prohibitive cost of the computational power required, many phenomena in nonlinear dynamic systems have in the past been addressed in terms of linear systems. Linear systems respond to periodic inputs with periodic outputs, and may be characterized in the time domain or in the frequency domain as convenient. Reduction to the frequency domain is frequently desireable to reduce the amount of computation required for solution. Nonlinear systems are only soluble in the time domain, and may exhibit a time history which is extremely sensitive to initial conditions. Such systems are termed chaotic. Dynamic buckling, aeroelasticity, fatigue analysis, control systems and electromechanical actuators are among the areas where chaotic vibrations have been observed. Direct transient analysis over a long time period presents a ready means of simulating the behavior of self-excited or externally excited nonlinear systems for a range of experimental parameters, either to characterize chaotic behavior for development of load spectra, or to define its envelope and preclude its occurrence.

  15. Modelling chaotic vibrations using NASTRAN

    NASA Astrophysics Data System (ADS)

    Sheerer, T. J.

    1993-09-01

    Due to the unavailability and, later, prohibitive cost of the computational power required, many phenomena in nonlinear dynamic systems have in the past been addressed in terms of linear systems. Linear systems respond to periodic inputs with periodic outputs, and may be characterized in the time domain or in the frequency domain as convenient. Reduction to the frequency domain is frequently desireable to reduce the amount of computation required for solution. Nonlinear systems are only soluble in the time domain, and may exhibit a time history which is extremely sensitive to initial conditions. Such systems are termed chaotic. Dynamic buckling, aeroelasticity, fatigue analysis, control systems and electromechanical actuators are among the areas where chaotic vibrations have been observed. Direct transient analysis over a long time period presents a ready means of simulating the behavior of self-excited or externally excited nonlinear systems for a range of experimental parameters, either to characterize chaotic behavior for development of load spectra, or to define its envelope and preclude its occurrence.

  16. Chaotic pendulum: The complete attractor

    NASA Astrophysics Data System (ADS)

    DeSerio, Robert

    2003-03-01

    A commercial chaotic pendulum is modified to study nonlinear dynamics, including the determination of Poincaré sections, fractal dimensions, and Lyapunov exponents. The apparatus is driven by a simple oscillating mechanism powered by a 200 pulse per revolution stepper motor running at constant angular velocity. A computer interface generates the uniform pulse train needed to run the stepper motor and, with each pulse, reads a rotary encoder attached to the pendulum axle. Ten million readings from overnight runs of 50 000 drive cycles were smoothed and differentiated to obtain the pendulum angle θ and the angular velocity ω at each pulse of the drive. A plot of the 50 000 (θ,ω) phase points corresponding to one phase of the drive system produces a single Poincaré section. Thus, 200 Poincaré sections are experimentally available, one at each step of the drive. Viewed separately, any one of them strikingly illustrates the fractal geometry of the underlying chaotic attractor. Viewed sequentially in a repeating loop, they demonstrate the stretching and folding of phase point density typical of chaotic dynamics. Results for four pendulum damping conditions are presented and compared.

  17. Characterizing chaotic melodies in automatic music composition.

    PubMed

    Coca, Andrés E; Tost, Gerard O; Zhao, Liang

    2010-09-01

    In this paper, we initially present an algorithm for automatic composition of melodies using chaotic dynamical systems. Afterward, we characterize chaotic music in a comprehensive way as comprising three perspectives: musical discrimination, dynamical influence on musical features, and musical perception. With respect to the first perspective, the coherence between generated chaotic melodies (continuous as well as discrete chaotic melodies) and a set of classical reference melodies is characterized by statistical descriptors and melodic measures. The significant differences among the three types of melodies are determined by discriminant analysis. Regarding the second perspective, the influence of dynamical features of chaotic attractors, e.g., Lyapunov exponent, Hurst coefficient, and correlation dimension, on melodic features is determined by canonical correlation analysis. The last perspective is related to perception of originality, complexity, and degree of melodiousness (Euler's gradus suavitatis) of chaotic and classical melodies by nonparametric statistical tests.

  18. Characterizing chaotic melodies in automatic music composition

    NASA Astrophysics Data System (ADS)

    Coca, Andrés E.; Tost, Gerard O.; Zhao, Liang

    2010-09-01

    In this paper, we initially present an algorithm for automatic composition of melodies using chaotic dynamical systems. Afterward, we characterize chaotic music in a comprehensive way as comprising three perspectives: musical discrimination, dynamical influence on musical features, and musical perception. With respect to the first perspective, the coherence between generated chaotic melodies (continuous as well as discrete chaotic melodies) and a set of classical reference melodies is characterized by statistical descriptors and melodic measures. The significant differences among the three types of melodies are determined by discriminant analysis. Regarding the second perspective, the influence of dynamical features of chaotic attractors, e.g., Lyapunov exponent, Hurst coefficient, and correlation dimension, on melodic features is determined by canonical correlation analysis. The last perspective is related to perception of originality, complexity, and degree of melodiousness (Euler's gradus suavitatis) of chaotic and classical melodies by nonparametric statistical tests.

  19. Droplet microfluidics based microseparation systems.

    PubMed

    Xiao, Zhiliang; Niu, Menglei; Zhang, Bo

    2012-06-01

    Lab on a chip (LOC) technology is a promising miniaturization approach. The feature that it significantly reduced sample consumption makes great sense in analytical and bioanalytical chemistry. Since the start of LOC technology, much attention has been focused on continuous flow microfluidic systems. At the turn of the century, droplet microfluidics, which was also termed segmented flow microfluidics, was introduced. Droplet microfluidics employs two immiscible phases to form discrete droplets, which are ideal vessels with confined volume, restricted dispersion, limited cross-contamination, and high surface area. Due to these unique features, droplet microfluidics proves to be a versatile tool in microscale sample handling. This article reviews the utility of droplet microfluidics in microanalytical systems with an emphasize on separation science, including sample encapsulation at ultra-small volume, compartmentalization of separation bands, isolation of droplet contents, and related detection techniques.

  20. Cohesion of Bubbles in Foam

    ERIC Educational Resources Information Center

    Ross, Sydney

    1978-01-01

    The free-energy change, or binding energy, of an idealized bubble cluster is calculated on the basis of one mole of gas, and on the basis of a single bubble going from sphere to polyhedron. Some new relations of bubble geometry are developed in the course of the calculation. (BB)

  1. The Early Years: Blowing Bubbles

    ERIC Educational Resources Information Center

    Ashbrook, Peggy

    2016-01-01

    Blowing bubbles is not only a favorite summer activity for young children. Studying bubbles that are grouped together, or "foam," is fun for children and fascinating to many real-world scientists. Foam is widely used--from the bedroom (mattresses) to outer space (insulating panels on spacecraft). Bubble foam can provide children a…

  2. Intermittent chaotic chimeras for coupled rotators.

    PubMed

    Olmi, Simona; Martens, Erik A; Thutupalli, Shashi; Torcini, Alessandro

    2015-09-01

    Two symmetrically coupled populations of N oscillators with inertia m display chaotic solutions with broken symmetry similar to experimental observations with mechanical pendulums. In particular, we report evidence of intermittent chaotic chimeras, where one population is synchronized and the other jumps erratically between laminar and turbulent phases. These states have finite lifetimes diverging as a power law with N and m. Lyapunov analyses reveal chaotic properties in quantitative agreement with theoretical predictions for globally coupled dissipative systems.

  3. Chaotic evolution of the solar system

    NASA Technical Reports Server (NTRS)

    Sussman, Gerald J.; Wisdom, Jack

    1992-01-01

    The evolution of the entire planetary system has been numerically integrated for a time span of nearly 100 million years. This calculation confirms that the evolution of the solar system as a whole is chaotic, with a time scale of exponential divergence of about 4 million years. Additional numerical experiments indicate that the Jovian planet subsystem is chaotic, although some small variations in the model can yield quasi-periodic motion. The motion of Pluto is independently and robustly chaotic.

  4. TS fuzzy realization of chaotic Lü system

    NASA Astrophysics Data System (ADS)

    Li, Dequan

    2006-07-01

    The Lü attractor is a new chaotic attractor, which connects the Lorenz attractor and the Chen attractor and represents the transition from one to the other. The Letter presents a hybrid TS fuzzy modeling approach for the newly coined chaotic Lü system. Then the abundant and fundamental dynamical behaviors of the chaotic Lü system are completely and comprehensive investigated based on this novel hybrid TS fuzzy model.

  5. Microfluidic Chips for Semen Analysis

    PubMed Central

    Segerink, L.I.; Sprenkels, A.J.; Oosterhuis, G.J.E.; Vermes, I.; van den Berg, A.

    2012-01-01

    The gold standard of semen analysis is still an manual method, which is time-consuming, labour intensive and needs thorough quality control. Microfluidics can also offer advantages for this application. Therefore a first step in the development of a microfluidic chip has been made, which enables the man the semen analysis at home. In this article recent efforts to determine the concentration and motility using a microfluidic chip are summarized.

  6. Microfluidic device, and related methods

    NASA Technical Reports Server (NTRS)

    Wong, Eric W. (Inventor)

    2010-01-01

    A method of making a microfluidic device is provided. The method features patterning a permeable wall on a substrate, and surrounding the permeable wall with a solid, non-permeable boundary structure to establish a microfluidic channel having a cross-sectional dimension less than 5,000 microns and a cross-sectional area at least partially filled with the permeable wall so that fluid flowing through the microfluidic channel at least partially passes through the permeable wall.

  7. PDMS free-flow electrophoresis chips with integrated partitioning bars for bubble segregation.

    PubMed

    Köhler, Stefan; Weilbeer, Claudia; Howitz, Steffen; Becker, Holger; Beushausen, Volker; Belder, Detlev

    2011-01-21

    In this work, a microfluidic free-flow electrophoresis device with a novel approach for preventing gas bubbles from entering the separation area is presented. This is achieved by integrating partitioning bars to reduce the channel depth between electrode channels and separation chamber in order to obtain electrical contact and simultaneously prevent bubbles from entering the separation area. The three-layer sandwich chip features a reusable carrier plate with integrated ports for fluidic connection combined with a softlithographically cast microfluidic PDMS layer and a sealing glass slide. This design allows for a straightforward and rapid chip prototyping process. The performance of the device is demonstrated by free-flow zone electrophoretic separations of fluorescent dye mixtures as well as by the separation of labeled amines and amino acids with separation voltages up to 297 V.

  8. Experimental observation of transition from chaotic bursting to chaotic spiking in a neural pacemaker

    NASA Astrophysics Data System (ADS)

    Gu, Huaguang

    2013-06-01

    The transition from chaotic bursting to chaotic spiking has been simulated and analyzed in theoretical neuronal models. In the present study, we report experimental observations in a neural pacemaker of a transition from chaotic bursting to chaotic spiking within a bifurcation scenario from period-1 bursting to period-1 spiking. This was induced by adjusting extracellular calcium or potassium concentrations. The bifurcation scenario began from period-doubling bifurcations or period-adding sequences of bursting pattern. This chaotic bursting is characterized by alternations between multiple continuous spikes and a long duration of quiescence, whereas chaotic spiking is comprised of fast, continuous spikes without periods of quiescence. Chaotic bursting changed to chaotic spiking as long interspike intervals (ISIs) of quiescence disappeared within bursting patterns, drastically decreasing both ISIs and the magnitude of the chaotic attractors. Deterministic structures of the chaotic bursting and spiking patterns are also identified by a short-term prediction. The experimental observations, which agree with published findings in theoretical neuronal models, demonstrate the existence and reveal the dynamics of a neuronal transition from chaotic bursting to chaotic spiking in the nervous system.

  9. Experimental observation of transition from chaotic bursting to chaotic spiking in a neural pacemaker.

    PubMed

    Gu, Huaguang

    2013-06-01

    The transition from chaotic bursting to chaotic spiking has been simulated and analyzed in theoretical neuronal models. In the present study, we report experimental observations in a neural pacemaker of a transition from chaotic bursting to chaotic spiking within a bifurcation scenario from period-1 bursting to period-1 spiking. This was induced by adjusting extracellular calcium or potassium concentrations. The bifurcation scenario began from period-doubling bifurcations or period-adding sequences of bursting pattern. This chaotic bursting is characterized by alternations between multiple continuous spikes and a long duration of quiescence, whereas chaotic spiking is comprised of fast, continuous spikes without periods of quiescence. Chaotic bursting changed to chaotic spiking as long interspike intervals (ISIs) of quiescence disappeared within bursting patterns, drastically decreasing both ISIs and the magnitude of the chaotic attractors. Deterministic structures of the chaotic bursting and spiking patterns are also identified by a short-term prediction. The experimental observations, which agree with published findings in theoretical neuronal models, demonstrate the existence and reveal the dynamics of a neuronal transition from chaotic bursting to chaotic spiking in the nervous system.

  10. Information encoder/decoder using chaotic systems

    DOEpatents

    Miller, Samuel Lee; Miller, William Michael; McWhorter, Paul Jackson

    1997-01-01

    The present invention discloses a chaotic system-based information encoder and decoder that operates according to a relationship defining a chaotic system. Encoder input signals modify the dynamics of the chaotic system comprising the encoder. The modifications result in chaotic, encoder output signals that contain the encoder input signals encoded within them. The encoder output signals are then capable of secure transmissions using conventional transmission techniques. A decoder receives the encoder output signals (i.e., decoder input signals) and inverts the dynamics of the encoding system to directly reconstruct the original encoder input signals.

  11. Information encoder/decoder using chaotic systems

    DOEpatents

    Miller, S.L.; Miller, W.M.; McWhorter, P.J.

    1997-10-21

    The present invention discloses a chaotic system-based information encoder and decoder that operates according to a relationship defining a chaotic system. Encoder input signals modify the dynamics of the chaotic system comprising the encoder. The modifications result in chaotic, encoder output signals that contain the encoder input signals encoded within them. The encoder output signals are then capable of secure transmissions using conventional transmission techniques. A decoder receives the encoder output signals (i.e., decoder input signals) and inverts the dynamics of the encoding system to directly reconstruct the original encoder input signals. 32 figs.

  12. Oscillations of soap bubbles

    NASA Astrophysics Data System (ADS)

    Kornek, U.; Müller, F.; Harth, K.; Hahn, A.; Ganesan, S.; Tobiska, L.; Stannarius, R.

    2010-07-01

    Oscillations of droplets or bubbles of a confined fluid in a fluid environment are found in various situations in everyday life, in technological processing and in natural phenomena on different length scales. Air bubbles in liquids or liquid droplets in air are well-known examples. Soap bubbles represent a particularly simple, beautiful and attractive system to study the dynamics of a closed gas volume embedded in the same or a different gas. Their dynamics is governed by the densities and viscosities of the gases and by the film tension. Dynamic equations describing their oscillations under simplifying assumptions have been well known since the beginning of the 20th century. Both analytical description and numerical modeling have made considerable progress since then, but quantitative experiments have been lacking so far. On the other hand, a soap bubble represents an easily manageable paradigm for the study of oscillations of fluid spheres. We use a technique to create axisymmetric initial non-equilibrium states, and we observe damped oscillations into equilibrium by means of a fast video camera. Symmetries of the oscillations, frequencies and damping rates of the eigenmodes as well as the coupling of modes are analyzed. They are compared to analytical models from the literature and to numerical calculations from the literature and this work.

  13. Bubble fusion: Preliminary estimates

    SciTech Connect

    Krakowski, R.A.

    1995-02-01

    The collapse of a gas-filled bubble in disequilibrium (i.e., internal pressure {much_lt} external pressure) can occur with a significant focusing of energy onto the entrapped gas in the form of pressure-volume work and/or acoustical shocks; the resulting heating can be sufficient to cause ionization and the emission of atomic radiations. The suggestion that extreme conditions necessary for thermonuclear fusion to occur may be possible has been examined parametrically in terms of the ratio of initial bubble pressure relative to that required for equilibrium. In this sense, the disequilibrium bubble is viewed as a three-dimensional ``sling shot`` that is ``loaded`` to an extent allowed by the maximum level of disequilibrium that can stably be achieved. Values of this disequilibrium ratio in the range 10{sup {minus}5}--10{sup {minus}6} are predicted by an idealized bubble-dynamics model as necessary to achieve conditions where nuclear fusion of deuterium-tritium might be observed. Harmonic and aharmonic pressurizations/decompressions are examined as means to achieve the required levels of disequilibrium required to create fusion conditions. A number of phenomena not included in the analysis reported herein could enhance or reduce the small levels of nuclear fusions predicted.

  14. The Liberal Arts Bubble

    ERIC Educational Resources Information Center

    Agresto, John

    2011-01-01

    The author expresses his doubt that the general higher education bubble will burst anytime soon. Although tuition, student housing, and book costs have all increased substantially, he believes it is still likely that the federal government will continue to pour billions into higher education, largely because Americans have been persuaded that it…

  15. Double Bubble? No Trouble!

    ERIC Educational Resources Information Center

    Shaw, Mike I.; Smith, Greg F.

    1995-01-01

    Describes a soap-solution activity involving formation of bubbles encasing the students that requires only readily available materials and can be adapted easily for use with various grade levels. Discusses student learning outcomes including qualitative and quantitative observations and the concept of surface tension. (JRH)

  16. The Microfluidic Jukebox

    PubMed Central

    Tan, Say Hwa; Maes, Florine; Semin, Benoît; Vrignon, Jérémy; Baret, Jean-Christophe

    2014-01-01

    Music is a form of art interweaving people of all walks of life. Through subtle changes in frequencies, a succession of musical notes forms a melody which is capable of mesmerizing the minds of people. With the advances in technology, we are now able to generate music electronically without relying solely on physical instruments. Here, we demonstrate a musical interpretation of droplet-based microfluidics as a form of novel electronic musical instruments. Using the interplay of electric field and hydrodynamics in microfluidic devices, well controlled frequency patterns corresponding to musical tracks are generated in real time. This high-speed modulation of droplet frequency (and therefore of droplet sizes) may also provide solutions that reconciles high-throughput droplet production and the control of individual droplet at production which is needed for many biochemical or material synthesis applications. PMID:24781785

  17. The Microfluidic Jukebox

    NASA Astrophysics Data System (ADS)

    Tan, Say Hwa; Maes, Florine; Semin, Benoît; Vrignon, Jérémy; Baret, Jean-Christophe

    2014-04-01

    Music is a form of art interweaving people of all walks of life. Through subtle changes in frequencies, a succession of musical notes forms a melody which is capable of mesmerizing the minds of people. With the advances in technology, we are now able to generate music electronically without relying solely on physical instruments. Here, we demonstrate a musical interpretation of droplet-based microfluidics as a form of novel electronic musical instruments. Using the interplay of electric field and hydrodynamics in microfluidic devices, well controlled frequency patterns corresponding to musical tracks are generated in real time. This high-speed modulation of droplet frequency (and therefore of droplet sizes) may also provide solutions that reconciles high-throughput droplet production and the control of individual droplet at production which is needed for many biochemical or material synthesis applications.

  18. Surface Acoustic Wave Microfluidics

    NASA Astrophysics Data System (ADS)

    Yeo, Leslie Y.; Friend, James R.

    2014-01-01

    Fluid manipulations at the microscale and beyond are powerfully enabled through the use of 10-1,000-MHz acoustic waves. A superior alternative in many cases to other microfluidic actuation techniques, such high-frequency acoustics is almost universally produced by surface acoustic wave devices that employ electromechanical transduction in wafer-scale or thin-film piezoelectric media to generate the kinetic energy needed to transport and manipulate fluids placed in adjacent microfluidic structures. These waves are responsible for a diverse range of complex fluid transport phenomena - from interfacial fluid vibration and drop and confined fluid transport to jetting and atomization - underlying a flourishing research literature spanning fundamental fluid physics to chip-scale engineering applications. We highlight some of this literature to provide the reader with a historical basis, routes for more detailed study, and an impression of the field's future directions.

  19. Microfluidic colloid filtration

    PubMed Central

    Linkhorst, John; Beckmann, Torsten; Go, Dennis; Kuehne, Alexander J. C.; Wessling, Matthias

    2016-01-01

    Filtration of natural and colloidal matter is an essential process in today’s water treatment processes. The colloidal matter is retained with the help of micro- and nanoporous synthetic membranes. Colloids are retained in a “cake layer” – often coined fouling layer. Membrane fouling is the most substantial problem in membrane filtration: colloidal and natural matter build-up leads to an increasing resistance and thus decreasing water transport rate through the membrane. Theoretical models exist to describe macroscopically the hydrodynamic resistance of such transport and rejection phenomena; however, visualization of the various phenomena occurring during colloid retention is extremely demanding. Here we present a microfluidics based methodology to follow filter cake build up as well as transport phenomena occuring inside of the fouling layer. The microfluidic colloidal filtration methodology enables the study of complex colloidal jamming, crystallization and melting processes as well as translocation at the single particle level. PMID:26927706

  20. Microfluidic redox battery.

    PubMed

    Lee, Jin Wook; Goulet, Marc-Antoni; Kjeang, Erik

    2013-07-01

    A miniaturized microfluidic battery is proposed, which is the first membraneless redox battery demonstrated to date. This unique concept capitalizes on dual-pass flow-through porous electrodes combined with stratified, co-laminar flow to generate electrical power on-chip. The fluidic design is symmetric to allow for both charging and discharging operations in forward, reverse, and recirculation modes. The proof-of-concept device fabricated using low-cost materials integrated in a microfluidic chip is shown to produce competitive power levels when operated on a vanadium redox electrolyte. A complete charge/discharge cycle is performed to demonstrate its operation as a rechargeable battery, which is an important step towards providing sustainable power to lab-on-a-chip and microelectronic applications. PMID:23712370

  1. Microfluidic channel fabrication method

    DOEpatents

    Arnold, Don W.; Schoeniger, Joseph S.; Cardinale, Gregory F.

    2001-01-01

    A new channel structure for microfluidic systems and process for fabricating this structure. In contrast to the conventional practice of fabricating fluid channels as trenches or grooves in a substrate, fluid channels are fabricated as thin walled raised structures on a substrate. Microfluidic devices produced in accordance with the invention are a hybrid assembly generally consisting of three layers: 1) a substrate that can or cannot be an electrical insulator; 2) a middle layer, that is an electrically conducting material and preferably silicon, forms the channel walls whose height defines the channel height, joined to and extending from the substrate; and 3) a top layer, joined to the top of the channels, that forms a cover for the channels. The channels can be defined by photolithographic techniques and are produced by etching away the material around the channel walls.

  2. Microfluidic colloid filtration

    NASA Astrophysics Data System (ADS)

    Linkhorst, John; Beckmann, Torsten; Go, Dennis; Kuehne, Alexander J. C.; Wessling, Matthias

    2016-03-01

    Filtration of natural and colloidal matter is an essential process in today’s water treatment processes. The colloidal matter is retained with the help of micro- and nanoporous synthetic membranes. Colloids are retained in a “cake layer” – often coined fouling layer. Membrane fouling is the most substantial problem in membrane filtration: colloidal and natural matter build-up leads to an increasing resistance and thus decreasing water transport rate through the membrane. Theoretical models exist to describe macroscopically the hydrodynamic resistance of such transport and rejection phenomena; however, visualization of the various phenomena occurring during colloid retention is extremely demanding. Here we present a microfluidics based methodology to follow filter cake build up as well as transport phenomena occuring inside of the fouling layer. The microfluidic colloidal filtration methodology enables the study of complex colloidal jamming, crystallization and melting processes as well as translocation at the single particle level.

  3. Microfluidic redox battery.

    PubMed

    Lee, Jin Wook; Goulet, Marc-Antoni; Kjeang, Erik

    2013-07-01

    A miniaturized microfluidic battery is proposed, which is the first membraneless redox battery demonstrated to date. This unique concept capitalizes on dual-pass flow-through porous electrodes combined with stratified, co-laminar flow to generate electrical power on-chip. The fluidic design is symmetric to allow for both charging and discharging operations in forward, reverse, and recirculation modes. The proof-of-concept device fabricated using low-cost materials integrated in a microfluidic chip is shown to produce competitive power levels when operated on a vanadium redox electrolyte. A complete charge/discharge cycle is performed to demonstrate its operation as a rechargeable battery, which is an important step towards providing sustainable power to lab-on-a-chip and microelectronic applications.

  4. Microfluidic colloid filtration.

    PubMed

    Linkhorst, John; Beckmann, Torsten; Go, Dennis; Kuehne, Alexander J C; Wessling, Matthias

    2016-01-01

    Filtration of natural and colloidal matter is an essential process in today's water treatment processes. The colloidal matter is retained with the help of micro- and nanoporous synthetic membranes. Colloids are retained in a "cake layer"--often coined fouling layer. Membrane fouling is the most substantial problem in membrane filtration: colloidal and natural matter build-up leads to an increasing resistance and thus decreasing water transport rate through the membrane. Theoretical models exist to describe macroscopically the hydrodynamic resistance of such transport and rejection phenomena; however, visualization of the various phenomena occurring during colloid retention is extremely demanding. Here we present a microfluidics based methodology to follow filter cake build up as well as transport phenomena occuring inside of the fouling layer. The microfluidic colloidal filtration methodology enables the study of complex colloidal jamming, crystallization and melting processes as well as translocation at the single particle level. PMID:26927706

  5. Bubbly Little Star

    NASA Technical Reports Server (NTRS)

    2007-01-01

    In this processed Spitzer Space Telescope image, baby star HH 46/47 can be seen blowing two massive 'bubbles.' The star is 1,140 light-years away from Earth.

    The infant star can be seen as a white spot toward the center of the Spitzer image. The two bubbles are shown as hollow elliptical shells of bluish-green material extending from the star. Wisps of green in the image reveal warm molecular hydrogen gas, while the bluish tints are formed by starlight scattered by surrounding dust.

    These bubbles formed when powerful jets of gas, traveling at 200 to 300 kilometers per second, or about 120 to 190 miles per second, smashed into the cosmic cloud of gas and dust that surrounds HH 46/47. The red specks at the end of each bubble show the presence of hot sulfur and iron gas where the star's narrow jets are currently crashing head-on into the cosmic cloud's gas and dust material.

    Whenever astronomers observe a star, or snap a stellar portrait, through the lens of any telescope, they know that what they are seeing is slightly blurred. To clear up the blurring in Spitzer images, astronomers at the Jet Propulsion Laboratory developed an image processing technique for Spitzer called Hi-Res deconvolution.

    This process reduces blurring and makes the image sharper and cleaner, enabling astronomers to see the emissions around forming stars in greater detail. When scientists applied this image processing technique to the Spitzer image of HH 46/47, they were able to see winds from the star and jets of gas that are carving the celestial bubbles.

    This infrared image is a three-color composite, with data at 3.6 microns represented in blue, 4.5 and 5.8 microns shown in green, and 24 microns represented as red.

  6. AC magnetohydrodynamic microfluidic switch

    SciTech Connect

    Lemoff, A V; Lee, A P

    2000-03-02

    A microfluidic switch has been demonstrated using an AC Magnetohydrodynamic (MHD) pumping mechanism in which the Lorentz force is used to pump an electrolytic solution. By integrating two AC MHD pumps into different arms of a Y-shaped fluidic circuit, flow can be switched between the two arms. This type of switch can be used to produce complex fluidic routing, which may have multiple applications in {micro}TAS.

  7. Ultrafast microfluidics using surface acoustic waves

    PubMed Central

    Yeo, Leslie Y.; Friend, James R.

    2009-01-01

    We demonstrate that surface acoustic waves (SAWs), nanometer amplitude Rayleigh waves driven at megahertz order frequencies propagating on the surface of a piezoelectric substrate, offer a powerful method for driving a host of extremely fast microfluidic actuation and micro∕bioparticle manipulation schemes. We show that sessile drops can be translated rapidly on planar substrates or fluid can be pumped through microchannels at 1–10 cm∕s velocities, which are typically one to two orders quicker than that afforded by current microfluidic technologies. Through symmetry-breaking, azimuthal recirculation can be induced within the drop to drive strong inertial microcentrifugation for micromixing and particle concentration or separation. Similar micromixing strategies can be induced in the same microchannel in which fluid is pumped with the SAW by merely changing the SAW frequency to rapidly switch the uniform through-flow into a chaotic oscillatory flow by exploiting superpositioning of the irradiated sound waves from the sidewalls of the microchannel. If the flow is sufficiently quiescent, the nodes of the transverse standing wave that arises across the microchannel also allow for particle aggregation, and hence, sorting on nodal lines. In addition, the SAW also facilitates other microfluidic capabilities. For example, capillary waves excited at the free surface of a sessile drop by the SAW underneath it can be exploited for micro∕nanoparticle collection and sorting at nodal points or lines at low powers. At higher powers, the large accelerations off the substrate surface as the SAW propagates across drives rapid destabilization of the drop free surface giving rise to inertial liquid jets that persist over 1–2 cm in length or atomization of the entire drop to produce 1–10 μm monodispersed aerosol droplets, which can be exploited for ink-jet printing, mass spectrometry interfacing, or pulmonary drug delivery. The atomization of polymer∕protein solutions

  8. High-pressure microfluidics

    NASA Astrophysics Data System (ADS)

    Hjort, K.

    2015-03-01

    When using appropriate materials and microfabrication techniques, with the small dimensions the mechanical stability of microstructured devices allows for processes at high pressures without loss in safety. The largest area of applications has been demonstrated in green chemistry and bioprocesses, where extraction, synthesis and analyses often excel at high densities and high temperatures. This is accessible through high pressures. Capillary chemistry has been used since long but, just like in low-pressure applications, there are several potential advantages in using microfluidic platforms, e.g., planar isothermal set-ups, large local variations in geometries, dense form factors, small dead volumes and precisely positioned microstructures for control of reactions, catalysis, mixing and separation. Other potential applications are in, e.g., microhydraulics, exploration, gas driven vehicles, and high-pressure science. From a review of the state-of-art and frontiers of high pressure microfluidics, the focus will be on different solutions demonstrated for microfluidic handling at high pressures and challenges that remain.

  9. Multilayer microfluidic PEGDA hydrogels.

    PubMed

    Cuchiara, Michael P; Allen, Alicia C B; Chen, Theodore M; Miller, Jordan S; West, Jennifer L

    2010-07-01

    Development of robust 3D tissue analogs in vitro is limited by passive, diffusional mass transport. Perfused microfluidic tissue engineering scaffolds hold the promise to improve mass transport limitations and promote the development of complex, metabolically dense, and clinically relevant tissues. We report a simple and robust multilayer replica molding technique in which poly(dimethylsiloxane) (PDMS) and poly(ethylene glycol) diacrylate (PEGDA) are serially replica molded to develop microfluidic PEGDA hydrogel networks embedded within independently fabricated PDMS housings. We demonstrate the ability to control solute-scaffold effective diffusivity as a function of solute molecular weight and hydrogel concentration. Within cell laden microfluidic hydrogels, we demonstrate increased cellular viability in perfused hydrogel systems compared to static controls. We observed a significant increase in cell viability at all time points greater than zero at distances up to 1 mm from the perfused channel. Knowledge of spatiotemporal mass transport and cell viability gradients provides useful engineering design parameters necessary to maximize overall scaffold viability and metabolic density. This work has applications in the development of hydrogels as in vitro diagnostics and ultimately as regenerative medicine based therapeutics.

