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Sample records for milieu acetique tamponne

  1. Relaxation Assessment with Varied Structured Milieu (RELAX).

    ERIC Educational Resources Information Center

    Cassel, Russell N.; Cassel, Susie L.

    1983-01-01

    Describes Relaxation Assessment with Varied Structured Milieu (RELAX), a clinical program designed to assess the degree to which an individual is able to demonstrate self-control for overall general relaxation. The program is designed for use with the Cassel Biosensors biofeedback equipment. (JAC)

  2. Using the Milieu: Treatment-Environment Consistency.

    ERIC Educational Resources Information Center

    Szekais, Barbara

    1985-01-01

    Describes trial use of milieu and activity-based therapy in two adult day centers to increase client involvement in physical and social environments of treatment settings. Reports results from empirical observations and recommends further investigation of this treatment modality in settings for the elderly. (Author/NRB)

  3. Social Allostasis: Anticipatory Regulation of the Internal Milieu

    PubMed Central

    Schulkin, Jay

    2010-01-01

    Social regulation of the internal milieu is a fundamental behavioral adaptation. Cephalic capability is reflected by anticipatory behaviors to serve systemic physiological regulation. Homeostatic regulation, a dominant perspective, reflects reactive responses; allostatic regulation, the physiology of change, emphasizes longer-term anticipatory, and feedforward systems. Steroids, such as cortisol, and peptides such as corticotrophin releasing hormone are but one example of such anticipatory regulatory systems. The concept of “allostasis” is in part to take account of anticipatory control amidst diverse forms of adaptation underlying this regulatory adaptation that supports social contact and the internal milieu. PMID:21369352

  4. DEVELOPING EGO FUNCTIONS IN DISTURBED CHILDREN, OCCUPATIONAL THERAPY IN MILIEU.

    ERIC Educational Resources Information Center

    LLORENS, LELA A.; RUBIN, ELI Z.

    THE USE OF OCCUPATIONAL THERAPY (OT) WITH EMOTIONALLY DISTURBED CHILDREN IN A RESIDENTIAL TREATMENT SETTING OR MILIEU IS DESCRIBED ON THE BASIS OF 6 YEARS OF EXPERIMENTAL WORK. CORRECTIVE TREATMENT AND REHABILITATION APPROACHES ARE EXPLAINED. ALSO CONSIDERED IS THE CONTRIBUTION OF OT IN (1) THE DEVELOPMENT, FULFILLMENT, OR MODIFICATION OF MOTOR…

  5. Amelioration of transference resistance: substitute therapists in milieu group psychotherapy.

    PubMed

    Sperling, M B; Kibel, H D; Loutsch, E M

    1990-01-01

    Building upon Wolf's (1949) notion of the use of an alternate session in group psychotherapy, this paper suggests that an alternate therapist substituting for an absent regular therapist in milieu group psychotherapy can facilitate similar therapeutic benefits. The mechanism of this process of overcoming transference resistance is seen as twofold: (1) sessions with a substitute therapist allow patients to confront the infantilization often present in a milieu setting and experiment with more autonomous ego functioning. (2) Sessions with a substitute therapist create conditions which are apart from the ongoing process of the therapy group, thereby allowing for a therapeutic splitting process to develop wherein transference feelings about the regular therapist can be expressed to his or her "alter ego." Several case vignettes are presented in order to illustrate the clinical utility of a substitute therapist.

  6. Bioinspired assembly of small molecules in cell milieu.

    PubMed

    Wang, Huaimin; Feng, Zhaoqianqi; Xu, Bing

    2017-03-30

    Self-assembly, the autonomous organization of components to form patterns or structures, is a prevalent process in nature at all scales. Particularly, biological systems offer remarkable examples of diverse structures (as well as building blocks) and processes resulting from self-assembly. The exploration of bioinspired assemblies not only allows for mimicking the structures of living systems, but it also leads to functions for applications in different fields that benefit humans. In the last several decades, efforts on understanding and controlling self-assembly of small molecules have produced a large library of candidates for developing the biomedical applications of assemblies of small molecules. Moreover, recent findings in biology have provided new insights on the assemblies of small molecules to modulate essential cellular processes (such as apoptosis). These observations indicate that the self-assembly of small molecules, as multifaceted entities and processes to interact with multiple proteins, can have profound biological impacts on cells. In this review, we illustrate that the generation of assemblies of small molecules in cell milieu with their interactions with multiple cellular proteins for regulating cellular processes can result in primary phenotypes, thus providing a fundamentally new molecular approach for controlling cell behavior. By discussing the correlation between molecular assemblies in nature and the assemblies of small molecules in cell milieu, illustrating the functions of the assemblies of small molecules, and summarizing some guiding principles, we hope this review will stimulate more molecular scientists to explore the bioinspired self-assembly of small molecules in cell milieu.

  7. Using Milieu Training to Promote Photograph Exchange for a Young Child with Autism

    ERIC Educational Resources Information Center

    Ogletree, Billy T.; Davis, Patricia; Hambrecht, Georgia; Phillips, Ellen Wooten

    2012-01-01

    A milieu teaching sequence was used to train photograph exchange as a method of requesting to a 7-year-old boy with autism. A multiple baseline design across four items (ball, puzzle, books, bubbles) was used to identify a functional relation between requesting and the milieu teaching sequence. Although performance during intervention was…

  8. Teaching Enhanced Milieu Language Teaching Skills to Parents in Multiple Risk Families

    ERIC Educational Resources Information Center

    Peterson, Pete; Carta, Judith J.; Greenwood, Charles

    2005-01-01

    A multiple baseline design across three parent-child dyads of families with multiple risk factors was used to determine the effectiveness of teaching parents to use milieu language teaching procedures. Parents were taught to use two sets of milieu language teaching skills: responsive interaction and incidental teaching. Results showed that parents…

  9. Psychodynamic Milieu-Therapy and Changes in Personality--What Is the Connection?

    ERIC Educational Resources Information Center

    Heede, Tine; Runge, Hanne; Storebo, Ole Jakob; Rowley, Eva; Hansen, Kim Gabriel

    2009-01-01

    This article refers to the results of a prospective effect evaluation study of three psychodynamic milieu-therapeutic institutions for children, which included cognitive and projective testing. After introducing milieu-therapy and explaining its roots in psychoanalytic and developmental thinking, the specific results of the research evaluation are…

  10. Milieu Therapy as a Communication Intervention: A Review of the Literature Related to Children with Autism Spectrum Disorder

    ERIC Educational Resources Information Center

    Mancil, G. Richmond

    2009-01-01

    Several researchers have employed milieu therapy to address the communication needs of children with autism spectrum disorder (ASD). Thus, the purpose of this review is to examine milieu therapy, particularly, the environments and individuals involved in the training and the effectiveness of milieu therapy with children who have a diagnosis of ASD…

  11. Les astronomes de l'Empire du Milieu

    NASA Astrophysics Data System (ADS)

    Bonnet-Bidaud, J. M.

    2007-02-01

    Explosions d'étoiles, comètes, durée du jour, taches solaires, dans tous ces domaines, des observations chinoises datant de plusieurs siècles sont encore utilisées aujourd'hui. Pendant plus de 4000 ans, les astronomes de l'Empire du Milieu, organisés dans les grands observatoires impériaux, ont noté jour après jour, mois après mois, avec la plus grande précision tous les phénomènes célestes. Et ce sont des milliers de textes couvrant des périodes depuis au moins le Ve siècle avant l'ère moderne jusqu'à fin de la dernière dynastie des Qing en 1911, qui ont été conservés et dont une grande partie n'a pu encore être véritablement étudiée. Un véritable trésor, malheureusement très mal connu en Europe et, de façon incompréhensible, largement ignoré par l'histoire moderne des sciences.

  12. Behavioral regulation of the milieu interne in man and rat.

    PubMed

    Garcia, J; Hankins, W G; Rusiniak, K W

    1974-09-06

    are critical in regulation of the internal milieu. When an animal is in need of calories, food tends to be more palatable; as the caloric deficit is restored, food becomes less palatable. If the animal's body temperature is below optimum, a warm stimulus applied to the skin is pleasant. When body temperature is too high, the converse is true. In this way, homeostatic states monitored by internal receptors produce changes in the incentive values of external stimuli sensed by the peripheral receptors, and guide feeding behavior. In mammals at least, the gustatory system, which provides sensory control of feeding, sends fibers to the nucleus solitarius. This brainstem relay station also receives fibers from the viscera and the internal monitors of the area postrema. Ascending fibers bifurcate at the level of the pons and project toward the feeding areas of the hypothalamus and the cortex. The olfactory system which primarily projects to the limbic system does not play a primary role in adjusting food incentives. Rather, it plays a secondary role in the activation of feeding, as do other external sensory systems. This specialized conditioning mechanism, which specifically adjusts gustatory hedonic values through delayed visceral feedback, is widespread among animals, including man and rat. These two species are remarkably similar in their thresholds and preferences for gustatory stimuli. The behavioral similarities are based on the animals' having similar gustatory systems, similar convergence of gustatory and internal afferents to the nucleus solitarius, and similar midbrain regulatory mechanisms. Thus, it is not surprising that the feeding of obese rats with internal hypothalamic damage resembles the feeding of obese human beings insensitive to the internal signs of this caloric state. Obviously, man has a highly specialized form of symbolic communication and the rat does not, yet man's cognitive specialization does not prevent him from developing aversions to food

  13. Dragons and Dinosaurs: Directing Inquiry in Biology Using the Notions of "Milieu" and "Validation"

    ERIC Educational Resources Information Center

    Achiam, Marianne; Solberg, Jan; Evans, Robert

    2013-01-01

    This article describes how inquiry teaching can be directed towards specific content learning goals while allowing for student exploration and validation of hypotheses. Drawing from the Theory of Didactical Situations, the concepts of "milieu" and "validation" are illustrated through two sample biology lessons designed to engage and challenge…

  14. Is More Better? Milieu Communication Teaching in Toddlers with Intellectual Disabilities

    ERIC Educational Resources Information Center

    Fey, Marc E.; Yoder, Paul J.; Warren, Steven F.; Bredin-Oja, Shelley L.

    2013-01-01

    Purpose: The authors sought to determine whether a program of 5 weekly doses of milieu communication teaching (MCT) would yield improvements in children's communication and word use compared with a once-weekly delivery of the same treatment. Method: Sixty-four children with intellectual and communication delay were randomly assigned to receive…

  15. Impact of Milieu Teaching on Communication Skills of Young Children with Autism Spectrum Disorder

    ERIC Educational Resources Information Center

    Christensen-Sandfort, Robyn J.; Whinnery, Stacie B.

    2013-01-01

    This 5-month study examined the impact of a behaviorally based naturalistic teaching strategy, milieu teaching, on the communication skills of preschool-aged children with Autism Spectrum Disorder (ASD) in an early childhood special education (ECSE) classroom. A multiple baseline across participants design was used. Communication targets were…

  16. Case Study: Parent-Implemented Prelinguistic Milieu Teaching with a High Risk Dyad

    ERIC Educational Resources Information Center

    McCathren, Rebecca B.

    2010-01-01

    The purpose of this study was twofold. The first purpose was to determine if a mother with mild developmental disabilities living in poverty was able to implement Prelinguistic Milieu Teaching (PMT) strategies. The strategies included following the child's lead, arranging the environment to increase opportunities for communication, imitating the…

  17. A Randomized Trial of Longitudinal Effects of Low-Intensity Responsivity Education/Prelinguistic Milieu Teaching

    ERIC Educational Resources Information Center

    Warren, Steven F.; Fey, Marc E.; Finestack, Lizbeth, H.; Brady, Nancy C.; Bredin-Oja, Shelley L.; Fleming, Kandace K.

    2008-01-01

    Purpose: To evaluate the longitudinal effects of a 6-month course of responsivity education (RE)/prelinguistic milieu teaching (PMT) for young children with developmental delay. Method: Fifty-one children, age 24-33 months, with fewer than 10 expressive words were randomly assigned to early-treatment/no-treatment groups. All treatment was added as…

  18. Parent-Implemented Enhanced Milieu Teaching with Preschool Children Who Have Intellectual Disabilities

    ERIC Educational Resources Information Center

    Kaiser, Ann P.; Roberts, Megan Y.

    2013-01-01

    Purpose: The purpose of this study was to compare the effects of enhanced milieu teaching (EMT) implemented by parents and therapists versus therapists only on the language skills of preschool children with intellectual disabilities (IDs), including children with Down syndrome and children with autism spectrum disorders. Method: Seventy-seven…

  19. Feeling “overloaded” and “shortcomings”: milieu therapists’ experiences of vulnerability in caring for severely mentally ill patients

    PubMed Central

    Bachmann, Liv; Michaelsen, Ragnhild A; Vatne, Solfrid

    2016-01-01

    Background Milieu therapists’ relationships with patients with severe mental illnesses are viewed as challenging. Elucidating vulnerability from their perspective in daily face-to-face encounters with patients might contribute to extending our knowledge about milieu therapists’ vulnerability and the dynamics of the interaction between patients in mental health services and expertise in building caring and therapeutic relationships. The aim of this project was to study educated milieu therapists’ experiences of their own vulnerability in their interactions with patients in mental health services. Materials and methods The data collection method was focus-group interviews. Thirteen part-time master’s in mental health students (eight nurses, three social workers, two social educators) participated. All participants had experience with community or specialized mental health services (2–8 years). Results The milieu therapists mainly related their experiences of vulnerability to negative feelings elicited by challenging work conditions, disclosed as two main themes: 1) “overloaded”, by the possibility of being physically and mentally hurt and the burdens of long-lasting close relationships; milieu therapists were extremely vulnerable because of their difficulty in protecting themselves; and 2) “shortcomings”, connected to feelings of despair associated with not acting in concordance with their professional standards and insecurity about their skills to handle challenging situations, which was a threat to their professional integrity. There seemed to be coherence between vulnerability and professional inauthenticity. A misunderstanding that professionalism refers to altruism seems to increase milieu therapist vulnerability. Conclusion Vulnerability in health care is of interest to multiple disciplines, and is of relevance for knowledge development in higher education. Extended knowledge and understanding about milieu therapists’ vulnerability might

  20. Social Milieu Oriented Routing: A New Dimension to Enhance Network Security in WSNs

    PubMed Central

    Liu, Lianggui; Chen, Li; Jia, Huiling

    2016-01-01

    In large-scale wireless sensor networks (WSNs), in order to enhance network security, it is crucial for a trustor node to perform social milieu oriented routing to a target a trustee node to carry out trust evaluation. This challenging social milieu oriented routing with more than one end-to-end Quality of Trust (QoT) constraint has proved to be NP-complete. Heuristic algorithms with polynomial and pseudo-polynomial-time complexities are often used to deal with this challenging problem. However, existing solutions cannot guarantee the efficiency of searching; that is, they can hardly avoid obtaining partial optimal solutions during a searching process. Quantum annealing (QA) uses delocalization and tunneling to avoid falling into local minima without sacrificing execution time. This has been proven a promising way to many optimization problems in recently published literatures. In this paper, for the first time, with the help of a novel approach, that is, configuration path-integral Monte Carlo (CPIMC) simulations, a QA-based optimal social trust path (QA_OSTP) selection algorithm is applied to the extraction of the optimal social trust path in large-scale WSNs. Extensive experiments have been conducted, and the experiment results demonstrate that QA_OSTP outperforms its heuristic opponents. PMID:26907277

  1. Social Milieu Oriented Routing: A New Dimension to Enhance Network Security in WSNs.

    PubMed

    Liu, Lianggui; Chen, Li; Jia, Huiling

    2016-02-19

    In large-scale wireless sensor networks (WSNs), in order to enhance network security, it is crucial for a trustor node to perform social milieu oriented routing to a target a trustee node to carry out trust evaluation. This challenging social milieu oriented routing with more than one end-to-end Quality of Trust (QoT) constraint has proved to be NP-complete. Heuristic algorithms with polynomial and pseudo-polynomial-time complexities are often used to deal with this challenging problem. However, existing solutions cannot guarantee the efficiency of searching; that is, they can hardly avoid obtaining partial optimal solutions during a searching process. Quantum annealing (QA) uses delocalization and tunneling to avoid falling into local minima without sacrificing execution time. This has been proven a promising way to many optimization problems in recently published literatures. In this paper, for the first time, with the help of a novel approach, that is, configuration path-integral Monte Carlo (CPIMC) simulations, a QA-based optimal social trust path (QA_OSTP) selection algorithm is applied to the extraction of the optimal social trust path in large-scale WSNs. Extensive experiments have been conducted, and the experiment results demonstrate that QA_OSTP outperforms its heuristic opponents.

  2. A Reducing Milieu Renders Cofilin Insensitive to Phosphatidylinositol 4,5-Bisphosphate (PIP2) Inhibition*

    PubMed Central

    Schulte, Bianca; John, Isabel; Simon, Bernd; Brockmann, Christoph; Oelmeier, Stefan A.; Jahraus, Beate; Kirchgessner, Henning; Riplinger, Selina; Carlomagno, Teresa; Wabnitz, Guido H.; Samstag, Yvonne

    2013-01-01

    Oxidative stress can lead to T cell hyporesponsiveness. A reducing micromilieu (e.g. provided by dendritic cells) can rescue T cells from such oxidant-induced dysfunction. However, the reducing effects on proteins leading to restored T cell activation remained unknown. One key molecule of T cell activation is the actin-remodeling protein cofilin, which is dephosphorylated on serine 3 upon T cell costimulation and has an essential role in formation of mature immune synapses between T cells and antigen-presenting cells. Cofilin is spatiotemporally regulated; at the plasma membrane, it can be inhibited by phosphatidylinositol 4,5-bisphosphate (PIP2). Here, we show by NMR spectroscopy that a reducing milieu led to structural changes in the cofilin molecule predominantly located on the protein surface. They overlapped with the PIP2- but not actin-binding sites. Accordingly, reduction of cofilin had no effect on F-actin binding and depolymerization and did not influence the cofilin phosphorylation state. However, it did prevent inhibition of cofilin activity through PIP2. Therefore, a reducing milieu may generate an additional pool of active cofilin at the plasma membrane. Consistently, in-flow microscopy revealed increased actin dynamics in the immune synapse of untransformed human T cells under reducing conditions. Altogether, we introduce a novel mechanism of redox regulation: reduction of the actin-remodeling protein cofilin renders it insensitive to PIP2 inhibition, resulting in enhanced actin dynamics. PMID:24003227

  3. Delusions and hallucinations as a reflection of the subcultural milieu among psychotic patients of the 1930s and 1980s.

    PubMed

    Mitchell, J; Vierkant, A D

    1989-05-01

    Delusions and hallucinations reported in the social histories of 150 patients admitted to an East Texas state hospital during the 1930s and of 150 patients admitted during the 1980s were examined for content that would characterize and contrast the patient subcultural milieu of the two time periods. Patients admitted during the 1930s tended to reflect the material deprivation and personal powerlessness of the great depression in delusions of great wealth and positive "special powers." The hallucinatory visions and voices of the 1980s patients reflected a more threatening and negative subcultural milieu, with more visions of blood, snakes, and dead people or animals. Command hallucinations to hurt, to kill, or to do "perverse things" would also suggest that the subculture milieu of the 1980s had become more dangerous.

  4. The mare as a model for luteinized unruptured follicle syndrome: intrafollicular endocrine milieu.

    PubMed

    Bashir, S T; Gastal, M O; Tazawa, S P; Tarso, S G S; Hales, D B; Cuervo-Arango, J; Baerwald, A R; Gastal, E L

    2016-03-01

    Luteinized unruptured follicle (LUF) syndrome is a recurrent anovulatory dysfunction that affects up to 23% of women with normal menstrual cycles and up to 73% with endometriosis. Mechanisms underlying the development of LUF syndrome in mares were studied to provide a potential model for human anovulation. The effect of extended increase in circulating LH achieved by administration of recombinant equine LH (reLH) or a short surge of LH and decrease in progesterone induced by prostaglandin F2α (PGF2α) on LUF formation (Experiment 1), identification of an optimal dose of COX-2 inhibitor (flunixin meglumine, FM; to block the effect of prostaglandins) for inducing LUFs (Experiment 2), and evaluation of intrafollicular endocrine milieu in LUFs (Experiment 3) were investigated. In Experiment 1, mares were treated with reLH from Day 7 to Day 15 (Day 0=ovulation), PGF2α on Day 7, or in combination. In Experiment 2, FM at doses of 2.0 or 3.0 mg/kg every 12 h and human chorionic gonadotropin (hCG) (1500 IU) were administered after a follicle ≥32 mm was detected. In Experiment 3, FM at a dose of 2.0 mg/kg every 12 h plus hCG was used to induce LUFs and investigate the intrafollicular endocrine milieu. No LUFs were induced by reLH or PGF2α treatment; however, LUFs were induced in 100% of mares using FM. Intrafollicular PGF2α metabolite, PGF2α, and PGE2 were lower and the ratio of PGE2:PGF2α was higher in the induced LUF group. Higher levels of intrafollicular E2 and total primary sex steroids were observed in the induced LUF group along with a tendency for higher levels of GH, cortisol, and T; however, LH, PRL, VEGF-A, and NO did not differ between groups. In conclusion, this study reveals part of the intrafollicular endocrine milieu and the association of prostaglandins in LUF formation, and indicates that the mare might be an appropriate model for studying the poorly understood LUF syndrome.

  5. The Milieu Intérieur study - an integrative approach for study of human immunological variance.

    PubMed

    Thomas, Stéphanie; Rouilly, Vincent; Patin, Etienne; Alanio, Cécile; Dubois, Annick; Delval, Cécile; Marquier, Louis-Guillaume; Fauchoux, Nicolas; Sayegrih, Seloua; Vray, Muriel; Duffy, Darragh; Quintana-Murci, Lluis; Albert, Matthew L

    2015-04-01

    The Milieu Intérieur Consortium has established a 1000-person healthy population-based study (stratified according to sex and age), creating an unparalleled opportunity for assessing the determinants of human immunologic variance. Herein, we define the criteria utilized for participant enrollment, and highlight the key data that were collected for correlative studies. In this report, we analyzed biological correlates of sex, age, smoking-habits, metabolic score and CMV infection. We characterized and identified unique risk factors among healthy donors, as compared to studies that have focused on the general population or disease cohorts. Finally, we highlight sex-bias in the thresholds used for metabolic score determination and recommend a deeper examination of current guidelines. In sum, our clinical design, standardized sample collection strategies, and epidemiological data analyses have established the foundation for defining variability within human immune responses.

  6. Neutrophils alter the inflammatory milieu by signal-dependent translation of constitutive messenger RNAs

    NASA Astrophysics Data System (ADS)

    Lindemann, Stephan W.; Yost, Christian C.; Denis, Melvin M.; McIntyre, Thomas M.; Weyrich, Andrew S.; Zimmerman, Guy A.

    2004-05-01

    The mechanisms by which neutrophils, key effector cells of the innate immune system, express new gene products in inflammation are largely uncharacterized. We found that they rapidly translate constitutive mRNAs when activated, a previously unrecognized response. One of the proteins synthesized without a requirement for transcription is the soluble IL-6 receptor , which translocates to endothelial cells and induces a temporal switch to mononuclear leukocyte recruitment. Its synthesis is regulated by a specialized translational control pathway that is inhibited by rapamycin, a bacterial macrolide with therapeutic efficacy in transplantation, inflammatory syndromes, and neoplasia. Signal-dependent translation in activated neutrophils may be a critical mechanism for alteration of the inflammatory milieu and a therapeutic target.

  7. The exercise-induced biochemical milieu enhances collagen content and tensile strength of engineered ligaments.

    PubMed

    West, Daniel W D; Lee-Barthel, Ann; McIntyre, Todd; Shamim, Baubak; Lee, Cassandra A; Baar, Keith

    2015-10-15

    Exercise stimulates a dramatic change in the concentration of circulating hormones, such as growth hormone (GH), but the biological functions of this response are unclear. Pharmacological GH administration stimulates collagen synthesis; however, whether the post-exercise systemic milieu has a similar action is unknown. We aimed to determine whether the collagen content and tensile strength of tissue-engineered ligaments is enhanced by serum obtained post-exercise. Primary cells from a human anterior cruciate ligament (ACL) were used to engineer ligament constructs in vitro. Blood obtained from 12 healthy young men 15 min after resistance exercise contained GH concentrations that were ∼7-fold greater than resting serum (P < 0.001), whereas IGF-1 was not elevated at this time point (P = 0.21 vs. rest). Ligament constructs were treated for 7 days with medium supplemented with serum obtained at rest (RestTx) or 15 min post-exercise (ExTx), before tensile testing and collagen content analysis. Compared with RestTx, ExTx enhanced collagen content (+19%; 181 ± 33 vs. 215 ± 40 μg per construct P = 0.001) and ligament mechanical properties - maximal tensile load (+17%, P = 0.03 vs. RestTx) and ultimate tensile strength (+10%, P = 0.15 vs. RestTx). In a separate set of engineered ligaments, recombinant IGF-1, but not GH, enhanced collagen content and mechanics. Bioassays in 2D culture revealed that acute treatment with post-exercise serum activated mTORC1 and ERK1/2. In conclusion, the post-exercise biochemical milieu, but not recombinant GH, enhances collagen content and tensile strength of engineered ligaments, in association with mTORC1 and ERK1/2 activation.

  8. Peculiarities of the Super-Folder GFP Folding in a Crowded Milieu

    PubMed Central

    Stepanenko, Olesya V.; Stepanenko, Olga V.; Kuznetsova, Irina M.; Uversky, Vladimir N.; Turoverov, Konstantin K.

    2016-01-01

    The natural cellular milieu is crowded by large quantities of various biological macromolecules. This complex environment is characterized by a limited amount of unoccupied space, limited amounts of free water, and changed solvent properties. Obviously, such a tightly packed cellular environment is poorly mimicked by traditional physiological conditions, where low concentrations of a protein of interest are analyzed in slightly salted aqueous solutions. An alternative is given by the use of a model crowded milieu, where a protein of interest is immersed in a solution containing high concentrations of various polymers that serve as model crowding agents. An expected outcome of the presence of such macromolecular crowding agents is their ability to increase conformational stability of a globular protein due to the excluded volume effects. In line with this hypothesis, the behavior of a query protein should be affected by the hydrodynamic size and concentration of an inert crowder (i.e., an agent that does not interact with the protein), whereas the chemical nature of a macromolecular crowder should not play a role in its ability to modulate conformational properties. In this study, the effects of different crowding agents (polyethylene glycols (PEGs) of various molecular masses (PEG-600, PEG-8000, and PEG-12000), Dextran-70, and Ficoll-70) on the spectral properties and unfolding–refolding processes of the super-folder green fluorescent protein (sfGFP) were investigated. sfGFP is differently affected by different crowders, suggesting that, in addition to the expected excluded volume effects, there are some changes in the solvent properties. PMID:27801849

  9. Epigenetic Modulation of Human Podocyte Vitamin D Receptor in HIV Milieu.

    PubMed

    Chandel, Nirupama; Ayasolla, Kameshwar S; Lan, Xiqian; Sultana-Syed, Maria; Chawla, Amrita; Lederman, Rivka; Vethantham, Vasupradha; Saleem, Moin A; Chander, Praveen N; Malhotra, Ashwani; Singhal, Pravin C

    2015-10-09

    HIV (human immunodeficiency virus) has been reported to induce podocyte injury through down regulation of vitamin D receptor (VDR) and activation of renin angiotensin system; however, the involved mechanism is not clear. Since HIV has been reported to modulate gene expression via epigenetic phenomena, we asked whether epigenetic factors contribute to down regulation of VDR. Kidney cells in HIV transgenic mice and HIV-infected podocytes (HIV/HPs) displayed enhanced expression of SNAIL, a repressor of VDR. To elucidate the mechanism, we studied the effect of HIV on expression of molecules involved in SNAIL repressor complex formation and demonstrated that HIV enhances expression of the histone deacetylase HDAC1 and DNA methyl transferases DNMT3b and DNMT1. 293T cells, when stably transfected with SNAIL (SNAIL/293T), displayed suppressed transcription and translation of VDR. In SNAIL/293T cells, co-immunoprecipitation studies revealed the association of HDAC1, DNMT3b, DNMT1, and mSin3A with SNAIL. Chromatin immunoprecipitation experiments confirmed the presence of the SNAIL repressor complex at the VDR promoter. Consistent with the enhanced DNA methyl transferase expression in HIV/HPs, there was an increased CpG methylation at the VDR promoter. Chromatin immunoprecipitation assay confirmed occurrence of H3K4 trimethylation on SNAIL promoter. Neither a VDR agonist (VDA) nor an HDAC inhibitor (HDACI) nor a demethylating agent (DAC) individually could optimally up regulate VDR in HIV milieu. However, VDA and HDACI when combined were successful in de-repressing VDR expression. Our findings demonstrate that SNAIL recruits multiple chromatin enzymes to form a repressor complex in HIV milieu that down regulates VDR expression.

  10. Non-targeted metabolomic evaluation of the uterine milieu during the transitional period of embryo elongation in the pig

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Alterations in the signaling of critical molecular factors within the uterine milieu lead to deficiencies in embryo elongation. The objective of this study was to identify metabolites within the uterine environment that are present as porcine embryos transition between spherical, ovoid, and tubular ...

  11. Effects of a Modified Milieu Therapy Intervention on the Social Communicative Behaviors of Young Children with Autism Spectrum Disorders

    ERIC Educational Resources Information Center

    Mancil, G. Richmond; Conroy, Maureen A.; Haydon, Todd F.

    2009-01-01

    The purpose of the current study was to evaluate the effectiveness of combining milieu therapy and functional communication training (FCT) to replace aberrant behavior with functional communicative skills in 3 male preschool or elementary aged children with Autism Spectrum Disorders (ASD). Study activities were conducted in the natural…

  12. A Comparative-Qualitative Research Analysis of Character Education in the Christian School and Home Education Milieu

    ERIC Educational Resources Information Center

    Wilhelm, Gretchen Marie

    2005-01-01

    This qualitative study provides a phenomenological perspective and comparative analysis of character education within the Christian school and home education milieu. The study is based on semi-structured interviews of fifty-two individuals (N = 52) representative of a sampling of Christian educators from four private, evangelical Christian Schools…

  13. Early Effects of Responsivity Education/Prelinguistic Milieu Teaching for Children with Developmental Delays and Their Parents

    ERIC Educational Resources Information Center

    Fey, Marc E.; Warren, Steven F.; Brady, Nancy; Finestack, Lizbeth H.; Bredin-Oja, Shelley L.; Fairchild, Martha; Sokol, Shari; Yoder, Paul J.

    2006-01-01

    Purpose: To evaluate the efficacy of a 6-month course of responsivity education/prelinguistic milieu teaching (RE/PMT) for children with developmental delay and RE/PMT's effects on parenting stress in a randomized clinical trial. Method: Fifty-one children, age 24-33 months, with no more than 10 expressive words or signs, were randomly assigned to…

  14. Self-assembled hydrogel fibers for sensing the multi-compartment intracellular milieu

    NASA Astrophysics Data System (ADS)

    Vemula, Praveen Kumar; Kohler, Jonathan E.; Blass, Amy; Williams, Miguel; Xu, Chenjie; Chen, Lynna; Jadhav, Swapnil R.; John, George; Soybel, David I.; Karp, Jeffrey M.

    2014-03-01

    Targeted delivery of drugs and sensors into cells is an attractive technology with both medical and scientific applications. Existing delivery vehicles are generally limited by the complexity of their design, dependence on active transport, and inability to function within cellular compartments. Here, we developed self-assembled nanofibrous hydrogel fibers using a biologically inert, low-molecular-weight amphiphile. Self-assembled nanofibrous hydrogels offer unique physical/mechanical properties and can easily be loaded with a diverse range of payloads. Unlike commercially available E. coli membrane particles covalently bound to the pH reporting dye pHrodo, pHrodo encapsulated in self-assembled hydrogel-fibers internalizes into macrophages at both physiologic (37°C) and sub-physiologic (4°C) temperatures through an energy-independent, passive process. Unlike dye alone or pHrodo complexed to E. coli, pHrodo-SAFs report pH in both the cytoplasm and phagosomes, as well the nucleus. This new class of materials should be useful for next-generation sensing of the intracellular milieu.

  15. Nutritional milieu of isolated stromal vascular cells determines their proliferative, adipogenic, and lipogenic capacity in vitro

    PubMed Central

    Kadegowda, Anil K G; Wright, Asher; Duckett, Susan K

    2014-01-01

    The objective was to determine the effect of nutritional milieu of isolated stromal vascular (SV) cells on proliferative capacity of preadipocytes, and adipogenic and lipogenic capacity in adipocytes in vitro. Proliferation of the preadipocytes increased over time with 48 and 72 h being greater than 24 h; however, preadipocytes from steers supplemented with corn (LC) had lower proliferation rates compared with those without corn grain supplementation (L) at 72 h. Adipocyte cultures isolated from LC group had higher mean diameter on d 4 and 6, and higher mean volume on d 0, 4, 6, and 12 of culture. Adipocytes from steers supplemented with corn grain (LC) had lower expression of key adipogenic genes during extended days in culture. The results show that prior nutritional treatment of the donor animal used to isolate SV cultures alters their proliferative, adipogenic, and lipogenic capacity in culture. These differences may be related to lower induction/expression of AP2 gene in the adipose cultures from corn supplemented group. Corn grain supplementation to steers grazing legumes could have stimulated more active adipogenic progenitor cells to differentiate, which would leave fewer behind in the SV pool for subsequent isolation. PMID:26317055

  16. Ecology and sampling techniques of an understudied subterranean habitat: the Milieu Souterrain Superficiel (MSS)

    NASA Astrophysics Data System (ADS)

    Mammola, Stefano; Giachino, Pier Mauro; Piano, Elena; Jones, Alexandra; Barberis, Marcel; Badino, Giovanni; Isaia, Marco

    2016-12-01

    The term Milieu Souterrain Superficiel (MSS) has been used since the early 1980s in subterranean biology to categorize an array of different hypogean habitats. In general terms, a MSS habitat represents the underground network of empty air-filled voids and cracks developing within multiple layers of rock fragments. Its origins can be diverse and is generally covered by topsoil. The MSS habitat is often connected both with the deep hypogean domain—caves and deep rock cracks—and the superficial soil horizon. A MSS is usually characterized by peculiar microclimatic conditions, and it can harbor specialized hypogean, endogean, and surface-dwelling species. In light of the many interpretations given by different authors, we reviewed 235 papers regarding the MSS in order to provide a state-of-the-art description of these habitats and facilitate their study. We have briefly described the different types of MSS mentioned in the scientific literature (alluvial, bedrock, colluvial, volcanic, and other types) and synthesized the advances in the study of the physical and ecological factors affecting this habitat—i.e., microclimate, energy flows, animal communities, and trophic interactions. We finally described and reviewed the available sampling methods used to investigate MSS fauna.

  17. Ecology and sampling techniques of an understudied subterranean habitat: the Milieu Souterrain Superficiel (MSS).

    PubMed

    Mammola, Stefano; Giachino, Pier Mauro; Piano, Elena; Jones, Alexandra; Barberis, Marcel; Badino, Giovanni; Isaia, Marco

    2016-12-01

    The term Milieu Souterrain Superficiel (MSS) has been used since the early 1980s in subterranean biology to categorize an array of different hypogean habitats. In general terms, a MSS habitat represents the underground network of empty air-filled voids and cracks developing within multiple layers of rock fragments. Its origins can be diverse and is generally covered by topsoil. The MSS habitat is often connected both with the deep hypogean domain-caves and deep rock cracks-and the superficial soil horizon. A MSS is usually characterized by peculiar microclimatic conditions, and it can harbor specialized hypogean, endogean, and surface-dwelling species. In light of the many interpretations given by different authors, we reviewed 235 papers regarding the MSS in order to provide a state-of-the-art description of these habitats and facilitate their study. We have briefly described the different types of MSS mentioned in the scientific literature (alluvial, bedrock, colluvial, volcanic, and other types) and synthesized the advances in the study of the physical and ecological factors affecting this habitat-i.e., microclimate, energy flows, animal communities, and trophic interactions. We finally described and reviewed the available sampling methods used to investigate MSS fauna.

  18. Self-assembled hydrogel fibers for sensing the multi-compartment intracellular milieu.

    PubMed

    Vemula, Praveen Kumar; Kohler, Jonathan E; Blass, Amy; Williams, Miguel; Xu, Chenjie; Chen, Lynna; Jadhav, Swapnil R; John, George; Soybel, David I; Karp, Jeffrey M

    2014-03-26

    Targeted delivery of drugs and sensors into cells is an attractive technology with both medical and scientific applications. Existing delivery vehicles are generally limited by the complexity of their design, dependence on active transport, and inability to function within cellular compartments. Here, we developed self-assembled nanofibrous hydrogel fibers using a biologically inert, low-molecular-weight amphiphile. Self-assembled nanofibrous hydrogels offer unique physical/mechanical properties and can easily be loaded with a diverse range of payloads. Unlike commercially available E. coli membrane particles covalently bound to the pH reporting dye pHrodo, pHrodo encapsulated in self-assembled hydrogel-fibers internalizes into macrophages at both physiologic (37°C) and sub-physiologic (4°C) temperatures through an energy-independent, passive process. Unlike dye alone or pHrodo complexed to E. coli, pHrodo-SAFs report pH in both the cytoplasm and phagosomes, as well the nucleus. This new class of materials should be useful for next-generation sensing of the intracellular milieu.

  19. Peri-Implantation Hormonal Milieu: Elucidating Mechanisms of Abnormal Placentation and Fetal Growth1

    PubMed Central

    Mainigi, Monica A.; Olalere, Devvora; Burd, Irina; Sapienza, Carmen; Bartolomei, Marisa; Coutifaris, Christos

    2013-01-01

    ABSTRACT Assisted reproductive technologies (ART) have been associated with several adverse perinatal outcomes involving placentation and fetal growth. It is critical to examine each intervention individually in order to assess its relationship to the described adverse perinatal outcomes. One intervention ubiquitously used in ART is superovulation with gonadotropins. Superovulation results in significant changes in the hormonal milieu, which persist during the peri-implantation and early placentation periods. Epidemiologic evidence suggests that the treatment-induced peri-implantation maternal environment plays a critical role in perinatal outcomes. In this study, using the mouse model, we have isolated the exposure to the peri-implantation period, and we examine the effect of superovulation on placentation and fetal growth. We report that the nonphysiologic peri-implantation maternal hormonal environment resulting from gonadotropin stimulation appears to have a direct effect on fetal growth, trophoblast differentiation, and gene expression. This appears to be mediated, at least in part, through trophoblast expansion and invasion. Although the specific molecular and cellular mechanism(s) leading to these observations remain to be elucidated, identifying this modifiable risk factor will not only allow us to improve perinatal outcomes with ART, but help us understand the pathophysiology contributing to these outcomes. PMID:24352558

  20. Coacervate whey protein improves inflammatory milieu in mice fed with high-fat diet

    PubMed Central

    2014-01-01

    Background Functional foods with bioactive properties may help in treat obesity, as they can lead to a decreased risks of inflammatory diseases. The aim of this study was to investigate the effects of chitosan coacervate whey protein on the proinflammatory processes in mice fed with high-fat diet. Methods Mice were divided into two groups receiving either a normolipidic or high-fat diet; the animals in each of the two diet groups were given a diet supplement of either coacervate (gavage, 36 mg protein/kg of body weight) or tap water for four weeks [groups: normolipidic diet plus water (C); normolipidic diet and coacervate (CC); high-fat diet and water (H); and high-fat diet and coacervate (HC)]. Results The high-fat diet promoted inflammation, possibly by decreased adiponectin/sum of adipose tissues ratio and increased phosphorylation of NF-κB p50. In HC we observed a positive correlation between IL-10 and TNF-α in mesenteric adipose tissue, retroperitoneal adipose tissue and liver tissue. We also observed a positive correlation between lipopolisaccharide with IL-10 in the liver tissue. Conclusions High-fat diet treatment promoted metabolic alterations and inflammation, and chitosan coacervate whey protein modulated inflammatory milieu. PMID:24673809

  1. Single yeast cell vacuolar milieu viscosity assessment by fluorescence polarization microscopy with computer image analysis.

    PubMed

    Puchkov, Evgeny O

    2012-05-01

    This study was undertaken to evaluate the apparent viscosity within the vacuoles of single Saccharomyces cerevisiae cells by steady-state fluorescence anisotropy measurements of quinacrine, using wide-field fluorescence polarization microscopy combined with computer image analysis. Quinacrine was shown to be rather specifically accumulated within the vacuoles of the cells. This accumulation was effectively reversed by ATP depletion of the cells, with no detectable binding of the dye within the vacuoles. Quinacrine fluorescence anisotropy in the sucrose solutions of various viscosities obeyed the Perrin equation. The fluorescence anisotropy of quinacrine was measured in the vacuoles of 39 cells. From cell to cell, this parameter changed in the range 0.032-0.086. Using the Perrin plot as a calibration curve, apparent viscosity values of the vacuolar milieu were calculated for each cell. The population of the cells studied was heterogeneous with regard to vacuolar viscosity, which was in the range 3.5 ± 0.4-14.06 ± 0.64 cP. There was a characteristic distribution of the frequencies of cells with apparent viscosities within certain limits, and cells with viscosity values in the range 5-6 cP were the most frequent. No relationship was found between the sizes of the vacuoles and their apparent viscosities.

  2. Cross-Milieu Terrorist Collaboration: Using Game Theory to Assess the Risk of a Novel Threat.

    PubMed

    Ackerman, Gary A; Zhuang, Jun; Weerasuriya, Sitara

    2017-02-01

    This article uses a game-theoretic approach to analyze the risk of cross-milieu terrorist collaboration-the possibility that, despite marked ideological differences, extremist groups from very different milieus might align to a degree where operational collaboration against Western societies becomes possible. Based upon theoretical insights drawn from a variety of literatures, a bargaining model is constructed that reflects the various benefits and costs for terrorists' collaboration across ideological milieus. Analyzed in both sequential and simultaneous decision-making contexts and through numerical simulations, the model confirms several theoretical arguments. The most important of these is that although likely to be quite rare, successful collaboration across terrorist milieus is indeed feasible in certain circumstances. The model also highlights several structural elements that might play a larger role than previously recognized in the collaboration decision, including that the prospect of nonmaterial gains (amplification of terror and reputational boost) plays at least as important a role in the decision to collaborate as potential increased capabilities does. Numerical simulation further suggests that prospects for successful collaboration over most scenarios (including operational) increase when a large, effective Islamist terrorist organization initiates collaboration with a smaller right-wing group, as compared with the other scenarios considered. Although the small number of historical cases precludes robust statistical validation, the simulation results are supported by existing empirical evidence of collaboration between Islamists and right- or left-wing extremists. The game-theoretic approach, therefore, provides guidance regarding the circumstances under which such an unholy alliance of violent actors is likely to succeed.

  3. Rocky milieu: Challenges of effective integration of clinical risk management into hospitals in Iran

    PubMed Central

    Farokhzadian, Jamileh; Nayeri, Nahid Dehghan; Borhani, Fariba

    2015-01-01

    Healthcare risks and clinical risks have been recognized as a major challenge in healthcare. Clinical risks can never be eliminated and can have serious adverse effects on patient safety. Thus, a clinical risk management (CRM) system has been introduced in the healthcare system to improve quality services. The aim of this study was to explore nurses’ experiences related to the challenges of implementing CRM in the organizational context. This qualitative study was based on the conventional content analysis of the Lundman and Graneheim approach, and it consisted of 22 interview sessions with 20 nurses. The purposive sampling method was used to choose the participants from three hospitals affiliated with the Kerman University of Medical Sciences. We used semi-structured interviews and review of relevant documents to collect data. The analysis of the data led to the emergence of “rocky milieu” as the main theme, and it consisted of three categories that, along with their subcategories, explain the challenges of implementing CRM. The three categories and their subcategories were (1) organizational culture and leadership challenges (decision and performance of leadership and cultural resistance to change), (2) limitation of resources (financial, human, and physical and equipment resources), and (3) variations and complexities in working conditions (the emotional, psychological, and social atmosphere and the heaviness of workload). Attempts have been made to establish CRM through clinical governance and accreditation, but organizational challenges have created a rocky milieu for implementing CRM. However, from an organizational context concerning the suitability of healthcare in Iran, there are obvious needs to move toward quality improvement and safe practices through the effective implementation of CRM. PMID:25968444

  4. Pituitary Adenlylate Cyclase Activating Peptide Protects Adult Neural Stem Cells from a Hypoglycaemic milieu

    PubMed Central

    Mansouri, Shiva; Lietzau, Grazyna; Lundberg, Mathias; Nathanson, David; Nyström, Thomas; Patrone, Cesare

    2016-01-01

    Hypoglycaemia is a common side-effect of glucose-lowering therapies for type-2 diabetic patients, which may cause cognitive/neurological impairment. Although the effects of hypoglycaemia in the brain have been extensively studied in neurons, how hypoglycaemia impacts the viability of adult neural stem cells (NSCs) has been poorly investigated. In addition, the cellular and molecular mechanisms of how hypoglycaemia regulates NSCs survival have not been characterized. Recent work others and us have shown that the pituitary adenylate cyclase-activating polypeptide (PACAP) and the glucagon-like peptide-1 receptor (GLP-1R) agonist Exendin-4 stimulate NSCs survival against glucolipoapoptosis. The aim of this study was to establish an in vitro system where to study the effects of hypoglycaemia on NSC survival. Furthermore, we determine the potential role of PACAP and Exendin-4 in counteracting the effect of hypoglycaemia. A hypoglycaemic in vitro milieu was mimicked by exposing subventricular zone-derived NSC to low levels of glucose. Moreover, we studied the potential involvement of apoptosis and endoplasmic reticulum stress by quantifying protein levels of Bcl-2, cleaved caspase-3 and mRNA levels of CHOP. We show that PACAP via PAC-1 receptor and PKA activation counteracts impaired NSC viability induced by hypoglycaemia. The protective effect induced by PACAP correlated with endoplasmic reticulum stress, Exendin-4 was ineffective. The results show that hypoglycaemia decreases NSC viability and that this effect can be substantially counteracted by PACAP via PAC-1 receptor activation. The data supports a potential therapeutic role of PAC-1 receptor agonists for the treatment of neurological complications, based on neurogenesis impairment by hypoglycaemia. PMID:27305000

  5. Exercise training can attenuate the inflammatory milieu in women with systemic lupus erythematosus.

    PubMed

    Perandini, Luiz A; Sales-de-Oliveira, Diego; Mello, Suzana B V; Camara, Niels O; Benatti, Fabiana B; Lima, Fernanda R; Borba, Eduardo; Bonfa, Eloisa; Sá-Pinto, Ana L; Roschel, Hamilton; Gualano, Bruno

    2014-09-15

    Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by chronic inflammation. This study sought to assess the effects of an exercise training program on cytokines and soluble TNF receptors (sTNFRs) in response to acute exercise in SLE women. Eight SLE women and 10 sex-, age-, and body mass index-comparable healthy controls (HC) participated in this study. Before and after a 12-wk aerobic exercise training program, cytokines and sTNFRs were assessed at rest and in response to single bouts of acute moderate/intense exercise. HC performed the acute exercise bouts only at baseline. After the exercise training program, there was a decrease in resting TNFR2 levels (P = 0.025) and a tend to reduction interleukin (IL)-10 levels (P = 0.093) in SLE. The resting levels of IL-6, IL-10, and TNF-α after the exercise training in SLE reached HC levels (P > 0.05). In response to a single bout of acute moderate exercise, the area under the curve (AUC) of IL-10 was significantly reduced after the exercise training program in SLE (P = 0.043), and the AUC of IL-10, IL-6, TNF-α, and sTNFR1 of SLE approached control values (P > 0.05). In response to a single bout of acute intense exercise, the AUC of IL-10 was significantly reduced in SLE (P = 0.015). Furthermore, the AUC of sTNFR2 tended to decrease after exercise training program in SLE (P = 0.084), but it did not reach control values (P = 0.001). An aerobic exercise training program attenuated the inflammatory milieu in SLE women, revealing a novel homeostatic immunomodulatory role of exercise in an autoimmunity condition.

  6. Release of hydrogen peroxide and antioxidants by the coral Stylophora pistillata to its external milieu

    NASA Astrophysics Data System (ADS)

    Armoza-Zvuloni, R.; Shaked, Y.

    2014-09-01

    Hydrogen peroxide (H2O2), a common reactive oxygen species, plays multiple roles in coral health and disease. Elevated H2O2 production by the symbiotic algae during stress may result in symbiosis breakdown and bleaching of the coral. We have recently reported that various Red Sea corals release H2O2 and antioxidants to their external milieu, and can influence the H2O2 dynamics in the reef. Here, we present a laboratory characterization of H2O2 and antioxidant activity release kinetics by intact, non-stressed Stylophora pistillata. Experimenting with bleached and non-bleached corals and different stirring speeds, we explored the sources and modes of H2O2 and antioxidant release. Since H2O2 is produced and degraded simultaneously, we developed a methodology for resolving the actual H2O2 concentrations released by the corals. H2O2 and antioxidant activity steadily increased in the water surrounding the coral over short periods of 1-2 h. Over longer periods of 5-7 h, the antioxidant activity kept increasing with time, while H2O2 concentrations were stabilized at ~ 1 μM by 1-3 h, and then gradually declined. Solving for H2O2 release, corals were found to release H2O2 at increasing rates over 2-4 h, and then to slow down and stop by 5-7 h. Stirring was shown to induce the release of H2O2, possibly since the flow reduces the thickness of the diffusive boundary layer of the coral, and thus increases H2O2 mass flux. Antioxidant activity was released at similar rates by bleached and non-bleached corals, suggesting that the antioxidants did not originate from the symbiotic algae. H2O2, however, was not released from bleached corals, implying that the symbiotic algae are the source of the released H2O2. The observed flow-induced H2O2 release may aid corals in removing some of the internal H2O2 produced by their symbiotic algae, and may possibly assist in preventing coral bleaching under conditions of elevated temperature and irradiance.

  7. Release of hydrogen peroxide and antioxidant by the coral Stylophora pistillata to its external milieu

    NASA Astrophysics Data System (ADS)

    Armoza-Zvuloni, R.; Shaked, Y.

    2014-01-01

    Hydrogen peroxide (H2O2), a common reactive oxygen species, plays multiple roles in coral health and disease. Elevated H2O2 production by the symbiotic algae during stress may result in symbiosis breakdown and bleaching of the coral. We have recently reported that various Red Sea corals release H2O2 and antioxidants to their external milieu and can influence the H2O2 dynamics in the reef. Here we present laboratory characterization of H2O2 and antioxidant activity release kinetics by intact, non-stressed Stylophora pistillata. Experimenting with bleached and non-bleached corals and different stirring speeds, we explored the sources and modes of H2O2 and antioxidant release. Since H2O2 is produced and degraded simultaneously, we developed methodology for resolving the actual rates of H2O2 release by the corals. H2O2 and antioxidant activity linearly increased in the water surrounding the coral over short periods of 1-2 h. Over longer periods of 5-7 h, the antioxidant activity kept increasing with time, while H2O2 concentrations were stabilized at ~ 1 μM by 2-3 h, and then gradually declined. Solving for H2O2 release, corals were found to release H2O2 at increasing rates over 2-4 h, and then slow down and stop by 5-7 h. Stirring was shown to induce the release of both H2O2 and antioxidant activity, possibly due to ventilation of the coral by the flow. Antioxidant activity was released at similar rates by bleached and non-bleached corals, suggesting that the antioxidant did not originate from the symbiotic algae. H2O2, however, was only minimally released from bleached corals, implying that the symbiotic algae are the source of the released H2O2. The observed flow-induced H2O2 release may aid corals in removing some of the internal H2O2 produced by their symbiotic algae and possibly assist in preventing coral bleaching under conditions of elevated temperature and irradiance.

  8. Les valvulopathies cardiaques en milieu hospitalier à Lomé (Togo)

    PubMed Central

    Balaka, Abago; Tchamdja, Toyi; Djibril, Mohaman Awalou; Djagadou, Kodjo Agbéko; Tchandana, Makilioubè; Damorou, Findibé; Agbétra, Aïssah

    2015-01-01

    Introduction Notre étude a consisté en l'identification les principales valvulopathies retrouvées en milieu hospitalier à Lomé (Togo). Méthodes Il s'agit d'une étude rétrospective, transversale, multicentrique menée du 1er janvier 2006 au 31 décembre 2010 et portant sur les dossiers de patients suivis dans le service de cardiologie du CHU Campus de Lomé. Résultats Du 1er janvier 2006 au 31 Décembre 2010,5412 patients ont été consulté dans le service de cardiologie du CHU Campus. Parmi eux, 241 (4,45%) présentaient une valvulopathie. On notait une prédominance féminine avec un sex-ratio H/F à 0,60. La moyenne d’âge était de 62,32 ans avec des extrêmes allant de 16 à 89 ans et un écart type de 14,27. Les antécédents le plus souvent retrouvés étaient l'hypertension artérielle (26,97%) et le diabète (8,29%). Parmi les motifs de consultations, les plus fréquents étaient la dyspnée (39,00%), les précordialgies (32,78%) et les palpitations (21,16%). A l'examen physique 30,70% des patients présentaient des signes de d'insuffisance cardiaque. A l’échographie, on notait des atteintes d'une seule valve (77,17%), de 02 valves (17,42%) ou 03 valves (5,4%). L'insuffisance mitrale (56,84%) et l'insuffisance aortique (30,70%) ont été les valvulopathies les plus fréquemment retrouvées. La maladie mitrale a été notée chez 05 patients. Les principales étiologies étaient dégénératives et ischémiques. Conclusion Les valvulopathies sont relativement fréquentes à Lomé. L'insuffisance cardiaque est leur principal mode de révélation. Les plus retrouvées sont l'insuffisance mitrale et aortique. PMID:26113911

  9. Intravitreal invading cells contribute to vitreal cytokine milieu in proliferative vitreoretinopathy

    PubMed Central

    El-Ghrably, I; Dua, H.; Orr, G.; Fischer, D.; Tighe, P.

