Sample records for miidel riko noormets

  1. 76 FR 65501 - Procurement List Additions

    Federal Register 2010, 2011, 2012, 2013, 2014


    ... INFORMATION: Additions On 8/19/2011 (76 FR 51955-51956) and 8/26/2011 (76 FR 53419-53420), the Committee for..., FA8751 AFRL RIKO, Rome, NY. Patricia Briscoe, Deputy Director, Business Operations, Pricing...

  2. Decay-accelerating factor induction by tumour necrosis factor-alpha, through a phosphatidylinositol-3 kinase and protein kinase C-dependent pathway, protects murine vascular endothelial cells against complement deposition.


    Ahmad, Saifur R; Lidington, Elaine A; Ohta, Rieko; Okada, Noriko; Robson, Michael G; Davies, Kevin A; Leitges, Michael; Harris, Claire L; Haskard, Dorian O; Mason, Justin C


    We have shown that human endothelial cells (EC) are protected against complement-mediated injury by the inducible expression of decay-accelerating factor (DAF). To understand further the importance of DAF regulation, we characterized EC DAF expression on murine EC in vitro and in vivo using a model of glomerulonephritis. Flow cytometry using the monoclonal antibody (mAb) Riko-3 [binds transmembrane- and glycosylphosphatidylinositol (GPI)-anchored DAF], mAb Riko-4 (binds GPI-anchored DAF) and reverse transcription-polymerase chain reaction (RT-PCR), demonstrated that murine EC DAF is GPI-anchored. Tumour necrosis factor-alpha (TNF-alpha) increased EC DAF expression, detectable at 6 hr and maximal at 24-48 hr poststimulation. DAF upregulation required increased steady-state DAF mRNA and protein synthesis. In contrast, no increased expression of the murine complement receptor-related protein-Y (Crry) was seen with TNF-alpha. DAF upregulation was mediated via a protein kinase C (PKC)alpha, phosphoinositide-3 kinase (PI-3 kinase), p38 mitogen-activated protein kinase (MAPK) and nuclear factor-kappaB (NF-kappaB)-dependent pathway. The increased DAF was functionally relevant, resulting in a marked reduction in C3 deposition following complement activation. In a nephrotoxic nephritis model, DAF expression on glomerular capillaries was significantly increased 2 hr after the induction of disease. The demonstration of DAF upregulation above constitutive levels suggests that this may be important in the maintenance of vascular integrity during inflammation, when the risk of complement-mediated injury is increased. The mouse represents a suitable model for the study of novel therapeutic approaches by which vascular endothelium may be conditioned against complement-mediated injury.

  3. Gapfilling strategies in difficult situations: long gaps, discontinuities, switch and pulses

    NASA Astrophysics Data System (ADS)

    Trotta, C.; Papale, D.


    , J. H. Gove, M. Heimann, D. Hui, A. J. Jarvis, J. Kattge, A. Noormets, and V. J. Stauch. 2007. Comprehensive comparison of gap-filling techniques for eddy covariance net carbon fluxes. Agricultural and Forest Meteorology 147:209-232.

  4. Sectoral Vulnerabilities to Changing Water Resources: Current and Future Tradeoffs between Supply and Demand in the Conterminous U.S

    NASA Astrophysics Data System (ADS)

    Meldrum, J.; Averyt, K.; Caldwell, P.; Sun, G.; Huber-lee, A. T.; McNulty, S.


    ., Rogers, J., and Tellinghuisen, S. 2011. Freshwater use by US power plants: electricity's thirst for a precious resource. A report of the Energy and Water in a Warming World initiative, Cambridge, MA: Union of Concerned Scientists, 52 pp. Caldwell, P., Sun, G., McNulty, S., Cohen, E., and Moore Myers, J. 2011. Modeling Impacts of Environmental Change on Ecosystem Services across the Conterminous United States, in: Proceedings of the Fourth Interagency Conference on Research in the Watersheds, Fairbanks, AK, 26-30 Sept 2011, 63-69. Kenny, J., Barber, N., Hutson, S., Linsey, K., Lovelace, J., and Maupin, M. 2009. Estimated use of water in the United States in 2005. US Geological Survey Circular 1344, 52 pp. Milly, P. C. D., Dunne, K. A., and Vecchia, A. V. 2005. Global pattern of trends in streamflow and water availability in a changing climate. Nature 438(7066):347-350. Sun, G., McNulty, S., Moore Myers, J., and Cohen, E. 2008. Impacts of multiple stresses on water demand and supply across the Southeastern United States. Journal of American Water Resources Association 44(6):1441-1457. Sun, G., Caldwell, P., Noormets, A., Cohen, E., McNulty, S., Treasure, E., Domec, J., Mu, Q., Xiao, J., John, R., and Chen, J. 2011. Upscaling key ecosystem functions across the Conterminous United States by a water-centric ecosystem model, J. Geophys. Res., 116.

  5. Comparison of publically available Moho depth and crustal thickness grids with newly derived grids by 3D gravity inversion for the High Arctic region.

    NASA Astrophysics Data System (ADS)

    Lebedeva-Ivanova, Nina; Gaina, Carmen; Minakov, Alexander; Kashubin, Sergey


    deep Arctic Ocean: results of a 3D gravity modeling Russian Geology and Geophysics 54, 247-262. Jakobsson M, Mayer L, Coakley B, Dowdeswell JA, Forbes S, Fridman B, Hodnesdal H, Noormets R, Pedersen R, Rebesco M, Schenke HW, Zarayskaya Y, Accettella D, Armstrong A, Anderson RM, Bienhoff P, Camerlenghi A, Church I, Edwards M, Gardner JV, Hall JK, Hell B, Hestvik O, Krist-offersen Y, Marcussen C, Mohammad R, Mosher D, Nghiem SV, Pedrosa MT, Travaglini PG, Weatherall P (2012). The international bathymetric chart of the Arctic Ocean (IBCAO) version 3.0. Geophys Res Lett 39, L12609. Laske, G., Masters., G., Ma, Z. and Pasyanos, M. (2013). Update on CRUST1.0 - A 1-degree Global Model of Earth's Crust, Geophys. Res. Abstracts, 15, Abstract EGU2013-2658, 2013. Minakov A, Faleide JI, Glebovsky VY, Mjelde R (2012) Structure and evolution of the northern Barents-Kara Sea continental margin from integrated analysis of potential fields, bathymetry and sparse seismic data. Geophys J Int 188, 79-102. Petrov O., Smelror M., Shokalsky S., Morozov A., Kashubin S., Grikurov G., Sobolev N., Petrov E., (2013). A new international tectonic map of the Arctic (TeMAr) at 1:5 M scale and geodynamic evolution in the Arctic region. EGU2013-13481. Reguzzoni, M., & Sampietro, D. (2014). GEMMA: An Earth crustal model based on GOCE satellite data. International Journal of Applied Earth Observation and Geoinformation Spasojevic S. & Gurnis M., (2012). Sea level and vertical motion of continents from dynamic earth models since the late Cretaceous. American Association of Petroleum Geologists Bulletin, 96, pp. 2037-2064.