  10. Ring Bubbles of Dolphins

    NASA Technical Reports Server (NTRS)

    Shariff, Karim; Marten, Ken; Psarakos, Suchi; White, Don J.; Merriam, Marshal (Technical Monitor)

    1996-01-01

    The article discusses how dolphins create and play with three types of air-filled vortices. The underlying physics is discussed. Photographs and sketches illustrating the dolphin's actions and physics are presented. The dolphins engage in this behavior on their own initiative without food reward. These behaviors are done repeatedly and with singleminded effort. The first type is the ejection of bubbles which, after some practice on the part of the dolphin, turn into toroidal vortex ring bubbles by the mechanism of baroclinic torque. These bubbles grow in radius and become thinner as they rise vertically to the surface. One dolphin would blow two in succession and guide them to fuse into one. Physicists call this a vortex reconnection. In the second type, the dolphins first create an invisible vortex ring in the water by swimming on their side and waving their tail fin (also called flukes) vigorously. This vortex ring travels horizontally in the water. The dolphin then turns around, finds the vortex and injects a stream of air into it from its blowhole. The air "fills-out" the core of the vortex ring. Often, the dolphin would knock-off a smaller ring bubble from the larger ring (this also involves vortex reconnection) and steer the smaller ring around the tank. One other dolphin employed a few other techniques for planting air into the fluke vortex. One technique included standing vertically in the water with tail-up, head-down and tail piercing the free surface. As the fluke is waved to create the vortex ring, air is entrained from above the surface. Another technique was gulping air in the mouth, diving down, releasing air bubbles from the mouth and curling them into a ring when they rose to the level of the fluke. In the third type, demonstrated by only one dolphin, the longitudinal vortex created by the dorsal fin on the back is used to produce 10-15 foot long helical bubbles. In one technique she swims in a curved path. This creates a dorsal fin vortex since

  11. Microfluidic Devices for Behavioral Analysis, Microscopy, and Neuronal Imaging in Caenorhabditis elegans.

    PubMed

    Lagoy, Ross C; Albrecht, Dirk R

    2015-01-01

    Microfluidic devices offer several advantages for C. elegans research, particularly for presenting precise physical and chemical environments, immobilizing animals during imaging, quantifying behavior, and automating screens. However, challenges to their widespread adoption in the field include increased complexity over conventional methods, operational problems (such as clogging, leaks, and bubbles), difficulty in obtaining or fabricating devices, and the need to characterize biological results obtained from new assay formats. Here we describe the preparation and operation of simple, reusable microfluidic devices for quantifying behavioral responses to chemical patterns, and single-use devices to arrange animals for time-lapse microscopy and to measure neuronal activity. We focus on details that eliminate or reduce the frustrations commonly experienced by new users of microfluidic devices. PMID:26423974

  12. Driving trajectories in chaotic scattering.

    PubMed

    Macau, Elbert E N; Caldas, Iberê L

    2002-02-01

    In this work we introduce a general approach for targeting in chaotic scattering that can be used to find a transfer trajectory between any two points located inside the scattering region. We show that this method can be used in association with a control of chaos strategy to drive around and keep a particle inside the scattering region. As an illustration of how powerful this approach is, we use it in a case of practical interest in celestial mechanics in which it is desired to control the evolution of two satellites that evolve around a large central body. PMID:11863640

  13. Driving trajectories in chaotic scattering.

    PubMed

    Macau, Elbert E N; Caldas, Iberê L

    2002-02-01

    In this work we introduce a general approach for targeting in chaotic scattering that can be used to find a transfer trajectory between any two points located inside the scattering region. We show that this method can be used in association with a control of chaos strategy to drive around and keep a particle inside the scattering region. As an illustration of how powerful this approach is, we use it in a case of practical interest in celestial mechanics in which it is desired to control the evolution of two satellites that evolve around a large central body.

  14. Chaotic dynamics from interspike intervals.

    PubMed

    Pavlov, A N; Sosnovtseva, O V; Mosekilde, E; Anishchenko, V S

    2001-03-01

    Considering two different mathematical models describing chaotic spiking phenomena, namely, an integrate-and-fire and a threshold-crossing model, we discuss the problem of extracting dynamics from interspike intervals (ISIs) and show that the possibilities of computing the largest Lyapunov exponent (LE) from point processes differ between the two models. We also consider the problem of estimating the second LE and the possibility to diagnose hyperchaotic behavior by processing spike trains. Since the second exponent is quite sensitive to the structure of the ISI series, we investigate the problem of its computation. PMID:11308739

  15. Chaotic dynamics from interspike intervals

    NASA Astrophysics Data System (ADS)

    Pavlov, Alexey N.; Sosnovtseva, Olga V.; Mosekilde, Erik; Anishchenko, Vadim S.

    2001-03-01

    Considering two different mathematical models describing chaotic spiking phenomena, namely, an integrate-and-fire and a threshold-crossing model, we discuss the problem of extracting dynamics from interspike intervals (ISIs) and show that the possibilities of computing the largest Lyapunov exponent (LE) from point processes differ between the two models. We also consider the problem of estimating the second LE and the possibility to diagnose hyperchaotic behavior by processing spike trains. Since the second exponent is quite sensitive to the structure of the ISI series, we investigate the problem of its computation.

  16. Monolithic microfluidic concentrators and mixers

    DOEpatents

    Frechet, Jean M.; Svec, Frantisek; Yu, Cong; Rohr, Thomas

    2005-05-03

    Microfluidic devices comprising porous monolithic polymer for concentration, extraction or mixing of fluids. A method for in situ preparation of monolithic polymers by in situ initiated polymerization of polymer precursors within microchannels of a microfluidic device and their use for solid phase extraction (SPE), preconcentration, concentration and mixing.

  17. Microfluidic Stamping on Sheath Flow.

    PubMed

    Yoon, Dong Hyun; Tanaka, Daiki; Sekiguchi, Tetsushi; Shoji, Shuichi

    2016-06-01

    A microfluidic stamping method to form functional shapes on a cross section in fiber-shaped flow is proposed. Microfluidic stamping and overstamping allow various cross sectional shapes on the 3D flow. The shapes can be controlled by a change in combination of structures and fluidic conditions which correspond to stamp type and stamping force. PMID:27149895

  18. Centrifugal microfluidics for biomedical applications.

    PubMed

    Gorkin, Robert; Park, Jiwoon; Siegrist, Jonathan; Amasia, Mary; Lee, Beom Seok; Park, Jong-Myeon; Kim, Jintae; Kim, Hanshin; Madou, Marc; Cho, Yoon-Kyoung

    2010-07-21

    The centrifugal microfluidic platform has been a focus of academic and industrial research efforts for almost 40 years. Primarily targeting biomedical applications, a range of assays have been adapted on the system; however, the platform has found limited commercial success as a research or clinical tool. Nonetheless, new developments in centrifugal microfluidic technologies have the potential to establish wide-spread utilization of the platform. This paper presents an in-depth review of the centrifugal microfluidic platform, while highlighting recent progress in the field and outlining the potential for future applications. An overview of centrifugal microfluidic technologies is presented, including descriptions of advantages of the platform as a microfluidic handling system and the principles behind centrifugal fluidic manipulation. The paper also discusses a history of significant centrifugal microfluidic platform developments with an explanation of the evolution of the platform as it pertains to academia and industry. Lastly, we review the few centrifugal microfluidic-based sample-to-answer analysis systems shown to date and examine the challenges to be tackled before the centrifugal platform can be more broadly accepted as a new diagnostic platform. In particular, fully integrated, easy to operate, inexpensive and accurate microfluidic tools in the area of in vitro nucleic acid diagnostics are discussed.

  19. Forecasting catastrophe by exploiting chaotic dynamics

    SciTech Connect

    Stewart, H.B.; Lansbury, A.N.

    1990-01-01

    Our purpose here is to introduce a variation on the theme of short term forecasting from a chaotic time series. We show that for the lowest-dimensional chaotic attractors, it is possible to predict incipient catastrophes, or crises, by examining time series data taken near the catastrophic bifurcation threshold, but always remaining on the safe side of the threshold.

  20. Is Navier-Stokes turbulence chaotic?

    NASA Technical Reports Server (NTRS)

    Deissler, R. G.

    1986-01-01

    Whether turbulent solutions of the Navier-Stokes equations are chaotic is considered. Initially neighboring solutions for a low-Reynolds-number fully developed turbulence are compared. The turbulence is sustained by a nonrandom time-independent external force. The solutions separate exponentially with time, having a positive Liapunov characteristic exponent. Thus the turbulence is characterized as chaotic.

  1. CONTINUOUSLY SENSITIVE BUBBLE CHAMBER

    DOEpatents

    Good, R.H.

    1959-08-18

    A radiation detector of the bubble chamber class is described which is continuously sensitive and which does not require the complex pressure cycling equipment characteristic of prior forms of the chamber. The radiation sensitive element is a gas-saturated liquid and means are provided for establishing a thermal gradient across a region of the liquid. The gradient has a temperature range including both the saturation temperature of the liquid and more elevated temperatures. Thus a supersaturated zone is created in which ionizing radiations may give rise to visible gas bubbles indicative of the passage of the radiation through the liquid. Additional means are provided for replenishing the supply of gas-saturated liquid to maintaincontinuous sensitivity.

  2. Bubble dynamics in drinks

    NASA Astrophysics Data System (ADS)

    Broučková, Zuzana; Trávníček, Zdeněk; Šafařík, Pavel

    2014-03-01

    This study introduces two physical effects known from beverages: the effect of sinking bubbles and the hot chocolate sound effect. The paper presents two simple "kitchen" experiments. The first and second effects are indicated by means of a flow visualization and microphone measurement, respectively. To quantify the second (acoustic) effect, sound records are analyzed using time-frequency signal processing, and the obtained power spectra and spectrograms are discussed.

  3. Mechanisms of gas bubble retention

    SciTech Connect

    Gauglitz, P.A.; Mahoney, L.A.; Mendoza, D.P.; Miller, M.C.

    1994-09-01

    Retention and episodic release of flammable gases are critical safety concerns regarding double-shell tanks (DSTs) containing waste slurries. Previous investigations have concluded that gas bubbles are retained by the slurry that has settled at the bottom of the DST. However, the mechanisms responsible for the retention of these bubbles are not well understood. In addition, the presence of retained gas bubbles is expected to affect the physical properties of the sludge, but essentially no literature data are available to assess the effect of these bubbles. The rheological behavior of the waste, particularly of the settled sludge, is critical to characterizing the tendency of the waste to retain gas bubbles. The objectives of this study are to elucidate the mechanisms contributing to gas bubble retention and release from sludge such as is in Tank 241-SY-101, understand how the bubbles affect the physical properties of the sludge, develop correlations of these physical properties to include in computer models, and collect experimental data on the physical properties of simulated sludges with bubbles. This report presents a theory and experimental observations of bubble retention in simulated sludge and gives correlations and new data on the effect of gas bubbles on sludge yield strength.

  4. Sonoluminescence, sonochemistry and bubble dynamics of single bubble cavitation

    NASA Astrophysics Data System (ADS)

    Hatanaka, Shin-ichi

    2012-09-01

    The amount of hydroxyl radicals produced from a single cavitation bubble was quantified by terephthalate dosimetry at various frequencies and pressure amplitudes, while the dynamics of the single bubble was observed by stroboscopic and light-scattering methods. Also, sonoluminescence (SL), sonochemiluminescence (SCL) of luminol, and sodium atom emission (Na*) in the cavitation field were observed. The amount of hydroxyl radicals per cycle as well as the intensity of SL was proportional to pressure amplitude at every frequency performed, and it decreased with increasing frequency. When the single bubble was dancing with a decrease in pressure amplitude, however, the amount of hydroxyl radicals was greater than that for the stable bubble at the higher pressure amplitude and did not significantly decrease with frequency. Furthermore, SCL and Na* were detected only under unstable bubble conditions. These results imply that the instability of bubbles significantly enhances sonochemical efficiency for non-volatile substances in liquid phase.

  5. Non-metric chaotic inflation

    SciTech Connect

    Enqvist, Kari; Koivisto, Tomi; Rigopoulos, Gerasimos E-mail: T.S.Koivisto@astro.uio.no

    2012-05-01

    We consider inflation within the context of what is arguably the simplest non-metric extension of Einstein gravity. There non-metricity is described by a single graviscalar field with a non-minimal kinetic coupling to the inflaton field Ψ, parameterized by a single parameter γ. There is a simple equivalent description in terms of a massless field and an inflaton with a modified potential. We discuss the implications of non-metricity for chaotic inflation and find that it significantly alters the inflaton dynamics for field values Ψ∼>M{sub P}/γ, dramatically changing the qualitative behaviour in this regime. In the equivalent single-field description this is described as a cuspy potential that forms of barrier beyond which the inflation becomes a ghost field. This imposes an upper bound on the possible number of e-folds. For the simplest chaotic inflation models, the spectral index and the tensor-to-scalar ratio receive small corrections dependent on the non-metricity parameter. We also argue that significant post-inflationary non-metricity may be generated.

  6. The chaotic dynamics of jamming

    NASA Astrophysics Data System (ADS)

    Banigan, Edward J.; Illich, Matthew K.; Stace-Naughton, Derick J.; Egolf, David A.

    2013-05-01

    Granular materials are collections of discrete, macroscopic particles characterized by relatively straightforward interactions. Despite their apparent simplicity, these systems exhibit a number of intriguing phenomena, including the jamming transition, in which a disordered collection of grains becomes rigid when its density exceeds a critical value. Many aspects of this transition have been explored, but an explanation of the underlying dynamical mechanisms for the transition remains elusive. Here, applying nonlinear dynamical techniques to simulated two-dimensional Couette shear cells, we reveal the mechanisms of jamming and find that they conflict with the prevailing picture of growing cooperative regions. In addition, at the density corresponding to random close packing, we find a dynamical transition from chaotic to non-chaotic states accompanied by diverging dynamical length- and timescales. Furthermore, we find that the dominant cooperative dynamical modes are strongly correlated with particle rearrangements and become increasingly unstable before stress jumps, providing a way to predict the times and locations of these striking stress-release events in our simulations.

  7. Inertial microfluidic physics.

    PubMed

    Amini, Hamed; Lee, Wonhee; Di Carlo, Dino

    2014-08-01

    Microfluidics has experienced massive growth in the past two decades, and especially with advances in rapid prototyping researchers have explored a multitude of channel structures, fluid and particle mixtures, and integration with electrical and optical systems towards solving problems in healthcare, biological and chemical analysis, materials synthesis, and other emerging areas that can benefit from the scale, automation, or the unique physics of these systems. Inertial microfluidics, which relies on the unconventional use of fluid inertia in microfluidic platforms, is one of the emerging fields that make use of unique physical phenomena that are accessible in microscale patterned channels. Channel shapes that focus, concentrate, order, separate, transfer, and mix particles and fluids have been demonstrated, however physical underpinnings guiding these channel designs have been limited and much of the development has been based on experimentally-derived intuition. Here we aim to provide a deeper understanding of mechanisms and underlying physics in these systems which can lead to more effective and reliable designs with less iteration. To place the inertial effects into context we also discuss related fluid-induced forces present in particulate flows including forces due to non-Newtonian fluids, particle asymmetry, and particle deformability. We then highlight the inverse situation and describe the effect of the suspended particles acting on the fluid in a channel flow. Finally, we discuss the importance of structured channels, i.e. channels with boundary conditions that vary in the streamwise direction, and their potential as a means to achieve unprecedented three-dimensional control over fluid and particles in microchannels. Ultimately, we hope that an improved fundamental and quantitative understanding of inertial fluid dynamic effects can lead to unprecedented capabilities to program fluid and particle flow towards automation of biomedicine, materials

  8. Suitability of commercial software for direct numerical simulations of chaotic electrokinetic transport

    NASA Astrophysics Data System (ADS)

    Karatay, Elif; Mani, Ali

    2014-11-01

    Many microfluidic and electrochemical applications involve chaotic transport phenomena that arise due to instabilities stemming from coupling of hydrodynamics with ion transport and electrostatic forces. Recent investigations have revealed contribution of a wide range of spatio-temporal scales in such chaotic systems similar to those observed in turbulent flows. Given that these scales can span several orders of magnitude, significant numerical resolution is needed for accurate prediction of these phenomena. The objective of this work is to assess efficiency of commercial software for prediction of such phenomena. To this end we have considered Comsol Multiphysics as a general-purpose commercial CFD/transport solver, and have compared its performance against a custom-made DNS code tailored to the specific physics of chaotic electrokinetic phenomena. We present comparison for small systems, which can be simulated on a single core, and show detailed statistics including velocity and concentration spectra over a wide range of frequencies. Our results indicate that while accuracy can be guaranteed with proper mesh resolution, commercial solvers are generally at least an order of magnitude slower than custom-made DNS codes. Supported by NWO, Rubicon Grant.

  9. Microfluidic Cell Culture Device

    NASA Technical Reports Server (NTRS)

    Takayama, Shuichi (Inventor); Cabrera, Lourdes Marcella (Inventor); Heo, Yun Seok (Inventor); Smith, Gary Daniel (Inventor)

    2014-01-01

    Microfluidic devices for cell culturing and methods for using the same are disclosed. One device includes a substrate and membrane. The substrate includes a reservoir in fluid communication with a passage. A bio-compatible fluid may be added to the reservoir and passage. The reservoir is configured to receive and retain at least a portion of a cell mass. The membrane acts as a barrier to evaporation of the bio-compatible fluid from the passage. A cover fluid may be added to cover the bio-compatible fluid to prevent evaporation of the bio-compatible fluid.

  10. Spatial Manipulation with Microfluidics

    PubMed Central

    Lin, Benjamin; Levchenko, Andre

    2015-01-01

    Biochemical gradients convey information through space, time, and concentration, and are ultimately capable of spatially resolving distinct cellular phenotypes, such as differentiation, proliferation, and migration. How these gradients develop, evolve, and function during development, homeostasis, and various disease states is a subject of intense interest across a variety of disciplines. Microfluidic technologies have become essential tools for investigating gradient sensing in vitro due to their ability to precisely manipulate fluids on demand in well-controlled environments at cellular length scales. This review will highlight their utility for studying gradient sensing along with relevant applications to biology. PMID:25905100

  11. Bubble in a corner flow

    NASA Technical Reports Server (NTRS)

    Vanden-Broeck, J. M.

    1982-01-01

    The distortion of a two-dimensional bubble (or drop) in a corner of angle delta, due to the flow of an inviscid incompressible fluid around it, is examined theoretically. The flow and the bubble shape are determined as functions of the angle delta, the contact angle beta and the cavitation number gamma. The problem is formulated as an integrodifferential equation for the bubble surface. This equation generalized the integrodifferential equations derived by Vanden-Broeck and Keller. The shape of the bubble is found approximately by using the slender body theory for bubbles. When gamma reaches a critical value gamma sub 0 (beta, delta), opposite sides of the bubble touch each other. Two different families of solution for gamma gamma sub 0 are obtained. In the first family opposite sides touch at one point. In the second family contact is allowed along a segment.

  12. Stable Multibubble Sonoluminescence Bubble Patterns

    SciTech Connect

    Posakony, Gerald J.; Greenwood, Lawrence R.; Ahmed, Salahuddin

    2006-06-30

    Multibubble standing wave patterns can be generated from a flat piezoceramic transducer element propagating into water. By adding a second transducer positioned at 90 degrees from the transducer generating the standing wave, a 3-dimensional volume of stable single bubbles can be established. Further, the addition of the second transducer stabilizes the bubble pattern so that individual bubbles may be studied. The size of the bubbles and the separation of the standing waves depend on the frequency of operation. Two transducers, operating at frequencies above 500 kHz, provided the most graphic results for the configuration used in this study. At these frequencies stable bubbles exhibit a bright sonoluminescence pattern. Whereas stable SBSL is well-known, stable MBSL has not been previously reported. This paper includes discussions of the acoustic responses, standing wave patterns, and pictorial results of the separation of individual bubble of sonoluminescence in a multibubble sonoluminescence environment.

  13. Three-dimensional numerical simulations of a bubble rising in an unbounded weakly viscous fluid

    NASA Astrophysics Data System (ADS)

    Cano-Lozano, Jose Carlos; Martínez-Bazán, Carlos; Tchoufag, Joel; Magnaudet, Jacques

    2015-11-01

    Direct Numerical Simulations (DNS) of a freely rising bubble in an unbounded low-viscosity fluid are performed to analyze the bubble trajectory for values of Galileo and Bond numbers close to the transition between vertical and non-vertical paths. The simulations are performed with the Gerris Flow Solver, based on the Volume of Fluid technique to track the interface, allowing deformations of the bubble during its rising motion. We find the existence of novel regimes of the bubble rise which we describe by tracking the bubble shape, path geometry and wake vortical structures, as well as the temporal evolution of the instantaneous Reynolds number. Besides the traditional rectilinear, zigzag and spiral paths, we observe chaotic, reflectional-symmetry-breaking or reflectional-symmetry-preserving regimes previously reported for axisymmetric solid bodies. The DNS results also allow us to check the accuracy of the neutral curve defining the region of the parameter space within which the vertical path of a buoyancy-driven bubble with fore-and-aft asymmetric shape is linearly stable. Supported by the Spanish MINECO, Junta de Andalucía and EU Funds under projects DPI 2014-59292-C3-3-P and P11-TEP7495.

  14. In Search of the Big Bubble

    ERIC Educational Resources Information Center

    Simoson, Andrew; Wentzky, Bethany

    2011-01-01

    Freely rising air bubbles in water sometimes assume the shape of a spherical cap, a shape also known as the "big bubble". Is it possible to find some objective function involving a combination of a bubble's attributes for which the big bubble is the optimal shape? Following the basic idea of the definite integral, we define a bubble's surface as…

  15. Microelectrokinetic turbulence in microfluidics at low Reynolds number.

    PubMed

    Wang, Guiren; Yang, Fang; Zhao, Wei

    2016-01-01

    There is commonly no turbulence in microfluidics, and the flows are believed to be either laminar or chaotic, since Reynolds number (Re) in microflows is usually on the order of unity or lower. However, we recently demonstrated that it is possible to achieve turbulence with low Re (based on the measured flow velocity and the width of the channel entrance) when a pressure-driven flow is electrokinetically forced in a quasi T-microchannel. To be able to measure high frequency velocity fluctuations in microchannels, a velocimeter with submicrometer spatial resolution and microsecond temporal resolution, called a laser-induced fluorescence photobleaching anemometer, is developed. Here we characterize the microelectrokinetic turbulence and observe some typical and important features of high Re flows, such as Kolmogorov -5/3 spectrum of velocity fluctuation, which usually can be realized only at very high Re in macroturbulent flows.

  16. Microelectrokinetic turbulence in microfluidics at low Reynolds number.

    PubMed

    Wang, Guiren; Yang, Fang; Zhao, Wei

    2016-01-01

    There is commonly no turbulence in microfluidics, and the flows are believed to be either laminar or chaotic, since Reynolds number (Re) in microflows is usually on the order of unity or lower. However, we recently demonstrated that it is possible to achieve turbulence with low Re (based on the measured flow velocity and the width of the channel entrance) when a pressure-driven flow is electrokinetically forced in a quasi T-microchannel. To be able to measure high frequency velocity fluctuations in microchannels, a velocimeter with submicrometer spatial resolution and microsecond temporal resolution, called a laser-induced fluorescence photobleaching anemometer, is developed. Here we characterize the microelectrokinetic turbulence and observe some typical and important features of high Re flows, such as Kolmogorov -5/3 spectrum of velocity fluctuation, which usually can be realized only at very high Re in macroturbulent flows. PMID:26871154

  17. Microelectrokinetic turbulence in microfluidics at low Reynolds number

    NASA Astrophysics Data System (ADS)

    Wang, Guiren; Yang, Fang; Zhao, Wei

    2016-01-01

    There is commonly no turbulence in microfluidics, and the flows are believed to be either laminar or chaotic, since Reynolds number (Re) in microflows is usually on the order of unity or lower. However, we recently demonstrated that it is possible to achieve turbulence with low Re (based on the measured flow velocity and the width of the channel entrance) when a pressure-driven flow is electrokinetically forced in a quasi T-microchannel. To be able to measure high frequency velocity fluctuations in microchannels, a velocimeter with submicrometer spatial resolution and microsecond temporal resolution, called a laser-induced fluorescence photobleaching anemometer, is developed. Here we characterize the microelectrokinetic turbulence and observe some typical and important features of high Re flows, such as Kolmogorov -5 /3 spectrum of velocity fluctuation, which usually can be realized only at very high Re in macroturbulent flows.

  18. Microfluidic bubbler facilitates near complete mass transfer for sustainable multiphase and microbial processing.

    PubMed

    Baker, Jordan J; Crivellari, Francesca; Gagnon, Zachary; Betenbaugh, Michael J

    2016-09-01

    A microfluidic device (channels <70 μm) was utilized to create micro-scale bubbles to significantly increase mass transfer efficiency at low flow rates. The convergence of one gas and two liquid channels at a Y-junction generates bubbles via cyclic changes in pressure. At low flow rates, the bubbles had an average diameter of 110 μm, corresponding to a volumetric mass transfer KL a of 1.43 h(-1) . Values of KL a normalized per flow rate showed that the microbubbler had a 100-fold increased transfer efficiency compared to four other commonly used bubblers. The calculated percentage of oxygen transferred was approximately 90%, which was consistent with a separate off-gas analysis. The improved mass transfer was also tested in an algae bioreactor in which the microbubbler absorbed approximately 90% of the CO2 feed compared to 2% in the culture with an alternative needle bubbling method. The microbubbler yielded a cell density 82% of the cell density for the alternative needle tip with an 800-fold lower flow rate (0.5 mL/min versus 400 mL/min) and a 700-fold higher ratio of biomass to fed carbon dioxide. The application of microfluidics may transform interfacial processing in order to increase mass transfer efficiencies, minimize gas feeding, and provide for more sustainable multiphase processes. Biotechnol. Bioeng. 2016;113: 1924-1933. © 2016 Wiley Periodicals, Inc.

  19. Droplets, Bubbles and Ultrasound Interactions.

    PubMed

    Shpak, Oleksandr; Verweij, Martin; de Jong, Nico; Versluis, Michel

    2016-01-01

    The interaction of droplets and bubbles with ultrasound has been studied extensively in the last 25 years. Microbubbles are broadly used in diagnostic and therapeutic medical applications, for instance, as ultrasound contrast agents. They have a similar size as red blood cells, and thus are able to circulate within blood vessels. Perfluorocarbon liquid droplets can be a potential new generation of microbubble agents as ultrasound can trigger their conversion into gas bubbles. Prior to activation, they are at least five times smaller in diameter than the resulting bubbles. Together with the violent nature of the phase-transition, the droplets can be used for local drug delivery, embolotherapy, HIFU enhancement and tumor imaging. Here we explain the basics of bubble dynamics, described by the Rayleigh-Plesset equation, bubble resonance frequency, damping and quality factor. We show the elegant calculation of the above characteristics for the case of small amplitude oscillations by linearizing the equations. The effect and importance of a bubble coating and effective surface tension are also discussed. We give the main characteristics of the power spectrum of bubble oscillations. Preceding bubble dynamics, ultrasound propagation is introduced. We explain the speed of sound, nonlinearity and attenuation terms. We examine bubble ultrasound scattering and how it depends on the wave-shape of the incident wave. Finally, we introduce droplet interaction with ultrasound. We elucidate the ultrasound-focusing concept within a droplets sphere, droplet shaking due to media compressibility and droplet phase-conversion dynamics.

  20. Bubble Measuring Instrument and Method

    NASA Technical Reports Server (NTRS)

    Kline-Schoder, Robert (Inventor); Magari, Patrick J. (Inventor)

    2002-01-01

    Method and apparatus are provided for a non-invasive bubble measuring instrument operable for detecting, distinguishing, and counting gaseous embolisms such as bubbles over a selectable range of bubble sizes of interest. A selected measurement volume in which bubbles may be detected is insonified by two distinct frequencies from a pump transducer and an image transducer. respectively. The image transducer frequency is much higher than the pump transducer frequency. The relatively low-frequency pump signal is used to excite bubbles to resonate at a frequency related to their diameter. The image transducer is operated in a pulse-echo mode at a controllable repetition rate that transmits bursts of high-frequency ultrasonic signal to the measurement volume in which bubbles may be detected and then receives the echo. From the echo or received signal, a beat signal related to the repetition rate may be extracted and used to indicate the presence or absence of a resonant bubble. In a preferred embodiment, software control maintains the beat signal at a preselected frequency while varying the pump transducer frequency to excite bubbles of different diameters to resonate depending on the range of bubble diameters selected for investigation.

  1. Bubble measuring instrument and method

    NASA Technical Reports Server (NTRS)

    Kline-Schoder, Robert (Inventor); Magari, Patrick J. (Inventor)

    2003-01-01

    Method and apparatus are provided for a non-invasive bubble measuring instrument operable for detecting, distinguishing, and counting gaseous embolisms such as bubbles over a selectable range of bubble sizes of interest. A selected measurement volume in which bubbles may be detected is insonified by two distinct frequencies from a pump transducer and an image transducer, respectively. The image transducer frequency is much higher than the pump transducer frequency. The relatively low-frequency pump signal is used to excite bubbles to resonate at a frequency related to their diameter. The image transducer is operated in a pulse-echo mode at a controllable repetition rate that transmits bursts of high-frequency ultrasonic signal to the measurement volume in which bubbles may be detected and then receives the echo. From the echo or received signal, a beat signal related to the repetition rate may be extracted and used to indicate the presence or absence of a resonant bubble. In a preferred embodiment, software control maintains the beat signal at a preselected frequency while varying the pump transducer frequency to excite bubbles of different diameters to resonate depending on the range of bubble diameters selected for investigation.

  2. Neutron detection via bubble chambers.

    PubMed

    Jordan, D V; Ely, J H; Peurrung, A J; Bond, L J; Collar, J I; Flake, M; Knopf, M A; Pitts, W K; Shaver, M; Sonnenschein, A; Smart, J E; Todd, L C

    2005-01-01

    Research investigating the application of pressure-cycled bubble chambers to fast neutron detection is described. Experiments with a Halon-filled chamber showed clear sensitivity to an AmBe neutron source and insensitivity to a (137)Cs gamma source. Bubble formation was documented using high-speed photography, and a ceramic piezo-electric transducer element registered the acoustic signature of bubble formation. In a second set of experiments, the bubble nucleation response of a Freon-134a chamber to an AmBe neutron source was documented with high-speed photography.

  3. Helium bubble bursting in tungsten

    SciTech Connect

    Sefta, Faiza; Juslin, Niklas; Wirth, Brian D.

    2013-12-28

    Molecular dynamics simulations have been used to systematically study the pressure evolution and bursting behavior of sub-surface helium bubbles and the resulting tungsten surface morphology. This study specifically investigates how bubble shape and size, temperature, tungsten surface orientation, and ligament thickness above the bubble influence bubble stability and surface evolution. The tungsten surface is roughened by a combination of adatom “islands,” craters, and pinholes. The present study provides insight into the mechanisms and conditions leading to various tungsten topology changes, which we believe are the initial stages of surface evolution leading to the formation of nanoscale fuzz.

  4. Bubble Measuring Instrument and Method

    NASA Technical Reports Server (NTRS)

    Kline-Schoder, Robert (Inventor); Magari, Patrick J. (Inventor)

    2002-01-01

    Method and apparatus are provided for a non-invasive bubble measuring instrument operable for detecting, distinguishing, and counting gaseous embolisms such as bubbles over a selectable range of bubble sizes of interest. A selected measurement volume in which bubbles may be detected is insonified by two distinct frequencies from a pump transducer and an image transducer, respectively. The image transducer frequency is much higher than the pump transducer frequency. The relatively low-frequency pump signal is used to excite bubbles to resonate at a frequency related to their diameter. The image transducer is operated in a pulse-echo mode at a controllable repetition rate that transmits bursts of high-frequency ultrasonic signal to the measurement volume in which bubbles may be detected and then receives the echo. From the echo or received signal, a beat signal related to the repetition rate may be extracted and used to indicate the presence or absence of a resonant bubble. In a preferred embodiment, software control maintains the beat signal at a preselected frequency while varying the pump transducer frequency to excite bubbles of different diameters to resonate depending on the range of bubble diameters selected for investigation.

