...: Grounds Maintenance, Air Force Research Laboratory Stockbridge Test Facility, 5251 Burleson Road, Oneida..., FA8751 AFRL RIKO, Rome, NY. Patricia Briscoe, Deputy Director, Business Operations, Pricing...
...., Farmville, VA. Service Type/Location: Grounds Maintenance, Air Force Research Laboratory Stockbridge Test... Activity: Dept. of the Air Force, FA8751 AFRL RIKO, Rome, NY. Patricia Briscoe, Deputy Director,...
Sun, Raphael C.; Diaz-Miron, Jose L.; Choi, Pamela M.; Sommovilla, Joshua; Guo, Jun; Erwin, Christopher R.; Warner, Brad W.
Purpose Intestinal adaptation structurally represents increases in crypt depth and villus height in response to small bowel resection (SBR). Previously, we found that neither epidermal growth factor receptor (EGFR) nor insulin-like growth factor 1 receptor (IGF1R) function was individually required for normal adaptation. In this study, we sought to determine the effect of disrupting both EGFR and IGF1R expression on resection-induced adaptation. Methods Intestinal-specific EGFR and IGF1R double knockout mice (EGFR/IGF1R-IKO) (n=6) and wild-type (WT) control mice (n=7) underwent 50% proximal SBR. On postoperative day (POD) 7, structural adaptation was scored by measuring crypt depth and villus height. Rates of crypt cell proliferation, apoptosis, and submucosal capillary density were also compared. Results After 50% SBR, normal adaptation occurred in both WT and EGFR/IGF1R-IKO. Rates of proliferation and apoptosis were no different between the two groups. The angiogenic response was less in the EGFR/IGF1R-IKO compared to WT mice. Conclusion Disrupted expression of EGFR and IGF1R in the intestinal epithelial cells does not affect resection-induced structural adaptation but attenuates angiogenesis after SBR. These findings suggest that villus growth is driven by receptors and pathways that occur outside the epithelial cell component, while angiogenic responses may be influenced by epithelial-endothelial crosstalk. PMID:25818318
Trotta, C.; Papale, D.
, J. H. Gove, M. Heimann, D. Hui, A. J. Jarvis, J. Kattge, A. Noormets, and V. J. Stauch. 2007. Comprehensive comparison of gap-filling techniques for eddy covariance net carbon fluxes. Agricultural and Forest Meteorology 147:209-232.
Meldrum, J.; Averyt, K.; Caldwell, P.; Sun, G.; Huber-lee, A. T.; McNulty, S.
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Lebedeva-Ivanova, Nina; Gaina, Carmen; Minakov, Alexander; Kashubin, Sergey
deep Arctic Ocean: results of a 3D gravity modeling Russian Geology and Geophysics 54, 247-262. Jakobsson M, Mayer L, Coakley B, Dowdeswell JA, Forbes S, Fridman B, Hodnesdal H, Noormets R, Pedersen R, Rebesco M, Schenke HW, Zarayskaya Y, Accettella D, Armstrong A, Anderson RM, Bienhoff P, Camerlenghi A, Church I, Edwards M, Gardner JV, Hall JK, Hell B, Hestvik O, Krist-offersen Y, Marcussen C, Mohammad R, Mosher D, Nghiem SV, Pedrosa MT, Travaglini PG, Weatherall P (2012). The international bathymetric chart of the Arctic Ocean (IBCAO) version 3.0. Geophys Res Lett 39, L12609. Laske, G., Masters., G., Ma, Z. and Pasyanos, M. (2013). Update on CRUST1.0 - A 1-degree Global Model of Earth's Crust, Geophys. Res. Abstracts, 15, Abstract EGU2013-2658, 2013. Minakov A, Faleide JI, Glebovsky VY, Mjelde R (2012) Structure and evolution of the northern Barents-Kara Sea continental margin from integrated analysis of potential fields, bathymetry and sparse seismic data. Geophys J Int 188, 79-102. Petrov O., Smelror M., Shokalsky S., Morozov A., Kashubin S., Grikurov G., Sobolev N., Petrov E., (2013). A new international tectonic map of the Arctic (TeMAr) at 1:5 M scale and geodynamic evolution in the Arctic region. EGU2013-13481. Reguzzoni, M., & Sampietro, D. (2014). GEMMA: An Earth crustal model based on GOCE satellite data. International Journal of Applied Earth Observation and Geoinformation Spasojevic S. & Gurnis M., (2012). Sea level and vertical motion of continents from dynamic earth models since the late Cretaceous. American Association of Petroleum Geologists Bulletin, 96, pp. 2037-2064.