    2001-01-01

    AIM—To examine the contribution of infiltrating cells in the local production of cytokines within the vitreous of patients with proliferative vitreoretinopathy (PVR).
METHODS—The presence of mRNA coding for IL-6, IL-8, IL-1β, IL-1α, TNFα, IFNγ, IL-12, and HPRT was investigated in 25 vitreous samples from patients with PVR, 11 vitreous samples from patients with retinal detachment (RD) not complicated by PVR, and 10 vitreous samples from patients with macular hole (MH). A quantitative reverse transcriptase polymerase chain reaction (RT-PCR) using an internal competitor was used to investigate these samples. From these samples, 15 PVR, 8 RD, and 8 MH were analysed for the protein levels of the same cytokines using enzyme linked immunosorbent assay (ELISA). Spearman correlation was used to test any association between mRNA and cytokine protein levels, as an indicator of the contribution these cells make to the intravitreal cytokine milieu.
RESULTS—A strong correlation was found between mRNA and their respective cytokine levels (protein products) for IL-6, IL-8, IL-1β, IL-1α, TNFα, IFNγ (Spearman r = 0.83, 0.73, 0.67, 0.91, 0.73, and 0.73 respectively), but not for IL-12. The median levels of IL-6, IL-8, IL-1β, and IFNγ mRNA and their respective cytokines were significantly higher (p <0.05) in patients with PVR than in those with macular hole. There was no statistically significant difference in the median levels of IL-1α mRNA between PVR and MH but the cytokine IL-1α was detected at a significantly higher level in PVR compared with MH patients. Between PVR and RD patients, there was no statistically significant difference in mRNA levels for all the investigated cytokines (p >0.05) except for IL-6 where there was a statistical significance (p= 0.038). In contrast, the median levels of IL-6, IL-8, and IL-1β cytokines were significantly higher (p <0.05) in patients with PVR than in those with RD, whereas for IL-1α and IFNγ no

  10. Short-Range Temporal Interactions in Sleep; Hippocampal Spike Avalanches Support a Large Milieu of Sequential Activity Including Replay.

    PubMed

    Mahoney, J Matthew; Titiz, Ali S; Hernan, Amanda E; Scott, Rod C

    2016-01-01

    Hippocampal neural systems consolidate multiple complex behaviors into memory. However, the temporal structure of neural firing supporting complex memory consolidation is unknown. Replay of hippocampal place cells during sleep supports the view that a simple repetitive behavior modifies sleep firing dynamics, but does not explain how multiple episodes could be integrated into associative networks for recollection during future cognition. Here we decode sequential firing structure within spike avalanches of all pyramidal cells recorded in sleeping rats after running in a circular track. We find that short sequences that combine into multiple long sequences capture the majority of the sequential structure during sleep, including replay of hippocampal place cells. The ensemble, however, is not optimized for maximally producing the behavior-enriched episode. Thus behavioral programming of sequential correlations occurs at the level of short-range interactions, not whole behavioral sequences and these short sequences are assembled into a large and complex milieu that could support complex memory consolidation.

  11. The cytokine milieu in the interplay of pathogenic Th1/Th17 cells and regulatory T cells in autoimmune disease

    PubMed Central

    Leung, Stewart; Liu, Xuebin; Fang, Lei; Chen, Xi; Guo, Taylor; Zhang, Jingwu

    2010-01-01

    The propagation and regulation of an immune response is driven by a network of effector and regulatory T (Treg) cells. The interplay of effector T and Treg cells determines the direction of the immune response towards inflammation or its resolution in an autoimmune disease setting. In autoimmune diseases, this interplay shifts the balance in favor of the development of autoreactive effector T cells, resulting in inflammatory pathology. The objective of an effective therapeutic approach for autoimmune disease is to restore this balance. In this review, we describe the characteristics and development of pathogenic T helper 1 (Th1) and Th17 cells and the beneficial Treg cells in autoimmune diseases and the crucial roles of the cytokine milieu in influencing the balance of these T-cell subsets. Given the importance of cytokines, we discuss current immunotherapeutic strategies using cytokine or cytokine receptor antibodies for the treatment of autoimmune diseases. PMID:20383174

  12. A Comparison of High and Low Dosages of a Component of Milieu Teaching Strategies for Two Preschool-Age Learners with Autism Spectrum Disorder

    ERIC Educational Resources Information Center

    Julien, Hannah M.; Reichle, Joe

    2016-01-01

    Purpose: The intersection of treatment intensity and communication intervention is an emerging area of investigation. Milieu teaching (MT) approaches for teaching communication skills to children with autism spectrum disorder (ASD) have a substantial evidence base (see Goldstein, 2002). However, a relatively small percentage (37.8%) of MT studies…

  13. Inwardly rectifying K+ (Kir) channels in Drosophila. A crucial role of cellular milieu factors Kir channel function.

    PubMed

    Döring, Frank; Wischmeyer, Erhard; Kühnlein, Ronald P; Jäckle, Herbert; Karschin, Andreas

    2002-07-12

    Three cDNAs encoding inwardly rectifying potassium (Kir) channels were isolated from Drosophila melanogaster. The protein sequences of Drosophila KirI (dKirI) and dKirII are moderately (<44%) and dKirIII sequence is weakly (<27%) identical to human Kir channel subunits. During fly development, five dKir channel transcripts derived from three genes are differentially expressed. Whole mount in situ hybridizations revealed dKirI transcripts absent from embryos, but dKirII and dKirIII are expressed in the embryonic hind gut and in Malpighian tubules, respectively, thus covering the entire osmoregulatory system of the developing fly. In the head of adult flies, predominantly dKirII transcripts were detected. When expressed in Xenopus oocytes, dKir channel activity was only observed after amino acid substitutions in their cytosolic tails (e.g. exchange of a unique valine in the NH(2) terminus). In contrast, heterologous expression of wild type dKirI and dKirII in Drosophila S2 cells readily evoked typical inwardly rectifying K(+) currents, which were weakly sensitive to Ba(2+). Thus, the specific milieu of insect cells provides a crucial cellular environment for proper function of dKir channels.

  14. The acidic milieu of the horny layer: new findings on the physiology and pathophysiology of skin pH.

    PubMed

    Rippke, Frank; Schreiner, Volker; Schwanitz, Hans-Joachim

    2002-01-01

    The acidic pH of the horny layer, measurable on the skin surface, has long been regarded as a result of exocrine secretion of the skin glands. The 'acid mantle' was thought to regulate the bacterial skin flora and to be sensitive primarily to skin cleansing procedures. In recent years, an increasing number of investigations have been published on the changes in, and constituents and functions of, the pH of the deeper layers of the stratum corneum, as well as on the influence of physiological and pathological factors. A central role for the acidic milieu as a regulating factor in stratum corneum homeostasis is now emerging. This has relevance to the integrity of the barrier function, from normal maturation of the stratum corneum lipids through to desquamation. Changes in the pH and the organic factors influencing it appear to play a role, not only in the pathogenesis, prevention and treatment of irritant contact dermatitis, but also of atopic dermatitis and ichthyosis and in wound healing. On the basis of these findings, a broader concept, exceeding the superficial 'acid mantle' theory, has been formulated.

  15. Cross-talk among myeloid-derived suppressor cells, macrophages, and tumor cells impacts the inflammatory milieu of solid tumors

    PubMed Central

    Beury, Daniel W.; Parker, Katherine H.; Nyandjo, Maeva; Sinha, Pratima; Carter, Kayla A.; Ostrand-Rosenberg, Suzanne

    2014-01-01

    MDSC and macrophages are present in most solid tumors and are important drivers of immune suppression and inflammation. It is established that cross-talk between MDSC and macrophages impacts anti-tumor immunity; however, interactions between tumor cells and MDSC or macrophages are less well studied. To examine potential interactions between these cells, we studied the impact of MDSC, macrophages, and four murine tumor cell lines on each other, both in vitro and in vivo. We focused on IL-6, IL-10, IL-12, TNF-α, and NO, as these molecules are produced by macrophages, MDSC, and many tumor cells; are present in most solid tumors; and regulate inflammation. In vitro studies demonstrated that MDSC-produced IL-10 decreased macrophage IL-6 and TNF-α and increased NO. IL-6 indirectly regulated MDSC IL-10. Tumor cells increased MDSC IL-6 and vice versa. Tumor cells also increased macrophage IL-6 and NO and decreased macrophage TNF-α. Tumor cell-driven macrophage IL-6 was reduced by MDSC, and tumor cells and MDSC enhanced macrophage NO. In vivo analysis of solid tumors identified IL-6 and IL-10 as the dominant cytokines and demonstrated that these molecules were produced predominantly by stromal cells. These results suggest that inflammation within solid tumors is regulated by the ratio of tumor cells to MDSC and macrophages and that interactions of these cells have the potential to alter significantly the inflammatory milieu within the tumor microenvironment. PMID:25170116

  16. Franchissement du seuil dans un laser monomode à milieu actif homogène : étude spectrale auto-cohérente

    NASA Astrophysics Data System (ADS)

    Boucher, Y. G.

    2006-10-01

    Nous présentons une étude auto-cohérente du franchissement du seuil dans un laser monomode à milieu actif homogène. Nous obtenons pour la puissance, la longueur d'onde et la largeur de raie des expressions universelles en coordonnées normalisées, continûment valables de part et d'autre du seuil.

  17. Light/Dark Shifting Promotes Alcohol-Induced Colon Carcinogenesis: Possible Role of Intestinal Inflammatory Milieu and Microbiota

    PubMed Central

    Bishehsari, Faraz; Saadalla, Abdulrahman; Khazaie, Khashayarsha; Engen, Phillip A.; Voigt, Robin M.; Shetuni, Brandon B.; Forsyth, Christopher; Shaikh, Maliha; Vitaterna, Martha Hotz; Turek, Fred; Keshavarzian, Ali

    2016-01-01

    Background: Colorectal cancer (CRC) is associated with the modern lifestyle. Chronic alcohol consumption—a frequent habit of majority of modern societies—increases the risk of CRC. Our group showed that chronic alcohol consumption increases polyposis in a mouse mode of CRC. Here we assess the effect of circadian disruption—another modern life style habit—in promoting alcohol-associated CRC. Method: TS4Cre × adenomatous polyposis coli (APC)lox468 mice underwent (a) an alcohol-containing diet while maintained on a normal 12 h light:12 h dark cycle; or (b) an alcohol-containing diet in conjunction with circadian disruption by once-weekly 12 h phase reversals of the light:dark (LD) cycle. Mice were sacrificed after eight weeks of full alcohol and/or LD shift to collect intestine samples. Tumor number, size, and histologic grades were compared between animal groups. Mast cell protease 2 (MCP2) and 6 (MCP6) histology score were analyzed and compared. Stool collected at baseline and after four weeks of experimental manipulations was used for microbiota analysis. Results: The combination of alcohol and LD shifting accelerated intestinal polyposis, with a significant increase in polyp size, and caused advanced neoplasia. Consistent with a pathogenic role of stromal tryptase-positive mast cells in colon carcinogenesis, the ratio of mMCP6 (stromal)/mMCP2 (intraepithelial) mast cells increased upon LD shifting. Baseline microbiota was similar between groups, and experimental manipulations resulted in a significant difference in the microbiota composition between groups. Conclusions: Circadian disruption by Light:dark shifting exacerbates alcohol-induced polyposis and CRC. Effect of circadian disruption could, at least partly, be mediated by promoting a pro-tumorigenic inflammatory milieu via changes in microbiota. PMID:27918452

  18. Key endothelial cell angiogenic mechanisms are stimulated by the circulating milieu in sickle cell disease and attenuated by hydroxyurea.

    PubMed

    Lopes, Flavia C M; Traina, Fabiola; Almeida, Camila B; Leonardo, Flavia C; Franco-Penteado, Carla F; Garrido, Vanessa T; Colella, Marina P; Soares, Raquel; Olalla-Saad, Sara T; Costa, Fernando F; Conran, Nicola

    2015-06-01

    As hypoxia-induced inflammatory angiogenesis may contribute to the manifestations of sickle cell disease, we compared the angiogenic molecular profiles of plasma from sickle cell disease individuals and correlated these with in vitro endothelial cell-mediated angiogenesis-stimulating activity and in vivo neovascularization. Bioplex demonstrated that plasma from patients with steady-state sickle cell anemia contained elevated concentrations of pro-angiogenic factors (angiopoietin-1, basic fibroblast growth factor, vascular endothelial growth factor, vascular endothelial growth factor-D and placental growth factor) and displayed potent pro-angiogenic activity, significantly increasing endothelial cell proliferation, migration and capillary-like structure formation. In vivo neovascularization of Matrigel plugs was significantly greater in sickle cell disease mice than in non-sickle cell disease mice, consistent with an up-regulation of angiogenesis in the disease. In plasma from patients with hemoglobin SC disease without proliferative retinopathy, anti-angiogenic endostatin and thrombospondin-2 were significantly elevated. In contrast, plasma from hemoglobin SC individuals with proliferative retinopathy had a pro-angiogenic profile and more significant effects on endothelial cell proliferation and capillary formation than plasma from patients without retinopathy. Hydroxyurea therapy was associated with significant reductions in plasma angiogenic factors and inhibition of endothelial cell-mediated angiogenic mechanisms and neovascularization. Thus, individuals with sickle cell anemia or hemoglobin SC disease with retinopathy present a highly angiogenic circulating milieu, capable of stimulating key endothelial cell-mediated angiogenic mechanisms. Combination anti-angiogenic therapy to prevent the progression of unregulated neovascularization and associated manifestations in sickle cell disease, such as pulmonary hypertension, may be indicated; furthermore, the

  19. [Encouraging healthy habits by playing with the child in the family milieu: the snakes and ladders game].

    PubMed

    Sánchez Echenique, M; Pèlach, R

    2002-01-01

    In recent decades society has been undergoing many changes and these have had a strong incidence on infant morbidity and mortality. Diseases that have practically vanished due to the impact of vaccinations and the improvement of the standard of living have given way to others derived from the changes in eating habits and life style; accidents, on the other hand, have come to be the first cause of morbidity and mortality after the first year of life has been passed. Strategies must be directed towards avoiding the causes of this new way of falling ill. We present a Spanish version of a game similar to "snakes and ladders" called "the healthy goose", which encourages healthy living habits. In order that the child should internalize safe habits by means of the game, certain squares in the game have been replaced by positive drawings, in which the child carries out healthy activities, receiving prizes for these, and others in which risky activities are performed, which are penalized. The areas dealt with are: habits (nutrition, sleep, study, games, etc.), Accidents at home, road safety (pedestrian, cyclist and automobile traveler), and swimming pools. The game starts with a child of 3-4 years and the goal is reached as a healthy adolescent. Given that the variation in personalities is enormous, we believe the family milieu should be the complement to legislative and educational measures and general campaigns in the means of communication, since it is what the child knows best and where he learns his deepest attitudes. This game could be a help to parents in this difficult task.

  20. Modelisation du Signal Radar EN Milieu Stratifie et Evaluation de Techniques de Mesure de L'humidite du Sol

    NASA Astrophysics Data System (ADS)

    Boisvert, Johanne

    La presente etude se penche sur des problemes relies a l'echantillonnage de l'humidite de sol et a l'estimation du signal radar sur sols nus. Le travail se divise en deux volets. Le volet 1 evalue trois techniques de mesure de l'humidite du sol (gravimetrie, reflectometrie temporelle et sonde dielectrique) et deux protocoles d'echantillonnage. Dans le volet 2, un modele de simulation du signal en milieu stratifie est developpe, et les estimes de signal obtenus sont compares aux estimes bases uniquement sur une valeur moyenne d'humidite du sol prise sur une profondeur fixe d'echantillonnage. Les differences entre les deux estimes dependent de la frequence et du choix judicieux de la profondeur d'echantillonnage; elles sont plus importantes aux faibles angles et en polarisation HV, puis VV. Le modele de simulation a aussi ete utilise pour etudier la profondeur de penetration du signal et en deduire la profondeur optimale d'echantillonnage en tenant compte des caracteristiques du signal. Une variation de 25 ^circ de l'angle d'incidence a peu d'effet sur la profondeur de penetration en bande Ku; l'ecart reste inferieur ou egal a 0,5 cm en bande C mais peut atteindre 1,3 cm en bande L. L'impact de la polarisation est nul en bande Ku mais croi t avec l'angle d'incidence en bande C et L. A 50^circ, il est, en moyenne de 1 cm en bande C et de 2 cm en bande L. En polarisation VV, la profondeur croi t avec une augmentation de l'angle alors que l'effet est inverse en polarisation HH. Deux methodes pour estimer la profondeur d'echantillonnage en conditions operationnelles sont presentees. Lorsqu'on inverse un modele pour estimer l'humidite du sol a partir du signal, ces methodes permettent aussi d'estimer l'epaisseur de sol representee par l'humidite ainsi estimee.

  1. Les tumeurs malignes anorectales en milieu hospitalier à Ouagadougou: aspects épidémiologiques et diagnostiques

    PubMed Central

    Guingané, Alice Nanelin; Sombié, Roger Arsène; Bougouma, Alain

    2014-01-01

    Le but de notre étude était de décrire les caractéristiques épidémiologiques et diagnostiques des tumeurs malignes anorectales en milieu hospitalier à Ouagadougou. Il s'est agi d'une étude rétrospective et transversale qui a concerné les patients vus en endoscopie digestive basse au cours de la période allant du 29/09/1999 au 04/10/2008. À l'aide d'une fiche de collecte, nous avons recueilli, dans 4 structures sanitaires et 3 laboratoires d'anatomie et de cytologie pathologiques de la ville de Ouagadougou, les données à partir des comptes-rendus d'endoscopie digestive basse et des registres d'anatomie et de cytologie pathologiques. Durant la période de notre étude, 645 patients ont été examinés en anorectoscopie et 882 cas d'affections anorectales colligés. Les tumeurs malignes anorectales avec 61 cas (6,9%) occupaient la quatrième place après la maladie hémorroïdaire (45,6%), les anites (21,1%) et les fissures (13,9%). Elles regroupaient les cancers du rectum (4,2%) et les cancers de l'anus (2,7%). Vingt cancers anorectaux ont été histologiquement confirmés parmi lesquels l'adénocarcinome était le type histologique le plus retrouvé avec 17 cas. Les tumeurs malignes, quatrième affection anorectale la plus fréquente au cours de notre étude, constituent une préoccupation du fait de leur fréquence croissante, leur diagnostic souvent tardif et les difficultés liées à leur prise en charge surtout dans nos pays avec une population à faible revenu. La sensibilisation de la population et la prescription plus large de l'endoscopie digestive basse devraient permettre une meilleure prise en charge des patients. PMID:25368715

  2. [Cosmos, coral and cultural milieu. The significance of the popular science connection in the late German Empire and the Weimar Republic].

    PubMed

    Schirrmacher, Arne

    2008-12-01

    This paper discusses the role of popular science communication for the 'cultural milieu' or more generally the 'environment' of scientists and science in Germany between c. 1900 and 1933 in the sense of Paul Forman. On the rich basis of diverse journals aiming at a differentiated public the discourse on atomic physics is sketched. Since the thesis of a general hostility towards atomic physics in particular and science in general cannot be accredited the question arises how widespread and in which sense a crisis of science was discussed in the Weimar years.

  3. A Zn2+ specific triazole based calix[4]arene conjugate (L) as a fluorescence sensor for histidine and cysteine in HEPES buffer milieu.

    PubMed

    Pathak, Rakesh Kumar; Tabbasum, Khatija; Rai, Ankit; Panda, Dulal; Rao, Chebrolu Pulla

    2012-09-07

    A highly fluorescent Zn(2+) complex of the triazole linked salicyl-imino-thiophenyl conjugate of calix[4]arene, [ZnL] has been demonstrated to be a chemo-sensing ensemble for the recognition of His and Cys among the naturally occurring amino acids in HEPES buffer milieu. The recognition behaviour of the [ZnL] towards these amino acids has been shown on the basis of fluorescence, absorption and visual fluorescent colour changes. The species of recognition were shown by ESI MS titrations, AFM & TEM microscopy and cell studies.

  4. Approche aux soins en milieu communautaire à des adultes ayant une déficience développementale

    PubMed Central

    Osmun, W.E.; Chan, Nelson; Solomon, Robert

    2015-01-01

    Résumé Objectif Passer en revue les obligations d’ordre médical, éthique et juridique dans les soins aux adultes ayant une déficience développementale (DD) qui vivent dans la communauté. Sources des données Des recherches ont été faites dans Google et MEDLINE à l’aide des mots disabled, disability, vulnerable et community. Les lois pertinentes ont fait l’objet d’un examen. Message principal Le traitement d’un patient ayant une DD varie en fonction de facteurs comme la pathogenèse du problème actuel du patient, ses affections concomitantes, la gravité de ses déficiences et ses soutiens sociaux habituels. Bien que l’on s’entende sur les bienfaits du transfert des soins institutionnels vers des soins communautaires pour les patients ayant une DD, il s’est révélé difficile de leur dispenser des soins de grande qualité en milieu communautaire. Par ailleurs, il existe peu de travaux de recherche sur les façons d’offrir efficacement des soins aux adultes ayant une DD. En tant que professionnels des soins primaires, les médecins de famille sont souvent le premier point de contact pour les patients et sont à la fois responsables de la coordination et de la continuité des soins. Compte tenu de l’importance accrue accordée aux soins préventifs et à la détection précoce des maladies, la participation active du patient revêt aussi une grande importance. Les valeurs et les objectifs du patient sont des éléments essentiels à prendre en compte, même s’ils vont à l’encontre de la bonne santé du patient ou des propres valeurs du clinicien. Les lois s’appliquant aux personnes vulnérables varient d’une province à l’autre. Par conséquent, l’obligation de signaler des mauvais traitements suspectés pourrait différer selon que la personne vulnérable habite dans un centre de soins ou la communauté, que la personne qui soupçonne le comportement abusif est un fournisseur de services ou un professionnel de la santé ou

  5. Considerations for Defining Cytokine Dose, Duration, and Milieu That Are Appropriate for Modeling Chronic Low-Grade Inflammation in Type 2 Diabetes

    PubMed Central

    2016-01-01

    Proinflammatory cytokines have been implicated in the pathophysiology of both type 1 diabetes (T1D) and type 2 diabetes (T2D). T1D is an autoimmune disease involving the adaptive immune system responding to pancreatic beta-cells as antigen-presenting cells. This attracts immune cells that surround pancreatic islets (insulitis) and secrete cytokines, such as IL-1beta, IFN-gamma, and TNF-alpha, in close proximity to pancreatic beta-cells. In contrast, there is little evidence for such a focused autoimmune response in T2D. Instead, the innate immune system, which responds to cellular damage and pathogens, appears to play a key role. There are three major sources of proinflammatory cytokines that may impact islet/beta-cell function in T2D: (1) from islet cells, (2) from increased numbers of intraislet macrophages/immune cells, and (3) from increased circulating levels of proinflammatory cytokines due to obesity, presumably coming from inflamed adipose tissue. These differences between T1D and T2D are reflected by significant differences in the cytokine concentration, duration, and milieu. This review focuses on chronic versus acute cytokine action, cytokine concentrations, and cytokine milieu from the perspective of the pancreatic islet in T2D. We conclude that new cytokine models may be needed to reflect the pathophysiology of T2D more effectively than what are currently employed. PMID:27843953

  6. Defected red blood cell membranes and direct correlation with the uraemic milieu: the connection with the decreased red blood cell lifespan observed in haemodialysis patients

    NASA Astrophysics Data System (ADS)

    Stamopoulos, D.; Grapsa, E.; Manios, E.; Gogola, V.; Bakirtzi, N.

    2012-12-01

    Together with impaired production of erythropoietin and iron deficiency, the decreased lifespan of red blood cells (RBCs) is a main factor contributing to the chronic anaemia observed in haemodialysis (HD) patients. Atomic force microscopy is employed in this work to thoroughly survey the membrane of intact RBCs (iRBCs) of HD patients in comparison to those of healthy donors, aiming to obtain direct information on the structural status of RBCs that can be related to their decreased lifespan. We observed that the iRBC membrane of the HD patients is overpopulated with extended circular defects, termed ‘orifices’, that have typical dimension ranging between 0.2 and 1.0 μm. The ‘orifice’ index—that is, the mean population of ‘orifices’ per top membrane surface—exhibits a pronounced relative increase of order 54 ± 12% for the HD patients as compared to healthy donors. Interestingly, for the HD patients, the ‘orifice’ index, which relates to the structural status of the RBC membrane, correlates strongly with urea concentration, which is a basic index of the uraemic milieu. Thus, these results indicate that the uraemic milieu downgrades the structural status of the RBC membrane, possibly triggering biochemical processes that result in their premature elimination from the circulation. This process could decrease the lifespan of RBCs, as observed in HD patients.

  7. Électropolymérisation de l'aniline en milieu neutre : application au dépôt de polyaniline sur acier doux

    NASA Astrophysics Data System (ADS)

    Camalet, J. L.; Lacroix, J. C.; Aeiyach, S.; Lacaze, P. C.

    1998-06-01

    The use of perchlorate ions allowed to carry out the aniline electropolymerization on Pt and mild steel in neutral aqueous medium and yield conducting, homogenoeus and adhering polyaniline films. Their structure, studied by IR, SEC and MS-MALDI, was characterized by a low degree of polymerization (DP ≈ 9) and a linear structure with chain coupling in 1,4 position of aniline rings. L'utilisation de l'ion perchlorate permet de réaliser l'électropolymé risation de l'aniline sur électrode de Pt et d'acier doux en milieu aqueux neutre (pH = 7). Des films conducteurs, homogènes et adhérents aux substrats sont obtenus. L'analyse par IR, CES et MS-MALDI, révèle un faible degré de polymérisation (DP ≈ 9) et des couplages essentiellement 1-4 des noyaux aromatiques.

  8. A Qualitative Analysis of Substance Use among Liberian Youth: Understanding Behaviors, Consequences, and Protective Factors Involving School Youth and the School Milieu

    PubMed Central

    Pullen, Samuel J; Petruzzi, Liana; Lange, Brittany CL; Parnarouskis, Lindsey; Dominguez, Silvia; Harris, Benjamin; Quiterio, Nicole; Durham, Michelle P; Lekpeh, Gondah; Manobah, Burgess; Slopadoe, Siede P; Diandy, Veronique C; Payne, Arthur J; Henderson, David C; Borba, Christina PC

    2016-01-01

    Objective Substance use is a significant and common problem among school-aged youths throughout Africa. Like other countries on this continent, the West-African nation of Liberia is recovering from civil war. A well-educated population of young people is critical to the recovery efforts and long-term success of Liberia. Substance use by school-aged youths has important public health consequences that could undermine Liberia’s post-conflict recovery efforts. We wanted to better understand the culturally significant themes and subthemes related to substance use among youths attending public schools in Monrovia, Liberia. Methods A qualitative research design was used to collect data from 72 students attending public school in Monrovia, Liberia. Nine focus groups of 6–8 students from three public schools were facilitated using a semi-structured format to guide discussions on substance use. Student narratives were translated and re-occurring themes and subthemes were coded and analyzed. Results Four emergent themes described in this study were: Behaviors associated with substance use Consequences associated with individual use Consequences of substance use that affected the school milieu School-related factors that were protective from substance use. Subthemes associated with substance use included concealment of substances, intoxication and disruption of the classroom environment, expulsion from school, school drop-out, and school as protective against substance use. Conclusion Liberian school-aged youths described important themes and subthemes associated with substance use occurring within the school milieu. These data have germane public health ramifications, and could help inform larger epidemiologic study methods and public health interventions for Liberia and countries with similar profiles. PMID:27158680

  9. MMP1-1607 polymorphism increases the risk for periapical lesion development through the upregulation MMP-1 expression in association with pro-inflammatory milieu elements

    PubMed Central

    TROMBONE, Ana Paula Favaro; CAVALLA, Franco; SILVEIRA, Elcia Maria Varize; ANDREO, Camile Bermejo; FRANCISCONI, Carolina Favaro; FONSECA, Angélica Cristina; LETRA, Ariadne; SILVA, Renato Menezes; GARLET, Gustavo Pompermaier

    2016-01-01

    ABSTRACT Increased matrix metalloproteinases (MMPs) activity is a hallmark of periapical granulomas. However, the factors underlying the MMPs expression modulation in healthy and diseased periapical tissues remains to be determined. Objective In this study, we evaluated the association between the MMP1-1607 polymorphism (rs1799750) and pro-inflammatory milieu elements with MMP-1 mRNA levels in vivo. Material and Methods MMP1-1607 SNP and the mRNA levels of MMP-1, TNF-a, IFN-g, IL-17A, IL-21, IL-10, IL-4, IL-9, and FOXp3 were determined via RealTimePCR in DNA/RNA samples from patients presenting periapical granulomas (N=111, for both genotyping and expression analysis) and control subjects (N=214 for genotyping and N=26 for expression analysis). The Shapiro-Wilk, Fisher, Pearson, Chi-square ordinal least squares regression tests were used for data analysis (p<0.05 was considered statistically significant). Results The MMP1-1607 1G/2G and 1G/2G+2G/2G genotypes were significantly more prevalent in the patients than in controls, comprising a risk factor for periapical lesions development. MMP-1 mRNA levels were higher in periapical lesions than in healthy periodontal ligament samples, as well as higher in active than in inactive lesions. The polymorphic allele 2G carriers presented a significantly higher MMP-1 mRNA expression when compared with the 1G/1G genotype group. The ordered logistic regression demonstrated a significant correlation between the genetic polymorphism and the expression levels of MMP-1. Additionally, the pro- and anti-inflammatory cytokines IL-17A, IFN-g, TNF-a, IL-21, IL-10, IL-9, and IL-4 were significant as complementary explanatory variables of MMP-1 expression. Conclusion The MMP1-1607 SNP was identified as a risk factor for periapical lesions development, possibly due to its association with increased MMP-1 mRNA levels in periapical lesions. The MMP-1 expression is also under the control of the inflammatory milieu elements, being the

  10. Prévalence des cervicalgies et douleurs des membres supérieures chez les utilisateurs d'ordinateur en milieu professionnel à Casablanca (Maroc)

    PubMed Central

    Seknaji, Nawal; Rachidi, Wafaa; Hassoune, Samira; Janani, Saadia; Nani, Samira; Maaroufi, Abderrahmane; Mkinsi, Ouafaa

    2013-01-01

    Introduction Les cervicalgies et douleurs du membre supérieur (CDMS) affectent des millions d'utilisateurs d'ordinateurs dans les pays développés. L'objectif de ce travail était de déterminer la prévalence des cervicalgies et douleurs du membre supérieur (CDMS) à Casablanca et identifier les différents facteurs de risque qui y sont impliqués, afin de définir les sous-groupes à haut risque, et d’établir des plans d'intervention efficaces. Méthodes Il s'agit d'une étude transversale, menée chez 118 employés de bureau francophones et utilisant l'ordinateur, à Casablanca. Les données ont été collectées de Décembre 2011 à Juin 2012, en utilisant la version française d'un questionnaire validé: Maastricht-Upper-extremity-Questionnaire. Résultats 118 utilisateurs d'ordinateur en milieu professionnel ont été recrutés. Parmi les employés enquêtés, 93% ont rapporté des CDMS localisées au moins à un site. Les plaintes les plus fréquemment rapportées étaient les douleurs des épaules et les cervicalgies (48,3% et 46,6% respectivement). Nous n'avons pas remarqué de différence significative des fréquences des douleurs selon le genre. Nos résultats concordent avec les données de la littérature où il existe un certain consensus quant à l'impact des mauvaises conditions ergonomiques sur les troubles musculo-squelettiques du membre supérieur en milieu professionnel. De même, les études récentes examinant les effets combinés et/ou interactifs tant des facteurs biomécaniques/physiques que de facteurs psychosociaux professionnels vont de pair avec nos résultats. Conclusion Il en ressort que les stratégies d'intervention visant à réduire les CDMS doivent agir essentiellement sur 3 volets, le premier correspond à l'amélioration et la sensibilisation quant au respect des conditions ergonomiques, le second concerne l'amélioration des conditions psychosociales. Enfin le troisième volet vise la rationalisant de la demande de

  11. Modélisation 2D par Eléments Finis de phénomènes micro-ondes en milieu ouvert

    NASA Astrophysics Data System (ADS)

    Nicolas, L.; Connor, K. A.; Salon, S. J.; Ruth, B. G.; Libelo, L. F.

    1992-11-01

    We present in this paper the modelization of open boundaries microwave problems using Finite Element method, for the design of antennas or for the study of electromagnetic scattering: Finite Element formulation, coupling with Boundary Element Method or with Absorbing Boundary Conditions, modelization of current sources, calculation of far field. In a second part, we show the results concerning a high power microwave launcher. Nous présentons ici notre activité dans le domaine de la modélisation bidimensionnelle de problèmes de de micro-ondes en milieu ouvert, pour la conception d'antennes ou l'étude de problèmes de diffraction électromagnétique: formulation par la méthode des Eléments Finis, prise en compte de l'infini par la méthode des Equations Intégrales de Frontière ou par des conditions aux limites absorbantes, modélisation des sources de courant, calcul du champ lointain. Dans une seconde partie, nous illustrons ces différentes méthodes par la modélisation d'une antenne haute puissance.

  12. EGFR‐targeted Chimeras of Pseudomonas ToxA released into the extracellular milieu by attenuated Salmonella selectively kill tumor cells

    PubMed Central

    Quintero, David; Carrafa, Jamie; Vincent, Lena

    2016-01-01

    ABSTRACT Tumor‐targeted Salmonella VNP20009 preferentially replicate within tumor tissue and partially suppress tumor growth in murine tumor models. These Salmonella have the ability to locally induce apoptosis when they are in direct contact with cancer cells but they lack significant bystander killing, which may correlate with their overall lack of antitumor activity in human clinical studies. In order to compensate for this deficiency without enhancing overall toxicity, we engineered the bacteria to express epidermal growth factor receptor (EGFR)‐targeted cytotoxic proteins that are released into the extracellular milieu. In this study, we demonstrate the ability of the Salmonella strain VNP20009 to produce three different forms of the Pseudomonas exotoxin A (ToxA) chimeric with a tumor growth factor alpha (TGFα) which results in its producing culture supernatants that are cytotoxic and induce apoptosis in EGFR positive cancer cells as measured by the tetrazolium dye reduction, and Rhodamine 123 and JC‐10 mitochondrial depolarization assays. In addition, exchange of the ToxA REDLK endoplasmic reticulum retention signal for KDEL and co‐expression of the ColE3 lysis protein resulted in an overall increased cytotoxicity compared to the wild type toxin. This approach has the potential to significantly enhance the antitumor activity of VNP20009 while maintaining its previously established safety profile. Biotechnol. Bioeng. 2016;113: 2698–2711. © 2016 The Authors. Biotechnology and Bioengineering published by Wiley Periodicals, Inc. PMID:27260220

  13. Acid Gradient across Plasma Membrane Can Drive Phosphate Bond Synthesis in Cancer Cells: Acidic Tumor Milieu as a Potential Energy Source

    PubMed Central

    Dhar, Gautam; Sen, Suvajit; Chaudhuri, Gautam

    2015-01-01

    Aggressive cancers exhibit an efficient conversion of high amounts of glucose to lactate accompanied by acid secretion, a phenomenon popularly known as the Warburg effect. The acidic microenvironment and the alkaline cytosol create a proton-gradient (acid gradient) across the plasma membrane that represents proton-motive energy. Increasing experimental data from physiological relevant models suggest that acid gradient stimulates tumor proliferation, and can also support its energy needs. However, direct biochemical evidence linking extracellular acid gradient to generation of intracellular ATP are missing. In this work, we demonstrate that cancer cells can synthesize significant amounts of phosphate-bonds from phosphate in response to acid gradient across plasma membrane. The noted phenomenon exists in absence of glycolysis and mitochondrial ATP synthesis, and is unique to cancer. Biochemical assays using viable cancer cells, and purified plasma membrane vesicles utilizing radioactive phosphate, confirmed phosphate-bond synthesis from free phosphate (Pi), and also localization of this activity to the plasma membrane. In addition to ATP, predominant formation of pyrophosphate (PPi) from Pi was also observed when plasma membrane vesicles from cancer cells were subjected to trans-membrane acid gradient. Cancer cytosols were found capable of converting PPi to ATP, and also stimulate ATP synthesis from Pi from the vesicles. Acid gradient created through glucose metabolism by cancer cells, as observed in tumors, also proved critical for phosphate-bond synthesis. In brief, these observations reveal a role of acidic tumor milieu as a potential energy source and may offer a novel therapeutic target. PMID:25874623

  14. Does Cattle Milieu Provide a Potential Point to Target Wild Exophilic Anopheles arabiensis (Diptera: Culicidae) with Entomopathogenic Fungus? A Bioinsecticide Zooprophylaxis Strategy for Vector Control.

    PubMed

    Lyimo, Issa N; Ng'habi, Kija R; Mpingwa, Monica W; Daraja, Ally A; Mwasheshe, Dickson D; Nchimbi, Nuru S; Lwetoijera, Dickson W; Mnyone, Ladslaus L

    2012-01-01

    Background. Anopheles arabiensis is increasingly dominating malaria transmission in Africa. The exophagy in mosquitoes threatens the effectiveness of indoor vector control strategies. This study aimed to evaluate the effectiveness of fungus against An. arabiensis when applied on cattle and their environments. Methods. Experiments were conducted under semi-field and small-scale field conditions within Kilombero valley. The semi-field reared females of 5-7 days old An. arabiensis were exposed to fungus-treated and untreated calf. Further, wild An. arabiensis were exposed to fungus-treated calves, mud-huts, and their controls. Mosquitoes were recaptured the next morning and proportion fed, infected, and survived were evaluated. Experiments were replicated three times using different individuals of calves. Results. A high proportion of An. arabiensis was fed on calves (>0.90) and become infected (0.94) while resting on fungus-treated mud walls than on other surfaces. However, fungus treatments reduced fecundity and survival of mosquitoes. Conclusion. This study demonstrates for the first time the potential of cattle and their milieu for controlling An. arabiensis. Most of An. arabiensis were fed and infected while resting on fungus-treated mud walls than on other surfaces. Fungus treatments reduced fecundity and survival of mosquitoes. These results suggest deployment of bioinsecticide zooprophylaxis against exophilic An. arabiensis.

  15. Does Cattle Milieu Provide a Potential Point to Target Wild Exophilic Anopheles arabiensis (Diptera: Culicidae) with Entomopathogenic Fungus? A Bioinsecticide Zooprophylaxis Strategy for Vector Control

    PubMed Central

    Lyimo, Issa N.; Ng'habi, Kija R.; Mpingwa, Monica W.; Daraja, Ally A.; Mwasheshe, Dickson D.; Nchimbi, Nuru S.; Lwetoijera, Dickson W.; Mnyone, Ladslaus L.

    2012-01-01

    Background. Anopheles arabiensis is increasingly dominating malaria transmission in Africa. The exophagy in mosquitoes threatens the effectiveness of indoor vector control strategies. This study aimed to evaluate the effectiveness of fungus against An. arabiensis when applied on cattle and their environments. Methods. Experiments were conducted under semi-field and small-scale field conditions within Kilombero valley. The semi-field reared females of 5–7 days old An. arabiensis were exposed to fungus-treated and untreated calf. Further, wild An. arabiensis were exposed to fungus-treated calves, mud-huts, and their controls. Mosquitoes were recaptured the next morning and proportion fed, infected, and survived were evaluated. Experiments were replicated three times using different individuals of calves. Results. A high proportion of An. arabiensis was fed on calves (>0.90) and become infected (0.94) while resting on fungus-treated mud walls than on other surfaces. However, fungus treatments reduced fecundity and survival of mosquitoes. Conclusion. This study demonstrates for the first time the potential of cattle and their milieu for controlling An. arabiensis. Most of An. arabiensis were fed and infected while resting on fungus-treated mud walls than on other surfaces. Fungus treatments reduced fecundity and survival of mosquitoes. These results suggest deployment of bioinsecticide zooprophylaxis against exophilic An. arabiensis. PMID:22934152

  16. A grid matrix-based Raman spectroscopic method to characterize different cell milieu in biopsied axillary sentinel lymph nodes of breast cancer patients.

    PubMed

    Som, Dipasree; Tak, Megha; Setia, Mohit; Patil, Asawari; Sengupta, Amit; Chilakapati, C Murali Krishna; Srivastava, Anurag; Parmar, Vani; Nair, Nita; Sarin, Rajiv; Badwe, R

    2016-01-01

    Raman spectroscopy which is based upon inelastic scattering of photons has a potential to emerge as a noninvasive bedside in vivo or ex vivo molecular diagnostic tool. There is a need to improve the sensitivity and predictability of Raman spectroscopy. We developed a grid matrix-based tissue mapping protocol to acquire cellular-specific spectra that also involved digital microscopy for localizing malignant and lymphocytic cells in sentinel lymph node biopsy sample. Biosignals acquired from specific cellular milieu were subjected to an advanced supervised analytical method, i.e., cross-correlation and peak-to-peak ratio in addition to PCA and PC-LDA. We observed decreased spectral intensity as well as shift in the spectral peaks of amides and lipid bands in the completely metastatic (cancer cells) lymph nodes with high cellular density. Spectral library of normal lymphocytes and metastatic cancer cells created using the cellular specific mapping technique can be utilized to create an automated smart diagnostic tool for bench side screening of sampled lymph nodes. Spectral library of normal lymphocytes and metastatic cancer cells created using the cellular specific mapping technique can be utilized to develop an automated smart diagnostic tool for bench side screening of sampled lymph nodes supported by ongoing global research in developing better technology and signal and big data processing algorithms.

  17. Potentiel des images satellitaires multibandes a haute resolution spatiale pour la cartographie des componsants de l'eau en milieu cotier marin

    NASA Astrophysics Data System (ADS)

    Lavoie, Andre

    L'objectif principal que que nous poursuivons est de developper un modele de simulation du transfert radiatif eau-atmosphere adapte aux observations faites par le capteur Thematic Mapper (TM) de Landsat. Les informations que nous cherchons ont trait au milieu cotier marin et concernent les elements qui sont en suspension dans l'eau. Les images multibandes du capteur TM dans la partie visible du spectre, sont surtout visees par nos travaux. A la base de la simulation, nous utilisons un programme de simulation atmospherique, le code 6S, auquel nous greffons un modele de simulation du transfert radiatif dans la masse d'eau. Ce dernier estime le signal en fonction de 4 composants: l'eau, les pigments chlorophylliens (chlorophylle et phaeopigments), les matieres minerales et les substances organiques dissoutes. La concentration des differents composants sert de parametre d'entree pour definir le comportement optique de la masse d'eau. Le modele permet egalement de simuler une masse d'eau stratifiee si l'on connai t les concentrations des composants dans les differentes couches. Il inclut aussi la contribution du fond, selon sa nature et sa composition, ainsi que celle du miroitement du soleil et du ciel a la surface de l'eau. Les informations d'un echantillonnage de la masse d' eau synchronise avec le passage du satellite, a la baie des Chaleurs, d'une cartographie du couvert d'algues et d'un modele bathymetrique ont ete utilisees pour fixer les parametres de simulation par le modele. La comparaison montrent que le modele se comporte relativement bien surtout dans la bande TM2. Une erreur systematique de 2 valeurs numeriques en moyenne subsiste dans les trois bandes spectrales. Les resultats nous montrent que la visibilite du fond aux faibles profondeurs est un element tres important a considerer. Par ailleurs, l'analyse de sensibilite montre que les images TM sont plus sensibles aux concentrations en matieres minerales qu'aux pigments chlorophylliens et aux substances

  18. Diabète en milieu urbain de Ouagadougou au Burkina Faso: profil épidémiologique et niveau de perception de la population adulte

    PubMed Central

    Millogo, Georges Rosario Christian; Yaméogo, Clément; Samandoulougou, André; Yaméogo, Nobila Valentin; Kologo, Koudougou Jonas; Toguyeni, Jean Yves; Zabsonré, Patrice

    2015-01-01

    Introduction L'accroissement rapide de la prévalence du diabète sucré en Afrique subsaharienne constitue un problème de santé public. L'Organisation Mondiale de la Santé (OMS) estime qu’à l'horizon 2025, l'augmentation la plus significative de la prévalence du diabète sera enregistrée dans les pays en développement. Ceux-ci devraient abriter 75% des patients diabétiques du monde. Outre ses complications métaboliques, le diabète est un facteur de risque cardiovasculaire majeur. Le but de notre étude était de decrire le profil épidémiologique du diabète et d’évaluer le niveau de perception de la maladie par une population africaine en milieu urb qwqain de Ouagadougou. Méthodes Le diabète a été défini chez tout sujet ayant une glycémie casuelle supérieure à 2 g/L ou une glycémie à jeun supérieur ou égale à 1,26 g/L (≥ 7 mmol/L) à deux controles d'une semaine d'intervalle. Etaient considérés diabétique, les sujets déjà suivis et ceux nouvellement dépistés par l'etude. Résultats L’étude a inclus 1532 personnes, d’âge compris entre 25 et 64 ans dont 55,6% d'hommes et 44,4% de femmes. L’âge moyen était 36,10 ± 11,19 ans. La tranche d’âge de 25 à 34 ans était la plus représentée avec une proportion de 57,1%. La glycémie moyenne était de 1,04 g/L, la proportion des femmes ayant une hyperglycémie était statistiquement plus importante que celle des hommes (p< 0,05). Près de 81,3% de la population ignoraient que le diabète était un facteur de risque cardiovasculaire. Conclusion Il est urgent de mettre en place un programme national de lutte contre le diabète sucré et les autres maladies non transmissibles au Burkina Faso. PMID:26524982

  19. EPR-Spin Trapping and Flow Cytometric Studies of Free Radicals Generated Using Cold Atmospheric Argon Plasma and X-Ray Irradiation in Aqueous Solutions and Intracellular Milieu

    PubMed Central

    Uchiyama, Hidefumi; Zhao, Qing-Li; Hassan, Mariame Ali; Andocs, Gabor; Nojima, Nobuyuki; Takeda, Keigo; Ishikawa, Kenji; Hori, Masaru; Kondo, Takashi

    2015-01-01

    intracellular milieu is discussed. PMID:26318000

  20. Inhibition de la corrosion d'acier au carbone en milieu H3PO4 2M par des composés organiques de type ``triazine''

    NASA Astrophysics Data System (ADS)

    Bekkouch, K.; Aouniti, A.; Hammouti, B.; Kertit, S.

    1999-05-01

    The effect of addition of some triazine compounds on the corrosion behaviour of steel in 2M H3PO4 has been studied by weight loss and electrochemical polarisation methods. Both methods showed that the dissolution rate was dependent on the chemical properties and concentration of the product. From comparison of results, it was found that 6-azathymine (T6) is the best inhibitor and its inhibition efficiency reaches a maximum value of 86% at 10-3 M. Polarisation measurements indicated that T6 acts as cathodic inhibitor by merely blocking the reaction sites without changing the mechanism of the hydrogen evolution reaction. It was found that T6 was adsorbed on steel surface according to a Langmuir isotherm model. The effect of temperature indicated that inhibition efficiency of T6 is dependent on the temperature in the range 25-50 circC. L'effet de l'addition de certains composés organiques de type triazine sur la corrosion d'un acier en milieu H3PO4 2M a été étudié à l'aide des méthodes électrochimiques et gravimétriques. Les résultats obtenus ont montré que la vitesse de dissolution de l'acier dépend de la structure moléculaire et de la concentration du produit. La comparaison des efficacités inhibitrices montre que le 6-azathymine (T6) est le meilleur inhibiteur de la série des triazines testés. L'efficacité inhibitrice du T6 atteint une valeur maximale de 86 % à 10-3 M. L'allure des courbes de polarisation indique que le T6 agit essentiellement comme inhibiteur de type cathodique par adsorption à la surface de l'acier selon le modèle de l'isotherme de Langmuir. L'efficacité inhibitrice du T6 dépend de la température dans le domaine allant de 25 à 50 circC.

  1. S100A8 and S100A9 are messengers in the crosstalk between epidermis and dermis modulating a psoriatic milieu in human skin

    SciTech Connect

    Lee, Young; Jang, Sunhyae; Min, Jeong-Ki; Lee, Kyungmin; Sohn, Kyung-Cheol; Lim, Jong-Soon; Im, Myung; Lee, Hae-Eul; Seo, Young-Joon; Kim, Chang-Deok; Lee, Jeung-Hoon

    2012-07-13

    Highlights: Black-Right-Pointing-Pointer Upregulated S100A8 and/or S100A9 in psoriasis epidermis induce cytokine production. Black-Right-Pointing-Pointer Upregulated S100A8 and/or S100A9 in psoriasis epidermis induce migration of immune cells. Black-Right-Pointing-Pointer Upregulated S100A8 and/or S100A9 in psoriasis epidermis induce angiogenesis. Black-Right-Pointing-Pointer S100A8 and/or S100A9 may play a role in the crosstalk between epidermis and dermis in psoriasis. -- Abstract: S100A8 and S100A9 are members of the S100A8 protein family that exist as homodimers and heterodimers in neutrophils, monocytes, and macrophages. Recent studies have shown the pivotal roles of S100A8 and S100A9 in the propagation of inflammation and keratinocyte proliferation in psoriasis. We found significant up-regulation of S100A8 and S100A9 secretion from keratinocytes in psoriatic lesions. To mimic the in vivo secretory conditions of S100A8 and S100A9 from psoriatic epidermal keratinocytes, we used the culture medium (CM) of S100A8 and S100A8/A9 adenovirus-transduced keratinocytes to investigate the functions of S100A8 and S100A9. We detected increased levels of various pro-inflammatory cytokines in the CM, including IL-8 and TNF-{alpha}, which are involved in aggravating psoriatic skin lesions, and IL-6 and members of the CXCL family of pro-angiogenic cytokines. The CM increased immune cell migration and increased angiogenesis in human umbilical vein endothelial cells. In conclusion, we found that the upregulated production of S100A8 and S100A9 by psoriatic epidermal keratinocytes activated adjacent keratinocytes to produce several cytokines. Moreover, S100A8 and S100A9 themselves function as pro-angiogenic and chemotactic factors, generating a psoriatic milieu in skin.

  2. Signes cliniques rencontrés chez l'enfant malnutri dans un milieu minier: cas de la ville de Lubumbashi et ses environs

    PubMed Central

    Musimwa, Aimée Mudekereza; Kanteng, Gray Wakamb; Kitoko, Hermann Tamubango; Luboya, Oscar Numbi

    2016-01-01

    Introduction La malnutrition reste à ce jour un problème majeur de santé publique, notamment dans les pays en voie de développement. Cette étude a eu pour objectif de déterminer les signes cliniques observés chez l'enfant mal nourri, admis dans une unité de prise en charge. Méthodes Il s'agit d'une étude descriptive transversale, effectuée de juillet 2013 à décembre 2014. 311 cas ont été colligés (182 malnutris et 129 biens nourris), par échantillonnage exhaustif, avec un dépistage actif des enfants malnutris et biens nourris. Le diagnostic est fait cliniquement associé à l'anthropométrie. Résultats Les signes les plus enregistrés chez les enfants malnutris étaient dominés par la toux ou pneumopathie dans 42,50%, la gastroentérite dans 38,55%, les lésions dermatologiques ont présenté 22,91% de cas, la fièvre dans 22,35% de cas, 19,0% des enfants ont présenté les œdèmes, 8,38% d'enfants ont présenté la pâleur, enfin hépatomégalie et splénomégalie sont les signes les moins fréquents avec respectivement 1,68% et 2,89%. Tandis que les enfants en bonne état nutritionnel ont présenté plus la splénomégalie et la fièvre qui seraient liés au paludisme. Conclusion Les enfants malnutris vivant dans un milieu minier présentent une symptomatologie qui ne pas différents de autres enfants mal nourris à l'exception de l'hépatomégalie et splénomégalie qui sont très rare chez nos mal nourris. PMID:27642407

  3. EPR-Spin Trapping and Flow Cytometric Studies of Free Radicals Generated Using Cold Atmospheric Argon Plasma and X-Ray Irradiation in Aqueous Solutions and Intracellular Milieu.

    PubMed

    Uchiyama, Hidefumi; Zhao, Qing-Li; Hassan, Mariame Ali; Andocs, Gabor; Nojima, Nobuyuki; Takeda, Keigo; Ishikawa, Kenji; Hori, Masaru; Kondo, Takashi

    2015-01-01

    intracellular milieu is discussed.

  4. Facteurs de risque de faible poids de naissance en milieu semi-rural de Kamina, République Démocratique du Congo

    PubMed Central

    Kangulu, Ignace Bwana; Umba, Elie Kilolo Ngoy; Nzaji, Michel Kabamba; Kayamba, Prosper Kalenga Mwenze

    2014-01-01

    Introduction Le faible poids de naissance constitue un problème majeur de santé publique, aussi bien dans les pays développés que dans les pays en développement, de par son ampleur et sa forte association avec la morbidité et la mortalité infantiles. Méthodes Il s’agit d’une étude cas-témoins rétrospective menée sur les différents facteurs de risque de faible poids de naissance(FPN) en milieu semi-rural de Kamina chez les accouchées et leurs nouveau-nés respectifs enregistrés de la période allant de janvier 2009 à décembre 2010. Résultats Cette étude a répertorié 69 cas des nouveau-nés de FPN sur 483 accouchements enregistrés (14,3%). Les facteurs associés au FPN déterminés dans ce travail sont l’âge maternel inférieur à 18 ans (OR=7,62, IC=3.46-16.8) et supérieur à 35 ans (OR=2,04;IC=0.91-4.46), la primiparité(OR=2,48;IC=1.18-5.21) et le non suivi des consultations prénatales (OR=5,50;IC=2.00-15.03), la prématurité avec grossesse âgée de moins de 37 semaines d’aménorrhée, la grossesse multiple (OR=30,94) et le sexe féminin du nouveau-né. Conclusion Cette étude a démontré que l’âge maternel inférieur à 18 ans et supérieur à 35 ans, le non suivi des consultations prénatales, la primiparité et la prématurité, la grossesse multiple et le sexe féminin du nouveau-né sont les facteurs associés au faible poids de naissance. PMID:25237417

  5. Effets de la taille finie du milieu non-linéaire sur le bruit quantique spatial généré par un oscillateur paramétrique optique confocal

    NASA Astrophysics Data System (ADS)

    Lopez, L.; Gatti, A.; Maitre, A.; Treps, N.; Gigan, S.; Fabre, C.

