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Sample records for milieu acetique tamponne

  1. The therapeutic milieu: changing themes and theories.

    PubMed

    Gutheil, T G

    1985-12-01

    Since its development close to 40 years ago in England, the therapeutic milieu, or therapeutic community, has undergone significant alteration and corruption by the emphasis on community care, increased use of pharmacotherapy, quick staff turnover, and lack of psychoanalytically trained staff. The hallmarks of milieu therapy, however, such as patients' participation in decision-making, collective responsibility for ward events, a multidisciplinary staff, and a belief in the rehabilitative potential of the environment, remain a part of many modern inpatient settings. The author believes that milieu therapy remains a viable treatment modality, and he offers guidelines for optimizing its potential.

  2. Milieu Teaching. What Works Clearinghouse Intervention Report

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2012

    2012-01-01

    "Milieu teaching" is a practice that involves manipulating or arranging stimuli in a preschool child's natural environment to create a setting that encourages them to engage in a targeted behavior. For example, a teacher might place a desirable toy in a setting to encourage a student to request that toy (where requesting a toy is the desired…

  3. Using the Milieu: Treatment-Environment Consistency.

    ERIC Educational Resources Information Center

    Szekais, Barbara

    1985-01-01

    Describes trial use of milieu and activity-based therapy in two adult day centers to increase client involvement in physical and social environments of treatment settings. Reports results from empirical observations and recommends further investigation of this treatment modality in settings for the elderly. (Author/NRB)

  4. Relaxation Assessment with Varied Structured Milieu (RELAX).

    ERIC Educational Resources Information Center

    Cassel, Russell N.; Cassel, Susie L.

    1983-01-01

    Describes Relaxation Assessment with Varied Structured Milieu (RELAX), a clinical program designed to assess the degree to which an individual is able to demonstrate self-control for overall general relaxation. The program is designed for use with the Cassel Biosensors biofeedback equipment. (JAC)

  5. The unique endocrine milieu of the fetus.

    PubMed Central

    Fisher, D A

    1986-01-01

    Table II summarizes in tabular form the major features of the fetal endocrine milieu discussed in the foregoing pages. The mammalian fetus develops in an environment where respiration, alimentation, and excretory functions are provided by the placenta. Fetal tissue metabolism is oriented largely to anabolism; body temperature is modulated by maternal metabolism, and fetal tissue thermogenesis is maintained at a basal level. Tissue and organ growth appear to be regulated by growth factors which probably function by autocrine or paracrine mechanisms during most of gestation (72, 146-148). In this milieu conventional endocrine control systems are largely redundant, and other transient systems more appropriate to the intrauterine environment have evolved. We have developed some insights into these systems, but much more information is necessary before we can truly understand this fascinating environment. PMID:3018041

  6. Social Allostasis: Anticipatory Regulation of the Internal Milieu

    PubMed Central

    Schulkin, Jay

    2010-01-01

    Social regulation of the internal milieu is a fundamental behavioral adaptation. Cephalic capability is reflected by anticipatory behaviors to serve systemic physiological regulation. Homeostatic regulation, a dominant perspective, reflects reactive responses; allostatic regulation, the physiology of change, emphasizes longer-term anticipatory, and feedforward systems. Steroids, such as cortisol, and peptides such as corticotrophin releasing hormone are but one example of such anticipatory regulatory systems. The concept of “allostasis” is in part to take account of anticipatory control amidst diverse forms of adaptation underlying this regulatory adaptation that supports social contact and the internal milieu. PMID:21369352

  7. Adolescent Health Promotion Groups: A Primer for Milieu Therapists

    ERIC Educational Resources Information Center

    Puskar, Kathryn; Bernardo, Lisa Marie; Stark, Kirsti Hetager; Frazier, Leann

    2008-01-01

    Adolescents who are required to live away from their families of origin face many challenges that can affect mood and mental health. Milieu therapists (mental health associates) working with adolescents in a residential treatment center may be expected to provide group activities that promote mental health. It is important for new group leaders to…

  8. Bioenergetics and Diffusion in the Crowded Milieu of Living Cells

    NASA Astrophysics Data System (ADS)

    Heikal, Ahmed

    2014-06-01

    Intracellular nicotinamide adenine dinucleotide (NADH) is a key cofactor in energy metabolism pathways and a myriad of oxidation-reduction reactions in living cells. The crowded milieu of these cells with organelles and macromolecules influences many biological processes such as biomolecular diffusion, protein-protein and protein-substrate interactions, and protein folding. In this contribution, I will highlight our recent findings on the role of macromolecular crowding on biochemical reaction between NADH and selected dehydrogenases in both living cells and in controlled macromolecules-rich environment. In addition, multiscale diffusion (rotational and translational) of a small fluorophore will be used to understand the role of non-specific binding, heterogeneity in microenvironmental viscosity in crowded solutions. Our experimental approach is a combination of fluorescence lifetime imaging microscopy, time-resolved anisotropy and fluorescence correlation spectroscopy. The broader impacts of these results will be discussed within the context of energy metabolism and biophysics in the crowded milieu of living cells.

  9. Experimental uremia affects hypothalamic amino acid neurotransmitter milieu.

    PubMed

    Schaefer, F; Vogel, M; Kerkhoff, G; Woitzik, J; Daschner, M; Mehls, O

    2001-06-01

    Chronic renal failure is associated with delayed puberty and hypogonadism. To investigate the mechanisms subserving the reported reduced pulsatile release of gonadotropin-releasing hormone (GnRH) in chronic renal failure, this study examined the amino acid neurotransmitter milieu in the medial preoptic area (MPOA), the hypothalamic region where the GnRH-secreting neurons reside, in 5/6-nephrectomized male rats and in ad libitum-fed or pair-fed controls. All rats were castrated and received either a testosterone or a vehicle implant to evaluate additional effects of the prevailing sex steroid milieu. Local excitatory (essential amino acids: aspartate, glutamate) and inhibitory (gamma-aminobutyric acid [GABA], taurine) amino acid transmitter outflow in the MPOA was measured by microdialysis via stereotactically implanted cannulae in the awake, freely moving rats. In addition to basal extracellular concentrations, the neurosecretory capacity was assessed by the addition of 100 mM KCl to the dialysis fluid. The mechanisms of neurosecretion were evaluated further by inhibition of vesicular release with the use of Ca(2+)-free, Mg(2+)-enriched dialysis fluid and by local perfusion with inhibitors of voltage-dependent synaptic release (1 microM tetrodotoxin) and of GABA reuptake (0.5 mM nipecotic acid). In the uremic rats, basal outflow of GABA, glutamate and aspartate, and K(+)-stimulated aspartate outflow were increased. K(+)-stimulated GABA and glutamate release was less sensitive to Ca(2+) depletion in the uremic than in the control rats. The elevated basal GABA and essential amino acid outflow in the uremic rats was due to a voltage- and Ca(2+)-independent mechanism. GABA reuptake was inhibited proportionately by nipecotic acid in uremic and pair-fed control rats. Testosterone supplementation had no independent effects on neurotransmitter outflow. In summary, the amino acid neurotransmitter milieu is altered in the MPOA of uremic rats by a nonsynaptic, nonvesicular

  10. Using Milieu Training to Promote Photograph Exchange for a Young Child with Autism

    ERIC Educational Resources Information Center

    Ogletree, Billy T.; Davis, Patricia; Hambrecht, Georgia; Phillips, Ellen Wooten

    2012-01-01

    A milieu teaching sequence was used to train photograph exchange as a method of requesting to a 7-year-old boy with autism. A multiple baseline design across four items (ball, puzzle, books, bubbles) was used to identify a functional relation between requesting and the milieu teaching sequence. Although performance during intervention was…

  11. Psychodynamic Milieu-Therapy and Changes in Personality--What Is the Connection?

    ERIC Educational Resources Information Center

    Heede, Tine; Runge, Hanne; Storebo, Ole Jakob; Rowley, Eva; Hansen, Kim Gabriel

    2009-01-01

    This article refers to the results of a prospective effect evaluation study of three psychodynamic milieu-therapeutic institutions for children, which included cognitive and projective testing. After introducing milieu-therapy and explaining its roots in psychoanalytic and developmental thinking, the specific results of the research evaluation are…

  12. Thrombosis in the uremic milieu--emerging role of "thrombolome".

    PubMed

    Shashar, Moshe; Francis, Jean; Chitalia, Vipul

    2015-01-01

    Chronic kidney disease (CKD) is characterized by retention of a number of toxins, which unleash cellular damage. CKD environment with these toxins and a host of metabolic abnormalities (collectively termed as uremic milieu) is highly thrombogenic. CKD represents a strong and independent risk factor for both spontaneous venous and arterial (postvascular injury) thrombosis. Emerging evidence points to a previously unrecognized role of some of the prothrombotic uremic toxins. Here, we provide an overview of thrombosis in CKD and an update on indolic uremic toxins, which robustly increase tissue factor, a potent procoagulant, in several vascular cell types enhancing thrombosis. This panel of uremic toxins, which we term "thrombolome" (thrombosis and metabolome), represents a novel risk factor for thrombosis and can be further explored as biomarker for postvascular interventional thrombosis in patients with CKD.

  13. The linguistic milieu of Norwegian children with hearing loss.

    PubMed

    Arnesen, Knut; Enerstvedt, Regi T; Engen, Elizabeth A; Engen, Trygg; Høie, Grete; Vonen, Arnfinn M

    2008-01-01

    The article is based on a national survey in Norway of the linguistic situation of deaf children. Parents, teachers, and children were asked to make judgments on topics related to the children's language milieu at home and at school by means of detailed questions using two response methods: a language inventory and rating scales. The inventory is more detailed than those in other studies and required all three groups to consider not only the use of the two native languages, Norwegian and Norwegian Sign Language, but other forms combining sign and speech. The data revealed that languages used with the children included both native languages as well as various mixtures depending on context, situation, and the nature and purpose of the communication. The results are considered from the perspective of the amount and quality of language input and intake necessary for language acquisition and literacy. PMID:18619070

  14. The science of healthy aging: genes, milieu, and chance.

    PubMed

    Rattan, Suresh I S

    2007-10-01

    Healthy aging and longevity depend on successful and dynamic interactions among biological, psychological, and environmental factors. Biological aging occurs mainly during the period of survival beyond the evolutionarily required essential lifespan (ELS). Natural selection processes for survival and successful reproduction have selected for a range of genetically determined ELS-assuring maintenance and repair systems (MRSs). The progressive failure of MRSs, and the consequent accumulation of molecular heterogeneity and damage, underlie the biological basis of aging, age-related diseases, and eventual death. However, the genetic processes of MRSs operate in a complex hierarchy of factors which range from intracellular molecular factors to physiological, psychological, environmental, and other stochastic factors, including chance. This view also facilitates setting up a framework for understanding, researching, and developing effective and realistic strategies for aging intervention, prevention, and therapies. Manipulating genes and the milieu in which genes and gene products operate opens up novel possibilities of aging intervention and prevention. Gene therapy, stem cells, and modulation through functional foods, nutriceuticals, cosmeceuticals and lifestyle alterations, including mild stress-induced hormesis, are examples of such strategies at various levels of development and practice.

  15. Les astronomes de l'Empire du Milieu

    NASA Astrophysics Data System (ADS)

    Bonnet-Bidaud, J. M.

    2007-02-01

    Explosions d'étoiles, comètes, durée du jour, taches solaires, dans tous ces domaines, des observations chinoises datant de plusieurs siècles sont encore utilisées aujourd'hui. Pendant plus de 4000 ans, les astronomes de l'Empire du Milieu, organisés dans les grands observatoires impériaux, ont noté jour après jour, mois après mois, avec la plus grande précision tous les phénomènes célestes. Et ce sont des milliers de textes couvrant des périodes depuis au moins le Ve siècle avant l'ère moderne jusqu'à fin de la dernière dynastie des Qing en 1911, qui ont été conservés et dont une grande partie n'a pu encore être véritablement étudiée. Un véritable trésor, malheureusement très mal connu en Europe et, de façon incompréhensible, largement ignoré par l'histoire moderne des sciences.

  16. [Epidemiology of obesity in the work milieu, Douala, Cameroon].

    PubMed

    Fouda, A A Bita; Lemogoum, D; Manga, J Owona; Il Dissongo, J; Tobbit, R; Moyo, D F Ngounou; Sume, G Etapelong; Kollo, B

    2012-01-01

    Obesity is a worldwide public health problem, and its burden has been poorly explored in Cameroon, especially in work place. We therefore carried out in April 2010, an analytic cross-sectional study aiming to determine the prevalence of obesity, associated risk factors and health risk in six randomly selected enterprises based in Douala. Among the 552 participants, 383 (69.4%) were males. Most of the workers (55.4%) were aged less than 35 years old. There was 191 (34.60%) office staff as against 361 (65.40%) labourers. In each participant, blood pressures, and fasting blood glucose were recorded, as well as obesity indexes comprising body mass index and waist circumference. They were calculated and data analyzed using SPSS 16 and Win Pepi 11.8. The prevalence of obesity in workers was 23.4%, and was more pronounced in women than in men (36.1% vs 17.8%; P < 0.005). The workers aged > or = 45 years old exhibited highest obesity rate than other age group (P = 0.03). Importantly, the prevalence of hypertension was two fold greater in obese workers than non obese (P < 0.005; RR = 2.1; IC 95%: 1.57-2.83). 271 (49.1%) of the workers were overweight. Among the obese subjects, those with visceral obesity: 56 (43.4%) females with a waist circumference > 88 cm and 41 (31.8%) men with a waist circumference > 102 cm were at very high health risk. Obesity was significantly associated with excessive alcohol consumption (P = 0.013) and high salt diet (P = 0.022). This study reveals a high burden of obesity in the work place in Douala and outlines the urgent needs of implementation of prevention programme in that milieu. PMID:22891584

  17. Cr stable isotope fractionation and reaction kinetics in aqueous milieu

    NASA Astrophysics Data System (ADS)

    Zink, S.; Schoenberg, R.; Staubwasser, M.

    2009-12-01

    Mass-dependent stable Cr isotope variations show great potential to monitor the natural attenuation of anthropogenic chromate pollution as well as to investigate changes in environmental conditions in the present and the past. However, accurate interpretation of mass-dependent Cr isotope variations requires profound knowledge of the Cr isotope fractionation behaviour during redox transitions and the isotope exchange kinetics of the reactions involved. Here, we present a comprehensive dataset of stable Cr isotope fractionation and reaction kinetics during Cr(III) oxidation, Cr(VI) reduction and isotopic exchange between soluble Cr(III) and Cr(VI) in aqueous milieu. All experiments were carried out with both oxidation states (i.e. Cr(III) and Cr(VI)) in solution, using H2O2 as oxidising as well as reducing agent. The pH conditions were varied to investigate the influence of the different Cr(III) and Cr(VI) species on the Cr isotope fractionation and on the reaction mechanisms during the enforced redox transitions. All Cr stable isotope measurements were performed by high-resolution MC-ICP-MS [1]. The reduction of Cr(VI) to Cr(III) with H2O2 under strongly acidic conditions shows an equilibrium isotope fractionation of Δ(53,52Cr)Cr(III)-Cr(VI) of -3.54 ± 0.35 ‰. This value is within uncertainty equal to that of -3.4 ± 0.1 ‰ reported by Ellis et al. [2], who used natural sediment and magnetite as reducing agents at pH 6 to 7. At pH = 7 our reduction experiments show a unidirectional, kinetic isotope fractionation Δ(53,52Cr)Cr(III)-Cr(VI) of approximately -5 ‰ for reduction rates of up to 80 %, but a strong deviation from this Rayleigh-type process for higher reduction rates. However, at a pH value of 7 H2O2 supports the temporary formation and decomposition of Cr(V)-peroxo complexes that might explain this fractionation behaviour and deviation from a single Rayleigh type trend. The oxidation experiments of Cr(III) to Cr(VI) were carried out in alkaline media

  18. Development of a Milieu Intervention Program for Treatment of Emotionally Disturbed Deaf Children.

    ERIC Educational Resources Information Center

    Edelstein, Terry

    Described is a milieu intervention scheme for treatment of disturbed deaf children (6-18 years old) in a residential school for the deaf. It is noted that the program sought to develop respect and awareness of the self and social group within the security of a specially adapted environment and to support reintegration into the social, academic,…

  19. Development of a Milieu Intervention Program for Treatment of Emotionally Disturbed Deaf Children.

    ERIC Educational Resources Information Center

    Edelstein, Terry

    Described is a milieu intervention scheme for treatment of disturbed deaf children (6 to 18 years old) in a residential school for the deaf. It is noted that the program sought to develop respect and awareness of the self and social group within the security of a specifically adapted environment and to support reintegration into the social,…

  20. Dragons and Dinosaurs: Directing Inquiry in Biology Using the Notions of "Milieu" and "Validation"

    ERIC Educational Resources Information Center

    Achiam, Marianne; Solberg, Jan; Evans, Robert

    2013-01-01

    This article describes how inquiry teaching can be directed towards specific content learning goals while allowing for student exploration and validation of hypotheses. Drawing from the Theory of Didactical Situations, the concepts of "milieu" and "validation" are illustrated through two sample biology lessons designed to engage and challenge…

  1. Describing Treatment Intensity in Milieu Teaching Interventions for Children with Developmental Disabilities: A Review

    ERIC Educational Resources Information Center

    Parker-McGowan, Quannah; Chen, Mo; Reichle, Joe; Pandit, Shivani; Johnson, LeAnne; Kreibich, Shelley

    2014-01-01

    Purpose: This investigation aimed to apply the dosage framework proposed by Warren, Fey, and Yoder (2007) to variations of milieu language teaching intervention strategies to explore how each of the dosage parameters (i.e., dose, dose form, dose frequency, total duration, and cumulative intervention intensity) was reported in the located…

  2. Impact of Milieu Teaching on Communication Skills of Young Children with Autism Spectrum Disorder

    ERIC Educational Resources Information Center

    Christensen-Sandfort, Robyn J.; Whinnery, Stacie B.

    2013-01-01

    This 5-month study examined the impact of a behaviorally based naturalistic teaching strategy, milieu teaching, on the communication skills of preschool-aged children with Autism Spectrum Disorder (ASD) in an early childhood special education (ECSE) classroom. A multiple baseline across participants design was used. Communication targets were…

  3. Melange a Quatre Ondes Degenere dans les Absorbants Saturables EN Milieu Mince

    NASA Astrophysics Data System (ADS)

    O'Neill, Claire

    1995-01-01

    Le melange a quatre ondes est utilise notamment pour determiner la duree des temps de reorientation moleculaire et mesurer la grandeur des susceptibilites nonlineaires du troisieme ordre. Nous avons mis en evidence les particularites du melange a quatre ondes degenere en milieu absorbant mince a l'aide du formalisme de l'optique nonlineaire et de l'approche holographique. Des experiences realisees avec des impulsions de 33 ps ont permis de caracteriser la cinetique de la nonlinearite en regime transitoire des molecules de rhodamine 6G incorporees dans des matrices d'alcool polyvinylique; un milieu aussi compose d'absorbants anisotropes, les molecules de rhodamine 6G en solution aqueuse et un autre forme d'absorbants isotropes, les films minces de cristaux de semiconducteur CdS_ {x}Se_{1-x} ont ete etudies. Nous avons observe pour ces trois milieux les signaux generes aux ordres superieurs par melange a quatre ondes degenere en milieu mince pour differentes conditions de polarisation.

  4. Feeling “overloaded” and “shortcomings”: milieu therapists’ experiences of vulnerability in caring for severely mentally ill patients

    PubMed Central

    Bachmann, Liv; Michaelsen, Ragnhild A; Vatne, Solfrid

    2016-01-01

    Background Milieu therapists’ relationships with patients with severe mental illnesses are viewed as challenging. Elucidating vulnerability from their perspective in daily face-to-face encounters with patients might contribute to extending our knowledge about milieu therapists’ vulnerability and the dynamics of the interaction between patients in mental health services and expertise in building caring and therapeutic relationships. The aim of this project was to study educated milieu therapists’ experiences of their own vulnerability in their interactions with patients in mental health services. Materials and methods The data collection method was focus-group interviews. Thirteen part-time master’s in mental health students (eight nurses, three social workers, two social educators) participated. All participants had experience with community or specialized mental health services (2–8 years). Results The milieu therapists mainly related their experiences of vulnerability to negative feelings elicited by challenging work conditions, disclosed as two main themes: 1) “overloaded”, by the possibility of being physically and mentally hurt and the burdens of long-lasting close relationships; milieu therapists were extremely vulnerable because of their difficulty in protecting themselves; and 2) “shortcomings”, connected to feelings of despair associated with not acting in concordance with their professional standards and insecurity about their skills to handle challenging situations, which was a threat to their professional integrity. There seemed to be coherence between vulnerability and professional inauthenticity. A misunderstanding that professionalism refers to altruism seems to increase milieu therapist vulnerability. Conclusion Vulnerability in health care is of interest to multiple disciplines, and is of relevance for knowledge development in higher education. Extended knowledge and understanding about milieu therapists’ vulnerability might

  5. Simvastatin Protects Osteoblasts from the Deleterious Effects of the Liquid Milieu of Multiple Myeloma

    PubMed Central

    Jitumori, R; Fernandes, D; Jitumori, C; Favero, GM

    2015-01-01

    ABSTRACT Lytic bone lesions are the main clinical manifestation of multiple myeloma. The intense variety in this cell microenvironment, composed mainly of fibroblasts, osteoblasts, osteoclasts, immune cells and mesenchymal cells, is influenced by the massive presence of neoplastic plasma cells. Studies with statins have reported their action in stimulating the formation and reducing bone resorption. The aim of this study was to verify the in vitro response of human osteoblasts exposed to the supernatant (liquid milieu) of multiple myeloma. The data obtained indicate that simvastatin has positive effects on the growth of osteoblasts and protection against the anti-proliferative effects of multiple myeloma supernatant. PMID:26426180

  6. Music: a milieu factor with implications for the nurse-therapist.

    PubMed

    Hinds, P S

    1980-06-01

    The effects of one type of music upon the social interactions observed in a group play therapy with ten male children, ages 8 to 10, were studied. A behavioral check list was developed to measure five target behaviors: the children's verbalizations, proximity with group members, proximity with the group co-therapists, involvement in toy exchanges and involvement in acts of physical aggression. The resulting statistical analysis of tabulated data suggests music to be a factor in an increased number of social interactions. Consideration of such a milieu factor as music may prove valuable in many varying situations. PMID:6249919

  7. Social Milieu Oriented Routing: A New Dimension to Enhance Network Security in WSNs.

    PubMed

    Liu, Lianggui; Chen, Li; Jia, Huiling

    2016-01-01

    In large-scale wireless sensor networks (WSNs), in order to enhance network security, it is crucial for a trustor node to perform social milieu oriented routing to a target a trustee node to carry out trust evaluation. This challenging social milieu oriented routing with more than one end-to-end Quality of Trust (QoT) constraint has proved to be NP-complete. Heuristic algorithms with polynomial and pseudo-polynomial-time complexities are often used to deal with this challenging problem. However, existing solutions cannot guarantee the efficiency of searching; that is, they can hardly avoid obtaining partial optimal solutions during a searching process. Quantum annealing (QA) uses delocalization and tunneling to avoid falling into local minima without sacrificing execution time. This has been proven a promising way to many optimization problems in recently published literatures. In this paper, for the first time, with the help of a novel approach, that is, configuration path-integral Monte Carlo (CPIMC) simulations, a QA-based optimal social trust path (QA_OSTP) selection algorithm is applied to the extraction of the optimal social trust path in large-scale WSNs. Extensive experiments have been conducted, and the experiment results demonstrate that QA_OSTP outperforms its heuristic opponents. PMID:26907277

  8. Social Milieu Oriented Routing: A New Dimension to Enhance Network Security in WSNs

    PubMed Central

    Liu, Lianggui; Chen, Li; Jia, Huiling

    2016-01-01

    In large-scale wireless sensor networks (WSNs), in order to enhance network security, it is crucial for a trustor node to perform social milieu oriented routing to a target a trustee node to carry out trust evaluation. This challenging social milieu oriented routing with more than one end-to-end Quality of Trust (QoT) constraint has proved to be NP-complete. Heuristic algorithms with polynomial and pseudo-polynomial-time complexities are often used to deal with this challenging problem. However, existing solutions cannot guarantee the efficiency of searching; that is, they can hardly avoid obtaining partial optimal solutions during a searching process. Quantum annealing (QA) uses delocalization and tunneling to avoid falling into local minima without sacrificing execution time. This has been proven a promising way to many optimization problems in recently published literatures. In this paper, for the first time, with the help of a novel approach, that is, configuration path-integral Monte Carlo (CPIMC) simulations, a QA-based optimal social trust path (QA_OSTP) selection algorithm is applied to the extraction of the optimal social trust path in large-scale WSNs. Extensive experiments have been conducted, and the experiment results demonstrate that QA_OSTP outperforms its heuristic opponents. PMID:26907277

  9. Impact of the Uremic Milieu on the Osteogenic Potential of Mesenchymal Stem Cells

    PubMed Central

    Lanza, Diana; Perna, Alessandra F.; Oliva, Adriana; Vanholder, Raymond; Pletinck, Anneleen; Guastafierro, Salvatore; Di Nunzio, Annarita; Vigorito, Carmela; Capasso, Giovambattista; Jankowski, Vera; Jankowski, Joachim; Ingrosso, Diego

    2015-01-01

    Human mesenchymal stem cells (hMSCs), the precursors of osteoblasts during osteogenesis, play a role in the balance of bone formation and resorption, but their functioning in uremia has not been well defined. To study the effects of the uremic milieu on osteogenic properties, we applied an in vitro assay culturing hMSCs in osteogenic medium supplemented with serum from healthy donors and from uremic patients on hemodialysis. Compared to control, serum from uremic patients induces, in hMSC cultures, a modification of several key regulators of bone remodeling, in particular a reduction of the ratio Receptor Activator of Nuclear factor Kappa B Receptor (RANKL) over osteoprotegerin, indicating an adaptive response of the system to favor osteogenesis over osteoclastosis. However, the levels of osteopontin, osteocalcin, and collagen type I, are increased in cell medium, while BMP-2, and alizarin red staining were decreased, pointing to a reduction of bone formation favoring resorption. Selected uremic toxins, such as p-cresylsulfate, p-cresylglucuronide, parathyroid hormone, indoxyl sulfate, asymmetric dimethylarginine, homocysteine, were able to mimic some of the effects of whole serum from uremic patients. Serum from cinacalcet-treated patients antagonizes these effects. Hydrogen sulfide (H2S) donors as well as hemodialysis treatment are able to induce beneficial effects. In conclusion, bone modifications in uremia are influenced by the capability of the uremic milieu to alter hMSC osteogenic differentiation. Cinacalcet, H2S donors and a hemodialysis session can ameliorate the hampered calcium deposition. PMID:25635832

  10. Social Milieu Oriented Routing: A New Dimension to Enhance Network Security in WSNs.

    PubMed

    Liu, Lianggui; Chen, Li; Jia, Huiling

    2016-02-19

    In large-scale wireless sensor networks (WSNs), in order to enhance network security, it is crucial for a trustor node to perform social milieu oriented routing to a target a trustee node to carry out trust evaluation. This challenging social milieu oriented routing with more than one end-to-end Quality of Trust (QoT) constraint has proved to be NP-complete. Heuristic algorithms with polynomial and pseudo-polynomial-time complexities are often used to deal with this challenging problem. However, existing solutions cannot guarantee the efficiency of searching; that is, they can hardly avoid obtaining partial optimal solutions during a searching process. Quantum annealing (QA) uses delocalization and tunneling to avoid falling into local minima without sacrificing execution time. This has been proven a promising way to many optimization problems in recently published literatures. In this paper, for the first time, with the help of a novel approach, that is, configuration path-integral Monte Carlo (CPIMC) simulations, a QA-based optimal social trust path (QA_OSTP) selection algorithm is applied to the extraction of the optimal social trust path in large-scale WSNs. Extensive experiments have been conducted, and the experiment results demonstrate that QA_OSTP outperforms its heuristic opponents.

  11. The mare as a model for luteinized unruptured follicle syndrome: intrafollicular endocrine milieu.

    PubMed

    Bashir, S T; Gastal, M O; Tazawa, S P; Tarso, S G S; Hales, D B; Cuervo-Arango, J; Baerwald, A R; Gastal, E L

    2016-03-01

    Luteinized unruptured follicle (LUF) syndrome is a recurrent anovulatory dysfunction that affects up to 23% of women with normal menstrual cycles and up to 73% with endometriosis. Mechanisms underlying the development of LUF syndrome in mares were studied to provide a potential model for human anovulation. The effect of extended increase in circulating LH achieved by administration of recombinant equine LH (reLH) or a short surge of LH and decrease in progesterone induced by prostaglandin F2α (PGF2α) on LUF formation (Experiment 1), identification of an optimal dose of COX-2 inhibitor (flunixin meglumine, FM; to block the effect of prostaglandins) for inducing LUFs (Experiment 2), and evaluation of intrafollicular endocrine milieu in LUFs (Experiment 3) were investigated. In Experiment 1, mares were treated with reLH from Day 7 to Day 15 (Day 0=ovulation), PGF2α on Day 7, or in combination. In Experiment 2, FM at doses of 2.0 or 3.0 mg/kg every 12 h and human chorionic gonadotropin (hCG) (1500 IU) were administered after a follicle ≥32 mm was detected. In Experiment 3, FM at a dose of 2.0 mg/kg every 12 h plus hCG was used to induce LUFs and investigate the intrafollicular endocrine milieu. No LUFs were induced by reLH or PGF2α treatment; however, LUFs were induced in 100% of mares using FM. Intrafollicular PGF2α metabolite, PGF2α, and PGE2 were lower and the ratio of PGE2:PGF2α was higher in the induced LUF group. Higher levels of intrafollicular E2 and total primary sex steroids were observed in the induced LUF group along with a tendency for higher levels of GH, cortisol, and T; however, LH, PRL, VEGF-A, and NO did not differ between groups. In conclusion, this study reveals part of the intrafollicular endocrine milieu and the association of prostaglandins in LUF formation, and indicates that the mare might be an appropriate model for studying the poorly understood LUF syndrome.

  12. Partisans and Provincials: The Political Milieu of State-Supported Education in Illinois, 1870-1920. Yale Higher Education Program Working Paper, YHEP-5.

    ERIC Educational Resources Information Center

    McKenna, Jon F.

    The shifting political milieu which surrounded and conditioned all of Illinois' educational endeavors in the half century after 1870 is discussed. Studies of those elements of society which have influenced the development of schools have often neglected the political milieu that affects educational policy-making at the state level. The political…

  13. Neutrophils alter the inflammatory milieu by signal-dependent translation of constitutive messenger RNAs

    NASA Astrophysics Data System (ADS)

    Lindemann, Stephan W.; Yost, Christian C.; Denis, Melvin M.; McIntyre, Thomas M.; Weyrich, Andrew S.; Zimmerman, Guy A.

    2004-05-01

    The mechanisms by which neutrophils, key effector cells of the innate immune system, express new gene products in inflammation are largely uncharacterized. We found that they rapidly translate constitutive mRNAs when activated, a previously unrecognized response. One of the proteins synthesized without a requirement for transcription is the soluble IL-6 receptor , which translocates to endothelial cells and induces a temporal switch to mononuclear leukocyte recruitment. Its synthesis is regulated by a specialized translational control pathway that is inhibited by rapamycin, a bacterial macrolide with therapeutic efficacy in transplantation, inflammatory syndromes, and neoplasia. Signal-dependent translation in activated neutrophils may be a critical mechanism for alteration of the inflammatory milieu and a therapeutic target.

  14. Rocky milieu: challenges of effective integration of clinical risk management into hospitals in Iran.

    PubMed

    Farokhzadian, Jamileh; Nayeri, Nahid Dehghan; Borhani, Fariba

    2015-01-01

    Healthcare risks and clinical risks have been recognized as a major challenge in healthcare. Clinical risks can never be eliminated and can have serious adverse effects on patient safety. Thus, a clinical risk management (CRM) system has been introduced in the healthcare system to improve quality services. The aim of this study was to explore nurses' experiences related to the challenges of implementing CRM in the organizational context. This qualitative study was based on the conventional content analysis of the Lundman and Graneheim approach, and it consisted of 22 interview sessions with 20 nurses. The purposive sampling method was used to choose the participants from three hospitals affiliated with the Kerman University of Medical Sciences. We used semi-structured interviews and review of relevant documents to collect data. The analysis of the data led to the emergence of "rocky milieu" as the main theme, and it consisted of three categories that, along with their subcategories, explain the challenges of implementing CRM. The three categories and their subcategories were (1) organizational culture and leadership challenges (decision and performance of leadership and cultural resistance to change), (2) limitation of resources (financial, human, and physical and equipment resources), and (3) variations and complexities in working conditions (the emotional, psychological, and social atmosphere and the heaviness of workload). Attempts have been made to establish CRM through clinical governance and accreditation, but organizational challenges have created a rocky milieu for implementing CRM. However, from an organizational context concerning the suitability of healthcare in Iran, there are obvious needs to move toward quality improvement and safe practices through the effective implementation of CRM. PMID:25968444

  15. Epigenetic Modulation of Human Podocyte Vitamin D Receptor in HIV Milieu.

    PubMed

    Chandel, Nirupama; Ayasolla, Kameshwar S; Lan, Xiqian; Sultana-Syed, Maria; Chawla, Amrita; Lederman, Rivka; Vethantham, Vasupradha; Saleem, Moin A; Chander, Praveen N; Malhotra, Ashwani; Singhal, Pravin C

    2015-10-01

    HIV (human immunodeficiency virus) has been reported to induce podocyte injury through down regulation of vitamin D receptor (VDR) and activation of renin angiotensin system; however, the involved mechanism is not clear. Since HIV has been reported to modulate gene expression via epigenetic phenomena, we asked whether epigenetic factors contribute to down regulation of VDR. Kidney cells in HIV transgenic mice and HIV-infected podocytes (HIV/HPs) displayed enhanced expression of SNAIL, a repressor of VDR. To elucidate the mechanism, we studied the effect of HIV on expression of molecules involved in SNAIL repressor complex formation and demonstrated that HIV enhances expression of the histone deacetylase HDAC1 and DNA methyl transferases DNMT3b and DNMT1. 293T cells, when stably transfected with SNAIL (SNAIL/293T), displayed suppressed transcription and translation of VDR. In SNAIL/293T cells, co-immunoprecipitation studies revealed the association of HDAC1, DNMT3b, DNMT1, and mSin3A with SNAIL. Chromatin immunoprecipitation experiments confirmed the presence of the SNAIL repressor complex at the VDR promoter. Consistent with the enhanced DNA methyl transferase expression in HIV/HPs, there was an increased CpG methylation at the VDR promoter. Chromatin immunoprecipitation assay confirmed occurrence of H3K4 trimethylation on SNAIL promoter. Neither a VDR agonist (VDA) nor an HDAC inhibitor (HDACI) nor a demethylating agent (DAC) individually could optimally up regulate VDR in HIV milieu. However, VDA and HDACI when combined were successful in de-repressing VDR expression. Our findings demonstrate that SNAIL recruits multiple chromatin enzymes to form a repressor complex in HIV milieu that down regulates VDR expression.

  16. A pipeline for determining protein-protein interactions and proximities in the cellular milieu.

    PubMed

    Subbotin, Roman I; Chait, Brian T

    2014-11-01

    It remains extraordinarily challenging to elucidate endogenous protein-protein interactions and proximities within the cellular milieu. The dynamic nature and the large range of affinities of these interactions augment the difficulty of this undertaking. Among the most useful tools for extracting such information are those based on affinity capture of target bait proteins in combination with mass spectrometric readout of the co-isolated species. Although highly enabling, the utility of affinity-based methods is generally limited by difficulties in distinguishing specific from nonspecific interactors, preserving and isolating all unique interactions including those that are weak, transient, or rapidly exchanging, and differentiating proximal interactions from those that are more distal. Here, we have devised and optimized a set of methods to address these challenges. The resulting pipeline involves flash-freezing cells in liquid nitrogen to preserve the cellular environment at the moment of freezing; cryomilling to fracture the frozen cells into intact micron chunks to allow for rapid access of a chemical reagent and to stabilize the intact endogenous subcellular assemblies and interactors upon thawing; and utilizing the high reactivity of glutaraldehyde to achieve sufficiently rapid stabilization at low temperatures to preserve native cellular interactions. In the course of this work, we determined that relatively low molar ratios of glutaraldehyde to reactive amines within the cellular milieu were sufficient to preserve even labile and transient interactions. This mild treatment enables efficient and rapid affinity capture of the protein assemblies of interest under nondenaturing conditions, followed by bottom-up MS to identify and quantify the protein constituents. For convenience, we have termed this approach Stabilized Affinity Capture Mass Spectrometry. Here, we demonstrate that Stabilized Affinity Capture Mass Spectrometry allows us to stabilize and elucidate

  17. The exercise-induced biochemical milieu enhances collagen content and tensile strength of engineered ligaments.

    PubMed

    West, Daniel W D; Lee-Barthel, Ann; McIntyre, Todd; Shamim, Baubak; Lee, Cassandra A; Baar, Keith

    2015-10-15

    Exercise stimulates a dramatic change in the concentration of circulating hormones, such as growth hormone (GH), but the biological functions of this response are unclear. Pharmacological GH administration stimulates collagen synthesis; however, whether the post-exercise systemic milieu has a similar action is unknown. We aimed to determine whether the collagen content and tensile strength of tissue-engineered ligaments is enhanced by serum obtained post-exercise. Primary cells from a human anterior cruciate ligament (ACL) were used to engineer ligament constructs in vitro. Blood obtained from 12 healthy young men 15 min after resistance exercise contained GH concentrations that were ∼7-fold greater than resting serum (P < 0.001), whereas IGF-1 was not elevated at this time point (P = 0.21 vs. rest). Ligament constructs were treated for 7 days with medium supplemented with serum obtained at rest (RestTx) or 15 min post-exercise (ExTx), before tensile testing and collagen content analysis. Compared with RestTx, ExTx enhanced collagen content (+19%; 181 ± 33 vs. 215 ± 40 μg per construct P = 0.001) and ligament mechanical properties - maximal tensile load (+17%, P = 0.03 vs. RestTx) and ultimate tensile strength (+10%, P = 0.15 vs. RestTx). In a separate set of engineered ligaments, recombinant IGF-1, but not GH, enhanced collagen content and mechanics. Bioassays in 2D culture revealed that acute treatment with post-exercise serum activated mTORC1 and ERK1/2. In conclusion, the post-exercise biochemical milieu, but not recombinant GH, enhances collagen content and tensile strength of engineered ligaments, in association with mTORC1 and ERK1/2 activation.

  18. Effects of a Modified Milieu Therapy Intervention on the Social Communicative Behaviors of Young Children with Autism Spectrum Disorders

    ERIC Educational Resources Information Center

    Mancil, G. Richmond; Conroy, Maureen A.; Haydon, Todd F.

    2009-01-01

    The purpose of the current study was to evaluate the effectiveness of combining milieu therapy and functional communication training (FCT) to replace aberrant behavior with functional communicative skills in 3 male preschool or elementary aged children with Autism Spectrum Disorders (ASD). Study activities were conducted in the natural…

  19. The Effects of Enhanced Milieu Teaching and a Voice Output Communication Aid on the Requesting of Three Children with Autism

    ERIC Educational Resources Information Center

    Olive, Melissa L.; de la Cruz, Berenice; Davis, Tonya N.; Chan, Jeffrey M.; Lang, Russell B.; O'Reilly, Mark F.; Dickson, Sarah M.

    2007-01-01

    The purpose of this study was to evaluate the effects of enhanced milieu teaching when combined with a voice output communication aid on the requesting skills of three children with autism. The research design was a multiple probe across participants. All sessions were conducted during 5-min play sessions in the child's classroom. All three…

  20. A Comparative-Qualitative Research Analysis of Character Education in the Christian School and Home Education Milieu

    ERIC Educational Resources Information Center

    Wilhelm, Gretchen Marie

    2005-01-01

    This qualitative study provides a phenomenological perspective and comparative analysis of character education within the Christian school and home education milieu. The study is based on semi-structured interviews of fifty-two individuals (N = 52) representative of a sampling of Christian educators from four private, evangelical Christian Schools…

  1. Non-targeted metabolomic evaluation of the uterine milieu during the transitional period of embryo elongation in the pig

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Alterations in the signaling of critical molecular factors within the uterine milieu lead to deficiencies in embryo elongation. The objective of this study was to identify metabolites within the uterine environment that are present as porcine embryos transition between spherical, ovoid, and tubular ...

  2. The Response of Human Macrophages to β-Glucans Depends on the Inflammatory Milieu

    PubMed Central

    Montero, Olimpio; Hugo, Etzel; Rodríguez, Mario; Domingo, Esther; Alonso, Sara

    2013-01-01

    Background β-glucans are fungal cell wall components that bind to the C-type lectin-like receptor dectin-1. Polymorphisms of dectin-1 gene are associated with susceptibility to invasive fungal infection and medically refractory ulcerative colitis. The purpose of this study has been addressing the response of human macrophages to β-glucans under different conditions mimicking the composition of the inflammatory milieu in view of the wide plasticity and large range of phenotypical changes showed by these cells, and the relevant role of dectin-1 in several pathophysiological conditions. Principal Findings Serum-differentiated macrophages stimulated with β-glucans showed a low production of TNFα and IL-1β, a high production of IL-6 and IL-23, and a delayed induction of cyclooxygenase-2 and PGE2 biosynthesis that resembled the responses elicited by crystals and those produced when phagosomal degradation of the phagocytic cargo increases ligand access to intracellular pattern recognition receptors. Priming with a low concentration of LPS produced a rapid induction of cyclooxygenase-2 and a synergistic release of PGE2. When the differentiation of the macrophages was carried out in the presence of M-CSF, an increased expression of dectin-1 B isoform was observed. In addition, this treatment made the cells capable to release arachidonic acid in response to β-glucan. Conclusions These results indicate that the macrophage response to fungal β-glucans is strongly influenced by cytokines and microbial-derived factors that are usual components of the inflammatory milieu. These responses can be sorted into three main patterns i) an elementary response dependent on phagosomal processing of pathogen-associated molecular patterns and/or receptor-independent, direct membrane binding linked to the immunoreceptor tyrosine-based activation motif-bearing transmembrane adaptor DNAX-activating protein 12, ii) a response primed by TLR4-dependent signals, and iii) a response dependent

  3. Coacervate whey protein improves inflammatory milieu in mice fed with high-fat diet

    PubMed Central

    2014-01-01

    Background Functional foods with bioactive properties may help in treat obesity, as they can lead to a decreased risks of inflammatory diseases. The aim of this study was to investigate the effects of chitosan coacervate whey protein on the proinflammatory processes in mice fed with high-fat diet. Methods Mice were divided into two groups receiving either a normolipidic or high-fat diet; the animals in each of the two diet groups were given a diet supplement of either coacervate (gavage, 36 mg protein/kg of body weight) or tap water for four weeks [groups: normolipidic diet plus water (C); normolipidic diet and coacervate (CC); high-fat diet and water (H); and high-fat diet and coacervate (HC)]. Results The high-fat diet promoted inflammation, possibly by decreased adiponectin/sum of adipose tissues ratio and increased phosphorylation of NF-κB p50. In HC we observed a positive correlation between IL-10 and TNF-α in mesenteric adipose tissue, retroperitoneal adipose tissue and liver tissue. We also observed a positive correlation between lipopolisaccharide with IL-10 in the liver tissue. Conclusions High-fat diet treatment promoted metabolic alterations and inflammation, and chitosan coacervate whey protein modulated inflammatory milieu. PMID:24673809

  4. Cognitive milieu therapy and physical activity: experiences of mastery and learning among patients with dual diagnosis.

    PubMed

    Borge, L; Røssberg, J I; Sverdrup, S

    2013-12-01

    During the last decade, there has been a growing interest in implementing cognitive milieu therapy (CMT) in psychiatric institutions. However, there is a lack of systematic evaluations from patients' point of view. The aim of this study was to explore and describe patient perceptions of essential experiences of mastery, learning alternative ways of thinking, and acquiring new skills through CMT and physical activity in an inpatient setting. Qualitative interviews were carried out with 20 patients with dual diagnosis. A hermeneutic - phenomenological approach was used in the data collection and analysis. The results showed that the learning climate in the unit was important. This included a proactive attitude from the staff, focusing on cooperation on equal terms between patients and staff, and a professional methodological approach through CMT. The optimal balance between staff-induced activities and patient initiatives was not easy to obtain. Patients appreciated both the education provided by the staff and learning from other patients. The cognitive method was sometimes experienced as too theoretical and difficult to understand. Physical activity, however, was experienced as 'concrete' and providing practical knowledge. It motivated patients to establish new habits and provided opportunities for the development of mastery together with other patients.

  5. Culturally diverse Malayan milieu: experiences and perceptions of RAANC nurses 1955-1960.

    PubMed

    McLeod, Margaret

    2007-07-01

    The war exploits of Australian Army nurses have been represented in a number of literary sources, but there is a paucity of data about the nurses who served in the Malayan Emergency (1948-1960). Using descriptive interpretive historiography, with a central focus on oral testimony, this paper aims to highlight the culturally rich and diverse environment of Malaya in the 1950s. Semi-structured interviews were conducted with four women from the Royal Australian Army Nursing Corps to expose their experiences and perceptions of the Malayan environment and its people. The information provided by these nurses was subjected to manual thematic analysis resulting in the emergence of a number of themes. One prominent theme, Malaya's cultural diversity, was chosen for this paper because it contained an abundant source of new and rich data. To protect the identities of the informants pseudonyms were used in the presentation of the oral narratives. This approach led to revelations about how Australian women, with limited knowledge or exposure to other cultural groups, engaged in work and leisure time pursuits in Malaya's exotic cultural milieu.

  6. Influence of oral metronidazole on the endocrine milieu and sebum excretion rate.

    PubMed

    Aizawa, H; Niimura, M; Kon, Y

    1992-12-01

    As part of a study of the mechanism of metronidazole's efficacy in the treatment of acne and rosacea, its effects on the endocrine milieu and sebum excretion rate were assessed. Thirteen healthy males received oral metronidazole treatment (500 mg/day) for 4 weeks. Serum sex hormone levels were determined in all 13 subjects and the sebum excretion rate was determined in seven of them, before and after treatment. We measured serum levels of estrone (E1), estradiol (E2), total testosterone (T), free testosterone (FT), dihydrotestosterone (DHT), dehydroepiandrosterone sulfate (DHEA-S), and sex hormone-binding globulin (SHBG). There were no significant changes in E1, T, FT, DHT, or SHBG levels, but E2 and DHEA-S levels decreased significantly after treatment. In all seven subjects in whom the sebum excretion rates were determined, the amount of facial skin surface lipids decreased significantly after treatment. These results suggest that metronidazole exerts its clinical effects through suppressing the sebum excretion by a mechanism other than anti-androgenic action. PMID:1293188

  7. Is More Better? Milieu Communication Teaching in Toddlers With Intellectual Disabilities

    PubMed Central

    Fey, Marc E.; Yoder, Paul J.; Warren, Steven F.; Bredin-Oja, Shelley L.

    2013-01-01

    Purpose The authors sought to determine whether a program of 5 weekly doses of milieu communication teaching (MCT) would yield improvements in children’s communication and word use compared with a once-weekly delivery of the same treatment. Method Sixty-four children with intellectual and communication delay were randomly assigned to receive 60-min sessions of MCT either 1 time or 5 times per week over a 9-month treatment. Growth curves were fit to data collected at 5 points before, during, and after the MCT was delivered. Results With groups collapsed, significant growth across the experimental period was observed on all measures, but this was not associated unconditionally with treatment intensity. Children who played with 9 or more objects during a standard play assessment, an empirically identified cut-point, benefitted more from the high- than from the low-intensity treatment on lexical measures (Hedges’s g range = .49 to .65). Conclusions More MCT is not always better for all children. Clinicians can expect that increasing the frequency of MCT sessions will yield moderate enhancement of outcomes if the child has high interest in objects. PMID:23275404

  8. Protein unfolding in crowded milieu: what crowding can do to a protein undergoing unfolding?

    PubMed

    Stepanenko, Olga V; Povarova, Olga I; Sulatskaya, Anna I; Ferreira, Luisa A; Zaslavsky, Boris Y; Kuznetsova, Irina M; Turoverov, Konstantin K; Uversky, Vladimir N

    2016-10-01

    The natural environment of a protein inside a cell is characterized by the almost complete lack of unoccupied space, limited amount of free water, and the tightly packed crowd of various biological macromolecules, such as proteins, nucleic acids, polysaccharides, and complexes thereof. This extremely crowded natural milieu is poorly mimicked by slightly salted aqueous solutions containing low concentrations of a protein of interest. The accepted practice is to model crowded environments by adding high concentrations of various polymers that serve as model "crowding agents" to the solution of a protein of interest. Although studies performed under these model conditions revealed that macromolecular crowding might have noticeable influence on various aspects related to the protein structure, function, folding, conformational stability, and aggregation propensity, the complete picture describing conformational behavior of a protein under these conditions is missing as of yet. Furthermore, there is an accepted belief that the conformational stability of globular proteins increases in the presence crowding agents due to the excluded volume effects. The goal of this study was to conduct a systematic analysis of the effect of high concentrations of PEG-8000 and Dextran-70 on the unfolding behavior of eleven globular proteins belonging to different structural classes. PMID:26474212

  9. Connexin 43 stabilizes astrocytes in a stroke-like milieu to facilitate neuronal recovery

    PubMed Central

    Wu, Le-yu; Yu, Xue-li; Feng, Lin-yin

    2015-01-01

    Aim: Connexin 43 (Cx43) is a member of connexin family mainly expressed in astrocytes, which forms gap junctions and hemichannels and maintains the normal shape and function of astrocytes. In this study we investigated the role of Cx43 in astrocytes in facilitating neuronal recovery during ischemic stroke. Methods: Primary culture of astrocytes or a mixed culture of astrocytes and cortical neurons was subjected to oxygen glucose deprivation and reperfusion (OGD/R). The expression of Cx43 and Ephrin-A4 in astrocytes was detected using immunocytochemical staining and Western blot assays. Intercellular Ca2+ concentration was determined with Fluo-4 AM fluorescent staining. Middle cerebral artery occlusion (MCAO) model rats were used for in vivo studies. Results: OGD/R treatment of cultured astrocytes caused a decrement of Cx43 expression and translocation of Cx43 from cell membrane to cytoplasm, accompanied by cell retraction. Furthermore, OGD/R increased intracellular Ca2+ concentration, activated CaMKII/CREB pathways and upregulated expression of Ephrin-A4 in the astrocytes. All these changes in OGD/R-treated astrocytes were alleviated by overexpression of Cx43. In the cortical neurons cultured with astrocytes, OGD/R inhibited the neurite growth, whereas overexpression of Cx43 or knockdown of Ephrin-A4 in astrocytes restored the neurite growth. In MCAO model rats, neuronal recovery was found to be correlated with the recuperation of Cx43 and Ephrin-A4 in astrocytes. Conclusion: Cx43 can stabilize astrocytes and facilitate the resistance to the deleterious effects of a stroke-like milieu and promote neuronal recovery. PMID:26095039

  10. Does HIV Exploit the Inflammatory Milieu of the Male Genital Tract for Successful Infection?

    PubMed Central

    Esra, Rachel T.; Olivier, Abraham J.; Passmore, Jo-Ann S.; Jaspan, Heather B.; Harryparsad, Rushil; Gray, Clive M.

    2016-01-01

    In many parts of the World, medical male circumcision (MMC) is used as standard prevention of care against HIV infection. This is based on seminal reports made over 10 years ago that removal of the foreskin provides up to 60% protection against HIV infection in males and seems currently the best antiretroviral-free prevention strategy yet against the global epidemic. We explore the potential mechanisms by which MMC protects against HIV-1 acquisition and that one of the oldest, albeit re-invented, rituals of removing a foreskin underscores the exploitative nature of HIV on the anatomy and tissue of the uncircumcised penis. Furthermore, foreskin removal also reveals how males acquire HIV, and in reality, the underlying mechanisms of MMC are not known. We argue that the normal sequelae of inflammation in the male genital tract (MGT) for protection from sexually transmitted infections (STI)-induced pathology represents a perfect immune and microbial ecosystem for HIV acquisition. The accumulation of HIV-1 target cells in foreskin tissue and within the urethra in response to STIs, both during and after resolution of infection, suggests that acquisition of HIV-1, through sexual contact, makes use of the natural immune milieu of the MGT. Understanding immunity in the MGT, the movement of HIV-1 target cells to the urethra and foreskin tissue upon encounter with microbial signals would provide more insight into viral acquisition and lay the foundation for further prevention strategies in males that would be critical to curb the epidemic in all sexual partners at risk of infection. The global female-centric focus of HIV-1 transmission and acquisition research has tended to leave gaps in our knowledge of what determines HIV-1 acquisition in men and such understanding would provide a more balanced and complete view of viral acquisition. PMID:27446076

  11. Rocky milieu: Challenges of effective integration of clinical risk management into hospitals in Iran

    PubMed Central

    Farokhzadian, Jamileh; Nayeri, Nahid Dehghan; Borhani, Fariba

    2015-01-01

    Healthcare risks and clinical risks have been recognized as a major challenge in healthcare. Clinical risks can never be eliminated and can have serious adverse effects on patient safety. Thus, a clinical risk management (CRM) system has been introduced in the healthcare system to improve quality services. The aim of this study was to explore nurses’ experiences related to the challenges of implementing CRM in the organizational context. This qualitative study was based on the conventional content analysis of the Lundman and Graneheim approach, and it consisted of 22 interview sessions with 20 nurses. The purposive sampling method was used to choose the participants from three hospitals affiliated with the Kerman University of Medical Sciences. We used semi-structured interviews and review of relevant documents to collect data. The analysis of the data led to the emergence of “rocky milieu” as the main theme, and it consisted of three categories that, along with their subcategories, explain the challenges of implementing CRM. The three categories and their subcategories were (1) organizational culture and leadership challenges (decision and performance of leadership and cultural resistance to change), (2) limitation of resources (financial, human, and physical and equipment resources), and (3) variations and complexities in working conditions (the emotional, psychological, and social atmosphere and the heaviness of workload). Attempts have been made to establish CRM through clinical governance and accreditation, but organizational challenges have created a rocky milieu for implementing CRM. However, from an organizational context concerning the suitability of healthcare in Iran, there are obvious needs to move toward quality improvement and safe practices through the effective implementation of CRM. PMID:25968444

  12. Pituitary Adenlylate Cyclase Activating Peptide Protects Adult Neural Stem Cells from a Hypoglycaemic milieu

    PubMed Central

    Mansouri, Shiva; Lietzau, Grazyna; Lundberg, Mathias; Nathanson, David; Nyström, Thomas; Patrone, Cesare

    2016-01-01

    Hypoglycaemia is a common side-effect of glucose-lowering therapies for type-2 diabetic patients, which may cause cognitive/neurological impairment. Although the effects of hypoglycaemia in the brain have been extensively studied in neurons, how hypoglycaemia impacts the viability of adult neural stem cells (NSCs) has been poorly investigated. In addition, the cellular and molecular mechanisms of how hypoglycaemia regulates NSCs survival have not been characterized. Recent work others and us have shown that the pituitary adenylate cyclase-activating polypeptide (PACAP) and the glucagon-like peptide-1 receptor (GLP-1R) agonist Exendin-4 stimulate NSCs survival against glucolipoapoptosis. The aim of this study was to establish an in vitro system where to study the effects of hypoglycaemia on NSC survival. Furthermore, we determine the potential role of PACAP and Exendin-4 in counteracting the effect of hypoglycaemia. A hypoglycaemic in vitro milieu was mimicked by exposing subventricular zone-derived NSC to low levels of glucose. Moreover, we studied the potential involvement of apoptosis and endoplasmic reticulum stress by quantifying protein levels of Bcl-2, cleaved caspase-3 and mRNA levels of CHOP. We show that PACAP via PAC-1 receptor and PKA activation counteracts impaired NSC viability induced by hypoglycaemia. The protective effect induced by PACAP correlated with endoplasmic reticulum stress, Exendin-4 was ineffective. The results show that hypoglycaemia decreases NSC viability and that this effect can be substantially counteracted by PACAP via PAC-1 receptor activation. The data supports a potential therapeutic role of PAC-1 receptor agonists for the treatment of neurological complications, based on neurogenesis impairment by hypoglycaemia. PMID:27305000

  13. Les valvulopathies cardiaques en milieu hospitalier à Lomé (Togo)

    PubMed Central

    Balaka, Abago; Tchamdja, Toyi; Djibril, Mohaman Awalou; Djagadou, Kodjo Agbéko; Tchandana, Makilioubè; Damorou, Findibé; Agbétra, Aïssah

    2015-01-01

    Introduction Notre étude a consisté en l'identification les principales valvulopathies retrouvées en milieu hospitalier à Lomé (Togo). Méthodes Il s'agit d'une étude rétrospective, transversale, multicentrique menée du 1er janvier 2006 au 31 décembre 2010 et portant sur les dossiers de patients suivis dans le service de cardiologie du CHU Campus de Lomé. Résultats Du 1er janvier 2006 au 31 Décembre 2010,5412 patients ont été consulté dans le service de cardiologie du CHU Campus. Parmi eux, 241 (4,45%) présentaient une valvulopathie. On notait une prédominance féminine avec un sex-ratio H/F à 0,60. La moyenne d’âge était de 62,32 ans avec des extrêmes allant de 16 à 89 ans et un écart type de 14,27. Les antécédents le plus souvent retrouvés étaient l'hypertension artérielle (26,97%) et le diabète (8,29%). Parmi les motifs de consultations, les plus fréquents étaient la dyspnée (39,00%), les précordialgies (32,78%) et les palpitations (21,16%). A l'examen physique 30,70% des patients présentaient des signes de d'insuffisance cardiaque. A l’échographie, on notait des atteintes d'une seule valve (77,17%), de 02 valves (17,42%) ou 03 valves (5,4%). L'insuffisance mitrale (56,84%) et l'insuffisance aortique (30,70%) ont été les valvulopathies les plus fréquemment retrouvées. La maladie mitrale a été notée chez 05 patients. Les principales étiologies étaient dégénératives et ischémiques. Conclusion Les valvulopathies sont relativement fréquentes à Lomé. L'insuffisance cardiaque est leur principal mode de révélation. Les plus retrouvées sont l'insuffisance mitrale et aortique. PMID:26113911

  14. Release of hydrogen peroxide and antioxidants by the coral Stylophora pistillata to its external milieu

    NASA Astrophysics Data System (ADS)

    Armoza-Zvuloni, R.; Shaked, Y.