  5. Bubble Measuring Instrument and Method

    NASA Technical Reports Server (NTRS)

    Kline-Schoder, Robert (Inventor); Magari, Patrick J. (Inventor)

    2002-01-01

    Method and apparatus are provided for a non-invasive bubble measuring instrument operable for detecting. distinguishing, and counting gaseous embolisms such as bubbles over a selectable range of bubble sizes of interest. A selected measurement volume in which bubbles may be detected is insonified by two distinct frequencies from a pump transducer and an image transducer, respectively. The image transducer frequency is much higher than the pump transducer frequency. The relatively low-frequency pump signal is used to excite bubbles to resonate at a frequency related to their diameter. The image transducer is operated in a pulse-echo mode at a controllable repetition rate that transmits bursts of high-frequency ultrasonic signal to the measurement volume in which bubbles may be detected and then receive, the echo. From the echo or received signal, a beat signal related to the repetition rate may be extracted and used to indicate the presence or absence of a resonant bubble. In a preferred embodiment, software control maintains the beat signal at a preselected frequency while varying the pump transducer frequency to excite bubbles of different diameters to resonate depending on the range of bubble diameters selected for investigation.

  6. Multiple channel secure communication using chaotic system encoding

    SciTech Connect

    Miller, S.L.

    1996-12-31

    fA new method to encrypt signals using chaotic systems has been developed that offers benefits over conventional chaotic encryption methods. The method simultaneously encodes multiple plaintext streams using a chaotic system; a key is required to extract the plaintext from the chaotic cipertext. A working prototype demonstrates feasibility of the method by simultaneously encoding and decoding multiple audio signals using electrical circuits.

  7. Near-post meniscus-induced migration and assembly of bubbles.

    PubMed

    Liu, Jianlin; Li, Shanpeng; Hou, Jian

    2016-02-21

    Although the effect of interfacial tension of liquids is often negligible at the macroscale, it plays an essential role in areas such as superhydrophobicity on rough surfaces, water walking of aquatic creatures and self-assembly of small particles or droplets. In this study, we investigate the migration and assembly of bubbles near the meniscus produced by a slender post with various cross-sections. The results show that the bubble always migrates to the solid wall of the post, although the cross-section shape, material and tilt angle of the post are different. In particular, the final position of the bubble is not located at the singular point of the cross-section, which is beyond what we have imagined. We simulate the morphology of the triple contact line via Surface Evolver, and then address the mechanism of bubble's migration from the viewpoint of force analysis and energy calculation. The factors governing the final position of the bubble are analyzed according to the scaling law. These obtained results cast new light on modulating the assembly of bubbles and small droplets by varying the material, geometric shape and posture of the post in water. These findings also have important implications for oil collection and oil displacement in petroleum engineering, drug delivery, design of microfluidic devices and chemical sensors.

  8. Near-post meniscus-induced migration and assembly of bubbles.

    PubMed

    Liu, Jianlin; Li, Shanpeng; Hou, Jian

    2016-02-21

    Although the effect of interfacial tension of liquids is often negligible at the macroscale, it plays an essential role in areas such as superhydrophobicity on rough surfaces, water walking of aquatic creatures and self-assembly of small particles or droplets. In this study, we investigate the migration and assembly of bubbles near the meniscus produced by a slender post with various cross-sections. The results show that the bubble always migrates to the solid wall of the post, although the cross-section shape, material and tilt angle of the post are different. In particular, the final position of the bubble is not located at the singular point of the cross-section, which is beyond what we have imagined. We simulate the morphology of the triple contact line via Surface Evolver, and then address the mechanism of bubble's migration from the viewpoint of force analysis and energy calculation. The factors governing the final position of the bubble are analyzed according to the scaling law. These obtained results cast new light on modulating the assembly of bubbles and small droplets by varying the material, geometric shape and posture of the post in water. These findings also have important implications for oil collection and oil displacement in petroleum engineering, drug delivery, design of microfluidic devices and chemical sensors. PMID:26743021

  9. Electro-Microfluidic Packaging

    NASA Astrophysics Data System (ADS)

    Benavides, G. L.; Galambos, P. C.

    2002-06-01

    There are many examples of electro-microfluidic products that require cost effective packaging solutions. Industry has responded to a demand for products such as drop ejectors, chemical sensors, and biological sensors. Drop ejectors have consumer applications such as ink jet printing and scientific applications such as patterning self-assembled monolayers or ejecting picoliters of expensive analytes/reagents for chemical analysis. Drop ejectors can be used to perform chemical analysis, combinatorial chemistry, drug manufacture, drug discovery, drug delivery, and DNA sequencing. Chemical and biological micro-sensors can sniff the ambient environment for traces of dangerous materials such as explosives, toxins, or pathogens. Other biological sensors can be used to improve world health by providing timely diagnostics and applying corrective measures to the human body. Electro-microfluidic packaging can easily represent over fifty percent of the product cost and, as with Integrated Circuits (IC), the industry should evolve to standard packaging solutions. Standard packaging schemes will minimize cost and bring products to market sooner.

  10. Microfluidic Biochip Design

    NASA Technical Reports Server (NTRS)

    Panzarella, Charles

    2004-01-01

    As humans prepare for the exploration of our solar system, there is a growing need for miniaturized medical and environmental diagnostic devices for use on spacecrafts, especially during long-duration space missions where size and power requirements are critical. In recent years, the biochip (or Lab-on-a-Chip) has emerged as a technology that might be able to satisfy this need. In generic terms, a biochip is a miniaturized microfluidic device analogous to the electronic microchip that ushered in the digital age. It consists of tiny microfluidic channels, pumps and valves that transport small amounts of sample fluids to biosensors that can perform a variety of tests on those fluids in near real time. It has the obvious advantages of being small, lightweight, requiring less sample fluids and reagents and being more sensitive and efficient than larger devices currently in use. Some of the desired space-based applications would be to provide smaller, more robust devices for analyzing blood, saliva and urine and for testing water and food supplies for the presence of harmful contaminants and microorganisms. Our group has undertaken the goal of adapting as well as improving upon current biochip technology for use in long-duration microgravity environments.

  11. Urey Prize Lecture - Chaotic dynamics in the solar system

    NASA Technical Reports Server (NTRS)

    Wisdom, Jack

    1987-01-01

    Attention is given to solar system cases in which chaotic solutions of Newton's equations are important, as in chaotic rotation and orbital evolution. Hyperion is noted to be tumbling chaotically; chaotic orbital evolution is suggested to be of fundamental importance to an accounting for the Kirkwood gaps in asteroid distribution and for the phase space boundary of the chaotic zone at the 3/1 mean-motion commensurability with Jupiter. In addition, chaotic trajectories in the 2/1 chaotic zone reach very high eccentricities by a route that carries them to high inclinations temporarily.

  12. Regular transport dynamics produce chaotic travel times

    NASA Astrophysics Data System (ADS)

    Villalobos, Jorge; Muñoz, Víctor; Rogan, José; Zarama, Roberto; Johnson, Neil F.; Toledo, Benjamín; Valdivia, Juan Alejandro

    2014-06-01

    In the hope of making passenger travel times shorter and more reliable, many cities are introducing dedicated bus lanes (e.g., Bogota, London, Miami). Here we show that chaotic travel times are actually a natural consequence of individual bus function, and hence of public transport systems more generally, i.e., chaotic dynamics emerge even when the route is empty and straight, stops and lights are equidistant and regular, and loading times are negligible. More generally, our findings provide a novel example of chaotic dynamics emerging from a single object following Newton's laws of motion in a regularized one-dimensional system.

  13. Regular transport dynamics produce chaotic travel times.

    PubMed

    Villalobos, Jorge; Muñoz, Víctor; Rogan, José; Zarama, Roberto; Johnson, Neil F; Toledo, Benjamín; Valdivia, Juan Alejandro

    2014-06-01

    In the hope of making passenger travel times shorter and more reliable, many cities are introducing dedicated bus lanes (e.g., Bogota, London, Miami). Here we show that chaotic travel times are actually a natural consequence of individual bus function, and hence of public transport systems more generally, i.e., chaotic dynamics emerge even when the route is empty and straight, stops and lights are equidistant and regular, and loading times are negligible. More generally, our findings provide a novel example of chaotic dynamics emerging from a single object following Newton's laws of motion in a regularized one-dimensional system.

  14. Chaotic neurodynamics for autonomous agents.

    PubMed

    Harter, Derek; Kozma, Robert

    2005-05-01

    Mesoscopic level neurodynamics study the collective dynamical behavior of neural populations. Such models are becoming increasingly important in understanding large-scale brain processes. Brains exhibit aperiodic oscillations with a much more rich dynamical behavior than fixed-point and limit-cycle approximation allow. Here we present a discretized model inspired by Freeman's K-set mesoscopic level population model. We show that this version is capable of replicating the important principles of aperiodic/chaotic neurodynamics while being fast enough for use in real-time autonomous agent applications. This simplification of the K model provides many advantages not only in terms of efficiency but in simplicity and its ability to be analyzed in terms of its dynamical properties. We study the discrete version using a multilayer, highly recurrent model of the neural architecture of perceptual brain areas. We use this architecture to develop example action selection mechanisms in an autonomous agent. PMID:15940987

  15. Advective coalescence in chaotic flows.

    PubMed

    Nishikawa, T; Toroczkai, Z; Grebogi, C

    2001-07-16

    We investigate the reaction kinetics of small spherical particles with inertia, obeying coalescence type of reaction, B+B-->B, and being advected by hydrodynamical flows with time-periodic forcing. In contrast to passive tracers, the particle dynamics is governed by the strongly nonlinear Maxey-Riley equations, which typically create chaos in the spatial component of the particle dynamics, appearing as filamental structures in the distribution of the reactants. Defining a stochastic description supported on the natural measure of the attractor, we show that, in the limit of slow reaction, the reaction kinetics assumes a universal behavior exhibiting a t(-1) decay in the amount of reagents, which become distributed on a subset of dimension D2, where D2 is the correlation dimension of the chaotic flow. PMID:11461595

  16. Chaotic desynchronization of multistrain diseases

    NASA Astrophysics Data System (ADS)

    Shaw, Leah; Billings, Lora; McCrary, Marie; Schwartz, Ira

    2005-03-01

    Dengue fever, a multi-strain disease, has four distinct co-existing serotypes (strains). The serotypes interact by antibody-dependent enhancement (ADE), in which infection with a single serotype is asymptomatic, but contact with a second serotype leads to serious illness accompanied by greater infectivity. It has been observed from serotype data that outbreaks of the four serotypes occur asynchronously (Nisalak et al., Am. J. Trop. Med. Hyg. 68: 192). We developed a compartmental model and did bifurcation analysis for multiple serotypes with ADE. Both autonomous and seasonally driven versions were studied. For sufficiently small ADE, we find that the number of infectives of each serotype synchronizes, with outbreaks occurring in phase. However, when the ADE increases past a threshold, the system becomes chaotic, and infectives of each serotype desynchronize.

  17. Chaotic behavior of nuclear spectra

    NASA Astrophysics Data System (ADS)

    Mitchell, G. E.; Bilpuch, E. G.; Endt, P. M.; Shriner, J. F.; von Egidy, T.

    1991-05-01

    Bohigas, Giannoni and Schmit conjectured that quantum analogs of classically chaotic systems have level statistics which are consistent with the Gaussian orthogonal ensemble (GOE) of random matrix theory. This suggests that the fluctuation properties of nuclear levels may be used as a signature for chaos or regularity. Resonance data are known to display the long and short range order predicted by GOE. In one nucleus, 26Al, all levels are known from the ground state to the resonance region. This provides the first experimental test of the behavior of fluctuation properties as a function of symmetry breaking — in this case, isospin. In addition there are many nuclides where level schemes are complete over a more limited range of energies and spins. Our analysis of a large data set (~ 160 sequences in 60 nuclides) reveals a strong dependence on the mass number A.

  18. Effect of bubble size on micro-bubble drag reduction

    NASA Astrophysics Data System (ADS)

    Shen, Xiaochun

    2005-11-01

    The effect of bubble size on micro-bubble drag reduction was investigated experimentally in a high-speed turbulent channel flow of water. A variety of near-wall injection techniques were used to create a bubbly turbulent boundary layer. The resulting wall friction force was measured directly by a floating element force balance. The bubble size was determined from photographic imaging. Using compressed nitrogen to force flow through a slot injector located in the plate beneath the boundary layer of the tunnel test section, a surfactant solution (Triton X-100, 19ppm) and salt water solution (35ppt) generated bubbles of average size between ˜500 microns and ˜200 microns and ˜100 microns, respectively (40 < d^+ < 200). In addition hollow spherical glass beads (˜75 microns (d^+ = 30) and specific gravity 0.18) and previously prepared lipid stabilized gas bubbles of ˜ 30 micron (d^+ =12) were injected. The results indicate that the drag reduction is related strongly to the injected gas volume flux and the static pressure in the boundary layer. Changing bubble size had essentially no influence on the measured friction drag, suggesting that friction drag is not a strong function of bubble size. [Sponsored by the Office of Naval Research.

  19. Nonequilibrium bubbles in a flowing langmuir monolayer.

    PubMed

    Muruganathan, Rm; Khattari, Z; Fischer, Th M

    2005-11-24

    We investigate the nonequilibrium behavior of two-dimensional gas bubbles in Langmuir monolayers. A cavitation bubble is induced in liquid expanded phase by locally heating a Langmuir monolayer with an IR-laser. At low IR-laser power the cavitation bubble is immersed in quiescent liquid expanded monolayer. At higher IR-laser power thermo capillary flow around the laser-induced cavitation bubble sets in. The thermo capillary flow is caused by a temperature dependence of the gas/liquid line tension. The slope of the line tension with temperature is determined by measuring the thermo capillary flow velocity. Thermodynamically stable satellite bubbles are generated by increasing the surface area of the monolayer. Those satellite bubbles collide with the cavitation bubble. Upon collision the satellite bubbles either coalesce with the cavitation bubble or slide past the cavitation bubble. Moreover we show that the satellite bubbles can also be produced by the emission from the laser-induced cavitation bubbles.

  20. Experimental investigation of quasiperiodic-chaotic-quasiperiodic-chaotic transition in a direct current magnetron sputtering plasma

    SciTech Connect

    Sabavath, Gopi Kishan; Banerjee, I.; Mahapatra, S. K.; Shaw, Pankaj Kumar; Sekar Iyengar, A. N.

    2015-08-15

    Floating potential fluctuations from a direct current magnetron sputtering plasma have been analysed using time series analysis techniques like phase space plots, power spectra, frequency bifurcation plot, etc. The system exhibits quasiperiodic-chaotic-quasiperiodic-chaotic transitions as the discharge voltage was increased. The transitions of the fluctuations, quantified using the largest Lyapunov exponent, have been corroborated by Hurst exponent and the Shannon entropy. The Shannon entropy is high for quasiperiodic and low for chaotic oscillations.

  1. Bubble levitation and translation under single-bubble sonoluminescence conditions.

    PubMed

    Matula, Thomas J

    2003-08-01

    Bubble levitation in an acoustic standing wave is re-examined for conditions relevant to single-bubble sonoluminescence. Unlike a previous examination [Matula et al., J. Acoust. Soc. Am. 102, 1522-1527 (1997)], the stable parameter space [Pa,R0] is accounted for in this realization. Forces such as the added mass force and drag are included, and the results are compared with a simple force balance that equates the Bjerknes force to the buoyancy force. Under normal sonoluminescence conditions, the comparison is quite favorable. A more complete accounting of the forces shows that a stably levitated bubble does undergo periodic translational motion. The asymmetries associated with translational motion are hypothesized to generate instabilities in the spherical shape of the bubble. A reduction in gravity results in reduced translational motion. It is hypothesized that such conditions may lead to increased light output from sonoluminescing bubbles. PMID:12942960

  2. Bubble levitation and translation under single-bubble sonoluminescence conditions

    NASA Astrophysics Data System (ADS)

    Matula, Thomas J.

    2003-08-01

    Bubble levitation in an acoustic standing wave is re-examined for conditions relevant to single-bubble sonoluminescence. Unlike a previous examination [Matula et al., J. Acoust. Soc. Am. 102, 1522-1527 (1997)], the stable parameter space [Pa,R0] is accounted for in this realization. Forces such as the added mass force and drag are included, and the results are compared with a simple force balance that equates the Bjerknes force to the buoyancy force. Under normal sonoluminescence conditions, the comparison is quite favorable. A more complete accounting of the forces shows that a stably levitated bubble does undergo periodic translational motion. The asymmetries associated with translational motion are hypothesized to generate instabilities in the spherical shape of the bubble. A reduction in gravity results in reduced translational motion. It is hypothesized that such conditions may lead to increased light output from sonoluminescing bubbles.

  3. Stable tridimensional bubble clusters in multi-bubble sonoluminescence (MBSL).

    PubMed

    Rosselló, J M; Dellavale, D; Bonetto, F J

    2015-01-01

    In the present work, stable clusters made of multiple sonoluminescent bubbles are experimentally and theoretically studied. Argon bubbles were acoustically generated and trapped using bi-frequency driving within a cylindrical chamber filled with a sulfuric acid aqueous solution (SA85w/w). The intensity of the acoustic pressure field was strong enough to sustain, during several minutes, a large number of positionally and spatially fixed (without pseudo-orbits) sonoluminescent bubbles over an ellipsoidally-shaped tridimensional array. The dimensions of the ellipsoids were studied as a function of the amplitude of the applied low-frequency acoustic pressure (PAc(LF)) and the static pressure in the fluid (P0). In order to explain the size and shape of the bubble clusters, we performed a series of numerical simulations of the hydrodynamic forces acting over the bubbles. In both cases the observed experimental behavior was in excellent agreement with the numerical results. The simulations revealed that the positionally stable region, mainly determined by the null primary Bjerknes force (F→Bj), is defined as the outer perimeter of an axisymmetric ellipsoidal cluster centered in the acoustic field antinode. The role of the high-frequency component of the pressure field and the influence of the secondary Bjerknes force are discussed. We also investigate the effect of a change in the concentration of dissolved gas on the positional and spatial instabilities through the cluster dimensions. The experimental and numerical results presented in this paper are potentially useful for further understanding and modeling numerous current research topics regarding multi-bubble phenomena, e.g. forces acting on the bubbles in multi-frequency acoustic fields, transient acoustic cavitation, bubble interactions, structure formation processes, atomic and molecular emissions of equal bubbles and nonlinear or unsteady acoustic pressure fields in bubbly media. PMID:24974006

  4. Stable tridimensional bubble clusters in multi-bubble sonoluminescence (MBSL).

    PubMed

    Rosselló, J M; Dellavale, D; Bonetto, F J

    2015-01-01

    In the present work, stable clusters made of multiple sonoluminescent bubbles are experimentally and theoretically studied. Argon bubbles were acoustically generated and trapped using bi-frequency driving within a cylindrical chamber filled with a sulfuric acid aqueous solution (SA85w/w). The intensity of the acoustic pressure field was strong enough to sustain, during several minutes, a large number of positionally and spatially fixed (without pseudo-orbits) sonoluminescent bubbles over an ellipsoidally-shaped tridimensional array. The dimensions of the ellipsoids were studied as a function of the amplitude of the applied low-frequency acoustic pressure (PAc(LF)) and the static pressure in the fluid (P0). In order to explain the size and shape of the bubble clusters, we performed a series of numerical simulations of the hydrodynamic forces acting over the bubbles. In both cases the observed experimental behavior was in excellent agreement with the numerical results. The simulations revealed that the positionally stable region, mainly determined by the null primary Bjerknes force (F→Bj), is defined as the outer perimeter of an axisymmetric ellipsoidal cluster centered in the acoustic field antinode. The role of the high-frequency component of the pressure field and the influence of the secondary Bjerknes force are discussed. We also investigate the effect of a change in the concentration of dissolved gas on the positional and spatial instabilities through the cluster dimensions. The experimental and numerical results presented in this paper are potentially useful for further understanding and modeling numerous current research topics regarding multi-bubble phenomena, e.g. forces acting on the bubbles in multi-frequency acoustic fields, transient acoustic cavitation, bubble interactions, structure formation processes, atomic and molecular emissions of equal bubbles and nonlinear or unsteady acoustic pressure fields in bubbly media.

  5. Lipid bilayer vesicle generation using microfluidic jetting.

    PubMed

    Coyne, Christopher W; Patel, Karan; Heureaux, Johanna; Stachowiak, Jeanne; Fletcher, Daniel A; Liu, Allen P

    2014-01-01

    Bottom-up synthetic biology presents a novel approach for investigating and reconstituting biochemical systems and, potentially, minimal organisms. This emerging field engages engineers, chemists, biologists, and physicists to design and assemble basic biological components into complex, functioning systems from the bottom up. Such bottom-up systems could lead to the development of artificial cells for fundamental biological inquiries and innovative therapies(1,2). Giant unilamellar vesicles (GUVs) can serve as a model platform for synthetic biology due to their cell-like membrane structure and size. Microfluidic jetting, or microjetting, is a technique that allows for the generation of GUVs with controlled size, membrane composition, transmembrane protein incorporation, and encapsulation(3). The basic principle of this method is the use of multiple, high-frequency fluid pulses generated by a piezo-actuated inkjet device to deform a suspended lipid bilayer into a GUV. The process is akin to blowing soap bubbles from a soap film. By varying the composition of the jetted solution, the composition of the encompassing solution, and/or the components included in the bilayer, researchers can apply this technique to create customized vesicles. This paper describes the procedure to generate simple vesicles from a droplet interface bilayer by microjetting. PMID:24637415

  6. Lipid Bilayer Vesicle Generation Using Microfluidic Jetting

    PubMed Central

    Coyne, Christopher W.; Patel, Karan; Heureaux, Johanna; Stachowiak, Jeanne; Fletcher, Daniel A.; Liu, Allen P.

    2014-01-01

    Bottom-up synthetic biology presents a novel approach for investigating and reconstituting biochemical systems and, potentially, minimal organisms. This emerging field engages engineers, chemists, biologists, and physicists to design and assemble basic biological components into complex, functioning systems from the bottom up. Such bottom-up systems could lead to the development of artificial cells for fundamental biological inquiries and innovative therapies1,2. Giant unilamellar vesicles (GUVs) can serve as a model platform for synthetic biology due to their cell-like membrane structure and size. Microfluidic jetting, or microjetting, is a technique that allows for the generation of GUVs with controlled size, membrane composition, transmembrane protein incorporation, and encapsulation3. The basic principle of this method is the use of multiple, high-frequency fluid pulses generated by a piezo-actuated inkjet device to deform a suspended lipid bilayer into a GUV. The process is akin to blowing soap bubbles from a soap film. By varying the composition of the jetted solution, the composition of the encompassing solution, and/or the components included in the bilayer, researchers can apply this technique to create customized vesicles. This paper describes the procedure to generate simple vesicles from a droplet interface bilayer by microjetting. PMID:24637415

  7. Lipid bilayer vesicle generation using microfluidic jetting.

    PubMed

    Coyne, Christopher W; Patel, Karan; Heureaux, Johanna; Stachowiak, Jeanne; Fletcher, Daniel A; Liu, Allen P

    2014-02-21

    Bottom-up synthetic biology presents a novel approach for investigating and reconstituting biochemical systems and, potentially, minimal organisms. This emerging field engages engineers, chemists, biologists, and physicists to design and assemble basic biological components into complex, functioning systems from the bottom up. Such bottom-up systems could lead to the development of artificial cells for fundamental biological inquiries and innovative therapies(1,2). Giant unilamellar vesicles (GUVs) can serve as a model platform for synthetic biology due to their cell-like membrane structure and size. Microfluidic jetting, or microjetting, is a technique that allows for the generation of GUVs with controlled size, membrane composition, transmembrane protein incorporation, and encapsulation(3). The basic principle of this method is the use of multiple, high-frequency fluid pulses generated by a piezo-actuated inkjet device to deform a suspended lipid bilayer into a GUV. The process is akin to blowing soap bubbles from a soap film. By varying the composition of the jetted solution, the composition of the encompassing solution, and/or the components included in the bilayer, researchers can apply this technique to create customized vesicles. This paper describes the procedure to generate simple vesicles from a droplet interface bilayer by microjetting.

  8. Solvent resistant microfluidic DNA synthesizer.

    PubMed

    Huang, Yanyi; Castrataro, Piero; Lee, Cheng-Chung; Quake, Stephen R

    2007-01-01

    We fabricated a microfluidic DNA synthesizer out of perfluoropolyether (PFPE), an elastomer with excellent chemical compatibility which makes it possible to perform organic chemical reactions, and synthesized 20-mer oligonucleotides on chip. PMID:17180201

  9. Radiolytic Bubble Gas Hydrogen Compositions

    SciTech Connect

    Hester, J.R.

    2003-02-05

    Radioactive waste solids can trap bubbles containing hydrogen that may pose a flammability risk if they are disturbed and hydrogen is released. Whether a release is a problem or not depends, among other things, on the hydrogen composition of the gas. This report develops a method for estimating the hydrogen composition of trapped bubbles based on waste properties.

  10. Radiolytic Bubble Gas Hydrogen Compositions

    SciTech Connect

    Hester, J.R.

    2001-08-28

    Radioactive waste solids can trap bubbles containing hydrogen that may pose a flammability risk if they are disturbed and hydrogen is released. Whether a release is a problem or not depends, among other things, on the hydrogen composition of the gas. This report develops a method for estimating the hydrogen composition of trapped bubbles based on waste properties.

  11. Acoustic Behavior of Vapor Bubbles

    NASA Technical Reports Server (NTRS)

    Prosperetti, Andrea; Oguz, Hasan N.

    1996-01-01

    In a microgravity environment vapor bubbles generated at a boiling surface tend to remain near it for a long time. This affects the boiling heat transfer and in particular promotes an early transition to the highly inefficient film boiling regime. This paper describes the physical basis underlying attempts to remove the bubbles by means of pressure radiation forces.

  12. Bubbles under stress

    NASA Astrophysics Data System (ADS)

    Bohn, S.

    2003-06-01

    We present an experimental and theoretical investigation of a system composed of two soap bubbles strained between two parallel solid surfaces. The two-bubble cluster can be found in several configurations. The existence and stability of each of these states is studied as a function of the distance between the two facing surfaces. The change of this distance can induce a transition from one configuration to another; we observe that most transitions are subcritical, showing that the system is often trapped in states where the minimum of free energy is only local. The hysteretic transitions are responsible for the dissipation of elastic energy. The existence of more than one stable states for given boundaries conditions combined with the absence of thermalization means that the history of the system has to be taken into account and that there is no unique stress-strain relation. In the present system, because of its simplicity, a complete quantitative analysis of these general processes is obtained. The presented results may contribute to a better understanding of the dynamics of more complex systems such as foams or granular materials where similar processes are at work.

  13. Bubble formation in microgravity

    NASA Technical Reports Server (NTRS)

    Antar, Basil N.

    1996-01-01

    An extensive experimental program was initiated for the purpose of understanding the mechanisms leading to bubble generation during fluid handling procedures in a microgravity environment. Several key fluid handling procedures typical for PCG experiments were identified for analysis in that program. Experiments were designed to specifically understand how such procedures can lead to bubble formation. The experiments were then conducted aboard the NASA KC-135 aircraft which is capable of simulating a low gravity environment by executing a parabolic flight attitude. However, such a flight attitude can only provide a low gravity environment of approximately 10-2go for a maximum period of 30 seconds. Thus all of the tests conducted for these experiments were designed to last no longer than 20 seconds. Several experiments were designed to simulate some of the more relevant fluid handling procedures during protein crystal growth experiments. These include submerged liquid jet cavitation, filling of a cubical vessel, submerged surface scratch, attached drop growth, liquid jet impingement, and geysering experiments. To date, four separate KC-135 flight campaigns were undertaken specifically for performing these experiments. However, different experiments were performed on different flights.

  14. Bubble formation in microgravity

    NASA Technical Reports Server (NTRS)

    Antar, Basil N.

    1994-01-01

    Two KC-135 flight campaigns have been conducted to date which are specifically dedicated to study bubble formation in microgravity. The first flight was conducted during March 14-18, 1994, and the other during June 20-24, 1994. The results from the June 1994 flight have not been analyzed yet, while the results from the March flight have been partially analyzed. In the first flight three different experiments were performed, one with the specific aim at determining whether or not cavitation can take place during any of the fluid handling procedures adopted in the shuttle bioprocessing experiments. The other experiments were concerned with duplicating some of the procedures that resulted in bubble formation, namely the NCS filling procedure and the needle scratch of a solid surface. The results from this set of experiments suggest that cavitation did not take place during any of the fluid handling procedures. The results clearly indicate that almost all were generated as a result of the breakup of the gas/liquid interface. This was convincingly demonstrated in the scratch tests as well as in the liquid fill tests.

  15. Bubbles under stress.

    PubMed

    Bohn, S

    2003-06-01

    We present an experimental and theoretical investigation of a system composed of two soap bubbles strained between two parallel solid surfaces. The two-bubble cluster can be found in several configurations. The existence and stability of each of these states is studied as a function of the distance between the two facing surfaces. The change of this distance can induce a transition from one configuration to another; we observe that most transitions are subcritical, showing that the system is often trapped in states where the minimum of free energy is only local. The hysteretic transitions are responsible for the dissipation of elastic energy. The existence of more than one stable states for given boundaries conditions combined with the absence of thermalization means that the history of the system has to be taken into account and that there is no unique stress-strain relation. In the present system, because of its simplicity, a complete quantitative analysis of these general processes is obtained. The presented results may contribute to a better understanding of the dynamics of more complex systems such as foams or granular materials where similar processes are at work. PMID:15011058

  16. Chaotic dynamics near steep transition states

    NASA Astrophysics Data System (ADS)

    Green, Jason R.; Hofer, Thomas S.; Wales, David J.; Berry, R. Stephen

    2012-08-01

    Classical molecular motion near potential energy saddles can be more or less chaotic relative to motion near minima. The relative degree of chaos depends on the extent of coupling between the degrees of freedom and on the curvature of the potential energy landscape. Here, we explore these effects using constant energy molecular dynamics simulations and independent criteria associated with locally chaotic behavior - namely, the constancy of the local mode action and the magnitude of finite-time Lyapunov exponents. These criteria reconcile the chaotic basins and relatively ordered saddles of the Lennard-Jones trimer, with the chaotic saddles and ordered basins for reactive, all-atom H2O described by the Garofalini H2O potential. By modifying the Garofalini and Lennard-Jones models we separate the compounding effects of nonlinear three-body interactions and steep reaction path curvature on the local degree of chaos near saddles and minima.

  17. A practical test for noisy chaotic dynamics

    NASA Astrophysics Data System (ADS)

    BenSaïda, Ahmed

    2015-12-01

    This code computes the largest Lyapunov exponent and tests for the presence of a chaotic dynamics, as opposed to stochastic dynamics, in a noisy scalar series. The program runs under MATLAB​® programming language.

  18. Designing Chaotic Systems by Piecewise Affine Systems

    NASA Astrophysics Data System (ADS)

    Wu, Tiantian; Li, Qingdu; Yang, Xiao-Song

    Based on mathematical analysis, this paper provides a methodology to ensure the existence of homoclinic orbits in a class of three-dimensional piecewise affine systems. In addition, two chaotic generators are provided to illustrate the effectiveness of the method.

  19. Passive microfluidic array card and reader

    SciTech Connect

    Dugan, Lawrence Christopher; Coleman, Matthew A.

    2011-08-09

    A microfluidic array card and reader system for analyzing a sample. The microfluidic array card includes a sample loading section for loading the sample onto the microfluidic array card, a multiplicity of array windows, and a transport section or sections for transporting the sample from the sample loading section to the array windows. The microfluidic array card reader includes a housing, a receiving section for receiving the microfluidic array card, a viewing section, and a light source that directs light to the array window of the microfluidic array card and to the viewing section.

  20. Towards printable open air microfluidics.

    SciTech Connect

    Collord, Andrew; Cook, Adam W.; Clem, Paul Gilbert; Fenton, Kyle Ross; Apblett, Christopher Alan; Branson, Eric D.

    2010-04-01

    We have demonstrated a novel microfluidic technique for aqueous media, which uses super-hydrophobic materials to create microfluidic channels that are open to the atmosphere. We have demonstrated the ability to perform traditional electrokinetic operations such as ionic separations and electrophoresis using these devices. The rate of evaporation was studied and found to increase with decreasing channel size, which places a limitation on the minimum size of channel that could be used for such a device.