    2004-11-01

    Nous nous intéressons au comportement spatial des fluctuations quantiques à la sortie d'un oscillateur paramétrique optique dégénéré en modes transverses, sous le seuil. En vue de futures expériences, nous étudions les effets de la diffraction dans le milieu paramétrique sur le bruit quantique spatial. Nous montrons que l'on voit apparaître une aire de cohérence de taille finie pour les effets quantiques transverses.

  6. L'hemorragie grave du peripartum en milieu de reanimation dans un centre universitaire tunisien de niveau 3: épidémiologie et facteurs de risque de mortalité maternelle

    PubMed Central

    Nasr, Laidi Ben; Marzouk, Sofiene Ben; Kehila, Mehdi; Jabri, Hamed; Thamleoui, Saber; Maghrebi, Hayen

    2015-01-01

    L'hémorragie grave du péripartum demeure une des causes principales de mortalité maternelle. L'objectif de notre étude était de décrire le profil épidémiologique des patientes qui ont été prises en charge en milieu de réanimation suite à une hémorragie grave du péripartum et de rechercher d’éventuels facteurs de risque de mortalité. Notre étude est rétrospective descriptive et analytique. Nous avons inclus tous les cas d'hémorragie du péripartum ayant séjourné en unité de réanimation obstétricale du centre de maternité et de néonatologie de Tunis (CMNT) au cours de la période allant de janvier 2010 à Décembre 2013. Nous avons recueilli les paramètres démographiques, obstétricaux, ceux relatifs à la prise en charge chirurgicale et réanimatoire, les scores de gravité SAPS obstétrical et APACHEII, ainsi que la morbi-mortalité. Au total nous avons colligé 322 cas sur quatre ans. La répartition annuelle des patientes ainsi que les caractéristiques démographiques et obstétricales étaient comparables dans leur globalité sur les quatre années. Les pratiques thérapeutiques étaient également comparables. Le taux global de mortalité par hémorragie dans notre unité était à 4,7%, avec un taux annuel de mortalité stable. L'analyse des facteurs de risque de mortalité par hémorragie en milieu de réanimation a montré une association statistiquement significative entre la survenue du décès et les facteurs suivants: recours aux catécholamines, survenue de sepsis, œdème pulmonaire aigu, coagulation intravasculaire disséminée, insuffisance rénale aigue avec recours à l'hémodialyse, SDRA ou TRALI, atteinte neurologique grave, défaillance multiviscérale et arrêt cardiaque récupéré. PMID:26587127

  7. IL4 and IL-17A provide a Th2/Th17-polarized inflammatory milieu in favor of TGF-β1 to induce bronchial epithelial-mesenchymal transition (EMT)

    PubMed Central

    Ji, Xiaoying; Li, Jinxiu; Xu, Li; Wang, Wenjing; Luo, Ming; Luo, Shuangling; Ma, Libing; Li, Keng; Gong, Subo; He, Long; Zhang, Zhijun; Yang, Ping; Zhou, Zhiguang; Xiang, Xudong; Wang, Cong-Yi

    2013-01-01

    Severe asthma is a chronic airway disease characterized by the Th2/Th17-polarized inflammation along with permanent airway remodeling. Despite past extensive studies, the exact role for Th2 and Th17 cytokines in asthmatic pathoetiology, particularly in the pathogenesis of bronchial epithelial-mesenchymal transition (EMT), is yet to be fully addressed. We herein conducted studies in 16-HBE cells and demonstrated that Th2-derived IL-4 and Th17-derived IL-17A provide a chronic inflammatory milieu that favors TGF-β1 to induce bronchial EMT. A synergic action was noted between TGF-β1, IL-4 and IL-17A in terms of induction of EMT. IL-4 and IL-17A synergized with TGF-β1 to induce epithelial cells re-entering cell cycle, and to promote epithelial to mesenchymal morphological transistion, and by which they enhanced the capacity of TGF-β1 to suppress E-cadherin expression, and to induce a-SMA expression in epithelial cells. Mechanistic studies revealed that this synergic action is coordinated by the regulation of ERK1/2 activity. Our results not only provide a novel insight into the understanding of the mechanisms underlying airway remodeling in asthmatic condition, but also have the potential for developing more effective therapeutic strategies against severe asthmatics in clinical settings. PMID:23923066

  8. Analysis of a cultural consensus model of two good-life sub-domains--health & well-being and migration & socioeconomic milieu--in three population groups in Croatia.

    PubMed

    Peternel, Lana; Malnar, Ana; Klarić, Irena Martinović

    2015-07-01

    In this study the construct of a 'good life' was explored among upper secondary school senior pupils and their parents and teachers by applying cultural consensus model analysis. A total of 469 students, 474 parents and 158 teachers from four Croatian cities participated in the study, which was conducted in 2011/2012. The information collected through interviewing and free-listing during the first phase of the study was used to create a set of structured questionnaire questions as a part of the survey in the second phase of data collection. The results are reported on two good-life sub-domains: 'health & well-being' and 'migration & socioeconomic milieu'. The results indicate heterogeneity of the sample groups, incomplete inter-generational transmission of cultural values and examples of two sub-groups that resist cultural norms and do not comply with the dominant 'competence-as-sharing' paradigm. The value of testing the cultural consensus model based on the emic approach and locally significant phenomena is demonstrated for planning and conducting holistic anthropological research.

  9. Temptation and Seduction in the Technological Milieu

    ERIC Educational Resources Information Center

    van der Laan, J. M.

    2004-01-01

    Jacques Ellul's work on propaganda provides the basis for this analysis of life in technology. Advertising and the mass media rely on temptation and seduction and create a constant flow of propaganda, all of which serve the technological system. Propaganda aims to condition and regulate us so that we participate in and adapt ourselves to a desired…

  10. [Tibiotarsal arthrodesis in a septic milieu].

    PubMed

    Lortat-Jacob, A; Beaufils, P; Coignard, S; Elahmadi, J

    1984-01-01

    The authors have performed 28 ankle fusions for septic causes. There were 23 cases of septic arthritis and 5 severely comminuted compound fractures treated by primary fusion. Arthrodesis was made after wide excision and stabilization by external fixator. In 23 cases secondary bone grafting was done. Only in 13 cases was a satisfactory contact between the bony surfaces obtained. There was no contact at all in 9 cases. The authors have had good experience with the A.L.J. model of external fixator. On 7 occasions, secondary grafting was made using a cortico-cancellous graft with 3 failures. On 6 occasions, the Papineau technique was used with success but healing was slow. Out of 24 patients, the final result was good in 18 with 4 failures of fusion and 3 persistent sinuses. The importance of a wide excision is emphasised leading to the need for the use of external fixation. In cases of skin loss in recent comminuted fractures, the Papineau method is indicated as a primary procedure.

  11. Étude par détection de photons des processus électroniques au sein d'une jonction tunnel dans un milieu moléculaire

    NASA Astrophysics Data System (ADS)

    Perronet, K.

    2005-03-01

    Analysis of the luminescence induced by a STM (scanning tunneling microscope) permits to get insights into the electronic processes taking place in a single nanoscopic tunnel junction. We studied a Au(111)/Au junction under vacuum (UHV) and immersed in a molecular medium. The study under UHV reveals the influence of spatial variations of surface local density of states (LDOS) on the luminescence. The emission at the solid-liquid interface is characterized and the role played by the dielectric function is shown. Time correlations between the emitted single photons are then studied. Depending on the liquid immersing the junction, a photon bunching can occur. We link this bunching with structural changes of the junction induced by the presence of a diffusing molecule. If the HOMO LUMO gap of the molecule is small enough, resonant tunnelling paths exist and tunnelling-electron bunching occurs. Finally, the influence of a self-assembled monolayer on the substrate is investigated. Boundings between triphenylene derivatives and Au(111) are too weak, but with chemisorbed alcanethiols, molecular resolution is reached both on the STM image and on the photon map. We show that the contrast on photon map comes from the modulation of the LDOS spatial extension into the barrier due to the S Au bond. The elaboration of organic multilayers is considered as a route for observing the electroluminescence of a single molecule, isolated from the substrate by thiols and to study correlations of electronic origin. We have already optically characterised such a layer using C{60}. La luminescence induite par STM (microscopie à effet tunnel) est une source d'informations d'une grande richesse sur les processus électroniques au sein d'un objet nanoscopique individuel. Nous nous sommes intéressés à une jonction Au/Au(111) sous vide puis dans un milieu moléculaire. L'étude sous vide a permis de montrer l'influence des variations spatiales des densités d'états de la surface. L

  12. The Roosevelt years: crucial milieu for Carl Rogers' innovation.

    PubMed

    Barrett-Lennard, Godfrey T

    2012-02-01

    This study explores broad features of political culture and event of the 1930s and World War 2 years, viewed in relation to the emergence and rapid early growth of the new therapy of Carl Rogers. The paper traces Rogers' early professional life and examines distinctive emphases in sociopolitical thought and development during Franklin D. Roosevelt's leadership as President over the prolonged emergency of the Great Depression and the crisis of the War. The study includes a focus on the President's own outlook and style, pertinent New Deal innovations, and wartime needs. Twelve features of this larger context are discriminated as together having vital importance for the new therapy and its founder. The congruent courses of the macrocontext and of Rogers' innovation are followed to the ending of Roosevelt's life. Direct causation is not attributed, but the evidence adduced newly points to particular contours of a larger environment favorable for the expression of Rogers' values and rare ability. In sum, the author concludes that a synergy of highly conducive historical circumstance and individual exceptionality contributed to the philosophical underpinnings, attitudinal values and early momentum of Rogers' client-centered therapy.

  13. Telemedicine: socio-ethical considerations in the Indian milieu.

    PubMed

    Sharma, Luv K; Rajput, Meena

    2009-01-01

    Telemedicine is the rapidly developing application of clinical medicine by telephone, the internet or other networks for the purpose of consulting, and on occasions carrying out examinations or medical procedures. Telemedicine may be as simple as two health professionals discussing a case over the telephone, or as complex as using satellite technology and video-conferencing equipment to conduct a real-time consultation between medical specialists in two different countries. Telemedicine offers real benefits in a country as vast as India where the majority of the population lives in remote areas with no access to even the most basic healthcare. As the practice of telemedicine spreads, maintaining standards, security and privacy, will be a challenge especially with regard to legal and regulatory measures and who will be held responsible if telemedicine-assisted surgery fails due to failure in connectivity? Is it the surgeon, the satellite provider or the software/hardware engineer? What is the legal status of telemedicine-based diagnosis and treatment? Other legal issues involve conflicting national laws and information piracy, the dangers of prescription drugs that are banned in one country but not in another and quacks who offer medical advice and prescribe drugs over the internet. This paper discusses some of the legal, ethical and social considerations in the Indian context.

  14. Chronic Glucocorticoid-Rich Milieu and Liver Dysfunction

    PubMed Central

    Castro, María Cecilia

    2016-01-01

    We investigated the impact of chronic hypercorticosteronemia (due to neonatal monosodium L-glutamate, MSG, and treatment) on liver oxidative stress (OS), inflammation, and carbohydrate/lipid metabolism in adult male rats. We evaluated the peripheral concentrations of several metabolic and OS markers and insulin resistance indexes. In liver we assessed (a) OS (GSH and protein carbonyl groups) and inflammatory (IL-1b, TNFa, and PAI-1) biomarkers and (b) carbohydrate and lipid metabolisms. MSG rats displayed degenerated optic nerves, hypophagia, low body and liver weights, and enlarged adipose tissue mass; higher peripheral levels of glucose, triglycerides, insulin, uric acid, leptin, corticosterone, transaminases and TBARS, and peripheral and liver insulin resistance; elevated liver OS, inflammation markers, and glucokinase (mRNA/activity) and fructokinase (mRNA). Additionally, MSG liver phosphofructokinase-2, glucose-6-phosphatase (mRNA and activity) and glucose-6-phosphate dehydrogenase, Chrebp, Srebp1c, fatty acid synthase, and glycerol-3-phosphate (mRNAs) were increased. In conclusion adult MSG rats developed an insulin-resistant state and increased OS and serious hepatic dysfunction characterized by inflammation and metabolic signs suggesting increased lipogenesis. These features, shared by both metabolic and Cushing's syndrome human phenotypes, support that a chronic glucocorticoid-rich endogenous environment mainly impacts on hepatic glucose cycle, displacing local metabolism to lipogenesis. Whether correcting the glucocorticoid-rich environment ameliorates such dysfunctions requires further investigation. PMID:27597864

  15. Le pompage optique naturel dans le milieu astrophysique

    NASA Astrophysics Data System (ADS)

    Pecker, J.-C.

    The title of this lecture abstracts only a part of it : the importance in astrophysics of the study of non-LTE situations has become considerable, as well in the stellar atmospheres as, still more, in the study of fortuitous coincidences as a mechanism of formation of emission line nebular spectra, or of molecular interstellar « masers ». Another part of this talk underlines the role of Kastler in his time, and describes his warm personality through his public reactions in front of the nuclear armement, of the Viet-Nam and Algerian wars, of the problems of political refugees... Kastler was a great scientist ; he was also a courageous humanist. 1976 : Les accords nucléaires du Brésil : allocution d'ouverture (19 mars). Colloque sur le sujet ci-dessus. 1976 : La promotion de la culture dans le nouvel ordre économique international, allocution à l'occasion d'une table ronde sur ce thème par l'UNESCO (23-27 juin 1976) ; « Sciences et Techniques », octobre 1976. 1979 : La bête immonde (avec J.-C. Pecker), « Le Matin », 20 mars. 1979 : Appel à nos ministres (avec J.-C. Pecker), « Le Monde », 13 décembre. 1979 : Le flou, le ténébreux, l'irrationnel (avec J.-C. Pecker), « Le Monde », 14 septembre. 1980 : Education à la paix, Préface, in : Publ. UNESCO. 1981 : Le vrai danger, « Le Monde », 6 août 1981. 1982 : Nucléaire civil et militaire, « Le Monde », 1er juin 1982. 1982 : Les scientifiques face à la perspective d'holocauste nucléaire (texte inédit). Le titre de cette communication en résume seulement une partie : l'importance prise en astrophysique par l'analyse des situations hors ETL est devenue considérable, qu'il s'agisse des atmosphères stellaires, ou plus encore, des coïncidences fortuites de la formation des spectres d'émission nébulaires, ou des « masers » moléculaires interstellaires. Une autre partie de cet exposé souligne le rôle de Kastler dans son époque, et décrit sa personnalité généreuse à travers ses réactions publiques face à l'armement nucléaire, aux guerres de Viet-Nam et d'Algérie, aux problèmes des réfugiés politiques... Kastler était un grand savant, mais aussi un homme courageux.

  16. [Study of neonatal malnutrition risk in the Zaire milieu].

    PubMed

    Tandu-Umba, N F; Mputa Lobota, A; Bouillon, R

    1996-01-01

    This study is intended to assess neonatal risk of malnutrition owed to maternal energy intake lower than 2000 kcal/day among Zairian primiparae. Ninety-eight mother-neonate couples were classified according to the level of maternal energy intake. Neonatal albuminemia which previously showed itself as neonatal nutritional marker served for grouping neonates. Possibility of reaching optimal albuminemia value (29,34 g/l) was assessed according to different maternal energy profiles, using U-test and Chi 2. When maternal intake is lower than 2000 kcal/day, neonatal optimum is reached in 26% of cases; when maternal recommendation is lowered to 1675,21 kcal/day, neonatal optimum is reached in 63,43% of cases; with 2000 kcal/day as recommendation, this rate rises up to 71,4%. Under 2000 kcal/day neonatal risk of malnutrition is thus very high.

  17. Value orientations and social attitudes in the holistic milieu.

    PubMed

    Höllinger, Franz

    2017-04-01

    Based on a representative population survey for Germany this article investigates whether engagement in holistic activities is associated with privatized lifestyles and lack of social responsibility or with countercultural orientations and base-democratic political commitment. To analyse this question, respondents who are engaged in holistic activities are divided into three groups that are compared with each other as well as with Christians and non-religious people. The findings show that the three holistic groups are characterized by clearly different attitudinal patterns: Respondents engaged in body-mind-spirit activities have an affinity to self-directed ways of life, post-materialism and environmentalism. Holistic Christians try to combine the Christian ideal of altruism and post-materialist orientations. Those who are attracted only to magical-occult practices are primarily concerned with individualistic self-improvement and correspond more to the image of the hedonist consumer at the esoteric marketplace.

  18. China’s New Media Milieu: Commercialization, Continuity, and Reform

    DTIC Science & Technology

    2010-10-01

    Business Herald; ershiyi shiji jingji baodao; 21 世纪经济报道 21st Century World Herald; ershiyi shiji huanqiu baodao; 21 世纪环球报道 American Studies...民联合报业 Wen Wei Po; wen hui bao; 文汇报 Wide Angle; guangjiaojing yuekan; 广角镜月刊 World Economics and Politics; shijie jingji yu zhengzhi; 世界经济与政治 World ...Standing Committee RMB - Renminbi SARS – Severe Acute Respiratory Syndrome SEZ – Special Economic Zone SOE – State Owned Enterprise WTO – World Trade

  19. Teaching Your Tot to Talk: Using Milieu Teaching Strategies

    ERIC Educational Resources Information Center

    Curiel, Emily S. L.; Sainato, Diane M.

    2016-01-01

    Both of these toddlers struggle with communication. Parents and practitioners working with very young children often struggle to find ways to enhance their toddlers' communication skills. They may question: When do I teach? What should I teach? Where do I teach? How do I teach? This article will provide suggestions and techniques to support the…

  20. Chronic Glucocorticoid-Rich Milieu and Liver Dysfunction.

    PubMed

    Villagarcía, Hernán Gonzalo; Sabugo, Vanesa; Castro, María Cecilia; Schinella, Guillermo; Castrogiovanni, Daniel; Spinedi, Eduardo; Massa, María Laura; Francini, Flavio

    2016-01-01

    We investigated the impact of chronic hypercorticosteronemia (due to neonatal monosodium L-glutamate, MSG, and treatment) on liver oxidative stress (OS), inflammation, and carbohydrate/lipid metabolism in adult male rats. We evaluated the peripheral concentrations of several metabolic and OS markers and insulin resistance indexes. In liver we assessed (a) OS (GSH and protein carbonyl groups) and inflammatory (IL-1b, TNFa, and PAI-1) biomarkers and (b) carbohydrate and lipid metabolisms. MSG rats displayed degenerated optic nerves, hypophagia, low body and liver weights, and enlarged adipose tissue mass; higher peripheral levels of glucose, triglycerides, insulin, uric acid, leptin, corticosterone, transaminases and TBARS, and peripheral and liver insulin resistance; elevated liver OS, inflammation markers, and glucokinase (mRNA/activity) and fructokinase (mRNA). Additionally, MSG liver phosphofructokinase-2, glucose-6-phosphatase (mRNA and activity) and glucose-6-phosphate dehydrogenase, Chrebp, Srebp1c, fatty acid synthase, and glycerol-3-phosphate (mRNAs) were increased. In conclusion adult MSG rats developed an insulin-resistant state and increased OS and serious hepatic dysfunction characterized by inflammation and metabolic signs suggesting increased lipogenesis. These features, shared by both metabolic and Cushing's syndrome human phenotypes, support that a chronic glucocorticoid-rich endogenous environment mainly impacts on hepatic glucose cycle, displacing local metabolism to lipogenesis. Whether correcting the glucocorticoid-rich environment ameliorates such dysfunctions requires further investigation.

  1. Communiquer en milieu interculturel (Communicating in an Intercultural Environment).

    ERIC Educational Resources Information Center

    Yanaprasart, Patchareerat, Ed.

    2002-01-01

    The articles, written in French, in this issue refer to research and intercultural practices with regard to confrontational situations between two or more cultural systems. The titles are as follows: "La culture universitaire comme culture en soi" (The University Culture as a Culture in Its Own Right) (Aline Gohard-Radenkovic);…

  2. Complement modulates the cutaneous microbiome and inflammatory milieu

    PubMed Central

    Chehoud, Christel; Rafail, Stavros; Tyldsley, Amanda S.; Seykora, John T.; Lambris, John D.; Grice, Elizabeth A.

    2013-01-01

    The skin is colonized by a plethora of microbes that include commensals and potential pathogens, but it is currently unknown how cutaneous host immune mechanisms influence the composition, diversity, and quantity of the skin microbiota. Here we reveal an interactive role for complement in cutaneous host–microbiome interactions. Inhibiting signaling of the complement component C5a receptor (C5aR) altered the composition and diversity of the skin microbiota as revealed by deep sequencing of the bacterial 16S rRNA gene. In parallel, we demonstrate that C5aR inhibition results in down-regulation of genes encoding cutaneous antimicrobial peptides, pattern recognition receptors, and proinflammatory mediators. Immunohistochemistry of inflammatory cell infiltrates in the skin showed reduced numbers of macrophages and lymphocytes with C5aR inhibition. Further, comparing cutaneous gene expression in germ-free mice vs. conventionally raised mice suggests that the commensal microbiota regulates expression of complement genes in the skin. These findings demonstrate a component of host immunity that impacts colonization of the skin by the commensal microbiota and vice versa, a critical step toward understanding host–microbe immune mutualism of the skin and its implications for health and disease. Additionally, we reveal a role for complement in homeostatic host–microbiome interactions of the skin. PMID:23980152

  3. Creating a Critical Literacy Milieu in a Kindergarten Classroom

    ERIC Educational Resources Information Center

    Stribling, Stacia M.

    2014-01-01

    The purpose of this study was to better understand the process of engaging in critical literacy practices with kindergarteners. The researcher spent six months in a kindergarten classroom taking extensive field notes on the ways in which the teacher and students explored issues of social justice through literacy activities. Data analysis using a…

  4. Fluorescence quenching studies of tryptophan by trivalent lanthanide ions in aqueous media. Evidence for a lanthanide-induced intersystem crossing singlet-to-triplet mechanism

    NASA Astrophysics Data System (ADS)

    Gaye-Seye, M. D.; Aaron, J. J.

    1999-09-01

    The quenching of tryptophan fluorescence by trivalent lanthanide ions is studied at room temperature in aqueous non buffered (pH 5.8) and in 0.05 M HEPES pH 7.5 and acetate pH 5.8 buffered solutions. Bimolecular quenching rate constants ranged between 0.9× 109 and 24.4×109 M-1s-1 in HEPES buffer, and 1.8×109 and 20.7×109 in acetate buffer and between 2.0×109 and 22×109 M-1s-1 in non buffered aqueous solution, according to the nature of the ions. A mechanism involving a lanthanide-induced intersystem crossing singlet-to-triplet process is proposed. The induced intersystem crossing rate constants (kiscind) range from 2.0×107 to 4.7×107 M-1s-1. In aqueous media, kiscind are correlated with the molecular weight of the lanthanide ions under study. L'effet de l'extinction de la fluorescence du tryptophane par des ions lanthanides trivalents a été étudié à 298 K en milieu aqueux (pH 5.8) et en solutions tampon HEPES 0.05 M pH 7.5 et acétate pH 5.8. Les constantes de vitesse bimoléculaires d'extinction varient suivant la nature des ions lanthanides et sont comprises entre 0.9× 109 et 24.4×109 M-1s-1 en tampon HEPES, et 1.8×109 et 20.7×109 en tampon acétate et entre 2.0×109 et 22×109 M-1s-1 en milieu aqueux non tamponné. Un mécanisme comprenant un processus de croisement intersystème singulet-triplet induit par les ions lanthanides est proposé. Les constantes de vitesse de croisement intersystéme induit (kiscind) varient entre 2.0×107 et 4.7×107 M-1s-1. En milieu aqueux, les valeurs de kiscind se corrèlent bien avec la masse molaire des ions lanthanides étudiés.

  5. Langage, normes et repertoire en milieu urbain africain: L'indoubill (Language, Norms, and Repertoire in the African Urban Milieu: Indoubill).

    ERIC Educational Resources Information Center

    Sesep, N'Sial Bal-Nsien

    A study explored, from a sociolinguistic perspective, the phenomenon of indoubill, patterns and usage of a special variety of Lingala, among a group of delinquent urban youth in Kinshasa (Zaire). It is proposed that: (1) at a particular moment in its social history, the community experienced sociocultural change that brought with it a special…

  6. A propos de quelques experiences de francais fonctionnel en milieu hispanaphone (A Commentary on Experiments in Functional French in a Spanish-Speaking Milieu)

    ERIC Educational Resources Information Center

    Baltzer, Francois

    1978-01-01

    A discussion of the adaptation of audiovisual methods to respond to various specific needs in Mexico City. Some of the topics discussed are: meeting needs of people involved in special fields, particularly science, technology and economics; and the use of television for functional French instruction. (AMH)

  7. [Methodology for evaluating the social cost of noise in an industrial milieu].

    PubMed

    Josserand, P; Chamonard, D

    1982-05-01

    The investments needed for the prevention of noise in industrial environment bring no apparent profit to the firms and are therefore often deferred or rejected. Yet noise costs money, but part of this cost is "externalized". This cost cannot be entirely measured in financial terms since it is much more a social cost. We used different methods to try to evaluate this social cost. Occupational deafness, which is a parital indicator, allowed us to calculate the financial cost of its "repair". The non-financial aspect has been approached in a psychosocial study whose main results are presented here. These approaches, if they were better studied and appropriately extended, should lead to a more realistic assessment of the social cost of this nuisance. In this context an accurate evaluation of the social cost of noise could socially and economically justify strategies for noise prevention whose components are now well-known.

  8. Un modele simple pour la migration de radionucleides par transport colloidal dans un milieu fracture

    NASA Astrophysics Data System (ADS)

    Castaing, R.

    1991-06-01

    The long-term safety of nuclear waste disposal in a deep geological repository depends essentially on the capacity of artificial and natural barriers to slow down the possible return of long-lived radionuclides to the biosphere. Mathematical models applied to various geological formations have been developed for describing the time and space evolution of the radioactivity released by the waste packages. Such a study was carried out in Sweden in the case of a spent-fuel disposal in granitic bedrock. The basic problem is that of the transport of dissolved radioactive substances by the ground water flowing slowly along fractures in the rock. Retention of the radionuclides by sorption on the fracture walls and matrix diffusion is found to reduce drastically the nuclide migration; the conclusion is that the radiological impact of the repository should be negligible at any time in the future. One of the essential points in these calculations is that the nuclides are transported for the major part in an aqueous solution. We consider here the hypothetical case where a significant part of the nuclides would be transported by stable aggregates or colloids, small enough to follow the groundwater flow. It is clear that the nuclide transport might be much faster in such conditions than in the case of a simple aqueous solution. The model represents jointly the transport of the two phases, the solute phase and the colloidal one, in a fissure with constant aperture; the colloids are supposed to dissolve immediately when the concentration of the solute drops below the solubility limit through sorption of the fracture walls and diffusion into the matrix. In two typical cases (linear sorption of the colloids or strong sorption with maximum exchange capacity), analytical solutions may be obtained for the transport of the nuclides along the fissure, at the cost of approximations whose validity is briefly discussed.

  9. The Differential Hormonal Milieu of Morning versus Evening May Have an Impact on Muscle Hypertrophic Potential

    PubMed Central

    Allen, Jeremy; Grosset, Jean-Francois

    2016-01-01

    Substantial gains in muscle strength and hypertrophy are clearly associated with the routine performance of resistance training. What is less evident is the optimal timing of the resistance training stimulus to elicit these significant functional and structural skeletal muscle changes. Therefore, this investigation determined the impact of a single bout of resistance training performed either in the morning or evening upon acute anabolic signalling (insulin-like growth factor-binding protein-3 (IGFBP-3), myogenic index and differentiation) and catabolic processes (cortisol). Twenty-four male participants (age 21.4±1.9yrs, mass 83.7±13.7kg) with no sustained resistance training experience were allocated to a resistance exercise group (REP). Sixteen of the 24 participants were randomly selected to perform an additional non-exercising control group (CP) protocol. REP performed two bouts of resistance exercise (80% 1RM) in the morning (AM: 0800 hrs) and evening (PM: 1800 hrs), with the sessions separated by a minimum of 72 hours. Venous blood was collected immediately prior to, and 5 min after, each resistance exercise and control sessions. Serum cortisol and IGFBP-3 levels, myogenic index, myotube width, were determined at each sampling period. All data are reported as mean ± SEM, statistical significance was set at P≤0.05. As expected a significant reduction in evening cortisol concentration was observed at pre (AM: 98.4±10.5, PM: 49.8±4.4 ng/ml, P<0.001) and post (AM: 98.0±9.0, PM: 52.7±6.0 ng/ml, P<0.001) exercise. Interestingly, individual cortisol differences pre vs post exercise indicate a time-of-day effect (AM difference: -2±2.6%, PM difference: 14.0±6.7%, P = 0.03). A time-of-day related elevation in serum IGFBP-3 (AM: 3274.9 ± 345.2, PM: 3605.1 ± 367.5, p = 0.032) was also evident. Pre exercise myogenic index (AM: 8.0±0.6%, PM: 16.8±1.1%) and myotube width (AM: 48.0±3.0, PM: 71.6±1.9 μm) were significantly elevated (P<0.001) in the evening. Post exercise myogenic index was greater AM (11.5±1.6%) compared with PM (4.6±0.9%). No difference was observed in myotube width (AM: 48.5±1.5, PM: 47.8±1.8 μm) (P>0.05). Timing of resistance training regimen in the evening appears to augment some markers of hypertrophic potential, with elevated IGFBP-3, suppressed cortisol and a superior cellular environment. Further investigation, to further elucidate the time course of peak anabolic signalling in morning vs evening training conditions, are timely. PMID:27583459

  10. The Antikythera Mechanism: The oldest mechanical universe in its scientific milieu

    NASA Astrophysics Data System (ADS)

    Moussas, Xenophon

    2011-06-01

    In this review the oldest known advanced astronomical instrument and dedicated analogue computer is presented, in context. The Antikythera Mechanism a mysterious device, assumed to be ahead of its time, probably made around 150 to 100 BCE, has been found in a 1st century BCE shipwreck near the island of Antikythera in a huge ship full of Greek treasures that were on their way to Rome. The Antikythera Mechanism is a clock-like device made of bronze gears, which looks much more advanced than its contemporary technological achievements. It is based on mathematics attributed to the Hipparchus and possibly carries knowledge and tradition that goes back to Archimedes, who according to ancient texts constructed several automata, including astronomical devices, a mechanical planetarium and a celestial sphere. The Antikythera Mechanism probably had a beautiful and expensive box; looking possibly like a very elaborate miniature Greek Temple, perhaps decorated with golden ornaments, of an elegant Hellenistic style, even perhaps with automatic statuettes, `daemons', functioning as pointers that performed some of its operations. Made out of appropriately tailored trains of gears that enable to perform specialised calculations, the mechanism carries concentric scales and pointers, in one side showing the position of the Sun in the ecliptic and the sky, possibly giving the time, hour of the day or night, like a clock. The position of the Moon and its phase is also shown during the month. On the other side of the Mechanism, having probably the size of a box (main part 32×20×6 cm), are two large spiral scales with two pointers showing the time in two different very long calendars, the first one concerning the eclipses, and lasting 18 years 11 days and 8 hours, the Saros period, repeating the solar and lunar eclipses, and enabling their prediction, and the 19 year cycle of Meton, that is the period the Moon reappears in the same place of the sky, with the same phase. An additional four-year dial shows the year of all Greek Festivities, the so-called `games' (Olympic, Pythian, Isthmian etc). Two additional dials give the Exeligmos, the 54 year and 34 day cycle, which provides a more accurate prediction of eclipses. It is possible that the Mechanism was also equipped with a planetary show display, as three of the planets and their motion (stationary points) are mentioned many times in the manual of the instrument, so it was also a planetarium. From the manual we have hints that the mechanism was probably also an observational instrument, as having instructions concerning a viewfinder and possibly how to orient the viewfinder to pass a sunbeam through it, probably measuring the altitude of the Sun. There are fragmented sentences that probably give instructions on how to move the pointers to set the position of the Sun, the Moon and the planets in their initial places in the ecliptic, on a specific day, or how to measure angular distances between two celestial bodies or their coordinates. This mechanism is definitely not the first one of its kind. The fact that it is accompanied with instructions means that the constructor had in its mind to be used by somebody else and one posits that he made at least another similar instrument.

  11. Toll-like receptor 2 modulates the proinflammatory milieu in Staphylococcus aureus-induced brain abscess.

    PubMed

    Kielian, Tammy; Haney, Anessa; Mayes, Patrick M; Garg, Sarita; Esen, Nilufer

    2005-11-01

    Toll-like receptor 2 (TLR2) is a pattern recognition receptor (PRR) that plays an important role in innate immune recognition of conserved structural motifs on a wide array of pathogens, including Staphylococcus aureus. To ascertain the functional significance of TLR2 in the context of central nervous system (CNS) parenchymal infection, we evaluated the pathogenesis of S. aureus-induced experimental brain abscess in TLR2 knockout (KO) and wild-type (WT) mice. The expression of several proinflammatory mediators, including inducible nitric oxide synthase, tumor necrosis factor alpha, and macrophage inflammatory protein-2, was significantly attenuated in brain abscesses of TLR2 KO mice compared to WT mice during the acute phase of infection. Conversely, interleukin-17 (IL-17), a cytokine produced by activated and memory T cells, was significantly elevated in lesions of TLR2 KO mice, suggesting an association between innate and adaptive immunity in brain abscess. Despite these differences, brain abscess severity in TLR2 KO and WT animals was similar, with comparable mortality rates, bacterial titers, and blood-brain barrier permeability, implying a role for alternative PRRs. Expression of the phagocytic PRRs macrophage scavenger receptor type AI/AII and lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) was increased in brain abscesses of both TLR2 KO and WT mice compared to uninfected animals. However, LOX-1 induction in brain abscesses of TLR2 KO mice was significantly attenuated compared to WT animals, revealing that the TLR2-dependent signal(s) influence LOX-1 expression. Collectively, these findings reveal the complex nature of gram-positive bacterial recognition in the CNS which occurs, in part, through engagement of TLR2 and highlight the importance of receptor redundancy for S. aureus detection in the CNS.

  12. Increasing Math Milieu Teaching by Varying Levels of Consultation Support: An Example of Analyzing Intervention Strength

    ERIC Educational Resources Information Center

    Marsicano, Richard T.; Morrison, Julie Q.; Moomaw, Sally C.; Fite, Nathan M.; Kluesener, Courtney M.

    2015-01-01

    The current study used a single-case design to examine two performance feedback conditions varying in intensity on the frequency of naturalistic math instruction in preschool classrooms during non-instructional times (transition, lunch, free play). Three Head Start teachers received professional development that combined information on four…

  13. The Intelligence Phenomenon in a New Democratic Milieu. Romania-A Case Study

    DTIC Science & Technology

    2006-03-01

    THIS PAGE INTENTIONALLY LEFT BLANK xiii ACKNOWLEDGMENTS I wish to express my gratitude to everyone who contributed to...Thomas Bruneau, “Civil-Military Relations in Latin America: The Hedgehog and the Fox Revisited” in Revista Fuerzas Armadas y Sociedad , (Santiago de...Armadas y Sociedad no. 1 (Santiago de Chile: 2005). –––. “Controlling Intelligence in New Democracies,” in Loch Johnson and James Wirtz, eds. Strategic

  14. Remote Sensing of the Propagation Environment (La Teledetection du Milieu de Propagation)

    DTIC Science & Technology

    1992-02-01

    Defence MStl- Research sand Developinent Dept. ARGE .06650 Ainkara TULUNAY Prof. Dr E. TULUNAY. Turkey Middle Eaist Techinical University .06531...F AD-A247 934 -~ ~ 1 1ItII41fi1, _________________AGARD-CP-502 A.GARD SADVISORY GROUP FOR A.ROSPACE RESEARCH & DEVE.OPMENT 0 - 4, 7 RUE ANCELLE 92200...potential; - Rendering scientific and technical assmlanc, as requested. to other NATO bodies and to member nations in connection with research and

  15. Instabilité non linéaire dans un milieu en expansion

    NASA Astrophysics Data System (ADS)

    Henon, Florent; Pavlov, Vadim

    2006-04-01

    We consider nonlinear acoustical phenomena, explosive instabilities and a formation of localized structures in nonstationary environment. An example of such a medium is our Universe in expansion considered as a fluid submissive to a gravitational self-concorded force field and governed by the classical hydrodynamics equations. We show that the taking into account of the nonlinear effects allow us to understand the causes of the appearance of the specific nonlinear instability, which is calling explosive instability. This type of instability is more fast, ˜ln[(] for density fluctuation, that the habitual instability (exponential, ˜e): at the end of a finite time, all spatial inhomogeneity of the initials conditions lead to a formation of singularities in the fields. This phenomena will be appear if certains conditions for the initials amplitudes and wavelengths of the fluctuations are observed. To cite this article: F. Henon, V. Pavlov, C. R. Mecanique 334 (2006).

  16. The Inflammatory Milieu Permits Metastasis in Pregnancy-Associated Breast Cancer

    DTIC Science & Technology

    2008-07-01

    leucocyte infiltration (Figure 1) and CD68, as a measure of macrophage content (Figure 2) in pregnant, lactating, involuting and fully regressed...the common leucocyte antigen, by IHC. Using a computer assisted quantification program, the percent positive cells were evaluated in ~10 fields per... leucocytes (CD45 positive cells) transiently infiltrate the gland during involution. 4. Demonstration that CD68 positive cells are increased during

  17. Children with Anxiety Disorders: Use of a Cognitive Behavioral Therapy Model within a Social Milieu

    ERIC Educational Resources Information Center

    Kearny, Regina; Pawlukewicz, Justine; Guardino, Mary

    2014-01-01

    Because anxiety is the most common mental health disorder diagnosed in children, early intervention is crucial for fundamental coping. Although cognitive-behavioral therapy (CBT) is the preferred treatment method for this affective disorder, instruction for children needs to be specific for them to successfully acquire and implement essential CBT…

  18. The Relationship between Teacher Language Use in Enhanced Milieu Teaching Sessions and Child Language Outcomes

    ERIC Educational Resources Information Center

    McLeod, Jennifer Ragan Henderson

    2010-01-01

    Research indicates that linguistic input from teachers may affect child vocabulary development in preschool and beyond (Dickinson & Tabors, 2001). Currently, there is little research on the relationship between specific teacher language use in individual interactions on child language outcomes for preschool children at risk for academic delays.…

  19. Increasing Social Interaction Using Prelinguistic Milieu Teaching with Nonverbal School-Age Children with Autism

    ERIC Educational Resources Information Center

    Franco, Jessica H.; Davis, Barbara L.; Davis, John L.

    2013-01-01

    Purpose: Children with autism display marked deficits in initiating and maintaining social interaction. Intervention using play routines can create a framework for developing and maintaining social interaction between these children and their communication partners. Method: Six nonverbal 5- to 8-year-olds with autism were taught to engage in…

  20. Student Teachers' General and Content-Specific Pedagogical Development within a Mathematics Milieu

    ERIC Educational Resources Information Center

    Piccolo, Diana L.; Capraro, Mary Margaret; Capraro, Robert M.

    2010-01-01

    Fourteen elementary and 6 middle level student teachers were observed and interviewed throughout their initial field placement teaching experience. The Classroom Observation and Performance Assessment for Teachers-Revised (COPAT-R) observation instrument and semistructured interviews were used to compare general and content-specific pedagogical…

  1. Effects of Polymer Hydrophobicity on Protein Structure and Aggregation Kinetics in Crowded Milieu.

    PubMed

    Breydo, Leonid; Sales, Amanda E; Frege, Telma; Howell, Mark C; Zaslavsky, Boris Y; Uversky, Vladimir N

    2015-05-19

    We examined the effects of water-soluble polymers of various degrees of hydrophobicity on the folding and aggregation of proteins. The polymers we chose were polyethylene glycol (PEG) and UCON (1:1 copolymer of ethylene glycol and propylene glycol). The presence of additional methyl groups in UCON makes it more hydrophobic than PEG. Our earlier analysis revealed that similarly sized PEG and UCON produced different changes in the solvent properties of water in their solutions and induced morphologically different α-synuclein aggregates [Ferreira, L. A., et al. (2015) Role of solvent properties of aqueous media in macromolecular crowding effects. J. Biomol. Struct. Dyn., in press]. To improve our understanding of molecular mechanisms defining behavior of proteins in a crowded environment, we tested the effects of these polymers on secondary and tertiary structure and aromatic residue solvent accessibility of 10 proteins [five folded proteins, two hybrid proteins; i.e., protein containing ordered and disordered domains, and three intrinsically disordered proteins (IDPs)] and on the aggregation kinetics of insulin and α-synuclein. We found that effects of both polymers on secondary and tertiary structures of folded and hybrid proteins were rather limited with slight unfolding observed in some cases. Solvent accessibility of aromatic residues was significantly increased for the majority of the studied proteins in the presence of UCON but not PEG. PEG also accelerated the aggregation of protein into amyloid fibrils, whereas UCON promoted aggregation to amyloid oligomers instead. These results indicate that even a relatively small change in polymer structure leads to a significant change in the effect of this polymer on protein folding and aggregation. This is an indication that protein folding and especially aggregation are highly sensitive to the presence of other macromolecules, and an excluded volume effect is insufficient to describe their effect.

  2. Age-associated changes in cardiovascular structure and function: a fertile milieu for future disease.

    PubMed

    Fleg, Jerome L; Strait, James

    2012-09-01

    Important changes occur in the cardiovascular system with advancing age, even in apparently healthy individuals. Thickening and stiffening of the large arteries develop due to collagen and calcium deposition and loss of elastic fibers in the medial layer. These arterial changes cause systolic blood pressure to rise with age, while diastolic blood pressure generally declines after the sixth decade. In the left ventricle, modest concentric wall thickening occurs due to cellular hypertrophy, but cavity size does not change. Although left ventricular systolic function is preserved across the age span, early diastolic filling rate declines 30-50% between the third and ninth decades. Conversely, an age-associated increase in late diastolic filling due to atrial contraction preserves end-diastolic volume. Aerobic exercise capacity declines approximately 10% per decade in cross-sectional studies; in longitudinal studies, however, this decline is accelerated in the elderly. Reductions in peak heart rate and peripheral oxygen utilization but not stroke volume appear to mediate the age-associated decline in aerobic capacity. Deficits in both cardiac β-adrenergic receptor density and in the efficiency of postsynaptic β-adrenergic signaling contribute significantly to the reduced cardiovascular performance during exercise in older adults. Although these cardiovascular aging changes are considered "normative", they lower the threshold for the development of cardiovascular disease, which affects the majority of older adults.

  3. Teledetection passive et processus decisionnel a reference spatiale: Application a l'aquaculture en milieu marin

    NASA Astrophysics Data System (ADS)

    Habbane, Mohamed

    L'objectif de cette etude est d'elaborer un processus decisionnel a reference spatiale (PDRS) pour la mariculture. Le PDRS est applique aux eaux cotieres de la baie des Chaleurs, dans le golfe du Saint-Laurent (Canada). Une carte preliminaire regionale d'indices du potentiel maricole, d'une limite de resolution spatiale de 1 kmsp2, est produite avec des parametres du niveau 1. Ces parametres englobent la temperature de l'eau de surface, extraite des images AVHRR, la salinite, les courants ainsi que les pigments chlorophylliens, quantifies a l'aide de mesures in situ. Les images AVHRR, prises en 1994, ont ete utiliees comme reference primaire pour selectionner des aires pouvant supporter une activite maricole sur la cote nord de la baie des Chaleurs. La temperature de surface extraite de ces images permet une analyse mesoechelle a la fois qualitative et quantitative des processus cotiers observes pendant la periode d'acquisition des donnees. Les autres donnees, soit la salinite, les courants et les concentrations en pigments chlorophylliens, sont analysees de facon a identifier la variabilite spatio-temporelle des caracteristiques des eaux de surface. L'ensemble des informations permet de produire une carte preliminaire regionale d'indices du potentiel maricole de la partie centrale de la baie des Chaleurs. Selon cet indice (defini entre 0 et 1), le secteur de potentiel aquicole de 0,5 a 0,75 s'etend sur une superficie d'environ 300 kmsp2. La localisation de cette aire potentielle est en accord avec les fortes concentrations en pigments chlrophylliens, presentant des conditions environnementales ideales a une haute productivite biologique. Par la suite la carte preliminaire est modifiee en tenant compte des parametres du niveau 2. Ces parametres sont la geomorphologie littorale, la bathymetrie, les sediments en suspension, les vents, les vagues, le debit d'eau douce, la glace marine, le carbone organique dissous, les aires de peche et les sources de pollution. Ces parametres sont compares deux a deux par rapport a la carte preliminaire regionale d'indices du potentiel maricole pour determiner leur poids relatif. La carte finale produite avec ces parametres du niveau 2 presente un secteur ou les indices du potentiel maricole sont de 0,5 a 0,75. Ce secteur longe la cote et epouse les isobathes de 10 a 30 m de profondeur. L'effet de la profondeur d'eau semble avoir jouer un role important. Le secteur de potentiel maricole de 0,25 a 0,5 est toujours present et couvre une superficie d'environ 426 kmsp2. L'etude necessitera toujours un suivi des conditions environnementales prevalant dans la region. Ce suivi peut etre effectue a l'aide d'un outil de vision aerospatiale (capteurs de teledetection) et d'analyse spatio-temporelle (SIG-PDRS). (Abstract shortened by UMI.)

  4. Changes in Personality Disorder Traits Following 2 Years of Treatment in a Secure Therapeutic Community Milieu

    ERIC Educational Resources Information Center

    Morrissey, Catrin; Taylor, Jon

    2014-01-01

    Therapeutic community treatment models have not previously been applied to forensic patients with mild intellectual disabilities (IDs) with a comorbid diagnosis of personality disorder. Thirteen patients with mild IDs were allocated to a unit within a high secure psychiatric service operating a model of treatment based on the principles and…

  5. Homeostasis, the Milieu Intérieur, and the Wisdom of the Nephron

    PubMed Central

    Zeidel, Mark L.

    2014-01-01

    The concept of homeostasis has been inextricably linked to the function of the kidneys for more than a century when it was recognized that the kidneys had the ability to maintain the “internal milieu” and allow organisms the “physiologic freedom” to move into varying environments and take in varying diets and fluids. Early ingenious, albeit rudimentary, experiments unlocked a wealth of secrets on the mechanisms involved in the formation of urine and renal handling of the gamut of electrolytes, as well as that of water, acid, and protein. Recent scientific advances have confirmed these prescient postulates such that the modern clinician is the beneficiary of a rich understanding of the nephron and the kidney’s critical role in homeostasis down to the molecular level. This review summarizes those early achievements and provides a framework and introduction for the new CJASN series on renal physiology. PMID:24789550

  6. Strategies to Address Infection Prevention and Treatment in the Reduced Inflammatory Milieu of Irrigated Open Wound

    DTIC Science & Technology

    2012-10-01

    debridement, however, removes the body’s first healing response, such as fracture hematoma . We implemented an irrigated radius defect model intended...13. SUPPLEMENTARY NOTES 14. ABSTRACT Open fractures require irrigation and debridement to prevent potential infection. Irrigation and...to represent the open fracture setting with bone loss. We evaluated feasibility to investigate the role of platelet rich plasma (PRP) to restore

  7. 3D Modelling of Urban Terrain (Modelisation 3D de milieu urbain)

    DTIC Science & Technology

    2011-09-01

    Automatic Target Recognition (ATR) From a list of targets location output by ATD algorithms, ATR algorithms output possible target classification with...Assessment; and c) Automatic Target Detection and Recognition . 2.1 MISSION PLANNING/TRAINING Urban mission planning requires taking into consideration...also made to elaborate wall compensation strategies and to develop tools for target detection and classification [40]. 3.2.2 Estimating Distances

  8. Site-directed mutagenesis of an alkaline phytase: influencing specificity, activity and stability in acidic milieu.

    PubMed

    Tran, Thuy T; Mamo, Gashaw; Búxo, Laura; Le, Nhi N; Gaber, Yasser; Mattiasson, Bo; Hatti-Kaul, Rajni

    2011-07-10

    Site-directed mutagenesis of a thermostable alkaline phytase from Bacillus sp. MD2 was performed with an aim to increase its specific activity and activity and stability in an acidic environment. The mutation sites are distributed on the catalytic surface of the enzyme (P257R, E180N, E229V and S283R) and in the active site (K77R, K179R and E227S). Selection of the residues was based on the idea that acid active phytases are more positively charged around their catalytic surfaces. Thus, a decrease in the content of negatively charged residues or an increase in the positive charges in the catalytic region of an alkaline phytase was assumed to influence the enzyme activity and stability at low pH. Moreover, widening of the substrate-binding pocket is expected to improve the hydrolysis of substrates that are not efficiently hydrolysed by wild type alkaline phytase. Analysis of the phytase variants revealed that E229V and S283R mutants increased the specific activity by about 19% and 13%, respectively. Mutation of the active site residues K77R and K179R led to severe reduction in the specific activity of the enzyme. Analysis of the phytase mutant-phytate complexes revealed increase in hydrogen bonding between the enzyme and the substrate, which might retard the release of the product, resulting in decreased activity. On the other hand, the double mutant (K77R-K179R) phytase showed higher stability at low pH (pH 2.6-3.0). The E227S variant was optimally active at pH 5.5 (in contrast to the wild type enzyme that had an optimum pH of 6) and it exhibited higher stability in acidic condition. This mutant phytase, displayed over 80% of its initial activity after 3h incubation at pH 2.6 while the wild type phytase retained only about 40% of its original activity. Moreover, the relative activity of this mutant phytase on calcium phytate, sodium pyrophosphate and p-nitro phenyl phosphate was higher than that of the wild type phytase.

  9. Targeting the Peroxisome Proliferator-Activated Receptor-γ to Counter the Inflammatory Milieu in Obesity

    PubMed Central

    Corzo, Cesar

    2013-01-01

    Adipose tissue, which was once viewed as a simple organ for storage of triglycerides, is now considered an important endocrine organ. Abnormal adipose tissue mass is associated with defects in endocrine and metabolic functions which are the underlying causes of the metabolic syndrome. Many adipokines, hormones secreted by adipose tissue, regulate cells from the immune system. Interestingly, most of these adipokines are proinflammatory mediators, which increase dramatically in the obese state and are believed to be involved in the pathogenesis of insulin resistance. Drugs that target peroxisome proliferator-activated receptor-γ have been shown to possess anti-inflammatory effects in animal models of diabetes. These findings, and the link between inflammation and the metabolic syndrome, will be reviewed here. PMID:24404510

  10. Endocrine milieu and erectile dysfunction: is oestradiol-testosterone imbalance, a risk factor in the elderly?

    PubMed

    Srilatha, Balasubramanian; Adaikan, P Ganesan

    2011-07-01

    Oestrogens are not exclusive to the female gender but occur in moderate circulating levels of 25-70 pg ml⁻¹ in men, compared to 44-153 pg ml⁻¹ in women. Arising from aromatisation of testosterone (T), oestrogen is considered to have many opposing physiological functions and the progressive T decline in the aging male is associated with relative and/or absolute increase in serum oestradiol (E₂). Sexual disinterest and erectile dysfunction (ED) in the elderly may well be due to pathophysiological E₂-T imbalance; the altered hormonal ratio may also explain the higher incidence of ED in hyperestrogenism or following exposure to environmental/plant oestrogens.

  11. Morphologic responses of the mouse ovarian surface epithelium to ovulation and steroid hormonal milieu.

    PubMed

    Gotfredson, Garry S; Murdoch, William J

    2007-02-01

    Ovarian cancer of surface epithelial origin is an ovulation- and endocrine-related disease. It appears that a cell transformed by genotoxins generated at follicular rupture is propagated during postovulatory wound repair. A consequent steroid hormonal imbalance favoring the mitogenic estrogens is a prospective predisposing factor in ovarian neoplasia. Protection against epithelial ovarian cancer is conferred by progesterone. The objective of this study was to characterize the acute effects of ovulation and steroid hormonal exposure on morphologic responses of surface epithelial cells of mouse ovaries. Follicular development and ovulation were induced in immature animals with equine and human (=Day 0) choriogonadotropins, respectively. On Day 2 (approximately 36 hrs after ovulation), surface epithelial classifications presented in histologic sections were altered from simple (single-layered) squamous and cuboidal toward stratification; this trend was reversed (i.e., reverted to the control status) on Days 4-8. Shifts in the ovarian epithelium from simple to stratified were accentuated following postovulatory (Days 1-8) treatment with estradiol. Surface epithelia of ovaries obtained after 1 week of progesterone administration were exclusively of a simple phenotype. We conclude that the proliferative/procarcinogenic reaction of the ovarian surface epithelium to ovulation is exacerbated by estrogen and counteracted by progesterone.

  12. Altered Intracellular Milieu of ADAR2-Deficient Motor Neurons in Amyotrophic Lateral Sclerosis.

    PubMed

    Yamashita, Takenari; Akamatsu, Megumi; Kwak, Shin

    2017-02-08

    Transactive response DNA-binding protein (TDP-43) pathology, and failure of A-to-I conversion (RNA editing) at the glutamine/arginine (Q/R) site of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor subunit GluA2, are etiology-linked molecular abnormalities that concomitantly occur in the motor neurons of most patients with amyotrophic lateral sclerosis (ALS). Adenosine deaminase acting on RNA 2 (ADAR2) specifically catalyzes GluA2 Q/R site-RNA editing. Furthermore, conditional ADAR2 knockout mice (AR2) exhibit a progressive ALS phenotype with TDP-43 pathology in the motor neurons, which is the most reliable pathological marker of ALS. Therefore, the evidence indicates that ADAR2 downregulation is a causative factor in ALS, and AR2 mice exhibit causative molecular changes that occur in ALS. We discuss the contributors to ADAR2 downregulation and TDP-43 pathology in AR2 mouse motor neurons. We describe mechanisms of exaggerated Ca(2+) influx amelioration via AMPA receptors, which is neuroprotective in ADAR2-deficient motor neurons with normalization of TDP-43 pathology in AR2 mice. Development of drugs to treat diseases requires appropriate animal models and a sensitive method of evaluating efficacy. Therefore, normalization of disrupted intracellular environments resulting from ADAR2 downregulation may be a therapeutic target for ALS. We discuss the development of targeted therapy for ALS using the AR2 mouse model.