    2014-09-01

    Hydrogen peroxide (H2O2), a common reactive oxygen species, plays multiple roles in coral health and disease. Elevated H2O2 production by the symbiotic algae during stress may result in symbiosis breakdown and bleaching of the coral. We have recently reported that various Red Sea corals release H2O2 and antioxidants to their external milieu, and can influence the H2O2 dynamics in the reef. Here, we present a laboratory characterization of H2O2 and antioxidant activity release kinetics by intact, non-stressed Stylophora pistillata. Experimenting with bleached and non-bleached corals and different stirring speeds, we explored the sources and modes of H2O2 and antioxidant release. Since H2O2 is produced and degraded simultaneously, we developed a methodology for resolving the actual H2O2 concentrations released by the corals. H2O2 and antioxidant activity steadily increased in the water surrounding the coral over short periods of 1-2 h. Over longer periods of 5-7 h, the antioxidant activity kept increasing with time, while H2O2 concentrations were stabilized at ~ 1 μM by 1-3 h, and then gradually declined. Solving for H2O2 release, corals were found to release H2O2 at increasing rates over 2-4 h, and then to slow down and stop by 5-7 h. Stirring was shown to induce the release of H2O2, possibly since the flow reduces the thickness of the diffusive boundary layer of the coral, and thus increases H2O2 mass flux. Antioxidant activity was released at similar rates by bleached and non-bleached corals, suggesting that the antioxidants did not originate from the symbiotic algae. H2O2, however, was not released from bleached corals, implying that the symbiotic algae are the source of the released H2O2. The observed flow-induced H2O2 release may aid corals in removing some of the internal H2O2 produced by their symbiotic algae, and may possibly assist in preventing coral bleaching under conditions of elevated temperature and irradiance.

  15. Release of hydrogen peroxide and antioxidant by the coral Stylophora pistillata to its external milieu

    NASA Astrophysics Data System (ADS)

    Armoza-Zvuloni, R.; Shaked, Y.

    2014-01-01

    Hydrogen peroxide (H2O2), a common reactive oxygen species, plays multiple roles in coral health and disease. Elevated H2O2 production by the symbiotic algae during stress may result in symbiosis breakdown and bleaching of the coral. We have recently reported that various Red Sea corals release H2O2 and antioxidants to their external milieu and can influence the H2O2 dynamics in the reef. Here we present laboratory characterization of H2O2 and antioxidant activity release kinetics by intact, non-stressed Stylophora pistillata. Experimenting with bleached and non-bleached corals and different stirring speeds, we explored the sources and modes of H2O2 and antioxidant release. Since H2O2 is produced and degraded simultaneously, we developed methodology for resolving the actual rates of H2O2 release by the corals. H2O2 and antioxidant activity linearly increased in the water surrounding the coral over short periods of 1-2 h. Over longer periods of 5-7 h, the antioxidant activity kept increasing with time, while H2O2 concentrations were stabilized at ~ 1 μM by 2-3 h, and then gradually declined. Solving for H2O2 release, corals were found to release H2O2 at increasing rates over 2-4 h, and then slow down and stop by 5-7 h. Stirring was shown to induce the release of both H2O2 and antioxidant activity, possibly due to ventilation of the coral by the flow. Antioxidant activity was released at similar rates by bleached and non-bleached corals, suggesting that the antioxidant did not originate from the symbiotic algae. H2O2, however, was only minimally released from bleached corals, implying that the symbiotic algae are the source of the released H2O2. The observed flow-induced H2O2 release may aid corals in removing some of the internal H2O2 produced by their symbiotic algae and possibly assist in preventing coral bleaching under conditions of elevated temperature and irradiance.

  16. Chaînes laser intenses à contraste élevé par amplification directe dans un milieu gazeux à excimères*

    NASA Astrophysics Data System (ADS)

    Uteza, O.; Tcheremiskine, V.; Clady, R.; Coustillier, G.; Gastaud, M.; Sentis, M.; Mikheev, L. D.; Chambaret, J. P.

    2006-12-01

    Cet article présente l'intérêt du concept de laser hybride (solide/gaz) et de l'amplification directe de puissance dans un milieu à excimères pour les chaînes laser de puissance ultrabrèves à contraste élevé. L'architecture d'une chaîne laser multiterawatt basée sur l'emploi du milieu amplificateur XeF(C-A) pompé par voie photolytique est ensuite détaillée, ainsi que les perspectives de dimensionnement de cette approche au niveau PWetEW.

  17. Short-Range Temporal Interactions in Sleep; Hippocampal Spike Avalanches Support a Large Milieu of Sequential Activity Including Replay.

    PubMed

    Mahoney, J Matthew; Titiz, Ali S; Hernan, Amanda E; Scott, Rod C

    2016-01-01

    Hippocampal neural systems consolidate multiple complex behaviors into memory. However, the temporal structure of neural firing supporting complex memory consolidation is unknown. Replay of hippocampal place cells during sleep supports the view that a simple repetitive behavior modifies sleep firing dynamics, but does not explain how multiple episodes could be integrated into associative networks for recollection during future cognition. Here we decode sequential firing structure within spike avalanches of all pyramidal cells recorded in sleeping rats after running in a circular track. We find that short sequences that combine into multiple long sequences capture the majority of the sequential structure during sleep, including replay of hippocampal place cells. The ensemble, however, is not optimized for maximally producing the behavior-enriched episode. Thus behavioral programming of sequential correlations occurs at the level of short-range interactions, not whole behavioral sequences and these short sequences are assembled into a large and complex milieu that could support complex memory consolidation.

  18. Soteria Berne: an innovative milieu therapeutic approach to acute schizophrenia based on the concept of affect-logic

    PubMed Central

    Ciompi, Luc; Hoffmann, Holger

    2004-01-01

    The name "Soteria" stands for an alternative low-drug milieu-therapeutic approach to acute schizophrenia that was first implemented by Mosher and Menn in San Francisco, and since 1984 further developed by Ciompi and co-workers in Berne, on the basis of their concept of affect-logic, that emphasizes the often neglected influence of emotional factors in schizophrenia. In both settings, equal and even partly better therapeutic results, compared with traditional methods, were obtained with much lower doses of antipsychotics and comparable daily costs. Basic concepts, practical proceedings and empirical findings of Soteria Berne are reported, and their theoretical and practical implications for mainstream psychiatry are discussed. They support the hypothesis of a crucial pathogenetic and therapeutic-preventive role played by emotional factors not only in the so-called affective psychoses, but also in schizophrenia. PMID:16633478

  19. Short-Range Temporal Interactions in Sleep; Hippocampal Spike Avalanches Support a Large Milieu of Sequential Activity Including Replay.

    PubMed

    Mahoney, J Matthew; Titiz, Ali S; Hernan, Amanda E; Scott, Rod C

    2016-01-01

    Hippocampal neural systems consolidate multiple complex behaviors into memory. However, the temporal structure of neural firing supporting complex memory consolidation is unknown. Replay of hippocampal place cells during sleep supports the view that a simple repetitive behavior modifies sleep firing dynamics, but does not explain how multiple episodes could be integrated into associative networks for recollection during future cognition. Here we decode sequential firing structure within spike avalanches of all pyramidal cells recorded in sleeping rats after running in a circular track. We find that short sequences that combine into multiple long sequences capture the majority of the sequential structure during sleep, including replay of hippocampal place cells. The ensemble, however, is not optimized for maximally producing the behavior-enriched episode. Thus behavioral programming of sequential correlations occurs at the level of short-range interactions, not whole behavioral sequences and these short sequences are assembled into a large and complex milieu that could support complex memory consolidation. PMID:26866597

  20. Short-Range Temporal Interactions in Sleep; Hippocampal Spike Avalanches Support a Large Milieu of Sequential Activity Including Replay

    PubMed Central

    Mahoney, J. Matthew; Titiz, Ali S.; Hernan, Amanda E.; Scott, Rod C.

    2016-01-01

    Hippocampal neural systems consolidate multiple complex behaviors into memory. However, the temporal structure of neural firing supporting complex memory consolidation is unknown. Replay of hippocampal place cells during sleep supports the view that a simple repetitive behavior modifies sleep firing dynamics, but does not explain how multiple episodes could be integrated into associative networks for recollection during future cognition. Here we decode sequential firing structure within spike avalanches of all pyramidal cells recorded in sleeping rats after running in a circular track. We find that short sequences that combine into multiple long sequences capture the majority of the sequential structure during sleep, including replay of hippocampal place cells. The ensemble, however, is not optimized for maximally producing the behavior-enriched episode. Thus behavioral programming of sequential correlations occurs at the level of short-range interactions, not whole behavioral sequences and these short sequences are assembled into a large and complex milieu that could support complex memory consolidation. PMID:26866597

  1. Ionic milieu controls the compartment-specific activation of pro-opiomelanocortin processing in AtT-20 cells.

    PubMed Central

    Schmidt, W K; Moore, H P

    1995-01-01

    Newly synthesized prohormones and their processing enzymes transit through the same compartments before being packaged into regulated secretory granules. Despite this coordinated intracellular transport, prohormone processing does not occur until late in the secretory pathway. In the mouse pituitary AtT-20 cell line, conversion of pro-opiomelanocortin (POMC) to mature adrenocorticotropic hormone involves the prohormone convertase PC1. The mechanism by which this proteolytic processing is restricted to late secretory compartments is unknown; PC1 activity could be regulated by compartment-specific activators/inhibitors, or through changes in the ionic milieu that influence its activity. By arresting transport in a semi-intact cell system, we have addressed whether metabolically labeled POMC trapped in early secretory compartments can be induced to undergo conversion if the ionic milieu in these compartments is experimentally manipulated. Prolonged incubation of labeled POMC trapped in the endoplasmic reticulum or Golgi/trans-Golgi network did not result in processing, thereby supporting the theory that processing is normally a post-Golgi/trans-Golgi network event. However, acidification of these compartments allowed effective processing of POMC to the intermediate and mature forms. The observed processing increased sharply at a pH below 6.0 and required millimolar calcium, regardless of the compartment in which labeled POMC resided. These conditions also resulted in the coordinate conversion of PC1 from the 84/87 kDa into the 74-kDa and 66-kDa forms. We propose that POMC processing is predominantly restricted to acidifying secretory granules, and that a change in pH within these granules is both necessary and sufficient to activate POMC processing. Images PMID:8573786

  2. A Comparison of High and Low Dosages of a Component of Milieu Teaching Strategies for Two Preschool-Age Learners with Autism Spectrum Disorder

    ERIC Educational Resources Information Center

    Julien, Hannah M.; Reichle, Joe

    2016-01-01

    Purpose: The intersection of treatment intensity and communication intervention is an emerging area of investigation. Milieu teaching (MT) approaches for teaching communication skills to children with autism spectrum disorder (ASD) have a substantial evidence base (see Goldstein, 2002). However, a relatively small percentage (37.8%) of MT studies…

  3. Growing up in a Dangerous Developmental Milieu: The Effects of Parenting Processes on Adjustment in Inner-City African American Adolescents

    ERIC Educational Resources Information Center

    Vazsonyi, Alexander T.; Pickering, Lloyd E.; Bolland, John M.

    2006-01-01

    The current longitudinal study examined the protective effects of parenting processes on measures of adolescent adjustment (health-compromising and violent behaviors) in a sample of high-risk, inner-city, poor African American youth N = 2,867). Parenting processes played an important role in this dangerous developmental milieu. For male…

  4. Modulatory effects of the colonic milieu on neutrophil oxidative burst: a possible pathogenic mechanism of ulcerative colitis.

    PubMed

    Keshavarzian, A; Haydek, J M; Jacyno, M; Holmes, E W; Harford, F

    1997-08-01

    An important hallmark of ulcerative colitis (UC) is mucosal neutrophil (PMN) infiltration associated with mucosal damage. This suggests that colonic chemoattractants such as bacterial products (e.g., N-formyl-methionyl-leucyl-phenylalanine (fMLP), lipopolysaccharide (LPS)) reach systemic circulation and attract PMNs to the colon. PMNs are then activated in the colonic mucosa and release their toxic oxidative metabolites. However, bacterial products are also present in the systemic circulation of healthy subjects. Thus we hypothesized that PMNs develop tolerance to colonic factors in the normal state and that this tolerance is absent in UC. We evaluated the PMN respiratory burst in response to stimulation with fMLP, LPS, or phorbol 12-myristate 13-acetate (PMA) by measuring the production of reactive oxygen species (ROS) with both luminol-enhanced chemiluminescence and a cytochrome C reduction assay. PMNs were obtained from control subjects, inactive UC patients, patients with UC who had undergone colectomies, and non-UC patients with colectomies. All three stimuli induced a significant rise in ROS. PMNs from non-UC colectomy subjects produced significantly higher ROS than PMNs from control subjects with intact colons in response to both fMLP and LPS. In contrast, PMNs from UC colectomy patients produced levels of ROS similar to those produced by PMNs from UC patients with intact colons in response to fMLP and LPS. Colectomy had no effect on PMA-induced ROS production in controls. The observed difference in fMLP-induced ROS production in control subjects with intact colons was not due to fMLP receptor down-regulation because a competition assay performed with the fMLP blocker BMLP showed a similar receptor apparent affinity in all four groups. We conclude the following: (1) the normal colonic milieu modulates the PMN respiratory burst, resulting in hyporesponsiveness of PMNs to "physiologic" but not "pharmacologic" stimulation. This effect is not due to receptor

  5. Plasma-induced signatures reveal an extracellular milieu possessing an immunoregulatory bias in treatment-naive paediatric inflammatory bowel disease.

    PubMed

    Gurram, B; Salzman, N H; Kaldunski, M L; Jia, S; Li, B U K; Stephens, M; Sood, M R; Hessner, M J

    2016-04-01

    The inflammatory state associated with Crohn's disease (CD) and ulcerative colitis (UC) remains incompletely defined. To understand more clearly the extracellular milieu associated with inflammatory bowel disease (IBD), we employed a bioassay whereby plasma of treatment naive paediatric IBD patients (n = 22 CD, n = 15 UC) and unrelated healthy controls (uHC, n = 10) were used to induce transcriptional responses in a healthy leucocyte population. After culture, gene expression was measured comprehensively with microarrays and analysed. Relative to uHC, plasma of CD and UC patients induced distinct responses consisting, respectively, of 985 and 895 regulated transcripts [|log2 ratio| ≥ 0·5 (1·4-fold); false discovery rates (FDR) ≤ 0·01]. The CD:uHC and UC:uHC signatures shared a non-random, commonly regulated, intersection of 656 transcripts (χ(2)  = P < 0·001) and were highly correlative [Pearson's correlation coefficient = 0·96, 95% confidence interval (CI) = 0.96, 0.97]. Despite sharing common genetic susceptibility loci, the IBD signature correlated negatively with that driven by plasma of type 1 diabetes (T1D) patients (Pearson's correlation coefficient = -0·51). Ontological analyses revealed the presence of an immunoregulatory plasma milieu in IBD, as transcripts for cytokines/chemokines, receptors and signalling molecules consistent with immune activation were under-expressed relative to uHC and T1D plasma. Multiplex enzyme-linked immunosorbent assay (ELISA) and receptor blockade studies confirmed transforming growth factor (TGF)-β and interleukin (IL)-10 as contributors to the IBD signature. Analysis of CD patient signatures detected a subset of transcripts associated with responsiveness to 6-mercaptopurine treatment. Through plasma-induced signature analysis, we have defined a unique, partially TGF-β/IL-10-dependent immunoregulatory signature associated with IBD that may prove useful in predicting therapeutic responsiveness

  6. A milieu of regulatory elements in the epidermal differentiation complex syntenic block: implications for atopic dermatitis and psoriasis

    PubMed Central

    de Guzman Strong, Cristina; Conlan, Sean; Deming, Clayton B.; Cheng, Jun; Sears, Karen E.; Segre, Julia A.

    2010-01-01

    Two common inflammatory skin disorders with impaired barrier, atopic dermatitis (AD) and psoriasis, share distinct genetic linkage to the Epidermal Differentiation Complex (EDC) locus on 1q21. The EDC is comprised of tandemly arrayed gene families encoding proteins involved in skin cell differentiation. Discovery of semi-dominant mutations in filaggrin (FLG) associated with AD and a copy number variation within the LCE genes associated with psoriasis provide compelling evidence for the role of EDC genes in the pathogenesis of these diseases. To date, little is known about the potentially complex regulatory landscape within the EDC. Here, we report a computational approach to identify conserved non-coding elements (CNEs) in the EDC queried for regulatory function. Coordinate expression of EDC genes during mouse embryonic skin development and a striking degree of synteny and linearity in the EDC locus across a wide range of mammalian (placental and marsupial) genomes suggests an evolutionary conserved regulatory milieu in the EDC. CNEs identified by comparative genomics exhibit dynamic regulatory activity (enhancer or repressor) in differentiating or proliferating conditions. We further demonstrate epidermal-specific, developmental in vivo enhancer activities (DNaseI and transgenic mouse assays) in CNEs, including one within the psoriasis-associated deletion, LCE3C_LCE3B-del. Together, our multidisciplinary study features a network of regulatory elements coordinating developmental EDC gene expression as an unexplored resource for genetic variants in skin diseases. PMID:20089530

  7. [Encouraging healthy habits by playing with the child in the family milieu: the snakes and ladders game].

    PubMed

    Sánchez Echenique, M; Pèlach, R

    2002-01-01

    In recent decades society has been undergoing many changes and these have had a strong incidence on infant morbidity and mortality. Diseases that have practically vanished due to the impact of vaccinations and the improvement of the standard of living have given way to others derived from the changes in eating habits and life style; accidents, on the other hand, have come to be the first cause of morbidity and mortality after the first year of life has been passed. Strategies must be directed towards avoiding the causes of this new way of falling ill. We present a Spanish version of a game similar to "snakes and ladders" called "the healthy goose", which encourages healthy living habits. In order that the child should internalize safe habits by means of the game, certain squares in the game have been replaced by positive drawings, in which the child carries out healthy activities, receiving prizes for these, and others in which risky activities are performed, which are penalized. The areas dealt with are: habits (nutrition, sleep, study, games, etc.), Accidents at home, road safety (pedestrian, cyclist and automobile traveler), and swimming pools. The game starts with a child of 3-4 years and the goal is reached as a healthy adolescent. Given that the variation in personalities is enormous, we believe the family milieu should be the complement to legislative and educational measures and general campaigns in the means of communication, since it is what the child knows best and where he learns his deepest attitudes. This game could be a help to parents in this difficult task. PMID:12861260

  8. [Encouraging healthy habits by playing with the child in the family milieu: the snakes and ladders game].

    PubMed

    Sánchez Echenique, M; Pèlach, R

    2002-01-01

    In recent decades society has been undergoing many changes and these have had a strong incidence on infant morbidity and mortality. Diseases that have practically vanished due to the impact of vaccinations and the improvement of the standard of living have given way to others derived from the changes in eating habits and life style; accidents, on the other hand, have come to be the first cause of morbidity and mortality after the first year of life has been passed. Strategies must be directed towards avoiding the causes of this new way of falling ill. We present a Spanish version of a game similar to "snakes and ladders" called "the healthy goose", which encourages healthy living habits. In order that the child should internalize safe habits by means of the game, certain squares in the game have been replaced by positive drawings, in which the child carries out healthy activities, receiving prizes for these, and others in which risky activities are performed, which are penalized. The areas dealt with are: habits (nutrition, sleep, study, games, etc.), Accidents at home, road safety (pedestrian, cyclist and automobile traveler), and swimming pools. The game starts with a child of 3-4 years and the goal is reached as a healthy adolescent. Given that the variation in personalities is enormous, we believe the family milieu should be the complement to legislative and educational measures and general campaigns in the means of communication, since it is what the child knows best and where he learns his deepest attitudes. This game could be a help to parents in this difficult task.

  9. Key endothelial cell angiogenic mechanisms are stimulated by the circulating milieu in sickle cell disease and attenuated by hydroxyurea.

    PubMed

    Lopes, Flavia C M; Traina, Fabiola; Almeida, Camila B; Leonardo, Flavia C; Franco-Penteado, Carla F; Garrido, Vanessa T; Colella, Marina P; Soares, Raquel; Olalla-Saad, Sara T; Costa, Fernando F; Conran, Nicola

    2015-06-01

    As hypoxia-induced inflammatory angiogenesis may contribute to the manifestations of sickle cell disease, we compared the angiogenic molecular profiles of plasma from sickle cell disease individuals and correlated these with in vitro endothelial cell-mediated angiogenesis-stimulating activity and in vivo neovascularization. Bioplex demonstrated that plasma from patients with steady-state sickle cell anemia contained elevated concentrations of pro-angiogenic factors (angiopoietin-1, basic fibroblast growth factor, vascular endothelial growth factor, vascular endothelial growth factor-D and placental growth factor) and displayed potent pro-angiogenic activity, significantly increasing endothelial cell proliferation, migration and capillary-like structure formation. In vivo neovascularization of Matrigel plugs was significantly greater in sickle cell disease mice than in non-sickle cell disease mice, consistent with an up-regulation of angiogenesis in the disease. In plasma from patients with hemoglobin SC disease without proliferative retinopathy, anti-angiogenic endostatin and thrombospondin-2 were significantly elevated. In contrast, plasma from hemoglobin SC individuals with proliferative retinopathy had a pro-angiogenic profile and more significant effects on endothelial cell proliferation and capillary formation than plasma from patients without retinopathy. Hydroxyurea therapy was associated with significant reductions in plasma angiogenic factors and inhibition of endothelial cell-mediated angiogenic mechanisms and neovascularization. Thus, individuals with sickle cell anemia or hemoglobin SC disease with retinopathy present a highly angiogenic circulating milieu, capable of stimulating key endothelial cell-mediated angiogenic mechanisms. Combination anti-angiogenic therapy to prevent the progression of unregulated neovascularization and associated manifestations in sickle cell disease, such as pulmonary hypertension, may be indicated; furthermore, the

  10. Correlated and Anticorrelated Domain Movement of Human Serum Albumin: A Peek into the Complexity of the Crowded Milieu.

    PubMed

    Biswas, Saikat; Chowdhury, Pramit Kumar

    2016-06-01

    Protein dynamics in cells have been shown to be markedly different from that in dilute solutions because of the highly crowded cellular interior. The volume exclusion arising from the high concentration of macromolecules present can affect both equilibrium and kinetic processes involving protein conformational changes. While global changes in structure leading to modulations in the stability of the protein have been well-documented, local changes that can have a large bearing on the functional aspects of these biomolecules are rare to come across. Using the multidomain serum protein human serum albumin and a fluorescence resonance energy transfer (FRET)-based approach, with fluorescent reporters in each of its three domains, we, in this article, have provided a detailed mapping of variations in the interdomain distances (as a function of pH) in the presence of five macromolecular crowding agents, differing based on their constituent monomers and average molecular weight(s). From the observation of correlated domain movements for dextran based crowding agents to anticorrelated motion induced by Ficoll 70, and both correlated and anticorrelated action for PEG8000 (PEG8), our results reveal the inherent complexity of a crowded milieu with the serum protein serving as an able sensor for decoding such variations. Differences in the manner in which the macromolecular crowders of similar average molecular weights influence the protein conformational ensemble also provide insights into the possible variations at the molecular level that these polymeric molecules possess. Evidence is presented in support of the fact that for the large molecular weight crowding agents and PEG8, soft interactions predominate over hard sphere potentials. Finally, the nature of domain movements encountered for the serum protein are of immense significance with respect to the function of human serum albumin (HSA) as a prolific binder and transporter of small molecules. PMID:27163260

  11. Modelisation du Signal Radar EN Milieu Stratifie et Evaluation de Techniques de Mesure de L'humidite du Sol

    NASA Astrophysics Data System (ADS)

    Boisvert, Johanne

    La presente etude se penche sur des problemes relies a l'echantillonnage de l'humidite de sol et a l'estimation du signal radar sur sols nus. Le travail se divise en deux volets. Le volet 1 evalue trois techniques de mesure de l'humidite du sol (gravimetrie, reflectometrie temporelle et sonde dielectrique) et deux protocoles d'echantillonnage. Dans le volet 2, un modele de simulation du signal en milieu stratifie est developpe, et les estimes de signal obtenus sont compares aux estimes bases uniquement sur une valeur moyenne d'humidite du sol prise sur une profondeur fixe d'echantillonnage. Les differences entre les deux estimes dependent de la frequence et du choix judicieux de la profondeur d'echantillonnage; elles sont plus importantes aux faibles angles et en polarisation HV, puis VV. Le modele de simulation a aussi ete utilise pour etudier la profondeur de penetration du signal et en deduire la profondeur optimale d'echantillonnage en tenant compte des caracteristiques du signal. Une variation de 25 ^circ de l'angle d'incidence a peu d'effet sur la profondeur de penetration en bande Ku; l'ecart reste inferieur ou egal a 0,5 cm en bande C mais peut atteindre 1,3 cm en bande L. L'impact de la polarisation est nul en bande Ku mais croi t avec l'angle d'incidence en bande C et L. A 50^circ, il est, en moyenne de 1 cm en bande C et de 2 cm en bande L. En polarisation VV, la profondeur croi t avec une augmentation de l'angle alors que l'effet est inverse en polarisation HH. Deux methodes pour estimer la profondeur d'echantillonnage en conditions operationnelles sont presentees. Lorsqu'on inverse un modele pour estimer l'humidite du sol a partir du signal, ces methodes permettent aussi d'estimer l'epaisseur de sol representee par l'humidite ainsi estimee.

  12. Les tumeurs malignes anorectales en milieu hospitalier à Ouagadougou: aspects épidémiologiques et diagnostiques

    PubMed Central

    Guingané, Alice Nanelin; Sombié, Roger Arsène; Bougouma, Alain

    2014-01-01

    Le but de notre étude était de décrire les caractéristiques épidémiologiques et diagnostiques des tumeurs malignes anorectales en milieu hospitalier à Ouagadougou. Il s'est agi d'une étude rétrospective et transversale qui a concerné les patients vus en endoscopie digestive basse au cours de la période allant du 29/09/1999 au 04/10/2008. À l'aide d'une fiche de collecte, nous avons recueilli, dans 4 structures sanitaires et 3 laboratoires d'anatomie et de cytologie pathologiques de la ville de Ouagadougou, les données à partir des comptes-rendus d'endoscopie digestive basse et des registres d'anatomie et de cytologie pathologiques. Durant la période de notre étude, 645 patients ont été examinés en anorectoscopie et 882 cas d'affections anorectales colligés. Les tumeurs malignes anorectales avec 61 cas (6,9%) occupaient la quatrième place après la maladie hémorroïdaire (45,6%), les anites (21,1%) et les fissures (13,9%). Elles regroupaient les cancers du rectum (4,2%) et les cancers de l'anus (2,7%). Vingt cancers anorectaux ont été histologiquement confirmés parmi lesquels l'adénocarcinome était le type histologique le plus retrouvé avec 17 cas. Les tumeurs malignes, quatrième affection anorectale la plus fréquente au cours de notre étude, constituent une préoccupation du fait de leur fréquence croissante, leur diagnostic souvent tardif et les difficultés liées à leur prise en charge surtout dans nos pays avec une population à faible revenu. La sensibilisation de la population et la prescription plus large de l'endoscopie digestive basse devraient permettre une meilleure prise en charge des patients. PMID:25368715

  13. [Cosmos, coral and cultural milieu. The significance of the popular science connection in the late German Empire and the Weimar Republic].

    PubMed

    Schirrmacher, Arne

    2008-12-01

    This paper discusses the role of popular science communication for the 'cultural milieu' or more generally the 'environment' of scientists and science in Germany between c. 1900 and 1933 in the sense of Paul Forman. On the rich basis of diverse journals aiming at a differentiated public the discourse on atomic physics is sketched. Since the thesis of a general hostility towards atomic physics in particular and science in general cannot be accredited the question arises how widespread and in which sense a crisis of science was discussed in the Weimar years. PMID:19391361

  14. [Cosmos, coral and cultural milieu. The significance of the popular science connection in the late German Empire and the Weimar Republic].

    PubMed

    Schirrmacher, Arne

    2008-12-01

    This paper discusses the role of popular science communication for the 'cultural milieu' or more generally the 'environment' of scientists and science in Germany between c. 1900 and 1933 in the sense of Paul Forman. On the rich basis of diverse journals aiming at a differentiated public the discourse on atomic physics is sketched. Since the thesis of a general hostility towards atomic physics in particular and science in general cannot be accredited the question arises how widespread and in which sense a crisis of science was discussed in the Weimar years.

  15. Defected red blood cell membranes and direct correlation with the uraemic milieu: the connection with the decreased red blood cell lifespan observed in haemodialysis patients

    NASA Astrophysics Data System (ADS)

    Stamopoulos, D.; Grapsa, E.; Manios, E.; Gogola, V.; Bakirtzi, N.

    2012-12-01

    Together with impaired production of erythropoietin and iron deficiency, the decreased lifespan of red blood cells (RBCs) is a main factor contributing to the chronic anaemia observed in haemodialysis (HD) patients. Atomic force microscopy is employed in this work to thoroughly survey the membrane of intact RBCs (iRBCs) of HD patients in comparison to those of healthy donors, aiming to obtain direct information on the structural status of RBCs that can be related to their decreased lifespan. We observed that the iRBC membrane of the HD patients is overpopulated with extended circular defects, termed ‘orifices’, that have typical dimension ranging between 0.2 and 1.0 μm. The ‘orifice’ index—that is, the mean population of ‘orifices’ per top membrane surface—exhibits a pronounced relative increase of order 54 ± 12% for the HD patients as compared to healthy donors. Interestingly, for the HD patients, the ‘orifice’ index, which relates to the structural status of the RBC membrane, correlates strongly with urea concentration, which is a basic index of the uraemic milieu. Thus, these results indicate that the uraemic milieu downgrades the structural status of the RBC membrane, possibly triggering biochemical processes that result in their premature elimination from the circulation. This process could decrease the lifespan of RBCs, as observed in HD patients.

  16. Approche aux soins en milieu communautaire à des adultes ayant une déficience développementale

    PubMed Central

    Osmun, W.E.; Chan, Nelson; Solomon, Robert

    2015-01-01

    Résumé Objectif Passer en revue les obligations d’ordre médical, éthique et juridique dans les soins aux adultes ayant une déficience développementale (DD) qui vivent dans la communauté. Sources des données Des recherches ont été faites dans Google et MEDLINE à l’aide des mots disabled, disability, vulnerable et community. Les lois pertinentes ont fait l’objet d’un examen. Message principal Le traitement d’un patient ayant une DD varie en fonction de facteurs comme la pathogenèse du problème actuel du patient, ses affections concomitantes, la gravité de ses déficiences et ses soutiens sociaux habituels. Bien que l’on s’entende sur les bienfaits du transfert des soins institutionnels vers des soins communautaires pour les patients ayant une DD, il s’est révélé difficile de leur dispenser des soins de grande qualité en milieu communautaire. Par ailleurs, il existe peu de travaux de recherche sur les façons d’offrir efficacement des soins aux adultes ayant une DD. En tant que professionnels des soins primaires, les médecins de famille sont souvent le premier point de contact pour les patients et sont à la fois responsables de la coordination et de la continuité des soins. Compte tenu de l’importance accrue accordée aux soins préventifs et à la détection précoce des maladies, la participation active du patient revêt aussi une grande importance. Les valeurs et les objectifs du patient sont des éléments essentiels à prendre en compte, même s’ils vont à l’encontre de la bonne santé du patient ou des propres valeurs du clinicien. Les lois s’appliquant aux personnes vulnérables varient d’une province à l’autre. Par conséquent, l’obligation de signaler des mauvais traitements suspectés pourrait différer selon que la personne vulnérable habite dans un centre de soins ou la communauté, que la personne qui soupçonne le comportement abusif est un fournisseur de services ou un professionnel de la santé ou

  17. The "kidney-liver" multiorgan ex vivo perfused model improves the circuit's biochemical milieu during perfusion compared to the "liver-kidney" counterpart.

    PubMed

    Chung, Wen Yuan; Gravante, Gianpiero; Eltweri, Amar; Sorge, Roberto; Ong, Seok Ling; Pollard, Cristina; Metcalfe, Mathew; Dennison, Ashley

    2015-06-01

    The multiorgan ex vivo perfused liver-kidney model allows studying the hepatic pathophysiology and purifying waste products. We tested if the addition of the kidney first followed by the liver (KL circuit) produces better results compared to the classic liver-first approach (LK). Intact livers and kidneys were obtained post mortem from ten female domestic white pigs, five experiments were conducted with the KL circuit and five with the LK. Bile, urine production, arterial blood gases, glucose, renal and liver tests were collected hourly during the perfusions. The KL circuit had values more close to physiological ranges, more stable over time and showed less variability compared to the LK circuit for urine production, glucose, PH, anion gap, lactate, urea, sodium, potassium and Alanine Transaminase (ANOVA test for repeated measures p < 0.05). The KL circuit produced a more physiological and reliable biochemical milieu.

  18. Integration des sciences et de la langue: Creation et experimentation d'un modele pedagogique pour ameliorer l'apprentissage des sciences en milieu francophone minoritaire

    NASA Astrophysics Data System (ADS)

    Cormier, Marianne

    Les faibles resultats en sciences des eleves du milieu francophone minoritaire, lors d'epreuves au plan national et international, ont interpelle la recherche de solutions. Cette these avait pour but de creer et d'experimenter un modele pedagogique pour l'enseignement des sciences en milieu linguistique minoritaire. En raison de la presence de divers degres de francite chez la clientele scolaire de ce milieu, plusieurs elements langagiers (l'ecriture, la discussion et la lecture) ont ete integres a l'apprentissage scientifique. Nous avions recommande de commencer le processus d'apprentissage avec des elements langagiers plutot informels (redaction dans un journal, discussions en dyades...) pour progresser vers des activites langagieres plus formelles (redaction de rapports ou d'explications scientifiques). En ce qui a trait a l'apprentissage scientifique, le modele preconisait une demarche d'evolution conceptuelle d'inspiration socio-constructiviste tout en s'appuyant fortement sur l'apprentissage experientiel. Lors de l'experimentation du modele, nous voulions savoir si celui-ci provoquait une evolution conceptuelle chez les eleves, et si, simultanement, le vocabulaire scientifique de ces derniers s'enrichissait. Par ailleurs, nous cherchions a comprendre comment les eleves vivaient leurs apprentissages dans le cadre de ce modele pedagogique. Une classe de cinquieme annee de l'ecole de Grande-Digue, dans le Sud-est du Nouveau-Brunswick, a participe a la mise a l'essai du modele en etudiant les marais sales locaux. Lors d'entrevues initiales, nous avons remarque que les connaissances des eleves au sujet des marais sales etaient limitees. En effet, s'ils etaient conscients que les marais etaient des lieux naturels, ils ne pouvaient pas necessairement les decrire avec precision. Nous avons egalement constate que les eleves utilisaient surtout des mots communs (plantes, oiseaux, insectes) pour decrire le marais. Les resultats obtenus indiquent que les eleves ont

  19. A Qualitative Analysis of Substance Use among Liberian Youth: Understanding Behaviors, Consequences, and Protective Factors Involving School Youth and the School Milieu

    PubMed Central

    Pullen, Samuel J; Petruzzi, Liana; Lange, Brittany CL; Parnarouskis, Lindsey; Dominguez, Silvia; Harris, Benjamin; Quiterio, Nicole; Durham, Michelle P; Lekpeh, Gondah; Manobah, Burgess; Slopadoe, Siede P; Diandy, Veronique C; Payne, Arthur J; Henderson, David C; Borba, Christina PC

    2016-01-01

    Objective Substance use is a significant and common problem among school-aged youths throughout Africa. Like other countries on this continent, the West-African nation of Liberia is recovering from civil war. A well-educated population of young people is critical to the recovery efforts and long-term success of Liberia. Substance use by school-aged youths has important public health consequences that could undermine Liberia’s post-conflict recovery efforts. We wanted to better understand the culturally significant themes and subthemes related to substance use among youths attending public schools in Monrovia, Liberia. Methods A qualitative research design was used to collect data from 72 students attending public school in Monrovia, Liberia. Nine focus groups of 6–8 students from three public schools were facilitated using a semi-structured format to guide discussions on substance use. Student narratives were translated and re-occurring themes and subthemes were coded and analyzed. Results Four emergent themes described in this study were: Behaviors associated with substance use Consequences associated with individual use Consequences of substance use that affected the school milieu School-related factors that were protective from substance use. Subthemes associated with substance use included concealment of substances, intoxication and disruption of the classroom environment, expulsion from school, school drop-out, and school as protective against substance use. Conclusion Liberian school-aged youths described important themes and subthemes associated with substance use occurring within the school milieu. These data have germane public health ramifications, and could help inform larger epidemiologic study methods and public health interventions for Liberia and countries with similar profiles. PMID:27158680

  20. MMP1-1607 polymorphism increases the risk for periapical lesion development through the upregulation MMP-1 expression in association with pro-inflammatory milieu elements

    PubMed Central

    TROMBONE, Ana Paula Favaro; CAVALLA, Franco; SILVEIRA, Elcia Maria Varize; ANDREO, Camile Bermejo; FRANCISCONI, Carolina Favaro; FONSECA, Angélica Cristina; LETRA, Ariadne; SILVA, Renato Menezes; GARLET, Gustavo Pompermaier

    2016-01-01

    ABSTRACT Increased matrix metalloproteinases (MMPs) activity is a hallmark of periapical granulomas. However, the factors underlying the MMPs expression modulation in healthy and diseased periapical tissues remains to be determined. Objective In this study, we evaluated the association between the MMP1-1607 polymorphism (rs1799750) and pro-inflammatory milieu elements with MMP-1 mRNA levels in vivo. Material and Methods MMP1-1607 SNP and the mRNA levels of MMP-1, TNF-a, IFN-g, IL-17A, IL-21, IL-10, IL-4, IL-9, and FOXp3 were determined via RealTimePCR in DNA/RNA samples from patients presenting periapical granulomas (N=111, for both genotyping and expression analysis) and control subjects (N=214 for genotyping and N=26 for expression analysis). The Shapiro-Wilk, Fisher, Pearson, Chi-square ordinal least squares regression tests were used for data analysis (p<0.05 was considered statistically significant). Results The MMP1-1607 1G/2G and 1G/2G+2G/2G genotypes were significantly more prevalent in the patients than in controls, comprising a risk factor for periapical lesions development. MMP-1 mRNA levels were higher in periapical lesions than in healthy periodontal ligament samples, as well as higher in active than in inactive lesions. The polymorphic allele 2G carriers presented a significantly higher MMP-1 mRNA expression when compared with the 1G/1G genotype group. The ordered logistic regression demonstrated a significant correlation between the genetic polymorphism and the expression levels of MMP-1. Additionally, the pro- and anti-inflammatory cytokines IL-17A, IFN-g, TNF-a, IL-21, IL-10, IL-9, and IL-4 were significant as complementary explanatory variables of MMP-1 expression. Conclusion The MMP1-1607 SNP was identified as a risk factor for periapical lesions development, possibly due to its association with increased MMP-1 mRNA levels in periapical lesions. The MMP-1 expression is also under the control of the inflammatory milieu elements, being the

  1. Prévalence des cervicalgies et douleurs des membres supérieures chez les utilisateurs d'ordinateur en milieu professionnel à Casablanca (Maroc)

    PubMed Central

    Seknaji, Nawal; Rachidi, Wafaa; Hassoune, Samira; Janani, Saadia; Nani, Samira; Maaroufi, Abderrahmane; Mkinsi, Ouafaa

    2013-01-01

    Introduction Les cervicalgies et douleurs du membre supérieur (CDMS) affectent des millions d'utilisateurs d'ordinateurs dans les pays développés. L'objectif de ce travail était de déterminer la prévalence des cervicalgies et douleurs du membre supérieur (CDMS) à Casablanca et identifier les différents facteurs de risque qui y sont impliqués, afin de définir les sous-groupes à haut risque, et d’établir des plans d'intervention efficaces. Méthodes Il s'agit d'une étude transversale, menée chez 118 employés de bureau francophones et utilisant l'ordinateur, à Casablanca. Les données ont été collectées de Décembre 2011 à Juin 2012, en utilisant la version française d'un questionnaire validé: Maastricht-Upper-extremity-Questionnaire. Résultats 118 utilisateurs d'ordinateur en milieu professionnel ont été recrutés. Parmi les employés enquêtés, 93% ont rapporté des CDMS localisées au moins à un site. Les plaintes les plus fréquemment rapportées étaient les douleurs des épaules et les cervicalgies (48,3% et 46,6% respectivement). Nous n'avons pas remarqué de différence significative des fréquences des douleurs selon le genre. Nos résultats concordent avec les données de la littérature où il existe un certain consensus quant à l'impact des mauvaises conditions ergonomiques sur les troubles musculo-squelettiques du membre supérieur en milieu professionnel. De même, les études récentes examinant les effets combinés et/ou interactifs tant des facteurs biomécaniques/physiques que de facteurs psychosociaux professionnels vont de pair avec nos résultats. Conclusion Il en ressort que les stratégies d'intervention visant à réduire les CDMS doivent agir essentiellement sur 3 volets, le premier correspond à l'amélioration et la sensibilisation quant au respect des conditions ergonomiques, le second concerne l'amélioration des conditions psychosociales. Enfin le troisième volet vise la rationalisant de la demande de

  2. A grid matrix-based Raman spectroscopic method to characterize different cell milieu in biopsied axillary sentinel lymph nodes of breast cancer patients.

    PubMed

    Som, Dipasree; Tak, Megha; Setia, Mohit; Patil, Asawari; Sengupta, Amit; Chilakapati, C Murali Krishna; Srivastava, Anurag; Parmar, Vani; Nair, Nita; Sarin, Rajiv; Badwe, R

    2016-01-01

    Raman spectroscopy which is based upon inelastic scattering of photons has a potential to emerge as a noninvasive bedside in vivo or ex vivo molecular diagnostic tool. There is a need to improve the sensitivity and predictability of Raman spectroscopy. We developed a grid matrix-based tissue mapping protocol to acquire cellular-specific spectra that also involved digital microscopy for localizing malignant and lymphocytic cells in sentinel lymph node biopsy sample. Biosignals acquired from specific cellular milieu were subjected to an advanced supervised analytical method, i.e., cross-correlation and peak-to-peak ratio in addition to PCA and PC-LDA. We observed decreased spectral intensity as well as shift in the spectral peaks of amides and lipid bands in the completely metastatic (cancer cells) lymph nodes with high cellular density. Spectral library of normal lymphocytes and metastatic cancer cells created using the cellular specific mapping technique can be utilized to create an automated smart diagnostic tool for bench side screening of sampled lymph nodes. Spectral library of normal lymphocytes and metastatic cancer cells created using the cellular specific mapping technique can be utilized to develop an automated smart diagnostic tool for bench side screening of sampled lymph nodes supported by ongoing global research in developing better technology and signal and big data processing algorithms.

  3. Interstitial fluid flow within bone canaliculi and electro-chemo-mechanical features of the canalicular milieu: a multi-parametric sensitivity analysis.

    PubMed

    Sansalone, Vittorio; Kaiser, Joanna; Naili, Salah; Lemaire, Thibault

    2013-06-01

    Canalicular fluid flow is acknowledged to play a major role in bone functioning, allowing bone cells' metabolism and activity and providing an efficient way for cell-to-cell communication. Bone canaliculi are small canals running through the bone solid matrix, hosting osteocyte's dendrites, and saturated by an interstitial fluid rich in ions. Because of the small size of these canals (few hundred nanometers in diameter), fluid flow is coupled with electrochemical phenomena. In our previous works, we developed a multi-scale model accounting for coupled hydraulic and chemical transport in the canalicular network. Unfortunately, most of the physical and geometrical information required by the model is hardly accessible by nowadays experimental techniques. The goal of this study was to numerically assess the influence of the physical and material parameters involved in the canalicular fluid flow. The focus was set on the electro-chemo-mechanical features of the canalicular milieu, hopefully covering any in vivo scenario. Two main results were obtained. First, the most relevant parameters affecting the canalicular fluid flow were identified and their effects quantified. Second, these findings were given a larger scope to cover also scenarios not considered in this study. Therefore, this study gives insight into the potential interactions between electrochemistry and mechanics in bone and provides the rational for further theoretical and experimental investigations.

  4. A grid matrix-based Raman spectroscopic method to characterize different cell milieu in biopsied axillary sentinel lymph nodes of breast cancer patients.

    PubMed

    Som, Dipasree; Tak, Megha; Setia, Mohit; Patil, Asawari; Sengupta, Amit; Chilakapati, C Murali Krishna; Srivastava, Anurag; Parmar, Vani; Nair, Nita; Sarin, Rajiv; Badwe, R

    2016-01-01

    Raman spectroscopy which is based upon inelastic scattering of photons has a potential to emerge as a noninvasive bedside in vivo or ex vivo molecular diagnostic tool. There is a need to improve the sensitivity and predictability of Raman spectroscopy. We developed a grid matrix-based tissue mapping protocol to acquire cellular-specific spectra that also involved digital microscopy for localizing malignant and lymphocytic cells in sentinel lymph node biopsy sample. Biosignals acquired from specific cellular milieu were subjected to an advanced supervised analytical method, i.e., cross-correlation and peak-to-peak ratio in addition to PCA and PC-LDA. We observed decreased spectral intensity as well as shift in the spectral peaks of amides and lipid bands in the completely metastatic (cancer cells) lymph nodes with high cellular density. Spectral library of normal lymphocytes and metastatic cancer cells created using the cellular specific mapping technique can be utilized to create an automated smart diagnostic tool for bench side screening of sampled lymph nodes. Spectral library of normal lymphocytes and metastatic cancer cells created using the cellular specific mapping technique can be utilized to develop an automated smart diagnostic tool for bench side screening of sampled lymph nodes supported by ongoing global research in developing better technology and signal and big data processing algorithms. PMID:26552923

  5. Does Cattle Milieu Provide a Potential Point to Target Wild Exophilic Anopheles arabiensis (Diptera: Culicidae) with Entomopathogenic Fungus? A Bioinsecticide Zooprophylaxis Strategy for Vector Control

    PubMed Central

    Lyimo, Issa N.; Ng'habi, Kija R.; Mpingwa, Monica W.; Daraja, Ally A.; Mwasheshe, Dickson D.; Nchimbi, Nuru S.; Lwetoijera, Dickson W.; Mnyone, Ladslaus L.

    2012-01-01

    Background. Anopheles arabiensis is increasingly dominating malaria transmission in Africa. The exophagy in mosquitoes threatens the effectiveness of indoor vector control strategies. This study aimed to evaluate the effectiveness of fungus against An. arabiensis when applied on cattle and their environments. Methods. Experiments were conducted under semi-field and small-scale field conditions within Kilombero valley. The semi-field reared females of 5–7 days old An. arabiensis were exposed to fungus-treated and untreated calf. Further, wild An. arabiensis were exposed to fungus-treated calves, mud-huts, and their controls. Mosquitoes were recaptured the next morning and proportion fed, infected, and survived were evaluated. Experiments were replicated three times using different individuals of calves. Results. A high proportion of An. arabiensis was fed on calves (>0.90) and become infected (0.94) while resting on fungus-treated mud walls than on other surfaces. However, fungus treatments reduced fecundity and survival of mosquitoes. Conclusion. This study demonstrates for the first time the potential of cattle and their milieu for controlling An. arabiensis. Most of An. arabiensis were fed and infected while resting on fungus-treated mud walls than on other surfaces. Fungus treatments reduced fecundity and survival of mosquitoes. These results suggest deployment of bioinsecticide zooprophylaxis against exophilic An. arabiensis. PMID:22934152

  6. Extracerebellar progenitors grafted to the neurogenic milieu of the postnatal rat cerebellum adapt to the host environment but fail to acquire cerebellar identities.

    PubMed

    Rolando, Chiara; Gribaudo, Simona; Yoshikawa, Kazuaki; Leto, Ketty; De Marchis, Silvia; Rossi, Ferdinando

    2010-04-01

    Stem or progenitor cells acquire specific regional identities during early ontogenesis. Nonetheless, there is evidence that cells heterotopically transplanted to neurogenic regions of the developing or mature central nervous system may switch their fate to adopt host-specific phenotypes. Here, we isolated progenitor cells from different germinative sites along the neuraxis where GABAergic interneurons are produced (telencephalic subventricular zone, medial ganglionic eminence, ventral mesencephalon and dorsal spinal cord), and grafted them to the prospective white matter of the postnatal rat cerebellum, at the time when local interneurons are generated. The phenotype acquired by transplanted cells was assessed by different criteria, including expression of region-specific transcription factors, acquisition of morphological and neurochemical traits, and integration in the cerebellar cytoarchitecture. Regardless of their origin, all the different types of donor cells engrafted in the cerebellar parenchyma and developed mature neurons that shared some morphological and neurochemical features with local inhibitory interneurons, particularly in the deep nuclei. Nevertheless, transplanted cells failed to activate cerebellar-specific regulatory genes. In addition, their major structural features, the expression profiles of type-specific markers and the laminar placement in the recipient cortex did not match those of endogenous interneurons generated during the same developmental period. Therefore, although exogenous cells are influenced by the cerebellar milieu and show remarkable capabilities for adapting to the foreign environment, they essentially fail to switch their fate, integrate in the host neurogenic mechanisms and adopt clear-cut cerebellar identities.

  7. Uncovering the biochemical milieu of myofascial trigger points using in vivo microdialysis: an application of muscle pain concepts to myofascial pain syndrome.

    PubMed

    Shah, Jay P; Gilliams, Elizabeth A

    2008-10-01

    This article discusses muscle pain concepts in the context of myofascial pain syndrome (MPS) and summarizes microdialysis studies that have surveyed the biochemical basis of this musculoskeletal pain condition. Though MPS is a common type of non-articular pain, its pathophysiology is only beginning to be understood due to its enormous complexity. MPS is characterized by the presence of myofascial trigger points (MTrPs), which are defined as hyperirritable nodules located within a taut band of skeletal muscle. MTrPs may be active (spontaneously painful and symptomatic) or latent (non-spontaneously painful). Painful MTrPs activate muscle nociceptors that, upon sustained noxious stimulation, initiate motor and sensory changes in the peripheral and central nervous systems. This process is called sensitization. In order to investigate the peripheral factors that influence the sensitization process, a microdialysis technique was developed to quantitatively measure the biochemical milieu of skeletal muscle. Biochemical differences were found between active and latent MTrPs, as well as in comparison with healthy muscle tissue. In this paper we relate the findings of elevated levels of sensitizing substances within painful muscle to the current theoretical framework of muscle pain and MTrP development.

  8. Acid gradient across plasma membrane can drive phosphate bond synthesis in cancer cells: acidic tumor milieu as a potential energy source.

    PubMed

    Dhar, Gautam; Sen, Suvajit; Chaudhuri, Gautam

    2015-01-01

    Aggressive cancers exhibit an efficient conversion of high amounts of glucose to lactate accompanied by acid secretion, a phenomenon popularly known as the Warburg effect. The acidic microenvironment and the alkaline cytosol create a proton-gradient (acid gradient) across the plasma membrane that represents proton-motive energy. Increasing experimental data from physiological relevant models suggest that acid gradient stimulates tumor proliferation, and can also support its energy needs. However, direct biochemical evidence linking extracellular acid gradient to generation of intracellular ATP are missing. In this work, we demonstrate that cancer cells can synthesize significant amounts of phosphate-bonds from phosphate in response to acid gradient across plasma membrane. The noted phenomenon exists in absence of glycolysis and mitochondrial ATP synthesis, and is unique to cancer. Biochemical assays using viable cancer cells, and purified plasma membrane vesicles utilizing radioactive phosphate, confirmed phosphate-bond synthesis from free phosphate (Pi), and also localization of this activity to the plasma membrane. In addition to ATP, predominant formation of pyrophosphate (PPi) from Pi was also observed when plasma membrane vesicles from cancer cells were subjected to trans-membrane acid gradient. Cancer cytosols were found capable of converting PPi to ATP, and also stimulate ATP synthesis from Pi from the vesicles. Acid gradient created through glucose metabolism by cancer cells, as observed in tumors, also proved critical for phosphate-bond synthesis. In brief, these observations reveal a role of acidic tumor milieu as a potential energy source and may offer a novel therapeutic target.

  9. Potentiel des images satellitaires multibandes a haute resolution spatiale pour la cartographie des componsants de l'eau en milieu cotier marin

    NASA Astrophysics Data System (ADS)

    Lavoie, Andre

    L'objectif principal que que nous poursuivons est de developper un modele de simulation du transfert radiatif eau-atmosphere adapte aux observations faites par le capteur Thematic Mapper (TM) de Landsat. Les informations que nous cherchons ont trait au milieu cotier marin et concernent les elements qui sont en suspension dans l'eau. Les images multibandes du capteur TM dans la partie visible du spectre, sont surtout visees par nos travaux. A la base de la simulation, nous utilisons un programme de simulation atmospherique, le code 6S, auquel nous greffons un modele de simulation du transfert radiatif dans la masse d'eau. Ce dernier estime le signal en fonction de 4 composants: l'eau, les pigments chlorophylliens (chlorophylle et phaeopigments), les matieres minerales et les substances organiques dissoutes. La concentration des differents composants sert de parametre d'entree pour definir le comportement optique de la masse d'eau. Le modele permet egalement de simuler une masse d'eau stratifiee si l'on connai t les concentrations des composants dans les differentes couches. Il inclut aussi la contribution du fond, selon sa nature et sa composition, ainsi que celle du miroitement du soleil et du ciel a la surface de l'eau. Les informations d'un echantillonnage de la masse d' eau synchronise avec le passage du satellite, a la baie des Chaleurs, d'une cartographie du couvert d'algues et d'un modele bathymetrique ont ete utilisees pour fixer les parametres de simulation par le modele. La comparaison montrent que le modele se comporte relativement bien surtout dans la bande TM2. Une erreur systematique de 2 valeurs numeriques en moyenne subsiste dans les trois bandes spectrales. Les resultats nous montrent que la visibilite du fond aux faibles profondeurs est un element tres important a considerer. Par ailleurs, l'analyse de sensibilite montre que les images TM sont plus sensibles aux concentrations en matieres minerales qu'aux pigments chlorophylliens et aux substances

  10. Anatomical localization of the effects of reproductive state, castration, and social milieu on cells immunoreactive for gonadotropin-releasing hormone-I in male European starlings (Sturnus vulgaris).