  1. Microfluidic serial dilution ladder.

    PubMed

    Ahrar, Siavash; Hwang, Michelle; Duncan, Philip N; Hui, Elliot E

    2014-01-01

    Serial dilution is a fundamental procedure that is common to a large number of laboratory protocols. Automation of serial dilution is thus a valuable component for lab-on-a-chip systems. While a handful of different microfluidic strategies for serial dilution have been reported, approaches based on continuous flow mixing inherently consume larger amounts of sample volume and chip real estate. We employ valve-driven circulatory mixing to address these issues and also introduce a novel device structure to store each stage of the dilution process. The dilution strategy is based on sequentially mixing the rungs of a ladder structure. We demonstrate a 7-stage series of 1 : 1 dilutions with R(2) equal to 0.995 in an active device area of 1 cm(2).

  2. Enhanced Microfluidic Electromagnetic Measurements

    NASA Technical Reports Server (NTRS)

    Giovangrandi, Laurent (Inventor); Ricco, Antonio J. (Inventor); Kovacs, Gregory (Inventor)

    2015-01-01

    Techniques for enhanced microfluidic impedance spectroscopy include causing a core fluid to flow into a channel between two sheath flows of one or more sheath fluids different from the core fluid. Flow in the channel is laminar. A dielectric constant of a fluid constituting either sheath flow is much less than a dielectric constant of the core fluid. Electrical impedance is measured in the channel between at least a first pair of electrodes. In some embodiments, enhanced optical measurements include causing a core fluid to flow into a channel between two sheath flows of one or more sheath fluids different from the core fluid. An optical index of refraction of a fluid constituting either sheath flow is much less than an optical index of refraction of the core fluid. An optical property is measured in the channel.

  3. Inertial Focusing in Microfluidics

    PubMed Central

    Martel, Joseph M.; Toner, Mehmet

    2015-01-01

    When Segré and Silberberg in 1961 witnessed particles in a laminar pipe flow congregating at an annulus in the pipe, scientists were perplexed and spent decades learning why such behavior occurred, finally understanding that it was caused by previously unknown forces on particles in an inertial flow. The advent of microfluidics opened a new realm of possibilities for inertial focusing in the processing of biological fluids and cellular suspensions and created a field that is now rapidly expanding. Over the past five years, inertial focusing has enabled high-throughput, simple, and precise manipulation of bodily fluids for a myriad of applications in point-of-care and clinical diagnostics. This review describes the theoretical developments that have made the field of inertial focusing what it is today and presents the key applications that will make inertial focusing a mainstream technology in the future. PMID:24905880

  4. Electrodes for microfluidic applications

    DOEpatents

    Crocker, Robert W.; Harnett, Cindy K.; Rognlien, Judith L.

    2006-08-22

    An electrode device for high pressure applications. These electrodes, designed to withstand pressure of greater than 10,000 psi, are adapted for use in microfluidic devices that employ electrokinetic or electrophoretic flow. The electrode is composed, generally, of an outer electrically insulating tubular body having a porous ceramic frit material disposed in one end of the outer body. The pores of the porous ceramic material are filled with an ion conductive polymer resin. A conductive material situated on the upper surface of the porous ceramic frit material and, thus isolated from direct contact with the electrolyte, forms a gas diffusion electrode. A metal current collector, in contact with the gas diffusion electrode, provides connection to a voltage source.

  5. Digital Microfluidic Cell Culture.

    PubMed

    Ng, Alphonsus H C; Li, Bingyu Betty; Chamberlain, M Dean; Wheeler, Aaron R

    2015-01-01

    Digital microfluidics (DMF) is a droplet-based liquid-handling technology that has recently become popular for cell culture and analysis. In DMF, picoliter- to microliter-sized droplets are manipulated on a planar surface using electric fields, thus enabling software-reconfigurable operations on individual droplets, such as move, merge, split, and dispense from reservoirs. Using this technique, multistep cell-based processes can be carried out using simple and compact instrumentation, making DMF an attractive platform for eventual integration into routine biology workflows. In this review, we summarize the state-of-the-art in DMF cell culture, and describe design considerations, types of DMF cell culture, and cell-based applications of DMF. PMID:26643019

  6. Parallel Imaging Microfluidic Cytometer

    PubMed Central

    Ehrlich, Daniel J.; McKenna, Brian K.; Evans, James G.; Belkina, Anna C.; Denis, Gerald V.; Sherr, David; Cheung, Man Ching

    2011-01-01

    By adding an additional degree of freedom from multichannel flow, the parallel microfluidic cytometer (PMC) combines some of the best features of flow cytometry (FACS) and microscope-based high-content screening (HCS). The PMC (i) lends itself to fast processing of large numbers of samples, (ii) adds a 1-D imaging capability for intracellular localization assays (HCS), (iii) has a high rare-cell sensitivity and, (iv) has an unusual capability for time-synchronized sampling. An inability to practically handle large sample numbers has restricted applications of conventional flow cytometers and microscopes in combinatorial cell assays, network biology, and drug discovery. The PMC promises to relieve a bottleneck in these previously constrained applications. The PMC may also be a powerful tool for finding rare primary cells in the clinic. The multichannel architecture of current PMC prototypes allows 384 unique samples for a cell-based screen to be read out in approximately 6–10 minutes, about 30-times the speed of most current FACS systems. In 1-D intracellular imaging, the PMC can obtain protein localization using HCS marker strategies at many times the sample throughput of CCD-based microscopes or CCD-based single-channel flow cytometers. The PMC also permits the signal integration time to be varied over a larger range than is practical in conventional flow cytometers. The signal-to-noise advantages are useful, for example, in counting rare positive cells in the most difficult early stages of genome-wide screening. We review the status of parallel microfluidic cytometry and discuss some of the directions the new technology may take. PMID:21704835

  7. Digital Microfluidics Sample Analyzer

    NASA Technical Reports Server (NTRS)

    Pollack, Michael G.; Srinivasan, Vijay; Eckhardt, Allen; Paik, Philip Y.; Sudarsan, Arjun; Shenderov, Alex; Hua, Zhishan; Pamula, Vamsee K.

    2010-01-01

    Three innovations address the needs of the medical world with regard to microfluidic manipulation and testing of physiological samples in ways that can benefit point-of-care needs for patients such as premature infants, for which drawing of blood for continuous tests can be life-threatening in their own right, and for expedited results. A chip with sample injection elements, reservoirs (and waste), droplet formation structures, fluidic pathways, mixing areas, and optical detection sites, was fabricated to test the various components of the microfluidic platform, both individually and in integrated fashion. The droplet control system permits a user to control droplet microactuator system functions, such as droplet operations and detector operations. Also, the programming system allows a user to develop software routines for controlling droplet microactuator system functions, such as droplet operations and detector operations. A chip is incorporated into the system with a controller, a detector, input and output devices, and software. A novel filler fluid formulation is used for the transport of droplets with high protein concentrations. Novel assemblies for detection of photons from an on-chip droplet are present, as well as novel systems for conducting various assays, such as immunoassays and PCR (polymerase chain reaction). The lab-on-a-chip (a.k.a., lab-on-a-printed-circuit board) processes physiological samples and comprises a system for automated, multi-analyte measurements using sub-microliter samples of human serum. The invention also relates to a diagnostic chip and system including the chip that performs many of the routine operations of a central labbased chemistry analyzer, integrating, for example, colorimetric assays (e.g., for proteins), chemiluminescence/fluorescence assays (e.g., for enzymes, electrolytes, and gases), and/or conductometric assays (e.g., for hematocrit on plasma and whole blood) on a single chip platform.

  8. New developments in classical chaotic scattering.

    PubMed

    Seoane, Jesús M; Sanjuán, Miguel A F

    2013-01-01

    Classical chaotic scattering is a topic of fundamental interest in nonlinear physics due to the numerous existing applications in fields such as celestial mechanics, atomic and nuclear physics and fluid mechanics, among others. Many new advances in chaotic scattering have been achieved in the last few decades. This work provides a current overview of the field, where our attention has been mainly focused on the most important contributions related to the theoretical framework of chaotic scattering, the fractal dimension, the basins boundaries and new applications, among others. Numerical techniques and algorithms, as well as analytical tools used for its analysis, are also included. We also show some of the experimental setups that have been implemented to study diverse manifestations of chaotic scattering. Furthermore, new theoretical aspects such as the study of this phenomenon in time-dependent systems, different transitions and bifurcations to chaotic scattering and a classification of boundaries in different types according to symbolic dynamics are also shown. Finally, some recent progress on chaotic scattering in higher dimensions is also described. PMID:23242261

  9. New developments in classical chaotic scattering.

    PubMed

    Seoane, Jesús M; Sanjuán, Miguel A F

    2013-01-01

    Classical chaotic scattering is a topic of fundamental interest in nonlinear physics due to the numerous existing applications in fields such as celestial mechanics, atomic and nuclear physics and fluid mechanics, among others. Many new advances in chaotic scattering have been achieved in the last few decades. This work provides a current overview of the field, where our attention has been mainly focused on the most important contributions related to the theoretical framework of chaotic scattering, the fractal dimension, the basins boundaries and new applications, among others. Numerical techniques and algorithms, as well as analytical tools used for its analysis, are also included. We also show some of the experimental setups that have been implemented to study diverse manifestations of chaotic scattering. Furthermore, new theoretical aspects such as the study of this phenomenon in time-dependent systems, different transitions and bifurcations to chaotic scattering and a classification of boundaries in different types according to symbolic dynamics are also shown. Finally, some recent progress on chaotic scattering in higher dimensions is also described.

  10. Chaotic motifs in gene regulatory networks.

    PubMed

    Zhang, Zhaoyang; Ye, Weiming; Qian, Yu; Zheng, Zhigang; Huang, Xuhui; Hu, Gang

    2012-01-01

    Chaos should occur often in gene regulatory networks (GRNs) which have been widely described by nonlinear coupled ordinary differential equations, if their dimensions are no less than 3. It is therefore puzzling that chaos has never been reported in GRNs in nature and is also extremely rare in models of GRNs. On the other hand, the topic of motifs has attracted great attention in studying biological networks, and network motifs are suggested to be elementary building blocks that carry out some key functions in the network. In this paper, chaotic motifs (subnetworks with chaos) in GRNs are systematically investigated. The conclusion is that: (i) chaos can only appear through competitions between different oscillatory modes with rivaling intensities. Conditions required for chaotic GRNs are found to be very strict, which make chaotic GRNs extremely rare. (ii) Chaotic motifs are explored as the simplest few-node structures capable of producing chaos, and serve as the intrinsic source of chaos of random few-node GRNs. Several optimal motifs causing chaos with atypically high probability are figured out. (iii) Moreover, we discovered that a number of special oscillators can never produce chaos. These structures bring some advantages on rhythmic functions and may help us understand the robustness of diverse biological rhythms. (iv) The methods of dominant phase-advanced driving (DPAD) and DPAD time fraction are proposed to quantitatively identify chaotic motifs and to explain the origin of chaotic behaviors in GRNs.

  11. Spread Spectrum Communication with Chaotic Frequency Modulation

    NASA Astrophysics Data System (ADS)

    Volkovskii, Alexander R.; Tsimring, Lev S.; Rulkov, Nikolai F.; Langmore, Ian; Young, Stephen C.

    We describe two different approaches to employ chaotic signals in spread-spectrum (SS) communication systems with phase and frequency modulation. In the first one a chaotic signal is used as a carrier. We demonstrate that using a feedback loop controller, the local chaotic oscillator in the receiver can be synchronized to the transmitter. The information can be transmitted using phase or frequency modulation of the chaotic carrier signal. In the second system the chaotic signal is used for frequency modulation of a voltage controlled oscillator (VCO) to provide a SS signal similar to frequency hopping systems. We show that in a certain parameter range the receiver VCO can be synchronized to the transmitter VCO using a relatively simple phase lock loop (PLL) circuit. The same PLL is used for synchronization of the chaotic oscillators. The information signal can be transmitted using a binary phase shift key (BPSK) or frequency shift key (BFSK) modulation of the frequency modulated carrier signal. Using an experimental circuit operating at radio frequency band and a computer modeling we study the bit error rate (BER) performance in a noisy channel as well as multiuser capability of the system.

  12. Chaotic magnetic fields: Particle motion and energization

    SciTech Connect

    Dasgupta, Brahmananda; Ram, Abhay K.; Li, Gang; Li, Xiaocan

    2014-02-11

    Magnetic field line equations correspond to a Hamiltonian dynamical system, so the features of a Hamiltonian systems can easily be adopted for discussing some essential features of magnetic field lines. The integrability of the magnetic field line equations are discussed by various authors and it can be shown that these equations are, in general, not integrable. We demonstrate several examples of realistic chaotic magnetic fields, produced by asymmetric current configurations. Particular examples of chaotic force-free field and non force-free fields are shown. We have studied, for the first time, the motion of a charged particle in chaotic magnetic fields. It is found that the motion of a charged particle in a chaotic magnetic field is not necessarily chaotic. We also showed that charged particles moving in a time-dependent chaotic magnetic field are energized. Such energization processes could play a dominant role in particle energization in several astrophysical environments including solar corona, solar flares and cosmic ray propagation in space.

  13. Strongly interacting bubbles under an ultrasonic horn.

    PubMed

    Yasui, Kyuichi; Iida, Yasuo; Tuziuti, Toru; Kozuka, Teruyuki; Towata, Atsuya

    2008-01-01

    Numerical simulations of bubble pulsations have been performed for a system of two bubble clouds in order to study the experimentally observed bubble motion under an ultrasonic horn by high-speed video camera. The comparison between the calculated results and the experimental observation of the bubble pulsation has indicated that the bubble pulsation is strongly influenced by the interaction with surrounding bubbles. The expansion of a bubble during the rarefaction phase of ultrasound is strongly reduced by the bubble-bubble interaction. Some bubbles move toward the horn tip due to the secondary Bjerknes force acting from the bubbles near the horn tip. It has also been shown that the acoustic amplitude in the liquid is strongly reduced by cavitation due to the decrease in acoustic radiation resistance.

  14. Micro Bubble Trapping By Acoustic Energy

    NASA Astrophysics Data System (ADS)

    Yoshiki, Yamakoshi

    2005-03-01

    Micro bubble trapping by acoustic energy is a promising technology for a future drug or gene delivery system, because the method can control the bubble dynamics using an applied ultrasonic wave. In this paper, acoustic radiation forces which are applied to the micro bubbles are reviewed as well as their applications for micro bubble manipulation. One of the problems in micro bubble trapping by acoustic energy is that the force applied to the micro bubbles is insufficient for some bubbles. This is severe problem when the bubble has a relatively hard shell. In order to increase the trapping force on the micro bubbles, a novel method is proposed. This method uses seed bubbles in order to manipulate target bubbles.

  15. The bubble legacy

    NASA Astrophysics Data System (ADS)

    Hecht, Jeff

    2010-05-01

    Imagine an optics company - let's call it JDS Uniphase - with a market capitalization approaching the gross domestic product (GDP) of Ireland. Now imagine it merging with a laser company - say, SDL - that has a stock valuation of 41bn, higher than the GDP of Costa Rica. Finally, imagine a start-up with 109m in venture capital in its pocket but no product to its name (Novalux) turning down an offer of 500m as insufficient. It may be hard to believe, but these tales are true: they occurred in the year 2000 - an era when the laser, fibre-optics and photonics industries were the darlings of the financial world. Such was the madcap nature of that brief period that survivors call it simply "the bubble".

  16. Constrained Vapor Bubble

    NASA Technical Reports Server (NTRS)

    Huang, J.; Karthikeyan, M.; Plawsky, J.; Wayner, P. C., Jr.

    1999-01-01

    The nonisothermal Constrained Vapor Bubble, CVB, is being studied to enhance the understanding of passive systems controlled by interfacial phenomena. The study is multifaceted: 1) it is a basic scientific study in interfacial phenomena, fluid physics and thermodynamics; 2) it is a basic study in thermal transport; and 3) it is a study of a heat exchanger. The research is synergistic in that CVB research requires a microgravity environment and the space program needs thermal control systems like the CVB. Ground based studies are being done as a precursor to flight experiment. The results demonstrate that experimental techniques for the direct measurement of the fundamental operating parameters (temperature, pressure, and interfacial curvature fields) have been developed. Fluid flow and change-of-phase heat transfer are a function of the temperature field and the vapor bubble shape, which can be measured using an Image Analyzing Interferometer. The CVB for a microgravity environment, has various thin film regions that are of both basic and applied interest. Generically, a CVB is formed by underfilling an evacuated enclosure with a liquid. Classification depends on shape and Bond number. The specific CVB discussed herein was formed in a fused silica cell with inside dimensions of 3x3x40 mm and, therefore, can be viewed as a large version of a micro heat pipe. Since the dimensions are relatively large for a passive system, most of the liquid flow occurs under a small capillary pressure difference. Therefore, we can classify the discussed system as a low capillary pressure system. The studies discussed herein were done in a 1-g environment (Bond Number = 3.6) to obtain experience to design a microgravity experiment for a future NASA flight where low capillary pressure systems should prove more useful. The flight experiment is tentatively scheduled for the year 2000. The SCR was passed on September 16, 1997. The RDR is tentatively scheduled for October, 1998.

  17. Doughnut-shaped soap bubbles

    NASA Astrophysics Data System (ADS)

    Préve, Deison; Saa, Alberto

    2015-10-01

    Soap bubbles are thin liquid films enclosing a fixed volume of air. Since the surface tension is typically assumed to be the only factor responsible for conforming the soap bubble shape, the realized bubble surfaces are always minimal area ones. Here, we consider the problem of finding the axisymmetric minimal area surface enclosing a fixed volume V and with a fixed equatorial perimeter L . It is well known that the sphere is the solution for V =L3/6 π2 , and this is indeed the case of a free soap bubble, for instance. Surprisingly, we show that for V <α L3/6 π2 , with α ≈0.21 , such a surface cannot be the usual lens-shaped surface formed by the juxtaposition of two spherical caps, but is rather a toroidal surface. Practically, a doughnut-shaped bubble is known to be ultimately unstable and, hence, it will eventually lose its axisymmetry by breaking apart in smaller bubbles. Indisputably, however, the topological transition from spherical to toroidal surfaces is mandatory here for obtaining the global solution for this axisymmetric isoperimetric problem. Our result suggests that deformed bubbles with V <α L3/6 π2 cannot be stable and should not exist in foams, for instance.

  18. Doughnut-shaped soap bubbles.

    PubMed

    Préve, Deison; Saa, Alberto

    2015-10-01

    Soap bubbles are thin liquid films enclosing a fixed volume of air. Since the surface tension is typically assumed to be the only factor responsible for conforming the soap bubble shape, the realized bubble surfaces are always minimal area ones. Here, we consider the problem of finding the axisymmetric minimal area surface enclosing a fixed volume V and with a fixed equatorial perimeter L. It is well known that the sphere is the solution for V=L(3)/6π(2), and this is indeed the case of a free soap bubble, for instance. Surprisingly, we show that for V<αL(3)/6π(2), with α≈0.21, such a surface cannot be the usual lens-shaped surface formed by the juxtaposition of two spherical caps, but is rather a toroidal surface. Practically, a doughnut-shaped bubble is known to be ultimately unstable and, hence, it will eventually lose its axisymmetry by breaking apart in smaller bubbles. Indisputably, however, the topological transition from spherical to toroidal surfaces is mandatory here for obtaining the global solution for this axisymmetric isoperimetric problem. Our result suggests that deformed bubbles with V<αL(3)/6π(2) cannot be stable and should not exist in foams, for instance. PMID:26565252

  19. Applied mathematics of chaotic systems

    SciTech Connect

    Jen, E.; Alber, M.; Camassa, R.; Choi, W.; Crutchfield, J.; Holm, D.; Kovacic, G.; Marsden, J.

    1996-07-01

    This is the final report of a three-year, Laboratory-Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). The objectives of the project were to develop new mathematical techniques for describing chaotic systems and for reexpressing them in forms that can be solved analytically and computationally. The authors focused on global bifurcation analysis of rigid body motion in an ideal incompressible fluid and on an analytical technique for the exact solution of nonlinear cellular automata. For rigid-body motion, they investigated a new completely integrable partial differential equation (PDE) representing model motion of fronts in nematic crystals and studied perturbations of the integrable PDE. For cellular automata with multiple domain structures, the work has included: (1) identification of the associated set of conserved quantities for each type of domain; (2) use of the conserved quantities to construct isomorphism between the nonlinear system and a linear template; and (3) use of exact solvability methods to characterize detailed structure of equilibrium states and to derive bounds for maximal transience times.

  20. Chaotic Scattering and Anomalous Transport

    NASA Astrophysics Data System (ADS)

    Hu, B.; Horton, W.; Petrosky, T.

    2002-11-01

    The non-relativistic classical electron scattering by a fixed ion in a uniform magnetic field exhibits chaotic scattering feature of fractal dependence of the final pitch angle on the impact parameter. We have constructed a discrete map(B. Hu, W. Horton and T. Petrosky, Phys. Rev. E 65, 056212 (2002).) for the region v>> 3.5 × 10^4 B^1/3, where v is the electron velocity in m/s and B is the magnetic field in Tesla. The map agrees quite well with the numerical integration of the equation of motion. For neutron star atmosphere and white dwarf atmosphere, the Debye length and the average distance between ions are much greater than the electron gyroradius, but the deBroglie wavelength is comparable or smaller than the electron gyroradius, thus quantum effect should be considered. We create ensembles for the initial conditions in different parameter regions, and study the transition between the asymptotic states, the distribution of some quantities, e.g., final pitch angles, trapping times and bouncing numbers. We shall also consider multi-ion scattering and transport problem, and search for possible anomalies in the electric resistivity and thermal conductivity.

  1. The role of bubble ascent in magma mixing

    NASA Astrophysics Data System (ADS)

    Wiesmaier, Sebastian; Morgavi, Daniele; Perugini, Diego; De Campos, Cristina; Hess, Kai-Uwe; Lavallée, Yan; Dingwell, Donald B.

    2013-04-01

    . Calculating the normalised variance provides an efficient statistical measure of the diffusion rate of cations at the interface of ambient rhyolite and basaltic plume tail. Bubble ascent provides an efficient mechanism for advection of contrasting melt compositions, independent from Rayleigh-Taylor instabilities [cf. 2], or convection induced by overpressure of rising magma. Interaction of volatile-bearing magmas may thus be enhanced at saturation of one or two end-members by buoyant forces exerted from free fluid phases. Future strategies involve to hone down tolerances in the experimental setup to minimise extraneous bubbles, achieve fluid dynamical constraints on the ascent of bubbles in basalt. [1] De Campos, C., D. Perugini, W. Ertel-Ingrisch, D. Dingwell, and G. Poli (2011), Enhancement of magma mixing efficiency by chaotic dynamics: an experimental study, Contrib. Mineral. Petrol. , 161(6), 863-881. [2] Thomas, N., S. Tait, and T. Koyaguchi (1993), Mixing of stratified liquids by the motion of gas bubbles: application to magma mixing, Earth Planet. Sci. Lett. , 115(1-4), 161-175.

  2. Fuel system bubble dissipation device

    SciTech Connect

    Iseman, W.J.

    1987-11-03

    This patent describes a bubble dissipation device for a fuel system wherein fuel is delivered through a fuel line from a fuel tank to a fuel control with the pressure of the fuel being progressively increased by components including at least one pump stage and an ejector in advance of the pump state. The ejector an ejector casing with a wall defining an elongate tubular flow passage which forms a portion of the fuel line to have all of the fuel flow through the tubular flow passage in flowing from the fuel tank to the fuel control, a nozzle positioned entirely within the tubular flow passage and spaced from the wall to permit fuel flow. The nozzle has an inlet and an outlet with the inlet connected to the pump stage to receive fuel under pressure continuously from the pump stage, a bubble accumulation chamber adjoining and at a level above the ejector casing and operatively connected to the fuel line in advance of the ejector casing. The bubble accumulation chamber is of a size to function as a fuel reservoir and hold an air bubble containing vapor above the level of fuel therein and having an outlet adjacent the bottom thereof operatively connected to the tubular flow passage in the ejector casing at an inlet end, a bubble accumulation chamber inlet above the level of the bubble accumulation chamber outlet whereby fuel can flow through the bubble accumulation chamber from the inlet to the outlet thereof with a bubble in the fuel rising above the fuel level in the bubble accumulation chamber.

  3. Recent Progress of Microfluidics in Translational Applications

    PubMed Central

    Liu, Zongbin; Han, Xin

    2016-01-01

    Microfluidics, featuring microfabricated structures, is a technology for manipulating fluids at the micrometer scale. The small dimension and flexibility of microfluidic systems are ideal for mimicking molecular and cellular microenvironment, and show great potential in translational research and development. Here, the recent progress of microfluidics in biological and biomedical applications, including molecular analysis, cellular analysis, and chip-based material delivery and biomimetic design is presented. The potential future developments in the translational microfluidics field are also discussed. PMID:27091777

  4. Bubble Growth in Lunar Basalts

    NASA Astrophysics Data System (ADS)

    Zhang, Y.

    2009-05-01

    Although Moon is usually said to be volatile-"free", lunar basalts are often vesicular with mm-size bubbles. The vesicular nature of the lunar basalts suggests that they contained some initial gas concentration. A recent publication estimated volatile concentrations in lunar basalts (Saal et al. 2008). This report investigates bubble growth on Moon and compares with that on Earth. Under conditions relevant to lunar basalts, bubble growth in a finite melt shell (i.e., growth of multiple regularly-spaced bubbles) is calculated following Proussevitch and Sahagian (1998) and Liu and Zhang (2000). Initial H2O content of 700 ppm (Saal et al. 2008) or lower is used and the effect of other volatiles (such as carbon dioxide, halogens, and sulfur) is ignored. H2O solubility at low pressures (Liu et al. 2005), concentration-dependent diffusivity in basalt (Zhang and Stolper 1991), and lunar basalt viscosity (Murase and McBirney 1970) are used. Because lunar atmospheric pressure is essentially zero, the confining pressure on bubbles is completely supplied by the overlying magma. Due to low H2O content in lunar basaltic melt (700 ppm H2O corresponds to a saturation pressure of 75 kPa), H2O bubbles only grow in the upper 16 m of a basalt flow or lake. A depth of 20 mm corresponds to a confining pressure of 100 Pa. Hence, vesicular lunar rocks come from very shallow depth. Some findings from the modeling are as follows. (a) Due to low confining pressure as well as low viscosity, even though volatile concentration is very low, bubble growth rate is extremely high, much higher than typical bubble growth rates in terrestrial melts. Hence, mm-size bubbles in lunar basalts are not strange. (b) Because the pertinent pressures are so low, bubble pressure due to surface tension plays a main role in lunar bubble growth, contrary to terrestrial cases. (c) Time scale to reach equilibrium bubble size increases as the confining pressure increases. References: (1) Liu Y, Zhang YX (2000) Earth

  5. Partial coalescence of soap bubbles

    NASA Astrophysics Data System (ADS)

    Harris, Daniel M.; Pucci, Giuseppe; Bush, John W. M.

    2015-11-01

    We present the results of an experimental investigation of the merger of a soap bubble with a planar soap film. When gently deposited onto a horizontal film, a bubble may interact with the underlying film in such a way as to decrease in size, leaving behind a smaller daughter bubble with approximately half the radius of its progenitor. The process repeats up to three times, with each partial coalescence event occurring over a time scale comparable to the inertial-capillary time. Our results are compared to the recent numerical simulations of Martin and Blanchette and to the coalescence cascade of droplets on a fluid bath.

  6. The oscillations of vapor bubbles

    NASA Astrophysics Data System (ADS)

    Prosperetti, Andrea; Yin, Z.; Yang, B.

    2003-04-01

    Bob Apfel had so many interests that it is impossible-however fitting and desirable-to pay homage to his work as a whole. Some of his early studies were devoted to bubble nucleation at high superheats. In the first part of this paper a recent application of this phenomenon is described. Once a vapor bubble is generated, its subsequent oscillations (free and forced) present analogies and differences with those of a gas bubble: the second part of the paper focuses on this topic. [Work supported by NSF and NASA.

  7. The oscillation of vapor bubbles

    NASA Astrophysics Data System (ADS)

    Prosperetti, Andrea; Yin, Zhizhong

    2001-05-01

    Bob Apfel had so many interests that it is impossible-however fitting and desirable-to pay homage to his work as a whole. Some of his early studies were devoted to bubble nucleation at high superheats. In the first part of this paper a recent application of this phenomenon is described. Once a vapor bubble is generated, its subsequent oscillations (free and forced) present analogies and differences with those of a gas bubble: the second part of the paper focuses on this topic. [Work supported by NSF and NASA.

  8. Terminating marine methane bubbles by superhydrophobic sponges.

    PubMed

    Chen, Xiao; Wu, Yuchen; Su, Bin; Wang, Jingming; Song, Yanlin; Jiang, Lei

    2012-11-14

    Marine methane bubbles are absorbed, steadily stored, and continuously transported based on the employment of superhydrophobic sponges. Antiwetting sponges are water-repellent in the atmosphere and absorb gas bubbles under water. Their capacity to store methane bubbles increases with enhanced submerged depth. Significantly, trapped methane bubbles can be continuously transported driven by differential pressure.

  9. Bubble stimulation efficiency of dinoflagellate bioluminescence.

    PubMed

    Deane, Grant B; Stokes, M Dale; Latz, Michael I

    2016-02-01

    Dinoflagellate bioluminescence, a common source of bioluminescence in coastal waters, is stimulated by flow agitation. Although bubbles are anecdotally known to be stimulatory, the process has never been experimentally investigated. This study quantified the flash response of the bioluminescent dinoflagellate Lingulodinium polyedrum to stimulation by bubbles rising through still seawater. Cells were stimulated by isolated bubbles of 0.3-3 mm radii rising at their terminal velocity, and also by bubble clouds containing bubbles of 0.06-10 mm radii for different air flow rates. Stimulation efficiency, the proportion of cells producing a flash within the volume of water swept out by a rising bubble, decreased with decreasing bubble radius for radii less than approximately 1 mm. Bubbles smaller than a critical radius in the range 0.275-0.325 mm did not stimulate a flash response. The fraction of cells stimulated by bubble clouds was proportional to the volume of air in the bubble cloud, with lower stimulation levels observed for clouds with smaller bubbles. An empirical model for bubble cloud stimulation based on the isolated bubble observations successfully reproduced the observed stimulation by bubble clouds for low air flow rates. High air flow rates stimulated more light emission than expected, presumably because of additional fluid shear stress associated with collective buoyancy effects generated by the high air fraction bubble cloud. These results are relevant to bioluminescence stimulation by bubbles in two-phase flows, such as in ship wakes, breaking waves, and sparged bioreactors.

  10. Aspherical bubble dynamics and oscillation times

    SciTech Connect

    Vogel, A.; Noack, J.; Chapyak, E.J.; Godwin, R.P.

    1999-06-01

    The cavitation bubbles common in laser medicine are rarely perfectly spherical and are often located near tissue boundaries, in vessels, etc., which introduce aspherical dynamics. Here, novel features of aspherical bubble dynamics are explored by time-resolved photography and numerical simulations. The growth-collapse period of cylindrical bubbles of large aspect ratio (length:diameter {approximately}20) differs only slightly from twice the Rayleigh collapse time for a spherical bubble with an equivalent maximum volume. This fact justifies using the temporal interval between the acoustic signals emitted upon bubble creation and collapse to estimate the maximum bubble volume. As a result, hydrophone measurements can provide an estimate of the bubble size and energy even for aspherical bubbles. The change of the oscillation period of bubbles near solid walls and elastic (tissue-like) boundaries relative to that of isolated spherical bubbles is also investigated.