  13. Urban effluent discharges as causes of public and environmental health concerns in South Africa's aquatic milieu.

    PubMed

    Sibanda, Timothy; Selvarajan, Ramganesh; Tekere, Memory

    2015-12-01

    The water quality in South Africa's river systems is rapidly deteriorating as a consequence of increased discharge of wastewater effluents. The natural ability of rivers and reservoirs to trap toxic chemicals and nutrients in their sediments enables these systems to accumulate contaminants, altering the natural balance in environmental water quality, thereby raising a plethora of public and environmental health concerns. Impaired water quality has been linked to an array of problems in South Africa including massive fish mortalities, altered habitat template leading to the thinning of riverine macroinvertebrate diversity, shifts in microbial community structures with drastic ecological consequences and evolvement of antibiotic resistance genes that, under natural conditions, can be transferred to waterborne pathogens. Urban wastewater discharge has also been implicated in increased bioaccumulation of metals in edible plant parts, elevated concentrations of endocrine-disrupting compounds (EDCs), which are blamed for reduced fertility and increased cancer risk, excessive growth of toxic cyanobacteria and an increase in concentrations of pathogenic microorganisms which constitute a potential health threat to humans. However, despite the ecotoxicological hazards posed by wastewater effluents, ecotoxicological studies are currently underutilised in South African aquatic ecosystem assessments, and where they have been done, the observation is that ecotoxicological studies are mostly experimental and restricted to small study areas. More research is still needed to fully assess especially the ecotoxicological consequences of surface water pollution by urban wastewater effluents in South Africa. A review of the effects of urban effluent discharges that include domestic effluent mixed with industrial effluent and/or urban stormwater run-off is hereby presented.

  14. [Vitalism and mechanism: their meanings in the milieu of the 17th and 18th centuries].

    PubMed

    Hwang, S I

    1993-01-01

    The views on the life in the early modern period (the 17th and 18th centuries) with their socio-cultural backgrounds and their meanings at that time were discussed in this paper. Those views discussed here were the dualistic, mechanistic one of Rene Descartes (1596-1650), the animistic, vitalistic one of Georg Ernst Stahl (1660-1734), and the monistic, mechanistic one of Julien Offray de la Mettrie (1709-1751). Author stressed that the processes of their view formation were influenced by the wide range of the various political and religious factors as well as the scientific, medical facts and opinions at that time, and that not only the contents of the views but also their historical contexts should be pursued in the study on the medical thoughts.

  15. Learning Experiences of Gifted Young String Players in the Taiwan Milieu

    ERIC Educational Resources Information Center

    Liu, Chia-Hui

    2008-01-01

    The purpose of this study was to investigate the development of the learning experiences of gifted young string players in Taiwan. Nine musicians under the age of 40, who had been accepted into music programs for the gifted, were invited to discuss their experiences and the development of their careers. Thorough interviews were conducted and then…

  16. Tissue Engineering Approaches to Modulate the Inflammatory Milieu following Spinal Cord Injury.

    PubMed

    Dumont, Courtney M; Margul, Daniel J; Shea, Lonnie D

    2016-01-01

    Tissue engineering strategies have shown promise in promoting healing and regeneration after spinal cord injury (SCI); however, these strategies are limited by inflammation and the immune response. Infiltration of cells of the innate and adaptive immune responses and the inflammation that follows cause secondary damage adjacent to the injury, increased scarring, and a potently inhibitory environment for the regeneration of damaged neurons. While the inflammation that ensues is typically associated with limited regeneration, the immune response is a crucial element in the closing of the blood-brain barrier, minimizing the spread of injury, and initiating healing. This review summarizes the strategies that have been developed to modulate the immune response towards an anti-inflammatory environment that is permissive to the regeneration of neurons, glia, and parenchyma. We focus on the use of biomaterials, biologically active molecules, gene therapy, nanoparticles, and stem cells to modulate the immune response, and illustrate concepts for future therapies. Current clinical treatments for SCI are limited to systemic hypothermia or methylprednisolone, which both act by systemically mitigating the effects of immune response but have marginal efficacy. Herein, we discuss emerging research strategies to further enhance these clinical treatments by directly targeting specific aspects of the immune response.

  17. Bone Marrow Stem/Progenitor Cells Attenuate the Inflammatory Milieu Following Substitution Urethroplasty

    PubMed Central

    Liu, Joceline S.; Bury, Matthew I.; Fuller, Natalie J.; Sturm, Renea M.; Ahmad, Nida; Sharma, Arun K.

    2016-01-01

    Substitution urethroplasty for the treatment of male stricture disease is often accompanied by subsequent tissue fibrosis and secondary stricture formation. Patients with pre-existing morbidities are often at increased risk of urethral stricture recurrence brought upon in-part by delayed vascularization accompanied by overactive inflammatory responses following surgery. Within the context of this study, we demonstrate the functional utility of a cell/scaffold composite graft comprised of human bone marrow-derived mesenchymal stem cells (MSC) combined with CD34+ hematopoietic stem/progenitor cells (HSPC) to modulate inflammation and wound healing in a rodent model of substitution urethroplasty. Composite grafts demonstrated potent anti-inflammatory effects with regards to tissue macrophage and neutrophil density following urethral tissue analyses. This was accompanied by a significant reduction in pro-inflammatory cytokines TNFα and IL-1β and further resulted in an earlier transition to tissue remodeling and maturation with a shift in collagen type III to I. Grafted animals demonstrated a progressive maturation and increase in vessel size compared to control animals. Overall, MSC/CD34+ HSPC composite grafts reduce inflammation, enhance an earlier transition to wound remodeling and maturation concurrently increasing neovascularization in the periurethral tissue. We demonstrate the feasibility and efficacy of a stem cell-seeded synthetic graft in a rodent substitution urethroplasty model. PMID:27762304

  18. Stress among Secondary School Teachers in Ebonyi State, Nigeria: Suggested Interventions in the Worksite Milieu

    ERIC Educational Resources Information Center

    Nwimo, Ignatius O.; Onwunaka, Chinagorom

    2015-01-01

    The aim of the study was to determine the level of stress experienced by secondary school teachers in Ebonyi State. The dimensions of stress studied included physical stress, mental stress, emotional stress and social stress. The study adopted the cross-sectional survey design using a sample of 660 (male 259, female 401) teachers randomly drawn…

  19. Urinary neopterin does not reflect the local antitumor immune milieu in ovarian cancer.

    PubMed

    Zeimet, Alain G; Reimer, Daniel; Schwentner, Lukas; Fuchs, Dietmar; Wolf, Dominik; Fuith, Lothar C; Fiegl, Heidi; Doppler, Wolfgang; Concin, Nicole; Daxenbichler, Günter; Marth, Christian

    2010-12-01

    The main objective of the present investigation was to study the urinary neopterin excretion in the context of the activation of the adaptive cellular immune system at the tumor site. For this purpose, we compared pre-treatment urinary neopterin levels measured in 92 ovarian cancer patients, with intratumoral levels of mRNA transcripts from factors either involved in the adaptive antitumor immune defense (CD3, IFN-γ, IRF-1, IRF-2, SOCS1 and iNOS) or immune tolerance (FoxP3). This study did not reveal an association between urinary neopterin and one of these investigated "on tumor site transcripts". From all the factors reflecting the magnitude of the local adaptive antitumor response, intratumoral IRF-1 expression above the edge of the 25th percentile was found to predict most reliably favorable progression-free (median 34 months vs. 10 months; p < 0.001) and overall (median 52 months vs. 16 months; p < 0.001) survival. In contrast, pre-treatment urinary neopterin excretion above 275 μmol/mol creatinine, which indicates an unspecific activation of the innate immune system, was associated with a very poor overall survival with a median of only 11 months when compared with a median overall survival of 40 months in patients with lower urinary neopterin excretion (p = 0.021). Interestingly, the considerable survival benefit in patients with high IRF-1-expressing cancers was completely abrogated as well for progression-free as for overall survival when urinary neopterin concentrations were found to be concomitantly elevated. These findings demonstrate that in ovarian carcinomas the unspecific "cancer-related inflammation" contributes to a significant subversion of the adaptive antitumor immune defense mounted at the tumor site.

  20. Premetastatic milieu explained by TLR4 agonist-mediated homeostatic inflammation.

    PubMed

    Maru, Yoshiro

    2010-03-01

    Accumulating evidence suggests that Toll-like receptor 4 (TLR4), a sensor for danger signals, is expressed not only in immune cells, but also in resident epithelial cells, and appears to participate in tissue homeostasis. To explain the premetastatic microenvironment created by the newly discovered endogenous TLR4 ligands, I propose a hypothesis of homeostatic inflammation that includes the classical danger hypothesis.

  1. Etiologie Rare de Sinusites Nosocomiales en Milieu de Reanimation - A Propos d'une Observation

    PubMed Central

    Messadi, A.A.; Oueslati, S.; Thabet, L.; Bousselmi, K.; Menif, E.

    2006-01-01

    Summary Les sinusites nosocomiales ne sont pas rares en réanimation. Elles surviennent en général dans les suites d'une intubation nasotrachéale voire même orotrachéale. Le tubage gastrique peut être à lui seul à l'origine d'une sinusite nosocomiale. Nous rapportons le cas d'une patiente hospitalisée qui a été victime de brûlures étendues chez qui la sonde nasogastrique a été à l'origine d'une pansinusite dont l'issue a été fatale. PMID:21991055

  2. [How is breast-feeding valued in the urban and semi-urban Central African milieu?].

    PubMed

    Sépou, A; Yanza, M C; Nguémbi, E; Tekpa, G; Ngbalè, R

    2001-01-01

    Efforts have been made for several years to promote the use of breast milk by mothers. This is important for mothers in developing countries faced with economic problems, especially for those tempted by milk substitutes. Fortunately, BF (breast feeding) is used by a majority of women in these developing countries, its practice is often influenced by an early introduction of supplements. Why this early supplementation? In order to answer this question we performed this study, a transversal survey of mothers in neonatal period in a regional town and the capital of Central Africa. The compilation of data of this seven month study, carried out in four maternities and nine SMI centers, was carried out from a pre-established questionnaire. This allowed us to obtain the following results. We interrogated 734 mothers of newborn babies aged between 14 and 45 years, including 534 in Bangui and 200 in Bossangoa. Breast feeding was chosen by 96.5% of mothers, however exclusive breast feeding was only carried out by 17% of mothers. Feeding on demand was widely spread both in Bangui (92.7%) and in Bossangoa (92%). Breast milk was the first food received at birth by 84.5% of newborn babies. At the neonatal period, water supplementation was more frequent (78.1%, including 23% at birth) than that of solid or semi-liquid food (6.2%). The value given to breast milk was just nutritional, its other virtues were not well known. Conclusion, In breast mil remains the food of choice in our country. However, its practice suffers from much ignorance. An effort should be made to heighten awareness and give milk its due worth.

  3. Immunology by numbers: quantitation of antigen presentation completes the quantitative milieu of systems immunology!

    PubMed

    Purcell, Anthony W; Croft, Nathan P; Tscharke, David C

    2016-06-01

    We review approaches to quantitate antigen presentation using a variety of biological and biochemical readouts and highlight the emerging role of mass spectrometry (MS) in defining and quantifying MHC-bound peptides presented at the cell surface. The combination of high mass accuracy in the determination of the molecular weight of the intact peptide of interest and its signature pattern of fragmentation during tandem MS provide an unambiguous and definitive identification. This is in contrast to the potential receptor cross-reactivity towards closely related peptides and variable dose responsiveness seen in biological readouts. In addition, we gaze into the not too distant future where big data approaches in MS can be accommodated to quantify whole immunopeptidomes both in vitro and in vivo.

  4. Inflammatory milieu as an early marker of kidney injury in offspring rats from diabetic mothers.

    PubMed

    Correa-Costa, Matheus; Landgraf, Maristella A; Cavanal, Maria F; Semedo, Patricia; Vieira, Daniel A G; De Marco, Davi T K; Hirata, Aparecida E; Câmara, Niels O S; Gil, Frida Z

    2012-08-15

    The present study investigated the early presence of inflammatory response in renal tissue of young offspring from diabetic mothers. The effect of L-arginine (L-arg) supplementation was also investigated. The offspring was divided into four groups: group CO (controls); group DO (diabetic offspring); group CA (CO receiving 2% L-arg solution) and group DA (DO receiving the 2% L-arg solution). Glycemia, arterial pressure and renal function were evaluated; gene and protein expression of pro-inflammatory cytokines were also measured. Blood pressure levels were significantly increased in 2 and 6 month-old DO rats, whereas L-arg administration caused a significant decrease in the DA group, at both ages. DO rats showed a significantly blunted glycemic response to exogenous insulin. In 2 month-old DO animals, renal protein expression of pro-inflammatory molecules was significantly increased. At six months of age, we also observed an increase in gene expression of pro-inflammatory molecules, whereas L-arg supplementation prevented this increase at both ages. Our data suggest that activation of inflammatory pathways is present early in the kidney of DO rats, and that L-arg can attenuate the expression of these markers of tissue inflammation. Our results also reinforce the concept that intrauterine environmental factors are a fundamental determinant in the development of metabolic and vascular diseases later in life.

  5. A Multi-Time Scale Morphable Software Milieu for Polymorphous Computing Architectures (PCA) - Composable, Scalable Systems

    DTIC Science & Technology

    2004-10-01

    metadata specification, mapping metadata with components, user-driven selection of “best” alternatives for components given mission goals, and the ...approaches studied during the research could be applied into the real world problem for PCA applications. These concepts include componentization of ...No. 1, pp. 1-22, 2003. [17] E. A. Lee, "Overview of the Ptolemy Project," Technical Memorandum UCB/ERL M01/11, University of California, Berkeley

  6. The influence of the milieu on the rate of neutralisation of herpes simplex virus 1.

    PubMed

    Bolt, C E; Davies, J A; Randall, S; Skinner, G R

    1998-01-01

    The rate of neutralisation of herpes simplex virus 1 was increased by up to more than five hundred-fold when the virus suspension and antiserum were each diluted to one hundred-fold in water instead of phosphate buffered saline. This phenomenon, which was observed for two human positive sera and a rabbit purified polyclonal antibody, may represent an unrecognised homeostatic mechanism where neutralising antibody is 'dilution-fast' under physiological conditions of transudation or pathological conditions of inflammation.

  7. "Mesogeny" (Milieu-Mediated Maturation) Versus Endogeny: A Crucial Underemphasis in Piaget's "Internally-Caused" Phases.

    ERIC Educational Resources Information Center

    Burger, Henry G.

    The author credits Piaget for giving an operational definition of deduction and for his descriptions of child behavior. But he states that the latter apply only to white, middle-class urban youths in Switzerland in the first half of the 20th century and cannot support Piaget's claims about invariant stages of intellectual development for all…

  8. The dental school learning milieu: students' perceptions at five academic dental institutions in Pakistan.

    PubMed

    Ali, Kamran; Raja, Mahwish; Watson, Gordon; Coombes, Lee; Heffernan, Eithne

    2012-04-01

    The significance of the educational environment in health professions academic institutions, increasingly recognized on a global scale, is fundamental to effective student learning. This study was carried out to evaluate students' perceptions of the educational environment in five undergraduate dental institutions in Pakistan. This non-interventional study used a postal questionnaire based on the Dundee Ready Educational Environment Measure (DREEM). The subjects were dental students taking the final professional B.D.S. examination at five dental institutions affiliated with the University of Health Sciences, Lahore, Pakistan. A total of 197 students participated in the study (response rate of 83.82 percent). The overall DREEM score was 115.06 (Cronbach's alpha 0.87). Nine items recorded scores <2 and were flagged for remediation. Significant differences were observed between students' perceptions of learning and of teachers (p<0.05). Many issues challenge the quality and delivery of dental education in Pakistan, and dental institutions need to develop robust mechanisms to incorporate contemporary international trends in dental education in order to improve the educational environment.

  9. Transmembrane domains interactions within the membrane milieu: principles, advances and challenges.

    PubMed

    Fink, Avner; Sal-Man, Neta; Gerber, Doron; Shai, Yechiel

    2012-04-01

    Protein-protein interactions within the membrane are involved in many vital cellular processes. Consequently, deficient oligomerization is associated with known diseases. The interactions can be partially or fully mediated by transmembrane domains (TMD). However, in contrast to soluble regions, our knowledge of the factors that control oligomerization and recognition between the membrane-embedded domains is very limited. Due to the unique chemical and physical properties of the membrane environment, rules that apply to interactions between soluble segments are not necessarily valid within the membrane. This review summarizes our knowledge on the sequences mediating TMD-TMD interactions which include conserved motifs such as the GxxxG, QxxS, glycine and leucine zippers, and others. The review discusses the specific role of polar, charged and aromatic amino acids in the interface of the interacting TMD helices. Strategies to determine the strength, dynamics and specificities of these interactions by experimental (ToxR, TOXCAT, GALLEX and FRET) or various computational approaches (molecular dynamic simulation and bioinformatics) are summarized. Importantly, the contribution of the membrane environment to the TMD-TMD interaction is also presented. Studies utilizing exogenously added TMD peptides have been shown to influence in vivo the dimerization of intact membrane proteins involved in various diseases. The chirality independent TMD-TMD interactions allows for the design of novel short d- and l-amino acids containing TMD peptides with advanced properties. Overall these studies shed light on the role of specific amino acids in mediating the assembly of the TMDs within the membrane environment and their contribution to protein function. This article is part of a Special Issue entitled: Protein Folding in Membranes.

  10. Altered Intracellular Milieu of ADAR2-Deficient Motor Neurons in Amyotrophic Lateral Sclerosis

    PubMed Central

    Yamashita, Takenari; Akamatsu, Megumi; Kwak, Shin

    2017-01-01

    Transactive response DNA-binding protein (TDP-43) pathology, and failure of A-to-I conversion (RNA editing) at the glutamine/arginine (Q/R) site of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor subunit GluA2, are etiology-linked molecular abnormalities that concomitantly occur in the motor neurons of most patients with amyotrophic lateral sclerosis (ALS). Adenosine deaminase acting on RNA 2 (ADAR2) specifically catalyzes GluA2 Q/R site-RNA editing. Furthermore, conditional ADAR2 knockout mice (AR2) exhibit a progressive ALS phenotype with TDP-43 pathology in the motor neurons, which is the most reliable pathological marker of ALS. Therefore, the evidence indicates that ADAR2 downregulation is a causative factor in ALS, and AR2 mice exhibit causative molecular changes that occur in ALS. We discuss the contributors to ADAR2 downregulation and TDP-43 pathology in AR2 mouse motor neurons. We describe mechanisms of exaggerated Ca2+ influx amelioration via AMPA receptors, which is neuroprotective in ADAR2-deficient motor neurons with normalization of TDP-43 pathology in AR2 mice. Development of drugs to treat diseases requires appropriate animal models and a sensitive method of evaluating efficacy. Therefore, normalization of disrupted intracellular environments resulting from ADAR2 downregulation may be a therapeutic target for ALS. We discuss the development of targeted therapy for ALS using the AR2 mouse model. PMID:28208729

  11. Foregut exclusion disrupts intestinal glucose sensing and alters portal nutrient and hormonal milieu.

    PubMed

    Pal, Atanu; Rhoads, David B; Tavakkoli, Ali

    2015-06-01

    The antidiabetes effects of Roux-en-Y gastric bypass (RYGB) are well-known, but the underlying mechanisms remain unclear. Isolating the proximal small intestine, and in particular its luminal glucose sensors, from the nutrient stream has been proposed as a critical change, but the pathways involved are unclear. In a rodent model, we tested the effects of isolating and then stimulating a segment of proximal intestine using glucose analogs to examine their impact on glucose absorption (Gabsorp) and hormone secretion after a glucose bolus into the distal jejunum. Analogs selective for sodium-glucose cotransporter (SGLT) family members and the sweet taste receptor were tested, and measurements of the portosystemic gradient were used to determine Gabsorp and hormone secretion, including GLP-1. Proximal intestinal isolation reduced Gabsorp and GLP-1 secretion. Stimulation of the glucose-sensing protein SGLT3 increased Gabsorp and GLP-1 secretion. These effects were abolished by vagotomy. Sweet taste receptor stimulation only increased GLP-1 secretion. This study suggests a novel role for SGLT3 in coordinating intestinal function, as reflected by the concomitant modulation of Gabsorp and GLP-1 secretion, with these effects being mediated by the vagus nerve. Our findings provide potential mechanistic insights into foregut exclusion in RYGB and identify SGLT3 as a possible antidiabetes therapeutic target.

  12. Endochitinase Is Transported to the Extracellular Milieu by the eps-Encoded General Secretory Pathway of Vibrio cholerae

    PubMed Central

    Connell, Terry D.; Metzger, Daniel J.; Lynch, Jennifer; Folster, Jason P.

    1998-01-01

    The chiA gene of Vibrio cholerae encodes a polypeptide which degrades chitin, a homopolymer of N-acetylglucosamine (GlcNAc) found in cell walls of fungi and in the integuments of insects and crustaceans. chiA has a coding capacity corresponding to a polypeptide of 846 amino acids having a predicted molecular mass of 88.7 kDa. A 52-bp region with promoter activity was found immediately upstream of the chiA open reading frame. Insertional inactivation of the chromosomal copy of the gene confirmed that expression of chitinase activity by V. cholerae required chiA. Fluorescent analogues were used to demonstrate that the enzymatic activity of ChiA was specific for β,1-4 glycosidic bonds located between GlcNAc monomers in chitin. Antibodies against ChiA were obtained by immunization of a rabbit with a MalE-ChiA hybrid protein. Polypeptides with antigenic similarity to ChiA were expressed by classical and El Tor biotypes of V. cholerae and by the closely related bacterium Aeromonas hydrophila. Immunoblotting experiments using the wild-type strain 569B and the secretion mutant M14 confirmed that ChiA is an extracellular protein which is secreted by the eps system. The eps system is also responsible for secreting cholera toxin, an oligomeric protein with no amino acid homology to ChiA. These results indicate that ChiA and cholera toxin have functionally similar extracellular transport signals that are essential for eps-dependent secretion. PMID:9791107

  13. Disclosure of a structural milieu for the proximity ligation reveals the elusive nature of an active chromatin hub

    PubMed Central

    Gavrilov, Alexey A.; Gushchanskaya, Ekaterina S.; Strelkova, Olga; Zhironkina, Oksana; Kireev, Igor I.; Iarovaia, Olga V.; Razin, Sergey V.

    2013-01-01

    The current progress in the study of the spatial organization of interphase chromosomes became possible owing to the development of the chromosome conformation capture (3C) protocol. The crucial step of this protocol is the proximity ligation—preferential ligation of DNA fragments assumed to be joined within nuclei by protein bridges and solubilized as a common complex after formaldehyde cross-linking and DNA cleavage. Here, we show that a substantial, and in some cases the major, part of DNA is not solubilized from cross-linked nuclei treated with restriction endonuclease(s) and sodium dodecyl sulphate and that this treatment neither causes lysis of the nucleus nor drastically affects its internal organization. Analysis of the ligation frequencies of the mouse β-globin gene domain DNA fragments demonstrated that the previously reported 3C signals were generated predominantly, if not exclusively, in the insoluble portion of the 3C material. The proximity ligation thus occurs within the cross-linked chromatin cage in non-lysed nuclei. The finding does not compromise the 3C protocol but allows the consideration of an active chromatin hub as a folded chromatin domain or a nuclear compartment rather than a rigid complex of regulatory elements. PMID:23396278

  14. Disclosure of a structural milieu for the proximity ligation reveals the elusive nature of an active chromatin hub.

    PubMed

    Gavrilov, Alexey A; Gushchanskaya, Ekaterina S; Strelkova, Olga; Zhironkina, Oksana; Kireev, Igor I; Iarovaia, Olga V; Razin, Sergey V

    2013-04-01

    The current progress in the study of the spatial organization of interphase chromosomes became possible owing to the development of the chromosome conformation capture (3C) protocol. The crucial step of this protocol is the proximity ligation-preferential ligation of DNA fragments assumed to be joined within nuclei by protein bridges and solubilized as a common complex after formaldehyde cross-linking and DNA cleavage. Here, we show that a substantial, and in some cases the major, part of DNA is not solubilized from cross-linked nuclei treated with restriction endonuclease(s) and sodium dodecyl sulphate and that this treatment neither causes lysis of the nucleus nor drastically affects its internal organization. Analysis of the ligation frequencies of the mouse β-globin gene domain DNA fragments demonstrated that the previously reported 3C signals were generated predominantly, if not exclusively, in the insoluble portion of the 3C material. The proximity ligation thus occurs within the cross-linked chromatin cage in non-lysed nuclei. The finding does not compromise the 3C protocol but allows the consideration of an active chromatin hub as a folded chromatin domain or a nuclear compartment rather than a rigid complex of regulatory elements.

  15. Work-Related Child-Care Centres in Canada, 2001 = Les garderies en milieu de travail au Canada, 2001.

    ERIC Educational Resources Information Center

    Barbeau, Carole

    Noting that the number of work-related child care centers has nearly doubled in the past 10 years in Canada, this report, in both English and French, details a study examining the current practices pertaining to work-related child care in Canada. The report highlights the best examples in this area and discusses what has been learned from the…

  16. Substance Use and Dependency Disorders in Adolescent Girls in Group Living Programs: Prevalence and Associations with Milieu Factors

    ERIC Educational Resources Information Center

    Baker, Amy J. L.; Ashare, Caryn; Charvat, Benjamin J.

    2009-01-01

    Fifty-three adolescent girls residing in community-based group-living child welfare programs were administered a standardized measure (SASS-2) in order to assess probability of a substance use/dependency disorder in this highly vulnerable population. Findings revealed that one third of the sample, and one half of the nonpregnant/parenting girls,…

  17. Le Courrier Electronique: Un Outil d'Enseignement en Milieu de Travail (Electronic Mail: A Teaching Tool in the Workplace).

    ERIC Educational Resources Information Center

    Desmarais, Lise

    1999-01-01

    Describes a course that used e-mail to improve the German and Spanish written language skills of Canadian Foreign Service Officers. To lower attrition rates, the course required completion of authentic professional tasks, exposing participants to formal, technical, and informal language. Though initial interest was high, attrition was also high,…

  18. Solubilitéet croissance de la berlinite AlPO 4, en milieu phospho-sulfurique

    NASA Astrophysics Data System (ADS)

    Cambon, O.; Goiffon, A.; Philippot, E.

    1989-01-01

    La solubilitéde la berlinite, AlPO 4, aétémesurée dans des mélanges d'acide phosphorique et sulfurique en différentes proportions. Dans ces milieux, la solubilitéest toujours de type rétrograde et intermédiaire entre celle déterminée dans chacun des deux acides. La croissance cristalline réalisée dans ce solvant mixte conduita`des cristaux dont la morphologie est elle aussi intermédiairea`celles observées dans H 3PO 4 et H 2SO 4. Cette observation montre que l'utilisation de mélanges d'acide permet de moduler les vitesses de croissance et peuteˆtre un moyen de mieux maiˆtriser celles-ci.

  19. COX-2 FROM THE INJURY MILIEU IS CRITICAL FOR THE INITIATION OF PERIOSTEAL PROGENITOR CELL MEDIATED BONE HEALING

    PubMed Central

    Xie, Chao; Ming, Xue; Wang, Qun; Schwarz, Edward M.; Guldberg, Robert E.; O’Keefe, Regis J.; Zhang, Xinping

    2009-01-01

    Although a critical role of COX-2 in bone repair has been established, the mechanism involved remains unclear. During early inflammatory phase of bone healing, COX-2 is produced by the surrounding inflammatory cells as well as bone/cartilage progenitors. Based on the temporal and spatial expression of COX-2 during the early phase of fracture healing, we hypothesize that COX-2 from both sources is critical for progenitor cell activation, proliferation and differentiation. To directly test this we utilized a murine femoral grafting model, in which live segmental grafts from the same strains were transplanted and donor versus host cell involvement in healing was assessed. Specifically, fresh femur cortical bone grafts of 4-mm in length from COX-2-/- (KO) mice were transplanted into wild type (WT) mice with the same sized segmental defect in femurs. Similarly, grafts from WT were transplanted into the defects in KO mice. As controls, transplantations between wild types, and transplantations between KO were also performed. Histologic analyses showed that WT-to-WT transplantation resulted in normal endochondral bone healing as evidenced by markedly induction of neovascularization and periosteal bone formation on donor graft. In contrast, transplantation of KO graft into KO host led to 96 % reduction of bone formation and near elimination of donor cell-initiated periosteal bone formation. Similarly, transplantation of WT graft into a KO host resulted in 87% reduction of bone formation (n=8, p>0.05), indicating that KO host impaired WT donor progenitor cell expansion and differentiation. When a KO graft was transplanted into WT host, KO donor periosteal cell-initiated endochondral bone formation was restored. Histomorphometric analyses demonstrated 10-fold increase in bone formation and 3-fold increase in cartilage formation compared to KO-to-KO transplantation (n=8, p<0.05), suggesting that COX-2 deficient donor cells were capable to differentiate and form bone when placed in a WT host. Taken together, our data strongly suggest that COX-2 is critical for initiation of periosteal cortical bone healing. The early induction of COX-2 constitutes a crucial host-healing environment for activation and differentiation of donor periosteal progenitors. Elimination of COX-2 at the early stage of healing could lead to detrimental effects on periosteal progenitor cell-initiated cortical bone repair. PMID:18773980

  20. The Social Milieu of the Church and Religious Coping Responses: A Longitudinal Investigation of Older Whites and Older Blacks.

    PubMed

    Krause, Neal

    2010-04-01

    The purpose of this study is to see if the social environment of the church influences the use of religious coping responses over time. The following theoretical relationships were embedded in the conceptual model that was developed to evaluate this issue: (1) people who go to church more often are more likely to feel their congregation is highly cohesive (e.g., share the same values and beliefs); (2) individuals who worship in highly cohesive congregations are more likely to receive spiritual support (i.e., encouragement to adopt religious teachings and principles) from their fellow church members; (3) people who receive more spiritual support will be more likely to adopt religious coping responses. In the process of evaluating this model, tests were performed to examine the influence of racial culture. Data from a nationwide longitudinal survey of older adults provide support for each link in the conceptual model. Pervasive racial cultural differences were also found: Older blacks were more likely to be deeply involved in each facet of religion than older whites.

  1. Benefices environnementaux de la cogeneration d'energie en milieu hospitalier et cas de l'Hopital de Moncton

    NASA Astrophysics Data System (ADS)

    Kone, Diakalia

    The present study aimed at assessing the environmental benefits of power management practices based on cogeneration in the particular industrial sector of hospitals and healthcare. Cogeneration power systems, also known as "Combined Heat and Power" (CHP) or Cogen, supply on-site electricity and heat from a single fuel source (natural gas in general). While the efficiency of conventional plants to produce power and heat separately is limited to about 30%, the efficiency of a CHP plant is close to 80% and can reach up to 90% in some applications (Borbely et Kreider, 2001). One of the distinctive features of hospitals is their continuous demand for both type of energy (electricity and heat), which makes them good candidate for cogeneration. However, in North America at the present time, less than 5% of hospitals run on CHP. Most are being supplied with electricity by conventional power plants, run by specialized companies, and use on-site boiler(s) to generate heat. Energy spending can reach up to 3% of an hospital's annual operational budget. There are also environmental impacts related to current energy supply and use in hospitals. For instance, the burning of fossil fuels releases greenhouse gases (GHG), which contribute to human health problems and climate change. The first objective of the study was to outline the main benefits and challenges faced by hospitals that aim at becoming their own energy co-generator, in comparison to having power and heat produced separately. Our second objective was to assess prospectively (proactively) the environmental impacts of a cogeneration plant that is being planned, but not yet operated, in a Canadian hospital. The methodology was based on literature reviews and on a case study, namely that of The Moncton Hospital (TMH)/L'Hopital de Moncton, Moncton, New Brunswick, Canada. This hospital is considered a large hospital with 375 beds and a major and expanding ambulatory care service. It is also in the process of developing a 1.06 MW cogeneration plant, to be run on natural gas, to meet about 30% of the facility's current demand for electricity and heat. In order to anticipate the environmental consequences of this CHP project, an environmental impact assessment (EIA) was conducted, according to the principles that apply in New Brunswick (Regulation 87-83 on EIA). A literature review was conducted and a matrix approach (matrix of impacts) was used to identify and assess the anticipated environmental impacts. The study showed that multiple stakeholders in the healthcare sector can reap benefits of CHP deployment. Facility owners can reduce energy costs and increase power reliability to enhance operations' continuity, during normal and extraordinary times (e.g., natural disasters). For instance, when hurricanes Katrina and Rita struck the United States in 2005, hospitals running with CHP were able to provide secure electricity supplies for emergency facilities and shelters. CHP also has environmental benefits related to its distinctively high efficiency. But its deployment in the healthcare sector also provides challenges, mainly due to the fact that power production is not a core activity for an hospital. These challenges can be overcome, however, as shown by numerous success stories in hospitals worldwide; specialised resources are available to help hospitals switch to CHP. This study underlines some of the steps a hospital can take toward this aim. EIA of The Moncton Hospital CHP project suggests that, globally, the environmental impacts of CHP are reduced compared to the traditional production of electricity and heat separately. Cogeneration utilizes fewer resources (fuel) and therefore releases fewer GHG and other pollutants. However, quantifying the emissions avoided is challenging. Also, the environmental benefits of CHP may be less obvious when compared to a centralised nuclear or hydraulic power production, which emits less GHG than power plants operating on coal or fuel oil. The study also indicates that other conditions are required to increase the environmental gains that can be expected from CHP deployment in the hospital sector. These conditions include the use of renewable fuel sources (biomass), the development of well-structured frameworks (e.g., efficient environmental management systems) to coordinate and leverage environmental stewardship initiatives within hospitals, and the development of energy partnerships (e.g., municipal heat networks). A broad, eco-systemic vision, like the one of industrial ecology, would help strengthen the ecological benefits of cogeneration in the hospital and health care sector. Key Words Heat and power cogeneration, hospitals, benefits/challenges, environment, society, environmental impact assessment, Canada, sustainable development, industrial ecology.

  2. Mental Health and Well-Being across the Military Spectrum (Bien-etre et sante mentale dans le milieu militaire)

    DTIC Science & Technology

    2011-04-01

    seek help. Implementing the desirable attitude change within a traditionally tough ( macho ) military culture is a real challenge and specific...changement souhaitable de comportement dans un environnement militaire de culture traditionnellement rude ( macho ) est un vrai défi, et il est recommandé

  3. Influence de la microporosité sur le piégeage du gaz dans un milieu poreux naturel

    NASA Astrophysics Data System (ADS)

    Suzanne, Karine; Billiotte, Joël

    2004-09-01

    Trapped-gas content in natural porous media, also called residual gas saturation ( Sgr), corresponds to the imbibition end-point. To define the parameters controlling Sgr, two parameters were studied: the influence of rock characteristics (on 400 sandstone samples) and initial gas saturation ( Sgi), on the basis of 60 experimental curves between Sgr and Sgi. Based on an extensive experimental database, this study establishes the dominant influence of microporosity on trapped gas saturation, and indirectly that of the contained clays. To cite this article: K. Suzanne, J. Billiotte, C. R. Geoscience 336 (2004).

  4. CD40 Gene Silencing Reduces the Progression of Experimental Lupus Nephritis Modulating Local Milieu and Systemic Mechanisms

    PubMed Central

    Ripoll, Èlia; Merino, Ana; Goma, Montse; Aran, Josep M.; Bolaños, Nuria; de Ramon, Laura; Herrero-Fresneda, Immaculada; Bestard, Oriol; Cruzado, Josep M.; Grinyó, Josep M.; Torras, Juan

    2013-01-01

    Lupus nephritis (LN) is an autoimmune disorder in which co-stimulatory signals have been involved. Here we tested a cholesterol-conjugated-anti-CD40-siRNA in dendritic cells (DC) in vitro and in a model of LPS to check its potency and tissue distribution. Then, we report the effects of Chol-siRNA in an experimental model of mice with established lupus nephritis. Our in vitro studies in DC show a 100%intracellular delivery of Chol-siRNA, with a significant reduction in CD40 after LPS stimuli. In vivo in ICR mice, the CD40-mRNA suppressive effects of our Chol-siRNA on renal tissue were remarkably sustained over a 5 days after a single preliminary dose of Chol-siRNA. The intra-peritoneal administration of Chol-siRNA to NZB/WF1 mice resulted in a reduction of anti-DNA antibody titers, and histopathological renal scores as compared to untreated animals. The higher dose of Chol-siRNA prevented the progression of proteinuria as effectively as cyclophosphamide, whereas the lower dose was as effective as CTLA4. Chol-siRNA markedly reduced insterstitialCD3+ and plasma cell infiltrates as well as glomerular deposits of IgG and C3. Circulating soluble CD40 and activated splenic lymphocyte subsets were also strikingly reduced by Chol-siRNA. Our data show the potency of our compound for the therapeutic use of anti-CD40-siRNA in human LN and other autoimmune disorders. PMID:23799000

  5. Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients.

    PubMed

    Rosenzwajg, Michelle; Churlaud, Guillaume; Mallone, Roberto; Six, Adrien; Dérian, Nicolas; Chaara, Wahiba; Lorenzon, Roberta; Long, S Alice; Buckner, Jane H; Afonso, Georgia; Pham, Hang-Phuong; Hartemann, Agnès; Yu, Aixin; Pugliese, Alberto; Malek, Thomas R; Klatzmann, David

    2015-04-01

    Most autoimmune diseases (AID) are linked to an imbalance between autoreactive effector T cells (Teffs) and regulatory T cells (Tregs). While blocking Teffs with immunosuppression has long been the only therapeutic option, activating/expanding Tregs may achieve the same objective without the toxicity of immunosuppression. We showed that low-dose interleukin-2 (ld-IL-2) safely expands/activates Tregs in patients with AID, such HCV-induced vasculitis and Type 1 Diabetes (T1D). Here we analyzed the kinetics and dose-relationship of IL-2 effects on immune responses in T1D patients. Ld-IL-2 therapy induced a dose-dependent increase in CD4(+)Foxp3(+) and CD8(+)Foxp3(+) Treg numbers and proportions, the duration of which was markedly dose-dependent. Tregs expressed enhanced levels of activation markers, including CD25, GITR, CTLA-4 and basal pSTAT5, and retained a 20-fold higher sensitivity to IL-2 than Teff and NK cells. Plasma levels of regulatory cytokines were increased in a dose-dependent manner, while cytokines linked to Teff and Th17 inflammatory cells were mostly unchanged. Global transcriptome analyses showed a dose-dependent decrease in immune response signatures. At the highest dose, Teff responses against beta-cell antigens were suppressed in all 4 patients tested. These results inform of broader changes induced by ld-IL-2 beyond direct effects on Tregs, and relevant for further development of ld-IL-2 for therapy and prevention of T1D, and other autoimmune and inflammatory diseases.

  6. Phenotypic effects of maternal immune activation and early postnatal milieu in mice mutant for the schizophrenia risk gene neuregulin-1.

    PubMed

    O'Leary, C; Desbonnet, L; Clarke, N; Petit, E; Tighe, O; Lai, D; Harvey, R; Waddington, J L; O'Tuathaigh, C

    2014-09-26

    Risk of schizophrenia is likely to involve gene × environment (G × E) interactions. Neuregulin 1 (NRG1) is a schizophrenia risk gene, hence any interaction with environmental adversity, such as maternal infection, may provide further insights into the basis of the disease. This study examined the individual and combined effects of prenatal immune activation with polyriboinosinic-polyribocytidilic acid (Poly I:C) and disruption of the schizophrenia risk gene NRG1 on the expression of behavioral phenotypes related to schizophrenia. NRG1 heterozygous (NRG1 HET) mutant breeding pairs were time-mated. Pregnant dams received a single injection (5mg/kg i.p.) of Poly I:C or vehicle on gestation day 9 (GD9). Offspring were then cross-fostered to vehicle-treated or Poly I:C-treated dams. Expression of schizophrenia-related behavioral endophenotypes was assessed at adolescence and in adulthood. Combining NRG1 disruption and prenatal environmental insult (Poly I:C) caused developmental stage-specific deficits in social behavior, spatial working memory and prepulse inhibition (PPI). However, combining Poly I:C and cross-fostering produced a number of behavioral deficits in the open field, social behavior and PPI. This became more complex by combining NRG1 deletion with both Poly I:C exposure and cross-fostering, which had a robust effect on PPI. These findings suggest that concepts of G × E interaction in risk of schizophrenia should be elaborated to multiple interactions that involve individual genes interacting with diverse biological and psychosocial environmental factors over early life, to differentially influence particular domains of psychopathology, sometimes over specific stages of development.

  7. Body size of terrestrial arthropods and biomass of their populations in relation to the abiotic parameters of their milieu.

    PubMed

    Remmert, Hermann

    1981-08-01

    From collections made in very different biotopes of very different zoogeographical regions it is concluded that the biomass per area, the average body size, and the number of winged insects and spiders are primarily governed by the relative humidity of the biotope. From this finding several predictions are put forward on parental care, social systems, activity time and predators in different biotopes all of which seem to support the hypothesis.

  8. Endocrine milieu of perioestrus in the giant panda (Ailuropoda melanoleuca), as determined by non-invasive hormone measures.

    PubMed

    Kersey, David C; Wildt, David E; Brown, Janine L; Snyder, Rebecca J; Huang, Yan; Monfort, Steven L

    2010-01-01

    The aim of the present study was to determine the efficacy of faecal hormonal measures for evaluating ovarian activity in a significant sized cohort of giant pandas during the perioestrual period. Faecal excretion of oestrogen and progestagen metabolites corresponded with urinary patterns and receptive behaviours. Longitudinal assessment of 10 females revealed that, on average, faecal oestrogen concentrations started to rise (P < 0.05) above baseline (baseline mean +/- s.e.m.; 64.7 +/- 6.6 ng g(-1)) 5 days before the preovulatory oestrogen peak (484.6 +/- 126.8 ng g(-1)), which was followed by a gradual descent over 4 days to nadir. Mean faecal progestagen metabolite concentrations increased approximately twofold above baseline (from 186.2 +/- 37.7 to 347.2 +/- 75.7 ng g(-1); P < 0.05) during the 20-day interval after the preovulatory oestrogen surge. Variability within and among females precluded the use of a threshold of oestrogen or progestagen metabolites to predict reproductive status, yet faeces collected 2-3 days per week provided sufficient data to recognise that an individual was in the perioestrual period. Finally, in females that were examined for at least 3 consecutive years, there was an 18-53 day variation in the onset and an 8-13 day variation in the duration of perioestrual behaviour from year to year. In summary, these findings indicate that gonadal hormone profiles associated with the period immediately before, during and after oestrus are accurately revealed by analysis of the fibrous faeces of the giant panda. This approach has potential value for providing point-in-time information on the reproductive status of free-living individuals.

  9. New Ecological Paradigm and Sustainability Attitudes with Respect to a Multi-Cultural Educational Milieu in China

    ERIC Educational Resources Information Center

    Wells, Mona; Petherick, Lynda

    2016-01-01

    Institutions of higher education are increasingly interested in how the student experience may or may not influence world views and particularly with respect to sustainability. Here we report preliminary results from a New Ecological Paradigm (NEP) study in China to benchmark student responses, and we relate these results to findings from other…

  10. The effect of 17 beta-estradiol on cholesterol in human macrophages is influenced by the lipoprotein milieu

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Estrogen and testosterone are thought to modulate coronary heart disease (CHD) risk. To examine how these hormones affect human macrophage cholesterol transport, a key factor in atherogenesis, we obtained monocytes from healthy male and postmenopausal female donors (age 50-70 y). Cells were allowe...

  11. Metabolic surgery: action via hormonal milieu changes, changes in bile acids or gut microbiota? A summary of the literature

    PubMed Central

    Sweeney, Timothy E.; Morton, John M.

    2015-01-01

    Obesity and type 2 diabetes remain epidemic problems. Different bariatric surgical techniques causes weight loss and diabetes remission to varying degrees. The underlying mechanisms of the beneficial effects of bariatric surgery are complex, and include changes in diet and behavior, as well as changes in hormones, bile acid flow, and gut bacteria. We summarized the effects of multiple different bariatric procedures, and their resulting effects on several hormones (leptin, ghrelin, adiponectin, glucagon-like peptide 1 (GLP-1), peptide YY, and glucagon), bile acid changes in the gut and the serum, and resulting changes to the gut microbiome. As much as possible, we have tried to incorporate multiple studies to try to explain underlying mechanistic changes. What emerges from the data is a picture of clear differences between restrictive and metabolic procedures. The latter, in particular the roux-en-Y gastric bypass, induces large and distinctive changes in most measured fat and gut hormones, including early and sustained increase in GLP-1, possible through intestinal bile acid signaling. The changes in bile flow and the gut microbiome are causally inseparable so far, but new studies show that each contributes to the effects of weight loss and diabetes resolution. PMID:25194186

  12. Teaching Parents Enhanced Milieu Teaching with Words and Signs Using the Teach-Model-Coach-Review Model

    ERIC Educational Resources Information Center

    Wright, Courtney A.; Kaiser, Ann P.

    2017-01-01

    Measuring treatment fidelity is an essential step in research designed to increase the use of evidence-based practices. For parent-implemented communication interventions, measuring the implementation of the teaching and coaching provided to the parents is as critical as measuring the parents' delivery of the intervention to the child. Both levels…

  13. Immigrants living in an urban milieu with sanitation in Southern Italy: persistence and transmission of intestinal parasites.

    PubMed

    Gualdieri, Luciano; Piemonte, Monica; Alfano, Settimia; Maffei, Rita; Della Pepa, Maria Elena; Rinaldi, Laura; Galdiero, Marilena; Galdiero, Massimiliano; Cringoli, Giuseppe

    2016-03-01

    In the current era of globalization, the massive movement of populations to developed countries causes a greater attention to neglected tropical diseases in places where such diseases are considered unusual. The present study was planned to assess the persistence of intestinal parasitosis in immigrants stably living in the urban central area of Naples (Southern Italy) and the spread of infection within households with a lifestyle similar to that of the country of origin. A total of 2150 stool samples were analysed with the FLOTAC dual technique, and 415 subjects (19.3 %) tested positive for pathogenic intestinal parasites. One hundred ninety-six subjects were randomly selected and monitored again after 1 year in order to evaluate the persistence of intestinal parasites in immigrants having access to proper sanitation. No pathogenic parasites were found in these 196 samples. A total of 482 cohabitants of 151 positive subjects were recruited to evaluate the interfamilial spread of the identified parasites. Only in 18 households were there subjects infected with the same parasite. Monitoring of parasites in stool samples of immigrants showed a decrease of almost all pathogenic species over the years. From the analysis of households, it is not possible to assert that there is a familial transmission. Our study provides evidence that the prevalence of parasitic infections in immigrants is likely related to the poor sanitary habits of the country of origin and that acquisition of new sanitary regulations, together with the administration of pharmacological treatment, limits the transmission in the households and in the local population of their destination.

  14. The importance of selecting a proper biological milieu for protein corona analysis in vitro: Human plasma versus human serum.

    PubMed

    Mirshafiee, Vahid; Kim, Raehyun; Mahmoudi, Morteza; Kraft, Mary L

    2016-06-01

    Nanoparticle (NP) exposure to biological fluids in the body results in protein binding to the NP surface, which forms a protein coating that is called the "protein corona". To simplify studies of protein-NP interactions and protein corona formation, NPs are incubated with biological solutions, such as human serum or human plasma, and the effects of this exposure are characterized in vitro. Yet, how NP exposure to these two different biological milieus affects protein corona composition and cell response has not been investigated. Here, we explore the differences between the protein coronas that form when NPs are incubated in human serum versus human plasma. NP characterization indicated that NPs that were exposed to human plasma had higher amounts of proteins bound to their surfaces, and were slightly larger in size than those exposed to human serum. In addition, significant differences in corona composition were also detected with gel electrophoresis and liquid chromatography-mass spectrometry/mass spectrometry, where a higher fraction of coagulation proteins and complement factors were found on the plasma-exposed NPs. Flow cytometry and confocal microscopy showed that the uptake of plasma-exposed NPs was higher than that of serum-exposed NPs by RAW 264.7 macrophage immune cells, but not by NIH 3T3 fibroblast cells. This difference is likely due to the elevated amounts of opsonins, such as fibrinogen, on the surfaces of the NPs exposed to plasma, but not serum, because these components trigger NP internalization by immune cells. As the human plasma better mimics the composition of the in vivo environment, namely blood, in vitro protein corona studies should employ human plasma, and not human serum, so the biological phenomena that is observed is more similar to that occurring in vivo.

  15. Caracterisation de l'effet du vieillissement en milieu aqueux sur les proprietes mecaniques de composites a matrice elastomere

    NASA Astrophysics Data System (ADS)

    Favre, Audrey

    Rubber composites are widely used in several engineering fields, such as automotive, and more recently for inflatable dams and other innovative underwater applications. These rubber materials are composed by an elastomeric matrix while the reinforcing phase is a synthetic fabric. Since these components are expected to operate several years in water environment, their durability must be guaranteed. The use of rubber materials immersed in water is not new, in fact, these materials have been studied for almost one century. However, the knowledge on reinforced rubber composites immersed several years in water is still limited. In this work, investigations on reinforced rubbers were carried out in the framework of a research project in partnership with Alstom and Hydro-Quebec. The objective of this study was to identify rubber composites that could be used under water for long periods. Various rubber composites with ethylene-propylene-diene monomer (EPDM), silicone, EPDM/silicone and polychloroprene (Neoprene) matrices reinforced with E-glass fabric were studied. Thus, these materials were exposed to an accelerated ageing at 85 °C underwater for periods varying from 14 to 365 days. For comparison purposes, they were also immersed and aged one year at room temperature (21 °C). The impact of accelerated aging was estimated through three different characterization methods. Scanning electron microscopy (SEM) was first used to assess the quality of fiber-matrix interface. Then, water absorption tests were performed to quantify the rate of water absorption during immersion. Finally the evolution of the mechanical properties was followed by the determination of Young's modulus (E) and ultimate stress (sigmau) using a dedicated traction test. This analysis allowed to point out that the quality of the fiber-matrix interface was the main factor influencing the drop of the mechanical properties and their durability. Moreover, it was noticed that this interface could be improved by using appropriate coupling agent as confirmed by the silicone composite with treated fabric. It was also observed that fiber-matrix interface could be a place where high stresses were localized because of differential swelling leading to an important loss of mechanical properties. The results revealed very different behaviors from one composite to another. The accelerated aging of EPDM/silicone and Neoprene composites led to a rapid diminution of mechanical properties in only 14 days. Conversely, silicone composites showed a 20 % increase of mechanical properties after 75 days of immersion. EPDM composites exhibited an important variability from one sample to another. It can be concluded from this study that composites made from silicone matrix with treated E-glass result in a better durability underwater. Keywords: composite elastomer, accelerated ageing, immersion in the water

  16. Age-related switch of bone mass in p47phox deficient mice through increased inflammatory milieu in bone

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Bone remodeling is age-dependently regulated and changes dramatically during the course of development. Excessive accumulation of reactive oxygen species (ROS), including superoxide, hydrogen peroxide, and hydroxyl radicals, has been suggested to be the leading cause of many inflammatory and degener...

  17. Modelisation, conception et simulation des performances d'un collecteur solaire aeraulique a tubes sous vide en milieu nordique

    NASA Astrophysics Data System (ADS)

    Paradis, Pierre-Luc

    The global energy consumption is still increasing year after year even if different initiatives are set up to decrease fossil fuel dependency. In Canada 80% of the energy is used for space heating and domestic hot water heating in residential sector. This heat could be provided by solar thermal technologies despite few difficulties originating from the cold climate. The aim of this project is to design a solar evacuated tube thermal collector using air as the working fluid. Firstly, needs and specifications of the product are established in a clear way. Then, three concepts of collector are presented. The first one relies on the standard evacuated tube. The second one uses a new technology of tubes; both sides are open. The third one uses heat pipe to extract the heat from the tubes. Based on the needs and specification as criteria, the concept involving tubes with both sides open has been selected as the best idea. In order to simulate the performances of the collector, a model of the heat exchanges in an evacuated tube was developed in 4 steps. The first step is a model in steady state intended to calculate the stagnation temperature of the tube for a fixed solar radiation, outside temperature and wind speed. As a second step, the model is generalised to transient condition in order to validate it with an experimental setup. A root mean square error of 2% is then calculated. The two remainder steps are intended to calculate the temperature of airflow leaving the tube. In the same way, a first model in steady state is developed and then generalised to the transient mode. Then, the validation with an experimental setup gave a difference of 0.2% for the root mean square error. Finally, a preindustrial prototype intended to work in open loop for preheating of fresh air is presented. During the project, explosion of the both sides open evacuated tube in overheating condition blocked the construction of a real prototype for the test. Different path for further work are also identified. One of these is in relation with CFD simulation of the uniformity of the airflow inside of the collector. Another one is the analysis of the design with a design of experiment plan.

  18. Morbidité et mortalité hospitalière des maladies cardiovasculaires en milieu tropical: exemple d'un centre hospitalier à Lomé (Togo)

    PubMed Central

    Damorou, Findibe; Baragou, Soodougoua; Pio, Machihuede; Afassinou, Yaovi M; N'da, N'kenon W; Pessinaba, Soulemane; Tchérou, Tchaa; Attiogbé, Halé; Ehlan, Koffi; Goeh-Akue, Edem; Yayehd, Komlavi

    2014-01-01

    Introduction Les maladies cardiovasculaires (MCV) occupent une place importante dans la mortalité en Afrique, situation inquiétante traduisant une transition épidémiologique rapide. La connaissance des groupes nosologiques les plus mortelles devrait aider à l’élaboration de politiques en matière de traitement et de prévention. Méthodes Il's agit d une étude rétrospective du 1er janvier 2006 au 31 décembre 2010, ayant inclus les patients hospitalisés pour une MCV selon la classification Internationale des maladies (CIM-10). Résultats La fréquentation hospitalière pour maladie MCV a augmenté au fil du temps; les maladies hypertensives étaient le premier motif d hospitalisation (66.8%). Les autres pathologies fréquentes étaient la maladie thromboembolique (9.1%), les syndromes coronaires aigus (SCA) (7.3%), l'insuffisance cardiaque (5.5%), les cardiomyopathies (5.3%). La majorité des sujets étaient jeunes (âge moyen: 55.1 ans) et il n'y avait pas de corrélation entre la durée d'hospitalisation et l’âge: r = + 0.024, p = 0.09. La mortalité globale était élevée (11%) et les taux de létalité élevés dans le SCA (27.9%), l'embolie pulmonaire (25%) et la péricardite (25%). Conclusion Les MCV sont responsables d'une hospitalisation croissante dans nos hôpitaux. L'absence d unité de soins intensifs cardiologiques et des méthodes de revascularisation coronaire, le manque de personnels qualifiés associés l'inexistence de sécurité sociale expliquent une mortalité élevée dans nos pays en voie de développement qui sans avoir achevé leur transition démographique entre en pleine transition épidémiologique. PMID:25018812

  19. Thumbs Down. A Classroom Response to Violence towards Women = Pouce. La prevention en milieu scolaire de la violence faite aux femmes.