    PubMed

    Stevenson, Tyler J; Ball, Gregory F

    2009-11-10

    Gonadotropin-releasing hormone-I (GnRH-I) cells are localized primarily to the septopreoptic area (POA) and are responsible for regulating gonadotropin release from the anterior pituitary. Some songbird species exhibit dramatic seasonal variation in the number of detectable GnRH-I immunoreactive cells, with higher numbers being observed during the breeding season. Here we investigated the anatomical distribution of GnRH-I-immunoreactive cells in male starlings that varied in response to manipulations of reproductive state, social context, and gonadal condition. We housed photostimulated, intact and castrated male starlings with a female or alone. Additionally, a fifth treatment group consisted of photorefractory males (i.e., in a nonreproductive state) housed alone. All photostimulated males had significantly greater numbers of GnRH-I cells compared with photorefractory male starlings. There was a significant main effect of castration and social context. Castrated males had significantly greater numbers of GnRH-I cells compared with intact males, and males housed in male-female dyads also had greater numbers of GnRH-I cells. Furthermore, the significant main effects of castration and social context were the result of an increase in GnRH-I cell numbers specifically in the rostral and intermediate regions of the POA. These findings indicate that social context and hormonal milieu have profound effects on GnRH-I immunoreactivity in addition to the previously described effects of reproductive state. These data provide novel insight into the environmental regulation of the hypothalamopituitary axis and suggest that gonadal hormones and female presence independently regulate GnRH-I cells in specific regions of the POA in male starlings. PMID:19731303

  11. Proteomics of the periconception milieu.

    PubMed

    Fazeli, Alireza; Moein Vaziri, Najmeh; Holt, William Vincent

    2015-02-01

    There is increasing realisation that human health status in adulthood depends critically upon environmental conditions pertaining around the time of conception and during pregnancy. Poor maternal diet or adverse environmental conditions around the periconception period somehow induces the resultant embryo to adapt predictively in order to survive this level of stress for the whole of its life. However, if there is a mismatch between expectation and reality, where the conditions during later life are better than expected, things go wrong and the adult suffers a range of illnesses, including diabetes, heart disease, hypertension and stroke. Understanding the molecular signals that direct the early embryo to adopt appropriate adaptations to suit its future life would be extremely valuable. However, although it appears to be an ideal task for proteomic applications, there are technical, ethical and practical limitations to what can be achieved with the current framework of proteomic technology. Here, we review what has been achieved to date, explain some of the experimental problems and suggest some strategies for taking this field forward.

  12. EPR-Spin Trapping and Flow Cytometric Studies of Free Radicals Generated Using Cold Atmospheric Argon Plasma and X-Ray Irradiation in Aqueous Solutions and Intracellular Milieu.

    PubMed

    Uchiyama, Hidefumi; Zhao, Qing-Li; Hassan, Mariame Ali; Andocs, Gabor; Nojima, Nobuyuki; Takeda, Keigo; Ishikawa, Kenji; Hori, Masaru; Kondo, Takashi

    2015-01-01

    intracellular milieu is discussed.

  13. Diabète en milieu urbain de Ouagadougou au Burkina Faso: profil épidémiologique et niveau de perception de la population adulte

    PubMed Central

    Millogo, Georges Rosario Christian; Yaméogo, Clément; Samandoulougou, André; Yaméogo, Nobila Valentin; Kologo, Koudougou Jonas; Toguyeni, Jean Yves; Zabsonré, Patrice

    2015-01-01

    Introduction L'accroissement rapide de la prévalence du diabète sucré en Afrique subsaharienne constitue un problème de santé public. L'Organisation Mondiale de la Santé (OMS) estime qu’à l'horizon 2025, l'augmentation la plus significative de la prévalence du diabète sera enregistrée dans les pays en développement. Ceux-ci devraient abriter 75% des patients diabétiques du monde. Outre ses complications métaboliques, le diabète est un facteur de risque cardiovasculaire majeur. Le but de notre étude était de decrire le profil épidémiologique du diabète et d’évaluer le niveau de perception de la maladie par une population africaine en milieu urb qwqain de Ouagadougou. Méthodes Le diabète a été défini chez tout sujet ayant une glycémie casuelle supérieure à 2 g/L ou une glycémie à jeun supérieur ou égale à 1,26 g/L (≥ 7 mmol/L) à deux controles d'une semaine d'intervalle. Etaient considérés diabétique, les sujets déjà suivis et ceux nouvellement dépistés par l'etude. Résultats L’étude a inclus 1532 personnes, d’âge compris entre 25 et 64 ans dont 55,6% d'hommes et 44,4% de femmes. L’âge moyen était 36,10 ± 11,19 ans. La tranche d’âge de 25 à 34 ans était la plus représentée avec une proportion de 57,1%. La glycémie moyenne était de 1,04 g/L, la proportion des femmes ayant une hyperglycémie était statistiquement plus importante que celle des hommes (p< 0,05). Près de 81,3% de la population ignoraient que le diabète était un facteur de risque cardiovasculaire. Conclusion Il est urgent de mettre en place un programme national de lutte contre le diabète sucré et les autres maladies non transmissibles au Burkina Faso. PMID:26524982

  14. Signes cliniques rencontrés chez l'enfant malnutri dans un milieu minier: cas de la ville de Lubumbashi et ses environs

    PubMed Central

    Musimwa, Aimée Mudekereza; Kanteng, Gray Wakamb; Kitoko, Hermann Tamubango; Luboya, Oscar Numbi

    2016-01-01

    Introduction La malnutrition reste à ce jour un problème majeur de santé publique, notamment dans les pays en voie de développement. Cette étude a eu pour objectif de déterminer les signes cliniques observés chez l'enfant mal nourri, admis dans une unité de prise en charge. Méthodes Il s'agit d'une étude descriptive transversale, effectuée de juillet 2013 à décembre 2014. 311 cas ont été colligés (182 malnutris et 129 biens nourris), par échantillonnage exhaustif, avec un dépistage actif des enfants malnutris et biens nourris. Le diagnostic est fait cliniquement associé à l'anthropométrie. Résultats Les signes les plus enregistrés chez les enfants malnutris étaient dominés par la toux ou pneumopathie dans 42,50%, la gastroentérite dans 38,55%, les lésions dermatologiques ont présenté 22,91% de cas, la fièvre dans 22,35% de cas, 19,0% des enfants ont présenté les œdèmes, 8,38% d'enfants ont présenté la pâleur, enfin hépatomégalie et splénomégalie sont les signes les moins fréquents avec respectivement 1,68% et 2,89%. Tandis que les enfants en bonne état nutritionnel ont présenté plus la splénomégalie et la fièvre qui seraient liés au paludisme. Conclusion Les enfants malnutris vivant dans un milieu minier présentent une symptomatologie qui ne pas différents de autres enfants mal nourris à l'exception de l'hépatomégalie et splénomégalie qui sont très rare chez nos mal nourris. PMID:27642407

  15. EPR-Spin Trapping and Flow Cytometric Studies of Free Radicals Generated Using Cold Atmospheric Argon Plasma and X-Ray Irradiation in Aqueous Solutions and Intracellular Milieu

    PubMed Central

    Uchiyama, Hidefumi; Zhao, Qing-Li; Hassan, Mariame Ali; Andocs, Gabor; Nojima, Nobuyuki; Takeda, Keigo; Ishikawa, Kenji; Hori, Masaru; Kondo, Takashi

    2015-01-01

    intracellular milieu is discussed. PMID:26318000

  16. Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets?

    PubMed

    Welsh, Nils; Cnop, Miriam; Kharroubi, Ilham; Bugliani, Marco; Lupi, Roberto; Marchetti, Piero; Eizirik, Décio L

    2005-11-01

    Different degrees of beta-cell failure and apoptosis are present in type 1 and type 2 diabetes. It has been recently suggested that high glucose-induced beta-cell apoptosis in type 2 diabetes shares a final common pathway with type 1 diabetes, involving interleukin-1beta (IL-1beta) production by beta-cells, nuclear factor-kappaB (NF-kappaB) activation, and death via Fas-FasL. The aim of this study was to test whether human islet exposure to high glucose in vitro, or to the type 2 diabetes environment in vivo, induces IL-1beta expression and consequent activation of NF-kappaB-dependent genes. Human islets were isolated from five normoglycemic organ donors. The islets were cultured for 48 h to 7 days at 5.6, 11, or 28 mmol/l glucose. For comparative purposes, islets were also exposed to IL-1beta. Gene mRNA expression levels were assessed by real-time RT-PCR in a blinded fashion. Culture of the human islets at 11 and 28 mmol/l glucose induced a four- to fivefold increase in medium insulin as compared with 5.6 mmol/l glucose, but neither IL-1beta nor IL-1 receptor antagonist (IL-1ra) expression changed. IL-1beta and IL-1ra protein release to the medium was also unchanged. Stimulated human monocytes, studied in parallel, released >50-fold more IL-1beta than the islets. There was also no glucose-induced islet Fas expression. Expression of the NF-kappaB-dependent genes IkappaB-alpha and monocyte chemoattractant protein (MCP)-1 was induced in human islets by IL-1beta but not by high glucose. In a second set of experiments, human islets were isolated from seven type 2 diabetic patients and eight control subjects. The findings on mRNA levels were essentially the same as in the in vitro experiments, namely the in vivo diabetic state did not induce IL-1beta, Fas, or MCP-1 expression in human islets, and also did not modify IL-1ra expression. The present findings suggest that high glucose in vitro, or the diabetic milieu in vivo, does not induce IL-1beta production or NF

  17. Électrooxydation du mésoérythritol sur platine, modifié ou non par des adatomes, en milieu acide

    NASA Astrophysics Data System (ADS)

    Cherqaoui, A.; Chbihi, M. El M.; Takky, D.; Kokoh, K. B.; Leger, J.-M.; Lamy, C.

    1999-03-01

    The electrocatalytic oxidation of meso-erythritol has been studied in 0.1 M HClO4 on platinum and on adatoms modified platinum. Preliminary investigations by cyclic voltammetry showed that erythritol was not reactive on a Pt electrode. Underpotential deposition of lead or thallium adatoms at platinum allowed to increase significantly the current densities. Long-time electrolyses were carried out using a three potential plateau program with different values of the oxidation potentials. Chromatographic analyses showed that the oxidation of erythritol led mainly to erythrose, erythrulose and to erythronic acid. Otherwise, electrolysis of erythritol on a Pt-Tl modified electrode orientated selectively the distribution of the reaction products towards the formation of erythrulose. L'oxydation électrocatalytique du mésoérythrytol a été étudiée en milieu acide HClO4 0,1 M sur le platine modifié ou non par des adatomes métalliques. Les études préliminaires réalisées par voltammétrie cyclique montrent que l'érythritol est très peu réactif sur le platine seul. La modification de la surface de l'électrode par dépôt en sous-tension d'adatomes de plomb et de thallium permet d'augmenter les densités de courant. Les électrolyses prolongées sont réalisées à l'aide d'un programme à trois paliers de potentiel et pour différentes valeurs de potentiel d'oxydation. Les analyses chromatographiques montrent que les produits d'oxydation sont l'érythrose, l'érythrulose et l'acide érythronique. D'autre part l'oxydation de l'érythritol sur le platine modifié par des adatomes de thallium conduit à une production sélective d'érythrulose.

  18. Facteurs de risque de faible poids de naissance en milieu semi-rural de Kamina, République Démocratique du Congo

    PubMed Central

    Kangulu, Ignace Bwana; Umba, Elie Kilolo Ngoy; Nzaji, Michel Kabamba; Kayamba, Prosper Kalenga Mwenze

    2014-01-01

    Introduction Le faible poids de naissance constitue un problème majeur de santé publique, aussi bien dans les pays développés que dans les pays en développement, de par son ampleur et sa forte association avec la morbidité et la mortalité infantiles. Méthodes Il s’agit d’une étude cas-témoins rétrospective menée sur les différents facteurs de risque de faible poids de naissance(FPN) en milieu semi-rural de Kamina chez les accouchées et leurs nouveau-nés respectifs enregistrés de la période allant de janvier 2009 à décembre 2010. Résultats Cette étude a répertorié 69 cas des nouveau-nés de FPN sur 483 accouchements enregistrés (14,3%). Les facteurs associés au FPN déterminés dans ce travail sont l’âge maternel inférieur à 18 ans (OR=7,62, IC=3.46-16.8) et supérieur à 35 ans (OR=2,04;IC=0.91-4.46), la primiparité(OR=2,48;IC=1.18-5.21) et le non suivi des consultations prénatales (OR=5,50;IC=2.00-15.03), la prématurité avec grossesse âgée de moins de 37 semaines d’aménorrhée, la grossesse multiple (OR=30,94) et le sexe féminin du nouveau-né. Conclusion Cette étude a démontré que l’âge maternel inférieur à 18 ans et supérieur à 35 ans, le non suivi des consultations prénatales, la primiparité et la prématurité, la grossesse multiple et le sexe féminin du nouveau-né sont les facteurs associés au faible poids de naissance. PMID:25237417

  19. S100A8 and S100A9 are messengers in the crosstalk between epidermis and dermis modulating a psoriatic milieu in human skin

    SciTech Connect

    Lee, Young; Jang, Sunhyae; Min, Jeong-Ki; Lee, Kyungmin; Sohn, Kyung-Cheol; Lim, Jong-Soon; Im, Myung; Lee, Hae-Eul; Seo, Young-Joon; Kim, Chang-Deok; Lee, Jeung-Hoon

    2012-07-13

    Highlights: Black-Right-Pointing-Pointer Upregulated S100A8 and/or S100A9 in psoriasis epidermis induce cytokine production. Black-Right-Pointing-Pointer Upregulated S100A8 and/or S100A9 in psoriasis epidermis induce migration of immune cells. Black-Right-Pointing-Pointer Upregulated S100A8 and/or S100A9 in psoriasis epidermis induce angiogenesis. Black-Right-Pointing-Pointer S100A8 and/or S100A9 may play a role in the crosstalk between epidermis and dermis in psoriasis. -- Abstract: S100A8 and S100A9 are members of the S100A8 protein family that exist as homodimers and heterodimers in neutrophils, monocytes, and macrophages. Recent studies have shown the pivotal roles of S100A8 and S100A9 in the propagation of inflammation and keratinocyte proliferation in psoriasis. We found significant up-regulation of S100A8 and S100A9 secretion from keratinocytes in psoriatic lesions. To mimic the in vivo secretory conditions of S100A8 and S100A9 from psoriatic epidermal keratinocytes, we used the culture medium (CM) of S100A8 and S100A8/A9 adenovirus-transduced keratinocytes to investigate the functions of S100A8 and S100A9. We detected increased levels of various pro-inflammatory cytokines in the CM, including IL-8 and TNF-{alpha}, which are involved in aggravating psoriatic skin lesions, and IL-6 and members of the CXCL family of pro-angiogenic cytokines. The CM increased immune cell migration and increased angiogenesis in human umbilical vein endothelial cells. In conclusion, we found that the upregulated production of S100A8 and S100A9 by psoriatic epidermal keratinocytes activated adjacent keratinocytes to produce several cytokines. Moreover, S100A8 and S100A9 themselves function as pro-angiogenic and chemotactic factors, generating a psoriatic milieu in skin.

  20. EPR-Spin Trapping and Flow Cytometric Studies of Free Radicals Generated Using Cold Atmospheric Argon Plasma and X-Ray Irradiation in Aqueous Solutions and Intracellular Milieu.

    PubMed

    Uchiyama, Hidefumi; Zhao, Qing-Li; Hassan, Mariame Ali; Andocs, Gabor; Nojima, Nobuyuki; Takeda, Keigo; Ishikawa, Kenji; Hori, Masaru; Kondo, Takashi

    2015-01-01

    intracellular milieu is discussed. PMID:26318000

  1. Effets de la taille finie du milieu non-linéaire sur le bruit quantique spatial généré par un oscillateur paramétrique optique confocal

    NASA Astrophysics Data System (ADS)

    Lopez, L.; Gatti, A.; Maitre, A.; Treps, N.; Gigan, S.; Fabre, C.

    2004-11-01

    Nous nous intéressons au comportement spatial des fluctuations quantiques à la sortie d'un oscillateur paramétrique optique dégénéré en modes transverses, sous le seuil. En vue de futures expériences, nous étudions les effets de la diffraction dans le milieu paramétrique sur le bruit quantique spatial. Nous montrons que l'on voit apparaître une aire de cohérence de taille finie pour les effets quantiques transverses.

  2. Education and postgraduate education of psychiatrists in the Soviet Union and their integration into a new milieu. A view from the present to the past of former Soviet psychiatrists.

    PubMed

    Lerner, Vladimir; Frolova, Katherine; Witztum, Eliezer

    2007-01-01

    The article presents the problems and difficulties that psychiatrists from the former Soviet Union (FSU) have to cope with in Israel. Immigration and acculturation in a new milieu is a complex process and even more complicated for those whose specialty is medicine and particularly psychiatry. There is a wide gap between the skills and knowledge that new immigrants brought with them from the FSU and the professional demands in the new country. Psychiatry and psychiatric education in the FSU were determined by the cultural practices and traditions of the region and the organizational principles of the USSR which were very different than those of western society and the State of Israel. In comparison to the West, postgraduate psychiatric training in the USSR was shorter and less rigorous with an emphasis on biological therapy. Soviet "psychotherapy" was more reality oriented and more authoritarian than in the West, stressing "collective" group therapy. We describe the basic principles of Soviet medical education and the radically different social, intellectual and political history of the former Soviet Union. We relate the experiences of psychiatrists in the FSU in learning dynamic psychotherapy and the difficulties connected with this education. Moreover, the process of educating psychiatric residents is described from a supervisor's point of view. This complex process led to some major difficulties. In order to cope with the difficulties the supervisor employed a broad variety of means and techniques: an introductory course and a basic seminar about fundamental cornerstones of psychotherapy were offered.

  3. Analysis of a cultural consensus model of two good-life sub-domains--health & well-being and migration & socioeconomic milieu--in three population groups in Croatia.

    PubMed

    Peternel, Lana; Malnar, Ana; Klarić, Irena Martinović

    2015-07-01

    In this study the construct of a 'good life' was explored among upper secondary school senior pupils and their parents and teachers by applying cultural consensus model analysis. A total of 469 students, 474 parents and 158 teachers from four Croatian cities participated in the study, which was conducted in 2011/2012. The information collected through interviewing and free-listing during the first phase of the study was used to create a set of structured questionnaire questions as a part of the survey in the second phase of data collection. The results are reported on two good-life sub-domains: 'health & well-being' and 'migration & socioeconomic milieu'. The results indicate heterogeneity of the sample groups, incomplete inter-generational transmission of cultural values and examples of two sub-groups that resist cultural norms and do not comply with the dominant 'competence-as-sharing' paradigm. The value of testing the cultural consensus model based on the emic approach and locally significant phenomena is demonstrated for planning and conducting holistic anthropological research.

  4. [Psychoanalytic psychotherapy in a hospital milieu].

    PubMed

    Reid, W

    1981-10-01

    Using a clinical case, I have attempted to demonstrate how an analytic "listening attitude" may permit a patient request which would at a manifest level, not usually require insight but, if such were given, would then influence the whole course of treatment. Thus, the fundamental concept of psychoanalysis dealing with unconscious mental mechanisms becomes operational if it is not limited simply to a technical frame of reference. The developing situation then approaches that of psychoanalysis. This process may occur if flexibility is maintained in the basic technique of psychotherapy. The views of Jean Bergeret on borderline states are briefly presented as tools of psychodynamic understanding of clinical situations. PMID:7296459

  5. The Changing Milieu for Educational Planning.

    ERIC Educational Resources Information Center

    Keller, George

    1995-01-01

    Three major demographic trends (immigration patterns, dissolution of the traditional family structure, and the emerging age profile of the United States population) and three social trends (socioeconomic polarization, growing importance of the Pacific Rim countries to American trade, and new communications technology) are examined as they affect…

  6. [The interpreter in an intercultural clinical milieu].

    PubMed

    Vissandjée, B; Ntetu, A L; Courville, F; Breton, E R; Bourdeau, M

    1998-05-01

    The public's diversified language profile means that nursing practice must adjust to provide the same quality of care to all clients, no matter what language they speak. To improve quality and quantity of information exchanged in the nurse-client-interpreter triangle, the authors have investigated the type of information likely to be filtered and studied the various factors underlying the interpreter's choice to filter information. The authors also analyzed the values interpreters assign to information and the factors that form the background for filtering, including mistrust. The authors suggest adequately preparing interpreters; using interpreters' expertise; and developing an appropriate training program for intercultural interpreters to enable them to better function within health care institutions. PMID:9923211

  7. Does the uremic milieu affect the epigenotype?

    PubMed

    Stenvinkel, Peter; Ekström, Tomas J

    2009-01-01

    Epigenetics is a discipline that for many years has languished in the shadow of its genomic big brother. Because our understanding of the role played by epigenetics in chronic kidney disease remains in its infancy, further studies are needed to understand the associations, for instance, of aberrant DNA methylation in relation to uremic dysmetabolism, and its presumably very complex interactions in the development of premature uremic vascular disease. Further research is also needed to study the association between aberrant global DNA-methylation, gene-level methylation status, and the silencing (or activation) of candidate genes associated with atherosclerosis. Insofar as it seems possible to manipulate the epigenome, the effects of various epigenetic-targeted and pathway-targeted therapeutic approaches on unbalanced DNA methylation, gene silencing, and vascular health and outcomes should be explored further in uremia.

  8. Temptation and Seduction in the Technological Milieu

    ERIC Educational Resources Information Center

    van der Laan, J. M.

    2004-01-01

    Jacques Ellul's work on propaganda provides the basis for this analysis of life in technology. Advertising and the mass media rely on temptation and seduction and create a constant flow of propaganda, all of which serve the technological system. Propaganda aims to condition and regulate us so that we participate in and adapt ourselves to a desired…

  9. Étude par détection de photons des processus électroniques au sein d'une jonction tunnel dans un milieu moléculaire

    NASA Astrophysics Data System (ADS)

    Perronet, K.

    2005-03-01

    Analysis of the luminescence induced by a STM (scanning tunneling microscope) permits to get insights into the electronic processes taking place in a single nanoscopic tunnel junction. We studied a Au(111)/Au junction under vacuum (UHV) and immersed in a molecular medium. The study under UHV reveals the influence of spatial variations of surface local density of states (LDOS) on the luminescence. The emission at the solid-liquid interface is characterized and the role played by the dielectric function is shown. Time correlations between the emitted single photons are then studied. Depending on the liquid immersing the junction, a photon bunching can occur. We link this bunching with structural changes of the junction induced by the presence of a diffusing molecule. If the HOMO LUMO gap of the molecule is small enough, resonant tunnelling paths exist and tunnelling-electron bunching occurs. Finally, the influence of a self-assembled monolayer on the substrate is investigated. Boundings between triphenylene derivatives and Au(111) are too weak, but with chemisorbed alcanethiols, molecular resolution is reached both on the STM image and on the photon map. We show that the contrast on photon map comes from the modulation of the LDOS spatial extension into the barrier due to the S Au bond. The elaboration of organic multilayers is considered as a route for observing the electroluminescence of a single molecule, isolated from the substrate by thiols and to study correlations of electronic origin. We have already optically characterised such a layer using C{60}. La luminescence induite par STM (microscopie à effet tunnel) est une source d'informations d'une grande richesse sur les processus électroniques au sein d'un objet nanoscopique individuel. Nous nous sommes intéressés à une jonction Au/Au(111) sous vide puis dans un milieu moléculaire. L'étude sous vide a permis de montrer l'influence des variations spatiales des densités d'états de la surface. L

  10. The Roosevelt years: crucial milieu for Carl Rogers' innovation.

    PubMed

    Barrett-Lennard, Godfrey T

    2012-02-01

    This study explores broad features of political culture and event of the 1930s and World War 2 years, viewed in relation to the emergence and rapid early growth of the new therapy of Carl Rogers. The paper traces Rogers' early professional life and examines distinctive emphases in sociopolitical thought and development during Franklin D. Roosevelt's leadership as President over the prolonged emergency of the Great Depression and the crisis of the War. The study includes a focus on the President's own outlook and style, pertinent New Deal innovations, and wartime needs. Twelve features of this larger context are discriminated as together having vital importance for the new therapy and its founder. The congruent courses of the macrocontext and of Rogers' innovation are followed to the ending of Roosevelt's life. Direct causation is not attributed, but the evidence adduced newly points to particular contours of a larger environment favorable for the expression of Rogers' values and rare ability. In sum, the author concludes that a synergy of highly conducive historical circumstance and individual exceptionality contributed to the philosophical underpinnings, attitudinal values and early momentum of Rogers' client-centered therapy.

  11. Antipsychotic effect of milieu in the acute treatment of schizophrenia.

    PubMed

    Cohen, S; Khan, A

    1990-07-01

    We studied 35 patients meeting DSM-III criteria for schizophrenia, paranoid or undifferentiated type, chronic with acute exacerbation. All were treated in hospital, 13 on a psychiatric intensive care unit, and 22 on an open ward. The former unit is a more structured and less stimulating one. We found those patients treated on that ward to show greater improvement in BPRS ratings during the first 2 days of hospitalization compared to the open-ward group, despite similar doses of medication being utilized. Additionally, this improvement was noted to occur among BPRS items comprising a psychotic subscale.

  12. Communiquer en milieu interculturel (Communicating in an Intercultural Environment).

    ERIC Educational Resources Information Center

    Yanaprasart, Patchareerat, Ed.

    2002-01-01

    The articles, written in French, in this issue refer to research and intercultural practices with regard to confrontational situations between two or more cultural systems. The titles are as follows: "La culture universitaire comme culture en soi" (The University Culture as a Culture in Its Own Right) (Aline Gohard-Radenkovic); "Interrelations…

  13. Telemedicine: socio-ethical considerations in the Indian milieu.

    PubMed

    Sharma, Luv K; Rajput, Meena

    2009-01-01

    Telemedicine is the rapidly developing application of clinical medicine by telephone, the internet or other networks for the purpose of consulting, and on occasions carrying out examinations or medical procedures. Telemedicine may be as simple as two health professionals discussing a case over the telephone, or as complex as using satellite technology and video-conferencing equipment to conduct a real-time consultation between medical specialists in two different countries. Telemedicine offers real benefits in a country as vast as India where the majority of the population lives in remote areas with no access to even the most basic healthcare. As the practice of telemedicine spreads, maintaining standards, security and privacy, will be a challenge especially with regard to legal and regulatory measures and who will be held responsible if telemedicine-assisted surgery fails due to failure in connectivity? Is it the surgeon, the satellite provider or the software/hardware engineer? What is the legal status of telemedicine-based diagnosis and treatment? Other legal issues involve conflicting national laws and information piracy, the dangers of prescription drugs that are banned in one country but not in another and quacks who offer medical advice and prescribe drugs over the internet. This paper discusses some of the legal, ethical and social considerations in the Indian context. PMID:19731480

  14. New Frontiers: "Milieu" and the Sociology of American Jewish Education

    ERIC Educational Resources Information Center

    Horowitz, Bethamie

    2008-01-01

    Over the course of the twentieth century changing circumstances have prompted American Jewish educators to develop new educational strategies to address these needs, and these developments are an important aspect of the sociology of American Jewish education. Using the method of historical sociology, I examine the educational configuration at…

  15. Top 10 milieu interventions for inpatient child/adolescent treatment.

    PubMed

    Delaney, Kathleen R

    2006-11-01

    Presented in this article are 10 interventions to deal with children and adolescents on inpatient psychiatric units. The 10 are divided into three categories: behavioral, cognitive, and affective. The interventions discussed are particularly relevant to staff in their efforts to help children and adolescents achieve control over their thoughts, feelings, and behaviors. Each intervention includes a summary of the theory that supports its efficacy, a brief explanation of the intervention, and methods for applying the technique in clinical situations.

  16. Chronic Glucocorticoid-Rich Milieu and Liver Dysfunction

    PubMed Central

    Castro, María Cecilia

    2016-01-01

    We investigated the impact of chronic hypercorticosteronemia (due to neonatal monosodium L-glutamate, MSG, and treatment) on liver oxidative stress (OS), inflammation, and carbohydrate/lipid metabolism in adult male rats. We evaluated the peripheral concentrations of several metabolic and OS markers and insulin resistance indexes. In liver we assessed (a) OS (GSH and protein carbonyl groups) and inflammatory (IL-1b, TNFa, and PAI-1) biomarkers and (b) carbohydrate and lipid metabolisms. MSG rats displayed degenerated optic nerves, hypophagia, low body and liver weights, and enlarged adipose tissue mass; higher peripheral levels of glucose, triglycerides, insulin, uric acid, leptin, corticosterone, transaminases and TBARS, and peripheral and liver insulin resistance; elevated liver OS, inflammation markers, and glucokinase (mRNA/activity) and fructokinase (mRNA). Additionally, MSG liver phosphofructokinase-2, glucose-6-phosphatase (mRNA and activity) and glucose-6-phosphate dehydrogenase, Chrebp, Srebp1c, fatty acid synthase, and glycerol-3-phosphate (mRNAs) were increased. In conclusion adult MSG rats developed an insulin-resistant state and increased OS and serious hepatic dysfunction characterized by inflammation and metabolic signs suggesting increased lipogenesis. These features, shared by both metabolic and Cushing's syndrome human phenotypes, support that a chronic glucocorticoid-rich endogenous environment mainly impacts on hepatic glucose cycle, displacing local metabolism to lipogenesis. Whether correcting the glucocorticoid-rich environment ameliorates such dysfunctions requires further investigation.

  17. Creating a Critical Literacy Milieu in a Kindergarten Classroom

    ERIC Educational Resources Information Center

    Stribling, Stacia M.

    2014-01-01

    The purpose of this study was to better understand the process of engaging in critical literacy practices with kindergarteners. The researcher spent six months in a kindergarten classroom taking extensive field notes on the ways in which the teacher and students explored issues of social justice through literacy activities. Data analysis using a…

  18. Teaching Your Tot to Talk: Using Milieu Teaching Strategies

    ERIC Educational Resources Information Center

    Curiel, Emily S. L.; Sainato, Diane M.

    2016-01-01

    Both of these toddlers struggle with communication. Parents and practitioners working with very young children often struggle to find ways to enhance their toddlers' communication skills. They may question: When do I teach? What should I teach? Where do I teach? How do I teach? This article will provide suggestions and techniques to support the…

  19. Chronic Glucocorticoid-Rich Milieu and Liver Dysfunction

    PubMed Central

    Castro, María Cecilia

    2016-01-01

    We investigated the impact of chronic hypercorticosteronemia (due to neonatal monosodium L-glutamate, MSG, and treatment) on liver oxidative stress (OS), inflammation, and carbohydrate/lipid metabolism in adult male rats. We evaluated the peripheral concentrations of several metabolic and OS markers and insulin resistance indexes. In liver we assessed (a) OS (GSH and protein carbonyl groups) and inflammatory (IL-1b, TNFa, and PAI-1) biomarkers and (b) carbohydrate and lipid metabolisms. MSG rats displayed degenerated optic nerves, hypophagia, low body and liver weights, and enlarged adipose tissue mass; higher peripheral levels of glucose, triglycerides, insulin, uric acid, leptin, corticosterone, transaminases and TBARS, and peripheral and liver insulin resistance; elevated liver OS, inflammation markers, and glucokinase (mRNA/activity) and fructokinase (mRNA). Additionally, MSG liver phosphofructokinase-2, glucose-6-phosphatase (mRNA and activity) and glucose-6-phosphate dehydrogenase, Chrebp, Srebp1c, fatty acid synthase, and glycerol-3-phosphate (mRNAs) were increased. In conclusion adult MSG rats developed an insulin-resistant state and increased OS and serious hepatic dysfunction characterized by inflammation and metabolic signs suggesting increased lipogenesis. These features, shared by both metabolic and Cushing's syndrome human phenotypes, support that a chronic glucocorticoid-rich endogenous environment mainly impacts on hepatic glucose cycle, displacing local metabolism to lipogenesis. Whether correcting the glucocorticoid-rich environment ameliorates such dysfunctions requires further investigation. PMID:27597864

  20. Striding Toward Social Justice: The Ecologic Milieu of Physical Activity

    PubMed Central

    Lee, Rebecca E.; Cubbin, Catherine

    2009-01-01

    Disparities in physical activity should be investigated in light of social justice principles. This manuscript critically evaluates evidence and trends in disparities research within an ecologic framework, focusing on multi-level factors such as neighborhood and racial discrimination that influence physical activity. Discussion focuses on strategies for integrating social justice into physical activity promotion and intervention programming within an ecologic framework. PMID:19098519

  1. Photodynamic Therapy: The Imminent Milieu For Treating Oral Lesions

    PubMed Central

    Mohanty, Neeta; Jalaluddin, MD; Kotina, Sreekanth; Routray, Samapika; Ingale, Yashwant

    2013-01-01

    Photodynamic therapy (PDT) is used in curative and palliative treatment of head and neck squamous cell carcinoma (HNSCC) and other oral lesions. Oral infections (such as mucosal and endodontic infections, periodontal diseases, caries, and peri-implantitis) are among the specific targets where PDT can be applied Photodynamic therapy (PDT) efficacy depends on the local dose deposited in the lesion as well as oxygen availability in the lesion. Further long-term clinical studies are necessary in establishing a more specific place of the technique in the field of dentistry. PMID:23905154

  2. Chronic Glucocorticoid-Rich Milieu and Liver Dysfunction.

    PubMed

    Villagarcía, Hernán Gonzalo; Sabugo, Vanesa; Castro, María Cecilia; Schinella, Guillermo; Castrogiovanni, Daniel; Spinedi, Eduardo; Massa, María Laura; Francini, Flavio

    2016-01-01

    We investigated the impact of chronic hypercorticosteronemia (due to neonatal monosodium L-glutamate, MSG, and treatment) on liver oxidative stress (OS), inflammation, and carbohydrate/lipid metabolism in adult male rats. We evaluated the peripheral concentrations of several metabolic and OS markers and insulin resistance indexes. In liver we assessed (a) OS (GSH and protein carbonyl groups) and inflammatory (IL-1b, TNFa, and PAI-1) biomarkers and (b) carbohydrate and lipid metabolisms. MSG rats displayed degenerated optic nerves, hypophagia, low body and liver weights, and enlarged adipose tissue mass; higher peripheral levels of glucose, triglycerides, insulin, uric acid, leptin, corticosterone, transaminases and TBARS, and peripheral and liver insulin resistance; elevated liver OS, inflammation markers, and glucokinase (mRNA/activity) and fructokinase (mRNA). Additionally, MSG liver phosphofructokinase-2, glucose-6-phosphatase (mRNA and activity) and glucose-6-phosphate dehydrogenase, Chrebp, Srebp1c, fatty acid synthase, and glycerol-3-phosphate (mRNAs) were increased. In conclusion adult MSG rats developed an insulin-resistant state and increased OS and serious hepatic dysfunction characterized by inflammation and metabolic signs suggesting increased lipogenesis. These features, shared by both metabolic and Cushing's syndrome human phenotypes, support that a chronic glucocorticoid-rich endogenous environment mainly impacts on hepatic glucose cycle, displacing local metabolism to lipogenesis. Whether correcting the glucocorticoid-rich environment ameliorates such dysfunctions requires further investigation. PMID:27597864

  3. Literacy in a Non-Literacy Milieu: The Indian Scenario.

    ERIC Educational Resources Information Center

    Saraf, S. N.

    Section 1 of this report develops the thesis that while illiteracy is deeply entrenched in certain areas of India, it is also confined to specific pockets of the population. Recognition of this fact should be the basis, according to the author, of literacy strategy. Section 2 provides a history of the levels of priority given to adult education…

  4. Le pompage optique naturel dans le milieu astrophysique

    NASA Astrophysics Data System (ADS)

    Pecker, J.-C.

    The title of this lecture abstracts only a part of it : the importance in astrophysics of the study of non-LTE situations has become considerable, as well in the stellar atmospheres as, still more, in the study of fortuitous coincidences as a mechanism of formation of emission line nebular spectra, or of molecular interstellar « masers ». Another part of this talk underlines the role of Kastler in his time, and describes his warm personality through his public reactions in front of the nuclear armement, of the Viet-Nam and Algerian wars, of the problems of political refugees... Kastler was a great scientist ; he was also a courageous humanist. 1976 : Les accords nucléaires du Brésil : allocution d'ouverture (19 mars). Colloque sur le sujet ci-dessus. 1976 : La promotion de la culture dans le nouvel ordre économique international, allocution à l'occasion d'une table ronde sur ce thème par l'UNESCO (23-27 juin 1976) ; « Sciences et Techniques », octobre 1976. 1979 : La bête immonde (avec J.-C. Pecker), « Le Matin », 20 mars. 1979 : Appel à nos ministres (avec J.-C. Pecker), « Le Monde », 13 décembre. 1979 : Le flou, le ténébreux, l'irrationnel (avec J.-C. Pecker), « Le Monde », 14 septembre. 1980 : Education à la paix, Préface, in : Publ. UNESCO. 1981 : Le vrai danger, « Le Monde », 6 août 1981. 1982 : Nucléaire civil et militaire, « Le Monde », 1er juin 1982. 1982 : Les scientifiques face à la perspective d'holocauste nucléaire (texte inédit). Le titre de cette communication en résume seulement une partie : l'importance prise en astrophysique par l'analyse des situations hors ETL est devenue considérable, qu'il s'agisse des atmosphères stellaires, ou plus encore, des coïncidences fortuites de la formation des spectres d'émission nébulaires, ou des « masers » moléculaires interstellaires. Une autre partie de cet exposé souligne le rôle de Kastler dans son époque, et décrit sa personnalité généreuse à travers ses réactions publiques face à l'armement nucléaire, aux guerres de Viet-Nam et d'Algérie, aux problèmes des réfugiés politiques... Kastler était un grand savant, mais aussi un homme courageux.

  5. The Roosevelt years: crucial milieu for Carl Rogers' innovation.

    PubMed

    Barrett-Lennard, Godfrey T

    2012-02-01

    This study explores broad features of political culture and event of the 1930s and World War 2 years, viewed in relation to the emergence and rapid early growth of the new therapy of Carl Rogers. The paper traces Rogers' early professional life and examines distinctive emphases in sociopolitical thought and development during Franklin D. Roosevelt's leadership as President over the prolonged emergency of the Great Depression and the crisis of the War. The study includes a focus on the President's own outlook and style, pertinent New Deal innovations, and wartime needs. Twelve features of this larger context are discriminated as together having vital importance for the new therapy and its founder. The congruent courses of the macrocontext and of Rogers' innovation are followed to the ending of Roosevelt's life. Direct causation is not attributed, but the evidence adduced newly points to particular contours of a larger environment favorable for the expression of Rogers' values and rare ability. In sum, the author concludes that a synergy of highly conducive historical circumstance and individual exceptionality contributed to the philosophical underpinnings, attitudinal values and early momentum of Rogers' client-centered therapy. PMID:22530376

  6. Langage, normes et repertoire en milieu urbain africain: L'indoubill (Language, Norms, and Repertoire in the African Urban Milieu: Indoubill).

    ERIC Educational Resources Information Center

    Sesep, N'Sial Bal-Nsien

    A study explored, from a sociolinguistic perspective, the phenomenon of indoubill, patterns and usage of a special variety of Lingala, among a group of delinquent urban youth in Kinshasa (Zaire). It is proposed that: (1) at a particular moment in its social history, the community experienced sociocultural change that brought with it a special…

  7. The milieu of managerial work: an integrative framework linking work context to role requirements.

    PubMed

    Dierdorff, Erich C; Rubin, Robert S; Morgeson, Frederick P

    2009-07-01

    Theoretical and empirical efforts focusing on the interplay between work context and managerial role requirements have been conspicuously absent in the scholarly literature. This paucity exists despite over 60 years of research concerning the requirements of managerial work and with the rather universal recognition that work context meaningfully shapes organizational behavior. The authors developed a theoretical model linking different types of role requirements to different forms of work context. They empirically tested this framework with a nationally representative sample of 8,633 incumbent spanning 52 managerial occupations. Findings from hierarchical linear modeling analyses demonstrated that discrete forms of context (task, social, and physical) exert significant and predictable effects on managerial role requirements.

  8. Ionic milieu of bovine and ovine rumen as affected by diet.

    PubMed

    Bennink, M R; Tyler, T R; Ward, G M; Johnson, D E

    1978-03-01

    Postprandial changes in osmolality, mineral, and volatile fatty acid concentrations in rumen fluid were examined in three cattle fed six widely differing diets. Mineral concentrations varied with diet and postprandial time. However, net changes in postprandial mineral concentrations did not contribute significantly to changes in osmotic pressure. There was an effect of diet and time after feeding on concentrations of volatile fatty acids. Postprandial changes in osmotic pressure were primarily due to changes in concentrations of volatile fatty acids. Magnesium oxide and sodium bicarbonate were fed to sheep to increase the osmotic pressure in rumen fluid. The salt supplement decreased acetate, propionate, heat, and methane production. However, rumen water flux was unaffected by the salt supplementation. Diets which produce hypertonic rumen fluid due to high mineral and/or concentrations of volatile fatty acids may reduce fermentation in rumen.

  9. Faculty Pedagogical Approach, Skill, and Motivation in Today's Distance Education Milieu.

    ERIC Educational Resources Information Center

    Crumpacker, Norman

    2001-01-01

    This literature reviews explores the pedagogical approach, skills, and motivation factors that influence or are influenced by distance education instructors. Discusses Asynchronous Learning Networks (ALNs), a collaborative, problem-based asynchronous course design; and the need for instructor training and development to improve skills needed that…

  10. [Environmental somatization syndrome. How to deal with the external milieu syndrome?].

    PubMed

    Nilsson, C G; Göthe, C J; Molin, C

    1994-01-01

    Somatization is a tendency to experience and communicate psychogenic distress in the form of somatic symptoms and to seek medical help for them. Patients suffering from environmental somatization syndrome (ESS) consider their symptoms to be caused by exposure to chemical or physical components of the external environment or by ergonomic stress at work. ESS is distinguished by mental contagiousness and a tendency to cluster. Sometimes it explodes in wide-spread epidemics that may be escalated by mass-media campaigns. Extensive ESS epidemics have been connected to, i.a., arsenic, carbon monoxide ("generator gas poisoning"), mercury ("oral galvanism"), carbon-free copy papers, electromagnetic fields ("electric allergy") and repetitive movements ("repetition strain injury", RSI). The typical patient directs the interest on the external environment, refuses alternative explanations of his symptoms and abhors any suggestion of a psychogenic etiology. The community is often placed in difficult positions by lobby groups calling for drastic measures to eliminate alleged disease-inducing exposures. When hygienic evils occur simultaneously with an ESS epidemic, it is essential to strictly differ the hygienic problems from the ESS problems. If mismanaged, measures aimed at reducing hygienic inconveniences may aggravate the complex of ESS problems.

  11. Effects of dietary inclusion of Rhus coriaria on internal milieu of rabbits.

    PubMed

    Capcarova, M; Slamecka, J; Abbas, K; Kolesarova, A; Kalafova, A; Valent, M; Filipejova, T; Chrastinova, L; Ondruska, L; Massanyi, P

    2012-06-01

    The aim of the present work was to investigate the effect of Rhus coriaria L. inclusion to the diet on some biochemical, haematological parameters and the level of antioxidant status of male rabbits. Adult rabbits were divided into five groups: one control (C) and four experimental groups. Experimental animals received sumac per os in feed in various doses (0.50%, 0.75%, 1.00% and 1.50%) for 90 days. Significant increase in PDWc (platelet distribution width) in E3 group when compared with control group was recorded. Sumac administration resulted in decreased cholesterol levels in all experimental groups vs. control group. Significantly lower level of cholesterol was found in E4 group with highest dose of sumac (1.50%). Higher values of total antioxidant status (TAS) and albumins were observed in all experimental groups in comparison with control group. A significant increase in TAS was detected in group E1 and E4. Concentrations of albumins were significantly higher in groups E3 and E4 vs. control group. Sumac administration had no significant effect on bilirubin content. In conclusion, these results show a positive effect of sumac consumption on antioxidant status and cholesterol level in adult male rabbits. PMID:21585564

  12. Bone Marrow Stem/Progenitor Cells Attenuate the Inflammatory Milieu Following Substitution Urethroplasty

    PubMed Central

    Liu, Joceline S.; Bury, Matthew I.; Fuller, Natalie J.; Sturm, Renea M.; Ahmad, Nida; Sharma, Arun K.

    2016-01-01

    Substitution urethroplasty for the treatment of male stricture disease is often accompanied by subsequent tissue fibrosis and secondary stricture formation. Patients with pre-existing morbidities are often at increased risk of urethral stricture recurrence brought upon in-part by delayed vascularization accompanied by overactive inflammatory responses following surgery. Within the context of this study, we demonstrate the functional utility of a cell/scaffold composite graft comprised of human bone marrow-derived mesenchymal stem cells (MSC) combined with CD34+ hematopoietic stem/progenitor cells (HSPC) to modulate inflammation and wound healing in a rodent model of substitution urethroplasty. Composite grafts demonstrated potent anti-inflammatory effects with regards to tissue macrophage and neutrophil density following urethral tissue analyses. This was accompanied by a significant reduction in pro-inflammatory cytokines TNFα and IL-1β and further resulted in an earlier transition to tissue remodeling and maturation with a shift in collagen type III to I. Grafted animals demonstrated a progressive maturation and increase in vessel size compared to control animals. Overall, MSC/CD34+ HSPC composite grafts reduce inflammation, enhance an earlier transition to wound remodeling and maturation concurrently increasing neovascularization in the periurethral tissue. We demonstrate the feasibility and efficacy of a stem cell-seeded synthetic graft in a rodent substitution urethroplasty model. PMID:27762304

  13. Learning Experiences of Gifted Young String Players in the Taiwan Milieu

    ERIC Educational Resources Information Center

    Liu, Chia-Hui

    2008-01-01

    The purpose of this study was to investigate the development of the learning experiences of gifted young string players in Taiwan. Nine musicians under the age of 40, who had been accepted into music programs for the gifted, were invited to discuss their experiences and the development of their careers. Thorough interviews were conducted and then…

  14. Student Teachers' General and Content-Specific Pedagogical Development within a Mathematics Milieu

    ERIC Educational Resources Information Center

    Piccolo, Diana L.; Capraro, Mary Margaret; Capraro, Robert M.

    2010-01-01

    Fourteen elementary and 6 middle level student teachers were observed and interviewed throughout their initial field placement teaching experience. The Classroom Observation and Performance Assessment for Teachers-Revised (COPAT-R) observation instrument and semistructured interviews were used to compare general and content-specific pedagogical…

  15. Increasing Social Interaction Using Prelinguistic Milieu Teaching with Nonverbal School-Age Children with Autism

    ERIC Educational Resources Information Center

    Franco, Jessica H.; Davis, Barbara L.; Davis, John L.

    2013-01-01

    Purpose: Children with autism display marked deficits in initiating and maintaining social interaction. Intervention using play routines can create a framework for developing and maintaining social interaction between these children and their communication partners. Method: Six nonverbal 5- to 8-year-olds with autism were taught to engage in…

  16. Increasing Math Milieu Teaching by Varying Levels of Consultation Support: An Example of Analyzing Intervention Strength

    ERIC Educational Resources Information Center

    Marsicano, Richard T.; Morrison, Julie Q.; Moomaw, Sally C.; Fite, Nathan M.; Kluesener, Courtney M.

    2015-01-01

    The current study used a single-case design to examine two performance feedback conditions varying in intensity on the frequency of naturalistic math instruction in preschool classrooms during non-instructional times (transition, lunch, free play). Three Head Start teachers received professional development that combined information on four…

  17. The Antikythera Mechanism: The oldest mechanical universe in its scientific milieu

    NASA Astrophysics Data System (ADS)

    Moussas, Xenophon

    2011-06-01

    In this review the oldest known advanced astronomical instrument and dedicated analogue computer is presented, in context. The Antikythera Mechanism a mysterious device, assumed to be ahead of its time, probably made around 150 to 100 BCE, has been found in a 1st century BCE shipwreck near the island of Antikythera in a huge ship full of Greek treasures that were on their way to Rome. The Antikythera Mechanism is a clock-like device made of bronze gears, which looks much more advanced than its contemporary technological achievements. It is based on mathematics attributed to the Hipparchus and possibly carries knowledge and tradition that goes back to Archimedes, who according to ancient texts constructed several automata, including astronomical devices, a mechanical planetarium and a celestial sphere. The Antikythera Mechanism probably had a beautiful and expensive box; looking possibly like a very elaborate miniature Greek Temple, perhaps decorated with golden ornaments, of an elegant Hellenistic style, even perhaps with automatic statuettes, `daemons', functioning as pointers that performed some of its operations. Made out of appropriately tailored trains of gears that enable to perform specialised calculations, the mechanism carries concentric scales and pointers, in one side showing the position of the Sun in the ecliptic and the sky, possibly giving the time, hour of the day or night, like a clock. The position of the Moon and its phase is also shown during the month. On the other side of the Mechanism, having probably the size of a box (main part 32×20×6 cm), are two large spiral scales with two pointers showing the time in two different very long calendars, the first one concerning the eclipses, and lasting 18 years 11 days and 8 hours, the Saros period, repeating the solar and lunar eclipses, and enabling their prediction, and the 19 year cycle of Meton, that is the period the Moon reappears in the same place of the sky, with the same phase. An additional four-year dial shows the year of all Greek Festivities, the so-called `games' (Olympic, Pythian, Isthmian etc). Two additional dials give the Exeligmos, the 54 year and 34 day cycle, which provides a more accurate prediction of eclipses. It is possible that the Mechanism was also equipped with a planetary show display, as three of the planets and their motion (stationary points) are mentioned many times in the manual of the instrument, so it was also a planetarium. From the manual we have hints that the mechanism was probably also an observational instrument, as having instructions concerning a viewfinder and possibly how to orient the viewfinder to pass a sunbeam through it, probably measuring the altitude of the Sun. There are fragmented sentences that probably give instructions on how to move the pointers to set the position of the Sun, the Moon and the planets in their initial places in the ecliptic, on a specific day, or how to measure angular distances between two celestial bodies or their coordinates. This mechanism is definitely not the first one of its kind. The fact that it is accompanied with instructions means that the constructor had in its mind to be used by somebody else and one posits that he made at least another similar instrument.

  18. Recent Developments in Topical Wound Therapy: Impact of Antimicrobiological Changes and Rebalancing the Wound Milieu

    PubMed Central

    Erfurt-Berge, Cornelia; Renner, Regina

    2014-01-01

    Wound therapy improves every year by developing new wound treatment options or by advancing already existing wound materials, for example, adding self-releasing analgesic drugs or growth factors to wound dressings, or by binding and inactivating excessive proteases. Also new dressing materials based on silk fibers and enhanced methods to reduce bacterial burden, for example, cold argon plasma, might help to fasten wound healing. PMID:24829919

  19. The Differential Hormonal Milieu of Morning versus Evening May Have an Impact on Muscle Hypertrophic Potential.

    PubMed

    Burley, Simon D; Whittingham-Dowd, Jayde; Allen, Jeremy; Grosset, Jean-Francois; Onambele-Pearson, Gladys L

    2016-01-01

    Substantial gains in muscle strength and hypertrophy are clearly associated with the routine performance of resistance training. What is less evident is the optimal timing of the resistance training stimulus to elicit these significant functional and structural skeletal muscle changes. Therefore, this investigation determined the impact of a single bout of resistance training performed either in the morning or evening upon acute anabolic signalling (insulin-like growth factor-binding protein-3 (IGFBP-3), myogenic index and differentiation) and catabolic processes (cortisol). Twenty-four male participants (age 21.4±1.9yrs, mass 83.7±13.7kg) with no sustained resistance training experience were allocated to a resistance exercise group (REP). Sixteen of the 24 participants were randomly selected to perform an additional non-exercising control group (CP) protocol. REP performed two bouts of resistance exercise (80% 1RM) in the morning (AM: 0800 hrs) and evening (PM: 1800 hrs), with the sessions separated by a minimum of 72 hours. Venous blood was collected immediately prior to, and 5 min after, each resistance exercise and control sessions. Serum cortisol and IGFBP-3 levels, myogenic index, myotube width, were determined at each sampling period. All data are reported as mean ± SEM, statistical significance was set at P≤0.05. As expected a significant reduction in evening cortisol concentration was observed at pre (AM: 98.4±10.5, PM: 49.8±4.4 ng/ml, P<0.001) and post (AM: 98.0±9.0, PM: 52.7±6.0 ng/ml, P<0.001) exercise. Interestingly, individual cortisol differences pre vs post exercise indicate a time-of-day effect (AM difference: -2±2.6%, PM difference: 14.0±6.7%, P = 0.03). A time-of-day related elevation in serum IGFBP-3 (AM: 3274.9 ± 345.2, PM: 3605.1 ± 367.5, p = 0.032) was also evident. Pre exercise myogenic index (AM: 8.0±0.6%, PM: 16.8±1.1%) and myotube width (AM: 48.0±3.0, PM: 71.6±1.9 μm) were significantly elevated (P<0.001) in the evening. Post exercise myogenic index was greater AM (11.5±1.6%) compared with PM (4.6±0.9%). No difference was observed in myotube width (AM: 48.5±1.5, PM: 47.8±1.8 μm) (P>0.05). Timing of resistance training regimen in the evening appears to augment some markers of hypertrophic potential, with elevated IGFBP-3, suppressed cortisol and a superior cellular environment. Further investigation, to further elucidate the time course of peak anabolic signalling in morning vs evening training conditions, are timely. PMID:27583459

  20. [Sultopride, treatment of choice for psychomotor agitation in severe encephalopathy. 33 cases in a neuropediatric milieu].

    PubMed

    Gadisseux, J F; Fournaux, J; Hallet, J; Ferriere, G

    1982-01-01

    Thirty-three patients showing a definite group of symptoms including chiefly agitation or self-mutilation often dramatic have been treated with sultopride at doses ranging from 7 to 50 mg/kg/day at the Institut Médico-Pédagogique de l'Enfant-Jésus at Ciney. Forty-eight per cent showing this particular symptoms have been cured or greatly improved with sultopride. In 36% the response was incomplete in that it appeared to be identical with sultopride solely or with the previous medications. An opposite result has been noted in 16% only. Side-effects consisted in extra-pyramidal symptoms, drowsiness and digestive disorders. This study leads to the conclusion that sultopride can be considered as the most efficient therapeutical approach to the management of agitation or self-mutilation in severe encephalopathy.