  11. Doppler-Based Flow Rate Sensing in Microfluidic Channels

    PubMed Central

    Stern, Liron; Bakal, Avraham; Tzur, Mor; Veinguer, Maya; Mazurski, Noa; Cohen, Nadav; Levy, Uriel

    2014-01-01

    We design, fabricate and experimentally demonstrate a novel generic method to detect flow rates and precise changes of flow velocity in microfluidic devices. Using our method we can measure flow rates of ∼2 mm/s with a resolution of 0.08 mm/s. The operation principle is based on the Doppler shifting of light diffracted from a self-generated periodic array of bubbles within the channel and using self-heterodyne detection to analyze the diffracted light. As such, the device is appealing for variety of “lab on chip” bio-applications where a simple and accurate speed measurement is needed, e.g., for flow-cytometry and cell sorting. PMID:25211195

  12. Optimizing microfluidic ink delivery for dip pen nanolithography

    NASA Astrophysics Data System (ADS)

    Banerjee, Debjyoti; Amro, Nabil A.; Fragala, Joe

    2004-01-01

    This work demonstrates the design optimization, fabrication process development, process optimization and testing of a microfluidic ink delivery apparatus (called "Inkwells") for simultaneously coating an array of DPN pens with different inks. The objective of this work is to deliver between 4 and 10 different inks from reservoirs into appropriately spacd microwell array. A tips of the multi-pen array are coated with different inks by dipping them into the microwell array. The reservoirs, microwells and their connecting micro-channels were etched in silicon wafers using Deep Reactive Ion Etching (DRIE). Fluid actuation was achieved by capillary wicking. The optimum layouts for different applications were selected with respect to the volume requirement of inks, the efficacy of ink-well filling, to obviate the problem of bubble formation, and to test the operations of dipping and writing with a parallel array of pens.

  13. Optimizing microfluidic ink delivery for dip pen nanolithography

    NASA Astrophysics Data System (ADS)

    Banerjee, Debjyoti; Amro, Nabil A.; Fragala, Joe

    2003-12-01

    This work demonstrates the design optimization, fabrication process development, process optimization and testing of a microfluidic ink delivery apparatus (called "Inkwells") for simultaneously coating an array of DPN pens with different inks. The objective of this work is to deliver between 4 and 10 different inks from reservoirs into appropriately spacd microwell array. A tips of the multi-pen array are coated with different inks by dipping them into the microwell array. The reservoirs, microwells and their connecting micro-channels were etched in silicon wafers using Deep Reactive Ion Etching (DRIE). Fluid actuation was achieved by capillary wicking. The optimum layouts for different applications were selected with respect to the volume requirement of inks, the efficacy of ink-well filling, to obviate the problem of bubble formation, and to test the operations of dipping and writing with a parallel array of pens.

  14. Machine vision for digital microfluidics.

    PubMed

    Shin, Yong-Jun; Lee, Jeong-Bong

    2010-01-01

    Machine vision is widely used in an industrial environment today. It can perform various tasks, such as inspecting and controlling production processes, that may require humanlike intelligence. The importance of imaging technology for biological research or medical diagnosis is greater than ever. For example, fluorescent reporter imaging enables scientists to study the dynamics of gene networks with high spatial and temporal resolution. Such high-throughput imaging is increasingly demanding the use of machine vision for real-time analysis and control. Digital microfluidics is a relatively new technology with expectations of becoming a true lab-on-a-chip platform. Utilizing digital microfluidics, only small amounts of biological samples are required and the experimental procedures can be automatically controlled. There is a strong need for the development of a digital microfluidics system integrated with machine vision for innovative biological research today. In this paper, we show how machine vision can be applied to digital microfluidics by demonstrating two applications: machine vision-based measurement of the kinetics of biomolecular interactions and machine vision-based droplet motion control. It is expected that digital microfluidics-based machine vision system will add intelligence and automation to high-throughput biological imaging in the future.

  15. Machine vision for digital microfluidics

    NASA Astrophysics Data System (ADS)

    Shin, Yong-Jun; Lee, Jeong-Bong

    2010-01-01

    Machine vision is widely used in an industrial environment today. It can perform various tasks, such as inspecting and controlling production processes, that may require humanlike intelligence. The importance of imaging technology for biological research or medical diagnosis is greater than ever. For example, fluorescent reporter imaging enables scientists to study the dynamics of gene networks with high spatial and temporal resolution. Such high-throughput imaging is increasingly demanding the use of machine vision for real-time analysis and control. Digital microfluidics is a relatively new technology with expectations of becoming a true lab-on-a-chip platform. Utilizing digital microfluidics, only small amounts of biological samples are required and the experimental procedures can be automatically controlled. There is a strong need for the development of a digital microfluidics system integrated with machine vision for innovative biological research today. In this paper, we show how machine vision can be applied to digital microfluidics by demonstrating two applications: machine vision-based measurement of the kinetics of biomolecular interactions and machine vision-based droplet motion control. It is expected that digital microfluidics-based machine vision system will add intelligence and automation to high-throughput biological imaging in the future.

  16. How does a bubble chamber work?

    SciTech Connect

    Konstantinov, D.; Homsi, W.; Luzuriaga, J.; Su, C.K.; Weilert, M.A.; Maris, H.J.

    1998-11-01

    A charged particle passing through a bubble chamber produces a track of bubbles. The way in which these bubbles are produced has been a matter of some controversy. The authors consider the possibility that in helium and hydrogen bubble chambers the production of bubbles is primarily a mechanical process, rather than a thermal process as has often been assumed. The model the authors propose gives results which are in excellent agreement with experiment.

  17. Smashing Bubbles and Vanishing Sugar.

    ERIC Educational Resources Information Center

    Ward, Alan

    1979-01-01

    Science activities with soap bubbles for primary school children are described in this article. Another activity involves children in determining the whereabouts of sugar as it dissolves in water. (SA)

  18. Partial coalescence of soap bubbles

    NASA Astrophysics Data System (ADS)

    Pucci, G.; Harris, D. M.; Bush, J. W. M.

    2015-06-01

    We present the results of an experimental investigation of the merger of a soap bubble with a planar soap film. When gently deposited onto a horizontal film, a bubble may interact with the underlying film in such a way as to decrease in size, leaving behind a smaller daughter bubble with approximately half the radius of its progenitor. The process repeats up to three times, with each partial coalescence event occurring over a time scale comparable to the inertial-capillary time. Our results are compared to the recent numerical simulations of Martin and Blanchette ["Simulations of surfactant effects on the dynamics of coalescing drops and bubbles," Phys. Fluids 27, 012103 (2015)] and to the coalescence cascade of droplets on a fluid bath.

  19. Magnetism. Blowing magnetic skyrmion bubbles.

    PubMed

    Jiang, Wanjun; Upadhyaya, Pramey; Zhang, Wei; Yu, Guoqiang; Jungfleisch, M Benjamin; Fradin, Frank Y; Pearson, John E; Tserkovnyak, Yaroslav; Wang, Kang L; Heinonen, Olle; te Velthuis, Suzanne G E; Hoffmann, Axel

    2015-07-17

    The formation of soap bubbles from thin films is accompanied by topological transitions. Here we show how a magnetic topological structure, a skyrmion bubble, can be generated in a solid-state system in a similar manner. Using an inhomogeneous in-plane current in a system with broken inversion symmetry, we experimentally "blow" magnetic skyrmion bubbles from a geometrical constriction. The presence of a spatially divergent spin-orbit torque gives rise to instabilities of the magnetic domain structures that are reminiscent of Rayleigh-Plateau instabilities in fluid flows. We determine a phase diagram for skyrmion formation and reveal the efficient manipulation of these dynamically created skyrmions, including depinning and motion. The demonstrated current-driven transformation from stripe domains to magnetic skyrmion bubbles could lead to progress in skyrmion-based spintronics. PMID:26067256

  20. Bubble nucleation in stout beers

    NASA Astrophysics Data System (ADS)

    Lee, W. T.; McKechnie, J. S.; Devereux, M. G.

    2011-05-01

    Bubble nucleation in weakly supersaturated solutions of carbon dioxide—such as champagne, sparkling wines, and carbonated beers—is well understood. Bubbles grow and detach from nucleation sites: gas pockets trapped within hollow cellulose fibers. This mechanism appears not to be active in stout beers that are supersaturated solutions of nitrogen and carbon dioxide. In their canned forms these beers require additional technology (widgets) to release the bubbles which will form the head of the beer. We extend the mathematical model of bubble nucleation in carbonated liquids to the case of two gases and show that this nucleation mechanism is active in stout beers, though substantially slower than in carbonated beers and confirm this by observation. A rough calculation suggests that despite the slowness of the process, applying a coating of hollow porous fibers to the inside of a can or bottle could be a potential replacement for widgets.

  1. Magnetism. Blowing magnetic skyrmion bubbles.

    PubMed

    Jiang, Wanjun; Upadhyaya, Pramey; Zhang, Wei; Yu, Guoqiang; Jungfleisch, M Benjamin; Fradin, Frank Y; Pearson, John E; Tserkovnyak, Yaroslav; Wang, Kang L; Heinonen, Olle; te Velthuis, Suzanne G E; Hoffmann, Axel

    2015-07-17

    The formation of soap bubbles from thin films is accompanied by topological transitions. Here we show how a magnetic topological structure, a skyrmion bubble, can be generated in a solid-state system in a similar manner. Using an inhomogeneous in-plane current in a system with broken inversion symmetry, we experimentally "blow" magnetic skyrmion bubbles from a geometrical constriction. The presence of a spatially divergent spin-orbit torque gives rise to instabilities of the magnetic domain structures that are reminiscent of Rayleigh-Plateau instabilities in fluid flows. We determine a phase diagram for skyrmion formation and reveal the efficient manipulation of these dynamically created skyrmions, including depinning and motion. The demonstrated current-driven transformation from stripe domains to magnetic skyrmion bubbles could lead to progress in skyrmion-based spintronics.

  2. Microfluidic stretchable RF electronics.

    PubMed

    Cheng, Shi; Wu, Zhigang

    2010-12-01

    Stretchable electronics is a revolutionary technology that will potentially create a world of radically different electronic devices and systems that open up an entirely new spectrum of possibilities. This article proposes a microfluidic based solution for stretchable radio frequency (RF) electronics, using hybrid integration of active circuits assembled on flex foils and liquid alloy passive structures embedded in elastic substrates, e.g. polydimethylsiloxane (PDMS). This concept was employed to implement a 900 MHz stretchable RF radiation sensor, consisting of a large area elastic antenna and a cluster of conventional rigid components for RF power detection. The integrated radiation sensor except the power supply was fully embedded in a thin elastomeric substrate. Good electrical performance of the standalone stretchable antenna as well as the RF power detection sub-module was verified by experiments. The sensor successfully detected the RF radiation over 5 m distance in the system demonstration. Experiments on two-dimensional (2D) stretching up to 15%, folding and twisting of the demonstrated sensor were also carried out. Despite the integrated device was severely deformed, no failure in RF radiation sensing was observed in the tests. This technique illuminates a promising route of realizing stretchable and foldable large area integrated RF electronics that are of great interest to a variety of applications like wearable computing, health monitoring, medical diagnostics, and curvilinear electronics.

  3. Microfluidic Compartmentalized Directed Evolution

    PubMed Central

    Paegel, Brian M.; Joyce, Gerald F.

    2010-01-01

    Summary Directed evolution studies often make use of water-in-oil compartments, which conventionally are prepared by bulk emulsification, a crude process that generates non-uniform droplets and can damage biochemical reagents. A microfluidic emulsification circuit was devised that generates uniform water-in-oil droplets (21.9 ± 0.8 μm radius) with high throughput (107–108 droplets per hour). The circuit contains a radial array of aqueous flow nozzles that intersect a surrounding oil flow channel. This device was used to evolve RNA enzymes with RNA ligase activity, selecting enzymes that could resist inhibition by neomycin. Each molecule in the population had the opportunity to undergo 108-fold selective amplification within its respective compartment. Then the progeny RNAs were harvested and used to seed new compartments. During five rounds of this procedure, the enzymes acquired mutations that conferred resistance to neomycin and caused some enzymes to become dependent on neomycin for optimal activity. PMID:20659684

  4. Bubbles in a freshwater lake.

    PubMed

    Thorpe, S A; Stubbs, A R

    1979-05-31

    WHEN the wind is strong enough to produce whitecaps on Loch Ness, patchy 'clouds' of acoustic reflectors are detected well below the surface, the depth to which they penetrate increasing with wind speed (Fig. 1). No seasonal variation in the occurrence of the reflectors has been detected. A biological explanation is therefore discounted and we suggest here that they are bubbles caused by waves breaking and forming whitecaps in deep water. Similar bubble clouds may occur in other lakes and in the sea.

  5. Bubble gum simulating abdominal calcifications.

    PubMed

    Geller, E; Smergel, E M

    1992-01-01

    CT examination of the abdomens of two children demonstrated sites of high attenuation in the stomach, which were revealed to be bubble gum. Investigation of the CT appearance of samples of chewing gum showed that it consistently has high attenuation (178-345 HU). The attenuation of gum base, which contains calcium carbonate, was 476 HU. In addition, examination of a volunteer who had swallowed bubble gum confirmed the CT appearance. PMID:1523059

  6. Imaging Liquids Using Microfluidic Cells

    SciTech Connect

    Yu, Xiao-Ying; Liu, Bingwen; Yang, Li

    2013-05-10

    Chemistry occurring in the liquid and liquid surface is important in many applications. Chemical imaging of liquids using vacuum based analytical techniques is challenging due to the difficulty in working with liquids with high volatility. Recent development in microfluidics enabled and increased our capabilities to study liquid in situ using surface sensitive techniques such as electron microscopy and spectroscopy. Due to its small size, low cost, and flexibility in design, liquid cells based on microfluidics have been increasingly used in studying and imaging complex phenomena involving liquids. This paper presents a review of microfluidic cells that were developed to adapt to electron microscopes and various spectrometers for in situ chemical analysis and imaging of liquids. The following topics will be covered including cell designs, fabrication techniques, unique technical features for vacuum compatible cells, and imaging with electron microscopy and spectroscopy. Challenges are summarized and recommendations for future development priority are proposed.

  7. 3D-Printed Microfluidics.

    PubMed

    Au, Anthony K; Huynh, Wilson; Horowitz, Lisa F; Folch, Albert

    2016-03-14

    The advent of soft lithography allowed for an unprecedented expansion in the field of microfluidics. However, the vast majority of PDMS microfluidic devices are still made with extensive manual labor, are tethered to bulky control systems, and have cumbersome user interfaces, which all render commercialization difficult. On the other hand, 3D printing has begun to embrace the range of sizes and materials that appeal to the developers of microfluidic devices. Prior to fabrication, a design is digitally built as a detailed 3D CAD file. The design can be assembled in modules by remotely collaborating teams, and its mechanical and fluidic behavior can be simulated using finite-element modeling. As structures are created by adding materials without the need for etching or dissolution, processing is environmentally friendly and economically efficient. We predict that in the next few years, 3D printing will replace most PDMS and plastic molding techniques in academia.

  8. From determinism and probability to chaos: chaotic evolution towards philosophy and methodology of chaotic optimization.

    PubMed

    Pei, Yan

    2015-01-01

    We present and discuss philosophy and methodology of chaotic evolution that is theoretically supported by chaos theory. We introduce four chaotic systems, that is, logistic map, tent map, Gaussian map, and Hénon map, in a well-designed chaotic evolution algorithm framework to implement several chaotic evolution (CE) algorithms. By comparing our previous proposed CE algorithm with logistic map and two canonical differential evolution (DE) algorithms, we analyse and discuss optimization performance of CE algorithm. An investigation on the relationship between optimization capability of CE algorithm and distribution characteristic of chaotic system is conducted and analysed. From evaluation result, we find that distribution of chaotic system is an essential factor to influence optimization performance of CE algorithm. We propose a new interactive EC (IEC) algorithm, interactive chaotic evolution (ICE) that replaces fitness function with a real human in CE algorithm framework. There is a paired comparison-based mechanism behind CE search scheme in nature. A simulation experimental evaluation is conducted with a pseudo-IEC user to evaluate our proposed ICE algorithm. The evaluation result indicates that ICE algorithm can obtain a significant better performance than or the same performance as interactive DE. Some open topics on CE, ICE, fusion of these optimization techniques, algorithmic notation, and others are presented and discussed.

  9. Microfluidic manufacture of rt-PA -loaded echogenic liposomes.

    PubMed

    Kandadai, Madhuvanthi A; Mukherjee, Prithviraj; Shekhar, Himanshu; Shaw, George J; Papautsky, Ian; Holland, Christy K

    2016-06-01

    Echogenic liposomes (ELIP), loaded with recombinant tissue-type plasminogen activator (rt-PA) and microbubbles that act as cavitation nuclei, are under development for ultrasound-mediated thrombolysis. Conventional manufacturing techniques produce a polydisperse rt-PA-loaded ELIP population with only a small percentage of particles containing microbubbles. Further, a polydisperse population of rt-PA-loaded ELIP has a broadband frequency response with complex bubble dynamics when exposed to pulsed ultrasound. In this work, a microfluidic flow-focusing device was used to generate monodisperse rt-PA-loaded ELIP (μtELIP) loaded with a perfluorocarbon gas. The rt-PA associated with the μtELIP was encapsulated within the lipid shell as well as intercalated within the lipid shell. The μtELIP had a mean diameter of 5 μm, a resonance frequency of 2.2 MHz, and were found to be stable for at least 30 min in 0.5 % bovine serum albumin. Additionally, 35 % of μtELIP particles were estimated to contain microbubbles, an order of magnitude higher than that reported previously for batch-produced rt-PA-loaded ELIP. These findings emphasize the advantages offered by microfluidic techniques for improving the encapsulation efficiency of both rt-PA and perflurocarbon microbubbles within echogenic liposomes. PMID:27206512

  10. Enhancing defect tolerance in periodic post microfluidic channels

    NASA Astrophysics Data System (ADS)

    Chapman, Glenn H.; Gray, Bonnie L.

    2016-03-01

    Biomedical sensors using microfluidic channels are prone to blockage due to particles and bubbles in the fluid. Wider channels may be used, but wide polymer channels may suffer from structural instability (e.g., sagging channel covers). A common design uses many parallel flow channels separated by structural support walls, but these can be rapidly blocked by particulates. We have been studying an alternative "Cathedral Chamber" design where the channel "roof" (cover) is support by periodic posts which creates many possible flow paths to bypass blockages. We use Monte Carlo modelling with iterative COMSOL fluid dynamics simulations to establish the stream lines, and particle velocities. Then a rules based methodology iteratively places trapped particles based on the fluid paths created by the existing blockages, until the system become fully blocked. Previous work has shown that the periodic post design increases lifetime by allowing 6 to 7 times more blockages than can a parallel channel design. In this paper, we simulate and analyze why expanding the number of channels increases almost linearly the number of particles required for blockages. Lifetime increase is still 4.5-5.5 times even for the limiting case of a 2 channel cathedral chamber. This shows the sideways flow created by the periodic posts creates many advantages for the microfluidic chambers.

  11. Microfluidic manufacture of rt-PA -loaded echogenic liposomes.

    PubMed

    Kandadai, Madhuvanthi A; Mukherjee, Prithviraj; Shekhar, Himanshu; Shaw, George J; Papautsky, Ian; Holland, Christy K

    2016-06-01

    Echogenic liposomes (ELIP), loaded with recombinant tissue-type plasminogen activator (rt-PA) and microbubbles that act as cavitation nuclei, are under development for ultrasound-mediated thrombolysis. Conventional manufacturing techniques produce a polydisperse rt-PA-loaded ELIP population with only a small percentage of particles containing microbubbles. Further, a polydisperse population of rt-PA-loaded ELIP has a broadband frequency response with complex bubble dynamics when exposed to pulsed ultrasound. In this work, a microfluidic flow-focusing device was used to generate monodisperse rt-PA-loaded ELIP (μtELIP) loaded with a perfluorocarbon gas. The rt-PA associated with the μtELIP was encapsulated within the lipid shell as well as intercalated within the lipid shell. The μtELIP had a mean diameter of 5 μm, a resonance frequency of 2.2 MHz, and were found to be stable for at least 30 min in 0.5 % bovine serum albumin. Additionally, 35 % of μtELIP particles were estimated to contain microbubbles, an order of magnitude higher than that reported previously for batch-produced rt-PA-loaded ELIP. These findings emphasize the advantages offered by microfluidic techniques for improving the encapsulation efficiency of both rt-PA and perflurocarbon microbubbles within echogenic liposomes.

  12. Integrated temperature measurement and control in polymer microfluidic systems

    NASA Astrophysics Data System (ADS)

    Kimball, Christopher Robert

    Methods for integrating electrical components in low cost polymer microfluidic systems are presented. These methods include deposition and photolithographic patterning of thin-film metal layers on polycarbonate and poly(methyl methacrylate), and the embedding of pre-fabricated and diced chips. The design and performance of Resistive Temperature Detectors (RTDs) fabricated with these methods is also discussed. The fabrication and testing of two polymer microfluidic systems is presented. The first system contains a two-dimensional array of RTDs in a microchannel capable of measuring the temperature distribution within the fluid. The second system employs Temperature Gradient Gel Electrophoresis (TGGE) for the detection of mutations in DNA samples. A compact mathematical model of the thermal effects caused by an integrated microheater is presented and validated with experimental measurements. This model may be applied to a wide variety of polymer microsystems which contain heaters and/or temperature sensors. The design of bubble pumps, hot plate chemical sensors, temperature gradient gel/capillary electrophoresis systems, flow sensors, etc. will be aided by this model.

  13. Microfluidic manufacture of rt-PA-loaded echogenic liposomes

    PubMed Central

    Kandadai, Madhuvanthi A.; Mukherjee, Prithviraj; Shekhar, Himanshu; Shaw, George J.; Papautsky, Ian; Holland, Christy K.

    2016-01-01

    Echogenic liposomes (ELIP), loaded with recombinant tissue-type plasminogen activator (rt-PA) and microbubbles that act as cavitation nuclei, are under development for ultrasound-mediated thrombolysis. Conventional manufacturing techniques produce a polydisperse rt-PA-loaded ELIP population with only a small percentage of particles containing microbubbles. Further, a polydisperse population of rt-PA-loaded ELIP has a broadband frequency response with complex bubble dynamics when exposed to pulsed ultrasound. In this work, a microfluidic flow-focusing device was used to generate monodisperse rt-PA-loaded ELIP (µtELIP) loaded with a perfluorocarbon gas. The rt-PA associated with the µtELIP was encapsulated within the lipid shell as well as intercalated within the lipid shell. The µtELIP had a mean diameter of 5 µm, a resonance frequency of 2.2 MHz, and were found to be stable for at least 30 min in 0.5%bovine serum albumin. Additionally, 35 % of µtELIP particles were estimated to contain microbubbles, an order of magnitude higher than that reported previously for batch-produced rt-PA-loaded ELIP. These findings emphasize the advantages offered by microfluidic techniques for improving the encapsulation efficiency of both rt-PA and perflurocarbon microbubbles within echogenic liposomes. PMID:27206512

  14. Controlled transitions between cupolets of chaotic systems

    NASA Astrophysics Data System (ADS)

    Morena, Matthew A.; Short, Kevin M.; Cooke, Erica E.

    2014-03-01

    We present an efficient control scheme that stabilizes the unstable periodic orbits of a chaotic system. The resulting orbits are known as cupolets and collectively provide an important skeleton for the dynamical system. Cupolets exhibit the interesting property that a given sequence of controls will uniquely identify a cupolet, regardless of the system's initial state. This makes it possible to transition between cupolets, and thus unstable periodic orbits, simply by switching control sequences. We demonstrate that although these transitions require minimal controls, they may also involve significant chaotic transients unless carefully controlled. As a result, we present an effective technique that relies on Dijkstra's shortest path algorithm from algebraic graph theory to minimize the transients and also to induce certainty into the control of nonlinear systems, effectively providing an efficient algorithm for the steering and targeting of chaotic systems.

  15. An investigation of chaotic Kolmogorov flows

    NASA Technical Reports Server (NTRS)

    Platt, N.; Sirovich, L.; Fitzmaurice, N.

    1991-01-01

    A two dimensional flow governed by the incompressible Navier-Stokes equations with a steady spatially periodic forcing (known as the Kolmogorov flow) is numerically simulated. The behavior of the flow and its transition states as the Reynolds number (Re) varies is investigated in detail, as well as a number of the flow features. A sequence of bifurcations is shown to take place in the flow as Re varied. Two main regimes of the flow were observed: small and large scale structure regimes corresponding to different ranges of Re. Each of the regimes includes a number of quasiperiodic, chaotic, and relaminarization windows. In addition, each range contains a chaotic window with non-ergodic chaotic attractors. Spatially disordered, but temporally steady states were discovered in large scale structure regime. Features of the diverse cases are displayed in terms of the temporal power spectrum, Poincare sections and, where possible, Lyapunov exponents and Kaplan-Yorke dimension.

  16. Desktop chaotic systems: Intuition and visualization

    NASA Technical Reports Server (NTRS)

    Bright, Michelle M.; Melcher, Kevin J.; Qammar, Helen K.; Hartley, Tom T.

    1993-01-01

    This paper presents a dynamic study of the Wildwood Pendulum, a commercially available desktop system which exhibits a strange attractor. The purpose of studying this chaotic pendulum is twofold: to gain insight in the paradigmatic approach of modeling, simulating, and determining chaos in nonlinear systems; and to provide a desktop model of chaos as a visual tool. For this study, the nonlinear behavior of this chaotic pendulum is modeled, a computer simulation is performed, and an experimental performance is measured. An assessment of the pendulum in the phase plane shows the strange attractor. Through the use of a box-assisted correlation dimension methodology, the attractor dimension is determined for both the model and the experimental pendulum systems. Correlation dimension results indicate that the pendulum and the model are chaotic and their fractal dimensions are similar.

  17. An investigation of chaotic Kolmogorov flows

    NASA Technical Reports Server (NTRS)

    Platt, N.; Sirovich, L.; Fitzmaurice, N.

    1990-01-01

    A two dimensional flow governed by the incompressible Navier-Stokes equations with a steady spatially periodic forcing (known as the Kolmogorov flow) is numerically simulated. The behavior of the flow and its transition states as the Reynolds number (Re) varies is investigated in detail, as well as a number of the flow features. A sequence of bifurcations is shown to take place in the flow as Re varied. Two main regimes of the flow were observed: small and large scale structure regimes corresponding to different ranges of Re. Each of the regimes includes a number of quasiperiodic, chaotic, and relaminarization windows. In addition, each range contains a chaotic window with non-ergodic chaotic attractors. Spatially disordered, but temporally steady states were discovered in large scale structure regime. Features of the diverse cases are displayed in terms of the temporal power spectrum, Poincare sections and, where possible, Lyapunov exponents and Kaplan-Yorke dimension.

  18. Controlled transitions between cupolets of chaotic systems.

    PubMed

    Morena, Matthew A; Short, Kevin M; Cooke, Erica E

    2014-03-01

    We present an efficient control scheme that stabilizes the unstable periodic orbits of a chaotic system. The resulting orbits are known as cupolets and collectively provide an important skeleton for the dynamical system. Cupolets exhibit the interesting property that a given sequence of controls will uniquely identify a cupolet, regardless of the system's initial state. This makes it possible to transition between cupolets, and thus unstable periodic orbits, simply by switching control sequences. We demonstrate that although these transitions require minimal controls, they may also involve significant chaotic transients unless carefully controlled. As a result, we present an effective technique that relies on Dijkstra's shortest path algorithm from algebraic graph theory to minimize the transients and also to induce certainty into the control of nonlinear systems, effectively providing an efficient algorithm for the steering and targeting of chaotic systems.

  19. Controlled transitions between cupolets of chaotic systems

    SciTech Connect

    Morena, Matthew A. Short, Kevin M.; Cooke, Erica E.

    2014-03-15

    We present an efficient control scheme that stabilizes the unstable periodic orbits of a chaotic system. The resulting orbits are known as cupolets and collectively provide an important skeleton for the dynamical system. Cupolets exhibit the interesting property that a given sequence of controls will uniquely identify a cupolet, regardless of the system's initial state. This makes it possible to transition between cupolets, and thus unstable periodic orbits, simply by switching control sequences. We demonstrate that although these transitions require minimal controls, they may also involve significant chaotic transients unless carefully controlled. As a result, we present an effective technique that relies on Dijkstra's shortest path algorithm from algebraic graph theory to minimize the transients and also to induce certainty into the control of nonlinear systems, effectively providing an efficient algorithm for the steering and targeting of chaotic systems.

  20. Chaotic signal processes and associated nonlinear filters

    NASA Astrophysics Data System (ADS)

    McCarty, Robert C.

    1997-04-01

    A chaotic signal process is generated by use of a continuous but nowhere differentiable Weierstrass function as a force function in Duffing's second-order nonlinear differential equation. In the particular cases where Duffing's equation represents the mechanical behavior of a simple pendulum where only the mass of the 'bob' changes in time, an analytical solution is obtained by the use of Hammerstein integrals. In the more-complicated case where the mass of the 'bob' and the length of the pendulum rod are both changing in time, the resulting solution is obtained numerically. In any detailed analysis of a chaotic signal process, nonlinear filters are used to determine the existence and nature of an attractor or repeller as discussed. By a simple change of parametric values in the Weierstrass function, other chaotic signal processes are easily generated.

  1. Bubble-Pen Lithography.

    PubMed

    Lin, Linhan; Peng, Xiaolei; Mao, Zhangming; Li, Wei; Yogeesh, Maruthi N; Rajeeva, Bharath Bangalore; Perillo, Evan P; Dunn, Andrew K; Akinwande, Deji; Zheng, Yuebing

    2016-01-13

    Current lithography techniques, which employ photon, electron, or ion beams to induce chemical or physical reactions for micro/nano-fabrication, have remained challenging in patterning chemically synthesized colloidal particles, which are emerging as building blocks for functional devices. Herein, we develop a new technique - bubble-pen lithography (BPL) - to pattern colloidal particles on substrates using optically controlled microbubbles. Briefly, a single laser beam generates a microbubble at the interface of colloidal suspension and a plasmonic substrate via plasmon-enhanced photothermal effects. The microbubble captures and immobilizes the colloidal particles on the substrate through coordinated actions of Marangoni convection, surface tension, gas pressure, and substrate adhesion. Through directing the laser beam to move the microbubble, we create arbitrary single-particle patterns and particle assemblies with different resolutions and architectures. Furthermore, we have applied BPL to pattern CdSe/ZnS quantum dots on plasmonic substrates and polystyrene (PS) microparticles on two-dimensional (2D) atomic-layer materials. With the low-power operation, arbitrary patterning and applicability to general colloidal particles, BPL will find a wide range of applications in microelectronics, nanophotonics, and nanomedicine.

  2. A "twisted" microfluidic mixer suitable for a wide range of flow rate applications.

    PubMed

    Sivashankar, Shilpa; Agambayev, Sumeyra; Mashraei, Yousof; Li, Er Qiang; Thoroddsen, Sigurdur T; Salama, Khaled Nabil

    2016-05-01

    This paper proposes a new "twisted" 3D microfluidic mixer fabricated by a laser writing/microfabrication technique. Effective and efficient mixing using the twisted micromixers can be obtained by combining two general chaotic mixing mechanisms: splitting/recombining and chaotic advection. The lamination of mixer units provides the splitting and recombination mechanism when the quadrant of circles is arranged in a two-layered serial arrangement of mixing units. The overall 3D path of the microchannel introduces the advection. An experimental investigation using chemical solutions revealed that these novel 3D passive microfluidic mixers were stable and could be operated at a wide range of flow rates. This micromixer finds application in the manipulation of tiny volumes of liquids that are crucial in diagnostics. The mixing performance was evaluated by dye visualization, and using a pH test that determined the chemical reaction of the solutions. A comparison of the tornado-mixer with this twisted micromixer was made to evaluate the efficiency of mixing. The efficiency of mixing was calculated within the channel by acquiring intensities using ImageJ software. Results suggested that efficient mixing can be obtained when more than 3 units were consecutively placed. The geometry of the device, which has a length of 30 mm, enables the device to be integrated with micro total analysis systems and other lab-on-chip devices.