    ERIC Educational Resources Information Center

    Canadian Teachers' Federation, Ottawa (Ontario).

    This booklet is designed to encourage age-appropriate classroom discussion and activities aimed at deterring violence against women. Teachers can address violence as an issue that touches the lives of teachers and students. Domestic violence against women cuts across socioeconomic, ethnic and cultural groups. Topics addressed by grade level…

  20. Eindrapportage doelfinancieringsgrogramma V910 Munitie: functionering, veiligheid en milieu (Final Report of Program V910 Munition: Functioning, Safety and Environmental Aspects)

    DTIC Science & Technology

    2005-09-01

    ondortokening, van eon niouw Data Exchange Agreement met do USA (MWDDEA-N-02-NE-4822) ’Combustion and Detonation Phenomena in Rocket Motors and Warheads...en XDT (vertraagdlonbekend naar detonatie overgang), van onbeschadigd en beschadigd materiaal. Het onderzoek is en zal (tot 2007 in V405) in het kader...Data Exchange Agreement (DEA) N-02-NE-4822 Onder de (oude en) vernieuwde DATA Exchange Agreement MWDDEA-N-(96)02- NE-4822 Combustion and detonation

  1. Sex Role and Attitudes Toward Institutional Violence Among College Youth: The Impact of Sex-Role Identification, Parental Socialization, and Socio-Cultural Milieu.

    ERIC Educational Resources Information Center

    Starr, Jerold M.; Cutler, Neal E.

    Attitudinal differences between males and females on certain issues have been repeatedly documented through commercial public polls and academic studies. One of these differences is the greater reluctance on the part of females to support the use of institutional violence as an instrument of public policy. This paper empirically explores the…

  2. PolyICLC Exerts Pro- and Anti-HIV Effects on the DC-T Cell Milieu In Vitro and In Vivo.

    PubMed

    Aravantinou, Meropi; Frank, Ines; Hallor, Magnus; Singer, Rachel; Tharinger, Hugo; Kenney, Jessica; Gettie, Agegnehu; Grasperge, Brooke; Blanchard, James; Salazar, Andres; Piatak, Michael; Lifson, Jeffrey D; Robbiani, Melissa; Derby, Nina

    2016-01-01

    Myeloid dendritic cells (mDCs) contribute to both HIV pathogenesis and elicitation of antiviral immunity. Understanding how mDC responses to stimuli shape HIV infection outcomes will inform HIV prevention and treatment strategies. The long double-stranded RNA (dsRNA) viral mimic, polyinosinic polycytidylic acid (polyIC, PIC) potently stimulates DCs to focus Th1 responses, triggers direct antiviral activity in vitro, and boosts anti-HIV responses in vivo. Stabilized polyICLC (PICLC) is being developed for vaccine adjuvant applications in humans, making it critical to understand how mDC sensing of PICLC influences HIV infection. Using the monocyte-derived DC (moDC) model, we sought to describe how PICLC (vs. other dsRNAs) impacts HIV infection within DCs and DC-T cell mixtures. We extended this work to in vivo macaque rectal transmission studies by administering PICLC with or before rectal SIVmac239 (SIVwt) or SIVmac239ΔNef (SIVΔNef) challenge. Like PIC, PICLC activated DCs and T cells, increased expression of α4β7 and CD169, and induced type I IFN responses in vitro. The type of dsRNA and timing of dsRNA exposure differentially impacted in vitro DC-driven HIV infection. Rectal PICLC treatment similarly induced DC and T cell activation and pro- and anti-HIV factors locally and systemically. Importantly, this did not enhance SIV transmission in vivo. Instead, SIV acquisition was marginally reduced after a single high dose challenge. Interestingly, in the PICLC-treated, SIVΔNef-infected animals, SIVΔNef viremia was higher, in line with the importance of DC and T cell activation in SIVΔNef replication. In the right combination anti-HIV strategy, PICLC has the potential to limit HIV infection and boost HIV immunity.

  3. Corrosion Fatigue and Environmentally Assisted Cracking in Aging Military Vehicles (le fatigue-corrosion et la fissuration en milieu ambiant des vehicules militaires vieillissants)

    DTIC Science & Technology

    2011-03-01

    health and environmental hazards. Cadmium, for example, is highly toxic in its metallic form and the plating bath contains cyanides. Thus, both the...the case of cadmium the problem is even more serious and widespread since the toxic metal is carried with the plated part throughout its entire life...Steels, Metals Park, OH, USA, American Society for Metals , p. 720, 1978. [7] “Standard Practice for Preparing, Cleaning, and Evaluating Corrosion Test

  4. Corrosion Fatigue and Environmentally Assisted Cracking in Aging Military Vehicles (La fatigue-corrosion et la fissuration en milieu ambiant des vehicules militaires vieillissants)

    DTIC Science & Technology

    2011-03-01

    health and environmental hazards. Cadmium, for example, is highly toxic in its metallic form and the plating bath contains cyanides. Thus, both the...the case of cadmium the problem is even more serious and widespread since the toxic metal is carried with the plated part throughout its entire life...Steels, Metals Park, OH, USA, American Society for Metals , p. 720, 1978. [7] “Standard Practice for Preparing, Cleaning, and Evaluating Corrosion Test

  5. Experiencias Educativas en el Medio Rural Colombiano. Serie Divulgacion No. 2. [Educational Experiences in the Rural Colombian Milieu. Circulation Series No. 2].

    ERIC Educational Resources Information Center

    Ministerio de Educacion Nacional, Bogota (Colombia). Centro Nacional de Documentacion e Informacion Pedagogica.

    In fulfillment of the Colombian National Government's educational policy aimed toward improving the rural population's level of living, two fundamental projects have been implemented. These projects have led to the creation of schools, the continuous extension of grades, and the creation of "Concentraciones de Desarrollo Rural." They…

  6. Modelisation par une approche milieu poreux de l'instabilite fluidelastique dans un faisceau de tubes soumis a un ecoulement diphasique transverse

    NASA Astrophysics Data System (ADS)

    Tixier, Eliott

    This work deals with the prediction the fluidelastic instability onset in a tube bundle subject to a two-phase cross-flow. The study of two-phase flows leads to numerous industrial applications, in particular in the nuclear energy field. Indeed, nuclear plants steam generators are subject to two-phase cross-flows that cause damaging vibrations. Repetitive stresses in the structure lead to mechanical fatigue that have many important consequences ranging from regular maintenance partial shutdowns of the plant to a nuclear incident. Steam generators are immense tube arrays counting up to hundreds of thousands of tubes, which makes their study a difficult task. Among the cause of these vibrations, the fluidelastic mechanism is certainly the most destructive one. Therefore, a lot of effort is being put within the research community into understanding this phenomenon and developing tools to predict its triggering. The present study aims at modeling and numerically simulating this instability in a tube bundle subject to a two-phase cross-flow. The main challenge is to develop a model able to simulate a bundle counting numerous tubes with a low computational cost, which is not possible with a direct approach (Direct Numerical Simulations, DNS). First, the averaging technique is presented and then applied to continuity and momentum conservation equations for both the flow and the structure. As the consequence, the model of the porous medium is obtained, in which the fluide-structure interactions are modeled and lumped into the equations. The modified form of the Navier--Stokes equations obtained is significantly cheaper in terms of computational cost. First, the volume averaging process filters many details of the flow such as the geometry of the tubes and small-scale vortices. The resulting macroscopic model presents smoother variations so that coarser meshes may be used. Second, the fluid mesh and the tubes are independent. Therefore, fixed meshes may be used to simulate unsteady problems. The averaged equations are solved by a finite element method and the code is verified using the method of manufactured solutions. Calibration and validation are conducted by comparing the results of simple test cases simulations to the results obtained by DNS simulations. The latter corresponds to the full-order model and results of fluid-structure simulations were presented in recent publications. Simulations were run for a tube bundle subject to a single-phase cross-flow using the porous medium model. The values of the fluidelastic onset critical velocity were compared to those obtained using DNS and to experimental data found in the literature. The predictions obtained tend to be overestimated with respect to reference data. The reason may be that the model itself fails to accurately represent the coupling of neighboring tubes. However, the porous medium approach is significantly less costly than DNS. The porous medium model is then extended to two-phase flows and more precisely to gas-liquid mixtures. The investigation is restricted to bubbly flows and low void fraction in order to stay within the physical boundaries of the model. The two-phase mixture is modeled by an Euler-Euler approach and gas-liquid interactions are modeled. The resulting code is again verified and validated and the results of the numerical simulations are compared to experimental data from the literature and local technical reports. The results obtained overestimate the values of the fluidelastic instability onset critical velocity. Nevertheless, the gap observed seems to be due to the single-phase fluid-structure coupling model. The reasons of scatter between the numerical results and experimental data are investigated and suggestions are made in order to improve the porous medium model.

  7. Detection automatique des changements du bati en milieu urbain sur des images a tres haute resolution spatiale (Ikonos et QuickBird) en utilisant des donnees cartographiques numeriques

    NASA Astrophysics Data System (ADS)

    Bouziani, Mourad

    The updating of cartographic databases in urban environments is a difficult and expensive task. It can be facilitated by an automatic change detection method. Several methods have been developed for medium and low spatial resolution images. These methods are not adapted for the very high spatial resolution images (VHSR) and are not applicable in urban environment. This study proposes a new method for change detection of buildings in urban environments from VHSR images and using existing digital cartographic data. The proposed methodology is composed of several stages. The existing knowledge on the buildings and the other urban objects are first modelled and saved in a knowledge base. All change detection rules are defined at this stage. Then, the image is segmented. The parameters of segmentation are computed thanks to the integration between the image and the geographical database (GDB). Thereafter, the segmented image is analyzed using the knowledge base to localize the segments where the change of building is likely to occur. The change detection rules are then applied on these segments to identify the segments that represent the changes of buildings. These changes represent the updates of buildings to add to the geographical database. Finally, the map representing changes is assessed before being integrated in the geographical database. The data used in this research concern the city of Sherbrooke (Quebec, Canada) and the city of Rabat (Morocco). For Sherbrooke, we used an Ikonos image acquired in October 2004, an Ikonos image acquired in July 2006 and a GDB at the scale of 1:20,000. For Rabat, a QuickBird image acquired in August 2004 has been used with a GDB at the scale of 1:10,000. The results of tests on several zones are encouraging. Indeed, the rate of good detection is of 90%. Concerning the geometric precision of detection, the mean error is 3 m for Ikonos and 2 m for QuickBird. The proposed method presents some limitations on the detection of the exact contours of the buildings. It could be improved by including a shape post-analysis of detected buildings. The proposed method can be integrated in a cartographic update process or as a method for the quality assessment of a topographic database.

  8. Bovine colostrum increases pore-forming claudin-2 protein expression but paradoxically not ion permeability possibly by a change of the intestinal cytokine milieu.

    PubMed

    Bodammer, Peggy; Kerkhoff, Claus; Maletzki, Claudia; Lamprecht, Georg

    2013-01-01

    An impaired intestinal barrier function is involved in the pathogenesis of inflammatory bowel disease (IBD). Several nutritional factors are supposed to be effective in IBD treatment but scientific data about the effects on the intestinal integrity remain scarce. Bovine colostrum was shown to exert beneficial effects in DSS-induced murine colitis, and the present study was undertaken to explore the underlying molecular mechanisms. Western blot revealed increased claudin-2 expression in the distal ileum of healthy mice after feeding with colostrum for 14 days, whereas other tight junction proteins (claudin-3, 4, 10, 15) remained unchanged. The colostrum-induced claudin-2 induction was confirmed in differentiated Caco-2 cells after culture with colostrum for 48 h. Paradoxically, the elevation of claudin-2, which forms a cation-selective pore, was neither accompanied by increased ion permeability nor impaired barrier function. In an in situ perfusion model, 1 h exposure of the colonic mucosa to colostrum induced significantly increased mRNA levels of barrier-strengthening cytokine transforming growth factor-β, while interleukine-2, interleukine-6, interleukine-10, interleukine-13, and tumor-necrosis factor-α remained unchanged. Thus, modulation of the intestinal transforming growth factor-β expression might have compensated the claudin-2 increase and contributed to the observed barrier strengthening effects of colostrum in vivo and in vitro.

  9. Influence d'une substitution partielle du ciment par du laitier de hauts fourneaux sur la résistance des mortiers en milieu acide

    NASA Astrophysics Data System (ADS)

    Achoura, D.; Lanos, Ch.; Jauberthie, R.; Redjel, B.

    2004-11-01

    Le stockage de produits chimiques dans du béton présente souvent des problèmes de durabilité dus aux attaques chimiques. Inévitablement les concentrations élevées sont les plus dangereuses. Le but de notre étude est de déterminer les changements de phases qui apparaissent dans le béton lorsqu'on substitue une partie du ciment par du laitier de haut fourneaux. Les échantillons sont conservés dans des solutions acides différents anions (HCl, H{2}SO{4}, H{3}PO{4} et CH{3}COOH) et différentes concentrations (0,1; 0,25 et 0,5M). Les formations qui apparaissent sont déterminées par diffraction X et observées au MEB. Les solutions sulfatiques conduisent à une formation de gypse en surface et d'ettringite au contact de la matrice cimentaire. Avec l'acide acétique, il y a formation de calcium acétate hydrate sous forme spongieuse tandis que, avec l'acide phosphatique, la formation de calcium hydrogeno phosphate hydrate est très superficielle. Enfin, avec l'acide chlorhydrique, la surface du mortier est recouverte de chlorure de calcium dihydrate et d'hydroxyde de fer. Les résistances mécaniques sont plus ou moins affectées par la concentration mais aussi et surtout par la nature des acides avec dans l'ordre le plus agressif H{2}SO{4} puis HCl et CH{3}COOH enfin peu de modification pour H{3}PO{4}.

  10. Transfer of Learning: Planning Effective Workplace Education Programs = Transfert d'apprentissage: La Planification de programmes d'education efficaces en milieu de travail.

    ERIC Educational Resources Information Center

    Taylor, Maurice

    Given the centrality of the topic of transfer of learning to so many areas of workplace education, this discussion paper (in both English and French versions) draws together research results and practical techniques to help practitioners in the field. Part 1 defines transfer of learning. Part 2 describes factors that influence the transfer of…

  11. The Moral Milieu of Information Technology: Using Domain and Affordance Theory to Explain Situational and Technological Effects on Ethical IT Decision Making

    ERIC Educational Resources Information Center

    Schilhavy, Richard Arthur Milton

    2012-01-01

    Unethical behavior in the use of IT may result in significant negative impacts on the productivity, profitability, and reputation of the organization. IT exacerbates moral problems through its constant evolution, multi-faceted nature and encroachment into our personal and professional lives. People have difficulty recognizing moral…

  12. L’offre des services de vaccination en milieu urbain, au Cameroun: étude de cas du District de Santé de Djoungolo

    PubMed Central

    Ngomba, Armelle Viviane; Kollo, Basile; Bita, André Fouda; Djouma, Fabrice Nembot; Edengue, Jean Marie; Elongue, Marie Josée; Adiogo, Dieudonné

    2016-01-01

    Introduction Les métropoles camerounaises concentrent un nombre croissant d'enfants cibles, non atteints par les services de vaccination de routine. Méthodes Une étude transversale descriptive, basée sur échantillonnage exhaustif des formations sanitaires légales offrant en routine des services de vaccination a été réalisée dans le district de santé de Djoungolo, (ville de Yaoundé). L'évaluation de l'offre des services de vaccination a été calquée sur l'approche « Atteindre Chaque District ». Résultats Des 70 formations sanitaires ayant participé à l'étude, 3 (4,3%) disposaient d'un micro plan actualisé pour la vaccination de routine. Des 63 (89,4%) formations sanitaires possédant un réfrigérateur fonctionnel, 12 (19,0%) vaccinaient au quotidien en stratégie fixe. Cinquante-sept (81,0%) formations sanitaires ne conduisaient pas des sessions de vaccination en stratégies avancées. La participation des membres de la communauté aux activités de vaccination de routine étaient effective dans 1 aire de santé sur les 12 que compte le district. Une courbe de suivi des couvertures vaccinales correctement renseignée étaient disponible dans 6 (8,5%) formations sanitaires. Conclusion L'approche « Atteindre Chaque District » telle que mise en œuvre dans le district de santé de Djoungolo limite l'atteinte d'un maximum d'enfants cibles. L'effectivité d'une micro planification réaliste, la régularité des sessions de vaccination en stratégie fixes et avancées, le suivi des données orienté vers l'action, la redynamisation communautaire en faveur de la vaccination sont des voies d'amélioration des prestations des services de vaccination, dans ce district. PMID:28292168

  13. La detection des cyanobacteries en milieu lacustre par l'etude des anomalies des spectres de reflectance de l'eau

    NASA Astrophysics Data System (ADS)

    Constantin, Gabriel

    Proliferation of cyanobacteria is a growing problem in lacustrine environment that results in rapid degradation of water quality. Moreover, certain cyanobacteria species produce harmful toxins. Phycocyanin (PC) is a photosynthetic pigment typical of cyanobacteria and affects the water color: it is therefore possible to study them using remote sensing. At least three algorithms to estimate PC concentration ([PC]) have been published, but their relative errors are important, especially for lower concentration. In this study, we are presenting the results of a new algorithm that uses the second order variability (anomalies) of water's reflectance spectrum to estimate [PC]. This method has never been used in lacustrine environment. The dataset used to develop and validate the algorithm was obtained between 2001 and 2005 in 57 different lakes and reservoirs of the Netherlands and Spain. The performance of the second order algorithm is equivalent or better than the three previously published algorithms. For the subset were [PC] > 32 mg m-3, the contribution of the second order term (R2=0.68 and RMSE=0.25) seems to improve considerably the first order algorithm (R2=0.50 and RMSE=0.35). The accuracy of the second order algorithm for [PC] > 32 mg m-3 is superior to the one calculated for the whole dataset (R2=0.69 and RMSE=0.44). The algorithm can also be adapted to the. bands of satellite sensor MERIS for the study of cyanobacteria. The application of this algorithm to a MERIS image acquired the 29 August 2010 taken over the Missisquoi Bay (Quebec, Canada) demonstrates the potential of this new algorithm for a future cyanobacteria' monitoring system. Note that all the statistical results presented above are for the logarithm of [PC] and the units of the RMSE are log(mg/m 3).

  14. Le langage en milieu scolaire--Quelques aspects de l'echange maitre-eleves (Language in Academic Surroundings--Some Aspects of Exchange between Students and Teachers)

    ERIC Educational Resources Information Center

    Jones, Rhian

    1977-01-01

    A description of a study whose object was to analyze the oral language used in class by nine-year-olds from varied socioeconomic backgrounds. The procedure, results and the linguistic characteristics according to situation are described. Several statistical tables are provided. (Text is in French.) (AMH)

  15. Connaissance et utilisation des deux langues en milieu partiellement bilingue (Knowledge and Use of Two Languages in a Partially Bilingual Situation).

    ERIC Educational Resources Information Center

    Enparantza, Jose Luis Alvarez

    A study of the difference between knowledge and use of two languages by bilinguals in a partially bilingual situation looks at what is known about language knowledge and language usage, the linguistic and communication tensions affecting monolinguals in a community, some special cases, and the possibilities for diachronic analysis of language…

  16. Recherches Sur La Psychologie de L'enfant de Milieu Defavorise. Rapport- synthese. (Research Relating to the Psychology of the Child in Disadvantaged Environments. Summary Report).

    ERIC Educational Resources Information Center

    Caouette, Charles E.; Bourbeau, Gerald

    Thirteen doctoral dissertations and five masters theses are summarized in this report of research on the disadvantaged child. Contained in each individual summary are the detailed descriptions of the experimental task, the results obtained and the analysis of these results. The eighteen individual theses are concerned with topics such as:…

  17. Spirulina lipopolysaccharides inhibit tumor growth in a Toll-like receptor 4-dependent manner by altering the cytokine milieu from interleukin-17/interleukin-23 to interferon-γ

    PubMed Central

    Okuyama, Hiromi; Tominaga, Akira; Fukuoka, Satoshi; Taguchi, Takahiro; Kusumoto, Yutaka; Ono, Shiro

    2017-01-01

    Th17 cells and the cytokine they produce, interleukin (IL)-17, play an important role in tumor progression in humans and in mice. IL-6 and IL-23 are critical cytokines for the differentiation and propagation of Th17 cells, respectively. Bacterial lipopolysaccharides (LPS) are known to stimulate immune cells to produce such inflammatory cytokines. Contrary to Escherichia coli (E. coli) LPS, LPS from Spirulina has low toxicity and barely induces in vivo production of IL-6 and IL-23 in mice. We examined the antitumor effects of Spirulina LPS compared to E. coli LPS in an MH134 hepatoma model. Administration of Spirulina LPS suppressed tumor growth in C3H/HeN mice, but not in Toll-like receptor 4 (TLR4)-mutant C3H/HeJ mice, by reducing serum levels of IL-17 and IL-23, while increasing interferon (IFN)-γ levels. The antitumor activity and IFN-γ production were mediated by T cells. Moreover, in vitro experiments showed that Spirulina LPS impaired the antigen-presenting function that supports the generation of IL-17-producing cells in a toll-like receptor (TLR)4-dependent manner. Of note, injection of anti-IL-17 antibody in tumor-bearing C3H/HeN mice in the absence of Spirulina LPS markedly suppressed tumor growth and augmented IFN-γ responses. Thus, our results support the notion that IFN-γ and IL-17/IL-23 mutually regulate Th17 and Th1 responses in tumor-bearing hosts, and Spirulina LPS modulates the balance of the IFN-γ-IL-17/IL-23 axis towards IFN-γ production, which leads to tumor inhibition. Furthermore, Spirulina LPS effectively inhibited the spontaneous development of mammary tumors. This study has important implications for the exploitation of TLR-based immunomodulators for cancer immunotherapy. PMID:28075473

  18. Transmission quantique de clés de cryptage en milieu aérien par codage en phase de bandes latérales de modulation

    NASA Astrophysics Data System (ADS)

    Marc, M.; Mérolla, J.-M.; Durrafourg, L.; Goedgebuer, J.-P.; Rhodes, W. T.

    2002-06-01

    L'étude présentée concerne un procédé de distribution quantique de clés de cryptage utilisant des états cohérents et la mise au point d'un système de transmission aérien. Le système de cryptage exploite les propriétés d'interférence à un photon dans deux bandes latérales de modulation, qui contiennent chacune en moyenne 0,1 photon. Les probabilités de détecter un photon dans chacune des bandes de modulation varient de façon complémentaire en fonction du déphasage induit entre l'émetteur et le récepteur. Cette méthode permet d'exploiter le protocole à 4 états de distribution de clé.

  19. Consequences experimentales des effets des fluctuations du vide sur la fluorescence parametrique et la generation du second harmonique en milieu confine

    NASA Astrophysics Data System (ADS)

    Robichaud, Luc

    Les fluctuations du vide, qui consistent en l'apparition momentanee de particules, ce qui est permit par le principe d'incertitude de Heisenberg, joue un role primordial dans les processus photoniques, en particulier les processus non-lineaires. Par la manipulation de ces fluctuations du vide a l'aide de confinement optique, on retrouve deux phenomenes particuliers : l'intensification de la fluorescence parametrique (Walker, 2008) et l'inhibition de la generation du second harmonique (Collette, 2013). Dans ce travail, on presente les resultats dans le cas classique ; c'est-a-dire sans fluctuations du vide et confinement. Par la suite, on presente les effets des fluctuations du vide et du confinement, ce qui mene aux deux effets mentionnes. Dans le cas de la fluorescence parametrique, le bruit quantique sur le champ interne et externe est calcule, le role du desaccord de phase dans le modele est expose et une generalisation tridimensionnelle est etudiee afin de generaliser la conception du modele d'un cas unidimensionnel a un cas tridimensionnel planaire. Dans le cas de la generation du second harmonique, les difficultes d'un modele purement tridimensionnel sont exposees et ensuite le cas limite planaire est etudie.

  20. PolyICLC Exerts Pro- and Anti-HIV Effects on the DC-T Cell Milieu In Vitro and In Vivo

    PubMed Central

    Hallor, Magnus; Singer, Rachel; Tharinger, Hugo; Kenney, Jessica; Gettie, Agegnehu; Grasperge, Brooke; Blanchard, James; Salazar, Andres; Lifson, Jeffrey D.; Robbiani, Melissa; Derby, Nina

    2016-01-01

    Myeloid dendritic cells (mDCs) contribute to both HIV pathogenesis and elicitation of antiviral immunity. Understanding how mDC responses to stimuli shape HIV infection outcomes will inform HIV prevention and treatment strategies. The long double-stranded RNA (dsRNA) viral mimic, polyinosinic polycytidylic acid (polyIC, PIC) potently stimulates DCs to focus Th1 responses, triggers direct antiviral activity in vitro, and boosts anti-HIV responses in vivo. Stabilized polyICLC (PICLC) is being developed for vaccine adjuvant applications in humans, making it critical to understand how mDC sensing of PICLC influences HIV infection. Using the monocyte-derived DC (moDC) model, we sought to describe how PICLC (vs. other dsRNAs) impacts HIV infection within DCs and DC-T cell mixtures. We extended this work to in vivo macaque rectal transmission studies by administering PICLC with or before rectal SIVmac239 (SIVwt) or SIVmac239ΔNef (SIVΔNef) challenge. Like PIC, PICLC activated DCs and T cells, increased expression of α4β7 and CD169, and induced type I IFN responses in vitro. The type of dsRNA and timing of dsRNA exposure differentially impacted in vitro DC-driven HIV infection. Rectal PICLC treatment similarly induced DC and T cell activation and pro- and anti-HIV factors locally and systemically. Importantly, this did not enhance SIV transmission in vivo. Instead, SIV acquisition was marginally reduced after a single high dose challenge. Interestingly, in the PICLC-treated, SIVΔNef-infected animals, SIVΔNef viremia was higher, in line with the importance of DC and T cell activation in SIVΔNef replication. In the right combination anti-HIV strategy, PICLC has the potential to limit HIV infection and boost HIV immunity. PMID:27603520

  1. [Value of bony resection-reconstruction by avascular autologous fibular graft in the tropical milieu. Treatment of a giant cavernous hemangioma of the humerus].

    PubMed

    Thiery, J F; Martet, G; Lemesle, L; Vaujany, P; Escarment, J; Merrien, Y

    1994-01-01

    In a poorly equipped tropical setting, limb amputation is often considered as the only therapeutic solution for malignant tumors or large benign tumors. However it can be avoided by bone replacement using an avascular autologous fibular graft. This method was used in a young girl from Tchad presenting a giant cavernous hemangioma of the humerus. This technique allowed salvage of the extremity but resulted inevitably in radial paralysis. The time needed for bone healing was normal. This technique required minimum facilities and was perfectly biocompatible. It can be used in tropical settings where allograft techniques and prosthetic replacement are not available.

  2. Effect of brain-derived neurotrophic factor on mesenchymal stem cell-seeded electrospinning biomaterial for treating ischemic diabetic ulcers via milieu-dependent differentiation mechanism.

    PubMed

    He, Siyi; Shen, Lei; Wu, Yangxiao; Li, Li; Chen, Wen; Hou, Chunli; Yang, Mingcan; Zeng, Wen; Zhu, Chuhong

    2015-03-01

    Great challenges in transplantation of mesenchymal stem cells (MSCs) for treating ischemic diabetic ulcers (IDUs) are to find a suitable carrier and create a beneficial microenvironment. Brain-derived neurotrophic factor (BDNF), a member of neurotrophin family, is considered angiogenic and neuroprotective. Given that IDUs are caused by vascular disease and peripheral neuropathy, we used BDNF as a stimulant, and intended to explore the role of new biomaterials complex with MSCs in wound healing. BDNF promoted the proliferation and migration of MSCs using MTT, transwell, and cell scratch assays. The activity of human umbilical vein endothelial cells (HUVECs) was also enhanced by the MSC-conditioned medium in the presence of BDNF, via a vascular endothelial growth factor-independent pathway. Since proliferated HUVECs in the BDNF group made the microenvironment more conducive to endothelial differentiation of MSCs, by establishing co-culture systems with the two cell types, endothelial cells derived from MSCs increased significantly. A new biomaterial made of polylactic acid, silk and collagen was used as the carrier dressing. After transplantation of the BDNF-stimulated MSC/biomaterial complex, the ulcers in hindlimb ischemic mice healed prominently. More blood vessel formation was observed in the wound tissue, and more MSCs were co-stained with some endothelial-specific markers such as cluster of differentiation (CD)31 and von Willebrand Factor (vWF) in the treatment group than in the control group. These results demonstrated that BDNF could improve microenvironment in the new biomaterial, and induce MSCs to differentiate into endothelial cells indirectly, thus accelerating ischemic ulcer healing.

  3. Bildung und Soziales Milieu: Determinanten des Lebenslangen Lernens in Einer Metropole (Education and Social Environment: Determinants of Life-Long Learning in a Metropolis).

    ERIC Educational Resources Information Center

    Barz, Heiner; Tippelt, Rudolf

    2003-01-01

    Describes the research on lifelong learning. Presents results of an empirical study analyzing the interest in further education of selected social environments in a large city (Munich, Germany). Concludes that the age of learners and their educational level strongly influences the concrete process of education and lifetime learning. (CAJ)

  4. Spirulina lipopolysaccharides inhibit tumor growth in a Toll-like receptor 4-dependent manner by altering the cytokine milieu from interleukin-17/interleukin-23 to interferon-γ.

    PubMed

    Okuyama, Hiromi; Tominaga, Akira; Fukuoka, Satoshi; Taguchi, Takahiro; Kusumoto, Yutaka; Ono, Shiro

    2017-02-01

    Th17 cells and the cytokine they produce, interleukin (IL)-17, play an important role in tumor progression in humans and in mice. IL-6 and IL-23 are critical cytokines for the differentiation and propagation of Th17 cells, respectively. Bacterial lipopolysaccharides (LPS) are known to stimulate immune cells to produce such inflammatory cytokines. Contrary to Escherichia coli (E. coli) LPS, LPS from Spirulina has low toxicity and barely induces in vivo production of IL-6 and IL-23 in mice. We examined the antitumor effects of Spirulina LPS compared to E. coli LPS in an MH134 hepatoma model. Administration of Spirulina LPS suppressed tumor growth in C3H/HeN mice, but not in Toll-like receptor 4 (TLR4)-mutant C3H/HeJ mice, by reducing serum levels of IL-17 and IL-23, while increasing interferon (IFN)-γ levels. The antitumor activity and IFN-γ production were mediated by T cells. Moreover, in vitro experiments showed that Spirulina LPS impaired the antigen-presenting function that supports the generation of IL-17-producing cells in a toll-like receptor (TLR)4-dependent manner. Of note, injection of anti-IL-17 antibody in tumor-bearing C3H/HeN mice in the absence of Spirulina LPS markedly suppressed tumor growth and augmented IFN-γ responses. Thus, our results support the notion that IFN-γ and IL-17/IL-23 mutually regulate Th17 and Th1 responses in tumor-bearing hosts, and Spirulina LPS modulates the balance of the IFN-γ-IL-17/IL-23 axis towards IFN-γ production, which leads to tumor inhibition. Furthermore, Spirulina LPS effectively inhibited the spontaneous development of mammary tumors. This study has important implications for the exploitation of TLR-based immunomodulators for cancer immunotherapy.

  5. Who were his peers? The social and professional milieu of the provincial surgeon-apothecary in the late-eighteenth century.

    PubMed

    Tomkins, Alannah

    2011-01-01

    The social standing of the surgeon-apothecary cannot be determined by reference to professional life alone, yet few such men left social documents. The lower middling sort was typically reticent about evaluations of their own social position in any source genre. This article uses a unique archive, and the concept of community connectedness, to investigate the status of Thomas Higgins, surgeon-apothecary and man-midwife of north Shropshire. Higgins embodied the traditional practitioner who relied on local knowledge and his 'friends' for advancement, in contrast to alternative modes of rising professionalism. He was demonstrably a trusted man at the heart of his home town, but his reliance on the 'partiality' of his neighbors brought him into conflict with his colleagues.

  6. Failure to establish and maintain a pregnancy in undernourished recipient ewes is associated with a poor endocrine milieu in the early luteal phase.

    PubMed

    de Brun, Victoria; Meikle, Ana; Fernández-Foren, Andrea; Forcada, Fernando; Palacín, Inmaculada; Menchaca, Alejo; Sosa, Cecilia; Abecia, José-Alfonso

    2016-10-01

    Embryos from undernourished and control donor ewes were transferred to undernourished and control recipient ewes. Progesterone and metabolic hormones were investigated in recipient ewes to determine their association with pregnancy success. Forty-five donor and 52 recipient Rasa Aragonesa ewes were fed 1.5 (control group; donor n=20; recipient n=25) or 0.5 (low group; donor n=25; recipient n=27) times the daily requirements for maintenance from the onset of estrous synchronization treatment to embryo collection and transfer. The embryos were collected 7days after the onset of estrus (day 0), and two good-quality embryos were transferred into each recipient ewe. The percentage of pregnant ewes on day 18 and 40 did not differ between the two groups, although the recipient undernourished ewes tended to have greater late embryonic mortality (from days 18-40) than the control recipient ewes (P=0.11). No effect of the nutrition of the donor was found. Recipients that became pregnant had a higher ovulation rate than non-pregnant ewes (P=0.02). Undernourished ewes had lower plasma insulin concentrations than control ewes (P=0.03), and those that suffered late embryo mortality (from days 18-40) tended to have lower insulin and progesterone concentrations than their counterparts that remained pregnant (P=0.06 and P=0.07, respectively). In this study, pregnancy in control and undernourished recipient ewes was not associated with the origin of the embryo (undernourished and control donors). In conclusion, failure to establish and maintain a pregnancy was associated with lower progesterone and insulin levels one week after estrus in recipient ewes.

  7. Surpoids et obésité dans la population au-dessus de 20 ans en milieu urbain bamakois (Mali)

    PubMed Central

    Oumar Bâ, Hamidou; Menta, Ichaka; Camara, Youssouf; Sangaré, Ibrahima; Sidibé, Noumou; Doumbia, Seydou; Diarra, Mamadou Bocary

    2014-01-01

    Introduction Il est question dans notre travail d’étudier le SP et l'OB et les facteurs associés dans la population âgée de 20 ans ou plus. Méthodes Notre échantillon a été obtenu à partir d'une enquête sur les pathologies cardiovasculaires dans le District de Bamako et impliquant 2199 sujets de 5-104 ans, en sélectionnant tous les sujets âgés d'au moins 20 ans (1162). Pour chaque sujet, l'IMC, rapport taille / hanche et le tour de taille ont été déterminées. Les données ont été analysées avec SPSS 12. Résultats L’âge moyen était de 36,86 années, 61,4% étaient des femmes, 49,7% dans le secteur informel et 38,0% avaient réalisé l'enseignement primaire. Facteurs de risque cardiovasculaires étaient l'inactivité physique (72,4%), le tabagisme (12,2%) et hypertension (26,7%). La prévalence de l'obésité était de 8,8 et 14,7% respectivement sur la base de l'indice de masse et le tour de taille. Conclusion Le SP et l'OB sont à prendre en compte dans les mesures de politique sanitaire que dans la pratique quotidienne des professionnels de santé, il est peut-être plus utile d'utiliser plusieurs paramètres pour être à même de bien stratifier nos patients par rapport à leur risque. PMID:25932065

  8. Evidence Molded by Contact with Staff Culture and Patient Milieu: An Analysis of the Social Process of Knowledge Utilization in Nursing Homes

    ERIC Educational Resources Information Center

    Øye, Christine; Mekki, Tone Elin; Skaar, Randi; Dahl, Hellen; Forland, Oddvar; Jacobsen, Frode F.

    2015-01-01

    Knowledge utilization is politically "hot" because it informs decisions on improving the quality of care in nursing homes (NHs). The difficulties encountered in implementing evidence-based knowledge into practice may be explained by contextual factors. Contextual factors are crucial to understanding the process of knowledge utilization;…

  9. Manual on the Flight of Flexible Aircraft in Turbulence (Manuel sur le Vol des Avions Non-rigides en Milieu Turbulent)

    DTIC Science & Technology

    1991-05-01

    consisting of officially appointed senior representatives from each member nation. The mission of AGARD is carried out through the Panels which are ...of AGARD work are reported to the member nations and the NATO Authonties through ihe AGARD series of publications of which this is one. Participation...and due to airplane vertical response motion are present, and that the airplane would move wt,, . o.l alter the load Analysts indicated that these

  10. Prevalence of Antimicrobial Resistant and Virulent Salmonella spp. in Treated Effluent and Receiving Aquatic Milieu of Wastewater Treatment Plants in Durban, South Africa.

    PubMed

    Odjadjare, Ejovwokoghene C; Olaniran, Ademola O

    2015-08-18

    In this study, we evaluated the impact of treated wastewater effluent from two wastewater treatment plants on the physicochemical parameters and Salmonella spp. load of receiving rivers. Presumptive Salmonella spp. were obtained at all sampled points including the discharge points, with counts ranging from 0 to 4.14 log cfu/mL at both plants. Turbidity, chemical and biological oxygen demand were found to be high and mostly above the required limit for treated wastewater discharge. However, recorded nitrate and phosphate values were very low. Of the 200 confirmed Salmonella spp. isolates recovered from the treated effluent and receiving surface waters, 93% harbored the spiC gene, 84% harbored the misL gene, and 87.5% harbored the orfL gene while 87% harbored the pipD gene. The antibiotic resistance profile revealed that the isolates were resistant to sulfamethoxazole, nalidixic acid and streptomycin, but susceptible to quinolones and third generation β-lactams. These results indicate that in South Africa treated effluents are still a major source of contamination of rivers with pathogens such as Salmonella. Appropriate steps by the regulatory authorities and workers at the treatment plants are needed to enforce stipulated guidelines in order to prevent pollution of surface water resources due to the discharge of poorly treated effluents.

  11. In Vivo Effect of Innate Immune Response Modulating Impurities on the Skin Milieu Using a Macaque Model: Impact on Product Immunogenicity.

    PubMed

    Haile, Lydia A; Puig, Montserrat; Polumuri, Swamy K; Ascher, Jill; Verthelyi, Daniela

    2017-03-01

    Unwanted immune responses to therapeutic proteins can severely impact their safety and efficacy. Studies show that the presence of trace amounts of host cells and process-related impurities that stimulate pattern recognition receptors (PRR) can cause local inflammation and enhance product immunogenicity. Here we used purified PRR agonists as model impurities to assess the minimal level of individual innate immune response modulating impurities (IIRMIs) that could activate a local immune response. We show that levels of endotoxin as low as 10 pg (0.01 EU), 1 ng for polyinosinic:polycytidylic acid (PolyI:C), 100 ng for synthetic diacylated liopprotein, thiazoloquinolone compound, or muramyl dipeptide, 1 μg for flagellin or β-glucan, or 5 μg for CpG-oligodeoxynucleotide increased expression of genes linked to innate immune activation and inflammatory processes in the skin of rhesus macaques. Furthermore, spiking studies using rasburicase as a model therapeutic showed that the levels of PRR agonists that induced detectable gene upregulation in the skin were associated with increased immunogenicity for rasburicase. This study underscores the need for testing multiple IIRMIs in biologics, strengthening the connection between the local mRNA induction in skin, innate immune activation, and antibody development in primates, and provides an indication of the levels of IIRMI in therapeutic products that could impact product immunogenicity.

  12. Micellisation et activité de surface des bromures de n-alkyltriméthylammonium en milieu eau-acide orthophosphorique

    NASA Astrophysics Data System (ADS)

    Ouni, S.; Hafiane, A.; Dhahbi, M.

    1998-05-01

    Measurements of superficial tension of n-alkyltrimethylammonium bromides in air/water-orthophosphoric acid interface have been made by “stripping method". Data were evaluated by approximation to the Von Szyszkowski equation. Thermodynamic parameters as (Γmax, F, A, B, Δ G^circ_A, Δ GM and CMC) at different concentrations of orhophosphoric acid (0 at 3 M) are calculted. The CMC values of the homologous series in relation to the chain length were determined. They showed a good correlation with the Klevens equation. A minimum of CMC and (-ΔGM) was observed for the n-octadecyltrimethylammonium bromide, which has been attributed to the cosolvant effect and the change of medium properties. L'adsorption, de bromure de n-alkyltriméthylammonium à l'interface air/eau-acide orthophosphorique, a été étudiée par la mesure de tension superficielle en fonction du nombre d'atomes de carbone du groupement alkyle et de la concentration en acide orthophosphorique (0 à 3 M). L'analyse des résultats a été effectuée à l'aide de l'équation de Von Szyszkowski. Les grandeurs et paramètres thermodynamiques (Γmax, F, A, B, Δ G^circ_A, Δ GM and CMC) ont été déterminés et discutés selon l'équilibre de forces de répulsion électrostatique entre les têtes polaires et d'attraction hydrophobe des chaînes aliphatiques. Les valeurs des CMC obéissent à l'équation de Klevens. Dans le cas du bromure de n-octadécyltriméthylammonium les valeurs de la CMC et de (-ΔGM) présentent un minimum, attribué au changement des propriétés du binaire eau-acide orthophosphorique.

  13. Prevalence of Antimicrobial Resistant and Virulent Salmonella spp. in Treated Effluent and Receiving Aquatic Milieu of Wastewater Treatment Plants in Durban, South Africa

    PubMed Central

    Odjadjare, Ejovwokoghene C.; Olaniran, Ademola O.

    2015-01-01

    In this study, we evaluated the impact of treated wastewater effluent from two wastewater treatment plants on the physicochemical parameters and Salmonella spp. load of receiving rivers. Presumptive Salmonella spp. were obtained at all sampled points including the discharge points, with counts ranging from 0 to 4.14 log cfu/mL at both plants. Turbidity, chemical and biological oxygen demand were found to be high and mostly above the required limit for treated wastewater discharge. However, recorded nitrate and phosphate values were very low. Of the 200 confirmed Salmonella spp. isolates recovered from the treated effluent and receiving surface waters, 93% harbored the spiC gene, 84% harbored the misL gene, and 87.5% harbored the orfL gene while 87% harbored the pipD gene. The antibiotic resistance profile revealed that the isolates were resistant to sulfamethoxazole, nalidixic acid and streptomycin, but susceptible to quinolones and third generation β-lactams. These results indicate that in South Africa treated effluents are still a major source of contamination of rivers with pathogens such as Salmonella. Appropriate steps by the regulatory authorities and workers at the treatment plants are needed to enforce stipulated guidelines in order to prevent pollution of surface water resources due to the discharge of poorly treated effluents. PMID:26295245

  14. L'ilot du reservoir: etude de voisinage en milieu urbain (The Reservoir Block: A Study of a Neighborhood in an Urban Setting).

    ERIC Educational Resources Information Center

    Rey, Jean-Noel

    1983-01-01

    An analysis of a small neighborhood of Paris looks at its layout and spatial constraints, habitats, symbols, sense of territory, and rhythms and styles of the inhabitants and their roles in the group. The description, including photos, is intended for use in the French language classroom. (MSE)

  15. Examining Mandated Testing, Teachers' Milieu, "and" Teachers' Knowledge and Beliefs: Gaining a Fuller Understanding of the Web of Influence on Teachers' Classroom Practices

    ERIC Educational Resources Information Center

    Neumann, Jacob W.

    2016-01-01

    Background: Much research has been done on the factors that influence teachers' work. Yet, the nature and scope of those factors, and their impact on teachers, remain unclear. Indeed, different literature bases on teachers' work present different and often contradictory conclusions. For example, some researchers claim that mandated accountability…

  16. Studying Hostile, Deceptive, and Dangerous Surroundings: Report of a Workshop on Social Research Methods for Non-Permissive Environments (Etudier des Milieux Hostiles, Trompeurs et Dangereux - Rapport Concernant un Atelier sur les Methodes de Recherche Sociale an Milieu non Permissif)

    DTIC Science & Technology

    2010-08-01

    peuvent aider à fournir un cadre plus complet pour ces microcosmes, et identifient également des individus et des entreprises avec des implications... financing , and other security threats. Information is gathered through mandated regulatory reporting from banks and financial institutions. When...for anti-terrorism than the money laundering model of the Global Finance Forum (GFF) because the money laundering model is focused on the money

  17. Low and moderate doses of ionizing radiation up to 2 Gy modulate transmigration and chemotaxis of activated macrophages, provoke an anti-inflammatory cytokine milieu, but do not impact upon viability and phagocytic function.

    PubMed

    Wunderlich, R; Ernst, A; Rödel, F; Fietkau, R; Ott, O; Lauber, K; Frey, B; Gaipl, U S

    2015-01-01

    Benign painful and inflammatory diseases have been treated for decades with low/moderate doses of ionizing radiation (LD-X-irradiation). Tissue macrophages regulate initiation and resolution of inflammation by the secretion of cytokines and by acting as professional phagocytes. Having these pivotal functions, we were interested in how activated macrophages are modulated by LD-X-irradiation, also with regard to radiation protection issues and carcinogenesis. We set up an ex-vivo model in which lipopolysaccharide pre-activated peritoneal macrophages (pMΦ) of radiosensitive BALB/c mice, mimicking activated macrophages under inflammatory conditions, were exposed to X-irradiation from 0·01 Gy up to 2 Gy. Afterwards, the viability of the pMΦ, their transmigration and chemotaxis, the phagocytic behaviour, the secretion of inflammatory cytokines and underlying signalling pathways were determined. Exposure of pMΦ up to a single dose of 2 Gy did not influence their viability and phagocytic function, an important fact regarding radiation protection. However, significantly reduced migration, but increased chemotaxis of pMΦ after exposure to 0·1 or 0·5 Gy, was detected. Both might relate to the resolution of inflammation. Cytokine analyses revealed that, in particular, the moderate dose of 0·5 Gy applied in low-dose radiotherapy for inflammatory diseases results in an anti-inflammatory cytokine microenvironment of pMΦ, as the secretion of the proinflammatory cytokine interleukin (IL)-1β was reduced and that of the anti-inflammatory cytokine transforming growth factor (TGF)-β increased. Further, the reduced secretion of IL-1β correlated with reduced nuclear translocation of nuclear factor (NF)-κB p65, starting at exposure of pMΦ to 0·5 Gy of X-irradiation. We conclude that inflammation is modulated by LD-X-irradiation via changing the inflammatory phenotype of macrophages.

  18. Assessment of physicochemical parameters and prevalence of virulent and multiple-antibiotic-resistant Escherichia coli in treated effluent of two wastewater treatment plants and receiving aquatic milieu in Durban, South Africa.

    PubMed

    Pillay, Leanne; Olaniran, Ademola O

    2016-05-01

    The poor operational status of some wastewater treatment plants often result in the discharge of inadequately treated effluent into receiving surface waters. This is of significant public health concern as there are many informal settlement dwellers (ISDs) that rely on these surface waters for their domestic use. This study investigated the treatment efficiency of two independent wastewater treatment plants (WWTPs) in Durban, South Africa and determined the impact of treated effluent discharge on the physicochemical and microbial quality of the receiving water bodies over a 6-month period. Presumptive Escherichia coli isolates were identified using biochemical tests and detection of the mdh gene via PCR. Six major virulence genes namely eae, hly, fliC, stx1, stx2, and rfbE were also detected via PCR while antibiotic resistance profiles of the isolates were determined using Kirby-Bauer disc diffusion assay. The physicochemical parameters of the wastewater samples ranged variously between 9 and 313.33 mg/L, 1.52 and 76.43 NTUs, and 6.30 and 7.87 for COD, turbidity, and pH respectively, while the E. coli counts ranged between 0 and 31.2 × 10(3) CFU/ml. Of the 200 selected E. coli isolates, the hly gene was found in 28 %, fliC in 20 %, stx2 in 17 %, eae in 14 %, with stx1 and rfbE in only 4 % of the isolates. Notable resistance was observed toward trimethoprim (97 %), tetracycline (56 %), and ampicillin (52.5 %). These results further highlight the poor operational status of these WWTPs and outline the need for improved water quality monitoring and enforcement of stringent guidelines.

  19. Comprendre le processus d'adaptation des demarches d'enseignement en classe de sciences et technologies a l'ecole secondaire: Analyse des besoins percus par les personnes enseignantes en milieu defavorise

    NASA Astrophysics Data System (ADS)

    Houde, Sylvie

    Since the implementation of the latest reform in the education programs of Quebec, the adaptation of teaching has taken on an important place in the concerns of all actors in education. However, this adjustment towards the adoption of teaching practices that require more participation on the part of the pupil is not accomplished so easily, particularly in the field of science and technology (ST). In order to gain a better understanding of these processes of adaptation, it is opportune to question ourselves on the factors and dynamics of interest at stake, especially in disadvantaged environments. Such environments are faced with situations where other difficulties coexist: integration of pupils, lack of interest, problems in classroom management, multi-ethnicity, etc. As a result, such difficulties give rise to particular limitations, expressed in the form of needs, by pupils and teachers, likely to have a restrictive effect on the adaptation of teaching practices. Accordingly, our research focuses on the needs perceived by teachers in high school ST classrooms in disadvantaged school environments, since they present a privileged means to better understand the processes involved in the adaptation of practices. The adoption of an ecosystemic perspective, centered on these needs and their contribution towards the dynamics of decision-making, enabled us to better apprehend the complexity of these processes in ST classrooms. We were able to identify the needs perceived by teachers by following the methodology of conceptanalysis of needs, and by combining focus groups with the DRAP software. The results account for the large variety of needs to be considered in the equation of adaptation of teaching practices. These needs generally belong to the classroom system (microsystem). For pupils, they are mainly cognitive needs, but for teachers, they pertain to organization and structure. The influence of these needs on the adaptation processes depends on the interpretation by teachers of teaching situations, so much so that a same need can at times be assumed as negative pressure, generating obstacles, or at other times as a positive impulse, facilitating adaptation. Keywords: teaching practices; science and technology education; high school education; adaptation processes; needs assessment; disadvantaged environments.

  20. Utilite des images de radar aeroporte en bande C pour l'evaluation du stade de croissance de la canne a sucre et des cultures maraicheres en milieu tropical, dans une optique de conservation des sols

    NASA Astrophysics Data System (ADS)

    Beaulieu, Nathalie Lucie

    1998-12-01

    This study aims at determining how images from an airborne Synthetic Aperture Radar System, in C-band and with two polarisation configurations, can help evaluate the degree of protection offered to soils by vegetation against erosion in tropical areas. With the objective of supplying information to improve the planning of images from the RADARSAT satellite for soil conservation projects, the study aims at establishing which incident angles and which climatic conditions improve contrasts between bare and protected soils. The study encompasses three sites in Costa Rica. Two of them are located in the central cordillera, in mountainous terrain: the Tierra Blanca site where root crops dominate, and the Juan Vinas site where sugar cane is cultivated. The images have been prepared to allow the quantitative analysis of radar backscattering. The first stage of the analysis compares the discriminating capacities of images acquired on each site with different incident angles and polarisations. In general, the backscattering coefficient of crops has shown a lower tendency to diminish in function of local incident angle than that of bare soil. Results suggest that for sugar cane in relatively dry conditions, it is possible to distinguish plots of bare soil from vegetated ones on the basis of their average backscattering coefficient, except for very high incident angles (higher than 73°). The second part of the analysis treats of the complementarity of the HH and VV polarisations and of images acquired with different incident angles. From the results of this study, we can draw recommendations for the acquisition of RADARSAT images even if the images studied here present a higher spatial resolution and higher incident angles, in many cases. Higher incident angles are recommended because they enhance contrasts between bare soil plots and vegetated ones. The very high incident angles at which we observed the opposite effect are not attainable with satellite radars. Relief causes important radiometric variations that must be corrected in order to appreciate the variations caused by changes in land cover. The correction method developed here can also be applied to satellite radar images. Its approach is to calculate the backscattering coefficient for a reference terrain that is flat, perfectly rough (producing isotropic backscattering) with the elevation considered for calibration, supposing that the studied terrain is also perfectly rough. (Abstract shortened by UMI.)

  1. Représentativité de l'échantillonnage géochimique et hydrodynamique en nappe libre du milieu semi-aride (Reliability of geochemical and hydrodynamic sample in a semi-arid water table)

    NASA Astrophysics Data System (ADS)

    Favreau, G.; Leduc, C.; Marlin, C.

    2000-11-01

    This paper evaluates the reliability of the geochemical and hydrodynamic sampling in a phreatic aquifer of semi-arid Africa. These remarks are based on a dense network and on detailed data collected for about ten years in the Continental Terminal water table near Niamey, Niger. The natural potentiometric fluctuations are seasonal (up to 6 m during the rainy season) and interannual (up to 10 m since the 1960s). Hydrodynamic measurements can be disturbed by artificial flooding into the wells (20% of the network) and by domestic drawings (up to 2 m of lowering). Geochemical characteristics can vary seasonally: isotopic modifications and salinity increase near recharge areas, with more stability further away. They can also vary artificially in wells because of their large opening towards the open air. Artifical increases of salinity of one order of magnitude and contaminations of 14C activities of up to 20 pmC occur in some wells by atmospheric dust inputs or organic matter which was has fallen into the well. In conclusion, some recommendations are given for a representative sampling in semi-arid phreatic aquifers.

  2. La qualite des services de garde en milieu scolaire: relation avec la formation et l'experience du personnel (Relationship between the Quality of School-Age Child Care and Training and Experience of Staff).