  1. Adolescent and young adult patients with cancer: a milieu of unique features.

    PubMed

    Sender, Leonard; Zabokrtsky, Keri B

    2015-08-01

    Adolescent and young adult (AYA) patients with cancer are a unique category of patients who, depending on age at time of diagnosis, might receive treatment from oncologists specializing either in the treatment of children or adults. In the USA, AYA oncology generally encompasses patients 15-39 years of age. AYA patients with cancer typically present with diseases that span the spectrum from 'paediatric' cancers (such as acute lymphoblastic leukaemia [ALL] and brain tumours) to 'adult' tumours (such as breast cancer and melanoma), as well as cancers that are largely unique to their age group (such as testicular cancer and bone tumours). Research indicates that outcomes of AYA patients with cancer are influenced not only by the treatment provided, but also by factors related to 'host' biology. In addition to the potential biological and cancer-specific differences between AYAs and other patients with cancer, AYA patients also often have disparate access to clinical trials and suffer from a lack of age-appropriate psychosocial support services and health services, which might influence survival as well as overall quality of life. In this Review, these issues are discussed, with a focus on two types of AYA cancer--ALL and melanoma--highlighting findings arising from the use of emerging technologies, such as whole-genome sequencing. PMID:26011488

  2. Teledetection passive et processus decisionnel a reference spatiale: Application a l'aquaculture en milieu marin

    NASA Astrophysics Data System (ADS)

    Habbane, Mohamed

    L'objectif de cette etude est d'elaborer un processus decisionnel a reference spatiale (PDRS) pour la mariculture. Le PDRS est applique aux eaux cotieres de la baie des Chaleurs, dans le golfe du Saint-Laurent (Canada). Une carte preliminaire regionale d'indices du potentiel maricole, d'une limite de resolution spatiale de 1 kmsp2, est produite avec des parametres du niveau 1. Ces parametres englobent la temperature de l'eau de surface, extraite des images AVHRR, la salinite, les courants ainsi que les pigments chlorophylliens, quantifies a l'aide de mesures in situ. Les images AVHRR, prises en 1994, ont ete utiliees comme reference primaire pour selectionner des aires pouvant supporter une activite maricole sur la cote nord de la baie des Chaleurs. La temperature de surface extraite de ces images permet une analyse mesoechelle a la fois qualitative et quantitative des processus cotiers observes pendant la periode d'acquisition des donnees. Les autres donnees, soit la salinite, les courants et les concentrations en pigments chlorophylliens, sont analysees de facon a identifier la variabilite spatio-temporelle des caracteristiques des eaux de surface. L'ensemble des informations permet de produire une carte preliminaire regionale d'indices du potentiel maricole de la partie centrale de la baie des Chaleurs. Selon cet indice (defini entre 0 et 1), le secteur de potentiel aquicole de 0,5 a 0,75 s'etend sur une superficie d'environ 300 kmsp2. La localisation de cette aire potentielle est en accord avec les fortes concentrations en pigments chlrophylliens, presentant des conditions environnementales ideales a une haute productivite biologique. Par la suite la carte preliminaire est modifiee en tenant compte des parametres du niveau 2. Ces parametres sont la geomorphologie littorale, la bathymetrie, les sediments en suspension, les vents, les vagues, le debit d'eau douce, la glace marine, le carbone organique dissous, les aires de peche et les sources de pollution. Ces parametres sont compares deux a deux par rapport a la carte preliminaire regionale d'indices du potentiel maricole pour determiner leur poids relatif. La carte finale produite avec ces parametres du niveau 2 presente un secteur ou les indices du potentiel maricole sont de 0,5 a 0,75. Ce secteur longe la cote et epouse les isobathes de 10 a 30 m de profondeur. L'effet de la profondeur d'eau semble avoir jouer un role important. Le secteur de potentiel maricole de 0,25 a 0,5 est toujours present et couvre une superficie d'environ 426 kmsp2. L'etude necessitera toujours un suivi des conditions environnementales prevalant dans la region. Ce suivi peut etre effectue a l'aide d'un outil de vision aerospatiale (capteurs de teledetection) et d'analyse spatio-temporelle (SIG-PDRS). (Abstract shortened by UMI.)

  3. TPL2 kinase regulates the inflammatory milieu of the myeloma niche

    PubMed Central

    Hope, Chelsea; Ollar, Samuel J.; Heninger, Erika; Hebron, Ellen; Jensen, Jeffrey L.; Kim, Jaehyup; Maroulakou, Ioanna; Miyamoto, Shigeki; Leith, Catherine; Yang, David T.; Callander, Natalie; Hematti, Peiman; Chesi, Marta; Bergsagel, P. Leif

    2014-01-01

    Targeted modulation of microenvironmental regulatory pathways may be essential to control myeloma and other genetically/clonally heterogeneous cancers. Here we report that human myeloma–associated monocytes/macrophages (MAM), but not myeloma plasma cells, constitute the predominant source of interleukin-1β (IL-1β), IL-10, and tumor necrosis factor-α at diagnosis, whereas IL-6 originates from stromal cells and macrophages. To dissect MAM activation/cytokine pathways, we analyzed Toll-like receptor (TLR) expression in human myeloma CD14+ cells. We observed coregulation of TLR2 and TLR6 expression correlating with local processing of versican, a proteoglycan TLR2/6 agonist linked to carcinoma progression. Versican has not been mechanistically implicated in myeloma pathogenesis. We hypothesized that the most readily accessible target in the versican-TLR2/6 pathway would be the mitogen-activated protein 3 (MAP3) kinase, TPL2 (Cot/MAP3K8). Ablation of Tpl2 in the genetically engineered in vivo myeloma model, Vκ*MYC, led to prolonged disease latency associated with plasma cell growth defect. Tpl2 loss abrogated the “inflammatory switch” in MAM within nascent myeloma lesions and licensed macrophage repolarization in established tumors. MYC activation/expression in plasma cells was independent of Tpl2 activity. Pharmacologic TPL2 inhibition in human monocytes led to dose-dependent attenuation of IL-1β induction/secretion in response to TLR2 stimulation. Our results highlight a TLR2/6-dependent TPL2 pathway as novel therapeutic target acting nonautonomously through macrophages to control myeloma progression. PMID:24723682

  4. "Mesogeny" (Milieu-Mediated Maturation) Versus Endogeny: A Crucial Underemphasis in Piaget's "Internally-Caused" Phases.

    ERIC Educational Resources Information Center

    Burger, Henry G.

    The author credits Piaget for giving an operational definition of deduction and for his descriptions of child behavior. But he states that the latter apply only to white, middle-class urban youths in Switzerland in the first half of the 20th century and cannot support Piaget's claims about invariant stages of intellectual development for all…

  5. Proceedings of a Symposium on the Educational Process and Social Change in a Specialized Environmental Milieu.

    ERIC Educational Resources Information Center

    Alberta Univ., Edmonton. Boreal Inst.

    Four papers examine theoretical and practical aspects of educational problems found in the northern regions of the world, the two major problems being that vast distances separate the small communities and that there are great differences between living patterns of native inhabitants and those patterns demanded by modern society. "The Role and…

  6. Urban effluent discharges as causes of public and environmental health concerns in South Africa's aquatic milieu.

    PubMed

    Sibanda, Timothy; Selvarajan, Ramganesh; Tekere, Memory

    2015-12-01

    The water quality in South Africa's river systems is rapidly deteriorating as a consequence of increased discharge of wastewater effluents. The natural ability of rivers and reservoirs to trap toxic chemicals and nutrients in their sediments enables these systems to accumulate contaminants, altering the natural balance in environmental water quality, thereby raising a plethora of public and environmental health concerns. Impaired water quality has been linked to an array of problems in South Africa including massive fish mortalities, altered habitat template leading to the thinning of riverine macroinvertebrate diversity, shifts in microbial community structures with drastic ecological consequences and evolvement of antibiotic resistance genes that, under natural conditions, can be transferred to waterborne pathogens. Urban wastewater discharge has also been implicated in increased bioaccumulation of metals in edible plant parts, elevated concentrations of endocrine-disrupting compounds (EDCs), which are blamed for reduced fertility and increased cancer risk, excessive growth of toxic cyanobacteria and an increase in concentrations of pathogenic microorganisms which constitute a potential health threat to humans. However, despite the ecotoxicological hazards posed by wastewater effluents, ecotoxicological studies are currently underutilised in South African aquatic ecosystem assessments, and where they have been done, the observation is that ecotoxicological studies are mostly experimental and restricted to small study areas. More research is still needed to fully assess especially the ecotoxicological consequences of surface water pollution by urban wastewater effluents in South Africa. A review of the effects of urban effluent discharges that include domestic effluent mixed with industrial effluent and/or urban stormwater run-off is hereby presented. PMID:26408112

  7. Expression profiling of lymph nodes in tuberculosis patients reveal inflammatory milieu at site of infection

    PubMed Central

    Maji, Abhijit; Misra, Richa; Kumar Mondal, Anupam; Kumar, Dhirendra; Bajaj, Divya; Singhal, Anshika; Arora, Gunjan; Bhaduri, Asani; Sajid, Andaleeb; Bhatia, Sugandha; Singh, Sompal; Singh, Harshvardhan; Rao, Vivek; Dash, Debasis; Baby Shalini, E; Sarojini Michael, Joy; Chaudhary, Anil; Gokhale, Rajesh S.; Singh, Yogendra

    2015-01-01

    Extrapulmonary manifestations constitute 15 to 20% of tuberculosis cases, with lymph node tuberculosis (LNTB) as the most common form of infection. However, diagnosis and treatment advances are hindered by lack of understanding of LNTB biology. To identify host response, Mycobacterium tuberculosis infected lymph nodes from LNTB patients were studied by means of transcriptomics and quantitative proteomics analyses. The selected targets obtained by comparative analyses were validated by quantitative PCR and immunohistochemistry. This approach provided expression data for 8,728 transcripts and 102 proteins, differentially regulated in the infected human lymph node. Enhanced inflammation with upregulation of T-helper1-related genes, combined with marked dysregulation of matrix metalloproteinases, indicates tissue damage due to high immunoactivity at infected niche. This expression signature was accompanied by significant upregulation of an immunoregulatory gene, leukotriene A4 hydrolase, at both transcript and protein levels. Comparative transcriptional analyses revealed LNTB-specific perturbations. In contrast to pulmonary TB-associated increase in lipid metabolism, genes involved in fatty-acid metabolism were found to be downregulated in LNTB suggesting differential lipid metabolic signature. This study investigates the tissue molecular signature of LNTB patients for the first time and presents findings that indicate the possible mechanism of disease pathology through dysregulation of inflammatory and tissue-repair processes. PMID:26469538

  8. [Vitalism and mechanism: their meanings in the milieu of the 17th and 18th centuries].

    PubMed

    Hwang, S I

    1993-01-01

    The views on the life in the early modern period (the 17th and 18th centuries) with their socio-cultural backgrounds and their meanings at that time were discussed in this paper. Those views discussed here were the dualistic, mechanistic one of Rene Descartes (1596-1650), the animistic, vitalistic one of Georg Ernst Stahl (1660-1734), and the monistic, mechanistic one of Julien Offray de la Mettrie (1709-1751). Author stressed that the processes of their view formation were influenced by the wide range of the various political and religious factors as well as the scientific, medical facts and opinions at that time, and that not only the contents of the views but also their historical contexts should be pursued in the study on the medical thoughts.

  9. Children with Anxiety Disorders: Use of a Cognitive Behavioral Therapy Model within a Social Milieu

    ERIC Educational Resources Information Center

    Kearny, Regina; Pawlukewicz, Justine; Guardino, Mary

    2014-01-01

    Because anxiety is the most common mental health disorder diagnosed in children, early intervention is crucial for fundamental coping. Although cognitive-behavioral therapy (CBT) is the preferred treatment method for this affective disorder, instruction for children needs to be specific for them to successfully acquire and implement essential CBT…

  10. Recent developments in topical wound therapy: impact of antimicrobiological changes and rebalancing the wound milieu.

    PubMed

    Erfurt-Berge, Cornelia; Renner, Regina

    2014-01-01

    Wound therapy improves every year by developing new wound treatment options or by advancing already existing wound materials, for example, adding self-releasing analgesic drugs or growth factors to wound dressings, or by binding and inactivating excessive proteases. Also new dressing materials based on silk fibers and enhanced methods to reduce bacterial burden, for example, cold argon plasma, might help to fasten wound healing.

  11. Targeting the Peroxisome Proliferator-Activated Receptor-γ to Counter the Inflammatory Milieu in Obesity.

    PubMed

    Corzo, Cesar; Griffin, Patrick R

    2013-12-01

    Adipose tissue, which was once viewed as a simple organ for storage of triglycerides, is now considered an important endocrine organ. Abnormal adipose tissue mass is associated with defects in endocrine and metabolic functions which are the underlying causes of the metabolic syndrome. Many adipokines, hormones secreted by adipose tissue, regulate cells from the immune system. Interestingly, most of these adipokines are proinflammatory mediators, which increase dramatically in the obese state and are believed to be involved in the pathogenesis of insulin resistance. Drugs that target peroxisome proliferator-activated receptor-γ have been shown to possess anti-inflammatory effects in animal models of diabetes. These findings, and the link between inflammation and the metabolic syndrome, will be reviewed here.

  12. Targeting the Peroxisome Proliferator-Activated Receptor-γ to Counter the Inflammatory Milieu in Obesity

    PubMed Central

    Corzo, Cesar

    2013-01-01

    Adipose tissue, which was once viewed as a simple organ for storage of triglycerides, is now considered an important endocrine organ. Abnormal adipose tissue mass is associated with defects in endocrine and metabolic functions which are the underlying causes of the metabolic syndrome. Many adipokines, hormones secreted by adipose tissue, regulate cells from the immune system. Interestingly, most of these adipokines are proinflammatory mediators, which increase dramatically in the obese state and are believed to be involved in the pathogenesis of insulin resistance. Drugs that target peroxisome proliferator-activated receptor-γ have been shown to possess anti-inflammatory effects in animal models of diabetes. These findings, and the link between inflammation and the metabolic syndrome, will be reviewed here. PMID:24404510

  13. Modulating the Immune Response Towards a Neuroregenerative Peri-injury Milieu After Cerebral Hemorrhage.

    PubMed

    Klebe, Damon; McBride, Devin; Flores, Jerry J; Zhang, John H; Tang, Jiping

    2015-12-01

    Cerebral hemorrhages account for 15-20 % of stroke sub-types and have very poor prognoses. The mortality rate for cerebral hemorrhage patients is between 40 and 50 %, of which at least half of the deaths occur within the first 2 days, and 75 % of survivors are incapable of living independently after 1 year. Current emergency interventions involve lowering blood pressure and reducing intracranial pressure by controlled ventilations or, in the worst case scenarios, surgical intervention. Some hemostatic and coagulatherapeutic interventions are being investigated, although a few that were promising in experimental studies have failed in clinical trials. No significant immunomodulatory intervention, however, exists for clinical management of cerebral hemorrhage. The inflammatory response following cerebral hemorrhage is particularly harmful in the acute stage because blood-brain barrier disruption is amplified and surrounding tissue is destroyed by secreted proteases and reactive oxygen species from infiltrated leukocytes. In this review, we discuss both the destructive and regenerative roles the immune response play following cerebral hemorrhage and focus on microglia, macrophages, and T-lymphocytes as the primary agents directing the response. Microglia, macrophages, and T-lymphocytes each have sub-types that significantly influence the over-arching immune response towards either a pro-inflammatory, destructive, or an anti-inflammatory, regenerative, state. Both pre-clinical and clinical studies of cerebral hemorrhages that selectively target these immune cells are reviewed and we suggest immunomodulatory therapies that reduce inflammation, while augmenting neural repair, will improve overall cerebral hemorrhage outcomes. PMID:25946986

  14. The Differential Hormonal Milieu of Morning versus Evening May Have an Impact on Muscle Hypertrophic Potential

    PubMed Central

    Allen, Jeremy; Grosset, Jean-Francois

    2016-01-01

    Substantial gains in muscle strength and hypertrophy are clearly associated with the routine performance of resistance training. What is less evident is the optimal timing of the resistance training stimulus to elicit these significant functional and structural skeletal muscle changes. Therefore, this investigation determined the impact of a single bout of resistance training performed either in the morning or evening upon acute anabolic signalling (insulin-like growth factor-binding protein-3 (IGFBP-3), myogenic index and differentiation) and catabolic processes (cortisol). Twenty-four male participants (age 21.4±1.9yrs, mass 83.7±13.7kg) with no sustained resistance training experience were allocated to a resistance exercise group (REP). Sixteen of the 24 participants were randomly selected to perform an additional non-exercising control group (CP) protocol. REP performed two bouts of resistance exercise (80% 1RM) in the morning (AM: 0800 hrs) and evening (PM: 1800 hrs), with the sessions separated by a minimum of 72 hours. Venous blood was collected immediately prior to, and 5 min after, each resistance exercise and control sessions. Serum cortisol and IGFBP-3 levels, myogenic index, myotube width, were determined at each sampling period. All data are reported as mean ± SEM, statistical significance was set at P≤0.05. As expected a significant reduction in evening cortisol concentration was observed at pre (AM: 98.4±10.5, PM: 49.8±4.4 ng/ml, P<0.001) and post (AM: 98.0±9.0, PM: 52.7±6.0 ng/ml, P<0.001) exercise. Interestingly, individual cortisol differences pre vs post exercise indicate a time-of-day effect (AM difference: -2±2.6%, PM difference: 14.0±6.7%, P = 0.03). A time-of-day related elevation in serum IGFBP-3 (AM: 3274.9 ± 345.2, PM: 3605.1 ± 367.5, p = 0.032) was also evident. Pre exercise myogenic index (AM: 8.0±0.6%, PM: 16.8±1.1%) and myotube width (AM: 48.0±3.0, PM: 71.6±1.9 μm) were significantly elevated (P<0.001) in the evening. Post exercise myogenic index was greater AM (11.5±1.6%) compared with PM (4.6±0.9%). No difference was observed in myotube width (AM: 48.5±1.5, PM: 47.8±1.8 μm) (P>0.05). Timing of resistance training regimen in the evening appears to augment some markers of hypertrophic potential, with elevated IGFBP-3, suppressed cortisol and a superior cellular environment. Further investigation, to further elucidate the time course of peak anabolic signalling in morning vs evening training conditions, are timely. PMID:27583459

  15. Reality Orientation: A Milieu Therapy Used in an Institution for the Aged.

    ERIC Educational Resources Information Center

    Citrin, Richard S.; Dixon, David N.

    This study reports an experimentally designed evaluation of Reality Orientation. Twelve elderly residents were chosen for the experimental group and 13 residents were chosen for the no-treatment control group. Both classroom Reality Orientation and 24-hour Reality Orientation were introduced on the experimental floor. A pretest-posttest control…

  16. Changes in Personality Disorder Traits Following 2 Years of Treatment in a Secure Therapeutic Community Milieu

    ERIC Educational Resources Information Center

    Morrissey, Catrin; Taylor, Jon

    2014-01-01

    Therapeutic community treatment models have not previously been applied to forensic patients with mild intellectual disabilities (IDs) with a comorbid diagnosis of personality disorder. Thirteen patients with mild IDs were allocated to a unit within a high secure psychiatric service operating a model of treatment based on the principles and…

  17. Homeostasis, the Milieu Intérieur, and the Wisdom of the Nephron

    PubMed Central

    Zeidel, Mark L.

    2014-01-01

    The concept of homeostasis has been inextricably linked to the function of the kidneys for more than a century when it was recognized that the kidneys had the ability to maintain the “internal milieu” and allow organisms the “physiologic freedom” to move into varying environments and take in varying diets and fluids. Early ingenious, albeit rudimentary, experiments unlocked a wealth of secrets on the mechanisms involved in the formation of urine and renal handling of the gamut of electrolytes, as well as that of water, acid, and protein. Recent scientific advances have confirmed these prescient postulates such that the modern clinician is the beneficiary of a rich understanding of the nephron and the kidney’s critical role in homeostasis down to the molecular level. This review summarizes those early achievements and provides a framework and introduction for the new CJASN series on renal physiology. PMID:24789550

  18. The Relationship between Teacher Language Use in Enhanced Milieu Teaching Sessions and Child Language Outcomes

    ERIC Educational Resources Information Center

    McLeod, Jennifer Ragan Henderson

    2010-01-01

    Research indicates that linguistic input from teachers may affect child vocabulary development in preschool and beyond (Dickinson & Tabors, 2001). Currently, there is little research on the relationship between specific teacher language use in individual interactions on child language outcomes for preschool children at risk for academic delays.…

  19. Foregut exclusion disrupts intestinal glucose sensing and alters portal nutrient and hormonal milieu.

    PubMed

    Pal, Atanu; Rhoads, David B; Tavakkoli, Ali

    2015-06-01

    The antidiabetes effects of Roux-en-Y gastric bypass (RYGB) are well-known, but the underlying mechanisms remain unclear. Isolating the proximal small intestine, and in particular its luminal glucose sensors, from the nutrient stream has been proposed as a critical change, but the pathways involved are unclear. In a rodent model, we tested the effects of isolating and then stimulating a segment of proximal intestine using glucose analogs to examine their impact on glucose absorption (Gabsorp) and hormone secretion after a glucose bolus into the distal jejunum. Analogs selective for sodium-glucose cotransporter (SGLT) family members and the sweet taste receptor were tested, and measurements of the portosystemic gradient were used to determine Gabsorp and hormone secretion, including GLP-1. Proximal intestinal isolation reduced Gabsorp and GLP-1 secretion. Stimulation of the glucose-sensing protein SGLT3 increased Gabsorp and GLP-1 secretion. These effects were abolished by vagotomy. Sweet taste receptor stimulation only increased GLP-1 secretion. This study suggests a novel role for SGLT3 in coordinating intestinal function, as reflected by the concomitant modulation of Gabsorp and GLP-1 secretion, with these effects being mediated by the vagus nerve. Our findings provide potential mechanistic insights into foregut exclusion in RYGB and identify SGLT3 as a possible antidiabetes therapeutic target.

  20. From Knowledge to Wisdom: A New Challenge to the Educational Milieu with Implications for Religious Education

    ERIC Educational Resources Information Center

    Martin, Miriam K.; de Pison, Ramon Martinez

    2005-01-01

    The epistemological paradigm, known as post-modernity, challenges some of the presuppositions of educational systems in general, and of religious education in particular. One of these presuppositions is the exaggerated primacy given to knowledge attained through reason. However, the paradigm shift invites us to make a transition from knowledge to…

  1. Stress among Secondary School Teachers in Ebonyi State, Nigeria: Suggested Interventions in the Worksite Milieu

    ERIC Educational Resources Information Center

    Nwimo, Ignatius O.; Onwunaka, Chinagorom

    2015-01-01

    The aim of the study was to determine the level of stress experienced by secondary school teachers in Ebonyi State. The dimensions of stress studied included physical stress, mental stress, emotional stress and social stress. The study adopted the cross-sectional survey design using a sample of 660 (male 259, female 401) teachers randomly drawn…

  2. Nanoparticle-based highly sensitive MRI contrast agents with enhanced relaxivity in reductive milieu.

    PubMed

    Sigg, Severin J; Santini, Francesco; Najer, Adrian; Richard, Pascal U; Meier, Wolfgang P; Palivan, Cornelia G

    2016-08-01

    Current magnetic resonance imaging (MRI) contrast agents often produce insufficient contrast for diagnosis of early disease stages, and do not sense their biochemical environments. Herein, we report a highly sensitive nanoparticle-based MRI probe with r1 relaxivity up to 51.7 ± 1.2 mM(-1) s(-1) (3T). Nanoparticles were co-assembled from Gd(3+) complexed to heparin-poly(dimethylsiloxane) copolymer, and a reduction-sensitive amphiphilic peptide serving to induce responsiveness to environmental changes. The release of the peptide components leads to a r1 relaxivity increase under reducing conditions and increases the MRI contrast. In addition, this MRI probe has several advantages, such as a low cellular uptake, no apparent cellular toxicity (tested up to 1 mM Gd(3+)), absence of an anticoagulation property, and a high shelf stability (no increase in free Gd(3+) over 7 months). Thus, this highly sensitive T1 MRI contrast nanoparticle system represents a promising probe for early diagnosis through possible accumulation and contrast enhancement within reductive extracellular tumour tissue. PMID:27435820

  3. Urban effluent discharges as causes of public and environmental health concerns in South Africa's aquatic milieu.

    PubMed

    Sibanda, Timothy; Selvarajan, Ramganesh; Tekere, Memory

    2015-12-01

    The water quality in South Africa's river systems is rapidly deteriorating as a consequence of increased discharge of wastewater effluents. The natural ability of rivers and reservoirs to trap toxic chemicals and nutrients in their sediments enables these systems to accumulate contaminants, altering the natural balance in environmental water quality, thereby raising a plethora of public and environmental health concerns. Impaired water quality has been linked to an array of problems in South Africa including massive fish mortalities, altered habitat template leading to the thinning of riverine macroinvertebrate diversity, shifts in microbial community structures with drastic ecological consequences and evolvement of antibiotic resistance genes that, under natural conditions, can be transferred to waterborne pathogens. Urban wastewater discharge has also been implicated in increased bioaccumulation of metals in edible plant parts, elevated concentrations of endocrine-disrupting compounds (EDCs), which are blamed for reduced fertility and increased cancer risk, excessive growth of toxic cyanobacteria and an increase in concentrations of pathogenic microorganisms which constitute a potential health threat to humans. However, despite the ecotoxicological hazards posed by wastewater effluents, ecotoxicological studies are currently underutilised in South African aquatic ecosystem assessments, and where they have been done, the observation is that ecotoxicological studies are mostly experimental and restricted to small study areas. More research is still needed to fully assess especially the ecotoxicological consequences of surface water pollution by urban wastewater effluents in South Africa. A review of the effects of urban effluent discharges that include domestic effluent mixed with industrial effluent and/or urban stormwater run-off is hereby presented.

  4. [Epidemiologic surveillance of dengue fever: non specific alert system in the hospital milieu in Cayenne].

    PubMed

    Carme, B; Sobesky, M; Joubert, M; Egmann, G; Cotellon, P

    2000-02-01

    A retrospective study was carried out in the General Hospital of Cayenne, the main city in French Guiana, where malaria is endemic and dengue fever constitutes a permanent threat. The aim of this study was to test an alert system for epidemic outbreaks of dengue fever. Patients attending the emergency ward and for whom a search of Plasmodium was prescribed were included. In 90% of cases, patients were febrile, presenting clinical symptoms compatible with malaria or dengue fever-like syndrome. The period of survey covered 39 months (January 1996 to March 1999). Three indices were studied; two non specific: EMN (Emergency Malaria Negative--UPN in French): number of negative malaria blood tests for patients having consulted the emergency ward; EMNT (Emergency Malaria Negative Thrombopenia--UPNT in French): UPN with platelets < 150.000; and one more specific; number of hospitalised dengue fever cases according to data from a hospital programme on medical systems information. EMN weekly follow-ups led to three epidemic alerts, two of which turned out to be crucial for dengue. Accounting for thrombopenia (EMNT) reinforced the specificity. This simple and reactive alert system should incite increased serological and virological surveillance and contribute to precocious antivectorial control measures in districts where several dengue fever cases are suspected.

  5. Lexique et classes sociales en milieu scolaire (Vocabulary and Social Classes in School Surroundings)

    ERIC Educational Resources Information Center

    Buzon, Christian

    1977-01-01

    An analysis of differences in lexical usage among children of different socio-cultural milieux. This study uses other sociological and linguistic studies. It includes twenty-three tables, and presents in conclusion the results obtained, differentiation of the groups and the problems posed by isolation of only one variable. (Text is in French.)…

  6. Resistant Readers 8 Months Later: Energizing the Student's Learning Milieu by Targeted Counselling

    ERIC Educational Resources Information Center

    Andreassen, Anne Brit; Knivsberg, Ann Mari; Niemi, Pekka

    2006-01-01

    Several studies have reported that an alarming large subgroup of poor readers seems to be treatment resistant. This group obviously needs attention beyond standard special education instructions. In Norway, the National Centre for Reading Education and Research has been assigned the task of assisting the school psychological services nationwide in…

  7. Resistant readers 8 months later: energizing the student's learning milieu by targeted counselling.

    PubMed

    Andreassen, Anne Brit; Knivsberg, Ann Mari; Niemi, Pekka

    2006-05-01

    Several studies have reported that an alarming large subgroup of poor readers seems to be treatment resistant. This group obviously needs attention beyond standard special education instructions. In Norway, the National Centre for Reading Education and Research has been assigned the task of assisting the school psychological services nationwide in severe cases of reading disabilities. The aim of the present study of a clinical sample of students with severe dyslexia, due to phonological deficits, was to evaluate effects of counselling 8 months after a 2-day assessment at the centre. Sixty-five students, with a mean age of 12.3 years, participated. A thorough assessment of each student's strengths and problems was conducted at the centre. Additional information was obtained from the school psychological services, the teachers, and the parents. Diagnostic reports and proposals for remediation were forwarded to the school psychological services. Students', parents', and teachers' evaluation of the students' reading abilities 8 months after the assessment was retrieved for 75% of cases. Of these, 80% reported clear progress in the students' reading abilities. The progress could not be related to age, cognitive level, place of residence, or previous special education received, but instead to improved motivation.

  8. [Clinical aspects, epidemiology and economic impact of foot epidermomycosis in an industrial milieu].

    PubMed

    Grosshans, E; Schwaab, E; Samsoen, M; Grange, D; Koenig, H; Kremer, M

    1986-01-01

    Fungal infections of the feet are very common in some professions. This has been particularly studied in coal mine workers up to 50 p. 100 of whom were found to have dermatophytosis of the feet. The purpose of this study was to determine the clinical, epidemiological and evolutive characteristics of interdigital and plantar intertrigo of the feet among people working in a coking plant, a potash mine and a motorcar factory. We have also evaluated the cost of treatments in relation to their immediate effectiveness and their preventive effects on relapses. Initially, 208 workers entered the study: 84 (40.7 p. 100) had a mycotic infection (M) and 124 (59.3 p. 100) presented with a non-mycotic (NM) inflammation between the toes and on the soles, characterized by maceration of the skin, hyperhidrosis and bromhidrosis. Change in the lesions under treatment were subjected to statistical analysis. In both M and NM groups the workers were allocated by randomization to a double-blind treatment consisting of: group M: either 2 p. 100 miconazole powder or talcum powder with 2 p. 100 salicylic acid and boric acid; group NM: either 2 p. 100 miconazole powder or ordinary talcum powder. Each subject was seen on at least two occasions after 3 and 12 months of daily foot care and topical treatment. Mycological examinations in group M subjects showed that fungal infections of the feet were primarily due to Trichophyton mentagrophytes or to Trichophyton rubrum. A logistic regression analysis (BMDPLR program) of anamnestic and clinical data (table IV) led to a "mathematical model of the mycotic foot", characterized by 6 main parameters of statistically significant occurrence: a history of interdigital-plantar intertrigo, recurrent in 90 p. 100 of subjects in group M (significant association at 0.1 p. 100); a functional symptom, pruritus, present in 71 p. 100 of subjects with mycosis; the stronger, more disturbing the pruritus, the greater the probability of it being of fungal origin (significant association at 0.1 p. 100); 4 physical signs: lack of maceration (0.1 p. 100), lesions limited to the interdigital spaces and respecting the soles (0.1 p. 100), presence of interdigital fissures (0.5 p. 100) and vesiculation (2.5 p. 100). When the respective diagnostic values of these elementary symptoms were considered, it appeared that their various combinations might have predictive values which could be calculated.(ABSTRACT TRUNCATED AT 400 WORDS) PMID:2949683

  9. The effect of 17 beta-estradiol on cholesterol in human macrophages is influenced by the lipoprotein milieu

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Estrogen and testosterone are thought to modulate coronary heart disease (CHD) risk. To examine how these hormones affect human macrophage cholesterol transport, a key factor in atherogenesis, we obtained monocytes from healthy male and postmenopausal female donors (age 50-70 y). Cells were allowe...

  10. Work-Related Child-Care Centres in Canada, 2001 = Les garderies en milieu de travail au Canada, 2001.

    ERIC Educational Resources Information Center

    Barbeau, Carole

    Noting that the number of work-related child care centers has nearly doubled in the past 10 years in Canada, this report, in both English and French, details a study examining the current practices pertaining to work-related child care in Canada. The report highlights the best examples in this area and discusses what has been learned from the…

  11. The Social Milieu of the Church and Religious Coping Responses: A Longitudinal Investigation of Older Whites and Older Blacks

    PubMed Central

    Krause, Neal

    2010-01-01

    The purpose of this study is to see if the social environment of the church influences the use of religious coping responses over time. The following theoretical relationships were embedded in the conceptual model that was developed to evaluate this issue: (1) people who go to church more often are more likely to feel their congregation is highly cohesive (e.g., share the same values and beliefs); (2) individuals who worship in highly cohesive congregations are more likely to receive spiritual support (i.e., encouragement to adopt religious teachings and principles) from their fellow church members; (3) people who receive more spiritual support will be more likely to adopt religious coping responses. In the process of evaluating this model, tests were performed to examine the influence of racial culture. Data from a nationwide longitudinal survey of older adults provide support for each link in the conceptual model. Pervasive racial cultural differences were also found: Older blacks were more likely to be deeply involved in each facet of religion than older whites. PMID:20556239

  12. Benefices environnementaux de la cogeneration d'energie en milieu hospitalier et cas de l'Hopital de Moncton

    NASA Astrophysics Data System (ADS)

    Kone, Diakalia

    The present study aimed at assessing the environmental benefits of power management practices based on cogeneration in the particular industrial sector of hospitals and healthcare. Cogeneration power systems, also known as "Combined Heat and Power" (CHP) or Cogen, supply on-site electricity and heat from a single fuel source (natural gas in general). While the efficiency of conventional plants to produce power and heat separately is limited to about 30%, the efficiency of a CHP plant is close to 80% and can reach up to 90% in some applications (Borbely et Kreider, 2001). One of the distinctive features of hospitals is their continuous demand for both type of energy (electricity and heat), which makes them good candidate for cogeneration. However, in North America at the present time, less than 5% of hospitals run on CHP. Most are being supplied with electricity by conventional power plants, run by specialized companies, and use on-site boiler(s) to generate heat. Energy spending can reach up to 3% of an hospital's annual operational budget. There are also environmental impacts related to current energy supply and use in hospitals. For instance, the burning of fossil fuels releases greenhouse gases (GHG), which contribute to human health problems and climate change. The first objective of the study was to outline the main benefits and challenges faced by hospitals that aim at becoming their own energy co-generator, in comparison to having power and heat produced separately. Our second objective was to assess prospectively (proactively) the environmental impacts of a cogeneration plant that is being planned, but not yet operated, in a Canadian hospital. The methodology was based on literature reviews and on a case study, namely that of The Moncton Hospital (TMH)/L'Hopital de Moncton, Moncton, New Brunswick, Canada. This hospital is considered a large hospital with 375 beds and a major and expanding ambulatory care service. It is also in the process of developing a 1.06 MW cogeneration plant, to be run on natural gas, to meet about 30% of the facility's current demand for electricity and heat. In order to anticipate the environmental consequences of this CHP project, an environmental impact assessment (EIA) was conducted, according to the principles that apply in New Brunswick (Regulation 87-83 on EIA). A literature review was conducted and a matrix approach (matrix of impacts) was used to identify and assess the anticipated environmental impacts. The study showed that multiple stakeholders in the healthcare sector can reap benefits of CHP deployment. Facility owners can reduce energy costs and increase power reliability to enhance operations' continuity, during normal and extraordinary times (e.g., natural disasters). For instance, when hurricanes Katrina and Rita struck the United States in 2005, hospitals running with CHP were able to provide secure electricity supplies for emergency facilities and shelters. CHP also has environmental benefits related to its distinctively high efficiency. But its deployment in the healthcare sector also provides challenges, mainly due to the fact that power production is not a core activity for an hospital. These challenges can be overcome, however, as shown by numerous success stories in hospitals worldwide; specialised resources are available to help hospitals switch to CHP. This study underlines some of the steps a hospital can take toward this aim. EIA of The Moncton Hospital CHP project suggests that, globally, the environmental impacts of CHP are reduced compared to the traditional production of electricity and heat separately. Cogeneration utilizes fewer resources (fuel) and therefore releases fewer GHG and other pollutants. However, quantifying the emissions avoided is challenging. Also, the environmental benefits of CHP may be less obvious when compared to a centralised nuclear or hydraulic power production, which emits less GHG than power plants operating on coal or fuel oil. The study also indicates that other conditions are required to increase the environmental gains that can be expected from CHP deployment in the hospital sector. These conditions include the use of renewable fuel sources (biomass), the development of well-structured frameworks (e.g., efficient environmental management systems) to coordinate and leverage environmental stewardship initiatives within hospitals, and the development of energy partnerships (e.g., municipal heat networks). A broad, eco-systemic vision, like the one of industrial ecology, would help strengthen the ecological benefits of cogeneration in the hospital and health care sector. Key Words Heat and power cogeneration, hospitals, benefits/challenges, environment, society, environmental impact assessment, Canada, sustainable development, industrial ecology.

  13. Substance Use and Dependency Disorders in Adolescent Girls in Group Living Programs: Prevalence and Associations with Milieu Factors

    ERIC Educational Resources Information Center

    Baker, Amy J. L.; Ashare, Caryn; Charvat, Benjamin J.

    2009-01-01

    Fifty-three adolescent girls residing in community-based group-living child welfare programs were administered a standardized measure (SASS-2) in order to assess probability of a substance use/dependency disorder in this highly vulnerable population. Findings revealed that one third of the sample, and one half of the nonpregnant/parenting girls,…

  14. Shedding PEG Palisade by Temporal Photostimulation and Intracellular Reducing Milieu for Facilitated Intracellular Trafficking and DNA Release.

    PubMed

    Wang, Tieyan; Chen, Qixian; Lu, Hongguang; Li, Wei; Li, Zaifen; Ma, Jianbiao; Gao, Hui

    2016-08-17

    The dilemma of poly(ethylene glycol) surface modification (PEGylation) inspired us to develop an intracellularly sheddable PEG palisade for synthetic delivery systems. Here, we attempted to conjugate PEG to polyethylenimine (PEI) through tandem linkages of disulfide-bridge susceptible to cytoplasmic reduction and an azobenzene/cyclodextrin inclusion complex responsive to external photoirradiation. The subsequent investigations revealed that facile PEG detachment could be achieved in endosomes upon photoirradiation, consequently engendering exposure of membrane-disruptive PEI for facilitated endosome escape. The liberated formulation in the cytosol was further subjected to complete PEG detachment relying on disulfide cleavage in the reductive cytosol, thus accelerating dissociation of electrostatically assembled PEI/DNA polyplex to release DNA by means of polyion exchange reaction with intracellularly charged species, ultimately contributing to efficient gene expression.

  15. Some Considerations of the Effects of One's Social-Cultural Milieu on the Development of Spatial Conceptual Structures.

    ERIC Educational Resources Information Center

    Cohen, Herbert G.; Akarsu, Fusan

    1991-01-01

    Whether or not the spatial cognitive development of students from distinct social-cultural milieus, specifically Anglos from the southwestern part of the United States and Native Turks, would proceed along approximately the same lines was investigated. The overall findings tend to indicate that at times the acquisition of spatial structures may be…

  16. [Prevalence of dental caries in school milieu in the northwest of Côte d'Ivoire].

    PubMed

    Yao, K J; N'Da, N A; Koffi, N M

    2001-01-01

    The purpose of this study was to determine the prevalence of tooth decay and its correlation with dental care habits in northwestern Ivory Coast. Study was carried out in primary schools in the city of Odienne in January 1999. The study cohort comprised 500 students of both genders ranging in age from 4 to 15 years. The prevalence of tooth decay was 77.2% and the mean CAO index was 2.43. Dental care involved use of a chewing stick in 49% and a tooth brush in 50.8%. Only 5.6% of children cleaned their teeth three-times a day on a regular basis. Statistical analysis of study data demonstrated a correlation between the frequency of tooth cleaning and incidence of tooth decay. The incidence of tooth decay was 60.7% in students that cleaned their teeth three times a day versus 78.2% in students who cleaned their teeth less regularly. An educational campaign has been undertaken to inform students of the importance of oral hygiene in maintaining healthy teeth. A dental examination program would be useful to provide routine check-ups. A group study will be needed to monitor oral hygiene in students and evaluate the impact of these measures on tooth decay.

  17. The importance of selecting a proper biological milieu for protein corona analysis in vitro: Human plasma versus human serum.

    PubMed

    Mirshafiee, Vahid; Kim, Raehyun; Mahmoudi, Morteza; Kraft, Mary L

    2016-06-01

    Nanoparticle (NP) exposure to biological fluids in the body results in protein binding to the NP surface, which forms a protein coating that is called the "protein corona". To simplify studies of protein-NP interactions and protein corona formation, NPs are incubated with biological solutions, such as human serum or human plasma, and the effects of this exposure are characterized in vitro. Yet, how NP exposure to these two different biological milieus affects protein corona composition and cell response has not been investigated. Here, we explore the differences between the protein coronas that form when NPs are incubated in human serum versus human plasma. NP characterization indicated that NPs that were exposed to human plasma had higher amounts of proteins bound to their surfaces, and were slightly larger in size than those exposed to human serum. In addition, significant differences in corona composition were also detected with gel electrophoresis and liquid chromatography-mass spectrometry/mass spectrometry, where a higher fraction of coagulation proteins and complement factors were found on the plasma-exposed NPs. Flow cytometry and confocal microscopy showed that the uptake of plasma-exposed NPs was higher than that of serum-exposed NPs by RAW 264.7 macrophage immune cells, but not by NIH 3T3 fibroblast cells. This difference is likely due to the elevated amounts of opsonins, such as fibrinogen, on the surfaces of the NPs exposed to plasma, but not serum, because these components trigger NP internalization by immune cells. As the human plasma better mimics the composition of the in vivo environment, namely blood, in vitro protein corona studies should employ human plasma, and not human serum, so the biological phenomena that is observed is more similar to that occurring in vivo.

  18. Modelisation, conception et simulation des performances d'un collecteur solaire aeraulique a tubes sous vide en milieu nordique

    NASA Astrophysics Data System (ADS)

    Paradis, Pierre-Luc

    The global energy consumption is still increasing year after year even if different initiatives are set up to decrease fossil fuel dependency. In Canada 80% of the energy is used for space heating and domestic hot water heating in residential sector. This heat could be provided by solar thermal technologies despite few difficulties originating from the cold climate. The aim of this project is to design a solar evacuated tube thermal collector using air as the working fluid. Firstly, needs and specifications of the product are established in a clear way. Then, three concepts of collector are presented. The first one relies on the standard evacuated tube. The second one uses a new technology of tubes; both sides are open. The third one uses heat pipe to extract the heat from the tubes. Based on the needs and specification as criteria, the concept involving tubes with both sides open has been selected as the best idea. In order to simulate the performances of the collector, a model of the heat exchanges in an evacuated tube was developed in 4 steps. The first step is a model in steady state intended to calculate the stagnation temperature of the tube for a fixed solar radiation, outside temperature and wind speed. As a second step, the model is generalised to transient condition in order to validate it with an experimental setup. A root mean square error of 2% is then calculated. The two remainder steps are intended to calculate the temperature of airflow leaving the tube. In the same way, a first model in steady state is developed and then generalised to the transient mode. Then, the validation with an experimental setup gave a difference of 0.2% for the root mean square error. Finally, a preindustrial prototype intended to work in open loop for preheating of fresh air is presented. During the project, explosion of the both sides open evacuated tube in overheating condition blocked the construction of a real prototype for the test. Different path for further work are also identified. One of these is in relation with CFD simulation of the uniformity of the airflow inside of the collector. Another one is the analysis of the design with a design of experiment plan.

  19. The importance of liver microcirculation in promoting autoimmune hepatitis via maintaining an inflammatory cytokine milieu--a mathematical model study.

    PubMed

    Lettmann, Karsten Alexander; Hardtke-Wolenski, Matthias

    2014-05-01

    In autoimmune diseases, inflammatory cytokine concentrations are important for initiating and maintaining the status of autoimmunity. Autoimmune hepatitis (AIH) is an inflammatory liver disease characterized by a loss of immune tolerance against specific antigens located in hepatocytes. During the progression of the disease, antigen-presenting cells and different classes of T-helper cells secrete specific cytokines important for maintaining the disease. As these cytokines are secreted into the local liver environment, the blood flow in liver sinusoids might influence the local cytokine concentration. Considering the liver tissue as a porous medium, based on Darcy׳s law, the microcirculation within a liver lobule was modelled. Using realistic physiological pressure differences and tissue permeabilities, the blood velocity inside the sinusoids could be calculated and validated with blood velocity data obtained via Orthogonal Polarization Spectral Imaging (OPSI). Furthermore, oxygen consumption is modelled to obtain Rappaport׳s acinus model. Finally, steady state spatial distributions of secreted cytokines within the liver lobule could be estimated for specified realistic production rates of T-helper cells. It could be demonstrated that the characteristics of the liver microcirculation have an important impact on establishing inflammatory cytokine levels within the portal fields and the vascular septa promoting the occurrence of interface hepatitis.

  20. Workplace Literacy Pilot Projects: A Discussion Paper = Les Projects-pilotes en alphabetisation en milieu de travail: document de discussion.

    ERIC Educational Resources Information Center

    de Wolff, Alice

    From 1995-1998, 12 of the 79 organizations funded by Canada's National Literacy Secretariat (NLS) conducted approximately 40 workplace literacy pilot projects across Canada. Those projects were reviewed to determine their effectiveness in increasing the number and quality of Canadian workplace literacy programs. Information for the review was…

  1. La Belle Mort en Milieu Rural: a report of an ethnographic study of the good death for Quebec rural francophones.

    PubMed

    Veillette, Anne-Marie; Fillion, Lise; Wilson, Donna M; Thomas, Roger; Dumont, Serge

    2010-01-01

    An ethnographic study was undertaken in two rural areas of Quebec to conceptualize the good death. The findings reveal that a good quality of life for the dying person and his or her family and friends is essential for a good death. The resulting conceptual model emphasized four dimensions: physical, spiritual, social, and emotiona/psychological. These dimensions were determined to be similar to those discovered through a previous urban study, indicating that there may be considerable overlap between good deaths in rural and urban areas. Some findings of this Quebec French-language rural study were similar to those of an Alberta English-language rural study, indicating that rural people may have some common needs and interests with regard to the good death. As such, there could be some common elements of the good death that transcend culture or ethnicity. Chief among these is the desire of rural people to die at home or in their home communities.

  2. Content Knowledge in Teaching, an Investigation into an Adequate "Milieu" for Teaching Dance: The Case of Indian Dance in France

    ERIC Educational Resources Information Center

    Monique, Loquet; Malini, Ranganathan

    2010-01-01

    Since the 1970s, scientific researchers have shown that the nature and practice of the knowledge being taught plays an important role in the organization of teaching. Teaching content, first in mathematics, then in physical education, has become the object of scientific research in didactics in France. This research questions the commonplace…

  3. Benefices environnementaux de la cogeneration d'energie en milieu hospitalier et cas de l'Hopital de Moncton

    NASA Astrophysics Data System (ADS)

    Kone, Diakalia

    The present study aimed at assessing the environmental benefits of power management practices based on cogeneration in the particular industrial sector of hospitals and healthcare. Cogeneration power systems, also known as "Combined Heat and Power" (CHP) or Cogen, supply on-site electricity and heat from a single fuel source (natural gas in general). While the efficiency of conventional plants to produce power and heat separately is limited to about 30%, the efficiency of a CHP plant is close to 80% and can reach up to 90% in some applications (Borbely et Kreider, 2001). One of the distinctive features of hospitals is their continuous demand for both type of energy (electricity and heat), which makes them good candidate for cogeneration. However, in North America at the present time, less than 5% of hospitals run on CHP. Most are being supplied with electricity by conventional power plants, run by specialized companies, and use on-site boiler(s) to generate heat. Energy spending can reach up to 3% of an hospital's annual operational budget. There are also environmental impacts related to current energy supply and use in hospitals. For instance, the burning of fossil fuels releases greenhouse gases (GHG), which contribute to human health problems and climate change. The first objective of the study was to outline the main benefits and challenges faced by hospitals that aim at becoming their own energy co-generator, in comparison to having power and heat produced separately. Our second objective was to assess prospectively (proactively) the environmental impacts of a cogeneration plant that is being planned, but not yet operated, in a Canadian hospital. The methodology was based on literature reviews and on a case study, namely that of The Moncton Hospital (TMH)/L'Hopital de Moncton, Moncton, New Brunswick, Canada. This hospital is considered a large hospital with 375 beds and a major and expanding ambulatory care service. It is also in the process of developing a 1.06 MW cogeneration plant, to be run on natural gas, to meet about 30% of the facility's current demand for electricity and heat. In order to anticipate the environmental consequences of this CHP project, an environmental impact assessment (EIA) was conducted, according to the principles that apply in New Brunswick (Regulation 87-83 on EIA). A literature review was conducted and a matrix approach (matrix of impacts) was used to identify and assess the anticipated environmental impacts. The study showed that multiple stakeholders in the healthcare sector can reap benefits of CHP deployment. Facility owners can reduce energy costs and increase power reliability to enhance operations' continuity, during normal and extraordinary times (e.g., natural disasters). For instance, when hurricanes Katrina and Rita struck the United States in 2005, hospitals running with CHP were able to provide secure electricity supplies for emergency facilities and shelters. CHP also has environmental benefits related to its distinctively high efficiency. But its deployment in the healthcare sector also provides challenges, mainly due to the fact that power production is not a core activity for an hospital. These challenges can be overcome, however, as shown by numerous success stories in hospitals worldwide; specialised resources are available to help hospitals switch to CHP. This study underlines some of the steps a hospital can take toward this aim. EIA of The Moncton Hospital CHP project suggests that, globally, the environmental impacts of CHP are reduced compared to the traditional production of electricity and heat separately. Cogeneration utilizes fewer resources (fuel) and therefore releases fewer GHG and other pollutants. However, quantifying the emissions avoided is challenging. Also, the environmental benefits of CHP may be less obvious when compared to a centralised nuclear or hydraulic power production, which emits less GHG than power plants operating on coal or fuel oil. The study also indicates that other conditions are required to increase the environmental gai

  4. Improvements in the metabolic milieu following Roux-en-Y gastric bypass and the arrest of diabetic kidney disease.

    PubMed

    Docherty, Neil G; le Roux, Carel W

    2014-09-01

    Roux-en-Y gastric bypass (RYGB) is an efficacious intervention for morbid obesity and has a diabetes-remitting effect in patients with obesity and type 2 diabetes mellitus, which occurs prior to significant weight loss. Roux-en-Y gastric bypass is also associated with early and sustained reductions in the risk factor profile for the progression of diabetic complications. Attention is therefore now being placed on RYGB as a metabolic intervention with the capacity to yield therapeutic benefit in relation to the progression of diabetic complications, such as diabetic kidney disease. As alterations in gut anatomy following RYGB coincide with attendant shifts in downstream enteroendocrine signals with direct and indirect resolutionary effects on the kidney, the concept of an endocrine gut-kidney axis post-RYGB is growing. With the model of a gut-kidney axis in mind, this article summarizes emerging data on the effects of RYGB on risk factors for diabetic kidney disease (hyperglycaemia, dyslipidaemia and hypertension), highlighting a potential role for glucagon-like peptide 1 in risk factor reduction. PMID:25085842

  5. Immigrants living in an urban milieu with sanitation in Southern Italy: persistence and transmission of intestinal parasites.

    PubMed

    Gualdieri, Luciano; Piemonte, Monica; Alfano, Settimia; Maffei, Rita; Della Pepa, Maria Elena; Rinaldi, Laura; Galdiero, Marilena; Galdiero, Massimiliano; Cringoli, Giuseppe

    2016-03-01

    In the current era of globalization, the massive movement of populations to developed countries causes a greater attention to neglected tropical diseases in places where such diseases are considered unusual. The present study was planned to assess the persistence of intestinal parasitosis in immigrants stably living in the urban central area of Naples (Southern Italy) and the spread of infection within households with a lifestyle similar to that of the country of origin. A total of 2150 stool samples were analysed with the FLOTAC dual technique, and 415 subjects (19.3 %) tested positive for pathogenic intestinal parasites. One hundred ninety-six subjects were randomly selected and monitored again after 1 year in order to evaluate the persistence of intestinal parasites in immigrants having access to proper sanitation. No pathogenic parasites were found in these 196 samples. A total of 482 cohabitants of 151 positive subjects were recruited to evaluate the interfamilial spread of the identified parasites. Only in 18 households were there subjects infected with the same parasite. Monitoring of parasites in stool samples of immigrants showed a decrease of almost all pathogenic species over the years. From the analysis of households, it is not possible to assert that there is a familial transmission. Our study provides evidence that the prevalence of parasitic infections in immigrants is likely related to the poor sanitary habits of the country of origin and that acquisition of new sanitary regulations, together with the administration of pharmacological treatment, limits the transmission in the households and in the local population of their destination. PMID:26706907

  6. Age-related switch of bone mass in p47phox deficient mice through increased inflammatory milieu in bone

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Bone remodeling is age-dependently regulated and changes dramatically during the course of development. Excessive accumulation of reactive oxygen species (ROS), including superoxide, hydrogen peroxide, and hydroxyl radicals, has been suggested to be the leading cause of many inflammatory and degener...

  7. Caracterisation de l'effet du vieillissement en milieu aqueux sur les proprietes mecaniques de composites a matrice elastomere

    NASA Astrophysics Data System (ADS)

    Favre, Audrey

    Rubber composites are widely used in several engineering fields, such as automotive, and more recently for inflatable dams and other innovative underwater applications. These rubber materials are composed by an elastomeric matrix while the reinforcing phase is a synthetic fabric. Since these components are expected to operate several years in water environment, their durability must be guaranteed. The use of rubber materials immersed in water is not new, in fact, these materials have been studied for almost one century. However, the knowledge on reinforced rubber composites immersed several years in water is still limited. In this work, investigations on reinforced rubbers were carried out in the framework of a research project in partnership with Alstom and Hydro-Quebec. The objective of this study was to identify rubber composites that could be used under water for long periods. Various rubber composites with ethylene-propylene-diene monomer (EPDM), silicone, EPDM/silicone and polychloroprene (Neoprene) matrices reinforced with E-glass fabric were studied. Thus, these materials were exposed to an accelerated ageing at 85 °C underwater for periods varying from 14 to 365 days. For comparison purposes, they were also immersed and aged one year at room temperature (21 °C). The impact of accelerated aging was estimated through three different characterization methods. Scanning electron microscopy (SEM) was first used to assess the quality of fiber-matrix interface. Then, water absorption tests were performed to quantify the rate of water absorption during immersion. Finally the evolution of the mechanical properties was followed by the determination of Young's modulus (E) and ultimate stress (sigmau) using a dedicated traction test. This analysis allowed to point out that the quality of the fiber-matrix interface was the main factor influencing the drop of the mechanical properties and their durability. Moreover, it was noticed that this interface could be improved by using appropriate coupling agent as confirmed by the silicone composite with treated fabric. It was also observed that fiber-matrix interface could be a place where high stresses were localized because of differential swelling leading to an important loss of mechanical properties. The results revealed very different behaviors from one composite to another. The accelerated aging of EPDM/silicone and Neoprene composites led to a rapid diminution of mechanical properties in only 14 days. Conversely, silicone composites showed a 20 % increase of mechanical properties after 75 days of immersion. EPDM composites exhibited an important variability from one sample to another. It can be concluded from this study that composites made from silicone matrix with treated E-glass result in a better durability underwater. Keywords: composite elastomer, accelerated ageing, immersion in the water

  8. Metabolic surgery: action via hormonal milieu changes, changes in bile acids or gut microbiota? A summary of the literature

    PubMed Central

    Sweeney, Timothy E.; Morton, John M.

    2015-01-01

    Obesity and type 2 diabetes remain epidemic problems. Different bariatric surgical techniques causes weight loss and diabetes remission to varying degrees. The underlying mechanisms of the beneficial effects of bariatric surgery are complex, and include changes in diet and behavior, as well as changes in hormones, bile acid flow, and gut bacteria. We summarized the effects of multiple different bariatric procedures, and their resulting effects on several hormones (leptin, ghrelin, adiponectin, glucagon-like peptide 1 (GLP-1), peptide YY, and glucagon), bile acid changes in the gut and the serum, and resulting changes to the gut microbiome. As much as possible, we have tried to incorporate multiple studies to try to explain underlying mechanistic changes. What emerges from the data is a picture of clear differences between restrictive and metabolic procedures. The latter, in particular the roux-en-Y gastric bypass, induces large and distinctive changes in most measured fat and gut hormones, including early and sustained increase in GLP-1, possible through intestinal bile acid signaling. The changes in bile flow and the gut microbiome are causally inseparable so far, but new studies show that each contributes to the effects of weight loss and diabetes resolution. PMID:25194186

  9. Ontogenese de certains aspects de l'orientation du grillon des bois Nemobius sylvestris (Bosc), dans son milieu naturel.