  3. A “twisted” microfluidic mixer suitable for a wide range of flow rate applications

    PubMed Central

    Sivashankar, Shilpa; Agambayev, Sumeyra; Mashraei, Yousof; Li, Er Qiang; Thoroddsen, Sigurdur T.; Salama, Khaled Nabil

    2016-01-01

    This paper proposes a new “twisted” 3D microfluidic mixer fabricated by a laser writing/microfabrication technique. Effective and efficient mixing using the twisted micromixers can be obtained by combining two general chaotic mixing mechanisms: splitting/recombining and chaotic advection. The lamination of mixer units provides the splitting and recombination mechanism when the quadrant of circles is arranged in a two-layered serial arrangement of mixing units. The overall 3D path of the microchannel introduces the advection. An experimental investigation using chemical solutions revealed that these novel 3D passive microfluidic mixers were stable and could be operated at a wide range of flow rates. This micromixer finds application in the manipulation of tiny volumes of liquids that are crucial in diagnostics. The mixing performance was evaluated by dye visualization, and using a pH test that determined the chemical reaction of the solutions. A comparison of the tornado-mixer with this twisted micromixer was made to evaluate the efficiency of mixing. The efficiency of mixing was calculated within the channel by acquiring intensities using ImageJ software. Results suggested that efficient mixing can be obtained when more than 3 units were consecutively placed. The geometry of the device, which has a length of 30 mm, enables the device to be integrated with micro total analysis systems and other lab-on-chip devices. PMID:27453767

  4. A "twisted" microfluidic mixer suitable for a wide range of flow rate applications.

    PubMed

    Sivashankar, Shilpa; Agambayev, Sumeyra; Mashraei, Yousof; Li, Er Qiang; Thoroddsen, Sigurdur T; Salama, Khaled Nabil

    2016-05-01

    This paper proposes a new "twisted" 3D microfluidic mixer fabricated by a laser writing/microfabrication technique. Effective and efficient mixing using the twisted micromixers can be obtained by combining two general chaotic mixing mechanisms: splitting/recombining and chaotic advection. The lamination of mixer units provides the splitting and recombination mechanism when the quadrant of circles is arranged in a two-layered serial arrangement of mixing units. The overall 3D path of the microchannel introduces the advection. An experimental investigation using chemical solutions revealed that these novel 3D passive microfluidic mixers were stable and could be operated at a wide range of flow rates. This micromixer finds application in the manipulation of tiny volumes of liquids that are crucial in diagnostics. The mixing performance was evaluated by dye visualization, and using a pH test that determined the chemical reaction of the solutions. A comparison of the tornado-mixer with this twisted micromixer was made to evaluate the efficiency of mixing. The efficiency of mixing was calculated within the channel by acquiring intensities using ImageJ software. Results suggested that efficient mixing can be obtained when more than 3 units were consecutively placed. The geometry of the device, which has a length of 30 mm, enables the device to be integrated with micro total analysis systems and other lab-on-chip devices. PMID:27453767

  5. Using unstable periodic orbits to overcome distortion in chaotic signals.

    PubMed

    Carroll, T L

    1999-11-01

    Proposals to use chaos for communications have been hindered by the fact that broadband chaotic signals are distorted by narrow band or frequency dependent communications channels. I show in this paper how the unstable periodic orbits from a chaotic attractor may be used to estimate the parameters of a filter that has acted on a signal from that attractor and estimate the chaotic signal, even when additive noise larger than the chaotic signal is present. PMID:11970420

  6. Microfluidic devices for droplet injection

    NASA Astrophysics Data System (ADS)

    Aubrecht, Donald; Akartuna, Ilke; Weitz, David

    2012-02-01

    As picoliter-scale reaction vessels, microfluidic water-in-oil emulsions have found application for high-throughput, large-sample number analyses. Often, the biological or chemical system under investigation needs to be encapsulated into droplets to prevent cross contamination prior to the introduction of reaction reagents. Previous techniques of picoinjection or droplet synchronization and merging enable the addition of reagents to individual droplets, but present limitations on what can be added to each droplet. We present microfluidic devices that couple the strengths of picoinjection and droplet merging, allowing us to selectively add precise volume to our droplet reactions.

  7. Microfluidic device for drug delivery

    NASA Technical Reports Server (NTRS)

    Beebe, David J. (Inventor); MacDonald, Michael J. (Inventor); Eddington, David T. (Inventor); Mensing, Glennys A. (Inventor)

    2010-01-01

    A microfluidic device is provided for delivering a drug to an individual. The microfluidic device includes a body that defines a reservoir for receiving the drug therein. A valve interconnects the reservoir to an output needle that is insertable into the skin of an individual. A pressure source urges the drug from the reservoir toward the needle. The valve is movable between a closed position preventing the flow of the drug from the reservoir to the output needle and an open position allowing for the flow of the drug from the reservoir to the output needle in response to a predetermined condition in the physiological fluids of the individual.

  8. Building functional materials for health care and pharmacy from microfluidic principles and Flow Focusing.

    PubMed

    Gañán-Calvo, A M; Montanero, J M; Martín-Banderas, L; Flores-Mosquera, M

    2013-11-01

    In this review, we aim at establishing a relationship between the fundamentals of the microfluidics technologies used in the Pharmacy field, and the achievements accomplished by those technologies. We describe the main methods for manufacturing micrometer drops, bubbles, and capsules, as well as the corresponding underlying physical mechanisms. In this regard, the review is intended to show non-specialist readers the dynamical processes which determine the success of microfluidics techniques. Flow focusing (FF) is a droplet-based method widely used to produce different types of fluid entities on a continuous basis by applying an extensional co-flow. We take this technique as an example to illustrate how microfluidics technologies for drug delivery are progressing from a deep understanding of the physics of fluids involved. Specifically, we describe the limitations of FF, and review novel methods which enhance its stability and robustness. In the last part of this paper, we review some of the accomplishments of microfluidics when it comes to drug manufacturing and delivery. Special attention is paid to the production of the microencapsulated form because this fluidic structure gathers the main functionalities sought for in Pharmacy. We also show how FF has been adapted to satisfy an ample variety of pharmaceutical requirements to date. PMID:23954401

  9. Building functional materials for health care and pharmacy from microfluidic principles and Flow Focusing.

    PubMed

    Gañán-Calvo, A M; Montanero, J M; Martín-Banderas, L; Flores-Mosquera, M

    2013-11-01

    In this review, we aim at establishing a relationship between the fundamentals of the microfluidics technologies used in the Pharmacy field, and the achievements accomplished by those technologies. We describe the main methods for manufacturing micrometer drops, bubbles, and capsules, as well as the corresponding underlying physical mechanisms. In this regard, the review is intended to show non-specialist readers the dynamical processes which determine the success of microfluidics techniques. Flow focusing (FF) is a droplet-based method widely used to produce different types of fluid entities on a continuous basis by applying an extensional co-flow. We take this technique as an example to illustrate how microfluidics technologies for drug delivery are progressing from a deep understanding of the physics of fluids involved. Specifically, we describe the limitations of FF, and review novel methods which enhance its stability and robustness. In the last part of this paper, we review some of the accomplishments of microfluidics when it comes to drug manufacturing and delivery. Special attention is paid to the production of the microencapsulated form because this fluidic structure gathers the main functionalities sought for in Pharmacy. We also show how FF has been adapted to satisfy an ample variety of pharmaceutical requirements to date.

  10. FEASTING BLACK HOLE BLOWS BUBBLES

    NASA Technical Reports Server (NTRS)

    2002-01-01

    A monstrous black hole's rude table manners include blowing huge bubbles of hot gas into space. At least, that's the gustatory practice followed by the supermassive black hole residing in the hub of the nearby galaxy NGC 4438. Known as a peculiar galaxy because of its unusual shape, NGC 4438 is in the Virgo Cluster, 50 million light-years from Earth. These NASA Hubble Space Telescope images of the galaxy's central region clearly show one of the bubbles rising from a dark band of dust. The other bubble, emanating from below the dust band, is barely visible, appearing as dim red blobs in the close-up picture of the galaxy's hub (the colorful picture at right). The background image represents a wider view of the galaxy, with the central region defined by the white box. These extremely hot bubbles are caused by the black hole's voracious eating habits. The eating machine is engorging itself with a banquet of material swirling around it in an accretion disk (the white region below the bright bubble). Some of this material is spewed from the disk in opposite directions. Acting like high-powered garden hoses, these twin jets of matter sweep out material in their paths. The jets eventually slam into a wall of dense, slow-moving gas, which is traveling at less than 223,000 mph (360,000 kph). The collision produces the glowing material. The bubbles will continue to expand and will eventually dissipate. Compared with the life of the galaxy, this bubble-blowing phase is a short-lived event. The bubble is much brighter on one side of the galaxy's center because the jet smashed into a denser amount of gas. The brighter bubble is 800 light-years tall and 800 light-years across. The observations are being presented June 5 at the American Astronomical Society meeting in Rochester, N.Y. Both pictures were taken March 24, 1999 with the Wide Field and Planetary Camera 2. False colors were used to enhance the details of the bubbles. The red regions in the picture denote the hot gas

  11. Will Quantum Cosmology Resurrect Chaotic Inflation Model?

    NASA Astrophysics Data System (ADS)

    Kim, Sang Pyo; Kim, Won

    2016-07-01

    The single field chaotic inflation model with a monomial power greater than one seems to be ruled out by the recent Planck and WMAP CMB data while Starobinsky model with a higher curvature term seems to be a viable model. Higher curvature terms being originated from quantum fluctuations, we revisit the quantum cosmology of the Wheeler-DeWitt equation for the chaotic inflation model. The semiclassical cosmology emerges from quantum cosmology with fluctuations of spacetimes and matter when the wave function is peaked around the semiclassical trajectory with quantum corrections a la the de Broglie-Bohm pilot theory.

  12. Synchronization regimes in conjugate coupled chaotic oscillators.

    PubMed

    Karnatak, Rajat; Ramaswamy, Ram; Prasad, Awadhesh

    2009-09-01

    Nonlinear oscillators that are mutually coupled via dissimilar (or conjugate) variables display distinct regimes of synchronous behavior. In identical chaotic oscillators diffusively coupled in this manner, complete synchronization occurs only by chaos suppression when the coupled subsystems drive each other into a regime of periodic dynamics. Furthermore, the coupling does not vanish but acts as an "internal" drive. When the oscillators are mismatched, phase synchronization occurs, while in a master slave configuration, generalized synchrony results. These effects are demonstrated in a system of coupled chaotic Rossler oscillators.

  13. A class of chaotic bird calls?

    PubMed

    Fletcher, N H

    2000-08-01

    Evidence is presented that the basic vocalized sound produced by some cockatoos, specifically the Australian sulfur-crested cockatoo (Cacatua galerita) and the gang-gang cockatoo (Callocephalon fimbriatum), has a chaotic acoustic structure rather than the harmonic structure characteristic of most birdsongs. These findings support those of Fee et al. [Nature (London) 395(3), 67-71 (1999)] on nonlinear period-doubling transitions in the song of the zebra finch (Taeniopygia guttata). It is suggested that syllables with chaotic structure may be a feature of the songs of many birds.

  14. Fractal dimension in nonhyperbolic chaotic scattering

    NASA Technical Reports Server (NTRS)

    Lau, Yun-Tung; Finn, John M.; Ott, Edward

    1991-01-01

    In chaotic scattering there is a Cantor set of input-variable values of zero Lebesgue measure (i.e., zero total length) on which the scattering function is singular. For cases where the dynamics leading to chaotic scattering is nonhyperbolic (e.g., there are Kolmogorov-Arnol'd-Moser tori), the nature of this singular set is fundamentally different from that in the hyperbolic case. In particular, for the nonhyperbolic case, although the singular set has zero total length, strong evidence is presented to show that its fractal dimension is 1.

  15. A class of chaotic bird calls?

    PubMed

    Fletcher, N H

    2000-08-01

    Evidence is presented that the basic vocalized sound produced by some cockatoos, specifically the Australian sulfur-crested cockatoo (Cacatua galerita) and the gang-gang cockatoo (Callocephalon fimbriatum), has a chaotic acoustic structure rather than the harmonic structure characteristic of most birdsongs. These findings support those of Fee et al. [Nature (London) 395(3), 67-71 (1999)] on nonlinear period-doubling transitions in the song of the zebra finch (Taeniopygia guttata). It is suggested that syllables with chaotic structure may be a feature of the songs of many birds. PMID:10955649

  16. Universal impedance fluctuations in wave chaotic systems.

    PubMed

    Hemmady, Sameer; Zheng, Xing; Ott, Edward; Antonsen, Thomas M; Anlage, Steven M

    2005-01-14

    We experimentally investigate theoretical predictions of universal impedance fluctuations in wave chaotic systems using a microwave analog of a quantum chaotic infinite square well potential. We emphasize the use of the radiation impedance to remove the nonuniversal effects of the particular coupling between the outside world and the scatterer. Specific predictions that we test include the probability density functions (PDFs) of the real and imaginary parts of the universal impedance, the equality of the variances of these PDFs, and the dependence of these PDFs on a single loss parameter.

  17. Chaotic correlations in barrier billiards with arbitrary barriers

    NASA Astrophysics Data System (ADS)

    Osbaldestin, A. H.; Adamson, L. N. C.

    2013-06-01

    We study autocorrelation functions in symmetric barrier billiards for golden mean trajectories with arbitrary barriers. Renormalization analysis reveals the presence of a chaotic invariant set and thus that, for a typical barrier, there are chaotic correlations. The chaotic renormalization set is the analogue of the so-called orchid that arises in a generalized Harper equation.

  18. Ex Situ Integration of Multifunctional Porous Polymer Monoliths into Thermoplastic Microfluidic Chips

    PubMed Central

    Kendall, Eric L.; Wienhold, Erik; Rahmanian, Omid D.; DeVoe, Don L.

    2014-01-01

    A unique method for incorporating functional porous polymer monolith elements into thermoplastic microfluidic chips is described. Monolith elements are formed in a microfabricated mold, rather than within the microchannels, and chemically functionalized off chip before insertion into solvent-softened thermoplastic microchannels during chip assembly. Because monoliths may be trimmed prior to final placement, control of their size, shape, and uniformity is greatly improved over in-situ photopolymerization methods. A characteristic trapezoidal profile facilitates rapid insertion and enables complete mechanical anchoring of the monolith periphery, eliminating the need for chemical attachment to the microchannel walls. Off-chip processing allows the parallel preparation of monoliths of differing compositions and surface chemistries in large batches. Multifunctional flow-through arrays of multiple monolith elements are demonstrated using this approach through the creation of a fluorescent immunosensor with integrated controls, and a microfluidic bubble separator comprising a combination of integrated hydrophobic and hydrophilic monolith elements. PMID:25018587

  19. A microfluidic two-pump system inspired by liquid feeding in mosquitoes

    NASA Astrophysics Data System (ADS)

    Marino, Andrew; Goad, Angela; Stremler, Mark; Socha, John; Jung, Sunghwan

    Mosquitoes feed on nectar and blood using a two-pump system in the head-a smaller cibarial pump in line with a larger a pharyngeal pump, with a valve in between. To suck, mosquitoes transport the liquid (which may be a multi-component viscous fluid, blood) through a long micro-channel, the proboscis. In the engineering realm, microfluidic devices in biomedical applications, such as lab-on-a-chip technology, necessitate implementing a robust pump design to handle clogging and increase flow control compared to a single-pump system. In this talk, we introduce a microfluidic pump design inspired by the mosquito's two-pump system. The pumping performance (flow rate) in presence of impurities (air bubbles, soft clogs) is quantified as a function of phase difference and volume expansion of the pumps, and the elasticity of the valve.

  20. 3D pulsed laser-triggered high-speed microfluidic fluorescence-activated cell sorter.

    PubMed

    Chen, Yue; Wu, Ting-Hsiang; Kung, Yu-Chun; Teitell, Michael A; Chiou, Pei-Yu

    2013-11-12

    We report a 3D microfluidic pulsed laser-triggered fluorescence-activated cell sorter capable of sorting at a throughput of 23 000 cells per s with 90% purity in high-purity mode and at a throughput of 45 000 cells per s with 45% purity in enrichment mode in one stage and in a single channel. This performance is realized by exciting laser-induced cavitation bubbles in a 3D PDMS microfluidic channel to generate high-speed liquid jets that deflect detected fluorescent cells and particles focused by 3D sheath flows. The ultrafast switching mechanism (20 μs complete on-off cycle), small liquid jet perturbation volume, and three-dimensional sheath flow focusing for accurate timing control of fast (1.5 m s(-1)) passing cells and particles are three critical factors enabling high-purity sorting at high-throughput in this sorter. PMID:23844418

  1. Mechanisms of single bubble cleaning.

    PubMed

    Reuter, Fabian; Mettin, Robert

    2016-03-01

    The dynamics of collapsing bubbles close to a flat solid is investigated with respect to its potential for removal of surface attached particles. Individual bubbles are created by nanosecond Nd:YAG laser pulses focused into water close to glass plates contaminated with melamine resin micro-particles. The bubble dynamics is analysed by means of synchronous high-speed recordings. Due to the close solid boundary, the bubble collapses with the well-known liquid jet phenomenon. Subsequent microscopic inspection of the substrates reveals circular areas clean of particles after a single bubble generation and collapse event. The detailed bubble dynamics, as well as the cleaned area size, is characterised by the non-dimensional bubble stand-off γ=d/Rmax, with d: laser focus distance to the solid boundary, and Rmax: maximum bubble radius before collapse. We observe a maximum of clean area at γ≈0.7, a roughly linear decay of the cleaned circle radius for increasing γ, and no cleaning for γ>3.5. As the main mechanism for particle removal, rapid flows at the boundary are identified. Three different cleaning regimes are discussed in relation to γ: (I) For large stand-off, 1.8<γ<3.5, bubble collapse induced vortex flows touch down onto the substrate and remove particles without significant contact of the gas phase. (II) For small distances, γ<1.1, the bubble is in direct contact with the solid. Fast liquid flows at the substrate are driven by the jet impact with its subsequent radial spreading, and by the liquid following the motion of the collapsing and rebounding bubble wall. Both flows remove particles. Their relative timing, which depends sensitively on the exact γ, appears to determine the extension of the area with forces large enough to cause particle detachment. (III) At intermediate stand-off, 1.1<γ<1.8, only the second bubble collapse touches the substrate, but acts with cleaning mechanisms similar to an effective small γ collapse: particles are removed by

  2. Mechanisms of single bubble cleaning.

    PubMed

    Reuter, Fabian; Mettin, Robert

    2016-03-01

    The dynamics of collapsing bubbles close to a flat solid is investigated with respect to its potential for removal of surface attached particles. Individual bubbles are created by nanosecond Nd:YAG laser pulses focused into water close to glass plates contaminated with melamine resin micro-particles. The bubble dynamics is analysed by means of synchronous high-speed recordings. Due to the close solid boundary, the bubble collapses with the well-known liquid jet phenomenon. Subsequent microscopic inspection of the substrates reveals circular areas clean of particles after a single bubble generation and collapse event. The detailed bubble dynamics, as well as the cleaned area size, is characterised by the non-dimensional bubble stand-off γ=d/Rmax, with d: laser focus distance to the solid boundary, and Rmax: maximum bubble radius before collapse. We observe a maximum of clean area at γ≈0.7, a roughly linear decay of the cleaned circle radius for increasing γ, and no cleaning for γ>3.5. As the main mechanism for particle removal, rapid flows at the boundary are identified. Three different cleaning regimes are discussed in relation to γ: (I) For large stand-off, 1.8<γ<3.5, bubble collapse induced vortex flows touch down onto the substrate and remove particles without significant contact of the gas phase. (II) For small distances, γ<1.1, the bubble is in direct contact with the solid. Fast liquid flows at the substrate are driven by the jet impact with its subsequent radial spreading, and by the liquid following the motion of the collapsing and rebounding bubble wall. Both flows remove particles. Their relative timing, which depends sensitively on the exact γ, appears to determine the extension of the area with forces large enough to cause particle detachment. (III) At intermediate stand-off, 1.1<γ<1.8, only the second bubble collapse touches the substrate, but acts with cleaning mechanisms similar to an effective small γ collapse: particles are removed by

  3. Integrated microfluidic probe station

    NASA Astrophysics Data System (ADS)

    Perrault, C. M.; Qasaimeh, M. A.; Brastaviceanu, T.; Anderson, K.; Kabakibo, Y.; Juncker, D.

    2010-11-01

    The microfluidic probe (MFP) consists of a flat, blunt tip with two apertures for the injection and reaspiration of a microjet into a solution—thus hydrodynamically confining the microjet—and is operated atop an inverted microscope that enables live imaging. By scanning across a surface, the microjet can be used for surface processing with the capability of both depositing and removing material; as it operates under immersed conditions, sensitive biological materials and living cells can be processed. During scanning, the MFP is kept immobile and centered over the objective of the inverted microscope, a few micrometers above a substrate that is displaced by moving the microscope stage and that is flushed continuously with the microjet. For consistent and reproducible surface processing, the gap between the MFP and the substrate, the MFP's alignment, the scanning speed, the injection and aspiration flow rates, and the image capture need all to be controlled and synchronized. Here, we present an automated MFP station that integrates all of these functionalities and automates the key operational parameters. A custom software program is used to control an independent motorized Z stage for adjusting the gap, a motorized microscope stage for scanning the substrate, up to 16 syringe pumps for injecting and aspirating fluids, and an inverted fluorescence microscope equipped with a charge-coupled device camera. The parallelism between the MFP and the substrate is adjusted using manual goniometer at the beginning of the experiment. The alignment of the injection and aspiration apertures along the scanning axis is performed using a newly designed MFP screw holder. We illustrate the integrated MFP station by the programmed, automated patterning of fluorescently labeled biotin on a streptavidin-coated surface.

  4. Acoustofluidics 16: acoustics streaming near liquid-gas interfaces: drops and bubbles.

    PubMed

    Sadhal, S S

    2012-08-21

    In this sixteenth part of the series on "Acoustofluidics-exploiting ultrasonic standing waves forces and acoustic streaming in microfluidic systems for cell and particle manipulation," we continue our discussion on the analytical aspects of the streaming phenomenon. In particular, the use of the singular perturbation technique for this class of problems is delineated with a set of examples where fluid-fluid interaction takes place. In this category, we focus on drops and bubbles, and deal specifically with the effect of interfacial mobility on the streaming flow. PMID:22776990

  5. Simulation of chaotic electrokinetic transport: performance of commercial software versus custom-built direct numerical simulation codes.

    PubMed

    Karatay, Elif; Druzgalski, Clara L; Mani, Ali

    2015-05-15

    Many microfluidic and electrochemical applications involve chaotic transport phenomena that arise due to instabilities stemming from coupling of hydrodynamics with ion transport and electrostatic forces. Recent investigations have revealed the contribution of a wide range of spatio-temporal scales in such electro-chaotic systems similar to those observed in turbulent flows. Given that these scales can span several orders of magnitude, significant numerical resolution is needed for accurate prediction of these phenomena. The objective of this work is to assess accuracy and efficiency of commercial software for prediction of such phenomena. We have considered the electroconvective flow induced by concentration polarization near an ion selective surface as a model problem representing chaotic elecrokinetic phenomena. We present detailed comparison of the performance of a general-purpose commercial computational fluid dynamics (CFD) and transport solver against a custom-built direct numerical simulation code that has been tailored to the specific physics of unsteady electrokinetic flows. We present detailed statistics including velocity and ion concentration spectra over a wide range of frequencies as well as time-averaged statistics and computational time required for each simulation. Our results indicate that while accuracy can be guaranteed with proper mesh resolution and avoiding numerical dissipation, commercial solvers are generally at least an order of magnitude slower than custom-built direct numerical simulation codes.

  6. Chaotic motif sampler: detecting motifs from biological sequences by using chaotic neurodynamics

    NASA Astrophysics Data System (ADS)

    Matsuura, Takafumi; Ikeguchi, Tohru

    Identification of a region in biological sequences, motif extraction problem (MEP) is solved in bioinformatics. However, the MEP is an NP-hard problem. Therefore, it is almost impossible to obtain an optimal solution within a reasonable time frame. To find near optimal solutions for NP-hard combinatorial optimization problems such as traveling salesman problems, quadratic assignment problems, and vehicle routing problems, chaotic search, which is one of the deterministic approaches, has been proposed and exhibits better performance than stochastic approaches. In this paper, we propose a new alignment method that employs chaotic dynamics to solve the MEPs. It is called the Chaotic Motif Sampler. We show that the performance of the Chaotic Motif Sampler is considerably better than that of the conventional methods such as the Gibbs Site Sampler and the Neighborhood Optimization for Multiple Alignment Discovery.

  7. Fabrication of plastic microfluidic components

    NASA Astrophysics Data System (ADS)

    Martin, Peter M.; Matson, Dean W.; Bennett, Wendy D.; Hammerstrom, D. J.

    1998-09-01

    Plastic components have many advantages, including ease of fabrication, low cost, chemical inertness, lightweight, and disposability. We report on the fabrication of three plastics-based microfluidic components: a motherboard, a dialysis unit, and a metal sensor. Microchannels, headers, and interconnects were produced in thin sheets (>=50 microns) of polyimide, PMMA, polyethylene, and polycarbonate using a direct-write excimer laser micromachining system. Machined sheets were laminated by thermal and adhesive bonding to form leak-tight microfluidic components. The microfluidic motherboard borrowed the `functionality on a chip' concept from the electronics industry and was the heart of a complex microfluidic analytical device. The motherboard platform was designed to be tightly integrated and self-contained (i.e., liquid flows are all confined within machined microchannels), reducing the need for tubing with fluid distribution and connectivity. This concept greatly facilitated system integration and miniaturization. As fabricated, the motherboard consisted of three fluid reservoirs connected to micropumps by microchannels. The fluids could either be pumped independently or mixed in microchannels prior to being directed to exterior analytical components via outlet ports. The microdialysis device was intended to separate electrolytic solutes from low volume samples prior to mass spectrometric analysis. The device consisted of a dialysis membrane laminated between opposed serpentine microchannels containing the sample fluid and a buffer solution. The laminated metal sensor consisted of fluid reservoirs, micro-flow channels, micropumps, mixing channels, reaction channels, and detector circuitry.

  8. Microfluidic-integrated DNA nanobiosensors.

    PubMed

    Ansari, M I Haque; Hassan, Shabir; Qurashi, Ahsanulhaq; Khanday, Firdous Ahmad

    2016-11-15

    Over the last few decades, an increased demand has emerged for integrating biosensors with microfluidic- and nanofluidic-based lab-on-chip (LOC) devices for point-of-care (POC) diagnostics, in the medical industry and environmental monitoring of pathogenic threat agents. Such a merger of microfluidics with biosensing technologies allows for the precise control of volumes, as low as one nanolitre and the integration of various types of bioassays on a single miniaturized platform. This integration offers several favorable advantages, such as low reagent consumption, automation of sample preparation, reduction in processing time, low cost analysis, minimal handling of hazardous materials, high detection accuracy, portability and disposability. This review provides a synopsis of the most recent developments in the microfluidic-integrated biosensing field by delineating the fundamental theory of microfluidics, fabrication techniques and a detailed account of the various transduction methods that are employed. Lastly, the review discusses state-of-the-art DNA biosensors with a focus on optical DNA biosensors.

  9. Bioinspired multicompartmental microfibers from microfluidics.

    PubMed

    Cheng, Yao; Zheng, Fuyin; Lu, Jie; Shang, Luoran; Xie, Zhuoying; Zhao, Yuanjin; Chen, Yongping; Gu, Zhongze

    2014-08-13

    Bioinspired multicompartmental microfibers are generated by novel capillary microfluidics. The resultant microfibers possess multicompartment body-and-shell compositions with specifically designed geometries. Potential use of these microfibers for tissue-engineering applications is demonstrated by creating multifunctional fibers with a spatially controlled encapsulation of cells.

  10. Microfluidic-integrated DNA nanobiosensors.

    PubMed

    Ansari, M I Haque; Hassan, Shabir; Qurashi, Ahsanulhaq; Khanday, Firdous Ahmad

    2016-11-15

    Over the last few decades, an increased demand has emerged for integrating biosensors with microfluidic- and nanofluidic-based lab-on-chip (LOC) devices for point-of-care (POC) diagnostics, in the medical industry and environmental monitoring of pathogenic threat agents. Such a merger of microfluidics with biosensing technologies allows for the precise control of volumes, as low as one nanolitre and the integration of various types of bioassays on a single miniaturized platform. This integration offers several favorable advantages, such as low reagent consumption, automation of sample preparation, reduction in processing time, low cost analysis, minimal handling of hazardous materials, high detection accuracy, portability and disposability. This review provides a synopsis of the most recent developments in the microfluidic-integrated biosensing field by delineating the fundamental theory of microfluidics, fabrication techniques and a detailed account of the various transduction methods that are employed. Lastly, the review discusses state-of-the-art DNA biosensors with a focus on optical DNA biosensors. PMID:27179566

  11. Initial conditions for bubble universes

    NASA Astrophysics Data System (ADS)

    McInnes, Brett

    2008-06-01

    The “bubble universes” of Coleman and De Luccia play a crucial role in string cosmology. Since our own Universe is supposed to be of this kind, bubble cosmology should supply definite answers to the long-standing questions regarding cosmological initial conditions. In particular, it must explain how an initial singularity is avoided, and also how the initial conditions for inflation were established. I argue that the simplest nonanthropic approach to these problems involves a requirement that the spatial sections defined by distinguished bubble observers should not be allowed to have arbitrarily small volumes. Casimir energy is a popular candidate for a quantum effect which can ensure this, but (because it violates energy conditions) there is a danger that it could lead to nonperturbative instabilities in string theory. I make a simple proposal for the initial conditions of a bubble universe, and show that my proposal ensures that the system is nonperturbatively stable. Thus, low-entropy conditions can be established at the beginning of a bubble universe without violating the second law of thermodynamics and without leading to instability in string theory. These conditions are inherited from the ambient spacetime.

  12. Ethnic diversity deflates price bubbles

    PubMed Central

    Levine, Sheen S.; Apfelbaum, Evan P.; Bernard, Mark; Bartelt, Valerie L.; Zajac, Edward J.; Stark, David

    2014-01-01

    Markets are central to modern society, so their failures can be devastating. Here, we examine a prominent failure: price bubbles. Bubbles emerge when traders err collectively in pricing, causing misfit between market prices and the true values of assets. The causes of such collective errors remain elusive. We propose that bubbles are affected by ethnic homogeneity in the market and can be thwarted by diversity. In homogenous markets, traders place undue confidence in the decisions of others. Less likely to scrutinize others’ decisions, traders are more likely to accept prices that deviate from true values. To test this, we constructed experimental markets in Southeast Asia and North America, where participants traded stocks to earn money. We randomly assigned participants to ethnically homogeneous or diverse markets. We find a marked difference: Across markets and locations, market prices fit true values 58% better in diverse markets. The effect is similar across sites, despite sizeable differences in culture and ethnic composition. Specifically, in homogenous markets, overpricing is higher as traders are more likely to accept speculative prices. Their pricing errors are more correlated than in diverse markets. In addition, when bubbles burst, homogenous markets crash more severely. The findings suggest that price bubbles arise not only from individual errors or financial conditions, but also from the social context of decision making. The evidence may inform public discussion on ethnic diversity: it may be beneficial not only for providing variety in perspectives and skills, but also because diversity facilitates friction that enhances deliberation and upends conformity. PMID:25404313

  13. Ethnic diversity deflates price bubbles.

    PubMed

    Levine, Sheen S; Apfelbaum, Evan P; Bernard, Mark; Bartelt, Valerie L; Zajac, Edward J; Stark, David

    2014-12-30

    Markets are central to modern society, so their failures can be devastating. Here, we examine a prominent failure: price bubbles. Bubbles emerge when traders err collectively in pricing, causing misfit between market prices and the true values of assets. The causes of such collective errors remain elusive. We propose that bubbles are affected by ethnic homogeneity in the market and can be thwarted by diversity. In homogenous markets, traders place undue confidence in the decisions of others. Less likely to scrutinize others' decisions, traders are more likely to accept prices that deviate from true values. To test this, we constructed experimental markets in Southeast Asia and North America, where participants traded stocks to earn money. We randomly assigned participants to ethnically homogeneous or diverse markets. We find a marked difference: Across markets and locations, market prices fit true values 58% better in diverse markets. The effect is similar across sites, despite sizeable differences in culture and ethnic composition. Specifically, in homogenous markets, overpricing is higher as traders are more likely to accept speculative prices. Their pricing errors are more correlated than in diverse markets. In addition, when bubbles burst, homogenous markets crash more severely. The findings suggest that price bubbles arise not only from individual errors or financial conditions, but also from the social context of decision making. The evidence may inform public discussion on ethnic diversity: it may be beneficial not only for providing variety in perspectives and skills, but also because diversity facilitates friction that enhances deliberation and upends conformity.