    ERIC Educational Resources Information Center

    Baillargeon, Madeleine; Larouche, Helene; Roy, Chantal

    1999-01-01

    Investigated the relationship between the quality of after-school child care programs in Quebec and the education and experience of staff. Based on questionnaire responses of teachers and administrators, 26 programs were rated using the School-Age Care Environment Rating Scale. Found correlations between program directors' experience and program…

  3. Novel Perspectives in Redox Biology and Pathophysiology of Failing Myocytes: Modulation of the Intramyocardial Redox Milieu for Therapeutic Interventions—A Review Article from the Working Group of Cardiac Cell Biology, Italian Society of Cardiology

    PubMed Central

    Arcaro, Alessia; Pirozzi, Flora; Angelini, Annalisa; Chimenti, Cristina; Crotti, Lia; Giordano, Carla; Mancardi, Daniele; Torella, Daniele; Tocchetti, Carlo G.

    2016-01-01

    The prevalence of heart failure (HF) is still increasing worldwide, with enormous human, social, and economic costs, in spite of huge efforts in understanding pathogenetic mechanisms and in developing effective therapies that have transformed this syndrome into a chronic disease. Myocardial redox imbalance is a hallmark of this syndrome, since excessive reactive oxygen and nitrogen species can behave as signaling molecules in the pathogenesis of hypertrophy and heart failure, leading to dysregulation of cellular calcium handling, of the contractile machinery, of myocardial energetics and metabolism, and of extracellular matrix deposition. Recently, following new interesting advances in understanding myocardial ROS and RNS signaling pathways, new promising therapeutical approaches with antioxidant properties are being developed, keeping in mind that scavenging ROS and RNS tout court is detrimental as well, since these molecules also play a role in physiological myocardial homeostasis. PMID:26881035

  4. Consultation on Workplace Literacy (Ottawa, Ontario, Canada, June 11-12, 1997). A Report = Consultation sur l'Alphabetisation en Milieu de Travail (Ottawa, Ontario, Canada, 11-12 juin 1997). Rapport.

    ERIC Educational Resources Information Center

    National Literacy Secretariat, Ottawa (Ontario).

    This report describes a meeting of Canadian partners who had experience in workplace literacy and represented different sectors that was convened to develop two lists of priorities for possible projects--those of interest to all sectors and of interest to each sector. Participants identified six clusters of priorities across Canada:…

  5. Croyances des Futurs Enseignants at L'Utilisation des Technologies de L'Information en Milieu Scholaire. (The Beliefs of Future Teachers About the Utilization of Information Technology in Schools.)

    ERIC Educational Resources Information Center

    IsaBell, Claire; Desjardin, Richard; Desjardins, Yvon

    2001-01-01

    Studies the attitudes of student teachers concerning integration of information technologies and communications (ITC) in school settings. Suggests that the motivation of these teachers is essential for ensuring the integration of microcomputers into the educational environment. Finds that, based on a research study, student teachers expressed…

  6. Effet paradoxal du vieillissement sur des tâches de mémoire prospective time-based en situation de laboratoire et en milieu naturel : Rôle des fonctions exécutives.

    PubMed

    Azzopardi, Barbara; Auffray, Caroline; Kermarrec, Christophe

    2017-03-01

    The current study investigates the specific role of three executive functions in the explanation of performance variability on laboratory and naturalistic time-based prospective memory tasks in aging. Ninety people aged 18 to 80 years performed three executive tasks assessing inhibition, flexibility and updating, one laboratory time-based task and one naturalistic time-based task. The results indicate that age has a negative impact on the laboratory time-based task and a positive impact on the naturalistic task. The mediation analysis shows that inhibition and flexibility operate as a mediator in the negative relationship between age and the laboratory time-based task. Additionally, the hierarchical regression analyses show that, after controlling for age, none of the executive functions evaluated is predictive of performance of the naturalistic time-based task. Overall, these results seem to suggest that different cognitive processes underlie the performance on naturalistic and on laboratory time-based tasks. Future studies should confirm these results.

  7. Étude expérimentale du dépôt de particules colloïdales en milieu poreux : Influence de l'hydrodynamique et de la salinité

    NASA Astrophysics Data System (ADS)

    Djehiche, Abdelkader; Canseco, Vladimir; Omari, Aziz; Bertin, Henri

    2009-09-01

    This study deals with colloid transport in porous media which applications are found in subsurface water, petroleum engineering or civil engineering. An experimental study of colloidal polystyrene Latex particles deposition in a consolidated porous medium is presented. The influence of ionic strength of the colloid suspension and the flow rate on particle deposition is investigated. We see first that beyond a critical salt concentration, the total collector efficiency increases with the ionic strength. Moreover, such collector efficiency decreases as the flow rate increases according to theory. In other respects, using a γ ray attenuation technique allows us to measure local porosity fluctuation due to particles deposition. By this way deposition kinetics may be followed locally and precisely. Nevertheless when considering the thickness of the adsorbed layer over large scales, obtained results using the γ rays attenuation technique are found in good agreement with those obtained by means of an usual technique especially at latest stages of adsorption process. To cite this article: A. Djehiche et al., C. R. Mecanique 337 (2009).

  8. Apoptosis, DAP-Kinase1 Expression and the Influences of Cytokine Milieu and Mesenchymal Stromal Cells on Ex Vivo Expansion of Umbilical Cord Blood-Derived Hematopoietic Stem Cells.

    PubMed

    Amirizadeh, Naser; Oodi, Arezoo; Mehrasa, Roya; Nikougoftar, Mahin

    2016-03-01

    Expansion of umbilical cord blood-derived CD34(+) cells can potentially provide them in numbers sufficient for clinical applications in adult humans. In this study apoptosis rate of expanded cells, mRNA expression and promoter methylation status of DAPK1 were evaluated during cord blood hematopoietic stem cell (CB-HSC) ex vivo expansion using cytokines and a co-culture system with mesenchymal stromal cells (MSCs). Ex vivo cultures of CB-HSCs were performed in three culture conditions for 14 days: cytokines with MSCs feeder layer, cytokines without MSCs feeder layer and co-culture with MSCs feeder layer without cytokine. Total number of cells, CD34(+) cells and colony forming unit assay were performed during expansion. Flow cytometric analysis by propidium iodide was performed to detection of apoptosis rate in expanded cells. Methylation status of the DAPK1 gene promoter was analyzed using methylation specific PCR, and DAPK1 mRNA expression was evaluated by real time-PCR. Maximum CB-CD34(+) cells expansion was observed in day 10 of expansion. The highest apoptosis rate was observed in cytokine culture without feeder layer that showed significant difference with co-culture condition. The data showed that ex vivo expansion of CD34(+) cells in all three culture conditions after 10 days resulted in, significant increased expression of DAPK1, also a significant difference between co-culture without cytokine and two other cytokine culture was observed (p < 0.01). DAPK1gene promoter of expanded CD34(+) cells at days 5, 10 and 14 of culture remained in unmethylated form similar to fresh CD34(+) cells. Expression of DAPK1 in hematopoietic cells was increased during 10 days expansion of CD34(+) cells. Also no methylation of DAPK1 promoter was observed; otherwise it would be capable of initiating some leukemic cell progression or disruption in hematopoietic regeneration.

  9. Un Bain Culturel et Linguistique de Trois Mois en Milieu Francophone, Peut-Il effacer les Lacunes de l'Immersion (Can a Three-Month Interlinguistic Exchange in a Francophone Environment Overcome the Errors of Fossilization)?

    ERIC Educational Resources Information Center

    Lussier, Denise; Masse, Carole

    1995-01-01

    Reports on the speech difficulties of four French immersion anglophone students participating in a three-month interlinguistic exchange. Each student was interviewed three times, and the transcripts were analyzed for linguistic, sociolinguistic, and sociocultural errors in oral French and for performance evaluation by the students. (51 references)…

  10. Novel Perspectives in Redox Biology and Pathophysiology of Failing Myocytes: Modulation of the Intramyocardial Redox Milieu for Therapeutic Interventions-A Review Article from the Working Group of Cardiac Cell Biology, Italian Society of Cardiology.

    PubMed

    Arcaro, Alessia; Pirozzi, Flora; Angelini, Annalisa; Chimenti, Cristina; Crotti, Lia; Giordano, Carla; Mancardi, Daniele; Torella, Daniele; Tocchetti, Carlo G

    2016-01-01

    The prevalence of heart failure (HF) is still increasing worldwide, with enormous human, social, and economic costs, in spite of huge efforts in understanding pathogenetic mechanisms and in developing effective therapies that have transformed this syndrome into a chronic disease. Myocardial redox imbalance is a hallmark of this syndrome, since excessive reactive oxygen and nitrogen species can behave as signaling molecules in the pathogenesis of hypertrophy and heart failure, leading to dysregulation of cellular calcium handling, of the contractile machinery, of myocardial energetics and metabolism, and of extracellular matrix deposition. Recently, following new interesting advances in understanding myocardial ROS and RNS signaling pathways, new promising therapeutical approaches with antioxidant properties are being developed, keeping in mind that scavenging ROS and RNS tout court is detrimental as well, since these molecules also play a role in physiological myocardial homeostasis.

  11. The Maturing of a Profession: An Overview of Workplace Education Practitioner Development Opportunities = Une Profession en Plein Essor: Un apercu des possibilites de perfectionnement offertes aux practiciens de l'education en milieu de travail.

    ERIC Educational Resources Information Center

    Roger, Margarit

    This document consists of English and French versions of a report profiling some of the local, regional, and national professional development opportunities available to workplace education practitioners across Canada. The report begins with an introduction that describes the process used to identify the programs (surveys and interviews with more…

  12. Le mentorat dans le milieu de la santé: un hôpital de réadaptation lance un programme novateur pour les leaders émergents.

    PubMed

    Stuart, Michelle; Wilson, Carol

    2015-01-01

    Les médecins, la direction, le personnel et les bénévoles des entreprises veulent former de futurs leaders au sein de leur organisation. Le présent article décrit les efforts pour concevoir, mettre en œuvre et évaluer un programme de mentorat d'un an utilisé pour la première fois par le Glenrose Rehabilitation Hospital des Alberta Health Services. Des sondages d'évaluation ont été analysés pour faire ressortir les facteurs de succès décisifs, qui intégraient un vaste processus de candidatures diversifié de mentorés et de mentors, des critères bien définis de sélection ou de jumelage de mentorés et de mentors et un programme visant à soutenir l'acquisition du savoir par des projets, des séances d'apprentissage et des présentations.

  13. Prévalence et facteurs de risque du surpoids et de l'obésité dans une population d'enfants scolarisés en milieu urbain à Sfax, Tunisie

    PubMed Central

    Regaieg, Sofien; Charfi, Nadia; Trabelsi, Lobna; Kamoun, Mahdi; Feki, Habib; Yaich, Sourour; Abid, Mohamed

    2014-01-01

    Introduction L'objectif de ce travail etait d’étudier la prévalence du surpoids et de l'obésité chez un groupe d'enfants d’âge scolaire, habitant la ville de Sfax en Tunisie, et identifier les facteurs favorisant la prise pondérale Méthodes Il s'agossait d'une enquête descriptive transversale était réalisée en 2011 sur un échantillon représentatif d’élèves recrutés dans 11 écoles primaires publiques. Des informations concernant les caractéristiques sociodémographiques, les habitudes alimentaires et le comportement sédentaire pour chaque élève ont été précisées au moyen d'un questionnaire Résultats Nous avons colligé 1529 élèves, âgés entre 9 et 12 ans et se répartissant en 787 garçons (51,14%) et 747 filles (48,86%). Selon les seuils de référence de l'IOTF, la fréquence de l'obésité était de 2,4% et celle du surpoids était de 6,3%. L'obésité était significativement associée à l'obésité parentale, un niveau socioéconomique élevé, la prise de plus de deux goûters par jour et à l'activité sédentaire. Conclusion L'identification des facteurs de risque du surpoids et de l'obésité infantile permettrait de dépister les enfants à risques afin de leur proposer des mesures de prévention adaptées. Ces mesures de prévention devraient inclure non seulement des approches individuelles, mais aussi l'environnement social et physique de l'enfant. PMID:25018807

  14. Coumarine-imino-C2-glucosyl conjugate as receptor for Cu(2+) in blood serum milieu, on silica gel sheet and in Hep G2 cells and the characterization of the species of recognition.

    PubMed

    Areti, Sivaiah; Khedkar, Jayshree K; Bandaru, Sateesh; Teotia, Rohit; Bellare, Jayesh; Rao, Chebrolu Pulla

    2015-05-11

    A coumarine-imino-C2-glucosyl conjugate (L) was synthesized and characterized. The conjugate L is found to recognize Cu(2+) in aqueous HEPES buffer by exhibiting a 95% fluorescence quenching in pH range 7-10 even in the presence of several biologically and ecologically relevant metal ions. Fluorescence on-off behavior has been clearly demonstrated on the basis of the binding variability of Cu(2+) to L. The binding has been elicited through the changes observed in fluorescence, absorption, ESI-MS and (1)H NMR titrations. All the other thirteen metal ions studied did not show any change in the fluorescence emission. These ions do not interfere with the recognition of Cu(2+) by L. The structural features of [CuL]2 complex in both the isomeric forms were established by DFT computational calculations. The utility of L has been demonstrated by showing its sensitivity toward Cu(2+) on a thin layer of silica gel. The L gives sensitive fluorescence signals for Cu(2+) even in blood serum and exhibits appropriate fluorescence responses in living cells.

  15. Francais langue etrangere en milieu homoglotte et alloglotte: quels enseignements pour quelles pratiques effectives, quelles pratiques effectives apres quels enseignements? (French as a Foreign Language in Homoglot and Alloglot Environments: What Lessons To Teach for Which Effective Practices, Which Effective Practices Follow What Lessons?)

    ERIC Educational Resources Information Center

    Gauthier, Claude, Ed.; Jeanneret, Therese, Ed.

    2000-01-01

    The articles in this volume are based on a survey of language learners carried out at five Swiss universities. The surveys (done through interviews and questionnaires) concern the ways that students encounter their second language (French) outside the classroom, and which of those practices are the most effective in improving their French. The…

  16. Effet de la substitution du cuivre par du lithium sur les proprietes de l'oxyde spinelle lithium(x)cuivre(y-x)cobalt(3-y)oxygen(4) etudie pour l'electrocatalyse de la reaction de degagement de l'oxygene en milieu alcalin

    NASA Astrophysics Data System (ADS)

    Fatih, Khalid

    L'electrolyse de l'eau demeure la seule technologie industrielle de generation de l'hydrogene et de l'oxygene tres purs sans rejet de CO2 dans l'atmosphere, ce qui le rend tres attrayant par rapport a la combustion de carburants fossiles qui provoque presentement de serieux problemes environnementaux. Dans le but d'ameliorer le rendement de ce procede, nous avons developpe de nouveaux materiaux d'anode peu couteux, a base de l'oxyde mixte CuyCo3-yO 4, qui possedent une cinetique rapide pour la reaction de degagement de l'oxygene (RDO). Cette reaction suscite un interet particulier en raison de la surtension d'activation relativement elevee a l'anode qui cause la principale perte de rendement du procede. Une etude systematique a ete effectuee sur la substitution du Cu par du Li (0 a 40%), afin d'elucider les proprietes electrocatalytiques des oxydes LixCuy-xCo3-yO4. Ces oxydes, prepares sous forme de poudres par decomposition thermique des nitrates precurseurs entre 300 et 500°C, ont montre (DRX et FTIR) une structure spinelle inverse non-stcechiometrique avec une diminution du volume de la maille cristalline. La surface specifique par BET est d'environ 6 m2 g-1. Le pcn, obtenu par titrage acido-basique, a indique une diminution de la force du lien M-OH avec le taux du Li dans l'oxyde. Les analyses par XPS, realisees sur des films d'oxyde prepares par nebulisation reactive sur un substrat lisse de nickel, revelent un enrichissement de la surface en Cu a partir de 30% Li, et la presence des cations de surface Co2+, Co3+, Cu +, Cu2+ et Cu3+. La concentration de ce dernier montre un maximum a 10 et 20% Li. Suite a la substitution du Cu par du Li, la compensation de la charge serait assuree principalement par la formation d'especes Cu3+ pour les oxydes contenant jusqu'a 20% Li, et par la formation d'especes Co3+ aux taux de substitution superieurs. Les micrographies MEB montrent une morphologie hemispherique des particules d'oxyde reparties uniformement sur le substrat de nickel avec une tendance a l'agglomeration lorsque le taux de Li est accru. Les micrographies AFM revelent une micro-porosite de ces particules d'oxyde. Les films minces deposes sur un substrat de verre ont montre une conductivite tres interessante de l'ordre de 103O-1 cm-1 pour LixCuy-x Co3-yO4 comparee a 2,8 O-1 cm-1 pour Co3O4. La spectroscopie d'impedance a permis de distinguer les processus de la surface interne des films d'oxydes de ceux de l'interface electrode/electrolyte. Les courbes Mott-Schottky (1/C2 en fonction du potentiel) montrent que les films d'oxyde se comportent comme des semi-conducteurs de type p tres dopes (degeneres). Le potentiel de bandes plates et la densite des porteurs de charge majoritaires des oxydes LixCuy-xCo3-yO4 sont de l'ordre de 0,48 a 0,52 V et 1019 a 10 20 cm-3 respectivement. Pour Co 3O4 ces parametres sont de 0,47 V et ≈10 18 cm-3. (Abstract shortened by UMI.)

  17. Une méthode de calcul des coefficients de réflexion et de transmission d'une houle bidimensionnelle en milieu confinéA new method for the calculation of transmission and reflection coefficients for water waves in a small basin

    NASA Astrophysics Data System (ADS)

    Duclos, Gaëlle; Clément, Alain H.

    2003-03-01

    This paper presents a method to estimate reflected and transmitted wave amplitude spectra in a bounded domain such as a wave tank, when available data signals must be shortened due to interferences and wall effects. This paper extends the well known Goda and Suzuki two-probe method to three probes. The paper also suggests solutions to compute reliable transmission and reflection coefficients in spite of problems linked to higher harmonics and to the interference between different wave trains propagating in the tank. To cite this article: G. Duclos, A.H. Clément, C. R. Mecanique 331 (2003).

  18. Literacy and Health Project. Phase One. Making the World Healthier and Safer for People Who Can't Read = Projet alphabetisation et sante: Premiere etape. Rendre le milieu plus sain et sans danger pour les personnes qui ne savent pas lire.

    ERIC Educational Resources Information Center

    Ontario Public Health Association, Toronto.

    The Literacy and Health Project was set up to determine how reading and health problems were connected. A research phase documented the relationship between literacy and health. Information was collected from community organizations, literature review, three case studies in Ontario, and key informant interviews. The consultation process involved…

  19. Évaluation des propriétés énergétiques et microphysiques d'une source de convection artificielle à partir d' une étude de combustion organisée de fuel-oil en milieu naturel

    NASA Astrophysics Data System (ADS)

    Dinh, Pham Van; Benech, B.; Diamant, W.

    To evaluate the potential environmental impacts of waste heat released by future dry cooling towers, an oil burning system which emits sensible heat at a rate of the order of 1000 MW into the atmosphere has been built up at the Centre de Recherches Atmosphériques. The project involved development of an oil burner device and experiments to quantify the amounts of heat and other matters released from oil combustion, such as gas and aerosol, that are not present in the case of cooling towers but may interact with heat and cause complications. The burner produces a flame of 3-5 m in height and 0.5-1.5 m in diameter. Fuel is consumed at a rate of 3.5-16.5 ℓ min -1 at a pressure of 30-60 bars to develop a thermal output of 3-11 MW. The thermal power is distributed into three parts: sensible heat (82%), radiative energy (7-13%) and forced convection energy ( ~ 6 %); the two latter energy forms also heat the ambient air and so increase the real sensible heat output which eventually reaches 90 % of the thermal power. When the plume rises to some tens of meters, the combustion gas density is not very different from the air density and the additional water vapor does not exceed 5 % of the ambient water vapor. Smoke aerosol produced at the rate of 2-6gkg -1 of fuel-oil exhibits a maximum concentration of 10 7 particles cm -3 with a mean diameter of 0.5μm. The aerosol consists essentially of hydrophobic carbon (97%), while other elements, that may form hygroscopic or ice nuclei are present only in trace concentrations. The gaseous sulfur content may be higher but the SO 2 oxidation rate is very slow and then the cloud condensation nuclei amounts injected by the plume are neglegible in comparison with the natural nuclei. Thus the thermal impact on the atmosphere of the fuel oil combustion is essentially due to its thermodynamic characteristics, and our 105-burner system (Météotron) should correctly simulate in full scale a dry cooling tower. The smoke particles are quite useful as they make the plume visible and are used as passive tracers of the thermal disturbance.

  20. Workplace Learning: The Role of Canadian Colleges and Institutes in Meeting Canada's Professional, Technical and Trade Skills Challenges = L'apprentissage en milieu de travail: Le role des colleges et instituts canadiens face aux defis canadiens en matiere des competences professionnels et techniques.

    ERIC Educational Resources Information Center

    Malcolmson, Lorna, Ed.

    2002-01-01

    This issue examines selected topics in vocational education in Canadian community colleges. It focuses on the central themes of community college and industry partnerships, vocational education assessment, and vocational and workplace education pedagogical models. Articles include: (1) "Industry and Colleges: Key Partners in Meeting Canada's…

  1. Policy Conversation on Workplace/Workforce Literacy (Toronto, Ontario, Canada, January 22-24, 1995): A Report = Dialogue de Politique sur l'Alphabetisation en Milieu de Travail/de la Main-d'Oeuvre (Toronto, Ontario, Canada, 22-24 Janvier, 1995): Un Document de Synthese.

    ERIC Educational Resources Information Center

    National Literacy Secretariat, Ottawa (Ontario).

    This document is a compilation of a variety of documents that were prepared to summarize and document the Policy Conversation on Workplace and Work Force Literacy that was held in Canada to give concerned individuals an opportunity to share their hopes, concerns, dreams, and visions about key issues in workplace literacy. The following documents…

  2. Le role de l'identite ethnique dans l'acquisition et la retention de competences culturelles et de communication en milieu minoritaire francophone du Nord de l'Ontario (The Role of Ethnic Identity in Acquisition and Retention of Cultural and Communicative Competence in a Francophone Minority Context in Northern Ontario).

    ERIC Educational Resources Information Center

    Duquette, Georges

    A two-and-a-half-year study in northern Ontario (Canada) investigated the relationship between characteristics of the minority French-speaking community, home environment, and the school and classroom environments. Focus was on factors affecting the development and maintenance of cultural awareness, ethnic identity, and communicative competence in…

  3. Endometrial ablation in the management of abnormal uterine bleeding.

    PubMed

    Laberge, Philippe; Leyland, Nicholas; Murji, Ally; Fortin, Claude; Martyn, Paul; Vilos, George; Leyland, Nicholas; Wolfman, Wendy; Allaire, Catherine; Awadalla, Alaa; Dunn, Sheila; Heywood, Mark; Lemyre, Madeleine; Marcoux, Violaine; Potestio, Frank; Rittenberg, David; Singh, Sukhbir; Yeung, Grace

    2015-04-01

    Contexte : Les saignements utérins anormaux (SUA) sont directement à l’origine d’un fardeau de santé considérable que doivent porter les femmes, leur famille et la société en général. Jusqu’à 30 % des femmes chercheront à obtenir l’aide d’un médecin pour contrer ce problème au cours de leurs années de fertilité. Objectif : Fournir des lignes directrices factuelles à jour quant aux techniques et aux technologies utilisées aux fins de l’ablation de l’endomètre (AE), soit une intervention à effraction minimale permettant la prise en charge des SUA d’origine bénigne. Méthodes : Les membres du comité sur la directive clinique ont été sélectionnés en fonction de leurs spécialisations respectives en vue de représenter une gamme d’expériences pratiques et universitaires : le milieu de pratique au Canada, le type de pratique, la sous-spécialité et les antécédents généraux en gynécologie ont donc été pris en considération. Le comité a analysé les données pertinentes issues de la littérature médicale anglophone (y compris les lignes directrices publiées), en plus d’évaluer les issues chirurgicales et les issues qu’ont connues les patientes à la suite de l’utilisation de diverses techniques d’AE. Les recommandations ont été formulées par consensus. Données : La littérature publiée a été récupérée par l’intermédiaire de recherches menées dans MEDLINE et The Cochrane Library en 2013 et en 2014 au moyen d’un vocabulaire contrôlé et de mots clés appropriés (p. ex. « endometrial ablation », « hysteroscopy », « menorrhagia », « heavy menstrual bleeding », « AUB », « hysterectomy »). Les résultats ont été restreints aux analyses systématiques, aux études observationnelles et aux essais comparatifs randomisés / essais cliniques comparatifs publiés en anglais entre janvier 2000 et novembre 2014. Les recherches ont été mises à jour de façon r

  4. Kinderland in the Fatherland: Growing Children in Imperial Berlin

    ERIC Educational Resources Information Center

    Brian, Amanda

    2009-01-01

    This dissertation explores the milieu in which children of Imperial Berlin were raised. When contemporaries in the rapidly expanding capital of the Second German Empire (1871-1918) looked at children, this milieu darkened. The city, they argued, threatened children's growing bodies, and such institutions as the home, the clinic, and the school…

  5. Hyperglycemia and anthocyanin inhibit quercetin metabolism in HepG2 cells

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A high glucose (Glu) milieu promotes generation of reactive oxygen species, which may not only cause cellular damage, but also modulate phase II enzymes that are responsible for the metabolism of flavonoids. Thus, we examined the effect of a high Glu milieu on quercetin (Q) metabolism in HepG2 cells...

  6. Communication in Organizations. Technical Report No. 12.

    ERIC Educational Resources Information Center

    Porter, Lyman W.; Roberts, Karlene H.

    This review of research literature from 1963 to 1972 discusses implications of research for analysis of communication behavior in work organizations. The review is organized into four sections: contributions from organizational theory; research related to the interpersonal milieu; research related to the organizational milieu; and an examination…

  7. Beyond the Token Economy: A Comparison of Two Contingency Programs

    ERIC Educational Resources Information Center

    Greenberg, David J.; And Others

    1975-01-01

    To determine whether the addition of milieu principles to a contingency program increases its effectiveness, the investigators compared two treatment programs in a mental hospital: (a) a social learning or token economy approach and (b) a combined social learning and milieu approach. (Author)

  8. Reproductive switch and aging: the case of leptin change in dietary restriction.

    PubMed

    Koochmeshgi, Jalal

    2004-06-01

    We have proposed that normal food intake is geared toward optimizing the internal milieu for reproduction, despite some components of this milieu being detrimental to health. In dietary restriction, the animal is prevented from eating enough to attain or maintain reproductive capacity and this particular milieu does not materialize. Life extension occurs as a by-product. This idea provides a framework for exploring biomolecular changes in dietary restriction and their relevance to aging. Leptin is a case in point: here, a decrease in leptin level in dietary restriction is explored in the light of leptin's role in the complex signaling system of reproductive switch.

  9. Biomarkers of Lung Injury

    EPA Science Inventory

    Unlike the hepatic, cardiovascular, nervous, or excretory organ systems, where there .ls a strong contribution of host factors or extracellular biochemical milieu in causing organ damage, the causes of lung injuries and subsequent diseases are primarily from direct environmental ...

  10. From the litter up and the sky down: Perspectives on urban forest structure and eco-hydrological processes (presentation)

    EPA Science Inventory

    The structure of the urban forest represents the complex product of local biophysical conditions, socio-economic milieu, people preferences and management with rare counterparts in rural forests. However, urban forest structure, as similarly observed in rural forests, affects key...

  11. Impact of fetal programming, birth weight, and infant feeding on later hypertension.

    PubMed

    Ingelfinger, Julie R; Nuyt, Anne-Monique

    2012-06-01

    The concept of developmental origins of adult disease derives from both epidemiologic and basic sciences. This brief review considers the impact of the intrauterine milieu, intrauterine growth retardation, premature birth, and infant feeding on later hypertension and kidney disease.

  12. Impact of mycobacterial culture among HIV-infected adults with presumed TB in Uganda: a prospective cohort study.

    PubMed

    Semitala, F C; Chaisson, L H; den Boon, S; Walter, N; Cattamanchi, A; Awor, M; Katende, J; Huang, L; Joloba, M; Albert, H; Kamya, M R; Davis, J L

    2015-06-21

    Contexte : La mise en œuvre de nouvelles stratégies de diagnostic de la tuberculose (TB) dans les contextes de ressources limitées constitue un défi. Nous avons mesuré l'impact des cultures mycobactériennes en milieu solide et liquide sur les pratiques de traitement des patients ayant une évaluation de la TB à Kampala, Ouganda.Méthodes : Nous avons enrôlé des patients adultes consécutifs à frottis négatif, positifs pour le virus de l'immunodéficience humaine avec toux de ⩾2 semaines, de septembre 2009 à avril 2010. Les techniciens de laboratoire ont réalisé des cultures mycobactériennes en milieu solide et liquide. Nous avons comparé les décisions de traitement empirique aux cultures en milieu solide et liquide en termes de rendement diagnostique et de délai d'obtention des résultats et nous avons évalué l'impact sur la gestion des patients.Résultats : Des 200 patients enrôlés, 26 (13%) avaient une TB confirmée par culture, 22 (85%) par culture en milieu solide seule, 2 (8%) par culture en milieu liquide seul et 2 (8%) par culture à la fois en milieu solide et liquide. Trente-quatre patients ont reçu un traitement de TB empirique, mais seulement 10 (29%) ont eu une TB à culture positive. Le délai médian d'obtention d'un résultat de culture positive en milieu solide a été de 92 jours (IQR 69–148). Le délai médian d'obtention d'un résultat de culture positive en milieu liquide a été de 106 jours (IQR 66–157). Aucun patient n'a commencé un traitement à la suite d'un résultat de culture positive en milieu liquide.Conclusion : L'introduction de la culture mycobactérienne n'a pas influencé les soins aux patients bénéficiant d'une évaluation de TB à Kampala, Ouganda. Il est nécessaire d'être attentif aux facteurs contextuels entourant la mise en œuvre afin d'assurer une introduction effective de nouvelles stratégies de tests dans les pays à faible revenu.

  13. Les infections à Pseudomonas aeruginosa au service des maladies infectieuses du CHU YO, Burkina Faso: à propos deux cas

    PubMed Central

    Mamoudou, Savadogo; Lassina, Dao; Fla, Koueta

    2015-01-01

    Nous rapportons deux cas d'infection à Pseudomonas aeruginosa: un cas de méningite et un cas d'infection urinaire. Les auteurs rappellent qu’à côté des étiologies classiques des méningites et des infections urinaires, des germes résistants comme Pseudomonas aeruginosa peuvent être responsables d'infections à localisation méningées et urinaires et dont il faut connaître pour une bonne prise en charge. Le traitement de ces infections requiert un antibiogramme au regard de la grande capacité de résistance de Pseudomonas aeruginosa en milieu hospitalier. La limitation des gestes invasifs et l'application rigoureuse des mesures de prévention des infections en milieu hospitalier contribueront à lutter efficacement contre ces infections en milieu de soins. PMID:26491521

  14. Conservative Management of Cervical Ectopic Pregnancy.

    PubMed

    Murji, Ally; Garbedian, Kimberley; Thomas, Jacqueline; Cruickshank, Barbara

    2015-11-01

    Objectif : Évaluer l’innocuité et l’efficacité de la prise en charge conservatrice des grossesses ectopiques cervicales. Méthodes : Nous avons mené une analyse rétrospective de tous les cas de grossesse ectopique cervicale diagnostiqués au sein de notre centre universitaire tertiaire entre janvier 2002 et juillet 2014. Le diagnostic de grossesse ectopique cervicale a été établi par échographie transvaginale, conformément aux critères publiés. Les décisions quant à la prise en charge ont été prises par les cliniciens concernés. Résultats : Une grossesse ectopique cervicale a été diagnostiquée chez 27 femmes (âge médian : 34 ans). Les deux tiers d’entre elles étaient nullipares et 44 % (12/27) ont signalé une infertilité. L’âge gestationnel moyen au moment du diagnostic était de sept semaines. Le taux sérique médian de gonadotrophine chorionique humaine était de 11 300 UI/l (plage : de 610 à 163 700). Une activité cardiaque fœtale était présente dans 19 grossesses (70 %). Les saignements vaginaux constituaient la présentation la plus courante; de tels saignements étaient présents dans 23 cas (85 %). Trois femmes ont connu une hémorragie aiguë constituant un danger de mort. Tous les cas ont fait l’objet d’une prise en charge conservatrice réussie qui a permis la préservation de l’utérus. Le méthotrexate administré par voie générale (protocole à dose unique ou à doses multiples) constituait l’élément principal du traitement. Parmi les autres interventions à effraction minimale, on trouvait l’injection (orientée par échographie) de chlorure de potassium dans la grossesse, l’embolisation des artères utérines, la ligature vaginale des rameaux cervicaux des artères utérines et la dilatation-curetage (avec ou sans infiltration cervicale de vasopressine diluée et tamponnement par sonde de Foley). Conclusion : Le recours à du méthotrexate administré par voie générale, seul

  15. Development of pre-implantation porcine embryos cultured within a three-dimensional alginate hydrogel system either conjugated with Arg-Gly-Asp (RGD) peptide or supplemented with secreted phosphoprotein 1 (SPP1)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Many uterine specific factors have been shown to be increased within the uterine milieu as the porcine embryo initiates elongation. Secreted phosphoprotein 1 (SPP1) is increased during this time and contains an Arg-Gly-Asp (RGD) peptide sequence that has been shown to bind to cell surface integrins ...

  16. A Psychology of Teaching.

    ERIC Educational Resources Information Center

    Pedrini, D. T.; Pedrini, B. C.

    William James, the turn of the century psychologist, philospher, and educator, was avidly interested in the relationship between psychology and teaching. This paper considers operant conditioning, timing of reinforcers, and programmed instruction--touchstones of B.F. Skinner in the teaching/learning milieu. Of course, materials not just methods…

  17. Sustainability Science Education in Africa: Negotiating Indigenous Ways of Living with Nature in the Third Space

    ERIC Educational Resources Information Center

    Glasson, George E.; Mhango, Ndalapa; Phiri, Absalom; Lanier, Marilyn

    2010-01-01

    In response to global climate change, loss of biodiversity, and the immense human impact on the carrying capacity of the earth systems, attention has been given to sustainable development worldwide. In this paper, we explore the emerging field of sustainability science within the context of the socio-cultural milieu of Malawi, a sub-Saharan…

  18. Attaining Visual Literacy Using Simplified Graphics in Industry.

    ERIC Educational Resources Information Center

    Burton, Terry

    In the current milieu of ISO 9000 certification, just-in-time engineering (JIT), demand flow technology (DFT), and total quality management (TQM), industry is attempting to implement available technology for the creation, control, and delivery of documentation. In most cases, their efforts are in need of outside resources to analyze, develop,…

  19. Intellectual Biography in Higher Education: The Public Career of Earl J. McGrath as a Case Study.

    ERIC Educational Resources Information Center

    Reid, John Y.

    The method of writing an intellectual biography and the public career of Earl J. McGrath in the post-World War I cultural milieu are analyzed. One analytical framework is adapted from cultural anthropology and is used to describe the relationship of educational systems to other social systems and to culture as a whole. The second analytic frame,…

  20. Computers: from ethos and ethics to mythos and religion. Notes on the new frontier between computers and philosophy

    SciTech Connect

    Mitcham, C.

    1986-01-01

    This essay surveys recent studies concerning the social, cultural, ethical and religious dimensions of computers. The argument is that computers have certain cultural influences which call for ethical analysis. Further suggestions are that American culture is itself reflected in new ways in the high-technology computer milieu, and that ethical issues entail religious ones which are being largely ignored. 28 references.

  1. A Research Framework for Creative and Imitative Reasoning

    ERIC Educational Resources Information Center

    Lithner, Johan

    2008-01-01

    This conceptual research framework addresses the problem of rote learning by characterising key aspects of the dominating imitative reasoning and the lack of creative mathematical reasoning found in empirical data. By relating reasoning to thinking processes, student competencies, and the learning milieu it explains origins and consequences of…

  2. Exploring the Utility of Self-Modeling in Decreasing Disruptive Behavior in Students with Intellectual Disability

    ERIC Educational Resources Information Center

    Bilias-Lolis, Evelyn; Chafouleas, Sandra M.; Kehle, Thomas J.; Bray, Melissa A.

    2012-01-01

    Students with intellectual disabilities can exhibit a wide array of challenging behaviors in the classroom that pose disruptions to the learning milieu and management problems for those involved in their education. Self-modeling, a behavioral intervention that involves viewing edited videotapes of oneself depicting exemplary behavior, has had…

  3. Cultural Models in Communication with Infants: Lessons from Kikaikelaki, Cameroon and Muenster, Germany

    ERIC Educational Resources Information Center

    Demuth, Carolin; Keller, Heidi; Yovsi, Relindis D.

    2012-01-01

    Child rearing is a universal task, yet there are differing solutions according to the dynamics of socio-cultural milieu in which children are raised. Cultural models of what is considered good or bad parenting become explicit in everyday routine practices. Focusing on early mother-infant interactions in this article we examine the discursive…

  4. Monitoring the Future: National Survey Results on Drug Use, 1975-2005. Volume 1: Secondary School Students, 2005. NIH Publication No. 06-5883

    ERIC Educational Resources Information Center

    Johnston, Lloyd D.; O'Malley, Patrick M.; Bachman, Jerald G.; Schulenberg, John E.

    2006-01-01

    This monograph provides the 1975-2005 national trends in smoking, drinking, and illicit drug use among American secondary school students. It covers subgroup differences, attitudes and beliefs about use, social milieu, degree and duration of drug highs, initiation rates, prevalence and frequency, and trends in illicit drug and alcohol use. Drug…

  5. The Impact of Cultural Religious Values upon Pre-Service Teachers' Perceptions of Their Role as Educators in Catholic Religious Schools

    ERIC Educational Resources Information Center

    Gellel, Adrian-Mario; Buchanan, Michael T.

    2011-01-01

    The particular history, politics, social milieu and size of the islands of Malta contributed to the formation of specific cultural values and identity. Central to this identity is a unique language and a very strong Catholic community. These factors remain integral (but not exclusive) aspects of the Maltese national identity. This identity has…

  6. Sailing through Stormy Seas: An Israeli Kindergarten Teacher Confronts Holocaust Remembrance Day

    ERIC Educational Resources Information Center

    Brody, David

    2009-01-01

    The young child's exposure to disaster and trauma through the media or in the social milieu poses a challenge for the early childhood educator who is faced with responding and educating in a developmentally appropriate manner. In the case of public commemoration of a national disaster, the classroom implications are seemingly unavoidable. This…

  7. Seeking Resilience and Sustainability: Outdoor Education in Singapore

    ERIC Educational Resources Information Center

    Martin, Peter; Ho, Susanna

    2009-01-01

    Outdoor education is not a universal value. Rather, outdoor education's contributions need to be grounded in time, place and culture. In this paper we describe the historical and cultural milieu that has enabled the emergence of outdoor education in Singapore and report on exploratory survey research into Singaporean teachers' conceptions of…

  8. A Review of the Roles of Pet Animals in Psychotherapy and With the Elderly.

    ERIC Educational Resources Information Center

    Brickel, Clark M.

    1980-01-01

    A survey of case histories, anecdotal evidence and pilot studies shows that, as therapeutic adjuncts, pet animals facilitate rapport and enrich the treatment milieu. Pets enhance the lives of their owners in the community. Pet-facilitated psychotherapy can increase social interaction, provide comfort, and reinforce feelings of independence.…

  9. Laptopers in an Educational Practice: Promoting the Personal Learning Situation

    ERIC Educational Resources Information Center

    Lindroth, Tomas; Bergquist, Magnus

    2010-01-01

    In this article an ethnographical study of laptopers' activities during lectures in a university milieu is analyzed as different kinds of involvements. Through interviews and observations we have focused on how these involvements influence the laptopers' alignment towards the educational practice. The analysis shows the importance of separating…

  10. Practical Curriculum Inquiry: Students' Voices of Their EFL Curriculum and Instruction

    ERIC Educational Resources Information Center

    Hongboontri, Chantarath

    2014-01-01

    This mixed-methods study borrowed Schwabian notions of practical curriculum inquiry (1969, 1971, 1973, 1983) to investigate students' perceptions of their English as a foreign language (EFL) curriculum and instruction in light of their interactions with the four commonplaces; i.e., teachers, learners, subject matter, and milieu. Data were gathered…

  11. Traditional Educational Philosophy: Relevance to Baccalaureate Curriculum Development.

    ERIC Educational Resources Information Center

    Peebles, Wilma C.; Suval, Elizabeth M.

    1983-01-01

    The instructional relevance of four educational philosophies--idealism, realism, experimentalism, and existentialism--to the undergraduate social work curriculum design and educational milieu is explored. The relationship of the problem-solving focus of experimentalism to social work intervention is discussed. (MSE)

  12. Micro-Social Factors in the Development of Entrepreneurial Giftedness: The Case of Richard Branson

    ERIC Educational Resources Information Center

    Shavinina, Larisa V.

    2006-01-01

    Research shows that social circumstances influence the development of an individual's high abilities. This paper identifies the micro-social1 factors in the development of entrepreneurial giftedness. Specifically, the paper considers the family milieu, 'significant others' and great contemporaries in the case of Richard Branson, the most…

  13. Practice Parameter for Psychiatric Consultation to Schools

    ERIC Educational Resources Information Center

    Journal of the American Academy of Child and Adolescent Psychiatry, 2005

    2005-01-01

    This practice parameter reviews the topic of psychiatric consultation to schools. The review covers the history of school consultation and current consultative models; the process of developing a consultative relationship; school administrative procedures, personnel, and milieu; legal protections for students with mental disabilities; and issues…

  14. The Augustinian Values Institute: Preserving a Legacy of Augustinian Education

    ERIC Educational Resources Information Center

    Baker, Stephen J.

    2016-01-01

    A concern for Catholic educators is how to keep Catholic schools viable and healthy in a milieu of diminishing numbers of religious as well as a very complex and changing world. This article addresses the Augustinians' response to the challenge to keep the Order's mission of education alive and thriving in the 21st century. This article hopes to…

  15. How Students Experience and Navigate Transitions in Undergraduate Medical Education: An Application of Bourdieu's Theoretical Model

    ERIC Educational Resources Information Center

    Balmer, Dorene F.; Richards, Boyd F.; Varpio, Lara

    2015-01-01

    Using Bourdieu's theoretical model as a lens for analysis, we sought to understand how students experience the undergraduate medical education (UME) milieu, focusing on how they navigate transitions from the preclinical phase, to the major clinical year (MCY), and to the preparation for residency phase. Twenty-two medical students participated in…

  16. A Transactional Model of Spoken Vocabulary Variation in Toddlers with Intellectual Disabilities

    ERIC Educational Resources Information Center

    Woynaroski, Tiffany; Yoder, Paul J.; Fey, Marc E.; Warren, Steven F.

    2014-01-01

    Purpose: The authors examined (a) whether dose frequency of milieu communication teaching (MCT) affects children's canonical syllabic communication and (b) whether the relation between early canonical syllabic communication and later spoken vocabulary is mediated by parental linguistic mapping in children with intellectual disabilities (ID).…

  17. Knowledge Production through Interdisciplinary Skills: Producing an Effective Postgraduate Research Curriculum

    ERIC Educational Resources Information Center

    Chitakunye, Pepukayi; Takhar-Lail, Amandeep

    2015-01-01

    This study contributes to existing methodological knowledge by showing how a transformed research methods curriculum, which is beyond the milieu of schooling, can engage postgraduate students in a critical dialogue on how knowledge is produced in industry and higher education. Initial insights are drawn from two interpretive studies that employed…

  18. Mobile Applications and Decolonization: Cautionary Notes about the Curriculum of Code

    ERIC Educational Resources Information Center

    Smith, Bryan

    2016-01-01

    The current generation of students live and learn within a pedagogical milieu saturated by digital technologies. Curriculum scholars have not ignored this, theorizing and critiquing the ways that technology both affords and limits opportunities for students. Notably absent from this conversation, however, is a consideration of how the technologies…

  19. School Readiness of Children with Language Impairment: Predicting Literacy Skills from Pre-Literacy and Social-Behavioural Dimensions

    ERIC Educational Resources Information Center

    Pentimonti, Jill M.; Murphy, Kimberly A.; Justice, Laura M.; Logan, Jessica A. R.; Kaderavek, Joan N.

    2016-01-01

    Background: School readiness generally captures the notion that children do best when they arrive at formal schooling with a certain threshold of skill that will help them thrive in the classroom's academic and social milieu. Aims: To examine the dimensionality of the construct of school readiness among children with language impairment (LI), as…

  20. Teachers' Professional Development for ICT Integration: Towards a Reciprocal Relationship between Research and Practice

    ERIC Educational Resources Information Center

    Albion, Peter R.; Tondeur, Jo; Forkosh-Baruch, Alona; Peeraer, Jef

    2015-01-01

    Teachers in the 21st century are facing new challenges as a result of the expanding possibilities of ICT integration in every aspect of the school milieu. Studies have shown the potential of teacher professional development (TPD) that is tailored to local conditions as well as global components and takes advantage of mutual support among teachers,…

  1. Invitation to a Postmodern Reflection on Critical Social Cartography.

    ERIC Educational Resources Information Center

    Paulston, Rolland G.; Liebman, Martin

    This document demonstrates how social cartography can be used in social research to include individuals and cultural clusters who want their own narratives included in the social discourse. Social cartography is defined as the creation of maps addressing questions of location in the social milieu. Visual images, depicting on the two dimensional…

  2. An Invitation to Postmodern Social Cartography.

    ERIC Educational Resources Information Center

    Paulston, Rolland G.; Liebman, Martin

    1994-01-01

    Structures of multiple education and knowledge systems can be recreated in maps, in a social cartography where the space of the social map reflects effects of social changes in real space. Such maps allow social research to escape from modernism's positivist restraints, improve comparative educators' understanding of the social milieu, and open…

  3. An Invitation to Postmodern Social Cartography.

    ERIC Educational Resources Information Center

    Paulston, Rolland G.; Liebman, Martin

    This essay demonstrates how social cartography--the writing and reading of maps addressing questions of location in the social milieu--may enhance social research and move it forward in its struggles to distance itself from the positivistic restraints of modernism. Social cartography suggests an opening of dialogue among diverse social players,…

  4. The KIDTALK Behavior and Language Code: Manual and Coding Protocol.

    ERIC Educational Resources Information Center

    Delaney, Elizabeth M.; Ezell, Sara S.; Solomon, Ned A.; Hancock, Terry B.; Kaiser, Ann P.

    Developed as part of the Milieu Language Teaching Project at the John F. Kennedy Center at Vanderbilt University in Nashville, Tennessee, this KIDTALK Behavior-Language Coding Protocol and manual measures behavior occurring during adult-child interactions. The manual is divided into 5 distinct sections: (1) the adult behavior codes describe…

  5. Teaching and Learning Competent Historical Documentary Making: Lessons from National History Day Winners

    ERIC Educational Resources Information Center

    Fehn, Bruce R.; Schul, James E.

    2011-01-01

    Today's students grow up in a technological milieu of hand-held computers with high storage capacities, internet access, and the ability to shoot high definition photographs and video. As such, they are empowered to construct representations of the past virtually "on the run." In this article, the authors investigated the historical "and"…

  6. L'interdisciplinarite en sciences sociales pour l'etude du contact des langues (Interdisciplinarity in Social Sciences of the Study of the Relationships of Languages). Proceedings of a Colloquium of the International Center for Research on Bilingualism and the Institute for Interethnic and Intercultural Studies and Research (2nd, Quebec City, Quebec, Canada, October 1-5, 1984).

    ERIC Educational Resources Information Center

    Prujiner, Alain, Ed.

    Papers given at an international conference applying the social sciences to the study of the relationships of languages include the following: "Reseaux sociaux et comportements langagiers en milieu de contact des langues" ("Social Networks and Language Behaviors in a Language Contact Setting") by M. Blanc and J. Hamers, with…

  7. Transcultural Cooperation: The Years Ahead

    ERIC Educational Resources Information Center

    Braisted, Paul J.

    1975-01-01

    "The future will bring new opportunities for transcultural cooperation through privately sponsored exchange activities." This analysis of future opportunities includes review of the heritage of educational and cultural exchange and the emerging cultural milieu of political and economic instability, examples of new activities, and characteristics…

  8. Internal-External Locus of Control in Middle and Later Life: The Search for Construct Validation.

    ERIC Educational Resources Information Center

    Bielby, Denise D.; Siegler, Ilene C.

    This study validates the developmental nature of internal-external locus of control in middle and old age. Longitudinal stability of locus of control in the face of particular changes in social milieu common during the transition from middle to late life was contrasted with that of verbal intelligence, a known stable characteristic, and that of…

  9. The Purposes Outdoor Education Does, Could and Should Serve in Singapore

    ERIC Educational Resources Information Center

    Ho, Susanna

    2014-01-01

    This paper discusses the purposes that outdoor education does, could and should serve in Singapore. Gert Biesta's conceptualisation of three functions of education is adapted to frame deliberations on the purposes of outdoor education in Singapore's socio-political and educational milieu. The author suggests that outdoor education in Singapore…

  10. Racism and Education: Different Perspectives and Experiences = Le racisme et l'education: Perspectives et experiences diverses.

    ERIC Educational Resources Information Center

    Canadian Teachers' Federation, Ottawa (Ontario).

    These 12 essays provide insights into how racism demoralizes and debilitates the confidence of all Canadians affected in the educational milieu, especially the young. The writers all unmistakably signal the challenge for change and a renewed commitment to justice and equality. Essays include: (1) "There is a Better Canadian Answer"…

  11. Enhancing Reflective Practice in Multicultural Counseling through Cultural Auditing

    ERIC Educational Resources Information Center

    Collins, Sandra; Arthur, Nancy; Wong-Wylie, Gina

    2010-01-01

    Counselors work in an increasingly complex cultural milieu where every encounter with a client must be considered multicultural in nature. Reflective practice is a central component of professional competence and necessarily involves attention to culture. The cultural auditing model provides an effective and flexible reflective process for…

  12. Language Policy in Canada: Current Issues. A Selection of the Proceedings of the Papers Dealing with Language Policy Issues in Canada at the Conference "Language Policy and Social Problems" (Curacao, Venezuela, December, 1983). Publication B-150.

    ERIC Educational Resources Information Center

    Cobarrubias, Juan, Ed.

    The papers related to Canadian language policy at an international conference are presented: "Language Policy in Canada: Current Issues" (Juan Cobarrubias); "Multiculturalism and Language Policy in Canada" (Jim Cummins, Harold Troper); "Defining Language Policy in a Nationalistic Milieu and in a Complex Industrialized…

  13. Heidegger, Digital Technology, and Postmodern Education: From Being in Cyberspace to Meeting on MySpace

    ERIC Educational Resources Information Center

    Walters, Patrick; Kop, Rita

    2009-01-01

    Digital technology is transforming life and is beginning to have a profound effect on individual psychic life and the wider social milieu. This article seeks to understand the nature of the new technology and its implications for personal life, culture, and education. The scene is set by comparing the introduction of printing to the revolution…

  14. A Physiologist's View of Homeostasis

    ERIC Educational Resources Information Center

    Modell, Harold; Cliff, William; Michael, Joel; McFarland, Jenny; Wenderoth, Mary Pat; Wright, Ann

    2015-01-01

    Homeostasis is a core concept necessary for understanding the many regulatory mechanisms in physiology. Claude Bernard originally proposed the concept of the constancy of the "milieu interieur," but his discussion was rather abstract. Walter Cannon introduced the term "homeostasis" and expanded Bernard's notion of…

  15. Organization Model of a Constructivist Learning Community: A Teilhardian Metaphor for Educators.

    ERIC Educational Resources Information Center

    White, Stephen R.

    2002-01-01

    Argues for learning communities as a fruitful milieu for cognitive development and knowledge construction. Provides a metaphor of a constructivist learning community organization grounded on French scientist and philosopher Pierre Teilhard de Chardin's theory of evolution. Asserts that Teilhardian thought is useful for conceptualizing a…

  16. Space-Centred English Language Learning: The Cyprus Case

    ERIC Educational Resources Information Center

    Kurt, Mustafa; Kurt, Sevinc

    2013-01-01

    This paper discusses a study conducted in the Ledra/Lokmaci Milieu in Cyprus, the area in the centre of the divided walled city of Nicosia where Greek and Turkish Cypriots have to use English to communicate with one another. The aim of the study was to locate the effects of a learning space on language learners, teachers and syllabus designers.…

  17. Discourse Strategies in Francophone African Literary Works.

    ERIC Educational Resources Information Center

    Kapanga, Andre Mwamba

    1992-01-01

    The cross-cultural use of French in francophone Africa has resulted in creative linguistic and stylistic modifications reflecting the sensibilities, inherited cultural patterns, and disposition of its users. French is acquired in the sociocultural context of Africa and not the Christian, Franco-European intellectual milieu. Readers of literary…

  18. Filtering Shakespeare Teaching through Curricular Commonplaces

    ERIC Educational Resources Information Center

    Rice, Mary

    2012-01-01

    Schwab (1978) argued that curriculum emerged in the commonplaces of teacher, learner, subject matter and milieu. It was in these four frames that I narratively explored my own development as an English teacher and curriculum planner around Shakespeare's work, particularly "The Tragedy of Romeo and Juliet." In this narrative, I relate four…

  19. Growing People: A Model That Works. Welcome to Success. The School Program Narrative of the Yellowstone Boys and Girls Ranch School.

    ERIC Educational Resources Information Center

    Yellowstone Boys and Girls Ranch School, Billings, MT.

    The booklet describes the philosophy and operation of the Yellowstone Boys and Girls Ranch School Program, an integrated public school residential treatment mainstream educational model located within an accredited residential psychiatric facility in Montana. The therapeutic milieu is designed to redirect children's self-perception. Descriptive…

  20. Higher Education Teachers' Experiences with Learning Analytics in Relation to Student Retention

    ERIC Educational Resources Information Center

    West, Deborah; Huijser, Henk; Heath, David; Lizzio, Alf; Toohey, Danny; Miles, Carol; Searle, Bill; Bronnimann, Jurg

    2016-01-01

    This paper presents findings from a study of Australian and New Zealand academics (n = 276) that teach tertiary education students. The study aimed to explore participants' early experiences of learning analytics in a higher education milieu in which data analytics is gaining increasing prominence. Broadly speaking participants were asked about:…

  1. The Effects and Feasibility of Using Tiered Instruction to Increase Conversational Turn Taking for Preschoolers with and without Disabilities

    ERIC Educational Resources Information Center

    Robbins, Sandra Hess

    2013-01-01

    The purpose of the study was to examine the effectiveness and feasibility of using tiered instruction to increase the frequency of conversational turn taking (CTT) among preschoolers with and without disabilities in an inclusive setting. Three CTT interventions (Universal Design for Learning, Peer Mediated Instruction, and Milieu Teaching) were…

  2. Cultural Differences: Whose Troubles Are We Talking About?

    ERIC Educational Resources Information Center

    Kahne, Merton J.