    PubMed

    Beugnon, G; Mieulet, F; Campan, R

    1983-03-01

    The ontogeny of the orientation of the wood-cricket, Nemobius sylvestris, was studied experimentally in a variety of biotopes. In each experimental situation, the straightness of the routes taken by crickets improves with age. These results demonstrate that, depending on the variety of the constraints within each living area, various local individual solutions to the problem of orientation develop during ontogeny.

  10. The Motivational Determinants of Task Performance in a Non-Industrial Milieu: A Modification and Extension of Vroom's Model.

    ERIC Educational Resources Information Center

    Mendel, Raymond M.; Dickinson, Terry L.

    Vroom's cognitive model, which proposes to both explain and predict an individual's level of work productivity by drawing on the construct motivation, is discussed and three hypotheses generated: (1) that Vroom's model does predict performance in a non-industrial setting; (2) that it predicts self-perceived performance better than measures…

  11. Shedding PEG Palisade by Temporal Photostimulation and Intracellular Reducing Milieu for Facilitated Intracellular Trafficking and DNA Release.

    PubMed

    Wang, Tieyan; Chen, Qixian; Lu, Hongguang; Li, Wei; Li, Zaifen; Ma, Jianbiao; Gao, Hui

    2016-08-17

    The dilemma of poly(ethylene glycol) surface modification (PEGylation) inspired us to develop an intracellularly sheddable PEG palisade for synthetic delivery systems. Here, we attempted to conjugate PEG to polyethylenimine (PEI) through tandem linkages of disulfide-bridge susceptible to cytoplasmic reduction and an azobenzene/cyclodextrin inclusion complex responsive to external photoirradiation. The subsequent investigations revealed that facile PEG detachment could be achieved in endosomes upon photoirradiation, consequently engendering exposure of membrane-disruptive PEI for facilitated endosome escape. The liberated formulation in the cytosol was further subjected to complete PEG detachment relying on disulfide cleavage in the reductive cytosol, thus accelerating dissociation of electrostatically assembled PEI/DNA polyplex to release DNA by means of polyion exchange reaction with intracellularly charged species, ultimately contributing to efficient gene expression. PMID:27453033

  12. Glucagon-Like Peptide-1 as Predictor of Body Mass Index and Dentate Gyrus Neurogenesis: Neuroplasticity and the Metabolic Milieu

    PubMed Central

    Coplan, Jeremy D.; Perera, Tarique D.; Fulton, Sasha L.; Banerji, Mary Ann; Dwork, Andrew J.; Kral, John G.

    2014-01-01

    Glucagon-like peptide-1 (GLP-1) regulates carbohydrate metabolism and promotes neurogenesis. We reported an inverse correlation between adult body mass and neurogenesis in nonhuman primates. Here we examine relationships between physiological levels of the neurotrophic incretin, plasma GLP-1 (pGLP-1), and body mass index (BMI) in adolescence to adult neurogenesis and associations with a diabesity diathesis and infant stress. Morphometry, fasting pGLP-1, insulin resistance, and lipid profiles were measured in early adolescence in 10 stressed and 4 unstressed male bonnet macaques. As adults, dentate gyrus neurogenesis was assessed by doublecortin staining. High pGLP-1, low body weight, and low central adiposity, yet peripheral insulin resistance and high plasma lipids, during adolescence were associated with relatively high adult neurogenesis rates. High pGLP-1 also predicted low body weight with, paradoxically, insulin resistance and high plasma lipids. No rearing effects for neurogenesis rates were observed. We replicated an inverse relationship between BMI and neurogenesis. Adolescent pGLP-1 directly predicted adult neurogenesis. Two divergent processes relevant to human diabesity emerge—high BMI, low pGLP-1, and low neurogenesis and low BMI, high pGLP-1, high neurogenesis, insulin resistance, and lipid elevations. Diabesity markers putatively reflect high nutrient levels necessary for neurogenesis at the expense of peripheral tissues. PMID:25506432

  13. Versatile redox chemistry complicates antioxidant capacity assessment: flavonoids as milieu-dependent anti- and pro-oxidants.

    PubMed

    Chobot, Vladimir; Kubicova, Lenka; Bachmann, Gert; Hadacek, Franz

    2013-06-04

    Some antioxidants have been shown to possess additional pro-oxidant effects. Diverse methodologies exist for studying redox properties of synthetic and natural chemicals. The latter are substantial components of our diet. Exploration of their contribution to life-extending or -compromising effects is mandatory. Among reactive oxygen species (ROS), hydroxyl radical (•OH) is the most damaging species. Due to its short half-life, the assay has to contain a specific generation system. Plants synthesize flavonoids, phenolic compounds recognized as counter-agents to coronary heart disease. Their antioxidant activities are affected by their hydroxylation patterns. Moreover, in the plant, they mainly occur as glycosides. We chose three derivatives, quercetin, luteolin, and rutin, in attempts to explore their redox chemistry in contrasting hydrogen peroxide environments. Initial addition of hydrogen peroxide in high concentration or gradual development constituted a main factor affecting their redox chemical properties, especially in case of quercetin. Our study exemplifies that a combination of a chemical assay (deoxyribose degradation) with an electrochemical method (square-wave voltammetry) provides insightful data. The ambiguity of the tested flavonoids to act either as anti- or pro-oxidant may complicate categorization, but probably contributed to their evolution as components of a successful metabolic system that benefits both producer and consumer.

  14. Immigrants living in an urban milieu with sanitation in Southern Italy: persistence and transmission of intestinal parasites.

    PubMed

    Gualdieri, Luciano; Piemonte, Monica; Alfano, Settimia; Maffei, Rita; Della Pepa, Maria Elena; Rinaldi, Laura; Galdiero, Marilena; Galdiero, Massimiliano; Cringoli, Giuseppe

    2016-03-01

    In the current era of globalization, the massive movement of populations to developed countries causes a greater attention to neglected tropical diseases in places where such diseases are considered unusual. The present study was planned to assess the persistence of intestinal parasitosis in immigrants stably living in the urban central area of Naples (Southern Italy) and the spread of infection within households with a lifestyle similar to that of the country of origin. A total of 2150 stool samples were analysed with the FLOTAC dual technique, and 415 subjects (19.3 %) tested positive for pathogenic intestinal parasites. One hundred ninety-six subjects were randomly selected and monitored again after 1 year in order to evaluate the persistence of intestinal parasites in immigrants having access to proper sanitation. No pathogenic parasites were found in these 196 samples. A total of 482 cohabitants of 151 positive subjects were recruited to evaluate the interfamilial spread of the identified parasites. Only in 18 households were there subjects infected with the same parasite. Monitoring of parasites in stool samples of immigrants showed a decrease of almost all pathogenic species over the years. From the analysis of households, it is not possible to assert that there is a familial transmission. Our study provides evidence that the prevalence of parasitic infections in immigrants is likely related to the poor sanitary habits of the country of origin and that acquisition of new sanitary regulations, together with the administration of pharmacological treatment, limits the transmission in the households and in the local population of their destination.

  15. MEK inhibition prevents tumour-shed transforming growth factor-β-induced T-regulatory cell augmentation in tumour milieu

    PubMed Central

    Hossain, Dewan M S; Panda, Abir K; Chakrabarty, Sreeparna; Bhattacharjee, Pushpak; Kajal, Kirti; Mohanty, Suchismita; Sarkar, Irene; Sarkar, Diptendra K; Kar, Santosh K; Sa, Gaurisankar

    2015-01-01

    Tumour progression is associated with immune-suppressive conditions that facilitate the escape of tumour cells from the regimen of immune cells, subsequently paralysing the host defence mechanisms. Induction of CD4+ CD25+ FoxP3+ T regulatory (Treg) cells has been implicated in the tumour immune escape mechanism, although the novel anti-cancer treatment strategies targeting Treg cells remain unknown. The focus of this study is to define the interaction between tumour and immune system, i.e. how immune tolerance starts and gradually leads to the induction of adaptive Treg cells in the tumour microenvironment. Our study identified hyperactivated mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) -signalling as a potential target for reversing Treg cell augmentation in breast cancer patients. In more mechanistic detail, pharmacological inhibitors of MEK/ERK signalling inhibited transforming growth factor-β (TGF-β) production in tumour cells that essentially blocked TGF-β-SMAD3/SMAD4-mediated induction of CD25/interleukin-2 receptor α on CD4+ T-cell surface. As a result high-affinity binding of interleukin-2 on those cells was prohibited, causing lack of Janus kinase 1 (JAK1)/JAK3-mediated signal transducer and activator of transcription 3 (STAT3)/STAT5 activation required for FoxP3 expression. Finally, for a more radical approach towards a safe MEK inhibitor, we validate the potential of multi-kinase inhibitor curcumin, especially the nano-curcumin made out of pure curcumin with greater bioavailability; in repealing tumour-shed TGF-β-induced Treg cell augmentation. PMID:25284464

  16. [Human African trypanosomiasis in the urban milieu: the example of Kinshasa, Democratic Republic if the Congo, in 1998 and 1999].

    PubMed

    Bilengue, C M; Meso, V K; Louis, F J; Lucas, P

    2001-01-01

    Human African trypanosomiasis is an essentially rural disease. Occurrence in urban areas is uncommon except in cities that reproduce rural conditions conducive to the survival of glossinidae, i.e., forest and water. This is the case in neighborhoods near the zoo in Brazzaville, People's Republic of the Congo and in the residual mangrove forest in Conakry, Guinea. In Kinshasa, Democratic Republic of the Congo, an average of 39 cases were reported annually from 1970 to 1995. This figure increased to 254 in 1996 and 226 in 1997. This sharp rise led authorities to organize screening operations in some neighborhoods of the capital city. Results documented 433 cases in 1998 and 912 cases in 1999. The highest prevalence was found in outlying areas. This finding was probably related to focus of screening in these locations and to the practice of market gardening on plots surrounding the city. Placement of 276 insect traps along the Ndjili River led to the capture of 42,231 glossinidae over a 4 month period. Taken together, these findings indicate that the conditions necessary for active disease transmission are now reunited and that priority should be given to intensifying screening operations and information campaigns to health care providers working in the city.

  17. Modelisation de l'interaction entre une impulsion laser ultrabreve et une nanostructure plasmonique en milieu aqueux

    NASA Astrophysics Data System (ADS)

    Boulais, Etienne

    There is still a limited understanding of the basic mechanisms and processes triggered by laser irradiation that lead to the damaging of the surrounding structures. In particular, there exists for the moment no complete modelling of the process that includes all potential sources of cellular damage, including temperature rise, plasma generation, pressure wave emission and vapor bubble formation. This thesis presents such a modelling, with the cell environment emulated by a much simpler aqueous medium. Water is used as its optical, mechanical and thermal characteristic are similar enough to the cell environment to enable the transposition of the results and tendencies observed in water to this medium. Modelling consists in a continuous medium based approach that uses coupled partial differential equations to simulate the nanostructure-water system's response to an ultrafast laser pulse. The time-dependant field distribution in the system is simulated using classical electromagnetic theory, while the temperature in the nanostructure is calculated using a two-temperature model. Generation and heating of a plasma in the nanostructure's vicinity from photoionization and impact ionization in the near-field, as well as from photothermal emission from the nanostructure at the metal interface are also included. This plasma locally modifies the refractive index, which alters the simulated optical response of the system. Energy relaxation from this plasma as well as heat conduction from the nanostructure's lattice transfer energy to the water, which dynamics and thermodynamics evolutions are simulated from hydrodynamic and energy conservation equations. Modelling is used for analyzing the interaction of a near-infrared ultrafast laser pulse (45 fs, 800 nm, 200 mJ/cm2) with two distinct systems : a 100nm gold nanoparticle and a 10x41 nm2 gold nanorod. The gold nanoparticle shows a plasmon resonance at a ˜550 nm wavelength, and is thus slightly off-resonance at the 800 nm irradiation wavelength. In opposition, the gold nanorod shows a plasmon resonance directly at 800 nm and is thus in-resonance at the irradiation wavelength. The system of tightly coupled time-dependant non-linear partial differential equations is solved in 3D using a finite-element method. The modelling shows the generation of vapor bubble around both systems, which maximal diameter and growth time are validated from spectroscopic measurements. Results show an important production of plasma in the nanostructure's near field, which fast relaxation heats rapidly the surrounding water, leading to the emission of strong pressure wave and to the formation of a vapor bubble. Simulations further demonstrate the crucial importance of the plasma in the cavitation mechanism. For both the nanoparticle and the nanorod, results show that most of the laser energy is indeed absorbed in the plasma surrounding the nanostructure rather than in the nanostructure itself. In particular, the energy absorbed in the nanoparticle is shown to be insufficient to induce the formation of a vapor bubble at 200 mJ/cm2, whereas such a bubble is experimentally observed. This is a major result of the thesis, as such a plasma-mediated plasmonic enhanced cavitation mechanism has never been reported in the literature. The existence of this plasma-mediated mechanism that does not rely on the particle extreme heating to initiate cavitation has important consequences on cell nanosurgery applications. Finally, based on the same modelling, we develop a simple and efficient method to evaluate the potential of specific nanostructures and irradiation parameters for cell nanosurgery. We introduce a performance factor based on minimizing the energy density deposited in the nanostructure to avoid fragmentation, while maximizing the overall energy deposited in the system, to enhance the production of vapor bubbles. Results predict off-resonance 175 nm gold nanoparticles to be best suited for near-infrared ultrafast laser cell nanosurgery using 45 fs pulses at a wavelength of 800 nm. They also confirm the low inte

  18. Immunoglobulin isotype isolated from human placental extract does not interfere in complement-mediated bacterial opsonization within the wound milieu

    PubMed Central

    Sharma, Kanika; Bhattacharyya, Debasish

    2015-01-01

    The wound healing potency of an aqueous extract of placenta can be evaluated through the presence of numerous regulatory components. The presence of glycans was detected by thin layer chromatography and fluorophore-assisted carbohydrate electrophoresis. Mass spectrometric analysis revealed the existence of multiple fragments of immunoglobulin G (IgG). IgG was present in the extract at a concentration of 25.2 ± 3.97 μg/ml. IgG possesses anti-complementary activity by diverting the complement activation from target surface. Thus, effect of placental IgG on complement–bacteria interaction was investigated through classical and alternative pathway and the preparation was ascertained to be safe with respect to their interference in the process of bacterial opsonization. PMID:25984442

  19. PolyICLC Exerts Pro- and Anti-HIV Effects on the DC-T Cell Milieu In Vitro and In Vivo.

    PubMed

    Aravantinou, Meropi; Frank, Ines; Hallor, Magnus; Singer, Rachel; Tharinger, Hugo; Kenney, Jessica; Gettie, Agegnehu; Grasperge, Brooke; Blanchard, James; Salazar, Andres; Piatak, Michael; Lifson, Jeffrey D; Robbiani, Melissa; Derby, Nina

    2016-01-01

    Myeloid dendritic cells (mDCs) contribute to both HIV pathogenesis and elicitation of antiviral immunity. Understanding how mDC responses to stimuli shape HIV infection outcomes will inform HIV prevention and treatment strategies. The long double-stranded RNA (dsRNA) viral mimic, polyinosinic polycytidylic acid (polyIC, PIC) potently stimulates DCs to focus Th1 responses, triggers direct antiviral activity in vitro, and boosts anti-HIV responses in vivo. Stabilized polyICLC (PICLC) is being developed for vaccine adjuvant applications in humans, making it critical to understand how mDC sensing of PICLC influences HIV infection. Using the monocyte-derived DC (moDC) model, we sought to describe how PICLC (vs. other dsRNAs) impacts HIV infection within DCs and DC-T cell mixtures. We extended this work to in vivo macaque rectal transmission studies by administering PICLC with or before rectal SIVmac239 (SIVwt) or SIVmac239ΔNef (SIVΔNef) challenge. Like PIC, PICLC activated DCs and T cells, increased expression of α4β7 and CD169, and induced type I IFN responses in vitro. The type of dsRNA and timing of dsRNA exposure differentially impacted in vitro DC-driven HIV infection. Rectal PICLC treatment similarly induced DC and T cell activation and pro- and anti-HIV factors locally and systemically. Importantly, this did not enhance SIV transmission in vivo. Instead, SIV acquisition was marginally reduced after a single high dose challenge. Interestingly, in the PICLC-treated, SIVΔNef-infected animals, SIVΔNef viremia was higher, in line with the importance of DC and T cell activation in SIVΔNef replication. In the right combination anti-HIV strategy, PICLC has the potential to limit HIV infection and boost HIV immunity. PMID:27603520

  20. Le milieu social des eleves et leurs chances de succes a l'ecole (The Social Background of Students and Their Chance of Success at School).

    ERIC Educational Resources Information Center

    1971

    This document is an English-language abstract (approximately 1,500 words) of a French report in response to an IBE questionnaire. Studies conducted by the Ministry of Information have revealed that particularly serious educational wastage has been taking place on both the elementary and secondary levels, and the French education system is not well…

  1. Transfer of Learning: Planning Effective Workplace Education Programs = Transfert d'apprentissage: La Planification de programmes d'education efficaces en milieu de travail.

    ERIC Educational Resources Information Center

    Taylor, Maurice

    Given the centrality of the topic of transfer of learning to so many areas of workplace education, this discussion paper (in both English and French versions) draws together research results and practical techniques to help practitioners in the field. Part 1 defines transfer of learning. Part 2 describes factors that influence the transfer of…

  2. Consequences experimentales des effets des fluctuations du vide sur la fluorescence parametrique et la generation du second harmonique en milieu confine

    NASA Astrophysics Data System (ADS)

    Robichaud, Luc

    Les fluctuations du vide, qui consistent en l'apparition momentanee de particules, ce qui est permit par le principe d'incertitude de Heisenberg, joue un role primordial dans les processus photoniques, en particulier les processus non-lineaires. Par la manipulation de ces fluctuations du vide a l'aide de confinement optique, on retrouve deux phenomenes particuliers : l'intensification de la fluorescence parametrique (Walker, 2008) et l'inhibition de la generation du second harmonique (Collette, 2013). Dans ce travail, on presente les resultats dans le cas classique ; c'est-a-dire sans fluctuations du vide et confinement. Par la suite, on presente les effets des fluctuations du vide et du confinement, ce qui mene aux deux effets mentionnes. Dans le cas de la fluorescence parametrique, le bruit quantique sur le champ interne et externe est calcule, le role du desaccord de phase dans le modele est expose et une generalisation tridimensionnelle est etudiee afin de generaliser la conception du modele d'un cas unidimensionnel a un cas tridimensionnel planaire. Dans le cas de la generation du second harmonique, les difficultes d'un modele purement tridimensionnel sont exposees et ensuite le cas limite planaire est etudie.

  3. Transmission quantique de clés de cryptage en milieu aérien par codage en phase de bandes latérales de modulation

    NASA Astrophysics Data System (ADS)

    Marc, M.; Mérolla, J.-M.; Durrafourg, L.; Goedgebuer, J.-P.; Rhodes, W. T.

    2002-06-01

    L'étude présentée concerne un procédé de distribution quantique de clés de cryptage utilisant des états cohérents et la mise au point d'un système de transmission aérien. Le système de cryptage exploite les propriétés d'interférence à un photon dans deux bandes latérales de modulation, qui contiennent chacune en moyenne 0,1 photon. Les probabilités de détecter un photon dans chacune des bandes de modulation varient de façon complémentaire en fonction du déphasage induit entre l'émetteur et le récepteur. Cette méthode permet d'exploiter le protocole à 4 états de distribution de clé.

  4. Stimulating Milieu to Learning and Teaching at Today's Czech Schools: A Contribution to the Recognition of the Culture of an Essential School Process

    ERIC Educational Resources Information Center

    Pol, Milan; Lenka, Hlouskova; Novotny, Petr; Zounek, Jiri

    2003-01-01

    This contribution deals with the most important area of school operation, the learning and teaching environment. Several weighty circumstances of its functioning are herewith examined, such as the operation of the school as a manifestation of its culture, the relation between learning and teaching, and paradigms of the school as specific…

  5. Recherches Sur La Psychologie de L'enfant de Milieu Defavorise. Rapport- synthese. (Research Relating to the Psychology of the Child in Disadvantaged Environments. Summary Report).

    ERIC Educational Resources Information Center

    Caouette, Charles E.; Bourbeau, Gerald

    Thirteen doctoral dissertations and five masters theses are summarized in this report of research on the disadvantaged child. Contained in each individual summary are the detailed descriptions of the experimental task, the results obtained and the analysis of these results. The eighteen individual theses are concerned with topics such as:…

  6. Morbidité et mortalité hospitalière des maladies cardiovasculaires en milieu tropical: exemple d'un centre hospitalier à Lomé (Togo)

    PubMed Central

    Damorou, Findibe; Baragou, Soodougoua; Pio, Machihuede; Afassinou, Yaovi M; N'da, N'kenon W; Pessinaba, Soulemane; Tchérou, Tchaa; Attiogbé, Halé; Ehlan, Koffi; Goeh-Akue, Edem; Yayehd, Komlavi

    2014-01-01

    Introduction Les maladies cardiovasculaires (MCV) occupent une place importante dans la mortalité en Afrique, situation inquiétante traduisant une transition épidémiologique rapide. La connaissance des groupes nosologiques les plus mortelles devrait aider à l’élaboration de politiques en matière de traitement et de prévention. Méthodes Il's agit d une étude rétrospective du 1er janvier 2006 au 31 décembre 2010, ayant inclus les patients hospitalisés pour une MCV selon la classification Internationale des maladies (CIM-10). Résultats La fréquentation hospitalière pour maladie MCV a augmenté au fil du temps; les maladies hypertensives étaient le premier motif d hospitalisation (66.8%). Les autres pathologies fréquentes étaient la maladie thromboembolique (9.1%), les syndromes coronaires aigus (SCA) (7.3%), l'insuffisance cardiaque (5.5%), les cardiomyopathies (5.3%). La majorité des sujets étaient jeunes (âge moyen: 55.1 ans) et il n'y avait pas de corrélation entre la durée d'hospitalisation et l’âge: r = + 0.024, p = 0.09. La mortalité globale était élevée (11%) et les taux de létalité élevés dans le SCA (27.9%), l'embolie pulmonaire (25%) et la péricardite (25%). Conclusion Les MCV sont responsables d'une hospitalisation croissante dans nos hôpitaux. L'absence d unité de soins intensifs cardiologiques et des méthodes de revascularisation coronaire, le manque de personnels qualifiés associés l'inexistence de sécurité sociale expliquent une mortalité élevée dans nos pays en voie de développement qui sans avoir achevé leur transition démographique entre en pleine transition épidémiologique. PMID:25018812

  7. Prevalence of Antimicrobial Resistant and Virulent Salmonella spp. in Treated Effluent and Receiving Aquatic Milieu of Wastewater Treatment Plants in Durban, South Africa.

    PubMed

    Odjadjare, Ejovwokoghene C; Olaniran, Ademola O

    2015-08-01

    In this study, we evaluated the impact of treated wastewater effluent from two wastewater treatment plants on the physicochemical parameters and Salmonella spp. load of receiving rivers. Presumptive Salmonella spp. were obtained at all sampled points including the discharge points, with counts ranging from 0 to 4.14 log cfu/mL at both plants. Turbidity, chemical and biological oxygen demand were found to be high and mostly above the required limit for treated wastewater discharge. However, recorded nitrate and phosphate values were very low. Of the 200 confirmed Salmonella spp. isolates recovered from the treated effluent and receiving surface waters, 93% harbored the spiC gene, 84% harbored the misL gene, and 87.5% harbored the orfL gene while 87% harbored the pipD gene. The antibiotic resistance profile revealed that the isolates were resistant to sulfamethoxazole, nalidixic acid and streptomycin, but susceptible to quinolones and third generation β-lactams. These results indicate that in South Africa treated effluents are still a major source of contamination of rivers with pathogens such as Salmonella. Appropriate steps by the regulatory authorities and workers at the treatment plants are needed to enforce stipulated guidelines in order to prevent pollution of surface water resources due to the discharge of poorly treated effluents. PMID:26295245

  8. Examining Mandated Testing, Teachers' Milieu, "and" Teachers' Knowledge and Beliefs: Gaining a Fuller Understanding of the Web of Influence on Teachers' Classroom Practices

    ERIC Educational Resources Information Center

    Neumann, Jacob W.

    2016-01-01

    Background: Much research has been done on the factors that influence teachers' work. Yet, the nature and scope of those factors, and their impact on teachers, remain unclear. Indeed, different literature bases on teachers' work present different and often contradictory conclusions. For example, some researchers claim that mandated accountability…

  9. Bovine colostrum increases pore-forming claudin-2 protein expression but paradoxically not ion permeability possibly by a change of the intestinal cytokine milieu.

    PubMed

    Bodammer, Peggy; Kerkhoff, Claus; Maletzki, Claudia; Lamprecht, Georg

    2013-01-01

    An impaired intestinal barrier function is involved in the pathogenesis of inflammatory bowel disease (IBD). Several nutritional factors are supposed to be effective in IBD treatment but scientific data about the effects on the intestinal integrity remain scarce. Bovine colostrum was shown to exert beneficial effects in DSS-induced murine colitis, and the present study was undertaken to explore the underlying molecular mechanisms. Western blot revealed increased claudin-2 expression in the distal ileum of healthy mice after feeding with colostrum for 14 days, whereas other tight junction proteins (claudin-3, 4, 10, 15) remained unchanged. The colostrum-induced claudin-2 induction was confirmed in differentiated Caco-2 cells after culture with colostrum for 48 h. Paradoxically, the elevation of claudin-2, which forms a cation-selective pore, was neither accompanied by increased ion permeability nor impaired barrier function. In an in situ perfusion model, 1 h exposure of the colonic mucosa to colostrum induced significantly increased mRNA levels of barrier-strengthening cytokine transforming growth factor-β, while interleukine-2, interleukine-6, interleukine-10, interleukine-13, and tumor-necrosis factor-α remained unchanged. Thus, modulation of the intestinal transforming growth factor-β expression might have compensated the claudin-2 increase and contributed to the observed barrier strengthening effects of colostrum in vivo and in vitro. PMID:23717570

  10. Bovine Colostrum Increases Pore-Forming Claudin-2 Protein Expression but Paradoxically Not Ion Permeability Possibly by a Change of the Intestinal Cytokine Milieu

    PubMed Central

    Maletzki, Claudia; Lamprecht, Georg

    2013-01-01

    An impaired intestinal barrier function is involved in the pathogenesis of inflammatory bowel disease (IBD). Several nutritional factors are supposed to be effective in IBD treatment but scientific data about the effects on the intestinal integrity remain scarce. Bovine colostrum was shown to exert beneficial effects in DSS-induced murine colitis, and the present study was undertaken to explore the underlying molecular mechanisms. Western blot revealed increased claudin-2 expression in the distal ileum of healthy mice after feeding with colostrum for 14 days, whereas other tight junction proteins (claudin-3, 4, 10, 15) remained unchanged. The colostrum-induced claudin-2 induction was confirmed in differentiated Caco-2 cells after culture with colostrum for 48 h. Paradoxically, the elevation of claudin-2, which forms a cation-selective pore, was neither accompanied by increased ion permeability nor impaired barrier function. In an in situ perfusion model, 1 h exposure of the colonic mucosa to colostrum induced significantly increased mRNA levels of barrier-strengthening cytokine transforming growth factor-β, while interleukine-2, interleukine-6, interleukine-10, interleukine-13, and tumor-necrosis factor-α remained unchanged. Thus, modulation of the intestinal transforming growth factor-β expression might have compensated the claudin-2 increase and contributed to the observed barrier strengthening effects of colostrum in vivo and in vitro. PMID:23717570

  11. Structure and stability of recombinant bovine odorant-binding protein: III. Peculiarities of the wild type bOBP unfolding in crowded milieu.

    PubMed

    Stepanenko, Olga V; Roginskii, Denis O; Stepanenko, Olesya V; Kuznetsova, Irina M; Uversky, Vladimir N; Turoverov, Konstantin K

    2016-01-01

    Contrary to the majority of the members of the lipocalin family, which are stable monomers with the specific OBP fold (a β-barrel consisting of a 8-stranded anti-parallel β-sheet followed by a short α-helical segment, a ninth β-strand, and a disordered C-terminal tail) and a conserved disulfide bond, bovine odorant-binding protein (bOBP) does not have such a disulfide bond and forms a domain-swapped dimer that involves crossing the α-helical region from each monomer over the β-barrel of the other monomer. Furthermore, although natural bOBP isolated from bovine tissues exists as a stable domain-swapped dimer, recombinant bOBP has decreased dimerization potential and therefore exists as a mixture of monomeric and dimeric variants. In this article, we investigated the effect model crowding agents of similar chemical nature but different molecular mass on conformational stability of the recombinant bOBP. These experiments were conducted in order to shed light on the potential influence of model crowded environment on the unfolding-refolding equilibrium. To this end, we looked at the influence of PEG-600, PEG-4000, and PEG-12000 in concentrations of 80, 150, and 300 mg/mL on the equilibrium unfolding and refolding transitions induced in the recombinant bOBP by guanidine hydrochloride. We are showing here that the effect of crowding agents on the structure and conformational stability of the recombinant bOBP depends on the size of the crowder, with the smaller crowding agents being more effective in the stabilization of the bOBP native dimeric state against the guanidine hydrochloride denaturing action. This effect of the crowding agents is concentration dependent, with the high concentrations of the agents being more effective. PMID:27114858

  12. Micellisation et activité de surface des bromures de n-alkyltriméthylammonium en milieu eau-acide orthophosphorique

    NASA Astrophysics Data System (ADS)

    Ouni, S.; Hafiane, A.; Dhahbi, M.

    1998-05-01

    Measurements of superficial tension of n-alkyltrimethylammonium bromides in air/water-orthophosphoric acid interface have been made by “stripping method". Data were evaluated by approximation to the Von Szyszkowski equation. Thermodynamic parameters as (Γmax, F, A, B, Δ G^circ_A, Δ GM and CMC) at different concentrations of orhophosphoric acid (0 at 3 M) are calculted. The CMC values of the homologous series in relation to the chain length were determined. They showed a good correlation with the Klevens equation. A minimum of CMC and (-ΔGM) was observed for the n-octadecyltrimethylammonium bromide, which has been attributed to the cosolvant effect and the change of medium properties. L'adsorption, de bromure de n-alkyltriméthylammonium à l'interface air/eau-acide orthophosphorique, a été étudiée par la mesure de tension superficielle en fonction du nombre d'atomes de carbone du groupement alkyle et de la concentration en acide orthophosphorique (0 à 3 M). L'analyse des résultats a été effectuée à l'aide de l'équation de Von Szyszkowski. Les grandeurs et paramètres thermodynamiques (Γmax, F, A, B, Δ G^circ_A, Δ GM and CMC) ont été déterminés et discutés selon l'équilibre de forces de répulsion électrostatique entre les têtes polaires et d'attraction hydrophobe des chaînes aliphatiques. Les valeurs des CMC obéissent à l'équation de Klevens. Dans le cas du bromure de n-octadécyltriméthylammonium les valeurs de la CMC et de (-ΔGM) présentent un minimum, attribué au changement des propriétés du binaire eau-acide orthophosphorique.

  13. The value of purpose built mental health facilities: Use of the Ward Atmosphere Scale to gauge the link between milieu and physical environment.

    PubMed

    Nicholls, Daniel; Kidd, Kevin; Threader, Jennifer; Hungerford, Catherine

    2015-08-01

    This study investigated changes in the 'atmosphere' of an acute adult mental health setting following relocation to a new purpose-built facility. The Ward Atmosphere Scale (WAS) was designed and validated for specific use in hospital-based psychiatric facilities, and measures several dimensions of an environment. In this study, the WAS was administered to consumers and staff at periods before and also after their relocation to a new purpose-built acute adult mental health facility. There were significant improvements in the physical atmosphere of the new facility, when compared with the old facility. In terms of ward atmosphere, however, improvements were seen to occur in only a small number of measures and there were minor differences between consumers' and staff perspectives on some indicators. Interestingly, it was found that consumers noted less 'staff control' in the new setting, raising the question of the differences in understanding of control. For staff only, there was a perception of greater levels of consumer 'involvement' in the new facility. Despite the minor differences in perception, the study does confirm that architecture is an important influence on the 'atmosphere' of a health facility, for both staff and consumers.

  14. Surpoids et obésité dans la population au-dessus de 20 ans en milieu urbain bamakois (Mali)

    PubMed Central

    Oumar Bâ, Hamidou; Menta, Ichaka; Camara, Youssouf; Sangaré, Ibrahima; Sidibé, Noumou; Doumbia, Seydou; Diarra, Mamadou Bocary

    2014-01-01

    Introduction Il est question dans notre travail d’étudier le SP et l'OB et les facteurs associés dans la population âgée de 20 ans ou plus. Méthodes Notre échantillon a été obtenu à partir d'une enquête sur les pathologies cardiovasculaires dans le District de Bamako et impliquant 2199 sujets de 5-104 ans, en sélectionnant tous les sujets âgés d'au moins 20 ans (1162). Pour chaque sujet, l'IMC, rapport taille / hanche et le tour de taille ont été déterminées. Les données ont été analysées avec SPSS 12. Résultats L’âge moyen était de 36,86 années, 61,4% étaient des femmes, 49,7% dans le secteur informel et 38,0% avaient réalisé l'enseignement primaire. Facteurs de risque cardiovasculaires étaient l'inactivité physique (72,4%), le tabagisme (12,2%) et hypertension (26,7%). La prévalence de l'obésité était de 8,8 et 14,7% respectivement sur la base de l'indice de masse et le tour de taille. Conclusion Le SP et l'OB sont à prendre en compte dans les mesures de politique sanitaire que dans la pratique quotidienne des professionnels de santé, il est peut-être plus utile d'utiliser plusieurs paramètres pour être à même de bien stratifier nos patients par rapport à leur risque. PMID:25932065

  15. A buffer value index to evaluate effects of buffers on ruminal milieu in cows fed high or low concentrate, silage, or hay diets.

    PubMed

    Tucker, W B; Hogue, J F; Aslam, M; Lema, M; Martin, M; Owens, F N; Shin, I S; Le Ruyet, P; Adams, G D

    1992-03-01

    Our objective was to develop a buffer value index that would incorporate alterations in both ruminal fluid pH and buffering capacity as indicators of the influence of dietary buffering and alkalinizing agents on ruminal acid-base status. This index was evaluated using ruminal fluid from four lactating Holstein cows fed either sorghum silage or alfalfa hay in high or low concentrate diets. Ruminal fluid was incubated in vitro for 1, 2, 3, 4, or 5 h with no buffer or with 7.1 g of either NaHCO3, sodium sesquicarbonate, or a multielement buffer added per liter of ruminal fluid. Ruminal fluid pH was lower for diets based on high concentrate or alfalfa; buffering capacity between pH 5 and 7 was greater for high concentrate diets but was not affected by forage type. Ruminal fluid pH was higher for sesquicarbonate than for NaHCO3, the multielement buffer, or the control; however, ruminal fluid H+ concentration was similar between sesquicarbonate and NaHCO3, and both were lower than for the multielement buffer. Hydrogen ion concentration for the multielement buffer was lower than for the control. Buffering capacity was highest for NaHCO3, followed by sesquicarbonate, the multielement buffer, and the control. The buffer value index, which accounted for alterations in both H+ concentration and buffering capacity, was highest for NaCHO3, followed by sesquicarbonate, the multielement buffer, and the control. The poor response to the multielement buffer may be attributable to our relatively short incubation interval (less than 5 h). Dietary buffers increase both ruminal fluid pH and buffering capacity; both of these responses are beneficial.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:1314858

  16. The Moral Milieu of Information Technology: Using Domain and Affordance Theory to Explain Situational and Technological Effects on Ethical IT Decision Making

    ERIC Educational Resources Information Center

    Schilhavy, Richard Arthur Milton

    2012-01-01

    Unethical behavior in the use of IT may result in significant negative impacts on the productivity, profitability, and reputation of the organization. IT exacerbates moral problems through its constant evolution, multi-faceted nature and encroachment into our personal and professional lives. People have difficulty recognizing moral…

  17. Municipal Wastewater Effluents as a Source of Listerial Pathogens in the Aquatic Milieu of the Eastern Cape Province of South Africa: A Concern of Public Health Importance

    PubMed Central

    Odjadjare, Emmanuel E.O.; Obi, Larry C.; Okoh, Anthony I.

    2010-01-01

    We evaluated the effluent quality of an urban wastewater treatment facility in South Africa and its impact on the receiving watershed for a period of 12 months. The prevalence and antimicrobial susceptibility of potential Listeria pathogens (L. ivanovii and L. innocua) and the physicochemical quality of the treated wastewater effluent was assessed, with a view to ascertain the potential health and environmental hazards of the discharged effluent. Total listerial density varied between 2.9 × 100 and 1.2 × 105 cfu/mL; free living Listeria species were more prevalent (84%), compared to Listeria species attached to planktons (59–75%). The treated effluent quality fell short of recommended standards for turbidity, dissolved oxygen, chemical oxygen demand, nitrite, phosphate and Listeria density; while pH, temperature, total dissolved solids and nitrate contents were compliant with target quality limits after treatment. The Listeria isolates (23) were sensitive to three (15%) of the 20 test antibiotics, and showed varying (4.5–91%) levels of resistance to 17 antibiotics. Of seven resistance gene markers assayed, only sulII genes were detected in five (22%) Listeria strains. The study demonstrates a potential negative impact of the wastewater effluent on the receiving environment and suggests a serious public health implication for those who depend on the receiving watershed for drinking and other purposes. PMID:20623030

  18. Structure and stability of recombinant bovine odorant-binding protein: III. Peculiarities of the wild type bOBP unfolding in crowded milieu

    PubMed Central

    Stepanenko, Olga V.; Roginskii, Denis O.; Stepanenko, Olesya V.; Kuznetsova, Irina M.

    2016-01-01

    Contrary to the majority of the members of the lipocalin family, which are stable monomers with the specific OBP fold (a β-barrel consisting of a 8-stranded anti-parallel β-sheet followed by a short α-helical segment, a ninth β-strand, and a disordered C-terminal tail) and a conserved disulfide bond, bovine odorant-binding protein (bOBP) does not have such a disulfide bond and forms a domain-swapped dimer that involves crossing the α-helical region from each monomer over the β-barrel of the other monomer. Furthermore, although natural bOBP isolated from bovine tissues exists as a stable domain-swapped dimer, recombinant bOBP has decreased dimerization potential and therefore exists as a mixture of monomeric and dimeric variants. In this article, we investigated the effect model crowding agents of similar chemical nature but different molecular mass on conformational stability of the recombinant bOBP. These experiments were conducted in order to shed light on the potential influence of model crowded environment on the unfolding-refolding equilibrium. To this end, we looked at the influence of PEG-600, PEG-4000, and PEG-12000 in concentrations of 80, 150, and 300 mg/mL on the equilibrium unfolding and refolding transitions induced in the recombinant bOBP by guanidine hydrochloride. We are showing here that the effect of crowding agents on the structure and conformational stability of the recombinant bOBP depends on the size of the crowder, with the smaller crowding agents being more effective in the stabilization of the bOBP native dimeric state against the guanidine hydrochloride denaturing action. This effect of the crowding agents is concentration dependent, with the high concentrations of the agents being more effective. PMID:27114858

  19. Surpoids et obésité dans la population générale de 5 à 19 ans en milieu urbain bamakois (Mali)

    PubMed Central

    Oumar Bâ, Hamidou; Menta, Ichaka; Camara, Youssouf; Doumbia, Plutôt Seydou; Diarra, Mamadou Bocary

    2014-01-01

    Introduction Déterminer la prévalence du surpoids et de l'obésité dans la population âgée de 5 à 19 ans et fournir des données de référence pour de futures études. Méthodes Notre échantillon est issu de la première étude sur les pathologies cardiovasculaires basée sur l'approche STEP de l'Organisation Mondiale de la Santé (OMS) en sélectionnant tous les sujets âgés de 5 à 19 ans. Nous avons utilisé les méthodes de l'OMS et de l'International Obesity Task Force (IOTF) pour déterminer la prévalence du surpoids et de l'obésité dans la population générale. Résultats La moyenne d’âge était de 11,75 ans ± 4,387 et le sex-ratio M:F était de 0,79. les moyennes pour le poids et la taille étaient de 36,85 kg et 143,48 cm. Selon les critères OMS 1,61% des garçons et 3,28% des filles étaient en surpoids et 0,92% des garçons contre 1,46% des filles obèses. Selon les critères de l'IOTF 4,10% des garçons et 5,94% des filles étaient en surpoids tandis que 0,72% des garçons et 2,68% des filles étaient obèses. Conclusion Malgré sa faible prévalence le surpoids et l'obésité doivent être régulièrement étudiés pour reconnaître des tendances et prendre des mesures adéquates de prévention. Les 2 méthodes utilisées ont permis d'avoir des données de référence pour de futures études au Mali et ailleurs. PMID:25932064

  20. Prevalence of Antimicrobial Resistant and Virulent Salmonella spp. in Treated Effluent and Receiving Aquatic Milieu of Wastewater Treatment Plants in Durban, South Africa

    PubMed Central

    Odjadjare, Ejovwokoghene C.; Olaniran, Ademola O.

    2015-01-01

    In this study, we evaluated the impact of treated wastewater effluent from two wastewater treatment plants on the physicochemical parameters and Salmonella spp. load of receiving rivers. Presumptive Salmonella spp. were obtained at all sampled points including the discharge points, with counts ranging from 0 to 4.14 log cfu/mL at both plants. Turbidity, chemical and biological oxygen demand were found to be high and mostly above the required limit for treated wastewater discharge. However, recorded nitrate and phosphate values were very low. Of the 200 confirmed Salmonella spp. isolates recovered from the treated effluent and receiving surface waters, 93% harbored the spiC gene, 84% harbored the misL gene, and 87.5% harbored the orfL gene while 87% harbored the pipD gene. The antibiotic resistance profile revealed that the isolates were resistant to sulfamethoxazole, nalidixic acid and streptomycin, but susceptible to quinolones and third generation β-lactams. These results indicate that in South Africa treated effluents are still a major source of contamination of rivers with pathogens such as Salmonella. Appropriate steps by the regulatory authorities and workers at the treatment plants are needed to enforce stipulated guidelines in order to prevent pollution of surface water resources due to the discharge of poorly treated effluents. PMID:26295245

  1. Who were his peers? The social and professional milieu of the provincial surgeon-apothecary in the late-eighteenth century.

    PubMed

    Tomkins, Alannah

    2011-01-01

    The social standing of the surgeon-apothecary cannot be determined by reference to professional life alone, yet few such men left social documents. The lower middling sort was typically reticent about evaluations of their own social position in any source genre. This article uses a unique archive, and the concept of community connectedness, to investigate the status of Thomas Higgins, surgeon-apothecary and man-midwife of north Shropshire. Higgins embodied the traditional practitioner who relied on local knowledge and his 'friends' for advancement, in contrast to alternative modes of rising professionalism. He was demonstrably a trusted man at the heart of his home town, but his reliance on the 'partiality' of his neighbors brought him into conflict with his colleagues. PMID:21853622

  2. Sex Role and Attitudes Toward Institutional Violence Among College Youth: The Impact of Sex-Role Identification, Parental Socialization, and Socio-Cultural Milieu.

    ERIC Educational Resources Information Center

    Starr, Jerold M.; Cutler, Neal E.

    Attitudinal differences between males and females on certain issues have been repeatedly documented through commercial public polls and academic studies. One of these differences is the greater reluctance on the part of females to support the use of institutional violence as an instrument of public policy. This paper empirically explores the…

  3. Prevalence of Antimicrobial Resistant and Virulent Salmonella spp. in Treated Effluent and Receiving Aquatic Milieu of Wastewater Treatment Plants in Durban, South Africa.

    PubMed

    Odjadjare, Ejovwokoghene C; Olaniran, Ademola O

    2015-08-18

    In this study, we evaluated the impact of treated wastewater effluent from two wastewater treatment plants on the physicochemical parameters and Salmonella spp. load of receiving rivers. Presumptive Salmonella spp. were obtained at all sampled points including the discharge points, with counts ranging from 0 to 4.14 log cfu/mL at both plants. Turbidity, chemical and biological oxygen demand were found to be high and mostly above the required limit for treated wastewater discharge. However, recorded nitrate and phosphate values were very low. Of the 200 confirmed Salmonella spp. isolates recovered from the treated effluent and receiving surface waters, 93% harbored the spiC gene, 84% harbored the misL gene, and 87.5% harbored the orfL gene while 87% harbored the pipD gene. The antibiotic resistance profile revealed that the isolates were resistant to sulfamethoxazole, nalidixic acid and streptomycin, but susceptible to quinolones and third generation β-lactams. These results indicate that in South Africa treated effluents are still a major source of contamination of rivers with pathogens such as Salmonella. Appropriate steps by the regulatory authorities and workers at the treatment plants are needed to enforce stipulated guidelines in order to prevent pollution of surface water resources due to the discharge of poorly treated effluents.

  4. Etude de quelques fonctionnelles du mouvement brownien et de certaines propriétés de la diffusion unidimensionnelle en milieu aléatoire

    NASA Astrophysics Data System (ADS)

    Monthus, Cécile

    This paper deals with functionals of Brownian motion that appear in various contexts, and with some properties of anomalous diffusion in a one-dimensional random environment. Section 2 explains why path integrals provide a powerful framework to compute probability distribution of functionals of Brownian motion. This approach is used to study winding properties of planar Brownian motion. Section 3 is devoted to an exponential functional of Brownian motion, which arise in particular in the study of transport properties of classical diffusion in a one-dimensional disordered system of finite length. This functional belongs to the field of multiplicative stochastic processes. Cet article porte sur l'étude des distributions de probabilité de quelques fonctionnelles du mouvement brownien qui interviennent dans divers contextes physiques. Le paragraphe 2 présente une méthode d'intégrale de chemin qui relieles distributions de probabilité de certaines fonctionnelles du mouvement brownien, à des fonctions de Green euclidiennes de la mécanique quantique. Cette approche permet notamment d'étudier certaines propriétés d'enroulementdu mouvement brownien plan, qu'il soit libre ou soumis à l'action d'un potentiel extérieur. Les fonctions d'échelle et les formes des lois asymptotiques à grand temps de l'enroulement autour d'un point dépendent des propriétés spectrales de basse énergied'une famille d'hamiltoniens contenant un potentiel vecteur de type Aharonov-Bohm.Le paragraphe 3 a pour l'objet l'étude de la loi de probabilité d'une fonctionnelle exponentielle du mouvement brownien qui intervient dans le cadnG de la diffusion unidimensionnelle aléatoire. Celle-ci apparaît notamment lorsque l'on s'intéresse à la distribution du flux de particules quitraverse un échantillon désordonné de taille finie, lorsque les particules diffusent classiquement, sous l'action d'une force aléatoire gelée distribuée comme un bruit blanc gaussien. Le spectre de relaxation de la distribution du flux par rapport à longueur de l'échantillon présente une branche continue et quelques états discrets, dont le nombre dépend de l'importance du désordre par rapport à la force moyenne.La fonctionnelle exponentielle étudiée intervient aussi dans l'étude du mouvement brownien libre sur le demi-plan de Poincaré, et s'inscrit plus largement dans le cadre des processus stochastiques multiplicatifs.

  5. Evidence Molded by Contact with Staff Culture and Patient Milieu: An Analysis of the Social Process of Knowledge Utilization in Nursing Homes

    ERIC Educational Resources Information Center

    Øye, Christine; Mekki, Tone Elin; Skaar, Randi; Dahl, Hellen; Forland, Oddvar; Jacobsen, Frode F.

    2015-01-01

    Knowledge utilization is politically "hot" because it informs decisions on improving the quality of care in nursing homes (NHs). The difficulties encountered in implementing evidence-based knowledge into practice may be explained by contextual factors. Contextual factors are crucial to understanding the process of knowledge utilization;…

  6. PolyICLC Exerts Pro- and Anti-HIV Effects on the DC-T Cell Milieu In Vitro and In Vivo

    PubMed Central

    Hallor, Magnus; Singer, Rachel; Tharinger, Hugo; Kenney, Jessica; Gettie, Agegnehu; Grasperge, Brooke; Blanchard, James; Salazar, Andres; Lifson, Jeffrey D.; Robbiani, Melissa; Derby, Nina

    2016-01-01

    Myeloid dendritic cells (mDCs) contribute to both HIV pathogenesis and elicitation of antiviral immunity. Understanding how mDC responses to stimuli shape HIV infection outcomes will inform HIV prevention and treatment strategies. The long double-stranded RNA (dsRNA) viral mimic, polyinosinic polycytidylic acid (polyIC, PIC) potently stimulates DCs to focus Th1 responses, triggers direct antiviral activity in vitro, and boosts anti-HIV responses in vivo. Stabilized polyICLC (PICLC) is being developed for vaccine adjuvant applications in humans, making it critical to understand how mDC sensing of PICLC influences HIV infection. Using the monocyte-derived DC (moDC) model, we sought to describe how PICLC (vs. other dsRNAs) impacts HIV infection within DCs and DC-T cell mixtures. We extended this work to in vivo macaque rectal transmission studies by administering PICLC with or before rectal SIVmac239 (SIVwt) or SIVmac239ΔNef (SIVΔNef) challenge. Like PIC, PICLC activated DCs and T cells, increased expression of α4β7 and CD169, and induced type I IFN responses in vitro. The type of dsRNA and timing of dsRNA exposure differentially impacted in vitro DC-driven HIV infection. Rectal PICLC treatment similarly induced DC and T cell activation and pro- and anti-HIV factors locally and systemically. Importantly, this did not enhance SIV transmission in vivo. Instead, SIV acquisition was marginally reduced after a single high dose challenge. Interestingly, in the PICLC-treated, SIVΔNef-infected animals, SIVΔNef viremia was higher, in line with the importance of DC and T cell activation in SIVΔNef replication. In the right combination anti-HIV strategy, PICLC has the potential to limit HIV infection and boost HIV immunity. PMID:27603520

  7. Modèle multi-échelle du transport de fluide dans un milieu poreux chargé avec échanges cationiques : application aux tissus osseux

    NASA Astrophysics Data System (ADS)

    Kaiser, Joanna; Lemaire, Thibault; Naili, Salah; Sansalone, Vittorio

    2009-11-01

    To better understand the bone diseases, many models of porous cortical bone have been developed to simulate its in vivo behaviour. Thus we proposed multiscale models including multiphysical phenomena governing the hydraulic response of bone. However, all these models neglected the possible ionic exchanges at the cellular level. Since such chemical reactions directly change the physico-chemical properties of the tissue, the interstitial flow is also modified. The aim of this study is so to include these ionic exchanges in the bone fluid transport description by deriving their consequences at the macroscale. To cite this article: J. Kaiser et al., C. R. Mecanique 337 (2009).

  8. Une méthode mécanique pour mesurer la pression de vapeur d'équilibre de l'eau dans un milieu complexe

    NASA Astrophysics Data System (ADS)

    Ouoba, Samuel; Cousin, Bruno; Cherblanc, Fabien; Bénet, Jean-Claude

    2010-02-01

    This Note presents a new method to measure the equilibrium vapour pressure of water in a complex medium. In this article a "complex medium" refers to a medium in which physico-chemical interactions alter the thermodynamical properties of the water, especially its activity and its equilibrium vapour pressure. This new method consists in placing a sample of the complex medium in a temperature-controlled chamber which volume can be incrementally increased by means of a piston. The equilibrium vapour pressure can be deduced from the variation of the equilibrium total pressure measured for each volume increment. The method has been validated on various saturated salt solutions and on a reference soil.

  9. Experiencias Educativas en el Medio Rural Colombiano. Serie Divulgacion No. 2. [Educational Experiences in the Rural Colombian Milieu. Circulation Series No. 2].

    ERIC Educational Resources Information Center

    Ministerio de Educacion Nacional, Bogota (Colombia). Centro Nacional de Documentacion e Informacion Pedagogica.

    In fulfillment of the Colombian National Government's educational policy aimed toward improving the rural population's level of living, two fundamental projects have been implemented. These projects have led to the creation of schools, the continuous extension of grades, and the creation of "Concentraciones de Desarrollo Rural." They seek to: (1)…

  10. L'education des adultes comme strategie d'implantation de l'education permanente en milieu universitaire: la lecon de la France (Adult Education as Strategy for Implementing Continuing Education in the University Setting: The Lesson of France).

    ERIC Educational Resources Information Center

    Ferland, Mario

    1981-01-01

    Lessons learned from the French experience in integrating continuing education into the universities include these: politically and ideologically, adult and continuing education are different and must be treated thus; autonomy is necessary; the university has no monopoly; and marginalization of adult education is a hazard of this approach. (MSE)

  11. Low and moderate doses of ionizing radiation up to 2 Gy modulate transmigration and chemotaxis of activated macrophages, provoke an anti-inflammatory cytokine milieu, but do not impact upon viability and phagocytic function.

    PubMed

    Wunderlich, R; Ernst, A; Rödel, F; Fietkau, R; Ott, O; Lauber, K; Frey, B; Gaipl, U S

    2015-01-01

    Benign painful and inflammatory diseases have been treated for decades with low/moderate doses of ionizing radiation (LD-X-irradiation). Tissue macrophages regulate initiation and resolution of inflammation by the secretion of cytokines and by acting as professional phagocytes. Having these pivotal functions, we were interested in how activated macrophages are modulated by LD-X-irradiation, also with regard to radiation protection issues and carcinogenesis. We set up an ex-vivo model in which lipopolysaccharide pre-activated peritoneal macrophages (pMΦ) of radiosensitive BALB/c mice, mimicking activated macrophages under inflammatory conditions, were exposed to X-irradiation from 0·01 Gy up to 2 Gy. Afterwards, the viability of the pMΦ, their transmigration and chemotaxis, the phagocytic behaviour, the secretion of inflammatory cytokines and underlying signalling pathways were determined. Exposure of pMΦ up to a single dose of 2 Gy did not influence their viability and phagocytic function, an important fact regarding radiation protection. However, significantly reduced migration, but increased chemotaxis of pMΦ after exposure to 0·1 or 0·5 Gy, was detected. Both might relate to the resolution of inflammation. Cytokine analyses revealed that, in particular, the moderate dose of 0·5 Gy applied in low-dose radiotherapy for inflammatory diseases results in an anti-inflammatory cytokine microenvironment of pMΦ, as the secretion of the proinflammatory cytokine interleukin (IL)-1β was reduced and that of the anti-inflammatory cytokine transforming growth factor (TGF)-β increased. Further, the reduced secretion of IL-1β correlated with reduced nuclear translocation of nuclear factor (NF)-κB p65, starting at exposure of pMΦ to 0·5 Gy of X-irradiation. We conclude that inflammation is modulated by LD-X-irradiation via changing the inflammatory phenotype of macrophages.

  12. Un Bain Culturel et Linguistique de Trois Mois en Milieu Francophone, Peut-Il effacer les Lacunes de l'Immersion (Can a Three-Month Interlinguistic Exchange in a Francophone Environment Overcome the Errors of Fossilization)?

    ERIC Educational Resources Information Center

    Lussier, Denise; Masse, Carole

    1995-01-01

    Reports on the speech difficulties of four French immersion anglophone students participating in a three-month interlinguistic exchange. Each student was interviewed three times, and the transcripts were analyzed for linguistic, sociolinguistic, and sociocultural errors in oral French and for performance evaluation by the students. (51 references)…

  13. Disentangling the microRNA regulatory milieu in multiple myeloma: integrative genomics analysis outlines mixed miRNA-TF circuits and pathway-derived networks modulated in t(4;14) patients.