  14. Capillarity-Driven Bubble Separations

    NASA Astrophysics Data System (ADS)

    Wollman, Andrew; Weislogel, Mark; Dreyer, Michael

    2013-11-01

    Techniques for phase separation in the absence of gravity continue to be sought after 5 decades of space flight. This work focuses on the fundamental problem of gas bubble separation in bubbly flows through open wedge-shaped channel in a microgravity environment. The bubbles appear to rise in the channel and coalesce with the free surface. Forces acting on the bubble are the combined effects of surface tension, wetting conditions, and geometry; not buoyancy. A single dimensionless group is identified that characterizes the bubble behavior and supportive experiments are conducted in a terrestrial laboratory, in a 2.1 second drop tower, and aboard the International Space Station as part of the Capillary Channel Flow (CCF) experiments. The data is organized into regime maps that provide insight on passive phase separations for applications ranging from liquid management aboard spacecraft to lab-on-chip technologies. NASA NNX09AP66A, NASA Oregon Space Grant NNX10AK68H, NASA NNX12AO47A, DLR 50WM0535/0845/1145

  15. Shock formation within sonoluminescence bubbles

    SciTech Connect

    Vuong, V.Q.; Szeri, A.J.; Young, D.A.

    1999-01-01

    A strong case has been made by several authors that sharp, spherically symmetric shocks converging on the center of a spherical bubble driven by a strong acoustic field give rise to rapid compression and heating that produces the brief flash of light known as sonoluminescence. The formation of such shocks is considered. It is found that, although at the main collapse the bubble wall does indeed launch an inwardly-traveling compression wave, and although the subsequent reflection of the wave at the bubble center produces a very rapid temperature peak, the wave is prevented from steepening into a sharp shock by an adverse gradient in the sound speed caused by heat transfer. It is shown that the mathematical characteristics of the flow can be prevented from accumulating into a shock front by this adverse sound speed gradient. A range of results is presented for a variety of bubble ambient radii and sound field amplitudes suggested by experiments. The time scale of the peak temperature in the bubble is set by the dynamics of the compression wave: this is typically in the range 100{endash}300 ps (FWHM) in concert with recent measurements of the sonoluminescence pulse width. {copyright} {ital 1999 American Institute of Physics.}

  16. Multiplexing of discrete chaotic signals in presence of noise

    NASA Astrophysics Data System (ADS)

    Nagaraj, Nithin; Vaidya, Prabhakar G.

    2009-09-01

    Multiplexing of discrete chaotic signals in presence of noise is investigated. The existing methods are based on chaotic synchronization, which is susceptible to noise, precision limitations, and requires more iterates. Furthermore, most of these methods fail for multiplexing more than two discrete chaotic signals. We propose novel methods to multiplex multiple discrete chaotic signals based on the principle of symbolic sequence invariance in presence of noise and finite precision implementation of finding the initial condition of an arbitrarily long symbolic sequence of a chaotic map. Our methods work for single precision and as less as 35 iterates. For two signals, our method is robust up to 50% noise level.

  17. Light scattering by bubbles in a bubble chamber.

    PubMed

    Withrington, R J

    1968-01-01

    A discussion of the angular scattering expected from small bubbles in liquids of refractive indices 1.1 and 1.025 is given ogether with the inverse, i.e., of small spheres of the liquids in air. The similarities between the two scattering functions are compared with a view to the simulation of bubble chamber tracks using readily available materials. Fraunhofer scattering is significant on axis while larger angle scattering is geometrical. Some experimental verification of the scattering functions is also reported.

  18. Scaling regimes of thermocapillarity-driven dynamics of confined long bubbles: Effects of disjoining pressure

    NASA Astrophysics Data System (ADS)

    Chaudhury, Kaustav; Chakraborty, Suman

    2015-03-01

    During thermocapillary transport of a confined long bubble, we unveil the existence of a contrary-to-the-conventional disjoining-pressure-dominant scaling regime characterizing the dynamics of the thin liquid film engulfed between the bubble interface and the channel surface. Such a regime is realized for the limitingly small magnitude of the Marangoni stress (surface tension gradient) when the separating liquid region reaches an ultrathin dimension. Over this regime, we witness a severe breakdown of the seemingly intuitive scaling arguments based on the balance of viscous and capillary forces. Starting from competent balance criteria, we uncover the characteristic length scales involved, leading towards obtaining the new consistent scaling laws of the disjoining-pressure-dominant regime, in a simple closed form analytical fashion. Our scaling estimations are substantiated by full-scale numerical simulations of the pertinent thin-film equations. These new scaling laws appear to be convenient for implementing as a fundamental design basis for multiphase microfluidic systems.

  19. An Acoustofluidic Micromixer via Bubble Inception and Cavitation from Microchannel Sidewalls

    PubMed Central

    2015-01-01

    During the deep reactive ion etching process, the sidewalls of a silicon mold feature rough wavy structures, which can be transferred onto a polydimethylsiloxane (PDMS) microchannel through the soft lithography technique. In this article, we utilized the wavy structures of PDMS microchannel sidewalls to initiate and cavitate bubbles in the presence of acoustic waves. Through bubble cavitation, this acoustofluidic approach demonstrates fast, effective mixing in microfluidics. We characterized its performance by using viscous fluids such as poly(ethylene glycol) (PEG). When two PEG solutions with a resultant viscosity 54.9 times higher than that of water were used, the mixing efficiency was found to be 0.92, indicating excellent, homogeneous mixing. The acoustofluidic micromixer presented here has the advantages of simple fabrication, easy integration, and capability to mix high-viscosity fluids (Reynolds number: ∼0.01) in less than 100 ms. PMID:24754496

  20. Chaotic particle motion under linear surface waves.

    PubMed

    Bohr, Tomas; Hansen, Jonas Lundbek

    1996-12-01

    We investigate the motion of infinitesimal particles in the flow field inside the fluid under a traveling surface wave. It is shown that, even for two-dimensional waves, a superposition of two or more traveling harmonic waves is enough to generate chaotic particle motion, i.e., Lagrangian chaos. (c) 1996 American Institute of Physics.

  1. Musical variations from a chaotic mapping.

    PubMed

    Dabby, Diana S.

    1996-06-01

    A chaotic mapping provides a technique for generating musical variations of an original work. This technique, based on the sensitivity of chaotic trajectories to initial conditions, produces changes in the pitch sequence of a piece. A sequence of musical pitches {p(i)}, i.e., any piece ranging from Bach (or earlier) to contemporary music, is paired with the x-components {x(i)} of a Lorenz chaotic trajectory. Each p(i) is marked on the x axis at the point designated by its x(i). In this way, the x axis becomes a pitch axis configured according to the notes of the original composition. Then, a second chaotic trajectory, whose initial condition differs from the first, is launched. Its x-components trigger pitches on the pitch axis (via the mapping) that vary in sequence from the original work, thus creating a variation. There are virtually an unlimited number of variations possible, many appealing to expert and nonexpert alike. (c) 1996 American Institute of Physics.

  2. Integrated method for chaotic time series analysis

    DOEpatents

    Hively, L.M.; Ng, E.G.

    1998-09-29

    Methods and apparatus for automatically detecting differences between similar but different states in a nonlinear process monitor nonlinear data are disclosed. Steps include: acquiring the data; digitizing the data; obtaining nonlinear measures of the data via chaotic time series analysis; obtaining time serial trends in the nonlinear measures; and determining by comparison whether differences between similar but different states are indicated. 8 figs.

  3. Integrated method for chaotic time series analysis

    DOEpatents

    Hively, Lee M.; Ng, Esmond G.

    1998-01-01

    Methods and apparatus for automatically detecting differences between similar but different states in a nonlinear process monitor nonlinear data. Steps include: acquiring the data; digitizing the data; obtaining nonlinear measures of the data via chaotic time series analysis; obtaining time serial trends in the nonlinear measures; and determining by comparison whether differences between similar but different states are indicated.

  4. Heat and chaotic velocity in special relativity

    SciTech Connect

    Garcia-Perciante, A. L.

    2011-03-24

    The nature of the heat flux in special relativistic kinetic theory is discussed to some detail emphasizing the need to explicitly include the chaotic velocity in order to correctly define dissipative fluxes while retaining both their physical meaning and the Lorentz covariance of the theory.

  5. Scattering Properties of Chaotic Microwave Resonators

    NASA Astrophysics Data System (ADS)

    Stöckmann, Hans-Jürgen

    2008-11-01

    The state of the art of microwave studies of chaotic and disordered microwave billiards is presented, with special emphasis on possible applications to the emission patterns of microdisk lasers, transport through quantum dots, and the stability of quantum systems against perturbations

  6. Gravity driven flows of bubble suspensions.

    NASA Astrophysics Data System (ADS)

    Zenit, Roberto; Koch, Donald L.; Sangani, Ashok K.

    1999-11-01

    Experiments on vertical and inclined channels were performed to study the behavior of a mono-dispersed bubble suspension for which the dual limit of large Reynolds number and small Weber number is satisfied. A uniform stream of 1.5 mm diameter bubbles is produced by a bank of identical capillaries and coalescence is inhibited by addition of salt to the water. Measurements of the liquid velocity and bubble-probe collision rate are obtained with a hot wire anemometer. The gas volume fraction, bubble velocity, velocity variance and chord length are measured using a dual impedance probe. Image analysis is used to quantify the distributions of bubble size and aspect ratio. For vertical channels the bubble velocity is observed to decrease as the bubble concentration increases in accord with the predictions of Spelt and Sangani (1998). The bubble velocity variance arises largely due to bubble-wall and bubble-bubble collisions. For inclined channels, the strength of the shear flow is controlled by the extent of bubble segregation and the effective viscosity of the bubble phase. The measurements are compared with solutions of the averaged equations of motion for a range of gas volume fractions and channel inclination angles.

  7. Coalescence of bubbles translating through a tube.

    PubMed

    Almatroushi, Eisa; Borhan, Ali

    2006-09-01

    The results of an experimental study of the interaction and coalescence of two air bubbles translating in a cylindrical tube are presented. Both pressure- and buoyancy-driven motion of the two bubbles in a Newtonian suspending fluid within the tube are considered. The close approach of the two bubbles is examined using image analysis, and measurements of the coalescence time are reported for various bubble size ratios and capillary numbers. For pressure-driven motion of bubbles, coalescence is found to occur in an axisymmetric configuration for all bubble size ratios considered in the experiments. For buoyancy-driven motion, on the other hand, the disturbance flow behind the leading bubble causes the trailing bubble to move radially out toward the tube wall when the trailing bubble size becomes very small compared to the size of the leading bubble. In that case, coalescence occurs in a nonaxisymmetric configuration, with a time scale for coalescence that is substantially larger than that for coalescence in the axisymmetric configuration. When the imposed flow is in the direction of the buoyancy force, coalescence time is independent of bubble size ratio, and decreases as the capillary number increases. Experimental measurements of the radius of the thin liquid film separating the two bubbles are used in conjunction with a simple film drainage model to predict the dependence of the coalescence time on the bubble size ratio. PMID:17124143

  8. Aspherical bubble dynamics and oscillation times

    SciTech Connect

    Godwin, R.P.; Chapyak, E.J.; Noack, J.; Vogel, A.

    1999-03-01

    The cavitation bubbles common in laser medicine are rarely perfectly spherical and are often located near tissue boundaries, in vessels, etc., which introduce aspherical dynamics. Here, novel features of aspherical bubble dynamics are explored. Time-resolved experimental photographs and simulations of large aspect ratio (length:diameter {approximately}20) cylindrical bubble dynamics are presented. The experiments and calculations exhibit similar dynamics. A small high-pressure cylindrical bubble initially expands radially with hardly any axial motion. Then, after reaching its maximum volume, a cylindrical bubble collapses along its long axis with relatively little radial motion. The growth-collapse period of these very aspherical bubbles differs only sightly from twice the Rayleigh collapse time for a spherical bubble with an equivalent maximum volume. This fact justifies using the temporal interval between the acoustic signals emitted upon bubble creation and collapse to estimate the maximum bubble volume. As a result, hydrophone measurements can provide an estimate of the bubble energy even for aspherical bubbles. The prolongation of the oscillation period of bubbles near solid boundaries relative to that of isolated spherical bubbles is also discussed.

  9. Self-Powered Triboelectric Micro Liquid/Gas Flow Sensor for Microfluidics.

    PubMed

    Chen, Jie; Guo, Hengyu; Zheng, Jiangeng; Huang, Yingzhou; Liu, Guanlin; Hu, Chenguo; Wang, Zhong Lin

    2016-08-23

    Liquid and gas flow sensors are important components of the micro total analysis systems (μTAS) for modern analytical sciences. In this paper, we proposed a self-powered triboelectric microfluidic sensor (TMS) by utilizing the signals produced from the droplet/bubble via the capillary and the triboelectrification effects on the liquid/solid interface for real-time liquid and gas flow detection. By alternating capillary with different diameters, the sensor's detecting range and sensitivity can be adjusted. Both the relationship between the droplet/bubble and capillary size, and the output signal of the sensor are systematically studied. By demonstrating the monitoring of the transfusion process for a patient and the gas flow produced from an injector, it shows that TMS has a great potential in building a self-powered micro total analysis system.

  10. Self-Powered Triboelectric Micro Liquid/Gas Flow Sensor for Microfluidics.

    PubMed

    Chen, Jie; Guo, Hengyu; Zheng, Jiangeng; Huang, Yingzhou; Liu, Guanlin; Hu, Chenguo; Wang, Zhong Lin

    2016-08-23

    Liquid and gas flow sensors are important components of the micro total analysis systems (μTAS) for modern analytical sciences. In this paper, we proposed a self-powered triboelectric microfluidic sensor (TMS) by utilizing the signals produced from the droplet/bubble via the capillary and the triboelectrification effects on the liquid/solid interface for real-time liquid and gas flow detection. By alternating capillary with different diameters, the sensor's detecting range and sensitivity can be adjusted. Both the relationship between the droplet/bubble and capillary size, and the output signal of the sensor are systematically studied. By demonstrating the monitoring of the transfusion process for a patient and the gas flow produced from an injector, it shows that TMS has a great potential in building a self-powered micro total analysis system. PMID:27490518

  11. Chaotic Map Construction from Common Nonlinearities and Microcontroller Implementations

    NASA Astrophysics Data System (ADS)

    Ablay, Günyaz

    2016-06-01

    This work presents novel discrete-time chaotic systems with some known physical system nonlinearities. Dynamic behaviors of the models are examined with numerical methods and Arduino microcontroller-based experimental studies. Many new chaotic maps are generated in the form of x(k + 1) = rx(k) + f(x(k)) and high-dimensional chaotic systems are obtained by weak coupling or cross-coupling the same or different chaotic maps. An application of the chaotic maps is realized with Arduino for chaotic pulse width modulation to drive electrical machines. It is expected that the new chaotic maps and their microcontroller implementations will facilitate practical chaos-based applications in different fields.

  12. Bubbles Responding to Ultrasound Pressure

    NASA Technical Reports Server (NTRS)

    2003-01-01

    The Bubble and Drop Nonlinear Dynamics (BDND) experiment was designed to improve understanding of how the shape and behavior of bubbles respond to ultrasound pressure. By understanding this behavior, it may be possible to counteract complications bubbles cause during materials processing on the ground. This 12-second sequence came from video downlinked from STS-94, July 5 1997, MET:3/19:15 (approximate). The BDND guest investigator was Gary Leal of the University of California, Santa Barbara. The experiment was part of the space research investigations conducted during the Microgravity Science Laboratory-1R mission (STS-94, July 1-17 1997). Advanced fluid dynamics experiments will be a part of investigations plarned for the International Space Station. (435KB, 13-second MPEG, screen 160 x 120 pixels; downlinked video, higher quality not available) A still JPG composite of this movie is available at http://mix.msfc.nasa.gov/ABSTRACTS/MSFC-0300162.html.

  13. Topological analysis of chaotic orbits: Revisiting Hyperion

    NASA Technical Reports Server (NTRS)

    Boyd, Patricia T.; Mindlin, Gabriel B.; Gilmore, Robert; Solari, Hernan G.

    1994-01-01

    There is emerging interest in the possibility of chaotic evolution in astrophysical systems. To mention just one example, recent well-sampled ground-based observations of the Saturian satellite Hyperion strongly suggest that it is exhibiting chaotic behavior. We present a general technique, the method of close returns, for the analysis of data from astronomical objects believed to be exhibiting chaotic motion. The method is based on the extraction of pieces of the evolution that exhibit nearly periodic behavior-episodes during which the object stays near in phase space to some unstable periodic orbit. Such orbits generally act as skeletal features, tracing the topological organization of the manifold on which the chaotic dynamics takes place. This method does not require data sets as lengthy as other nonlinear analysis techniques do and is therefore well suited to many astronomical observing programs. Well sampled data covering between twenty and forty characteristic periods of the system have been found to be sufficient for the application of this technique. Additional strengths of this method are its robustness in the presence of noise and the ability for a user to clearly distinguish between periodic, random, and chaotic behavior by inspection of the resulting two-dimensional image. As an example of its power, we analyze close returns in a numerically generated data set, based on a model for Hyperion extensively studied in the literature, corresponding to nightly observations of the satellite. We show that with a small data set, embedded unstable periodic orbits can be extracted and that these orbits can be responsible for nearly periodic behavior lasting a substantial fraction of the observing run.

  14. Shadowing Lemma and Chaotic Orbit Determination

    NASA Astrophysics Data System (ADS)

    Milani Comparetti, Andrea; Spoto, Federica

    2015-08-01

    Orbit determination is possible for a chaotic orbit of a dynamical system, given a finite set of observations, provided the initial conditions are at the central time. We test both the convergence of the orbit determination procedure and the behavior of the uncertainties as a function of the maximum number n of map iterations observed; this by using a simple discrete model, namely the standard map. Two problems appear: first, the orbit determination is made impossible by numerical instability beyond a computability horizon, which can be approximately predicted by a simple formula containing the Lyapounov time and the relative roundoff error. Second, the uncertainty of the results is sharply increased if a dynamical parameter (contained in the standard map formula) is added to the initial conditions as parameter to be estimated. In particular the uncertainty of the dynamical parameter, and of at least one of the initial conditions, decreases like n^a with a<0 but not large (of the order of unity). If only the initial conditions are estimated, their uncertainty decreases exponentially with n, thus it becomes very small. All these phenomena occur when the chosen initial conditions belong to a chaotic orbit (as shown by one of the well known Lyapounov indicators). If they belong to a non-chaotic orbit the computational horizon is much larger, if it exists at all, and the decrease of the uncertainty appears to be polynomial in all parameters, like n^a with a approximately 1/2; the difference between the case with and without dynamical parameter estimated disappears. These phenomena, which we can investigate in a simple model, have significant implications in practical problems of orbit determination involving chatic phenomena, such as the chaotic rotation state of a celestial body and a chaotic orbit of a planet-crossing asteroid undergoing many close approaches.

  15. Shadowing Lemma and chaotic orbit determination

    NASA Astrophysics Data System (ADS)

    Spoto, Federica; Milani, Andrea

    2016-03-01

    Orbit determination is possible for a chaotic orbit of a dynamical system, given a finite set of observations, provided the initial conditions are at the central time. The Shadowing Lemma (Anosov 1967; Bowen in J Differ Equ 18:333-356, 1975) can be seen as a way to connect the orbit obtained using the observations with a real trajectory. An orbit is a shadowing of the trajectory if it stays close to the real trajectory for some amount of time. In a simple discrete model, the standard map, we tackle the problem of chaotic orbit determination when observations extend beyond the predictability horizon. If the orbit is hyperbolic, a shadowing orbit is computed by the least squares orbit determination. We test both the convergence of the orbit determination iterative procedure and the behaviour of the uncertainties as a function of the maximum number of map iterations observed. When the initial conditions belong to a chaotic orbit, the orbit determination is made impossible by numerical instability beyond a computability horizon, which can be approximately predicted by a simple formula. Moreover, the uncertainty of the results is sharply increased if a dynamical parameter is added to the initial conditions as parameter to be estimated. The Shadowing Lemma does not dictate what the asymptotic behaviour of the uncertainties should be. These phenomena have significant implications, which remain to be studied, in practical problems of orbit determination involving chaos, such as the chaotic rotation state of a celestial body and a chaotic orbit of a planet-crossing asteroid undergoing many close approaches.

  16. Bursting Bubbles and Bilayers

    PubMed Central

    Wrenn, Steven P.; Dicker, Stephen M.; Small, Eleanor F.; Dan, Nily R.; Mleczko, Michał; Schmitz, Georg; Lewin, Peter A.

    2012-01-01

    This paper discusses various interactions between ultrasound, phospholipid monolayer-coated gas bubbles, phospholipid bilayer vesicles, and cells. The paper begins with a review of microbubble physics models, developed to describe microbubble dynamic behavior in the presence of ultrasound, and follows this with a discussion of how such models can be used to predict inertial cavitation profiles. Predicted sensitivities of inertial cavitation to changes in the values of membrane properties, including surface tension, surface dilatational viscosity, and area expansion modulus, indicate that area expansion modulus exerts the greatest relative influence on inertial cavitation. Accordingly, the theoretical dependence of area expansion modulus on chemical composition - in particular, poly (ethylene glyclol) (PEG) - is reviewed, and predictions of inertial cavitation for different PEG molecular weights and compositions are compared with experiment. Noteworthy is the predicted dependence, or lack thereof, of inertial cavitation on PEG molecular weight and mole fraction. Specifically, inertial cavitation is predicted to be independent of PEG molecular weight and mole fraction in the so-called mushroom regime. In the “brush” regime, however, inertial cavitation is predicted to increase with PEG mole fraction but to decrease (to the inverse 3/5 power) with PEG molecular weight. While excellent agreement between experiment and theory can be achieved, it is shown that the calculated inertial cavitation profiles depend strongly on the criterion used to predict inertial cavitation. This is followed by a discussion of nesting microbubbles inside the aqueous core of microcapsules and how this significantly increases the inertial cavitation threshold. Nesting thus offers a means for avoiding unwanted inertial cavitation and cell death during imaging and other applications such as sonoporation. A review of putative sonoporation mechanisms is then presented, including those

  17. A surface acoustic wave (SAW)-enhanced grating-coupling phase-interrogation surface plasmon resonance (SPR) microfluidic biosensor.

    PubMed

    Sonato, A; Agostini, M; Ruffato, G; Gazzola, E; Liuni, D; Greco, G; Travagliati, M; Cecchini, M; Romanato, F

    2016-04-01

    A surface acoustic wave (SAW)-enhanced, surface plasmon resonance (SPR) microfluidic biosensor in which SAW-induced mixing and phase-interrogation grating-coupling SPR are combined in a single lithium niobate lab-on-a-chip is demonstrated. Thiol-polyethylene glycol adsorption and avidin/biotin binding kinetics were monitored by exploiting the high sensitivity of grating-coupling SPR under azimuthal control. A time saturation binding kinetics reduction of 82% and 24% for polyethylene and avidin adsorption was obtained, respectively, due to the fluid mixing enhancement by means of the SAW-generated chaotic advection. These results represent the first implementation of a nanostructured SAW-SPR microfluidic biochip capable of significantly improving the molecule binding kinetics on a single, portable device. In addition, the biochip here proposed is suitable for a great variety of biosensing applications.

  18. A surface acoustic wave (SAW)-enhanced grating-coupling phase-interrogation surface plasmon resonance (SPR) microfluidic biosensor.

    PubMed

    Sonato, A; Agostini, M; Ruffato, G; Gazzola, E; Liuni, D; Greco, G; Travagliati, M; Cecchini, M; Romanato, F

    2016-04-01

    A surface acoustic wave (SAW)-enhanced, surface plasmon resonance (SPR) microfluidic biosensor in which SAW-induced mixing and phase-interrogation grating-coupling SPR are combined in a single lithium niobate lab-on-a-chip is demonstrated. Thiol-polyethylene glycol adsorption and avidin/biotin binding kinetics were monitored by exploiting the high sensitivity of grating-coupling SPR under azimuthal control. A time saturation binding kinetics reduction of 82% and 24% for polyethylene and avidin adsorption was obtained, respectively, due to the fluid mixing enhancement by means of the SAW-generated chaotic advection. These results represent the first implementation of a nanostructured SAW-SPR microfluidic biochip capable of significantly improving the molecule binding kinetics on a single, portable device. In addition, the biochip here proposed is suitable for a great variety of biosensing applications. PMID:26932784

  19. Super Bubble and For Fingers Only.

    ERIC Educational Resources Information Center

    Barrow, Lloyd H.; And Others

    1997-01-01

    Presents two activities, the "Super Bubble" that challenges students and parents to blow the biggest bubbles and "For Fingers Only" that asks them to duplicate a pattern of blocks using only the sense of touch. (JRH)

  20. Removal of hydrogen bubbles from nuclear reactors

    NASA Technical Reports Server (NTRS)

    Jenkins, R. V.

    1980-01-01

    Method proposed for removing large hydrogen bubbles from nuclear environment uses, in its simplest form, hollow spheres of palladium or platinum. Methods would result in hydrogen bubble being reduced in size without letting more radioactivity outside reactor.

  1. Unorthodox bubbles when boiling in cold water.

    PubMed

    Parker, Scott; Granick, Steve

    2014-01-01

    High-speed movies are taken when bubbles grow at gold surfaces heated spotwise with a near-infrared laser beam heating water below the boiling point (60-70 °C) with heating powers spanning the range from very low to so high that water fails to rewet the surface after bubbles detach. Roughly half the bubbles are conventional: They grow symmetrically through evaporation until buoyancy lifts them away. Others have unorthodox shapes and appear to contribute disproportionately to heat transfer efficiency: mushroom cloud shapes, violently explosive bubbles, and cavitation events, probably stimulated by a combination of superheating, convection, turbulence, and surface dewetting during the initial bubble growth. Moreover, bubbles often follow one another in complex sequences, often beginning with an unorthodox bubble that stirs the water, followed by several conventional bubbles. This large dataset is analyzed and discussed with emphasis on how explosive phenomena such as cavitation induce discrepancies from classical expectations about boiling.

  2. Soap Bubbles on a Cold Day.

    ERIC Educational Resources Information Center

    Waiveris, Charles

    1994-01-01

    Discusses the effects of blowing bubbles in extremely cold weather. Describes the freezing conditions of the bubbles and some physical properties. Suggests using the activity with all ages of students. (MVL)

  3. Bubble memory module for spacecraft application

    NASA Technical Reports Server (NTRS)

    Hayes, P. J.; Looney, K. T.; Nichols, C. D.

    1985-01-01

    Bubble domain technology offers an all-solid-state alternative for data storage in onboard data systems. A versatile modular bubble memory concept was developed. The key module is the bubble memory module which contains all of the storage devices and circuitry for accessing these devices. This report documents the bubble memory module design and preliminary hardware designs aimed at memory module functional demonstration with available commercial bubble devices. The system architecture provides simultaneous operation of bubble devices to attain high data rates. Banks of bubble devices are accessed by a given bubble controller to minimize controller parts. A power strobing technique is discussed which could minimize the average system power dissipation. A fast initialization method using EEPROM (electrically erasable, programmable read-only memory) devices promotes fast access. Noise and crosstalk problems and implementations to minimize these are discussed. Flight memory systems which incorporate the concepts and techniques of this work could now be developed for applications.

  4. Falling Bubbles Demonstrate Acceleration of Gravity.

    ERIC Educational Resources Information Center

    Peterson, Wayne D.

    1980-01-01

    Describes a milk bubble machine to be used to demonstrate the acceleration of gravity in the classroom. Instructions are given for the construction of the milk-bubble-acceleration-of-gravity machine. (Author/DS)

  5. Behavior of Rapidly Sheared Bubble Suspensions

    NASA Technical Reports Server (NTRS)

    Sangani, A. S.; Kushch, V. I.; Hoffmann, M.; Nahra, H.; Koch, D. L.; Tsang, Y.

    2002-01-01

    An experiment to be carried out aboard the International Space Station is described. A suspension consisting of millimeter-sized bubbles in water containing some dissolved salt, which prevents bubbles from coalescing, will be sheared in a Couette cylindrical cell. Rotation of the outer cylinder will produce centrifugal force which will tend to accumulate the bubbles near the inner wall. The shearing will enhance collisions among bubbles creating thereby bubble phase pressure that will resist the tendency of the bubbles to accumulate near the inner wall. The bubble volume fraction and velocity profiles will be measured and compared with the theoretical predictions. Ground-based research on measurement of bubble phase properties and flow in vertical channel are described.

  6. Bubble-bubble interaction: A potential source of cavitation noise

    NASA Astrophysics Data System (ADS)

    Ida, Masato

    2009-01-01

    The interaction between microbubbles through pressure pulses has been studied to show that it can be a source of cavitation noise. A recent report demonstrated that the acoustic noise generated by a shrimp originates from the collapse of a cavitation bubble produced when the shrimp closes its snapper claw. The recorded acoustic signal contains a broadband noise that consists of positive and negative pulses, but a theoretical model for single bubbles fails to reproduce the negative ones. Using a nonlinear multibubble model, we have shown here that the negative pulses can be explained by considering the interaction of microbubbles formed after the cavitation bubble has collapsed and fragmented: Positive pulses produced at the collapse of the microbubbles hit and impulsively compress neighboring microbubbles to generate reflected pulses whose amplitudes are negative. Discussing the details of the noise generation process, we have found that no negative pulses are generated if the internal pressure of the reflecting bubble is very high when hit by a positive pulse.

  7. Period-adding route in sparkling bubbles.

    PubMed

    Liger-Belair, Gérard; Tufaile, Alberto; Robillard, Bertrand; Jeandet, Philippe; Sartorelli, José Carlos

    2005-09-01

    Chains of bubbles are seen rising along the wall whenever champagne is poured into a glass. The careful observation of a given bubble chain often reveals that the interbubble distance suddenly changes during the degassing process, indicating different bubbling regimes in this elusive phenomenon of effervescence. We report the transitions between these different bubbling regimes that present sequences of multiple periods known as the period-adding route.

  8. Magma mixing enhanced by bubble segregation

    NASA Astrophysics Data System (ADS)

    Wiesmaier, S.; Daniele, M.; Renggli, C.; Perugini, D.; De Campos, C.; Hess, K. U.; Ertel-Ingrisch, W.; Lavallée, Y.; Dingwell, D. B.