    1976-01-01

    Arguing that foreign students must be understood in terms of the actual academic and social milieu of the particular college or community rather than on sweeping psychological or social generalizations, the author suggests colleges aid them in tailor-making their own programs of orientation and continued support. (JT)

  3. Characterization and mucosal responses of interleukin 17 family ligand and receptor genes in channel catfish Ictalurus punctatus

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Interleukin (IL) 17 family cytokines are important mediators of mucosal immune responses, tightly regulated by signals from the complex milieu of pathogenic and commensal microbes, epithelial cells and innate and adaptive leukocytes found at tissue barriers. In mammals, IL17 ligand expression has be...

  4. A Systems Approach for Ameliorating Possible Prima Facie Denial of Hispanic/Black Students' Rights Through Disproportionate Enrollment in Special Education.

    ERIC Educational Resources Information Center

    McDonnell, James R.

    The paper discusses the issue of educational equity, principles of systems analysis, systems approaches in the educational milieu, the evaluation aspect of the systems approach, and application of the systems approach to preventing disproportionate enrollment of Hispanics and Blacks in special education classes in Holyoke, Massachusetts. The…

  5. India: Financing of Elementary Education in India in the 1990s. South Asia Education Sector Technical Working Paper.

    ERIC Educational Resources Information Center

    Sipahimalani, Vandana

    This paper studies the trends in the financing of elementary education in India over the past decade. In 1994 the Indian Supreme Court issued a directive to universalize free and compulsory elementary education, but that in a changing economic milieu where social service expenditures have often been reduced in other countries, it is important to…

  6. Worlds Apart: Why Poverty Persists in Rural America.

    ERIC Educational Resources Information Center

    Duncan, Cynthia M.

    This book examines the nature of persistent poverty in two impoverished towns in the coalfields of Appalachia and the Mississippi Delta and a contrasting social milieu in a prosperous but remote rural mill town in northern New England. Drawing on 350 in-depth interviews and census data, the book analyzes the dynamics of poverty, politics, and…

  7. OZONE DEPLETION AND THE AIR-SEA EXCHANGE OF GREENHOUSE AND CHEMICALLY REACTIVE TRACE GASES

    EPA Science Inventory

    One of the most important aspects of global change is that of stratospheric ozone depletion and the resulting increase in UV radiation reaching the surface of the Earth. Some 70% of the Earth surface is covered by water containing an extremely complicated milieu of organic and in...

  8. Passport to the Front of the Bus: The Impact of Fisk University's International Program on Segregation in Nashville, Tennessee.

    ERIC Educational Resources Information Center

    Gasman, Marybeth

    In the 1950's, Charles S. Johnson, the first black president of Fisk University (Tennessee), greatly expanded the institution's international program, attracting many foreign students to the school and creating a milieu that gave American blacks the benefits of integration. This paper examines how the presence of outsiders and outside influences…

  9. The Differential Effect of Three Naturalistic Language Interventions on Language Use in Children with Autism

    ERIC Educational Resources Information Center

    Ingersoll, Brooke

    2011-01-01

    Naturalistic interventions show promise for improving language in children with autism. Specific interventions differ in direct elicitation of child language and indirect language stimulation, and thus may produce different language outcomes. This study compared the effects of responsive interaction, milieu teaching, and a combined intervention on…

  10. Traditional & Socio-Cultural Barriers to EFL Learning: A Case Study

    ERIC Educational Resources Information Center

    Ahmad, Jameel

    2015-01-01

    This research tends to ascertain several traditional and socio-cultural barriers to English language learning in Saudi Arabia and to explore more ways than before for making teaching and learning more effective. The findings of four quantitative and qualitative surveys conducted in this regard reveal a unique traditional and socio-cultural milieu,…

  11. Research Problems in Curriculum: Alternative Paradigms.

    ERIC Educational Resources Information Center

    Connelly, F. Michael

    Curriculum research appropriately follows, rather than precedes, development. According to the "breakthrough" view of research, curriculum development and curriculum practice exhibit a deductive applied relationship to curriculum research. The obvious fault in this view is that it ignores the milieu of value claims about what is ideal and what is…

  12. Seeking Restorative Experiences: Elementary School Teachers' Choices for Places that Enable Coping with Stress

    ERIC Educational Resources Information Center

    Gulwadi, Gowri Betrabet

    2006-01-01

    Teacher stress and coping research and restorative environments research were converged in this study to explore how elementary school teachers in Chicago seek out everyday places in their milieu to implement restorative coping strategies. Seventy-one survey responses revealed that teachers' spontaneous place choices are related to sources of…

  13. Strategies for Staff Development: Personal and Professional Education in the 21st Century.

    ERIC Educational Resources Information Center

    Schwartz, Robert A., Ed.; Bryan, William A., Ed.

    1998-01-01

    Central to the delivery of quality learning opportunities and services for students in the next century is an educated, energetic, motivated management and support staff in tune with their campus milieu and committed to their institution's mission. This volume explores the nature of staff development and emphasizes the fact that staff development…

  14. L'acquisition d'une language seconde: Quelques developpements theoriques recents (Second Language Acquisition: Some Recent Theoretical Developments).

    ERIC Educational Resources Information Center

    Py, Bernard, Ed.

    1994-01-01

    This collection of articles on second language learning includes: "Action, langage et discours. Les fondements d'une psychologie du langage" ("Action, Language, and Discourse. Foundations of a Psychology of Language") (Jean-Paul Bronckart); "Contextes socio-culturels et appropriation des languages secondes: l'apprentissage en milieu social et la…

  15. Re(con)ceiving Young Children's Curricular Performativity

    ERIC Educational Resources Information Center

    Sellers, Marg

    2010-01-01

    Working (with) Deleuzo-Guattarian philosophical imaginaries opens (to) a multiplicity of possibilities for thinking differently about curriculum, young children and how they perform their curricular understandings. In this article I work (as) rhizome, bringing the imaginaries "becoming" and "milieu" into an early childhood curriculum conversation…

  16. Industry Perceptions of Industry-University Partnerships Related to Doctoral Education in South Africa

    ERIC Educational Resources Information Center

    Herman, Chaya

    2013-01-01

    An assessment of the extent to which industry-university partnerships in doctoral education, which have become increasingly prevalent in the knowledge economy, have begun to penetrate the South African higher education milieu, is reported. The factors that motivate large industries in developing countries such as South Africa to invest in doctoral…

  17. The Multilingual Classroom: New Rhetorical Frontiers in L2 Writing?

    ERIC Educational Resources Information Center

    Magistro, Elena

    2007-01-01

    This paper presents some considerations on teaching L2 rhetorical conventions in university-level multilingual classrooms. It is claimed that if L2 students need to acquire versatile writing skills in L2 to be given a voice in the discourse milieu of the receiving society, they should also have the right to preserve their L1 cultural perspective.…

  18. The Bricoleur, the Engineer and the Kaitiaki: Reconceptualising the Work of VET Educators

    ERIC Educational Resources Information Center

    Maurice-Takerei, Lisa

    2016-01-01

    The paper presents a reconceptualisation of trades tutors drawn from tutors themselves. Trade educators here are seen as multidisciplinary, multi-dimensional practitioners with an occupational milieu that goes beyond the reductionist and instrumentalist views of teaching with which vocational education is often beset. Trade-tutor perspectives on…

  19. Geographic Considerations in International Studies.

    ERIC Educational Resources Information Center

    Kott, Richard F.

    Based on students' generally shallow knowledge of geographic concepts on the one hand and a new and almost universal awareness of man in his milieu on the other, the author seeks to draw attention to the discipline of geography, and more specifically, political geography as an essential, fundamental component of international studies. The…

  20. Achievement Goals, the Classroom Environment, and Reflective Thinking: A Conceptual Framework

    ERIC Educational Resources Information Center

    Phan, Huy P.

    2008-01-01

    Introduction: Research pertaining to achievement goals and reflective thinking practice has received considerable attention in educational psychology. However, very few, if any, studies have looked at the impact of the classroom climate and how this psychosocial milieu may influence students' engagement in achievement goals and reflective thinking…

  1. How Higher Education Institutions Contribute to the Growth in Regions of Europe?

    ERIC Educational Resources Information Center

    Lilles, Alo; Rõigas, Kärt

    2017-01-01

    Various studies show that higher education institutions contribute to regional economic development by R&D, creation of human capital, knowledge and technology transfer, and by creation of a favourable milieu. It is brought out that the basic procedure is to sum expenditures of the college community (students, faculty, staff and visitors)…

  2. Understanding "The Great Gatsby" Online: A Student Casebook to Issues, Sources, and Historical Documents.

    ERIC Educational Resources Information Center

    Gross, Dalton; Gross, MaryJean

    Today, more than 70 years after its publication, the novel "The Great Gatsby" seems as fresh and pertinent to American life as it did in the 1920s. The social, cultural, and historical milieu of the 1920s reflected in its pages is not so very different from that of today. This interdisciplinary collection of commentary and collateral…

  3. Empowering Grandparents Raising Grandchildren: A Training Manual for Group Leaders. Springer Series on Life Styles and Issues in Aging.

    ERIC Educational Resources Information Center

    Cox, Carole B.

    Noting that grandparents in the parenting role are often overwhelmed by the problems of their children, grandchildren, and the social milieu in which they live, this manual presents a 14-session workshop series designed to empower grandparents who are raising their grandchildren alone. Designed to complement "To Grandmother's House We Go and…

  4. The Authority of Truth: Religion and the John Peter Zenger Case.

    ERIC Educational Resources Information Center

    Nord, David Paul

    An appreciation of the religious milieu of the John Peter Zenger libel case of 1735 can help explain the nature of the Zenger defense as prepared by Alexander Hamilton, the meaning of the jury's verdict, and the ambiguous legacy of the trial for freedom of expression in the United States. In essence, the case was a disputation on "truth"…

  5. Reforming U.S. Education for the Academic Study of Religion

    ERIC Educational Resources Information Center

    Waggoner, Michael D.

    2011-01-01

    Religion and spirituality are gaining renewed appreciation as key elements of the cultural milieu. Yet there has been an inattention to the academic study of religion and spirituality in U.S. education due to several contributing causes. Central to remediating this deficiency is an understanding of these causes and how the reform of key factors in…

  6. What the West Could Learn from the East: A Reflective Analysis

    ERIC Educational Resources Information Center

    Zou, Yali; Craig, Cheryl J.; Poimbeauf, Rita P.

    2016-01-01

    Drawing on Lugones' ideas of world traveling, Dewey's notion of education as experience, and Greene's vision of seeing small/seeing big, this article inquires into lives lived in an Eastern educational milieu with attention reflectively paid to what educators in the West could learn from those in the East. Rather than focusing on mega narratives…

  7. Evangelizing Eugenics: A Brief Historiography of Popular and Formal American Eugenics Education (1908-1948)

    ERIC Educational Resources Information Center

    Kohlman, Michael J.

    2012-01-01

    This article examines the history of the American Eugenics movement's penetration into the formal and popular educational milieu during the first half of the 20th Century, and includes a review of some recent scholarly research on eugenic themes in education and popular culture. Apologists have dismissed the American Eugenics movement as a…

  8. "Outstanding Individuals Do Not Arise from Ancestrally Poor Stock": Racial Science and the Education of Black South Africans.

    ERIC Educational Resources Information Center

    Appel, Stephen W.

    1989-01-01

    Examines the construction of racial scientific discourse within the milieu of an extremely racially segregated society. Traces the influence of capitalism, racism, Social Darwinism, eugenics, and "racial science" on the pedagogy of modern apartheid in South Africa. Finds evidence of pervasive effects of "scientific" ideas on…

  9. The Effects of Family Occupation Type, Sex, and Appeal Style on Helping Behavior

    ERIC Educational Resources Information Center

    Fink, Edward L.; And Others

    1975-01-01

    A campus blood donation drive provided an opportunity to examine the variables of family occupational type as a milieu for the socialization of altruism, appeal style stressing equity or dependency, and sex-role attitude (traditional and nontraditional) in influencing helping behavior. (Editor)

  10. Fostering a Pluralistic Society through Multi-Ethnic Education. Fastback 107.

    ERIC Educational Resources Information Center

    Garcia, Ricardo L.

    The purpose of multiethnic education is to prepare all students to live harmoniously in a multiethnic society. Multiethnic education pursues these goals by reflecting ethnic diversity in the curriculum, dealing directly with ethnic group similarities and differences, and helping students understand their uniqueness in a pluralistic milieu.…

  11. Tracing Family, Teaching Race: Critical Race Pedagogy in the Millennial Sociology Classroom

    ERIC Educational Resources Information Center

    Mueller, Jennifer C.

    2013-01-01

    The "millennial" historical moment presents fresh dilemmas for race-critical instructors. In addition to being well-versed in colorblind racial discourse, millennial students are socialized in a pop-cultural milieu that implies a more integrated, racially egalitarian world than exists in reality and includes claims that U.S. society is now…

  12. Preparing Globally Competent Teacher Candidates through Cross-Cultural Experiential Learning

    ERIC Educational Resources Information Center

    Kopish, Michael A.

    2016-01-01

    This manuscript presents findings and implications from a case study of one global educator's attempt to develop globally competent teacher candidates in an elective teacher preparation course. Global Citizenship Education served as the framing paradigm for the course and human experiences of immigrants and refugees served as the milieu for…

  13. "The Last of the Mohicans" Reconsidered.

    ERIC Educational Resources Information Center

    Merchant, Peter

    1993-01-01

    Identifies in the novel, "The Last of the Mohicans," some of the artistic strategies by which James Fenimore Cooper converted the tale into the novel. Considers why the novel continues to provoke cultural interest in today's milieu. Overviews the historical reception of the work. (HB)

  14. Exploring Differences between Self-Regulated Learning Strategies of High and Low Achievers in Open Distance Learning

    ERIC Educational Resources Information Center

    Geduld, Bernadette

    2016-01-01

    Open distance students differ in their preparedness for higher education studies. Students who are less self-regulated risk failure and drop out in the challenging milieu of open distance learning. In this study, the differences between the application of self-regulated learning strategies by low and high achievers were explored. A multi-method…

  15. Augmenting Caregiver Responsiveness: An Intervention Proposal for Youngsters with Autism in Brazil

    ERIC Educational Resources Information Center

    Nunes, Débora R. P.; Araújo, Eliana R.; Walter, Elizabeth; Soares, Rute; Mendonça, Camila

    2016-01-01

    Language disorders that affect children with autism spectrum disorder can bring significant damage to their overall development. Research shows that the best treatment practices for this population are those that start early, have active parental collaboration and are held in natural milieu. In Brazil, early intervention programs are typically…

  16. Emily Dickinson Was a Poetess

    ERIC Educational Resources Information Center

    Greene, Elsa

    1972-01-01

    Author discusses issues inherent in Emily Dickinson's effort to define herself and to perceive truthfully the milieu in which she experienced life. To appreciate Dickinson, one must not be offended by the reminder that she was a poetess.'' (Author/NL)

  17. Early growth response protein-1 mediates lipotoxicity-associated placental inflammation: Role in maternal obesity

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Obesity is associated with low-grade chronic inflammation, which contributes to cellular dysfunction promoting metabolic disease. Obesity during pregnancy leads to a pro-inflammatory milieu in the placenta; however, the underlying causes for obesity-induced placental inflammation remain unclear. H...

  18. The effects of pre- and probiotics on the host immune response

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The gastrointestinal (GI) tract is the largest interface between an animal’s internal milieu and its exterior environment. As such, it forms a physical barrier between both environments. However, the function of the GI tract in the well-being of an animal is more complex than this passive role. T...

  19. Fostering Scholarship Capacity: The Experience of Nurse Educators

    ERIC Educational Resources Information Center

    Cash, Penelope A.; Tate, Betty

    2012-01-01

    In a milieu where traditional views of scholarship are embedded in the culture of educational institutions, and nursing programs in particular, this paper reports on a research project designed to support nurse educators' capacity to engage in scholarly activities. Rogers' (2003, 2004) "Diffusion of Innovation" model provided a…

  20. "Why Girls Go Wrong": Advising Female Teen Readers in the Early Twentieth Century

    ERIC Educational Resources Information Center

    Pierce, Jennifer Burek

    2007-01-01

    This article traces historical uses of the phrase "why girls go wrong" to provide a context for analysis of Progressive Era reading guidance for girls and then turns to actual girls' responses to reading. The historic context depicts the milieu in which young women and the advisors who sought to guide them lived and read as a time of intense…

  1. Towards a Pedagogy of a New Social Contract: Lessons from the Participatory Budget in the State of Rio Grande do Sul (Brazil)

    ERIC Educational Resources Information Center

    Streck, Danilo Romeu

    2004-01-01

    The paper analyses the pedagogical dimension of the process of Participatory Budgeting in the State of Rio Grande do Sul (Brazil), taking into consideration the local and regional culture as well as the wider political milieu. The question this paper engages with is whether, in this social movement involving around 400,000 people in 2001, there…

  2. Towards a Pedagogy of a New Social Contract: Lessons from Participatory Budgeting in the State of Rio Grande do Sul (Brazil).

    ERIC Educational Resources Information Center

    Streck, Danilo R.

    This paper analyzes the pedagogical dimension within the process of participatory budgeting in the state of Rio Grande do Sul, Brazil, taking into consideration the local and regional culture, as well as the political milieu. The question is whether, in this social movement which involved around 400,000 people in 2001, signs can be identified that…

  3. Innovation in Late Medieval Educational Thought: Vincent of Beauvais, Ramon Lull, and Pierre Dubois.

    ERIC Educational Resources Information Center

    McCarthy, Joseph M.

    The agenda of 13th and 14th century educational theorists embraced issues that stimulated innovation in educational theory and practice. Christian thinkers of the late middle ages were preoccupied with adapting their educational notions to the changing conditions of their socio-political milieu. The question of the training of Christian rulers…

  4. Impact of dietary fibers on nutrient management and detoxification organs: gut, liver, and kidneys

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Increased dietary fiber (DF) intake elicits a wide range of physiological effects, not just locally in the gut, but systemically. Dietary fibers can greatly alter the gut milieu by impacting the gut microbiome, which in turn influences the gut barrier, gastrointestinal immune and endocrine response...

  5. A Native American Voice in Multicultural Psychology: Finding Healing in an Interpersonal Tapestry

    ERIC Educational Resources Information Center

    Robbins, Rockey R.

    2012-01-01

    The tribal-cultural milieu in which the author was raised incited awareness that Native American people live in a great tapestry of life where everything and everyone is interconnected. It is an awareness that cannot be taught through lectures or books. It is an awareness of connectedness that Native American people had in early childhood but was…

  6. A New Breed of Social Studies Teachers? Or New School Systems?

    ERIC Educational Resources Information Center

    Wisniewski, Richard

    University education departments and teacher educators are not presently providing the innovative reform-minded milieu necessary to develop vital, deeply committed social studies teachers. Education degree programs are remarkably similiar in course requirements and format, emphasizing traditional lecture oriented courses and student teaching.…

  7. Comparing Cyberbullying and School Bullying among School Students: Prevalence, Gender, and Grade Level Differences

    ERIC Educational Resources Information Center

    Lapidot-Lefler, Noam; Dolev-Cohen, Michal

    2015-01-01

    Recent technological developments have added cyberspace as part of adolescents' social milieu. Bullying, which is prevalent in adolescents' social environment, also takes place in cyberspace, although it is believed to have a more potent and harmful effect. A study of cyberbullying and FtF bullying could elucidate critical implications for…

  8. Reconsidering Teacher Alienation: A Critique of "Teacher Burnout in the Public Schools."

    ERIC Educational Resources Information Center

    Vavrus, Michael

    1987-01-01

    Research on teacher burnout, stress, and alienation lacks emphasis on the social milieu in which teachers work. In his book, Anthony Dworkin adopts the subjective approach, eliminating any analysis of actual teacher working conditions. Furthermore, he muddles Marx's theory of alienation of labor. (Author/BJV)

  9. Succession planning for RNs: implementing a nurse management internship.

    PubMed

    Wendler, M Cecilia; Olson-Sitki, Kristi; Prater, Marsha

    2009-01-01

    The nursing shortage affects all levels, including the pivotal role of nurse managers, who may find themselves functioning in a complex, stressful work environment. In this increasingly difficult milieu, succession planning for nurse manager turnover is imperative. The authors describe an evidence-based, theoretically driven nurse management internship that allows staff nurses to explore the nurse manager role.

  10. Sex and Occupational Socialization among Prison Guards: A Longitudinal Study.

    ERIC Educational Resources Information Center

    Crouch, Ben M.; Alpert, Geoffrey P.

    1982-01-01

    Reports changes in attitudes of male and female prison guards over the first six months on the job. Found male guards became more, and female guards became less, punitive and aggressive. Results appear to derive from differences in the work milieu of male and female guards. (Author/JAC)

  11. The Scriptural Cantatas "Esther" and "Jacob, et Rachel" of Elisabeth-Claude Jacquet de La Guerre: Historical Context and Performance Practice

    ERIC Educational Resources Information Center

    Buckley, Elizabeth M.

    2009-01-01

    This project explores two sacred cantatas of Elisabeth-Claude Jacquet de La Guerre, "Esther" and "Jacob, et Rachel". The cultural milieu in which the sacred cantatas of Jacquet de La Guerre were written and performed will be discussed, as well as possible venues for their original performances, including the Parisian salon, and…

  12. Effects of Dose Frequency of Early Communication Intervention in Young Children with and without Down Syndrome

    ERIC Educational Resources Information Center

    Yoder, Paul; Woynaroski, Tiffany; Fey, Marc; Warren, Steven

    2014-01-01

    Children with intellectual disability were randomly assigned to receive Milieu Communication Teaching (MCT) at one 1-hr session per week (low dose frequency, LDF) or five 1-hr sessions per week (high dose frequency, HDF) over 9 months (Fey, Yoder, Warren, & Bredin-Oja, 2013. Non-Down syndrome (NDS) and Down syndrome (DS) subgroups were matched…

  13. Communication and Culture in Ancient India and China.

    ERIC Educational Resources Information Center

    Oliver, Robert T.

    The rhetorical theories and practices of ancient India and China provide the themes of this book. An examination of the relationship between culture and rhetoric, East and West, opens the book. The rhetorical milieu of India, its philosophy, social system, and uses of speech, leads to a probing of the caste system and speech of the Brahmins.…

  14. Prolepsis, Syncretism, and Synergy in Early Language and Literacy Practices: A Case Study of Family Language Policy in Singapore

    ERIC Educational Resources Information Center

    Ren, Li; Hu, Guangwei

    2013-01-01

    This article reports a case study of two Chinese-English bilingual families in Singapore and illustrates the importance of incorporating two hitherto disconnected fields of research--family language policy and family literacy practices--to an understanding of early language and literacy acquisition in the familial milieu. Specifically, this work…

  15. A RESEARCH DEMONSTRATION TO ASSESS THE EFFECTIVENESS OF A SPECIAL LIVING UNIT WITHIN A UNIVERSITY DORMITORY SETTING FOR THE REHABILITATION OF STUDENTS DISABLED BY EMOTIONAL DISTURBANCE.

    ERIC Educational Resources Information Center

    SINNETT, E. ROBERT

    USE OF A RESIDENCE HALL AS A THERAPEUTIC MILIEU FOR DISTURBED COLLEGE STUDENTS IS DESCRIBED IN THIS REPORT OF A RESEARCH AND DEMONSTRATION STUDY. THE EXPERIMENTAL GROUP CONSISTED OF TEN DISTURBED STUDENTS, AND A CONTROL GROUP WAS COMPOSED OF 10 VOLUNTEER STUDENTS. ALL STUDENTS PARTICIPATED IN THE REGULAR RESIDENCE HALL PROGRAMS (ORGANIZATIONAL…

  16. On the Nature of the Semiotic Structure of the Didactic Action: The Joint Action Theory in Didactics within a Comparative Approach

    ERIC Educational Resources Information Center

    Sensevy, Gérard; Gruson, Brigitte; Forest, Dominique

    2015-01-01

    In this paper, we first sketch the joint action theory paradigm from a general viewpoint in sciences of culture. Then we specify this generic description by focusing on the joint action theory in didactics (JATD). We elaborate on three currently developed elements of the theory: the reticence-expression dialectics; the contract-milieu dialectics,…

  17. Neurobiology of Sleep and Sleep Treatment Response in PTSD

    DTIC Science & Technology

    2009-10-01

    nightmares, dreaming and REM sleep may provide a unique psychophvsiological milieu dur- lllg which traumatic memories can he reexperienced in the absence of...physioiogiccli arousal. This process could f,lCilitate the attenuation of emotional and physio- logical responses associated with these memories ...subserving emotional processing and integration of trauma- related memories . Specifically, it is suggested that REM sleep provides a unique

  18. Work-Sport Competition: The Role of Agricultural Contests in New Zealand

    ERIC Educational Resources Information Center

    Tipples, Rupert; Wilson, Jude

    2007-01-01

    Contests that take place within the rural milieu have tended to be ignored. Yet a wide range of contests are associated with the rural/agricultural lifestyle. In New Zealand, for example, there are contests which judge specialised agricultural skills such as shearing, fencing, wood chopping or pruning, as well as those which assess assorted skills…

  19. Bringing New Historicism into the American Literature Survey.

    ERIC Educational Resources Information Center

    Jones, Margaret Faye

    2000-01-01

    Notes that students can begin to learn that literature is not a dead art with no relevance to them by studying works that provide a wider context that will allow readers a new sense of the cultural milieu in which texts are written and read in conjunction with the ones in their course anthologies. (SC)

  20. Social Structure of a Psychiatric Ward for Adolescents and the Therapeutic Implications of Patient-Staff and Intra-Staff Conflicts.

    ERIC Educational Resources Information Center

    Amini, Fariborz; And Others

    1978-01-01

    A system of staff and patient-staff meetings was initiated to clarify the psychodynamics of ward interactions and to reduce conflicts. Observations were made on the program's effect on the therapeutic milieu. It was concluded that the program failed because the adolescent patients felt threatened by over-analysis. (SJL)

  1. Identity Formation of American Indian Adolescents: Local, National, and Global Considerations

    ERIC Educational Resources Information Center

    Markstrom, Carol A.

    2011-01-01

    A conceptual model is presented that approaches identity formation of American Indian adolescents according to 3 levels of social contextual influence--local, national, and global--relative to types of identity, dynamics of identity, and sources of influence. Ethnic identity of American Indians is embedded within the local cultural milieu and…

  2. Commodification of Ghana's Volta River: An Example of Ellul's Autonomy of Technique

    ERIC Educational Resources Information Center

    Agbemabiese, Lawrence; Byrne, John

    2005-01-01

    Jacques Ellul argued that modernity's nearly exclusive reliance on science and technology to design society would threaten human freedom. Of particular concern for Ellul was the prospect of the technical milieu overwhelming culture. The commodification of the Volta River in order to modernize Ghana illustrates the Ellulian dilemma of the autonomy…

  3. Teaching Poetry: The Neglected Muse.

    ERIC Educational Resources Information Center

    Perricone, Catherine R.

    1978-01-01

    A discussion of six techniques whereby the abstract nature of foreign language poetry may be communicated to students. These are introduction to the genre, understanding and appreciating poetry, the poet and his/her milieu, reading for expression and vocabulary and in context, and analysis for theme, content, and structure. (Author/AMH)

  4. Argumentation in the Canadian House of Commons on the Issue of Nuclear Weapons for Canada.

    ERIC Educational Resources Information Center

    Jones, John Alfred

    The Cuban missile crisis of October 1962 forced the Canadian House of Commons to consider whether Canadian forces in NORAD and NATO were effective without nuclear warheads on special weapons systems. This paper provides an overview of the debates and their milieu, identifies the issues involved, and analyzes the effects of the argumentation. The…

  5. "The Storyteller: Reflections on the Works of Nikolai Leskov."

    ERIC Educational Resources Information Center

    International Journal of Oral History, 1981

    1981-01-01

    Presents 11 selections from Walter Benjamin's essay "The Storyteller" which illustrate how the work milieu and the significance of death are incorporated into stories. Benjamin compares historiography to traditional storytelling, and discusses the effect of the storyteller's need to maintain the listener's interest upon the story's style…

  6. Fostering Activities of Daily Living by Intact Nursing Home Residents

    ERIC Educational Resources Information Center

    Blair, Charles E.; Glaister, Judy; Brown, Alston; Phillips, Carolyn

    2007-01-01

    We assessed effectiveness of four education programs in providing nursing assistants with ability to produce a therapeutic milieu supportive of intact residents' activities of daily living, positive self-esteem and mood: (1) a combination of Orem's Systems of Nursing Care and Skinner's Applied Behavioral Analysis, (2) Applied Behavioral Analysis,…

  7. A Reflective Conversation with Kobus Maree, Faculty of Education, University of Pretoria, South Africa

    ERIC Educational Resources Information Center

    Shaughnessy, Michael F.; Moore, Tammy Lynne; Maree, Kobus

    2013-01-01

    Always regarded as somewhat of an "outsider" (the child of an English-speaking (Catholic) mother and an Afrikaans (Protestant) father in an exclusively Afrikaans milieu) and growing up extremely poor, seeing the hardship of others and realising how much talent was going to waste, Kobus Maree took a particular interest in gifted…

  8. Using a Cost-Construction Model To Assess the Cost of Educating Undergraduate Medical Students at the University of Texas-Houston Medical School.

    ERIC Educational Resources Information Center

    Franzini, Luisa; And Others

    1997-01-01

    Using a cost-construction model, cost of the University of Texas-Houston Medical School program, instructional costs, educational costs, and milieu costs were calculated. Sensitivity analysis revealed the financial effects of various factors, some of which increased and some of which decreased cost. Despite inherent complexities of the method and…

  9. Trude Weiss-Rosmarin: Rebel with a Cause.

    ERIC Educational Resources Information Center

    Reed, Barbara Straus

    1995-01-01

    Profiles Trude Weiss-Rosmarin, a German-Jewish immigrant to America who, in 1935, published an independent magazine of Jewish ideas. Notes that the periodical focused on Jewish survival in an assimilationist milieu and the role of Jewish women. States that Weiss-Rosmarin lectured frequently, attracted important readers, and contributed…

  10. Object Interest in Autism Spectrum Disorder: A Treatment Comparison

    ERIC Educational Resources Information Center

    McDuffie, Andrea S.; Lieberman, Rebecca G.; Yoder, Paul J.

    2012-01-01

    A randomized control trial comparing two social communication treatments for children with autism spectrum disorder examined the effect of treatment on object interest. Thirty-two children, 18-60 months, were randomly assigned to the Picture Exchange Communication System (PECS) or Responsive Education and Prelinguistic Milieu Teaching (RPMT)…

  11. Emotional Sequelae of Abortion: Implications for Clinical Practice.

    ERIC Educational Resources Information Center

    Lemkau, Jeanne Parr

    1988-01-01

    Summarizes literature on normative reactions to abortion and factors that increase risk of negative emotional sequelae. Discusses characteristics of woman, social support and cultural milieu around the abortion, the medical environment and abortion procedure itself, and events subsequent to abortion which may cause conflict. Discusses implications…

  12. Teacher Dispositions and Contract Non-Renewal

    ERIC Educational Resources Information Center

    Nixon, Andy; Dam, Margaret; Packard, Abbot

    2010-01-01

    School principals sift through a milieu of data, perceptions, and circumstances to determine which teachers are worthy of contract renewal. This paper provides a review of the research on the role that teacher dispositions play in principals' decision-making regarding contract renewals, as well as a theoretical perspective on the implications for…

  13. Techniques for Teaching Standard English Composition to English as a Second Dialect Students.

    ERIC Educational Resources Information Center

    Edwards, Thomas O.

    English as a second dialect (ESD) students are those who have developed linguistic patterns from their parents and other members of their cultural milieu. Since the ESD students seldom find themselves in a setting that demands the use of standard English, they come to higher education with a well developed linguistic pattern that is alien to…

  14. A "Prepaid Package" for Obstetrics: Effect on Teaching and Patient Care in a University Hospital

    ERIC Educational Resources Information Center

    Young, Philip E.

    1976-01-01

    The changing social milieu has removed the charity patient but not the need for a teaching population. The University Hospital's program is described, in which patients prepaid a fixed, single fee for all obstetrics-related care through the third post partum day. (LBH)

  15. The Three-legged Stool of Parental Inclusion: The Case of Hana

    ERIC Educational Resources Information Center

    Cobb, Cam

    2014-01-01

    Drawing from a critical qualitative inquiry, this case study tells the story of Hana, a Korean-Canadian mother, and identifies barriers that can be encountered in seeking to interact with school professionals in the special education milieu. The case study presents a conceptual model, called the three-legged stool of parental inclusion, which is…

  16. Effects of the Teach-Model-Coach-Review Instructional Approach on Caregiver Use of Language Support Strategies and Children's Expressive Language Skills

    ERIC Educational Resources Information Center

    Roberts, Megan Y.; Kaiser, Ann P.; Wolfe, Cathy E.; Bryant, Julie D.; Spidalieri, Alexandria M.

    2014-01-01

    Purpose: In this study, the authors examined the effects of the Teach-Model-Coach-Review instructional approach on caregivers' use of four enhanced milieu teaching (EMT) language support strategies and on their children's use of expressive language. Method: Four caregiver-child dyads participated in a single-subject, multiple-baseline study.…

  17. Leonard Cohen: Suzanne. Kritische Anmerkungen zur Interpretation (Critical Comments on Interpretation)

    ERIC Educational Resources Information Center

    Faulstich, Werner

    1977-01-01

    Criticizes a critique by J. Marsden of Leonard Cohen's pop song "Suzanne" as material for high school foreign language teaching. States that Marsden's article is concerned only with the text. The music agrees with the theme (loneliness) and with the "social milieu." (Text is in German.) (IFS/WGA)

  18. Cultural and Social Capital and Talent Development: A Study of a High-Ability Aboriginal Student in a Remote Community

    ERIC Educational Resources Information Center

    Kostenko, Karen; Merrotsy, Peter

    2009-01-01

    During the course of a school year, a study was conducted on the cultural context, the social milieu and the personal characteristics of a high ability Aboriginal student in a remote community in Canada. Using the lenses of cultural capital, social capital and human capital, the study explores the development of the student's talent through his…

  19. Trust Development in Outdoor Leadership

    ERIC Educational Resources Information Center

    Shooter, Wynn; Paisley, Karen; Sibthorp, Jim

    2010-01-01

    Establishing trusting relationships between leaders and participants is one way that outdoor leaders can create an emotionally safe and productive milieu that supports the attainment of desirable outcomes. Multidisciplinary literature offers considerable insight into leader trust development and the outcomes that are linked to trust in a leader.…

  20. Synchrotron Radiation Based Study of X-Ray Absorption of Flame Generated Nanoparticles

    DTIC Science & Technology

    2007-11-02

    induced ionization of nanoparticles, a proposal was prepared for submission to the French Government sponsored Programme Nationale du Physico- Chimie du...by the European Synchrotron Radiation Facility and by the French Programme Nationale du Physico- Chimie du Milieu Interstellaire. Special thanks are due

  1. Shyness and the College Admission Process: Who is Being Left Out?

    ERIC Educational Resources Information Center

    Hanley, Jr., Thomas A.

    2005-01-01

    As professionals on both sides of the admission desk, there are several questions we should ask ourselves with regard to this issue. For example, do outgoing students make more positive contributions to the academic milieu and social fabric of a university than reserved students??or are their contributions simply more visible? Do college…

  2. Self-Determination in Medical Education: Encouraging Medical Educators to Be More like Blues Artists and Poets

    ERIC Educational Resources Information Center

    Patrick, Heather; Williams, Geoffrey C.

    2009-01-01

    Historically, medical education has focused largely on medical students' intellectual development, mostly ignoring the broader psychological milieu of medical practice. This chasm can result in practitioners who are less likely to process their emotions and/or support their patient's needs, and more likely to experience burnout. Self-determination…

  3. Lesbian Mothers.

    ERIC Educational Resources Information Center

    Green, G. Dorsey

    Clinical interest in lesbian mothers has begun to emerge from the closet in recent years. Culture has dictated the milieu in which lesbian parents live and has prevented most therapists from being able to respond to lesbian parenting as a healthy option. In a heterosexist world, virtually all public displays of sexuality or family life are…

  4. Symposium: "Crash": Rhetorically Wrecking Discourses of Race, Tolerance, and White Privilege

    ERIC Educational Resources Information Center

    Nunley, Vorris L.

    2007-01-01

    From within the milieu of race and identity fatigue emerges "Crash." Winner of three Academy Awards, including Best Picture, "Crash" addresses how the fluidity of identity is pooled, ebbed, blocked, directed, dammed up. How identity and subjectivity are dammed up and mediated through the force of the anxieties, fears, and frustrations of people…

  5. Cholas, Mexican-American Girls, and Gangs.

    ERIC Educational Resources Information Center

    Harris, Mary G.

    1994-01-01

    Interviews with 21 present and former female gang members illustrate the lives of Mexican American girls in the gang milieu of the San Fernando Valley (Los Angeles, California). Gang structure, activities, and reasons for joining are discussed, along with the gang as a source of support. (SLD)

  6. Peddling Poverty for Profit: Elements of Oppression in Ruby Payne's Framework

    ERIC Educational Resources Information Center

    Gorski, Paul C.

    2008-01-01

    Ruby Payne, CEO of aha! Process, Inc., and author of "A Framework for Understanding Poverty" (2005), has become one of the most influential figures in the U.S. public education milieu. Payne's framework, built largely upon understanding the "culture" of poverty, instructs educators on the values and mindsets poor students carry into the classroom…

  7. Ravishing or Ravaged: Women's Relationships with Women in the Context of Aging and Western Beauty Culture

    ERIC Educational Resources Information Center

    Gosselink, Carol A.; Cox, Deborah L.; McClure, Sarissa J.; De Jong, Mary L. G.

    2008-01-01

    We undertook this narrative analysis study to explore the complexities of women's relationships with other women within the sociocultural milieu of beautyism and ageism. Using an open-ended narrative framework, four focus groups of women living in different regions throughout the U.S. were conducted and analyzed to identify thematic categories…

  8. The Bear and the Foxes Understanding Soviet Policy in the Warsaw Pact.

    DTIC Science & Technology

    1981-06-01

    embraces the xeno- phobia , anti-intellectualism and anti-democratic traditions of old Moscow. The unique cultural milieu of the peasant village and the...be synony- mous with the extinction of the socialist system. It is the catastrophic consequences of defeat which motivates the Soviet Union to

  9. School-Parent Relations in Lebanon

    ERIC Educational Resources Information Center

    El Majzoub, Nada

    2013-01-01

    Lebanon is a nation whose history may be depicted as continuous social, political, and sectarian conflict due to European political meddling and a protracted civil war. Although finding common ground in this complex milieu over the past several decades has been challenging, political and educational reforms have been enacted. The role of parents…

  10. Language Shift in the Tamil Communities of Malaysia and Singapore.

    ERIC Educational Resources Information Center

    Schiffman, Harold F.

    1995-01-01

    Examines the position of Tamil as the language of an ethnic minority in Malaysia and Singapore, placing the issue of Tamil and language maintenance within the larger sociolinguistic milieu in the two countries and drawing conclusions about the role of language policy and planning in the determination of linguistic outcomes. (SM)

  11. Sociocultural Factors in Client-Counsellor Self-Disclosure in Nigeria, Africa

    ERIC Educational Resources Information Center

    Oluwatosin, S. A.

    2014-01-01

    This paper reviews various factors that interplay in the counselling sessions within the cultural milieu of African society, especially Nigeria and particularly within the context of school-based counselling provision. These factors, which were found to be both sociological and cultural, hamper effective client self-disclosure during counselling…

  12. Challenges for Curriculum Leadership in Contemporary Teacher Education

    ERIC Educational Resources Information Center

    Parkes, Robert J.

    2013-01-01

    This paper outlines the complex contemporary milieu of Australian teacher education within which curriculum leaders responsible for designing teacher education programs must make their program design decisions. Particular attention is paid to the collision of vertical ("hierarchical" or "academic rationalist") and horizontal…

  13. A Case for Inserting Community into Public School Curriculum

    ERIC Educational Resources Information Center

    Theobald, Paul

    2006-01-01

    This essay contends that there are fundamental connections between a nation's political arrangements and its educational efforts on behalf of youth. Though the common school architects of the nineteenth century recognized these connections, they were profoundly forgotten in a later Darwinian milieu that suggested--our allegiance to democracy…

  14. Developing Multiliteracies through Bilingual Education in Burkina Faso

    ERIC Educational Resources Information Center

    Lavoie, Constance

    2008-01-01

    Being literate involves being able to move from the ability to read and write to include different forms of knowledge and modes of communication of the milieu (drumming, dancing, story-telling, etc.). This article examines the new literacy allowed through the existence of two types of schools (bilingual and monolingual) in Burkina Faso, in West…

  15. Teaching Prelinguistic Communication Skills to School Age Children with Autism

    ERIC Educational Resources Information Center

    Franco, Jessica Hetlinger

    2008-01-01

    Prelinguistic Milieu Teaching (PMT) is an intervention designed to teach young children to initiate nonverbal communication using vocalizations, gestures, and eye-gaze. Children are taught through social routines in their natural environment. Techniques include contriving an environment in which the children will be motivated to communicate and…

  16. Maternal Responsivity Predicts the Prelinguistic Communication that Facilitates Generalized Intentional Communication.

    ERIC Educational Resources Information Center

    Warren, Steven F.; Yoder, Paul J.

    1998-01-01

    This study examined whether maternal responsivity would predict the extent to which prelinguistic milieu teaching (PMT) facilitated generalized intentional communication better than a contrast small-group treatment with 58 children (ages 17 to 36 months) with developmental disabilities. If mothers were relatively responsive before treatment, PMT…

  17. Increasing Communication in Children with Concurrent Vision and Hearing Loss

    ERIC Educational Resources Information Center

    Brady, Nancy C.; Bashinski, Susan M.

    2008-01-01

    Nine children with complex communication needs and concurrent vision and hearing losses participated in an intervention program aimed at increasing intentional prelinguistic communication. The intervention constituted a pilot, descriptive study of an adapted version of prelinguistic milieu teaching, hence referred to as A-PMT. In A-PMT, natural…

  18. Behavioral Management Leads to Reduction in Aggression in a Child and Adolescent Psychiatric Inpatient Unit

    ERIC Educational Resources Information Center

    Dean, Angela J.; Duke, Suzanne G.; George, Michelle; Scott, James

    2007-01-01

    Objective: Aggression is common in children and adolescents admitted to psychiatric inpatient units. Few interventions for reducing aggressive behaviors have been identified. This study aimed to evaluate the impact of a milieu-based behavioral management program on the frequency of aggressive behaviors in a child and adolescent mental health…

  19. Education and Practice Barriers for Certified Registered Nurse Anesthetists.

    PubMed

    Malina, Debra P; Izlar, Janice J

    2014-05-31

    Of the recognized advanced practice registered nursing (APRN) specialties, Certified Registered Nurse Anesthetists (CRNAs) have historically experienced the most vigorous and organized resistance from outside entities regarding rights to practice to the full scope of their education and experience. Opposition to nurse anesthetists practicing to the full scope of their education and training is present in the clinical arena and educational milieu.

  20. Mice fed a high-fat diet supplemented with resistant starch display marked shifts in the liver metabolome concurrent with altered gut bacteria

    Technology Transfer Automated Retrieval System (TEKTRAN)

    High-amylose maize resistant starch type 2 (HAMRS2) is a fermentable dietary fiber known to alter the gut milieu, including the gut microbiota, which may explain reported effects of resistant starch to ameliorate obesity-associated metabolic dysfunction. Our working hypothesis is that HAMRS2-induced...

  1. Dynamic Assessment of Graphic Symbol Combinations by Children with Autism.

    ERIC Educational Resources Information Center

    Nigam, Ravi

    2001-01-01

    This article offers teaching strategies in the dynamic assessment of the potential of students with autism to acquire and use multiple graphic symbol combinations for communicative purposes. Examples are given of the matrix strategy and milieu language teaching strategies. It also describes the Individualized Communication-Care Protocol, which…

  2. Urbanism from the Perspective of Ecological Psychologists

    ERIC Educational Resources Information Center

    Gump, Paul V.; Adelgerg, Bettina

    1978-01-01

    A perception of ecological psychology on urbanism is presented, with emphasis on the following premises: (1) Urban milieu consists of complexes of behavior settings; and (2) Size of a city should be understood in relationship to the number and variety of its settings, rather than in terms of population size. (Author/MA)

  3. A Case for Naturalistic Assessment of Reading Comprehension.

    ERIC Educational Resources Information Center

    Moore, David W.

    1983-01-01

    Presents a historical overview of the introduction of the major reading comprehension assessments, showing that the predominant approaches were shaped by the prevailing educational measurement milieu and were implemented largely in response to public pressure. Argues in favor of a naturalistic reading comprehension assessment for evaluating those…

  4. A Randomized Comparison of the Effect of Two Prelinguistic Communication Interventions on the Acquisition of Spoken Communication in Preschoolers with ASD

    ERIC Educational Resources Information Center

    Yoder, Paul; Stone, Wendy L.

    2006-01-01

    Purpose: This randomized group experiment compared the efficacy of 2 communication interventions (Responsive Education and Prelinguistic Milieu Teaching [RPMT] and the Picture Exchange Communication System [PECS]) on spoken communication in 36 preschoolers with autism spectrum disorders (ASD). Method: Each treatment was delivered to children for a…

  5. Piaget Versus Materialism: A Concordance of the Discordance.

    ERIC Educational Resources Information Center

    Burger, Henry G.

    The purpose of this paper is to disconfirm Piaget's theory of an invariant sequence of intellectual maturation for all youths in all cultures. The author's view is that the kinds and sequences of human development vary greatly, depending on the cultural milieu. The author derives 36 propositions from Piaget's theory, dismisses 5 of them as…

  6. Harmonizing the Educational Globe. World Polity, Cultural Features, and the Challenges to Educational Research

    ERIC Educational Resources Information Center

    Trohler, Daniel

    2010-01-01

    The general thesis of this paper is that the motives of the currently dominant global educational governance are rooted in a specific cultural milieu in the time of the Cold War, more precisely in the late 1950s, heading to a harmonious world. The more specific thesis is that a series of failures in the achievement of this harmonized globe led to…

  7. Jean-Marie Straub.

    ERIC Educational Resources Information Center

    Roud, Richard

    This book covers the life and aesthetic qualities of the work of the European film-maker Jean-Marie Straub (1933- ). It contains introductory chapters on the biography and artistic milieu of Straub and continues with a chapter-by-chapter critical treatment of each of his films: "Machorka-Muff"; "Not Reconciled"; "Chronicle…

  8. Left-Wing Tragedy or Comic Opera?: A New Look at the Demise of "The Masses".

    ERIC Educational Resources Information Center

    Heinze, Kirk

    Although the suppression in 1917 of "The Masses," an influential Socialist magazine, has been depicted as an American tragedy, such a narrow interpretation ignores the bizarre, confused, often comic developments and episodes that attended the magazine's end. A reexamination of the demise of "The Masses" has been made to show the milieu in which…

  9. The Learning Combination Lock--An Experiential Approach to Learning Design.

    ERIC Educational Resources Information Center

    Wilson, John P.; Beard, Colin

    2003-01-01

    An experiential learning model based on information processing is the foundation for the learning combination lock model, which depicts how six factors (or tumblers) may be selected and combined to develop effective learning opportunities. The factors are places and elements, milieu, senses, emotions, forms of intelligence, and ways of learning.…

  10. The Evolution of Library Outreach 1960-75 and Its Effect on Reader Services: Some Considerations. Occasional Paper Number 16.

    ERIC Educational Resources Information Center

    Weibel, Kathleen

    The literature of American public library outreach services over a 15-year period is reviewed in the context of the War on Poverty milieu and the four functions of reader services: information, instruction, guidance, and stimulation to use. Three formats were typically present in this literature: broad statements of need, justifications of…

  11. From Command to Constructivism: Canadian Secondary School Physical Education Curriculum and "Teaching Games for Understanding"

    ERIC Educational Resources Information Center

    Singleton, Ellen

    2009-01-01

    Canadian physical educators have fought long and hard to be recognized as legitimate contributors to school curricula. In claiming alliances with discourses of medicine and morality, science and psychology, proponents of physical education have sought to be recognized and validated within the educational milieu. These claims have fundamentally…

  12. Grand Designs! Analysing the Conceptual Tensions Associated with New Physical Education and Health and Well-Being Curriculum

    ERIC Educational Resources Information Center

    Thorburn, Malcolm; Horrell, Andrew

    2014-01-01

    The positioning of physical education in the school curriculum continues to reflect external discourses circulating in political and social milieu. As increasing austerity measures influence and restrict educational priorities, we consider that there is an urgent need for physical educationalists to articulate a rationale for an educational…

  13. Development of pre-implantation porcine embryos cultured within alginate hydrogel systems either supplemented with secreted phosphoprotein 1 or conjugated with arg-gly-asp peptide

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Although deficiencies in porcine embryo elongation play a significant role on early embryonic mortality and establishment of within–litter developmental variation, the exact mechanisms of elongation are poorly understood. Secreted phosphoprotein 1 (SPP1) is increased within the uterine milieu during...

  14. Human Development Theories and Their Applicability to the Middle School Program. A Position Paper.

    ERIC Educational Resources Information Center

    Jordan, Lois E.

    This paper examines theories of human development within the context of the models presented by the schools of cognitive learning, behavioralism, psychoanalysis, and humanistic views of growth. Stress is placed on the stages of human development that provides a means of better meeting the needs of students ages 10-14 in the middle school milieu.…

  15. Beyond an Initial Campus Heritage Survey: Creating an Infrastructure for Renewal

    ERIC Educational Resources Information Center

    Neuman, David J.

    2011-01-01

    Given their value to the student experience, institutional identity, alumni loyalty, and economic welfare, historic preservation efforts must unite with institutional sustainability efforts and other high priorities to develop an approach for mutual success. Further, it is important to recognize the limits in the current milieu of economic…

  16. Matching the Student with the Most Appropriate Assistive Technology: Evaluation of the Assistive Technology Device Predisposition Assessment (ATD PA).

    ERIC Educational Resources Information Center

    Scherer, Marcia J.; McKee, Barbara G.

    To those who look to technology to enhance a person's quality of life and not merely to restore capability, it is more important and cost effective to consider environmental modifications and the functions of devices within a comprehensive context of varying situations (Milieu characteristics); user interests, needs, capabilities, expectations,…

  17. Hormonal profile impact on female sexual function in young women

    NASA Astrophysics Data System (ADS)

    Stoian, Dana; Craciunescu, Mihalea; Craina, Marius; Pater, Liana; Pater, Flavius

    2014-12-01

    Female sexual function is dependent, in physiological milieu upon hormonal impulses: estradiol, testosterone, cortisol, progesterone, prolactin and TSH. Out study tries to appreciate the impact of testosterone, estradiol and prolactin, the major hormones involved in the sexual response, on the normal sexual function. This parameter is approximated by the value of the total FSFI score, a validated international structured interview.

  18. Tracing Lines of Meaning: A Course Redesign for Dance Pedagogy

    ERIC Educational Resources Information Center

    Enghauser, Rebecca Gose

    2012-01-01

    The 21st-century dance milieu demands that a dancer possess a highly diverse skill set, including effective teaching skills and a broader appreciation of a pedagogical orientation. It is vital that in preparing dance educators, we create opportunities for students to reflect on their dance learning histories and consequential beliefs about…

  19. Heparin-induced thrombocytopaenia.

    PubMed

    Gounden, Ronald; Blockman, Marc

    2008-01-01

    Heparin-induced thrombocytopaenia (HIT) is an acquired, transient prothrombotic disorder caused by heparin. The predominant problem is the creation of a prothrombotic milieu, accompanied by a fall in the platelet count. This explains the apparent paradox of thrombosis in the face of thrombocytopaenia and why non-heparin antithrombotic agents are integral to its management.

  20. Tensions in Defining Quality Pre-School Education: The Singapore Context

    ERIC Educational Resources Information Center

    Lim-Ratnam, Christina

    2013-01-01

    Over the past decade, the government in Singapore has been introducing many initiatives in the early childhood sector to raise the quality of pre-school education. Educational reforms made without consideration of the perspectives and concerns of the participants in the socio-cultural milieu would only lead to superficial implementation. This…

  1. Canadian Books for Children.

    ERIC Educational Resources Information Center

    McDonough, Irma, Ed.

    The children's books listed and annotated in this book were selected by Canadian children's librarians; they represent the most informative and relevant books in print for children, providing knowledge and understanding of the Canadian environment and cultural milieu. Each entry indicates bibliographic information and availability.…

  2. US Higher Education in a Budgetary Vortex--1992-2007: Tracing the Positioning of Academe in the Context of Growing Inequality

    ERIC Educational Resources Information Center

    de Oliver, Miguel; Briscoe, Felecia M.

    2011-01-01

    Through comparative statistical data of public investment trends in higher education, the institution of higher education in the US is contemporarily contextualized within the growing milieu of disparity. Specifically, this study focuses on the period from 1992 to 2007 to see if a mitigation of the growing economic disparity projected per the…

  3. The Experience of Initial Management Training in ELT

    ERIC Educational Resources Information Center

    Rimmer, Wayne

    2016-01-01

    Management training in ELT organizations is often inadequate. New managers are in severe need of training, especially for tasks which are non-pedagogical, yet they operate in a milieu where there are few opportunities for support compared with colleagues in mainstream education. The purpose of this case study, a rare evidence-based contribution to…

  4. Question-Asking and Question-Exploring

    ERIC Educational Resources Information Center

    Sands, Lorraine; Carr, Margaret; Lee, Wendy

    2012-01-01

    The Centre of Innovation Research at Greerton Early Childhood Centre was characterised as a dispositional milieu where working theories were explored through a narrative research methodology. As the research progressed, the teachers at Greerton strengthened the way we were listening to, and watching out for young children's questions to enable…

  5. Some Comments on Analytic Traditions in EFA As against CFA: An Analysis of Selected Research Reports.

    ERIC Educational Resources Information Center

    Kieffer, Kevin M.