    PubMed

    Calura, Enrica; Bisognin, Andrea; Manzoni, Martina; Todoerti, Katia; Taiana, Elisa; Sales, Gabriele; Morgan, Gareth J; Tonon, Giovanni; Amodio, Nicola; Tassone, Pierfrancesco; Neri, Antonino; Agnelli, Luca; Romualdi, Chiara; Bortoluzzi, Stefania

    2016-01-19

    The identification of overexpressed miRNAs in multiple myeloma (MM) has progressively added a further level of complexity to MM biology. miRNA and gene expression profiles of two large representative MM datasets, available from retrospective and prospective series and encompassing a total of 249 patients at diagnosis, were analyzed by means of in silico integrative genomics methods, based on MAGIA2 and Micrographite computational procedures. We first identified relevant miRNA/transcription factors/target gene regulation circuits in the disease and linked them to biological processes. Members of the miR-99b/let-7e/miR-125a cluster, or of its paralog, upregulated in t(4;14), were connected with the specific transcription factors PBX1 and CEBPA and several target genes. These results were validated in two additional independent plasma cell tumor datasets. Then, we reconstructed a non-redundant miRNA-gene regulatory network in MM, linking miRNAs, such as let-7g, miR-19a, mirR-20a, mir-21, miR-29 family, miR-34 family, miR-125b, miR-155, miR-221 to pathways associated with MM subtypes, in particular the ErbB, the Hippo, and the Acute myeloid leukemia associated pathways.

  14. Comprendre le processus d'adaptation des demarches d'enseignement en classe de sciences et technologies a l'ecole secondaire: Analyse des besoins percus par les personnes enseignantes en milieu defavorise

    NASA Astrophysics Data System (ADS)

    Houde, Sylvie

    Since the implementation of the latest reform in the education programs of Quebec, the adaptation of teaching has taken on an important place in the concerns of all actors in education. However, this adjustment towards the adoption of teaching practices that require more participation on the part of the pupil is not accomplished so easily, particularly in the field of science and technology (ST). In order to gain a better understanding of these processes of adaptation, it is opportune to question ourselves on the factors and dynamics of interest at stake, especially in disadvantaged environments. Such environments are faced with situations where other difficulties coexist: integration of pupils, lack of interest, problems in classroom management, multi-ethnicity, etc. As a result, such difficulties give rise to particular limitations, expressed in the form of needs, by pupils and teachers, likely to have a restrictive effect on the adaptation of teaching practices. Accordingly, our research focuses on the needs perceived by teachers in high school ST classrooms in disadvantaged school environments, since they present a privileged means to better understand the processes involved in the adaptation of practices. The adoption of an ecosystemic perspective, centered on these needs and their contribution towards the dynamics of decision-making, enabled us to better apprehend the complexity of these processes in ST classrooms. We were able to identify the needs perceived by teachers by following the methodology of conceptanalysis of needs, and by combining focus groups with the DRAP software. The results account for the large variety of needs to be considered in the equation of adaptation of teaching practices. These needs generally belong to the classroom system (microsystem). For pupils, they are mainly cognitive needs, but for teachers, they pertain to organization and structure. The influence of these needs on the adaptation processes depends on the interpretation by teachers of teaching situations, so much so that a same need can at times be assumed as negative pressure, generating obstacles, or at other times as a positive impulse, facilitating adaptation. Keywords: teaching practices; science and technology education; high school education; adaptation processes; needs assessment; disadvantaged environments.

  15. Novel Perspectives in Redox Biology and Pathophysiology of Failing Myocytes: Modulation of the Intramyocardial Redox Milieu for Therapeutic Interventions—A Review Article from the Working Group of Cardiac Cell Biology, Italian Society of Cardiology

    PubMed Central

    Arcaro, Alessia; Pirozzi, Flora; Angelini, Annalisa; Chimenti, Cristina; Crotti, Lia; Giordano, Carla; Mancardi, Daniele; Torella, Daniele; Tocchetti, Carlo G.

    2016-01-01

    The prevalence of heart failure (HF) is still increasing worldwide, with enormous human, social, and economic costs, in spite of huge efforts in understanding pathogenetic mechanisms and in developing effective therapies that have transformed this syndrome into a chronic disease. Myocardial redox imbalance is a hallmark of this syndrome, since excessive reactive oxygen and nitrogen species can behave as signaling molecules in the pathogenesis of hypertrophy and heart failure, leading to dysregulation of cellular calcium handling, of the contractile machinery, of myocardial energetics and metabolism, and of extracellular matrix deposition. Recently, following new interesting advances in understanding myocardial ROS and RNS signaling pathways, new promising therapeutical approaches with antioxidant properties are being developed, keeping in mind that scavenging ROS and RNS tout court is detrimental as well, since these molecules also play a role in physiological myocardial homeostasis. PMID:26881035

  16. Prévalence et facteurs de risque du surpoids et de l'obésité dans une population d'enfants scolarisés en milieu urbain à Sfax, Tunisie

    PubMed Central

    Regaieg, Sofien; Charfi, Nadia; Trabelsi, Lobna; Kamoun, Mahdi; Feki, Habib; Yaich, Sourour; Abid, Mohamed

    2014-01-01

    Introduction L'objectif de ce travail etait d’étudier la prévalence du surpoids et de l'obésité chez un groupe d'enfants d’âge scolaire, habitant la ville de Sfax en Tunisie, et identifier les facteurs favorisant la prise pondérale Méthodes Il s'agossait d'une enquête descriptive transversale était réalisée en 2011 sur un échantillon représentatif d’élèves recrutés dans 11 écoles primaires publiques. Des informations concernant les caractéristiques sociodémographiques, les habitudes alimentaires et le comportement sédentaire pour chaque élève ont été précisées au moyen d'un questionnaire Résultats Nous avons colligé 1529 élèves, âgés entre 9 et 12 ans et se répartissant en 787 garçons (51,14%) et 747 filles (48,86%). Selon les seuils de référence de l'IOTF, la fréquence de l'obésité était de 2,4% et celle du surpoids était de 6,3%. L'obésité était significativement associée à l'obésité parentale, un niveau socioéconomique élevé, la prise de plus de deux goûters par jour et à l'activité sédentaire. Conclusion L'identification des facteurs de risque du surpoids et de l'obésité infantile permettrait de dépister les enfants à risques afin de leur proposer des mesures de prévention adaptées. Ces mesures de prévention devraient inclure non seulement des approches individuelles, mais aussi l'environnement social et physique de l'enfant. PMID:25018807

  17. Croyances des Futurs Enseignants at L'Utilisation des Technologies de L'Information en Milieu Scholaire. (The Beliefs of Future Teachers About the Utilization of Information Technology in Schools.)

    ERIC Educational Resources Information Center

    IsaBell, Claire; Desjardin, Richard; Desjardins, Yvon

    2001-01-01

    Studies the attitudes of student teachers concerning integration of information technologies and communications (ITC) in school settings. Suggests that the motivation of these teachers is essential for ensuring the integration of microcomputers into the educational environment. Finds that, based on a research study, student teachers expressed…

  18. Assessment of physicochemical parameters and prevalence of virulent and multiple-antibiotic-resistant Escherichia coli in treated effluent of two wastewater treatment plants and receiving aquatic milieu in Durban, South Africa.

    PubMed

    Pillay, Leanne; Olaniran, Ademola O

    2016-05-01

    The poor operational status of some wastewater treatment plants often result in the discharge of inadequately treated effluent into receiving surface waters. This is of significant public health concern as there are many informal settlement dwellers (ISDs) that rely on these surface waters for their domestic use. This study investigated the treatment efficiency of two independent wastewater treatment plants (WWTPs) in Durban, South Africa and determined the impact of treated effluent discharge on the physicochemical and microbial quality of the receiving water bodies over a 6-month period. Presumptive Escherichia coli isolates were identified using biochemical tests and detection of the mdh gene via PCR. Six major virulence genes namely eae, hly, fliC, stx1, stx2, and rfbE were also detected via PCR while antibiotic resistance profiles of the isolates were determined using Kirby-Bauer disc diffusion assay. The physicochemical parameters of the wastewater samples ranged variously between 9 and 313.33 mg/L, 1.52 and 76.43 NTUs, and 6.30 and 7.87 for COD, turbidity, and pH respectively, while the E. coli counts ranged between 0 and 31.2 × 10(3) CFU/ml. Of the 200 selected E. coli isolates, the hly gene was found in 28 %, fliC in 20 %, stx2 in 17 %, eae in 14 %, with stx1 and rfbE in only 4 % of the isolates. Notable resistance was observed toward trimethoprim (97 %), tetracycline (56 %), and ampicillin (52.5 %). These results further highlight the poor operational status of these WWTPs and outline the need for improved water quality monitoring and enforcement of stringent guidelines.

  19. Disentangling the microRNA regulatory milieu in multiple myeloma: integrative genomics analysis outlines mixed miRNA-TF circuits and pathway-derived networks modulated in t(4;14) patients

    PubMed Central

    Manzoni, Martina; Todoerti, Katia; Taiana, Elisa; Sales, Gabriele; Morgan, Gareth J.; Tonon, Giovanni; Amodio, Nicola; Tassone, Pierfrancesco; Neri, Antonino; Agnelli, Luca; Romualdi, Chiara; Bortoluzzi, Stefania

    2016-01-01

    The identification of overexpressed miRNAs in multiple myeloma (MM) has progressively added a further level of complexity to MM biology. miRNA and gene expression profiles of two large representative MM datasets, available from retrospective and prospective series and encompassing a total of 249 patients at diagnosis, were analyzed by means of in silico integrative genomics methods, based on MAGIA2 and Micrographite computational procedures. We first identified relevant miRNA/transcription factors/target gene regulation circuits in the disease and linked them to biological processes. Members of the miR-99b/let-7e/miR-125a cluster, or of its paralog, upregulated in t(4;14), were connected with the specific transcription factors PBX1 and CEBPA and several target genes. These results were validated in two additional independent plasma cell tumor datasets. Then, we reconstructed a non-redundant miRNA-gene regulatory network in MM, linking miRNAs, such as let-7g, miR-19a, mirR-20a, mir-21, miR-29 family, miR-34 family, miR-125b, miR-155, miR-221 to pathways associated with MM subtypes, in particular the ErbB, the Hippo, and the Acute myeloid leukemia associated pathways. PMID:26496024

  20. Assessment of physicochemical parameters and prevalence of virulent and multiple-antibiotic-resistant Escherichia coli in treated effluent of two wastewater treatment plants and receiving aquatic milieu in Durban, South Africa.

    PubMed

    Pillay, Leanne; Olaniran, Ademola O

    2016-05-01

    The poor operational status of some wastewater treatment plants often result in the discharge of inadequately treated effluent into receiving surface waters. This is of significant public health concern as there are many informal settlement dwellers (ISDs) that rely on these surface waters for their domestic use. This study investigated the treatment efficiency of two independent wastewater treatment plants (WWTPs) in Durban, South Africa and determined the impact of treated effluent discharge on the physicochemical and microbial quality of the receiving water bodies over a 6-month period. Presumptive Escherichia coli isolates were identified using biochemical tests and detection of the mdh gene via PCR. Six major virulence genes namely eae, hly, fliC, stx1, stx2, and rfbE were also detected via PCR while antibiotic resistance profiles of the isolates were determined using Kirby-Bauer disc diffusion assay. The physicochemical parameters of the wastewater samples ranged variously between 9 and 313.33 mg/L, 1.52 and 76.43 NTUs, and 6.30 and 7.87 for COD, turbidity, and pH respectively, while the E. coli counts ranged between 0 and 31.2 × 10(3) CFU/ml. Of the 200 selected E. coli isolates, the hly gene was found in 28 %, fliC in 20 %, stx2 in 17 %, eae in 14 %, with stx1 and rfbE in only 4 % of the isolates. Notable resistance was observed toward trimethoprim (97 %), tetracycline (56 %), and ampicillin (52.5 %). These results further highlight the poor operational status of these WWTPs and outline the need for improved water quality monitoring and enforcement of stringent guidelines. PMID:27037695

  1. Apoptosis, DAP-Kinase1 Expression and the Influences of Cytokine Milieu and Mesenchymal Stromal Cells on Ex Vivo Expansion of Umbilical Cord Blood-Derived Hematopoietic Stem Cells.

    PubMed

    Amirizadeh, Naser; Oodi, Arezoo; Mehrasa, Roya; Nikougoftar, Mahin

    2016-03-01

    Expansion of umbilical cord blood-derived CD34(+) cells can potentially provide them in numbers sufficient for clinical applications in adult humans. In this study apoptosis rate of expanded cells, mRNA expression and promoter methylation status of DAPK1 were evaluated during cord blood hematopoietic stem cell (CB-HSC) ex vivo expansion using cytokines and a co-culture system with mesenchymal stromal cells (MSCs). Ex vivo cultures of CB-HSCs were performed in three culture conditions for 14 days: cytokines with MSCs feeder layer, cytokines without MSCs feeder layer and co-culture with MSCs feeder layer without cytokine. Total number of cells, CD34(+) cells and colony forming unit assay were performed during expansion. Flow cytometric analysis by propidium iodide was performed to detection of apoptosis rate in expanded cells. Methylation status of the DAPK1 gene promoter was analyzed using methylation specific PCR, and DAPK1 mRNA expression was evaluated by real time-PCR. Maximum CB-CD34(+) cells expansion was observed in day 10 of expansion. The highest apoptosis rate was observed in cytokine culture without feeder layer that showed significant difference with co-culture condition. The data showed that ex vivo expansion of CD34(+) cells in all three culture conditions after 10 days resulted in, significant increased expression of DAPK1, also a significant difference between co-culture without cytokine and two other cytokine culture was observed (p < 0.01). DAPK1gene promoter of expanded CD34(+) cells at days 5, 10 and 14 of culture remained in unmethylated form similar to fresh CD34(+) cells. Expression of DAPK1 in hematopoietic cells was increased during 10 days expansion of CD34(+) cells. Also no methylation of DAPK1 promoter was observed; otherwise it would be capable of initiating some leukemic cell progression or disruption in hematopoietic regeneration.

  2. Étude expérimentale du dépôt de particules colloïdales en milieu poreux : Influence de l'hydrodynamique et de la salinité

    NASA Astrophysics Data System (ADS)

    Djehiche, Abdelkader; Canseco, Vladimir; Omari, Aziz; Bertin, Henri

    2009-09-01

    This study deals with colloid transport in porous media which applications are found in subsurface water, petroleum engineering or civil engineering. An experimental study of colloidal polystyrene Latex particles deposition in a consolidated porous medium is presented. The influence of ionic strength of the colloid suspension and the flow rate on particle deposition is investigated. We see first that beyond a critical salt concentration, the total collector efficiency increases with the ionic strength. Moreover, such collector efficiency decreases as the flow rate increases according to theory. In other respects, using a γ ray attenuation technique allows us to measure local porosity fluctuation due to particles deposition. By this way deposition kinetics may be followed locally and precisely. Nevertheless when considering the thickness of the adsorbed layer over large scales, obtained results using the γ rays attenuation technique are found in good agreement with those obtained by means of an usual technique especially at latest stages of adsorption process. To cite this article: A. Djehiche et al., C. R. Mecanique 337 (2009).

  3. Disentangling the microRNA regulatory milieu in multiple myeloma: integrative genomics analysis outlines mixed miRNA-TF circuits and pathway-derived networks modulated in t(4;14) patients.

    PubMed

    Calura, Enrica; Bisognin, Andrea; Manzoni, Martina; Todoerti, Katia; Taiana, Elisa; Sales, Gabriele; Morgan, Gareth J; Tonon, Giovanni; Amodio, Nicola; Tassone, Pierfrancesco; Neri, Antonino; Agnelli, Luca; Romualdi, Chiara; Bortoluzzi, Stefania

    2016-01-19

    The identification of overexpressed miRNAs in multiple myeloma (MM) has progressively added a further level of complexity to MM biology. miRNA and gene expression profiles of two large representative MM datasets, available from retrospective and prospective series and encompassing a total of 249 patients at diagnosis, were analyzed by means of in silico integrative genomics methods, based on MAGIA2 and Micrographite computational procedures. We first identified relevant miRNA/transcription factors/target gene regulation circuits in the disease and linked them to biological processes. Members of the miR-99b/let-7e/miR-125a cluster, or of its paralog, upregulated in t(4;14), were connected with the specific transcription factors PBX1 and CEBPA and several target genes. These results were validated in two additional independent plasma cell tumor datasets. Then, we reconstructed a non-redundant miRNA-gene regulatory network in MM, linking miRNAs, such as let-7g, miR-19a, mirR-20a, mir-21, miR-29 family, miR-34 family, miR-125b, miR-155, miR-221 to pathways associated with MM subtypes, in particular the ErbB, the Hippo, and the Acute myeloid leukemia associated pathways. PMID:26496024

  4. Endometrial ablation in the management of abnormal uterine bleeding.

    PubMed

    Laberge, Philippe; Leyland, Nicholas; Murji, Ally; Fortin, Claude; Martyn, Paul; Vilos, George; Leyland, Nicholas; Wolfman, Wendy; Allaire, Catherine; Awadalla, Alaa; Dunn, Sheila; Heywood, Mark; Lemyre, Madeleine; Marcoux, Violaine; Potestio, Frank; Rittenberg, David; Singh, Sukhbir; Yeung, Grace

    2015-04-01

    Contexte : Les saignements utérins anormaux (SUA) sont directement à l’origine d’un fardeau de santé considérable que doivent porter les femmes, leur famille et la société en général. Jusqu’à 30 % des femmes chercheront à obtenir l’aide d’un médecin pour contrer ce problème au cours de leurs années de fertilité. Objectif : Fournir des lignes directrices factuelles à jour quant aux techniques et aux technologies utilisées aux fins de l’ablation de l’endomètre (AE), soit une intervention à effraction minimale permettant la prise en charge des SUA d’origine bénigne. Méthodes : Les membres du comité sur la directive clinique ont été sélectionnés en fonction de leurs spécialisations respectives en vue de représenter une gamme d’expériences pratiques et universitaires : le milieu de pratique au Canada, le type de pratique, la sous-spécialité et les antécédents généraux en gynécologie ont donc été pris en considération. Le comité a analysé les données pertinentes issues de la littérature médicale anglophone (y compris les lignes directrices publiées), en plus d’évaluer les issues chirurgicales et les issues qu’ont connues les patientes à la suite de l’utilisation de diverses techniques d’AE. Les recommandations ont été formulées par consensus. Données : La littérature publiée a été récupérée par l’intermédiaire de recherches menées dans MEDLINE et The Cochrane Library en 2013 et en 2014 au moyen d’un vocabulaire contrôlé et de mots clés appropriés (p. ex. « endometrial ablation », « hysteroscopy », « menorrhagia », « heavy menstrual bleeding », « AUB », « hysterectomy »). Les résultats ont été restreints aux analyses systématiques, aux études observationnelles et aux essais comparatifs randomisés / essais cliniques comparatifs publiés en anglais entre janvier 2000 et novembre 2014. Les recherches ont été mises à jour de façon r

  5. Évaluation des propriétés énergétiques et microphysiques d'une source de convection artificielle à partir d' une étude de combustion organisée de fuel-oil en milieu naturel

    NASA Astrophysics Data System (ADS)

    Dinh, Pham Van; Benech, B.; Diamant, W.

    To evaluate the potential environmental impacts of waste heat released by future dry cooling towers, an oil burning system which emits sensible heat at a rate of the order of 1000 MW into the atmosphere has been built up at the Centre de Recherches Atmosphériques. The project involved development of an oil burner device and experiments to quantify the amounts of heat and other matters released from oil combustion, such as gas and aerosol, that are not present in the case of cooling towers but may interact with heat and cause complications. The burner produces a flame of 3-5 m in height and 0.5-1.5 m in diameter. Fuel is consumed at a rate of 3.5-16.5 ℓ min -1 at a pressure of 30-60 bars to develop a thermal output of 3-11 MW. The thermal power is distributed into three parts: sensible heat (82%), radiative energy (7-13%) and forced convection energy ( ~ 6 %); the two latter energy forms also heat the ambient air and so increase the real sensible heat output which eventually reaches 90 % of the thermal power. When the plume rises to some tens of meters, the combustion gas density is not very different from the air density and the additional water vapor does not exceed 5 % of the ambient water vapor. Smoke aerosol produced at the rate of 2-6gkg -1 of fuel-oil exhibits a maximum concentration of 10 7 particles cm -3 with a mean diameter of 0.5μm. The aerosol consists essentially of hydrophobic carbon (97%), while other elements, that may form hygroscopic or ice nuclei are present only in trace concentrations. The gaseous sulfur content may be higher but the SO 2 oxidation rate is very slow and then the cloud condensation nuclei amounts injected by the plume are neglegible in comparison with the natural nuclei. Thus the thermal impact on the atmosphere of the fuel oil combustion is essentially due to its thermodynamic characteristics, and our 105-burner system (Météotron) should correctly simulate in full scale a dry cooling tower. The smoke particles are quite useful as they make the plume visible and are used as passive tracers of the thermal disturbance.

  6. Workplace Learning: The Role of Canadian Colleges and Institutes in Meeting Canada's Professional, Technical and Trade Skills Challenges = L'apprentissage en milieu de travail: Le role des colleges et instituts canadiens face aux defis canadiens en matiere des competences professionnels et techniques.

    ERIC Educational Resources Information Center

    Malcolmson, Lorna, Ed.

    2002-01-01

    This issue examines selected topics in vocational education in Canadian community colleges. It focuses on the central themes of community college and industry partnerships, vocational education assessment, and vocational and workplace education pedagogical models. Articles include: (1) "Industry and Colleges: Key Partners in Meeting Canada's…

  7. Effet de la substitution du cuivre par du lithium sur les proprietes de l'oxyde spinelle lithium(x)cuivre(y-x)cobalt(3-y)oxygen(4) etudie pour l'electrocatalyse de la reaction de degagement de l'oxygene en milieu alcalin

    NASA Astrophysics Data System (ADS)

    Fatih, Khalid

    L'electrolyse de l'eau demeure la seule technologie industrielle de generation de l'hydrogene et de l'oxygene tres purs sans rejet de CO2 dans l'atmosphere, ce qui le rend tres attrayant par rapport a la combustion de carburants fossiles qui provoque presentement de serieux problemes environnementaux. Dans le but d'ameliorer le rendement de ce procede, nous avons developpe de nouveaux materiaux d'anode peu couteux, a base de l'oxyde mixte CuyCo3-yO 4, qui possedent une cinetique rapide pour la reaction de degagement de l'oxygene (RDO). Cette reaction suscite un interet particulier en raison de la surtension d'activation relativement elevee a l'anode qui cause la principale perte de rendement du procede. Une etude systematique a ete effectuee sur la substitution du Cu par du Li (0 a 40%), afin d'elucider les proprietes electrocatalytiques des oxydes LixCuy-xCo3-yO4. Ces oxydes, prepares sous forme de poudres par decomposition thermique des nitrates precurseurs entre 300 et 500°C, ont montre (DRX et FTIR) une structure spinelle inverse non-stcechiometrique avec une diminution du volume de la maille cristalline. La surface specifique par BET est d'environ 6 m2 g-1. Le pcn, obtenu par titrage acido-basique, a indique une diminution de la force du lien M-OH avec le taux du Li dans l'oxyde. Les analyses par XPS, realisees sur des films d'oxyde prepares par nebulisation reactive sur un substrat lisse de nickel, revelent un enrichissement de la surface en Cu a partir de 30% Li, et la presence des cations de surface Co2+, Co3+, Cu +, Cu2+ et Cu3+. La concentration de ce dernier montre un maximum a 10 et 20% Li. Suite a la substitution du Cu par du Li, la compensation de la charge serait assuree principalement par la formation d'especes Cu3+ pour les oxydes contenant jusqu'a 20% Li, et par la formation d'especes Co3+ aux taux de substitution superieurs. Les micrographies MEB montrent une morphologie hemispherique des particules d'oxyde reparties uniformement sur le substrat de nickel avec une tendance a l'agglomeration lorsque le taux de Li est accru. Les micrographies AFM revelent une micro-porosite de ces particules d'oxyde. Les films minces deposes sur un substrat de verre ont montre une conductivite tres interessante de l'ordre de 103O-1 cm-1 pour LixCuy-x Co3-yO4 comparee a 2,8 O-1 cm-1 pour Co3O4. La spectroscopie d'impedance a permis de distinguer les processus de la surface interne des films d'oxydes de ceux de l'interface electrode/electrolyte. Les courbes Mott-Schottky (1/C2 en fonction du potentiel) montrent que les films d'oxyde se comportent comme des semi-conducteurs de type p tres dopes (degeneres). Le potentiel de bandes plates et la densite des porteurs de charge majoritaires des oxydes LixCuy-xCo3-yO4 sont de l'ordre de 0,48 a 0,52 V et 1019 a 10 20 cm-3 respectivement. Pour Co 3O4 ces parametres sont de 0,47 V et ≈10 18 cm-3. (Abstract shortened by UMI.)

  8. Modélisation du transport réactif en milieu poreux : schéma itératif associé à une combinaison d'éléments finis discontinus et mixtes-hybridesModelling reactive transport in porous media: iterative scheme and combination of discontinuous and mixed-hybrid finite elements

    NASA Astrophysics Data System (ADS)

    Carrayrou, Jérôme; Mosé, Robert; Behra, Philippe

    2003-03-01

    The sequential iterative approach (SIA) scheme is the most efficient method for modelling reactive transport in porous media with the operator-splitting approach. A combination of finite discontinuous and finite mixed-hybrid elements is a powerful method for solving solute transport in porous media, but the use of this method for SIA scheme induces numerical difficulties. In this paper, a new method is developed to solve reactive transport by using both the SIA scheme and a combination of finite discontinuous and finite mixed elements. The proposed method is tested by modelling a column experiment. To cite this article: J. Carrayrou et al., C. R. Mecanique 331 (2003).

  9. Policy Conversation on Workplace/Workforce Literacy (Toronto, Ontario, Canada, January 22-24, 1995): A Report = Dialogue de Politique sur l'Alphabetisation en Milieu de Travail/de la Main-d'Oeuvre (Toronto, Ontario, Canada, 22-24 Janvier, 1995): Un Document de Synthese.

    ERIC Educational Resources Information Center

    National Literacy Secretariat, Ottawa (Ontario).

    This document is a compilation of a variety of documents that were prepared to summarize and document the Policy Conversation on Workplace and Work Force Literacy that was held in Canada to give concerned individuals an opportunity to share their hopes, concerns, dreams, and visions about key issues in workplace literacy. The following documents…

  10. Hyperglycemia and anthocyanin inhibit quercetin metabolism in HepG2 cells

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A high glucose (Glu) milieu promotes generation of reactive oxygen species, which may not only cause cellular damage, but also modulate phase II enzymes that are responsible for the metabolism of flavonoids. Thus, we examined the effect of a high Glu milieu on quercetin (Q) metabolism in HepG2 cells...

  11. Kinderland in the Fatherland: Growing Children in Imperial Berlin

    ERIC Educational Resources Information Center

    Brian, Amanda

    2009-01-01

    This dissertation explores the milieu in which children of Imperial Berlin were raised. When contemporaries in the rapidly expanding capital of the Second German Empire (1871-1918) looked at children, this milieu darkened. The city, they argued, threatened children's growing bodies, and such institutions as the home, the clinic, and the school…

  12. Atrial fibrillation: relation between clinical risk factors and transoesophageal echocardiographic risk factors for thromboembolism

    PubMed Central

    Illien, S; Maroto-Järvinen, S; von der Recke, G; Hammerstingl, C; Schmidt, H; Kuntz-Hehner, S; Lüderitz, B; Omran, H

    2003-01-01

    Objective: To correlate clinical risk factors for thromboembolism with transoesophageal echocardiography (TOE) markers of a thrombogenic milieu. Design: Clinical risk factors for thromboembolism and TOE markers of a thrombogenic milieu were assessed in consecutive patients with non-rheumatic atrial fibrillation. The following TOE parameters were assessed: presence of spontaneous echo contrast, thrombi, and left atrial appendage blood flow velocities. A history of hypertension, diabetes mellitus, or thromboembolic events, patient age > 65 years, and chronic heart failure were considered to be clinical risk factors for thromboembolism. Setting: Tertiary cardiac care centre. Patients: 301 consecutive patients with non-rheumatic atrial fibrillation scheduled for TOE. Results: 255 patients presented with clinical risk factors. 158 patients had reduced left atrial blood flow velocities, dense spontaneous echo contrast, or both. Logistic regression analysis showed that a reduced left ventricular ejection fraction and age > 65 years were the only independent predictors of a thrombogenic milieu (both p < 0.0001). The probability of having a thrombogenic milieu increased with the number of clinical risk factors present (p < 0.0001). 17.4% of the patients without clinical risk factors had a thrombogenic milieu whereas 41.2% of the patients presenting one or more clinical risk factors had none. Conclusion: There is a close relation between clinical risk factors and TOE markers of a thrombogenic milieu. In addition, TOE examination allows for the identification of patients with a thrombogenic milieu without clinical risk factors. PMID:12527668

  13. The valves, baffles and sphincters of the respiratory system.

    PubMed

    Baggot, M G

    1992-02-01

    'Starting with the integument we see many organs are contractile sacs or multiples thereof which tubes or bags constitute the major part of the entire body' (1). The lungs are a collection of these universal contractile chambers connected in chains and bunches. Such containers typically have muscular walls which stretch and contract to fill and empty also valves or sphincters to regulate the flow between neighbouring chambers. The heart, stomach and uterus are familiar examples. In some systems (e.g. the digestive, renal and respiratory tracts) traffic is also between the milieu exterior and the milieu interior through the organ's wall which is part of the integument. These movements from organ to organ or milieu to milieu involve pressure variations generated by the concerted actions of the mural and valvular muscles. A muscle usually has a doppel-gänger so they are arranged in reciprocating pairs, supinators with pronators, flexors with extensors, chamber walls with sphincters etc.

  14. Biomarkers of Lung Injury

    EPA Science Inventory

    Unlike the hepatic, cardiovascular, nervous, or excretory organ systems, where there .ls a strong contribution of host factors or extracellular biochemical milieu in causing organ damage, the causes of lung injuries and subsequent diseases are primarily from direct environmental ...

  15. Educational Institutions or Extended Families? The Reconstruction of Gender in Women's Colleges in the Late Nineteenth and Early Twentieth Centuries.

    ERIC Educational Resources Information Center

    Edwards, Elizabeth

    1990-01-01

    Examines the world of women's colleges in Victorian Britain, presenting much biographical information and period detail, with an aim toward illuminating the emotional and sexual dynamics of this milieu. (DM)

  16. Saying Good-bye in Residential Treatment.

    ERIC Educational Resources Information Center

    Bale, Tom

    1979-01-01

    Presents the case history of a 13-year-old asthmatic boy in residential treatment in order to illustrate how experiences in the milieu can become a vehicle for a child to gain better control over separation anxiety. (CM)

  17. Impact of mycobacterial culture among HIV-infected adults with presumed TB in Uganda: a prospective cohort study.

    PubMed

    Semitala, F C; Chaisson, L H; den Boon, S; Walter, N; Cattamanchi, A; Awor, M; Katende, J; Huang, L; Joloba, M; Albert, H; Kamya, M R; Davis, J L

    2015-06-21

    Contexte : La mise en œuvre de nouvelles stratégies de diagnostic de la tuberculose (TB) dans les contextes de ressources limitées constitue un défi. Nous avons mesuré l'impact des cultures mycobactériennes en milieu solide et liquide sur les pratiques de traitement des patients ayant une évaluation de la TB à Kampala, Ouganda.Méthodes : Nous avons enrôlé des patients adultes consécutifs à frottis négatif, positifs pour le virus de l'immunodéficience humaine avec toux de ⩾2 semaines, de septembre 2009 à avril 2010. Les techniciens de laboratoire ont réalisé des cultures mycobactériennes en milieu solide et liquide. Nous avons comparé les décisions de traitement empirique aux cultures en milieu solide et liquide en termes de rendement diagnostique et de délai d'obtention des résultats et nous avons évalué l'impact sur la gestion des patients.Résultats : Des 200 patients enrôlés, 26 (13%) avaient une TB confirmée par culture, 22 (85%) par culture en milieu solide seule, 2 (8%) par culture en milieu liquide seul et 2 (8%) par culture à la fois en milieu solide et liquide. Trente-quatre patients ont reçu un traitement de TB empirique, mais seulement 10 (29%) ont eu une TB à culture positive. Le délai médian d'obtention d'un résultat de culture positive en milieu solide a été de 92 jours (IQR 69–148). Le délai médian d'obtention d'un résultat de culture positive en milieu liquide a été de 106 jours (IQR 66–157). Aucun patient n'a commencé un traitement à la suite d'un résultat de culture positive en milieu liquide.Conclusion : L'introduction de la culture mycobactérienne n'a pas influencé les soins aux patients bénéficiant d'une évaluation de TB à Kampala, Ouganda. Il est nécessaire d'être attentif aux facteurs contextuels entourant la mise en œuvre afin d'assurer une introduction effective de nouvelles stratégies de tests dans les pays à faible revenu.

  18. Les infections à Pseudomonas aeruginosa au service des maladies infectieuses du CHU YO, Burkina Faso: à propos deux cas

    PubMed Central

    Mamoudou, Savadogo; Lassina, Dao; Fla, Koueta

    2015-01-01

    Nous rapportons deux cas d'infection à Pseudomonas aeruginosa: un cas de méningite et un cas d'infection urinaire. Les auteurs rappellent qu’à côté des étiologies classiques des méningites et des infections urinaires, des germes résistants comme Pseudomonas aeruginosa peuvent être responsables d'infections à localisation méningées et urinaires et dont il faut connaître pour une bonne prise en charge. Le traitement de ces infections requiert un antibiogramme au regard de la grande capacité de résistance de Pseudomonas aeruginosa en milieu hospitalier. La limitation des gestes invasifs et l'application rigoureuse des mesures de prévention des infections en milieu hospitalier contribueront à lutter efficacement contre ces infections en milieu de soins. PMID:26491521

  19. Effective psychiatric day treatment: historical lessons.

    PubMed

    Rosie, J S; Azim, H F; Piper, W E; Joyce, A S

    1995-10-01

    This paper describes a successful day treatment program that provides four months of intensive psychodynamic group-oriented milieu treatment for patients with long-standing personality disorders, who commonly experience recurrent major depression, dysthymia, and excessive anxiety. The authors outline three factors that have contributed to the success of the program--optimal treatment-patientmatching, judicious use of authority in milieu therapy, and careful attention to maintaining close working relationships with referral sources. They provide an overview of the historical evolution of day treatment programs from earlier day hospital model to show day programs' neglect of these factors may have led to treatment failures. Such failures may have spurred recent suggestions that psychiatric day treatment programs should be replaced entirely by assertive community treatment. The authors argue that such a move could amount to abdication of psychiatry's responsibility to provide intensive milieu treatment that can be effectively offered only on a day treatment basis. PMID:8829782

  20. What's New in Treating Inpatients With Personality Disorders?: Dialectical Behavior Therapy and Old-Fashioned, Good Communication.

    PubMed

    Ritter, Sarah; Platt, Lois M

    2016-01-01

    Psychiatric unit inpatients often have serious mental illnesses with comorbid personality disorders. Mental illnesses usually respond favorably to medication and psychotherapy, but personality disorders do not. Two personality disorders are commonly seen on inpatient units: borderline and antisocial. These personality disorders may destabilize the milieu with disruptive behaviors and present a challenge to nurses. Difficult patient behaviors and therapeutic responses by nurses are examined. Dialectical behavior therapy techniques and good communication skills may be used by nurses to (a) interact therapeutically with patients with personality disorders and (b) protect other patients and the milieu.

  1. Symposium: "Crash": Rhetorically Wrecking Discourses of Race, Tolerance, and White Privilege

    ERIC Educational Resources Information Center

    Nunley, Vorris L.

    2007-01-01

    From within the milieu of race and identity fatigue emerges "Crash." Winner of three Academy Awards, including Best Picture, "Crash" addresses how the fluidity of identity is pooled, ebbed, blocked, directed, dammed up. How identity and subjectivity are dammed up and mediated through the force of the anxieties, fears, and frustrations of people…

  2. Comparing Cyberbullying and School Bullying among School Students: Prevalence, Gender, and Grade Level Differences

    ERIC Educational Resources Information Center

    Lapidot-Lefler, Noam; Dolev-Cohen, Michal

    2015-01-01

    Recent technological developments have added cyberspace as part of adolescents' social milieu. Bullying, which is prevalent in adolescents' social environment, also takes place in cyberspace, although it is believed to have a more potent and harmful effect. A study of cyberbullying and FtF bullying could elucidate critical implications for…

  3. Anorexia Nervosa.

    ERIC Educational Resources Information Center

    Westerlage, Patricia A.

    The author traces the case histories of five anorexic female patients treated in the therapeutic milieu in a psychiatric inpatient unit. The history of anorexia nervosa is reviewed, incidence of the disorder is cited, and common characteristics are described. Case histories are presented in terms of events precipitating the weight loss, behavior…

  4. The Multilingual Classroom: New Rhetorical Frontiers in L2 Writing?

    ERIC Educational Resources Information Center

    Magistro, Elena

    2007-01-01

    This paper presents some considerations on teaching L2 rhetorical conventions in university-level multilingual classrooms. It is claimed that if L2 students need to acquire versatile writing skills in L2 to be given a voice in the discourse milieu of the receiving society, they should also have the right to preserve their L1 cultural perspective.…

  5. L'acquisition d'une language seconde: Quelques developpements theoriques recents (Second Language Acquisition: Some Recent Theoretical Developments).

    ERIC Educational Resources Information Center

    Py, Bernard, Ed.

    1994-01-01

    This collection of articles on second language learning includes: "Action, langage et discours. Les fondements d'une psychologie du langage" ("Action, Language, and Discourse. Foundations of a Psychology of Language") (Jean-Paul Bronckart); "Contextes socio-culturels et appropriation des languages secondes: l'apprentissage en milieu social et la…

  6. Characterization and mucosal responses of interleukin 17 family ligand and receptor genes in channel catfish Ictalurus punctatus

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Interleukin (IL) 17 family cytokines are important mediators of mucosal immune responses, tightly regulated by signals from the complex milieu of pathogenic and commensal microbes, epithelial cells and innate and adaptive leukocytes found at tissue barriers. In mammals, IL17 ligand expression has be...

  7. The Experience of Initial Management Training in ELT

    ERIC Educational Resources Information Center

    Rimmer, Wayne

    2016-01-01

    Management training in ELT organizations is often inadequate. New managers are in severe need of training, especially for tasks which are non-pedagogical, yet they operate in a milieu where there are few opportunities for support compared with colleagues in mainstream education. The purpose of this case study, a rare evidence-based contribution to…

  8. Moderate Pluralism: Beyond a Reasonable Liberalism to Recognition of Cultural Expertise

    ERIC Educational Resources Information Center

    Fraser-Burgess, Sheron

    2010-01-01

    The growing diversity of school populations in the present education milieu raises issues of treating difference along multiple lines of the social, political and economic well being of children. Difference is here defined as politically significant group identities to which the author refers as cultures or identity groups. Political liberal…

  9. A Physiologist's View of Homeostasis

    ERIC Educational Resources Information Center

    Modell, Harold; Cliff, William; Michael, Joel; McFarland, Jenny; Wenderoth, Mary Pat; Wright, Ann

    2015-01-01

    Homeostasis is a core concept necessary for understanding the many regulatory mechanisms in physiology. Claude Bernard originally proposed the concept of the constancy of the "milieu interieur," but his discussion was rather abstract. Walter Cannon introduced the term "homeostasis" and expanded Bernard's notion of…

  10. Towards an Understanding of Mindful Practices with Children and Adolescents in Residential Treatment

    ERIC Educational Resources Information Center

    Abrams, Heidi

    2007-01-01

    The author discusses mindful practices with children and adolescents in the residential treatment milieu. The article presents the current literature as well as three case studies informing theoretical and practical viewpoints of these practices as interventions and philosophies towards healing and growth.

  11. Design Milieux for Learning Environments in African Contexts

    ERIC Educational Resources Information Center

    Duveskog, Marcus; Sutinen, Erkki; Cronje, Johannes

    2014-01-01

    During the years 2002 to 2009, five African settings were used as foundation for designing different learning environments. While the content and target group for each learning environment varied, all of their design settings, or milieux, shared one implicit expectation: the milieu should facilitate the production of a change-making learning…

  12. Sex and Occupational Socialization among Prison Guards: A Longitudinal Study.

    ERIC Educational Resources Information Center

    Crouch, Ben M.; Alpert, Geoffrey P.

    1982-01-01

    Reports changes in attitudes of male and female prison guards over the first six months on the job. Found male guards became more, and female guards became less, punitive and aggressive. Results appear to derive from differences in the work milieu of male and female guards. (Author/JAC)

  13. Outdoor Education Gives Fewer Demands for Action Regulation and an Increased Variability of Affordances

    ERIC Educational Resources Information Center

    Fiskum, Tove Anita; Jacobsen, Karl

    2013-01-01

    In children's lives there are a lot of instigators for actions in every milieu and situation. When children grow older, the cortical activity starts to regulate the action instigation from the limbic system. The school system makes demands of action regulation for children. In outdoor education the many instigators for actions are not under the…

  14. Seeking Resilience and Sustainability: Outdoor Education in Singapore

    ERIC Educational Resources Information Center

    Martin, Peter; Ho, Susanna

    2009-01-01

    Outdoor education is not a universal value. Rather, outdoor education's contributions need to be grounded in time, place and culture. In this paper we describe the historical and cultural milieu that has enabled the emergence of outdoor education in Singapore and report on exploratory survey research into Singaporean teachers' conceptions of…

  15. From Command to Constructivism: Canadian Secondary School Physical Education Curriculum and "Teaching Games for Understanding"

    ERIC Educational Resources Information Center

    Singleton, Ellen

    2009-01-01

    Canadian physical educators have fought long and hard to be recognized as legitimate contributors to school curricula. In claiming alliances with discourses of medicine and morality, science and psychology, proponents of physical education have sought to be recognized and validated within the educational milieu. These claims have fundamentally…

  16. Language Contact, Language Loyalty, and Language Prejudice on the Mexican Border.

    ERIC Educational Resources Information Center

    Hidalgo, Margarita

    1986-01-01

    Documents attitudes toward English, Spanish, and Spanish-English code-switching in Juarez, Mexico. This paper refutes the notion that there are two orientations--integrative and instrumental--toward English as a second language, but it supports assumptions regarding the relationship between attitudes and use and the impact of local milieu on…

  17. Peddling Poverty for Profit: Elements of Oppression in Ruby Payne's Framework

    ERIC Educational Resources Information Center

    Gorski, Paul C.

    2008-01-01

    Ruby Payne, CEO of aha! Process, Inc., and author of "A Framework for Understanding Poverty" (2005), has become one of the most influential figures in the U.S. public education milieu. Payne's framework, built largely upon understanding the "culture" of poverty, instructs educators on the values and mindsets poor students carry into the classroom…

  18. School Readiness of Children with Language Impairment: Predicting Literacy Skills from Pre-Literacy and Social-Behavioural Dimensions

    ERIC Educational Resources Information Center

    Pentimonti, Jill M.; Murphy, Kimberly A.; Justice, Laura M.; Logan, Jessica A. R.; Kaderavek, Joan N.

    2016-01-01

    Background: School readiness generally captures the notion that children do best when they arrive at formal schooling with a certain threshold of skill that will help them thrive in the classroom's academic and social milieu. Aims: To examine the dimensionality of the construct of school readiness among children with language impairment (LI), as…

  19. The Contributions of Rebecca Caudill and Dorothy Hoobler to Appalachian Literature for Young Adults.

    ERIC Educational Resources Information Center

    Warner, Mary

    Rebecca Caudill, born in 1899 in Poor Fork (now Cumberland), Kentucky, lived until 1985 and devoted a major portion of her life to writing young adult and children's literature. With one exception, Caudill's books, numbering 17, are all set in Appalachia, each one portraying something of the life, the milieu, and the richness of the mountain…

  20. Cultural and Social Capital and Talent Development: A Study of a High-Ability Aboriginal Student in a Remote Community

    ERIC Educational Resources Information Center

    Kostenko, Karen; Merrotsy, Peter

    2009-01-01

    During the course of a school year, a study was conducted on the cultural context, the social milieu and the personal characteristics of a high ability Aboriginal student in a remote community in Canada. Using the lenses of cultural capital, social capital and human capital, the study explores the development of the student's talent through his…

  1. Self-Efficacy for Refusal Mediated by Outcome Expectancies in the Prediction of Alcohol-Dependence amongst Young Adults.

    ERIC Educational Resources Information Center

    Williams, Robert J.; Connor, Jason P.; Ricciardelli, Lina A.

    1998-01-01

    Examines the relative importance of outcome expectancies and self-efficacy in the production of alcohol dependence and alcohol consumption in a sample of young adult drinkers drawn from a milieu previously reported as supportive of risky drinking. Results suggest that heavy drinking women are particularly at risk of developing drinking-related…

  2. L'enseignement au niveau avance: Problemes et essais (Instruction on the Advanced Level: Problems and Experiments).

    ERIC Educational Resources Information Center

    Racle, G.

    The determination of Objectives conditions the choice of materials, methods, and evaluation of results in all stages of foreign language learning. The first level is a necessary foundation, but by itself is insufficient for the study of literature or for communication purposes in a new linguistic milieu. The fundamental notion of language styles…

  3. Ethnolinguistic Vitality, Self-Confidence and Second Language Proficiency: An Investigation.

    ERIC Educational Resources Information Center

    Labrie, Normand; Clement, Richard

    1986-01-01

    Ninth-grade Francophone students (N=95) living in a bicultural milieu responded to tests including scales of ethnolinguistic vitality, attitudes, motivation, self-confidence, and second language competence and usage. Analyses indicated that contact with Anglophones and self-confidence with English as a second language were related to motivation,…

  4. Beyond an Initial Campus Heritage Survey: Creating an Infrastructure for Renewal

    ERIC Educational Resources Information Center

    Neuman, David J.

    2011-01-01

    Given their value to the student experience, institutional identity, alumni loyalty, and economic welfare, historic preservation efforts must unite with institutional sustainability efforts and other high priorities to develop an approach for mutual success. Further, it is important to recognize the limits in the current milieu of economic…

  5. Tracing Family, Teaching Race: Critical Race Pedagogy in the Millennial Sociology Classroom

    ERIC Educational Resources Information Center

    Mueller, Jennifer C.

    2013-01-01

    The "millennial" historical moment presents fresh dilemmas for race-critical instructors. In addition to being well-versed in colorblind racial discourse, millennial students are socialized in a pop-cultural milieu that implies a more integrated, racially egalitarian world than exists in reality and includes claims that U.S. society is now…

  6. The Impact of Cultural Religious Values upon Pre-Service Teachers' Perceptions of Their Role as Educators in Catholic Religious Schools

    ERIC Educational Resources Information Center

    Gellel, Adrian-Mario; Buchanan, Michael T.

    2011-01-01

    The particular history, politics, social milieu and size of the islands of Malta contributed to the formation of specific cultural values and identity. Central to this identity is a unique language and a very strong Catholic community. These factors remain integral (but not exclusive) aspects of the Maltese national identity. This identity has…

  7. Growing People: A Model That Works. Welcome to Success. The School Program Narrative of the Yellowstone Boys and Girls Ranch School.

    ERIC Educational Resources Information Center

    Yellowstone Boys and Girls Ranch School, Billings, MT.

    The booklet describes the philosophy and operation of the Yellowstone Boys and Girls Ranch School Program, an integrated public school residential treatment mainstream educational model located within an accredited residential psychiatric facility in Montana. The therapeutic milieu is designed to redirect children's self-perception. Descriptive…

  8. Seeking Restorative Experiences: Elementary School Teachers' Choices for Places that Enable Coping with Stress

    ERIC Educational Resources Information Center

    Gulwadi, Gowri Betrabet

    2006-01-01

    Teacher stress and coping research and restorative environments research were converged in this study to explore how elementary school teachers in Chicago seek out everyday places in their milieu to implement restorative coping strategies. Seventy-one survey responses revealed that teachers' spontaneous place choices are related to sources of…

  9. Commodification of Ghana's Volta River: An Example of Ellul's Autonomy of Technique

    ERIC Educational Resources Information Center

    Agbemabiese, Lawrence; Byrne, John

    2005-01-01

    Jacques Ellul argued that modernity's nearly exclusive reliance on science and technology to design society would threaten human freedom. Of particular concern for Ellul was the prospect of the technical milieu overwhelming culture. The commodification of the Volta River in order to modernize Ghana illustrates the Ellulian dilemma of the autonomy…

  10. Youth Victimization: School Climate or Deviant Lifestyles?

    ERIC Educational Resources Information Center

    Zaykowski, Heather; Gunter, Whitney

    2012-01-01

    Despite much focus on school violence, there has been little research that explores the relationship between offending and victimization in various school climates. School climate theory suggests that the school's social system, culture, milieu, and ecological structure affect student outcomes including academic performance, delinquency, and more…

  11. The Differential Effect of Three Naturalistic Language Interventions on Language Use in Children with Autism

    ERIC Educational Resources Information Center

    Ingersoll, Brooke

    2011-01-01

    Naturalistic interventions show promise for improving language in children with autism. Specific interventions differ in direct elicitation of child language and indirect language stimulation, and thus may produce different language outcomes. This study compared the effects of responsive interaction, milieu teaching, and a combined intervention on…

  12. Allergic Contact Dermatitis to Eye Drops

    PubMed Central

    Bhat, Yasmeen Jabeen; Zeerak, Sumaya; Hassan, Iffat

    2015-01-01

    Allergic contact dermatitis (ACD) occurs due to a milieu of allergens and involves different anatomical sites, including eyelids, and periorbital areas. Topically applied ophthalmic drugs are a potential cause of ACD of the periorbital region. Here we describe the report of a patient who developed ACD to eye drop preparations. PMID:26677304

  13. Treating Drug Addiction in the Minority Communities: The Decade Ahead.

    ERIC Educational Resources Information Center

    Drew, Joseph S.

    While scholars are not in accord on the basic causes of contemporary drug abuse among minority Americans, most do agree that the social milieu of the drug abuser is fundamental. It has been urged that racism, poverty, police brutality and harrassment, the economics of addiction, the hopelessness of ghetto life, peer pressure, educational…

  14. Mobile Applications and Decolonization: Cautionary Notes about the Curriculum of Code

    ERIC Educational Resources Information Center

    Smith, Bryan

    2016-01-01

    The current generation of students live and learn within a pedagogical milieu saturated by digital technologies. Curriculum scholars have not ignored this, theorizing and critiquing the ways that technology both affords and limits opportunities for students. Notably absent from this conversation, however, is a consideration of how the technologies…

  15. The Authority of Truth: Religion and the John Peter Zenger Case.

    ERIC Educational Resources Information Center

    Nord, David Paul

    1985-01-01

    Argues that an appreciation of the religious milieu of the Zenger case can help to explain the nature of the defense, the meaning of the jury's verdict, and the ambiguous legacy of the trial for freedom of expression in the United States. (FL)

  16. The Authority of Truth: Religion and the John Peter Zenger Case.

    ERIC Educational Resources Information Center

    Nord, David Paul

    An appreciation of the religious milieu of the John Peter Zenger libel case of 1735 can help explain the nature of the Zenger defense as prepared by Alexander Hamilton, the meaning of the jury's verdict, and the ambiguous legacy of the trial for freedom of expression in the United States. In essence, the case was a disputation on "truth" and on…

  17. Perceptions of Teacher Collegial Work Groups at the Department Level in Southern California

    ERIC Educational Resources Information Center

    Guerrero, Frank C.

    2012-01-01

    Since the inception of a "Nation at Risk" (1983) and the gradual growth of the school reform movement over the following several decades, the social and political milieu that exist today under No Child Left Behind (NCLB) can be best described as an era in which public education is fending itself from extinction and takeover, often from…

  18. A Study of On-the-Job Training. Technical Paper No. 13.

    ERIC Educational Resources Information Center

    Scribner, Sylvia; Sachs, Patricia

    A case study of on-the-job training in a factory stockroom took a close look at the working milieu, the way experienced people did their jobs within it, and the means used to induct (train) newcomers into work activities. Stockroom work and stockroom training were considered to represent two different activity systems; the interplay of these two…

  19. Sociocultural Factors in Client-Counsellor Self-Disclosure in Nigeria, Africa

    ERIC Educational Resources Information Center

    Oluwatosin, S. A.

    2014-01-01

    This paper reviews various factors that interplay in the counselling sessions within the cultural milieu of African society, especially Nigeria and particularly within the context of school-based counselling provision. These factors, which were found to be both sociological and cultural, hamper effective client self-disclosure during counselling…

  20. Computers: from ethos and ethics to mythos and religion. Notes on the new frontier between computers and philosophy

    SciTech Connect

    Mitcham, C.

    1986-01-01

    This essay surveys recent studies concerning the social, cultural, ethical and religious dimensions of computers. The argument is that computers have certain cultural influences which call for ethical analysis. Further suggestions are that American culture is itself reflected in new ways in the high-technology computer milieu, and that ethical issues entail religious ones which are being largely ignored. 28 references.

  1. Integrating Multiple Identities: Narrative in the Formation and Maintenance of the Self in International School Students

    ERIC Educational Resources Information Center

    Sears, Coreen

    2011-01-01

    This article reports on an investigation into the formation and maintenance of identity in globally mobile children and young people in the setting of an international school. The findings suggest that students at the school sustain composite identities that encompass their multiple experiences. The school itself offers a milieu which recognizes…

  2. Participative Decision-Making About Work: An Overdue Look at Variables Which Mediate its Effects

    ERIC Educational Resources Information Center

    Singer, Jack N.

    1974-01-01

    Besides the question of the maximal effectiveness of various degrees and varieties of participation, predicting the success of participative decision making (PDM) approaches also involves an understanding of sources of variance (individual employees' characteristics, the cultural milieu, and the job context and level) for planning and instituting…

  3. Techniques for Teaching Standard English Composition to English as a Second Dialect Students.

    ERIC Educational Resources Information Center

    Edwards, Thomas O.

    English as a second dialect (ESD) students are those who have developed linguistic patterns from their parents and other members of their cultural milieu. Since the ESD students seldom find themselves in a setting that demands the use of standard English, they come to higher education with a well developed linguistic pattern that is alien to…

  4. Grand Designs! Analysing the Conceptual Tensions Associated with New Physical Education and Health and Well-Being Curriculum

    ERIC Educational Resources Information Center

    Thorburn, Malcolm; Horrell, Andrew

    2014-01-01

    The positioning of physical education in the school curriculum continues to reflect external discourses circulating in political and social milieu. As increasing austerity measures influence and restrict educational priorities, we consider that there is an urgent need for physical educationalists to articulate a rationale for an educational…

  5. Passport to the Front of the Bus: The Impact of Fisk University's International Program on Segregation in Nashville, Tennessee.

    ERIC Educational Resources Information Center

    Gasman, Marybeth

    In the 1950's, Charles S. Johnson, the first black president of Fisk University (Tennessee), greatly expanded the institution's international program, attracting many foreign students to the school and creating a milieu that gave American blacks the benefits of integration. This paper examines how the presence of outsiders and outside influences…

  6. Teachers' Professional Development for ICT Integration: Towards a Reciprocal Relationship between Research and Practice

    ERIC Educational Resources Information Center

    Albion, Peter R.; Tondeur, Jo; Forkosh-Baruch, Alona; Peeraer, Jef

    2015-01-01

    Teachers in the 21st century are facing new challenges as a result of the expanding possibilities of ICT integration in every aspect of the school milieu. Studies have shown the potential of teacher professional development (TPD) that is tailored to local conditions as well as global components and takes advantage of mutual support among teachers,…

  7. Dynamic Assessment of Graphic Symbol Combinations by Children with Autism.

    ERIC Educational Resources Information Center

    Nigam, Ravi

    2001-01-01

    This article offers teaching strategies in the dynamic assessment of the potential of students with autism to acquire and use multiple graphic symbol combinations for communicative purposes. Examples are given of the matrix strategy and milieu language teaching strategies. It also describes the Individualized Communication-Care Protocol, which…

  8. Identity Formation of American Indian Adolescents: Local, National, and Global Considerations

    ERIC Educational Resources Information Center

    Markstrom, Carol A.