    2014-12-01

    Rising bubbles may significantly affect magma mixing paths as has been demonstrated by analogue experiments in the past. Here, bubble-advection experiments are performed for the first time employing natural materials at magmatic temperatures. Cylinders of basaltic glass were placed below cylinders of rhyolite glass. Upon melting, interstitial air formed bubbles that rose into the rhyolite melt, thereby entraining tails of basaltic liquid. The formation of plume-like filaments of advected basalt within the rhyolite was characterized by microCT and subsequent high-resolution EMP analyses. Melt entrainment by bubble ascent appears as efficient mechanism to mingle contrasting melt compositions. MicroCT imaging shows bubbles trailing each other and trails of multiple bubbles having converged. Rheological modelling of the filaments yields viscosities of up to 2 orders of magnitude lower than for the surrounding rhyolitic liquid. Such a viscosity contrast implies that subsequent bubbles rising are likely to follow the same pathways that previously ascending bubbles have generated. Filaments formed by multiple bubbles would thus experience episodic replenishment with mafic material. Fundamental implications for the concept of bubble advection in magma mixing are thus a) an acceleration of mixing because of decreased viscous resistance for bubbles inside filaments and b) non-conventional diffusion systematics because of intermittent supply of mafic material (instead of a single pulse) inside a filament. Inside these filaments, the mafic material was variably hybridised to andesitic through rhyolitic composition. Compositional profiles alone are ambiguous, however, to determine whether single or multiple bubbles were involved during formation of a filament. Statistical analysis, employing concentration variance as measure of homogenisation, demonstrates that also filaments appearing as single-bubble filaments are likely to have experienced multiple bubbles passing through

  9. Tunable power law in the desynchronization events of coupled chaotic electronic circuits

    SciTech Connect

    Oliveira, Gilson F. de Lorenzo, Orlando di; Chevrollier, Martine; Passerat de Silans, Thierry; Oriá, Marcos; Souza Cavalcante, Hugo L. D. de

    2014-03-15

    We study the statistics of the amplitude of the synchronization error in chaotic electronic circuits coupled through linear feedback. Depending on the coupling strength, our system exhibits three qualitatively different regimes of synchronization: weak coupling yields independent oscillations; moderate to strong coupling produces a regime of intermittent synchronization known as attractor bubbling; and stronger coupling produces complete synchronization. In the regime of moderate coupling, the probability distribution for the sizes of desynchronization events follows a power law, with an exponent that can be adjusted by changing the coupling strength. Such power-law distributions are interesting, as they appear in many complex systems. However, most of the systems with such a behavior have a fixed value for the exponent of the power law, while here we present an example of a system where the exponent of the power law is easily tuned in real time.

  10. PDMS-based turbulent microfluidic mixer.

    PubMed

    You, Jae Bem; Kang, Kyowon; Tran, Thanh Tinh; Park, Hongkeun; Hwang, Wook Ryol; Kim, Ju Min; Im, Sung Gap

    2015-04-01

    Over the past decade, homogeneous mixing in microfluidic devices has been a critical challenge, because of the inherently low flow rates in microfluidic channels. Although several mixer designs have been suggested to achieve efficient mixing, most of them involve intricate structures requiring a series of laborious fabrication processes. Operation at high flow rates can greatly enhance mixing by induction of turbulence, but devices that can resist such a high pressure drop to induce turbulence in microfluidic channels are difficult to fabricate, especially for commonly used poly(dimethylsiloxane) (PDMS)-based microfluidic devices. We have developed a Y-shaped, turbulent microfluidic mixer made of PDMS and a glass substrate by strong bonding of the substrates to a nanoadhesive layer deposited via initiated chemical vapor deposition. The high bonding strength of the nanoadhesive layer enables safe operation of the PDMS/glass turbulent microfluidic mixer at a total water flow rate of 40 mL min(-1), corresponding to a Reynolds number, Re, of ~4423, one of the highest values achieved in a microfluidic channel. The turbulence generated as a result of the high Re allows rapid mixing of the input fluids on contact. Image analysis showed that mixing started as soon as the fluids were introduced into the mixer. The experimental results matched the numerical predictions well, demonstrating that convective mixing was dominant as a result of turbulence induced in the microfluidic channel. Using the turbulent microfluidic mixer, we have demonstrated high throughput formation of emulsions with narrower size distribution. It was shown that as the flow rate increases inside the microfluidic channel, the size distribution of resulting emulsions decreases owing to the increase in the turbulent energy dissipation. The turbulent microfluidic mixer developed in this work not only enables rapid mixing of streams, but also increases throughputs of microfluidic reactors.

  11. Frictional drag reduction by bubble injection

    NASA Astrophysics Data System (ADS)

    Murai, Yuichi

    2014-07-01

    The injection of gas bubbles into a turbulent boundary layer of a liquid phase has multiple different impacts on the original flow structure. Frictional drag reduction is a phenomenon resulting from their combined effects. This explains why a number of different void-drag reduction relationships have been reported to date, while early works pursued a simple universal mechanism. In the last 15 years, a series of precisely designed experimentations has led to the conclusion that the frictional drag reduction by bubble injection has multiple manifestations dependent on bubble size and flow speed. The phenomena are classified into several regimes of two-phase interaction mechanisms. Each regime has inherent physics of bubbly liquid, highlighted by keywords such as bubbly mixture rheology, the spectral response of bubbles in turbulence, buoyancy-dominated bubble behavior, and gas cavity breakup. Among the regimes, bubbles in some selected situations lose the drag reduction effect owing to extra momentum transfer promoted by their active motions. This separates engineers into two communities: those studying small bubbles for high-speed flow applications and those studying large bubbles for low-speed flow applications. This article reviews the roles of bubbles in drag reduction, which have been revealed from fundamental studies of simplified flow geometries and from development of measurement techniques that resolve the inner layer structure of bubble-mixed turbulent boundary layers.

  12. Sheathless particle focusing in a microfluidic chamber by using the thermoplasmonic Marangoni effect

    NASA Astrophysics Data System (ADS)

    Namura, Kyoko; Nakajima, Kaoru; Kimura, Kenji; Suzuki, Motofumi

    2016-02-01

    We experimentally investigated the modes of the Marangoni flow around a microbubble in a 50-μm-thick water chamber and found a transition flow mode that enables sheathless particle focusing. A temperature gradient was thermoplasmonically induced around the laser spot on a gold nanoisland film, and Marangoni flows were generated around the microbubble to drive submicron particles dispersed in the water. When the laser spot was slightly displaced from the bubble center, the particles were continuously collected by the bubble underneath and leaked in one direction to form a focused particle stream. The generation of the particle-focusing Marangoni flow was attributed to the appropriate balance of the temperature gradient in the perpendicular and horizontal directions of the chamber, which was controlled by the laser spot position against the bubble center. Temporally controlling this flow mode with laser power caused the periodic emission of clustered particles from the bubble underneath. This particle handling method with a thermoplasmonic Marangoni flow can be useful for improving the efficiency of reaction or sensing processes that take place in a microfluidic chamber.

  13. Complex micropatterning of proteins within microfluidic channels.

    PubMed

    Kim, Miju; Doh, Junsang

    2014-01-01

    Microfluidic channels containing protein micropatterned surfaces are useful in many bioanalytical and biological applications. In this study, we developed a new method to integrate microfluidics and protein micropatterning by attaching poly(dimethylsiloxane) (PDMS) microfluidic channels to bio-friendly photoresist films via poly(dopamine) (PDA) adhesive. A bio-friendly photoresist poly(2,2-dimethoxy nitrobenzyl methacrylate-r-methyl methacrylate-r-poly(ethylene glycol) methacrylate) (PDMP) was synthesized and used. By performing microscope projection photolithography (MPP) to the PDMP thin films within PDMS microchannels, complex micropatterns of proteins were successfully generated within microfluidic channels. PMID:25570075

  14. LRL 25-inch Bubble Chamber

    DOE R&D Accomplishments Database

    Alvarez, L. W.; Gow, J. D.; Barrera, F.; Eckman, G.; Shand, J.; Watt, R.; Norgren, D.; Hernandez, H. P.

    1964-07-08

    The recently completed 25-inch hydrogen bubble chamber combines excellent picture quality with a fast operating cycle. The chamber has a unique optical system and is designed to take several pictures each Bevatron pulse, in conjunction with the Bevatron rapid beam ejection system.

  15. Neutron Detection via Bubble Chambers

    SciTech Connect

    Jordan, David V.; Ely, James H.; Peurrung, Anthony J.; Bond, Leonard J.; Collar, J. I.; Flake, Matthew; Knopf, Michael A.; Pitts, W. K.; Shaver, Mark W.; Sonnenschein, Andrew; Smart, John E.; Todd, Lindsay C.

    2005-10-06

    The results of a Pacific Northwest National Laboratory (PNNL) exploratory research project investigating the feasibility of fast neutron detection using a suitably prepared and operated, pressure-cycled bubble chamber are described. The research was conducted along two parallel paths. Experiments with a slow pressure-release Halon chamber at the Enrico Fermi Institute at the University of Chicago showed clear bubble nucleation sensitivity to an AmBe neutron source and insensitivity to the 662 keV gammas from a 137Cs source. Bubble formation was documented via high-speed (1000 frames/sec) photography, and the acoustic signature of bubble formation was detected using a piezo-electric transducer element mounted on the base of the chamber. The chamber’s neutron sensitivity as a function of working fluid temperature was mapped out. The second research path consisted of the design, fabrication, and testing of a fast pressure-release Freon-134a chamber at PNNL. The project concluded with successful demonstrations of the PNNL chamber’s AmBe neutron source sensitivity and 137Cs gamma insensitivity. The source response tests of the PNNL chamber were documented with high-speed photography.

  16. Ice bubbles confirm big chill

    SciTech Connect

    Kerr, R.A.

    1996-06-14

    Clues buried in Greenland`s icesheet indicate that during the last ice age, the climate repeatedly warmed sharply, only to slide into a renewed chill lasting thousands of years. New indicators derived from trapped bubbles of ancient gases, nitrogen and methane, indicate that these were indeed catastrophic events. This article describes the research and adjunct issues.

  17. Bubble-driven inertial micropump

    NASA Astrophysics Data System (ADS)

    Torniainen, Erik D.; Govyadinov, Alexander N.; Markel, David P.; Kornilovitch, Pavel E.

    2012-12-01

    The fundamental action of the bubble-driven inertial micropump is investigated. The pump has no moving parts and consists of a thermal resistor placed asymmetrically within a straight channel connecting two reservoirs. Using numerical simulations, the net flow is studied as a function of channel geometry, resistor location, vapor bubble strength, fluid viscosity, and surface tension. Two major regimes of behavior are identified: axial and non-axial. In the axial regime, the drive bubble either remains inside the channel, or continues to grow axially when it reaches the reservoir. In the non-axial regime, the bubble grows out of the channel and in all three dimensions while inside the reservoir. The net flow in the axial regime is parabolic with respect to the hydraulic diameter of the channel cross-section, but in the non-axial regime it is not. From numerical modeling, it is determined that the net flow is maximal when the axial regime crosses over to the non-axial regime. To elucidate the basic physical principles of the pump, a phenomenological one-dimensional model is developed and solved. A linear array of micropumps has been built using silicon-SU8 fabrication technology that is used to manufacture thermal inkjet printheads. Semi-continuous pumping across a 2 mm-wide channel has been demonstrated experimentally. Measured net flow with respect to viscosity variation is in excellent agreement with simulation results.

  18. "Financial Bubbles" and Monetary Policy

    ERIC Educational Resources Information Center

    Tikhonov, Yuriy A.; Pudovkina, Olga E.; Permjakova, Juliana V.

    2016-01-01

    The relevance of this research is caused by the need of strengthening a role of monetary regulators to prevent financial bubbles in the financial markets. The aim of the article is the analysis of a problem of crisis phenomena in the markets of financial assets owing to an inadequate growth of their cost, owing to subjective reasons. The leading…

  19. Nonlinear bubble dynamics of cavitation.

    PubMed

    An, Yu

    2012-01-01

    For cavitation clouds generated in a standing sound wave driven by an ultrasonic horn, the nonlinear acoustic wave equation governing cavitation dynamics is numerically solved together with the bubble motion equation under an approximation. This conceptual calculation can qualitatively reproduce the observed characteristics of cavitation.

  20. Models of cylindrical bubble pulsation

    PubMed Central

    Ilinskii, Yurii A.; Zabolotskaya, Evgenia A.; Hay, Todd A.; Hamilton, Mark F.

    2012-01-01

    Three models are considered for describing the dynamics of a pulsating cylindrical bubble. A linear solution is derived for a cylindrical bubble in an infinite compressible liquid. The solution accounts for losses due to viscosity, heat conduction, and acoustic radiation. It reveals that radiation is the dominant loss mechanism, and that it is 22 times greater than for a spherical bubble of the same radius. The predicted resonance frequency provides a basis of comparison for limiting forms of other models. The second model considered is a commonly used equation in Rayleigh-Plesset form that requires an incompressible liquid to be finite in extent in order for bubble pulsation to occur. The radial extent of the liquid becomes a fitting parameter, and it is found that considerably different values of the parameter are required for modeling inertial motion versus acoustical oscillations. The third model was developed by V. K. Kedrinskii [Hydrodynamics of Explosion (Springer, New York, 2005), pp. 23–26] in the form of the Gilmore equation for compressible liquids of infinite extent. While the correct resonance frequency and loss factor are not recovered from this model in the linear approximation, it provides reasonable agreement with observations of inertial motion. PMID:22978863

  1. Bursting the Taylor cone bubble

    NASA Astrophysics Data System (ADS)

    Pan, Zhao; Truscott, Tadd

    2014-11-01

    A soap bubble fixed on a surface and placed in an electric field will take on the shape of a cone rather than constant curvature (dome) when the electrical field is not present. The phenomenon was introduced by J. Zeleny (1917) and studied extensively by C.T. Wilson & G.I. Taylor (1925). We revisit the Taylor cone problem by studying the deformation and bursting of soap bubbles in a point charge electric field. A single bubble takes on the shape of a cone in the electric field and a high-speed camera equipped with a micro-lens is used to observe the unsteady dynamics at the tip. Rupture occurs as a very small piece of the tip is torn away from the bubble toward the point charge. Based on experiments, a theoretical model is developed that predicts when rupture should occur. This study may help in the design of foam-removal techniques in engineering and provide a better understanding of an electrified air-liquid interface.

  2. Impurity bubbles in a BEC

    NASA Astrophysics Data System (ADS)

    Timmermans, Eddy; Blinova, Alina; Boshier, Malcolm

    2013-05-01

    Polarons (particles that interact with the self-consistent deformation of the host medium that contains them) self-localize when strongly coupled. Dilute Bose-Einstein condensates (BECs) doped with neutral distinguishable atoms (impurities) and armed with a Feshbach-tuned impurity-boson interaction provide a unique laboratory to study self-localized polarons. In nature, self-localized polarons come in two flavors that exhibit qualitatively different behavior: In lattice systems, the deformation is slight and the particle is accompanied by a cloud of collective excitations as in the case of the Landau-Pekar polarons of electrons in a dielectric lattice. In natural fluids and gases, the strongly coupled particle radically alters the medium, e.g. by expelling the host medium as in the case of the electron bubbles in superfluid helium. We show that BEC-impurities can self-localize in a bubble, as well as in a Landau-Pekar polaron state. The BEC-impurity system is fully characterized by only two dimensionless coupling constants. In the corresponding phase diagram the bubble and Landau-Pekar polaron limits correspond to large islands separated by a cross-over region. The same BEC-impurity species can be adiabatically Feshbach steered from the Landau-Pekar to the bubble regime. This work was funded by the Los Alamos LDRD program.

  3. The Coming Law School Bubble

    ERIC Educational Resources Information Center

    Krauss, Michael I.

    2011-01-01

    In this article, the author explains how forty years of politicized hiring in the law schools has left its destructive mark. The results are potentially catastrophic: Market forces and internal law school policies may be combining to produce a legal education bubble the likes of which the country has never seen. (Contains 11 footnotes.)

  4. Affirmative Discrimination and the Bubble

    ERIC Educational Resources Information Center

    Clegg, Roger

    2011-01-01

    In this essay, the author discusses how affirmative action contributed to an unnatural rise in enrollments in college. In considering the higher education bubble, he makes the case that as the opposition to preferences continues to build, the momentum of this trend will only increase as funding shrinks. He offers some tentative answers to a series…

  5. Nanofluidic interfaces in microfluidic networks

    DOE PAGES

    Millet, Larry J.; Doktycz, Mitchel John; Retterer, Scott T.

    2015-09-24

    The integration of nano- and microfluidic technologies enables the construction of tunable interfaces to physical and biological systems across relevant length scales. The ability to perform chemical manipulations of miniscule sample volumes is greatly enhanced through these technologies and extends the ability to manipulate and sample the local fluidic environments at subcellular, cellular and community or tissue scales. Here we describe the development of a flexible surface micromachining process for the creation of nanofluidic channel arrays integrated within SU-8 microfluidic networks. The use of a semi-porous, silicon rich, silicon nitride structural layer allows rapid release of the sacrificial silicon dioxidemore » during the nanochannel fabrication. Nanochannel openings that form the interface to biological samples are customized using focused ion beam milling. The compatibility of these interfaces with on-chip microbial culture is demonstrated.« less

  6. Nanofluidic interfaces in microfluidic networks

    SciTech Connect

    Millet, Larry J.; Doktycz, Mitchel John; Retterer, Scott T.

    2015-09-24

    The integration of nano- and microfluidic technologies enables the construction of tunable interfaces to physical and biological systems across relevant length scales. The ability to perform chemical manipulations of miniscule sample volumes is greatly enhanced through these technologies and extends the ability to manipulate and sample the local fluidic environments at subcellular, cellular and community or tissue scales. Here we describe the development of a flexible surface micromachining process for the creation of nanofluidic channel arrays integrated within SU-8 microfluidic networks. The use of a semi-porous, silicon rich, silicon nitride structural layer allows rapid release of the sacrificial silicon dioxide during the nanochannel fabrication. Nanochannel openings that form the interface to biological samples are customized using focused ion beam milling. The compatibility of these interfaces with on-chip microbial culture is demonstrated.

  7. Viscosimeter on a microfluidic chip.

    PubMed

    Guillot, Pierre; Panizza, Pascal; Salmon, Jean-Baptiste; Joanicot, Mathieu; Colin, Annie; Bruneau, Charles-Henri; Colin, Thierry

    2006-07-01

    In this work, a viscosimeter implemented on a microfluidic chip is presented. The physical principle of this system is to use laminar parallel flows in a microfluidic channel. The fluid to be studied flows side by side with a reference fluid of known viscosity. By using optical microscopy, the shape of the interface between both fluids can be determined. Knowing the flow rates of the two liquids and the geometrical features of the channel, the mean shear rate sustained by the fluid and its viscosity can thus be computed. Accurate and precise measurements of the viscosity as a function of the shear rate can be made using less than 300 microL of fluid. Several complex fluids are tested with viscosities ranging from 10(-)(3) to 70 Pa.s.

  8. Self-assembly via microfluidics.

    PubMed

    Wang, Lei; Sánchez, Samuel

    2015-12-01

    The self-assembly of amphiphilic building blocks has attracted extensive interest in myriad fields in recent years, due to their great potential in the nanoscale design of functional hybrid materials. Microfluidic techniques provide an intriguing method to control kinetic aspects of the self-assembly of molecular amphiphiles by the facile adjustment of the hydrodynamics of the fluids. Up to now, there have been several reports about one-step direct self-assembly of different building blocks with versatile and multi-shape products without templates, which demonstrated the advantages of microfluidics. These assemblies with different morphologies have great applications in various areas such as cancer therapy, micromotor fabrication, and controlled drug delivery.

  9. Liquid dielectrophoresis and surface microfluidics

    PubMed Central

    Kaler, Karan V. I. S.; Prakash, Ravi; Chugh, Dipankar

    2010-01-01

    Liquid dielectrophoresis (L-DEP), when deployed at microscopic scales on top of hydrophobic surfaces, offers novel ways of rapid and automated manipulation of very small amounts of polar aqueous samples for microfluidic applications and development of laboratory-on-a-chip devices. In this article we highlight some of the more recent developments and applications of L-DEP in handling and processing of various types of aqueous samples and reagents of biological relevance including emulsions using such microchip based surface microfluidic (SMF) devices. We highlighted the utility of these devices for on-chip bioassays including nucleic acid analysis. Furthermore, the parallel sample processing capabilities of these SMF devices together with suitable on- or off-chip detection capabilities suggest numerous applications and utility in conducting automated multiplexed assays, a capability much sought after in the high throughput diagnostic and screening assays. PMID:20697595

  10. The self-regulated AGN feedback loop: the role of chaotic cold accretion

    NASA Astrophysics Data System (ADS)

    Gaspari, Massimo

    2015-08-01

    Accretion and feedback tied to supermassive black holes are known to play central role in the cosmic evolution of galaxies, groups, and clusters of galaxies. The self-regulation mechanism, that is how to link feedback and accretion, is matter of intense debate.Using high-resolution 3D hydrodynamic simulations, I discuss how the AGN feedback is tightly coupled with the formation of multiphase gas and the newly probed chaotic cold accretion. In a turbulent atmosphere heated by AGN feedback, cold clouds and filaments condense out of the hot plasma via nonlinear thermal instability, up to radii of 10s kpc, and rain toward the black hole. In the inner core, the recurrent chaotic collisions between the cold clouds, filaments, and central torus promote angular momentum cancellation, boosting the accretion rate up to 100 times the Bondi rate, which is comparable to the cooling rate.Such rapid variability triggers powerful AGN outflows, which quench the cooling flow and star formation without destroying the cool core. I highlight the major imprints of mechanical AGN feedback, such as buoyant bubbles, shocks, turbulence, and uplifted gas, with a critical eye toward concordance with X-ray observations. The tight self-regulation has key implications for the group/cluster scaling relations, such as Lx-Tx, in agreement with a recent X-ray stacking analysis of 250000 central galaxies.The AGN heating stifles the formation of multiphase gas, and thus accretion. Lacking the main fuel, AGN feedback subsides and the hot halo is allowed to cool again, restarting a new cycle. Ultimately, chaotic cold accretion creates a symbiotic link between the black hole and the whole host galaxy, leading to a tight self-regulated feedback loop which preserves the cores of groups and clusters in quasi thermal equilibrium throughout cosmic time.

  11. The self-regulated AGN feedback loop: the role of chaotic cold accretion

    NASA Astrophysics Data System (ADS)

    Gaspari, Massimo

    2015-08-01

    Accretion and feedback tied to supermassive black holes are known to play central role in the cosmic evolution of galaxies, groups, and clusters of galaxies. The self-regulation mechanism, that is how to link feedback and accretion, is matter of intense debate.Using high-resolution 3D hydrodynamic simulations, I discuss how the AGN feedback is tightly coupled with the formation of multiphase gas and the newly probed chaotic cold accretion. In a turbulent atmosphere heated by AGN feedback, cold clouds and filaments condense out of the hot plasma via nonlinear thermal instability, up to radii of 10s kpc, and rain toward the black hole. In the inner core, the recurrent chaotic collisions between the cold clouds, filaments, and central torus promote angular momentum cancellation, boosting the accretion rate up to 100 times the Bondi rate, which is comparable to the cooling rate.Such rapid variability triggers powerful AGN outflows, which quench the cooling flow and star formation without destroying the cool core. I highlight the major imprints of mechanical AGN feedback, such as buoyant bubbles, shocks, turbulence, and uplifted gas, with a critical eye toward observational concordance. The tight self-regulation has key implications for the group/cluster scaling relations, such as Lx-Tx, in agreement with a recent X-ray stacking analysis of 250000 central galaxies.The AGN heating stifles the formation of multiphase gas, and thus accretion. Lacking the main fuel, AGN feedback subsides and the hot halo is allowed to cool again, restarting a new cycle. Ultimately, chaotic cold accretion creates a symbiotic link between the black hole and the whole host galaxy, leading to a tight self-regulated feedback loop which preserves the cores of groups and clusters in quasi thermal equilibrium throughout cosmic time.

  12. The self-regulated AGN feedback loop: the role of chaotic cold accretion

    NASA Astrophysics Data System (ADS)

    Gaspari, Massimo

    2015-08-01

    Accretion and feedback tied to supermassive black holes are known to play central role in the cosmic evolution of galaxies, groups, and clusters of galaxies. The self-regulation mechanism, that is how to link feedback and accretion, is matter of intense debate.Using high-resolution 3D hydrodynamic simulations, I discuss how the AGN feedback is tightly coupled with the formation of multiphase gas and the newly probed chaotic cold accretion. In a turbulent atmosphere heated by AGN feedback, cold clouds and filaments condense out of the hot plasma via nonlinear thermal instability, up to radii of 10s kpc, and rain toward the black hole. In the inner core, the recurrent chaotic collisions between the cold clouds, filaments, and central torus promote angular momentum cancellation, boosting the accretion rate up to 100 times the Bondi rate, which is comparable to the cooling rate.Such rapid variability triggers powerful AGN outflows, which quench the cooling flow and star formation without destroying the cool core. I highlight the major imprints of mechanical AGN feedback, such as buoyant bubbles, shocks, turbulence, and uplifted gas, with a critical eye toward observational concordance. The tight self-regulation has key implications for the scaling relations, such as Lx-Tx, and the X-ray spectrum of hot halos.The AGN heating stifles the formation of multiphase gas, and thus accretion. Lacking the main fuel, AGN feedback subsides and the hot halo is allowed to cool again, restarting a new cycle. Ultimately, chaotic cold accretion creates a symbiotic link between the black hole and the whole host galaxy, leading to a tight self-regulated feedback loop which preserves the cores of groups and clusters in quasi thermal equilibrium throughout cosmic time.

  13. Integrating plasmonic diagnostics and microfluidics

    PubMed Central

    Niu, Lifang; Zhang, Nan; Liu, Hong; Zhou, Xiaodong; Knoll, Wolfgang

    2015-01-01

    Plasmonics is generally divided into two categories: surface plasmon resonance (SPR) of electromagnetic modes propagating along a (noble) metal/dielectric interface and localized SPRs (LSPRs) on nanoscopic metallic structures (particles, rods, shells, holes, etc.). Both optical transducer concepts can be combined with and integrated in microfluidic devices for biomolecular analyte detections, with the benefits of small foot-print for point-of-care detection, low-cost for one-time disposal, and ease of being integrated into an array format. The key technologies in such integration include the plasmonic chip, microfluidic channel fabrication, surface bio-functionalization, and selection of the detection scheme, which are selected according to the specifics of the targeting analytes. This paper demonstrates a few examples of the many versions of how to combine plasmonics and integrated microfluidics, using different plasmonic generation mechanisms for different analyte detections. One example is a DNA sensor array using a gold film as substrate and surface plasmon fluorescence spectroscopy and microscopy as the transduction method. This is then compared to grating-coupled SPR for poly(ethylene glycol) thiol interaction detected by angle interrogation, gold nanohole based LSPR chip for biotin-strepavidin detection by wavelength shift, and gold nanoholes/nanopillars for the detection of prostate specific antigen by quantum dot labels excited by the LSPR. Our experimental results exemplified that the plasmonic integrated microfluidics is a promising tool for understanding the biomolecular interactions and molecular recognition process as well as biosensing, especially for on-site or point-of-care diagnostics. PMID:26392832

  14. Multidimensional bioseparation with modular microfluidics

    DOEpatents

    Chirica, Gabriela S.; Renzi, Ronald F.

    2013-08-27

    A multidimensional chemical separation and analysis system is described including a prototyping platform and modular microfluidic components capable of rapid and convenient assembly, alteration and disassembly of numerous candidate separation systems. Partial or total computer control of the separation system is possible. Single or multiple alternative processing trains can be tested, optimized and/or run in parallel. Examples related to the separation and analysis of human bodily fluids are given.

  15. Acoustically-driven microfluidic systems

    SciTech Connect

    Wang, A W; Benett, W J; Tarte, L R

    2000-06-23

    We have demonstrated a non-contact method of concentrating and mixing particles in a plastic microfluidic chamber employing acoustic radiation pressure. A flaw cell package has also been designed that integrates liquid sample interconnects, electrical contacts and a removable sample chamber. Experiments were performed on 1, 3, 6, and 10 {micro}m polystyrene beads. Increased antibody binding to a solid-phase substrate was observed in the presence of acoustic mixing due to improve mass transport.

  16. Tiny Bubbles in my BEC

    SciTech Connect

    Blinova, Alina A.

    2012-08-01

    Ultracold atomic gases provide a unique way for exploring many-body quantum phenomena that are inaccessible to conventional low-temperature experiments. Nearly two decades ago the Bose-Einstein condensate (BEC) - an ultracold gas of bosons in which almost all bosons occupy the same single-particle state - became experimentally feasible. Because a BEC exhibits superfluid properties, it can provide insights into the behavior of low-temperature helium liquids. We describe the case of a single distinguishable atom (an impurity) embedded in a BEC and strongly coupled to the BEC bosons. Depending on the strength of impurity-boson and boson-boson interactions, the impurity self-localizes into two fundamentally distinct regimes. The impurity atom can behave as a tightly localized 'polaron,' akin to an electron in a dielectric crystal, or as a 'bubble,' an analog to an electron bubble in superfluid helium. We obtain the ground state wavefunctions of the impurity and BEC by numerically solving the two coupled Gross-Pitaevskii equations that characterize the system. We employ the methods of imaginary time propagation and conjugate gradient descent. By appropriately varying the impurity-boson and boson-boson interaction strengths, we focus on the polaron to bubble crossover. Our results confirm analytical predictions for the polaron limit and uncover properties of the bubble regime. With these results we characterize the polaron to bubble crossover. We also summarize our findings in a phase diagram of the BEC-impurity system, which can be used as a guide in future experiments.

  17. Virtual Libraries: Interactive Support Software and an Application in Chaotic Models.

    ERIC Educational Resources Information Center

    Katsirikou, Anthi; Skiadas, Christos; Apostolou, Apostolos; Rompogiannakis, Giannis

    This paper begins with a discussion of the characteristics and the singularity of chaotic systems, including dynamic systems theory, chaotic orbit, fractals, chaotic attractors, and characteristics of chaotic systems. The second section addresses the digital libraries (DL) concept and the appropriateness of chaotic models, including definition and…

  18. Supercoiling induces denaturation bubbles in circular DNA.

    PubMed

    Jeon, Jae-Hyung; Adamcik, Jozef; Dietler, Giovanni; Metzler, Ralf

    2010-11-12

    We present a theoretical framework for the thermodynamic properties of supercoiling-induced denaturation bubbles in circular double-stranded DNA molecules. We explore how DNA supercoiling, ambient salt concentration, and sequence heterogeneity impact on the bubble occurrence. An analytical derivation of the probability distribution to find multiple bubbles is derived and the relevance for supercoiled DNA discussed. We show that in vivo sustained DNA bubbles are likely to occur due to partial twist release in regions rich in weaker AT base pairs. Single DNA plasmid imaging experiments clearly demonstrate the existence of bubbles in free solution.

  19. Mesoporous hollow spheres from soap bubbling.

    PubMed

    Yu, Xianglin; Liang, Fuxin; Liu, Jiguang; Lu, Yunfeng; Yang, Zhenzhong

    2012-02-01

    The smaller and more stable bubbles can be generated from the large parent bubbles by rupture. In the presence of a bubble blowing agent, hollow spheres can be prepared by bubbling a silica sol. Herein, the trapped gas inside the bubble acts as a template. When the porogen, i.e., other surfactant, is introduced, a mesostructured shell forms by the co-assembly with the silica sol during sol-gel process. Morphological evolution emphasizes the prerequisite of an intermediate interior gas flow rate and high exterior gas flow rate for hollow spheres. The method is valid for many compositions from inorganic, polymer to their composites. PMID:22078340

  20. Mesoporous hollow spheres from soap bubbling.

    PubMed

    Yu, Xianglin; Liang, Fuxin; Liu, Jiguang; Lu, Yunfeng; Yang, Zhenzhong

    2012-02-01

    The smaller and more stable bubbles can be generated from the large parent bubbles by rupture. In the presence of a bubble blowing agent, hollow spheres can be prepared by bubbling a silica sol. Herein, the trapped gas inside the bubble acts as a template. When the porogen, i.e., other surfactant, is introduced, a mesostructured shell forms by the co-assembly with the silica sol during sol-gel process. Morphological evolution emphasizes the prerequisite of an intermediate interior gas flow rate and high exterior gas flow rate for hollow spheres. The method is valid for many compositions from inorganic, polymer to their composites.