    Factor analysis has historically been used for myriad purposes in the social and behavioral sciences, but an especially important application of this technique has been to evaluate construct validity. Since in the present milieu both exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) are readily available to the researcher,…

  6. Design Milieux for Learning Environments in African Contexts

    ERIC Educational Resources Information Center

    Duveskog, Marcus; Sutinen, Erkki; Cronje, Johannes

    2014-01-01

    During the years 2002 to 2009, five African settings were used as foundation for designing different learning environments. While the content and target group for each learning environment varied, all of their design settings, or milieux, shared one implicit expectation: the milieu should facilitate the production of a change-making learning…

  7. Moderate Pluralism: Beyond a Reasonable Liberalism to Recognition of Cultural Expertise

    ERIC Educational Resources Information Center

    Fraser-Burgess, Sheron

    2010-01-01

    The growing diversity of school populations in the present education milieu raises issues of treating difference along multiple lines of the social, political and economic well being of children. Difference is here defined as politically significant group identities to which the author refers as cultures or identity groups. Political liberal…

  8. Elementary School Classroom Teacher Delivered Physical Education: Costs, Benefits and Barriers

    ERIC Educational Resources Information Center

    Sherman, Clay P.; Tran, Cynthia; Alves, Yara

    2010-01-01

    Given academic priorities and budgetary constraints in the current elementary school milieu, the classroom teacher will likely remain a primary physical education provider. Understanding classroom teachers' perspectives related to costs, benefits, and barriers to teaching physical education is essential to understanding physical education…

  9. "If You Don't Believe That You're Doing Some Good with the Work That You Do, Then You Shouldn't Be Doing It": An Interview with Cindy Selfe

    ERIC Educational Resources Information Center

    Bailie, Brian

    2010-01-01

    In this interview, Cindy Selfe talks about the intersections of technological literacy, digital scholarship, poststructuralist theory, and university politics. In doing so, she provides a lens for scholars trying to understand the milieu of the university by viewing its potential in juxtaposition to its past; explains how technology redefines the…

  10. Background Readings in American Education.

    ERIC Educational Resources Information Center

    Office of Education (DHEW), Washington, DC. Bureau of Research.

    This collection of readings was assembled and edited for use at the White House Conference on Education in Washington, D.C. on July 21st and 22nd, 1965. Some of the twenty-nine documents of historical value and relevance in today's educational milieu are: 1) Proposals Relating to the Education of Youth in Pennsylvania, Benjamin Franklin, 1749; 2)…

  11. Perceptions of Teacher Collegial Work Groups at the Department Level in Southern California

    ERIC Educational Resources Information Center

    Guerrero, Frank C.

    2012-01-01

    Since the inception of a "Nation at Risk" (1983) and the gradual growth of the school reform movement over the following several decades, the social and political milieu that exist today under No Child Left Behind (NCLB) can be best described as an era in which public education is fending itself from extinction and takeover, often from…

  12. Sociology of Twentieth Century Congregate Care of the Developmentally Disabled-Recollections

    ERIC Educational Resources Information Center

    Daly, William C.

    2005-01-01

    Elements of the twentieth century care facility of state origin are enumerated as the reader hopefully gets some idea of the social milieu or ethos of that period and the management profile thought to be proper and expeditious for unfortunate, homeless and poorly adjusted citizens. The life of staff and patients within these state sponsored…

  13. Hard-Core Unemployment: A Selected, Annotated Bibliography.

    ERIC Educational Resources Information Center

    Cameron, Colin, Comp.; Menon, Anila Bhatt, Comp.

    This annotated bibliography contains references to various films, articles, and books on the subject of hard-core unemployment, and is divided into the following sections: (1) The Sociology of the Hard-Core Milieu, (2) Training Programs, (3) Business and the Hard-Core, (4) Citations of Miscellaneous References on Hard-Core Unemployment, (5)…

  14. Another day older and deeper in therapy: Can the Dynamic-Maturational Model offer a way out?

    PubMed

    Wilkinson, Simon R

    2010-07-01

    Patients referred to adolescent psychiatric units have often been in contact with services for many years. When assessing for admission we consider why the previous approaches might have failed and how milieu therapy might be more effective as the priority treatment. We propose that the information provided by an adolescent's Transition to Adulthood Attachment Interview (TAAI) and the parents' Adult Attachment Interviews (AAI) leads to an especially productive case formulation. The Dynamic-Maturational Model of attachment and adaptation (DMM) uniquely provides a detailed understanding of an extended range of Type A and Type C strategies with modifiers that are useful for planning the milieu therapy, individual and family work. In addition, this case presentation illustrates the usefulness of understanding the phenomenon of "intruded negative affect".

  15. In situ characterization of nanoparticle biomolecular interactions in complex biological media by flow cytometry

    PubMed Central

    Lo Giudice, Maria Cristina; Herda, Luciana M.; Polo, Ester; Dawson, Kenneth A.

    2016-01-01

    Nanoparticles interacting with, or derived from, living organisms are almost invariably coated in a variety of biomolecules presented in complex biological milieu, which produce a bio-interface or ‘biomolecular corona' conferring a biological identity to the particle. Biomolecules at the surface of the nanoparticle–biomolecule complex present molecular fragments that may be recognized by receptors of cells or biological barriers, potentially engaging with different biological pathways. Here we demonstrate that using intense fluorescent reporter binders, in this case antibodies bound to quantum dots, we can map out the availability of such recognition fragments, allowing for a rapid and meaningful biological characterization. The application in microfluidic flow, in small detection volumes, with appropriate thresholding of the detection allows the study of even complex nanoparticles in realistic biological milieu, with the emerging prospect of making direct connection to conditions of cell level and in vivo experiments. PMID:27845346

  16. Electron microscope observations of impact crater debris amongst contaminating particulates on materials surfaces exposed in space in low-Earth orbit

    NASA Technical Reports Server (NTRS)

    Murr, L. E.; Rivas, J. M.; Quinones, S.; Niou, C.-S.; Advani, A. H.; Marquez, B.

    1993-01-01

    Debris particles extracted from a small sampling region on the leading edge of the Long Duration Exposure Facility (LDEF) spacecraft have been examined by analytical transmission electron microscopy and the elemental frequency observed by energy-dispersive X-ray spectrometry and compared with upper atmosphere (Earth) particle elemental frequency and the average elemental compositions of interplanetary dust particles. A much broader elemental distribution was observed for the exposed spacecraft surface debris milieu. Numerous metal microfragment analyses, particularly aluminum and stainless steel, were compared with scanning electron microscope observations-of impact crater features, and the corresponding elemental spectra on selected LDEF aluminium tray clamps and stainless steel bolts. The compositions and melt features for these impact craters and ejecta have been shown to be consistent with microcrystalline debris fragments in the case of aluminum, and these observations suggest an ever changing debris milieu on exposed surfaces for space craft and space system materials.

  17. Protein bio-corona: critical issue in immune nanotoxicology.

    PubMed

    Neagu, Monica; Piperigkou, Zoi; Karamanou, Konstantina; Engin, Ayse Basak; Docea, Anca Oana; Constantin, Carolina; Negrei, Carolina; Nikitovic, Dragana; Tsatsakis, Aristidis

    2017-03-01

    With the expansion of the nanomedicine field, the knowledge focusing on the behavior of nanoparticles in the biological milieu has rapidly escalated. Upon introduction to a complex biological system, nanomaterials dynamically interact with all the encountered biomolecules and form the protein "bio-corona." The decoration with these surface biomolecules endows nanoparticles with new properties. The present review will address updates of the protein bio-corona characteristics as influenced by nanoparticle's physicochemical properties and by the particularities of the encountered biological milieu. Undeniably, bio-corona generation influences the efficacy of the nanodrug and guides the actions of innate and adaptive immunity. Exploiting the dynamic process of protein bio-corona development in combination with the new engineered horizons of drugs linked to nanoparticles could lead to innovative functional nanotherapies. Therefore, bio-medical nanotechnologies should focus on the interactions of nanoparticles with the immune system for both safety and efficacy reasons.

  18. Vulvodynia and fungal association: a preliminary report.

    PubMed

    Ventolini, G; Gygax, S E; Adelson, M E; Cool, D R

    2013-08-01

    Vulvodynia (vulvar pain syndrome) is a chronic multifactorial disease affecting almost 13 million women in the USA and can lead to morbidity and a reduced quality of life. We hypothesize that an initial microbiological insult in the vagina causes modifications in the biological vaginal milieu and/or an alteration on the lactobacilli flora. The vaginal milieu responds to the insult by developing an inflammatory reaction with abnormal cytokine production. These hypotheses were tested quantifying vaginal lactobacillus and cytokines, in patients with vulvodynia compared to matched healthy controls. Our preliminary data suggest a vaginal flora alteration and an immunological response involving Candida in patients with vulvodynia. Ongoing studies will assist us to clarify these findings.

  19. In situ characterization of nanoparticle biomolecular interactions in complex biological media by flow cytometry

    NASA Astrophysics Data System (ADS)

    Lo Giudice, Maria Cristina; Herda, Luciana M.; Polo, Ester; Dawson, Kenneth A.

    2016-11-01

    Nanoparticles interacting with, or derived from, living organisms are almost invariably coated in a variety of biomolecules presented in complex biological milieu, which produce a bio-interface or `biomolecular corona' conferring a biological identity to the particle. Biomolecules at the surface of the nanoparticle-biomolecule complex present molecular fragments that may be recognized by receptors of cells or biological barriers, potentially engaging with different biological pathways. Here we demonstrate that using intense fluorescent reporter binders, in this case antibodies bound to quantum dots, we can map out the availability of such recognition fragments, allowing for a rapid and meaningful biological characterization. The application in microfluidic flow, in small detection volumes, with appropriate thresholding of the detection allows the study of even complex nanoparticles in realistic biological milieu, with the emerging prospect of making direct connection to conditions of cell level and in vivo experiments.

  20. The imperative of strategic alignment across organizations: the experience of the Canadian Cancer Society's Centre for Behavioural Research and Program Evaluation.

    PubMed

    Cameron, Roy; Riley, Barbara L; Campbell, H Sharon; Manske, Stephen; Lamers-Bellio, Kim

    2009-01-01

    The Canadian Cancer Society's Centre for Behavioural Research and Program Evaluation (CBRPE) is a national asset for building pan-Canadian capacity to support intervention studies that guide population-level policies and programs. This paper briefly describes CBRPE's experience in advancing this work in the field of prevention. The aim is to illuminate issues of central importance for advancing the goals of the Population Health Intervention Research Initiative for Canada. According to our experience, success in building the population intervention field will depend heavily on purposeful alignment across organizations to enable integration of research, evaluation, surveillance, policy and practice. CBRPE's capacity development roles include a) a catalytic role in shaping this aligned inter-organizational milieu and b) investing our resources in building tangible assets (teams, indicators, data systems) that contribute relevant capacities within this emerging milieu. Challenges in building capacity in this field are described.

  1. B lymphocyte immune response gene phenotype is genetically determined

    SciTech Connect

    Tse, H.Y.; Mond, J.J.; Longo, D.L.

    1982-04-01

    We examined the effects of the developmental milieu on the capacity of B cells to undergo immune response gene-controlled, T cell-dependent polyclonal proliferation. Although I-Aq poly(Glu60 Ala30 Tyr10)n (GAT)-nonresponder T cells developing in a responder environment become phenotypic GAT-responders, I-Aq B cells remain unresponsive to GAT, even after maturation in a GAT-responder animal. Conversely, (B10.A x B10.Q)F1 ((GAT responder x GAT nonresponder)F1) T cells developing in a B10.Q GAT nonresponder host fail to respond to GAT, but F1 B cells from the same F1 leads to parent chimeras make excellent proliferative responses in the presence of GAT and responder T cells. Thus, by this assay, B cell immune response gene function is genetically determined and is not affected by the developmental milieu.

  2. U.S.-Latin American Nuclear Relations: From Commitment to Defiance

    DTIC Science & Technology

    2012-09-01

    nuclear age .” The latter is a term used to characterize a milieu dominated by nuclear anxiety about horizontal nuclear proliferation in Iran and North...preferences. The report first presents the project research design and methods. The second and third sections discuss the background leading to...through the Atoms for Peace Program during the 1950s—a program conceived by the Eisenhower administration to assist Third World countries in developing

  3. The National Intelligence Strategy of the United States of America

    DTIC Science & Technology

    2014-01-01

    security issues , and ultimately, to make our nation more secure. We face significant changes in the domestic and global environment and must be...to the changing environment, and promotes best practices across the IC; • Provide a workplace free of discrimination, harassment , and the fear of...components, described as follows: (1) the Strategic Environment section portrays the global national security milieu; (2) the Mission Objective section

  4. Hormonal causes of recurrent pregnancy loss (RPL).

    PubMed

    Pluchino, Nicola; Drakopoulos, Panagiotis; Wenger, Jean Marie; Petignat, Patrick; Streuli, Isabelle; Genazzani, Andrea Riccardo

    2014-01-01

    Endocrine disorders play a major role in approximately 8% to 12% of recurrent pregnancy loss (RPL). Indeed, the local hormonal milieu is crucial in both embryo attachment and early pregnancy. Endocrine abnormalities, including thyroid disorders, luteal phase defects, polycystic ovary syndrome, hyperprolactinaemia and diabetes have to be evaluated in any case of RPL. Moreover, elevated androgen levels and some endocrinological aspects of endometriosis are also factors contributing to RPL. In the present article, we review the significance of endocrine disease on RPL.

  5. The Role of Sleep in the Health and Resiliency of Military Personnel

    DTIC Science & Technology

    2011-04-01

    Health and Well-Being across the Military Spectrum (Bien-être et santé mentale dans le milieu militaire). RTO-MP-HFM-205 14. ABSTRACT Sleep is a...than 85%, and 42% took longer than 30 minutes to fall asleep (Peterson et al., 2008). The Mental Health Advisory Team (MHAT) Reports V (OTSMNC-I...gender, lower reported general health , and reported mental health symptoms. Findings from a study of 130 injured service members with extremity trauma

  6. [Organizational culture and professional development in nursing].

    PubMed

    Ruiz Moreno, J

    1999-02-01

    There is a lot of talk about the importance of persons in organization and leadership, nothing that the keys to lead the organizational milieu in a positive and beneficial manner have been established for several decades. These keys are related to the values of nursing as a profession and to how these may constitute intangible assets. Nonetheless, identifying such values and intangible assets is not the exclusive responsibility of business managers in the nursing field.

  7. Effects of various pharmacological agents on the function of norepinephrine transporter.

    PubMed

    Satoh, Noriaki; Toyohira, Yumiko; Takahashi, Keita; Yanagihara, Nobuyuki

    2015-03-01

    The norepinephrine transporter is selectively expressed in noradrenergic nerve terminals, where it can exert spatial and temporal control over the action of norepinephrine. The norepinephrine transporter mediates the termination of neurotransmission via the reuptake of norepinephrine released into the extracellular milieu. In the present brief review, we report our recent studies about the effects of various pharmacological agents such as fasudil, nicotine, pentazocine, ketamine and genistein on norepinephrine transporter function.

  8. Dermal Wound Transcriptomic Responses to Infection with Pseudomonas aeruginosa versus Klebsiella pneumoniae in a Rabbit Ear Wound Model

    DTIC Science & Technology

    2014-05-02

    harvested on POD4 for microarray and transcriptome analysis. Other wounds received topical antibiotic after infection for 24 hours to promote biofilm ...cell toxicity in response to a more damaging P.a. inflammatory milieu. The POD6 wounds were colonized with biofilm but expressed magnitudes fewer...infection for 24 hours to promote biofilm development, and were harvested on POD6 or POD12. Results: Wounds infected for 24 hours, relative to uninfected

  9. The effects of light on man and other mammals

    NASA Technical Reports Server (NTRS)

    Wurtman, R. J.

    1975-01-01

    The present article describes the best-studied extravisual effects of visible and ultraviolet light on humans and other mammals. It also considers the possible biological consequences to man of living in artificially lighted environments that differ significantly from the milieu in which he evolved. Cumulative evidence favors the beneficial influences of sunlight: vitamin D activation, plasma bilirubin elimination, inhibition of pineal melatonin synthesis, etc.

  10. The relationship between treatment modality, demographic characteristics, and staff perceptions concerning their jobs in 26 Philadelphia drug treatment centers.

    PubMed

    Bausell, R B; Rinkus, A; Watson, D D

    1979-01-01

    The staffs of 26 Philadelphia drug treatment centers, representing four major treatment modalities, were interviewed concerning their attitudes and perceptions of treatment and the treatment milieu. By employing canonical correlation, two basic modality contrasts were found that significantly differentiated these attitudes and perceptions: (1) staff in small therapeutic communities tended to manifest more positive attitudes than their counterparts in large methadone maintenance settings, and (2) outpatient drug-free staff tended to be more satisfied and optimistic than detoxification staff.

  11. Fast Detection of Ciprofloxacin Resistance, Part I

    DTIC Science & Technology

    2005-10-01

    Public Health and the Environment (Rijksinstituut voor Volksgezondheid en Milieu) RNA Ribo-Nucleic Acid TSA Trypticase soy agar QRDR Quinolone resistance...the sequences of the DNA regions called Quinolone Resistance Determining Region (QRDR, Broekhuijsen and van Dijk, 2005) of three related genes were of...described a method for rapid detection of quinolone resistance- associated gyrA mutations in Neisseria gonorrhoeae. They also use the LightCycler

  12. Local and gay: addressing the health needs of Asian and Pacific Islander American (A/PIA) lesbians and gay men in Hawaii.

    PubMed

    Kanuha, V K

    1999-09-01

    Asian and Pacific Islander American lesbians and gay men, who are "local" born and raised in Hawaii face conflicting personal and social expectations due to factors including prejudicial attitudes about homosexuality, A/PIA racial/ethnic traditions, and the unique cultural milieu of Hawaii. Based on anecdotal and research reports of this Hawaii population, health and social needs are discussed with implications for professional health practice.

  13. JPRS Report, East Europe.

    DTIC Science & Technology

    2007-11-02

    European Confederation [Paris LE MONDE 15 Sep] 4 Jicinsky Comments on Concept of Federation [L1DOVE NOVINY 1 Sep] 5 Havel Ready To Oppose Resistance...Milieu Assessed [KAPU Sep] 21 POLAND POLITYKA Weekly News Roundup [POL1TYKA 25 Aug] 23 YUGOSLAVIA Croatian Democratic Party Chairman on...difficult problems should lead us to strengthen mutual ties and not to exhaust ourselves in unnecessary clashes." Havel Ready To Oppose Resistance to

  14. Walter Reed Army Institute of Research Annual Progress Report Fiscal Year 1983

    DTIC Science & Technology

    1983-10-01

    styles of the in- dividual and in part by the social milieu in which stressful events are experienced. This unit examines the interaction of the individual...physical and psychological stressors, including continuous performance and stressful social interaction . 24. (U) In both laboratory and field studies...Termination) 51 Li PAGE 111 Studies on the Interactions between Prostaglandins and Glucocorticoids to Improve Chemotherapeutic Measures for 1

  15. Prospective Evaluation of Intraprostatic Inflammation and Focal Atrophy as a Predictor of Risk of High-Grade Prostate Cancer and Recurrence after Prostatectomy

    DTIC Science & Technology

    2015-08-01

    Here we report on the exciting finding for mast cells, a component of the innate immune system . Final data included 462 men who recurred (cases) and 462...Prostate cancer, risk, incidence, recurrence, inflammation, focal atrophy, mast cells, immune cells, tissue microarray, biopsy, image analysis, odds...investigate the specific immune cell milieu of the prostate that may be associated with the development of an aggressive prostate cancer phenotype. These

  16. Imaging pain: a potent means for investigating pain mechanisms in patients

    PubMed Central

    Lee, M. C.; Tracey, I.

    2013-01-01

    Summary Chronic pain is a state of physical suffering strongly associated with feelings of anxiety, depression and despair. Disease pathophysiology, psychological state, and social milieu can influence chronic pain, but can be difficult to diagnose based solely on clinical presentation. Here, we review brain neuroimaging research that is shaping our understanding of pain mechanisms, and consider how such knowledge might lead to useful diagnostic tools for the management of persistent pain in individual patients. PMID:23794647

  17. Electron probe X-ray analysis of an intraocular foreign body.

    PubMed

    Chisholm, I A; Lalonde, J M; Ghadially, F N

    1977-10-01

    We describe a simple and rapid method of electron probe x-ray analysis on a foreign body removed from the eye. We demonstrated the presence of copper in an intraocular foreign body which has originated from a blank 0.22 calibre cartridge. Sodium, potassium, calcium, phosphorus, sulpher and chlorine were also detected. It seems likely that these elements were derived from the biological milieu in which the intraocular foreign body had rested for some 2 years and 9 months.

  18. Application and Interpretation of Bioassay and Biomonitoring: A Planning Document.

    DTIC Science & Technology

    1987-10-13

    food sources but may differ among floral food sources. Extrapolation from the earthworm bioassay should take into account that the lower molecular ... extraction protocols , the results of which remain an item of debate. Until the concomitant influences of developing biological activity are included in...rhizosphere consists of a physicochemical milieu which is whilly and completely apart from what can be measured or indexed from simple extractions made

  19. Promoting a healthy skepticism with regard to information processing

    SciTech Connect

    Stevens, D.F.

    1991-01-01

    Computer security professionals and members of collaborative research environments have conflicting objectives with respect to computer and network access, and different understandings of what constitutes a reasonable'' organization. These differences create tension between the two communities and make the achievement of an acceptable level of security a matter of some difficulty in such environments. We consider some of the differences and present the elements of a program aimed at promoting sensible computer and network security in the research milieu.

  20. BRMS1 Suppresses Breast Cancer Metastasis to Bone via Its Regulation of microRNA-125b and Downstream Attenuation of TNF-Alpha and HER2 Signaling Pathways

    DTIC Science & Technology

    2014-04-01

    cytoskeleton genes and genes regulating focal adhesion assembly, such as a5 integrin, Tenascin C, Talin-1, Profilin 1, and Actinin [35]. Intravital ...and allowed to adhere for time indicated, at which point cells were fixed and stainedwith crystal violet. Representative images for times 5, 10, 15...matrix milieu and imaged by time-lapse microscopy for 1 h or fixed and stained with crystal violet at times indicated. As shown in Figure 1C and

  1. [The significance of Ptolemy's Almagest for its early readers].

    PubMed

    Bernard, Alain

    2010-01-01

    The paper explores the historical reasons why Ptolemy's Almagest was cultivated in Antiquity as a legitimate part of ancient culture. It tries to elucidate first the precise nature of Ptolemy's project in the Almagest, its relation to ethics as well as to the particular conception that Ptolemy had of mathematics. It then proposes an explanation for the fact that this treatise, both in Ptolemy's period and afterwards, was studied within the milieu of ancient astrologers.

  2. Applied Demography: Its Current Scope and Future Direction in the United States

    DTIC Science & Technology

    1988-10-01

    store. Growth in one - stop shopping, direct marketing, and home-delivered food reflects these developments. Human Resource Planning U.S. companies now...distinguish it from a typical supermarket: a wider range of merchandise, a more spacious milieu, and a layout that reinforces one - stop shopping (the concept...behind this new type of store). Indeed, combination stores are targeted for the broad segment of consumers attracted by the convenience of one - stop shopping

  3. Letter to Freud: on the plight of psychoanalysis.

    PubMed

    Mendes, Dinah M

    2011-12-01

    In the form of a letter, the writer communicates to Freud her appreciation for the incomparable richness and complexity of the psychoanalytic enterprise in its century-long evolution from classical, Freudian origins to new developments in theory and technique. At the same time, concern is expressed about the continuity and survival of psychoanalysis in a cultural milieu that has absorbed its once radical ideas about sexuality and unconscious motivation while resisting its viability as a method of treatment.

  4. Swapnaushadhi: the embedded logic of dreams and medical innovation in Bengal.

    PubMed

    Mukharji, Projit Bihari

    2014-09-01

    Numerous medicines in South Asia have their origins in dreams. Deities, saints and other supernatural beings frequently appear in dreams to instruct dreamers about specific remedies, therapeutic techniques, modes of care etc. These therapies challenge available models of historicising dreams. Once we overcome these challenges and unearth the embedded logic of these dreams, we begin to discern in them a dynamic institution that enabled and sustained therapeutic change within a 'traditional' medical milieu.

  5. Medical Examination and Poor Relief in Early Modern Germany

    PubMed Central

    Hammond, Mitchell Lewis

    2011-01-01

    Summary This article investigates the role of the medical examination in municipal poor relief programmes between 1570 and 1620. Documents from the city of Nördlingen, a community of approximately 10,000 people in 1600, suggest that municipal facilities addressed a range of serious illnesses for a wide spectrum of the population. Practitioners were influenced by their Galenic medical milieu but ultimately focused on a range of practical resource questions rather than the diagnosis of an individual's disease.

  6. Abu al-Layth al-Libi

    DTIC Science & Technology

    2015-02-01

    Introduction In the tradition of post-9/11 senior Arab militant figures operating in Khurasan (the Afghanistan-Pakistan region), there is little doubt as to...the standing of Libyan jihadi commander Abu al-Layth al-Libi. If Usama bin Ladin and Ayman al-Zawahiri came to be the most prominent Arab -Afghan...Libi, a longtime leader of the Libyan Islamic Fighting Group (LIFG), who rapidly established himself as the champion of the Arab -Afghan milieu after

  7. Ian Curtis: Punk rock, epilepsy, and suicide.

    PubMed

    Tuft, Mia; Gjelsvik, Bergljot; Nakken, Karl O

    2015-11-01

    Ian Curtis was the front man of the post-punk band Joy Division. He suffered from epilepsy and actively incorporated his experiences of the disease in his lyrics. Curtis had frequent epileptic seizures, both on and off stage. After dying from suicide in 1980, he became a legend in the post-punk milieu. The impact which the epilepsy, the epilepsy treatment, and comorbid depression had on his artistic life and premature death is not well known.

  8. Evolution de la reanimation transfusionnelle du blesse hemorragique grave au sein des forces militaires americaines (Evolution of US Military Transfusion Support for Resuscitation of Trauma and Hemorrhagic Shock)

    DTIC Science & Technology

    2013-04-15

    propice aux avancées médicales. En milieu militaire, les capacités logistiques et l’organisation efficace permettent de rapidement diffuser de nouvelles...Prat N., Pidcoke H. F., Sailliol A., Cap A. P., 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND...ADDRESS(ES) United States Army Institute of Surgical Research, JBSA Fort Sam Houston, TX 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING

  9. Supporting the integration of technology into contemporary nursing education.

    PubMed

    Weiner, Elizabeth E

    2008-12-01

    This article provides an overview of the challenges and strategies faced by educational administrators in planning, delivering, and evaluating technology services to today's nursing students and faculty. Academic technology uses, examples, and support suggestions are provided so that educational administrators can effectively choose appropriate technologies geared to meet their educational objectives. The challenge comes with deciding the intended educational outcomes, and designing the appropriate educational milieu. Administrators are reminded to look to central administration to coordinate and participate in technology planning.

  10. Acceptability and impact of pet visitation on a pediatric cardiology inpatient unit.

    PubMed

    Wu, Adam S; Niedra, Ruta; Pendergast, Lisa; McCrindle, Brian W

    2002-10-01

    We evaluated the effectiveness of a pet visitation program in helping children and their families adjust to hospitalization on a pediatric cardiology ward. Thirty-one pet visits were observed and followed by interviews with patients and parents. Analysis of data suggested that pet visits relieved stress, normalized the hospital milieu, and improved patient and parent morale. The benefit received by the subjects correlated with the amount of physical contact and rapport developed with the visiting animal.

  11. Prior Exercise Alters Responses to Hemorrhage

    DTIC Science & Technology

    2010-07-01

    for the swine in our laboratory (4, 17). Plasma renin activ- ity (PRA), aldosterone, cortisol, and adrenocorticotropic hormone (ACTH) were measured...could aid in their care. Exercise acutely reduces blood volume, increases plasma lactate concentrations, and alters the hormonal /immunologic milieu...concentration was measured enzymatically with a commercial kit (Sigma Chemical Co, St Louis, Mo). Hormone concentrations were measured with tech- niques validated

  12. Étude et développement d'une source de pompage optique VUV de forte puissance pour l'amplification d'impulsions laser femtosecondes surlatransition XeF(C-A)

    NASA Astrophysics Data System (ADS)

    Tcheremiskine, V. I.; Sentis, M.; Mikheev, L. D.; Clady, R.

    2003-06-01

    Le rayonnement UV-VUV issu d'un plasma généré par une décharge électrique de forte puissance dans un milieu gazeux (ici XeF2) est capable d'exciter de grands volumes de différents milieux lasers. Nous présentons une nouvelle source optique UV-VUV de forte puissance basée sur une décharge multi-canaux réalisée sur la surface d'un diélectrique ainsi que les premiers résultats d'amplification d'impulsions femtosecondes obtenus dans le milieu actif d'un laser photolytique XeF(C-A). Ce milieu est très attractif pour développer des systèmes lasers hybrides de forte puissance (petawatt) dans le domaine du visible. En effet, la transition XeF(C-A) est caractérisée par une bande spectrale très large dans le bleu-vert (460-520 nm) permettant d'amplifier des impulsions optiques d'une durée de l'ordre de 10 fs.

  13. The route to pathologies in chronic inflammatory diseases characterized by T helper type 2 immune cells

    PubMed Central

    Jovanovic, K; Siebeck, M; Gropp, R

    2014-01-01

    T helper type 2 (Th2)-characterized inflammatory responses are highly dynamic processes initiated by epithelial cell damage resulting in remodelling of the tissue architecture to prevent further harm caused by a dysfunctional epithelial barrier or migrating parasites. This process is a temporal and spatial response which requires communication between immobile cells such as epithelial, endothelial, fibroblast and muscle cells and the highly mobile cells of the innate and adaptive immunity. It is further characterized by a high cellular plasticity that enables the cells to adapt to a specific inflammatory milieu. Incipiently, this milieu is shaped by cytokines released from epithelial cells, which stimulate Th2, innate lymphoid and invariant natural killer (NK) T cells to secrete Th2 cytokines and to activate dendritic cells which results in the further differentiation of Th2 cells. This milieu promotes wound-healing processes which are beneficial in parasitic infections or toxin exposure but account for increasingly dysfunctional vital organs, such as the lung in the case of asthma and the colon in ulcerative colitis. A better understanding of the dynamics underlying relapses and remissions might lead ultimately to improved therapeutics for chronic inflammatory diseases adapted to individual needs and to different phases of the inflammation. PMID:24981014

  14. Influence of pH on wound-healing: a new perspective for wound-therapy?

    PubMed

    Schneider, Lars Alexander; Korber, Andreas; Grabbe, Stephan; Dissemond, Joachim

    2007-02-01

    Wound healing is a complex regeneration process, which is characterised by intercalating degradation and re-assembly of connective tissue and epidermal layer. The pH value within the wound-milieu influences indirectly and directly all biochemical reactions taking place in this process of healing. Interestingly it is so far a neglected parameter for the overall outcome. For more than three decades the common assumption amongst physicians was that a low pH value, such as it is found on normal skin, is favourable for wound healing. However, investigations have shown that in fact some healing processes such as the take-rate of skin-grafts require an alkaline milieu. The matter is thus much more complicated than it was assumed. This review article summarises the existing literature dealing with the topic of pH value within the wound-milieu, its influence on wound healing and critically discusses the currently existing data in this field. The conclusion to be drawn at present is that the wound pH indeed proves to be a potent influential factor for the healing process and that different pH ranges are required for certain distinct phases of wound healing. Further systematic data needs to be collected for a better understanding of the pH requirements under specific circumstances. This is important as it will help to develop new pH targeted therapeutic strategies.

  15. Differentiation--a consequence of idiotype-environment interaction.

    PubMed

    Glock, H; Gregorius, H R

    1984-01-01

    The present paper deals with a model of idiotype-environment interaction and its application to a tissue culture experiment with birch (Betula pendula ROTH.). The data of the experiment are characterized with respect to the physiological reactions and are discussed in the light of the model. The main results of the paper are: With respect to the environmental action one has to discriminate between the environment inside and outside the cell (external and internal environment). The environmental influences cause a differential gene activity which lead to transient differentiation states and to final states of differentiatedness. During mitosis two types of information transmission take place: transmission of genetic material (the "blueprint") and transmission of the milieu (the "experience" of previous events). They together give rise to differentiation. The data of the experiment show that differentiation is no one-way street: Because of the transmitted milieu it is sometimes easier to regain an earlier differentiation state than to reach a new one. Only the interaction of idiotype (sum of genetic information) and the milieu state (internal environment) causes parallel as well as divergent development of cell lines. The model is also used to reinterpret some selected papers in the literature.

  16. Length of Stay and Achievement of Functional Milestones in a Rural First Nations Population in Northwestern Ontario during Acute-Care Admission after Total Hip Replacement: A Retrospective Chart Review.

    PubMed

    Sinclair, Cameal; Brunton, Nicole; Hopman, Wilma M; Kelly, Len

    2015-08-01

    Objet: Comprendre le parcours de soins de physiothérapie postopératoires de courte durée pour les membres des Premières Nations qui retournent dans des collectivités éloignées offrant des services de réadaptation limités après une arthroplastie totale de la hanche (ATH); évaluer la durée du séjour et l'atteinte des jalons fonctionnels à la suite d'une ATH afin de déterminer dans quelle mesure et avec quelle efficacité le cheminement clinique de patients des Premières Nations effectué en milieu urbain peut être transféré en milieu rural. Méthodes: Les données ont été recueillies de façon rétrospective en examinant les dossiers de patients qui ont subi une arthroplastie totale de la hanche dans la circonscription hospitalière du nord-ouest de l'Ontario entre 2007 et 2012. Constatations: Pour les 36 dossiers de patient examinés, la durée du séjour (DDS) médiane au centre de santé Meno Ya Win de Sioux Lookout était de 7,5 jours (étendue: de 2 à 335); la DDS médiane à compter du moment de l'intervention chirurgicale à l'hôpital régional (Centre régional des sciences de la santé de Thunder Bay) jusqu'au départ du centre de santé Meno Ya Win de Sioux Lookout était de 13,5 jours; et le temps médian de recouvrement de la capacité à marcher et à monter des escaliers était de 9 jours (étendue: de 1 à 93). Conclusion: Les cheminements cliniques en milieu urbain généralement reconnus ne conviennent pas aux petits hôpitaux ruraux à partir desquels les patients des Premières Nations retournent dans des collectivités éloignées qui n'offrent pas de services de réadaptation. La DDS dans un centre de soins actifs en milieu rural est semblable à la DDS dans un centre de réadaptation en milieu urbain.

  17. Holism and life manifestations: molecular and space-time biology.

    PubMed

    Krecek, J

    2010-01-01

    Appeals of philosophers to look for new concepts in sciences are being met with a weak response. Limited attention is paid to the relation between synthetic and analytic approach in solving problems of biology. An attempt is presented to open a discussion on a possible role of holism. The term "life manifestations" is used in accordance with phenomenology. Multicellular creatures maintain milieu intérieur to keep an aqueous milieu intracellulair in order to transform the energy of nutrients into the form utilizable for driving cellular life manifestations. Milieu intérieur enables to integrate this kind of manifestations into life manifestations of the whole multicellular creatures. The integration depends on a uniqueness and uniformity of the genome of cells, on their mutual recognition and adherence. The processes of ontogenetic development represent the natural mode of integration of cellular life manifestations. Functional systems of multicellular creatures are being established by organization of integrable cells using a wide range of developmental processes. Starting from the zygote division the new being displays all properties of a whole creature, although its life manifestations vary. Therefore, the whole organism is not only more than its parts, as supposed by holism, but also more than developmental stages of its life manifestations. Implicitly, the units of whole multicellular creature are rather molecular and developmental events than the cells per se. Holism, taking in mind the existence of molecular and space-time biology, could become a guide in looking for a new mode of the combination of analytical and synthetic reasoning in biology.

  18. Ca2+ regulatory mechanisms of exercise protection against coronary artery disease in metabolic syndrome and diabetes

    PubMed Central

    2011-01-01

    Chronic exercise attenuates coronary artery disease (CAD) in humans largely independent of reductions in risk factors; thus major protective mechanisms of exercise are directly within the coronary vasculature. Further, tight control of diabetes, e.g., blood glucose, can be detrimental. Accordingly, knowledge of mechanisms by which exercise attenuates diabetic CAD could catalyze development of molecular therapies. Exercise attenuates CAD (atherosclerosis) and restenosis in miniature swine models, which enable precise control of exercise parameters (intensity, duration, and frequency) and characterization of the metabolic syndrome (MetS) and diabetic milieu. Intracellular Ca2+ is a pivotal second messenger for coronary smooth muscle (CSM) excitation-contraction and excitation-transcription coupling that modulates CSM proliferation, migration, and calcification. CSM of diabetic dyslipidemic Yucatan swine have impaired Ca2+ extrusion via the plasmalemma Ca2+ ATPase (PMCA), downregulation of L-type voltage-gated Ca2+ channels (VGCC), increased Ca2+ sequestration by the sarcoplasmic reticulum (SR) Ca2+ ATPase (SERCA), increased nuclear Ca2+ localization, and greater activation of K channels by Ca2+ release from the SR. Endurance exercise training prevents Ca2+ transport changes with virtually no effect on the diabetic milieu (glucose, lipids). In MetS Ossabaw swine transient receptor potential canonical (TRPC) channels are upregulated and exercise training reverses expression and TRPC-mediated Ca2+ influx with almost no change in the MetS milieu. Overall, exercise effects on Ca2+ signaling modulate CSM phenotype. Future studies should 1) selectively target key Ca2+ transporters to determine definitively their causal role in atherosclerosis and 2) combine mechanistic studies with clinical outcomes, e.g., reduction of myocardial infarction. PMID:21596923

  19. The Effects of Hypoxia on U937 Cell Line in Mesenchymal Stem Cells Co-Culture System

    PubMed Central

    Ejtehadifar, Mostafa; Shamsasenjan, Karim; Akbarzadehlaleh, Parvin; Zahedi, Sarah; Kazemi, Narjes

    2016-01-01

    Purpose: Mesenchymal Stem Cells (MSCs) are the most important members of Bone Marrow (BM) milieu. MSCs affect different kinds of cells, particularly malignant cells of hematologic malignancies, but the effects of MSCs are unclear exactly. Here we analyzed the effects of derived Umbilical Cord Blood-MSCs on proliferation, cell death and some surface markers of U937 cell line in a Co-culture system with MSCs. Methods: Here we designed Co-culture systems as a model of BM milieu. We cultured U937 cells on UCB-MSCs and MSCs Conditioned Medium (C.M) driven and then treated U937 cells with optimum concentration of chloride cobalt (CoCl2) as a hypoxia-mimetic agent. In addition, we applied suitable concentrations of H2O2 to induce cell death. Proliferation rate, cell death rate and some surface markers of hypoxic U937 cells were analyzed by MTT assay, flow cytometry and Real Time-PCR were flown respectively. Results: UCB-MSCs showed supportive effects on U937 proliferation rate in normoxia and hypoxia. Lethal effect of H2O2 suppressed in the presence of UCB-MSCs in hypoxia and normoxia. Among CD11a, CD14, CD49d, CD54 and CD116 markers, CD49d was down regulated in presence of UCB-MSCs and CD116 was up regulated in hypoxia. Other markers didn’t show any significant changes. Conclusion: This work provides evidences that MSCs play critical roles in U937 cells biology. These observations shed new light on MSCs roles and demonstrated that MSCs should be regarded as an important member of BM milieu in several clinical applications such as BM transplantation prognosis and treatment of hematologic malignancies. PMID:28101472

  20. Self psychology conceptualization of postpsychotic depression and recovery among paranoid schizophrenic patients.

    PubMed

    Potik, David

    2014-01-01

    Many psychoanalysts have offered innovative ideas on the treatment of schizophrenic patients, but none on postpsychotic depression. The author presents a psychoanalytic conceptualization of postpsychotic depression based on Kohut's ideas regarding the development of normal and pathological grandiosity. The main premise is that postpsychotic depression stems from the loss of psychotic grandiosity, and that it is the psychological reaction to the loss of omnipotent identity whose role it is to provide an alternative reality. Through near-experience connectedness, clinicians and practitioners in the psychiatric rehabilitation field can facilitate an empathic milieu in which new mental constructs can be established and new behavioral skills can be learned.

  1. [Claude Bernard and the Comptes Rendus de la Société de Biologie: the movie of the physiological revolution by him who made it (1849-1878)].

    PubMed

    Hainaut, Jean

    2009-01-01

    Claude Bernard presented most of his fundamental results to the Société de Biologie, including proof of the modulation of the nervous system by the internal micromilieu. However, he did not describe the principle of a stable internal milieu as a condition for free life. Physiology, which is a part of biology, was not founded on cellular biology. Rather, Claude Bernard considered chemistry, anatomy and histology as the necessary auxiliary sciences for physiology. His articles are direct pictures, and not isolated ones, despite possible limitations, from a pre-montage movie of the physiological revolution he thought he had initiated, but not finished.

  2. Calcium Handling and Arrhythmogenesis.

    PubMed

    Bompotis, Georgios C; Pappas, Loukas K; Angelidis, Christos; Kossyvakis, Charalampos; Giannopoulos, Georgios; Deftereos, Spyridon

    2016-01-01

    Intracellular calcium homeostasis plays a fundamental role in the electric and mechanical function of the heart by modulating action potential pattern and duration, by linking cell membrane depolarization to myocardial contraction and by regulating cardiac automaticity. Abnormalities of intracellular calcium regulation disrupt the electrophysiological properties of the heart and create an arrhythmogenic milieu, which promotes atrial and ventricular arrhythmogenesis and impairs cardiac automaticity and atrioventricular conduction. In this brief review, we summarize the basic genetic, molecular and electrophysiological mechanisms linking inherited or acquired intracellular Ca(2+) dysregulation to arrhythmogenesis.

  3. Elemental diets in the prophylaxis and therapy for intestinal lesions: an update

    SciTech Connect

    Bounous, G.

    1989-05-01

    The recognition of potentially noxious physiologic substances in the intestinal milieu prompted the use of an elemental semihydrolyzed formula diet in the prophylaxis of experimental acute ischemic enteropathy. Elemental diets have been used in the management of a variety of digestive diseases. An elemental diet protects the intestinal mucosa of rodents from radiation injury and facilitates mucosal healing. Clinical trials have shown the benefits of this form of treatment in the prevention of acute radiation enteropathy and in the therapy for delayed radiation enteropathy and Crohn's disease.90 references.

  4. Scholarship and diversity in higher education.

    PubMed

    Akombo, David O

    2013-01-01

    Colleges and universities which are less diverse in their communities are often characterized by values, behavior patterns, and linguistic traits impinging on the institutions' milieu. These traits differ in significant ways from those within the dominant society for which the institution is established. The diverse students, and faculty alike, find these policies to be quasi-exclusive and limited to the geographical and demo- graphical environments in which the institutions are located. This paper examines some of these traits that affect the experience in higher education for both students and faculty from minority groups.

  5. [The medical world of Juan Gil de Zamora's Historia Naturalis (ca. 1275-1296)].

    PubMed

    García Ballester, L; Domínguez, A

    1994-01-01

    The article describes the authors and works which were quoted by the Franciscan Juan Gil de Zamora in his Historia naturalis, a scientific encyclopaedia written between c. 1275 and before 1296, probably in the Franciscan monastery of Zamora (Kingdom of Castille). Juan Gil made wide use of the Avicenna's Canon, Gilbertus de Aquila (Anglicus)'s Compendium medicine, and Salernitan medical literature. His work contributed to the diffusion of these medical authors and works throughout the Christian intellectual milieu of late medieval Castille. This diffusion was not without problems.

  6. The influence of managed care on U.S. baccalaureate nursing education programs.

    PubMed

    Jackson, Susan E

    2006-02-01

    The transformation of health care into managed care has raised many issues and concerns for nurse educators. The milieu in which nurses currently practice reflects the restructuring shaped by managed care principles. The shift from acute care to expanded community services has changed the way health care is provided within hospital settings. The organization of nursing programs has been affected by this shift, and the ramifications of these external forces on curriculum structure have altered the way nursing students are educated. This article presents research demonstrating the changes in the structure of the curricula for baccalaureate nursing education in 2001, which were caused by health care reform in effect since 1994.

  7. Measurement of Toxic industrial Chemicals, Chemical Warfare Agents and Their Simulants: A LWIR Passive Standoff Detection Study

    DTIC Science & Technology

    2007-04-01

    obscurcissants n’affectent pas de façon significative les capacités de détection des capteurs passifs en retrait. Les résultats obtenus avec le GB en milieu...ainsi que de gaz chimiques toxiques tels que le phosgène et le GB. Résultats Ce rapport décrit la détection, à l’aide de CATSI (Compact...obscurcissants n’affectaient pas de façon significative les capacités des capteurs passifs en retrait. Les résultats obtenus avec le GB à ciel ouvert ont

  8. Apoptosis, Necrosis, and Necroptosis in the Gut and Intestinal Homeostasis

    PubMed Central

    Negroni, Anna; Cucchiara, Salvatore; Stronati, Laura

    2015-01-01

    Intestinal epithelial cells (IECs) form a physiochemical barrier that separates the intestinal lumen from the host's internal milieu and is critical for electrolyte passage, nutrient absorption, and interaction with commensal microbiota. Moreover, IECs are strongly involved in the intestinal mucosal inflammatory response as well as in mucosal innate and adaptive immune responses. Cell death in the intestinal barrier is finely controlled, since alterations may lead to severe disorders, including inflammatory diseases. The emerging picture indicates that intestinal epithelial cell death is strictly related to the maintenance of tissue homeostasis. This review is focused on previous reports on different forms of cell death in intestinal epithelium. PMID:26483605

  9. Apoptosis, Necrosis, and Necroptosis in the Gut and Intestinal Homeostasis.

    PubMed

    Negroni, Anna; Cucchiara, Salvatore; Stronati, Laura

    2015-01-01

    Intestinal epithelial cells (IECs) form a physiochemical barrier that separates the intestinal lumen from the host's internal milieu and is critical for electrolyte passage, nutrient absorption, and interaction with commensal microbiota. Moreover, IECs are strongly involved in the intestinal mucosal inflammatory response as well as in mucosal innate and adaptive immune responses. Cell death in the intestinal barrier is finely controlled, since alterations may lead to severe disorders, including inflammatory diseases. The emerging picture indicates that intestinal epithelial cell death is strictly related to the maintenance of tissue homeostasis. This review is focused on previous reports on different forms of cell death in intestinal epithelium.

  10. The Other End of the Rainbow: Infrared and Skin

    PubMed Central

    Holzer, Aton M.; Elmets, Craig A.

    2010-01-01

    Summary Although infrared radiation is ubiquitous in the terrestrial milieu, the effects of infrared radiation on human skin have traditionally been ignored. Recent studies suggest an important role for infrared A radiation (760–1440 nm) in dermal inflammation, photoaging and photocarcinogenesis. In this issue, Calles et al. identify and analyze the IRA-induced transcriptome in human dermal fibroblasts. Their work paves the way for new research directions in IRA photobiology, and raises important clinical questions regarding photoprotection and IR-based dermatotherapy. PMID:20463675

  11. Cleavage of transmembrane junction proteins and their role in regulating epithelial homeostasis

    PubMed Central

    Nava, Porfirio; Kamekura, Ryuta; Nusrat, Asma

    2013-01-01

    Epithelial tissues form a selective barrier that separates the external environment from the internal tissue milieu. Single epithelial cells are densely packed and associate via distinct intercellular junctions. Intercellular junction proteins not only control barrier properties of the epithelium but also play an important role in regulating epithelial homeostasis that encompasses cell proliferation, migration, differentiation and regulated shedding. Recent studies have revealed that several proteases target epithelial junction proteins during physiological maturation as well as in pathologic states such as inflammation and cancer. This review discusses mechanisms and biological consequences of transmembrane junction protein cleavage. The influence of junction protein cleavage products on pathogenesis of inflammation and cancer is discussed. PMID:24665393

  12. Residential hospice environments: evidence-based architectural and landscape design considerations.

    PubMed

    Verderber, Stephen

    2014-01-01

    The residential hospice care movement is increasingly accepted and supported globally, and yet, unfortunately, the amount of literature on best practices in the planning and design of residential hospice facilities and adjacent outdoor spaces remains relatively small. This paper reports on a compendium of architectural and landscape design considerations that reflect the fundamental dimensions of the residential hospice experience: site and context, arrival spaces, communal and private spaces of the residential milieu, transitional spaces, and nature connectivity. Additionally, key staffing and administrative ramifications of this built-environment compendium are addressed, as are prognostications and challenges for the future.

  13. Pathophysiology of Coronary Thrombus Formation and Adverse Consequences of Thrombus During PCI

    PubMed Central

    Srikanth, Sundararajan; Ambrose, John A

    2012-01-01

    Atherosclerosis is a systemic vascular pathology that is preceded by endothelial dysfunction. Vascular inflammation “fuels” atherosclerosis and creates the milieu for episodes of intravascular thromboses. Thrombotic events in the coronary vasculature may lead to asymptomatic progression of atherosclerosis or could manifest as acute coronary syndromes or even sudden cardiac death. Thrombus encountered in the setting of acute coronary syndromes has been correlated with acute complications during percutaneous coronary interventions such as no-reflow, acute coronary occlusion and long term complications such as stent thrombus. This article reviews the pathophysiology of coronary thrombogenesis and explores the complications associated with thrombus during coronary interventions. PMID:22920487

  14. The Future Is Now: Software-Guided Intensive Insulin Therapy in the Critically Ill

    PubMed Central

    Rattan, Rishi; Nasraway, Stanley A.

    2013-01-01

    Since the development of intensive insulin therapy for the critically ill adult, tight glycemic control (TGC) has become increasingly complicated to apply and achieve. Software-guided (SG) algorithms for insulin dosing represent a new method to achieve euglycemia in critical illness. We provide an overview of the state of SG TGC with an eye to the future. The current milieu is disorganized, with little research that incorporates newer variables of dysglycemia, such as glycemic variability. To develop and implement better algorithms, scientists, programmers, and clinicians need to standardize measurements and variables. PMID:23567013

  15. Stopping the culture of workplace incivility in nursing.

    PubMed

    Khadjehturian, Rachele E

    2012-12-01

    Workplace incivility (WI) continues to hamper professional nursing practice, patient care, and the health of nurses who encounter this phenomenon in their workplace. This article provides an exemplar of WI experienced by a new nurse when a more seasoned nurse uses humiliation, intimidation, and angry verbal abuse to accuse the novice nurse in the presence of coworkers and patients that she failed to provide essential nursing care to a challenging patient. Nurses are reminded that open communication among coworkers will help minimize the occurrence of WI, encourage a supportive milieu in the unit, and ensure the safety of patients, family, and staff.

  16. Changes in food habits of south Indian Hindu Brahmin immigrants in State College, PA.

    PubMed

    Mahadevan, Meena; Blair, Dorothy

    2009-01-01

    This study was conducted to understand the factors influencing changes in the food habits of south Indian Brahmin immigrants in State College, PA. Data was collected from participants (n = 28) using a semi-structured interview based on the PRECEDE framework, and participant observations. Analysis of the data used grounded theory generated themes highlighting their food acculturation experience. Adjusting in State College was described as a "delicate balance" that meant maintaining their south Indian traditions while at the same time adapting to the cultural milieu of a town that favored north Indian cuisine, and "blending in" with the larger American society.

  17. Physiopathologie et Pathologie des Affections du Rachis en Medecine Aerospatiale (Physiopathology and Pathology of Affections of the Spine in Aerospace Medicine),

    DTIC Science & Technology

    1981-04-01

    partant du principe que le nucleus eat un capteur de force. Ils ont 6tabli que la pression du milieu liquide A 1’int~rieur du nucl6us 6tait directement li~e...si is tampa de isont~e en acc6l~ration eat court par rapport aux p~riodes naturelles dti corps ( jolt 6lev6) on pourra assistar & des ph~nomtns d...phiques et des cadavres 6quip6s d’acc6ldrombtres, de jauges de contrainte et de capteurs d’ef fort, ii a 6t6 possible de tirer un certain nombre de

  18. Kurt Gödels Brünner Verwandte

    NASA Astrophysics Data System (ADS)

    Müller, Dora

    2007-11-01

    The author of this memoir Dora Müller (born 1920) belongs - as well as Kurt Gödel-to the German minority playing an important role in the past life of Brno. The marriage of his son included her among the Gödels collaterals. She was chemist, but also pianist, historician, participant of antinacist movement and iniciator of Czech-German understanding after war. Following her personal experiences, remembrances of Gödels relatives and documental materials, she evokes the atmosphere of broader family milieu of Kurt Gödel.

  19. NANOPARTICLES AND THEIR APPLICATIONS IN CELL AND MOLECULAR BIOLOGY

    PubMed Central

    Wang, Edina C.; Wang, Andrew Z.

    2013-01-01

    Nanoparticles can be engineered with distinctive compositions, sizes, shapes, and surface chemistries to enable novel techniques in a wide range of biological applications. The unique properties of nanoparticles and their behavior in biological milieu also enable exciting and integrative approaches to studying fundamental biological questions. This review will provide an overview of various types of nanoparticles and concepts of targeting nanoparticles. We will also discuss the advantages and recent applications of using nanoparticles as tools for drug delivery, imaging, sensing, and for the understanding of basic biological processes. PMID:24104563

  20. A further footnote to Freud's "fragment of an analysis of a case of hysteria".

    PubMed

    Rogow, A A

    1978-01-01

    While ther is no evidence that Freud ever had in analysis a leading political figure, he did analyze the sister of one, and made her the basis of an important case study. Dora's brother, Otto Bauer, was an influential Marxist theoretician and leader of the Austrian Socialist Party from 1918 to 1934. Freud's Dora case illuminates the psychodynamics of Otto Bauer's life and career, and a re-examination of the case together with recent research also provides us with new information about Freud's analysis of Dora and the milieu in which they both lived.