    2011-01-01

    A conceptual model is presented that approaches identity formation of American Indian adolescents according to 3 levels of social contextual influence--local, national, and global--relative to types of identity, dynamics of identity, and sources of influence. Ethnic identity of American Indians is embedded within the local cultural milieu and…

  9. Trust Development in Outdoor Leadership

    ERIC Educational Resources Information Center

    Shooter, Wynn; Paisley, Karen; Sibthorp, Jim

    2010-01-01

    Establishing trusting relationships between leaders and participants is one way that outdoor leaders can create an emotionally safe and productive milieu that supports the attainment of desirable outcomes. Multidisciplinary literature offers considerable insight into leader trust development and the outcomes that are linked to trust in a leader.…

  10. A RESEARCH DEMONSTRATION TO ASSESS THE EFFECTIVENESS OF A SPECIAL LIVING UNIT WITHIN A UNIVERSITY DORMITORY SETTING FOR THE REHABILITATION OF STUDENTS DISABLED BY EMOTIONAL DISTURBANCE.

    ERIC Educational Resources Information Center

    SINNETT, E. ROBERT

    USE OF A RESIDENCE HALL AS A THERAPEUTIC MILIEU FOR DISTURBED COLLEGE STUDENTS IS DESCRIBED IN THIS REPORT OF A RESEARCH AND DEMONSTRATION STUDY. THE EXPERIMENTAL GROUP CONSISTED OF TEN DISTURBED STUDENTS, AND A CONTROL GROUP WAS COMPOSED OF 10 VOLUNTEER STUDENTS. ALL STUDENTS PARTICIPATED IN THE REGULAR RESIDENCE HALL PROGRAMS (ORGANIZATIONAL…

  11. Left-Wing Tragedy or Comic Opera?: A New Look at the Demise of "The Masses".

    ERIC Educational Resources Information Center

    Heinze, Kirk

    Although the suppression in 1917 of "The Masses," an influential Socialist magazine, has been depicted as an American tragedy, such a narrow interpretation ignores the bizarre, confused, often comic developments and episodes that attended the magazine's end. A reexamination of the demise of "The Masses" has been made to show the milieu in which…

  12. ICT Training Courses for Teacher Professional Development in Jordan

    ERIC Educational Resources Information Center

    Abuhmaid, Atef

    2011-01-01

    Information and Communication Technology (ICT) is increasingly having pervasive role and presence in the educational milieu as it continues to shape all aspects of our lives. Numerous reform projects have been in place aiming to infuse ICT across education systems. Teachers are widely believed to be the key agents of any educational change.…

  13. Evaluation of a Screening Test for Female College Athletes with Eating Disorders and Disordered Eating.

    ERIC Educational Resources Information Center

    Nagel, Deborah L.; Black, David R.; Leverenz, Larry J.; Coster, Daniel C.

    2000-01-01

    Developed the Athletic Milieu Direct Questionnaire (AMDQ) to detect female college athletes with eating disorders/disordered eating (ED/DE). Athletes from various sports completed the AMDQ, two other tests, and a structured diagnostic interview to determine which test screened most effectively. The AMDQ identified ED/DE more accurately than the…

  14. On the Nature of the Semiotic Structure of the Didactic Action: The Joint Action Theory in Didactics within a Comparative Approach

    ERIC Educational Resources Information Center

    Sensevy, Gérard; Gruson, Brigitte; Forest, Dominique

    2015-01-01

    In this paper, we first sketch the joint action theory paradigm from a general viewpoint in sciences of culture. Then we specify this generic description by focusing on the joint action theory in didactics (JATD). We elaborate on three currently developed elements of the theory: the reticence-expression dialectics; the contract-milieu dialectics,…

  15. Succession planning for RNs: implementing a nurse management internship.

    PubMed

    Wendler, M Cecilia; Olson-Sitki, Kristi; Prater, Marsha

    2009-01-01

    The nursing shortage affects all levels, including the pivotal role of nurse managers, who may find themselves functioning in a complex, stressful work environment. In this increasingly difficult milieu, succession planning for nurse manager turnover is imperative. The authors describe an evidence-based, theoretically driven nurse management internship that allows staff nurses to explore the nurse manager role.

  16. A Rationale for Creating African-American Immersion Schools.

    ERIC Educational Resources Information Center

    Holt, Kenneth C.

    1991-01-01

    The traditional U.S. classroom's milieu has distorted and refused to recognize the language and cultural richness of African-American students. Milwaukee's two immersion schools, Victor Berger Elementary School and Parkman Middle School, place the African-American students and their culture at the center of the educational process. Results have…

  17. Towards a Sociology of Linguistics.

    ERIC Educational Resources Information Center

    Marchand, James W.

    One of the more interesting facets of the philosophy of science today is the stress placed on the sociology of knowledge. People have slowly come to realize that knowledge is to a great extent conditioned by the ambience, the social milieu in which it exists. In the present paper, an attempt is made to draw a miniature socio-profile of the field…

  18. Impact of dietary fibers on nutrient management and detoxification organs: gut, liver, and kidneys

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Increased dietary fiber (DF) intake elicits a wide range of physiological effects, not just locally in the gut, but systemically. Dietary fibers can greatly alter the gut milieu by impacting the gut microbiome, which in turn influences the gut barrier, gastrointestinal immune and endocrine response...

  19. Leading Collective Capacity in Culturally Diverse Schools

    ERIC Educational Resources Information Center

    Walker, Allan; Riordan, Geoff

    2010-01-01

    We discuss the ways leaders may nurture collective relationships within culturally diverse staff bodies. We organise our discussion around five key, interrelated issues. These are how leaders position themselves within the school's cultural milieu; how they structure work for collective capacity; understanding collective work; giving expression to…

  20. Linking Ruth to Her Past

    PubMed Central

    Justin, Renate G.

    2004-01-01

    A family physician shares the story of her 3-decade-long relationship with a patient and the strong ties that they formed. Although she was taught to keep emotionally distant from her patients in order to maintain the best therapeutic milieu, this relationship enriched the author’s experience as a physician and ministered to her patient’s needs. PMID:15506591

  1. Brazilian Teacher Education Revealed through the Life Stories of Great Educators.

    ERIC Educational Resources Information Center

    Abrahao, Maria Helena Menna Barreto

    2002-01-01

    Discusses issues of teaching and teacher education found in the biographies of eminent Brazilian teacher educators which present their personal stories, their social milieu, and influences by Brazilian socioeconomic and cultural contexts. Each biography highlights specific educational characteristics of, influences upon, and theoretical frameworks…

  2. Rethinking Critical Thinking and Its Role in Art Museum Education

    ERIC Educational Resources Information Center

    Hubard, Olga

    2011-01-01

    Meaningful interactions with works of art are often absent from education. Across the country, art museums are intent on changing this situation. But to incorporate art viewing into an educational milieu that does not value art, art museum educators are constantly forced to justify the educational value of their programs. One common argument to…

  3. Development of pre-implantation porcine embryos cultured within a three-dimensional alginate hydrogel system either conjugated with Arg-Gly-Asp (RGD) peptide or supplemented with secreted phosphoprotein 1 (SPP1)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Many uterine specific factors have been shown to be increased within the uterine milieu as the porcine embryo initiates elongation. Secreted phosphoprotein 1 (SPP1) is increased during this time and contains an Arg-Gly-Asp (RGD) peptide sequence that has been shown to bind to cell surface integrins ...

  4. Teaching and Learning Competent Historical Documentary Making: Lessons from National History Day Winners

    ERIC Educational Resources Information Center

    Fehn, Bruce R.; Schul, James E.

    2011-01-01

    Today's students grow up in a technological milieu of hand-held computers with high storage capacities, internet access, and the ability to shoot high definition photographs and video. As such, they are empowered to construct representations of the past virtually "on the run." In this article, the authors investigated the historical "and"…

  5. Studying Intertextuality, Discourse and Narratives to Conceptualize and Contextualize Online Learning Environments

    ERIC Educational Resources Information Center

    Voithofer, Rick

    2006-01-01

    To demonstrate how qualitative methods can be used to guide the planning of online learning within the cultural and intertextual milieu of the Internet, this project gives the data, methods and the results of the contextualization and conceptualization of an online learning environment. The learning environment addressed and invited people with…

  6. An Invitation to Postmodern Social Cartography.

    ERIC Educational Resources Information Center

    Paulston, Rolland G.; Liebman, Martin

    1994-01-01

    Structures of multiple education and knowledge systems can be recreated in maps, in a social cartography where the space of the social map reflects effects of social changes in real space. Such maps allow social research to escape from modernism's positivist restraints, improve comparative educators' understanding of the social milieu, and open…

  7. Invitation to a Postmodern Reflection on Critical Social Cartography.

    ERIC Educational Resources Information Center

    Paulston, Rolland G.; Liebman, Martin

    This document demonstrates how social cartography can be used in social research to include individuals and cultural clusters who want their own narratives included in the social discourse. Social cartography is defined as the creation of maps addressing questions of location in the social milieu. Visual images, depicting on the two dimensional…

  8. An Invitation to Postmodern Social Cartography.

    ERIC Educational Resources Information Center

    Paulston, Rolland G.; Liebman, Martin

    This essay demonstrates how social cartography--the writing and reading of maps addressing questions of location in the social milieu--may enhance social research and move it forward in its struggles to distance itself from the positivistic restraints of modernism. Social cartography suggests an opening of dialogue among diverse social players,…

  9. Project SISS: Social Skills Program. Draft

    ERIC Educational Resources Information Center

    Sargent, Laurence R.

    The curriculum, developed by Project SISS (Systematic Instruction of Social Skills) in Des Moines, Iowa, contains about 100 lessons for use with mildly mentally handicapped children at primary, intermediate, junior high, and senior high levels. The social skill lessons were developed along an age related, expanding milieu concept and include the…

  10. Elementary School Classroom Teacher Delivered Physical Education: Costs, Benefits and Barriers

    ERIC Educational Resources Information Center

    Sherman, Clay P.; Tran, Cynthia; Alves, Yara

    2010-01-01

    Given academic priorities and budgetary constraints in the current elementary school milieu, the classroom teacher will likely remain a primary physical education provider. Understanding classroom teachers' perspectives related to costs, benefits, and barriers to teaching physical education is essential to understanding physical education…

  11. The Purposes Outdoor Education Does, Could and Should Serve in Singapore

    ERIC Educational Resources Information Center

    Ho, Susanna

    2014-01-01

    This paper discusses the purposes that outdoor education does, could and should serve in Singapore. Gert Biesta's conceptualisation of three functions of education is adapted to frame deliberations on the purposes of outdoor education in Singapore's socio-political and educational milieu. The author suggests that outdoor education in…

  12. Fostering Activities of Daily Living by Intact Nursing Home Residents

    ERIC Educational Resources Information Center

    Blair, Charles E.; Glaister, Judy; Brown, Alston; Phillips, Carolyn

    2007-01-01

    We assessed effectiveness of four education programs in providing nursing assistants with ability to produce a therapeutic milieu supportive of intact residents' activities of daily living, positive self-esteem and mood: (1) a combination of Orem's Systems of Nursing Care and Skinner's Applied Behavioral Analysis, (2) Applied Behavioral Analysis,…

  13. Augmenting Caregiver Responsiveness: An Intervention Proposal for Youngsters with Autism in Brazil

    ERIC Educational Resources Information Center

    Nunes, Débora R. P.; Araújo, Eliana R.; Walter, Elizabeth; Soares, Rute; Mendonça, Camila

    2016-01-01

    Language disorders that affect children with autism spectrum disorder can bring significant damage to their overall development. Research shows that the best treatment practices for this population are those that start early, have active parental collaboration and are held in natural milieu. In Brazil, early intervention programs are typically…

  14. Tensions in Defining Quality Pre-School Education: The Singapore Context

    ERIC Educational Resources Information Center

    Lim-Ratnam, Christina

    2013-01-01

    Over the past decade, the government in Singapore has been introducing many initiatives in the early childhood sector to raise the quality of pre-school education. Educational reforms made without consideration of the perspectives and concerns of the participants in the socio-cultural milieu would only lead to superficial implementation. This…

  15. Piaget Versus Materialism: A Concordance of the Discordance.

    ERIC Educational Resources Information Center

    Burger, Henry G.

    The purpose of this paper is to disconfirm Piaget's theory of an invariant sequence of intellectual maturation for all youths in all cultures. The author's view is that the kinds and sequences of human development vary greatly, depending on the cultural milieu. The author derives 36 propositions from Piaget's theory, dismisses 5 of them as…

  16. US Higher Education in a Budgetary Vortex--1992-2007: Tracing the Positioning of Academe in the Context of Growing Inequality

    ERIC Educational Resources Information Center

    de Oliver, Miguel; Briscoe, Felecia M.

    2011-01-01

    Through comparative statistical data of public investment trends in higher education, the institution of higher education in the US is contemporarily contextualized within the growing milieu of disparity. Specifically, this study focuses on the period from 1992 to 2007 to see if a mitigation of the growing economic disparity projected per the…

  17. Urbanism from the Perspective of Ecological Psychologists

    ERIC Educational Resources Information Center

    Gump, Paul V.; Adelgerg, Bettina

    1978-01-01

    A perception of ecological psychology on urbanism is presented, with emphasis on the following premises: (1) Urban milieu consists of complexes of behavior settings; and (2) Size of a city should be understood in relationship to the number and variety of its settings, rather than in terms of population size. (Author/MA)

  18. Empowering Grandparents Raising Grandchildren: A Training Manual for Group Leaders. Springer Series on Life Styles and Issues in Aging.

    ERIC Educational Resources Information Center

    Cox, Carole B.

    Noting that grandparents in the parenting role are often overwhelmed by the problems of their children, grandchildren, and the social milieu in which they live, this manual presents a 14-session workshop series designed to empower grandparents who are raising their grandchildren alone. Designed to complement "To Grandmother's House We Go and…

  19. Sailing through Stormy Seas: An Israeli Kindergarten Teacher Confronts Holocaust Remembrance Day

    ERIC Educational Resources Information Center

    Brody, David

    2009-01-01

    The young child's exposure to disaster and trauma through the media or in the social milieu poses a challenge for the early childhood educator who is faced with responding and educating in a developmentally appropriate manner. In the case of public commemoration of a national disaster, the classroom implications are seemingly unavoidable. This…

  20. Client Views of TESOL Service: Expectations and Perceptions.

    ERIC Educational Resources Information Center

    Walker, John

    2001-01-01

    Used focus groups to explore TESOL (teaching of English to speakers of other languages) client expectations and perceptions of the service they received in New Zealand English language schools. Findings confirmed the key role of the teacher and the importance of the school's milieu and home stay, quality of client feedback systems, servicescape,…

  1. Cultural Models in Communication with Infants: Lessons from Kikaikelaki, Cameroon and Muenster, Germany

    ERIC Educational Resources Information Center

    Demuth, Carolin; Keller, Heidi; Yovsi, Relindis D.

    2012-01-01

    Child rearing is a universal task, yet there are differing solutions according to the dynamics of socio-cultural milieu in which children are raised. Cultural models of what is considered good or bad parenting become explicit in everyday routine practices. Focusing on early mother-infant interactions in this article we examine the discursive…

  2. Crossing the Boundaries.

    ERIC Educational Resources Information Center

    Levy-Reiner, Sherry, Ed.

    1986-01-01

    Interdisciplinary programs at nine colleges and universities are described. An introductory essay, "Reflections from an Interdisciplinary Milieu," by Donald N. Levine discusses the benefits of an interdisciplinary emphasis for undergraduate education. The following programs are featured: Bowdoin College's environmental studies program; Brown…

  3. Work-Sport Competition: The Role of Agricultural Contests in New Zealand

    ERIC Educational Resources Information Center

    Tipples, Rupert; Wilson, Jude

    2007-01-01

    Contests that take place within the rural milieu have tended to be ignored. Yet a wide range of contests are associated with the rural/agricultural lifestyle. In New Zealand, for example, there are contests which judge specialised agricultural skills such as shearing, fencing, wood chopping or pruning, as well as those which assess assorted skills…

  4. Organization Model of a Constructivist Learning Community: A Teilhardian Metaphor for Educators.

    ERIC Educational Resources Information Center

    White, Stephen R.

    2002-01-01

    Argues for learning communities as a fruitful milieu for cognitive development and knowledge construction. Provides a metaphor of a constructivist learning community organization grounded on French scientist and philosopher Pierre Teilhard de Chardin's theory of evolution. Asserts that Teilhardian thought is useful for conceptualizing a…

  5. Hormonal profile impact on female sexual function in young women

    NASA Astrophysics Data System (ADS)

    Stoian, Dana; Craciunescu, Mihalea; Craina, Marius; Pater, Liana; Pater, Flavius

    2014-12-01

    Female sexual function is dependent, in physiological milieu upon hormonal impulses: estradiol, testosterone, cortisol, progesterone, prolactin and TSH. Out study tries to appreciate the impact of testosterone, estradiol and prolactin, the major hormones involved in the sexual response, on the normal sexual function. This parameter is approximated by the value of the total FSFI score, a validated international structured interview.

  6. Practical Curriculum Inquiry: Students' Voices of Their EFL Curriculum and Instruction

    ERIC Educational Resources Information Center

    Hongboontri, Chantarath

    2014-01-01

    This mixed-methods study borrowed Schwabian notions of practical curriculum inquiry (1969, 1971, 1973, 1983) to investigate students' perceptions of their English as a foreign language (EFL) curriculum and instruction in light of their interactions with the four commonplaces; i.e., teachers, learners, subject matter, and milieu. Data were…

  7. Trude Weiss-Rosmarin: Rebel with a Cause.

    ERIC Educational Resources Information Center

    Reed, Barbara Straus

    1995-01-01

    Profiles Trude Weiss-Rosmarin, a German-Jewish immigrant to America who, in 1935, published an independent magazine of Jewish ideas. Notes that the periodical focused on Jewish survival in an assimilationist milieu and the role of Jewish women. States that Weiss-Rosmarin lectured frequently, attracted important readers, and contributed…

  8. Harmonizing the Educational Globe. World Polity, Cultural Features, and the Challenges to Educational Research

    ERIC Educational Resources Information Center

    Trohler, Daniel

    2010-01-01

    The general thesis of this paper is that the motives of the currently dominant global educational governance are rooted in a specific cultural milieu in the time of the Cold War, more precisely in the late 1950s, heading to a harmonious world. The more specific thesis is that a series of failures in the achievement of this harmonized globe led to…

  9. Life, Health and Life Satisfaction in Middletown, U.S.A.

    ERIC Educational Resources Information Center

    Morris, David C.

    The area of subjective well-being has been and continues to be of interest to gerontologists. This study examined life satisfaction of older adults within the milieu of a classic, sociological community setting, Middletown, U.S.A. Data were gathered from 400 telephone interviews with respondents who were 60 years or older in the Muncie/Delaware…

  10. Social Relationships and Perceived Well-Being of Older Adults in Contemporary Middletown.

    ERIC Educational Resources Information Center

    Morris, David C.

    The general objective of this study was to examine life satisfaction within the milieu of a classic, sociological, community setting: Middletown, U.S.A. Subjects (N=400) were persons, 60 years of age and older, over one-half of whom were married and most of whom had at least one living child. A significant majority of these older Middletowners…

  11. Hybridized Discourse: Social Openness and Functions of English Media in Post-Mao China.

    ERIC Educational Resources Information Center

    Zhongshi, Guo; Yu, Huang

    2002-01-01

    Investigates the real and potential functions of English media in the milieu of social openness in post-Mao China. The unique position of China's English media reflects key characteristics of a "hybridized discourse" and a style of reporting that seems both keen to control and eager to please. (Author/VWL)

  12. "The Last of the Mohicans" Reconsidered.

    ERIC Educational Resources Information Center

    Merchant, Peter

    1993-01-01

    Identifies in the novel, "The Last of the Mohicans," some of the artistic strategies by which James Fenimore Cooper converted the tale into the novel. Considers why the novel continues to provoke cultural interest in today's milieu. Overviews the historical reception of the work. (HB)

  13. A Native American Voice in Multicultural Psychology: Finding Healing in an Interpersonal Tapestry

    ERIC Educational Resources Information Center

    Robbins, Rockey R.

    2012-01-01

    The tribal-cultural milieu in which the author was raised incited awareness that Native American people live in a great tapestry of life where everything and everyone is interconnected. It is an awareness that cannot be taught through lectures or books. It is an awareness of connectedness that Native American people had in early childhood but was…

  14. The Use and Performance of Hymnody, Spirituals, and Gospels in the Black Church.

    ERIC Educational Resources Information Center

    Maultsby, Portia K.

    1983-01-01

    Explores use and performance of music in the Black church through examination of (1) the events that led to the conversion of Blacks to Christianity; (2) the formation of independent Black religious groups; and (3) the social and cultural milieu that fostered the development of a unique Black religious music. (Author/ML)

  15. Underwater communication. FOA-STU project 4: Maritime technology

    NASA Astrophysics Data System (ADS)

    Goetherstroem, L.; Kleman, B.; Lindquist, R.; Pentelius, T.

    1980-04-01

    Technological forecasts for underwater communication by acoustical, optical, or radio techniques are summarized. Results on transmission by the various means were evaluated under different hypotheses for the aqueous milieu. Technological possibilities, the need for underwater communications in assorted applications, and a practical assessment of the potential for realization are considered. Conclusions lead to a proposal for a series of development projects.

  16. Common Core, Commonplaces, and Community in Teaching Reading

    ERIC Educational Resources Information Center

    Roskos, Kathleen; Neuman, Susan B.

    2013-01-01

    Joseph Schwab, a curriculum theorist, described four commonplaces, or universals, of teaching: content, students, milieu and teachers. This article considers how the Reading Standards of the ELA-CCSS are shaping these commonplaces in the teaching of reading. The organization of the Reading Standards, for example, focuses on two broad grade bands,…

  17. Disenchantment and the Liberal Arts

    ERIC Educational Resources Information Center

    Lathangue, Robin

    2012-01-01

    This paper is an enquiry into the unpredictability of the liberally educated mind. We are all familiar with the value placed on the word "critical" when it figures prominently in justifications for liberal arts pedagogy, as in "a liberal arts education should foster the capacity for critical thinking." However, depending on the milieu in which…

  18. The Effects of Prototypicality and Cultural Salience on Perceptions of People.

    ERIC Educational Resources Information Center

    Forgas, Joseph P.

    1983-01-01

    Studied person prototypes within a subcultural milieu and the influence of cultural salience on recall memory, predictions, and impression formation in two studies of college students. Results suggested that multiple information-processing strategies are used in person perception, influenced by normative and cultural variables. (WAS)

  19. Communication and Culture in Ancient India and China.

    ERIC Educational Resources Information Center

    Oliver, Robert T.

    The rhetorical theories and practices of ancient India and China provide the themes of this book. An examination of the relationship between culture and rhetoric, East and West, opens the book. The rhetorical milieu of India, its philosophy, social system, and uses of speech, leads to a probing of the caste system and speech of the Brahmins.…

  20. Investment and Disinvestment: Fiscal Resources for Blacks in Higher Education.

    ERIC Educational Resources Information Center

    Townsel, Alvin H.

    1983-01-01

    Traces economic milieu for higher education investments from the reconstruction period through the "Brown" era to the retrenchment era of the 1980's; describes federal, state, and institutional investment strategies and investment rates; and considers ways to aid in augmenting social and private returns to institutional higher education…

  1. Effect of probiotics and prebiotics on food animal immunity

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The gastrointestinal (GI) tract is the largest interface between an animal’s internal milieu and its exterior environment. As such, it forms a physical barrier between both environments. However, the function of the GI tract in the well-being of an animal is more complex than this passive role. Th...

  2. The effects of pre- and probiotics on the host immune response

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The gastrointestinal (GI) tract is the largest interface between an animal’s internal milieu and its exterior environment. As such, it forms a physical barrier between both environments. However, the function of the GI tract in the well-being of an animal is more complex than this passive role. T...

  3. Unit 1001: The Nature of Meaning in Language.

    ERIC Educational Resources Information Center

    Minnesota Univ., Minneapolis. Center for Curriculum Development in English.

    This 10th-grade unit in Minnesota's "language-centered" curriculum introduces the complexity of linguistic meaning by demonstrating the relationships among linguistic symbols, their referents, their interpreters, and the social milieu. The unit begins with a discussion of Ray Bradbury's "The Kilimanjaro Machine," which illustrates how an otherwise…

  4. The Language of Treatment: Argot in a Therapeutic Community

    ERIC Educational Resources Information Center

    Hoag, Patricia E.; And Others

    1977-01-01

    Though it is not known to what extent the cultural orientation revealed in the therapeutic community's argot facilitates treatment, it is likely that at least for those who accept its concept, the therapeutic community provides a milieu in which effective resocialization can take place. (Author)

  5. CULTURE SHOCK.

    ERIC Educational Resources Information Center

    WEINSTEIN, GERALD; AND OTHERS

    IN A PANEL, GEORGE BRAGLE AND NATHAN GOULD STRESS TEACHER PREPARATION TO COPE WITH THE THREATENING IMPACT OF CULTURE OR REALITY SHOCK. THEY RECOMMEND MODIFYING THE ATTITUDES OF TEACHERS BY ALTERING THEIR PERCEPTIONS, PROVIDING THEM WITH DIRECT EXPERIENCE WITH THE SOCIOCULTURAL MILIEU OF GHETTO SCHOOLS, AND REQUIRING THEM TO TAKE COURSES IN THE…

  6. How Students Experience and Navigate Transitions in Undergraduate Medical Education: An Application of Bourdieu's Theoretical Model

    ERIC Educational Resources Information Center

    Balmer, Dorene F.; Richards, Boyd F.; Varpio, Lara

    2015-01-01

    Using Bourdieu's theoretical model as a lens for analysis, we sought to understand how students experience the undergraduate medical education (UME) milieu, focusing on how they navigate transitions from the preclinical phase, to the major clinical year (MCY), and to the preparation for residency phase. Twenty-two medical students participated in…

  7. Self-Determination in Medical Education: Encouraging Medical Educators to Be More like Blues Artists and Poets

    ERIC Educational Resources Information Center

    Patrick, Heather; Williams, Geoffrey C.

    2009-01-01

    Historically, medical education has focused largely on medical students' intellectual development, mostly ignoring the broader psychological milieu of medical practice. This chasm can result in practitioners who are less likely to process their emotions and/or support their patient's needs, and more likely to experience burnout. Self-determination…

  8. Aligning Collaborative and Culturally Responsive Evaluation Approaches

    ERIC Educational Resources Information Center

    Askew, Karyl; Beverly, Monifa Green; Jay, Michelle L.

    2012-01-01

    The authors, three African-American women trained as collaborative evaluators, offer a comparative analysis of collaborative evaluation (O'Sullivan, 2004) and culturally responsive evaluation approaches (Frierson, Hood, & Hughes, 2002; Kirkhart & Hopson, 2010). Collaborative evaluation techniques immerse evaluators in the cultural milieu of the…

  9. "The Storyteller: Reflections on the Works of Nikolai Leskov."

    ERIC Educational Resources Information Center

    International Journal of Oral History, 1981

    1981-01-01

    Presents 11 selections from Walter Benjamin's essay "The Storyteller" which illustrate how the work milieu and the significance of death are incorporated into stories. Benjamin compares historiography to traditional storytelling, and discusses the effect of the storyteller's need to maintain the listener's interest upon the story's style and…

  10. A Transactional Model of Spoken Vocabulary Variation in Toddlers with Intellectual Disabilities

    ERIC Educational Resources Information Center

    Woynaroski, Tiffany; Yoder, Paul J.; Fey, Marc E.; Warren, Steven F.

    2014-01-01

    Purpose: The authors examined (a) whether dose frequency of milieu communication teaching (MCT) affects children's canonical syllabic communication and (b) whether the relation between early canonical syllabic communication and later spoken vocabulary is mediated by parental linguistic mapping in children with intellectual disabilities (ID).…

  11. Towards a Pedagogy of a New Social Contract: Lessons from the Participatory Budget in the State of Rio Grande do Sul (Brazil)

    ERIC Educational Resources Information Center

    Streck, Danilo Romeu

    2004-01-01

    The paper analyses the pedagogical dimension of the process of Participatory Budgeting in the State of Rio Grande do Sul (Brazil), taking into consideration the local and regional culture as well as the wider political milieu. The question this paper engages with is whether, in this social movement involving around 400,000 people in 2001, there…

  12. Towards a Pedagogy of a New Social Contract: Lessons from Participatory Budgeting in the State of Rio Grande do Sul (Brazil).

    ERIC Educational Resources Information Center

    Streck, Danilo R.

    This paper analyzes the pedagogical dimension within the process of participatory budgeting in the state of Rio Grande do Sul, Brazil, taking into consideration the local and regional culture, as well as the political milieu. The question is whether, in this social movement which involved around 400,000 people in 2001, signs can be identified that…

  13. Monitoring the Future: National Survey Results on Drug Use, 1975-2005. Volume 1: Secondary School Students, 2005. NIH Publication No. 06-5883

    ERIC Educational Resources Information Center

    Johnston, Lloyd D.; O'Malley, Patrick M.; Bachman, Jerald G.; Schulenberg, John E.

    2006-01-01

    This monograph provides the 1975-2005 national trends in smoking, drinking, and illicit drug use among American secondary school students. It covers subgroup differences, attitudes and beliefs about use, social milieu, degree and duration of drug highs, initiation rates, prevalence and frequency, and trends in illicit drug and alcohol use. Drug…

  14. OZONE DEPLETION AND THE AIR-SEA EXCHANGE OF GREENHOUSE AND CHEMICALLY REACTIVE TRACE GASES

    EPA Science Inventory

    One of the most important aspects of global change is that of stratospheric ozone depletion and the resulting increase in UV radiation reaching the surface of the Earth. Some 70% of the Earth surface is covered by water containing an extremely complicated milieu of organic and in...

  15. Pedagogy without Pedagogy: Dancing with Living, Knowing and Morale

    ERIC Educational Resources Information Center

    Chen, Rosa Hong

    2015-01-01

    This article takes its retrospective lead from the oppressive schooling years during the Chinese Cultural Revolution to reflect on the educational significance of artistic activities through considering aesthetic virtues and moral agency cultivated in these activities. Describing an unconventional educational milieu where schooling was…

  16. School-Parent Relations in Lebanon

    ERIC Educational Resources Information Center

    El Majzoub, Nada

    2013-01-01

    Lebanon is a nation whose history may be depicted as continuous social, political, and sectarian conflict due to European political meddling and a protracted civil war. Although finding common ground in this complex milieu over the past several decades has been challenging, political and educational reforms have been enacted. The role of parents…

  17. Ravishing or Ravaged: Women's Relationships with Women in the Context of Aging and Western Beauty Culture

    ERIC Educational Resources Information Center

    Gosselink, Carol A.; Cox, Deborah L.; McClure, Sarissa J.; De Jong, Mary L. G.

    2008-01-01

    We undertook this narrative analysis study to explore the complexities of women's relationships with other women within the sociocultural milieu of beautyism and ageism. Using an open-ended narrative framework, four focus groups of women living in different regions throughout the U.S. were conducted and analyzed to identify thematic categories…

  18. In Search of Saraswati: The Ambivalence of the Indian Academic

    ERIC Educational Resources Information Center

    Altbach, Philip G.

    1977-01-01

    The working conditions, attitudes, and organizational milieu of college teachers in India are examined based on a case study of the University of Bombay. Focus is on the ambivalent role of the college teacher as an individual with an inadequate income, declining social status, but the pretentions of professionalism. (Author/LBH)

  19. India: Financing of Elementary Education in India in the 1990s. South Asia Education Sector Technical Working Paper.

    ERIC Educational Resources Information Center

    Sipahimalani, Vandana

    This paper studies the trends in the financing of elementary education in India over the past decade. In 1994 the Indian Supreme Court issued a directive to universalize free and compulsory elementary education, but that in a changing economic milieu where social service expenditures have often been reduced in other countries, it is important to…

  20. Teacher Research and Other Research Communities: A Case for Desegregation.

    ERIC Educational Resources Information Center

    O'Flahavan, John F.

    The overall segregationist milieu of the educational enterprise serves to forestall movement in the search of a comprehensive theory of literacy and literacy instruction. Building such a theory mandates a democratically disposed, pluralistic research community. Sociologically, the theory-to-practice norm sustains an artificial hierarchy within the…

  1. The Scriptural Cantatas "Esther" and "Jacob, et Rachel" of Elisabeth-Claude Jacquet de La Guerre: Historical Context and Performance Practice

    ERIC Educational Resources Information Center

    Buckley, Elizabeth M.

    2009-01-01

    This project explores two sacred cantatas of Elisabeth-Claude Jacquet de La Guerre, "Esther" and "Jacob, et Rachel". The cultural milieu in which the sacred cantatas of Jacquet de La Guerre were written and performed will be discussed, as well as possible venues for their original performances, including the Parisian salon, and the Royale maison…

  2. Curriculum Development in the Postmodern Era. Garland Reference Library of Social Science, Volume 929. Critical Education Practice, Volume 1.

    ERIC Educational Resources Information Center

    Slattery, Patrick

    This book provides an introduction to the field of curriculum and instruction development as it relates to emerging postmodern education paradigms. The book discusses such terms as "curriculum development,""postmodernism,""hermeneutics,""paradigm,""chaos theory,""poststructuralism," and "critical theory" in the context of the educational milieu of…

  3. The Cognitive Enrichment Network Program: Goodness of Fit with At-Risk Gifted Students.

    ERIC Educational Resources Information Center

    Greenberg, Katherine H.; And Others

    1993-01-01

    The Cognitive Enrichment Network Educational Model (COGNET) is a comprehensive elementary school approach to assist children in becoming effective, independent, life-long learners, by using mediated learning to address each child's personal and cultural characteristics and social milieu. This paper describes the COGNET approach for nurturing…

  4. A Design for Professional Development of Teachers--Need for New Policy Framework

    ERIC Educational Resources Information Center

    Vasumathi, T.

    2010-01-01

    Teachers' professional development is not exclusively concerned with supporting teaching and knowledge. Support is required for teachers to reflect on their existing practice and adapt new knowledge and beliefs to their own teaching milieu. Therefore, design policies that support teachers are very vital for professional development. Knowledge on…

  5. Context and Critical Perspective: Meeting Black Autobiography Halfway.

    ERIC Educational Resources Information Center

    Davidson, Phebe

    Black autobiography can only be viewed sensibly in the classroom if an attempt is made to come to terms with the social and historical milieu in which the work was produced and with the persona and ethos of the writer. Critical failure to do so puts critic and text at a serious disadvantage because such failure restricts critical vision to the…

  6. Modeling Fear of Crime in Dallas Neighborhoods: A Test of Social Capital Theory

    ERIC Educational Resources Information Center

    Ferguson, Kristin M.; Mindel, Charles H.

    2007-01-01

    This study tested a model of the effects of different predictors on individuals' levels of fear of crime in Dallas neighborhoods. Given its dual focus on individual perceptions and community-level interactions, social capital theory was selected as the most appropriate framework to explore fear of crime within the neighborhood milieu. A structural…

  7. A "Prepaid Package" for Obstetrics: Effect on Teaching and Patient Care in a University Hospital

    ERIC Educational Resources Information Center

    Young, Philip E.

    1976-01-01

    The changing social milieu has removed the charity patient but not the need for a teaching population. The University Hospital's program is described, in which patients prepaid a fixed, single fee for all obstetrics-related care through the third post partum day. (LBH)

  8. Background Readings in American Education.

    ERIC Educational Resources Information Center

    Office of Education (DHEW), Washington, DC. Bureau of Research.

    This collection of readings was assembled and edited for use at the White House Conference on Education in Washington, D.C. on July 21st and 22nd, 1965. Some of the twenty-nine documents of historical value and relevance in today's educational milieu are: 1) Proposals Relating to the Education of Youth in Pennsylvania, Benjamin Franklin, 1749; 2)…

  9. Micro-Social Factors in the Development of Entrepreneurial Giftedness: The Case of Richard Branson

    ERIC Educational Resources Information Center

    Shavinina, Larisa V.

    2006-01-01

    Research shows that social circumstances influence the development of an individual's high abilities. This paper identifies the micro-social1 factors in the development of entrepreneurial giftedness. Specifically, the paper considers the family milieu, 'significant others' and great contemporaries in the case of Richard Branson, the most…

  10. Autochthonous Change: Self-Renewal through Open Software Design

    ERIC Educational Resources Information Center

    Hedbring, Charles

    2005-01-01

    In all likelihood, currently employed therapists and teachers grew up with computer technology. Part of their computer culture included programming computers for entertainment using popular consumer software like Microsoft Basic. Within this social-educational milieu, the "FACTS+" curriculum represents one long-term project covering the…

  11. Authoritarian Development.

    ERIC Educational Resources Information Center

    Mason, Edward S.

    1978-01-01

    While modernizing along Western economic lines, developing nations have not adopted Western political forms. But the evolution of democracy in Europe occurred in a different socioeconomic milieu. The authoritarian governments of the Third World, based on nationalism and centralization, may better meet current needs for modernization. (SJL)

  12. Effects of the Teach-Model-Coach-Review Instructional Approach on Caregiver Use of Language Support Strategies and Children's Expressive Language Skills

    ERIC Educational Resources Information Center

    Roberts, Megan Y.; Kaiser, Ann P.; Wolfe, Cathy E.; Bryant, Julie D.; Spidalieri, Alexandria M.

    2014-01-01

    Purpose: In this study, the authors examined the effects of the Teach-Model-Coach-Review instructional approach on caregivers' use of four enhanced milieu teaching (EMT) language support strategies and on their children's use of expressive language. Method: Four caregiver-child dyads participated in a single-subject, multiple-baseline…

  13. Mice fed a high-fat diet supplemented with resistant starch display marked shifts in the liver metabolome concurrent with altered gut bacteria

    Technology Transfer Automated Retrieval System (TEKTRAN)

    High-amylose maize resistant starch type 2 (HAMRS2) is a fermentable dietary fiber known to alter the gut milieu, including the gut microbiota, which may explain reported effects of resistant starch to ameliorate obesity-associated metabolic dysfunction. Our working hypothesis is that HAMRS2-induced...

  14. Shyness and the College Admission Process: Who is Being Left Out?

    ERIC Educational Resources Information Center

    Hanley, Jr., Thomas A.

    2005-01-01

    As professionals on both sides of the admission desk, there are several questions we should ask ourselves with regard to this issue. For example, do outgoing students make more positive contributions to the academic milieu and social fabric of a university than reserved students??or are their contributions simply more visible? Do college…

  15. Fostering Scholarship Capacity: The Experience of Nurse Educators

    ERIC Educational Resources Information Center

    Cash, Penelope A.; Tate, Betty

    2012-01-01

    In a milieu where traditional views of scholarship are embedded in the culture of educational institutions, and nursing programs in particular, this paper reports on a research project designed to support nurse educators' capacity to engage in scholarly activities. Rogers' (2003, 2004) "Diffusion of Innovation" model provided a theoretical vantage…

  16. Laptopers in an Educational Practice: Promoting the Personal Learning Situation

    ERIC Educational Resources Information Center

    Lindroth, Tomas; Bergquist, Magnus

    2010-01-01

    In this article an ethnographical study of laptopers' activities during lectures in a university milieu is analyzed as different kinds of involvements. Through interviews and observations we have focused on how these involvements influence the laptopers' alignment towards the educational practice. The analysis shows the importance of separating…

  17. Learning and Education in the Context of Social Milieus: The Risks and Benefits of Social and Cultural Capital.

    ERIC Educational Resources Information Center

    Barz, Heiner

    The benefits of and barriers to lifelong learning were examined in two studies of the relationship between social milieu and interest in, access to, and participation in adult education. The first study was conducted in Freiburg, Germany, in 1995-1998, and the second study was conducted in Munich, Germany, in 2000-2002. The Freiburg study focused…

  18. Conceptualizations of Human Environments

    ERIC Educational Resources Information Center

    Moos, Rudolf H.

    1973-01-01

    Presents six major methods by which characteristics of environments have been related to indexes of human functioning: (1) ecological dimensions; (2) behavior settings; (3) dimensions of organizational structure; and, (4) dimensions identifying the collective personal and/or behavioral characteristics of the milieu inhabitants; and two others.…

  19. Reforming U.S. Education for the Academic Study of Religion

    ERIC Educational Resources Information Center

    Waggoner, Michael D.

    2011-01-01

    Religion and spirituality are gaining renewed appreciation as key elements of the cultural milieu. Yet there has been an inattention to the academic study of religion and spirituality in U.S. education due to several contributing causes. Central to remediating this deficiency is an understanding of these causes and how the reform of key factors in…

  20. Sustainability Science Education in Africa: Negotiating Indigenous Ways of Living with Nature in the Third Space

    ERIC Educational Resources Information Center

    Glasson, George E.; Mhango, Ndalapa; Phiri, Absalom; Lanier, Marilyn

    2010-01-01

    In response to global climate change, loss of biodiversity, and the immense human impact on the carrying capacity of the earth systems, attention has been given to sustainable development worldwide. In this paper, we explore the emerging field of sustainability science within the context of the socio-cultural milieu of Malawi, a sub-Saharan…

  1. The KIDTALK Behavior and Language Code: Manual and Coding Protocol.

    ERIC Educational Resources Information Center

    Delaney, Elizabeth M.; Ezell, Sara S.; Solomon, Ned A.; Hancock, Terry B.; Kaiser, Ann P.

    Developed as part of the Milieu Language Teaching Project at the John F. Kennedy Center at Vanderbilt University in Nashville, Tennessee, this KIDTALK Behavior-Language Coding Protocol and manual measures behavior occurring during adult-child interactions. The manual is divided into 5 distinct sections: (1) the adult behavior codes describe…

  2. Interpersonal problem solving: a theoretical perspective and methodology for the evaluation of residency education and its' relationship to health care processes and outcomes.

    PubMed

    Hogan, M J; Sirotkin, R A; Ticknor, M C; Harm, J; Foulds, D M; Scalzi, P; Gallagher, R E

    1977-01-01

    The study conceptualizes and implements an interaction model of interpersonal problem solving in the clinical milieu. This method of representing the interpersonal problem solving process and its relation to patient adherence is shown as an important tool for the evaluation of residency programs.

  3. Matching the Student with the Most Appropriate Assistive Technology: Evaluation of the Assistive Technology Device Predisposition Assessment (ATD PA).

    ERIC Educational Resources Information Center

    Scherer, Marcia J.; McKee, Barbara G.

    To those who look to technology to enhance a person's quality of life and not merely to restore capability, it is more important and cost effective to consider environmental modifications and the functions of devices within a comprehensive context of varying situations (Milieu characteristics); user interests, needs, capabilities, expectations,…

  4. Faculty Development Curriculum: What Informs It?

    ERIC Educational Resources Information Center

    Elliott, Robert W.

    2014-01-01

    With the current milieu of current legislation and continued budget reductions for higher education, institutions are faced with being more creative in their efforts to reduce spending while achieving their stated mission. The purpose of this paper is to inform college administrators and faculty about the sources used to inform faculty development…

  5. Filtering Shakespeare Teaching through Curricular Commonplaces

    ERIC Educational Resources Information Center

    Rice, Mary

    2012-01-01

    Schwab (1978) argued that curriculum emerged in the commonplaces of teacher, learner, subject matter and milieu. It was in these four frames that I narratively explored my own development as an English teacher and curriculum planner around Shakespeare's work, particularly "The Tragedy of Romeo and Juliet." In this narrative, I relate four…

  6. Argumentation in the Canadian House of Commons on the Issue of Nuclear Weapons for Canada.

    ERIC Educational Resources Information Center

    Jones, John Alfred

    The Cuban missile crisis of October 1962 forced the Canadian House of Commons to consider whether Canadian forces in NORAD and NATO were effective without nuclear warheads on special weapons systems. This paper provides an overview of the debates and their milieu, identifies the issues involved, and analyzes the effects of the argumentation. The…

  7. The Role of Sexual Trauma in the Treatment of Chemically Dependent Women: Addressing the Relapse Issue.

    ERIC Educational Resources Information Center

    Wadsworth, Rick; And Others

    1995-01-01

    Explores issues surrounding sexual trauma and chemical dependency. Aims to provide direction for relapse prevention with a relapse-prone population and explores application of traditional milieu substance-abuse treatment for sexual-trauma survivors. Makes recommendations for working with sexual-trauma survivors who are also substance abusers. (RJM)

  8. Heidegger, Digital Technology, and Postmodern Education: From Being in Cyberspace to Meeting on MySpace

    ERIC Educational Resources Information Center

    Walters, Patrick; Kop, Rita

    2009-01-01

    Digital technology is transforming life and is beginning to have a profound effect on individual psychic life and the wider social milieu. This article seeks to understand the nature of the new technology and its implications for personal life, culture, and education. The scene is set by comparing the introduction of printing to the revolution…

  9. "Outstanding Individuals Do Not Arise from Ancestrally Poor Stock": Racial Science and the Education of Black South Africans.

    ERIC Educational Resources Information Center

    Appel, Stephen W.

    1989-01-01

    Examines the construction of racial scientific discourse within the milieu of an extremely racially segregated society. Traces the influence of capitalism, racism, Social Darwinism, eugenics, and "racial science" on the pedagogy of modern apartheid in South Africa. Finds evidence of pervasive effects of "scientific" ideas on public policy and…

  10. Evangelizing Eugenics: A Brief Historiography of Popular and Formal American Eugenics Education (1908-1948)

    ERIC Educational Resources Information Center

    Kohlman, Michael J.

    2012-01-01

    This article examines the history of the American Eugenics movement's penetration into the formal and popular educational milieu during the first half of the 20th Century, and includes a review of some recent scholarly research on eugenic themes in education and popular culture. Apologists have dismissed the American Eugenics movement as a…

  11. Effects of Dose Frequency of Early Communication Intervention in Young Children with and without Down Syndrome

    ERIC Educational Resources Information Center

    Yoder, Paul; Woynaroski, Tiffany; Fey, Marc; Warren, Steven

    2014-01-01

    Children with intellectual disability were randomly assigned to receive Milieu Communication Teaching (MCT) at one 1-hr session per week (low dose frequency, LDF) or five 1-hr sessions per week (high dose frequency, HDF) over 9 months (Fey, Yoder, Warren, & Bredin-Oja, 2013. Non-Down syndrome (NDS) and Down syndrome (DS) subgroups were matched…

  12. Geographic Considerations in International Studies.

    ERIC Educational Resources Information Center

    Kott, Richard F.

    Based on students' generally shallow knowledge of geographic concepts on the one hand and a new and almost universal awareness of man in his milieu on the other, the author seeks to draw attention to the discipline of geography, and more specifically, political geography as an essential, fundamental component of international studies. The…

  13. Walking around the Curriculum Tree: An Analysis of a Third/Fourth-Grade Mathematics Lesson

    ERIC Educational Resources Information Center

    Ross, Vicki

    2003-01-01

    This study, part of a narrative classroom inquiry into the teaching and learning of mathematics in a Canadian elementary classroom, emerges from the three years I was a participant-observer in Janine O'Neil's 3rd/4th-grade classroom at Bay Street Community School. Drawing on the curriculum commonplaces of teacher, social milieu, subject matter,…

  14. Emotional Sequelae of Abortion: Implications for Clinical Practice.

    ERIC Educational Resources Information Center

    Lemkau, Jeanne Parr

    1988-01-01

    Summarizes literature on normative reactions to abortion and factors that increase risk of negative emotional sequelae. Discusses characteristics of woman, social support and cultural milieu around the abortion, the medical environment and abortion procedure itself, and events subsequent to abortion which may cause conflict. Discusses implications…

  15. Issues in International Bilingual Education: The Role of the Vernacular.

    ERIC Educational Resources Information Center

    Hartford, Beverly, Ed.; And Others

    The fifteen articles in this volume are generally concerned with the role of vernacular language in bilingual education on an international scale. They examine specific nations and how bilingualism affects their social milieu. The following articles are included: (1) "Bilingualism and the Vernacular," by Shana Poplack; (2) "The Bilingual's…

  16. Connoisseurship in an Age of Distractions

    ERIC Educational Resources Information Center

    Hope, Samuel

    2002-01-01

    Today, "connoisseurship" conjures up images of fusty old men in tweeds arguing over ancient etchings or perhaps the patter of opera buffs as they pass bejeweled into the night. Connoisseurship is neither fashionable nor politically correct. It signifies a focus on works of art rather than issues of power and is foreign to a cultural milieu where…

  17. Prolepsis, Syncretism, and Synergy in Early Language and Literacy Practices: A Case Study of Family Language Policy in Singapore

    ERIC Educational Resources Information Center

    Ren, Li; Hu, Guangwei

    2013-01-01

    This article reports a case study of two Chinese-English bilingual families in Singapore and illustrates the importance of incorporating two hitherto disconnected fields of research--family language policy and family literacy practices--to an understanding of early language and literacy acquisition in the familial milieu. Specifically, this work…

  18. Traditional & Socio-Cultural Barriers to EFL Learning: A Case Study

    ERIC Educational Resources Information Center

    Ahmad, Jameel

    2015-01-01

    This research tends to ascertain several traditional and socio-cultural barriers to English language learning in Saudi Arabia and to explore more ways than before for making teaching and learning more effective. The findings of four quantitative and qualitative surveys conducted in this regard reveal a unique traditional and socio-cultural milieu,…

  19. A Case for Inserting Community into Public School Curriculum

    ERIC Educational Resources Information Center

    Theobald, Paul

    2006-01-01

    This essay contends that there are fundamental connections between a nation's political arrangements and its educational efforts on behalf of youth. Though the common school architects of the nineteenth century recognized these connections, they were profoundly forgotten in a later Darwinian milieu that suggested--our allegiance to democracy…

  20. A Retrospective Examination of a University's Thirteen Years in Latin America.

    ERIC Educational Resources Information Center

    Blood, Ronald E.; And Others

    The context of educational reform within which U.S. higher education has worked in selected Latin American countries is examined, with attention directed to the specific experience of the University of New Mexico. The evolution of the Latin American Programs in Education office (LAPE) in the university setting, the organizational milieu in which…

  1. A Reflective Conversation with Kobus Maree, Faculty of Education, University of Pretoria, South Africa

    ERIC Educational Resources Information Center

    Shaughnessy, Michael F.; Moore, Tammy Lynne; Maree, Kobus

    2013-01-01

    Always regarded as somewhat of an "outsider" (the child of an English-speaking (Catholic) mother and an Afrikaans (Protestant) father in an exclusively Afrikaans milieu) and growing up extremely poor, seeing the hardship of others and realising how much talent was going to waste, Kobus Maree took a particular interest in gifted disadvantaged…

  2. Le Certificat Pratique de la CCIP et la Traduction dans les Cours de francais Commercial (The CCIP Certificate and Translation in Business French Courses).

    ERIC Educational Resources Information Center

    Cote, Paul Raymond

    1996-01-01

    Discusses the importance of professional translators in the milieu of the European Community and the global economy. The article focuses on the changes occurring within the French educational system in order to accomodate this reality by preparing students for a practical translation test in order to earn a certificate in the translation of…

  3. "Animation Sociale": The Experience of the BAEQ. Condensed Report.

    ERIC Educational Resources Information Center

    Morency, Marc-A.

    To promote popular participation as a means and goal of community development, the Bureau d'Amenagement de l'Est du Quebec (BAEQ) had to work within a milieu that favored traditional power structures over social participation in decision making. Phase 1 (May-September 1963) of this project was mainly a time for recruiting and training change…

  4. Language Policy in Canada: Current Issues. A Selection of the Proceedings of the Papers Dealing with Language Policy Issues in Canada at the Conference "Language Policy and Social Problems" (Curacao, Venezuela, December, 1983). Publication B-150.

    ERIC Educational Resources Information Center

    Cobarrubias, Juan, Ed.

    The papers related to Canadian language policy at an international conference are presented: "Language Policy in Canada: Current Issues" (Juan Cobarrubias); "Multiculturalism and Language Policy in Canada" (Jim Cummins, Harold Troper); "Defining Language Policy in a Nationalistic Milieu and in a Complex Industrialized Region: the Quebec Case"…

  5. Positive Emotions: Passionate Scholarship and Student Transformation

    ERIC Educational Resources Information Center

    Beard, Colin; Humberstone, Barbara; Clayton, Ben

    2014-01-01

    This paper challenges the practical and conceptual understanding of the role of emotions in higher education from the twin perspectives of transition and transformation. Focusing on the neglected area of positive emotions, exploratory data reveal a rich, low-level milieu of undergraduate emotional awareness in students chiefly attributed to…

  6. Internal-External Locus of Control in Middle and Later Life: The Search for Construct Validation.

    ERIC Educational Resources Information Center

    Bielby, Denise D.; Siegler, Ilene C.

    This study validates the developmental nature of internal-external locus of control in middle and old age. Longitudinal stability of locus of control in the face of particular changes in social milieu common during the transition from middle to late life was contrasted with that of verbal intelligence, a known stable characteristic, and that of…

  7. L'interdisciplinarite en sciences sociales pour l'etude du contact des langues (Interdisciplinarity in Social Sciences of the Study of the Relationships of Languages). Proceedings of a Colloquium of the International Center for Research on Bilingualism and the Institute for Interethnic and Intercultural Studies and Research (2nd, Quebec City, Quebec, Canada, October 1-5, 1984).

    ERIC Educational Resources Information Center

    Prujiner, Alain, Ed.

    Papers given at an international conference applying the social sciences to the study of the relationships of languages include the following: "Reseaux sociaux et comportements langagiers en milieu de contact des langues" ("Social Networks and Language Behaviors in a Language Contact Setting") by M. Blanc and J. Hamers, with commentary by R.…

  8. Learning To Be Remedial: Constructing the Meaning of Literacy in High School English Classes.

    ERIC Educational Resources Information Center

    Randlett, Alice Schmatz

    A study examined the view of literacy as a socially constructed phenomenon situated within a culturally reproductive milieu. Within the context of one medium-sized comprehensive high school in a small city in the Midwest, the focus was on the daily classroom practice in teaching and learning to read and write. Four separate classes--two low track,…

  9. What the West Could Learn from the East: A Reflective Analysis

    ERIC Educational Resources Information Center

    Zou, Yali; Craig, Cheryl J.; Poimbeauf, Rita P.

    2016-01-01

    Drawing on Lugones' ideas of world traveling, Dewey's notion of education as experience, and Greene's vision of seeing small/seeing big, this article inquires into lives lived in an Eastern educational milieu with attention reflectively paid to what educators in the West could learn from those in the East. Rather than focusing on mega narratives…

  10. Enhancing Reflective Practice in Multicultural Counseling through Cultural Auditing

    ERIC Educational Resources Information Center

    Collins, Sandra; Arthur, Nancy; Wong-Wylie, Gina

    2010-01-01

    Counselors work in an increasingly complex cultural milieu where every encounter with a client must be considered multicultural in nature. Reflective practice is a central component of professional competence and necessarily involves attention to culture. The cultural auditing model provides an effective and flexible reflective process for…

  11. Forgotten Pioneers in the Study of Gifted African-Americans.

    ERIC Educational Resources Information Center

    Kearney, Katheryn; LeBlanc, Jene

    1993-01-01

    This paper discusses the work of five scholars who sought to establish a literature about gifted African-American children--Horace Mann Bond, Lillian Proctor, A. Janet Terwilliger, Martin David Jenkins, and Viola Theman. The paper also discusses the social milieu in which the scholars worked and possible reasons for the neglect of their research.…

  12. Socio-Economic Implications of Research for Pre-School Training Programs.

    ERIC Educational Resources Information Center

    John, Martha Tyler; Nksibandze, E. Nokulunga

    The primary objective of this research was to provide fundamental information about the relationship between social milieu, preschool experience, and children's ability to perform logical thinking tasks, and also about the implications of these factors for educational programs pertaining to the development of preschool teachers and administrators.…

  13. Television and Social Behavior; Reports and Papers, Volume I: Media Content and Control.

    ERIC Educational Resources Information Center

    Comstock, George A., Ed.; Rubinstein, Eli A., Ed.

    Six studies and an overview focus on the amount and character of the violence portrayed on television (TV), the circumstances and milieu in which this violent fare is created, and the formal and informal influences which affect the selection and prohibition of TV content. The overview serves as an introduction to the six studies and summarizes…

  14. Moral Courage from the Perspective of Arab Teachers in Jewish Schools

    ERIC Educational Resources Information Center

    Baratz, Lea

    2016-01-01

    The current study aims to call attention to the phenomenon of female Muslim Arab teachers teaching in Israeli Jewish schools. The study examined the manner in which these female Muslim Arab teachers perceived their integration into the milieu of the Jewish schools, based on their descriptions of the various processes they experience when dealing…

  15. Exploring the Utility of Self-Modeling in Decreasing Disruptive Behavior in Students with Intellectual Disability

    ERIC Educational Resources Information Center

    Bilias-Lolis, Evelyn; Chafouleas, Sandra M.; Kehle, Thomas J.; Bray, Melissa A.

    2012-01-01

    Students with intellectual disabilities can exhibit a wide array of challenging behaviors in the classroom that pose disruptions to the learning milieu and management problems for those involved in their education. Self-modeling, a behavioral intervention that involves viewing edited videotapes of oneself depicting exemplary behavior, has had…

  16. Knowledge Production through Interdisciplinary Skills: Producing an Effective Postgraduate Research Curriculum

    ERIC Educational Resources Information Center

    Chitakunye, Pepukayi; Takhar-Lail, Amandeep

    2015-01-01

    This study contributes to existing methodological knowledge by showing how a transformed research methods curriculum, which is beyond the milieu of schooling, can engage postgraduate students in a critical dialogue on how knowledge is produced in industry and higher education. Initial insights are drawn from two interpretive studies that employed…

  17. Industry Perceptions of Industry-University Partnerships Related to Doctoral Education in South Africa

    ERIC Educational Resources Information Center

    Herman, Chaya

    2013-01-01

    An assessment of the extent to which industry-university partnerships in doctoral education, which have become increasingly prevalent in the knowledge economy, have begun to penetrate the South African higher education milieu, is reported. The factors that motivate large industries in developing countries such as South Africa to invest in doctoral…

  18. Attaining Visual Literacy Using Simplified Graphics in Industry.

    ERIC Educational Resources Information Center

    Burton, Terry

    In the current milieu of ISO 9000 certification, just-in-time engineering (JIT), demand flow technology (DFT), and total quality management (TQM), industry is attempting to implement available technology for the creation, control, and delivery of documentation. In most cases, their efforts are in need of outside resources to analyze, develop,…

  19. Everyday ethics in the care of elderly people.

    PubMed

    Bolmsjö, Ingrid Agren; Sandman, Lars; Andersson, Edith

    2006-05-01

    This article analyses the general ethical milieu in a nursing home for elderly residents and provides a decision-making model for analysing the ethical situations that arise. It considers what it means for the residents to live together and for the staff to be in ethically problematic situations when caring for residents. An interpretative phenomenological approach and Sandman's ethical model proved useful for this purpose. Systematic observations were carried out and interpretation of the general ethical milieu was summarized as 'being in the same world without meeting'. Two themes and four subthemes emerged from the analysis. Three different ethical problems were analysed. The outcome of using the decision-making model highlighted the discrepancy between the solutions used and well-founded solutions to these problems. An important conclusion that emerged from this study was the need for a structured tool for reflection. PMID:16711184

  20. Role of orexins in the hypothalamic-pituitary-ovarian relationships.

    PubMed

    Silveyra, P; Cataldi, N I; Lux-Lantos, V A; Libertun, C

    2010-03-01

    Appropriate nutritional and vigilance states are needed for reproduction. In previous works, we described the influence of the hormonal milieu of proestrus on the orexinergic system and we found that orexin receptor 1 expression in the hypothalamus, but not other neural areas, and the adenohypophysis was under the influence of oestradiol and the time of the day. Information from the sexual hormonal milieu of proestrous afternoon impacts on various components of the orexinergic system and alertness on this particular night of proestrus would be of importance for successful reproduction. In this review, we summarize the available experimental data supporting the participation of orexins in the hypothalamic-pituitary-ovarian relationships. All together, these results suggest a role of the orexinergic system as an integrative link among vital functions such as reproduction, food intake, alertness and the inner biological clock.

  1. The imperative of strategic alignment across organizations: the experience of the Canadian Cancer Society's Centre for Behavioural Research and Program Evaluation.

    PubMed

    Cameron, Roy; Riley, Barbara L; Campbell, H Sharon; Manske, Stephen; Lamers-Bellio, Kim

    2009-01-01

    The Canadian Cancer Society's Centre for Behavioural Research and Program Evaluation (CBRPE) is a national asset for building pan-Canadian capacity to support intervention studies that guide population-level policies and programs. This paper briefly describes CBRPE's experience in advancing this work in the field of prevention. The aim is to illuminate issues of central importance for advancing the goals of the Population Health Intervention Research Initiative for Canada. According to our experience, success in building the population intervention field will depend heavily on purposeful alignment across organizations to enable integration of research, evaluation, surveillance, policy and practice. CBRPE's capacity development roles include a) a catalytic role in shaping this aligned inter-organizational milieu and b) investing our resources in building tangible assets (teams, indicators, data systems) that contribute relevant capacities within this emerging milieu. Challenges in building capacity in this field are described.

  2. Immunity by equilibrium.

    PubMed

    Eberl, Gérard

    2016-08-01

    The classical model of immunity posits that the immune system reacts to pathogens and injury and restores homeostasis. Indeed, a century of research has uncovered the means and mechanisms by which the immune system recognizes danger and regulates its own activity. However, this classical model does not fully explain complex phenomena, such as tolerance, allergy, the increased prevalence of inflammatory pathologies in industrialized nations and immunity to multiple infections. In this Essay, I propose a model of immunity that is based on equilibrium, in which the healthy immune system is always active and in a state of dynamic equilibrium between antagonistic types of response. This equilibrium is regulated both by the internal milieu and by the microbial environment. As a result, alteration of the internal milieu or microbial environment leads to immune disequilibrium, which determines tolerance, protective immunity and inflammatory pathology.

  3. Another day older and deeper in therapy: Can the Dynamic-Maturational Model offer a way out?

    PubMed

    Wilkinson, Simon R

    2010-07-01

    Patients referred to adolescent psychiatric units have often been in contact with services for many years. When assessing for admission we consider why the previous approaches might have failed and how milieu therapy might be more effective as the priority treatment. We propose that the information provided by an adolescent's Transition to Adulthood Attachment Interview (TAAI) and the parents' Adult Attachment Interviews (AAI) leads to an especially productive case formulation. The Dynamic-Maturational Model of attachment and adaptation (DMM) uniquely provides a detailed understanding of an extended range of Type A and Type C strategies with modifiers that are useful for planning the milieu therapy, individual and family work. In addition, this case presentation illustrates the usefulness of understanding the phenomenon of "intruded negative affect". PMID:20603428

  4. Gene Deletion of VIP Leads to Increased Mortality Associated with Progressive Right Ventricular Hypertrophy

    PubMed Central

    Szema, Anthony M.; Hamidi, Sayyed A.

    2014-01-01

    Vasoactive Intestinal Peptide (VIP) knockout mice exhibit asthma, pulmonary hypertension, and left ventricular wall thinning. Humans with these disorders have premature death. We show here that VIP KO mice have reduced survival (100% mortality at 20 months), vs. 100% survival among WT C57BL/6 mice. Moreover, the ratios of weights of right ventricle divided by left ventricle plus septum were progressively increased in VIP KO mice with age. Core temperatures were lower in VIP KO mice when compared to WT littermates, with an associated pro-inflammatory cytokine milieu. Overall, our results indicate that VIP is important for survival in mice. Its absence leads to increased mortality, with progressive right ventricular hypertrophy as a surrogate of pulmonary hypertension, lower body weight, hypothermia, and pro-inflammatory milieu. These studies support VIP as a novel therapeutic agent in pulmonary hypertension. PMID:24860842

  5. Electron microscope observations of impact crater debris amongst contaminating particulates on materials surfaces exposed in space in low-Earth orbit

    NASA Technical Reports Server (NTRS)

    Murr, L. E.; Rivas, J. M.; Quinones, S.; Niou, C.-S.; Advani, A. H.; Marquez, B.

    1993-01-01

    Debris particles extracted from a small sampling region on the leading edge of the Long Duration Exposure Facility (LDEF) spacecraft have been examined by analytical transmission electron microscopy and the elemental frequency observed by energy-dispersive X-ray spectrometry and compared with upper atmosphere (Earth) particle elemental frequency and the average elemental compositions of interplanetary dust particles. A much broader elemental distribution was observed for the exposed spacecraft surface debris milieu. Numerous metal microfragment analyses, particularly aluminum and stainless steel, were compared with scanning electron microscope observations-of impact crater features, and the corresponding elemental spectra on selected LDEF aluminium tray clamps and stainless steel bolts. The compositions and melt features for these impact craters and ejecta have been shown to be consistent with microcrystalline debris fragments in the case of aluminum, and these observations suggest an ever changing debris milieu on exposed surfaces for space craft and space system materials.

  6. Improving Awareness of an Acute Psychiatric Unit's Capacity for Admission.

    PubMed

    Benolkin, Lauren; Kinstler, Dan; Delaney, Kathleen R

    2015-08-01

    New admissions to psychiatric inpatient units can significantly impact the environment and level of safety. Maintaining safety is a core and critical responsibility of nursing, but nurses are often overlooked in the decision to admit a patient. Missed opportunities for dialogue between nurses and the admitting physician challenge nurses' ability to proactively manage the therapeutic environment. When nurses are limited in this ability, the outcome can be an unpredictable and unstable milieu. In a 25-bed acute psychiatric inpatient unit, a formalized communication system among the multidisciplinary admission team was developed. Data collected over 1 year demonstrated improved safety. Increasing the admitting provider's awareness of the current unit acuity and involving the nursing staff early in the admission process improved collaboration among care team members and reduced risks to maintaining milieu safety. PMID:26268479

  7. B lymphocyte immune response gene phenotype is genetically determined

    SciTech Connect

    Tse, H.Y.; Mond, J.J.; Longo, D.L.

    1982-04-01

    We examined the effects of the developmental milieu on the capacity of B cells to undergo immune response gene-controlled, T cell-dependent polyclonal proliferation. Although I-Aq poly(Glu60 Ala30 Tyr10)n (GAT)-nonresponder T cells developing in a responder environment become phenotypic GAT-responders, I-Aq B cells remain unresponsive to GAT, even after maturation in a GAT-responder animal. Conversely, (B10.A x B10.Q)F1 ((GAT responder x GAT nonresponder)F1) T cells developing in a B10.Q GAT nonresponder host fail to respond to GAT, but F1 B cells from the same F1 leads to parent chimeras make excellent proliferative responses in the presence of GAT and responder T cells. Thus, by this assay, B cell immune response gene function is genetically determined and is not affected by the developmental milieu.

  8. Tissue stroma as a regulator of leukocyte recruitment in inflammation.

    PubMed

    McGettrick, Helen M; Butler, Lynn M; Buckley, Chris D; Rainger, G Ed; Nash, Gerard B

    2012-03-01

    The stromal milieu (cellular and matrix components) helps establish tissue "address-codes" that direct leukocyte behavior in inflamed tissue. Coordinated interactions among the stroma, leukocytes, and ECs dictate which leukocytes are recruited, whether they are retained within the inflamed site, and how long they survive. Herein, we discuss how the stromal milieu influences the leukocyte recruitment cascade. Moreover, we explore how corruption of the stromal phenotype in chronic inflammatory diseases contributes to undesired, continuous recruitment of leukocytes. Emerging complex, multicellular, multilayered (co-)culture models are now addressing the molecular circuitry involved in regulating stromal organization during inflammation. Understanding context-specific changes in pro- or anti-inflammatory agents derived from the stroma, such as IL-6 (and its cofactors), is important for the generation of therapeutic strategies that restore the balance between recruitment and clearance of the inflammatory infiltrate in chronic disease.

  9. ?Drop-out? in the Danish high school (gymnasium): An investigation of psychological, sociological and pedagogical factors

    NASA Astrophysics Data System (ADS)

    Dohn, Helge

    1991-12-01

    The aim of the study was to investigate characteristics differentiating high-school students who had dropped out of school from those who remained. The study examined the relationship between drop-out and the following three clusters: (1) the effect of family background factors; (2) the effect of social factors in the educational milieu; and (3) the effect of motivation, achievement and ability. It was concluded that neither the effect of family background nor exposure to factors in the educational milieu were significant in the decision to finish school. One of the main conclusions of the investigation was that drop-out was associated with lack of motivation and achievement of the students.

  10. The effects of light on man and other mammals

    NASA Technical Reports Server (NTRS)

    Wurtman, R. J.

    1975-01-01

    The present article describes the best-studied extravisual effects of visible and ultraviolet light on humans and other mammals. It also considers the possible biological consequences to man of living in artificially lighted environments that differ significantly from the milieu in which he evolved. Cumulative evidence favors the beneficial influences of sunlight: vitamin D activation, plasma bilirubin elimination, inhibition of pineal melatonin synthesis, etc.

  11. Swapnaushadhi: the embedded logic of dreams and medical innovation in Bengal.

    PubMed

    Mukharji, Projit Bihari

    2014-09-01

    Numerous medicines in South Asia have their origins in dreams. Deities, saints and other supernatural beings frequently appear in dreams to instruct dreamers about specific remedies, therapeutic techniques, modes of care etc. These therapies challenge available models of historicising dreams. Once we overcome these challenges and unearth the embedded logic of these dreams, we begin to discern in them a dynamic institution that enabled and sustained therapeutic change within a 'traditional' medical milieu.

  12. Medical Examination and Poor Relief in Early Modern Germany

    PubMed Central

    Hammond, Mitchell Lewis

    2011-01-01

    Summary This article investigates the role of the medical examination in municipal poor relief programmes between 1570 and 1620. Documents from the city of Nördlingen, a community of approximately 10,000 people in 1600, suggest that municipal facilities addressed a range of serious illnesses for a wide spectrum of the population. Practitioners were influenced by their Galenic medical milieu but ultimately focused on a range of practical resource questions rather than the diagnosis of an individual's disease.

  13. Ian Curtis: Punk rock, epilepsy, and suicide.

    PubMed

    Tuft, Mia; Gjelsvik, Bergljot; Nakken, Karl O

    2015-11-01

    Ian Curtis was the front man of the post-punk band Joy Division. He suffered from epilepsy and actively incorporated his experiences of the disease in his lyrics. Curtis had frequent epileptic seizures, both on and off stage. After dying from suicide in 1980, he became a legend in the post-punk milieu. The impact which the epilepsy, the epilepsy treatment, and comorbid depression had on his artistic life and premature death is not well known.

  14. [The significance of Ptolemy's Almagest for its early readers].

    PubMed

    Bernard, Alain

    2010-01-01

    The paper explores the historical reasons why Ptolemy's Almagest was cultivated in Antiquity as a legitimate part of ancient culture. It tries to elucidate first the precise nature of Ptolemy's project in the Almagest, its relation to ethics as well as to the particular conception that Ptolemy had of mathematics. It then proposes an explanation for the fact that this treatise, both in Ptolemy's period and afterwards, was studied within the milieu of ancient astrologers.

  15. Letter to Freud: on the plight of psychoanalysis.

    PubMed

    Mendes, Dinah M

    2011-12-01

    In the form of a letter, the writer communicates to Freud her appreciation for the incomparable richness and complexity of the psychoanalytic enterprise in its century-long evolution from classical, Freudian origins to new developments in theory and technique. At the same time, concern is expressed about the continuity and survival of psychoanalysis in a cultural milieu that has absorbed its once radical ideas about sexuality and unconscious motivation while resisting its viability as a method of treatment.

  16. Murderous parents.

    PubMed

    Palermo, George B

    2002-04-01

    This article offers observations regarding some of the major manifestations of family violence, neonaticide, infanticide, and filicide with the purpose of aiding in the early identification of parents at risk. They are discussed within the past and present historical and cultural milieu. A brief review of pertinent literature is presented. Pertinent case studies from the forensic psychiatric practice of the author along with psychodynamic reflections are offered. PMID:12113159

  17. Fibroblasts as Efficient Antigen-Presenting Cells in Lymphoid Organs

    NASA Astrophysics Data System (ADS)

    Kundig, Thomas M.; Bachmann, Martin F.; Dipaolo, Claudio; Simard, John J. L.; Battegay, Manuel; Lother, Heinz; Gessner, Andre; Kuhlcke, Klaus; Ohashi, Pamela S.; Hengartner, Hans; Zinkernagel, Rolf M.

    1995-06-01

    Only so-called "professional" antigen-presenting cells (APCs) of hematopoietic origin are believed capable of inducing T lymphocyte responses. However, fibroblasts transfected with viral proteins directly induced antiviral cytotoxic T lymphocyte responses in vivo, without involvement of host APCs. Fibroblasts induced T cells only in the milieu of lymphoid organs. Thus, antigen localization affects self-nonself discrimination and cell-based vaccine strategies.

  18. Cyanide does more to inhibit heme enzymes, than merely serving as an active-site ligand.

    PubMed

    Parashar, Abhinav; Venkatachalam, Avanthika; Gideon, Daniel Andrew; Manoj, Kelath Murali

    2014-12-12

    The toxicity of cyanide is hitherto attributed to its ability to bind to heme proteins' active site and thereby inhibit their activity. It is shown herein that the long-held interpretation is inadequate to explain several observations in heme-enzyme reaction systems. Generation of cyanide-based diffusible radicals in heme-enzyme reaction milieu could shunt electron transfers (by non-active site processes), and thus be detrimental to the efficiency of oxidative outcomes.

  19. [The significance of Ptolemy's Almagest for its early readers].

    PubMed

    Bernard, Alain

    2010-01-01

    The paper explores the historical reasons why Ptolemy's Almagest was cultivated in Antiquity as a legitimate part of ancient culture. It tries to elucidate first the precise nature of Ptolemy's project in the Almagest, its relation to ethics as well as to the particular conception that Ptolemy had of mathematics. It then proposes an explanation for the fact that this treatise, both in Ptolemy's period and afterwards, was studied within the milieu of ancient astrologers. PMID:21222068

  20. Sir Paul Nurse.

    PubMed

    Birmingham, K

    2001-11-01

    Prizes in science don't come any bigger than the Nobels, and more often than not this award catapults its recipients from the general research milieu into the realms of scientific stardom. In this, its centenary year, the Nobel committee for Physiology or Medicine decided to honor investigators who have identified vital components of the cell cycle. Nature Medicine talked to one of the winners, Sir Paul Nurse. PMID:11689871

  1. Swapnaushadhi: the embedded logic of dreams and medical innovation in Bengal.

    PubMed

    Mukharji, Projit Bihari

    2014-09-01

    Numerous medicines in South Asia have their origins in dreams. Deities, saints and other supernatural beings frequently appear in dreams to instruct dreamers about specific remedies, therapeutic techniques, modes of care etc. These therapies challenge available models of historicising dreams. Once we overcome these challenges and unearth the embedded logic of these dreams, we begin to discern in them a dynamic institution that enabled and sustained therapeutic change within a 'traditional' medical milieu. PMID:24990459

  2. Gay patients. Context for care.

    PubMed Central

    Gibson, G.; Saunders, D. E.

    1994-01-01

    Gays and lesbians are a part of our society and our practices: real people with real lives, not stereotypes. Understanding their inner world and their social milieu is the first step to providing care that is holistic and appropriate. The "coming out" process and other unique health issues are described. Guidance is provided on how to identify and relate to gay and lesbian patients. PMID:8199524

  3. Ian Curtis: Punk rock, epilepsy, and suicide.

    PubMed

    Tuft, Mia; Gjelsvik, Bergljot; Nakken, Karl O

    2015-11-01

    Ian Curtis was the front man of the post-punk band Joy Division. He suffered from epilepsy and actively incorporated his experiences of the disease in his lyrics. Curtis had frequent epileptic seizures, both on and off stage. After dying from suicide in 1980, he became a legend in the post-punk milieu. The impact which the epilepsy, the epilepsy treatment, and comorbid depression had on his artistic life and premature death is not well known. PMID:26496010

  4. Promoting a healthy skepticism with regard to information processing

    SciTech Connect

    Stevens, D.F.

    1991-01-01

    Computer security professionals and members of collaborative research environments have conflicting objectives with respect to computer and network access, and different understandings of what constitutes a reasonable'' organization. These differences create tension between the two communities and make the achievement of an acceptable level of security a matter of some difficulty in such environments. We consider some of the differences and present the elements of a program aimed at promoting sensible computer and network security in the research milieu.

  5. Sir Paul Nurse.

    PubMed

    Birmingham, K

    2001-11-01

    Prizes in science don't come any bigger than the Nobels, and more often than not this award catapults its recipients from the general research milieu into the realms of scientific stardom. In this, its centenary year, the Nobel committee for Physiology or Medicine decided to honor investigators who have identified vital components of the cell cycle. Nature Medicine talked to one of the winners, Sir Paul Nurse.

  6. Curt Richter: psychobiology and the concept of instinct.

    PubMed

    Schulkin, Jay

    2007-11-01

    Curt Richter is at the origins of psychobiology in the United States. For Richter the concept of instinct was central to his research. While he had diverse interests that traversed a great range of psychobiology, the concept of instinct was fundamental to his research on specific hungers and the regulation of the internal milieu. Debates about the concept of instinct would last the bulk of Richter's experimental career, culminating in an international conference a decade after the Second World War.

  7. [Measurements of electric membrane potentials in lymphocytes].

    PubMed

    Kowal, E; Malofiejew, M; Kostrzewska, A

    1975-01-01

    The interior of vital lymphocytes, as opposed to their outer environment, has a negative electric potential (rest potential), the magnitude of which depends on the potassium ion concentration of the extracellular medium. The bioelectric phenomena at the lymphocyte are determined not only by the functional state of the cell membrane, but also by the milieu of the blood cells which includes also the adsorbed proteins and lipids. PMID:1199616

  8. Systematic identification of cis-silenced genes by trans complementation

    PubMed Central

    Lee, Jae Hyun; Bugarija, Branimir; Millan, Enrique J.; Walton, Noah M.; Gaetz, Jedidiah; Fernandes, Croydon J.; Yu, Wei-Hua; Mekel-Bobrov, Nitzan; Vallender, Tammy W.; Snyder, Gregory E.; Xiang, Andy Peng; Lahn, Bruce T.

    2009-01-01

    A gene’s transcriptional output is the combined product of two inputs: diffusible factors in the cellular milieu acting in trans, and chromatin state acting in cis. Here, we describe a strategy for dissecting the relative contribution of cis versus trans mechanisms to gene regulation. Referred to as trans complementation, it entails fusing two disparate cell types and searching for genes differentially expressed between the two genomes of fused cells. Any differential expression can be causally attributed to cis mechanisms because the two genomes of fused cells share a single homogenized milieu in trans. This assay uncovered a state of transcriptional competency that we termed ‘occluded’ whereby affected genes are silenced by cis-acting mechanisms in a manner that blocks them from responding to the trans-acting milieu of the cell. Importantly, occluded genes in a given cell type tend to include master triggers of alternative cell fates. Furthermore, the occluded state is maintained during cell division and is extraordinarily stable under a wide range of physiological conditions. These results support the model that the occlusion of lineage-inappropriate genes is a key mechanism of cell fate restriction. The identification of occluded genes by our assay provides a hitherto unavailable functional readout of chromatin state that is distinct from and complementary to gene expression status. PMID:19050040

  9. Calcific uremic arteriolopathy

    PubMed Central

    Sowers, Kurt M

    2010-01-01

    Calcific uremic arteriolopathy (CUA)/calciphylaxis is an important cause of morbidity and mortality in patients with chronic kidney disease requiring renal replacement. Once thought to be rare, it is being increasingly recognized and reported on a global scale. The uremic milieu predisposes to multiple metabolic toxicities including increased levels of reactive oxygen species and inflammation. Increased oxidative stress and inflammation promote this arteriolopathy by adversely affecting endothelial function resulting in a prothrombotic milieu and significant remodeling effects on vascular smooth muscle cells. These arteriolar pathological effects include intimal hyperplasia, inflammation, endovascular fibrosis and vascular smooth muscle cell apoptosis and differentiation into bone forming osteoblast-like cells resulting in medial calcification. Systemic factors promoting this vascular condition include elevated calcium, parathyroid hormone and hyperphosphatemia with consequent increases in the calcium × phosphate product. The uremic milieu contributes to a marked increased in upstream reactive oxygen species—oxidative stress and subsequent downstream increased inflammation, in part, via activation of the nuclear transcription factor NFκB and associated downstream cytokine pathways. Consitutive anti-calcification proteins such as Fetuin-A and matrix GLA proteins and their signaling pathways may be decreased, which further contributes to medial vascular calcification. The resulting clinical entity is painful, debilitating and contributes to the excess morbidity and mortality associated with chronic kidney disease and end stage renal disease. These same histopathologic conditions also occur in patients without uremia and therefore, the term calcific obliterative arteriolopathy could be utilized in these conditions. PMID:20716935

  10. Design of Growth Factor Sequestering Biomaterials

    PubMed Central

    Belair, David G.; Le, Ngoc Nhi; Murphy, William L.

    2014-01-01

    Growth factors (GFs) are major regulatory proteins that can govern cell fate, migration, and organization. Numerous aspects of the cell milieu can modulate cell responses to GFs, and GF regulation is often achieved by the native extracellular matrix (ECM). For example, the ECM can sequester GFs and thereby control GF bioavailability. In addition, GFs can exert distinct effects depending on whether they are sequestered in solution, at two-dimensional interfaces, or within three-dimensional matrices. Understanding how the context of GF sequestering impacts cell function in the native ECM can instruct the design of soluble or insoluble GF sequestering moieties, which can then be used in a variety of bioengineering applications. This Feature Article provides an overview of the natural mechanisms of GF sequestering in the cell milieu, and reviews the recent bioengineering approaches that have sequestered GFs to modulate cell function. Results to date demonstrate that the cell response to GF sequestering depends on the affinity of the sequestering interaction, the spatial proximity of sequestering in relation to cells, the source of the GF (supplemented or endogenous), and the phase of the sequestering moiety (soluble or insoluble). We highlight the importance of context for the future design of biomaterials that can leverage endogenous molecules in the cell milieu and mitigate the need for supplemented factors. PMID:25182455

  11. Person--job match among frontline staff working in residential treatment centers: the impact of personality and child psychopathology on burnout experiences.

    PubMed

    Leon, Scott C; Visscher, Linn; Sugimura, Niwako; Lakin, Brittany L

    2008-04-01

    Prior research has shown that the personality variables extraversion and neuroticism predict burnout among frontline staff working in residential treatment centers. This study tested the hypothesis that the effect of personality on burnout would be moderated by the psychiatric characteristics of the youth served on the milieu. Two hundred and three frontline staff working in 21 residential treatment centers in Illinois serving troubled youth completed surveys regarding opinions about their jobs, the Big Five Inventory (BFI), a youth presenting problems scale for the entire milieu, and the Maslach Burnout Inventory (MBI). Results indicated that the effect of neuroticism on burnout is moderated by psychosis and posttraumatic stress disorder (PTSD); high and moderate milieu ratings of psychosis and PTSD showed a positive relationship between neurosis and burnout, while low ratings of these conditions showed no relationship. These findings suggest that the optimal work setting is a function of the interaction between specific personality characteristics and specific work environments, with implications for personnel selection and future research on person-environment fit.

  12. The complex role of adiponectin in chronic kidney disease.

    PubMed

    Jia, Ting; Carrero, Juan Jesús; Lindholm, Bengt; Stenvinkel, Peter

    2012-10-01

    Although adiponectin, an adipocytokine released from adipose tissue, is thought to have anti-atherogenic, anti-inflammatory, and insulin-sensitizing effects, it appears that high, rather than low, circulating levels of adiponectin predict increased mortality in chronic kidney disease (CKD) patients in whom the circulating levels may rise to about three times higher than the levels in healthy subjects. As it could be hypothesized that in the uremic milieu high adiponectin levels reflect protein-energy wasting, lower residual renal function and/or volume overload, this may explain, at least in part, the observed paradoxical link between hyperadiponectinemia and poor outcome in CKD. To determine the biological consequences of high circulating adiponectin levels on carbohydrate and insulin metabolism as well as relations with cardiovascular function and mortality in the uremic milieu, further studies need to take into account both high-, and low-molecular weight adiponectin moieties as well as the role of adiponectin receptors. This brief review summarizes some of the recent advances in our understanding of the complex and context-sensitive role of this elusive and intriguing adipokine in the uremic milieu.

  13. Activite locomotrice de souris isolees, de deux lignees consanguines, dans un environnement semi-naturel ou en cages d'elevage.

    PubMed

    Le Pape, G; Lassalle, J M

    1979-10-01

    Des enregistrements continus d'activité locomotrice ont été effectués sur des souris mâles isolées des lignées Balb/c et C57bl/6, vivant en cages d'élevage ou en milieu semi- naturel. Les résultats montrent que les différences entre ces deux situations ne sont pas perçues de la même façon par les animaux des deux lign'ees: alors qu'en cages d'élevage les souris des deux lignées experiment la même quantité totale d'activaté, en milieu semi-naturel les souris Balb/c sont plus actives que les C57bl/6. En outre, l≐s différences observées entre les lignées pour la repartition de l'activité au cours du nycthèmere s'inversent lorsque l'on passe d'une situation à l'autre. L'étude de la variabilité fait aparaître une dispersion plus grande des performances dans la lignée C57bl/6 en cages d'élevage, alors qu'en milieu semi-naturel la dispersion est plus chez Bal/c.

  14. HIV-induced kidney cell injury: role of ROS-induced downregulated vitamin D receptor

    PubMed Central

    Salhan, Divya; Husain, Mohammad; Subrati, Ashaan; Goyal, Rohan; Singh, Tejinder; Rai, Partab; Malhotra, Ashwani

    2012-01-01

    Reactive oxygen species (ROS) have been demonstrated to contribute to HIV-induced tubular cell injury. We hypothesized that HIV-induced ROS generation may be causing tubular cell injury through downregulation of vitamin D receptor (VDR) and associated downstream effects. In the present study, HIV not only downregulated tubular cell VDR expression but also inflicted DNA injury. On the other hand, EB-1089, a VDR agonist (VD), inhibited both downregulation of VDR and tubular cell DNA injury in the HIV milieu. H2O2 (an O− donor) directly downregulated tubular cell VDR, whereas catalase, a free radical scavenger, inhibited HIV-induced downregulation of tubular cell VDR expression. HIV also stimulated the tubular cell renin-angiotensin system (RAS) through downregulation of VDR. Because losartan (an ANG II blolcker) partially inhibited HIV-induced tubular cell ROS generation while ANG II directly stimulated tubular cell ROS generation, it appears that HIV-induced ROS production was partly contributed by the RAS activation. VD not only inhibited HIV-induced RAS activation but also attenuated tubular cell ROS generation. Tubular cells displayed double jeopardy in the HIV milieu induction of double-strand breaks and attenuated DNA repair; additionally, in the HIV milieu, tubular cells exhibited enhanced expression of phospho-p53 and associated downstream signaling. A VDR agonist and an ANG II blocker not only preserved expression of tubular cell DNA repair proteins but also inhibited induction of double-strand breaks. In in vivo studies, renal cortical sections of Tg26 mice displayed attenuated expression of VDR both in podocytes and tubular cells. In addition, renal cortical sections of Tg26 mice displayed enhanced oxidative stress-induced kidney cell DNA damage. These findings indicated that HIV-induced tubular cell downregulation of VDR contributed to the RAS activation and associated tubular cell DNA damage. However, both VD and RAS blockade provided protection

  15. Evidence in support of using a neurochemistry approach to identify therapy for both epilepsy and associated depression.

    PubMed

    Singh, Tanveer; Goel, Rajesh Kumar

    2016-08-01

    The present study aimed to develop a neurochemistry-based single or adjuvant therapy approach for comprehensive management of epilepsy and associated depression employing pentylenetetrazole-kindled animals. Kindling was induced in two-month-old male Swiss albino mice by administering a subconvulsant pentylenetetrazole dose (35mg/kg, i.p.) at an interval of 48±2h. These kindled animals were treated with saline and sodium valproate (300mg/kg/day, i.p.) for 15days. Except for the naïve group, all other groups were challenged with pentylenetetrazole (35mg/kg, i.p.) on days 5, 10, and 15 to evaluate the seizure severity. Depression was evaluated in all experimental groups after normalization of locomotor activity, using tail suspension and forced swim test on days 1, 5, 10, and 15. Four hours after behavioral evaluations on day 15, all animals were euthanized to collect their serum and discrete brain parts. Corticosterone levels were estimated in all the experimental groups as a marker of a dysregulated hypothalamus pituitary adrenal axis. Neurochemical alterations (norepinephrine, dopamine, tryptophan, kynurenine, serotonin, glutamate, GABA, and total nitrate levels) were also estimated in the cortical and hippocampal areas of the mouse brain. Results revealed that saline-treated kindled animals were associated with significant depression and altered neurochemical milieu in comparison with naïve animals. Chronic valproate treatment in kindled animals significantly reduced seizure severity score bud did not ameliorate associated depression or completely restore altered biochemical and neurochemical milieu. Based on the observation of neurochemical changes in all the groups, we propose that restoration of altered neurochemical milieu, elevated indoleamine 2,3-dioxygenase enzyme activity, and corticosterone levels using pharmacological tools with/out valproic acid may be explored for management of both epilepsy and comorbid depression. PMID:27423076

  16. Hybridization behavior of mixed DNA/alkylthiol monolayers on gold: characterization by surface plasmon resonance and 32P radiometric assay.

    PubMed

    Gong, Ping; Lee, Chi-Ying; Gamble, Lara J; Castner, David G; Grainger, David W

    2006-05-15

    Nucleic acid assay from a complex biological milieu is attractive but currently difficult and far from routine. In this study, DNA hybridization from serum dilutions into mixed DNA/mercaptoundecanol (MCU) adlayers on gold was monitored by surface plasmon resonance (SPR). Immobilized DNA probe and hybridized target densities on these surfaces were quantified using 32P-radiometric assays as a function of MCU diluent exposure. SPR surface capture results correlated with radiometric analysis for hybridization performance, demonstrating a maximum DNA hybridization on DNA/MCU mixed adlayers. The maximum target surface capture produced by MCU addition to the DNA probe layer correlates with structural and conformational data on identical mixed DNA/MCU adlayers on gold derived from XPS, NEXAFS, and fluorescence intensity measurements reported in a related study (Lee, C.-Y.; Gong, P.; Harbers, G. M.; Grainger, D. W.; Castner, D. G.; Gamble, L. J. Anal. Chem. 2006, 78, 3316-3325.). MCU addition into the DNA adlayer on gold also improved surface resistance to both nonspecific DNA and serum protein adsorption. Target DNA hybridization from serum dilutions was monitored with SPR on the optimally mixed DNA/MCU adlayers. Both hybridization kinetics and efficiency were strongly affected by nonspecific protein adsorption from a complex milieu even at a minimal serum concentration (e.g., 1%). No target hybridization was detected in SPR assays from serum concentrations above 30%, indicating nonspecific protein adsorption interference of DNA capture and hybridization from complex milieu. Removal of nonsignal proteins from nucleic acid targets prior to assay represents a significant issue for direct sample-to-assay nucleic acid diagnostics from food, blood, tissue, PCR mixtures, and many other biologically complex sample formats. PMID:16689533

  17. Quantifying intra- and extracellular aggregation of iron oxide nanoparticles and its influence on specific absorption rate.

    PubMed

    Jeon, Seongho; Hurley, Katie R; Bischof, John C; Haynes, Christy L; Hogan, Christopher J

    2016-09-21

    A promising route to cancer treatment is hyperthermia, facilitated by superparamagnetic iron oxide nanoparticles (SPIONs). After exposure to an alternating external magnetic field, SPIONs generate heat, quantified by their specific absorption rate (SAR, in W g(-1) Fe). However, without surface functionalization, commercially available, high SAR SPIONs (EMG 308, Ferrotec, USA) aggregate in aqueous suspensions; this has been shown to reduce SAR. Further reduction in SAR has been observed for SPIONs in suspensions containing cells, but the origin of this further reduction has not been made clear. Here, we use image analysis methods to quantify the structures of SPION aggregates in the extra- and intracellular milieu of LNCaP cell suspensions. We couple image characterization with nanoparticle tracking analysis and SAR measurements of SPION aggregates in cell-free suspensions, to better quantify the influence of cellular uptake on SPION aggregates and ultimately its influence on SAR. We find that in both the intra- and extracellular milieu, SPION aggregates are well-described by a quasifractal model, with most aggregates having fractal dimensions in the 1.6-2.2 range. Intracellular aggregates are found to be significantly larger than extracellular aggregates and are commonly composed of more than 10(3) primary SPION particles (hence they are "superaggregates"). By using high salt concentrations to generate such superaggregates and measuring the SAR of suspensions, we confirm that it is the formation of superaggregates in the intracellular milieu that negatively impacts SAR, reducing it from above 200 W g(-1) Fe for aggregates composed of fewer than 50 primary particles to below 50 W g(-1) for superaggregates. While the underlying physical mechanism by which aggregation leads to reduction in SAR remains to be determined, the methods developed in this study provide insight into how cellular uptake influences the extent of SPION aggregation, and enable estimation of the

  18. Holism and life manifestations: molecular and space-time biology.

    PubMed

    Krecek, J

    2010-01-01

    Appeals of philosophers to look for new concepts in sciences are being met with a weak response. Limited attention is paid to the relation between synthetic and analytic approach in solving problems of biology. An attempt is presented to open a discussion on a possible role of holism. The term "life manifestations" is used in accordance with phenomenology. Multicellular creatures maintain milieu intérieur to keep an aqueous milieu intracellulair in order to transform the energy of nutrients into the form utilizable for driving cellular life manifestations. Milieu intérieur enables to integrate this kind of manifestations into life manifestations of the whole multicellular creatures. The integration depends on a uniqueness and uniformity of the genome of cells, on their mutual recognition and adherence. The processes of ontogenetic development represent the natural mode of integration of cellular life manifestations. Functional systems of multicellular creatures are being established by organization of integrable cells using a wide range of developmental processes. Starting from the zygote division the new being displays all properties of a whole creature, although its life manifestations vary. Therefore, the whole organism is not only more than its parts, as supposed by holism, but also more than developmental stages of its life manifestations. Implicitly, the units of whole multicellular creature are rather molecular and developmental events than the cells per se. Holism, taking in mind the existence of molecular and space-time biology, could become a guide in looking for a new mode of the combination of analytical and synthetic reasoning in biology.

  19. NK-cell dysfunction in human renal carcinoma reveals diacylglycerol kinase as key regulator and target for therapeutic intervention.

    PubMed

    Prinz, Petra U; Mendler, Anna N; Brech, Dorothee; Masouris, Ilias; Oberneder, Ralph; Noessner, Elfriede

    2014-10-15

    The relevance of NK cells in tumor control is well established in mouse models and human hematologic malignancies; however, their contribution to the control of human solid tumors remains disputed due to problems with in situ detection and reports of functional inactivity in the tumor milieu. In this study, we established a reliable in situ detection method for NK cells. Moreover, we performed analysis to elucidate mechanisms that impair NK-cell function in the tumor milieu and thereby identify therapeutic targets that allow recovery of NK-cell functionality. It was observed that NK cells from clear cell renal cell carcinoma (ccRCC), compared to NK cells from nontumor kidney and peripheral blood lymphocytes (PBLs), displayed conjoint phenotypic alterations and dysfunction induced by the tumor milieu, which were associated mechanistically with high levels of signaling attenuator diacylglycerol kinase (DGK)-α and blunted mitogen-activated protein kinase pathway activation (ERK1/2, Jun kinase). Reinstating NK-cell functionality was possible by DGK inhibition or brief IL-2 culture, interventions that de-repressed the ERK pathway. The extent of alteration and magnitude of recovery could be linked to NK-cell frequency within ccRCC-infiltrating lymphocytes, possibly explaining the observed survival benefit of patients with NK(high) tumors. In conclusion, DGK-mediated dampening of the ERK pathway ensuing in NK-cell dysfunction was identified as an important escape mechanism in ccRCC. DGK and the ERK pathway thus emerge as promising therapeutic targets to restore suppressed NK-cell activity for the improvement of antitumor immunity.

  20. Sadistic homosexual pedophilia: treatment with cyproterone acetate: a single case study.

    PubMed

    Bradford, J M; Pawlak, A

    1987-02-01

    This single case study demonstrates the effects of antiandrogen treatment on a subject with a very serious sexual deviation and a poor prognosis. It assesses the effects of cyproterone acetate (CPA) on an individual with a serious chronic organic brain syndrome combined with sadistic homosexual pedophilia. Furthermore, this individual had failed to respond to a behavioural treatment program and long-term milieu therapy. Finally, this case study is the first report of CPA differentially affecting penile responses to deviant and non-deviant stimuli.

  1. Neuroscience, Ethics, and National Security: The State of the Art

    PubMed Central

    Tennison, Michael N.; Moreno, Jonathan D.

    2012-01-01

    National security organizations in the United States, including the armed services and the intelligence community, have developed a close relationship with the scientific establishment. The latest technology often fuels warfighting and counter-intelligence capacities, providing the tactical advantages thought necessary to maintain geopolitical dominance and national security. Neuroscience has emerged as a prominent focus within this milieu, annually receiving hundreds of millions of Department of Defense dollars. Its role in national security operations raises ethical issues that need to be addressed to ensure the pragmatic synthesis of ethical accountability and national security. PMID:22448146

  2. Three dimensional time-gated tracking of non-blinking quantum dots in live cells

    DOE PAGESBeta

    DeVore, Matthew S.; Werner, James H.; Goodwin, Peter M.; Keller, Aaron M.; Hollingsworth, Jennifer A.; Wilson, Bridget S.; Cleyrat, Cedric; Lidke, Diane S.; Ghosh, Yagnaseni; Stewart, Michael H.; et al

    2015-03-12

    Single particle tracking has provided a wealth of information about biophysical processes such as motor protein transport and diffusion in cell membranes. However, motion out of the plane of the microscope or blinking of the fluorescent probe used as a label generally limits observation times to several seconds. Here, we overcome these limitations by using novel non-blinking quantum dots as probes and employing a custom 3D tracking microscope to actively follow motion in three dimensions (3D) in live cells. As a result, signal-to-noise is improved in the cellular milieu through the use of pulsed excitation and time-gated detection.

  3. Marcello Malpighi and the difficult birth of modern life sciences.

    PubMed

    Piccolino, M

    1999-01-01

    All his life, Marcello Malpighi (1628-1694), the founder of modern microscopic anatomy, was unwillingly involved in difficult debates within a reactionary medical milieu that questioned the significance of modern science and its utility to medicine. Malpighi's responses to his detractors, included in posthumous works first published in 1697 by the Royal Society, offer an important insight into a critical phase of scientific progress in the 17th century and help to reveal the prevailing conception of science. In some ways, Malpighi's views predate important ideas in modern biology.

  4. The Post-Darwinian Controversies

    NASA Astrophysics Data System (ADS)

    Moore, James R.

    1981-11-01

    Preface; Introduction: the terrain of revision; Part I. Historians and Historiography: 1. Draper, White, and the military metaphor; 2. Politics, polemics, and the military milieu; 3. Warfare's toll in historical interpretation; 4. Towards a non-violent history; Part II. Darwinism and Evolutionary Thought: 5. Darwinism in transition; 6. The challenge of Lamarckian evolution; 7. The vogue of Herbert Spencer; 8. Darwinism and Neo-Darwinism; Part III. Theology and Evolution: 9. Christian anti-Darwinism: the realm of certainty and fixity; 10. Christian Darwinism: the role of providence and progress; 11. Christian Darwinism: the relevance of orthodox theology; 12. Darwinism and Darwinisticism in theology; Conclusion; Notes to the text; Bibliography; Index.

  5. Polymicrobial Interactions: Impact on Pathogenesis and Human Disease

    PubMed Central

    Peters, Brian M.; Jabra-Rizk, Mary Ann; O'May, Graeme A.; Costerton, J. William

    2012-01-01

    Summary: Microorganisms coexist in a complex milieu of bacteria, fungi, archaea, and viruses on or within the human body, often as multifaceted polymicrobial biofilm communities at mucosal sites and on abiotic surfaces. Only recently have we begun to appreciate the complicated biofilm phenotype during infection; moreover, even less is known about the interactions that occur between microorganisms during polymicrobial growth and their implications in human disease. Therefore, this review focuses on polymicrobial biofilm-mediated infections and examines the contribution of bacterial-bacterial, bacterial-fungal, and bacterial-viral interactions during human infection and potential strategies for protection against such diseases. PMID:22232376

  6. Cultural Safety: An Evolutionary Concept Analysis.

    PubMed

    Parisa, Bozorgzad; Reza, Negarandeh; Afsaneh, Raiesifar; Sarieh, Poortaghi

    2016-01-01

    Healing occurs in a safe milieu, and patients feel safe when service providers view them as whole persons, recognizing the multiple underlying factors that cause illness. Cultural safety can lead to service delivery in this way, but most nurses have no clear understanding of this concept. This study aimed to clarify cultural safety on the basis of Rodgers' evolutionary concept analysis. Cultural sensitivity and cultural awareness are the antecedents of cultural safety. These concepts include a nurse's flexibility toward his or her patients with different perspectives, creating an atmosphere free from intimidation and judgment of the patients, with an overall promotion of health in multicultural communities. PMID:26633724

  7. Invisibility and selective avoidance: gender and ethnicity in psychiatry and psychiatric nursing staff interaction.

    PubMed

    Kavanagh, K H

    1991-06-01

    This research-based article analyzes institutionalized inequity and discrimination in the forms of sexism and racism within a large, busy, contemporary medical center's Department of Psychiatry. Within that context, issues of control and mechanisms of avoidance served to perpetuate contradictions inherent in what professes to be a psychologically therapeutic and empowering milieu. Despite cognizance of the roles that culture and gender play in care and treatment of patients, psychiatric and mental health professionals at "Central" tended to avoid critical examination of their own and co-workers' ethnicity and gender as those characteristics influenced life experiences, occupational roles and statuses, and hierarchical relationships.

  8. Report on the 56th ASH Annual Meeting, San Francisco, 4–9 December 2014

    PubMed Central

    Agazzi, Alberto

    2015-01-01

    The 56th annual ASH (American Society of Haematology) meeting was held in San Francisco (CA). More than 3,000 abstracts were selected for presentation due to the huge amount of information from basic science to clinical experience. The future direction in haematoncology is targeted therapies for most diseases; for instance, anti-PD-1 and CAR-T cells in lymphoproliferative disorders and novel immunomodulatory agents active in the contest of bone marrow milieu in multiple myeloma. On the other hand, in aggressive haematological diseases (AML, ALL), clinical studies demonstrated the feasibility of a more intensive chemotherapy approach in older patients. PMID:25729427

  9. Topography, Cell Response, and Nerve Regeneration

    PubMed Central

    Hoffman-Kim, Diane; Mitchel, Jennifer A.; Bellamkonda, Ravi V.

    2010-01-01

    In the body, cells encounter a complex milieu of signals, including topographical cues. Imposed topography can affect cells on surfaces by promoting adhesion, spreading, alignment, morphological changes, and changes in gene expression. Neural response to topography is complex, and depends on the dimensions and shapes of physical features. Looking toward repair of nerve injuries, strategies are being explored to engineer guidance conduits with precise surface topographies. How neurons and other cell types sense and interpret topography remains to be fully elucidated. Studies reviewed here include those of topography on cellular organization and function as well as potential cellular mechanisms of response. PMID:20438370

  10. The influences of the transfer method and particle surface chemistry on the dispersion of nanoparticles in nanocomposites

    NASA Astrophysics Data System (ADS)

    Pravaz, Olivier; Droz, Benoît; Schurtenberger, Peter; Dietsch, Hervé

    2012-10-01

    The synthesis via in situ polymerization and characterization of nanocomposites (NCs) made from silica (SiO2) nanoparticles in a methyl methacrylate (MMA) monomer matrix is reported. We first investigate the transfer of well-defined spherical silica nanoparticles (NPs) (average radius R = 24.2 +/- 3.2 nm) into the monomer solvent. We study the influence of two transfer methods and different surface chemistries on the resulting colloidal stability. The first transfer method consists of drying the silica particles into powder before dispersing them via ultrasonication in the MMA matrix. The second is based on repetitive centrifugations to exchange NPs from their synthetic milieu to pure MMA, avoiding the dried powder state. These transfer methods are compared for two kinds of NP surface chemistry, natural silanol (Si-OH) groups of the silica NPs and an additional silane coupling agent, namely 3-(trimethoxysilyl)propyl methacrylate (TPM), which mimics the monomeric group of the MMA dispersing milieu. We then characterize the morphology of the resulting nanocomposites prepared via in situ polymerization at a fixed amount of dispersed NPs (2.2 wt%; 1 vol%) using a combination of transmission electron microscopy (TEM) from ultramicrotomed nanocomposite films, thermogravimetry (TGA) and small angle X-ray scattering (SAXS).The synthesis via in situ polymerization and characterization of nanocomposites (NCs) made from silica (SiO2) nanoparticles in a methyl methacrylate (MMA) monomer matrix is reported. We first investigate the transfer of well-defined spherical silica nanoparticles (NPs) (average radius R = 24.2 +/- 3.2 nm) into the monomer solvent. We study the influence of two transfer methods and different surface chemistries on the resulting colloidal stability. The first transfer method consists of drying the silica particles into powder before dispersing them via ultrasonication in the MMA matrix. The second is based on repetitive centrifugations to exchange NPs from

  11. Fibromyalgia, myofascial pain, tender points and trigger points: splitting or lumping?

    PubMed Central

    2011-01-01

    Myofascial trigger points (MTPs) have long been a contentious issue in relation to fibromyalgia, and poorly defined pain complaints in general. Can MTPs be reproducibly identified? Do MTPs have valid objective findings, such as spontaneous electromyographic activity, muscle microdialysis evidence for an inflammatory milieu or visualization with newer ultrasound techniques? Is fibromyalgia a syndrome of multiple MTPs, or is focal muscle tenderness a manifestation of central sensitization? These issues are discussed with relevance to a recent paper reporting that manual palpation of active MTPs elicits the spontaneous pain experienced by fibromyalgia patients. PMID:21722339

  12. Fibromyalgia, myofascial pain, tender points and trigger points: splitting or lumping?

    PubMed

    Bennett, Robert M; Goldenberg, Don L

    2011-06-30

    Myofascial trigger points (MTPs) have long been a contentious issue in relation to fibromyalgia, and poorly defined pain complaints in general. Can MTPs be reproducibly identified? Do MTPs have valid objective findings, such as spontaneous electromyographic activity, muscle microdialysis evidence for an inflammatory milieu or visualization with newer ultrasound techniques? Is fibromyalgia a syndrome of multiple MTPs, or is focal muscle tenderness a manifestation of central sensitization? These issues are discussed with relevance to a recent paper reporting that manual palpation of active MTPs elicits the spontaneous pain experienced by fibromyalgia patients.

  13. [Biological potentiality of melatonin].

    PubMed

    Muñoz Barragán, Luciano

    2002-01-01

    The pineal gland is an epithalamic structure whose mission is to integrate incoming environmental information with other types of information deriving from the inner milieu itself of the organism, releasing melatonin, a substance able to elicit responses in the central nervous and endocrine systems. Secreted rhythmically during the scotophase, melatonin is involved in reproductive mechanisms, in cyclically developing nosological. Processes, and in the genesis or maintenance of cerebral biorhythms. Owing to its ability to uptake free radicals produced by cell metabolism, it is a potent antioxidant agent that is able to delay cellular ageing and inhibit cellular proliferation in both experimental and spontaneous tumours. PMID:12812036

  14. Primary and Secondary Prevention of Cardiovascular Diseases: A Practical Evidence-Based Approach

    PubMed Central

    O'Keefe, James H.; Carter, Maia D.; Lavie, Carl J.

    2009-01-01

    Despite the fact that we possess highly effective tools for the primary and secondary prevention of myocardial infarction and other complications of atherosclerosis, coronary heart disease remains the most common cause of death in our society. Arterial inflammation and endothelial dysfunction play central roles in the pathogenesis of atherosclerosis and adverse cardiovascular (CV) events. Therapeutic lifestyle changes in conjunction with an aggressive multidrug regimen targeted toward the normalization of the major CV risk factors will neutralize the atherogenic milieu, reduce vascular inflammation, and markedly decrease the risk of adverse CV events and need for revascularization procedures. Specific CV risk factors and optimal therapies for primary and secondary prevention are discussed. PMID:19648392

  15. Medical education: meeting the challenge of implementing primary health care in sub-Saharan Africa.

    PubMed

    Ahmed, Mushtaq; Vellani, Camer W; Awiti, Alex O

    2011-06-01

    Medical education in sub-Saharan Africa must be defined by its health needs and the health care services required. The sociodemographic milieu that determines the disease pattern makes a compelling case for primary health care in the context of community participation and multisector community development as the driver of a plan for medical education, in tandem with clinicians' role in continuity of care. Such ideas have been derived from the experience of planning for undergraduate medical education at the Aga Khan University Medical College, Nairobi, whose curriculum incorporates broad-based general education and liberal arts principles.

  16. Kurt Gödels Brünner Verwandte

    NASA Astrophysics Data System (ADS)

    Müller, Dora

    2007-11-01

    The author of this memoir Dora Müller (born 1920) belongs - as well as Kurt Gödel-to the German minority playing an important role in the past life of Brno. The marriage of his son included her among the Gödels collaterals. She was chemist, but also pianist, historician, participant of antinacist movement and iniciator of Czech-German understanding after war. Following her personal experiences, remembrances of Gödels relatives and documental materials, she evokes the atmosphere of broader family milieu of Kurt Gödel.

  17. The behavioral treatment of self-starvation and severe self-injury in a patient with borderline personality disorder.

    PubMed

    Bloxham, G; Long, C G; Alderman, N; Hollin, C R

    1993-09-01

    The successful treatment by behavioral methods of self-starvation and self-injury in a 35-year-old psychiatric in-patient, with a diagnosis of borderline personality disorder, is described. An individualized program using positive and negative reinforcers to increase food and fluid intake was used, while a token economy therapeutic milieu with time out was used to decrease acts of self-injury and aggression. Progress in treatment generalized to a non-secure treatment environment, and was maintained at an 8-month follow-up. The study illustrates the differential response of active and passive self injurious behaviors to group-based and individual treatments, respectively. PMID:8188851

  18. Importance of environmental and occupational factors in cancer.

    PubMed

    Higginson, J

    1980-01-01

    Geographic and temporal variations in cancer incidence, changes in migrants, differences between males and females, as well as case history studies are discussed. Cancers of the workplace can be divided into those related to "point-source" industrial pollution and those where the social milieu or "life-style" of the occupation play a role (e.g., job-associated cancers). In the future, considerably more effort is necessary in studying the life-style factors in specific occupational settings. It is important not to forget that occupational cancer is essentially an excess risk over the background risks. PMID:7463524

  19. The outs and ins of bacterial type IV secretion substrates

    PubMed Central

    Ding, Zhiyong; Atmakuri, Krishnamohan; Christie, Peter J.

    2016-01-01

    Bacteria use type IV secretion systems (T4SS) to translocate macromolecular substrates destined for bacterial, plant or human target cells. The T4SS are medically important, contributing to virulence-gene spread, genome plasticity and the alteration of host cellular processes during infection. The T4SS are ancestrally related to bacterial conjugation machines, but present-day functions include (i) conjugal transfer of DNA by cell-to-cell contact, (ii) translocation of effector molecules to eukaryotic target cells, and (iii) DNA uptake from or release to the extracellular milieu. Rapid progress has been made toward identification of type IV secretion substrates and the requirements for substrate recognition. PMID:14607070

  20. Electron tunnelling through single azurin molecules can be on/off switched by voltage pulses

    SciTech Connect

    Baldacchini, Chiara; Kumar, Vivek; Bizzarri, Anna Rita; Cannistraro, Salvatore

    2015-05-04

    Redox metalloproteins are emerging as promising candidates for future bio-optoelectronic and nano-biomemory devices, and the control of their electron transfer properties through external signals is still a crucial task. Here, we show that a reversible on/off switching of the electron current tunnelling through a single protein can be achieved in azurin protein molecules adsorbed on gold surfaces, by applying appropriate voltage pulses through a scanning tunnelling microscope tip. The observed changes in the hybrid system tunnelling properties are discussed in terms of long-sustained charging of the protein milieu.